locus-tag	class	description
HHK01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHK01_RS00010	COG0592	DNA-directed DNA polymerase activity
HHK01_RS00015	COG2501	S4 domain
HHK01_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HHK01_RS00030	COG0187	DNA topoisomerase II activity
HHK01_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHK01_RS00075	COG0516	GMP reductase activity
HHK01_RS00075	COG0517	IMP dehydrogenase activity
HHK01_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HHK01_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HHK01_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHK01_RS00115	COG1428	Deoxynucleoside kinase
HHK01_RS00120	COG1428	Deoxynucleoside kinase
HHK01_RS00130	COG1388	LysM domain
HHK01_RS00130	COG3858	chitin binding
HHK01_RS00135	COG1335	isochorismatase
HHK01_RS00140	COG0590	tRNA wobble adenosine to inosine editing
HHK01_RS00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHK01_RS00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HHK01_RS00160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HHK01_RS00200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HHK01_RS00210	COG3880	PFAM UvrB UvrC protein
HHK01_RS00215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HHK01_RS00220	COG0542	response to heat
HHK01_RS00225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHK01_RS00235	COG4956	integral membrane protein (PIN domain superfamily)
HHK01_RS00240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HHK01_RS00250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHK01_RS00255	COG1045	serine acetyltransferase
HHK01_RS00260	COG0215	cysteine-tRNA ligase activity
HHK01_RS00270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHK01_RS00275	COG3688	RNA-binding protein containing a PIN domain
HHK01_RS00285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHK01_RS00290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHK01_RS00295	COG0250	Participates in transcription elongation, termination and antitermination
HHK01_RS00300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHK01_RS00305	COG0081	regulation of translation
HHK01_RS00310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HHK01_RS00315	COG0222	ribosome binding
HHK01_RS00320	COG2813	Specifically methylates the guanine in position
HHK01_RS00330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHK01_RS00335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HHK01_RS00340	COG0049	tRNA binding
HHK01_RS00345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHK01_RS00350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHK01_RS00355	COG0714	Associated with various cellular activities
HHK01_RS00370	COG0051	transcription antitermination factor activity, RNA binding
HHK01_RS00375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HHK01_RS00380	COG0088	Forms part of the polypeptide exit tunnel
HHK01_RS00390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHK01_RS00395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHK01_RS00405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHK01_RS00415	COG0255	Belongs to the universal ribosomal protein uL29 family
HHK01_RS00420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HHK01_RS00425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HHK01_RS00435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HHK01_RS00440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHK01_RS00445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HHK01_RS00450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HHK01_RS00455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHK01_RS00460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HHK01_RS00465	COG1841	ribosomal large subunit assembly
HHK01_RS00475	COG0201	protein transport
HHK01_RS00480	COG0563	adenylate kinase activity
HHK01_RS00485	COG0024	Methionine aminopeptidase
HHK01_RS00500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHK01_RS00505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHK01_RS00510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHK01_RS00515	COG0202	RNA polymerase activity
HHK01_RS00530	COG1122	ATPase activity
HHK01_RS00535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HHK01_RS00540	COG0101	tRNA pseudouridine synthase activity
HHK01_RS00545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHK01_RS00550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HHK01_RS00560	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHK01_RS00565	COG0489	protein tyrosine kinase activity
HHK01_RS00575	COG2194	sulfuric ester hydrolase activity
HHK01_RS00580	COG0726	polysaccharide deacetylase
HHK01_RS00610	COG1982	Orn Lys Arg decarboxylase major
HHK01_RS00615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHK01_RS00620	COG3870	Protein conserved in bacteria
HHK01_RS00625	COG1728	Protein conserved in bacteria
HHK01_RS00630	COG0470	DNA polymerase III
HHK01_RS00635	COG1774	PSP1 C-terminal conserved region
HHK01_RS00640	COG4467	Involved in initiation control of chromosome replication
HHK01_RS00645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HHK01_RS00655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HHK01_RS00660	COG2002	toxin-antitoxin pair type II binding
HHK01_RS00665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHK01_RS00665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHK01_RS00670	COG0084	hydrolase, TatD family'
HHK01_RS00675	COG3583	domain protein
HHK01_RS00675	COG3584	3D domain protein
HHK01_RS00680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HHK01_RS00685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HHK01_RS00695	COG4466	Protein conserved in bacteria
HHK01_RS00705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HHK01_RS00710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHK01_RS00715	COG0251	oxidation-reduction process
HHK01_RS00725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHK01_RS00735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHK01_RS00740	COG0193	aminoacyl-tRNA hydrolase activity
HHK01_RS00750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHK01_RS00755	COG2002	toxin-antitoxin pair type II binding
HHK01_RS00760	COG2244	polysaccharide biosynthetic process
HHK01_RS00765	COG3956	TIGRFAM MazG family protein
HHK01_RS00770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHK01_RS00790	COG1098	S1 RNA binding domain
HHK01_RS00805	COG2208	phosphoserine phosphatase activity
HHK01_RS00810	COG2304	oxidoreductase activity
HHK01_RS00815	COG0515	serine threonine protein kinase
HHK01_RS00820	COG0037	tRNA processing
HHK01_RS00825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HHK01_RS00830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHK01_RS00835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HHK01_RS00840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHK01_RS00845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHK01_RS00850	COG1263	PTS System
HHK01_RS00850	COG2190	(PTS) system
HHK01_RS00850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHK01_RS00855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHK01_RS00860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHK01_RS00865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHK01_RS00870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHK01_RS00875	COG1396	sequence-specific DNA binding
HHK01_RS00880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHK01_RS00885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HHK01_RS01000	COG1595	DNA-templated transcription, initiation
HHK01_RS01015	COG4856	YbbR-like protein
HHK01_RS01020	COG4856	YbbR-like protein
HHK01_RS01035	COG1937	Protein conserved in bacteria
HHK01_RS01050	COG0534	Mate efflux family protein
HHK01_RS01055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHK01_RS01105	COG2096	Adenosyltransferase
HHK01_RS01130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHK01_RS01135	COG0588	phosphoglycerate mutase activity
HHK01_RS01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHK01_RS01165	COG0517	IMP dehydrogenase activity
HHK01_RS01180	COG1733	regulation of RNA biosynthetic process
HHK01_RS01185	COG2259	Doxx family
HHK01_RS01190	COG2514	catechol 2,3-dioxygenase activity
HHK01_RS01225	COG4214	carbohydrate transport
HHK01_RS01235	COG2972	Histidine kinase
HHK01_RS01240	COG2197	response regulator
HHK01_RS01245	COG4213	ABC transporter substrate-binding protein
HHK01_RS01255	COG3853	Toxic anion resistance protein (TelA)
HHK01_RS01260	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HHK01_RS01275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS01275	COG3711	transcriptional antiterminator
HHK01_RS01280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS01280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS01285	COG1482	cell wall glycoprotein biosynthetic process
HHK01_RS01320	COG0488	(ABC) transporter
HHK01_RS01370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HHK01_RS01375	COG0730	response to heat
HHK01_RS01390	COG0745	RESPONSE REGULATOR receiver
HHK01_RS01395	COG2205	protein histidine kinase activity
HHK01_RS01405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHK01_RS01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHK01_RS01420	COG0129	dihydroxy-acid dehydratase activity
HHK01_RS01425	COG0028	Belongs to the TPP enzyme family
HHK01_RS01430	COG0440	acetolactate synthase activity
HHK01_RS01435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHK01_RS01440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHK01_RS01445	COG0473	3-isopropylmalate dehydrogenase activity
HHK01_RS01450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHK01_RS01455	COG0066	3-isopropylmalate dehydratase activity
HHK01_RS01460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHK01_RS01475	COG2814	Major facilitator Superfamily
HHK01_RS01505	COG0583	DNA-binding transcription factor activity
HHK01_RS01510	COG1053	succinate dehydrogenase
HHK01_RS01530	COG1473	amidohydrolase
HHK01_RS01535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HHK01_RS01555	COG0800	Aldolase
HHK01_RS01560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHK01_RS01570	COG0604	alcohol dehydrogenase
HHK01_RS01575	COG0003	Pfam Anion-transporting ATPase
HHK01_RS01585	COG1966	Carbon starvation protein
HHK01_RS01590	COG1657	PFAM Prenyltransferase squalene oxidase
HHK01_RS01600	COG0217	transcriptional regulatory protein
HHK01_RS01625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHK01_RS01630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHK01_RS01635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HHK01_RS01640	COG2124	cytochrome p450
HHK01_RS01655	COG3395	kinase activity
HHK01_RS01660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HHK01_RS01675	COG0733	neurotransmitter:sodium symporter activity
HHK01_RS01680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHK01_RS01690	COG4191	Histidine kinase
HHK01_RS01705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HHK01_RS01710	COG4988	ABC transporter
HHK01_RS01715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHK01_RS01745	COG3546	catalase activity
HHK01_RS01765	COG0697	spore germination
HHK01_RS01785	COG4667	esterase of the alpha-beta hydrolase superfamily
HHK01_RS01805	COG2084	Dehydrogenase
HHK01_RS01810	COG3663	DNA glycosylase
HHK01_RS01820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HHK01_RS01830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHK01_RS01850	COG0517	IMP dehydrogenase activity
HHK01_RS01855	COG1686	Belongs to the peptidase S11 family
HHK01_RS01860	COG3173	Aminoglycoside phosphotransferase
HHK01_RS01865	COG1054	Belongs to the UPF0176 family
HHK01_RS01870	COG1228	amidohydrolase
HHK01_RS01875	COG1132	(ABC) transporter
HHK01_RS01885	COG0784	Response regulator, receiver
HHK01_RS01885	COG2205	protein histidine kinase activity
HHK01_RS01890	COG0745	RESPONSE REGULATOR receiver
HHK01_RS01920	COG3181	Tripartite tricarboxylate transporter family receptor
HHK01_RS01925	COG4565	transcriptional regulatory protein
HHK01_RS01930	COG3290	protein histidine kinase activity
HHK01_RS01940	COG0318	PFAM AMP-dependent synthetase and ligase
HHK01_RS01945	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS01950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHK01_RS01955	COG2011	ABC-type metal ion transport system permease component
HHK01_RS01960	COG1464	Belongs to the NlpA lipoprotein family
HHK01_RS01975	COG0431	NADPH-dependent FMN reductase
HHK01_RS01980	COG1733	regulation of RNA biosynthetic process
HHK01_RS01985	COG2259	Doxx family
HHK01_RS01990	COG2514	catechol 2,3-dioxygenase activity
HHK01_RS01995	COG2226	methyltransferase
HHK01_RS02005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHK01_RS02020	COG4895	conserved protein (DUF2196)
HHK01_RS02025	COG1834	amidinotransferase
HHK01_RS02030	COG0626	cystathionine gamma-synthase activity
HHK01_RS02035	COG2188	Transcriptional regulator
HHK01_RS02055	COG1280	lysine exporter protein (LysE YggA)
HHK01_RS02060	COG1113	amino acid transport
HHK01_RS02075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHK01_RS02080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHK01_RS02085	COG1505	serine-type exopeptidase activity
HHK01_RS02105	COG2323	membrane
HHK01_RS02115	COG2132	Multicopper oxidase
HHK01_RS02120	COG0551	DNA topoisomerase type I activity
HHK01_RS02120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHK01_RS02125	COG2996	Protein conserved in bacteria
HHK01_RS02130	COG2814	Major facilitator Superfamily
HHK01_RS02140	COG2814	Major facilitator Superfamily
HHK01_RS02150	COG2986	histidine ammonia-lyase
HHK01_RS02155	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HHK01_RS02160	COG1228	amidohydrolase
HHK01_RS02165	COG0010	Belongs to the arginase family
HHK01_RS02180	COG0488	(ABC) transporter
HHK01_RS02185	COG0697	spore germination
HHK01_RS02200	COG0346	lactoylglutathione lyase activity
HHK01_RS02220	COG1278	Cold shock
HHK01_RS02230	COG0697	spore germination
HHK01_RS02235	COG1063	alcohol dehydrogenase
HHK01_RS02250	COG2268	Band 7 protein
HHK01_RS02255	COG1585	Membrane protein implicated in regulation of membrane protease activity
HHK01_RS02260	COG0778	Nitroreductase
HHK01_RS02270	COG4536	flavin adenine dinucleotide binding
HHK01_RS02280	COG0154	amidase activity
HHK01_RS02300	COG4191	Histidine kinase
HHK01_RS02310	COG2357	RelA SpoT domain protein
HHK01_RS02320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHK01_RS02335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHK01_RS02340	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS02345	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS02355	COG0601	transmembrane transport
HHK01_RS02360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS02370	COG3711	transcriptional antiterminator
HHK01_RS02380	COG0246	Mannitol dehydrogenase
HHK01_RS02385	COG0723	plastoquinol--plastocyanin reductase activity
HHK01_RS02385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHK01_RS02390	COG2364	Membrane
HHK01_RS02400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHK01_RS02420	COG1595	DNA-templated transcription, initiation
HHK01_RS02430	COG4176	ABC-type proline glycine betaine transport system permease component
HHK01_RS02435	COG0517	IMP dehydrogenase activity
HHK01_RS02435	COG4175	Glycine betaine
HHK01_RS02445	COG0366	Alpha amylase catalytic
HHK01_RS02455	COG1272	protein, Hemolysin III
HHK01_RS02460	COG3695	enzyme binding
HHK01_RS02485	COG1757	Na H antiporter
HHK01_RS02500	COG0730	response to heat
HHK01_RS02505	COG4555	ABC transporter
HHK01_RS02515	COG0772	Belongs to the SEDS family
HHK01_RS02520	COG1253	flavin adenine dinucleotide binding
HHK01_RS02525	COG1253	flavin adenine dinucleotide binding
HHK01_RS02540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHK01_RS02545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHK01_RS02555	COG0513	Belongs to the DEAD box helicase family
HHK01_RS02560	COG3402	PFAM membrane-flanked domain
HHK01_RS02565	COG3428	Bacterial PH domain
HHK01_RS02570	COG0705	Rhomboid family
HHK01_RS02575	COG0736	holo-[acyl-carrier-protein] synthase activity
HHK01_RS02580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HHK01_RS02590	COG0864	Transcriptional regulator
HHK01_RS02595	COG2337	Toxic component of a toxin-antitoxin (TA) module
HHK01_RS02600	COG2172	sigma factor antagonist activity
HHK01_RS02605	COG2208	phosphoserine phosphatase activity
HHK01_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
HHK01_RS02615	COG2172	sigma factor antagonist activity
HHK01_RS02620	COG1191	sigma factor activity
HHK01_RS02625	COG2183	response to ionizing radiation
HHK01_RS02635	COG3091	SprT-like family
HHK01_RS02720	COG0802	atpase or kinase
HHK01_RS02725	COG1214	PFAM Peptidase M22, glycoprotease
HHK01_RS02730	COG0456	acetyltransferase
HHK01_RS02735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HHK01_RS02740	COG0488	(ABC) transporter
HHK01_RS02745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HHK01_RS02750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHK01_RS02755	COG0805	protein transport
HHK01_RS02765	COG1266	CAAX protease self-immunity
HHK01_RS02775	COG0459	protein refolding
HHK01_RS02785	COG0714	Associated with various cellular activities
HHK01_RS02790	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HHK01_RS02795	COG1305	Transglutaminase-like
HHK01_RS02800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHK01_RS02800	COG0519	Catalyzes the synthesis of GMP from XMP
HHK01_RS02805	COG2252	PERMEase
HHK01_RS02825	COG1595	DNA-templated transcription, initiation
HHK01_RS02835	COG2217	Heavy metal translocating P-type atpase
HHK01_RS02850	COG0288	reversible hydration of carbon dioxide
HHK01_RS02855	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HHK01_RS02865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHK01_RS02870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHK01_RS02875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHK01_RS02880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHK01_RS02890	COG0047	phosphoribosylformylglycinamidine synthase activity
HHK01_RS02895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHK01_RS02900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HHK01_RS02905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHK01_RS02910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHK01_RS02915	COG0138	bifunctional purine biosynthesis protein purh
HHK01_RS02920	COG0151	Belongs to the GarS family
HHK01_RS02935	COG1470	cell adhesion involved in biofilm formation
HHK01_RS02940	COG4496	protein, YerC YecD
HHK01_RS02960	COG0210	DNA helicase
HHK01_RS02965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHK01_RS02970	COG4851	CamS sex pheromone cAM373 precursor
HHK01_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
HHK01_RS02980	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HHK01_RS02985	COG0656	L-ascorbic acid biosynthetic process
HHK01_RS02995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHK01_RS03000	COG2340	Cysteine-rich secretory protein family
HHK01_RS03005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHK01_RS03010	COG0154	amidase activity
HHK01_RS03035	COG1597	lipid kinase activity
HHK01_RS03050	COG1090	epimerase
HHK01_RS03070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHK01_RS03110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHK01_RS03110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHK01_RS03115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHK01_RS03115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHK01_RS03120	COG0517	IMP dehydrogenase activity
HHK01_RS03125	COG1473	amidohydrolase
HHK01_RS03140	COG1733	regulation of RNA biosynthetic process
HHK01_RS03150	COG0431	NADPH-dependent FMN reductase
HHK01_RS03155	COG0431	NADPH-dependent FMN reductase
HHK01_RS03160	COG0662	Cupin 2, conserved barrel domain protein
HHK01_RS03160	COG2207	Transcriptional regulator
HHK01_RS03165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHK01_RS03170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS03175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS03185	COG1473	amidohydrolase
HHK01_RS03245	COG0601	transmembrane transport
HHK01_RS03250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS03255	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS03270	COG1132	(ABC) transporter
HHK01_RS03275	COG1132	(ABC) transporter
HHK01_RS03285	COG1131	(ABC) transporter
HHK01_RS03290	COG1725	Transcriptional regulator
HHK01_RS03295	COG0024	Methionine aminopeptidase
HHK01_RS03315	COG0546	phosphoglycolate phosphatase activity
HHK01_RS03320	COG0745	RESPONSE REGULATOR receiver
HHK01_RS03325	COG3850	Histidine kinase
HHK01_RS03325	COG5002	protein histidine kinase activity
HHK01_RS03330	COG1136	(ABC) transporter
HHK01_RS03335	COG0577	efflux transmembrane transporter activity
HHK01_RS03355	COG0242	peptide deformylase activity
HHK01_RS03370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHK01_RS03380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHK01_RS03400	COG1737	Transcriptional regulator
HHK01_RS03415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHK01_RS03425	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHK01_RS03440	COG2971	BadF BadG BcrA BcrD
HHK01_RS03470	COG1077	Cell shape determining protein MreB Mrl
HHK01_RS03475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHK01_RS03480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHK01_RS03485	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HHK01_RS03490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHK01_RS03495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHK01_RS03500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHK01_RS03515	COG0500	methyltransferase
HHK01_RS03520	COG2309	aminopeptidase activity
HHK01_RS03525	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS03530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHK01_RS03530	COG1042	CoA-binding domain protein
HHK01_RS03530	COG0045	succinate-CoA ligase (ADP-forming) activity
HHK01_RS03540	COG0471	metal ion transport
HHK01_RS03550	COG2814	Major facilitator Superfamily
HHK01_RS03565	COG1215	transferase activity, transferring glycosyl groups
HHK01_RS03585	COG1086	Polysaccharide biosynthesis protein
HHK01_RS03600	COG1216	Glycosyl transferase, family 2
HHK01_RS03605	COG1473	amidohydrolase
HHK01_RS03610	COG1473	amidohydrolase
HHK01_RS03620	COG4840	Belongs to the UPF0435 family
HHK01_RS03625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HHK01_RS03675	COG1295	ribonuclease BN
HHK01_RS03680	COG0477	Major facilitator Superfamily
HHK01_RS03710	COG1164	Oligoendopeptidase f
HHK01_RS03730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HHK01_RS03735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHK01_RS03765	COG0346	lactoylglutathione lyase activity
HHK01_RS03775	COG2226	methyltransferase
HHK01_RS03780	COG0492	ferredoxin-NADP+ reductase activity
HHK01_RS03790	COG2814	Major facilitator Superfamily
HHK01_RS03810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHK01_RS03820	COG2217	Heavy metal translocating P-type atpase
HHK01_RS03835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHK01_RS03840	COG1404	Belongs to the peptidase S8 family
HHK01_RS03850	COG4585	Histidine kinase
HHK01_RS03880	COG1090	epimerase
HHK01_RS03885	COG2137	regulation of response to DNA damage stimulus
HHK01_RS03905	COG1988	membrane-bound metal-dependent
HHK01_RS03910	COG1194	a g-specific adenine glycosylase
HHK01_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS03935	COG3557	Belongs to the UPF0374 family
HHK01_RS03940	COG1132	(ABC) transporter
HHK01_RS03955	COG4129	membrane
HHK01_RS03960	COG0069	glutamate synthase activity
HHK01_RS03960	COG0067	glutamate synthase
HHK01_RS03960	COG0070	glutamate synthase
HHK01_RS03970	COG1802	Transcriptional regulator
HHK01_RS03975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHK01_RS03980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHK01_RS03985	COG0066	3-isopropylmalate dehydratase activity
HHK01_RS03995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHK01_RS04005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHK01_RS04010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHK01_RS04015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHK01_RS04020	COG2096	Adenosyltransferase
HHK01_RS04025	COG0735	belongs to the Fur family
HHK01_RS04140	COG0681	Belongs to the peptidase S26 family
HHK01_RS04170	COG0693	protein deglycase activity
HHK01_RS04170	COG0753	catalase activity
HHK01_RS04185	COG1607	acyl-coa hydrolase
HHK01_RS04200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHK01_RS04210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HHK01_RS04215	COG0778	Nitroreductase
HHK01_RS04220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHK01_RS04225	COG2766	serine protein kinase
HHK01_RS04230	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHK01_RS04230	COG2247	cell wall binding repeat
HHK01_RS04235	COG2718	Belongs to the UPF0229 family
HHK01_RS04245	COG1349	DNA-binding transcription factor activity
HHK01_RS04250	COG1105	Belongs to the carbohydrate kinase PfkB family
HHK01_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS04255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS04255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS04260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HHK01_RS04265	COG5577	PFAM Coat F domain
HHK01_RS04270	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HHK01_RS04280	COG4187	Peptidase family M20/M25/M40
HHK01_RS04285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HHK01_RS04290	COG3396	Phenylacetate-CoA oxygenase
HHK01_RS04320	COG1024	Enoyl-CoA hydratase
HHK01_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
HHK01_RS04330	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHK01_RS04335	COG0183	Belongs to the thiolase family
HHK01_RS04340	COG1024	Enoyl-CoA hydratase
HHK01_RS04345	COG3327	negative regulation of DNA-templated transcription, initiation
HHK01_RS04350	COG2070	2-Nitropropane dioxygenase
HHK01_RS04360	COG4120	Belongs to the binding-protein-dependent transport system permease family
HHK01_RS04365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHK01_RS04405	COG0753	catalase activity
HHK01_RS04420	COG3973	AAA domain
HHK01_RS04425	COG0656	L-ascorbic acid biosynthetic process
HHK01_RS04430	COG0655	NAD(P)H dehydrogenase (quinone) activity
HHK01_RS04445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHK01_RS04445	COG3153	acetyltransferase
HHK01_RS04455	COG2719	SpoVR family
HHK01_RS04470	COG0697	spore germination
HHK01_RS04480	COG0604	alcohol dehydrogenase
HHK01_RS04490	COG0658	competence protein
HHK01_RS04490	COG2333	competence protein COMEC
HHK01_RS04500	COG1301	dicarboxylic acid transport
HHK01_RS04505	COG3859	Proton-coupled thiamine transporter YuaJ
HHK01_RS04510	COG1132	(ABC) transporter
HHK01_RS04515	COG1132	(ABC) transporter
HHK01_RS04530	COG0114	fumarate hydratase activity
HHK01_RS04550	COG3842	ATPase activity
HHK01_RS04555	COG2508	Transcriptional regulator
HHK01_RS04580	COG0189	ligase activity
HHK01_RS04585	COG0189	ligase activity
HHK01_RS04590	COG0189	ligase activity
HHK01_RS04595	COG4399	Belongs to the UPF0754 family
HHK01_RS04600	COG3679	Belongs to the UPF0342 family
HHK01_RS04610	COG0561	phosphatase activity
HHK01_RS04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHK01_RS04655	COG4152	abc transporter atp-binding protein
HHK01_RS04660	COG1668	transmembrane transport
HHK01_RS04665	COG0420	3'-5' exonuclease activity
HHK01_RS04675	COG3481	metal-dependent phosphohydrolase, HD sub domain
HHK01_RS04685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHK01_RS04715	COG1846	Transcriptional regulator
HHK01_RS04735	COG0537	adenosine 5'-monophosphoramidase activity
HHK01_RS04750	COG1396	sequence-specific DNA binding
HHK01_RS04755	COG3764	Sortase (surface protein transpeptidase)
HHK01_RS04760	COG1131	(ABC) transporter
HHK01_RS04765	COG4473	ABC transporter
HHK01_RS04775	COG1473	amidohydrolase
HHK01_RS04780	COG0671	phosphoesterase, PA-phosphatase related
HHK01_RS04790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS04795	COG3414	Phosphotransferase system galactitol-specific IIB component
HHK01_RS04800	COG3775	system Galactitol-specific IIC component
HHK01_RS04805	COG1063	alcohol dehydrogenase
HHK01_RS04810	COG1063	alcohol dehydrogenase
HHK01_RS04815	COG3069	C4-dicarboxylate transmembrane transporter activity
HHK01_RS04825	COG4585	Histidine kinase
HHK01_RS04830	COG2197	response regulator
HHK01_RS04835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHK01_RS04840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HHK01_RS04845	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HHK01_RS04855	COG0095	Lipoate-protein ligase
HHK01_RS04860	COG0318	PFAM AMP-dependent synthetase and ligase
HHK01_RS04865	COG1396	sequence-specific DNA binding
HHK01_RS04870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HHK01_RS04880	COG0501	Belongs to the peptidase M48B family
HHK01_RS04890	COG4903	ComK protein
HHK01_RS04895	COG1506	peptidase
HHK01_RS04895	COG4946	Tricorn protease homolog
HHK01_RS04895	COG0823	Involved in the tonB-independent uptake of proteins
HHK01_RS04900	COG0398	Pfam SNARE associated Golgi protein
HHK01_RS04910	COG2814	Major facilitator Superfamily
HHK01_RS04920	COG1074	ATP-dependent DNA helicase activity
HHK01_RS04955	COG2311	Membrane
HHK01_RS04965	COG3300	MHYT domain
HHK01_RS04965	COG5001	Diguanylate cyclase
HHK01_RS04975	COG0367	asparagine synthase
HHK01_RS04980	COG0534	Mate efflux family protein
HHK01_RS04990	COG2182	Extracellular solute-binding protein
HHK01_RS04995	COG1175	transmembrane transport
HHK01_RS05000	COG3833	ABC-type maltose transport systems, permease component
HHK01_RS05005	COG0366	Alpha amylase catalytic
HHK01_RS05005	COG1874	Beta-galactosidase
HHK01_RS05010	COG1609	Transcriptional regulator
HHK01_RS05020	COG1307	EDD domain protein, DegV family
HHK01_RS05025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHK01_RS05045	COG0561	phosphatase activity
HHK01_RS05050	COG1073	alpha beta
HHK01_RS05055	COG2151	metal-sulfur cluster biosynthetic enzyme
HHK01_RS05075	COG2267	carboxylic ester hydrolase activity
HHK01_RS05085	COG1744	ABC transporter substrate-binding protein PnrA-like
HHK01_RS05095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHK01_RS05100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHK01_RS05105	COG5504	Zn-dependent protease
HHK01_RS05115	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS05120	COG0601	transmembrane transport
HHK01_RS05140	COG0180	Tryptophanyl-tRNA synthetase
HHK01_RS05150	COG4166	transmembrane transport
HHK01_RS05155	COG0601	transmembrane transport
HHK01_RS05160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS05165	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS05170	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS05180	COG0456	acetyltransferase
HHK01_RS05190	COG1393	Belongs to the ArsC family
HHK01_RS05195	COG4862	establishment of competence for transformation
HHK01_RS05200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHK01_RS05210	COG1164	Oligoendopeptidase f
HHK01_RS05220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HHK01_RS05225	COG2346	COG2346, Truncated hemoglobins
HHK01_RS05245	COG2357	RelA SpoT domain protein
HHK01_RS05255	COG0564	pseudouridine synthase activity
HHK01_RS05260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HHK01_RS05265	COG2239	Acts as a magnesium transporter
HHK01_RS05270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHK01_RS05300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHK01_RS05310	COG2323	membrane
HHK01_RS05330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS05335	COG2153	protein acetylation
HHK01_RS05345	COG2382	esterase
HHK01_RS05350	COG2358	TRAP transporter, solute receptor (TAXI family
HHK01_RS05370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS05385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHK01_RS05395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHK01_RS05405	COG0861	Integral membrane protein TerC family
HHK01_RS05410	COG1191	sigma factor activity
HHK01_RS05425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHK01_RS05440	COG1032	radical SAM domain protein
HHK01_RS05445	COG3594	Acyltransferase
HHK01_RS05455	COG5002	protein histidine kinase activity
HHK01_RS05460	COG3339	Conserved Protein
HHK01_RS05470	COG3852	Histidine kinase
HHK01_RS05480	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HHK01_RS05490	COG3639	organic phosphonate transmembrane transporter activity
HHK01_RS05495	COG0737	Belongs to the 5'-nucleotidase family
HHK01_RS05500	COG1846	Transcriptional regulator
HHK01_RS05510	COG3949	Membrane
HHK01_RS05535	COG4873	Protein conserved in bacteria
HHK01_RS05550	COG3773	Cell wall hydrolase
HHK01_RS05570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHK01_RS05575	COG0436	Aminotransferase
HHK01_RS05580	COG0598	Magnesium transport protein CorA
HHK01_RS05585	COG2270	Major facilitator Superfamily
HHK01_RS05590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS05595	COG0784	Response regulator, receiver
HHK01_RS05595	COG0835	chemotaxis
HHK01_RS05610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHK01_RS05615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHK01_RS05620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHK01_RS05625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS05630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS05640	COG1033	growth of symbiont in host cell
HHK01_RS05640	COG2409	Drug exporters of the RND superfamily
HHK01_RS05655	COG1408	metallophosphoesterase
HHK01_RS05665	COG4990	cell redox homeostasis
HHK01_RS05685	COG0517	IMP dehydrogenase activity
HHK01_RS05690	COG0477	Major facilitator Superfamily
HHK01_RS05695	COG0583	DNA-binding transcription factor activity
HHK01_RS05700	COG2171	N-acyltransferase activity
HHK01_RS05705	COG1473	amidohydrolase
HHK01_RS05710	COG0668	transmembrane transport
HHK01_RS05715	COG0450	alkyl hydroperoxide reductase
HHK01_RS05720	COG1132	(ABC) transporter
HHK01_RS05725	COG1132	(ABC) transporter
HHK01_RS05730	COG1271	oxidase subunit
HHK01_RS05735	COG1294	oxidase, subunit
HHK01_RS05740	COG0569	domain protein
HHK01_RS05745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HHK01_RS05755	COG0561	phosphatase activity
HHK01_RS05765	COG0242	peptide deformylase activity
HHK01_RS05785	COG0022	dehydrogenase e1 component
HHK01_RS05805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHK01_RS05825	COG1982	Orn Lys Arg decarboxylase major
HHK01_RS05840	COG4493	Belongs to the UPF0637 family
HHK01_RS05850	COG0483	inositol monophosphate 1-phosphatase activity
HHK01_RS05860	COG1217	gtp-binding protein TYPA
HHK01_RS05870	COG4896	Protein conserved in bacteria
HHK01_RS05885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HHK01_RS05890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HHK01_RS05895	COG2066	Belongs to the glutaminase family
HHK01_RS05900	COG4838	Belongs to the UPF0358 family
HHK01_RS05905	COG0772	Belongs to the SEDS family
HHK01_RS05910	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HHK01_RS05915	COG1612	heme a metabolic process
HHK01_RS05920	COG0109	protoheme IX farnesyltransferase activity
HHK01_RS05945	COG3336	cytochrome c oxidase
HHK01_RS05955	COG0628	permease
HHK01_RS05970	COG2340	Cysteine-rich secretory protein family
HHK01_RS05995	COG3679	Belongs to the UPF0342 family
HHK01_RS06000	COG4471	UPF0298 protein
HHK01_RS06015	COG0742	ribosomal rna small subunit methyltransferase
HHK01_RS06020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HHK01_RS06025	COG3314	Sporulation integral membrane protein YlbJ
HHK01_RS06030	COG1752	Esterase of the alpha-beta hydrolase superfamily
HHK01_RS06035	COG3480	Lon protease (S16) C-terminal proteolytic domain
HHK01_RS06040	COG1323	Belongs to the UPF0348 family
HHK01_RS06045	COG1399	metal-binding, possibly nucleic acid-binding protein
HHK01_RS06050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HHK01_RS06060	COG1024	Enoyl-CoA hydratase
HHK01_RS06070	COG0454	-acetyltransferase
HHK01_RS06075	COG0439	Biotin carboxylase
HHK01_RS06080	COG4770	biotin carboxylase activity
HHK01_RS06085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHK01_RS06090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHK01_RS06100	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HHK01_RS06105	COG2001	Belongs to the MraZ family
HHK01_RS06115	COG4839	cell division protein FtsL
HHK01_RS06120	COG0768	penicillin binding
HHK01_RS06125	COG0768	penicillin binding
HHK01_RS06130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHK01_RS06135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHK01_RS06145	COG0772	Belongs to the SEDS family
HHK01_RS06150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HHK01_RS06155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHK01_RS06160	COG3879	Bacterial protein of unknown function (DUF881)
HHK01_RS06165	COG3879	Bacterial protein of unknown function (DUF881)
HHK01_RS06170	COG3856	small basic protein
HHK01_RS06175	COG0849	cell division
HHK01_RS06180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHK01_RS06195	COG1191	sigma factor activity
HHK01_RS06200	COG1191	sigma factor activity
HHK01_RS06205	COG1873	PFAM PRC-barrel domain
HHK01_RS06210	COG1496	oxidoreductase activity
HHK01_RS06215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHK01_RS06220	COG0762	integral membrane protein
HHK01_RS06225	COG2302	S4 RNA-binding domain
HHK01_RS06230	COG3599	regulation of cell shape
HHK01_RS06235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HHK01_RS06245	COG1556	Lactate utilization protein
HHK01_RS06265	COG1484	DNA-dependent DNA replication
HHK01_RS06275	COG1024	Enoyl-CoA hydratase
HHK01_RS06285	COG0247	lactate metabolic process
HHK01_RS06290	COG1139	Iron-sulfur cluster binding protein
HHK01_RS06295	COG1556	Lactate utilization protein
HHK01_RS06300	COG2610	gluconate transmembrane transporter activity
HHK01_RS06305	COG1929	Belongs to the glycerate kinase type-1 family
HHK01_RS06310	COG3835	regulator
HHK01_RS06320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HHK01_RS06325	COG0564	pseudouridine synthase activity
HHK01_RS06340	COG0540	Belongs to the ATCase OTCase family
HHK01_RS06345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHK01_RS06350	COG0505	Belongs to the CarA family
HHK01_RS06360	COG0543	2 iron, 2 sulfur cluster binding
HHK01_RS06365	COG0167	dihydroorotate dehydrogenase activity
HHK01_RS06370	COG0284	orotidine-5'-phosphate decarboxylase activity
HHK01_RS06380	COG4166	transmembrane transport
HHK01_RS06385	COG0601	transmembrane transport
HHK01_RS06390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS06395	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS06400	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS06410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HHK01_RS06415	COG1561	YicC-like family, N-terminal region
HHK01_RS06420	COG2052	Domain of unknown function (DUF370)
HHK01_RS06425	COG0194	GDP metabolic process
HHK01_RS06435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHK01_RS06440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHK01_RS06445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHK01_RS06450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHK01_RS06450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHK01_RS06455	COG0631	protein serine/threonine phosphatase activity
HHK01_RS06460	COG0515	serine threonine protein kinase
HHK01_RS06460	COG2815	serine threonine protein kinase
HHK01_RS06465	COG1162	GTPase activity
HHK01_RS06470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHK01_RS06475	COG1564	THIamine pyrophosphokinase
HHK01_RS06495	COG1302	Protein conserved in bacteria
HHK01_RS06500	COG1461	Dihydroxyacetone kinase
HHK01_RS06505	COG1760	l-serine dehydratase
HHK01_RS06510	COG1760	l-serine dehydratase
HHK01_RS06515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHK01_RS06520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHK01_RS06525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HHK01_RS06535	COG1349	DNA-binding transcription factor activity
HHK01_RS06540	COG0416	fatty acid biosynthetic process
HHK01_RS06545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHK01_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS06555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHK01_RS06560	COG0571	ribonuclease III activity
HHK01_RS06565	COG1196	nuclear chromosome segregation
HHK01_RS06575	COG0552	protein localization to endoplasmic reticulum
HHK01_RS06580	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HHK01_RS06585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHK01_RS06610	COG0228	four-way junction DNA binding
HHK01_RS06615	COG1837	Belongs to the UPF0109 family
HHK01_RS06625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHK01_RS06630	COG0336	Belongs to the RNA methyltransferase TrmD family
HHK01_RS06635	COG0335	large ribosomal subunit rRNA binding
HHK01_RS06645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HHK01_RS06655	COG0137	argininosuccinate synthase activity
HHK01_RS06660	COG0165	Argininosuccinate lyase
HHK01_RS06665	COG0505	Belongs to the CarA family
HHK01_RS06670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHK01_RS06675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHK01_RS06690	COG1111	helicase
HHK01_RS06690	COG1205	dead DEAH box helicase
HHK01_RS06695	COG3359	exonuclease
HHK01_RS06705	COG4474	Belongs to the UPF0398 family
HHK01_RS06710	COG3599	regulation of cell shape
HHK01_RS06720	COG0116	Belongs to the methyltransferase superfamily
HHK01_RS06730	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HHK01_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS06745	COG3424	synthase
HHK01_RS06750	COG1755	Isoprenylcysteine carboxyl methyltransferase
HHK01_RS06755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HHK01_RS06760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHK01_RS06770	COG0328	RNA-DNA hybrid ribonuclease activity
HHK01_RS06785	COG1278	Cold shock
HHK01_RS06790	COG1321	iron dependent repressor
HHK01_RS06800	COG2226	methyltransferase
HHK01_RS06815	COG1418	mRNA catabolic process
HHK01_RS06820	COG1413	lyase activity
HHK01_RS06835	COG2310	stress, protein
HHK01_RS06840	COG0861	Integral membrane protein TerC family
HHK01_RS06870	COG3853	Toxic anion resistance protein (TelA)
HHK01_RS06875	COG2310	stress, protein
HHK01_RS06880	COG2310	stress, protein
HHK01_RS06890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HHK01_RS06895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHK01_RS06920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHK01_RS06930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HHK01_RS06940	COG5278	phosphoserine phosphatase activity
HHK01_RS06940	COG0840	transmembrane signaling receptor activity
HHK01_RS06945	COG4479	Belongs to the UPF0346 family
HHK01_RS06985	COG0793	Belongs to the peptidase S41A family
HHK01_RS06985	COG3409	Peptidoglycan-binding domain 1 protein
HHK01_RS07000	COG1846	Transcriptional regulator
HHK01_RS07005	COG0477	Major facilitator Superfamily
HHK01_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS07050	COG0534	Mate efflux family protein
HHK01_RS07065	COG0586	Pfam SNARE associated Golgi protein
HHK01_RS07080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHK01_RS07080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHK01_RS07085	COG0307	riboflavin synthase, alpha
HHK01_RS07090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHK01_RS07090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHK01_RS07095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHK01_RS07100	COG3546	catalase activity
HHK01_RS07110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHK01_RS07115	COG1793	dna ligase
HHK01_RS07115	COG3285	dna ligase
HHK01_RS07120	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HHK01_RS07135	COG2814	Major facilitator Superfamily
HHK01_RS07145	COG0512	Glutamine amidotransferase of anthranilate synthase
HHK01_RS07150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHK01_RS07175	COG2226	methyltransferase
HHK01_RS07190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HHK01_RS07195	COG1984	allophanate hydrolase subunit 2
HHK01_RS07200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHK01_RS07205	COG0567	Dehydrogenase, E1 component
HHK01_RS07210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHK01_RS07215	COG1078	dGTPase activity
HHK01_RS07230	COG2153	protein acetylation
HHK01_RS07235	COG1523	belongs to the glycosyl hydrolase 13 family
HHK01_RS07245	COG0569	domain protein
HHK01_RS07245	COG0475	glutathione-regulated potassium exporter activity
HHK01_RS07250	COG0628	permease
HHK01_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS07260	COG0697	spore germination
HHK01_RS07315	COG2223	nitrite transmembrane transporter activity
HHK01_RS07320	COG0243	molybdopterin cofactor binding
HHK01_RS07325	COG3118	belongs to the thioredoxin family
HHK01_RS07330	COG0726	polysaccharide deacetylase
HHK01_RS07335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HHK01_RS07370	COG5577	PFAM Coat F domain
HHK01_RS07375	COG0697	spore germination
HHK01_RS07400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HHK01_RS07405	COG1138	Cytochrome C-type biogenesis protein
HHK01_RS07425	COG4555	ABC transporter
HHK01_RS07445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS07490	COG2132	Multicopper oxidase
HHK01_RS07495	COG1914	H( )-stimulated, divalent metal cation uptake system
HHK01_RS07505	COG5002	protein histidine kinase activity
HHK01_RS07510	COG0745	RESPONSE REGULATOR receiver
HHK01_RS07520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HHK01_RS07545	COG3850	Histidine kinase
HHK01_RS07545	COG5002	protein histidine kinase activity
HHK01_RS07550	COG0745	RESPONSE REGULATOR receiver
HHK01_RS07565	COG1280	lysine exporter protein (LysE YggA)
HHK01_RS07575	COG1733	regulation of RNA biosynthetic process
HHK01_RS07585	COG2814	Major facilitator Superfamily
HHK01_RS07595	COG4989	oxidoreductase activity
HHK01_RS07615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHK01_RS07620	COG0187	DNA topoisomerase II activity
HHK01_RS07625	COG1832	CoA-binding protein
HHK01_RS07630	COG2233	PERMEase
HHK01_RS07645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HHK01_RS07655	COG5002	protein histidine kinase activity
HHK01_RS07670	COG0824	Thioesterase
HHK01_RS07675	COG0464	growth
HHK01_RS07695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHK01_RS07715	COG2031	fatty acid transporter
HHK01_RS07725	COG1921	L-seryl-tRNASec selenium transferase activity
HHK01_RS07740	COG5146	pantothenate kinase activity
HHK01_RS07745	COG0419	ATPase involved in DNA repair
HHK01_RS07750	COG0420	3'-5' exonuclease activity
HHK01_RS07770	COG2188	Transcriptional regulator
HHK01_RS07775	COG0366	Alpha amylase catalytic
HHK01_RS07780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHK01_RS07780	COG1263	PTS System
HHK01_RS07795	COG4846	Membrane protein involved in cytochrome C biogenesis
HHK01_RS07800	COG2201	protein-glutamate methylesterase activity
HHK01_RS07805	COG0785	Cytochrome C biogenesis protein
HHK01_RS07815	COG3763	UPF0154 protein
HHK01_RS07830	COG4224	UPF0291 protein
HHK01_RS07835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHK01_RS07840	COG0174	glutamine synthetase
HHK01_RS07845	COG0789	Transcriptional regulator
HHK01_RS07850	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HHK01_RS07855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHK01_RS07860	COG2860	membrane
HHK01_RS07865	COG0464	growth
HHK01_RS07870	COG1923	regulation of RNA biosynthetic process
HHK01_RS07880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHK01_RS07885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHK01_RS07895	COG2755	lipolytic protein G-D-S-L family
HHK01_RS07910	COG1288	antiporter activity
HHK01_RS07930	COG0542	response to heat
HHK01_RS07945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHK01_RS07950	COG0583	DNA-binding transcription factor activity
HHK01_RS07965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHK01_RS07970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHK01_RS07995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS07995	COG3711	transcriptional antiterminator
HHK01_RS08000	COG2723	6-phospho-beta-galactosidase activity
HHK01_RS08010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHK01_RS08015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHK01_RS08035	COG2801	Transposase and inactivated derivatives
HHK01_RS08115	COG0492	ferredoxin-NADP+ reductase activity
HHK01_RS08120	COG2226	methyltransferase
HHK01_RS08160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHK01_RS08170	COG0438	transferase activity, transferring glycosyl groups
HHK01_RS08190	COG2165	general secretion pathway protein
HHK01_RS08195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHK01_RS08205	COG4464	protein tyrosine phosphatase activity
HHK01_RS08210	COG0489	protein tyrosine kinase activity
HHK01_RS08215	COG3944	biosynthesis protein
HHK01_RS08235	COG4550	Control of competence regulator ComK, YlbF/YmcA
HHK01_RS08240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHK01_RS08245	COG0156	8-amino-7-oxononanoate synthase activity
HHK01_RS08250	COG1063	alcohol dehydrogenase
HHK01_RS08260	COG2359	stage V sporulation protein S
HHK01_RS08265	COG1692	metallophosphoesterase
HHK01_RS08275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HHK01_RS08285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHK01_RS08290	COG1426	Protein conserved in bacteria
HHK01_RS08305	COG0300	oxidoreductase activity
HHK01_RS08310	COG0612	Peptidase, M16
HHK01_RS08315	COG0612	Peptidase, M16
HHK01_RS08340	COG1079	Belongs to the binding-protein-dependent transport system permease family
HHK01_RS08345	COG4603	Belongs to the binding-protein-dependent transport system permease family
HHK01_RS08350	COG3845	ABC transporter
HHK01_RS08355	COG1744	ABC transporter substrate-binding protein PnrA-like
HHK01_RS08360	COG2188	Transcriptional regulator
HHK01_RS08365	COG4980	gas vesicle protein
HHK01_RS08365	COG1674	ftsk spoiiie
HHK01_RS08375	COG0740	serine-type endopeptidase activity
HHK01_RS08380	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HHK01_RS08390	COG0527	aspartate kinase activity
HHK01_RS08395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHK01_RS08400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHK01_RS08405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHK01_RS08410	COG1873	PFAM PRC-barrel domain
HHK01_RS08415	COG0612	Peptidase, M16
HHK01_RS08420	COG0726	polysaccharide deacetylase
HHK01_RS08425	COG1185	polyribonucleotide nucleotidyltransferase activity
HHK01_RS08430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHK01_RS08435	COG0196	riboflavin kinase activity
HHK01_RS08440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HHK01_RS08445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HHK01_RS08450	COG1550	Protein conserved in bacteria
HHK01_RS08460	COG1358	cellular component organization or biogenesis
HHK01_RS08465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HHK01_RS08470	COG0195	Participates in both transcription termination and antitermination
HHK01_RS08475	COG0779	Required for maturation of 30S ribosomal subunits
HHK01_RS08480	COG2176	DNA-directed DNA polymerase activity
HHK01_RS08485	COG0442	prolyl-tRNA aminoacylation
HHK01_RS08490	COG0750	zinc metalloprotease
HHK01_RS08495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HHK01_RS08500	COG4589	Belongs to the CDS family
HHK01_RS08530	COG0528	UMP kinase activity
HHK01_RS08540	COG0052	Belongs to the universal ribosomal protein uS2 family
HHK01_RS08550	COG1191	sigma factor activity
HHK01_RS08555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HHK01_RS08560	COG1776	CheC inhibitor of MCP methylation
HHK01_RS08565	COG0835	chemotaxis
HHK01_RS08570	COG0643	Histidine kinase
HHK01_RS08570	COG2198	Histidine kinase
HHK01_RS08575	COG2201	protein-glutamate methylesterase activity
HHK01_RS08580	COG0455	bacterial-type flagellum organization
HHK01_RS08585	COG1419	protein localization to endoplasmic reticulum
HHK01_RS08590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HHK01_RS08595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HHK01_RS08600	COG1684	flagellar biosynthetic protein fliR
HHK01_RS08605	COG1987	bacterial-type flagellum assembly
HHK01_RS08610	COG1338	Plays a role in the flagellum-specific transport system
HHK01_RS08615	COG3190	flagellar
HHK01_RS08620	COG2201	protein-glutamate methylesterase activity
HHK01_RS08625	COG1776	CheC inhibitor of MCP methylation
HHK01_RS08625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HHK01_RS08630	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HHK01_RS08635	COG1580	Controls the rotational direction of flagella during chemotaxis
HHK01_RS08640	COG1582	Flagellar protein (FlbD)
HHK01_RS08655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HHK01_RS08670	COG2882	bacterial-type flagellum organization
HHK01_RS08675	COG1157	protein secretion by the type III secretion system
HHK01_RS08685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HHK01_RS08690	COG1766	The M ring may be actively involved in energy transduction
HHK01_RS08695	COG1677	Flagellar hook-basal body complex protein FliE
HHK01_RS08700	COG1558	bacterial-type flagellum-dependent cell motility
HHK01_RS08705	COG1815	bacterial-type flagellum-dependent cell motility
HHK01_RS08710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HHK01_RS08715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HHK01_RS08725	COG4974	Belongs to the 'phage' integrase family
HHK01_RS08730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HHK01_RS08735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHK01_RS08740	COG0758	DNA mediated transformation
HHK01_RS08745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHK01_RS08755	COG2257	FlhB HrpN YscU SpaS Family
HHK01_RS08795	COG3331	DNA recombination
HHK01_RS08800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHK01_RS08800	COG4499	WXG100 protein secretion system (Wss), protein YukC
HHK01_RS08810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHK01_RS08815	COG3935	DnaD domain protein
HHK01_RS08825	COG0436	Aminotransferase
HHK01_RS08830	COG5353	protein conserved in bacteria
HHK01_RS08840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHK01_RS08840	COG1199	ATP-dependent helicase activity
HHK01_RS08845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HHK01_RS08850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHK01_RS08855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HHK01_RS08870	COG0438	transferase activity, transferring glycosyl groups
HHK01_RS08875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHK01_RS08880	COG1803	Methylglyoxal synthase
HHK01_RS08890	COG1694	Mazg nucleotide pyrophosphohydrolase
HHK01_RS08895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHK01_RS08900	COG2738	Putative neutral zinc metallopeptidase
HHK01_RS08910	COG4347	Protein of unknown function (DUF1405)
HHK01_RS08915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HHK01_RS08915	COG2010	Cytochrome c
HHK01_RS08920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HHK01_RS08940	COG2608	mercury ion transmembrane transporter activity
HHK01_RS08950	COG2217	Heavy metal translocating P-type atpase
HHK01_RS08960	COG5582	Belongs to the UPF0302 family
HHK01_RS08965	COG0457	Tetratricopeptide repeat
HHK01_RS08975	COG0287	Prephenate dehydrogenase
HHK01_RS08980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHK01_RS08990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHK01_RS08995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHK01_RS09000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HHK01_RS09010	COG0142	geranyltranstransferase activity
HHK01_RS09015	COG2226	methyltransferase
HHK01_RS09020	COG0142	geranyltranstransferase activity
HHK01_RS09045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HHK01_RS09065	COG1160	GTP binding
HHK01_RS09090	COG1304	FMN binding
HHK01_RS09095	COG0539	negative regulation of cytoplasmic translation
HHK01_RS09100	COG0204	Acyl-transferase
HHK01_RS09105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HHK01_RS09115	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HHK01_RS09120	COG2959	enzyme of heme biosynthesis
HHK01_RS09125	COG3409	Peptidoglycan-binding domain 1 protein
HHK01_RS09125	COG3773	Cell wall hydrolase
HHK01_RS09130	COG2339	peptidase activity
HHK01_RS09140	COG0492	ferredoxin-NADP+ reductase activity
HHK01_RS09145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHK01_RS09150	COG4862	establishment of competence for transformation
HHK01_RS09155	COG1408	metallophosphoesterase
HHK01_RS09165	COG0514	ATP-dependent DNA helicase (RecQ)
HHK01_RS09170	COG4955	Helix-turn-helix domain
HHK01_RS09175	COG1141	Ferredoxin
HHK01_RS09190	COG1595	DNA-templated transcription, initiation
HHK01_RS09205	COG5002	protein histidine kinase activity
HHK01_RS09210	COG0745	RESPONSE REGULATOR receiver
HHK01_RS09215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHK01_RS09220	COG1333	cytochrome c biogenesis protein
HHK01_RS09225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS09230	COG1187	pseudouridine synthase activity
HHK01_RS09235	COG0700	Nucleoside recognition
HHK01_RS09240	COG2715	membrane protein required for spore maturation
HHK01_RS09245	COG1686	Belongs to the peptidase S11 family
HHK01_RS09255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HHK01_RS09260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HHK01_RS09265	COG1547	Domain of unknown function (DUF309)
HHK01_RS09275	COG0019	diaminopimelate decarboxylase activity
HHK01_RS09280	COG0697	spore germination
HHK01_RS09315	COG1686	Belongs to the peptidase S11 family
HHK01_RS09325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHK01_RS09335	COG4974	Belongs to the 'phage' integrase family
HHK01_RS09365	COG0735	belongs to the Fur family
HHK01_RS09370	COG1300	Membrane
HHK01_RS09375	COG1379	DNA repair
HHK01_RS09390	COG0667	Aldo Keto reductase
HHK01_RS09395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HHK01_RS09400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HHK01_RS09405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHK01_RS09410	COG1073	alpha beta
HHK01_RS09430	COG4721	ABC-type cobalt transport system, permease component
HHK01_RS09435	COG1122	ATPase activity
HHK01_RS09440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HHK01_RS09445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHK01_RS09465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHK01_RS09495	COG0659	secondary active sulfate transmembrane transporter activity
HHK01_RS09515	COG0300	oxidoreductase activity
HHK01_RS09520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS09525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHK01_RS09530	COG1902	pentaerythritol trinitrate reductase activity
HHK01_RS09540	COG1234	tRNA 3'-trailer cleavage
HHK01_RS09545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHK01_RS09550	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HHK01_RS09555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHK01_RS09565	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHK01_RS09570	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS09575	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS09580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS09585	COG0601	transmembrane transport
HHK01_RS09600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHK01_RS09615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHK01_RS09620	COG0346	lactoylglutathione lyase activity
HHK01_RS09630	COG1376	ErfK ybiS ycfS ynhG family protein
HHK01_RS09635	COG4129	membrane
HHK01_RS09640	COG1126	abc transporter atp-binding protein
HHK01_RS09645	COG0765	amino acid transport
HHK01_RS09650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHK01_RS09665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHK01_RS09665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHK01_RS09670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHK01_RS09675	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHK01_RS09680	COG0022	dehydrogenase e1 component
HHK01_RS09685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHK01_RS09690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHK01_RS09695	COG3426	butyrate kinase activity
HHK01_RS09705	COG0280	phosphate acetyltransferase
HHK01_RS09710	COG3290	protein histidine kinase activity
HHK01_RS09710	COG3829	transcription factor binding
HHK01_RS09720	COG0584	glycerophosphoryl diester phosphodiesterase
HHK01_RS09725	COG0745	RESPONSE REGULATOR receiver
HHK01_RS09730	COG0750	zinc metalloprotease
HHK01_RS09735	COG0497	DNA recombination
HHK01_RS09740	COG1438	arginine binding
HHK01_RS09745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HHK01_RS09750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HHK01_RS09765	COG1722	exodeoxyribonuclease VII activity
HHK01_RS09770	COG1570	exodeoxyribonuclease VII activity
HHK01_RS09785	COG1302	Protein conserved in bacteria
HHK01_RS09790	COG0439	Biotin carboxylase
HHK01_RS09795	COG0511	ligase activity, forming carbon-carbon bonds
HHK01_RS09835	COG3854	ATPases associated with a variety of cellular activities
HHK01_RS09840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HHK01_RS09845	COG0006	proline dipeptidase activity
HHK01_RS09850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HHK01_RS09865	COG1752	Esterase of the alpha-beta hydrolase superfamily
HHK01_RS09870	COG0716	FMN binding
HHK01_RS09875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHK01_RS09880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHK01_RS09885	COG0095	Lipoate-protein ligase
HHK01_RS09890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHK01_RS09895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHK01_RS09900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHK01_RS09905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HHK01_RS09910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHK01_RS09925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHK01_RS09950	COG4537	Required for transformation and DNA binding
HHK01_RS09960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHK01_RS09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS10020	COG1368	sulfuric ester hydrolase activity
HHK01_RS10025	COG1940	carbohydrate kinase activity
HHK01_RS10035	COG0697	spore germination
HHK01_RS10045	COG0705	Rhomboid family
HHK01_RS10045	COG0457	Tetratricopeptide repeat
HHK01_RS10055	COG1836	PFAM Integral membrane protein DUF92
HHK01_RS10060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHK01_RS10065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHK01_RS10075	COG0438	transferase activity, transferring glycosyl groups
HHK01_RS10095	COG0704	Plays a role in the regulation of phosphate uptake
HHK01_RS10100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHK01_RS10105	COG0581	inorganic phosphate transmembrane transporter activity
HHK01_RS10120	COG0768	penicillin binding
HHK01_RS10125	COG0477	Major facilitator Superfamily
HHK01_RS10135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HHK01_RS10140	COG2839	Protein conserved in bacteria
HHK01_RS10145	COG1283	sodium-dependent phosphate transmembrane transporter activity
HHK01_RS10150	COG5521	maltodextrose utilization protein MalA
HHK01_RS10155	COG1388	LysM domain
HHK01_RS10160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHK01_RS10165	COG4709	membrane
HHK01_RS10170	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HHK01_RS10175	COG0735	belongs to the Fur family
HHK01_RS10180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHK01_RS10185	COG1121	(ABC) transporter
HHK01_RS10190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHK01_RS10200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HHK01_RS10205	COG0513	Belongs to the DEAD box helicase family
HHK01_RS10215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HHK01_RS10220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HHK01_RS10225	COG2384	SAM-dependent methyltransferase
HHK01_RS10230	COG2010	Cytochrome c
HHK01_RS10235	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS10240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHK01_RS10245	COG0358	DNA primase activity
HHK01_RS10250	COG1671	Belongs to the UPF0178 family
HHK01_RS10255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHK01_RS10260	COG0517	IMP dehydrogenase activity
HHK01_RS10270	COG0752	glycyl-tRNA synthetase alpha subunit
HHK01_RS10275	COG1381	Involved in DNA repair and RecF pathway recombination
HHK01_RS10290	COG0295	cytidine deaminase activity
HHK01_RS10295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHK01_RS10305	COG1480	7TM receptor with intracellular HD hydrolase
HHK01_RS10310	COG1702	phosphate starvation-inducible protein PhoH
HHK01_RS10330	COG4864	UPF0365 protein
HHK01_RS10335	COG1030	water channel activity
HHK01_RS10340	COG1610	YqeY-like protein
HHK01_RS10350	COG1283	sodium-dependent phosphate transmembrane transporter activity
HHK01_RS10355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HHK01_RS10360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHK01_RS10365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHK01_RS10370	COG2264	protein methyltransferase activity
HHK01_RS10375	COG0484	heat shock protein binding
HHK01_RS10380	COG0443	Heat shock 70 kDa protein
HHK01_RS10390	COG1420	regulation of RNA biosynthetic process
HHK01_RS10410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHK01_RS10415	COG0481	GTPase activity
HHK01_RS10425	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHK01_RS10440	COG1466	dna polymerase III delta subunit
HHK01_RS10450	COG2333	competence protein COMEC
HHK01_RS10450	COG0658	competence protein
HHK01_RS10455	COG2131	deaminase
HHK01_RS10460	COG1555	photosystem II stabilization
HHK01_RS10460	COG1596	polysaccharide export
HHK01_RS10465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHK01_RS10470	COG2226	methyltransferase
HHK01_RS10475	COG0799	negative regulation of ribosome biogenesis
HHK01_RS10480	COG1713	HD superfamily hydrolase involved in NAD metabolism
HHK01_RS10485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HHK01_RS10490	COG1534	Rna-binding protein
HHK01_RS10500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HHK01_RS10505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HHK01_RS10550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHK01_RS10560	COG0768	penicillin binding
HHK01_RS10565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HHK01_RS10570	COG0572	uridine kinase
HHK01_RS10575	COG4122	O-methyltransferase activity
HHK01_RS10580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHK01_RS10585	COG3906	Belongs to the UPF0473 family
HHK01_RS10595	COG4472	Bacterial protein of unknown function (DUF965)
HHK01_RS10600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHK01_RS10605	COG0628	permease
HHK01_RS10615	COG3881	PFAM PRC-barrel domain
HHK01_RS10620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHK01_RS10630	COG0482	sulfurtransferase activity
HHK01_RS10635	COG1104	cysteine desulfurase activity
HHK01_RS10640	COG1959	2 iron, 2 sulfur cluster binding
HHK01_RS10645	COG2364	Membrane
HHK01_RS10650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHK01_RS10655	COG0840	transmembrane signaling receptor activity
HHK01_RS10660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HHK01_RS10665	COG1131	(ABC) transporter
HHK01_RS10675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HHK01_RS10680	COG0124	histidyl-tRNA synthetase
HHK01_RS10695	COG1490	D-aminoacyl-tRNA deacylase activity
HHK01_RS10700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHK01_RS10705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHK01_RS10710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHK01_RS10710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHK01_RS10715	COG5416	Lipopolysaccharide assembly protein A domain
HHK01_RS10720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHK01_RS10720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHK01_RS10730	COG2244	polysaccharide biosynthetic process
HHK01_RS10735	COG2323	membrane
HHK01_RS10745	COG1862	Preprotein translocase
HHK01_RS10750	COG0343	queuine tRNA-ribosyltransferase activity
HHK01_RS10755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HHK01_RS10765	COG2255	four-way junction helicase activity
HHK01_RS10770	COG0632	four-way junction helicase activity
HHK01_RS10785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HHK01_RS10800	COG1827	regulation of RNA biosynthetic process
HHK01_RS10805	COG0077	Prephenate dehydratase
HHK01_RS10810	COG4492	Belongs to the UPF0735 family
HHK01_RS10815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHK01_RS10820	COG3290	protein histidine kinase activity
HHK01_RS10825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHK01_RS10830	COG2868	ribosomal protein
HHK01_RS10835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HHK01_RS10845	COG1994	Peptidase M50
HHK01_RS10850	COG0739	heme binding
HHK01_RS10855	COG2894	cell division
HHK01_RS10860	COG0850	regulation of cytokinetic process
HHK01_RS10865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HHK01_RS10870	COG1792	Involved in formation and maintenance of cell shape
HHK01_RS10875	COG1077	Cell shape determining protein MreB Mrl
HHK01_RS10880	COG2003	Belongs to the UPF0758 family
HHK01_RS10910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HHK01_RS10920	COG1459	type II secretion system
HHK01_RS10930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHK01_RS10955	COG0285	dihydrofolate synthase activity
HHK01_RS10960	COG0525	valine-tRNA ligase activity
HHK01_RS10975	COG1388	LysM domain
HHK01_RS10975	COG1388	LysM domain
HHK01_RS10980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHK01_RS10985	COG0113	porphobilinogen synthase activity
HHK01_RS10995	COG0181	hydroxymethylbilane synthase activity
HHK01_RS11000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHK01_RS11015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HHK01_RS11020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHK01_RS11025	COG1067	ATP-dependent peptidase activity
HHK01_RS11025	COG0470	DNA polymerase III
HHK01_RS11030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HHK01_RS11035	COG0544	peptidyl-prolyl cis-trans isomerase activity
HHK01_RS11040	COG0457	Tetratricopeptide repeat
HHK01_RS11040	COG1477	protein flavinylation
HHK01_RS11060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HHK01_RS11065	COG5401	PFAM Sporulation and spore germination
HHK01_RS11075	COG1846	Transcriptional regulator
HHK01_RS11080	COG2197	response regulator
HHK01_RS11085	COG0824	Thioesterase
HHK01_RS11090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHK01_RS11095	COG1053	succinate dehydrogenase
HHK01_RS11100	COG2009	succinate dehydrogenase
HHK01_RS11115	COG0322	excinuclease ABC activity
HHK01_RS11120	COG3118	belongs to the thioredoxin family
HHK01_RS11125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HHK01_RS11130	COG2086	electron transfer activity
HHK01_RS11135	COG1024	Enoyl-CoA hydratase
HHK01_RS11140	COG1309	transcriptional regulator
HHK01_RS11145	COG0318	PFAM AMP-dependent synthetase and ligase
HHK01_RS11150	COG3766	membrane
HHK01_RS11155	COG1193	negative regulation of DNA recombination
HHK01_RS11160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHK01_RS11160	COG1796	DNA polymerase
HHK01_RS11165	COG1286	toxin biosynthetic process
HHK01_RS11170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HHK01_RS11175	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHK01_RS11180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHK01_RS11180	COG0072	phenylalanine-tRNA ligase activity
HHK01_RS11185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HHK01_RS11190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHK01_RS11210	COG1476	TRANSCRIPTIONal
HHK01_RS11215	COG1363	Peptidase, m42
HHK01_RS11225	COG3326	Membrane
HHK01_RS11230	COG0488	(ABC) transporter
HHK01_RS11235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHK01_RS11245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HHK01_RS11260	COG1484	DNA-dependent DNA replication
HHK01_RS11265	COG3611	Membrane attachment protein
HHK01_RS11270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHK01_RS11280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHK01_RS11285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HHK01_RS11290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHK01_RS11300	COG1971	Probably functions as a manganese efflux pump
HHK01_RS11305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHK01_RS11310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHK01_RS11310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHK01_RS11315	COG5002	protein histidine kinase activity
HHK01_RS11320	COG0745	RESPONSE REGULATOR receiver
HHK01_RS11330	COG4948	Mandelate Racemase Muconate Lactonizing
HHK01_RS11350	COG3493	citrate carrier protein
HHK01_RS11355	COG0473	3-isopropylmalate dehydrogenase activity
HHK01_RS11360	COG1802	Transcriptional regulator
HHK01_RS11375	COG0538	isocitrate dehydrogenase activity
HHK01_RS11380	COG0372	Belongs to the citrate synthase family
HHK01_RS11385	COG2707	UPF0756 membrane protein
HHK01_RS11390	COG0628	permease
HHK01_RS11395	COG3030	protein affecting phage T7 exclusion by the F plasmid
HHK01_RS11405	COG0205	6-phosphofructokinase activity
HHK01_RS11410	COG0825	malonyl-CoA metabolic process
HHK01_RS11415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HHK01_RS11420	COG1725	Transcriptional regulator
HHK01_RS11425	COG0281	malic enzyme
HHK01_RS11430	COG0587	DNA-directed DNA polymerase activity
HHK01_RS11445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHK01_RS11455	COG4109	DRTGG domain
HHK01_RS11465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HHK01_RS11470	COG0006	proline dipeptidase activity
HHK01_RS11485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HHK01_RS11490	COG0827	DNA restriction-modification system
HHK01_RS11495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HHK01_RS11500	COG3874	Sporulation protein YtfJ
HHK01_RS11510	COG1714	RDD family
HHK01_RS11515	COG0616	signal peptide processing
HHK01_RS11520	COG2962	Rard protein
HHK01_RS11525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HHK01_RS11530	COG0840	transmembrane signaling receptor activity
HHK01_RS11535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHK01_RS11545	COG0301	tRNA thio-modification
HHK01_RS11550	COG1104	cysteine desulfurase activity
HHK01_RS11555	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HHK01_RS11560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHK01_RS11565	COG1309	transcriptional regulator
HHK01_RS11570	COG1956	GAF domain-containing protein
HHK01_RS11575	COG2199	diguanylate cyclase activity
HHK01_RS11575	COG2203	Gaf domain
HHK01_RS11580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHK01_RS11585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHK01_RS11590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHK01_RS11595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHK01_RS11600	COG0454	-acetyltransferase
HHK01_RS11605	COG0517	IMP dehydrogenase activity
HHK01_RS11610	COG0123	including yeast histone deacetylase and acetoin utilization protein
HHK01_RS11620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HHK01_RS11630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HHK01_RS11630	COG1605	Chorismate mutase
HHK01_RS11635	COG0849	cell division
HHK01_RS11640	COG4980	gas vesicle protein
HHK01_RS11650	COG2309	aminopeptidase activity
HHK01_RS11655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHK01_RS11670	COG1674	ftsk spoiiie
HHK01_RS11675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHK01_RS11680	COG4848	Belongs to the UPF0354 family
HHK01_RS11685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS11710	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HHK01_RS11715	COG1363	Peptidase, m42
HHK01_RS11730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS11735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHK01_RS11745	COG0510	thiamine kinase activity
HHK01_RS11755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHK01_RS11770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHK01_RS11775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHK01_RS11780	COG1349	DNA-binding transcription factor activity
HHK01_RS11785	COG1187	pseudouridine synthase activity
HHK01_RS11790	COG2244	polysaccharide biosynthetic process
HHK01_RS11795	COG2081	HI0933 family
HHK01_RS11805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHK01_RS11810	COG0495	leucyl-tRNA aminoacylation
HHK01_RS11820	COG2814	Major facilitator Superfamily
HHK01_RS11835	COG1242	4 iron, 4 sulfur cluster binding
HHK01_RS11840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HHK01_RS11850	COG2267	carboxylic ester hydrolase activity
HHK01_RS11855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HHK01_RS11865	COG0367	asparagine synthase
HHK01_RS11870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HHK01_RS11880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HHK01_RS11895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHK01_RS11900	COG1116	anion transmembrane transporter activity
HHK01_RS11905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHK01_RS11910	COG1840	ABC-type Fe3 transport system, periplasmic component
HHK01_RS11915	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHK01_RS11920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HHK01_RS11925	COG1263	PTS System
HHK01_RS11925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHK01_RS11930	COG0494	nUDIX hydrolase
HHK01_RS11955	COG0783	Belongs to the Dps family
HHK01_RS11965	COG1854	S-ribosylhomocysteine lyase activity
HHK01_RS11970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHK01_RS11980	COG4948	Mandelate Racemase Muconate Lactonizing
HHK01_RS11985	COG0318	PFAM AMP-dependent synthetase and ligase
HHK01_RS11990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHK01_RS11995	COG0596	Alpha beta hydrolase
HHK01_RS12000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HHK01_RS12005	COG1169	isochorismate synthase
HHK01_RS12010	COG1575	Belongs to the MenA family. Type 1 subfamily
HHK01_RS12015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHK01_RS12020	COG0058	SHG alpha-glucan phosphorylase activity
HHK01_RS12025	COG0297	glycogen (starch) synthase activity
HHK01_RS12035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HHK01_RS12045	COG0730	response to heat
HHK01_RS12150	COG1247	-acetyltransferase
HHK01_RS12155	COG1285	pathogenesis
HHK01_RS12165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HHK01_RS12175	COG0166	Belongs to the GPI family
HHK01_RS12180	COG1979	alcohol dehydrogenase
HHK01_RS12185	COG2155	Conserved Protein
HHK01_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
HHK01_RS12195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHK01_RS12200	COG1098	S1 RNA binding domain
HHK01_RS12215	COG2032	superoxide dismutase activity
HHK01_RS12235	COG2814	Major facilitator Superfamily
HHK01_RS12245	COG2111	Na H antiporter
HHK01_RS12245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHK01_RS12250	COG2111	Na H antiporter
HHK01_RS12255	COG1006	Multisubunit Na H antiporter MnhC subunit
HHK01_RS12260	COG0651	ATP synthesis coupled electron transport
HHK01_RS12265	COG1863	multisubunit Na H antiporter MnhE subunit
HHK01_RS12270	COG2212	antiporter activity
HHK01_RS12275	COG1320	monovalent cation:proton antiporter activity
HHK01_RS12280	COG2050	protein possibly involved in aromatic compounds catabolism
HHK01_RS12295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHK01_RS12300	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HHK01_RS12305	COG3584	3D domain protein
HHK01_RS12325	COG1252	NADH dehydrogenase
HHK01_RS12330	COG0492	ferredoxin-NADP+ reductase activity
HHK01_RS12335	COG0316	Belongs to the HesB IscA family
HHK01_RS12340	COG4844	belongs to the
HHK01_RS12345	COG1252	NADH dehydrogenase
HHK01_RS12350	COG4837	Protein of unknown function (DUF1462)
HHK01_RS12360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHK01_RS12365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HHK01_RS12370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHK01_RS12375	COG0647	UMP catabolic process
HHK01_RS12380	COG2445	Protein of unknown function DUF86
HHK01_RS12390	COG4470	Protein conserved in bacteria
HHK01_RS12405	COG0739	heme binding
HHK01_RS12415	COG0733	neurotransmitter:sodium symporter activity
HHK01_RS12420	COG1757	Na H antiporter
HHK01_RS12430	COG3377	Domain of unknown function (DUF1805)
HHK01_RS12435	COG0737	Belongs to the 5'-nucleotidase family
HHK01_RS12440	COG0719	Fe-S assembly protein
HHK01_RS12445	COG0822	iron-sulfur transferase activity
HHK01_RS12450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHK01_RS12455	COG0719	Fe-S assembly protein
HHK01_RS12460	COG0396	ATPase activity
HHK01_RS12470	COG1464	Belongs to the NlpA lipoprotein family
HHK01_RS12475	COG2011	ABC-type metal ion transport system permease component
HHK01_RS12480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHK01_RS12495	COG1174	glycine betaine transport
HHK01_RS12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHK01_RS12505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS12515	COG0509	glycine decarboxylation via glycine cleavage system
HHK01_RS12520	COG1393	Belongs to the ArsC family
HHK01_RS12525	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS12530	COG0183	Belongs to the thiolase family
HHK01_RS12535	COG1024	Enoyl-CoA hydratase
HHK01_RS12535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHK01_RS12560	COG1120	ATPase activity
HHK01_RS12575	COG1120	ATPase activity
HHK01_RS12580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS12585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHK01_RS12590	COG2070	2-Nitropropane dioxygenase
HHK01_RS12595	COG4086	secreted protein
HHK01_RS12605	COG3973	AAA domain
HHK01_RS12610	COG1666	GTP binding
HHK01_RS12615	COG1742	UPF0060 membrane protein
HHK01_RS12620	COG0488	(ABC) transporter
HHK01_RS12630	COG1012	belongs to the aldehyde dehydrogenase family
HHK01_RS12635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHK01_RS12640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHK01_RS12645	COG0640	Transcriptional regulator
HHK01_RS12650	COG2076	Multidrug Resistance protein
HHK01_RS12655	COG2076	Multidrug Resistance protein
HHK01_RS12660	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HHK01_RS12670	COG2112	serine threonine protein kinase
HHK01_RS12675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHK01_RS12705	COG4149	molybdate abc transporter
HHK01_RS12710	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHK01_RS12715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HHK01_RS12720	COG0314	molybdopterin synthase activity
HHK01_RS12725	COG1763	Mo-molybdopterin cofactor biosynthetic process
HHK01_RS12730	COG0303	'Molybdopterin
HHK01_RS12735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHK01_RS12745	COG0746	molybdenum cofactor guanylyltransferase activity
HHK01_RS12755	COG2116	formate transmembrane transporter activity
HHK01_RS12765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HHK01_RS12770	COG5609	conserved protein (DUF2294)
HHK01_RS12775	COG3383	formate dehydrogenase (NAD+) activity
HHK01_RS12780	COG2427	Protein of unknown function (DUF1641)
HHK01_RS12785	COG0489	protein tyrosine kinase activity
HHK01_RS12805	COG3383	formate dehydrogenase (NAD+) activity
HHK01_RS12810	COG2116	formate transmembrane transporter activity
HHK01_RS12820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHK01_RS12825	COG1966	Carbon starvation protein
HHK01_RS12835	COG3275	phosphorelay sensor kinase activity
HHK01_RS12840	COG0028	Belongs to the TPP enzyme family
HHK01_RS12855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHK01_RS12860	COG0557	exoribonuclease II activity
HHK01_RS12865	COG1647	Serine aminopeptidase, S33
HHK01_RS12870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHK01_RS12875	COG0148	phosphopyruvate hydratase activity
HHK01_RS12885	COG0149	triose-phosphate isomerase activity
HHK01_RS12890	COG0126	phosphoglycerate kinase activity
HHK01_RS12895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHK01_RS12910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HHK01_RS12920	COG0740	serine-type endopeptidase activity
HHK01_RS12925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS12930	COG1481	regulation of sporulation
HHK01_RS12935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HHK01_RS12940	COG1660	Displays ATPase and GTPase activities
HHK01_RS12945	COG1051	belongs to the nudix hydrolase family
HHK01_RS12950	COG0492	ferredoxin-NADP+ reductase activity
HHK01_RS12955	COG0457	Tetratricopeptide repeat
HHK01_RS12960	COG1876	peptidase activity
HHK01_RS12965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HHK01_RS12965	COG0140	phosphoribosyl-ATP diphosphatase activity
HHK01_RS12970	COG0107	imidazoleglycerol-phosphate synthase activity
HHK01_RS12975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HHK01_RS12980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HHK01_RS12985	COG0131	Imidazoleglycerol-phosphate dehydratase
HHK01_RS12990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHK01_RS12995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHK01_RS13000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HHK01_RS13005	COG0110	maltose O-acetyltransferase activity
HHK01_RS13015	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HHK01_RS13025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HHK01_RS13030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHK01_RS13035	COG0363	glucosamine-6-phosphate deaminase activity
HHK01_RS13045	COG3595	metallopeptidase activity
HHK01_RS13055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHK01_RS13065	COG4897	Protein conserved in bacteria
HHK01_RS13070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHK01_RS13075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHK01_RS13080	COG3409	Peptidoglycan-binding domain 1 protein
HHK01_RS13080	COG0793	Belongs to the peptidase S41A family
HHK01_RS13090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHK01_RS13095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHK01_RS13105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHK01_RS13120	COG0626	cystathionine gamma-synthase activity
HHK01_RS13125	COG0791	NLP P60 protein
HHK01_RS13125	COG3883	PFAM NLP P60 protein
HHK01_RS13130	COG2177	Part of the ABC transporter FtsEX involved in
HHK01_RS13135	COG2884	Cell division ATP-binding protein ftsE
HHK01_RS13150	COG0653	protein targeting
HHK01_RS13160	COG2059	Chromate
HHK01_RS13165	COG2059	Chromate
HHK01_RS13170	COG0405	Gamma-glutamyltransferase
HHK01_RS13175	COG4608	Belongs to the ABC transporter superfamily
HHK01_RS13180	COG0444	Belongs to the ABC transporter superfamily
HHK01_RS13185	COG0747	negative chemotaxis
HHK01_RS13190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHK01_RS13195	COG0601	transmembrane transport
HHK01_RS13200	COG1522	sequence-specific DNA binding
HHK01_RS13215	COG1516	flagellar protein fliS
HHK01_RS13220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HHK01_RS13235	COG1017	nitric oxide dioxygenase activity
HHK01_RS13235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HHK01_RS13240	COG1959	2 iron, 2 sulfur cluster binding
HHK01_RS13250	COG4821	SIS domain
HHK01_RS13260	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HHK01_RS13320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HHK01_RS13325	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HHK01_RS13335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HHK01_RS13340	COG1256	bacterial-type flagellum assembly
HHK01_RS13340	COG4786	Flagellar basal body rod
HHK01_RS13350	COG2747	anti-sigma28 factor FlgM
HHK01_RS13370	COG1040	competence protein
HHK01_RS13375	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HHK01_RS13380	COG1307	EDD domain protein, DegV family
HHK01_RS13385	COG2197	response regulator
HHK01_RS13395	COG1739	Uncharacterized protein family UPF0029
HHK01_RS13400	COG1316	TRANSCRIPTIONal
HHK01_RS13405	COG1316	TRANSCRIPTIONal
HHK01_RS13410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHK01_RS13415	COG0653	protein targeting
HHK01_RS13430	COG0737	Belongs to the 5'-nucleotidase family
HHK01_RS13430	COG4085	toxin activity
HHK01_RS13430	COG1525	nuclease
HHK01_RS13470	COG1879	ABC-type sugar transport system periplasmic component
HHK01_RS13475	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHK01_RS13480	COG1129	ABC transporter
HHK01_RS13485	COG1869	D-ribose catabolic process
HHK01_RS13490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHK01_RS13495	COG1609	Transcriptional regulator
HHK01_RS13505	COG0840	transmembrane signaling receptor activity
HHK01_RS13510	COG2201	protein-glutamate methylesterase activity
HHK01_RS13540	COG0402	S-adenosylhomocysteine deaminase activity
HHK01_RS13545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHK01_RS13570	COG0438	transferase activity, transferring glycosyl groups
HHK01_RS13575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHK01_RS13585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHK01_RS13595	COG0438	transferase activity, transferring glycosyl groups
HHK01_RS13600	COG0728	peptidoglycan biosynthetic process
HHK01_RS13620	COG0791	NLP P60 protein
HHK01_RS13625	COG1404	Belongs to the peptidase S8 family
HHK01_RS13655	COG1785	Belongs to the alkaline phosphatase family
HHK01_RS13670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHK01_RS13685	COG0629	single-stranded DNA binding
HHK01_RS13695	COG1228	amidohydrolase
HHK01_RS13720	COG0514	ATP-dependent DNA helicase (RecQ)
HHK01_RS13725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHK01_RS13735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHK01_RS13740	COG0765	amino acid transport
HHK01_RS13745	COG1126	abc transporter atp-binding protein
HHK01_RS13750	COG3314	Sporulation integral membrane protein YlbJ
HHK01_RS13760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HHK01_RS13765	COG0602	queuosine metabolic process
HHK01_RS13770	COG0720	synthase
HHK01_RS13775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHK01_RS13780	COG0346	lactoylglutathione lyase activity
HHK01_RS13785	COG0400	carboxylic ester hydrolase activity
HHK01_RS13795	COG0318	PFAM AMP-dependent synthetase and ligase
HHK01_RS13800	COG2226	methyltransferase
HHK01_RS13805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HHK01_RS13810	COG0626	cystathionine gamma-synthase activity
HHK01_RS13815	COG2356	endonuclease I
HHK01_RS13825	COG1525	nuclease
HHK01_RS13825	COG4085	toxin activity
HHK01_RS13825	COG0737	Belongs to the 5'-nucleotidase family
HHK01_RS13855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHK01_RS13865	COG4786	Flagellar basal body rod
HHK01_RS13870	COG4786	Flagellar basal body rod
HHK01_RS13875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HHK01_RS13880	COG2244	polysaccharide biosynthetic process
HHK01_RS13885	COG1077	Cell shape determining protein MreB Mrl
HHK01_RS13890	COG1609	Transcriptional regulator
HHK01_RS13910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHK01_RS13920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HHK01_RS13925	COG1999	signal sequence binding
HHK01_RS13930	COG0739	heme binding
HHK01_RS13935	COG2385	sporulation resulting in formation of a cellular spore
HHK01_RS13940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHK01_RS13945	COG4836	Membrane
HHK01_RS13955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHK01_RS13960	COG1131	(ABC) transporter
HHK01_RS13975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HHK01_RS13980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHK01_RS13985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHK01_RS13990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HHK01_RS13995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHK01_RS14000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HHK01_RS14005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHK01_RS14010	COG0356	it plays a direct role in the translocation of protons across the membrane
HHK01_RS14035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HHK01_RS14040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHK01_RS14045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HHK01_RS14055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHK01_RS14060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHK01_RS14065	COG1301	dicarboxylic acid transport
HHK01_RS14075	COG4475	Protein of unknown function (DUF436)
HHK01_RS14080	COG0698	ribose 5-phosphate isomerase
HHK01_RS14090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHK01_RS14095	COG1971	Probably functions as a manganese efflux pump
HHK01_RS14100	COG0009	L-threonylcarbamoyladenylate synthase
HHK01_RS14110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HHK01_RS14125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HHK01_RS14130	COG1360	Flagellar Motor Protein
HHK01_RS14150	COG2890	protein-(glutamine-N5) methyltransferase activity
HHK01_RS14155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HHK01_RS14165	COG1435	thymidine kinase activity
HHK01_RS14170	COG0254	rRNA binding
HHK01_RS14175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHK01_RS14180	COG1494	fructose-1,6-bisphosphatase
HHK01_RS14185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHK01_RS14190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHK01_RS14195	COG0191	fructose-bisphosphate aldolase activity
HHK01_RS14200	COG2204	response regulator
HHK01_RS14210	COG0504	CTP synthase activity
HHK01_RS14225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHK01_RS14225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHK01_RS14225	COG1703	isobutyryl-CoA mutase activity
HHK01_RS14230	COG1309	transcriptional regulator
HHK01_RS14235	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS14240	COG1960	acyl-CoA dehydrogenase activity
HHK01_RS14245	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHK01_RS14250	COG0183	Belongs to the thiolase family
HHK01_RS14255	COG2181	nitrate reductase activity
HHK01_RS14255	COG0247	lactate metabolic process
HHK01_RS14260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHK01_RS14270	COG0018	arginyl-trna synthetase
HHK01_RS14285	COG0243	molybdopterin cofactor binding
HHK01_RS14295	COG0010	Belongs to the arginase family
HHK01_RS14300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HHK01_RS14305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHK01_RS14315	COG1227	inorganic diphosphatase activity
HHK01_RS14320	COG3465	dGTPase activity
HHK01_RS14325	COG1078	dGTPase activity
HHK01_RS14335	COG0095	Lipoate-protein ligase
HHK01_RS14340	COG0280	phosphate acetyltransferase
HHK01_RS14345	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHK01_RS14350	COG1012	belongs to the aldehyde dehydrogenase family
HHK01_RS14355	COG2610	gluconate transmembrane transporter activity
HHK01_RS14365	COG3829	transcription factor binding
HHK01_RS14365	COG3290	protein histidine kinase activity
HHK01_RS14370	COG3253	May function as heme-dependent peroxidase
HHK01_RS14375	COG3773	Cell wall hydrolase
HHK01_RS14385	COG2363	Small membrane protein
HHK01_RS14395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HHK01_RS14425	COG0745	RESPONSE REGULATOR receiver
HHK01_RS14430	COG0642	Histidine kinase
HHK01_RS14440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHK01_RS14445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHK01_RS14460	COG2188	Transcriptional regulator
HHK01_RS14475	COG0583	DNA-binding transcription factor activity
HHK01_RS14480	COG0372	Belongs to the citrate synthase family
HHK01_RS14495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHK01_RS14500	COG0561	phosphatase activity
HHK01_RS14505	COG1125	glycine betaine transport
HHK01_RS14505	COG0517	IMP dehydrogenase activity
HHK01_RS14510	COG1174	glycine betaine transport
HHK01_RS14535	COG1874	Beta-galactosidase
HHK01_RS14540	COG3833	ABC-type maltose transport systems, permease component
HHK01_RS14545	COG1175	transmembrane transport
HHK01_RS14550	COG2182	Extracellular solute-binding protein
HHK01_RS14555	COG1609	Transcriptional regulator
HHK01_RS14565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHK01_RS14570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HHK01_RS14575	COG2017	converts alpha-aldose to the beta-anomer
HHK01_RS14595	COG2814	Major facilitator Superfamily
HHK01_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS14605	COG0384	phenazine biosynthesis protein PhzF
HHK01_RS14610	COG1388	LysM domain
HHK01_RS14610	COG3858	chitin binding
HHK01_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS14625	COG1940	carbohydrate kinase activity
HHK01_RS14630	COG0673	inositol 2-dehydrogenase activity
HHK01_RS14640	COG2723	6-phospho-beta-galactosidase activity
HHK01_RS14660	COG0488	(ABC) transporter
HHK01_RS14665	COG0406	alpha-ribazole phosphatase activity
HHK01_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
HHK01_RS14675	COG0596	Alpha beta hydrolase
HHK01_RS14690	COG1070	Carbohydrate kinase
HHK01_RS14695	COG2610	gluconate transmembrane transporter activity
HHK01_RS14700	COG1737	Transcriptional regulator
HHK01_RS14715	COG1268	BioY protein
HHK01_RS14735	COG1595	DNA-templated transcription, initiation
HHK01_RS14780	COG3739	integral membrane protein
HHK01_RS14790	COG3655	Transcriptional regulator
HHK01_RS14810	COG1486	melibiose metabolic process
HHK01_RS14820	COG4191	Histidine kinase
HHK01_RS14840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHK01_RS14845	COG1309	transcriptional regulator
HHK01_RS14860	COG4533	DNA binding
HHK01_RS14870	COG1115	amino acid carrier protein
HHK01_RS14890	COG5002	protein histidine kinase activity
HHK01_RS14895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHK01_RS14905	COG0395	ABC-type sugar transport system, permease component
HHK01_RS14910	COG1175	transmembrane transport
HHK01_RS14920	COG0165	Argininosuccinate lyase
HHK01_RS14925	COG1757	Na H antiporter
HHK01_RS14935	COG3336	cytochrome c oxidase
HHK01_RS14945	COG2323	membrane
HHK01_RS14950	COG1482	cell wall glycoprotein biosynthetic process
HHK01_RS14955	COG0383	alpha-mannosidase activity
HHK01_RS14960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS14960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHK01_RS14960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHK01_RS14965	COG1737	Transcriptional regulator
HHK01_RS14970	COG2362	D-Aminopeptidase
HHK01_RS14980	COG1061	Type III restriction enzyme res subunit
HHK01_RS14985	COG0494	nUDIX hydrolase
HHK01_RS14995	COG1621	beta-fructofuranosidase activity
HHK01_RS15005	COG1070	Carbohydrate kinase
HHK01_RS15010	COG2115	Belongs to the xylose isomerase family
HHK01_RS15015	COG5578	integral membrane protein
HHK01_RS15025	COG1175	transmembrane transport
HHK01_RS15035	COG1940	carbohydrate kinase activity
HHK01_RS15040	COG3507	Belongs to the glycosyl hydrolase 43 family
HHK01_RS15045	COG1757	Na H antiporter
HHK01_RS15050	COG0579	oxidoreductase
HHK01_RS15055	COG0702	epimerase
HHK01_RS15060	COG1064	alcohol dehydrogenase
HHK01_RS15065	COG0789	Transcriptional regulator
HHK01_RS15085	COG0730	response to heat
HHK01_RS15090	COG0425	Belongs to the sulfur carrier protein TusA family
HHK01_RS15095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHK01_RS15095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHK01_RS15100	COG2210	Belongs to the sulfur carrier protein TusA family
HHK01_RS15105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHK01_RS15105	COG0425	Belongs to the sulfur carrier protein TusA family
HHK01_RS15110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHK01_RS15120	COG1937	Protein conserved in bacteria
HHK01_RS15130	COG2723	6-phospho-beta-galactosidase activity
HHK01_RS15135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHK01_RS15135	COG2190	(PTS) system
HHK01_RS15135	COG1263	PTS System
HHK01_RS15140	COG2188	Transcriptional regulator
HHK01_RS15145	COG0517	IMP dehydrogenase activity
HHK01_RS15150	COG0702	epimerase
HHK01_RS15160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHK01_RS15170	COG1309	transcriptional regulator
HHK01_RS15210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHK01_RS15215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHK01_RS15225	COG4863	YycH protein
HHK01_RS15230	COG5002	protein histidine kinase activity
HHK01_RS15235	COG0745	RESPONSE REGULATOR receiver
HHK01_RS15240	COG0739	heme binding
HHK01_RS15240	COG0741	lytic transglycosylase activity
HHK01_RS15240	COG1196	nuclear chromosome segregation
HHK01_RS15250	COG0346	lactoylglutathione lyase activity
HHK01_RS15255	COG0305	Participates in initiation and elongation during chromosome replication
HHK01_RS15270	COG1609	Transcriptional regulator
HHK01_RS15275	COG1653	transport
HHK01_RS15300	COG0673	inositol 2-dehydrogenase activity
HHK01_RS15310	COG0359	binds to the 23S rRNA
HHK01_RS15315	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HHK01_RS15325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HHK01_RS15355	COG0012	GTP binding
HHK01_RS15360	COG0582	viral genome integration into host DNA
HHK01_RS15370	COG4481	Protein conserved in bacteria
HHK01_RS15375	COG0668	transmembrane transport
HHK01_RS15385	COG1811	Na channel or pump
HHK01_RS15390	COG1475	DNA binding
HHK01_RS15395	COG1192	Involved in chromosome partitioning
HHK01_RS15400	COG1475	DNA binding
HHK01_RS15405	COG0357	Ribosomal RNA small subunit methyltransferase G
HHK01_RS15410	COG0445	tRNA wobble uridine modification
HHK01_RS15415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHK01_RS15420	COG1847	R3H domain protein
HHK01_RS15435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HHK01_RS15440	COG2340	Cysteine-rich secretory protein family
HHK01_RS15445	COG1388	LysM domain
HHK01_RS15505	COG1404	Belongs to the peptidase S8 family
HHK01_RS15635	COG0456	acetyltransferase
HHK01_RS15805	COG1404	Belongs to the peptidase S8 family