locus-tag	class	description
BH_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BH_RS00020	COG0592	DNA-directed DNA polymerase activity
BH_RS00025	COG2501	S4 domain
BH_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BH_RS00040	COG0187	DNA topoisomerase II activity
BH_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BH_RS00125	COG0516	GMP reductase activity
BH_RS00125	COG0517	IMP dehydrogenase activity
BH_RS00135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BH_RS00140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BH_RS00145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BH_RS00155	COG0737	Belongs to the 5'-nucleotidase family
BH_RS00160	COG4608	Belongs to the ABC transporter superfamily
BH_RS00165	COG0444	Belongs to the ABC transporter superfamily
BH_RS00170	COG0601	transmembrane transport
BH_RS00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS00180	COG0747	negative chemotaxis
BH_RS00190	COG0590	tRNA wobble adenosine to inosine editing
BH_RS00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BH_RS00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BH_RS00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BH_RS00235	COG3344	reverse transcriptase
BH_RS00245	COG1982	Orn Lys Arg decarboxylase major
BH_RS00250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BH_RS00255	COG3870	Protein conserved in bacteria
BH_RS00260	COG0470	DNA polymerase III
BH_RS00265	COG1774	PSP1 C-terminal conserved region
BH_RS00270	COG4467	Involved in initiation control of chromosome replication
BH_RS00275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BH_RS00280	COG2827	Endonuclease containing a URI domain
BH_RS00285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BH_RS00290	COG2002	toxin-antitoxin pair type II binding
BH_RS00305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BH_RS00305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BH_RS00310	COG0084	hydrolase, TatD family'
BH_RS00315	COG3583	domain protein
BH_RS00315	COG3584	3D domain protein
BH_RS00325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BH_RS00335	COG4466	Protein conserved in bacteria
BH_RS00345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BH_RS00350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BH_RS00355	COG0251	oxidation-reduction process
BH_RS00360	COG2088	sporulation resulting in formation of a cellular spore
BH_RS00365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BH_RS00370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BH_RS00375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BH_RS00380	COG0193	aminoacyl-tRNA hydrolase activity
BH_RS00390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BH_RS00395	COG2002	toxin-antitoxin pair type II binding
BH_RS00400	COG2244	polysaccharide biosynthetic process
BH_RS00405	COG3956	TIGRFAM MazG family protein
BH_RS00410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BH_RS00430	COG1098	S1 RNA binding domain
BH_RS00440	COG2208	phosphoserine phosphatase activity
BH_RS00445	COG2304	oxidoreductase activity
BH_RS00450	COG0515	serine threonine protein kinase
BH_RS00455	COG2966	Psort location CytoplasmicMembrane, score
BH_RS00465	COG0037	tRNA processing
BH_RS00470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BH_RS00475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BH_RS00480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BH_RS00485	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BH_RS00490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BH_RS00500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BH_RS00505	COG0512	Glutamine amidotransferase of anthranilate synthase
BH_RS00510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BH_RS00515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BH_RS00520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BH_RS00525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BH_RS00530	COG1396	sequence-specific DNA binding
BH_RS00535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BH_RS00540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BH_RS00630	COG3344	reverse transcriptase
BH_RS00640	COG3880	PFAM UvrB UvrC protein
BH_RS00645	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BH_RS00650	COG0542	response to heat
BH_RS00655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BH_RS00660	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BH_RS00665	COG4956	integral membrane protein (PIN domain superfamily)
BH_RS00670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BH_RS00675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BH_RS00680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BH_RS00685	COG1045	serine acetyltransferase
BH_RS00690	COG0215	cysteine-tRNA ligase activity
BH_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BH_RS00705	COG3688	RNA-binding protein containing a PIN domain
BH_RS00715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BH_RS00720	COG0250	Participates in transcription elongation, termination and antitermination
BH_RS00725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BH_RS00730	COG0081	regulation of translation
BH_RS00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BH_RS00740	COG0222	ribosome binding
BH_RS00750	COG2813	Specifically methylates the guanine in position
BH_RS00755	COG0085	RNA polymerase activity
BH_RS00760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BH_RS00765	COG1358	cellular component organization or biogenesis
BH_RS00770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BH_RS00775	COG0049	tRNA binding
BH_RS00780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BH_RS00785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BH_RS00790	COG0051	transcription antitermination factor activity, RNA binding
BH_RS00795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BH_RS00800	COG0088	Forms part of the polypeptide exit tunnel
BH_RS00805	COG0089	rRNA binding
BH_RS00810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BH_RS00815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BH_RS00820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BH_RS00825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BH_RS00830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BH_RS00835	COG0255	Belongs to the universal ribosomal protein uL29 family
BH_RS00840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BH_RS00845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BH_RS00850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BH_RS00855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BH_RS00860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BH_RS00865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BH_RS00870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BH_RS00875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BH_RS00880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BH_RS00885	COG1841	ribosomal large subunit assembly
BH_RS00890	COG0200	Binds to the 23S rRNA
BH_RS00895	COG0201	protein transport
BH_RS00900	COG0563	adenylate kinase activity
BH_RS00905	COG0024	Methionine aminopeptidase
BH_RS00915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BH_RS00920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BH_RS00925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BH_RS00930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BH_RS00935	COG0202	RNA polymerase activity
BH_RS00940	COG0203	ribosomal protein L17
BH_RS00945	COG1122	ATPase activity
BH_RS00950	COG1122	ATPase activity
BH_RS00955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BH_RS00960	COG0101	tRNA pseudouridine synthase activity
BH_RS00965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BH_RS00970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BH_RS00975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BH_RS00980	COG0765	amino acid transport
BH_RS00985	COG1126	abc transporter atp-binding protein
BH_RS01030	COG1131	(ABC) transporter
BH_RS01050	COG1486	melibiose metabolic process
BH_RS01075	COG1063	alcohol dehydrogenase
BH_RS01085	COG1063	alcohol dehydrogenase
BH_RS01090	COG3775	system Galactitol-specific IIC component
BH_RS01095	COG3414	Phosphotransferase system galactitol-specific IIB component
BH_RS01110	COG3327	negative regulation of DNA-templated transcription, initiation
BH_RS01120	COG3396	Phenylacetate-CoA oxygenase
BH_RS01135	COG2151	metal-sulfur cluster biosynthetic enzyme
BH_RS01145	COG1024	Enoyl-CoA hydratase
BH_RS01150	COG1024	Enoyl-CoA hydratase
BH_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS01160	COG1250	3-hydroxyacyl-CoA dehydrogenase
BH_RS01175	COG1024	Enoyl-CoA hydratase
BH_RS01180	COG0659	secondary active sulfate transmembrane transporter activity
BH_RS01200	COG1522	sequence-specific DNA binding
BH_RS01225	COG0733	neurotransmitter:sodium symporter activity
BH_RS01235	COG1620	l-lactate permease
BH_RS01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BH_RS01260	COG3344	reverse transcriptase
BH_RS01270	COG1402	creatininase
BH_RS01275	COG4821	SIS domain
BH_RS01285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BH_RS01295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BH_RS01300	COG2223	nitrite transmembrane transporter activity
BH_RS01325	COG2814	Major facilitator Superfamily
BH_RS01335	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS01340	COG0489	protein tyrosine kinase activity
BH_RS01350	COG2194	sulfuric ester hydrolase activity
BH_RS01355	COG0726	polysaccharide deacetylase
BH_RS01425	COG0831	urea catabolic process
BH_RS01430	COG0832	Belongs to the urease beta subunit family
BH_RS01435	COG0804	urea catabolic process
BH_RS01440	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BH_RS01450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BH_RS01455	COG0829	nickel cation binding
BH_RS01515	COG1595	DNA-templated transcription, initiation
BH_RS01520	COG5662	AntiSigma factor
BH_RS01525	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BH_RS01535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BH_RS01540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BH_RS01555	COG0745	RESPONSE REGULATOR receiver
BH_RS01560	COG2205	protein histidine kinase activity
BH_RS01565	COG1136	(ABC) transporter
BH_RS01570	COG0577	efflux transmembrane transporter activity
BH_RS01590	COG2318	DinB family
BH_RS01620	COG0384	phenazine biosynthesis protein PhzF
BH_RS01625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BH_RS01635	COG1136	(ABC) transporter
BH_RS01640	COG0577	efflux transmembrane transporter activity
BH_RS01645	COG0745	RESPONSE REGULATOR receiver
BH_RS01650	COG2205	protein histidine kinase activity
BH_RS01660	COG1131	(ABC) transporter
BH_RS01665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BH_RS01690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS01690	COG1263	PTS System
BH_RS01690	COG2190	(PTS) system
BH_RS01695	COG3711	transcriptional antiterminator
BH_RS01730	COG1959	2 iron, 2 sulfur cluster binding
BH_RS01755	COG3328	transposase activity
BH_RS01775	COG3842	ATPase activity
BH_RS01800	COG0572	uridine kinase
BH_RS01880	COG2801	Transposase and inactivated derivatives
BH_RS01910	COG1518	maintenance of DNA repeat elements
BH_RS01915	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BH_RS01940	COG0601	transmembrane transport
BH_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS01950	COG0444	Belongs to the ABC transporter superfamily
BH_RS01955	COG4608	Belongs to the ABC transporter superfamily
BH_RS01965	COG1309	transcriptional regulator
BH_RS01980	COG3328	transposase activity
BH_RS01990	COG2031	fatty acid transporter
BH_RS02020	COG1476	TRANSCRIPTIONal
BH_RS02035	COG0523	cobalamin synthesis protein
BH_RS02045	COG0717	Belongs to the dCTP deaminase family
BH_RS02050	COG0822	iron-sulfur transferase activity
BH_RS02065	COG0745	RESPONSE REGULATOR receiver
BH_RS02070	COG5002	protein histidine kinase activity
BH_RS02070	COG3850	Histidine kinase
BH_RS02080	COG3212	peptidase
BH_RS02115	COG3173	Aminoglycoside phosphotransferase
BH_RS02120	COG1131	(ABC) transporter
BH_RS02125	COG1725	Transcriptional regulator
BH_RS02140	COG3328	transposase activity
BH_RS02155	COG0697	spore germination
BH_RS02160	COG0640	Transcriptional regulator
BH_RS02165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BH_RS02170	COG2169	Transcriptional regulator
BH_RS02185	COG3290	protein histidine kinase activity
BH_RS02190	COG4565	transcriptional regulatory protein
BH_RS02195	COG0281	malic enzyme
BH_RS02225	COG0778	Nitroreductase
BH_RS02240	COG0789	Transcriptional regulator
BH_RS02245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BH_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS02260	COG2808	Putative FMN-binding domain
BH_RS02265	COG0366	Alpha amylase catalytic
BH_RS02270	COG0659	secondary active sulfate transmembrane transporter activity
BH_RS02290	COG2226	methyltransferase
BH_RS02295	COG2188	Transcriptional regulator
BH_RS02300	COG0363	glucosamine-6-phosphate deaminase activity
BH_RS02305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BH_RS02310	COG1263	PTS System
BH_RS02310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS02315	COG1522	sequence-specific DNA binding
BH_RS02340	COG1309	transcriptional regulator
BH_RS02345	COG1280	lysine exporter protein (LysE YggA)
BH_RS02355	COG1279	arginine transmembrane transporter activity
BH_RS02360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BH_RS02370	COG1011	Hydrolase
BH_RS02395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BH_RS02405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BH_RS02410	COG3639	organic phosphonate transmembrane transporter activity
BH_RS02415	COG3639	organic phosphonate transmembrane transporter activity
BH_RS02420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BH_RS02510	COG0628	permease
BH_RS02515	COG1968	undecaprenyl-diphosphatase activity
BH_RS02530	COG0569	domain protein
BH_RS02540	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BH_RS02545	COG3639	organic phosphonate transmembrane transporter activity
BH_RS02600	COG0395	ABC-type sugar transport system, permease component
BH_RS02605	COG1653	transport
BH_RS02610	COG2207	Transcriptional regulator
BH_RS02615	COG4209	transmembrane transport
BH_RS02620	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BH_RS02625	COG1653	transport
BH_RS02630	COG0673	inositol 2-dehydrogenase activity
BH_RS02635	COG5578	integral membrane protein
BH_RS02640	COG0385	Bile acid
BH_RS02645	COG2721	sulfolactate sulfo-lyase activity
BH_RS02655	COG0246	Mannitol dehydrogenase
BH_RS02680	COG0561	phosphatase activity
BH_RS02690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BH_RS02695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BH_RS02700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BH_RS02715	COG0840	transmembrane signaling receptor activity
BH_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS02730	COG1733	regulation of RNA biosynthetic process
BH_RS02740	COG2239	Acts as a magnesium transporter
BH_RS02745	COG3842	ATPase activity
BH_RS02750	COG1840	ABC-type Fe3 transport system, periplasmic component
BH_RS02755	COG1178	ABC-type Fe3 transport system permease component
BH_RS02765	COG0803	Belongs to the bacterial solute-binding protein 9 family
BH_RS02770	COG0705	Rhomboid family
BH_RS02775	COG0736	holo-[acyl-carrier-protein] synthase activity
BH_RS02780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BH_RS02785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BH_RS02790	COG0864	Transcriptional regulator
BH_RS02795	COG2337	Toxic component of a toxin-antitoxin (TA) module
BH_RS02800	COG1366	Belongs to the anti-sigma-factor antagonist family
BH_RS02805	COG1366	Belongs to the anti-sigma-factor antagonist family
BH_RS02810	COG2172	sigma factor antagonist activity
BH_RS02815	COG2208	phosphoserine phosphatase activity
BH_RS02820	COG1366	Belongs to the anti-sigma-factor antagonist family
BH_RS02825	COG2172	sigma factor antagonist activity
BH_RS02830	COG1191	sigma factor activity
BH_RS02840	COG2183	response to ionizing radiation
BH_RS02845	COG3091	SprT-like family
BH_RS02925	COG3344	reverse transcriptase
BH_RS02940	COG5002	protein histidine kinase activity
BH_RS02945	COG2204	response regulator
BH_RS02955	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS02960	COG1285	pathogenesis
BH_RS02965	COG0626	cystathionine gamma-synthase activity
BH_RS02980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BH_RS02985	COG0802	atpase or kinase
BH_RS02990	COG1214	PFAM Peptidase M22, glycoprotease
BH_RS02995	COG0456	acetyltransferase
BH_RS03000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BH_RS03010	COG0488	(ABC) transporter
BH_RS03015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BH_RS03020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BH_RS03025	COG0805	protein transport
BH_RS03030	COG2814	Major facilitator Superfamily
BH_RS03035	COG1929	Belongs to the glycerate kinase type-1 family
BH_RS03045	COG2217	Heavy metal translocating P-type atpase
BH_RS03050	COG1937	Protein conserved in bacteria
BH_RS03060	COG1266	CAAX protease self-immunity
BH_RS03070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BH_RS03075	COG0459	protein refolding
BH_RS03100	COG0747	negative chemotaxis
BH_RS03105	COG0601	transmembrane transport
BH_RS03110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS03115	COG4172	Belongs to the ABC transporter superfamily
BH_RS03120	COG4608	Belongs to the ABC transporter superfamily
BH_RS03135	COG1695	Transcriptional regulator
BH_RS03145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BH_RS03150	COG2124	cytochrome p450
BH_RS03155	COG1309	transcriptional regulator
BH_RS03160	COG2197	response regulator
BH_RS03165	COG4585	Histidine kinase
BH_RS03175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BH_RS03180	COG2188	Transcriptional regulator
BH_RS03200	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BH_RS03205	COG0626	cystathionine gamma-synthase activity
BH_RS03210	COG3457	Alanine racemase
BH_RS03215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BH_RS03225	COG2207	Transcriptional regulator
BH_RS03225	COG3708	Transcriptional regulator
BH_RS03230	COG1263	PTS System
BH_RS03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS03230	COG2190	(PTS) system
BH_RS03235	COG2723	6-phospho-beta-galactosidase activity
BH_RS03240	COG0569	domain protein
BH_RS03245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BH_RS03250	COG1136	(ABC) transporter
BH_RS03275	COG0714	Associated with various cellular activities
BH_RS03280	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BH_RS03285	COG1305	Transglutaminase-like
BH_RS03290	COG0519	Catalyzes the synthesis of GMP from XMP
BH_RS03290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BH_RS03295	COG2252	PERMEase
BH_RS03300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BH_RS03305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BH_RS03340	COG3344	reverse transcriptase
BH_RS03345	COG2223	nitrite transmembrane transporter activity
BH_RS03350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BH_RS03355	COG2146	nitrite reductase [NAD(P)H] activity
BH_RS03360	COG0243	molybdopterin cofactor binding
BH_RS03365	COG2258	MOSC domain
BH_RS03370	COG3424	synthase
BH_RS03375	COG1755	Isoprenylcysteine carboxyl methyltransferase
BH_RS03385	COG1595	DNA-templated transcription, initiation
BH_RS03390	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BH_RS03400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BH_RS03405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BH_RS03410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BH_RS03415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BH_RS03420	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BH_RS03425	COG0047	phosphoribosylformylglycinamidine synthase activity
BH_RS03430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BH_RS03435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BH_RS03440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BH_RS03445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BH_RS03450	COG0138	bifunctional purine biosynthesis protein purh
BH_RS03455	COG0151	Belongs to the GarS family
BH_RS03465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BH_RS03470	COG1470	cell adhesion involved in biofilm formation
BH_RS03475	COG4496	protein, YerC YecD
BH_RS03480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BH_RS03495	COG0393	Putative heavy-metal-binding
BH_RS03510	COG1078	dGTPase activity
BH_RS03515	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BH_RS03520	COG0210	DNA helicase
BH_RS03525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BH_RS03530	COG4851	CamS sex pheromone cAM373 precursor
BH_RS03555	COG1733	regulation of RNA biosynthetic process
BH_RS03570	COG2226	methyltransferase
BH_RS03585	COG0457	Tetratricopeptide repeat
BH_RS03590	COG0038	chloride channel
BH_RS03595	COG2323	membrane
BH_RS03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BH_RS03605	COG0154	amidase activity
BH_RS03610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BH_RS03625	COG3708	Transcriptional regulator
BH_RS03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS03640	COG1263	PTS System
BH_RS03645	COG3876	Protein conserved in bacteria
BH_RS03650	COG1472	Belongs to the glycosyl hydrolase 3 family
BH_RS03655	COG1597	lipid kinase activity
BH_RS03680	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS03690	COG0095	Lipoate-protein ligase
BH_RS03695	COG1404	Belongs to the peptidase S8 family
BH_RS03700	COG2076	Multidrug Resistance protein
BH_RS03705	COG2076	Multidrug Resistance protein
BH_RS03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BH_RS03720	COG2801	Transposase and inactivated derivatives
BH_RS03725	COG3328	transposase activity
BH_RS03740	COG1388	LysM domain
BH_RS03740	COG3942	CHAP domain
BH_RS03745	COG0640	Transcriptional regulator
BH_RS03760	COG3340	Belongs to the peptidase S51 family
BH_RS03785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BH_RS03800	COG1904	glucuronate isomerase
BH_RS03805	COG1312	Catalyzes the dehydration of D-mannonate
BH_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS03835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BH_RS03840	COG1132	(ABC) transporter
BH_RS03845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BH_RS03875	COG2409	Drug exporters of the RND superfamily
BH_RS03895	COG2207	Transcriptional regulator
BH_RS03895	COG1917	Cupin 2, conserved barrel domain protein
BH_RS03900	COG0697	spore germination
BH_RS03930	COG0714	Associated with various cellular activities
BH_RS03960	COG1733	regulation of RNA biosynthetic process
BH_RS03970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BH_RS03985	COG5577	PFAM Coat F domain
BH_RS03990	COG2217	Heavy metal translocating P-type atpase
BH_RS03995	COG2851	Citrate transporter
BH_RS04000	COG0402	S-adenosylhomocysteine deaminase activity
BH_RS04010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BH_RS04015	COG2080	2 iron, 2 sulfur cluster binding
BH_RS04020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BH_RS04030	COG0577	efflux transmembrane transporter activity
BH_RS04035	COG1136	(ABC) transporter
BH_RS04040	COG5002	protein histidine kinase activity
BH_RS04045	COG0745	RESPONSE REGULATOR receiver
BH_RS04050	COG2311	Membrane
BH_RS04055	COG2508	Transcriptional regulator
BH_RS04060	COG3195	allantoin biosynthetic process
BH_RS04060	COG3648	Uricase
BH_RS04065	COG3648	Uricase
BH_RS04065	COG3195	allantoin biosynthetic process
BH_RS04070	COG2351	hydroxyisourate hydrolase activity
BH_RS04080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BH_RS04090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BH_RS04130	COG3730	PTS system glucitol sorbitol-specific
BH_RS04135	COG3732	PTS system glucitol sorbitol-specific
BH_RS04155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BH_RS04160	COG0022	dehydrogenase e1 component
BH_RS04165	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS04170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BH_RS04185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BH_RS04190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BH_RS04195	COG4585	Histidine kinase
BH_RS04205	COG1940	carbohydrate kinase activity
BH_RS04210	COG5578	integral membrane protein
BH_RS04215	COG0383	alpha-mannosidase activity
BH_RS04230	COG3275	phosphorelay sensor kinase activity
BH_RS04235	COG4753	response regulator
BH_RS04235	COG2207	Transcriptional regulator
BH_RS04240	COG4209	transmembrane transport
BH_RS04245	COG0395	ABC-type sugar transport system, permease component
BH_RS04250	COG1653	transport
BH_RS04255	COG1940	carbohydrate kinase activity
BH_RS04260	COG1607	acyl-coa hydrolase
BH_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS04285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BH_RS04290	COG2610	gluconate transmembrane transporter activity
BH_RS04335	COG1132	(ABC) transporter
BH_RS04350	COG1131	(ABC) transporter
BH_RS04355	COG2205	protein histidine kinase activity
BH_RS04360	COG0745	RESPONSE REGULATOR receiver
BH_RS04365	COG4106	trans-aconitate 2-methyltransferase activity
BH_RS04370	COG2244	polysaccharide biosynthetic process
BH_RS04375	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BH_RS04380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS04385	COG2318	DinB family
BH_RS04390	COG1349	DNA-binding transcription factor activity
BH_RS04395	COG1105	Belongs to the carbohydrate kinase PfkB family
BH_RS04400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BH_RS04400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BH_RS04400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BH_RS04415	COG3859	Proton-coupled thiamine transporter YuaJ
BH_RS04420	COG1404	Belongs to the peptidase S8 family
BH_RS04435	COG0018	arginyl-trna synthetase
BH_RS04450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BH_RS04465	COG2076	Multidrug Resistance protein
BH_RS04475	COG1077	Cell shape determining protein MreB Mrl
BH_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS04480	COG1263	PTS System
BH_RS04480	COG2190	(PTS) system
BH_RS04485	COG3711	transcriptional antiterminator
BH_RS04490	COG0561	phosphatase activity
BH_RS04495	COG1349	DNA-binding transcription factor activity
BH_RS04515	COG2207	Transcriptional regulator
BH_RS04520	COG3011	Protein conserved in bacteria
BH_RS04540	COG1404	Belongs to the peptidase S8 family
BH_RS04550	COG0385	Bile acid
BH_RS04560	COG0534	Mate efflux family protein
BH_RS04570	COG0328	RNA-DNA hybrid ribonuclease activity
BH_RS04570	COG3341	Caulimovirus viroplasmin
BH_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS04585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BH_RS04595	COG1522	sequence-specific DNA binding
BH_RS04600	COG2059	Chromate
BH_RS04605	COG2059	Chromate
BH_RS04615	COG0366	Alpha amylase catalytic
BH_RS04620	COG2188	Transcriptional regulator
BH_RS04625	COG1785	Belongs to the alkaline phosphatase family
BH_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BH_RS04635	COG0840	transmembrane signaling receptor activity
BH_RS04640	COG1294	oxidase, subunit
BH_RS04645	COG1271	oxidase subunit
BH_RS04655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BH_RS04665	COG0477	Major facilitator Superfamily
BH_RS04675	COG0534	Mate efflux family protein
BH_RS04680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BH_RS04690	COG0535	radical SAM domain protein
BH_RS04730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BH_RS04735	COG4405	Protein conserved in bacteria
BH_RS04750	COG1609	Transcriptional regulator
BH_RS04755	COG1175	transmembrane transport
BH_RS04760	COG0395	ABC-type sugar transport system, permease component
BH_RS04765	COG5578	integral membrane protein
BH_RS04770	COG1653	transport
BH_RS04775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BH_RS04780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BH_RS04790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BH_RS04795	COG1447	Phosphotransferase system cellobiose-specific component IIA
BH_RS04805	COG1486	melibiose metabolic process
BH_RS04810	COG3394	polysaccharide catabolic process
BH_RS04815	COG2188	Transcriptional regulator
BH_RS04820	COG3328	transposase activity
BH_RS04835	COG1917	Cupin 2, conserved barrel domain protein
BH_RS04840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BH_RS04845	COG0456	acetyltransferase
BH_RS04855	COG2137	regulation of response to DNA damage stimulus
BH_RS04875	COG1988	membrane-bound metal-dependent
BH_RS04885	COG1194	a g-specific adenine glycosylase
BH_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS04910	COG0436	Aminotransferase
BH_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS04930	COG3557	Belongs to the UPF0374 family
BH_RS04935	COG1132	(ABC) transporter
BH_RS04940	COG4129	membrane
BH_RS04945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BH_RS04955	COG0640	Transcriptional regulator
BH_RS04970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BH_RS04975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BH_RS04980	COG3870	Protein conserved in bacteria
BH_RS04985	COG0735	belongs to the Fur family
BH_RS05155	COG4824	toxin secretion phage lysis holin
BH_RS05180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BH_RS05190	COG1511	domain protein
BH_RS05205	COG4499	WXG100 protein secretion system (Wss), protein YukC
BH_RS05210	COG1674	ftsk spoiiie
BH_RS05260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BH_RS05275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BH_RS05275	COG2207	Transcriptional regulator
BH_RS05280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BH_RS05285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BH_RS05290	COG3829	transcription factor binding
BH_RS05300	COG0531	amino acid
BH_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS05310	COG2738	Putative neutral zinc metallopeptidase
BH_RS05315	COG1469	GTP cyclohydrolase I activity
BH_RS05335	COG1309	transcriptional regulator
BH_RS05340	COG1131	(ABC) transporter
BH_RS05350	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS05355	COG0840	transmembrane signaling receptor activity
BH_RS05360	COG0326	Molecular chaperone. Has ATPase activity
BH_RS05365	COG0697	spore germination
BH_RS05370	COG1733	regulation of RNA biosynthetic process
BH_RS05375	COG0655	NAD(P)H dehydrogenase (quinone) activity
BH_RS05380	COG0667	Aldo Keto reductase
BH_RS05390	COG4637	Psort location Cytoplasmic, score
BH_RS05400	COG0737	Belongs to the 5'-nucleotidase family
BH_RS05405	COG0747	negative chemotaxis
BH_RS05415	COG0783	Belongs to the Dps family
BH_RS05430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BH_RS05445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS05450	COG4605	iron ion homeostasis
BH_RS05455	COG4604	ABC transporter, ATP-binding protein
BH_RS05460	COG4607	ABC-type enterochelin transport system periplasmic component
BH_RS05465	COG2766	serine protein kinase
BH_RS05475	COG2718	Belongs to the UPF0229 family
BH_RS05485	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BH_RS05490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BH_RS05510	COG1120	ATPase activity
BH_RS05525	COG1489	DNA binding
BH_RS05560	COG2197	response regulator
BH_RS05590	COG1959	2 iron, 2 sulfur cluster binding
BH_RS05595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BH_RS05595	COG1017	nitric oxide dioxygenase activity
BH_RS05600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BH_RS05605	COG0436	Aminotransferase
BH_RS05620	COG1312	Catalyzes the dehydration of D-mannonate
BH_RS05630	COG4209	transmembrane transport
BH_RS05635	COG0395	ABC-type sugar transport system, permease component
BH_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS05650	COG3546	catalase activity
BH_RS05655	COG0473	3-isopropylmalate dehydrogenase activity
BH_RS05660	COG0179	Fumarylacetoacetate (FAA) hydrolase
BH_RS05665	COG2508	Transcriptional regulator
BH_RS05665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BH_RS05670	COG0454	-acetyltransferase
BH_RS05685	COG3842	ATPase activity
BH_RS05695	COG0395	ABC-type sugar transport system, permease component
BH_RS05705	COG0584	glycerophosphoryl diester phosphodiesterase
BH_RS05710	COG1120	ATPase activity
BH_RS05715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS05720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS05725	COG0058	SHG alpha-glucan phosphorylase activity
BH_RS05730	COG0297	glycogen (starch) synthase activity
BH_RS05735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BH_RS05740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BH_RS05750	COG3153	acetyltransferase
BH_RS05750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BH_RS05760	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BH_RS05765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BH_RS05770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BH_RS05780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BH_RS05790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BH_RS05815	COG0697	spore germination
BH_RS05845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BH_RS05850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BH_RS05855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BH_RS05860	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BH_RS05870	COG0393	Putative heavy-metal-binding
BH_RS05880	COG3401	FG-GAP repeat protein
BH_RS05885	COG2755	lipolytic protein G-D-S-L family
BH_RS05895	COG1653	transport
BH_RS05900	COG1175	transmembrane transport
BH_RS05905	COG0395	ABC-type sugar transport system, permease component
BH_RS05910	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BH_RS05915	COG5578	integral membrane protein
BH_RS05920	COG2972	Histidine kinase
BH_RS05925	COG2207	Transcriptional regulator
BH_RS05925	COG4753	response regulator
BH_RS05935	COG1132	(ABC) transporter
BH_RS05940	COG1132	(ABC) transporter
BH_RS05945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BH_RS05950	COG0733	neurotransmitter:sodium symporter activity
BH_RS05955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BH_RS05960	COG1960	acyl-CoA dehydrogenase activity
BH_RS05965	COG0318	PFAM AMP-dependent synthetase and ligase
BH_RS05970	COG0439	Biotin carboxylase
BH_RS05975	COG0511	ligase activity, forming carbon-carbon bonds
BH_RS05980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BH_RS05985	COG1024	Enoyl-CoA hydratase
BH_RS05990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BH_RS05995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BH_RS06010	COG3842	ATPase activity
BH_RS06015	COG2508	Transcriptional regulator
BH_RS06040	COG0189	ligase activity
BH_RS06050	COG4399	Belongs to the UPF0754 family
BH_RS06055	COG3679	Belongs to the UPF0342 family
BH_RS06060	COG0534	Mate efflux family protein
BH_RS06065	COG0561	phosphatase activity
BH_RS06070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BH_RS06080	COG5002	protein histidine kinase activity
BH_RS06085	COG1132	(ABC) transporter
BH_RS06090	COG1132	(ABC) transporter
BH_RS06100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BH_RS06125	COG1131	(ABC) transporter
BH_RS06130	COG4152	abc transporter atp-binding protein
BH_RS06135	COG1668	transmembrane transport
BH_RS06145	COG0706	membrane insertase activity
BH_RS06160	COG0745	RESPONSE REGULATOR receiver
BH_RS06165	COG2770	Histidine kinase
BH_RS06165	COG2205	protein histidine kinase activity
BH_RS06170	COG2814	Major facilitator Superfamily
BH_RS06175	COG3481	metal-dependent phosphohydrolase, HD sub domain
BH_RS06185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BH_RS06220	COG1846	Transcriptional regulator
BH_RS06235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BH_RS06240	COG0537	adenosine 5'-monophosphoramidase activity
BH_RS06250	COG1131	(ABC) transporter
BH_RS06255	COG4473	ABC transporter
BH_RS06265	COG0785	Cytochrome C biogenesis protein
BH_RS06275	COG1842	Phage shock protein A
BH_RS06285	COG4758	membrane
BH_RS06290	COG4585	Histidine kinase
BH_RS06295	COG2197	response regulator
BH_RS06300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BH_RS06305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BH_RS06310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BH_RS06315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BH_RS06320	COG2070	2-Nitropropane dioxygenase
BH_RS06340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BH_RS06350	COG3290	protein histidine kinase activity
BH_RS06355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BH_RS06360	COG4492	Belongs to the UPF0735 family
BH_RS06365	COG0077	Prephenate dehydratase
BH_RS06370	COG1827	regulation of RNA biosynthetic process
BH_RS06375	COG1104	cysteine desulfurase activity
BH_RS06380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BH_RS06385	COG0157	Belongs to the NadC ModD family
BH_RS06390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BH_RS06410	COG0632	four-way junction helicase activity
BH_RS06415	COG2255	four-way junction helicase activity
BH_RS06425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BH_RS06430	COG0343	queuine tRNA-ribosyltransferase activity
BH_RS06435	COG1862	Preprotein translocase
BH_RS06450	COG2323	membrane
BH_RS06460	COG2244	polysaccharide biosynthetic process
BH_RS06480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BH_RS06485	COG5416	Lipopolysaccharide assembly protein A domain
BH_RS06490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BH_RS06490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BH_RS06495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BH_RS06500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BH_RS06505	COG1490	D-aminoacyl-tRNA deacylase activity
BH_RS06510	COG1653	transport
BH_RS06530	COG0673	inositol 2-dehydrogenase activity
BH_RS06535	COG1082	Xylose isomerase domain protein TIM barrel
BH_RS06540	COG1609	Transcriptional regulator
BH_RS06545	COG0124	histidyl-tRNA synthetase
BH_RS06550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BH_RS06555	COG0460	homoserine dehydrogenase
BH_RS06565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BH_RS06575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BH_RS06580	COG2364	Membrane
BH_RS06585	COG1959	2 iron, 2 sulfur cluster binding
BH_RS06590	COG1104	cysteine desulfurase activity
BH_RS06595	COG0482	sulfurtransferase activity
BH_RS06610	COG3881	PFAM PRC-barrel domain
BH_RS06620	COG0628	permease
BH_RS06625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BH_RS06630	COG4472	Bacterial protein of unknown function (DUF965)
BH_RS06635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BH_RS06640	COG3906	Belongs to the UPF0473 family
BH_RS06645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BH_RS06650	COG4122	O-methyltransferase activity
BH_RS06655	COG0826	peptidase U32
BH_RS06660	COG0826	peptidase U32
BH_RS06665	COG0572	uridine kinase
BH_RS06670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BH_RS06685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BH_RS06710	COG1115	amino acid carrier protein
BH_RS06740	COG2323	membrane
BH_RS06800	COG3397	chitin binding
BH_RS06815	COG0753	catalase activity
BH_RS06830	COG0776	regulation of translation
BH_RS06835	COG1183	phosphatidylcholine synthase activity
BH_RS06840	COG0688	phosphatidylethanolamine metabolic process
BH_RS06850	COG1320	monovalent cation:proton antiporter activity
BH_RS06855	COG2212	antiporter activity
BH_RS06860	COG1863	multisubunit Na H antiporter MnhE subunit
BH_RS06865	COG0651	ATP synthesis coupled electron transport
BH_RS06870	COG1006	Multisubunit Na H antiporter MnhC subunit
BH_RS06875	COG2111	Na H antiporter
BH_RS06880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BH_RS06880	COG2111	Na H antiporter
BH_RS06895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BH_RS06900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BH_RS06905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BH_RS06910	COG1534	Rna-binding protein
BH_RS06915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BH_RS06920	COG1713	HD superfamily hydrolase involved in NAD metabolism
BH_RS06925	COG0799	negative regulation of ribosome biogenesis
BH_RS06930	COG2996	Protein conserved in bacteria
BH_RS06935	COG2226	methyltransferase
BH_RS06940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BH_RS06950	COG1596	polysaccharide export
BH_RS06950	COG1555	photosystem II stabilization
BH_RS06955	COG2131	deaminase
BH_RS06960	COG2333	competence protein COMEC
BH_RS06960	COG0658	competence protein
BH_RS06970	COG1466	dna polymerase III delta subunit
BH_RS06980	COG0268	Binds directly to 16S ribosomal RNA
BH_RS06985	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BH_RS06995	COG0481	GTPase activity
BH_RS07000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BH_RS07005	COG1420	regulation of RNA biosynthetic process
BH_RS07010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BH_RS07015	COG0443	Heat shock 70 kDa protein
BH_RS07025	COG0484	heat shock protein binding
BH_RS07030	COG2264	protein methyltransferase activity
BH_RS07035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BH_RS07040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BH_RS07045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BH_RS07050	COG1283	sodium-dependent phosphate transmembrane transporter activity
BH_RS07055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BH_RS07060	COG1610	YqeY-like protein
BH_RS07065	COG1030	water channel activity
BH_RS07070	COG4864	UPF0365 protein
BH_RS07090	COG1702	phosphate starvation-inducible protein PhoH
BH_RS07095	COG1480	7TM receptor with intracellular HD hydrolase
BH_RS07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BH_RS07105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BH_RS07115	COG0295	cytidine deaminase activity
BH_RS07120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BH_RS07125	COG1381	Involved in DNA repair and RecF pathway recombination
BH_RS07130	COG0752	glycyl-tRNA synthetase alpha subunit
BH_RS07135	COG0751	glycine-tRNA ligase activity
BH_RS07140	COG0517	IMP dehydrogenase activity
BH_RS07145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BH_RS07150	COG1671	Belongs to the UPF0178 family
BH_RS07155	COG0358	DNA primase activity
BH_RS07160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BH_RS07170	COG2010	Cytochrome c
BH_RS07175	COG2384	SAM-dependent methyltransferase
BH_RS07180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BH_RS07190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BH_RS07195	COG1329	Transcriptional regulator
BH_RS07205	COG0513	Belongs to the DEAD box helicase family
BH_RS07210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BH_RS07220	COG5002	protein histidine kinase activity
BH_RS07225	COG1121	(ABC) transporter
BH_RS07230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BH_RS07240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BH_RS07250	COG1121	(ABC) transporter
BH_RS07255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BH_RS07260	COG0735	belongs to the Fur family
BH_RS07270	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BH_RS07275	COG4709	membrane
BH_RS07280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BH_RS07290	COG2814	Major facilitator Superfamily
BH_RS07295	COG4086	secreted protein
BH_RS07310	COG0704	Plays a role in the regulation of phosphate uptake
BH_RS07340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BH_RS07345	COG0477	Major facilitator Superfamily
BH_RS07350	COG0768	penicillin binding
BH_RS07375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BH_RS07380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BH_RS07385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BH_RS07395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BH_RS07405	COG0705	Rhomboid family
BH_RS07405	COG0457	Tetratricopeptide repeat
BH_RS07415	COG0697	spore germination
BH_RS07425	COG4483	Protein conserved in bacteria
BH_RS07430	COG1940	carbohydrate kinase activity
BH_RS07435	COG1027	Aspartate ammonia-lyase
BH_RS07455	COG0352	thiamine-phosphate diphosphorylase activity
BH_RS07465	COG2022	thiamine diphosphate biosynthetic process
BH_RS07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BH_RS07475	COG0351	phosphomethylpyrimidine kinase
BH_RS07485	COG0011	TIGRFAM Protein of
BH_RS07490	COG2153	protein acetylation
BH_RS07495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BH_RS07500	COG2382	esterase
BH_RS07505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BH_RS07515	COG1396	sequence-specific DNA binding
BH_RS07525	COG0114	fumarate hydratase activity
BH_RS07530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BH_RS07535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BH_RS07540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BH_RS07555	COG2818	Glycosylase
BH_RS07560	COG0456	acetyltransferase
BH_RS07580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BH_RS07585	COG0730	response to heat
BH_RS07590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BH_RS07595	COG0765	amino acid transport
BH_RS07600	COG1126	abc transporter atp-binding protein
BH_RS07605	COG4129	membrane
BH_RS07610	COG1376	ErfK ybiS ycfS ynhG family protein
BH_RS07620	COG0346	lactoylglutathione lyase activity
BH_RS07625	COG2195	Cleaves the N-terminal amino acid of tripeptides
BH_RS07640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BH_RS07655	COG2257	FlhB HrpN YscU SpaS Family
BH_RS07660	COG1516	flagellar protein fliS
BH_RS07670	COG1728	Protein conserved in bacteria
BH_RS07685	COG1902	pentaerythritol trinitrate reductase activity
BH_RS07690	COG0517	IMP dehydrogenase activity
BH_RS07705	COG0175	sulfate reduction
BH_RS07710	COG2046	Belongs to the sulfate adenylyltransferase family
BH_RS07715	COG0306	phosphate transporter
BH_RS07720	COG0529	Catalyzes the synthesis of activated sulfate
BH_RS07730	COG2861	carbohydrate metabolic process
BH_RS07735	COG0492	ferredoxin-NADP+ reductase activity
BH_RS07740	COG0789	Transcriptional regulator
BH_RS07745	COG1587	Uroporphyrinogen-III synthase
BH_RS07745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BH_RS07755	COG1648	precorrin-2 dehydrogenase activity
BH_RS07755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BH_RS07770	COG0527	aspartate kinase activity
BH_RS07785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BH_RS07790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BH_RS07795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BH_RS07800	COG0300	oxidoreductase activity
BH_RS07805	COG0367	asparagine synthase
BH_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS07820	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS07835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BH_RS07840	COG2190	(PTS) system
BH_RS07845	COG1609	Transcriptional regulator
BH_RS07855	COG0701	Predicted permease
BH_RS07870	COG1968	undecaprenyl-diphosphatase activity
BH_RS07875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BH_RS07890	COG1379	DNA repair
BH_RS07895	COG1300	Membrane
BH_RS07900	COG0735	belongs to the Fur family
BH_RS07910	COG4974	Belongs to the 'phage' integrase family
BH_RS07915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BH_RS07935	COG3832	glyoxalase III activity
BH_RS07940	COG1686	Belongs to the peptidase S11 family
BH_RS07950	COG2172	sigma factor antagonist activity
BH_RS07955	COG1191	sigma factor activity
BH_RS07965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BH_RS07980	COG0697	spore germination
BH_RS07985	COG0019	diaminopimelate decarboxylase activity
BH_RS07990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BH_RS08005	COG2972	Histidine kinase
BH_RS08005	COG0745	RESPONSE REGULATOR receiver
BH_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS08020	COG3347	Dehydrogenase
BH_RS08025	COG1070	Carbohydrate kinase
BH_RS08030	COG4806	L-rhamnose isomerase
BH_RS08035	COG1349	DNA-binding transcription factor activity
BH_RS08040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BH_RS08040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BH_RS08045	COG0307	riboflavin synthase, alpha
BH_RS08050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BH_RS08050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BH_RS08055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BH_RS08065	COG1547	Domain of unknown function (DUF309)
BH_RS08070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BH_RS08075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BH_RS08085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BH_RS08095	COG2323	membrane
BH_RS08115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BH_RS08130	COG2323	membrane
BH_RS08135	COG1686	Belongs to the peptidase S11 family
BH_RS08140	COG2715	membrane protein required for spore maturation
BH_RS08145	COG0700	Nucleoside recognition
BH_RS08150	COG1187	pseudouridine synthase activity
BH_RS08155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BH_RS08160	COG1333	cytochrome c biogenesis protein
BH_RS08165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BH_RS08170	COG0745	RESPONSE REGULATOR receiver
BH_RS08175	COG5002	protein histidine kinase activity
BH_RS08195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BH_RS08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS08205	COG1120	ATPase activity
BH_RS08210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BH_RS08215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BH_RS08220	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BH_RS08225	COG1492	cobalamin metabolic process
BH_RS08230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BH_RS08245	COG2096	Adenosyltransferase
BH_RS08250	COG2720	vancomycin resistance protein
BH_RS08270	COG0739	heme binding
BH_RS08280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BH_RS08290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BH_RS08295	COG1141	Ferredoxin
BH_RS08300	COG4955	Helix-turn-helix domain
BH_RS08305	COG0514	ATP-dependent DNA helicase (RecQ)
BH_RS08310	COG1266	CAAX protease self-immunity
BH_RS08330	COG2105	PFAM AIG2 family protein
BH_RS08335	COG1473	amidohydrolase
BH_RS08340	COG0456	acetyltransferase
BH_RS08345	COG1595	DNA-templated transcription, initiation
BH_RS08360	COG1408	metallophosphoesterase
BH_RS08370	COG4862	establishment of competence for transformation
BH_RS08375	COG1181	Belongs to the D-alanine--D-alanine ligase family
BH_RS08380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS08385	COG0492	ferredoxin-NADP+ reductase activity
BH_RS08390	COG0252	asparaginase activity
BH_RS08395	COG2339	peptidase activity
BH_RS08400	COG0626	cystathionine gamma-synthase activity
BH_RS08405	COG0626	cystathionine gamma-synthase activity
BH_RS08410	COG0646	methionine synthase
BH_RS08410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BH_RS08415	COG0646	methionine synthase
BH_RS08415	COG1410	methionine synthase
BH_RS08420	COG3773	Cell wall hydrolase
BH_RS08420	COG3409	Peptidoglycan-binding domain 1 protein
BH_RS08425	COG2959	enzyme of heme biosynthesis
BH_RS08435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BH_RS08440	COG0204	Acyl-transferase
BH_RS08445	COG0539	negative regulation of cytoplasmic translation
BH_RS08455	COG1160	GTP binding
BH_RS08460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BH_RS08465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BH_RS08490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BH_RS08495	COG0302	gtp cyclohydrolase
BH_RS08505	COG0142	geranyltranstransferase activity
BH_RS08510	COG2226	methyltransferase
BH_RS08515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BH_RS08520	COG0163	prenyltransferase activity
BH_RS08525	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BH_RS08535	COG0105	UTP biosynthetic process
BH_RS08540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BH_RS08545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BH_RS08550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BH_RS08565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BH_RS08570	COG0134	indole-3-glycerol-phosphate synthase activity
BH_RS08575	COG0135	phosphoribosylanthranilate isomerase activity
BH_RS08580	COG0133	tryptophan synthase activity
BH_RS08585	COG0159	tryptophan synthase activity
BH_RS08590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BH_RS08595	COG0287	Prephenate dehydrogenase
BH_RS08600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BH_RS08615	COG5582	Belongs to the UPF0302 family
BH_RS08625	COG0723	plastoquinol--plastocyanin reductase activity
BH_RS08635	COG2010	Cytochrome c
BH_RS08635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BH_RS08640	COG4347	Protein of unknown function (DUF1405)
BH_RS08650	COG2738	Putative neutral zinc metallopeptidase
BH_RS08655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BH_RS08660	COG1694	Mazg nucleotide pyrophosphohydrolase
BH_RS08665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BH_RS08670	COG1803	Methylglyoxal synthase
BH_RS08675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BH_RS08680	COG0438	transferase activity, transferring glycosyl groups
BH_RS08690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BH_RS08690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BH_RS08700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BH_RS08705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BH_RS08710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BH_RS08720	COG1199	ATP-dependent helicase activity
BH_RS08720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BH_RS08725	COG0402	S-adenosylhomocysteine deaminase activity
BH_RS08740	COG0017	Asparaginyl-tRNA synthetase
BH_RS08745	COG3935	DnaD domain protein
BH_RS08750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BH_RS08760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BH_RS08770	COG4499	WXG100 protein secretion system (Wss), protein YukC
BH_RS08770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BH_RS08775	COG3331	DNA recombination
BH_RS08785	COG0789	Transcriptional regulator
BH_RS08800	COG2860	membrane
BH_RS08810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BH_RS08815	COG0784	Response regulator, receiver
BH_RS08815	COG0835	chemotaxis
BH_RS08820	COG1234	tRNA 3'-trailer cleavage
BH_RS08845	COG1413	lyase activity
BH_RS08855	COG3402	PFAM membrane-flanked domain
BH_RS08860	COG3428	Bacterial PH domain
BH_RS08890	COG0070	glutamate synthase
BH_RS08890	COG0069	glutamate synthase activity
BH_RS08890	COG0067	glutamate synthase
BH_RS08895	COG0493	'glutamate synthase
BH_RS08925	COG2508	Transcriptional regulator
BH_RS08935	COG0460	homoserine dehydrogenase
BH_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS08945	COG0006	proline dipeptidase activity
BH_RS08960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BH_RS08975	COG0561	phosphatase activity
BH_RS08980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BH_RS08995	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BH_RS09015	COG1136	(ABC) transporter
BH_RS09020	COG2124	cytochrome p450
BH_RS09035	COG3048	D-serine ammonia-lyase activity
BH_RS09040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BH_RS09045	COG1205	dead DEAH box helicase
BH_RS09045	COG1111	helicase
BH_RS09050	COG3359	exonuclease
BH_RS09060	COG4474	Belongs to the UPF0398 family
BH_RS09065	COG3599	regulation of cell shape
BH_RS09070	COG0328	RNA-DNA hybrid ribonuclease activity
BH_RS09075	COG0116	Belongs to the methyltransferase superfamily
BH_RS09080	COG1115	amino acid carrier protein
BH_RS09090	COG1597	lipid kinase activity
BH_RS09095	COG2814	Major facilitator Superfamily
BH_RS09100	COG0584	glycerophosphoryl diester phosphodiesterase
BH_RS09110	COG0346	lactoylglutathione lyase activity
BH_RS09115	COG1834	amidinotransferase
BH_RS09145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BH_RS09150	COG2207	Transcriptional regulator
BH_RS09150	COG0662	Cupin 2, conserved barrel domain protein
BH_RS09155	COG0583	DNA-binding transcription factor activity
BH_RS09165	COG1690	Belongs to the RtcB family
BH_RS09170	COG0523	cobalamin synthesis protein
BH_RS09180	COG1199	ATP-dependent helicase activity
BH_RS09185	COG1966	Carbon starvation protein
BH_RS09195	COG0003	Pfam Anion-transporting ATPase
BH_RS09210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS09215	COG0444	Belongs to the ABC transporter superfamily
BH_RS09220	COG4608	Belongs to the ABC transporter superfamily
BH_RS09225	COG1744	ABC transporter substrate-binding protein PnrA-like
BH_RS09230	COG3852	Histidine kinase
BH_RS09235	COG2340	Cysteine-rich secretory protein family
BH_RS09240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BH_RS09250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BH_RS09275	COG1078	dGTPase activity
BH_RS09300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BH_RS09305	COG1984	allophanate hydrolase subunit 2
BH_RS09310	COG1414	Transcriptional regulator
BH_RS09315	COG1914	H( )-stimulated, divalent metal cation uptake system
BH_RS09320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BH_RS09325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BH_RS09330	COG0022	dehydrogenase e1 component
BH_RS09335	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS09340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BH_RS09345	COG3284	Transcriptional regulator
BH_RS09350	COG0840	transmembrane signaling receptor activity
BH_RS09355	COG4122	O-methyltransferase activity
BH_RS09360	COG1063	alcohol dehydrogenase
BH_RS09365	COG1620	l-lactate permease
BH_RS09370	COG0247	lactate metabolic process
BH_RS09375	COG1139	Iron-sulfur cluster binding protein
BH_RS09380	COG1556	Lactate utilization protein
BH_RS09385	COG2186	Transcriptional regulator
BH_RS09395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BH_RS09410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BH_RS09445	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS09455	COG1024	Enoyl-CoA hydratase
BH_RS09460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BH_RS09485	COG1609	Transcriptional regulator
BH_RS09490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS09490	COG1263	PTS System
BH_RS09495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BH_RS09500	COG1621	beta-fructofuranosidase activity
BH_RS09515	COG3534	alpha-L-arabinofuranosidase
BH_RS09520	COG0371	Dehydrogenase
BH_RS09525	COG5578	integral membrane protein
BH_RS09535	COG1175	transmembrane transport
BH_RS09540	COG0395	ABC-type sugar transport system, permease component
BH_RS09545	COG3940	Belongs to the glycosyl hydrolase 43 family
BH_RS09565	COG0235	Class ii aldolase
BH_RS09570	COG1069	ribulokinase activity
BH_RS09575	COG2160	L-arabinose isomerase activity
BH_RS09580	COG3534	alpha-L-arabinofuranosidase
BH_RS09585	COG1609	Transcriptional regulator
BH_RS09600	COG3507	Belongs to the glycosyl hydrolase 43 family
BH_RS09620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BH_RS09635	COG2357	RelA SpoT domain protein
BH_RS09645	COG1309	transcriptional regulator
BH_RS09650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BH_RS09660	COG2318	DinB family
BH_RS09670	COG2318	DinB family
BH_RS09675	COG0494	nUDIX hydrolase
BH_RS09680	COG0768	penicillin binding
BH_RS09700	COG1797	cobyrinic acid a,c-diamide synthase activity
BH_RS09710	COG0488	(ABC) transporter
BH_RS09725	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS09735	COG1501	Belongs to the glycosyl hydrolase 31 family
BH_RS09740	COG1917	Cupin 2, conserved barrel domain protein
BH_RS09740	COG2207	Transcriptional regulator
BH_RS09745	COG5578	integral membrane protein
BH_RS09750	COG1472	Belongs to the glycosyl hydrolase 3 family
BH_RS09755	COG2972	Histidine kinase
BH_RS09765	COG4209	transmembrane transport
BH_RS09770	COG0395	ABC-type sugar transport system, permease component
BH_RS09805	COG3852	Histidine kinase
BH_RS09830	COG1175	transmembrane transport
BH_RS09835	COG0395	ABC-type sugar transport system, permease component
BH_RS09840	COG5578	integral membrane protein
BH_RS09845	COG1609	Transcriptional regulator
BH_RS09855	COG1404	Belongs to the peptidase S8 family
BH_RS09860	COG0697	spore germination
BH_RS09865	COG0318	PFAM AMP-dependent synthetase and ligase
BH_RS09870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BH_RS09875	COG0697	spore germination
BH_RS09885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BH_RS09900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BH_RS09905	COG0506	proline dehydrogenase activity
BH_RS09915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BH_RS09930	COG0745	RESPONSE REGULATOR receiver
BH_RS09935	COG5002	protein histidine kinase activity
BH_RS09960	COG0384	phenazine biosynthesis protein PhzF
BH_RS09965	COG1063	alcohol dehydrogenase
BH_RS09985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BH_RS10020	COG1309	transcriptional regulator
BH_RS10025	COG2814	Major facilitator Superfamily
BH_RS10030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BH_RS10045	COG2323	membrane
BH_RS10060	COG2323	membrane
BH_RS10065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BH_RS10080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BH_RS10095	COG0693	protein deglycase activity
BH_RS10095	COG0753	catalase activity
BH_RS10105	COG2986	histidine ammonia-lyase
BH_RS10110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BH_RS10115	COG1228	amidohydrolase
BH_RS10120	COG0010	Belongs to the arginase family
BH_RS10125	COG2056	Na+-H+ antiporter family
BH_RS10130	COG0457	Tetratricopeptide repeat
BH_RS10135	COG0697	spore germination
BH_RS10160	COG2508	Transcriptional regulator
BH_RS10165	COG1250	3-hydroxyacyl-CoA dehydrogenase
BH_RS10170	COG1024	Enoyl-CoA hydratase
BH_RS10175	COG0183	Belongs to the thiolase family
BH_RS10180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BH_RS10190	COG0179	Fumarylacetoacetate (FAA) hydrolase
BH_RS10220	COG0318	PFAM AMP-dependent synthetase and ligase
BH_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS10250	COG0745	RESPONSE REGULATOR receiver
BH_RS10250	COG2972	Histidine kinase
BH_RS10265	COG3279	Response regulator of the LytR AlgR family
BH_RS10275	COG1609	Transcriptional regulator
BH_RS10280	COG2182	Extracellular solute-binding protein
BH_RS10285	COG1175	transmembrane transport
BH_RS10290	COG3833	ABC-type maltose transport systems, permease component
BH_RS10295	COG1874	Beta-galactosidase
BH_RS10300	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BH_RS10305	COG0488	(ABC) transporter
BH_RS10345	COG5646	InterPro IPR014922
BH_RS10365	COG0312	modulator of DNA gyrase
BH_RS10375	COG2814	Major facilitator Superfamily
BH_RS10385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BH_RS10425	COG0457	Tetratricopeptide repeat
BH_RS10430	COG0431	NADPH-dependent FMN reductase
BH_RS10435	COG2226	methyltransferase
BH_RS10465	COG0586	Pfam SNARE associated Golgi protein
BH_RS10470	COG0500	methyltransferase
BH_RS10475	COG1683	Conserved Protein
BH_RS10485	COG1846	Transcriptional regulator
BH_RS10550	COG0747	negative chemotaxis
BH_RS10555	COG0601	transmembrane transport
BH_RS10560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS10565	COG0444	Belongs to the ABC transporter superfamily
BH_RS10570	COG1124	(ABC) transporter
BH_RS10580	COG1404	Belongs to the peptidase S8 family
BH_RS10610	COG0640	Transcriptional regulator
BH_RS10620	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BH_RS10630	COG2133	pyrroloquinoline quinone binding
BH_RS10645	COG3328	transposase activity
BH_RS10650	COG0583	DNA-binding transcription factor activity
BH_RS10660	COG4585	Histidine kinase
BH_RS10665	COG2197	response regulator
BH_RS10670	COG1131	(ABC) transporter
BH_RS10685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS10690	COG0583	DNA-binding transcription factor activity
BH_RS10710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BH_RS10720	COG5578	integral membrane protein
BH_RS10725	COG2207	Transcriptional regulator
BH_RS10725	COG2207	Transcriptional regulator
BH_RS10725	COG4753	response regulator
BH_RS10725	COG4753	response regulator
BH_RS10730	COG2972	Histidine kinase
BH_RS10740	COG4209	transmembrane transport
BH_RS10745	COG0395	ABC-type sugar transport system, permease component
BH_RS10760	COG2814	Major facilitator Superfamily
BH_RS10765	COG0583	DNA-binding transcription factor activity
BH_RS10770	COG2197	response regulator
BH_RS10780	COG3693	PFAM glycoside hydrolase, family 10
BH_RS10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BH_RS10795	COG2197	response regulator
BH_RS10805	COG1396	sequence-specific DNA binding
BH_RS10825	COG0681	Belongs to the peptidase S26 family
BH_RS10840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BH_RS10850	COG0247	lactate metabolic process
BH_RS10855	COG0277	FAD linked oxidase domain protein
BH_RS10860	COG1414	Transcriptional regulator
BH_RS10865	COG1988	membrane-bound metal-dependent
BH_RS10870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BH_RS10875	COG0187	DNA topoisomerase II activity
BH_RS10880	COG1832	CoA-binding protein
BH_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS10895	COG1309	transcriptional regulator
BH_RS10900	COG1511	domain protein
BH_RS10910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BH_RS10915	COG4841	protein insertion into membrane
BH_RS10940	COG1011	Hydrolase
BH_RS10945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BH_RS10950	COG1247	-acetyltransferase
BH_RS10955	COG0656	L-ascorbic acid biosynthetic process
BH_RS10960	COG0346	lactoylglutathione lyase activity
BH_RS10965	COG3069	C4-dicarboxylate transmembrane transporter activity
BH_RS10970	COG1587	Uroporphyrinogen-III synthase
BH_RS10985	COG0673	inositol 2-dehydrogenase activity
BH_RS10990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BH_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS11000	COG1349	DNA-binding transcription factor activity
BH_RS11010	COG1280	lysine exporter protein (LysE YggA)
BH_RS11015	COG1113	amino acid transport
BH_RS11025	COG2151	metal-sulfur cluster biosynthetic enzyme
BH_RS11030	COG0400	carboxylic ester hydrolase activity
BH_RS11035	COG0346	lactoylglutathione lyase activity
BH_RS11045	COG0697	spore germination
BH_RS11050	COG1960	acyl-CoA dehydrogenase activity
BH_RS11055	COG0542	response to heat
BH_RS11060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BH_RS11075	COG1404	Belongs to the peptidase S8 family
BH_RS11095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BH_RS11100	COG3546	catalase activity
BH_RS11115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BH_RS11125	COG0436	Aminotransferase
BH_RS11140	COG0180	Tryptophanyl-tRNA synthetase
BH_RS11150	COG0586	Pfam SNARE associated Golgi protein
BH_RS11165	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS11170	COG0567	Dehydrogenase, E1 component
BH_RS11180	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BH_RS11185	COG3285	dna ligase
BH_RS11185	COG1793	dna ligase
BH_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS11195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BH_RS11205	COG2197	response regulator
BH_RS11225	COG1263	PTS System
BH_RS11225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS11240	COG1609	Transcriptional regulator
BH_RS11245	COG0673	inositol 2-dehydrogenase activity
BH_RS11250	COG0673	inositol 2-dehydrogenase activity
BH_RS11255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BH_RS11265	COG0395	ABC-type sugar transport system, permease component
BH_RS11270	COG1175	transmembrane transport
BH_RS11275	COG1653	transport
BH_RS11280	COG1609	Transcriptional regulator
BH_RS11285	COG1486	melibiose metabolic process
BH_RS11290	COG2207	Transcriptional regulator
BH_RS11310	COG0745	RESPONSE REGULATOR receiver
BH_RS11325	COG0778	Nitroreductase
BH_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS11335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BH_RS11345	COG2312	Erythromycin esterase
BH_RS11350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BH_RS11360	COG0720	synthase
BH_RS11365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BH_RS11370	COG2309	aminopeptidase activity
BH_RS11390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BH_RS11395	COG3314	Sporulation integral membrane protein YlbJ
BH_RS11405	COG4841	protein insertion into membrane
BH_RS11415	COG1509	lysine 2,3-aminomutase activity
BH_RS11430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BH_RS11435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BH_RS11440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BH_RS11450	COG0784	Response regulator, receiver
BH_RS11450	COG0835	chemotaxis
BH_RS11455	COG5002	protein histidine kinase activity
BH_RS11455	COG5002	protein histidine kinase activity
BH_RS11460	COG0745	RESPONSE REGULATOR receiver
BH_RS11475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BH_RS11490	COG1119	ATPase activity
BH_RS11515	COG0840	transmembrane signaling receptor activity
BH_RS11525	COG2200	EAL domain
BH_RS11530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BH_RS11535	COG2267	carboxylic ester hydrolase activity
BH_RS11540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BH_RS11550	COG0613	PHP domain protein
BH_RS11560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BH_RS11575	COG0824	Thioesterase
BH_RS11580	COG0464	growth
BH_RS11595	COG3858	chitin binding
BH_RS11595	COG1388	LysM domain
BH_RS11600	COG0398	Pfam SNARE associated Golgi protein
BH_RS11615	COG2323	membrane
BH_RS11620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BH_RS11635	COG1607	acyl-coa hydrolase
BH_RS11640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BH_RS11650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BH_RS11655	COG0438	transferase activity, transferring glycosyl groups
BH_RS11670	COG1288	antiporter activity
BH_RS11675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BH_RS11680	COG1082	Xylose isomerase domain protein TIM barrel
BH_RS11690	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS11695	COG1609	Transcriptional regulator
BH_RS11700	COG0191	fructose-bisphosphate aldolase activity
BH_RS11705	COG1082	Xylose isomerase domain protein TIM barrel
BH_RS11710	COG0673	inositol 2-dehydrogenase activity
BH_RS11715	COG1082	Xylose isomerase domain protein TIM barrel
BH_RS11720	COG3962	Belongs to the TPP enzyme family
BH_RS11725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BH_RS11730	COG3718	enzyme involved in inositol metabolism
BH_RS11735	COG1172	Belongs to the binding-protein-dependent transport system permease family
BH_RS11740	COG1129	ABC transporter
BH_RS11750	COG0667	Aldo Keto reductase
BH_RS11775	COG0686	Belongs to the AlaDH PNT family
BH_RS11785	COG2226	methyltransferase
BH_RS11795	COG4846	Membrane protein involved in cytochrome C biogenesis
BH_RS11800	COG1132	(ABC) transporter
BH_RS11805	COG1132	(ABC) transporter
BH_RS11840	COG2801	Transposase and inactivated derivatives
BH_RS11875	COG3763	UPF0154 protein
BH_RS11885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BH_RS11890	COG4224	UPF0291 protein
BH_RS11895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BH_RS11905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BH_RS11920	COG0174	glutamine synthetase
BH_RS11925	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BH_RS11930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BH_RS11935	COG0464	growth
BH_RS11945	COG1923	regulation of RNA biosynthetic process
BH_RS11950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BH_RS11955	COG2521	methyltransferase
BH_RS11955	COG2136	Putative SAM-dependent methyltransferase
BH_RS11960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BH_RS11965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BH_RS11975	COG4550	Control of competence regulator ComK, YlbF/YmcA
BH_RS11980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BH_RS11985	COG1013	pyruvate-flavodoxin oxidoreductase activity
BH_RS11995	COG2359	stage V sporulation protein S
BH_RS12000	COG1692	metallophosphoesterase
BH_RS12010	COG1418	mRNA catabolic process
BH_RS12035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BH_RS12040	COG0513	Belongs to the DEAD box helicase family
BH_RS12045	COG1058	Belongs to the CinA family
BH_RS12045	COG1546	Belongs to the CinA family
BH_RS12050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BH_RS12055	COG1666	GTP binding
BH_RS12060	COG1426	Protein conserved in bacteria
BH_RS12075	COG0300	oxidoreductase activity
BH_RS12080	COG0612	Peptidase, M16
BH_RS12085	COG0612	Peptidase, M16
BH_RS12090	COG2188	Transcriptional regulator
BH_RS12095	COG1674	ftsk spoiiie
BH_RS12105	COG0740	serine-type endopeptidase activity
BH_RS12110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BH_RS12115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BH_RS12120	COG0527	aspartate kinase activity
BH_RS12125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BH_RS12130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BH_RS12135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BH_RS12140	COG1873	PFAM PRC-barrel domain
BH_RS12145	COG0612	Peptidase, M16
BH_RS12150	COG0726	polysaccharide deacetylase
BH_RS12155	COG1185	polyribonucleotide nucleotidyltransferase activity
BH_RS12160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BH_RS12165	COG0196	riboflavin kinase activity
BH_RS12170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BH_RS12175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BH_RS12180	COG1550	Protein conserved in bacteria
BH_RS12185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BH_RS12190	COG1358	cellular component organization or biogenesis
BH_RS12195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BH_RS12200	COG0195	Participates in both transcription termination and antitermination
BH_RS12205	COG0779	Required for maturation of 30S ribosomal subunits
BH_RS12210	COG2176	DNA-directed DNA polymerase activity
BH_RS12215	COG0442	prolyl-tRNA aminoacylation
BH_RS12220	COG0750	zinc metalloprotease
BH_RS12225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BH_RS12230	COG4589	Belongs to the CDS family
BH_RS12235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BH_RS12240	COG0233	cytoplasmic translational termination
BH_RS12245	COG0528	UMP kinase activity
BH_RS12250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BH_RS12255	COG0052	Belongs to the universal ribosomal protein uS2 family
BH_RS12275	COG1191	sigma factor activity
BH_RS12285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BH_RS12290	COG1776	CheC inhibitor of MCP methylation
BH_RS12295	COG2201	protein-glutamate methylesterase activity
BH_RS12300	COG0455	bacterial-type flagellum organization
BH_RS12305	COG1419	protein localization to endoplasmic reticulum
BH_RS12310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BH_RS12315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BH_RS12320	COG1684	flagellar biosynthetic protein fliR
BH_RS12325	COG1987	bacterial-type flagellum assembly
BH_RS12330	COG1338	Plays a role in the flagellum-specific transport system
BH_RS12335	COG3190	flagellar
BH_RS12340	COG2201	protein-glutamate methylesterase activity
BH_RS12345	COG1776	CheC inhibitor of MCP methylation
BH_RS12345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BH_RS12350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BH_RS12360	COG1582	Flagellar protein (FlbD)
BH_RS12365	COG4786	Flagellar basal body rod
BH_RS12375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BH_RS12395	COG1157	protein secretion by the type III secretion system
BH_RS12400	COG1317	bacterial-type flagellum organization
BH_RS12405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BH_RS12410	COG1766	The M ring may be actively involved in energy transduction
BH_RS12415	COG1677	Flagellar hook-basal body complex protein FliE
BH_RS12420	COG1558	bacterial-type flagellum-dependent cell motility
BH_RS12425	COG1815	bacterial-type flagellum-dependent cell motility
BH_RS12430	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BH_RS12435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BH_RS12440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BH_RS12445	COG4974	Belongs to the 'phage' integrase family
BH_RS12450	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BH_RS12455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BH_RS12460	COG0758	DNA mediated transformation
BH_RS12465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BH_RS12470	COG0045	succinate-CoA ligase (ADP-forming) activity
BH_RS12485	COG2257	FlhB HrpN YscU SpaS Family
BH_RS12495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BH_RS12510	COG0335	large ribosomal subunit rRNA binding
BH_RS12515	COG0336	Belongs to the RNA methyltransferase TrmD family
BH_RS12520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BH_RS12530	COG1837	Belongs to the UPF0109 family
BH_RS12535	COG0228	four-way junction DNA binding
BH_RS12540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BH_RS12545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BH_RS12550	COG0552	protein localization to endoplasmic reticulum
BH_RS12555	COG1196	nuclear chromosome segregation
BH_RS12560	COG4840	Belongs to the UPF0435 family
BH_RS12565	COG0571	ribonuclease III activity
BH_RS12570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BH_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS12580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BH_RS12585	COG0416	fatty acid biosynthetic process
BH_RS12590	COG1349	DNA-binding transcription factor activity
BH_RS12595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BH_RS12600	COG1760	l-serine dehydratase
BH_RS12605	COG1760	l-serine dehydratase
BH_RS12610	COG1461	Dihydroxyacetone kinase
BH_RS12615	COG1302	Protein conserved in bacteria
BH_RS12620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BH_RS12630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BH_RS12635	COG1162	GTPase activity
BH_RS12640	COG2815	serine threonine protein kinase
BH_RS12640	COG0515	serine threonine protein kinase
BH_RS12645	COG0631	protein serine/threonine phosphatase activity
BH_RS12650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BH_RS12655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BH_RS12655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BH_RS12660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BH_RS12665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BH_RS12670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BH_RS12675	COG1758	RNA polymerase activity
BH_RS12680	COG0194	GDP metabolic process
BH_RS12685	COG2052	Domain of unknown function (DUF370)
BH_RS12690	COG1561	YicC-like family, N-terminal region
BH_RS12695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BH_RS12745	COG2826	transposase and inactivated derivatives, IS30 family
BH_RS12755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BH_RS12760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BH_RS12765	COG2223	nitrite transmembrane transporter activity
BH_RS12770	COG5609	conserved protein (DUF2294)
BH_RS12780	COG2226	methyltransferase
BH_RS12785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BH_RS12790	COG0284	orotidine-5'-phosphate decarboxylase activity
BH_RS12795	COG0167	dihydroorotate dehydrogenase activity
BH_RS12800	COG0543	2 iron, 2 sulfur cluster binding
BH_RS12805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BH_RS12810	COG0505	Belongs to the CarA family
BH_RS12815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BH_RS12820	COG0540	Belongs to the ATCase OTCase family
BH_RS12825	COG2233	PERMEase
BH_RS12830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BH_RS12835	COG0564	pseudouridine synthase activity
BH_RS12840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BH_RS12845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BH_RS12850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BH_RS12855	COG3599	regulation of cell shape
BH_RS12860	COG2302	S4 RNA-binding domain
BH_RS12865	COG0762	integral membrane protein
BH_RS12870	COG1799	cell septum assembly
BH_RS12875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BH_RS12880	COG1496	oxidoreductase activity
BH_RS12885	COG1873	PFAM PRC-barrel domain
BH_RS12890	COG0861	Integral membrane protein TerC family
BH_RS12895	COG1191	sigma factor activity
BH_RS12900	COG1191	sigma factor activity
BH_RS12910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BH_RS12915	COG0849	cell division
BH_RS12920	COG3856	small basic protein
BH_RS12925	COG3879	Bacterial protein of unknown function (DUF881)
BH_RS12930	COG3879	Bacterial protein of unknown function (DUF881)
BH_RS12935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BH_RS12940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BH_RS12945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BH_RS12950	COG0772	Belongs to the SEDS family
BH_RS12955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BH_RS12965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BH_RS12970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BH_RS12975	COG0768	penicillin binding
BH_RS12980	COG0768	penicillin binding
BH_RS12985	COG4839	cell division protein FtsL
BH_RS12990	COG0275	rRNA processing
BH_RS12995	COG2001	Belongs to the MraZ family
BH_RS13000	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BH_RS13010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BH_RS13015	COG0454	-acetyltransferase
BH_RS13025	COG1024	Enoyl-CoA hydratase
BH_RS13030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BH_RS13035	COG1399	metal-binding, possibly nucleic acid-binding protein
BH_RS13040	COG1323	Belongs to the UPF0348 family
BH_RS13045	COG3480	Lon protease (S16) C-terminal proteolytic domain
BH_RS13050	COG1752	Esterase of the alpha-beta hydrolase superfamily
BH_RS13055	COG3314	Sporulation integral membrane protein YlbJ
BH_RS13060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BH_RS13065	COG0742	ribosomal rna small subunit methyltransferase
BH_RS13075	COG2814	Major facilitator Superfamily
BH_RS13085	COG4471	UPF0298 protein
BH_RS13095	COG3679	Belongs to the UPF0342 family
BH_RS13100	COG4294	response to UV
BH_RS13135	COG2340	Cysteine-rich secretory protein family
BH_RS13140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BH_RS13150	COG0628	permease
BH_RS13160	COG2322	membrane
BH_RS13165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BH_RS13170	COG1845	cytochrome c oxidase, subunit III
BH_RS13175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BH_RS13180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BH_RS13180	COG2010	Cytochrome c
BH_RS13185	COG0109	protoheme IX farnesyltransferase activity
BH_RS13190	COG1612	heme a metabolic process
BH_RS13220	COG0076	glutamate decarboxylase activity
BH_RS13230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BH_RS13235	COG4838	Belongs to the UPF0358 family
BH_RS13240	COG2066	Belongs to the glutaminase family
BH_RS13245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BH_RS13250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BH_RS13260	COG4896	Protein conserved in bacteria
BH_RS13270	COG1217	gtp-binding protein TYPA
BH_RS13280	COG2084	Dehydrogenase
BH_RS13285	COG0483	inositol monophosphate 1-phosphatase activity
BH_RS13295	COG4493	Belongs to the UPF0637 family
BH_RS13300	COG4476	Belongs to the UPF0223 family
BH_RS13310	COG1982	Orn Lys Arg decarboxylase major
BH_RS13330	COG4129	membrane
BH_RS13335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BH_RS13345	COG1725	Transcriptional regulator
BH_RS13350	COG1131	(ABC) transporter
BH_RS13375	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS13380	COG0022	dehydrogenase e1 component
BH_RS13400	COG0242	peptide deformylase activity
BH_RS13405	COG0561	phosphatase activity
BH_RS13410	COG5503	Protein of unknown function (DUF1447)
BH_RS13415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BH_RS13420	COG0569	domain protein
BH_RS13425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BH_RS13430	COG0450	alkyl hydroperoxide reductase
BH_RS13435	COG0668	transmembrane transport
BH_RS13450	COG1473	amidohydrolase
BH_RS13455	COG2171	N-acyltransferase activity
BH_RS13465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BH_RS13465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BH_RS13470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BH_RS13470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BH_RS13475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BH_RS13480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BH_RS13485	COG1737	Transcriptional regulator
BH_RS13495	COG2224	Isocitrate lyase
BH_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BH_RS13505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BH_RS13510	COG1116	anion transmembrane transporter activity
BH_RS13515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BH_RS13520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BH_RS13525	COG0668	transmembrane transport
BH_RS13545	COG0438	transferase activity, transferring glycosyl groups
BH_RS13550	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BH_RS13555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BH_RS13560	COG0561	phosphatase activity
BH_RS13570	COG2271	Major facilitator Superfamily
BH_RS13575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BH_RS13585	COG0577	efflux transmembrane transporter activity
BH_RS13595	COG1136	(ABC) transporter
BH_RS13600	COG5002	protein histidine kinase activity
BH_RS13605	COG0745	RESPONSE REGULATOR receiver
BH_RS13610	COG0501	Belongs to the peptidase M48B family
BH_RS13615	COG0673	inositol 2-dehydrogenase activity
BH_RS13630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BH_RS13635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BH_RS13650	COG0583	DNA-binding transcription factor activity
BH_RS13655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BH_RS13660	COG1115	amino acid carrier protein
BH_RS13665	COG0784	Response regulator, receiver
BH_RS13670	COG4191	Histidine kinase
BH_RS13675	COG2066	Belongs to the glutaminase family
BH_RS13680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS13685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BH_RS13690	COG0662	Cupin 2, conserved barrel domain protein
BH_RS13705	COG3250	beta-galactosidase activity
BH_RS13725	COG2972	Histidine kinase
BH_RS13730	COG2207	Transcriptional regulator
BH_RS13730	COG4753	response regulator
BH_RS13735	COG0247	lactate metabolic process
BH_RS13740	COG0277	FAD linked oxidase domain protein
BH_RS13745	COG3835	regulator
BH_RS13775	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS13790	COG0506	proline dehydrogenase activity
BH_RS13795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BH_RS13810	COG1742	UPF0060 membrane protein
BH_RS13825	COG0697	spore germination
BH_RS13830	COG2249	NAD(P)H dehydrogenase (quinone) activity
BH_RS13835	COG2211	Major facilitator Superfamily
BH_RS13840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BH_RS13845	COG4565	transcriptional regulatory protein
BH_RS13850	COG3290	protein histidine kinase activity
BH_RS13865	COG0747	negative chemotaxis
BH_RS13875	COG1070	Carbohydrate kinase
BH_RS13880	COG2115	Belongs to the xylose isomerase family
BH_RS13885	COG1940	carbohydrate kinase activity
BH_RS13895	COG0803	Belongs to the bacterial solute-binding protein 9 family
BH_RS13895	COG3443	Belongs to the bacterial solute-binding protein 9 family
BH_RS13900	COG0508	dehydrogenase complex catalyzes the overall conversion of
BH_RS13905	COG0022	dehydrogenase e1 component
BH_RS13910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BH_RS13915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BH_RS13920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS13925	COG3290	protein histidine kinase activity
BH_RS13925	COG3829	transcription factor binding
BH_RS13940	COG0463	Glycosyl transferase, family 2
BH_RS13960	COG0745	RESPONSE REGULATOR receiver
BH_RS13970	COG0750	zinc metalloprotease
BH_RS13975	COG0497	DNA recombination
BH_RS13980	COG1438	arginine binding
BH_RS13985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BH_RS13990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BH_RS14000	COG0142	geranyltranstransferase activity
BH_RS14005	COG1722	exodeoxyribonuclease VII activity
BH_RS14010	COG1570	exodeoxyribonuclease VII activity
BH_RS14015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BH_RS14020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BH_RS14025	COG1302	Protein conserved in bacteria
BH_RS14030	COG0439	Biotin carboxylase
BH_RS14035	COG0511	ligase activity, forming carbon-carbon bonds
BH_RS14080	COG3854	ATPases associated with a variety of cellular activities
BH_RS14090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BH_RS14095	COG0006	proline dipeptidase activity
BH_RS14100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BH_RS14110	COG3872	metal-dependent enzyme
BH_RS14120	COG1752	Esterase of the alpha-beta hydrolase superfamily
BH_RS14130	COG1321	iron dependent repressor
BH_RS14135	COG1533	DNA photolyase activity
BH_RS14145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BH_RS14155	COG0095	Lipoate-protein ligase
BH_RS14160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BH_RS14165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BH_RS14170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BH_RS14175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BH_RS14180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BH_RS14200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BH_RS14235	COG4537	Required for transformation and DNA binding
BH_RS14245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BH_RS14295	COG0386	Belongs to the glutathione peroxidase family
BH_RS14300	COG1459	type II secretion system
BH_RS14305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BH_RS14320	COG0210	DNA helicase
BH_RS14325	COG1418	mRNA catabolic process
BH_RS14370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BH_RS14375	COG0589	response to stress
BH_RS14375	COG0475	glutathione-regulated potassium exporter activity
BH_RS14380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BH_RS14390	COG0564	pseudouridine synthase activity
BH_RS14395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BH_RS14400	COG2357	RelA SpoT domain protein
BH_RS14415	COG0741	lytic transglycosylase activity
BH_RS14420	COG0243	molybdopterin cofactor binding
BH_RS14425	COG2346	COG2346, Truncated hemoglobins
BH_RS14430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BH_RS14435	COG1164	Oligoendopeptidase f
BH_RS14440	COG4469	Competence protein
BH_RS14445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BH_RS14450	COG4862	establishment of competence for transformation
BH_RS14455	COG0861	Integral membrane protein TerC family
BH_RS14460	COG1393	Belongs to the ArsC family
BH_RS14475	COG1272	protein, Hemolysin III
BH_RS14480	COG1418	mRNA catabolic process
BH_RS14490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BH_RS14500	COG0180	Tryptophanyl-tRNA synthetase
BH_RS14515	COG5504	Zn-dependent protease
BH_RS14520	COG1072	(Pantothenic acid kinase))
BH_RS14530	COG1686	Belongs to the peptidase S11 family
BH_RS14535	COG2340	Cysteine-rich secretory protein family
BH_RS14540	COG3773	Cell wall hydrolase
BH_RS14550	COG0617	tRNA 3'-terminal CCA addition
BH_RS14555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BH_RS14560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BH_RS14580	COG2226	methyltransferase
BH_RS14590	COG1744	ABC transporter substrate-binding protein PnrA-like
BH_RS14600	COG2267	carboxylic ester hydrolase activity
BH_RS14610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BH_RS14615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BH_RS14620	COG0505	Belongs to the CarA family
BH_RS14625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BH_RS14630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BH_RS14635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BH_RS14640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BH_RS14655	COG0366	Alpha amylase catalytic
BH_RS14660	COG1999	signal sequence binding
BH_RS14665	COG3336	cytochrome c oxidase
BH_RS14670	COG0561	phosphatase activity
BH_RS14685	COG1396	sequence-specific DNA binding
BH_RS14690	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BH_RS14705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BH_RS14720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BH_RS14725	COG1073	alpha beta
BH_RS14735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BH_RS14740	COG0628	permease
BH_RS14750	COG1609	Transcriptional regulator
BH_RS14755	COG3833	ABC-type maltose transport systems, permease component
BH_RS14760	COG1175	transmembrane transport
BH_RS14765	COG2182	Extracellular solute-binding protein
BH_RS14785	COG3480	Lon protease (S16) C-terminal proteolytic domain
BH_RS14795	COG1280	lysine exporter protein (LysE YggA)
BH_RS14805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BH_RS14815	COG0534	Mate efflux family protein
BH_RS14820	COG2358	TRAP transporter, solute receptor (TAXI family
BH_RS14840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BH_RS14845	COG1509	lysine 2,3-aminomutase activity
BH_RS14865	COG2358	TRAP transporter, solute receptor (TAXI family
BH_RS14870	COG2204	response regulator
BH_RS14875	COG3852	Histidine kinase
BH_RS14890	COG0778	Nitroreductase
BH_RS14895	COG1703	isobutyryl-CoA mutase activity
BH_RS14900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BH_RS14900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BH_RS14905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BH_RS14910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BH_RS14915	COG1309	transcriptional regulator
BH_RS14940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BH_RS14950	COG3328	transposase activity
BH_RS14960	COG2201	protein-glutamate methylesterase activity
BH_RS14965	COG0835	chemotaxis
BH_RS14970	COG2198	Histidine kinase
BH_RS14970	COG0643	Histidine kinase
BH_RS14975	COG5001	Diguanylate cyclase
BH_RS14975	COG3300	MHYT domain
BH_RS14990	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BH_RS15000	COG3639	organic phosphonate transmembrane transporter activity
BH_RS15015	COG1074	ATP-dependent DNA helicase activity
BH_RS15020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BH_RS15040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BH_RS15045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BH_RS15065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BH_RS15070	COG0581	inorganic phosphate transmembrane transporter activity
BH_RS15075	COG0573	inorganic phosphate transmembrane transporter activity
BH_RS15080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BH_RS15085	COG0492	ferredoxin-NADP+ reductase activity
BH_RS15090	COG0640	Transcriptional regulator
BH_RS15100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BH_RS15105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BH_RS15110	COG0640	Transcriptional regulator
BH_RS15115	COG0110	maltose O-acetyltransferase activity
BH_RS15120	COG1234	tRNA 3'-trailer cleavage
BH_RS15135	COG4948	Mandelate Racemase Muconate Lactonizing
BH_RS15145	COG1228	amidohydrolase
BH_RS15150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BH_RS15155	COG2868	ribosomal protein
BH_RS15160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BH_RS15170	COG1530	ribonuclease E activity
BH_RS15175	COG1994	Peptidase M50
BH_RS15180	COG0739	heme binding
BH_RS15185	COG0746	molybdenum cofactor guanylyltransferase activity
BH_RS15195	COG0314	molybdopterin synthase activity
BH_RS15200	COG1763	Mo-molybdopterin cofactor biosynthetic process
BH_RS15205	COG0303	'Molybdopterin
BH_RS15210	COG0521	Mo-molybdopterin cofactor biosynthetic process
BH_RS15215	COG0315	cyclic pyranopterin monophosphate synthase activity
BH_RS15225	COG0693	protein deglycase activity
BH_RS15230	COG0747	negative chemotaxis
BH_RS15235	COG2894	cell division
BH_RS15240	COG0850	regulation of cytokinetic process
BH_RS15245	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BH_RS15250	COG1792	Involved in formation and maintenance of cell shape
BH_RS15255	COG1077	Cell shape determining protein MreB Mrl
BH_RS15260	COG2003	Belongs to the UPF0758 family
BH_RS15265	COG0424	maF-like protein
BH_RS15275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BH_RS15280	COG3706	GGDEF domain
BH_RS15285	COG0285	dihydrofolate synthase activity
BH_RS15295	COG0525	valine-tRNA ligase activity
BH_RS15315	COG1388	LysM domain
BH_RS15315	COG1388	LysM domain
BH_RS15320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BH_RS15325	COG0113	porphobilinogen synthase activity
BH_RS15330	COG1587	Uroporphyrinogen-III synthase
BH_RS15335	COG0181	hydroxymethylbilane synthase activity
BH_RS15340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BH_RS15345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BH_RS15350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BH_RS15355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BH_RS15360	COG0470	DNA polymerase III
BH_RS15360	COG1067	ATP-dependent peptidase activity
BH_RS15365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BH_RS15370	COG0544	peptidyl-prolyl cis-trans isomerase activity
BH_RS15375	COG0457	Tetratricopeptide repeat
BH_RS15375	COG1477	protein flavinylation
BH_RS15380	COG0066	3-isopropylmalate dehydratase activity
BH_RS15385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BH_RS15390	COG0473	3-isopropylmalate dehydrogenase activity
BH_RS15395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BH_RS15400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BH_RS15405	COG0440	acetolactate synthase activity
BH_RS15415	COG0129	dihydroxy-acid dehydratase activity
BH_RS15445	COG0622	Phosphoesterase
BH_RS15450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BH_RS15455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BH_RS15460	COG5401	PFAM Sporulation and spore germination
BH_RS15470	COG1846	Transcriptional regulator
BH_RS15475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BH_RS15480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BH_RS15485	COG2197	response regulator
BH_RS15490	COG0456	acetyltransferase
BH_RS15495	COG1846	Transcriptional regulator
BH_RS15500	COG2364	Membrane
BH_RS15520	COG0251	oxidation-reduction process
BH_RS15540	COG1051	belongs to the nudix hydrolase family
BH_RS15550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BH_RS15555	COG1053	succinate dehydrogenase
BH_RS15560	COG2009	succinate dehydrogenase
BH_RS15565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BH_RS15570	COG1719	4-vinyl reductase, 4VR
BH_RS15580	COG0322	excinuclease ABC activity
BH_RS15585	COG3118	belongs to the thioredoxin family
BH_RS15590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BH_RS15595	COG2086	electron transfer activity
BH_RS15600	COG1024	Enoyl-CoA hydratase
BH_RS15605	COG1309	transcriptional regulator
BH_RS15610	COG0318	PFAM AMP-dependent synthetase and ligase
BH_RS15615	COG0318	PFAM AMP-dependent synthetase and ligase
BH_RS15620	COG3766	membrane
BH_RS15625	COG1193	negative regulation of DNA recombination
BH_RS15630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BH_RS15630	COG1796	DNA polymerase
BH_RS15635	COG1286	toxin biosynthetic process
BH_RS15640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BH_RS15645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BH_RS15645	COG0072	phenylalanine-tRNA ligase activity
BH_RS15650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BH_RS15655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BH_RS15670	COG2318	DinB family
BH_RS15675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BH_RS15685	COG0740	serine-type endopeptidase activity
BH_RS15700	COG0577	efflux transmembrane transporter activity
BH_RS15705	COG1136	(ABC) transporter
BH_RS15720	COG1959	2 iron, 2 sulfur cluster binding
BH_RS15740	COG4208	sulfate ABC transporter
BH_RS15745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BH_RS15755	COG1363	Peptidase, m42
BH_RS15775	COG3326	Membrane
BH_RS15785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BH_RS15790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BH_RS15795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BH_RS15800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BH_RS15810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BH_RS15815	COG1484	DNA-dependent DNA replication
BH_RS15820	COG3611	Membrane attachment protein
BH_RS15825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BH_RS15835	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BH_RS15840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BH_RS15845	COG0237	dephospho-CoA kinase activity
BH_RS15850	COG1971	Probably functions as a manganese efflux pump
BH_RS15855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BH_RS15860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BH_RS15860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BH_RS15865	COG0330	HflC and HflK could
BH_RS15870	COG0330	HflC and HflK could
BH_RS15875	COG5002	protein histidine kinase activity
BH_RS15880	COG0745	RESPONSE REGULATOR receiver
BH_RS15885	COG0039	L-malate dehydrogenase activity
BH_RS15890	COG0538	isocitrate dehydrogenase activity
BH_RS15895	COG0372	Belongs to the citrate synthase family
BH_RS15900	COG2707	UPF0756 membrane protein
BH_RS15905	COG3030	protein affecting phage T7 exclusion by the F plasmid
BH_RS15915	COG0205	6-phosphofructokinase activity
BH_RS15920	COG0825	malonyl-CoA metabolic process
BH_RS15925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BH_RS15930	COG2186	Transcriptional regulator
BH_RS15935	COG0281	malic enzyme
BH_RS15940	COG0587	DNA-directed DNA polymerase activity
BH_RS15960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BH_RS15970	COG4109	DRTGG domain
BH_RS15985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BH_RS15990	COG0006	proline dipeptidase activity
BH_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS16010	COG0589	response to stress
BH_RS16025	COG0165	Argininosuccinate lyase
BH_RS16030	COG0137	argininosuccinate synthase activity
BH_RS16040	COG2217	Heavy metal translocating P-type atpase
BH_RS16045	COG3481	metal-dependent phosphohydrolase, HD sub domain
BH_RS16050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BH_RS16055	COG0827	DNA restriction-modification system
BH_RS16060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BH_RS16065	COG3874	Sporulation protein YtfJ
BH_RS16075	COG1714	RDD family
BH_RS16080	COG0616	signal peptide processing
BH_RS16085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BH_RS16090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BH_RS16095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BH_RS16105	COG0301	tRNA thio-modification
BH_RS16110	COG1104	cysteine desulfurase activity
BH_RS16115	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BH_RS16120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BH_RS16125	COG1309	transcriptional regulator
BH_RS16130	COG1956	GAF domain-containing protein
BH_RS16135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BH_RS16145	COG2211	Major facilitator Superfamily
BH_RS16170	COG1595	DNA-templated transcription, initiation
BH_RS16210	COG2239	Acts as a magnesium transporter
BH_RS16215	COG1285	pathogenesis
BH_RS16225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BH_RS16235	COG1609	Transcriptional regulator
BH_RS16265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BH_RS16270	COG0454	-acetyltransferase
BH_RS16275	COG0517	IMP dehydrogenase activity
BH_RS16280	COG0123	including yeast histone deacetylase and acetoin utilization protein
BH_RS16285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BH_RS16295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BH_RS16305	COG1605	Chorismate mutase
BH_RS16305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BH_RS16310	COG0849	cell division
BH_RS16315	COG4980	gas vesicle protein
BH_RS16325	COG2309	aminopeptidase activity
BH_RS16335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BH_RS16345	COG1674	ftsk spoiiie
BH_RS16350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BH_RS16355	COG4848	Belongs to the UPF0354 family
BH_RS16360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BH_RS16375	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BH_RS16380	COG1363	Peptidase, m42
BH_RS16385	COG5584	Small secreted protein
BH_RS16390	COG0217	transcriptional regulatory protein
BH_RS16395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BH_RS16400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BH_RS16410	COG0510	thiamine kinase activity
BH_RS16415	COG1523	belongs to the glycosyl hydrolase 13 family
BH_RS16420	COG0788	formyltetrahydrofolate deformylase activity
BH_RS16435	COG1346	cytolysis
BH_RS16440	COG1380	Effector of murein hydrolase LrgA
BH_RS16450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BH_RS16455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BH_RS16460	COG1349	DNA-binding transcription factor activity
BH_RS16465	COG1187	pseudouridine synthase activity
BH_RS16475	COG0772	Belongs to the SEDS family
BH_RS16480	COG0772	Belongs to the SEDS family
BH_RS16485	COG2244	polysaccharide biosynthetic process
BH_RS16495	COG2081	HI0933 family
BH_RS16505	COG0495	leucyl-tRNA aminoacylation
BH_RS16510	COG2814	Major facilitator Superfamily
BH_RS16515	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BH_RS16520	COG1242	4 iron, 4 sulfur cluster binding
BH_RS16525	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BH_RS16530	COG0288	reversible hydration of carbon dioxide
BH_RS16540	COG2267	carboxylic ester hydrolase activity
BH_RS16545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BH_RS16560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS16565	COG1120	ATPase activity
BH_RS16570	COG2329	Antibiotic biosynthesis monooxygenase
BH_RS16575	COG4509	Sortase family
BH_RS16595	COG5386	Cell surface protein
BH_RS16600	COG5386	Cell surface protein
BH_RS16605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BH_RS16615	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BH_RS16620	COG1733	regulation of RNA biosynthetic process
BH_RS16625	COG2259	Doxx family
BH_RS16630	COG2514	catechol 2,3-dioxygenase activity
BH_RS16635	COG1506	peptidase
BH_RS16640	COG0494	nUDIX hydrolase
BH_RS16645	COG2814	Major facilitator Superfamily
BH_RS16655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BH_RS16660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BH_RS16670	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS16680	COG2814	Major facilitator Superfamily
BH_RS16695	COG0431	NADPH-dependent FMN reductase
BH_RS16700	COG3584	3D domain protein
BH_RS16700	COG3583	domain protein
BH_RS16710	COG2188	Transcriptional regulator
BH_RS16720	COG4821	SIS domain
BH_RS16725	COG3458	cephalosporin-C deacetylase activity
BH_RS16730	COG0471	metal ion transport
BH_RS16735	COG4149	molybdate abc transporter
BH_RS16740	COG0725	ABC transporter, periplasmic molybdate-binding protein
BH_RS16765	COG1999	signal sequence binding
BH_RS16790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BH_RS16805	COG0166	Belongs to the GPI family
BH_RS16810	COG1979	alcohol dehydrogenase
BH_RS16815	COG2155	Conserved Protein
BH_RS16825	COG1098	S1 RNA binding domain
BH_RS16835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BH_RS16840	COG0436	Aminotransferase
BH_RS16845	COG1522	sequence-specific DNA binding
BH_RS16850	COG5506	Protein of unknown function (DUF1694)
BH_RS16855	COG1854	S-ribosylhomocysteine lyase activity
BH_RS16865	COG1295	ribonuclease BN
BH_RS16870	COG0776	regulation of translation
BH_RS16875	COG1714	RDD family
BH_RS16880	COG1268	BioY protein
BH_RS16885	COG2056	Na+-H+ antiporter family
BH_RS16905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BH_RS16910	COG1088	dTDP-glucose 4,6-dehydratase activity
BH_RS16920	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BH_RS16950	COG0613	PHP domain protein
BH_RS16955	COG0463	Glycosyl transferase, family 2
BH_RS16975	COG0438	transferase activity, transferring glycosyl groups
BH_RS16985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BH_RS17005	COG0471	metal ion transport
BH_RS17005	COG3273	potassium ion transport
BH_RS17010	COG0529	Catalyzes the synthesis of activated sulfate
BH_RS17020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BH_RS17030	COG0768	penicillin binding
BH_RS17035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BH_RS17040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BH_RS17045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BH_RS17050	COG2376	Dihydroxyacetone kinase
BH_RS17055	COG1309	transcriptional regulator
BH_RS17060	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BH_RS17065	COG1461	Dihydroxyacetone kinase
BH_RS17070	COG2376	Dihydroxyacetone kinase
BH_RS17075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BH_RS17085	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BH_RS17090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BH_RS17095	COG3584	3D domain protein
BH_RS17105	COG1252	NADH dehydrogenase
BH_RS17110	COG0492	ferredoxin-NADP+ reductase activity
BH_RS17120	COG0316	Belongs to the HesB IscA family
BH_RS17130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BH_RS17135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BH_RS17145	COG4844	belongs to the
BH_RS17150	COG1252	NADH dehydrogenase
BH_RS17155	COG4837	Protein of unknown function (DUF1462)
BH_RS17160	COG2801	Transposase and inactivated derivatives
BH_RS17170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BH_RS17175	COG0083	homoserine kinase activity
BH_RS17180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BH_RS17185	COG0460	homoserine dehydrogenase
BH_RS17190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BH_RS17195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BH_RS17200	COG2205	protein histidine kinase activity
BH_RS17205	COG0745	RESPONSE REGULATOR receiver
BH_RS17210	COG2311	Membrane
BH_RS17215	COG0647	UMP catabolic process
BH_RS17225	COG2445	Protein of unknown function DUF86
BH_RS17230	COG1494	fructose-1,6-bisphosphatase
BH_RS17240	COG4470	Protein conserved in bacteria
BH_RS17250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BH_RS17255	COG0739	heme binding
BH_RS17260	COG0733	neurotransmitter:sodium symporter activity
BH_RS17265	COG4214	carbohydrate transport
BH_RS17270	COG1129	ABC transporter
BH_RS17275	COG4213	ABC transporter substrate-binding protein
BH_RS17280	COG4977	sequence-specific DNA binding
BH_RS17280	COG1917	Cupin 2, conserved barrel domain protein
BH_RS17285	COG2801	Transposase and inactivated derivatives
BH_RS17295	COG2197	response regulator
BH_RS17300	COG2972	Histidine kinase
BH_RS17310	COG1757	Na H antiporter
BH_RS17315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BH_RS17320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BH_RS17325	COG3377	Domain of unknown function (DUF1805)
BH_RS17330	COG0737	Belongs to the 5'-nucleotidase family
BH_RS17335	COG0730	response to heat
BH_RS17340	COG1801	Protein of unknown function DUF72
BH_RS17345	COG3328	transposase activity
BH_RS17380	COG0719	Fe-S assembly protein
BH_RS17385	COG0822	iron-sulfur transferase activity
BH_RS17395	COG0719	Fe-S assembly protein
BH_RS17400	COG0396	ATPase activity
BH_RS17410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BH_RS17415	COG4512	PFAM Accessory gene regulator B
BH_RS17435	COG1464	Belongs to the NlpA lipoprotein family
BH_RS17440	COG2011	ABC-type metal ion transport system permease component
BH_RS17445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BH_RS17460	COG0509	glycine decarboxylation via glycine cleavage system
BH_RS17465	COG1393	Belongs to the ArsC family
BH_RS17470	COG1960	acyl-CoA dehydrogenase activity
BH_RS17475	COG0183	Belongs to the thiolase family
BH_RS17480	COG1250	3-hydroxyacyl-CoA dehydrogenase
BH_RS17480	COG1024	Enoyl-CoA hydratase
BH_RS17490	COG5577	PFAM Coat F domain
BH_RS17505	COG1131	(ABC) transporter
BH_RS17515	COG1280	lysine exporter protein (LysE YggA)
BH_RS17520	COG0789	Transcriptional regulator
BH_RS17520	COG4978	Transcriptional regulator
BH_RS17530	COG0432	Pfam Uncharacterised protein family UPF0047
BH_RS17540	COG2268	Band 7 protein
BH_RS17560	COG2826	transposase and inactivated derivatives, IS30 family
BH_RS17575	COG1136	(ABC) transporter
BH_RS17580	COG2207	Transcriptional regulator
BH_RS17600	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS17730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BH_RS17765	COG1484	DNA-dependent DNA replication
BH_RS17780	COG3723	Recombinational DNA repair protein, rece pathway
BH_RS17785	COG5377	YqaJ viral recombinase family
BH_RS17810	COG1396	sequence-specific DNA binding
BH_RS17820	COG4974	Belongs to the 'phage' integrase family
BH_RS17825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BH_RS17830	COG0557	exoribonuclease II activity
BH_RS17835	COG1647	Serine aminopeptidase, S33
BH_RS17840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BH_RS17845	COG0148	phosphopyruvate hydratase activity
BH_RS17850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BH_RS17855	COG0149	triose-phosphate isomerase activity
BH_RS17860	COG0126	phosphoglycerate kinase activity
BH_RS17865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BH_RS17880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BH_RS17885	COG0740	serine-type endopeptidase activity
BH_RS17895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BH_RS17900	COG1481	regulation of sporulation
BH_RS17905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BH_RS17910	COG1660	Displays ATPase and GTPase activities
BH_RS17915	COG1051	belongs to the nudix hydrolase family
BH_RS17920	COG0492	ferredoxin-NADP+ reductase activity
BH_RS17925	COG0457	Tetratricopeptide repeat
BH_RS17935	COG1263	PTS System
BH_RS17935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BH_RS17940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BH_RS17950	COG1737	Transcriptional regulator
BH_RS17955	COG0140	phosphoribosyl-ATP diphosphatase activity
BH_RS17955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BH_RS17960	COG0107	imidazoleglycerol-phosphate synthase activity
BH_RS17965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BH_RS17970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BH_RS17975	COG0131	Imidazoleglycerol-phosphate dehydratase
BH_RS17980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BH_RS17985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BH_RS17990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BH_RS18000	COG0110	maltose O-acetyltransferase activity
BH_RS18005	COG0546	phosphoglycolate phosphatase activity
BH_RS18010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BH_RS18015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BH_RS18020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BH_RS18025	COG1950	PFAM Membrane protein of
BH_RS18030	COG1983	PspC domain protein
BH_RS18035	COG3595	metallopeptidase activity
BH_RS18040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BH_RS18045	COG0556	nucleotide-excision repair
BH_RS18050	COG3764	Sortase (surface protein transpeptidase)
BH_RS18060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BH_RS18065	COG3409	Peptidoglycan-binding domain 1 protein
BH_RS18065	COG0793	Belongs to the peptidase S41A family
BH_RS18070	COG0739	heme binding
BH_RS18075	COG2177	Part of the ABC transporter FtsEX involved in
BH_RS18085	COG4654	Cytochrome c, class I
BH_RS18090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BH_RS18095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BH_RS18100	COG0653	protein targeting
BH_RS18110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BH_RS18120	COG1278	Cold shock
BH_RS18135	COG1516	flagellar protein fliS
BH_RS18140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BH_RS18145	COG1334	flagellar protein FlaG
BH_RS18150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BH_RS18155	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BH_RS18160	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BH_RS18170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BH_RS18175	COG1256	bacterial-type flagellum assembly
BH_RS18175	COG4786	Flagellar basal body rod
BH_RS18195	COG1040	competence protein
BH_RS18200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BH_RS18205	COG1307	EDD domain protein, DegV family
BH_RS18225	COG1739	Uncharacterized protein family UPF0029
BH_RS18230	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BH_RS18245	COG3708	Transcriptional regulator
BH_RS18245	COG2207	Transcriptional regulator
BH_RS18255	COG0747	negative chemotaxis
BH_RS18265	COG0601	transmembrane transport
BH_RS18270	COG4608	Belongs to the ABC transporter superfamily
BH_RS18280	COG1522	sequence-specific DNA binding
BH_RS18285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BH_RS18290	COG0601	transmembrane transport
BH_RS18295	COG0747	negative chemotaxis
BH_RS18300	COG4608	Belongs to the ABC transporter superfamily
BH_RS18305	COG0444	Belongs to the ABC transporter superfamily
BH_RS18310	COG1316	TRANSCRIPTIONal
BH_RS18315	COG2385	sporulation resulting in formation of a cellular spore
BH_RS18320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BH_RS18330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BH_RS18335	COG1181	Belongs to the D-alanine--D-alanine ligase family
BH_RS18335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BH_RS18355	COG1215	transferase activity, transferring glycosyl groups
BH_RS18360	COG1216	Glycosyl transferase, family 2
BH_RS18365	COG1134	teichoic acid transport
BH_RS18370	COG1682	transport, permease protein
BH_RS18375	COG1215	transferase activity, transferring glycosyl groups
BH_RS18385	COG0438	transferase activity, transferring glycosyl groups
BH_RS18390	COG3328	transposase activity
BH_RS18405	COG4464	protein tyrosine phosphatase activity
BH_RS18410	COG0489	protein tyrosine kinase activity
BH_RS18415	COG3944	biosynthesis protein
BH_RS18420	COG1316	TRANSCRIPTIONal
BH_RS18425	COG1388	LysM domain
BH_RS18425	COG0791	NLP P60 protein
BH_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BH_RS18435	COG1136	(ABC) transporter
BH_RS18440	COG0577	efflux transmembrane transporter activity
BH_RS18455	COG2072	flavoprotein involved in K transport
BH_RS18460	COG2972	Histidine kinase
BH_RS18465	COG4753	response regulator
BH_RS18465	COG2207	Transcriptional regulator
BH_RS18470	COG1653	transport
BH_RS18475	COG1175	transmembrane transport
BH_RS18480	COG0395	ABC-type sugar transport system, permease component
BH_RS18485	COG3507	Belongs to the glycosyl hydrolase 43 family
BH_RS18490	COG5578	integral membrane protein
BH_RS18495	COG2318	DinB family
BH_RS18515	COG0395	ABC-type sugar transport system, permease component
BH_RS18520	COG1175	transmembrane transport
BH_RS18525	COG1653	transport
BH_RS18535	COG1609	Transcriptional regulator
BH_RS18540	COG2311	Membrane
BH_RS18550	COG0457	Tetratricopeptide repeat
BH_RS18555	COG1523	belongs to the glycosyl hydrolase 13 family
BH_RS18575	COG0584	glycerophosphoryl diester phosphodiesterase
BH_RS18610	COG5444	nuclease activity
BH_RS18615	COG0457	Tetratricopeptide repeat
BH_RS18655	COG1216	Glycosyl transferase, family 2
BH_RS18655	COG0463	Glycosyl transferase, family 2
BH_RS18660	COG1216	Glycosyl transferase, family 2
BH_RS18675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BH_RS18685	COG2336	PFAM SpoVT AbrB
BH_RS18690	COG2337	Toxic component of a toxin-antitoxin (TA) module
BH_RS18695	COG0800	Aldolase
BH_RS18700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BH_RS18705	COG1414	Transcriptional regulator
BH_RS18715	COG1609	Transcriptional regulator
BH_RS18720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BH_RS18725	COG1869	D-ribose catabolic process
BH_RS18730	COG1129	ABC transporter
BH_RS18735	COG1172	Belongs to the binding-protein-dependent transport system permease family
BH_RS18740	COG1879	ABC-type sugar transport system periplasmic component
BH_RS18755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BH_RS18765	COG4786	Flagellar basal body rod
BH_RS18770	COG4786	Flagellar basal body rod
BH_RS18775	COG1077	Cell shape determining protein MreB Mrl
BH_RS18780	COG1609	Transcriptional regulator
BH_RS18785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BH_RS18785	COG1199	ATP-dependent helicase activity
BH_RS18790	COG0517	IMP dehydrogenase activity
BH_RS18790	COG0617	tRNA 3'-terminal CCA addition
BH_RS18790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BH_RS18795	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BH_RS18810	COG0739	heme binding
BH_RS18820	COG2385	sporulation resulting in formation of a cellular spore
BH_RS18825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BH_RS18835	COG4836	Membrane
BH_RS18845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BH_RS18850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BH_RS18855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BH_RS18860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BH_RS18865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BH_RS18870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BH_RS18875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BH_RS18880	COG0356	it plays a direct role in the translocation of protons across the membrane
BH_RS18895	COG1404	Belongs to the peptidase S8 family
BH_RS18900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BH_RS18905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BH_RS18910	COG4475	Protein of unknown function (DUF436)
BH_RS18915	COG0698	ribose 5-phosphate isomerase
BH_RS18920	COG0840	transmembrane signaling receptor activity
BH_RS18930	COG1971	Probably functions as a manganese efflux pump
BH_RS18935	COG0009	L-threonylcarbamoyladenylate synthase
BH_RS18955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BH_RS18965	COG1335	isochorismatase
BH_RS18975	COG1435	thymidine kinase activity
BH_RS18980	COG0254	rRNA binding
BH_RS18985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BH_RS18990	COG1494	fructose-1,6-bisphosphatase
BH_RS18995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BH_RS19000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BH_RS19005	COG0191	fructose-bisphosphate aldolase activity
BH_RS19010	COG2204	response regulator
BH_RS19020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS19025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BH_RS19030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BH_RS19040	COG0504	CTP synthase activity
BH_RS19045	COG3343	RNA polymerase activity
BH_RS19055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BH_RS19055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BH_RS19055	COG1703	isobutyryl-CoA mutase activity
BH_RS19065	COG1960	acyl-CoA dehydrogenase activity
BH_RS19070	COG1960	acyl-CoA dehydrogenase activity
BH_RS19075	COG1250	3-hydroxyacyl-CoA dehydrogenase
BH_RS19080	COG0183	Belongs to the thiolase family
BH_RS19085	COG0247	lactate metabolic process
BH_RS19085	COG2181	nitrate reductase activity
BH_RS19090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BH_RS19095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BH_RS19100	COG2267	carboxylic ester hydrolase activity
BH_RS19110	COG2839	Protein conserved in bacteria
BH_RS19115	COG0018	arginyl-trna synthetase
BH_RS19130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BH_RS19135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BH_RS19145	COG1942	4-Oxalocrotonate Tautomerase
BH_RS19160	COG3465	dGTPase activity
BH_RS19165	COG1078	dGTPase activity
BH_RS19175	COG1301	dicarboxylic acid transport
BH_RS19180	COG4844	belongs to the
BH_RS19185	COG0095	Lipoate-protein ligase
BH_RS19190	COG0280	phosphate acetyltransferase
BH_RS19195	COG1024	Enoyl-CoA hydratase
BH_RS19200	COG3253	May function as heme-dependent peroxidase
BH_RS19205	COG3773	Cell wall hydrolase
BH_RS19215	COG2363	Small membrane protein
BH_RS19220	COG0456	acetyltransferase
BH_RS19235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BH_RS19245	COG0004	ammonium transporteR
BH_RS19255	COG2368	4-hydroxyphenylacetate
BH_RS19265	COG4565	transcriptional regulatory protein
BH_RS19270	COG3290	protein histidine kinase activity
BH_RS19280	COG2972	Histidine kinase
BH_RS19285	COG2207	Transcriptional regulator
BH_RS19285	COG4753	response regulator
BH_RS19305	COG1175	transmembrane transport
BH_RS19310	COG0395	ABC-type sugar transport system, permease component
BH_RS19320	COG0656	L-ascorbic acid biosynthetic process
BH_RS19325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BH_RS19330	COG0246	Mannitol dehydrogenase
BH_RS19335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BH_RS19340	COG3711	transcriptional antiterminator
BH_RS19345	COG2213	PTS system mannitol-specific
BH_RS19370	COG0778	Nitroreductase
BH_RS19375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BH_RS19380	COG2234	aminopeptidase activity
BH_RS19390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BH_RS19400	COG2962	Rard protein
BH_RS19410	COG0366	Alpha amylase catalytic
BH_RS19420	COG5609	conserved protein (DUF2294)
BH_RS19425	COG0723	plastoquinol--plastocyanin reductase activity
BH_RS19425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BH_RS19435	COG0028	Belongs to the TPP enzyme family
BH_RS19450	COG5582	Belongs to the UPF0302 family
BH_RS19455	COG1522	sequence-specific DNA binding
BH_RS19470	COG2814	Major facilitator Superfamily
BH_RS19485	COG2329	Antibiotic biosynthesis monooxygenase
BH_RS19490	COG1733	regulation of RNA biosynthetic process
BH_RS19495	COG2249	NAD(P)H dehydrogenase (quinone) activity
BH_RS19500	COG2814	Major facilitator Superfamily
BH_RS19510	COG5577	PFAM Coat F domain
BH_RS19525	COG1132	(ABC) transporter
BH_RS19540	COG1131	(ABC) transporter
BH_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
BH_RS19555	COG2610	gluconate transmembrane transporter activity
BH_RS19565	COG3829	transcription factor binding
BH_RS19565	COG3290	protein histidine kinase activity
BH_RS19570	COG0840	transmembrane signaling receptor activity
BH_RS19585	COG0840	transmembrane signaling receptor activity
BH_RS19595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BH_RS19600	COG0805	protein transport
BH_RS19605	COG0156	8-amino-7-oxononanoate synthase activity
BH_RS19610	COG0596	Alpha beta hydrolase
BH_RS19615	COG4106	trans-aconitate 2-methyltransferase activity
BH_RS19625	COG0745	RESPONSE REGULATOR receiver
BH_RS19630	COG0642	Histidine kinase
BH_RS19635	COG1136	(ABC) transporter
BH_RS19640	COG0577	efflux transmembrane transporter activity
BH_RS19645	COG0840	transmembrane signaling receptor activity
BH_RS19650	COG1482	cell wall glycoprotein biosynthetic process
BH_RS19655	COG2188	Transcriptional regulator
BH_RS19660	COG2723	6-phospho-beta-galactosidase activity
BH_RS19665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BH_RS19670	COG1447	Phosphotransferase system cellobiose-specific component IIA
BH_RS19675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BH_RS19685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BH_RS19690	COG2079	MmgE PrpD family protein
BH_RS19695	COG0372	Belongs to the citrate synthase family
BH_RS19700	COG0583	DNA-binding transcription factor activity
BH_RS19705	COG1115	amino acid carrier protein
BH_RS19710	COG4989	oxidoreductase activity
BH_RS19725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BH_RS19755	COG1329	Transcriptional regulator
BH_RS19760	COG1620	l-lactate permease
BH_RS19765	COG0039	L-malate dehydrogenase activity
BH_RS19775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BH_RS19780	COG1012	belongs to the aldehyde dehydrogenase family
BH_RS19790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BH_RS19795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BH_RS19800	COG3829	transcription factor binding
BH_RS19805	COG1757	Na H antiporter
BH_RS19810	COG3314	Sporulation integral membrane protein YlbJ
BH_RS19820	COG1063	alcohol dehydrogenase
BH_RS19825	COG2826	transposase and inactivated derivatives, IS30 family
BH_RS19850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BH_RS19875	COG0579	oxidoreductase
BH_RS19880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BH_RS19890	COG2755	lipolytic protein G-D-S-L family
BH_RS19925	COG4988	ABC transporter
BH_RS19930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BH_RS19935	COG1294	oxidase, subunit
BH_RS19940	COG1271	oxidase subunit
BH_RS19980	COG2002	toxin-antitoxin pair type II binding
BH_RS19985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BH_RS20090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BH_RS20115	COG0457	Tetratricopeptide repeat
BH_RS20155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BH_RS20160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BH_RS20165	COG4853	Protein conserved in bacteria
BH_RS20170	COG4863	YycH protein
BH_RS20175	COG5002	protein histidine kinase activity
BH_RS20180	COG0745	RESPONSE REGULATOR receiver
BH_RS20210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BH_RS20215	COG0305	Participates in initiation and elongation during chromosome replication
BH_RS20220	COG0359	binds to the 23S rRNA
BH_RS20225	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BH_RS20230	COG4241	membrane
BH_RS20235	COG1115	amino acid carrier protein
BH_RS20260	COG0582	viral genome integration into host DNA
BH_RS20285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BH_RS20305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BH_RS20310	COG0629	single-stranded DNA binding
BH_RS20315	COG0360	Binds together with S18 to 16S ribosomal RNA
BH_RS20320	COG0012	GTP binding
BH_RS20325	COG4481	Protein conserved in bacteria
BH_RS20330	COG3949	Membrane
BH_RS20340	COG1811	Na channel or pump
BH_RS20350	COG1475	DNA binding
BH_RS20355	COG1192	Involved in chromosome partitioning
BH_RS20360	COG1475	DNA binding
BH_RS20365	COG0357	Ribosomal RNA small subunit methyltransferase G
BH_RS20370	COG0445	tRNA wobble uridine modification
BH_RS20375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BH_RS20380	COG1847	R3H domain protein
BH_RS20385	COG0706	membrane insertase activity
BH_RS20390	COG0594	ribonuclease P activity
BH_RS20455	COG2181	nitrate reductase activity
BH_RS20470	COG3212	peptidase
BH_RS20475	COG1404	Belongs to the peptidase S8 family
BH_RS20480	COG0383	alpha-mannosidase activity
BH_RS20490	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS20500	COG4585	Histidine kinase
BH_RS20505	COG3401	FG-GAP repeat protein
BH_RS20515	COG1396	sequence-specific DNA binding
BH_RS20520	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS20530	COG0523	cobalamin synthesis protein
BH_RS20535	COG0617	tRNA 3'-terminal CCA addition
BH_RS20555	COG4977	sequence-specific DNA binding
BH_RS20565	COG0312	modulator of DNA gyrase
BH_RS20575	COG2203	Gaf domain
BH_RS20575	COG4585	Histidine kinase
BH_RS20590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BH_RS20670	COG2247	cell wall binding repeat
BH_RS20670	COG0860	N-Acetylmuramoyl-L-alanine amidase
BH_RS20690	COG0726	polysaccharide deacetylase
BH_RS20715	COG0230	Belongs to the bacterial ribosomal protein bL34 family