locus-tag	class	description
HT135_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HT135_RS00010	COG0592	DNA-directed DNA polymerase activity
HT135_RS00015	COG2501	S4 domain
HT135_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HT135_RS00030	COG0187	DNA topoisomerase II activity
HT135_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT135_RS00075	COG0516	GMP reductase activity
HT135_RS00075	COG0517	IMP dehydrogenase activity
HT135_RS00080	COG1686	Belongs to the peptidase S11 family
HT135_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HT135_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HT135_RS00105	COG1428	Deoxynucleoside kinase
HT135_RS00110	COG1428	Deoxynucleoside kinase
HT135_RS00115	COG1388	LysM domain
HT135_RS00115	COG3858	chitin binding
HT135_RS00120	COG1335	isochorismatase
HT135_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HT135_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HT135_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HT135_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HT135_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HT135_RS00195	COG3853	Toxic anion resistance protein (TelA)
HT135_RS00200	COG1982	Orn Lys Arg decarboxylase major
HT135_RS00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT135_RS00210	COG3870	Protein conserved in bacteria
HT135_RS00215	COG1728	Protein conserved in bacteria
HT135_RS00220	COG0470	DNA polymerase III
HT135_RS00225	COG1774	PSP1 C-terminal conserved region
HT135_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HT135_RS00240	COG2827	Endonuclease containing a URI domain
HT135_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HT135_RS00250	COG2002	toxin-antitoxin pair type II binding
HT135_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_RS00260	COG0084	hydrolase, TatD family'
HT135_RS00265	COG3583	domain protein
HT135_RS00265	COG3584	3D domain protein
HT135_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HT135_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HT135_RS00285	COG4466	Protein conserved in bacteria
HT135_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HT135_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_RS00305	COG0251	oxidation-reduction process
HT135_RS00310	COG2088	sporulation resulting in formation of a cellular spore
HT135_RS00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HT135_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HT135_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HT135_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
HT135_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HT135_RS00345	COG2002	toxin-antitoxin pair type II binding
HT135_RS00350	COG2244	polysaccharide biosynthetic process
HT135_RS00355	COG3956	TIGRFAM MazG family protein
HT135_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HT135_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HT135_RS00380	COG1098	S1 RNA binding domain
HT135_RS00395	COG2208	phosphoserine phosphatase activity
HT135_RS00400	COG2304	oxidoreductase activity
HT135_RS00405	COG0515	serine threonine protein kinase
HT135_RS00410	COG0037	tRNA processing
HT135_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HT135_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HT135_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HT135_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HT135_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT135_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT135_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HT135_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HT135_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HT135_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HT135_RS00475	COG1396	sequence-specific DNA binding
HT135_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT135_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HT135_RS00565	COG4463	regulation of RNA biosynthetic process
HT135_RS00570	COG3880	PFAM UvrB UvrC protein
HT135_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HT135_RS00580	COG0542	response to heat
HT135_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HT135_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HT135_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HT135_RS00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HT135_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HT135_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HT135_RS00615	COG1045	serine acetyltransferase
HT135_RS00620	COG0215	cysteine-tRNA ligase activity
HT135_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HT135_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT135_RS00635	COG3688	RNA-binding protein containing a PIN domain
HT135_RS00640	COG1595	DNA-templated transcription, initiation
HT135_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT135_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HT135_RS00665	COG0081	regulation of translation
HT135_RS00680	COG2813	Specifically methylates the guanine in position
HT135_RS00685	COG0085	RNA polymerase activity
HT135_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HT135_RS00695	COG1358	cellular component organization or biogenesis
HT135_RS00705	COG0049	tRNA binding
HT135_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HT135_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HT135_RS00720	COG0596	Alpha beta hydrolase
HT135_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HT135_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HT135_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HT135_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HT135_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HT135_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HT135_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HT135_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HT135_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HT135_RS00825	COG0200	Binds to the 23S rRNA
HT135_RS00830	COG0201	protein transport
HT135_RS00835	COG0563	adenylate kinase activity
HT135_RS00840	COG0024	Methionine aminopeptidase
HT135_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HT135_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HT135_RS00865	COG0202	RNA polymerase activity
HT135_RS00870	COG0203	ribosomal protein L17
HT135_RS00875	COG1122	ATPase activity
HT135_RS00880	COG1122	ATPase activity
HT135_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HT135_RS00890	COG0101	tRNA pseudouridine synthase activity
HT135_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HT135_RS00905	COG2226	methyltransferase
HT135_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS00920	COG0489	protein tyrosine kinase activity
HT135_RS00930	COG2194	sulfuric ester hydrolase activity
HT135_RS00935	COG0726	polysaccharide deacetylase
HT135_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
HT135_RS01020	COG0385	Bile acid
HT135_RS01025	COG2819	hydrolase of the alpha beta superfamily
HT135_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS01045	COG2207	Transcriptional regulator
HT135_RS01050	COG3876	Protein conserved in bacteria
HT135_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
HT135_RS01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS01065	COG1263	PTS System
HT135_RS01070	COG1737	Transcriptional regulator
HT135_RS01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HT135_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS01085	COG1683	Conserved Protein
HT135_RS01115	COG1595	DNA-templated transcription, initiation
HT135_RS01120	COG5662	AntiSigma factor
HT135_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HT135_RS01130	COG4856	YbbR-like protein
HT135_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HT135_RS01145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT135_RS01150	COG3002	Belongs to the UPF0753 family
HT135_RS01155	COG0288	reversible hydration of carbon dioxide
HT135_RS01165	COG5609	conserved protein (DUF2294)
HT135_RS01170	COG0640	Transcriptional regulator
HT135_RS01175	COG2814	Major facilitator Superfamily
HT135_RS01180	COG1413	lyase activity
HT135_RS01190	COG0596	Alpha beta hydrolase
HT135_RS01195	COG0745	RESPONSE REGULATOR receiver
HT135_RS01200	COG0642	Histidine kinase
HT135_RS01210	COG0515	serine threonine protein kinase
HT135_RS01225	COG1113	amino acid transport
HT135_RS01240	COG2602	Beta-lactamase
HT135_RS01245	COG2124	cytochrome p450
HT135_RS01255	COG0531	amino acid
HT135_RS01260	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_RS01265	COG2271	Major facilitator Superfamily
HT135_RS01275	COG0456	acetyltransferase
HT135_RS01275	COG1846	Transcriptional regulator
HT135_RS01280	COG2271	Major facilitator Superfamily
HT135_RS01290	COG0697	spore germination
HT135_RS01295	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS01295	COG2207	Transcriptional regulator
HT135_RS01300	COG0371	Dehydrogenase
HT135_RS01305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HT135_RS01310	COG3591	Belongs to the peptidase S1B family
HT135_RS01320	COG0596	Alpha beta hydrolase
HT135_RS01325	COG1183	phosphatidylcholine synthase activity
HT135_RS01330	COG0586	Pfam SNARE associated Golgi protein
HT135_RS01335	COG0688	phosphatidylethanolamine metabolic process
HT135_RS01345	COG2312	Erythromycin esterase
HT135_RS01355	COG1054	Belongs to the UPF0176 family
HT135_RS01360	COG1301	dicarboxylic acid transport
HT135_RS01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS01365	COG2190	(PTS) system
HT135_RS01365	COG1263	PTS System
HT135_RS01370	COG0363	glucosamine-6-phosphate deaminase activity
HT135_RS01375	COG2188	Transcriptional regulator
HT135_RS01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_RS01390	COG0833	amino acid
HT135_RS01395	COG2040	homocysteine
HT135_RS01400	COG1115	amino acid carrier protein
HT135_RS01405	COG2066	Belongs to the glutaminase family
HT135_RS01410	COG4191	Histidine kinase
HT135_RS01415	COG0784	Response regulator, receiver
HT135_RS01420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HT135_RS01425	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS01430	COG2271	Major facilitator Superfamily
HT135_RS01435	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_RS01440	COG2186	Transcriptional regulator
HT135_RS01445	COG2721	sulfolactate sulfo-lyase activity
HT135_RS01450	COG3173	Aminoglycoside phosphotransferase
HT135_RS01460	COG0745	RESPONSE REGULATOR receiver
HT135_RS01465	COG2205	protein histidine kinase activity
HT135_RS01470	COG1131	(ABC) transporter
HT135_RS01490	COG3773	Cell wall hydrolase
HT135_RS01495	COG2304	oxidoreductase activity
HT135_RS01505	COG3540	Alkaline phosphatase
HT135_RS01510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_RS01515	COG0805	protein transport
HT135_RS01520	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HT135_RS01525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HT135_RS01530	COG0477	Major facilitator Superfamily
HT135_RS01535	COG1309	transcriptional regulator
HT135_RS01540	COG0252	asparaginase activity
HT135_RS01545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HT135_RS01550	COG1714	RDD family
HT135_RS01555	COG3012	SEC-C Motif Domain Protein
HT135_RS01555	COG1405	negative regulation of cell septum assembly
HT135_RS01560	COG3290	protein histidine kinase activity
HT135_RS01565	COG3279	Response regulator of the LytR AlgR family
HT135_RS01570	COG4555	ABC transporter
HT135_RS01575	COG1668	transmembrane transport
HT135_RS01580	COG0667	Aldo Keto reductase
HT135_RS01595	COG1595	DNA-templated transcription, initiation
HT135_RS01600	COG1595	DNA-templated transcription, initiation
HT135_RS01605	COG1876	peptidase activity
HT135_RS01610	COG0457	Tetratricopeptide repeat
HT135_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS01620	COG0366	Alpha amylase catalytic
HT135_RS01625	COG0803	Belongs to the bacterial solute-binding protein 9 family
HT135_RS01630	COG1121	(ABC) transporter
HT135_RS01635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS01645	COG2310	stress, protein
HT135_RS01650	COG2310	stress, protein
HT135_RS01655	COG2310	stress, protein
HT135_RS01660	COG0861	Integral membrane protein TerC family
HT135_RS01675	COG1358	cellular component organization or biogenesis
HT135_RS01690	COG3853	Toxic anion resistance protein (TelA)
HT135_RS01695	COG0477	Major facilitator Superfamily
HT135_RS01700	COG2814	Major facilitator Superfamily
HT135_RS01705	COG0640	Transcriptional regulator
HT135_RS01710	COG0517	IMP dehydrogenase activity
HT135_RS01710	COG4175	Glycine betaine
HT135_RS01715	COG4176	ABC-type proline glycine betaine transport system permease component
HT135_RS01720	COG2113	Glycine betaine
HT135_RS01725	COG1473	amidohydrolase
HT135_RS01730	COG1288	antiporter activity
HT135_RS01740	COG0366	Alpha amylase catalytic
HT135_RS01745	COG0039	L-malate dehydrogenase activity
HT135_RS01750	COG1620	l-lactate permease
HT135_RS01760	COG2814	Major facilitator Superfamily
HT135_RS01765	COG1846	Transcriptional regulator
HT135_RS01770	COG1280	lysine exporter protein (LysE YggA)
HT135_RS01775	COG3403	YqcI/YcgG family
HT135_RS01780	COG1113	amino acid transport
HT135_RS01785	COG3665	Urea carboxylase-associated protein
HT135_RS01790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HT135_RS01795	COG1660	Displays ATPase and GTPase activities
HT135_RS01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HT135_RS01810	COG2226	methyltransferase
HT135_RS01815	COG0583	DNA-binding transcription factor activity
HT135_RS01820	COG3458	cephalosporin-C deacetylase activity
HT135_RS01825	COG3541	Predicted nucleotidyltransferase
HT135_RS01830	COG0506	proline dehydrogenase activity
HT135_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_RS01845	COG2508	Transcriptional regulator
HT135_RS01850	COG3689	TIGRFAM TIGR03943 family protein
HT135_RS01855	COG0701	Predicted permease
HT135_RS01860	COG0492	ferredoxin-NADP+ reductase activity
HT135_RS01865	COG1587	Uroporphyrinogen-III synthase
HT135_RS01865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HT135_RS01870	COG2146	nitrite reductase [NAD(P)H] activity
HT135_RS01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_RS01880	COG0243	molybdopterin cofactor binding
HT135_RS01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_RS01890	COG2223	nitrite transmembrane transporter activity
HT135_RS01895	COG1469	GTP cyclohydrolase I activity
HT135_RS01900	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_RS01910	COG0523	cobalamin synthesis protein
HT135_RS01915	COG0765	amino acid transport
HT135_RS01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS01925	COG1063	alcohol dehydrogenase
HT135_RS01930	COG1714	RDD family
HT135_RS01940	COG3842	ATPase activity
HT135_RS01945	COG2723	6-phospho-beta-galactosidase activity
HT135_RS01955	COG3209	COG3209 Rhs family protein
HT135_RS01960	COG0840	transmembrane signaling receptor activity
HT135_RS01960	COG3290	protein histidine kinase activity
HT135_RS01965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HT135_RS01970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HT135_RS01975	COG1733	regulation of RNA biosynthetic process
HT135_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS01995	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HT135_RS02010	COG0697	spore germination
HT135_RS02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS02025	COG2364	Membrane
HT135_RS02030	COG1126	abc transporter atp-binding protein
HT135_RS02035	COG0765	amino acid transport
HT135_RS02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS02045	COG0583	DNA-binding transcription factor activity
HT135_RS02050	COG0163	prenyltransferase activity
HT135_RS02055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HT135_RS02070	COG0596	Alpha beta hydrolase
HT135_RS02075	COG3104	oligopeptide transport
HT135_RS02080	COG5434	Belongs to the glycosyl hydrolase 28 family
HT135_RS02090	COG0697	spore germination
HT135_RS02100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT135_RS02105	COG1136	(ABC) transporter
HT135_RS02110	COG0577	efflux transmembrane transporter activity
HT135_RS02115	COG0745	RESPONSE REGULATOR receiver
HT135_RS02120	COG5002	protein histidine kinase activity
HT135_RS02120	COG3850	Histidine kinase
HT135_RS02125	COG0457	Tetratricopeptide repeat
HT135_RS02145	COG0527	aspartate kinase activity
HT135_RS02150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS02155	COG4605	iron ion homeostasis
HT135_RS02160	COG4604	ABC transporter, ATP-binding protein
HT135_RS02165	COG4607	ABC-type enterochelin transport system periplasmic component
HT135_RS02170	COG2814	Major facilitator Superfamily
HT135_RS02175	COG1309	transcriptional regulator
HT135_RS02180	COG0778	Nitroreductase
HT135_RS02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HT135_RS02190	COG0640	Transcriptional regulator
HT135_RS02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HT135_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS02210	COG4975	Glucose uptake
HT135_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS02220	COG4549	nuclear export factor GLE1
HT135_RS02225	COG1276	copper resistance
HT135_RS02225	COG2372	response to copper ion
HT135_RS02230	COG1349	DNA-binding transcription factor activity
HT135_RS02240	COG2213	PTS system mannitol-specific
HT135_RS02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS02250	COG0246	Mannitol dehydrogenase
HT135_RS02255	COG0473	3-isopropylmalate dehydrogenase activity
HT135_RS02260	COG0412	Dienelactone hydrolase
HT135_RS02265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HT135_RS02275	COG0561	phosphatase activity
HT135_RS02280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HT135_RS02285	COG1914	H( )-stimulated, divalent metal cation uptake system
HT135_RS02290	COG4336	lyase activity
HT135_RS02295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HT135_RS02300	COG1984	allophanate hydrolase subunit 2
HT135_RS02305	COG1414	Transcriptional regulator
HT135_RS02310	COG2755	lipolytic protein G-D-S-L family
HT135_RS02320	COG2329	Antibiotic biosynthesis monooxygenase
HT135_RS02325	COG0768	penicillin binding
HT135_RS02330	COG4989	oxidoreductase activity
HT135_RS02335	COG3711	transcriptional antiterminator
HT135_RS02340	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS02345	COG2226	methyltransferase
HT135_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS02355	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS02360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS02365	COG3871	stress protein (general stress protein 26)
HT135_RS02375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT135_RS02380	COG2814	Major facilitator Superfamily
HT135_RS02385	COG1522	sequence-specific DNA binding
HT135_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT135_RS02390	COG0551	DNA topoisomerase type I activity
HT135_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HT135_RS02400	COG3706	GGDEF domain
HT135_RS02405	COG5298	Protein conserved in bacteria
HT135_RS02410	COG1215	transferase activity, transferring glycosyl groups
HT135_RS02420	COG0531	amino acid
HT135_RS02425	COG0494	nUDIX hydrolase
HT135_RS02430	COG0028	Belongs to the TPP enzyme family
HT135_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
HT135_RS02445	COG2261	transglycosylase associated protein
HT135_RS02450	COG4876	unkown
HT135_RS02455	COG2217	Heavy metal translocating P-type atpase
HT135_RS02460	COG3729	General stress protein
HT135_RS02465	COG0662	Cupin 2, conserved barrel domain protein
HT135_RS02480	COG3546	catalase activity
HT135_RS02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HT135_RS02490	COG3290	protein histidine kinase activity
HT135_RS02495	COG4565	transcriptional regulatory protein
HT135_RS02500	COG1301	dicarboxylic acid transport
HT135_RS02505	COG0628	permease
HT135_RS02510	COG1301	dicarboxylic acid transport
HT135_RS02515	COG1131	(ABC) transporter
HT135_RS02520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_RS02530	COG1960	acyl-CoA dehydrogenase activity
HT135_RS02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HT135_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS02555	COG1181	Belongs to the D-alanine--D-alanine ligase family
HT135_RS02560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HT135_RS02565	COG0513	Belongs to the DEAD box helicase family
HT135_RS02570	COG3402	PFAM membrane-flanked domain
HT135_RS02575	COG3428	Bacterial PH domain
HT135_RS02580	COG0705	Rhomboid family
HT135_RS02585	COG0736	holo-[acyl-carrier-protein] synthase activity
HT135_RS02590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HT135_RS02595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT135_RS02600	COG0864	Transcriptional regulator
HT135_RS02605	COG2337	Toxic component of a toxin-antitoxin (TA) module
HT135_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS02615	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS02620	COG2172	sigma factor antagonist activity
HT135_RS02625	COG2208	phosphoserine phosphatase activity
HT135_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS02635	COG2172	sigma factor antagonist activity
HT135_RS02640	COG1191	sigma factor activity
HT135_RS02645	COG2208	phosphoserine phosphatase activity
HT135_RS02660	COG1846	Transcriptional regulator
HT135_RS02665	COG2183	response to ionizing radiation
HT135_RS02675	COG3091	SprT-like family
HT135_RS02750	COG0604	alcohol dehydrogenase
HT135_RS02760	COG3239	Fatty acid desaturase
HT135_RS02765	COG1278	Cold shock
HT135_RS02770	COG1278	Cold shock
HT135_RS02775	COG1329	Transcriptional regulator
HT135_RS02780	COG2315	Protein conserved in bacteria
HT135_RS02785	COG0346	lactoylglutathione lyase activity
HT135_RS02805	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HT135_RS02820	COG2364	Membrane
HT135_RS02825	COG1846	Transcriptional regulator
HT135_RS02830	COG0456	acetyltransferase
HT135_RS02835	COG2808	Putative FMN-binding domain
HT135_RS02845	COG0697	spore germination
HT135_RS02850	COG0693	protein deglycase activity
HT135_RS02865	COG0697	spore germination
HT135_RS02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS02875	COG0640	Transcriptional regulator
HT135_RS02880	COG0346	lactoylglutathione lyase activity
HT135_RS02890	COG3764	Sortase (surface protein transpeptidase)
HT135_RS02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS02905	COG0456	acetyltransferase
HT135_RS02910	COG4978	Transcriptional regulator
HT135_RS02910	COG0789	Transcriptional regulator
HT135_RS02915	COG0702	epimerase
HT135_RS02925	COG3711	transcriptional antiterminator
HT135_RS02925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS02930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_RS02930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_RS02930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS02935	COG1482	cell wall glycoprotein biosynthetic process
HT135_RS02940	COG2030	dehydratase
HT135_RS02945	COG0697	spore germination
HT135_RS02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS02955	COG0596	Alpha beta hydrolase
HT135_RS02960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS02975	COG0778	Nitroreductase
HT135_RS02980	COG0346	lactoylglutathione lyase activity
HT135_RS02985	COG2259	Doxx family
HT135_RS02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS02995	COG1309	transcriptional regulator
HT135_RS03005	COG0456	acetyltransferase
HT135_RS03015	COG0673	inositol 2-dehydrogenase activity
HT135_RS03020	COG1609	Transcriptional regulator
HT135_RS03025	COG2814	Major facilitator Superfamily
HT135_RS03030	COG1082	Xylose isomerase domain protein TIM barrel
HT135_RS03035	COG0488	(ABC) transporter
HT135_RS03040	COG1113	amino acid transport
HT135_RS03045	COG2318	DinB family
HT135_RS03050	COG1846	Transcriptional regulator
HT135_RS03055	COG1033	growth of symbiont in host cell
HT135_RS03055	COG2409	Drug exporters of the RND superfamily
HT135_RS03065	COG0778	Nitroreductase
HT135_RS03070	COG1846	Transcriptional regulator
HT135_RS03075	COG1396	sequence-specific DNA binding
HT135_RS03080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HT135_RS03090	COG2814	Major facilitator Superfamily
HT135_RS03095	COG0730	response to heat
HT135_RS03100	COG1802	Transcriptional regulator
HT135_RS03105	COG1388	LysM domain
HT135_RS03105	COG3858	chitin binding
HT135_RS03125	COG1785	Belongs to the alkaline phosphatase family
HT135_RS03130	COG1078	dGTPase activity
HT135_RS03135	COG1388	LysM domain
HT135_RS03140	COG2814	Major facilitator Superfamily
HT135_RS03145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_RS03150	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT135_RS03155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_RS03160	COG2723	6-phospho-beta-galactosidase activity
HT135_RS03165	COG2188	Transcriptional regulator
HT135_RS03170	COG1940	carbohydrate kinase activity
HT135_RS03175	COG1482	cell wall glycoprotein biosynthetic process
HT135_RS03180	COG4124	Belongs to the glycosyl hydrolase 26 family
HT135_RS03225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HT135_RS03230	COG0802	atpase or kinase
HT135_RS03235	COG1214	PFAM Peptidase M22, glycoprotease
HT135_RS03240	COG0456	acetyltransferase
HT135_RS03245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HT135_RS03250	COG0488	(ABC) transporter
HT135_RS03255	COG0315	cyclic pyranopterin monophosphate synthase activity
HT135_RS03260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HT135_RS03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_RS03270	COG0805	protein transport
HT135_RS03280	COG1266	CAAX protease self-immunity
HT135_RS03295	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS03305	COG0457	Tetratricopeptide repeat
HT135_RS03310	COG1063	alcohol dehydrogenase
HT135_RS03315	COG2211	Major facilitator Superfamily
HT135_RS03320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_RS03325	COG1842	Phage shock protein A
HT135_RS03330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HT135_RS03335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HT135_RS03340	COG4260	virion core protein, lumpy skin disease virus
HT135_RS03350	COG2814	Major facilitator Superfamily
HT135_RS03355	COG1063	alcohol dehydrogenase
HT135_RS03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HT135_RS03365	COG0823	Involved in the tonB-independent uptake of proteins
HT135_RS03380	COG2267	carboxylic ester hydrolase activity
HT135_RS03390	COG2132	Multicopper oxidase
HT135_RS03395	COG1113	amino acid transport
HT135_RS03400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HT135_RS03405	COG0714	Associated with various cellular activities
HT135_RS03410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HT135_RS03415	COG1305	Transglutaminase-like
HT135_RS03420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HT135_RS03420	COG0519	Catalyzes the synthesis of GMP from XMP
HT135_RS03435	COG2252	PERMEase
HT135_RS03440	COG3064	Membrane
HT135_RS03450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HT135_RS03460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HT135_RS03465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HT135_RS03470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HT135_RS03475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HT135_RS03480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HT135_RS03485	COG0047	phosphoribosylformylglycinamidine synthase activity
HT135_RS03490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HT135_RS03495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HT135_RS03500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HT135_RS03505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HT135_RS03510	COG0138	bifunctional purine biosynthesis protein purh
HT135_RS03515	COG0151	Belongs to the GarS family
HT135_RS03520	COG1522	sequence-specific DNA binding
HT135_RS03525	COG0531	amino acid
HT135_RS03535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HT135_RS03540	COG1470	cell adhesion involved in biofilm formation
HT135_RS03545	COG4496	protein, YerC YecD
HT135_RS03550	COG0069	glutamate synthase activity
HT135_RS03555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HT135_RS03560	COG0210	DNA helicase
HT135_RS03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HT135_RS03570	COG4851	CamS sex pheromone cAM373 precursor
HT135_RS03575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_RS03580	COG1285	pathogenesis
HT135_RS03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_RS03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HT135_RS03595	COG0154	amidase activity
HT135_RS03600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HT135_RS03605	COG1309	transcriptional regulator
HT135_RS03610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT135_RS03615	COG1597	lipid kinase activity
HT135_RS03620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HT135_RS03635	COG0457	Tetratricopeptide repeat
HT135_RS03675	COG5444	nuclease activity
HT135_RS03680	COG3391	amine dehydrogenase activity
HT135_RS03685	COG0457	Tetratricopeptide repeat
HT135_RS03695	COG0217	transcriptional regulatory protein
HT135_RS03710	COG1309	transcriptional regulator
HT135_RS03715	COG3631	Ketosteroid isomerase-related protein
HT135_RS03720	COG0702	epimerase
HT135_RS03725	COG2159	amidohydrolase
HT135_RS03730	COG1309	transcriptional regulator
HT135_RS03745	COG3546	catalase activity
HT135_RS03750	COG0454	-acetyltransferase
HT135_RS03760	COG5578	integral membrane protein
HT135_RS03765	COG2972	Histidine kinase
HT135_RS03770	COG4753	response regulator
HT135_RS03770	COG2207	Transcriptional regulator
HT135_RS03775	COG1653	transport
HT135_RS03780	COG1175	transmembrane transport
HT135_RS03785	COG0395	ABC-type sugar transport system, permease component
HT135_RS03790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HT135_RS03795	COG2207	Transcriptional regulator
HT135_RS03800	COG2755	lipolytic protein G-D-S-L family
HT135_RS03810	COG5578	integral membrane protein
HT135_RS03815	COG3401	FG-GAP repeat protein
HT135_RS03820	COG3401	FG-GAP repeat protein
HT135_RS03825	COG0667	Aldo Keto reductase
HT135_RS03830	COG2755	lipolytic protein G-D-S-L family
HT135_RS03835	COG1874	Beta-galactosidase
HT135_RS03845	COG1653	transport
HT135_RS03850	COG4209	transmembrane transport
HT135_RS03855	COG0395	ABC-type sugar transport system, permease component
HT135_RS03860	COG1486	melibiose metabolic process
HT135_RS03865	COG2323	membrane
HT135_RS03870	COG2329	Antibiotic biosynthesis monooxygenase
HT135_RS03875	COG0346	lactoylglutathione lyase activity
HT135_RS03885	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS03890	COG5583	Uncharacterized small protein (DUF2292)
HT135_RS03895	COG0670	Belongs to the BI1 family
HT135_RS03900	COG1846	Transcriptional regulator
HT135_RS03905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_RS03915	COG2124	cytochrome p450
HT135_RS03915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_RS03920	COG1368	sulfuric ester hydrolase activity
HT135_RS03925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HT135_RS03930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_RS03935	COG1442	glycosyl transferase family 8
HT135_RS03940	COG1216	Glycosyl transferase, family 2
HT135_RS03945	COG1442	glycosyl transferase family 8
HT135_RS03950	COG2223	nitrite transmembrane transporter activity
HT135_RS03955	COG1011	Hydrolase
HT135_RS03960	COG0531	amino acid
HT135_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS03970	COG0840	transmembrane signaling receptor activity
HT135_RS03975	COG0488	(ABC) transporter
HT135_RS03985	COG0789	Transcriptional regulator
HT135_RS03990	COG2814	Major facilitator Superfamily
HT135_RS04000	COG0488	(ABC) transporter
HT135_RS04005	COG0513	Belongs to the DEAD box helicase family
HT135_RS04010	COG0456	acetyltransferase
HT135_RS04015	COG2130	NADP-dependent
HT135_RS04020	COG1120	ATPase activity
HT135_RS04025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS04035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HT135_RS04050	COG3866	Pectate lyase
HT135_RS04055	COG0471	metal ion transport
HT135_RS04075	COG0463	Glycosyl transferase, family 2
HT135_RS04085	COG3290	protein histidine kinase activity
HT135_RS04090	COG4565	transcriptional regulatory protein
HT135_RS04095	COG3181	Tripartite tricarboxylate transporter family receptor
HT135_RS04100	COG2851	Citrate transporter
HT135_RS04105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS04110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HT135_RS04115	COG1254	Belongs to the acylphosphatase family
HT135_RS04120	COG2258	MOSC domain
HT135_RS04140	COG0024	Methionine aminopeptidase
HT135_RS04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS04145	COG1263	PTS System
HT135_RS04150	COG1368	sulfuric ester hydrolase activity
HT135_RS04160	COG1115	amino acid carrier protein
HT135_RS04165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS04165	COG1263	PTS System
HT135_RS04170	COG0366	Alpha amylase catalytic
HT135_RS04175	COG2188	Transcriptional regulator
HT135_RS04180	COG0778	Nitroreductase
HT135_RS04185	COG0737	Belongs to the 5'-nucleotidase family
HT135_RS04190	COG0693	protein deglycase activity
HT135_RS04195	COG2814	Major facilitator Superfamily
HT135_RS04200	COG4840	Belongs to the UPF0435 family
HT135_RS04205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_RS04210	COG4980	gas vesicle protein
HT135_RS04215	COG1295	ribonuclease BN
HT135_RS04220	COG0477	Major facilitator Superfamily
HT135_RS04225	COG0387	Pfam Sodium calcium exchanger
HT135_RS04235	COG0668	transmembrane transport
HT135_RS04240	COG0535	radical SAM domain protein
HT135_RS04250	COG0726	polysaccharide deacetylase
HT135_RS04260	COG2084	Dehydrogenase
HT135_RS04265	COG0598	Magnesium transport protein CorA
HT135_RS04270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HT135_RS04275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HT135_RS04285	COG1132	(ABC) transporter
HT135_RS04290	COG0515	serine threonine protein kinase
HT135_RS04300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT135_RS04310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HT135_RS04325	COG4637	Psort location Cytoplasmic, score
HT135_RS04340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_RS04345	COG0022	dehydrogenase e1 component
HT135_RS04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_RS04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_RS04360	COG3284	Transcriptional regulator
HT135_RS04370	COG1742	UPF0060 membrane protein
HT135_RS04395	COG4842	Belongs to the WXG100 family
HT135_RS04400	COG1486	melibiose metabolic process
HT135_RS04405	COG1737	Transcriptional regulator
HT135_RS04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS04410	COG1263	PTS System
HT135_RS04415	COG1132	(ABC) transporter
HT135_RS04420	COG1132	(ABC) transporter
HT135_RS04425	COG2259	Doxx family
HT135_RS04430	COG2514	catechol 2,3-dioxygenase activity
HT135_RS04435	COG4977	sequence-specific DNA binding
HT135_RS04435	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS04440	COG2814	Major facilitator Superfamily
HT135_RS04445	COG1082	Xylose isomerase domain protein TIM barrel
HT135_RS04450	COG0673	inositol 2-dehydrogenase activity
HT135_RS04455	COG4585	Histidine kinase
HT135_RS04460	COG2197	response regulator
HT135_RS04465	COG1131	(ABC) transporter
HT135_RS04470	COG1511	domain protein
HT135_RS04470	COG0842	Transport permease protein
HT135_RS04475	COG0842	Transport permease protein
HT135_RS04480	COG1695	Transcriptional regulator
HT135_RS04485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HT135_RS04490	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HT135_RS04495	COG2318	DinB family
HT135_RS04500	COG2814	Major facilitator Superfamily
HT135_RS04505	COG1846	Transcriptional regulator
HT135_RS04510	COG0392	lysyltransferase activity
HT135_RS04510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HT135_RS04515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS04525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS04530	COG0384	phenazine biosynthesis protein PhzF
HT135_RS04535	COG0778	Nitroreductase
HT135_RS04550	COG1090	epimerase
HT135_RS04555	COG2137	regulation of response to DNA damage stimulus
HT135_RS04565	COG2814	Major facilitator Superfamily
HT135_RS04580	COG1476	TRANSCRIPTIONal
HT135_RS04585	COG3103	Sh3 type 3 domain protein
HT135_RS04590	COG5658	integral membrane protein
HT135_RS04595	COG0596	Alpha beta hydrolase
HT135_RS04600	COG0463	Glycosyl transferase, family 2
HT135_RS04605	COG4485	Bacterial membrane protein, YfhO
HT135_RS04610	COG1988	membrane-bound metal-dependent
HT135_RS04615	COG1194	a g-specific adenine glycosylase
HT135_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS04640	COG3557	Belongs to the UPF0374 family
HT135_RS04645	COG1132	(ABC) transporter
HT135_RS04650	COG4129	membrane
HT135_RS04655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HT135_RS04660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HT135_RS04665	COG0735	belongs to the Fur family
HT135_RS04775	COG4326	sporulation control protein
HT135_RS04785	COG1063	alcohol dehydrogenase
HT135_RS04790	COG5577	PFAM Coat F domain
HT135_RS04805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HT135_RS04815	COG0753	catalase activity
HT135_RS04820	COG1116	anion transmembrane transporter activity
HT135_RS04825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HT135_RS04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT135_RS04835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS04845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HT135_RS04855	COG1476	TRANSCRIPTIONal
HT135_RS04865	COG3382	B3 4 domain protein
HT135_RS04870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HT135_RS04880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HT135_RS04885	COG0789	Transcriptional regulator
HT135_RS04890	COG1664	Polymer-forming cytoskeletal
HT135_RS04900	COG2766	serine protein kinase
HT135_RS04905	COG2718	Belongs to the UPF0229 family
HT135_RS04910	COG1846	Transcriptional regulator
HT135_RS04915	COG1566	PFAM secretion protein HlyD family protein
HT135_RS04920	COG2814	Major facilitator Superfamily
HT135_RS04925	COG0655	NAD(P)H dehydrogenase (quinone) activity
HT135_RS04940	COG1725	Transcriptional regulator
HT135_RS04945	COG1131	(ABC) transporter
HT135_RS04950	COG1131	(ABC) transporter
HT135_RS04955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_RS04960	COG1278	Cold shock
HT135_RS04965	COG1464	Belongs to the NlpA lipoprotein family
HT135_RS04970	COG3706	GGDEF domain
HT135_RS04975	COG1823	symporter activity
HT135_RS04995	COG5577	PFAM Coat F domain
HT135_RS05000	COG0737	Belongs to the 5'-nucleotidase family
HT135_RS05000	COG1525	nuclease
HT135_RS05000	COG4085	toxin activity
HT135_RS05005	COG3764	Sortase (surface protein transpeptidase)
HT135_RS05010	COG0564	pseudouridine synthase activity
HT135_RS05020	COG0517	IMP dehydrogenase activity
HT135_RS05025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT135_RS05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT135_RS05030	COG3153	acetyltransferase
HT135_RS05040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_RS05045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HT135_RS05050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HT135_RS05055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HT135_RS05060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HT135_RS05065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HT135_RS05070	COG4585	Histidine kinase
HT135_RS05070	COG2203	Gaf domain
HT135_RS05075	COG2197	response regulator
HT135_RS05080	COG0431	NADPH-dependent FMN reductase
HT135_RS05095	COG1388	LysM domain
HT135_RS05095	COG0791	NLP P60 protein
HT135_RS05100	COG1959	2 iron, 2 sulfur cluster binding
HT135_RS05105	COG0668	transmembrane transport
HT135_RS05110	COG2719	SpoVR family
HT135_RS05115	COG1785	Belongs to the alkaline phosphatase family
HT135_RS05120	COG0791	NLP P60 protein
HT135_RS05120	COG1388	LysM domain
HT135_RS05125	COG0583	DNA-binding transcription factor activity
HT135_RS05130	COG0372	Belongs to the citrate synthase family
HT135_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS05140	COG0531	amino acid
HT135_RS05145	COG0733	neurotransmitter:sodium symporter activity
HT135_RS05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS05155	COG0456	acetyltransferase
HT135_RS05170	COG1595	DNA-templated transcription, initiation
HT135_RS05175	COG0667	Aldo Keto reductase
HT135_RS05180	COG0204	Acyl-transferase
HT135_RS05185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_RS05190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_RS05195	COG1253	flavin adenine dinucleotide binding
HT135_RS05200	COG0789	Transcriptional regulator
HT135_RS05205	COG0436	Aminotransferase
HT135_RS05210	COG1253	flavin adenine dinucleotide binding
HT135_RS05215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HT135_RS05220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HT135_RS05225	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_RS05235	COG0668	transmembrane transport
HT135_RS05240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HT135_RS05245	COG0726	polysaccharide deacetylase
HT135_RS05250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_RS05260	COG1757	Na H antiporter
HT135_RS05265	COG0589	response to stress
HT135_RS05270	COG1132	(ABC) transporter
HT135_RS05275	COG1132	(ABC) transporter
HT135_RS05280	COG0702	epimerase
HT135_RS05300	COG0189	ligase activity
HT135_RS05305	COG0189	ligase activity
HT135_RS05310	COG4399	Belongs to the UPF0754 family
HT135_RS05315	COG3679	Belongs to the UPF0342 family
HT135_RS05320	COG4335	DNA alkylation repair
HT135_RS05325	COG0561	phosphatase activity
HT135_RS05330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT135_RS05335	COG0475	glutathione-regulated potassium exporter activity
HT135_RS05340	COG0490	domain, Protein
HT135_RS05350	COG1024	Enoyl-CoA hydratase
HT135_RS05360	COG4152	abc transporter atp-binding protein
HT135_RS05365	COG1668	transmembrane transport
HT135_RS05370	COG0420	3'-5' exonuclease activity
HT135_RS05375	COG4717	serine-type aminopeptidase activity
HT135_RS05380	COG3481	metal-dependent phosphohydrolase, HD sub domain
HT135_RS05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT135_RS05420	COG1846	Transcriptional regulator
HT135_RS05425	COG4980	gas vesicle protein
HT135_RS05440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HT135_RS05445	COG0537	adenosine 5'-monophosphoramidase activity
HT135_RS05450	COG1131	(ABC) transporter
HT135_RS05455	COG4473	ABC transporter
HT135_RS05465	COG1473	amidohydrolase
HT135_RS05470	COG3069	C4-dicarboxylate transmembrane transporter activity
HT135_RS05480	COG2329	Antibiotic biosynthesis monooxygenase
HT135_RS05485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_RS05490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HT135_RS05495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HT135_RS05500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HT135_RS05505	COG1309	transcriptional regulator
HT135_RS05510	COG1511	domain protein
HT135_RS05515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_RS05520	COG4377	Putative membrane peptidase family (DUF2324)
HT135_RS05525	COG1363	Peptidase, m42
HT135_RS05530	COG4405	Protein conserved in bacteria
HT135_RS05535	COG1301	dicarboxylic acid transport
HT135_RS05545	COG1234	tRNA 3'-trailer cleavage
HT135_RS05550	COG0095	Lipoate-protein ligase
HT135_RS05555	COG0702	epimerase
HT135_RS05560	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS05570	COG0501	Belongs to the peptidase M48B family
HT135_RS05575	COG1404	Belongs to the peptidase S8 family
HT135_RS05580	COG0456	acetyltransferase
HT135_RS05585	COG0604	alcohol dehydrogenase
HT135_RS05590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HT135_RS05595	COG0406	alpha-ribazole phosphatase activity
HT135_RS05600	COG0183	Belongs to the thiolase family
HT135_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS05610	COG1268	BioY protein
HT135_RS05615	COG0840	transmembrane signaling receptor activity
HT135_RS05620	COG0723	plastoquinol--plastocyanin reductase activity
HT135_RS05620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS05635	COG4903	ComK protein
HT135_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS05655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_RS05670	COG0398	Pfam SNARE associated Golgi protein
HT135_RS05675	COG0681	Belongs to the peptidase S26 family
HT135_RS05680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_RS05685	COG1846	Transcriptional regulator
HT135_RS05695	COG0738	Major facilitator superfamily
HT135_RS05700	COG0673	inositol 2-dehydrogenase activity
HT135_RS05705	COG0561	phosphatase activity
HT135_RS05710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_RS05715	COG1609	Transcriptional regulator
HT135_RS05720	COG3180	Ammonia monooxygenase
HT135_RS05725	COG2814	Major facilitator Superfamily
HT135_RS05725	COG0477	Major facilitator Superfamily
HT135_RS05730	COG4533	DNA binding
HT135_RS05740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HT135_RS05745	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HT135_RS05750	COG1074	ATP-dependent DNA helicase activity
HT135_RS05755	COG0420	3'-5' exonuclease activity
HT135_RS05760	COG0419	ATPase involved in DNA repair
HT135_RS05765	COG1403	HNH endonuclease
HT135_RS05805	COG5337	Spore coat protein CotH
HT135_RS05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
HT135_RS05820	COG1404	Belongs to the peptidase S8 family
HT135_RS05830	COG0367	asparagine synthase
HT135_RS05835	COG2318	DinB family
HT135_RS05840	COG1562	ergosterol biosynthetic process
HT135_RS05845	COG0534	Mate efflux family protein
HT135_RS05850	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS05850	COG2207	Transcriptional regulator
HT135_RS05855	COG1609	Transcriptional regulator
HT135_RS05860	COG0673	inositol 2-dehydrogenase activity
HT135_RS05865	COG2318	DinB family
HT135_RS05870	COG1279	arginine transmembrane transporter activity
HT135_RS05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS05880	COG1357	PFAM Pentapeptide repeats (8 copies)
HT135_RS05885	COG2267	carboxylic ester hydrolase activity
HT135_RS05890	COG0529	Catalyzes the synthesis of activated sulfate
HT135_RS05895	COG2046	Belongs to the sulfate adenylyltransferase family
HT135_RS05900	COG0175	sulfate reduction
HT135_RS05905	COG2045	Belongs to the ComB family
HT135_RS05910	COG1809	phosphosulfolactate synthase activity
HT135_RS05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS05920	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_RS05925	COG2814	Major facilitator Superfamily
HT135_RS05930	COG0454	-acetyltransferase
HT135_RS05935	COG2153	protein acetylation
HT135_RS05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HT135_RS05940	COG0646	methionine synthase
HT135_RS05945	COG1666	GTP binding
HT135_RS05950	COG2996	Protein conserved in bacteria
HT135_RS05970	COG1695	Transcriptional regulator
HT135_RS05985	COG3227	Zinc metalloprotease (Elastase)
HT135_RS05990	COG1307	EDD domain protein, DegV family
HT135_RS05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS06015	COG0561	phosphatase activity
HT135_RS06020	COG1073	alpha beta
HT135_RS06025	COG2151	metal-sulfur cluster biosynthetic enzyme
HT135_RS06035	COG0277	FAD linked oxidase domain protein
HT135_RS06040	COG2271	Major facilitator Superfamily
HT135_RS06045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HT135_RS06050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HT135_RS06060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HT135_RS06065	COG0505	Belongs to the CarA family
HT135_RS06070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HT135_RS06075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HT135_RS06090	COG2267	carboxylic ester hydrolase activity
HT135_RS06100	COG1744	ABC transporter substrate-binding protein PnrA-like
HT135_RS06115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_RS06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_RS06125	COG5504	Zn-dependent protease
HT135_RS06130	COG0444	Belongs to the ABC transporter superfamily
HT135_RS06135	COG4608	Belongs to the ABC transporter superfamily
HT135_RS06145	COG0601	transmembrane transport
HT135_RS06150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_RS06160	COG0180	Tryptophanyl-tRNA synthetase
HT135_RS06165	COG4166	transmembrane transport
HT135_RS06170	COG0601	transmembrane transport
HT135_RS06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_RS06180	COG0444	Belongs to the ABC transporter superfamily
HT135_RS06185	COG4608	Belongs to the ABC transporter superfamily
HT135_RS06190	COG2814	Major facilitator Superfamily
HT135_RS06195	COG0456	acetyltransferase
HT135_RS06200	COG1393	Belongs to the ArsC family
HT135_RS06205	COG0861	Integral membrane protein TerC family
HT135_RS06215	COG4862	establishment of competence for transformation
HT135_RS06220	COG4469	Competence protein
HT135_RS06225	COG1164	Oligoendopeptidase f
HT135_RS06235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HT135_RS06240	COG2346	COG2346, Truncated hemoglobins
HT135_RS06245	COG0741	lytic transglycosylase activity
HT135_RS06250	COG4116	CYTH
HT135_RS06260	COG2357	RelA SpoT domain protein
HT135_RS06265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HT135_RS06270	COG0564	pseudouridine synthase activity
HT135_RS06275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HT135_RS06280	COG0475	glutathione-regulated potassium exporter activity
HT135_RS06280	COG0569	domain protein
HT135_RS06285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HT135_RS06290	COG0352	thiamine-phosphate diphosphorylase activity
HT135_RS06295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_RS06300	COG2104	thiamine diphosphate biosynthetic process
HT135_RS06305	COG2022	thiamine diphosphate biosynthetic process
HT135_RS06310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT135_RS06315	COG0351	phosphomethylpyrimidine kinase
HT135_RS06320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HT135_RS06375	COG0210	DNA helicase
HT135_RS06385	COG2153	protein acetylation
HT135_RS06390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HT135_RS06395	COG2382	esterase
HT135_RS06400	COG0626	cystathionine gamma-synthase activity
HT135_RS06405	COG0626	cystathionine gamma-synthase activity
HT135_RS06410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS06415	COG5505	Protein of unknown function (DUF819)
HT135_RS06425	COG0582	viral genome integration into host DNA
HT135_RS06440	COG3645	SOS response
HT135_RS06440	COG3646	Phage regulatory protein
HT135_RS06560	COG3953	SLT domain
HT135_RS06560	COG5280	Phage tail tape measure protein TP901
HT135_RS06595	COG4824	toxin secretion phage lysis holin
HT135_RS06600	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS06600	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS06660	COG5444	nuclease activity
HT135_RS06675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HT135_RS06705	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS06725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS06730	COG0583	DNA-binding transcription factor activity
HT135_RS06735	COG0697	spore germination
HT135_RS06745	COG0789	Transcriptional regulator
HT135_RS06765	COG0109	protoheme IX farnesyltransferase activity
HT135_RS06775	COG0726	polysaccharide deacetylase
HT135_RS06790	COG5504	Zn-dependent protease
HT135_RS06795	COG2205	protein histidine kinase activity
HT135_RS06805	COG3383	formate dehydrogenase (NAD+) activity
HT135_RS06810	COG2427	Protein of unknown function (DUF1641)
HT135_RS06820	COG1051	belongs to the nudix hydrolase family
HT135_RS06830	COG2124	cytochrome p450
HT135_RS06835	COG1819	glycosyl
HT135_RS06850	COG1587	Uroporphyrinogen-III synthase
HT135_RS06855	COG0390	transport system, permease component
HT135_RS06860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_RS06865	COG0697	spore germination
HT135_RS06870	COG4297	protein containing double-stranded beta helix domain
HT135_RS06880	COG1252	NADH dehydrogenase
HT135_RS06885	COG1904	glucuronate isomerase
HT135_RS06890	COG2211	Major facilitator Superfamily
HT135_RS06895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HT135_RS06900	COG1063	alcohol dehydrogenase
HT135_RS06905	COG1312	Catalyzes the dehydration of D-mannonate
HT135_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS06915	COG2271	Major facilitator Superfamily
HT135_RS06920	COG1609	Transcriptional regulator
HT135_RS06925	COG0246	Mannitol dehydrogenase
HT135_RS06930	COG2721	sulfolactate sulfo-lyase activity
HT135_RS06935	COG0730	response to heat
HT135_RS06940	COG2318	DinB family
HT135_RS06945	COG0457	Tetratricopeptide repeat
HT135_RS06955	COG2350	Protein conserved in bacteria
HT135_RS06960	COG1388	LysM domain
HT135_RS06960	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS06960	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS06970	COG4195	phage-related replication protein
HT135_RS06975	COG3546	catalase activity
HT135_RS06980	COG2856	Zn peptidase
HT135_RS06985	COG1396	sequence-specific DNA binding
HT135_RS06995	COG1522	sequence-specific DNA binding
HT135_RS07000	COG1484	DNA-dependent DNA replication
HT135_RS07020	COG1595	DNA-templated transcription, initiation
HT135_RS07025	COG3728	DNA packaging
HT135_RS07025	COG5484	DNA packaging
HT135_RS07030	COG1783	phage Terminase large subunit
HT135_RS07035	COG5518	Phage portal protein
HT135_RS07040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HT135_RS07045	COG4653	Phage capsid family
HT135_RS07095	COG3953	SLT domain
HT135_RS07095	COG5412	phage tail tape measure protein
HT135_RS07100	COG1652	LysM domain
HT135_RS07105	COG4193	domain, Protein
HT135_RS07115	COG3628	GPW Gp25 family protein
HT135_RS07120	COG3299	homolog of phage Mu protein gp47
HT135_RS07125	COG3778	Protein conserved in bacteria
HT135_RS07165	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS07165	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS07185	COG0306	phosphate transporter
HT135_RS07190	COG1392	Phosphate transport regulator
HT135_RS07195	COG0531	amino acid
HT135_RS07200	COG0346	lactoylglutathione lyase activity
HT135_RS07205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HT135_RS07210	COG0463	Glycosyl transferase, family 2
HT135_RS07220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_RS07225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_RS07230	COG2362	D-Aminopeptidase
HT135_RS07235	COG0601	transmembrane transport
HT135_RS07240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_RS07245	COG0444	Belongs to the ABC transporter superfamily
HT135_RS07250	COG4166	transmembrane transport
HT135_RS07255	COG1619	proteins homologs of microcin C7 resistance protein MccF
HT135_RS07260	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_RS07265	COG0791	NLP P60 protein
HT135_RS07270	COG4608	Belongs to the ABC transporter superfamily
HT135_RS07275	COG2706	6-phosphogluconolactonase activity
HT135_RS07280	COG1834	amidinotransferase
HT135_RS07285	COG1607	acyl-coa hydrolase
HT135_RS07290	COG1017	nitric oxide dioxygenase activity
HT135_RS07290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT135_RS07300	COG2323	membrane
HT135_RS07305	COG2318	DinB family
HT135_RS07310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS07315	COG2076	Multidrug Resistance protein
HT135_RS07320	COG2076	Multidrug Resistance protein
HT135_RS07325	COG0788	formyltetrahydrofolate deformylase activity
HT135_RS07330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HT135_RS07335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HT135_RS07340	COG1764	response to oxidative stress
HT135_RS07345	COG1846	Transcriptional regulator
HT135_RS07350	COG1764	response to oxidative stress
HT135_RS07355	COG0457	Tetratricopeptide repeat
HT135_RS07355	COG0463	Glycosyl transferase, family 2
HT135_RS07360	COG0590	tRNA wobble adenosine to inosine editing
HT135_RS07365	COG0406	alpha-ribazole phosphatase activity
HT135_RS07370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_RS07375	COG1404	Belongs to the peptidase S8 family
HT135_RS07380	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS07385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HT135_RS07390	COG1122	ATPase activity
HT135_RS07395	COG4721	ABC-type cobalt transport system, permease component
HT135_RS07405	COG0745	RESPONSE REGULATOR receiver
HT135_RS07410	COG5002	protein histidine kinase activity
HT135_RS07410	COG3850	Histidine kinase
HT135_RS07415	COG3212	peptidase
HT135_RS07420	COG3212	peptidase
HT135_RS07430	COG2239	Acts as a magnesium transporter
HT135_RS07435	COG0789	Transcriptional regulator
HT135_RS07450	COG1846	Transcriptional regulator
HT135_RS07455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_RS07460	COG0726	polysaccharide deacetylase
HT135_RS07465	COG1408	metallophosphoesterase
HT135_RS07475	COG0463	Glycosyl transferase, family 2
HT135_RS07480	COG3285	dna ligase
HT135_RS07480	COG1793	dna ligase
HT135_RS07485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HT135_RS07490	COG5001	Diguanylate cyclase
HT135_RS07490	COG3300	MHYT domain
HT135_RS07495	COG0586	Pfam SNARE associated Golgi protein
HT135_RS07500	COG0861	Integral membrane protein TerC family
HT135_RS07505	COG1191	sigma factor activity
HT135_RS07525	COG0501	Belongs to the peptidase M48B family
HT135_RS07530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HT135_RS07545	COG3594	Acyltransferase
HT135_RS07550	COG5002	protein histidine kinase activity
HT135_RS07555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HT135_RS07565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HT135_RS07570	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HT135_RS07575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT135_RS07580	COG0436	Aminotransferase
HT135_RS07585	COG1850	ribulose-bisphosphate carboxylase activity
HT135_RS07590	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HT135_RS07595	COG0235	Class ii aldolase
HT135_RS07600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HT135_RS07605	COG3339	Conserved Protein
HT135_RS07620	COG3852	Histidine kinase
HT135_RS07625	COG1846	Transcriptional regulator
HT135_RS07630	COG1360	Flagellar Motor Protein
HT135_RS07635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HT135_RS07640	COG0542	response to heat
HT135_RS07645	COG3949	Membrane
HT135_RS07650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HT135_RS07655	COG0720	synthase
HT135_RS07660	COG0602	queuosine metabolic process
HT135_RS07665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HT135_RS07670	COG4641	Protein conserved in bacteria
HT135_RS07670	COG1388	LysM domain
HT135_RS07675	COG1388	LysM domain
HT135_RS07680	COG3858	chitin binding
HT135_RS07690	COG4873	Protein conserved in bacteria
HT135_RS07700	COG3773	Cell wall hydrolase
HT135_RS07705	COG2244	polysaccharide biosynthetic process
HT135_RS07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS07715	COG2217	Heavy metal translocating P-type atpase
HT135_RS07725	COG0006	proline dipeptidase activity
HT135_RS07730	COG1609	Transcriptional regulator
HT135_RS07735	COG3711	transcriptional antiterminator
HT135_RS07740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS07740	COG2190	(PTS) system
HT135_RS07740	COG1263	PTS System
HT135_RS07745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS07750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT135_RS07760	COG1533	DNA photolyase activity
HT135_RS07770	COG0840	transmembrane signaling receptor activity
HT135_RS07775	COG2084	Dehydrogenase
HT135_RS07780	COG2340	Cysteine-rich secretory protein family
HT135_RS07785	COG0768	penicillin binding
HT135_RS07790	COG4191	Histidine kinase
HT135_RS07795	COG0436	Aminotransferase
HT135_RS07805	COG0784	Response regulator, receiver
HT135_RS07805	COG0835	chemotaxis
HT135_RS07815	COG2814	Major facilitator Superfamily
HT135_RS07820	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_RS07825	COG1408	metallophosphoesterase
HT135_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS07835	COG2200	EAL domain
HT135_RS07840	COG3546	catalase activity
HT135_RS07845	COG4703	Protein of unknown function (DUF1797)
HT135_RS07850	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HT135_RS07860	COG0517	IMP dehydrogenase activity
HT135_RS07865	COG0583	DNA-binding transcription factor activity
HT135_RS07870	COG0716	FMN binding
HT135_RS07880	COG0716	FMN binding
HT135_RS07885	COG2171	N-acyltransferase activity
HT135_RS07890	COG1473	amidohydrolase
HT135_RS07900	COG0668	transmembrane transport
HT135_RS07905	COG0450	alkyl hydroperoxide reductase
HT135_RS07910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS07925	COG0746	molybdenum cofactor guanylyltransferase activity
HT135_RS07930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT135_RS07935	COG0303	'Molybdopterin
HT135_RS07940	COG1763	Mo-molybdopterin cofactor biosynthetic process
HT135_RS07945	COG0314	molybdopterin synthase activity
HT135_RS07950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HT135_RS07955	COG1132	(ABC) transporter
HT135_RS07960	COG1132	(ABC) transporter
HT135_RS07970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT135_RS07975	COG1136	(ABC) transporter
HT135_RS07980	COG0577	efflux transmembrane transporter activity
HT135_RS07985	COG1349	DNA-binding transcription factor activity
HT135_RS07990	COG1105	Belongs to the carbohydrate kinase PfkB family
HT135_RS07995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_RS07995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_RS07995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS08000	COG0681	Belongs to the peptidase S26 family
HT135_RS08010	COG0488	(ABC) transporter
HT135_RS08015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HT135_RS08020	COG2309	aminopeptidase activity
HT135_RS08030	COG1077	Cell shape determining protein MreB Mrl
HT135_RS08035	COG2002	toxin-antitoxin pair type II binding
HT135_RS08040	COG3852	Histidine kinase
HT135_RS08045	COG2105	PFAM AIG2 family protein
HT135_RS08045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HT135_RS08050	COG0569	domain protein
HT135_RS08055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HT135_RS08060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HT135_RS08065	COG5503	Protein of unknown function (DUF1447)
HT135_RS08070	COG0561	phosphatase activity
HT135_RS08075	COG0242	peptide deformylase activity
HT135_RS08085	COG0497	DNA recombination
HT135_RS08090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_RS08095	COG0022	dehydrogenase e1 component
HT135_RS08100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_RS08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_RS08110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS08120	COG1982	Orn Lys Arg decarboxylase major
HT135_RS08125	COG4476	Belongs to the UPF0223 family
HT135_RS08130	COG4493	Belongs to the UPF0637 family
HT135_RS08140	COG0483	inositol monophosphate 1-phosphatase activity
HT135_RS08150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HT135_RS08190	COG1217	gtp-binding protein TYPA
HT135_RS08200	COG4896	Protein conserved in bacteria
HT135_RS08210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HT135_RS08215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HT135_RS08220	COG2066	Belongs to the glutaminase family
HT135_RS08225	COG4838	Belongs to the UPF0358 family
HT135_RS08230	COG0772	Belongs to the SEDS family
HT135_RS08235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HT135_RS08240	COG1612	heme a metabolic process
HT135_RS08245	COG0109	protoheme IX farnesyltransferase activity
HT135_RS08250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HT135_RS08250	COG2010	Cytochrome c
HT135_RS08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HT135_RS08260	COG1845	cytochrome c oxidase, subunit III
HT135_RS08265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HT135_RS08270	COG3336	cytochrome c oxidase
HT135_RS08280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HT135_RS08285	COG2340	Cysteine-rich secretory protein family
HT135_RS08300	COG3679	Belongs to the UPF0342 family
HT135_RS08305	COG4471	UPF0298 protein
HT135_RS08310	COG0742	ribosomal rna small subunit methyltransferase
HT135_RS08315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HT135_RS08320	COG3314	Sporulation integral membrane protein YlbJ
HT135_RS08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
HT135_RS08330	COG3480	Lon protease (S16) C-terminal proteolytic domain
HT135_RS08340	COG1323	Belongs to the UPF0348 family
HT135_RS08345	COG1399	metal-binding, possibly nucleic acid-binding protein
HT135_RS08360	COG0454	-acetyltransferase
HT135_RS08365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HT135_RS08370	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HT135_RS08375	COG2001	Belongs to the MraZ family
HT135_RS08380	COG0275	rRNA processing
HT135_RS08385	COG4839	cell division protein FtsL
HT135_RS08390	COG0768	penicillin binding
HT135_RS08395	COG0768	penicillin binding
HT135_RS08400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HT135_RS08405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HT135_RS08410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HT135_RS08415	COG0772	Belongs to the SEDS family
HT135_RS08420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_RS08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HT135_RS08430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HT135_RS08435	COG3879	Bacterial protein of unknown function (DUF881)
HT135_RS08440	COG3879	Bacterial protein of unknown function (DUF881)
HT135_RS08445	COG3856	small basic protein
HT135_RS08450	COG0849	cell division
HT135_RS08455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HT135_RS08460	COG1404	Belongs to the peptidase S8 family
HT135_RS08460	COG4412	M6 family metalloprotease domain protein
HT135_RS08470	COG1191	sigma factor activity
HT135_RS08475	COG1191	sigma factor activity
HT135_RS08480	COG1119	ATPase activity
HT135_RS08485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_RS08490	COG1873	PFAM PRC-barrel domain
HT135_RS08495	COG1496	oxidoreductase activity
HT135_RS08500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HT135_RS08505	COG1799	cell septum assembly
HT135_RS08510	COG0762	integral membrane protein
HT135_RS08515	COG2302	S4 RNA-binding domain
HT135_RS08520	COG3599	regulation of cell shape
HT135_RS08525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HT135_RS08530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_RS08535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HT135_RS08540	COG0564	pseudouridine synthase activity
HT135_RS08545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HT135_RS08550	COG2233	PERMEase
HT135_RS08555	COG0540	Belongs to the ATCase OTCase family
HT135_RS08560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HT135_RS08565	COG0505	Belongs to the CarA family
HT135_RS08570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HT135_RS08575	COG0543	2 iron, 2 sulfur cluster binding
HT135_RS08580	COG0167	dihydroorotate dehydrogenase activity
HT135_RS08585	COG0284	orotidine-5'-phosphate decarboxylase activity
HT135_RS08590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HT135_RS08595	COG0175	sulfate reduction
HT135_RS08600	COG0306	phosphate transporter
HT135_RS08605	COG2046	Belongs to the sulfate adenylyltransferase family
HT135_RS08610	COG0529	Catalyzes the synthesis of activated sulfate
HT135_RS08615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HT135_RS08620	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HT135_RS08625	COG1648	precorrin-2 dehydrogenase activity
HT135_RS08630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HT135_RS08635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HT135_RS08640	COG1561	YicC-like family, N-terminal region
HT135_RS08650	COG0194	GDP metabolic process
HT135_RS08655	COG1758	RNA polymerase activity
HT135_RS08660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HT135_RS08665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HT135_RS08670	COG0242	peptide deformylase activity
HT135_RS08675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HT135_RS08680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HT135_RS08680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HT135_RS08685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HT135_RS08690	COG0631	protein serine/threonine phosphatase activity
HT135_RS08695	COG0515	serine threonine protein kinase
HT135_RS08695	COG2815	serine threonine protein kinase
HT135_RS08700	COG1162	GTPase activity
HT135_RS08705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT135_RS08710	COG1564	THIamine pyrophosphokinase
HT135_RS08720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HT135_RS08725	COG1302	Protein conserved in bacteria
HT135_RS08730	COG1461	Dihydroxyacetone kinase
HT135_RS08735	COG1760	l-serine dehydratase
HT135_RS08740	COG1760	l-serine dehydratase
HT135_RS08745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HT135_RS08750	COG2050	protein possibly involved in aromatic compounds catabolism
HT135_RS08750	COG1349	DNA-binding transcription factor activity
HT135_RS08755	COG0416	fatty acid biosynthetic process
HT135_RS08760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS08775	COG0571	ribonuclease III activity
HT135_RS08780	COG1196	nuclear chromosome segregation
HT135_RS08785	COG0552	protein localization to endoplasmic reticulum
HT135_RS08795	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HT135_RS08800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HT135_RS08805	COG0228	four-way junction DNA binding
HT135_RS08810	COG1837	Belongs to the UPF0109 family
HT135_RS08820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HT135_RS08825	COG0336	Belongs to the RNA methyltransferase TrmD family
HT135_RS08830	COG0335	large ribosomal subunit rRNA binding
HT135_RS08835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HT135_RS08840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HT135_RS08850	COG2257	FlhB HrpN YscU SpaS Family
HT135_RS08855	COG0045	succinate-CoA ligase (ADP-forming) activity
HT135_RS08860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT135_RS08865	COG0758	DNA mediated transformation
HT135_RS08870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT135_RS08875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HT135_RS08880	COG4974	Belongs to the 'phage' integrase family
HT135_RS08885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HT135_RS08890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HT135_RS08895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HT135_RS08900	COG1815	bacterial-type flagellum-dependent cell motility
HT135_RS08905	COG1558	bacterial-type flagellum-dependent cell motility
HT135_RS08910	COG1677	Flagellar hook-basal body complex protein FliE
HT135_RS08915	COG1766	The M ring may be actively involved in energy transduction
HT135_RS08920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_RS08925	COG1317	bacterial-type flagellum organization
HT135_RS08930	COG1157	protein secretion by the type III secretion system
HT135_RS08935	COG2882	bacterial-type flagellum organization
HT135_RS08940	COG3334	PFAM MgtE intracellular
HT135_RS08945	COG3144	bacterial-type flagellum assembly
HT135_RS08950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HT135_RS08955	COG4786	Flagellar basal body rod
HT135_RS08960	COG1582	Flagellar protein (FlbD)
HT135_RS08965	COG1580	Controls the rotational direction of flagella during chemotaxis
HT135_RS08970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_RS08975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_RS08975	COG1776	CheC inhibitor of MCP methylation
HT135_RS08980	COG2201	protein-glutamate methylesterase activity
HT135_RS08985	COG3190	flagellar
HT135_RS08990	COG1338	Plays a role in the flagellum-specific transport system
HT135_RS08995	COG1987	bacterial-type flagellum assembly
HT135_RS09000	COG1684	flagellar biosynthetic protein fliR
HT135_RS09005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT135_RS09010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT135_RS09015	COG1419	protein localization to endoplasmic reticulum
HT135_RS09020	COG0455	bacterial-type flagellum organization
HT135_RS09025	COG2201	protein-glutamate methylesterase activity
HT135_RS09030	COG0643	Histidine kinase
HT135_RS09030	COG2198	Histidine kinase
HT135_RS09035	COG0835	chemotaxis
HT135_RS09040	COG1776	CheC inhibitor of MCP methylation
HT135_RS09045	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HT135_RS09050	COG1191	sigma factor activity
HT135_RS09060	COG0052	Belongs to the universal ribosomal protein uS2 family
HT135_RS09065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HT135_RS09070	COG0528	UMP kinase activity
HT135_RS09075	COG0233	cytoplasmic translational termination
HT135_RS09080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HT135_RS09085	COG4589	Belongs to the CDS family
HT135_RS09090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HT135_RS09095	COG0750	zinc metalloprotease
HT135_RS09100	COG0442	prolyl-tRNA aminoacylation
HT135_RS09105	COG2176	DNA-directed DNA polymerase activity
HT135_RS09110	COG0779	Required for maturation of 30S ribosomal subunits
HT135_RS09115	COG0195	Participates in both transcription termination and antitermination
HT135_RS09120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HT135_RS09125	COG1358	cellular component organization or biogenesis
HT135_RS09130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HT135_RS09135	COG1550	Protein conserved in bacteria
HT135_RS09140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HT135_RS09145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HT135_RS09150	COG0196	riboflavin kinase activity
HT135_RS09160	COG1185	polyribonucleotide nucleotidyltransferase activity
HT135_RS09165	COG0726	polysaccharide deacetylase
HT135_RS09170	COG0612	Peptidase, M16
HT135_RS09175	COG1873	PFAM PRC-barrel domain
HT135_RS09180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT135_RS09185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HT135_RS09190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HT135_RS09195	COG0527	aspartate kinase activity
HT135_RS09200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HT135_RS09205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HT135_RS09210	COG0740	serine-type endopeptidase activity
HT135_RS09220	COG1674	ftsk spoiiie
HT135_RS09220	COG4980	gas vesicle protein
HT135_RS09225	COG2188	Transcriptional regulator
HT135_RS09230	COG2814	Major facilitator Superfamily
HT135_RS09235	COG0612	Peptidase, M16
HT135_RS09240	COG0612	Peptidase, M16
HT135_RS09245	COG0300	oxidoreductase activity
HT135_RS09260	COG1426	Protein conserved in bacteria
HT135_RS09265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HT135_RS09270	COG1058	Belongs to the CinA family
HT135_RS09270	COG1546	Belongs to the CinA family
HT135_RS09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HT135_RS09280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_RS09285	COG1418	mRNA catabolic process
HT135_RS09290	COG1692	metallophosphoesterase
HT135_RS09295	COG2359	stage V sporulation protein S
HT135_RS09300	COG1063	alcohol dehydrogenase
HT135_RS09305	COG0156	8-amino-7-oxononanoate synthase activity
HT135_RS09310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HT135_RS09315	COG4550	Control of competence regulator ComK, YlbF/YmcA
HT135_RS09325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HT135_RS09330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HT135_RS09365	COG4195	phage-related replication protein
HT135_RS09375	COG0582	viral genome integration into host DNA
HT135_RS09400	COG3226	Transcriptional regulator
HT135_RS09405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS09410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_RS09415	COG3321	synthase
HT135_RS09420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_RS09420	COG2070	2-Nitropropane dioxygenase
HT135_RS09425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_RS09430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_RS09435	COG3425	synthase
HT135_RS09440	COG1024	Enoyl-CoA hydratase
HT135_RS09445	COG1024	Enoyl-CoA hydratase
HT135_RS09450	COG0300	oxidoreductase activity
HT135_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS09450	COG3321	synthase
HT135_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS09450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS09455	COG0300	oxidoreductase activity
HT135_RS09455	COG3321	synthase
HT135_RS09455	COG4221	oxidoreductase activity
HT135_RS09455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_RS09460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_RS09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS09460	COG3321	synthase
HT135_RS09460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_RS09465	COG3321	synthase
HT135_RS09465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS09465	COG4221	oxidoreductase activity
HT135_RS09470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HT135_RS09470	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HT135_RS09470	COG3321	synthase
HT135_RS09470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_RS09475	COG2124	cytochrome p450
HT135_RS09485	COG1404	Belongs to the peptidase S8 family
HT135_RS09490	COG4195	phage-related replication protein
HT135_RS09495	COG1764	response to oxidative stress
HT135_RS09520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HT135_RS09525	COG1923	regulation of RNA biosynthetic process
HT135_RS09545	COG1780	Probably involved in ribonucleotide reductase function
HT135_RS09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_RS09555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_RS09560	COG4112	unkown
HT135_RS09565	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS09570	COG0464	growth
HT135_RS09575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HT135_RS09580	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HT135_RS09585	COG0789	Transcriptional regulator
HT135_RS09590	COG0174	glutamine synthetase
HT135_RS09595	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS09595	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS09595	COG1388	LysM domain
HT135_RS09605	COG5444	nuclease activity
HT135_RS09610	COG0457	Tetratricopeptide repeat
HT135_RS09620	COG0456	acetyltransferase
HT135_RS09655	COG2273	Hydrolase Family 16
HT135_RS09665	COG0457	Tetratricopeptide repeat
HT135_RS09695	COG0726	polysaccharide deacetylase
HT135_RS09720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT135_RS09725	COG2720	vancomycin resistance protein
HT135_RS09730	COG3739	integral membrane protein
HT135_RS09735	COG3655	Transcriptional regulator
HT135_RS09745	COG2135	peptidase activity
HT135_RS09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_RS09770	COG3832	glyoxalase III activity
HT135_RS09800	COG4195	phage-related replication protein
HT135_RS09820	COG0346	lactoylglutathione lyase activity
HT135_RS09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HT135_RS09835	COG1388	LysM domain
HT135_RS09840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT135_RS09845	COG4224	UPF0291 protein
HT135_RS09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HT135_RS09860	COG3763	UPF0154 protein
HT135_RS09870	COG0785	Cytochrome C biogenesis protein
HT135_RS09875	COG2201	protein-glutamate methylesterase activity
HT135_RS09880	COG4846	Membrane protein involved in cytochrome C biogenesis
HT135_RS09890	COG0071	Belongs to the small heat shock protein (HSP20) family
HT135_RS09905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HT135_RS09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS09930	COG0824	Thioesterase
HT135_RS09940	COG4841	protein insertion into membrane
HT135_RS09945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HT135_RS09950	COG1832	CoA-binding protein
HT135_RS09955	COG0187	DNA topoisomerase II activity
HT135_RS09960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT135_RS09970	COG1115	amino acid carrier protein
HT135_RS09975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HT135_RS09990	COG5520	Belongs to the glycosyl hydrolase 30 family
HT135_RS09995	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_RS10000	COG2246	polysaccharide biosynthetic process
HT135_RS10010	COG0586	Pfam SNARE associated Golgi protein
HT135_RS10015	COG2404	hydrolase activity, acting on ester bonds
HT135_RS10020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HT135_RS10025	COG1024	Enoyl-CoA hydratase
HT135_RS10030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HT135_RS10035	COG0511	ligase activity, forming carbon-carbon bonds
HT135_RS10040	COG0439	Biotin carboxylase
HT135_RS10045	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS10050	COG1960	acyl-CoA dehydrogenase activity
HT135_RS10060	COG1649	PFAM Uncharacterised BCR, COG1649
HT135_RS10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS10070	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HT135_RS10075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS10080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS10085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS10090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS10095	COG2027	D-alanyl-D-alanine carboxypeptidase
HT135_RS10100	COG2017	converts alpha-aldose to the beta-anomer
HT135_RS10105	COG0534	Mate efflux family protein
HT135_RS10120	COG0582	viral genome integration into host DNA
HT135_RS10125	COG0166	Belongs to the GPI family
HT135_RS10130	COG0405	Gamma-glutamyltransferase
HT135_RS10135	COG0583	DNA-binding transcription factor activity
HT135_RS10140	COG0604	alcohol dehydrogenase
HT135_RS10145	COG0493	'glutamate synthase
HT135_RS10150	COG0070	glutamate synthase
HT135_RS10150	COG0069	glutamate synthase activity
HT135_RS10150	COG0067	glutamate synthase
HT135_RS10155	COG0583	DNA-binding transcription factor activity
HT135_RS10160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HT135_RS10180	COG0300	oxidoreductase activity
HT135_RS10185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HT135_RS10195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS10210	COG1131	(ABC) transporter
HT135_RS10220	COG2814	Major facilitator Superfamily
HT135_RS10225	COG1070	Carbohydrate kinase
HT135_RS10230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HT135_RS10235	COG0243	molybdopterin cofactor binding
HT135_RS10245	COG0673	inositol 2-dehydrogenase activity
HT135_RS10250	COG1082	Xylose isomerase domain protein TIM barrel
HT135_RS10255	COG1609	Transcriptional regulator
HT135_RS10260	COG4305	rare lipoprotein A
HT135_RS10265	COG3619	membrane
HT135_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS10310	COG2814	Major facilitator Superfamily
HT135_RS10315	COG1525	nuclease
HT135_RS10320	COG1231	oxidoreductase activity
HT135_RS10330	COG1070	Carbohydrate kinase
HT135_RS10345	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_RS10350	COG2211	Major facilitator Superfamily
HT135_RS10365	COG3397	chitin binding
HT135_RS10370	COG2318	DinB family
HT135_RS10375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_RS10455	COG0457	Tetratricopeptide repeat
HT135_RS10470	COG0574	Belongs to the PEP-utilizing enzyme family
HT135_RS10470	COG3848	Pyruvate phosphate dikinase
HT135_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS10500	COG1733	regulation of RNA biosynthetic process
HT135_RS10510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_RS10515	COG0662	Cupin 2, conserved barrel domain protein
HT135_RS10515	COG2207	Transcriptional regulator
HT135_RS10520	COG0456	acetyltransferase
HT135_RS10525	COG1309	transcriptional regulator
HT135_RS10530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS10535	COG3708	Transcriptional regulator
HT135_RS10540	COG2378	regulation of single-species biofilm formation
HT135_RS10550	COG0640	Transcriptional regulator
HT135_RS10555	COG0741	lytic transglycosylase activity
HT135_RS10560	COG2322	membrane
HT135_RS10575	COG1619	proteins homologs of microcin C7 resistance protein MccF
HT135_RS10580	COG3239	Fatty acid desaturase
HT135_RS10585	COG4585	Histidine kinase
HT135_RS10590	COG2197	response regulator
HT135_RS10600	COG1388	LysM domain
HT135_RS10600	COG3584	3D domain protein
HT135_RS10605	COG0514	ATP-dependent DNA helicase (RecQ)
HT135_RS10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HT135_RS10620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_RS10635	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS10640	COG1657	PFAM Prenyltransferase squalene oxidase
HT135_RS10645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT135_RS10650	COG0733	neurotransmitter:sodium symporter activity
HT135_RS10655	COG0385	Bile acid
HT135_RS10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_RS10665	COG0567	Dehydrogenase, E1 component
HT135_RS10670	COG4548	von Willebrand factor, type A
HT135_RS10675	COG0714	Associated with various cellular activities
HT135_RS10680	COG2032	superoxide dismutase activity
HT135_RS10685	COG0791	NLP P60 protein
HT135_RS10685	COG1388	LysM domain
HT135_RS10690	COG1819	glycosyl
HT135_RS10695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HT135_RS10700	COG0534	Mate efflux family protein
HT135_RS10705	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS10710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_RS10715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_RS10725	COG2962	Rard protein
HT135_RS10745	COG1942	4-Oxalocrotonate Tautomerase
HT135_RS10755	COG1733	regulation of RNA biosynthetic process
HT135_RS10760	COG0778	Nitroreductase
HT135_RS10765	COG0400	carboxylic ester hydrolase activity
HT135_RS10770	COG0346	lactoylglutathione lyase activity
HT135_RS10780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_RS10785	COG0793	Belongs to the peptidase S41A family
HT135_RS10785	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS10790	COG2226	methyltransferase
HT135_RS10800	COG1876	peptidase activity
HT135_RS10805	COG0813	purine-nucleoside phosphorylase activity
HT135_RS10820	COG0671	phosphoesterase, PA-phosphatase related
HT135_RS10840	COG4479	Belongs to the UPF0346 family
HT135_RS10850	COG1509	lysine 2,3-aminomutase activity
HT135_RS10855	COG0456	acetyltransferase
HT135_RS10860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_RS10865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HT135_RS10870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HT135_RS10875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_RS10885	COG0456	acetyltransferase
HT135_RS10890	COG0463	Glycosyl transferase, family 2
HT135_RS10905	COG4641	Protein conserved in bacteria
HT135_RS10910	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HT135_RS10915	COG1086	Polysaccharide biosynthesis protein
HT135_RS10925	COG3331	DNA recombination
HT135_RS10990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HT135_RS11010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_RS11015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HT135_RS11040	COG0756	dUTP diphosphatase activity
HT135_RS11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS11055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_RS11060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_RS11060	COG1372	Participates in initiation and elongation during chromosome replication
HT135_RS11070	COG1372	Participates in initiation and elongation during chromosome replication
HT135_RS11070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_RS11075	COG1780	Probably involved in ribonucleotide reductase function
HT135_RS11170	COG0270	DNA (cytosine-5-)-methyltransferase activity
HT135_RS11185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT135_RS11210	COG3584	3D domain protein
HT135_RS11215	COG0587	DNA-directed DNA polymerase activity
HT135_RS11220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HT135_RS11225	COG0358	DNA primase activity
HT135_RS11230	COG0305	Participates in initiation and elongation during chromosome replication
HT135_RS11240	COG2887	Belongs to the helicase family. UvrD subfamily
HT135_RS11265	COG3420	alginic acid biosynthetic process
HT135_RS11265	COG5434	Belongs to the glycosyl hydrolase 28 family
HT135_RS11270	COG4195	phage-related replication protein
HT135_RS11290	COG2135	peptidase activity
HT135_RS11295	COG1793	dna ligase
HT135_RS11370	COG3655	Transcriptional regulator
HT135_RS11385	COG0582	viral genome integration into host DNA
HT135_RS11465	COG3655	Transcriptional regulator
HT135_RS11540	COG1395	domain, Protein
HT135_RS11555	COG0776	regulation of translation
HT135_RS11590	COG4373	Mu-like prophage FluMu protein gp28
HT135_RS11690	COG0582	viral genome integration into host DNA
HT135_RS11705	COG0739	heme binding
HT135_RS11705	COG0741	lytic transglycosylase activity
HT135_RS11705	COG1196	nuclear chromosome segregation
HT135_RS11715	COG2433	Pfam Transposase IS66
HT135_RS11730	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS11745	COG0457	Tetratricopeptide repeat
HT135_RS11750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_RS11775	COG5444	nuclease activity
HT135_RS11780	COG4282	regulation of fungal-type cell wall biogenesis
HT135_RS11790	COG1525	nuclease
HT135_RS11810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT135_RS11815	COG1086	Polysaccharide biosynthesis protein
HT135_RS11825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HT135_RS11830	COG1846	Transcriptional regulator
HT135_RS11835	COG0534	Mate efflux family protein
HT135_RS11845	COG4698	Protein conserved in bacteria
HT135_RS11850	COG2755	lipolytic protein G-D-S-L family
HT135_RS11855	COG1999	signal sequence binding
HT135_RS11865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HT135_RS11870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HT135_RS11875	COG1272	protein, Hemolysin III
HT135_RS11880	COG0204	Acyl-transferase
HT135_RS11885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_RS11895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HT135_RS11905	COG2136	Putative SAM-dependent methyltransferase
HT135_RS11905	COG2521	methyltransferase
HT135_RS11915	COG0129	dihydroxy-acid dehydratase activity
HT135_RS11920	COG1413	lyase activity
HT135_RS11925	COG1418	mRNA catabolic process
HT135_RS11930	COG0386	Belongs to the glutathione peroxidase family
HT135_RS11935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HT135_RS11940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_RS11945	COG1278	Cold shock
HT135_RS11965	COG0328	RNA-DNA hybrid ribonuclease activity
HT135_RS11970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HT135_RS11975	COG0328	RNA-DNA hybrid ribonuclease activity
HT135_RS11985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_RS12000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HT135_RS12010	COG1755	Isoprenylcysteine carboxyl methyltransferase
HT135_RS12015	COG3424	synthase
HT135_RS12020	COG2233	PERMEase
HT135_RS12025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_RS12030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HT135_RS12040	COG0800	Aldolase
HT135_RS12045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_RS12050	COG1609	Transcriptional regulator
HT135_RS12055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HT135_RS12060	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS12065	COG1199	ATP-dependent helicase activity
HT135_RS12080	COG0116	Belongs to the methyltransferase superfamily
HT135_RS12095	COG4474	Belongs to the UPF0398 family
HT135_RS12110	COG3359	exonuclease
HT135_RS12115	COG1111	helicase
HT135_RS12115	COG1205	dead DEAH box helicase
HT135_RS12120	COG2190	(PTS) system
HT135_RS12125	COG0071	Belongs to the small heat shock protein (HSP20) family
HT135_RS12160	COG3331	DNA recombination
HT135_RS12165	COG4499	WXG100 protein secretion system (Wss), protein YukC
HT135_RS12165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_RS12175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HT135_RS12180	COG3935	DnaD domain protein
HT135_RS12185	COG0017	Asparaginyl-tRNA synthetase
HT135_RS12190	COG0436	Aminotransferase
HT135_RS12195	COG5353	protein conserved in bacteria
HT135_RS12205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HT135_RS12205	COG1199	ATP-dependent helicase activity
HT135_RS12210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HT135_RS12215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HT135_RS12220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HT135_RS12225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HT135_RS12225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HT135_RS12230	COG0617	tRNA 3'-terminal CCA addition
HT135_RS12235	COG0438	transferase activity, transferring glycosyl groups
HT135_RS12240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_RS12245	COG1803	Methylglyoxal synthase
HT135_RS12250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HT135_RS12255	COG1694	Mazg nucleotide pyrophosphohydrolase
HT135_RS12260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS12270	COG4347	Protein of unknown function (DUF1405)
HT135_RS12275	COG2010	Cytochrome c
HT135_RS12275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HT135_RS12280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HT135_RS12285	COG0723	plastoquinol--plastocyanin reductase activity
HT135_RS12295	COG5582	Belongs to the UPF0302 family
HT135_RS12300	COG0457	Tetratricopeptide repeat
HT135_RS12305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HT135_RS12310	COG0287	Prephenate dehydrogenase
HT135_RS12315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HT135_RS12320	COG0159	tryptophan synthase activity
HT135_RS12325	COG0133	tryptophan synthase activity
HT135_RS12330	COG0135	phosphoribosylanthranilate isomerase activity
HT135_RS12340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HT135_RS12345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT135_RS12350	COG4401	Chorismate mutase type I
HT135_RS12355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HT135_RS12360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HT135_RS12365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HT135_RS12370	COG0105	UTP biosynthetic process
HT135_RS12375	COG0142	geranyltranstransferase activity
HT135_RS12380	COG2226	methyltransferase
HT135_RS12385	COG0142	geranyltranstransferase activity
HT135_RS12395	COG0302	gtp cyclohydrolase
HT135_RS12400	COG0776	regulation of translation
HT135_RS12405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HT135_RS12420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HT135_RS12425	COG1160	GTP binding
HT135_RS12450	COG1304	FMN binding
HT135_RS12455	COG0539	negative regulation of cytoplasmic translation
HT135_RS12460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HT135_RS12475	COG2959	enzyme of heme biosynthesis
HT135_RS12480	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS12480	COG3773	Cell wall hydrolase
HT135_RS12485	COG2339	peptidase activity
HT135_RS12490	COG0492	ferredoxin-NADP+ reductase activity
HT135_RS12495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_RS12500	COG4862	establishment of competence for transformation
HT135_RS12505	COG1408	metallophosphoesterase
HT135_RS12515	COG1388	LysM domain
HT135_RS12520	COG1266	CAAX protease self-immunity
HT135_RS12525	COG0514	ATP-dependent DNA helicase (RecQ)
HT135_RS12530	COG4955	Helix-turn-helix domain
HT135_RS12535	COG1141	Ferredoxin
HT135_RS12540	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HT135_RS12545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HT135_RS12550	COG0710	3-dehydroquinate dehydratase activity
HT135_RS12560	COG1595	DNA-templated transcription, initiation
HT135_RS12565	COG5002	protein histidine kinase activity
HT135_RS12570	COG0745	RESPONSE REGULATOR receiver
HT135_RS12575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT135_RS12580	COG1333	cytochrome c biogenesis protein
HT135_RS12585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS12590	COG1187	pseudouridine synthase activity
HT135_RS12595	COG0700	Nucleoside recognition
HT135_RS12600	COG2715	membrane protein required for spore maturation
HT135_RS12605	COG1686	Belongs to the peptidase S11 family
HT135_RS12615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HT135_RS12620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HT135_RS12630	COG1547	Domain of unknown function (DUF309)
HT135_RS12635	COG0456	acetyltransferase
HT135_RS12640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HT135_RS12645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HT135_RS12645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HT135_RS12650	COG0307	riboflavin synthase, alpha
HT135_RS12655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT135_RS12655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT135_RS12665	COG0681	Belongs to the peptidase S26 family
HT135_RS12670	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HT135_RS12675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HT135_RS12680	COG4086	secreted protein
HT135_RS12685	COG0019	diaminopimelate decarboxylase activity
HT135_RS12690	COG0697	spore germination
HT135_RS12705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_RS12725	COG1191	sigma factor activity
HT135_RS12730	COG2172	sigma factor antagonist activity
HT135_RS12735	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS12740	COG1686	Belongs to the peptidase S11 family
HT135_RS12745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HT135_RS12750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HT135_RS12755	COG4974	Belongs to the 'phage' integrase family
HT135_RS12765	COG0735	belongs to the Fur family
HT135_RS12770	COG1300	Membrane
HT135_RS12780	COG0281	malic enzyme
HT135_RS12785	COG1757	Na H antiporter
HT135_RS12790	COG1027	Aspartate ammonia-lyase
HT135_RS12795	COG0252	asparaginase activity
HT135_RS12800	COG1396	sequence-specific DNA binding
HT135_RS12805	COG1379	DNA repair
HT135_RS12810	COG0494	nUDIX hydrolase
HT135_RS12820	COG0667	Aldo Keto reductase
HT135_RS12830	COG1073	alpha beta
HT135_RS12840	COG4918	Iron-sulphur cluster biosynthesis
HT135_RS12845	COG0456	acetyltransferase
HT135_RS12845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HT135_RS12850	COG2329	Antibiotic biosynthesis monooxygenase
HT135_RS12855	COG0456	acetyltransferase
HT135_RS12865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_RS12875	COG2211	Major facilitator Superfamily
HT135_RS12885	COG0346	lactoylglutathione lyase activity
HT135_RS12890	COG1072	(Pantothenic acid kinase))
HT135_RS12895	COG3048	D-serine ammonia-lyase activity
HT135_RS12900	COG0300	oxidoreductase activity
HT135_RS12905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS12910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_RS12915	COG4187	Peptidase family M20/M25/M40
HT135_RS12920	COG1902	pentaerythritol trinitrate reductase activity
HT135_RS12925	COG0596	Alpha beta hydrolase
HT135_RS12935	COG1234	tRNA 3'-trailer cleavage
HT135_RS12940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HT135_RS12950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HT135_RS12955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_RS12965	COG0706	membrane insertase activity
HT135_RS12975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT135_RS12980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HT135_RS12985	COG0346	lactoylglutathione lyase activity
HT135_RS12995	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_RS13000	COG4129	membrane
HT135_RS13005	COG1126	abc transporter atp-binding protein
HT135_RS13010	COG0765	amino acid transport
HT135_RS13015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS13025	COG1597	lipid kinase activity
HT135_RS13030	COG2814	Major facilitator Superfamily
HT135_RS13035	COG0789	Transcriptional regulator
HT135_RS13035	COG4978	Transcriptional regulator
HT135_RS13040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_RS13045	COG0022	dehydrogenase e1 component
HT135_RS13050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_RS13055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_RS13060	COG3426	butyrate kinase activity
HT135_RS13065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_RS13070	COG0280	phosphate acetyltransferase
HT135_RS13075	COG3290	protein histidine kinase activity
HT135_RS13075	COG3829	transcription factor binding
HT135_RS13085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HT135_RS13090	COG2079	MmgE PrpD family protein
HT135_RS13095	COG0372	Belongs to the citrate synthase family
HT135_RS13100	COG1960	acyl-CoA dehydrogenase activity
HT135_RS13105	COG1250	3-hydroxyacyl-CoA dehydrogenase
HT135_RS13110	COG0183	Belongs to the thiolase family
HT135_RS13115	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_RS13120	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS13135	COG1902	pentaerythritol trinitrate reductase activity
HT135_RS13140	COG0745	RESPONSE REGULATOR receiver
HT135_RS13145	COG0750	zinc metalloprotease
HT135_RS13150	COG0497	DNA recombination
HT135_RS13155	COG1438	arginine binding
HT135_RS13160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HT135_RS13165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HT135_RS13170	COG0142	geranyltranstransferase activity
HT135_RS13175	COG1722	exodeoxyribonuclease VII activity
HT135_RS13180	COG1570	exodeoxyribonuclease VII activity
HT135_RS13185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HT135_RS13190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HT135_RS13195	COG1302	Protein conserved in bacteria
HT135_RS13200	COG0439	Biotin carboxylase
HT135_RS13205	COG0511	ligase activity, forming carbon-carbon bonds
HT135_RS13245	COG3854	ATPases associated with a variety of cellular activities
HT135_RS13255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HT135_RS13260	COG0006	proline dipeptidase activity
HT135_RS13265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HT135_RS13275	COG3872	metal-dependent enzyme
HT135_RS13285	COG1752	Esterase of the alpha-beta hydrolase superfamily
HT135_RS13290	COG1321	iron dependent repressor
HT135_RS13295	COG0095	Lipoate-protein ligase
HT135_RS13300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT135_RS13305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HT135_RS13310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HT135_RS13315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HT135_RS13320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HT135_RS13335	COG1396	sequence-specific DNA binding
HT135_RS13345	COG0681	Belongs to the peptidase S26 family
HT135_RS13370	COG4940	Competence protein ComGF
HT135_RS13380	COG4970	Tfp pilus assembly protein FimT
HT135_RS13385	COG4537	Required for transformation and DNA binding
HT135_RS13390	COG1459	type II secretion system
HT135_RS13395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HT135_RS13400	COG0517	IMP dehydrogenase activity
HT135_RS13405	COG0598	Magnesium transport protein CorA
HT135_RS13410	COG1253	flavin adenine dinucleotide binding
HT135_RS13415	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS13425	COG1393	Belongs to the ArsC family
HT135_RS13435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS13445	COG0011	TIGRFAM Protein of
HT135_RS13455	COG2866	Carboxypeptidase
HT135_RS13460	COG1368	sulfuric ester hydrolase activity
HT135_RS13465	COG1940	carbohydrate kinase activity
HT135_RS13470	COG4483	Protein conserved in bacteria
HT135_RS13475	COG0457	Tetratricopeptide repeat
HT135_RS13475	COG0705	Rhomboid family
HT135_RS13485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HT135_RS13495	COG0438	transferase activity, transferring glycosyl groups
HT135_RS13510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HT135_RS13515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_RS13520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_RS13525	COG0581	inorganic phosphate transmembrane transporter activity
HT135_RS13530	COG0573	inorganic phosphate transmembrane transporter activity
HT135_RS13535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HT135_RS13540	COG0768	penicillin binding
HT135_RS13545	COG0477	Major facilitator Superfamily
HT135_RS13550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT135_RS13555	COG2839	Protein conserved in bacteria
HT135_RS13560	COG5521	maltodextrose utilization protein MalA
HT135_RS13565	COG1388	LysM domain
HT135_RS13570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HT135_RS13575	COG4709	membrane
HT135_RS13580	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HT135_RS13585	COG0735	belongs to the Fur family
HT135_RS13590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS13600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HT135_RS13605	COG0513	Belongs to the DEAD box helicase family
HT135_RS13615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HT135_RS13620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HT135_RS13625	COG2384	SAM-dependent methyltransferase
HT135_RS13630	COG2010	Cytochrome c
HT135_RS13635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HT135_RS13640	COG0358	DNA primase activity
HT135_RS13645	COG1671	Belongs to the UPF0178 family
HT135_RS13650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HT135_RS13655	COG0517	IMP dehydrogenase activity
HT135_RS13660	COG0751	glycine-tRNA ligase activity
HT135_RS13665	COG0752	glycyl-tRNA synthetase alpha subunit
HT135_RS13670	COG1381	Involved in DNA repair and RecF pathway recombination
HT135_RS13680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HT135_RS13685	COG0295	cytidine deaminase activity
HT135_RS13690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HT135_RS13695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HT135_RS13700	COG1480	7TM receptor with intracellular HD hydrolase
HT135_RS13705	COG1702	phosphate starvation-inducible protein PhoH
HT135_RS13710	COG0561	phosphatase activity
HT135_RS13725	COG4864	UPF0365 protein
HT135_RS13730	COG1030	water channel activity
HT135_RS13735	COG1610	YqeY-like protein
HT135_RS13745	COG1283	sodium-dependent phosphate transmembrane transporter activity
HT135_RS13750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HT135_RS13755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HT135_RS13760	COG2264	protein methyltransferase activity
HT135_RS13765	COG0484	heat shock protein binding
HT135_RS13775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HT135_RS13780	COG1420	regulation of RNA biosynthetic process
HT135_RS13785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT135_RS13790	COG0481	GTPase activity
HT135_RS13800	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS13805	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HT135_RS13815	COG1466	dna polymerase III delta subunit
HT135_RS13830	COG2333	competence protein COMEC
HT135_RS13830	COG0658	competence protein
HT135_RS13835	COG2131	deaminase
HT135_RS13840	COG1555	photosystem II stabilization
HT135_RS13840	COG1596	polysaccharide export
HT135_RS13845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_RS13850	COG2226	methyltransferase
HT135_RS13855	COG0799	negative regulation of ribosome biogenesis
HT135_RS13860	COG1713	HD superfamily hydrolase involved in NAD metabolism
HT135_RS13865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HT135_RS13870	COG1534	Rna-binding protein
HT135_RS13875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HT135_RS13880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HT135_RS13885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HT135_RS13895	COG2755	lipolytic protein G-D-S-L family
HT135_RS13900	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS13900	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS13905	COG0398	Pfam SNARE associated Golgi protein
HT135_RS13910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HT135_RS13920	COG3209	COG3209 Rhs family protein
HT135_RS13955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_RS13970	COG2814	Major facilitator Superfamily
HT135_RS13975	COG0457	Tetratricopeptide repeat
HT135_RS13980	COG2072	flavoprotein involved in K transport
HT135_RS13985	COG1230	cation diffusion facilitator family transporter
HT135_RS14005	COG5444	nuclease activity
HT135_RS14015	COG0697	spore germination
HT135_RS14020	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS14020	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_RS14025	COG4824	toxin secretion phage lysis holin
HT135_RS14085	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HT135_RS14105	COG0563	adenylate kinase activity
HT135_RS14125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HT135_RS14130	COG1733	regulation of RNA biosynthetic process
HT135_RS14165	COG2732	(Barnase) inhibitor
HT135_RS14195	COG1725	Transcriptional regulator
HT135_RS14210	COG0747	negative chemotaxis
HT135_RS14215	COG0601	transmembrane transport
HT135_RS14220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_RS14225	COG0444	Belongs to the ABC transporter superfamily
HT135_RS14230	COG4608	Belongs to the ABC transporter superfamily
HT135_RS14240	COG3443	Belongs to the bacterial solute-binding protein 9 family
HT135_RS14250	COG4991	sh3 domain protein
HT135_RS14255	COG4991	sh3 domain protein
HT135_RS14280	COG0789	Transcriptional regulator
HT135_RS14285	COG1064	alcohol dehydrogenase
HT135_RS14290	COG0693	protein deglycase activity
HT135_RS14295	COG1621	beta-fructofuranosidase activity
HT135_RS14300	COG3716	PTS system mannose fructose sorbose family IID component
HT135_RS14305	COG3715	PTS system
HT135_RS14310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS14315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS14320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HT135_RS14320	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HT135_RS14325	COG1113	amino acid transport
HT135_RS14330	COG1280	lysine exporter protein (LysE YggA)
HT135_RS14335	COG1378	Sugar-specific transcriptional regulator TrmB
HT135_RS14340	COG1595	DNA-templated transcription, initiation
HT135_RS14350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HT135_RS14350	COG2755	lipolytic protein G-D-S-L family
HT135_RS14360	COG2124	cytochrome p450
HT135_RS14360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_RS14365	COG1309	transcriptional regulator
HT135_RS14370	COG2226	methyltransferase
HT135_RS14385	COG2116	formate transmembrane transporter activity
HT135_RS14390	COG5609	conserved protein (DUF2294)
HT135_RS14395	COG3383	formate dehydrogenase (NAD+) activity
HT135_RS14400	COG2427	Protein of unknown function (DUF1641)
HT135_RS14410	COG0626	cystathionine gamma-synthase activity
HT135_RS14415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_RS14420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HT135_RS14425	COG2226	methyltransferase
HT135_RS14440	COG0768	penicillin binding
HT135_RS14445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HT135_RS14450	COG0572	uridine kinase
HT135_RS14455	COG0826	peptidase U32
HT135_RS14460	COG0826	peptidase U32
HT135_RS14465	COG4122	O-methyltransferase activity
HT135_RS14470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HT135_RS14475	COG3906	Belongs to the UPF0473 family
HT135_RS14480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HT135_RS14485	COG4472	Bacterial protein of unknown function (DUF965)
HT135_RS14490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HT135_RS14495	COG0628	permease
HT135_RS14500	COG1126	abc transporter atp-binding protein
HT135_RS14505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS14510	COG0765	amino acid transport
HT135_RS14515	COG0765	amino acid transport
HT135_RS14530	COG3881	PFAM PRC-barrel domain
HT135_RS14535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HT135_RS14540	COG0457	Tetratricopeptide repeat
HT135_RS14545	COG0482	sulfurtransferase activity
HT135_RS14550	COG1104	cysteine desulfurase activity
HT135_RS14555	COG1959	2 iron, 2 sulfur cluster binding
HT135_RS14560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HT135_RS14565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HT135_RS14575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HT135_RS14580	COG0124	histidyl-tRNA synthetase
HT135_RS14590	COG3103	Sh3 type 3 domain protein
HT135_RS14590	COG4991	sh3 domain protein
HT135_RS14590	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS14595	COG1490	D-aminoacyl-tRNA deacylase activity
HT135_RS14600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HT135_RS14605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_RS14610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HT135_RS14610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HT135_RS14615	COG5416	Lipopolysaccharide assembly protein A domain
HT135_RS14620	COG0490	domain, Protein
HT135_RS14625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT135_RS14625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT135_RS14635	COG2244	polysaccharide biosynthetic process
HT135_RS14640	COG2323	membrane
HT135_RS14650	COG1862	Preprotein translocase
HT135_RS14655	COG0343	queuine tRNA-ribosyltransferase activity
HT135_RS14660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HT135_RS14670	COG2255	four-way junction helicase activity
HT135_RS14675	COG0632	four-way junction helicase activity
HT135_RS14685	COG2814	Major facilitator Superfamily
HT135_RS14690	COG0673	inositol 2-dehydrogenase activity
HT135_RS14695	COG2112	serine threonine protein kinase
HT135_RS14710	COG1115	amino acid carrier protein
HT135_RS14715	COG0217	transcriptional regulatory protein
HT135_RS14725	COG1388	LysM domain
HT135_RS14730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HT135_RS14735	COG0157	Belongs to the NadC ModD family
HT135_RS14740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HT135_RS14745	COG1104	cysteine desulfurase activity
HT135_RS14750	COG1827	regulation of RNA biosynthetic process
HT135_RS14755	COG0077	Prephenate dehydratase
HT135_RS14760	COG4492	Belongs to the UPF0735 family
HT135_RS14765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HT135_RS14770	COG3290	protein histidine kinase activity
HT135_RS14780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HT135_RS14785	COG2868	ribosomal protein
HT135_RS14790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HT135_RS14795	COG1994	Peptidase M50
HT135_RS14800	COG0739	heme binding
HT135_RS14805	COG2894	cell division
HT135_RS14810	COG0850	regulation of cytokinetic process
HT135_RS14815	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HT135_RS14825	COG1077	Cell shape determining protein MreB Mrl
HT135_RS14830	COG2003	Belongs to the UPF0758 family
HT135_RS14835	COG0424	maF-like protein
HT135_RS14845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HT135_RS14850	COG0285	dihydrofolate synthase activity
HT135_RS14855	COG0525	valine-tRNA ligase activity
HT135_RS14865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_RS14870	COG1388	LysM domain
HT135_RS14875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HT135_RS14880	COG0113	porphobilinogen synthase activity
HT135_RS14885	COG1587	Uroporphyrinogen-III synthase
HT135_RS14890	COG0181	hydroxymethylbilane synthase activity
HT135_RS14895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT135_RS14900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HT135_RS14910	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HT135_RS14915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HT135_RS14920	COG1067	ATP-dependent peptidase activity
HT135_RS14920	COG0470	DNA polymerase III
HT135_RS14925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HT135_RS14930	COG0544	peptidyl-prolyl cis-trans isomerase activity
HT135_RS14935	COG0457	Tetratricopeptide repeat
HT135_RS14935	COG1477	protein flavinylation
HT135_RS14940	COG0066	3-isopropylmalate dehydratase activity
HT135_RS14945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HT135_RS14950	COG0473	3-isopropylmalate dehydrogenase activity
HT135_RS14955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HT135_RS14960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HT135_RS14965	COG0440	acetolactate synthase activity
HT135_RS14970	COG0028	Belongs to the TPP enzyme family
HT135_RS14980	COG0454	-acetyltransferase
HT135_RS14985	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HT135_RS14995	COG0622	Phosphoesterase
HT135_RS15000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HT135_RS15005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HT135_RS15010	COG5401	PFAM Sporulation and spore germination
HT135_RS15015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HT135_RS15020	COG1846	Transcriptional regulator
HT135_RS15025	COG2197	response regulator
HT135_RS15030	COG0824	Thioesterase
HT135_RS15035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HT135_RS15040	COG1053	succinate dehydrogenase
HT135_RS15045	COG2009	succinate dehydrogenase
HT135_RS15050	COG1719	4-vinyl reductase, 4VR
HT135_RS15055	COG0527	aspartate kinase activity
HT135_RS15065	COG0322	excinuclease ABC activity
HT135_RS15070	COG3118	belongs to the thioredoxin family
HT135_RS15075	COG3534	alpha-L-arabinofuranosidase
HT135_RS15080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HT135_RS15085	COG2086	electron transfer activity
HT135_RS15090	COG1024	Enoyl-CoA hydratase
HT135_RS15095	COG1309	transcriptional regulator
HT135_RS15100	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS15105	COG3766	membrane
HT135_RS15110	COG1193	negative regulation of DNA recombination
HT135_RS15115	COG1796	DNA polymerase
HT135_RS15115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HT135_RS15120	COG1286	toxin biosynthetic process
HT135_RS15125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HT135_RS15130	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HT135_RS15135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_RS15135	COG0072	phenylalanine-tRNA ligase activity
HT135_RS15140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HT135_RS15150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT135_RS15160	COG3835	regulator
HT135_RS15165	COG0277	FAD linked oxidase domain protein
HT135_RS15170	COG0247	lactate metabolic process
HT135_RS15175	COG0346	lactoylglutathione lyase activity
HT135_RS15180	COG1966	Carbon starvation protein
HT135_RS15195	COG1695	Transcriptional regulator
HT135_RS15200	COG3534	alpha-L-arabinofuranosidase
HT135_RS15205	COG0395	ABC-type sugar transport system, permease component
HT135_RS15210	COG1175	transmembrane transport
HT135_RS15215	COG1653	transport
HT135_RS15220	COG0371	Dehydrogenase
HT135_RS15225	COG0647	UMP catabolic process
HT135_RS15230	COG0235	Class ii aldolase
HT135_RS15235	COG1069	ribulokinase activity
HT135_RS15240	COG2160	L-arabinose isomerase activity
HT135_RS15245	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_RS15250	COG1363	Peptidase, m42
HT135_RS15260	COG3326	Membrane
HT135_RS15265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HT135_RS15270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HT135_RS15275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HT135_RS15285	COG1346	cytolysis
HT135_RS15290	COG1380	Effector of murein hydrolase LrgA
HT135_RS15295	COG3279	Response regulator of the LytR AlgR family
HT135_RS15300	COG3275	phosphorelay sensor kinase activity
HT135_RS15305	COG1011	Hydrolase
HT135_RS15310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HT135_RS15320	COG0398	Pfam SNARE associated Golgi protein
HT135_RS15325	COG1484	DNA-dependent DNA replication
HT135_RS15330	COG3611	Membrane attachment protein
HT135_RS15335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HT135_RS15340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HT135_RS15345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT135_RS15350	COG1733	regulation of RNA biosynthetic process
HT135_RS15355	COG2814	Major facilitator Superfamily
HT135_RS15360	COG0656	L-ascorbic acid biosynthetic process
HT135_RS15365	COG0237	dephospho-CoA kinase activity
HT135_RS15370	COG1971	Probably functions as a manganese efflux pump
HT135_RS15375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HT135_RS15380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_RS15380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_RS15385	COG5002	protein histidine kinase activity
HT135_RS15390	COG0745	RESPONSE REGULATOR receiver
HT135_RS15395	COG0039	L-malate dehydrogenase activity
HT135_RS15400	COG0538	isocitrate dehydrogenase activity
HT135_RS15405	COG0372	Belongs to the citrate synthase family
HT135_RS15410	COG2707	UPF0756 membrane protein
HT135_RS15415	COG0628	permease
HT135_RS15420	COG3030	protein affecting phage T7 exclusion by the F plasmid
HT135_RS15425	COG0469	pyruvate kinase activity
HT135_RS15430	COG0205	6-phosphofructokinase activity
HT135_RS15435	COG0825	malonyl-CoA metabolic process
HT135_RS15440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HT135_RS15445	COG0281	malic enzyme
HT135_RS15450	COG0587	DNA-directed DNA polymerase activity
HT135_RS15470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HT135_RS15480	COG4109	DRTGG domain
HT135_RS15485	COG0730	response to heat
HT135_RS15490	COG1473	amidohydrolase
HT135_RS15495	COG0196	riboflavin kinase activity
HT135_RS15500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS15505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HT135_RS15510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS15515	COG1126	abc transporter atp-binding protein
HT135_RS15520	COG0765	amino acid transport
HT135_RS15525	COG0765	amino acid transport
HT135_RS15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS15535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS15540	COG0454	-acetyltransferase
HT135_RS15545	COG0583	DNA-binding transcription factor activity
HT135_RS15550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HT135_RS15555	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS15560	COG0165	Argininosuccinate lyase
HT135_RS15565	COG0137	argininosuccinate synthase activity
HT135_RS15570	COG0521	Mo-molybdopterin cofactor biosynthetic process
HT135_RS15575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HT135_RS15580	COG0827	DNA restriction-modification system
HT135_RS15585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HT135_RS15590	COG3874	Sporulation protein YtfJ
HT135_RS15600	COG1714	RDD family
HT135_RS15605	COG0616	signal peptide processing
HT135_RS15610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HT135_RS15615	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HT135_RS15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT135_RS15630	COG0301	tRNA thio-modification
HT135_RS15635	COG1104	cysteine desulfurase activity
HT135_RS15640	COG1114	Component of the transport system for branched-chain amino acids
HT135_RS15645	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HT135_RS15650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HT135_RS15655	COG1309	transcriptional regulator
HT135_RS15660	COG1956	GAF domain-containing protein
HT135_RS15665	COG2203	Gaf domain
HT135_RS15665	COG2199	diguanylate cyclase activity
HT135_RS15675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HT135_RS15680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT135_RS15685	COG0454	-acetyltransferase
HT135_RS15690	COG0517	IMP dehydrogenase activity
HT135_RS15695	COG0123	including yeast histone deacetylase and acetoin utilization protein
HT135_RS15700	COG1360	Flagellar Motor Protein
HT135_RS15705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HT135_RS15710	COG1609	Transcriptional regulator
HT135_RS15715	COG1605	Chorismate mutase
HT135_RS15715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HT135_RS15720	COG3118	belongs to the thioredoxin family
HT135_RS15725	COG4980	gas vesicle protein
HT135_RS15730	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HT135_RS15735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HT135_RS15740	COG1674	ftsk spoiiie
HT135_RS15745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_RS15750	COG4848	Belongs to the UPF0354 family
HT135_RS15755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS15770	COG1363	Peptidase, m42
HT135_RS15775	COG5584	Small secreted protein
HT135_RS15780	COG0281	malic enzyme
HT135_RS15785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS15790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HT135_RS15800	COG0510	thiamine kinase activity
HT135_RS15805	COG1523	belongs to the glycosyl hydrolase 13 family
HT135_RS15810	COG1597	lipid kinase activity
HT135_RS15820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HT135_RS15825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_RS15830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_RS15835	COG2252	PERMEase
HT135_RS15840	COG4473	ABC transporter
HT135_RS15845	COG1131	(ABC) transporter
HT135_RS15850	COG1349	DNA-binding transcription factor activity
HT135_RS15855	COG1187	pseudouridine synthase activity
HT135_RS15860	COG2244	polysaccharide biosynthetic process
HT135_RS15865	COG2081	HI0933 family
HT135_RS15870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HT135_RS15880	COG5578	integral membrane protein
HT135_RS15885	COG0673	inositol 2-dehydrogenase activity
HT135_RS15890	COG1653	transport
HT135_RS15895	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HT135_RS15900	COG4209	transmembrane transport
HT135_RS15905	COG2207	Transcriptional regulator
HT135_RS15910	COG1653	transport
HT135_RS15915	COG0395	ABC-type sugar transport system, permease component
HT135_RS15920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_RS15925	COG2124	cytochrome p450
HT135_RS15930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HT135_RS15940	COG0156	8-amino-7-oxononanoate synthase activity
HT135_RS15945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_RS15955	COG1073	alpha beta
HT135_RS15960	COG1609	Transcriptional regulator
HT135_RS15965	COG1653	transport
HT135_RS15970	COG1175	transmembrane transport
HT135_RS15975	COG0395	ABC-type sugar transport system, permease component
HT135_RS15980	COG1486	melibiose metabolic process
HT135_RS15985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT135_RS15990	COG0495	leucyl-tRNA aminoacylation
HT135_RS16000	COG2202	Pas domain
HT135_RS16000	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_RS16005	COG2814	Major facilitator Superfamily
HT135_RS16010	COG2433	Pfam Transposase IS66
HT135_RS16015	COG0577	efflux transmembrane transporter activity
HT135_RS16020	COG1136	(ABC) transporter
HT135_RS16025	COG2205	protein histidine kinase activity
HT135_RS16030	COG0745	RESPONSE REGULATOR receiver
HT135_RS16035	COG0577	efflux transmembrane transporter activity
HT135_RS16040	COG1136	(ABC) transporter
HT135_RS16055	COG1131	(ABC) transporter
HT135_RS16060	COG1725	Transcriptional regulator
HT135_RS16075	COG1242	4 iron, 4 sulfur cluster binding
HT135_RS16080	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HT135_RS16090	COG2267	carboxylic ester hydrolase activity
HT135_RS16095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HT135_RS16100	COG1113	amino acid transport
HT135_RS16105	COG0367	asparagine synthase
HT135_RS16110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HT135_RS16115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HT135_RS16125	COG1506	peptidase
HT135_RS16130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HT135_RS16135	COG1116	anion transmembrane transporter activity
HT135_RS16140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT135_RS16145	COG0494	nUDIX hydrolase
HT135_RS16150	COG4824	toxin secretion phage lysis holin
HT135_RS16155	COG0783	Belongs to the Dps family
HT135_RS16170	COG1854	S-ribosylhomocysteine lyase activity
HT135_RS16175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HT135_RS16180	COG0288	reversible hydration of carbon dioxide
HT135_RS16185	COG0254	rRNA binding
HT135_RS16190	COG1271	oxidase subunit
HT135_RS16195	COG1294	oxidase, subunit
HT135_RS16205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_RS16210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_RS16210	COG1321	iron dependent repressor
HT135_RS16215	COG1121	(ABC) transporter
HT135_RS16220	COG0803	Belongs to the bacterial solute-binding protein 9 family
HT135_RS16225	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_RS16230	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_RS16235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HT135_RS16240	COG0596	Alpha beta hydrolase
HT135_RS16245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HT135_RS16250	COG1169	isochorismate synthase
HT135_RS16255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_RS16260	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HT135_RS16265	COG0058	SHG alpha-glucan phosphorylase activity
HT135_RS16270	COG0297	glycogen (starch) synthase activity
HT135_RS16275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HT135_RS16280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HT135_RS16285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HT135_RS16410	COG3859	Proton-coupled thiamine transporter YuaJ
HT135_RS16415	COG1247	-acetyltransferase
HT135_RS16420	COG2268	Band 7 protein
HT135_RS16425	COG1585	Membrane protein implicated in regulation of membrane protease activity
HT135_RS16430	COG2318	DinB family
HT135_RS16440	COG1454	alcohol dehydrogenase
HT135_RS16445	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS16450	COG1510	regulation of RNA biosynthetic process
HT135_RS16460	COG0569	domain protein
HT135_RS16465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HT135_RS16470	COG4682	membrane
HT135_RS16475	COG1705	Flagellar rod assembly protein muramidase FlgJ
HT135_RS16480	COG0477	Major facilitator Superfamily
HT135_RS16485	COG5553	Cysteine dioxygenase type I
HT135_RS16495	COG1968	undecaprenyl-diphosphatase activity
HT135_RS16500	COG0628	permease
HT135_RS16505	COG0673	inositol 2-dehydrogenase activity
HT135_RS16510	COG4806	L-rhamnose isomerase
HT135_RS16515	COG3254	rhamnose metabolic process
HT135_RS16520	COG1070	Carbohydrate kinase
HT135_RS16525	COG1349	DNA-binding transcription factor activity
HT135_RS16530	COG3347	Dehydrogenase
HT135_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS16535	COG0840	transmembrane signaling receptor activity
HT135_RS16540	COG0840	transmembrane signaling receptor activity
HT135_RS16545	COG0840	transmembrane signaling receptor activity
HT135_RS16550	COG0840	transmembrane signaling receptor activity
HT135_RS16565	COG2070	2-Nitropropane dioxygenase
HT135_RS16570	COG0432	Pfam Uncharacterised protein family UPF0047
HT135_RS16575	COG0366	Alpha amylase catalytic
HT135_RS16580	COG1253	flavin adenine dinucleotide binding
HT135_RS16585	COG2738	Putative neutral zinc metallopeptidase
HT135_RS16600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HT135_RS16615	COG0166	Belongs to the GPI family
HT135_RS16620	COG1979	alcohol dehydrogenase
HT135_RS16625	COG1979	alcohol dehydrogenase
HT135_RS16630	COG2155	Conserved Protein
HT135_RS16635	COG1098	S1 RNA binding domain
HT135_RS16640	COG0436	Aminotransferase
HT135_RS16645	COG1522	sequence-specific DNA binding
HT135_RS16650	COG2267	carboxylic ester hydrolase activity
HT135_RS16660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HT135_RS16665	COG2205	protein histidine kinase activity
HT135_RS16675	COG5018	Exonuclease
HT135_RS16680	COG2814	Major facilitator Superfamily
HT135_RS16685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_RS16690	COG3011	Protein conserved in bacteria
HT135_RS16700	COG3290	protein histidine kinase activity
HT135_RS16705	COG4565	transcriptional regulatory protein
HT135_RS16710	COG1744	ABC transporter substrate-binding protein PnrA-like
HT135_RS16715	COG3845	ABC transporter
HT135_RS16720	COG4603	Belongs to the binding-protein-dependent transport system permease family
HT135_RS16725	COG1079	Belongs to the binding-protein-dependent transport system permease family
HT135_RS16730	COG3493	citrate carrier protein
HT135_RS16740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT135_RS16740	COG2111	Na H antiporter
HT135_RS16745	COG2111	Na H antiporter
HT135_RS16750	COG1006	Multisubunit Na H antiporter MnhC subunit
HT135_RS16755	COG0651	ATP synthesis coupled electron transport
HT135_RS16760	COG1863	multisubunit Na H antiporter MnhE subunit
HT135_RS16765	COG2212	antiporter activity
HT135_RS16770	COG1320	monovalent cation:proton antiporter activity
HT135_RS16775	COG2050	protein possibly involved in aromatic compounds catabolism
HT135_RS16780	COG2197	response regulator
HT135_RS16795	COG0142	geranyltranstransferase activity
HT135_RS16810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HT135_RS16815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HT135_RS16820	COG1335	isochorismatase
HT135_RS16825	COG5506	Protein of unknown function (DUF1694)
HT135_RS16840	COG0628	permease
HT135_RS16850	COG1418	mRNA catabolic process
HT135_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS16865	COG1511	domain protein
HT135_RS16870	COG0433	COG0433 Predicted ATPase
HT135_RS16870	COG1674	ftsk spoiiie
HT135_RS16875	COG4499	WXG100 protein secretion system (Wss), protein YukC
HT135_RS16880	COG5417	Belongs to the EsaB family
HT135_RS16885	COG4842	Belongs to the WXG100 family
HT135_RS16890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HT135_RS16890	COG2508	Transcriptional regulator
HT135_RS16895	COG0686	Belongs to the AlaDH PNT family
HT135_RS16900	COG5634	Uncharacterized conserved protein (DUF2278)
HT135_RS16905	COG3251	PFAM MbtH domain protein
HT135_RS16910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS16915	COG1535	isochorismatase
HT135_RS16915	COG3433	isochorismatase activity
HT135_RS16920	COG1021	2,3-dihydroxybenzoate-AMP ligase
HT135_RS16925	COG1169	isochorismate synthase
HT135_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS16935	COG2819	hydrolase of the alpha beta superfamily
HT135_RS16940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HT135_RS16945	COG1268	BioY protein
HT135_RS16950	COG2056	Na+-H+ antiporter family
HT135_RS16955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HT135_RS16960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HT135_RS16965	COG3584	3D domain protein
HT135_RS16980	COG1252	NADH dehydrogenase
HT135_RS16985	COG0492	ferredoxin-NADP+ reductase activity
HT135_RS16995	COG0516	GMP reductase activity
HT135_RS17000	COG0316	Belongs to the HesB IscA family
HT135_RS17005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HT135_RS17010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_RS17015	COG4844	belongs to the
HT135_RS17020	COG1252	NADH dehydrogenase
HT135_RS17025	COG4837	Protein of unknown function (DUF1462)
HT135_RS17030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HT135_RS17035	COG4946	Tricorn protease homolog
HT135_RS17035	COG0823	Involved in the tonB-independent uptake of proteins
HT135_RS17035	COG1506	peptidase
HT135_RS17040	COG0083	homoserine kinase activity
HT135_RS17045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HT135_RS17050	COG0460	homoserine dehydrogenase
HT135_RS17055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_RS17060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HT135_RS17065	COG0647	UMP catabolic process
HT135_RS17070	COG2445	Protein of unknown function DUF86
HT135_RS17075	COG4470	Protein conserved in bacteria
HT135_RS17090	COG0739	heme binding
HT135_RS17100	COG3377	Domain of unknown function (DUF1805)
HT135_RS17105	COG0737	Belongs to the 5'-nucleotidase family
HT135_RS17110	COG0730	response to heat
HT135_RS17115	COG1801	Protein of unknown function DUF72
HT135_RS17125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HT135_RS17130	COG2508	Transcriptional regulator
HT135_RS17135	COG2233	PERMEase
HT135_RS17140	COG2233	PERMEase
HT135_RS17145	COG3648	Uricase
HT135_RS17145	COG3195	allantoin biosynthetic process
HT135_RS17150	COG2351	hydroxyisourate hydrolase activity
HT135_RS17160	COG2080	2 iron, 2 sulfur cluster binding
HT135_RS17165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HT135_RS17170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HT135_RS17175	COG2068	MobA-Related Protein
HT135_RS17180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HT135_RS17185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HT135_RS17190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_RS17195	COG2356	endonuclease I
HT135_RS17200	COG3842	ATPase activity
HT135_RS17205	COG2188	Transcriptional regulator
HT135_RS17210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_RS17215	COG0395	ABC-type sugar transport system, permease component
HT135_RS17220	COG1175	transmembrane transport
HT135_RS17225	COG1653	transport
HT135_RS17230	COG2222	sugar isomerase
HT135_RS17235	COG0322	excinuclease ABC activity
HT135_RS17240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_RS17260	COG0719	Fe-S assembly protein
HT135_RS17265	COG0822	iron-sulfur transferase activity
HT135_RS17270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HT135_RS17275	COG0719	Fe-S assembly protein
HT135_RS17280	COG0396	ATPase activity
HT135_RS17290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT135_RS17295	COG1464	Belongs to the NlpA lipoprotein family
HT135_RS17300	COG2011	ABC-type metal ion transport system permease component
HT135_RS17305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HT135_RS17315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_RS17320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HT135_RS17330	COG0509	glycine decarboxylation via glycine cleavage system
HT135_RS17335	COG1393	Belongs to the ArsC family
HT135_RS17340	COG1960	acyl-CoA dehydrogenase activity
HT135_RS17345	COG0183	Belongs to the thiolase family
HT135_RS17350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HT135_RS17350	COG1024	Enoyl-CoA hydratase
HT135_RS17360	COG0506	proline dehydrogenase activity
HT135_RS17370	COG5577	PFAM Coat F domain
HT135_RS17375	COG1846	Transcriptional regulator
HT135_RS17380	COG0477	Major facilitator Superfamily
HT135_RS17385	COG1942	4-Oxalocrotonate Tautomerase
HT135_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS17395	COG0583	DNA-binding transcription factor activity
HT135_RS17405	COG1120	ATPase activity
HT135_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS17425	COG0783	Belongs to the Dps family
HT135_RS17430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_RS17435	COG0745	RESPONSE REGULATOR receiver
HT135_RS17440	COG2770	Histidine kinase
HT135_RS17440	COG2205	protein histidine kinase activity
HT135_RS17450	COG1309	transcriptional regulator
HT135_RS17455	COG0114	fumarate hydratase activity
HT135_RS17465	COG0697	spore germination
HT135_RS17470	COG0814	amino acid
HT135_RS17480	COG2197	response regulator
HT135_RS17485	COG4585	Histidine kinase
HT135_RS17490	COG4758	membrane
HT135_RS17495	COG3595	metallopeptidase activity
HT135_RS17500	COG1842	Phage shock protein A
HT135_RS17505	COG4758	membrane
HT135_RS17510	COG2814	Major facilitator Superfamily
HT135_RS17515	COG2096	Adenosyltransferase
HT135_RS17520	COG1120	ATPase activity
HT135_RS17525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS17530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS17540	COG3386	PFAM SMP-30 Gluconolaconase
HT135_RS17545	COG2205	protein histidine kinase activity
HT135_RS17550	COG0745	RESPONSE REGULATOR receiver
HT135_RS17560	COG1191	sigma factor activity
HT135_RS17570	COG2140	Oxalate decarboxylase
HT135_RS17580	COG0577	efflux transmembrane transporter activity
HT135_RS17585	COG1136	(ABC) transporter
HT135_RS17590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT135_RS17595	COG1120	ATPase activity
HT135_RS17600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS17605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_RS17610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS17615	COG0531	amino acid
HT135_RS17625	COG1988	membrane-bound metal-dependent
HT135_RS17630	COG1368	sulfuric ester hydrolase activity
HT135_RS17635	COG1910	domain protein
HT135_RS17640	COG0725	ABC transporter, periplasmic molybdate-binding protein
HT135_RS17645	COG4149	molybdate abc transporter
HT135_RS17650	COG0656	L-ascorbic acid biosynthetic process
HT135_RS17660	COG0025	NhaP-type Na H and K H
HT135_RS17665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_RS17670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_RS17675	COG3973	AAA domain
HT135_RS17685	COG2860	membrane
HT135_RS17690	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HT135_RS17695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HT135_RS17700	COG2217	Heavy metal translocating P-type atpase
HT135_RS17705	COG2217	Heavy metal translocating P-type atpase
HT135_RS17710	COG2608	mercury ion transmembrane transporter activity
HT135_RS17715	COG1937	Protein conserved in bacteria
HT135_RS17720	COG0673	inositol 2-dehydrogenase activity
HT135_RS17725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HT135_RS17730	COG1289	transmembrane transporter activity
HT135_RS17735	COG1802	Transcriptional regulator
HT135_RS17740	COG0697	spore germination
HT135_RS17750	COG2076	Multidrug Resistance protein
HT135_RS17755	COG1309	transcriptional regulator
HT135_RS17760	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS17770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HT135_RS17775	COG0557	exoribonuclease II activity
HT135_RS17780	COG1647	Serine aminopeptidase, S33
HT135_RS17785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT135_RS17790	COG0596	Alpha beta hydrolase
HT135_RS17795	COG1476	TRANSCRIPTIONal
HT135_RS17800	COG1396	sequence-specific DNA binding
HT135_RS17805	COG1396	sequence-specific DNA binding
HT135_RS17810	COG1733	regulation of RNA biosynthetic process
HT135_RS17815	COG0840	transmembrane signaling receptor activity
HT135_RS17820	COG1174	glycine betaine transport
HT135_RS17825	COG1732	Glycine betaine
HT135_RS17830	COG1174	glycine betaine transport
HT135_RS17835	COG1125	glycine betaine transport
HT135_RS17835	COG0517	IMP dehydrogenase activity
HT135_RS17840	COG1510	regulation of RNA biosynthetic process
HT135_RS17860	COG5658	integral membrane protein
HT135_RS17865	COG0640	Transcriptional regulator
HT135_RS17870	COG1174	glycine betaine transport
HT135_RS17875	COG1732	Glycine betaine
HT135_RS17880	COG1174	glycine betaine transport
HT135_RS17885	COG1125	glycine betaine transport
HT135_RS17885	COG0517	IMP dehydrogenase activity
HT135_RS17890	COG1510	regulation of RNA biosynthetic process
HT135_RS17900	COG3064	Membrane
HT135_RS17905	COG4640	response to antibiotic
HT135_RS17910	COG0456	acetyltransferase
HT135_RS17925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_RS17945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_RS17950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_RS17960	COG2234	aminopeptidase activity
HT135_RS17970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HT135_RS17975	COG0149	triose-phosphate isomerase activity
HT135_RS17980	COG0126	phosphoglycerate kinase activity
HT135_RS17985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT135_RS17990	COG2390	Transcriptional regulator
HT135_RS17995	COG2814	Major facilitator Superfamily
HT135_RS18000	COG1609	Transcriptional regulator
HT135_RS18005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS18010	COG0583	DNA-binding transcription factor activity
HT135_RS18015	COG0697	spore germination
HT135_RS18020	COG1113	amino acid transport
HT135_RS18025	COG3858	chitin binding
HT135_RS18030	COG1556	Lactate utilization protein
HT135_RS18035	COG1139	Iron-sulfur cluster binding protein
HT135_RS18040	COG0247	lactate metabolic process
HT135_RS18045	COG2197	response regulator
HT135_RS18050	COG4585	Histidine kinase
HT135_RS18055	COG0842	Transport permease protein
HT135_RS18060	COG1131	(ABC) transporter
HT135_RS18065	COG0596	Alpha beta hydrolase
HT135_RS18070	COG2208	phosphoserine phosphatase activity
HT135_RS18075	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HT135_RS18080	COG1874	Beta-galactosidase
HT135_RS18085	COG3833	ABC-type maltose transport systems, permease component
HT135_RS18090	COG1175	transmembrane transport
HT135_RS18095	COG2182	Extracellular solute-binding protein
HT135_RS18100	COG1609	Transcriptional regulator
HT135_RS18105	COG2186	Transcriptional regulator
HT135_RS18110	COG1620	l-lactate permease
HT135_RS18115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HT135_RS18125	COG5039	Polysaccharide pyruvyl transferase
HT135_RS18130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_RS18135	COG0110	maltose O-acetyltransferase activity
HT135_RS18140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HT135_RS18145	COG2244	polysaccharide biosynthetic process
HT135_RS18150	COG1216	Glycosyl transferase, family 2
HT135_RS18155	COG5039	Polysaccharide pyruvyl transferase
HT135_RS18160	COG1216	Glycosyl transferase, family 2
HT135_RS18170	COG0438	transferase activity, transferring glycosyl groups
HT135_RS18175	COG1215	transferase activity, transferring glycosyl groups
HT135_RS18180	COG0438	transferase activity, transferring glycosyl groups
HT135_RS18185	COG1086	Polysaccharide biosynthesis protein
HT135_RS18190	COG0489	protein tyrosine kinase activity
HT135_RS18195	COG3944	biosynthesis protein
HT135_RS18200	COG1396	sequence-specific DNA binding
HT135_RS18205	COG2272	Belongs to the type-B carboxylesterase lipase family
HT135_RS18215	COG3479	Phenolic acid decarboxylase
HT135_RS18225	COG1794	racemase activity, acting on amino acids and derivatives
HT135_RS18230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_RS18240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_RS18245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT135_RS18250	COG0640	Transcriptional regulator
HT135_RS18255	COG1621	beta-fructofuranosidase activity
HT135_RS18260	COG1621	beta-fructofuranosidase activity
HT135_RS18265	COG0531	amino acid
HT135_RS18270	COG1309	transcriptional regulator
HT135_RS18275	COG2076	Multidrug Resistance protein
HT135_RS18280	COG2076	Multidrug Resistance protein
HT135_RS18295	COG0277	FAD linked oxidase domain protein
HT135_RS18300	COG3621	Patatin-like phospholipase
HT135_RS18315	COG1611	Belongs to the LOG family
HT135_RS18320	COG1694	Mazg nucleotide pyrophosphohydrolase
HT135_RS18325	COG0659	secondary active sulfate transmembrane transporter activity
HT135_RS18330	COG0288	reversible hydration of carbon dioxide
HT135_RS18335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT135_RS18340	COG0577	efflux transmembrane transporter activity
HT135_RS18345	COG1136	(ABC) transporter
HT135_RS18350	COG5002	protein histidine kinase activity
HT135_RS18355	COG0745	RESPONSE REGULATOR receiver
HT135_RS18365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HT135_RS18370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS18375	COG1481	regulation of sporulation
HT135_RS18380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HT135_RS18385	COG1660	Displays ATPase and GTPase activities
HT135_RS18390	COG1051	belongs to the nudix hydrolase family
HT135_RS18395	COG0492	ferredoxin-NADP+ reductase activity
HT135_RS18400	COG3883	PFAM NLP P60 protein
HT135_RS18400	COG0791	NLP P60 protein
HT135_RS18405	COG0457	Tetratricopeptide repeat
HT135_RS18410	COG1132	(ABC) transporter
HT135_RS18430	COG0140	phosphoribosyl-ATP diphosphatase activity
HT135_RS18430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HT135_RS18435	COG0107	imidazoleglycerol-phosphate synthase activity
HT135_RS18440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HT135_RS18445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HT135_RS18450	COG0131	Imidazoleglycerol-phosphate dehydratase
HT135_RS18455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HT135_RS18460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HT135_RS18465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HT135_RS18470	COG4990	cell redox homeostasis
HT135_RS18475	COG5297	Belongs to the glycosyl hydrolase family 6
HT135_RS18480	COG0110	maltose O-acetyltransferase activity
HT135_RS18485	COG0546	phosphoglycolate phosphatase activity
HT135_RS18490	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HT135_RS18495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HT135_RS18500	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HT135_RS18505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HT135_RS18510	COG0363	glucosamine-6-phosphate deaminase activity
HT135_RS18515	COG2188	Transcriptional regulator
HT135_RS18520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HT135_RS18530	COG1846	Transcriptional regulator
HT135_RS18535	COG2814	Major facilitator Superfamily
HT135_RS18540	COG1950	PFAM Membrane protein of
HT135_RS18545	COG1983	PspC domain protein
HT135_RS18550	COG3595	metallopeptidase activity
HT135_RS18565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HT135_RS18575	COG4897	Protein conserved in bacteria
HT135_RS18580	COG0574	Belongs to the PEP-utilizing enzyme family
HT135_RS18580	COG3848	Pyruvate phosphate dikinase
HT135_RS18585	COG1309	transcriptional regulator
HT135_RS18590	COG2814	Major facilitator Superfamily
HT135_RS18595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_RS18605	COG3409	Peptidoglycan-binding domain 1 protein
HT135_RS18605	COG0793	Belongs to the peptidase S41A family
HT135_RS18610	COG2177	Part of the ABC transporter FtsEX involved in
HT135_RS18615	COG2884	Cell division ATP-binding protein ftsE
HT135_RS18620	COG2010	Cytochrome c
HT135_RS18625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS18635	COG0653	protein targeting
HT135_RS18640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HT135_RS18655	COG1516	flagellar protein fliS
HT135_RS18660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HT135_RS18665	COG1334	flagellar protein FlaG
HT135_RS18670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HT135_RS18675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HT135_RS18680	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HT135_RS18690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HT135_RS18695	COG4786	Flagellar basal body rod
HT135_RS18695	COG1256	bacterial-type flagellum assembly
HT135_RS18700	COG3418	PFAM FlgN family protein
HT135_RS18705	COG2747	anti-sigma28 factor FlgM
HT135_RS18715	COG1040	competence protein
HT135_RS18725	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HT135_RS18730	COG1307	EDD domain protein, DegV family
HT135_RS18735	COG2197	response regulator
HT135_RS18740	COG4585	Histidine kinase
HT135_RS18745	COG1739	Uncharacterized protein family UPF0029
HT135_RS18750	COG1316	TRANSCRIPTIONal
HT135_RS18755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HT135_RS18760	COG0438	transferase activity, transferring glycosyl groups
HT135_RS18765	COG1215	transferase activity, transferring glycosyl groups
HT135_RS18770	COG3206	protein involved in exopolysaccharide biosynthesis
HT135_RS18775	COG3307	-O-antigen
HT135_RS18780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HT135_RS18785	COG0438	transferase activity, transferring glycosyl groups
HT135_RS18785	COG0297	glycogen (starch) synthase activity
HT135_RS18790	COG2244	polysaccharide biosynthetic process
HT135_RS18800	COG2247	cell wall binding repeat
HT135_RS18800	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_RS18805	COG2385	sporulation resulting in formation of a cellular spore
HT135_RS18805	COG2247	cell wall binding repeat
HT135_RS18815	COG1316	TRANSCRIPTIONal
HT135_RS18820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HT135_RS18835	COG0438	transferase activity, transferring glycosyl groups
HT135_RS18840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HT135_RS18845	COG1134	teichoic acid transport
HT135_RS18850	COG1682	transport, permease protein
HT135_RS18870	COG0463	Glycosyl transferase, family 2
HT135_RS18915	COG4193	domain, Protein
HT135_RS18920	COG1482	cell wall glycoprotein biosynthetic process
HT135_RS18925	COG0697	spore germination
HT135_RS18930	COG0814	amino acid
HT135_RS18940	COG2814	Major facilitator Superfamily
HT135_RS18945	COG1316	TRANSCRIPTIONal
HT135_RS18950	COG0561	phosphatase activity
HT135_RS18955	COG0791	NLP P60 protein
HT135_RS18965	COG2843	Capsule synthesis protein
HT135_RS18975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HT135_RS18980	COG1609	Transcriptional regulator
HT135_RS18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_RS18990	COG1869	D-ribose catabolic process
HT135_RS18995	COG1129	ABC transporter
HT135_RS19000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT135_RS19005	COG1879	ABC-type sugar transport system periplasmic component
HT135_RS19010	COG3103	Sh3 type 3 domain protein
HT135_RS19020	COG2249	NAD(P)H dehydrogenase (quinone) activity
HT135_RS19025	COG3527	Alpha-acetolactate decarboxylase
HT135_RS19030	COG0028	Belongs to the TPP enzyme family
HT135_RS19035	COG0583	DNA-binding transcription factor activity
HT135_RS19040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT135_RS19055	COG5337	Spore coat protein CotH
HT135_RS19065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HT135_RS19070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS19085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT135_RS19095	COG0405	Gamma-glutamyltransferase
HT135_RS19100	COG1522	sequence-specific DNA binding
HT135_RS19105	COG2059	Chromate
HT135_RS19110	COG2059	Chromate
HT135_RS19120	COG0655	NAD(P)H dehydrogenase (quinone) activity
HT135_RS19125	COG0583	DNA-binding transcription factor activity
HT135_RS19160	COG5444	nuclease activity
HT135_RS19185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HT135_RS19190	COG4464	protein tyrosine phosphatase activity
HT135_RS19195	COG0489	protein tyrosine kinase activity
HT135_RS19200	COG3944	biosynthesis protein
HT135_RS19210	COG4715	Zinc finger, swim domain protein
HT135_RS19215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HT135_RS19220	COG0561	phosphatase activity
HT135_RS19225	COG1349	DNA-binding transcription factor activity
HT135_RS19230	COG0629	single-stranded DNA binding
HT135_RS19245	COG2602	Beta-lactamase
HT135_RS19250	COG1970	mechanosensitive ion channel activity
HT135_RS19255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HT135_RS19260	COG0457	Tetratricopeptide repeat
HT135_RS19265	COG4786	Flagellar basal body rod
HT135_RS19270	COG4786	Flagellar basal body rod
HT135_RS19275	COG1077	Cell shape determining protein MreB Mrl
HT135_RS19280	COG1609	Transcriptional regulator
HT135_RS19290	COG1846	Transcriptional regulator
HT135_RS19295	COG2814	Major facilitator Superfamily
HT135_RS19300	COG3420	alginic acid biosynthetic process
HT135_RS19305	COG1953	Uracil, thiamine, allantoin
HT135_RS19310	COG0477	Major facilitator Superfamily
HT135_RS19315	COG1335	isochorismatase
HT135_RS19325	COG0004	ammonium transporteR
HT135_RS19330	COG0347	Belongs to the P(II) protein family
HT135_RS19335	COG0671	phosphoesterase, PA-phosphatase related
HT135_RS19345	COG0739	heme binding
HT135_RS19350	COG1247	-acetyltransferase
HT135_RS19365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_RS19375	COG2910	NAD(P)H-binding
HT135_RS19380	COG1959	2 iron, 2 sulfur cluster binding
HT135_RS19385	COG0804	urea catabolic process
HT135_RS19390	COG0832	Belongs to the urease beta subunit family
HT135_RS19395	COG0831	urea catabolic process
HT135_RS19425	COG3237	CsbD-like
HT135_RS19430	COG1994	Peptidase M50
HT135_RS19435	COG0457	Tetratricopeptide repeat
HT135_RS19440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HT135_RS19445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HT135_RS19455	COG2304	oxidoreductase activity
HT135_RS19460	COG2304	oxidoreductase activity
HT135_RS19465	COG2385	sporulation resulting in formation of a cellular spore
HT135_RS19470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HT135_RS19480	COG4836	Membrane
HT135_RS19490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HT135_RS19495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HT135_RS19500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HT135_RS19510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HT135_RS19515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HT135_RS19525	COG0356	it plays a direct role in the translocation of protons across the membrane
HT135_RS19535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HT135_RS19540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HT135_RS19545	COG4475	Protein of unknown function (DUF436)
HT135_RS19550	COG0698	ribose 5-phosphate isomerase
HT135_RS19555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_RS19560	COG1971	Probably functions as a manganese efflux pump
HT135_RS19565	COG0009	L-threonylcarbamoyladenylate synthase
HT135_RS19570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HT135_RS19590	COG2890	protein-(glutamine-N5) methyltransferase activity
HT135_RS19595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HT135_RS19600	COG0346	lactoylglutathione lyase activity
HT135_RS19605	COG0789	Transcriptional regulator
HT135_RS19610	COG0679	Auxin Efflux Carrier
HT135_RS19615	COG0281	malic enzyme
HT135_RS19620	COG1435	thymidine kinase activity
HT135_RS19630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HT135_RS19640	COG1494	fructose-1,6-bisphosphatase
HT135_RS19645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HT135_RS19650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HT135_RS19655	COG0191	fructose-bisphosphate aldolase activity
HT135_RS19660	COG2204	response regulator
HT135_RS19665	COG4821	SIS domain
HT135_RS19670	COG0504	CTP synthase activity
HT135_RS19675	COG3343	RNA polymerase activity
HT135_RS19680	COG1960	acyl-CoA dehydrogenase activity
HT135_RS19685	COG2181	nitrate reductase activity
HT135_RS19685	COG0247	lactate metabolic process
HT135_RS19690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_RS19695	COG4294	response to UV
HT135_RS19705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_RS19710	COG1132	(ABC) transporter
HT135_RS19715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_RS19725	COG2181	nitrate reductase activity
HT135_RS19730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HT135_RS19735	COG1140	nitrate reductase beta subunit
HT135_RS19740	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HT135_RS19745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT135_RS19755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT135_RS19760	COG2223	nitrite transmembrane transporter activity
HT135_RS19765	COG0018	arginyl-trna synthetase
HT135_RS19770	COG4506	Protein conserved in bacteria
HT135_RS19780	COG0535	radical SAM domain protein
HT135_RS19790	COG1131	(ABC) transporter
HT135_RS19800	COG0612	Peptidase, M16
HT135_RS19820	COG3391	amine dehydrogenase activity
HT135_RS19825	COG0457	Tetratricopeptide repeat
HT135_RS19835	COG0010	Belongs to the arginase family
HT135_RS19840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HT135_RS19845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_RS19860	COG1994	Peptidase M50
HT135_RS19865	COG1942	4-Oxalocrotonate Tautomerase
HT135_RS19870	COG1846	Transcriptional regulator
HT135_RS19875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HT135_RS19880	COG0477	Major facilitator Superfamily
HT135_RS19885	COG1959	2 iron, 2 sulfur cluster binding
HT135_RS19890	COG3465	dGTPase activity
HT135_RS19895	COG1078	dGTPase activity
HT135_RS19900	COG4844	belongs to the
HT135_RS19910	COG0697	spore germination
HT135_RS19915	COG0095	Lipoate-protein ligase
HT135_RS19920	COG0583	DNA-binding transcription factor activity
HT135_RS19925	COG0280	phosphate acetyltransferase
HT135_RS19930	COG3253	May function as heme-dependent peroxidase
HT135_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS19940	COG0436	Aminotransferase
HT135_RS19945	COG2814	Major facilitator Superfamily
HT135_RS19950	COG0151	Belongs to the GarS family
HT135_RS19955	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS19960	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS19965	COG0077	Prephenate dehydratase
HT135_RS19970	COG2814	Major facilitator Superfamily
HT135_RS19980	COG0833	amino acid
HT135_RS19985	COG4187	Peptidase family M20/M25/M40
HT135_RS19990	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS19995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_RS20005	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HT135_RS20010	COG1091	dTDP-4-dehydrorhamnose reductase activity
HT135_RS20015	COG1088	dTDP-glucose 4,6-dehydratase activity
HT135_RS20020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HT135_RS20025	COG3980	spore coat polysaccharide biosynthesis protein
HT135_RS20030	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HT135_RS20035	COG2089	acid synthase
HT135_RS20040	COG0456	acetyltransferase
HT135_RS20045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_RS20050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HT135_RS20055	COG0463	Glycosyl transferase, family 2
HT135_RS20065	COG2363	Small membrane protein
HT135_RS20070	COG2233	PERMEase
HT135_RS20080	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS20085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HT135_RS20090	COG1216	Glycosyl transferase, family 2
HT135_RS20105	COG1695	Transcriptional regulator
HT135_RS20110	COG0351	phosphomethylpyrimidine kinase
HT135_RS20120	COG1621	beta-fructofuranosidase activity
HT135_RS20125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS20125	COG1263	PTS System
HT135_RS20130	COG2116	formate transmembrane transporter activity
HT135_RS20135	COG3711	transcriptional antiterminator
HT135_RS20145	COG1404	Belongs to the peptidase S8 family
HT135_RS20150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS20155	COG0778	Nitroreductase
HT135_RS20160	COG0772	Belongs to the SEDS family
HT135_RS20180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HT135_RS20185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HT135_RS20190	COG2261	transglycosylase associated protein
HT135_RS20195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HT135_RS20200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HT135_RS20205	COG2246	polysaccharide biosynthetic process
HT135_RS20210	COG1309	transcriptional regulator
HT135_RS20220	COG3162	membrane
HT135_RS20225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_RS20230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HT135_RS20235	COG2837	iron assimilation
HT135_RS20240	COG2822	iron ion transport
HT135_RS20245	COG0672	)-iron permease
HT135_RS20250	COG0352	thiamine-phosphate diphosphorylase activity
HT135_RS20255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HT135_RS20260	COG0583	DNA-binding transcription factor activity
HT135_RS20265	COG1380	Effector of murein hydrolase LrgA
HT135_RS20270	COG1346	cytolysis
HT135_RS20275	COG2814	Major facilitator Superfamily
HT135_RS20280	COG4895	conserved protein (DUF2196)
HT135_RS20285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HT135_RS20290	COG0346	lactoylglutathione lyase activity
HT135_RS20300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_RS20305	COG1404	Belongs to the peptidase S8 family
HT135_RS20310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS20310	COG1263	PTS System
HT135_RS20315	COG3711	transcriptional antiterminator
HT135_RS20320	COG1442	glycosyl transferase family 8
HT135_RS20325	COG5522	Integral membrane protein (intg_mem_TP0381)
HT135_RS20330	COG1846	Transcriptional regulator
HT135_RS20335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HT135_RS20340	COG2234	aminopeptidase activity
HT135_RS20345	COG2357	RelA SpoT domain protein
HT135_RS20350	COG1575	Belongs to the MenA family. Type 1 subfamily
HT135_RS20360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_RS20365	COG1696	Membrane protein involved in D-alanine export
HT135_RS20370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_RS20375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HT135_RS20380	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HT135_RS20385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_RS20390	COG1486	melibiose metabolic process
HT135_RS20395	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT135_RS20400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_RS20405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_RS20410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_RS20410	COG3711	transcriptional antiterminator
HT135_RS20420	COG2094	Belongs to the DNA glycosylase MPG family
HT135_RS20425	COG0753	catalase activity
HT135_RS20430	COG2814	Major facilitator Superfamily
HT135_RS20435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_RS20440	COG1131	(ABC) transporter
HT135_RS20460	COG1595	DNA-templated transcription, initiation
HT135_RS20465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT135_RS20470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HT135_RS20475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HT135_RS20480	COG4988	ABC transporter
HT135_RS20485	COG1294	oxidase, subunit
HT135_RS20490	COG1271	oxidase subunit
HT135_RS20495	COG3493	citrate carrier protein
HT135_RS20500	COG0501	Belongs to the peptidase M48B family
HT135_RS20510	COG0726	polysaccharide deacetylase
HT135_RS20520	COG3842	ATPase activity
HT135_RS20525	COG2508	Transcriptional regulator
HT135_RS20530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_RS20540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HT135_RS20550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT135_RS20565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_RS20570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_RS20575	COG3829	transcription factor binding
HT135_RS20575	COG3290	protein histidine kinase activity
HT135_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS20585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HT135_RS20590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HT135_RS20595	COG2610	gluconate transmembrane transporter activity
HT135_RS20600	COG0500	methyltransferase
HT135_RS20605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_RS20620	COG0753	catalase activity
HT135_RS20620	COG0693	protein deglycase activity
HT135_RS20625	COG2851	Citrate transporter
HT135_RS20635	COG2723	6-phospho-beta-galactosidase activity
HT135_RS20640	COG1263	PTS System
HT135_RS20640	COG2190	(PTS) system
HT135_RS20640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS20645	COG3711	transcriptional antiterminator
HT135_RS20655	COG2270	Major facilitator Superfamily
HT135_RS20660	COG0513	Belongs to the DEAD box helicase family
HT135_RS20665	COG3401	FG-GAP repeat protein
HT135_RS20665	COG2755	lipolytic protein G-D-S-L family
HT135_RS20720	COG0697	spore germination
HT135_RS20725	COG0589	response to stress
HT135_RS20730	COG2723	6-phospho-beta-galactosidase activity
HT135_RS20735	COG2190	(PTS) system
HT135_RS20735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_RS20735	COG1263	PTS System
HT135_RS20755	COG5444	nuclease activity
HT135_RS20790	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_RS20805	COG2986	histidine ammonia-lyase
HT135_RS20810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HT135_RS20815	COG1228	amidohydrolase
HT135_RS20820	COG0010	Belongs to the arginase family
HT135_RS20825	COG0833	amino acid
HT135_RS20830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HT135_RS20835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_RS20840	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HT135_RS20845	COG2390	Transcriptional regulator
HT135_RS20855	COG3192	ethanolamine utilization protein
HT135_RS20860	COG2079	MmgE PrpD family protein
HT135_RS20865	COG1473	amidohydrolase
HT135_RS20870	COG1126	abc transporter atp-binding protein
HT135_RS20875	COG0765	amino acid transport
HT135_RS20880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_RS20885	COG0456	acetyltransferase
HT135_RS20890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_RS20900	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HT135_RS20905	COG0561	phosphatase activity
HT135_RS20935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_RS20940	COG5294	Protein conserved in bacteria
HT135_RS20945	COG0577	efflux transmembrane transporter activity
HT135_RS20950	COG1136	(ABC) transporter
HT135_RS20955	COG2205	protein histidine kinase activity
HT135_RS20960	COG0745	RESPONSE REGULATOR receiver
HT135_RS20965	COG0191	fructose-bisphosphate aldolase activity
HT135_RS20975	COG1082	Xylose isomerase domain protein TIM barrel
HT135_RS20980	COG0673	inositol 2-dehydrogenase activity
HT135_RS20985	COG2814	Major facilitator Superfamily
HT135_RS20990	COG1082	Xylose isomerase domain protein TIM barrel
HT135_RS20995	COG3962	Belongs to the TPP enzyme family
HT135_RS21000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_RS21010	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS21015	COG1349	DNA-binding transcription factor activity
HT135_RS21020	COG0667	Aldo Keto reductase
HT135_RS21045	COG2814	Major facilitator Superfamily
HT135_RS21050	COG0326	Molecular chaperone. Has ATPase activity
HT135_RS21060	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS21065	COG1309	transcriptional regulator
HT135_RS21070	COG1012	belongs to the aldehyde dehydrogenase family
HT135_RS21075	COG1714	RDD family
HT135_RS21080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT135_RS21090	COG1714	RDD family
HT135_RS21095	COG2311	Membrane
HT135_RS21100	COG1917	Cupin 2, conserved barrel domain protein
HT135_RS21105	COG1309	transcriptional regulator
HT135_RS21110	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_RS21115	COG1846	Transcriptional regulator
HT135_RS21120	COG1380	Effector of murein hydrolase LrgA
HT135_RS21125	COG1346	cytolysis
HT135_RS21150	COG5039	Polysaccharide pyruvyl transferase
HT135_RS21155	COG1929	Belongs to the glycerate kinase type-1 family
HT135_RS21160	COG1802	Transcriptional regulator
HT135_RS21165	COG1070	Carbohydrate kinase
HT135_RS21170	COG2610	gluconate transmembrane transporter activity
HT135_RS21175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HT135_RS21180	COG0450	alkyl hydroperoxide reductase
HT135_RS21185	COG3634	alkyl hydroperoxide reductase activity
HT135_RS21190	COG2723	6-phospho-beta-galactosidase activity
HT135_RS21200	COG2188	Transcriptional regulator
HT135_RS21210	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HT135_RS21245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HT135_RS21260	COG1063	alcohol dehydrogenase
HT135_RS21280	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HT135_RS21285	COG0456	acetyltransferase
HT135_RS21290	COG0457	Tetratricopeptide repeat
HT135_RS21300	COG0010	Belongs to the arginase family
HT135_RS21305	COG0833	amino acid
HT135_RS21310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HT135_RS21315	COG3829	transcription factor binding
HT135_RS21320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_RS21325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HT135_RS21330	COG4853	Protein conserved in bacteria
HT135_RS21335	COG4863	YycH protein
HT135_RS21340	COG5002	protein histidine kinase activity
HT135_RS21345	COG0745	RESPONSE REGULATOR receiver
HT135_RS21375	COG0346	lactoylglutathione lyase activity
HT135_RS21380	COG0305	Participates in initiation and elongation during chromosome replication
HT135_RS21395	COG3093	addiction module antidote protein HigA
HT135_RS21400	COG2807	transmembrane transport
HT135_RS21405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HT135_RS21410	COG0359	binds to the 23S rRNA
HT135_RS21415	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HT135_RS21420	COG4241	membrane
HT135_RS21430	COG5577	PFAM Coat F domain
HT135_RS21435	COG1733	regulation of RNA biosynthetic process
HT135_RS21440	COG1227	inorganic diphosphatase activity
HT135_RS21450	COG2271	Major facilitator Superfamily
HT135_RS21465	COG4319	ketosteroid isomerase
HT135_RS21475	COG2814	Major facilitator Superfamily
HT135_RS21480	COG0583	DNA-binding transcription factor activity
HT135_RS21485	COG2153	protein acetylation
HT135_RS21495	COG0583	DNA-binding transcription factor activity
HT135_RS21510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_RS21520	COG0640	Transcriptional regulator
HT135_RS21525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HT135_RS21550	COG0300	oxidoreductase activity
HT135_RS21560	COG1902	pentaerythritol trinitrate reductase activity
HT135_RS21570	COG1309	transcriptional regulator
HT135_RS21580	COG1063	alcohol dehydrogenase
HT135_RS21590	COG0789	Transcriptional regulator
HT135_RS21590	COG4978	Transcriptional regulator
HT135_RS21595	COG1811	Na channel or pump
HT135_RS21600	COG2207	Transcriptional regulator
HT135_RS21600	COG3708	Transcriptional regulator
HT135_RS21620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_RS21625	COG1331	Highly conserved protein containing a thioredoxin domain
HT135_RS21645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_RS21650	COG2856	Zn peptidase
HT135_RS21685	COG1331	Highly conserved protein containing a thioredoxin domain
HT135_RS21690	COG1266	CAAX protease self-immunity
HT135_RS21695	COG0477	Major facilitator Superfamily
HT135_RS21695	COG2814	Major facilitator Superfamily
HT135_RS21700	COG0110	maltose O-acetyltransferase activity
HT135_RS21705	COG0346	lactoylglutathione lyase activity
HT135_RS21710	COG1609	Transcriptional regulator
HT135_RS21715	COG0708	Exodeoxyribonuclease III
HT135_RS21725	COG0629	single-stranded DNA binding
HT135_RS21730	COG0360	Binds together with S18 to 16S ribosomal RNA
HT135_RS21735	COG0012	GTP binding
HT135_RS21740	COG0243	molybdopterin cofactor binding
HT135_RS21745	COG4481	Protein conserved in bacteria
HT135_RS21750	COG3949	Membrane
HT135_RS21760	COG1475	DNA binding
HT135_RS21765	COG1192	Involved in chromosome partitioning
HT135_RS21775	COG1475	DNA binding
HT135_RS21780	COG0357	Ribosomal RNA small subunit methyltransferase G
HT135_RS21785	COG0445	tRNA wobble uridine modification
HT135_RS21790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HT135_RS21795	COG1847	R3H domain protein
HT135_RS21800	COG0706	membrane insertase activity
HT135_RS21805	COG0594	ribonuclease P activity