locus-tag	class	description
COP00_RS00050	COG3953	SLT domain
COP00_RS00050	COG5280	Phage tail tape measure protein TP901
COP00_RS00065	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS00090	COG5632	N-Acetylmuramoyl-L-alanine amidase
COP00_RS00090	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS00090	COG1388	LysM domain
COP00_RS00115	COG0582	viral genome integration into host DNA
COP00_RS00135	COG0456	acetyltransferase
COP00_RS00145	COG4873	Protein conserved in bacteria
COP00_RS00160	COG2244	polysaccharide biosynthetic process
COP00_RS00165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS00170	COG2217	Heavy metal translocating P-type atpase
COP00_RS00175	COG0006	proline dipeptidase activity
COP00_RS00180	COG1609	Transcriptional regulator
COP00_RS00185	COG3711	transcriptional antiterminator
COP00_RS00190	COG1263	PTS System
COP00_RS00190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS00190	COG2190	(PTS) system
COP00_RS00195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS00200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
COP00_RS00210	COG1533	DNA photolyase activity
COP00_RS00215	COG0456	acetyltransferase
COP00_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS00230	COG2084	Dehydrogenase
COP00_RS00235	COG2340	Cysteine-rich secretory protein family
COP00_RS00240	COG0768	penicillin binding
COP00_RS00245	COG4191	Histidine kinase
COP00_RS00250	COG0436	Aminotransferase
COP00_RS00265	COG0835	chemotaxis
COP00_RS00265	COG0784	Response regulator, receiver
COP00_RS00275	COG2814	Major facilitator Superfamily
COP00_RS00280	COG1376	ErfK ybiS ycfS ynhG family protein
COP00_RS00285	COG1408	metallophosphoesterase
COP00_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS00295	COG2200	EAL domain
COP00_RS00300	COG4703	Protein of unknown function (DUF1797)
COP00_RS00310	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
COP00_RS00320	COG0517	IMP dehydrogenase activity
COP00_RS00325	COG0583	DNA-binding transcription factor activity
COP00_RS00330	COG0716	FMN binding
COP00_RS00340	COG0716	FMN binding
COP00_RS00345	COG2171	N-acyltransferase activity
COP00_RS00350	COG1473	amidohydrolase
COP00_RS00360	COG0450	alkyl hydroperoxide reductase
COP00_RS00365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS00380	COG0746	molybdenum cofactor guanylyltransferase activity
COP00_RS00390	COG0303	'Molybdopterin
COP00_RS00395	COG1763	Mo-molybdopterin cofactor biosynthetic process
COP00_RS00400	COG0314	molybdopterin synthase activity
COP00_RS00405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
COP00_RS00415	COG1132	(ABC) transporter
COP00_RS00420	COG1132	(ABC) transporter
COP00_RS00430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
COP00_RS00435	COG1136	(ABC) transporter
COP00_RS00440	COG0577	efflux transmembrane transporter activity
COP00_RS00450	COG1349	DNA-binding transcription factor activity
COP00_RS00455	COG1105	Belongs to the carbohydrate kinase PfkB family
COP00_RS00460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
COP00_RS00460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
COP00_RS00460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS00480	COG0488	(ABC) transporter
COP00_RS00485	COG2309	aminopeptidase activity
COP00_RS00495	COG1077	Cell shape determining protein MreB Mrl
COP00_RS00500	COG2002	toxin-antitoxin pair type II binding
COP00_RS00505	COG3852	Histidine kinase
COP00_RS00510	COG0569	domain protein
COP00_RS00515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
COP00_RS00520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COP00_RS00525	COG5503	Protein of unknown function (DUF1447)
COP00_RS00530	COG0561	phosphatase activity
COP00_RS00535	COG0242	peptide deformylase activity
COP00_RS00545	COG0497	DNA recombination
COP00_RS00550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
COP00_RS00555	COG0022	dehydrogenase e1 component
COP00_RS00565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COP00_RS00570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS00580	COG1982	Orn Lys Arg decarboxylase major
COP00_RS00585	COG4476	Belongs to the UPF0223 family
COP00_RS00590	COG4493	Belongs to the UPF0637 family
COP00_RS00600	COG0483	inositol monophosphate 1-phosphatase activity
COP00_RS00620	COG1217	gtp-binding protein TYPA
COP00_RS00630	COG1846	Transcriptional regulator
COP00_RS00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
COP00_RS00640	COG4896	Protein conserved in bacteria
COP00_RS00650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
COP00_RS00655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
COP00_RS00660	COG2066	Belongs to the glutaminase family
COP00_RS00665	COG4838	Belongs to the UPF0358 family
COP00_RS00670	COG0772	Belongs to the SEDS family
COP00_RS00675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
COP00_RS00680	COG1612	heme a metabolic process
COP00_RS00685	COG0109	protoheme IX farnesyltransferase activity
COP00_RS00690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
COP00_RS00690	COG2010	Cytochrome c
COP00_RS00695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
COP00_RS00700	COG1845	cytochrome c oxidase, subunit III
COP00_RS00705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
COP00_RS00710	COG3336	cytochrome c oxidase
COP00_RS00720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
COP00_RS00725	COG2340	Cysteine-rich secretory protein family
COP00_RS00745	COG3679	Belongs to the UPF0342 family
COP00_RS00750	COG4471	UPF0298 protein
COP00_RS00755	COG0742	ribosomal rna small subunit methyltransferase
COP00_RS00760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COP00_RS00765	COG3314	Sporulation integral membrane protein YlbJ
COP00_RS00770	COG3480	Lon protease (S16) C-terminal proteolytic domain
COP00_RS00775	COG1323	Belongs to the UPF0348 family
COP00_RS00780	COG1399	metal-binding, possibly nucleic acid-binding protein
COP00_RS00785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
COP00_RS00795	COG0454	-acetyltransferase
COP00_RS00800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
COP00_RS00805	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
COP00_RS00810	COG2001	Belongs to the MraZ family
COP00_RS00815	COG0275	rRNA processing
COP00_RS00820	COG4839	cell division protein FtsL
COP00_RS00825	COG0768	penicillin binding
COP00_RS00830	COG0768	penicillin binding
COP00_RS00835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
COP00_RS00840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COP00_RS00845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COP00_RS00850	COG0772	Belongs to the SEDS family
COP00_RS00855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COP00_RS00860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
COP00_RS00865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
COP00_RS00870	COG3879	Bacterial protein of unknown function (DUF881)
COP00_RS00875	COG3879	Bacterial protein of unknown function (DUF881)
COP00_RS00880	COG3856	small basic protein
COP00_RS00885	COG0849	cell division
COP00_RS00890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
COP00_RS00895	COG4412	M6 family metalloprotease domain protein
COP00_RS00895	COG1404	Belongs to the peptidase S8 family
COP00_RS00900	COG4412	M6 family metalloprotease domain protein
COP00_RS00900	COG1404	Belongs to the peptidase S8 family
COP00_RS00910	COG1191	sigma factor activity
COP00_RS00915	COG1191	sigma factor activity
COP00_RS00920	COG1119	ATPase activity
COP00_RS00925	COG0500	methyltransferase
COP00_RS00930	COG1873	PFAM PRC-barrel domain
COP00_RS00935	COG1496	oxidoreductase activity
COP00_RS00940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COP00_RS00945	COG1799	cell septum assembly
COP00_RS00950	COG0762	integral membrane protein
COP00_RS00955	COG2302	S4 RNA-binding domain
COP00_RS00960	COG3599	regulation of cell shape
COP00_RS00965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COP00_RS00970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
COP00_RS00975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
COP00_RS00980	COG0564	pseudouridine synthase activity
COP00_RS00985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
COP00_RS00990	COG2233	PERMEase
COP00_RS00995	COG0540	Belongs to the ATCase OTCase family
COP00_RS01000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
COP00_RS01005	COG0505	Belongs to the CarA family
COP00_RS01010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
COP00_RS01015	COG0543	2 iron, 2 sulfur cluster binding
COP00_RS01020	COG0167	dihydroorotate dehydrogenase activity
COP00_RS01030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
COP00_RS01040	COG0175	sulfate reduction
COP00_RS01045	COG0306	phosphate transporter
COP00_RS01050	COG2046	Belongs to the sulfate adenylyltransferase family
COP00_RS01055	COG0529	Catalyzes the synthesis of activated sulfate
COP00_RS01060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
COP00_RS01065	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
COP00_RS01070	COG1648	precorrin-2 dehydrogenase activity
COP00_RS01080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
COP00_RS01085	COG1561	YicC-like family, N-terminal region
COP00_RS01090	COG2052	Domain of unknown function (DUF370)
COP00_RS01095	COG0194	GDP metabolic process
COP00_RS01100	COG1758	RNA polymerase activity
COP00_RS01105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COP00_RS01110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COP00_RS01115	COG0242	peptide deformylase activity
COP00_RS01120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COP00_RS01125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COP00_RS01125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
COP00_RS01130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
COP00_RS01135	COG0631	protein serine/threonine phosphatase activity
COP00_RS01140	COG0515	serine threonine protein kinase
COP00_RS01140	COG2815	serine threonine protein kinase
COP00_RS01145	COG1162	GTPase activity
COP00_RS01150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
COP00_RS01155	COG1564	THIamine pyrophosphokinase
COP00_RS01165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
COP00_RS01170	COG1302	Protein conserved in bacteria
COP00_RS01175	COG1461	Dihydroxyacetone kinase
COP00_RS01180	COG1760	l-serine dehydratase
COP00_RS01185	COG1760	l-serine dehydratase
COP00_RS01190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COP00_RS01195	COG1349	DNA-binding transcription factor activity
COP00_RS01200	COG0416	fatty acid biosynthetic process
COP00_RS01205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
COP00_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS01215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
COP00_RS01220	COG0571	ribonuclease III activity
COP00_RS01230	COG0552	protein localization to endoplasmic reticulum
COP00_RS01235	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
COP00_RS01240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COP00_RS01245	COG0228	four-way junction DNA binding
COP00_RS01250	COG1837	Belongs to the UPF0109 family
COP00_RS01260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COP00_RS01265	COG0336	Belongs to the RNA methyltransferase TrmD family
COP00_RS01270	COG0335	large ribosomal subunit rRNA binding
COP00_RS01275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
COP00_RS01280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COP00_RS01290	COG2257	FlhB HrpN YscU SpaS Family
COP00_RS01295	COG0045	succinate-CoA ligase (ADP-forming) activity
COP00_RS01300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
COP00_RS01305	COG0758	DNA mediated transformation
COP00_RS01310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COP00_RS01315	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
COP00_RS01320	COG4974	Belongs to the 'phage' integrase family
COP00_RS01325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
COP00_RS01330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
COP00_RS01335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
COP00_RS01340	COG1815	bacterial-type flagellum-dependent cell motility
COP00_RS01345	COG1558	bacterial-type flagellum-dependent cell motility
COP00_RS01350	COG1677	Flagellar hook-basal body complex protein FliE
COP00_RS01355	COG1766	The M ring may be actively involved in energy transduction
COP00_RS01360	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
COP00_RS01365	COG1317	bacterial-type flagellum organization
COP00_RS01370	COG1157	protein secretion by the type III secretion system
COP00_RS01375	COG2882	bacterial-type flagellum organization
COP00_RS01385	COG3144	bacterial-type flagellum assembly
COP00_RS01390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
COP00_RS01395	COG4786	Flagellar basal body rod
COP00_RS01400	COG1582	Flagellar protein (FlbD)
COP00_RS01405	COG1580	Controls the rotational direction of flagella during chemotaxis
COP00_RS01410	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
COP00_RS01415	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
COP00_RS01415	COG1776	CheC inhibitor of MCP methylation
COP00_RS01420	COG2201	protein-glutamate methylesterase activity
COP00_RS01425	COG3190	flagellar
COP00_RS01430	COG1338	Plays a role in the flagellum-specific transport system
COP00_RS01435	COG1987	bacterial-type flagellum assembly
COP00_RS01440	COG1684	flagellar biosynthetic protein fliR
COP00_RS01445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
COP00_RS01450	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
COP00_RS01455	COG1419	protein localization to endoplasmic reticulum
COP00_RS01460	COG0455	bacterial-type flagellum organization
COP00_RS01465	COG2201	protein-glutamate methylesterase activity
COP00_RS01470	COG2198	Histidine kinase
COP00_RS01470	COG0643	Histidine kinase
COP00_RS01475	COG0835	chemotaxis
COP00_RS01480	COG1776	CheC inhibitor of MCP methylation
COP00_RS01485	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
COP00_RS01490	COG1191	sigma factor activity
COP00_RS01500	COG0052	Belongs to the universal ribosomal protein uS2 family
COP00_RS01505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COP00_RS01510	COG0528	UMP kinase activity
COP00_RS01515	COG0233	cytoplasmic translational termination
COP00_RS01520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COP00_RS01525	COG4589	Belongs to the CDS family
COP00_RS01530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
COP00_RS01535	COG0750	zinc metalloprotease
COP00_RS01540	COG0442	prolyl-tRNA aminoacylation
COP00_RS01545	COG2176	DNA-directed DNA polymerase activity
COP00_RS01550	COG0457	Tetratricopeptide repeat
COP00_RS01560	COG0779	Required for maturation of 30S ribosomal subunits
COP00_RS01565	COG0195	Participates in both transcription termination and antitermination
COP00_RS01570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
COP00_RS01575	COG1358	cellular component organization or biogenesis
COP00_RS01580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COP00_RS01585	COG1550	Protein conserved in bacteria
COP00_RS01590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COP00_RS01595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
COP00_RS01600	COG0196	riboflavin kinase activity
COP00_RS01605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COP00_RS01610	COG1185	polyribonucleotide nucleotidyltransferase activity
COP00_RS01615	COG0726	polysaccharide deacetylase
COP00_RS01620	COG0612	Peptidase, M16
COP00_RS01625	COG1873	PFAM PRC-barrel domain
COP00_RS01635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COP00_RS01640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COP00_RS01645	COG0527	aspartate kinase activity
COP00_RS01655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
COP00_RS01665	COG0740	serine-type endopeptidase activity
COP00_RS01675	COG1674	ftsk spoiiie
COP00_RS01675	COG4980	gas vesicle protein
COP00_RS01680	COG2188	Transcriptional regulator
COP00_RS01685	COG2814	Major facilitator Superfamily
COP00_RS01690	COG0612	Peptidase, M16
COP00_RS01695	COG0612	Peptidase, M16
COP00_RS01700	COG0300	oxidoreductase activity
COP00_RS01715	COG1426	Protein conserved in bacteria
COP00_RS01720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COP00_RS01735	COG1418	mRNA catabolic process
COP00_RS01740	COG1692	metallophosphoesterase
COP00_RS01745	COG2359	stage V sporulation protein S
COP00_RS01755	COG1063	alcohol dehydrogenase
COP00_RS01760	COG0156	8-amino-7-oxononanoate synthase activity
COP00_RS01765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
COP00_RS01770	COG4550	Control of competence regulator ComK, YlbF/YmcA
COP00_RS01780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
COP00_RS01785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
COP00_RS01790	COG2273	Hydrolase Family 16
COP00_RS01800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS01855	COG4282	regulation of fungal-type cell wall biogenesis
COP00_RS01870	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
COP00_RS01885	COG2828	Protein conserved in bacteria
COP00_RS01890	COG3866	Pectate lyase
COP00_RS01895	COG3507	Belongs to the glycosyl hydrolase 43 family
COP00_RS01905	COG1522	sequence-specific DNA binding
COP00_RS01910	COG1902	pentaerythritol trinitrate reductase activity
COP00_RS01915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
COP00_RS01935	COG0402	S-adenosylhomocysteine deaminase activity
COP00_RS01965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COP00_RS01980	COG3619	membrane
COP00_RS01990	COG2814	Major facilitator Superfamily
COP00_RS01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COP00_RS02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COP00_RS02010	COG0393	Putative heavy-metal-binding
COP00_RS02015	COG0398	Pfam SNARE associated Golgi protein
COP00_RS02020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
COP00_RS02025	COG1819	glycosyl
COP00_RS02030	COG0531	amino acid
COP00_RS02035	COG5577	PFAM Coat F domain
COP00_RS02045	COG1388	LysM domain
COP00_RS02045	COG3858	chitin binding
COP00_RS02050	COG1309	transcriptional regulator
COP00_RS02055	COG3631	Ketosteroid isomerase-related protein
COP00_RS02060	COG0702	epimerase
COP00_RS02065	COG1764	response to oxidative stress
COP00_RS02070	COG2076	Multidrug Resistance protein
COP00_RS02075	COG2076	Multidrug Resistance protein
COP00_RS02090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COP00_RS02095	COG1923	regulation of RNA biosynthetic process
COP00_RS02105	COG1780	Probably involved in ribonucleotide reductase function
COP00_RS02110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS02115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS02120	COG4112	unkown
COP00_RS02125	COG1802	Transcriptional regulator
COP00_RS02130	COG0697	spore germination
COP00_RS02170	COG4282	regulation of fungal-type cell wall biogenesis
COP00_RS02175	COG1073	alpha beta
COP00_RS02185	COG0464	growth
COP00_RS02200	COG4282	regulation of fungal-type cell wall biogenesis
COP00_RS02205	COG5444	nuclease activity
COP00_RS02240	COG0457	Tetratricopeptide repeat
COP00_RS02260	COG5632	N-Acetylmuramoyl-L-alanine amidase
COP00_RS02265	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS02285	COG1196	nuclear chromosome segregation
COP00_RS02285	COG0741	lytic transglycosylase activity
COP00_RS02285	COG0739	heme binding
COP00_RS02290	COG0739	heme binding
COP00_RS02290	COG0741	lytic transglycosylase activity
COP00_RS02290	COG1196	nuclear chromosome segregation
COP00_RS02295	COG0739	heme binding
COP00_RS02295	COG1196	nuclear chromosome segregation
COP00_RS02295	COG0741	lytic transglycosylase activity
COP00_RS02375	COG0582	viral genome integration into host DNA
COP00_RS02470	COG4373	Mu-like prophage FluMu protein gp28
COP00_RS02510	COG0776	regulation of translation
COP00_RS02625	COG3655	Transcriptional regulator
COP00_RS02700	COG0582	viral genome integration into host DNA
COP00_RS02800	COG1793	dna ligase
COP00_RS02865	COG1404	Belongs to the peptidase S8 family
COP00_RS02910	COG3584	3D domain protein
COP00_RS02980	COG1780	Probably involved in ribonucleotide reductase function
COP00_RS02985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS02990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS02990	COG1372	Participates in initiation and elongation during chromosome replication
COP00_RS03000	COG0270	DNA (cytosine-5-)-methyltransferase activity
COP00_RS03005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS03030	COG0756	dUTP diphosphatase activity
COP00_RS03045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COP00_RS03100	COG3331	DNA recombination
COP00_RS03110	COG0464	growth
COP00_RS03115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
COP00_RS03120	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
COP00_RS03125	COG0789	Transcriptional regulator
COP00_RS03130	COG0174	glutamine synthetase
COP00_RS03135	COG4974	Belongs to the 'phage' integrase family
COP00_RS03155	COG3646	Phage regulatory protein
COP00_RS03155	COG3645	SOS response
COP00_RS03255	COG1802	Transcriptional regulator
COP00_RS03255	COG4626	Terminase
COP00_RS03270	COG0740	serine-type endopeptidase activity
COP00_RS03315	COG5280	Phage tail tape measure protein TP901
COP00_RS03315	COG3953	SLT domain
COP00_RS03325	COG1705	Flagellar rod assembly protein muramidase FlgJ
COP00_RS03330	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS03350	COG4824	toxin secretion phage lysis holin
COP00_RS03400	COG2814	Major facilitator Superfamily
COP00_RS03410	COG0490	domain, Protein
COP00_RS03415	COG0475	glutathione-regulated potassium exporter activity
COP00_RS03440	COG0756	dUTP diphosphatase activity
COP00_RS03450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
COP00_RS03475	COG1231	oxidoreductase activity
COP00_RS03485	COG1309	transcriptional regulator
COP00_RS03490	COG2076	Multidrug Resistance protein
COP00_RS03495	COG2076	Multidrug Resistance protein
COP00_RS03500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS03565	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS03575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COP00_RS03580	COG1388	LysM domain
COP00_RS03585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
COP00_RS03590	COG4224	UPF0291 protein
COP00_RS03595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
COP00_RS03605	COG3763	UPF0154 protein
COP00_RS03615	COG0785	Cytochrome C biogenesis protein
COP00_RS03620	COG2201	protein-glutamate methylesterase activity
COP00_RS03625	COG4846	Membrane protein involved in cytochrome C biogenesis
COP00_RS03635	COG0071	Belongs to the small heat shock protein (HSP20) family
COP00_RS03650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
COP00_RS03655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS03675	COG0824	Thioesterase
COP00_RS03685	COG4841	protein insertion into membrane
COP00_RS03690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
COP00_RS03695	COG1832	CoA-binding protein
COP00_RS03700	COG0187	DNA topoisomerase II activity
COP00_RS03705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COP00_RS03710	COG1609	Transcriptional regulator
COP00_RS03725	COG2160	L-arabinose isomerase activity
COP00_RS03755	COG2181	nitrate reductase activity
COP00_RS03760	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
COP00_RS03765	COG1140	nitrate reductase beta subunit
COP00_RS03770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
COP00_RS03785	COG0535	radical SAM domain protein
COP00_RS03790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
COP00_RS03800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
COP00_RS03805	COG2223	nitrite transmembrane transporter activity
COP00_RS03830	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
COP00_RS03840	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
COP00_RS03850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS03870	COG0574	Belongs to the PEP-utilizing enzyme family
COP00_RS03870	COG3848	Pyruvate phosphate dikinase
COP00_RS03880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COP00_RS03885	COG0798	PFAM Bile acid sodium symporter
COP00_RS03890	COG0640	Transcriptional regulator
COP00_RS03895	COG0693	protein deglycase activity
COP00_RS03925	COG1687	branched-chain amino acid
COP00_RS03930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
COP00_RS03935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS03955	COG1024	Enoyl-CoA hydratase
COP00_RS03960	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS03965	COG2084	Dehydrogenase
COP00_RS03970	COG1960	acyl-CoA dehydrogenase activity
COP00_RS03980	COG0789	Transcriptional regulator
COP00_RS03995	COG1064	alcohol dehydrogenase
COP00_RS04000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
COP00_RS04010	COG1388	LysM domain
COP00_RS04015	COG2205	protein histidine kinase activity
COP00_RS04050	COG1482	cell wall glycoprotein biosynthetic process
COP00_RS04060	COG3711	transcriptional antiterminator
COP00_RS04060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS04065	COG0785	Cytochrome C biogenesis protein
COP00_RS04070	COG2814	Major facilitator Superfamily
COP00_RS04095	COG1131	(ABC) transporter
COP00_RS04100	COG1725	Transcriptional regulator
COP00_RS04115	COG1309	transcriptional regulator
COP00_RS04135	COG1649	PFAM Uncharacterised BCR, COG1649
COP00_RS04145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
COP00_RS04150	COG1882	Formate acetyltransferase
COP00_RS04170	COG2027	D-alanyl-D-alanine carboxypeptidase
COP00_RS04175	COG1252	NADH dehydrogenase
COP00_RS04190	COG0166	Belongs to the GPI family
COP00_RS04200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
COP00_RS04205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
COP00_RS04210	COG1024	Enoyl-CoA hydratase
COP00_RS04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
COP00_RS04220	COG0511	ligase activity, forming carbon-carbon bonds
COP00_RS04225	COG0439	Biotin carboxylase
COP00_RS04230	COG0318	PFAM AMP-dependent synthetase and ligase
COP00_RS04235	COG1960	acyl-CoA dehydrogenase activity
COP00_RS04245	COG1733	regulation of RNA biosynthetic process
COP00_RS04280	COG2323	membrane
COP00_RS04290	COG0175	sulfate reduction
COP00_RS04295	COG1809	phosphosulfolactate synthase activity
COP00_RS04300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS04305	COG4948	Mandelate Racemase Muconate Lactonizing
COP00_RS04310	COG2814	Major facilitator Superfamily
COP00_RS04315	COG0463	Glycosyl transferase, family 2
COP00_RS04330	COG0493	'glutamate synthase
COP00_RS04335	COG0069	glutamate synthase activity
COP00_RS04335	COG0067	glutamate synthase
COP00_RS04335	COG0070	glutamate synthase
COP00_RS04365	COG1132	(ABC) transporter
COP00_RS04370	COG3540	Alkaline phosphatase
COP00_RS04380	COG0300	oxidoreductase activity
COP00_RS04385	COG0477	Major facilitator Superfamily
COP00_RS04390	COG0243	molybdopterin cofactor binding
COP00_RS04395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
COP00_RS04400	COG1846	Transcriptional regulator
COP00_RS04405	COG2814	Major facilitator Superfamily
COP00_RS04410	COG0531	amino acid
COP00_RS04420	COG0531	amino acid
COP00_RS04425	COG0531	amino acid
COP00_RS04430	COG0697	spore germination
COP00_RS04440	COG0488	(ABC) transporter
COP00_RS04460	COG0840	transmembrane signaling receptor activity
COP00_RS04465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COP00_RS04470	COG1404	Belongs to the peptidase S8 family
COP00_RS04480	COG1309	transcriptional regulator
COP00_RS04490	COG1309	transcriptional regulator
COP00_RS04495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS04500	COG3708	Transcriptional regulator
COP00_RS04515	COG2378	regulation of single-species biofilm formation
COP00_RS04525	COG0640	Transcriptional regulator
COP00_RS04535	COG0531	amino acid
COP00_RS04540	COG0741	lytic transglycosylase activity
COP00_RS04545	COG1086	Polysaccharide biosynthesis protein
COP00_RS04565	COG2322	membrane
COP00_RS04575	COG1619	proteins homologs of microcin C7 resistance protein MccF
COP00_RS04580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS04585	COG1388	LysM domain
COP00_RS04595	COG3584	3D domain protein
COP00_RS04595	COG1388	LysM domain
COP00_RS04600	COG0514	ATP-dependent DNA helicase (RecQ)
COP00_RS04680	COG0702	epimerase
COP00_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS04705	COG1357	PFAM Pentapeptide repeats (8 copies)
COP00_RS04720	COG1280	lysine exporter protein (LysE YggA)
COP00_RS04725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COP00_RS04785	COG2318	DinB family
COP00_RS04790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
COP00_RS04795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
COP00_RS04800	COG2140	Oxalate decarboxylase
COP00_RS04815	COG0288	reversible hydration of carbon dioxide
COP00_RS04820	COG3002	Belongs to the UPF0753 family
COP00_RS04825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
COP00_RS04830	COG5609	conserved protein (DUF2294)
COP00_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS04870	COG0667	Aldo Keto reductase
COP00_RS04875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COP00_RS04880	COG1846	Transcriptional regulator
COP00_RS04885	COG1657	PFAM Prenyltransferase squalene oxidase
COP00_RS04890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
COP00_RS04895	COG0733	neurotransmitter:sodium symporter activity
COP00_RS04900	COG0385	Bile acid
COP00_RS04905	COG0508	dehydrogenase complex catalyzes the overall conversion of
COP00_RS04910	COG0567	Dehydrogenase, E1 component
COP00_RS04915	COG4548	von Willebrand factor, type A
COP00_RS04920	COG0714	Associated with various cellular activities
COP00_RS04925	COG2032	superoxide dismutase activity
COP00_RS04930	COG1388	LysM domain
COP00_RS04930	COG0791	NLP P60 protein
COP00_RS04935	COG0534	Mate efflux family protein
COP00_RS04940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
COP00_RS04945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
COP00_RS04955	COG2962	Rard protein
COP00_RS04965	COG4305	rare lipoprotein A
COP00_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS04980	COG1733	regulation of RNA biosynthetic process
COP00_RS04985	COG0778	Nitroreductase
COP00_RS04990	COG0400	carboxylic ester hydrolase activity
COP00_RS04995	COG0346	lactoylglutathione lyase activity
COP00_RS05005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COP00_RS05010	COG0793	Belongs to the peptidase S41A family
COP00_RS05010	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS05015	COG2226	methyltransferase
COP00_RS05025	COG1876	peptidase activity
COP00_RS05030	COG0813	purine-nucleoside phosphorylase activity
COP00_RS05035	COG0701	Predicted permease
COP00_RS05055	COG0671	phosphoesterase, PA-phosphatase related
COP00_RS05075	COG4479	Belongs to the UPF0346 family
COP00_RS05085	COG1509	lysine 2,3-aminomutase activity
COP00_RS05090	COG0456	acetyltransferase
COP00_RS05095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
COP00_RS05100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
COP00_RS05105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
COP00_RS05110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
COP00_RS05125	COG0456	acetyltransferase
COP00_RS05130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COP00_RS05135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COP00_RS05140	COG1846	Transcriptional regulator
COP00_RS05150	COG0534	Mate efflux family protein
COP00_RS05165	COG4698	Protein conserved in bacteria
COP00_RS05175	COG1999	signal sequence binding
COP00_RS05190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
COP00_RS05195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
COP00_RS05200	COG1272	protein, Hemolysin III
COP00_RS05205	COG0204	Acyl-transferase
COP00_RS05210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
COP00_RS05215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
COP00_RS05230	COG2136	Putative SAM-dependent methyltransferase
COP00_RS05230	COG2521	methyltransferase
COP00_RS05240	COG0129	dihydroxy-acid dehydratase activity
COP00_RS05245	COG1413	lyase activity
COP00_RS05250	COG1418	mRNA catabolic process
COP00_RS05255	COG0386	Belongs to the glutathione peroxidase family
COP00_RS05260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
COP00_RS05265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
COP00_RS05270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COP00_RS05280	COG1278	Cold shock
COP00_RS05300	COG0328	RNA-DNA hybrid ribonuclease activity
COP00_RS05305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
COP00_RS05310	COG0328	RNA-DNA hybrid ribonuclease activity
COP00_RS05320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS05345	COG1755	Isoprenylcysteine carboxyl methyltransferase
COP00_RS05350	COG3424	synthase
COP00_RS05360	COG2233	PERMEase
COP00_RS05365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COP00_RS05370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
COP00_RS05375	COG1199	ATP-dependent helicase activity
COP00_RS05390	COG0116	Belongs to the methyltransferase superfamily
COP00_RS05400	COG3599	regulation of cell shape
COP00_RS05405	COG4474	Belongs to the UPF0398 family
COP00_RS05415	COG3359	exonuclease
COP00_RS05420	COG1205	dead DEAH box helicase
COP00_RS05420	COG1111	helicase
COP00_RS05425	COG2190	(PTS) system
COP00_RS05430	COG0071	Belongs to the small heat shock protein (HSP20) family
COP00_RS05465	COG3331	DNA recombination
COP00_RS05470	COG4499	WXG100 protein secretion system (Wss), protein YukC
COP00_RS05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
COP00_RS05480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COP00_RS05485	COG3935	DnaD domain protein
COP00_RS05490	COG0017	Asparaginyl-tRNA synthetase
COP00_RS05495	COG0436	Aminotransferase
COP00_RS05500	COG5353	protein conserved in bacteria
COP00_RS05510	COG1199	ATP-dependent helicase activity
COP00_RS05510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
COP00_RS05515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
COP00_RS05520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
COP00_RS05525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
COP00_RS05535	COG0617	tRNA 3'-terminal CCA addition
COP00_RS05540	COG0438	transferase activity, transferring glycosyl groups
COP00_RS05545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
COP00_RS05550	COG1803	Methylglyoxal synthase
COP00_RS05555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
COP00_RS05560	COG1694	Mazg nucleotide pyrophosphohydrolase
COP00_RS05565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS05575	COG4347	Protein of unknown function (DUF1405)
COP00_RS05580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
COP00_RS05580	COG2010	Cytochrome c
COP00_RS05585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
COP00_RS05590	COG0723	plastoquinol--plastocyanin reductase activity
COP00_RS05600	COG5582	Belongs to the UPF0302 family
COP00_RS05605	COG0457	Tetratricopeptide repeat
COP00_RS05610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
COP00_RS05615	COG0287	Prephenate dehydrogenase
COP00_RS05620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COP00_RS05625	COG0159	tryptophan synthase activity
COP00_RS05630	COG0133	tryptophan synthase activity
COP00_RS05635	COG0135	phosphoribosylanthranilate isomerase activity
COP00_RS05640	COG0134	indole-3-glycerol-phosphate synthase activity
COP00_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COP00_RS05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COP00_RS05655	COG4401	Chorismate mutase type I
COP00_RS05660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
COP00_RS05665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COP00_RS05670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
COP00_RS05675	COG0105	UTP biosynthetic process
COP00_RS05680	COG0142	geranyltranstransferase activity
COP00_RS05685	COG2226	methyltransferase
COP00_RS05690	COG0142	geranyltranstransferase activity
COP00_RS05705	COG0776	regulation of translation
COP00_RS05710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
COP00_RS05730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
COP00_RS05735	COG1160	GTP binding
COP00_RS05760	COG1304	FMN binding
COP00_RS05765	COG0539	negative regulation of cytoplasmic translation
COP00_RS05770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
COP00_RS05780	COG2959	enzyme of heme biosynthesis
COP00_RS05785	COG3773	Cell wall hydrolase
COP00_RS05785	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS05790	COG2339	peptidase activity
COP00_RS05800	COG0492	ferredoxin-NADP+ reductase activity
COP00_RS05805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
COP00_RS05810	COG4862	establishment of competence for transformation
COP00_RS05815	COG1408	metallophosphoesterase
COP00_RS05825	COG1388	LysM domain
COP00_RS05830	COG1266	CAAX protease self-immunity
COP00_RS05835	COG0514	ATP-dependent DNA helicase (RecQ)
COP00_RS05840	COG4955	Helix-turn-helix domain
COP00_RS05845	COG1141	Ferredoxin
COP00_RS05850	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
COP00_RS05855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
COP00_RS05860	COG0739	heme binding
COP00_RS05870	COG1595	DNA-templated transcription, initiation
COP00_RS05875	COG1316	TRANSCRIPTIONal
COP00_RS05890	COG5002	protein histidine kinase activity
COP00_RS05895	COG0745	RESPONSE REGULATOR receiver
COP00_RS05910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
COP00_RS05915	COG1333	cytochrome c biogenesis protein
COP00_RS05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS05925	COG1187	pseudouridine synthase activity
COP00_RS05930	COG0700	Nucleoside recognition
COP00_RS05935	COG2715	membrane protein required for spore maturation
COP00_RS05940	COG1686	Belongs to the peptidase S11 family
COP00_RS05960	COG1547	Domain of unknown function (DUF309)
COP00_RS05965	COG0456	acetyltransferase
COP00_RS05975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
COP00_RS05975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
COP00_RS05980	COG0307	riboflavin synthase, alpha
COP00_RS05985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COP00_RS05985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COP00_RS06005	COG0457	Tetratricopeptide repeat
COP00_RS06010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COP00_RS06015	COG4086	secreted protein
COP00_RS06020	COG4195	phage-related replication protein
COP00_RS06030	COG0019	diaminopimelate decarboxylase activity
COP00_RS06040	COG0697	spore germination
COP00_RS06055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COP00_RS06090	COG1686	Belongs to the peptidase S11 family
COP00_RS06095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
COP00_RS06100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
COP00_RS06105	COG4974	Belongs to the 'phage' integrase family
COP00_RS06115	COG0735	belongs to the Fur family
COP00_RS06120	COG1300	Membrane
COP00_RS06125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS06145	COG2153	protein acetylation
COP00_RS06150	COG1379	DNA repair
COP00_RS06155	COG0494	nUDIX hydrolase
COP00_RS06165	COG1309	transcriptional regulator
COP00_RS06175	COG0667	Aldo Keto reductase
COP00_RS06180	COG0477	Major facilitator Superfamily
COP00_RS06185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS06190	COG3420	alginic acid biosynthetic process
COP00_RS06210	COG1073	alpha beta
COP00_RS06220	COG4918	Iron-sulphur cluster biosynthesis
COP00_RS06230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COP00_RS06230	COG0456	acetyltransferase
COP00_RS06240	COG0456	acetyltransferase
COP00_RS06250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
COP00_RS06275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COP00_RS06290	COG2211	Major facilitator Superfamily
COP00_RS06295	COG0346	lactoylglutathione lyase activity
COP00_RS06300	COG1072	(Pantothenic acid kinase))
COP00_RS06310	COG1131	(ABC) transporter
COP00_RS06340	COG4195	phage-related replication protein
COP00_RS06345	COG0300	oxidoreductase activity
COP00_RS06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS06355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COP00_RS06360	COG4187	Peptidase family M20/M25/M40
COP00_RS06365	COG1902	pentaerythritol trinitrate reductase activity
COP00_RS06370	COG0596	Alpha beta hydrolase
COP00_RS06375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
COP00_RS06380	COG1234	tRNA 3'-trailer cleavage
COP00_RS06385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
COP00_RS06390	COG2188	Transcriptional regulator
COP00_RS06395	COG2723	6-phospho-beta-galactosidase activity
COP00_RS06400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS06405	COG1447	Phosphotransferase system cellobiose-specific component IIA
COP00_RS06410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS06415	COG1785	Belongs to the alkaline phosphatase family
COP00_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS06425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
COP00_RS06430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COP00_RS06440	COG0706	membrane insertase activity
COP00_RS06450	COG2195	Cleaves the N-terminal amino acid of tripeptides
COP00_RS06455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
COP00_RS06460	COG4129	membrane
COP00_RS06465	COG1126	abc transporter atp-binding protein
COP00_RS06470	COG0765	amino acid transport
COP00_RS06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COP00_RS06485	COG1597	lipid kinase activity
COP00_RS06490	COG0508	dehydrogenase complex catalyzes the overall conversion of
COP00_RS06495	COG0022	dehydrogenase e1 component
COP00_RS06500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
COP00_RS06505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COP00_RS06510	COG3426	butyrate kinase activity
COP00_RS06520	COG0280	phosphate acetyltransferase
COP00_RS06525	COG3829	transcription factor binding
COP00_RS06525	COG3290	protein histidine kinase activity
COP00_RS06535	COG0584	glycerophosphoryl diester phosphodiesterase
COP00_RS06540	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
COP00_RS06555	COG0745	RESPONSE REGULATOR receiver
COP00_RS06560	COG0750	zinc metalloprotease
COP00_RS06565	COG0497	DNA recombination
COP00_RS06570	COG1438	arginine binding
COP00_RS06575	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
COP00_RS06580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
COP00_RS06585	COG0142	geranyltranstransferase activity
COP00_RS06590	COG1722	exodeoxyribonuclease VII activity
COP00_RS06595	COG1570	exodeoxyribonuclease VII activity
COP00_RS06600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COP00_RS06605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COP00_RS06610	COG1302	Protein conserved in bacteria
COP00_RS06615	COG0439	Biotin carboxylase
COP00_RS06620	COG0511	ligase activity, forming carbon-carbon bonds
COP00_RS06660	COG3854	ATPases associated with a variety of cellular activities
COP00_RS06675	COG0006	proline dipeptidase activity
COP00_RS06680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
COP00_RS06690	COG3872	metal-dependent enzyme
COP00_RS06700	COG1752	Esterase of the alpha-beta hydrolase superfamily
COP00_RS06705	COG1321	iron dependent repressor
COP00_RS06715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COP00_RS06720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
COP00_RS06725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
COP00_RS06730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
COP00_RS06735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COP00_RS06760	COG0681	Belongs to the peptidase S26 family
COP00_RS06785	COG4940	Competence protein ComGF
COP00_RS06795	COG4970	Tfp pilus assembly protein FimT
COP00_RS06800	COG4537	Required for transformation and DNA binding
COP00_RS06805	COG1459	type II secretion system
COP00_RS06810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
COP00_RS06815	COG1366	Belongs to the anti-sigma-factor antagonist family
COP00_RS06825	COG1393	Belongs to the ArsC family
COP00_RS06835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS06845	COG0011	TIGRFAM Protein of
COP00_RS06855	COG2866	Carboxypeptidase
COP00_RS06930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS06940	COG2116	formate transmembrane transporter activity
COP00_RS06955	COG1368	sulfuric ester hydrolase activity
COP00_RS06960	COG1940	carbohydrate kinase activity
COP00_RS06965	COG4483	Protein conserved in bacteria
COP00_RS06970	COG0697	spore germination
COP00_RS06975	COG0705	Rhomboid family
COP00_RS06975	COG0457	Tetratricopeptide repeat
COP00_RS06985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COP00_RS07010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
COP00_RS07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
COP00_RS07020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
COP00_RS07025	COG0581	inorganic phosphate transmembrane transporter activity
COP00_RS07030	COG0573	inorganic phosphate transmembrane transporter activity
COP00_RS07035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
COP00_RS07040	COG0768	penicillin binding
COP00_RS07045	COG0477	Major facilitator Superfamily
COP00_RS07050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
COP00_RS07055	COG2839	Protein conserved in bacteria
COP00_RS07060	COG5521	maltodextrose utilization protein MalA
COP00_RS07065	COG1388	LysM domain
COP00_RS07070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
COP00_RS07075	COG4709	membrane
COP00_RS07080	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
COP00_RS07085	COG0735	belongs to the Fur family
COP00_RS07090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
COP00_RS07095	COG1121	(ABC) transporter
COP00_RS07100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS07110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
COP00_RS07125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
COP00_RS07130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COP00_RS07135	COG2384	SAM-dependent methyltransferase
COP00_RS07170	COG2010	Cytochrome c
COP00_RS07175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
COP00_RS07180	COG0358	DNA primase activity
COP00_RS07185	COG1671	Belongs to the UPF0178 family
COP00_RS07190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
COP00_RS07195	COG0517	IMP dehydrogenase activity
COP00_RS07200	COG0751	glycine-tRNA ligase activity
COP00_RS07205	COG0752	glycyl-tRNA synthetase alpha subunit
COP00_RS07210	COG1381	Involved in DNA repair and RecF pathway recombination
COP00_RS07220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
COP00_RS07230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
COP00_RS07235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COP00_RS07240	COG1480	7TM receptor with intracellular HD hydrolase
COP00_RS07245	COG1702	phosphate starvation-inducible protein PhoH
COP00_RS07250	COG0561	phosphatase activity
COP00_RS07265	COG4864	UPF0365 protein
COP00_RS07270	COG1030	water channel activity
COP00_RS07275	COG1610	YqeY-like protein
COP00_RS07280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
COP00_RS07285	COG1283	sodium-dependent phosphate transmembrane transporter activity
COP00_RS07290	COG1247	-acetyltransferase
COP00_RS07295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
COP00_RS07300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
COP00_RS07305	COG2264	protein methyltransferase activity
COP00_RS07310	COG0484	heat shock protein binding
COP00_RS07315	COG0443	Heat shock 70 kDa protein
COP00_RS07320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COP00_RS07325	COG1420	regulation of RNA biosynthetic process
COP00_RS07330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
COP00_RS07335	COG0481	GTPase activity
COP00_RS07345	COG0860	N-Acetylmuramoyl-L-alanine amidase
COP00_RS07350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
COP00_RS07355	COG0268	Binds directly to 16S ribosomal RNA
COP00_RS07360	COG1466	dna polymerase III delta subunit
COP00_RS07370	COG2333	competence protein COMEC
COP00_RS07370	COG0658	competence protein
COP00_RS07375	COG2131	deaminase
COP00_RS07380	COG1596	polysaccharide export
COP00_RS07380	COG1555	photosystem II stabilization
COP00_RS07385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COP00_RS07390	COG2226	methyltransferase
COP00_RS07395	COG0799	negative regulation of ribosome biogenesis
COP00_RS07400	COG1713	HD superfamily hydrolase involved in NAD metabolism
COP00_RS07405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COP00_RS07410	COG1534	Rna-binding protein
COP00_RS07415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COP00_RS07420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
COP00_RS07425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
COP00_RS07435	COG2755	lipolytic protein G-D-S-L family
COP00_RS07445	COG5609	conserved protein (DUF2294)
COP00_RS07450	COG3383	formate dehydrogenase (NAD+) activity
COP00_RS07480	COG0583	DNA-binding transcription factor activity
COP00_RS07485	COG2070	2-Nitropropane dioxygenase
COP00_RS07495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
COP00_RS07500	COG0604	alcohol dehydrogenase
COP00_RS07520	COG0789	Transcriptional regulator
COP00_RS07520	COG4978	Transcriptional regulator
COP00_RS07560	COG0071	Belongs to the small heat shock protein (HSP20) family
COP00_RS07565	COG2409	Drug exporters of the RND superfamily
COP00_RS07570	COG2197	response regulator
COP00_RS07575	COG4585	Histidine kinase
COP00_RS07595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
COP00_RS07620	COG2197	response regulator
COP00_RS07625	COG4585	Histidine kinase
COP00_RS07630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS07635	COG0730	response to heat
COP00_RS07645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COP00_RS07645	COG0425	Belongs to the sulfur carrier protein TusA family
COP00_RS07650	COG2210	Belongs to the sulfur carrier protein TusA family
COP00_RS07655	COG1937	Protein conserved in bacteria
COP00_RS07680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
COP00_RS07685	COG1522	sequence-specific DNA binding
COP00_RS07705	COG1486	melibiose metabolic process
COP00_RS07710	COG0561	phosphatase activity
COP00_RS07730	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS07740	COG0492	ferredoxin-NADP+ reductase activity
COP00_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS07760	COG1942	4-Oxalocrotonate Tautomerase
COP00_RS07775	COG3443	Belongs to the bacterial solute-binding protein 9 family
COP00_RS07780	COG2124	cytochrome p450
COP00_RS07785	COG2368	4-hydroxyphenylacetate
COP00_RS07795	COG0833	amino acid
COP00_RS07800	COG4187	Peptidase family M20/M25/M40
COP00_RS07810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
COP00_RS07820	COG5583	Uncharacterized small protein (DUF2292)
COP00_RS07850	COG1621	beta-fructofuranosidase activity
COP00_RS07855	COG3716	PTS system mannose fructose sorbose family IID component
COP00_RS07860	COG3715	PTS system
COP00_RS07865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS07870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS07875	COG3933	PFAM sigma-54 factor interaction domain-containing protein
COP00_RS07875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
COP00_RS07890	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
COP00_RS07905	COG1113	amino acid transport
COP00_RS07915	COG0583	DNA-binding transcription factor activity
COP00_RS07920	COG1525	nuclease
COP00_RS07935	COG2814	Major facilitator Superfamily
COP00_RS07945	COG2350	Protein conserved in bacteria
COP00_RS07955	COG2169	Transcriptional regulator
COP00_RS07960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
COP00_RS07975	COG1733	regulation of RNA biosynthetic process
COP00_RS07980	COG1587	Uroporphyrinogen-III synthase
COP00_RS07990	COG0583	DNA-binding transcription factor activity
COP00_RS08005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
COP00_RS08005	COG2124	cytochrome p450
COP00_RS08010	COG1309	transcriptional regulator
COP00_RS08020	COG1404	Belongs to the peptidase S8 family
COP00_RS08050	COG0626	cystathionine gamma-synthase activity
COP00_RS08055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
COP00_RS08060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COP00_RS08065	COG2226	methyltransferase
COP00_RS08080	COG0768	penicillin binding
COP00_RS08085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COP00_RS08090	COG0572	uridine kinase
COP00_RS08095	COG0826	peptidase U32
COP00_RS08100	COG0826	peptidase U32
COP00_RS08105	COG4122	O-methyltransferase activity
COP00_RS08110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
COP00_RS08115	COG3906	Belongs to the UPF0473 family
COP00_RS08120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COP00_RS08125	COG4472	Bacterial protein of unknown function (DUF965)
COP00_RS08130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COP00_RS08135	COG0628	permease
COP00_RS08140	COG1126	abc transporter atp-binding protein
COP00_RS08145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COP00_RS08150	COG0765	amino acid transport
COP00_RS08155	COG0765	amino acid transport
COP00_RS08170	COG3881	PFAM PRC-barrel domain
COP00_RS08175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
COP00_RS08180	COG0457	Tetratricopeptide repeat
COP00_RS08185	COG0482	sulfurtransferase activity
COP00_RS08190	COG1104	cysteine desulfurase activity
COP00_RS08195	COG1959	2 iron, 2 sulfur cluster binding
COP00_RS08200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
COP00_RS08210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
COP00_RS08220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
COP00_RS08225	COG0124	histidyl-tRNA synthetase
COP00_RS08235	COG3103	Sh3 type 3 domain protein
COP00_RS08235	COG0860	N-Acetylmuramoyl-L-alanine amidase
COP00_RS08235	COG4991	sh3 domain protein
COP00_RS08240	COG1490	D-aminoacyl-tRNA deacylase activity
COP00_RS08245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COP00_RS08250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COP00_RS08255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
COP00_RS08255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
COP00_RS08260	COG5416	Lipopolysaccharide assembly protein A domain
COP00_RS08265	COG0490	domain, Protein
COP00_RS08270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COP00_RS08270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COP00_RS08280	COG2244	polysaccharide biosynthetic process
COP00_RS08285	COG2323	membrane
COP00_RS08295	COG1862	Preprotein translocase
COP00_RS08300	COG0343	queuine tRNA-ribosyltransferase activity
COP00_RS08305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
COP00_RS08315	COG2255	four-way junction helicase activity
COP00_RS08320	COG0632	four-way junction helicase activity
COP00_RS08330	COG2112	serine threonine protein kinase
COP00_RS08340	COG2318	DinB family
COP00_RS08345	COG4195	phage-related replication protein
COP00_RS08360	COG0217	transcriptional regulatory protein
COP00_RS08370	COG1388	LysM domain
COP00_RS08380	COG0157	Belongs to the NadC ModD family
COP00_RS08385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
COP00_RS08395	COG1827	regulation of RNA biosynthetic process
COP00_RS08400	COG0077	Prephenate dehydratase
COP00_RS08405	COG4492	Belongs to the UPF0735 family
COP00_RS08410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COP00_RS08415	COG3290	protein histidine kinase activity
COP00_RS08420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
COP00_RS08425	COG2868	ribosomal protein
COP00_RS08430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
COP00_RS08435	COG1994	Peptidase M50
COP00_RS08440	COG0739	heme binding
COP00_RS08445	COG3832	glyoxalase III activity
COP00_RS08450	COG0640	Transcriptional regulator
COP00_RS08455	COG2894	cell division
COP00_RS08460	COG0850	regulation of cytokinetic process
COP00_RS08465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
COP00_RS08475	COG1077	Cell shape determining protein MreB Mrl
COP00_RS08480	COG2003	Belongs to the UPF0758 family
COP00_RS08485	COG0424	maF-like protein
COP00_RS08495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
COP00_RS08500	COG0285	dihydrofolate synthase activity
COP00_RS08515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
COP00_RS08520	COG1388	LysM domain
COP00_RS08525	COG1388	LysM domain
COP00_RS08530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
COP00_RS08535	COG0113	porphobilinogen synthase activity
COP00_RS08540	COG1587	Uroporphyrinogen-III synthase
COP00_RS08545	COG0181	hydroxymethylbilane synthase activity
COP00_RS08550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
COP00_RS08555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
COP00_RS08565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
COP00_RS08570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
COP00_RS08575	COG1067	ATP-dependent peptidase activity
COP00_RS08575	COG0470	DNA polymerase III
COP00_RS08580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COP00_RS08585	COG0544	peptidyl-prolyl cis-trans isomerase activity
COP00_RS08595	COG0066	3-isopropylmalate dehydratase activity
COP00_RS08605	COG0473	3-isopropylmalate dehydrogenase activity
COP00_RS08610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
COP00_RS08615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
COP00_RS08620	COG0440	acetolactate synthase activity
COP00_RS08625	COG0028	Belongs to the TPP enzyme family
COP00_RS08630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
COP00_RS08640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
COP00_RS08680	COG0622	Phosphoesterase
COP00_RS08685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COP00_RS08690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
COP00_RS08695	COG5401	PFAM Sporulation and spore germination
COP00_RS08700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
COP00_RS08705	COG1846	Transcriptional regulator
COP00_RS08710	COG2197	response regulator
COP00_RS08715	COG4221	oxidoreductase activity
COP00_RS08720	COG0824	Thioesterase
COP00_RS08725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
COP00_RS08730	COG1053	succinate dehydrogenase
COP00_RS08735	COG2009	succinate dehydrogenase
COP00_RS08740	COG1719	4-vinyl reductase, 4VR
COP00_RS08750	COG0527	aspartate kinase activity
COP00_RS08760	COG0322	excinuclease ABC activity
COP00_RS08765	COG3118	belongs to the thioredoxin family
COP00_RS08770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
COP00_RS08775	COG2086	electron transfer activity
COP00_RS08780	COG1024	Enoyl-CoA hydratase
COP00_RS08785	COG1309	transcriptional regulator
COP00_RS08800	COG2249	NAD(P)H dehydrogenase (quinone) activity
COP00_RS08815	COG3766	membrane
COP00_RS08820	COG1193	negative regulation of DNA recombination
COP00_RS08825	COG1796	DNA polymerase
COP00_RS08825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
COP00_RS08830	COG1286	toxin biosynthetic process
COP00_RS08835	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
COP00_RS08840	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
COP00_RS08855	COG0072	phenylalanine-tRNA ligase activity
COP00_RS08855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COP00_RS08860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COP00_RS08865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COP00_RS08875	COG1966	Carbon starvation protein
COP00_RS08880	COG1309	transcriptional regulator
COP00_RS08885	COG3402	PFAM membrane-flanked domain
COP00_RS08890	COG3428	Bacterial PH domain
COP00_RS08905	COG0395	ABC-type sugar transport system, permease component
COP00_RS08910	COG1175	transmembrane transport
COP00_RS08915	COG1653	transport
COP00_RS08920	COG0371	Dehydrogenase
COP00_RS08925	COG0235	Class ii aldolase
COP00_RS08930	COG1069	ribulokinase activity
COP00_RS08935	COG2160	L-arabinose isomerase activity
COP00_RS08945	COG1363	Peptidase, m42
COP00_RS08955	COG3326	Membrane
COP00_RS08960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COP00_RS08970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
COP00_RS08975	COG1346	cytolysis
COP00_RS08980	COG1380	Effector of murein hydrolase LrgA
COP00_RS08985	COG3540	Alkaline phosphatase
COP00_RS08990	COG3279	Response regulator of the LytR AlgR family
COP00_RS08995	COG3275	phosphorelay sensor kinase activity
COP00_RS09000	COG1011	Hydrolase
COP00_RS09015	COG0398	Pfam SNARE associated Golgi protein
COP00_RS09020	COG1484	DNA-dependent DNA replication
COP00_RS09025	COG3611	Membrane attachment protein
COP00_RS09030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
COP00_RS09040	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
COP00_RS09045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
COP00_RS09050	COG3866	Pectate lyase
COP00_RS09055	COG0237	dephospho-CoA kinase activity
COP00_RS09060	COG1971	Probably functions as a manganese efflux pump
COP00_RS09065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
COP00_RS09070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS09070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS09075	COG5002	protein histidine kinase activity
COP00_RS09080	COG0745	RESPONSE REGULATOR receiver
COP00_RS09085	COG0039	L-malate dehydrogenase activity
COP00_RS09090	COG0538	isocitrate dehydrogenase activity
COP00_RS09095	COG0372	Belongs to the citrate synthase family
COP00_RS09100	COG2707	UPF0756 membrane protein
COP00_RS09105	COG0628	permease
COP00_RS09110	COG3030	protein affecting phage T7 exclusion by the F plasmid
COP00_RS09120	COG0205	6-phosphofructokinase activity
COP00_RS09125	COG0825	malonyl-CoA metabolic process
COP00_RS09130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COP00_RS09135	COG0281	malic enzyme
COP00_RS09140	COG0587	DNA-directed DNA polymerase activity
COP00_RS09175	COG1695	Transcriptional regulator
COP00_RS09180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
COP00_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS09190	COG0165	Argininosuccinate lyase
COP00_RS09195	COG0137	argininosuccinate synthase activity
COP00_RS09200	COG0521	Mo-molybdopterin cofactor biosynthetic process
COP00_RS09205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
COP00_RS09210	COG0827	DNA restriction-modification system
COP00_RS09215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
COP00_RS09220	COG3874	Sporulation protein YtfJ
COP00_RS09230	COG1714	RDD family
COP00_RS09235	COG0616	signal peptide processing
COP00_RS09240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COP00_RS09250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
COP00_RS09260	COG0301	tRNA thio-modification
COP00_RS09270	COG1114	Component of the transport system for branched-chain amino acids
COP00_RS09275	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
COP00_RS09285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
COP00_RS09290	COG1309	transcriptional regulator
COP00_RS09295	COG1956	GAF domain-containing protein
COP00_RS09300	COG2199	diguanylate cyclase activity
COP00_RS09300	COG2203	Gaf domain
COP00_RS09310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COP00_RS09320	COG3152	Membrane
COP00_RS09325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COP00_RS09330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
COP00_RS09335	COG0454	-acetyltransferase
COP00_RS09340	COG0517	IMP dehydrogenase activity
COP00_RS09345	COG0123	including yeast histone deacetylase and acetoin utilization protein
COP00_RS09350	COG1360	Flagellar Motor Protein
COP00_RS09355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
COP00_RS09360	COG1609	Transcriptional regulator
COP00_RS09365	COG1605	Chorismate mutase
COP00_RS09365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
COP00_RS09375	COG3118	belongs to the thioredoxin family
COP00_RS09380	COG4980	gas vesicle protein
COP00_RS09385	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
COP00_RS09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
COP00_RS09395	COG1674	ftsk spoiiie
COP00_RS09400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COP00_RS09405	COG4848	Belongs to the UPF0354 family
COP00_RS09410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS09420	COG1363	Peptidase, m42
COP00_RS09425	COG5584	Small secreted protein
COP00_RS09430	COG0281	malic enzyme
COP00_RS09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS09440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
COP00_RS09450	COG0510	thiamine kinase activity
COP00_RS09455	COG1597	lipid kinase activity
COP00_RS09465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
COP00_RS09470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
COP00_RS09480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
COP00_RS09485	COG2252	PERMEase
COP00_RS09490	COG1349	DNA-binding transcription factor activity
COP00_RS09495	COG1187	pseudouridine synthase activity
COP00_RS09500	COG2244	polysaccharide biosynthetic process
COP00_RS09505	COG2081	HI0933 family
COP00_RS09515	COG1349	DNA-binding transcription factor activity
COP00_RS09520	COG3395	kinase activity
COP00_RS09525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
COP00_RS09545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COP00_RS09560	COG5578	integral membrane protein
COP00_RS09565	COG0673	inositol 2-dehydrogenase activity
COP00_RS09570	COG1653	transport
COP00_RS09575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
COP00_RS09580	COG4209	transmembrane transport
COP00_RS09590	COG1653	transport
COP00_RS09595	COG0395	ABC-type sugar transport system, permease component
COP00_RS09600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
COP00_RS09615	COG0583	DNA-binding transcription factor activity
COP00_RS09620	COG0346	lactoylglutathione lyase activity
COP00_RS09625	COG0495	leucyl-tRNA aminoacylation
COP00_RS09635	COG2814	Major facilitator Superfamily
COP00_RS09655	COG2433	Pfam Transposase IS66
COP00_RS09660	COG0577	efflux transmembrane transporter activity
COP00_RS09665	COG1136	(ABC) transporter
COP00_RS09675	COG1131	(ABC) transporter
COP00_RS09680	COG1725	Transcriptional regulator
COP00_RS09690	COG1242	4 iron, 4 sulfur cluster binding
COP00_RS09695	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
COP00_RS09700	COG1301	dicarboxylic acid transport
COP00_RS09715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
COP00_RS09720	COG0671	phosphoesterase, PA-phosphatase related
COP00_RS09725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COP00_RS09725	COG0438	transferase activity, transferring glycosyl groups
COP00_RS09730	COG0367	asparagine synthase
COP00_RS09735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COP00_RS09740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
COP00_RS09750	COG1506	peptidase
COP00_RS09755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
COP00_RS09760	COG1116	anion transmembrane transporter activity
COP00_RS09765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
COP00_RS09770	COG0494	nUDIX hydrolase
COP00_RS09785	COG4824	toxin secretion phage lysis holin
COP00_RS09790	COG0783	Belongs to the Dps family
COP00_RS09805	COG1854	S-ribosylhomocysteine lyase activity
COP00_RS09810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
COP00_RS09815	COG0288	reversible hydration of carbon dioxide
COP00_RS09820	COG0803	Belongs to the bacterial solute-binding protein 9 family
COP00_RS09825	COG0254	rRNA binding
COP00_RS09830	COG1271	oxidase subunit
COP00_RS09835	COG1294	oxidase, subunit
COP00_RS09850	COG2079	MmgE PrpD family protein
COP00_RS09855	COG1473	amidohydrolase
COP00_RS09860	COG1126	abc transporter atp-binding protein
COP00_RS09865	COG0765	amino acid transport
COP00_RS09870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COP00_RS09875	COG0456	acetyltransferase
COP00_RS09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COP00_RS09885	COG4948	Mandelate Racemase Muconate Lactonizing
COP00_RS09890	COG0318	PFAM AMP-dependent synthetase and ligase
COP00_RS09895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
COP00_RS09905	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
COP00_RS09910	COG1169	isochorismate synthase
COP00_RS09915	COG1575	Belongs to the MenA family. Type 1 subfamily
COP00_RS09920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
COP00_RS10040	COG0789	Transcriptional regulator
COP00_RS10045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
COP00_RS10050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
COP00_RS10070	COG1609	Transcriptional regulator
COP00_RS10075	COG3859	Proton-coupled thiamine transporter YuaJ
COP00_RS10080	COG3764	Sortase (surface protein transpeptidase)
COP00_RS10095	COG0457	Tetratricopeptide repeat
COP00_RS10100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
COP00_RS10105	COG2318	DinB family
COP00_RS10115	COG1454	alcohol dehydrogenase
COP00_RS10120	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS10125	COG1510	regulation of RNA biosynthetic process
COP00_RS10160	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
COP00_RS10200	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
COP00_RS10210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COP00_RS10215	COG0726	polysaccharide deacetylase
COP00_RS10220	COG1408	metallophosphoesterase
COP00_RS10225	COG1968	undecaprenyl-diphosphatase activity
COP00_RS10230	COG0628	permease
COP00_RS10245	COG0840	transmembrane signaling receptor activity
COP00_RS10250	COG0840	transmembrane signaling receptor activity
COP00_RS10265	COG0432	Pfam Uncharacterised protein family UPF0047
COP00_RS10270	COG0366	Alpha amylase catalytic
COP00_RS10275	COG5297	Belongs to the glycosyl hydrolase family 6
COP00_RS10280	COG1253	flavin adenine dinucleotide binding
COP00_RS10285	COG2738	Putative neutral zinc metallopeptidase
COP00_RS10300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
COP00_RS10315	COG0166	Belongs to the GPI family
COP00_RS10320	COG1979	alcohol dehydrogenase
COP00_RS10325	COG2155	Conserved Protein
COP00_RS10330	COG1098	S1 RNA binding domain
COP00_RS10335	COG0436	Aminotransferase
COP00_RS10340	COG1522	sequence-specific DNA binding
COP00_RS10345	COG2267	carboxylic ester hydrolase activity
COP00_RS10355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
COP00_RS10370	COG5018	Exonuclease
COP00_RS10375	COG2814	Major facilitator Superfamily
COP00_RS10380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
COP00_RS10385	COG3011	Protein conserved in bacteria
COP00_RS10395	COG3290	protein histidine kinase activity
COP00_RS10400	COG4565	transcriptional regulatory protein
COP00_RS10405	COG1744	ABC transporter substrate-binding protein PnrA-like
COP00_RS10410	COG3845	ABC transporter
COP00_RS10415	COG4603	Belongs to the binding-protein-dependent transport system permease family
COP00_RS10420	COG1079	Belongs to the binding-protein-dependent transport system permease family
COP00_RS10425	COG1183	phosphatidylcholine synthase activity
COP00_RS10430	COG0586	Pfam SNARE associated Golgi protein
COP00_RS10435	COG0688	phosphatidylethanolamine metabolic process
COP00_RS10440	COG3493	citrate carrier protein
COP00_RS10450	COG2111	Na H antiporter
COP00_RS10450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
COP00_RS10455	COG2111	Na H antiporter
COP00_RS10460	COG1006	Multisubunit Na H antiporter MnhC subunit
COP00_RS10465	COG0651	ATP synthesis coupled electron transport
COP00_RS10470	COG1863	multisubunit Na H antiporter MnhE subunit
COP00_RS10475	COG2212	antiporter activity
COP00_RS10480	COG1320	monovalent cation:proton antiporter activity
COP00_RS10485	COG2050	protein possibly involved in aromatic compounds catabolism
COP00_RS10490	COG2197	response regulator
COP00_RS10495	COG4585	Histidine kinase
COP00_RS10505	COG0142	geranyltranstransferase activity
COP00_RS10525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
COP00_RS10530	COG1335	isochorismatase
COP00_RS10535	COG5506	Protein of unknown function (DUF1694)
COP00_RS10550	COG0628	permease
COP00_RS10570	COG1418	mRNA catabolic process
COP00_RS10575	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS10590	COG1511	domain protein
COP00_RS10595	COG0433	COG0433 Predicted ATPase
COP00_RS10595	COG1674	ftsk spoiiie
COP00_RS10600	COG4499	WXG100 protein secretion system (Wss), protein YukC
COP00_RS10605	COG5417	Belongs to the EsaB family
COP00_RS10610	COG4842	Belongs to the WXG100 family
COP00_RS10615	COG2508	Transcriptional regulator
COP00_RS10615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
COP00_RS10620	COG0686	Belongs to the AlaDH PNT family
COP00_RS10625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
COP00_RS10630	COG1268	BioY protein
COP00_RS10635	COG2056	Na+-H+ antiporter family
COP00_RS10640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
COP00_RS10645	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
COP00_RS10650	COG3584	3D domain protein
COP00_RS10660	COG1252	NADH dehydrogenase
COP00_RS10670	COG0492	ferredoxin-NADP+ reductase activity
COP00_RS10700	COG0316	Belongs to the HesB IscA family
COP00_RS10705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COP00_RS10710	COG4844	belongs to the
COP00_RS10715	COG1252	NADH dehydrogenase
COP00_RS10730	COG0457	Tetratricopeptide repeat
COP00_RS10735	COG3479	Phenolic acid decarboxylase
COP00_RS10745	COG4837	Protein of unknown function (DUF1462)
COP00_RS10750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
COP00_RS10760	COG0083	homoserine kinase activity
COP00_RS10765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
COP00_RS10770	COG0460	homoserine dehydrogenase
COP00_RS10775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COP00_RS10780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
COP00_RS10785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
COP00_RS10790	COG0647	UMP catabolic process
COP00_RS10795	COG2445	Protein of unknown function DUF86
COP00_RS10800	COG4470	Protein conserved in bacteria
COP00_RS10815	COG0739	heme binding
COP00_RS10825	COG3377	Domain of unknown function (DUF1805)
COP00_RS10830	COG0737	Belongs to the 5'-nucleotidase family
COP00_RS10835	COG0730	response to heat
COP00_RS10840	COG1801	Protein of unknown function DUF72
COP00_RS10850	COG3226	Transcriptional regulator
COP00_RS10855	COG2814	Major facilitator Superfamily
COP00_RS10860	COG2356	endonuclease I
COP00_RS10865	COG3842	ATPase activity
COP00_RS10870	COG2188	Transcriptional regulator
COP00_RS10875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COP00_RS10880	COG0395	ABC-type sugar transport system, permease component
COP00_RS10885	COG1175	transmembrane transport
COP00_RS10890	COG1653	transport
COP00_RS10895	COG2222	sugar isomerase
COP00_RS10915	COG2068	MobA-Related Protein
COP00_RS10920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
COP00_RS10925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
COP00_RS10945	COG0719	Fe-S assembly protein
COP00_RS10950	COG0822	iron-sulfur transferase activity
COP00_RS10955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COP00_RS10960	COG0719	Fe-S assembly protein
COP00_RS10965	COG0396	ATPase activity
COP00_RS10975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
COP00_RS10980	COG1464	Belongs to the NlpA lipoprotein family
COP00_RS10985	COG2011	ABC-type metal ion transport system permease component
COP00_RS10990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COP00_RS11000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS11005	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COP00_RS11015	COG0509	glycine decarboxylation via glycine cleavage system
COP00_RS11020	COG1393	Belongs to the ArsC family
COP00_RS11025	COG1960	acyl-CoA dehydrogenase activity
COP00_RS11030	COG0183	Belongs to the thiolase family
COP00_RS11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
COP00_RS11035	COG1024	Enoyl-CoA hydratase
COP00_RS11050	COG5577	PFAM Coat F domain
COP00_RS11065	COG1120	ATPase activity
COP00_RS11070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS11075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS11080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS11095	COG1686	Belongs to the peptidase S11 family
COP00_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS11105	COG0783	Belongs to the Dps family
COP00_RS11110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COP00_RS11115	COG0745	RESPONSE REGULATOR receiver
COP00_RS11120	COG2770	Histidine kinase
COP00_RS11120	COG2205	protein histidine kinase activity
COP00_RS11130	COG1309	transcriptional regulator
COP00_RS11135	COG0114	fumarate hydratase activity
COP00_RS11145	COG0697	spore germination
COP00_RS11150	COG0814	amino acid
COP00_RS11165	COG2197	response regulator
COP00_RS11170	COG4585	Histidine kinase
COP00_RS11175	COG4758	membrane
COP00_RS11185	COG1842	Phage shock protein A
COP00_RS11190	COG4758	membrane
COP00_RS11195	COG4677	pectinesterase activity
COP00_RS11210	COG0297	glycogen (starch) synthase activity
COP00_RS11215	COG2096	Adenosyltransferase
COP00_RS11220	COG1120	ATPase activity
COP00_RS11225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS11230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS11240	COG2258	MOSC domain
COP00_RS11245	COG0583	DNA-binding transcription factor activity
COP00_RS11260	COG0246	Mannitol dehydrogenase
COP00_RS11265	COG1609	Transcriptional regulator
COP00_RS11275	COG1904	glucuronate isomerase
COP00_RS11280	COG2205	protein histidine kinase activity
COP00_RS11285	COG0745	RESPONSE REGULATOR receiver
COP00_RS11290	COG1120	ATPase activity
COP00_RS11295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS11300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS11305	COG0531	amino acid
COP00_RS11315	COG1988	membrane-bound metal-dependent
COP00_RS11320	COG1368	sulfuric ester hydrolase activity
COP00_RS11325	COG2814	Major facilitator Superfamily
COP00_RS11330	COG0656	L-ascorbic acid biosynthetic process
COP00_RS11335	COG1940	carbohydrate kinase activity
COP00_RS11345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
COP00_RS11355	COG3973	AAA domain
COP00_RS11360	COG2860	membrane
COP00_RS11365	COG0456	acetyltransferase
COP00_RS11365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
COP00_RS11370	COG0456	acetyltransferase
COP00_RS11375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
COP00_RS11380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
COP00_RS11385	COG2217	Heavy metal translocating P-type atpase
COP00_RS11395	COG1175	transmembrane transport
COP00_RS11400	COG0395	ABC-type sugar transport system, permease component
COP00_RS11405	COG1501	Belongs to the glycosyl hydrolase 31 family
COP00_RS11410	COG1472	Belongs to the glycosyl hydrolase 3 family
COP00_RS11415	COG1121	(ABC) transporter
COP00_RS11420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
COP00_RS11425	COG0803	Belongs to the bacterial solute-binding protein 9 family
COP00_RS11440	COG1105	Belongs to the carbohydrate kinase PfkB family
COP00_RS11445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
COP00_RS11445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
COP00_RS11445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS11460	COG2217	Heavy metal translocating P-type atpase
COP00_RS11465	COG2608	mercury ion transmembrane transporter activity
COP00_RS11470	COG1937	Protein conserved in bacteria
COP00_RS11475	COG0693	protein deglycase activity
COP00_RS11480	COG1349	DNA-binding transcription factor activity
COP00_RS11485	COG1070	Carbohydrate kinase
COP00_RS11490	COG4952	isomerase
COP00_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS11500	COG3347	Dehydrogenase
COP00_RS11505	COG2814	Major facilitator Superfamily
COP00_RS11510	COG3340	Belongs to the peptidase S51 family
COP00_RS11515	COG2814	Major facilitator Superfamily
COP00_RS11520	COG1846	Transcriptional regulator
COP00_RS11525	COG1819	glycosyl
COP00_RS11530	COG0673	inositol 2-dehydrogenase activity
COP00_RS11535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
COP00_RS11540	COG1054	Belongs to the UPF0176 family
COP00_RS11550	COG1191	sigma factor activity
COP00_RS11560	COG2140	Oxalate decarboxylase
COP00_RS11575	COG5520	Belongs to the glycosyl hydrolase 30 family
COP00_RS11580	COG3507	Belongs to the glycosyl hydrolase 43 family
COP00_RS11630	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS11645	COG3953	SLT domain
COP00_RS11645	COG5280	Phage tail tape measure protein TP901
COP00_RS11705	COG1802	Transcriptional regulator
COP00_RS11705	COG4626	Terminase
COP00_RS11750	COG1598	PFAM Uncharacterised protein family UPF0150
COP00_RS11755	COG0582	viral genome integration into host DNA
COP00_RS11865	COG1396	sequence-specific DNA binding
COP00_RS11875	COG0582	viral genome integration into host DNA
COP00_RS11885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
COP00_RS11895	COG1647	Serine aminopeptidase, S33
COP00_RS11900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
COP00_RS11905	COG2002	toxin-antitoxin pair type II binding
COP00_RS11910	COG1476	TRANSCRIPTIONal
COP00_RS11915	COG1396	sequence-specific DNA binding
COP00_RS11920	COG1396	sequence-specific DNA binding
COP00_RS11925	COG1174	glycine betaine transport
COP00_RS11930	COG1732	Glycine betaine
COP00_RS11935	COG1174	glycine betaine transport
COP00_RS11940	COG0517	IMP dehydrogenase activity
COP00_RS11940	COG1125	glycine betaine transport
COP00_RS11945	COG1510	regulation of RNA biosynthetic process
COP00_RS11950	COG2095	MarC family integral membrane protein
COP00_RS11955	COG3064	Membrane
COP00_RS11960	COG4640	response to antibiotic
COP00_RS11965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS11980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COP00_RS11985	COG0149	triose-phosphate isomerase activity
COP00_RS11990	COG0126	phosphoglycerate kinase activity
COP00_RS11995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
COP00_RS12000	COG2390	Transcriptional regulator
COP00_RS12010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COP00_RS12015	COG1113	amino acid transport
COP00_RS12025	COG1881	PFAM PEBP family protein
COP00_RS12030	COG0583	DNA-binding transcription factor activity
COP00_RS12045	COG2197	response regulator
COP00_RS12055	COG1131	(ABC) transporter
COP00_RS12065	COG0789	Transcriptional regulator
COP00_RS12065	COG4978	Transcriptional regulator
COP00_RS12080	COG1139	Iron-sulfur cluster binding protein
COP00_RS12085	COG0247	lactate metabolic process
COP00_RS12090	COG2186	Transcriptional regulator
COP00_RS12095	COG1620	l-lactate permease
COP00_RS12100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
COP00_RS12110	COG5039	Polysaccharide pyruvyl transferase
COP00_RS12115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
COP00_RS12120	COG0110	maltose O-acetyltransferase activity
COP00_RS12125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
COP00_RS12130	COG2244	polysaccharide biosynthetic process
COP00_RS12135	COG1216	Glycosyl transferase, family 2
COP00_RS12140	COG5039	Polysaccharide pyruvyl transferase
COP00_RS12145	COG1216	Glycosyl transferase, family 2
COP00_RS12155	COG0438	transferase activity, transferring glycosyl groups
COP00_RS12160	COG1215	transferase activity, transferring glycosyl groups
COP00_RS12165	COG0438	transferase activity, transferring glycosyl groups
COP00_RS12170	COG1086	Polysaccharide biosynthesis protein
COP00_RS12175	COG0489	protein tyrosine kinase activity
COP00_RS12180	COG3944	biosynthesis protein
COP00_RS12185	COG1396	sequence-specific DNA binding
COP00_RS12190	COG2249	NAD(P)H dehydrogenase (quinone) activity
COP00_RS12195	COG2271	Major facilitator Superfamily
COP00_RS12205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
COP00_RS12220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COP00_RS12230	COG1733	regulation of RNA biosynthetic process
COP00_RS12235	COG1902	pentaerythritol trinitrate reductase activity
COP00_RS12240	COG1621	beta-fructofuranosidase activity
COP00_RS12245	COG1621	beta-fructofuranosidase activity
COP00_RS12265	COG0457	Tetratricopeptide repeat
COP00_RS12270	COG5444	nuclease activity
COP00_RS12310	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS12310	COG5632	N-Acetylmuramoyl-L-alanine amidase
COP00_RS12310	COG1388	LysM domain
COP00_RS12330	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS12345	COG3953	SLT domain
COP00_RS12345	COG5280	Phage tail tape measure protein TP901
COP00_RS12390	COG0740	serine-type endopeptidase activity
COP00_RS12460	COG1793	dna ligase
COP00_RS12520	COG3584	3D domain protein
COP00_RS12525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
COP00_RS12535	COG0756	dUTP diphosphatase activity
COP00_RS12545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS12560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS12565	COG1780	Probably involved in ribonucleotide reductase function
COP00_RS12590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
COP00_RS12605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS12605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS12640	COG1396	sequence-specific DNA binding
COP00_RS12720	COG4974	Belongs to the 'phage' integrase family
COP00_RS12730	COG0740	serine-type endopeptidase activity
COP00_RS12745	COG1694	Mazg nucleotide pyrophosphohydrolase
COP00_RS12750	COG1078	dGTPase activity
COP00_RS12755	COG0659	secondary active sulfate transmembrane transporter activity
COP00_RS12760	COG0288	reversible hydration of carbon dioxide
COP00_RS12765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COP00_RS12770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
COP00_RS12775	COG0640	Transcriptional regulator
COP00_RS12780	COG0577	efflux transmembrane transporter activity
COP00_RS12785	COG1136	(ABC) transporter
COP00_RS12790	COG5002	protein histidine kinase activity
COP00_RS12795	COG0745	RESPONSE REGULATOR receiver
COP00_RS12805	COG2162	N-hydroxyarylamine O-acetyltransferase activity
COP00_RS12810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS12815	COG1481	regulation of sporulation
COP00_RS12820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
COP00_RS12825	COG1660	Displays ATPase and GTPase activities
COP00_RS12830	COG1051	belongs to the nudix hydrolase family
COP00_RS12835	COG0492	ferredoxin-NADP+ reductase activity
COP00_RS12840	COG0457	Tetratricopeptide repeat
COP00_RS12845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
COP00_RS12845	COG0140	phosphoribosyl-ATP diphosphatase activity
COP00_RS12850	COG0107	imidazoleglycerol-phosphate synthase activity
COP00_RS12855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
COP00_RS12860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
COP00_RS12865	COG0131	Imidazoleglycerol-phosphate dehydratase
COP00_RS12870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
COP00_RS12875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
COP00_RS12880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
COP00_RS12885	COG4990	cell redox homeostasis
COP00_RS12895	COG5297	Belongs to the glycosyl hydrolase family 6
COP00_RS12900	COG0110	maltose O-acetyltransferase activity
COP00_RS12905	COG0546	phosphoglycolate phosphatase activity
COP00_RS12910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
COP00_RS12915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
COP00_RS12920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
COP00_RS12925	COG1846	Transcriptional regulator
COP00_RS12930	COG2814	Major facilitator Superfamily
COP00_RS12935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
COP00_RS12940	COG1950	PFAM Membrane protein of
COP00_RS12950	COG3595	metallopeptidase activity
COP00_RS12965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
COP00_RS12970	COG0556	nucleotide-excision repair
COP00_RS12975	COG4897	Protein conserved in bacteria
COP00_RS12995	COG0793	Belongs to the peptidase S41A family
COP00_RS12995	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS13000	COG0473	3-isopropylmalate dehydrogenase activity
COP00_RS13005	COG0791	NLP P60 protein
COP00_RS13005	COG3883	PFAM NLP P60 protein
COP00_RS13010	COG2177	Part of the ABC transporter FtsEX involved in
COP00_RS13015	COG2884	Cell division ATP-binding protein ftsE
COP00_RS13020	COG2010	Cytochrome c
COP00_RS13025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS13035	COG0653	protein targeting
COP00_RS13040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
COP00_RS13055	COG1516	flagellar protein fliS
COP00_RS13060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
COP00_RS13065	COG1334	flagellar protein FlaG
COP00_RS13070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
COP00_RS13075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
COP00_RS13080	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
COP00_RS13090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
COP00_RS13095	COG4786	Flagellar basal body rod
COP00_RS13095	COG1256	bacterial-type flagellum assembly
COP00_RS13100	COG3418	PFAM FlgN family protein
COP00_RS13105	COG2747	anti-sigma28 factor FlgM
COP00_RS13115	COG1040	competence protein
COP00_RS13125	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
COP00_RS13130	COG1307	EDD domain protein, DegV family
COP00_RS13135	COG2197	response regulator
COP00_RS13140	COG4585	Histidine kinase
COP00_RS13145	COG1739	Uncharacterized protein family UPF0029
COP00_RS13150	COG1316	TRANSCRIPTIONal
COP00_RS13155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COP00_RS13160	COG0438	transferase activity, transferring glycosyl groups
COP00_RS13165	COG1215	transferase activity, transferring glycosyl groups
COP00_RS13170	COG3206	protein involved in exopolysaccharide biosynthesis
COP00_RS13175	COG3307	-O-antigen
COP00_RS13180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
COP00_RS13185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
COP00_RS13190	COG0438	transferase activity, transferring glycosyl groups
COP00_RS13190	COG0297	glycogen (starch) synthase activity
COP00_RS13195	COG2244	polysaccharide biosynthetic process
COP00_RS13205	COG0860	N-Acetylmuramoyl-L-alanine amidase
COP00_RS13205	COG2247	cell wall binding repeat
COP00_RS13210	COG2385	sporulation resulting in formation of a cellular spore
COP00_RS13210	COG2247	cell wall binding repeat
COP00_RS13220	COG1316	TRANSCRIPTIONal
COP00_RS13225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
COP00_RS13230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
COP00_RS13235	COG1134	teichoic acid transport
COP00_RS13240	COG1682	transport, permease protein
COP00_RS13245	COG1215	transferase activity, transferring glycosyl groups
COP00_RS13260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
COP00_RS13270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
COP00_RS13275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
COP00_RS13285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
COP00_RS13290	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
COP00_RS13295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
COP00_RS13300	COG4193	domain, Protein
COP00_RS13305	COG1482	cell wall glycoprotein biosynthetic process
COP00_RS13315	COG1328	CTP reductase activity
COP00_RS13325	COG0800	Aldolase
COP00_RS13330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COP00_RS13335	COG1609	Transcriptional regulator
COP00_RS13340	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
COP00_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS13350	COG1063	alcohol dehydrogenase
COP00_RS13355	COG2814	Major facilitator Superfamily
COP00_RS13360	COG1316	TRANSCRIPTIONal
COP00_RS13365	COG0561	phosphatase activity
COP00_RS13370	COG0791	NLP P60 protein
COP00_RS13380	COG2843	Capsule synthesis protein
COP00_RS13390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COP00_RS13395	COG1609	Transcriptional regulator
COP00_RS13400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COP00_RS13405	COG1869	D-ribose catabolic process
COP00_RS13410	COG1129	ABC transporter
COP00_RS13415	COG1172	Belongs to the binding-protein-dependent transport system permease family
COP00_RS13420	COG1879	ABC-type sugar transport system periplasmic component
COP00_RS13425	COG0583	DNA-binding transcription factor activity
COP00_RS13430	COG2226	methyltransferase
COP00_RS13435	COG3527	Alpha-acetolactate decarboxylase
COP00_RS13440	COG0028	Belongs to the TPP enzyme family
COP00_RS13455	COG1522	sequence-specific DNA binding
COP00_RS13460	COG2059	Chromate
COP00_RS13465	COG2059	Chromate
COP00_RS13470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
COP00_RS13475	COG4464	protein tyrosine phosphatase activity
COP00_RS13480	COG3944	biosynthesis protein
COP00_RS13490	COG4715	Zinc finger, swim domain protein
COP00_RS13495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
COP00_RS13500	COG0831	urea catabolic process
COP00_RS13505	COG0832	Belongs to the urease beta subunit family
COP00_RS13510	COG0804	urea catabolic process
COP00_RS13515	COG0561	phosphatase activity
COP00_RS13520	COG1349	DNA-binding transcription factor activity
COP00_RS13525	COG0629	single-stranded DNA binding
COP00_RS13540	COG1970	mechanosensitive ion channel activity
COP00_RS13545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COP00_RS13550	COG4786	Flagellar basal body rod
COP00_RS13555	COG4786	Flagellar basal body rod
COP00_RS13560	COG1077	Cell shape determining protein MreB Mrl
COP00_RS13565	COG1609	Transcriptional regulator
COP00_RS13575	COG1846	Transcriptional regulator
COP00_RS13580	COG2814	Major facilitator Superfamily
COP00_RS13585	COG0671	phosphoesterase, PA-phosphatase related
COP00_RS13590	COG1227	inorganic diphosphatase activity
COP00_RS13600	COG3361	conserved protein (COG2071)
COP00_RS13605	COG0517	IMP dehydrogenase activity
COP00_RS13610	COG0598	Magnesium transport protein CorA
COP00_RS13615	COG1253	flavin adenine dinucleotide binding
COP00_RS13620	COG0004	ammonium transporteR
COP00_RS13625	COG0347	Belongs to the P(II) protein family
COP00_RS13635	COG0740	serine-type endopeptidase activity
COP00_RS13645	COG0739	heme binding
COP00_RS13650	COG1247	-acetyltransferase
COP00_RS13660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COP00_RS13665	COG0477	Major facilitator Superfamily
COP00_RS13670	COG3251	PFAM MbtH domain protein
COP00_RS13680	COG3433	isochorismatase activity
COP00_RS13680	COG1535	isochorismatase
COP00_RS13685	COG1021	2,3-dihydroxybenzoate-AMP ligase
COP00_RS13690	COG1169	isochorismate synthase
COP00_RS13700	COG2819	hydrolase of the alpha beta superfamily
COP00_RS13705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS13710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS13715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS13720	COG2207	Transcriptional regulator
COP00_RS13720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS13730	COG2910	NAD(P)H-binding
COP00_RS13735	COG1959	2 iron, 2 sulfur cluster binding
COP00_RS13745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
COP00_RS13750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
COP00_RS13755	COG2223	nitrite transmembrane transporter activity
COP00_RS13765	COG2304	oxidoreductase activity
COP00_RS13770	COG2304	oxidoreductase activity
COP00_RS13775	COG2385	sporulation resulting in formation of a cellular spore
COP00_RS13780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COP00_RS13790	COG4836	Membrane
COP00_RS13795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
COP00_RS13800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COP00_RS13805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COP00_RS13810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COP00_RS13815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COP00_RS13820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COP00_RS13825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COP00_RS13845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
COP00_RS13850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COP00_RS13855	COG4475	Protein of unknown function (DUF436)
COP00_RS13860	COG0698	ribose 5-phosphate isomerase
COP00_RS13865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COP00_RS13870	COG1971	Probably functions as a manganese efflux pump
COP00_RS13875	COG0009	L-threonylcarbamoyladenylate synthase
COP00_RS13880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
COP00_RS13890	COG0738	Major facilitator superfamily
COP00_RS13895	COG0673	inositol 2-dehydrogenase activity
COP00_RS13900	COG0561	phosphatase activity
COP00_RS13905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
COP00_RS13910	COG1609	Transcriptional regulator
COP00_RS13915	COG2890	protein-(glutamine-N5) methyltransferase activity
COP00_RS13920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COP00_RS13925	COG0346	lactoylglutathione lyase activity
COP00_RS13930	COG0789	Transcriptional regulator
COP00_RS13935	COG0679	Auxin Efflux Carrier
COP00_RS13940	COG0281	malic enzyme
COP00_RS13945	COG1435	thymidine kinase activity
COP00_RS13955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
COP00_RS13960	COG1494	fructose-1,6-bisphosphatase
COP00_RS13965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COP00_RS13970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
COP00_RS13975	COG0191	fructose-bisphosphate aldolase activity
COP00_RS13980	COG2204	response regulator
COP00_RS13985	COG4821	SIS domain
COP00_RS13990	COG0504	CTP synthase activity
COP00_RS13995	COG3343	RNA polymerase activity
COP00_RS14005	COG1960	acyl-CoA dehydrogenase activity
COP00_RS14010	COG1960	acyl-CoA dehydrogenase activity
COP00_RS14015	COG1250	3-hydroxyacyl-CoA dehydrogenase
COP00_RS14020	COG0183	Belongs to the thiolase family
COP00_RS14025	COG2181	nitrate reductase activity
COP00_RS14025	COG0247	lactate metabolic process
COP00_RS14040	COG0018	arginyl-trna synthetase
COP00_RS14045	COG4506	Protein conserved in bacteria
COP00_RS14050	COG0010	Belongs to the arginase family
COP00_RS14055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
COP00_RS14060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
COP00_RS14070	COG1994	Peptidase M50
COP00_RS14075	COG1942	4-Oxalocrotonate Tautomerase
COP00_RS14085	COG3465	dGTPase activity
COP00_RS14090	COG1078	dGTPase activity
COP00_RS14095	COG4844	belongs to the
COP00_RS14120	COG2814	Major facilitator Superfamily
COP00_RS14145	COG1414	Transcriptional regulator
COP00_RS14155	COG0280	phosphate acetyltransferase
COP00_RS14160	COG3253	May function as heme-dependent peroxidase
COP00_RS14185	COG1131	(ABC) transporter
COP00_RS14195	COG2197	response regulator
COP00_RS14200	COG2363	Small membrane protein
COP00_RS14205	COG2233	PERMEase
COP00_RS14215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
COP00_RS14220	COG1216	Glycosyl transferase, family 2
COP00_RS14225	COG0351	phosphomethylpyrimidine kinase
COP00_RS14235	COG1621	beta-fructofuranosidase activity
COP00_RS14240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS14240	COG1263	PTS System
COP00_RS14245	COG3711	transcriptional antiterminator
COP00_RS14255	COG1404	Belongs to the peptidase S8 family
COP00_RS14265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COP00_RS14270	COG0778	Nitroreductase
COP00_RS14275	COG1473	amidohydrolase
COP00_RS14280	COG0772	Belongs to the SEDS family
COP00_RS14285	COG0772	Belongs to the SEDS family
COP00_RS14335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
COP00_RS14345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
COP00_RS14350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
COP00_RS14355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
COP00_RS14375	COG0655	NAD(P)H dehydrogenase (quinone) activity
COP00_RS14380	COG3162	membrane
COP00_RS14385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COP00_RS14390	COG1070	Carbohydrate kinase
COP00_RS14395	COG2115	Belongs to the xylose isomerase family
COP00_RS14405	COG0352	thiamine-phosphate diphosphorylase activity
COP00_RS14410	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
COP00_RS14415	COG0583	DNA-binding transcription factor activity
COP00_RS14430	COG1380	Effector of murein hydrolase LrgA
COP00_RS14435	COG1346	cytolysis
COP00_RS14440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COP00_RS14445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
COP00_RS14450	COG0346	lactoylglutathione lyase activity
COP00_RS14455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COP00_RS14460	COG1442	glycosyl transferase family 8
COP00_RS14465	COG5522	Integral membrane protein (intg_mem_TP0381)
COP00_RS14470	COG2271	Major facilitator Superfamily
COP00_RS14475	COG4948	Mandelate Racemase Muconate Lactonizing
COP00_RS14480	COG0800	Aldolase
COP00_RS14485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COP00_RS14490	COG1414	Transcriptional regulator
COP00_RS14495	COG2234	aminopeptidase activity
COP00_RS14515	COG0477	Major facilitator Superfamily
COP00_RS14520	COG1335	isochorismatase
COP00_RS14525	COG2357	RelA SpoT domain protein
COP00_RS14540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COP00_RS14545	COG1696	Membrane protein involved in D-alanine export
COP00_RS14550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
COP00_RS14555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
COP00_RS14560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
COP00_RS14565	COG2814	Major facilitator Superfamily
COP00_RS14570	COG1486	melibiose metabolic process
COP00_RS14575	COG1447	Phosphotransferase system cellobiose-specific component IIA
COP00_RS14580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS14585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS14590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS14590	COG3711	transcriptional antiterminator
COP00_RS14595	COG2094	Belongs to the DNA glycosylase MPG family
COP00_RS14620	COG0372	Belongs to the citrate synthase family
COP00_RS14625	COG2079	MmgE PrpD family protein
COP00_RS14630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
COP00_RS14635	COG1132	(ABC) transporter
COP00_RS14640	COG2755	lipolytic protein G-D-S-L family
COP00_RS14660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
COP00_RS14665	COG1131	(ABC) transporter
COP00_RS14685	COG1595	DNA-templated transcription, initiation
COP00_RS14690	COG2814	Major facilitator Superfamily
COP00_RS14700	COG0753	catalase activity
COP00_RS14710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
COP00_RS14720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
COP00_RS14725	COG2311	Membrane
COP00_RS14730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
COP00_RS14735	COG4988	ABC transporter
COP00_RS14740	COG1294	oxidase, subunit
COP00_RS14745	COG1271	oxidase subunit
COP00_RS14750	COG3001	Fructosamine kinase
COP00_RS14755	COG2116	formate transmembrane transporter activity
COP00_RS14765	COG0281	malic enzyme
COP00_RS14770	COG1757	Na H antiporter
COP00_RS14775	COG1027	Aspartate ammonia-lyase
COP00_RS14780	COG0252	asparaginase activity
COP00_RS14785	COG1396	sequence-specific DNA binding
COP00_RS14790	COG2706	6-phosphogluconolactonase activity
COP00_RS14795	COG0745	RESPONSE REGULATOR receiver
COP00_RS14800	COG2205	protein histidine kinase activity
COP00_RS14805	COG1136	(ABC) transporter
COP00_RS14810	COG0577	efflux transmembrane transporter activity
COP00_RS14815	COG5294	Protein conserved in bacteria
COP00_RS14830	COG0726	polysaccharide deacetylase
COP00_RS14835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS14850	COG3493	citrate carrier protein
COP00_RS14855	COG0584	glycerophosphoryl diester phosphodiesterase
COP00_RS14875	COG5444	nuclease activity
COP00_RS14885	COG1368	sulfuric ester hydrolase activity
COP00_RS14900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS14905	COG1438	arginine binding
COP00_RS14915	COG2235	arginine
COP00_RS14920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COP00_RS14930	COG0549	Belongs to the carbamate kinase family
COP00_RS14955	COG0745	RESPONSE REGULATOR receiver
COP00_RS14960	COG2205	protein histidine kinase activity
COP00_RS14965	COG2723	6-phospho-beta-galactosidase activity
COP00_RS14970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
COP00_RS14980	COG2195	Cleaves the N-terminal amino acid of tripeptides
COP00_RS14990	COG1621	beta-fructofuranosidase activity
COP00_RS14995	COG2223	nitrite transmembrane transporter activity
COP00_RS15000	COG1609	Transcriptional regulator
COP00_RS15015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
COP00_RS15020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
COP00_RS15025	COG0463	Glycosyl transferase, family 2
COP00_RS15030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
COP00_RS15040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
COP00_RS15045	COG1476	TRANSCRIPTIONal
COP00_RS15055	COG0693	protein deglycase activity
COP00_RS15055	COG0753	catalase activity
COP00_RS15060	COG2851	Citrate transporter
COP00_RS15065	COG2723	6-phospho-beta-galactosidase activity
COP00_RS15070	COG2190	(PTS) system
COP00_RS15070	COG1263	PTS System
COP00_RS15070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS15075	COG3711	transcriptional antiterminator
COP00_RS15080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
COP00_RS15085	COG1122	ATPase activity
COP00_RS15095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
COP00_RS15105	COG2224	Isocitrate lyase
COP00_RS15110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
COP00_RS15125	COG0577	efflux transmembrane transporter activity
COP00_RS15130	COG1136	(ABC) transporter
COP00_RS15135	COG2205	protein histidine kinase activity
COP00_RS15140	COG0745	RESPONSE REGULATOR receiver
COP00_RS15145	COG2723	6-phospho-beta-galactosidase activity
COP00_RS15150	COG1263	PTS System
COP00_RS15150	COG2190	(PTS) system
COP00_RS15150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS15160	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
COP00_RS15165	COG3507	Belongs to the glycosyl hydrolase 43 family
COP00_RS15170	COG0513	Belongs to the DEAD box helicase family
COP00_RS15180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
COP00_RS15185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
COP00_RS15190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
COP00_RS15195	COG2390	Transcriptional regulator
COP00_RS15200	COG0457	Tetratricopeptide repeat
COP00_RS15205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
COP00_RS15210	COG3706	GGDEF domain
COP00_RS15215	COG5298	Protein conserved in bacteria
COP00_RS15220	COG1215	transferase activity, transferring glycosyl groups
COP00_RS15245	COG1181	Belongs to the D-alanine--D-alanine ligase family
COP00_RS15255	COG0191	fructose-bisphosphate aldolase activity
COP00_RS15260	COG1082	Xylose isomerase domain protein TIM barrel
COP00_RS15265	COG1082	Xylose isomerase domain protein TIM barrel
COP00_RS15270	COG0673	inositol 2-dehydrogenase activity
COP00_RS15275	COG2814	Major facilitator Superfamily
COP00_RS15280	COG1082	Xylose isomerase domain protein TIM barrel
COP00_RS15285	COG3962	Belongs to the TPP enzyme family
COP00_RS15290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COP00_RS15295	COG3718	enzyme involved in inositol metabolism
COP00_RS15300	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS15305	COG1349	DNA-binding transcription factor activity
COP00_RS15310	COG0667	Aldo Keto reductase
COP00_RS15320	COG2271	Major facilitator Superfamily
COP00_RS15325	COG0326	Molecular chaperone. Has ATPase activity
COP00_RS15330	COG0488	(ABC) transporter
COP00_RS15335	COG0561	phosphatase activity
COP00_RS15355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS15385	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
COP00_RS15390	COG0577	efflux transmembrane transporter activity
COP00_RS15395	COG1136	(ABC) transporter
COP00_RS15400	COG2205	protein histidine kinase activity
COP00_RS15405	COG0745	RESPONSE REGULATOR receiver
COP00_RS15420	COG3867	Arabinogalactan endo-beta-1,4-galactanase
COP00_RS15425	COG1874	Beta-galactosidase
COP00_RS15430	COG3833	ABC-type maltose transport systems, permease component
COP00_RS15435	COG1175	transmembrane transport
COP00_RS15440	COG2182	Extracellular solute-binding protein
COP00_RS15445	COG1609	Transcriptional regulator
COP00_RS15455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
COP00_RS15465	COG1940	carbohydrate kinase activity
COP00_RS15470	COG1802	Transcriptional regulator
COP00_RS15475	COG1070	Carbohydrate kinase
COP00_RS15490	COG1454	alcohol dehydrogenase
COP00_RS15490	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS15500	COG0450	alkyl hydroperoxide reductase
COP00_RS15505	COG3634	alkyl hydroperoxide reductase activity
COP00_RS15510	COG1113	amino acid transport
COP00_RS15535	COG5002	protein histidine kinase activity
COP00_RS15540	COG0745	RESPONSE REGULATOR receiver
COP00_RS15570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
COP00_RS15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS15610	COG1131	(ABC) transporter
COP00_RS15615	COG0842	Transport permease protein
COP00_RS15620	COG4585	Histidine kinase
COP00_RS15625	COG2197	response regulator
COP00_RS15670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
COP00_RS15685	COG0456	acetyltransferase
COP00_RS15700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COP00_RS15705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
COP00_RS15710	COG4853	Protein conserved in bacteria
COP00_RS15715	COG4863	YycH protein
COP00_RS15720	COG5002	protein histidine kinase activity
COP00_RS15725	COG0745	RESPONSE REGULATOR receiver
COP00_RS15750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COP00_RS15760	COG0305	Participates in initiation and elongation during chromosome replication
COP00_RS15770	COG3093	addiction module antidote protein HigA
COP00_RS15775	COG2807	transmembrane transport
COP00_RS15780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
COP00_RS15785	COG0363	glucosamine-6-phosphate deaminase activity
COP00_RS15790	COG2188	Transcriptional regulator
COP00_RS15795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
COP00_RS15800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS15800	COG1263	PTS System
COP00_RS15805	COG0359	binds to the 23S rRNA
COP00_RS15810	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
COP00_RS15815	COG4241	membrane
COP00_RS15825	COG5577	PFAM Coat F domain
COP00_RS15830	COG0659	secondary active sulfate transmembrane transporter activity
COP00_RS15835	COG2271	Major facilitator Superfamily
COP00_RS15840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COP00_RS15845	COG0629	single-stranded DNA binding
COP00_RS15850	COG0360	Binds together with S18 to 16S ribosomal RNA
COP00_RS15855	COG0012	GTP binding
COP00_RS15860	COG4481	Protein conserved in bacteria
COP00_RS15865	COG3949	Membrane
COP00_RS15875	COG1475	DNA binding
COP00_RS15880	COG1192	Involved in chromosome partitioning
COP00_RS15885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
COP00_RS15890	COG1595	DNA-templated transcription, initiation
COP00_RS15895	COG1475	DNA binding
COP00_RS15900	COG0357	Ribosomal RNA small subunit methyltransferase G
COP00_RS15905	COG0445	tRNA wobble uridine modification
COP00_RS15910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COP00_RS15915	COG1847	R3H domain protein
COP00_RS15920	COG0706	membrane insertase activity
COP00_RS15925	COG0594	ribonuclease P activity
COP00_RS15935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COP00_RS15940	COG0592	DNA-directed DNA polymerase activity
COP00_RS15945	COG2501	S4 domain
COP00_RS15950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
COP00_RS15960	COG0187	DNA topoisomerase II activity
COP00_RS15965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COP00_RS16000	COG0517	IMP dehydrogenase activity
COP00_RS16000	COG0516	GMP reductase activity
COP00_RS16005	COG1686	Belongs to the peptidase S11 family
COP00_RS16010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
COP00_RS16015	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
COP00_RS16020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COP00_RS16025	COG1929	Belongs to the glycerate kinase type-1 family
COP00_RS16035	COG3835	regulator
COP00_RS16040	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
COP00_RS16055	COG1309	transcriptional regulator
COP00_RS16060	COG1428	Deoxynucleoside kinase
COP00_RS16065	COG1428	Deoxynucleoside kinase
COP00_RS16070	COG1388	LysM domain
COP00_RS16070	COG3858	chitin binding
COP00_RS16075	COG1335	isochorismatase
COP00_RS16080	COG0590	tRNA wobble adenosine to inosine editing
COP00_RS16090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COP00_RS16095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COP00_RS16100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
COP00_RS16145	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
COP00_RS16150	COG3853	Toxic anion resistance protein (TelA)
COP00_RS16155	COG1982	Orn Lys Arg decarboxylase major
COP00_RS16160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COP00_RS16165	COG3870	Protein conserved in bacteria
COP00_RS16170	COG1728	Protein conserved in bacteria
COP00_RS16175	COG0470	DNA polymerase III
COP00_RS16180	COG1774	PSP1 C-terminal conserved region
COP00_RS16185	COG4467	Involved in initiation control of chromosome replication
COP00_RS16190	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
COP00_RS16195	COG2827	Endonuclease containing a URI domain
COP00_RS16200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COP00_RS16205	COG2002	toxin-antitoxin pair type II binding
COP00_RS16210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COP00_RS16210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COP00_RS16215	COG0084	hydrolase, TatD family'
COP00_RS16220	COG3584	3D domain protein
COP00_RS16220	COG3583	domain protein
COP00_RS16225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
COP00_RS16230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
COP00_RS16240	COG4466	Protein conserved in bacteria
COP00_RS16250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
COP00_RS16255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
COP00_RS16260	COG0251	oxidation-reduction process
COP00_RS16265	COG2088	sporulation resulting in formation of a cellular spore
COP00_RS16270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COP00_RS16275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COP00_RS16280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
COP00_RS16285	COG0193	aminoacyl-tRNA hydrolase activity
COP00_RS16295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COP00_RS16300	COG2002	toxin-antitoxin pair type II binding
COP00_RS16310	COG3956	TIGRFAM MazG family protein
COP00_RS16315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
COP00_RS16330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
COP00_RS16335	COG1098	S1 RNA binding domain
COP00_RS16350	COG2208	phosphoserine phosphatase activity
COP00_RS16355	COG2304	oxidoreductase activity
COP00_RS16360	COG0515	serine threonine protein kinase
COP00_RS16365	COG0037	tRNA processing
COP00_RS16370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
COP00_RS16375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COP00_RS16385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
COP00_RS16390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COP00_RS16395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
COP00_RS16400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COP00_RS16405	COG0512	Glutamine amidotransferase of anthranilate synthase
COP00_RS16410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
COP00_RS16415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
COP00_RS16420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COP00_RS16425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
COP00_RS16430	COG1396	sequence-specific DNA binding
COP00_RS16435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
COP00_RS16440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
COP00_RS16520	COG4463	regulation of RNA biosynthetic process
COP00_RS16525	COG3880	PFAM UvrB UvrC protein
COP00_RS16530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
COP00_RS16535	COG0542	response to heat
COP00_RS16540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
COP00_RS16545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
COP00_RS16550	COG4956	integral membrane protein (PIN domain superfamily)
COP00_RS16555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
COP00_RS16560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
COP00_RS16565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COP00_RS16570	COG1045	serine acetyltransferase
COP00_RS16575	COG0215	cysteine-tRNA ligase activity
COP00_RS16585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COP00_RS16590	COG3688	RNA-binding protein containing a PIN domain
COP00_RS16600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
COP00_RS16610	COG0250	Participates in transcription elongation, termination and antitermination
COP00_RS16615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COP00_RS16620	COG0081	regulation of translation
COP00_RS16625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COP00_RS16630	COG0222	ribosome binding
COP00_RS16635	COG2813	Specifically methylates the guanine in position
COP00_RS16640	COG0085	RNA polymerase activity
COP00_RS16645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COP00_RS16650	COG1358	cellular component organization or biogenesis
COP00_RS16655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COP00_RS16660	COG0049	tRNA binding
COP00_RS16665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COP00_RS16670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COP00_RS16680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COP00_RS16685	COG0088	Forms part of the polypeptide exit tunnel
COP00_RS16690	COG0089	rRNA binding
COP00_RS16695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COP00_RS16700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COP00_RS16705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COP00_RS16710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COP00_RS16715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COP00_RS16720	COG0255	Belongs to the universal ribosomal protein uL29 family
COP00_RS16725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COP00_RS16730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COP00_RS16735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COP00_RS16740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COP00_RS16745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COP00_RS16750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COP00_RS16755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COP00_RS16760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COP00_RS16765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COP00_RS16775	COG0200	Binds to the 23S rRNA
COP00_RS16780	COG0201	protein transport
COP00_RS16785	COG0563	adenylate kinase activity
COP00_RS16790	COG0024	Methionine aminopeptidase
COP00_RS16795	COG2163	COG2163 Ribosomal protein L14E L6E L27E
COP00_RS16800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COP00_RS16805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
COP00_RS16810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COP00_RS16815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COP00_RS16820	COG0202	RNA polymerase activity
COP00_RS16825	COG0203	ribosomal protein L17
COP00_RS16830	COG1122	ATPase activity
COP00_RS16835	COG1122	ATPase activity
COP00_RS16845	COG0101	tRNA pseudouridine synthase activity
COP00_RS16850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COP00_RS16855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
COP00_RS16875	COG0860	N-Acetylmuramoyl-L-alanine amidase
COP00_RS16880	COG0489	protein tyrosine kinase activity
COP00_RS16890	COG2194	sulfuric ester hydrolase activity
COP00_RS16895	COG0726	polysaccharide deacetylase
COP00_RS16925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
COP00_RS16935	COG0385	Bile acid
COP00_RS16940	COG3876	Protein conserved in bacteria
COP00_RS16945	COG1472	Belongs to the glycosyl hydrolase 3 family
COP00_RS16950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
COP00_RS16955	COG1263	PTS System
COP00_RS16955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS16965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
COP00_RS16970	COG1683	Conserved Protein
COP00_RS17005	COG1595	DNA-templated transcription, initiation
COP00_RS17010	COG5662	AntiSigma factor
COP00_RS17015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
COP00_RS17020	COG4856	YbbR-like protein
COP00_RS17025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COP00_RS17035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
COP00_RS17040	COG5646	InterPro IPR014922
COP00_RS17045	COG0640	Transcriptional regulator
COP00_RS17050	COG2814	Major facilitator Superfamily
COP00_RS17055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
COP00_RS17070	COG1131	(ABC) transporter
COP00_RS17075	COG1725	Transcriptional regulator
COP00_RS17080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS17105	COG0596	Alpha beta hydrolase
COP00_RS17110	COG0745	RESPONSE REGULATOR receiver
COP00_RS17115	COG0642	Histidine kinase
COP00_RS17120	COG1132	(ABC) transporter
COP00_RS17135	COG1131	(ABC) transporter
COP00_RS17145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
COP00_RS17160	COG2312	Erythromycin esterase
COP00_RS17180	COG1011	Hydrolase
COP00_RS17185	COG1113	amino acid transport
COP00_RS17225	COG1331	Highly conserved protein containing a thioredoxin domain
COP00_RS17230	COG1331	Highly conserved protein containing a thioredoxin domain
COP00_RS17235	COG2856	Zn peptidase
COP00_RS17240	COG1396	sequence-specific DNA binding
COP00_RS17265	COG1674	ftsk spoiiie
COP00_RS17270	COG2946	Replication initiation factor
COP00_RS17300	COG0433	COG0433 Predicted ATPase
COP00_RS17315	COG5644	endopeptidase inhibitor activity
COP00_RS17320	COG0791	NLP P60 protein
COP00_RS17320	COG0741	lytic transglycosylase activity
COP00_RS17345	COG0457	Tetratricopeptide repeat
COP00_RS17355	COG1331	Highly conserved protein containing a thioredoxin domain
COP00_RS17370	COG1331	Highly conserved protein containing a thioredoxin domain
COP00_RS17375	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
COP00_RS17390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
COP00_RS17395	COG1331	Highly conserved protein containing a thioredoxin domain
COP00_RS17400	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
COP00_RS17410	COG1733	regulation of RNA biosynthetic process
COP00_RS17415	COG0596	Alpha beta hydrolase
COP00_RS17420	COG2211	Major facilitator Superfamily
COP00_RS17425	COG0860	N-Acetylmuramoyl-L-alanine amidase
COP00_RS17425	COG3103	Sh3 type 3 domain protein
COP00_RS17425	COG4991	sh3 domain protein
COP00_RS17440	COG3764	Sortase (surface protein transpeptidase)
COP00_RS17450	COG2002	toxin-antitoxin pair type II binding
COP00_RS17465	COG0477	Major facilitator Superfamily
COP00_RS17470	COG1794	racemase activity, acting on amino acids and derivatives
COP00_RS17490	COG2226	methyltransferase
COP00_RS17495	COG0076	glutamate decarboxylase activity
COP00_RS17500	COG1846	Transcriptional regulator
COP00_RS17515	COG0778	Nitroreductase
COP00_RS17520	COG1802	Transcriptional regulator
COP00_RS17525	COG0730	response to heat
COP00_RS17540	COG4682	membrane
COP00_RS17560	COG3409	Peptidoglycan-binding domain 1 protein
COP00_RS17570	COG0697	spore germination
COP00_RS17575	COG2207	Transcriptional regulator
COP00_RS17575	COG1917	Cupin 2, conserved barrel domain protein
COP00_RS17590	COG0371	Dehydrogenase
COP00_RS17600	COG4257	antibiotic catabolic process
COP00_RS17615	COG3394	polysaccharide catabolic process
COP00_RS17620	COG1263	PTS System
COP00_RS17620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS17635	COG0531	amino acid
COP00_RS17645	COG2205	protein histidine kinase activity
COP00_RS17650	COG2304	oxidoreductase activity
COP00_RS17655	COG1115	amino acid carrier protein
COP00_RS17660	COG2066	Belongs to the glutaminase family
COP00_RS17665	COG4191	Histidine kinase
COP00_RS17670	COG0784	Response regulator, receiver
COP00_RS17680	COG3540	Alkaline phosphatase
COP00_RS17685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COP00_RS17690	COG0805	protein transport
COP00_RS17695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COP00_RS17700	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS17705	COG2271	Major facilitator Superfamily
COP00_RS17710	COG4948	Mandelate Racemase Muconate Lactonizing
COP00_RS17715	COG2186	Transcriptional regulator
COP00_RS17720	COG2721	sulfolactate sulfo-lyase activity
COP00_RS17750	COG3173	Aminoglycoside phosphotransferase
COP00_RS17755	COG1846	Transcriptional regulator
COP00_RS17760	COG0318	PFAM AMP-dependent synthetase and ligase
COP00_RS17780	COG0789	Transcriptional regulator
COP00_RS17795	COG0697	spore germination
COP00_RS17800	COG1714	RDD family
COP00_RS17805	COG3012	SEC-C Motif Domain Protein
COP00_RS17805	COG1405	negative regulation of cell septum assembly
COP00_RS17810	COG1131	(ABC) transporter
COP00_RS17835	COG0583	DNA-binding transcription factor activity
COP00_RS17840	COG1942	4-Oxalocrotonate Tautomerase
COP00_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS17850	COG4106	trans-aconitate 2-methyltransferase activity
COP00_RS17870	COG0252	asparaginase activity
COP00_RS17875	COG0456	acetyltransferase
COP00_RS17885	COG1164	Oligoendopeptidase f
COP00_RS17890	COG2261	transglycosylase associated protein
COP00_RS17900	COG0247	lactate metabolic process
COP00_RS17905	COG0277	FAD linked oxidase domain protein
COP00_RS17910	COG3591	Belongs to the peptidase S1B family
COP00_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS17925	COG1595	DNA-templated transcription, initiation
COP00_RS17940	COG3773	Cell wall hydrolase
COP00_RS17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COP00_RS17950	COG3883	PFAM NLP P60 protein
COP00_RS17950	COG0791	NLP P60 protein
COP00_RS17960	COG1131	(ABC) transporter
COP00_RS17965	COG1309	transcriptional regulator
COP00_RS17990	COG2310	stress, protein
COP00_RS17995	COG2310	stress, protein
COP00_RS18000	COG2310	stress, protein
COP00_RS18005	COG0861	Integral membrane protein TerC family
COP00_RS18020	COG1358	cellular component organization or biogenesis
COP00_RS18040	COG3853	Toxic anion resistance protein (TelA)
COP00_RS18045	COG4175	Glycine betaine
COP00_RS18045	COG0517	IMP dehydrogenase activity
COP00_RS18050	COG4176	ABC-type proline glycine betaine transport system permease component
COP00_RS18055	COG2113	Glycine betaine
COP00_RS18060	COG1473	amidohydrolase
COP00_RS18065	COG1288	antiporter activity
COP00_RS18070	COG2223	nitrite transmembrane transporter activity
COP00_RS18075	COG0477	Major facilitator Superfamily
COP00_RS18080	COG0039	L-malate dehydrogenase activity
COP00_RS18085	COG1620	l-lactate permease
COP00_RS18090	COG1280	lysine exporter protein (LysE YggA)
COP00_RS18095	COG1113	amino acid transport
COP00_RS18100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
COP00_RS18105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COP00_RS18110	COG3541	Predicted nucleotidyltransferase
COP00_RS18115	COG0506	proline dehydrogenase activity
COP00_RS18120	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS18125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COP00_RS18130	COG2508	Transcriptional regulator
COP00_RS18135	COG3689	TIGRFAM TIGR03943 family protein
COP00_RS18140	COG0701	Predicted permease
COP00_RS18150	COG3458	cephalosporin-C deacetylase activity
COP00_RS18175	COG0765	amino acid transport
COP00_RS18180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COP00_RS18195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
COP00_RS18200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS18205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS18210	COG1120	ATPase activity
COP00_RS18215	COG3842	ATPase activity
COP00_RS18220	COG2723	6-phospho-beta-galactosidase activity
COP00_RS18240	COG5444	nuclease activity
COP00_RS18260	COG3842	ATPase activity
COP00_RS18265	COG1176	ABC-type spermidine putrescine transport system, permease component I
COP00_RS18280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COP00_RS18285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
COP00_RS18290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
COP00_RS18300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS18310	COG2819	hydrolase of the alpha beta superfamily
COP00_RS18315	COG2207	Transcriptional regulator
COP00_RS18315	COG3708	Transcriptional regulator
COP00_RS18320	COG2364	Membrane
COP00_RS18345	COG1126	abc transporter atp-binding protein
COP00_RS18350	COG0765	amino acid transport
COP00_RS18355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
COP00_RS18360	COG3829	transcription factor binding
COP00_RS18365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
COP00_RS18375	COG0010	Belongs to the arginase family
COP00_RS18380	COG2364	Membrane
COP00_RS18385	COG1846	Transcriptional regulator
COP00_RS18390	COG0456	acetyltransferase
COP00_RS18395	COG2808	Putative FMN-binding domain
COP00_RS18400	COG0583	DNA-binding transcription factor activity
COP00_RS18405	COG0163	prenyltransferase activity
COP00_RS18410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
COP00_RS18470	COG2972	Histidine kinase
COP00_RS18480	COG4213	ABC transporter substrate-binding protein
COP00_RS18490	COG4214	carbohydrate transport
COP00_RS18495	COG2271	Major facilitator Superfamily
COP00_RS18500	COG1846	Transcriptional regulator
COP00_RS18500	COG0456	acetyltransferase
COP00_RS18505	COG1874	Beta-galactosidase
COP00_RS18510	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
COP00_RS18520	COG3104	oligopeptide transport
COP00_RS18525	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS18535	COG0697	spore germination
COP00_RS18545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
COP00_RS18550	COG0789	Transcriptional regulator
COP00_RS18555	COG1136	(ABC) transporter
COP00_RS18560	COG0577	efflux transmembrane transporter activity
COP00_RS18565	COG0745	RESPONSE REGULATOR receiver
COP00_RS18575	COG0840	transmembrane signaling receptor activity
COP00_RS18575	COG5278	phosphoserine phosphatase activity
COP00_RS18580	COG0527	aspartate kinase activity
COP00_RS18585	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS18590	COG4605	iron ion homeostasis
COP00_RS18595	COG4604	ABC transporter, ATP-binding protein
COP00_RS18600	COG4607	ABC-type enterochelin transport system periplasmic component
COP00_RS18605	COG2814	Major facilitator Superfamily
COP00_RS18610	COG1309	transcriptional regulator
COP00_RS18620	COG0778	Nitroreductase
COP00_RS18625	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
COP00_RS18630	COG0640	Transcriptional regulator
COP00_RS18635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS18640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
COP00_RS18645	COG0531	amino acid
COP00_RS18650	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS18655	COG4221	oxidoreductase activity
COP00_RS18660	COG4549	nuclear export factor GLE1
COP00_RS18665	COG2372	response to copper ion
COP00_RS18665	COG1276	copper resistance
COP00_RS18670	COG1349	DNA-binding transcription factor activity
COP00_RS18675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
COP00_RS18680	COG0243	molybdopterin cofactor binding
COP00_RS18690	COG2146	nitrite reductase [NAD(P)H] activity
COP00_RS18695	COG1587	Uroporphyrinogen-III synthase
COP00_RS18695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
COP00_RS18700	COG0789	Transcriptional regulator
COP00_RS18715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COP00_RS18725	COG0561	phosphatase activity
COP00_RS18730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
COP00_RS18735	COG1914	H( )-stimulated, divalent metal cation uptake system
COP00_RS18740	COG4336	lyase activity
COP00_RS18745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
COP00_RS18750	COG1984	allophanate hydrolase subunit 2
COP00_RS18755	COG1414	Transcriptional regulator
COP00_RS18760	COG2755	lipolytic protein G-D-S-L family
COP00_RS18765	COG2213	PTS system mannitol-specific
COP00_RS18770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
COP00_RS18775	COG0246	Mannitol dehydrogenase
COP00_RS18780	COG3711	transcriptional antiterminator
COP00_RS18785	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS18790	COG1917	Cupin 2, conserved barrel domain protein
COP00_RS18795	COG3871	stress protein (general stress protein 26)
COP00_RS18810	COG2814	Major facilitator Superfamily
COP00_RS18820	COG1522	sequence-specific DNA binding
COP00_RS18825	COG0551	DNA topoisomerase type I activity
COP00_RS18825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
COP00_RS18830	COG0287	Prephenate dehydrogenase
COP00_RS18835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COP00_RS18835	COG0512	Glutamine amidotransferase of anthranilate synthase
COP00_RS18840	COG1605	Chorismate mutase
COP00_RS18855	COG0531	amino acid
COP00_RS18860	COG0028	Belongs to the TPP enzyme family
COP00_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS18880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS18885	COG1914	H( )-stimulated, divalent metal cation uptake system
COP00_RS18890	COG2261	transglycosylase associated protein
COP00_RS18900	COG1819	glycosyl
COP00_RS18905	COG4876	unkown
COP00_RS18910	COG2217	Heavy metal translocating P-type atpase
COP00_RS18925	COG0662	Cupin 2, conserved barrel domain protein
COP00_RS18935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
COP00_RS18940	COG3290	protein histidine kinase activity
COP00_RS18945	COG4565	transcriptional regulatory protein
COP00_RS18950	COG1301	dicarboxylic acid transport
COP00_RS18955	COG0628	permease
COP00_RS18965	COG1131	(ABC) transporter
COP00_RS18970	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
COP00_RS18995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COP00_RS19000	COG1181	Belongs to the D-alanine--D-alanine ligase family
COP00_RS19005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
COP00_RS19020	COG0513	Belongs to the DEAD box helicase family
COP00_RS19025	COG3402	PFAM membrane-flanked domain
COP00_RS19030	COG3428	Bacterial PH domain
COP00_RS19035	COG0705	Rhomboid family
COP00_RS19040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
COP00_RS19045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COP00_RS19050	COG0864	Transcriptional regulator
COP00_RS19055	COG2337	Toxic component of a toxin-antitoxin (TA) module
COP00_RS19060	COG1366	Belongs to the anti-sigma-factor antagonist family
COP00_RS19065	COG1366	Belongs to the anti-sigma-factor antagonist family
COP00_RS19075	COG2208	phosphoserine phosphatase activity
COP00_RS19090	COG1191	sigma factor activity
COP00_RS19095	COG2208	phosphoserine phosphatase activity
COP00_RS19100	COG2183	response to ionizing radiation
COP00_RS19110	COG3091	SprT-like family
COP00_RS19170	COG0726	polysaccharide deacetylase
COP00_RS19200	COG0457	Tetratricopeptide repeat
COP00_RS19205	COG0640	Transcriptional regulator
COP00_RS19215	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
COP00_RS19225	COG1733	regulation of RNA biosynthetic process
COP00_RS19230	COG0697	spore germination
COP00_RS19235	COG1917	Cupin 2, conserved barrel domain protein
COP00_RS19235	COG2207	Transcriptional regulator
COP00_RS19240	COG0697	spore germination
COP00_RS19245	COG2814	Major facilitator Superfamily
COP00_RS19250	COG1309	transcriptional regulator
COP00_RS19255	COG0110	maltose O-acetyltransferase activity
COP00_RS19260	COG2814	Major facilitator Superfamily
COP00_RS19270	COG1114	Component of the transport system for branched-chain amino acids
COP00_RS19275	COG3621	Patatin-like phospholipase
COP00_RS19280	COG1733	regulation of RNA biosynthetic process
COP00_RS19285	COG2249	NAD(P)H dehydrogenase (quinone) activity
COP00_RS19290	COG1113	amino acid transport
COP00_RS19295	COG1216	Glycosyl transferase, family 2
COP00_RS19305	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
COP00_RS19325	COG0778	Nitroreductase
COP00_RS19330	COG1846	Transcriptional regulator
COP00_RS19335	COG0596	Alpha beta hydrolase
COP00_RS19340	COG5566	PFAM Mor transcription activator
COP00_RS19345	COG1595	DNA-templated transcription, initiation
COP00_RS19355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
COP00_RS19355	COG2755	lipolytic protein G-D-S-L family
COP00_RS19360	COG0494	nUDIX hydrolase
COP00_RS19365	COG2814	Major facilitator Superfamily
COP00_RS19370	COG1979	alcohol dehydrogenase
COP00_RS19375	COG0745	RESPONSE REGULATOR receiver
COP00_RS19375	COG2972	Histidine kinase
COP00_RS19380	COG3279	Response regulator of the LytR AlgR family
COP00_RS19390	COG3764	Sortase (surface protein transpeptidase)
COP00_RS19395	COG2851	Citrate transporter
COP00_RS19400	COG3181	Tripartite tricarboxylate transporter family receptor
COP00_RS19415	COG2814	Major facilitator Superfamily
COP00_RS19460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
COP00_RS19465	COG0802	atpase or kinase
COP00_RS19470	COG1214	PFAM Peptidase M22, glycoprotease
COP00_RS19475	COG0456	acetyltransferase
COP00_RS19480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COP00_RS19485	COG0488	(ABC) transporter
COP00_RS19490	COG0315	cyclic pyranopterin monophosphate synthase activity
COP00_RS19500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COP00_RS19505	COG0805	protein transport
COP00_RS19515	COG1266	CAAX protease self-immunity
COP00_RS19520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COP00_RS19525	COG0459	protein refolding
COP00_RS19530	COG4974	Belongs to the 'phage' integrase family
COP00_RS19535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COP00_RS19550	COG3561	AntA/AntB antirepressor
COP00_RS19685	COG1802	Transcriptional regulator
COP00_RS19685	COG4626	Terminase
COP00_RS19700	COG0740	serine-type endopeptidase activity
COP00_RS19745	COG5280	Phage tail tape measure protein TP901
COP00_RS19745	COG3953	SLT domain
COP00_RS19755	COG1705	Flagellar rod assembly protein muramidase FlgJ
COP00_RS19760	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS19780	COG4824	toxin secretion phage lysis holin
COP00_RS19795	COG5444	nuclease activity
COP00_RS19800	COG0457	Tetratricopeptide repeat
COP00_RS19850	COG5444	nuclease activity
COP00_RS19890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COP00_RS19905	COG2323	membrane
COP00_RS19910	COG2135	peptidase activity
COP00_RS19915	COG0346	lactoylglutathione lyase activity
COP00_RS19920	COG0531	amino acid
COP00_RS19955	COG3189	MarR family transcriptional regulator
COP00_RS19960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
COP00_RS19965	COG2814	Major facilitator Superfamily
COP00_RS19980	COG1378	Sugar-specific transcriptional regulator TrmB
COP00_RS19985	COG1280	lysine exporter protein (LysE YggA)
COP00_RS19990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
COP00_RS20020	COG0726	polysaccharide deacetylase
COP00_RS20030	COG1609	Transcriptional regulator
COP00_RS20040	COG2182	Extracellular solute-binding protein
COP00_RS20045	COG1175	transmembrane transport
COP00_RS20050	COG3833	ABC-type maltose transport systems, permease component
COP00_RS20055	COG5521	maltodextrose utilization protein MalA
COP00_RS20060	COG1554	hydrolase, family 65, central catalytic
COP00_RS20065	COG0366	Alpha amylase catalytic
COP00_RS20070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
COP00_RS20095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
COP00_RS20100	COG0823	Involved in the tonB-independent uptake of proteins
COP00_RS20120	COG0702	epimerase
COP00_RS20130	COG2132	Multicopper oxidase
COP00_RS20140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
COP00_RS20145	COG0714	Associated with various cellular activities
COP00_RS20150	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
COP00_RS20155	COG1305	Transglutaminase-like
COP00_RS20160	COG0519	Catalyzes the synthesis of GMP from XMP
COP00_RS20160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
COP00_RS20165	COG2252	PERMEase
COP00_RS20175	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
COP00_RS20185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
COP00_RS20190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
COP00_RS20195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
COP00_RS20200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
COP00_RS20205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COP00_RS20210	COG0047	phosphoribosylformylglycinamidine synthase activity
COP00_RS20215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COP00_RS20220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
COP00_RS20225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
COP00_RS20230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COP00_RS20235	COG0138	bifunctional purine biosynthesis protein purh
COP00_RS20240	COG0151	Belongs to the GarS family
COP00_RS20260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
COP00_RS20265	COG1470	cell adhesion involved in biofilm formation
COP00_RS20270	COG4496	protein, YerC YecD
COP00_RS20275	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
COP00_RS20280	COG0210	DNA helicase
COP00_RS20285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COP00_RS20290	COG4851	CamS sex pheromone cAM373 precursor
COP00_RS20295	COG1285	pathogenesis
COP00_RS20305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
COP00_RS20310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COP00_RS20315	COG0154	amidase activity
COP00_RS20320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COP00_RS20330	COG1063	alcohol dehydrogenase
COP00_RS20335	COG1309	transcriptional regulator
COP00_RS20340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
COP00_RS20345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
COP00_RS20350	COG1957	nucleoside hydrolase
COP00_RS20355	COG1597	lipid kinase activity
COP00_RS20360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COP00_RS20385	COG2190	(PTS) system
COP00_RS20385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS20385	COG1263	PTS System
COP00_RS20390	COG2723	6-phospho-beta-galactosidase activity
COP00_RS20395	COG3711	transcriptional antiterminator
COP00_RS20400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
COP00_RS20405	COG0457	Tetratricopeptide repeat
COP00_RS20430	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS20435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
COP00_RS20435	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
COP00_RS20440	COG3586	endonuclease activity
COP00_RS20450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS20455	COG0697	spore germination
COP00_RS20460	COG0217	transcriptional regulatory protein
COP00_RS20470	COG0471	metal ion transport
COP00_RS20475	COG0281	malic enzyme
COP00_RS20480	COG0583	DNA-binding transcription factor activity
COP00_RS20485	COG1012	belongs to the aldehyde dehydrogenase family
COP00_RS20490	COG0840	transmembrane signaling receptor activity
COP00_RS20495	COG0109	protoheme IX farnesyltransferase activity
COP00_RS20500	COG1309	transcriptional regulator
COP00_RS20505	COG0471	metal ion transport
COP00_RS20510	COG0488	(ABC) transporter
COP00_RS20515	COG0640	Transcriptional regulator
COP00_RS20520	COG2814	Major facilitator Superfamily
COP00_RS20525	COG1469	GTP cyclohydrolase I activity
COP00_RS20545	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
COP00_RS20550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
COP00_RS20555	COG0156	8-amino-7-oxononanoate synthase activity
COP00_RS20560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
COP00_RS20565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
COP00_RS20570	COG2124	cytochrome p450
COP00_RS20575	COG0789	Transcriptional regulator
COP00_RS20580	COG2814	Major facilitator Superfamily
COP00_RS20585	COG0488	(ABC) transporter
COP00_RS20590	COG0513	Belongs to the DEAD box helicase family
COP00_RS20605	COG0471	metal ion transport
COP00_RS20615	COG1136	(ABC) transporter
COP00_RS20635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS20645	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
COP00_RS20650	COG3858	chitin binding
COP00_RS20665	COG5658	integral membrane protein
COP00_RS20670	COG0640	Transcriptional regulator
COP00_RS20675	COG1254	Belongs to the acylphosphatase family
COP00_RS20680	COG2258	MOSC domain
COP00_RS20695	COG0024	Methionine aminopeptidase
COP00_RS20700	COG1368	sulfuric ester hydrolase activity
COP00_RS20715	COG1263	PTS System
COP00_RS20715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS20720	COG0366	Alpha amylase catalytic
COP00_RS20725	COG2188	Transcriptional regulator
COP00_RS20740	COG1215	transferase activity, transferring glycosyl groups
COP00_RS20745	COG0463	Glycosyl transferase, family 2
COP00_RS20745	COG0457	Tetratricopeptide repeat
COP00_RS20750	COG0438	transferase activity, transferring glycosyl groups
COP00_RS20785	COG2076	Multidrug Resistance protein
COP00_RS20790	COG1309	transcriptional regulator
COP00_RS20795	COG0657	acetylesterase activity
COP00_RS20800	COG1733	regulation of RNA biosynthetic process
COP00_RS20805	COG0778	Nitroreductase
COP00_RS20820	COG0737	Belongs to the 5'-nucleotidase family
COP00_RS20830	COG4840	Belongs to the UPF0435 family
COP00_RS20835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
COP00_RS20845	COG1295	ribonuclease BN
COP00_RS20860	COG0387	Pfam Sodium calcium exchanger
COP00_RS20870	COG0535	radical SAM domain protein
COP00_RS20880	COG0726	polysaccharide deacetylase
COP00_RS20890	COG0371	Dehydrogenase
COP00_RS20905	COG0598	Magnesium transport protein CorA
COP00_RS20910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
COP00_RS20915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COP00_RS20920	COG4637	Psort location Cytoplasmic, score
COP00_RS20940	COG1819	glycosyl
COP00_RS20950	COG0477	Major facilitator Superfamily
COP00_RS20955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS20955	COG1263	PTS System
COP00_RS20960	COG3711	transcriptional antiterminator
COP00_RS20970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
COP00_RS20975	COG0022	dehydrogenase e1 component
COP00_RS20985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COP00_RS20990	COG3284	Transcriptional regulator
COP00_RS20995	COG1742	UPF0060 membrane protein
COP00_RS21000	COG1486	melibiose metabolic process
COP00_RS21005	COG1737	Transcriptional regulator
COP00_RS21010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
COP00_RS21010	COG1263	PTS System
COP00_RS21020	COG1733	regulation of RNA biosynthetic process
COP00_RS21025	COG2259	Doxx family
COP00_RS21030	COG2514	catechol 2,3-dioxygenase activity
COP00_RS21045	COG1917	Cupin 2, conserved barrel domain protein
COP00_RS21045	COG2207	Transcriptional regulator
COP00_RS21055	COG1309	transcriptional regulator
COP00_RS21060	COG2814	Major facilitator Superfamily
COP00_RS21065	COG2249	NAD(P)H dehydrogenase (quinone) activity
COP00_RS21070	COG1051	belongs to the nudix hydrolase family
COP00_RS21080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
COP00_RS21080	COG0392	lysyltransferase activity
COP00_RS21085	COG0384	phenazine biosynthesis protein PhzF
COP00_RS21090	COG0778	Nitroreductase
COP00_RS21115	COG2137	regulation of response to DNA damage stimulus
COP00_RS21140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
COP00_RS21145	COG0463	Glycosyl transferase, family 2
COP00_RS21155	COG4485	Bacterial membrane protein, YfhO
COP00_RS21160	COG1988	membrane-bound metal-dependent
COP00_RS21165	COG1194	a g-specific adenine glycosylase
COP00_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS21190	COG3557	Belongs to the UPF0374 family
COP00_RS21195	COG1132	(ABC) transporter
COP00_RS21200	COG0444	Belongs to the ABC transporter superfamily
COP00_RS21205	COG4608	Belongs to the ABC transporter superfamily
COP00_RS21210	COG0747	negative chemotaxis
COP00_RS21215	COG0601	transmembrane transport
COP00_RS21220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COP00_RS21225	COG4129	membrane
COP00_RS21230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
COP00_RS21235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
COP00_RS21240	COG0735	belongs to the Fur family
COP00_RS21350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COP00_RS21370	COG0710	3-dehydroquinate dehydratase activity
COP00_RS21385	COG1116	anion transmembrane transporter activity
COP00_RS21390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
COP00_RS21395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
COP00_RS21400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
COP00_RS21410	COG1476	TRANSCRIPTIONal
COP00_RS21420	COG1122	ATPase activity
COP00_RS21440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COP00_RS21450	COG3382	B3 4 domain protein
COP00_RS21455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
COP00_RS21465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
COP00_RS21470	COG0789	Transcriptional regulator
COP00_RS21475	COG1664	Polymer-forming cytoskeletal
COP00_RS21485	COG2766	serine protein kinase
COP00_RS21490	COG2718	Belongs to the UPF0229 family
COP00_RS21495	COG1566	PFAM secretion protein HlyD family protein
COP00_RS21500	COG2814	Major facilitator Superfamily
COP00_RS21505	COG0655	NAD(P)H dehydrogenase (quinone) activity
COP00_RS21520	COG1725	Transcriptional regulator
COP00_RS21525	COG1131	(ABC) transporter
COP00_RS21530	COG1131	(ABC) transporter
COP00_RS21535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
COP00_RS21540	COG1278	Cold shock
COP00_RS21545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
COP00_RS21550	COG2011	ABC-type metal ion transport system permease component
COP00_RS21555	COG1464	Belongs to the NlpA lipoprotein family
COP00_RS21560	COG1823	symporter activity
COP00_RS21585	COG5577	PFAM Coat F domain
COP00_RS21590	COG5002	protein histidine kinase activity
COP00_RS21595	COG0737	Belongs to the 5'-nucleotidase family
COP00_RS21595	COG4085	toxin activity
COP00_RS21595	COG1525	nuclease
COP00_RS21600	COG3764	Sortase (surface protein transpeptidase)
COP00_RS21605	COG1125	glycine betaine transport
COP00_RS21605	COG0517	IMP dehydrogenase activity
COP00_RS21610	COG1174	glycine betaine transport
COP00_RS21615	COG1732	Glycine betaine
COP00_RS21620	COG1174	glycine betaine transport
COP00_RS21625	COG0564	pseudouridine synthase activity
COP00_RS21635	COG0517	IMP dehydrogenase activity
COP00_RS21640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
COP00_RS21645	COG3153	acetyltransferase
COP00_RS21645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
COP00_RS21650	COG0488	(ABC) transporter
COP00_RS21665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
COP00_RS21670	COG0604	alcohol dehydrogenase
COP00_RS21675	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
COP00_RS21680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
COP00_RS21685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
COP00_RS21690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
COP00_RS21695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COP00_RS21725	COG0431	NADPH-dependent FMN reductase
COP00_RS21740	COG1959	2 iron, 2 sulfur cluster binding
COP00_RS21745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
COP00_RS21745	COG1017	nitric oxide dioxygenase activity
COP00_RS21750	COG2719	SpoVR family
COP00_RS21755	COG1785	Belongs to the alkaline phosphatase family
COP00_RS21765	COG1388	LysM domain
COP00_RS21765	COG0791	NLP P60 protein
COP00_RS21770	COG0583	DNA-binding transcription factor activity
COP00_RS21775	COG0372	Belongs to the citrate synthase family
COP00_RS21785	COG1846	Transcriptional regulator
COP00_RS21790	COG0531	amino acid
COP00_RS21795	COG0733	neurotransmitter:sodium symporter activity
COP00_RS21805	COG2207	Transcriptional regulator
COP00_RS21805	COG3708	Transcriptional regulator
COP00_RS21810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS21830	COG1595	DNA-templated transcription, initiation
COP00_RS21835	COG0204	Acyl-transferase
COP00_RS21850	COG1253	flavin adenine dinucleotide binding
COP00_RS21855	COG0789	Transcriptional regulator
COP00_RS21860	COG1253	flavin adenine dinucleotide binding
COP00_RS21880	COG3739	integral membrane protein
COP00_RS21885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COP00_RS21890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COP00_RS21895	COG0584	glycerophosphoryl diester phosphodiesterase
COP00_RS21905	COG0668	transmembrane transport
COP00_RS21910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
COP00_RS21920	COG0454	-acetyltransferase
COP00_RS21925	COG0726	polysaccharide deacetylase
COP00_RS21935	COG1757	Na H antiporter
COP00_RS21940	COG2017	converts alpha-aldose to the beta-anomer
COP00_RS21965	COG0589	response to stress
COP00_RS21975	COG1132	(ABC) transporter
COP00_RS21980	COG1132	(ABC) transporter
COP00_RS21985	COG0702	epimerase
COP00_RS22000	COG3842	ATPase activity
COP00_RS22005	COG2508	Transcriptional regulator
COP00_RS22020	COG0189	ligase activity
COP00_RS22025	COG4399	Belongs to the UPF0754 family
COP00_RS22030	COG3679	Belongs to the UPF0342 family
COP00_RS22035	COG0561	phosphatase activity
COP00_RS22040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
COP00_RS22050	COG0475	glutathione-regulated potassium exporter activity
COP00_RS22055	COG0490	domain, Protein
COP00_RS22065	COG1024	Enoyl-CoA hydratase
COP00_RS22080	COG4152	abc transporter atp-binding protein
COP00_RS22085	COG1668	transmembrane transport
COP00_RS22090	COG0420	3'-5' exonuclease activity
COP00_RS22095	COG4717	serine-type aminopeptidase activity
COP00_RS22100	COG3481	metal-dependent phosphohydrolase, HD sub domain
COP00_RS22110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COP00_RS22140	COG1846	Transcriptional regulator
COP00_RS22145	COG4980	gas vesicle protein
COP00_RS22160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
COP00_RS22165	COG0537	adenosine 5'-monophosphoramidase activity
COP00_RS22175	COG1131	(ABC) transporter
COP00_RS22180	COG4473	ABC transporter
COP00_RS22190	COG1473	amidohydrolase
COP00_RS22200	COG2329	Antibiotic biosynthesis monooxygenase
COP00_RS22205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
COP00_RS22210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
COP00_RS22215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
COP00_RS22220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
COP00_RS22225	COG1309	transcriptional regulator
COP00_RS22230	COG1511	domain protein
COP00_RS22235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COP00_RS22240	COG1363	Peptidase, m42
COP00_RS22245	COG1301	dicarboxylic acid transport
COP00_RS22255	COG1234	tRNA 3'-trailer cleavage
COP00_RS22260	COG0095	Lipoate-protein ligase
COP00_RS22265	COG0318	PFAM AMP-dependent synthetase and ligase
COP00_RS22275	COG1396	sequence-specific DNA binding
COP00_RS22290	COG0501	Belongs to the peptidase M48B family
COP00_RS22305	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
COP00_RS22310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS22315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
COP00_RS22320	COG0406	alpha-ribazole phosphatase activity
COP00_RS22325	COG0840	transmembrane signaling receptor activity
COP00_RS22330	COG0723	plastoquinol--plastocyanin reductase activity
COP00_RS22330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
COP00_RS22335	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS22345	COG4903	ComK protein
COP00_RS22360	COG0398	Pfam SNARE associated Golgi protein
COP00_RS22365	COG0681	Belongs to the peptidase S26 family
COP00_RS22370	COG1404	Belongs to the peptidase S8 family
COP00_RS22375	COG0457	Tetratricopeptide repeat
COP00_RS22380	COG1609	Transcriptional regulator
COP00_RS22385	COG1653	transport
COP00_RS22390	COG1175	transmembrane transport
COP00_RS22395	COG0395	ABC-type sugar transport system, permease component
COP00_RS22400	COG1486	melibiose metabolic process
COP00_RS22405	COG3180	Ammonia monooxygenase
COP00_RS22420	COG3546	catalase activity
COP00_RS22425	COG0318	PFAM AMP-dependent synthetase and ligase
COP00_RS22435	COG2720	vancomycin resistance protein
COP00_RS22440	COG5002	protein histidine kinase activity
COP00_RS22450	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
COP00_RS22455	COG0725	ABC transporter, periplasmic molybdate-binding protein
COP00_RS22460	COG4149	molybdate abc transporter
COP00_RS22465	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
COP00_RS22470	COG1074	ATP-dependent DNA helicase activity
COP00_RS22475	COG0420	3'-5' exonuclease activity
COP00_RS22480	COG0419	ATPase involved in DNA repair
COP00_RS22535	COG0179	Fumarylacetoacetate (FAA) hydrolase
COP00_RS22555	COG0367	asparagine synthase
COP00_RS22560	COG0534	Mate efflux family protein
COP00_RS22565	COG2207	Transcriptional regulator
COP00_RS22565	COG1917	Cupin 2, conserved barrel domain protein
COP00_RS22595	COG0697	spore germination
COP00_RS22605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
COP00_RS22615	COG0076	glutamate decarboxylase activity
COP00_RS22640	COG2153	protein acetylation
COP00_RS22645	COG0646	methionine synthase
COP00_RS22645	COG1410	methionine synthase
COP00_RS22650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
COP00_RS22650	COG0646	methionine synthase
COP00_RS22655	COG1666	GTP binding
COP00_RS22660	COG2996	Protein conserved in bacteria
COP00_RS22675	COG1307	EDD domain protein, DegV family
COP00_RS22680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
COP00_RS22690	COG0516	GMP reductase activity
COP00_RS22700	COG0561	phosphatase activity
COP00_RS22705	COG1073	alpha beta
COP00_RS22710	COG2151	metal-sulfur cluster biosynthetic enzyme
COP00_RS22720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
COP00_RS22725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
COP00_RS22730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
COP00_RS22735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
COP00_RS22740	COG0505	Belongs to the CarA family
COP00_RS22745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
COP00_RS22750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COP00_RS22765	COG2267	carboxylic ester hydrolase activity
COP00_RS22775	COG1744	ABC transporter substrate-binding protein PnrA-like
COP00_RS22790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COP00_RS22795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
COP00_RS22800	COG5504	Zn-dependent protease
COP00_RS22805	COG0444	Belongs to the ABC transporter superfamily
COP00_RS22810	COG4608	Belongs to the ABC transporter superfamily
COP00_RS22820	COG0601	transmembrane transport
COP00_RS22825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COP00_RS22835	COG0180	Tryptophanyl-tRNA synthetase
COP00_RS22845	COG4166	transmembrane transport
COP00_RS22850	COG0601	transmembrane transport
COP00_RS22855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COP00_RS22860	COG0444	Belongs to the ABC transporter superfamily
COP00_RS22865	COG4608	Belongs to the ABC transporter superfamily
COP00_RS22870	COG0456	acetyltransferase
COP00_RS22875	COG1393	Belongs to the ArsC family
COP00_RS22880	COG0861	Integral membrane protein TerC family
COP00_RS22885	COG4862	establishment of competence for transformation
COP00_RS22890	COG4469	Competence protein
COP00_RS22895	COG1164	Oligoendopeptidase f
COP00_RS22910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
COP00_RS22915	COG2346	COG2346, Truncated hemoglobins
COP00_RS22920	COG0741	lytic transglycosylase activity
COP00_RS22925	COG4116	CYTH
COP00_RS22935	COG2357	RelA SpoT domain protein
COP00_RS22940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COP00_RS22945	COG0564	pseudouridine synthase activity
COP00_RS22950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
COP00_RS22955	COG0569	domain protein
COP00_RS22955	COG0475	glutathione-regulated potassium exporter activity
COP00_RS22960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
COP00_RS22965	COG0352	thiamine-phosphate diphosphorylase activity
COP00_RS22975	COG2104	thiamine diphosphate biosynthetic process
COP00_RS22985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
COP00_RS22990	COG0351	phosphomethylpyrimidine kinase
COP00_RS22995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
COP00_RS23050	COG0210	DNA helicase
COP00_RS23060	COG0586	Pfam SNARE associated Golgi protein
COP00_RS23065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
COP00_RS23075	COG2246	polysaccharide biosynthetic process
COP00_RS23080	COG2153	protein acetylation
COP00_RS23085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
COP00_RS23090	COG2382	esterase
COP00_RS23095	COG0626	cystathionine gamma-synthase activity
COP00_RS23100	COG0626	cystathionine gamma-synthase activity
COP00_RS23125	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
COP00_RS23135	COG3591	Belongs to the peptidase S1B family
COP00_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS23165	COG0346	lactoylglutathione lyase activity
COP00_RS23185	COG2267	carboxylic ester hydrolase activity
COP00_RS23205	COG0531	amino acid
COP00_RS23210	COG0583	DNA-binding transcription factor activity
COP00_RS23215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
COP00_RS23220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
COP00_RS23230	COG0583	DNA-binding transcription factor activity
COP00_RS23240	COG0346	lactoylglutathione lyase activity
COP00_RS23250	COG1388	LysM domain
COP00_RS23250	COG3584	3D domain protein
COP00_RS23260	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS23265	COG2814	Major facilitator Superfamily
COP00_RS23270	COG1309	transcriptional regulator
COP00_RS23420	COG1802	Transcriptional regulator
COP00_RS23420	COG4626	Terminase
COP00_RS23490	COG1705	Flagellar rod assembly protein muramidase FlgJ
COP00_RS23495	COG5434	Belongs to the glycosyl hydrolase 28 family
COP00_RS23515	COG4824	toxin secretion phage lysis holin
COP00_RS23530	COG5444	nuclease activity
COP00_RS23535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
COP00_RS23580	COG5444	nuclease activity
COP00_RS23595	COG4195	phage-related replication protein
COP00_RS23600	COG2856	Zn peptidase
COP00_RS23605	COG1396	sequence-specific DNA binding
COP00_RS23620	COG1522	sequence-specific DNA binding
COP00_RS23625	COG1484	DNA-dependent DNA replication
COP00_RS23640	COG1595	DNA-templated transcription, initiation
COP00_RS23650	COG0584	glycerophosphoryl diester phosphodiesterase
COP00_RS23660	COG1802	Transcriptional regulator
COP00_RS23665	COG1063	alcohol dehydrogenase
COP00_RS23670	COG1312	Catalyzes the dehydration of D-mannonate
COP00_RS23675	COG1028	Short-chain dehydrogenase reductase Sdr
COP00_RS23690	COG2271	Major facilitator Superfamily
COP00_RS23705	COG0306	phosphate transporter
COP00_RS23710	COG1392	Phosphate transport regulator
COP00_RS23715	COG0405	Gamma-glutamyltransferase
COP00_RS23720	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
COP00_RS23730	COG4208	sulfate ABC transporter
COP00_RS23740	COG5578	integral membrane protein
COP00_RS23745	COG2972	Histidine kinase
COP00_RS23750	COG2207	Transcriptional regulator
COP00_RS23750	COG4753	response regulator
COP00_RS23765	COG0395	ABC-type sugar transport system, permease component
COP00_RS23770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
COP00_RS23775	COG2207	Transcriptional regulator
COP00_RS23780	COG2755	lipolytic protein G-D-S-L family
COP00_RS23790	COG5578	integral membrane protein
COP00_RS23795	COG3401	FG-GAP repeat protein
COP00_RS23800	COG3401	FG-GAP repeat protein
COP00_RS23805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COP00_RS23810	COG2755	lipolytic protein G-D-S-L family
COP00_RS23815	COG1874	Beta-galactosidase
COP00_RS23825	COG1653	transport
COP00_RS23830	COG4209	transmembrane transport
COP00_RS23835	COG0395	ABC-type sugar transport system, permease component
COP00_RS23840	COG0531	amino acid
COP00_RS23845	COG0346	lactoylglutathione lyase activity
COP00_RS23850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
COP00_RS23855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
COP00_RS23860	COG2362	D-Aminopeptidase
COP00_RS23865	COG0601	transmembrane transport
COP00_RS23870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
COP00_RS23875	COG0444	Belongs to the ABC transporter superfamily
COP00_RS23885	COG1619	proteins homologs of microcin C7 resistance protein MccF
COP00_RS23890	COG4948	Mandelate Racemase Muconate Lactonizing
COP00_RS23895	COG0791	NLP P60 protein
COP00_RS23900	COG4608	Belongs to the ABC transporter superfamily
COP00_RS23910	COG1834	amidinotransferase
COP00_RS23915	COG1607	acyl-coa hydrolase
COP00_RS23920	COG3866	Pectate lyase
COP00_RS23925	COG2318	DinB family
COP00_RS23930	COG2076	Multidrug Resistance protein
COP00_RS23935	COG2076	Multidrug Resistance protein
COP00_RS23940	COG0788	formyltetrahydrofolate deformylase activity
COP00_RS23945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COP00_RS23950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COP00_RS23955	COG1764	response to oxidative stress
COP00_RS23960	COG1846	Transcriptional regulator
COP00_RS23965	COG1764	response to oxidative stress
COP00_RS23975	COG0590	tRNA wobble adenosine to inosine editing
COP00_RS23995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
COP00_RS24000	COG1404	Belongs to the peptidase S8 family
COP00_RS24005	COG2239	Acts as a magnesium transporter
COP00_RS24015	COG0789	Transcriptional regulator
COP00_RS24030	COG1846	Transcriptional regulator
COP00_RS24035	COG3285	dna ligase
COP00_RS24035	COG1793	dna ligase
COP00_RS24040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
COP00_RS24050	COG0586	Pfam SNARE associated Golgi protein
COP00_RS24055	COG0861	Integral membrane protein TerC family
COP00_RS24060	COG1191	sigma factor activity
COP00_RS24080	COG0501	Belongs to the peptidase M48B family
COP00_RS24085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
COP00_RS24090	COG0768	penicillin binding
COP00_RS24105	COG3594	Acyltransferase
COP00_RS24110	COG5002	protein histidine kinase activity
COP00_RS24115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
COP00_RS24120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
COP00_RS24125	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
COP00_RS24130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
COP00_RS24135	COG0436	Aminotransferase
COP00_RS24140	COG1850	ribulose-bisphosphate carboxylase activity
COP00_RS24150	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
COP00_RS24155	COG0346	lactoylglutathione lyase activity
COP00_RS24160	COG3339	Conserved Protein
COP00_RS24170	COG3852	Histidine kinase
COP00_RS24175	COG1846	Transcriptional regulator
COP00_RS24180	COG1360	Flagellar Motor Protein
COP00_RS24185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
COP00_RS24190	COG0542	response to heat
COP00_RS24195	COG3949	Membrane
COP00_RS24200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
COP00_RS24205	COG0720	synthase
COP00_RS24210	COG0602	queuosine metabolic process
COP00_RS24215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
COP00_RS24275	COG3617	BRO family, N-terminal domain
COP00_RS24335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS24335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
COP00_RS24345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
COP00_RS24370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS24380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COP00_RS24390	COG0756	dUTP diphosphatase activity
COP00_RS24400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
COP00_RS24405	COG3584	3D domain protein
COP00_RS24520	COG0740	serine-type endopeptidase activity