locus-tag	class	description
H2R00_RS00005	COG4109	DRTGG domain
H2R00_RS00015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2R00_RS00035	COG0587	DNA-directed DNA polymerase activity
H2R00_RS00040	COG0281	malic enzyme
H2R00_RS00045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H2R00_RS00050	COG0825	malonyl-CoA metabolic process
H2R00_RS00055	COG0205	6-phosphofructokinase activity
H2R00_RS00065	COG3030	protein affecting phage T7 exclusion by the F plasmid
H2R00_RS00070	COG0628	permease
H2R00_RS00075	COG2707	UPF0756 membrane protein
H2R00_RS00080	COG0372	Belongs to the citrate synthase family
H2R00_RS00085	COG0538	isocitrate dehydrogenase activity
H2R00_RS00090	COG0039	L-malate dehydrogenase activity
H2R00_RS00095	COG0745	RESPONSE REGULATOR receiver
H2R00_RS00100	COG5002	protein histidine kinase activity
H2R00_RS00105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2R00_RS00105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2R00_RS00110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2R00_RS00115	COG1971	Probably functions as a manganese efflux pump
H2R00_RS00120	COG0237	dephospho-CoA kinase activity
H2R00_RS00125	COG3866	Pectate lyase
H2R00_RS00130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2R00_RS00135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H2R00_RS00145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2R00_RS00150	COG3611	Membrane attachment protein
H2R00_RS00155	COG1484	DNA-dependent DNA replication
H2R00_RS00160	COG0398	Pfam SNARE associated Golgi protein
H2R00_RS00170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2R00_RS00175	COG1011	Hydrolase
H2R00_RS00185	COG3275	phosphorelay sensor kinase activity
H2R00_RS00190	COG3279	Response regulator of the LytR AlgR family
H2R00_RS00195	COG3540	Alkaline phosphatase
H2R00_RS00205	COG1346	cytolysis
H2R00_RS00210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2R00_RS00215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2R00_RS00220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H2R00_RS00225	COG3326	Membrane
H2R00_RS00235	COG1363	Peptidase, m42
H2R00_RS00240	COG3507	Belongs to the glycosyl hydrolase 43 family
H2R00_RS00245	COG2160	L-arabinose isomerase activity
H2R00_RS00250	COG1069	ribulokinase activity
H2R00_RS00255	COG0235	Class ii aldolase
H2R00_RS00260	COG0371	Dehydrogenase
H2R00_RS00265	COG1653	transport
H2R00_RS00270	COG1175	transmembrane transport
H2R00_RS00275	COG0395	ABC-type sugar transport system, permease component
H2R00_RS00290	COG1966	Carbon starvation protein
H2R00_RS00300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2R00_RS00305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2R00_RS00310	COG0072	phenylalanine-tRNA ligase activity
H2R00_RS00310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2R00_RS00320	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2R00_RS00325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H2R00_RS00330	COG1286	toxin biosynthetic process
H2R00_RS00335	COG1796	DNA polymerase
H2R00_RS00335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2R00_RS00340	COG1193	negative regulation of DNA recombination
H2R00_RS00345	COG3766	membrane
H2R00_RS00350	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS00355	COG1309	transcriptional regulator
H2R00_RS00360	COG1024	Enoyl-CoA hydratase
H2R00_RS00365	COG2086	electron transfer activity
H2R00_RS00370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2R00_RS00375	COG3118	belongs to the thioredoxin family
H2R00_RS00380	COG0322	excinuclease ABC activity
H2R00_RS00385	COG0527	aspartate kinase activity
H2R00_RS00400	COG0577	efflux transmembrane transporter activity
H2R00_RS00400	COG1136	(ABC) transporter
H2R00_RS00410	COG1719	4-vinyl reductase, 4VR
H2R00_RS00415	COG2009	succinate dehydrogenase
H2R00_RS00420	COG1053	succinate dehydrogenase
H2R00_RS00425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2R00_RS00430	COG0824	Thioesterase
H2R00_RS00435	COG0300	oxidoreductase activity
H2R00_RS00440	COG2197	response regulator
H2R00_RS00445	COG1846	Transcriptional regulator
H2R00_RS00450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2R00_RS00455	COG5401	PFAM Sporulation and spore germination
H2R00_RS00460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2R00_RS00465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2R00_RS00470	COG0622	Phosphoesterase
H2R00_RS00495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2R00_RS00505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2R00_RS00510	COG0028	Belongs to the TPP enzyme family
H2R00_RS00515	COG0440	acetolactate synthase activity
H2R00_RS00520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2R00_RS00525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2R00_RS00530	COG0473	3-isopropylmalate dehydrogenase activity
H2R00_RS00535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2R00_RS00540	COG0066	3-isopropylmalate dehydratase activity
H2R00_RS00545	COG1477	protein flavinylation
H2R00_RS00545	COG0457	Tetratricopeptide repeat
H2R00_RS00550	COG0544	peptidyl-prolyl cis-trans isomerase activity
H2R00_RS00555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2R00_RS00560	COG1067	ATP-dependent peptidase activity
H2R00_RS00560	COG0470	DNA polymerase III
H2R00_RS00565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H2R00_RS00570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H2R00_RS00580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H2R00_RS00585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2R00_RS00590	COG0181	hydroxymethylbilane synthase activity
H2R00_RS00595	COG1587	Uroporphyrinogen-III synthase
H2R00_RS00600	COG0113	porphobilinogen synthase activity
H2R00_RS00605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2R00_RS00610	COG1388	LysM domain
H2R00_RS00615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2R00_RS00625	COG0525	valine-tRNA ligase activity
H2R00_RS00630	COG0285	dihydrofolate synthase activity
H2R00_RS00635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H2R00_RS00645	COG0424	maF-like protein
H2R00_RS00650	COG2003	Belongs to the UPF0758 family
H2R00_RS00655	COG1077	Cell shape determining protein MreB Mrl
H2R00_RS00665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2R00_RS00670	COG0850	regulation of cytokinetic process
H2R00_RS00675	COG2894	cell division
H2R00_RS00680	COG0640	Transcriptional regulator
H2R00_RS00685	COG3832	glyoxalase III activity
H2R00_RS00690	COG0739	heme binding
H2R00_RS00695	COG1994	Peptidase M50
H2R00_RS00700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2R00_RS00705	COG2868	ribosomal protein
H2R00_RS00710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2R00_RS00715	COG3290	protein histidine kinase activity
H2R00_RS00720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2R00_RS00725	COG4492	Belongs to the UPF0735 family
H2R00_RS00730	COG0077	Prephenate dehydratase
H2R00_RS00735	COG1827	regulation of RNA biosynthetic process
H2R00_RS00740	COG1104	cysteine desulfurase activity
H2R00_RS00745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2R00_RS00750	COG0157	Belongs to the NadC ModD family
H2R00_RS00755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2R00_RS00760	COG1388	LysM domain
H2R00_RS00770	COG0217	transcriptional regulatory protein
H2R00_RS00785	COG4195	phage-related replication protein
H2R00_RS00790	COG2318	DinB family
H2R00_RS00800	COG2112	serine threonine protein kinase
H2R00_RS00810	COG0632	four-way junction helicase activity
H2R00_RS00815	COG2255	four-way junction helicase activity
H2R00_RS00825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H2R00_RS00830	COG0343	queuine tRNA-ribosyltransferase activity
H2R00_RS00835	COG1862	Preprotein translocase
H2R00_RS00845	COG2323	membrane
H2R00_RS00850	COG2244	polysaccharide biosynthetic process
H2R00_RS00860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2R00_RS00860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2R00_RS00865	COG5416	Lipopolysaccharide assembly protein A domain
H2R00_RS00870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H2R00_RS00870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2R00_RS00875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2R00_RS00880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2R00_RS00885	COG1490	D-aminoacyl-tRNA deacylase activity
H2R00_RS00890	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2R00_RS00890	COG3103	Sh3 type 3 domain protein
H2R00_RS00890	COG4991	sh3 domain protein
H2R00_RS00900	COG0124	histidyl-tRNA synthetase
H2R00_RS00905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2R00_RS00915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2R00_RS00920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2R00_RS00925	COG1959	2 iron, 2 sulfur cluster binding
H2R00_RS00930	COG1104	cysteine desulfurase activity
H2R00_RS00935	COG0482	sulfurtransferase activity
H2R00_RS00940	COG0457	Tetratricopeptide repeat
H2R00_RS00945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2R00_RS00950	COG3881	PFAM PRC-barrel domain
H2R00_RS00965	COG0628	permease
H2R00_RS00970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H2R00_RS00975	COG4472	Bacterial protein of unknown function (DUF965)
H2R00_RS00980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2R00_RS00985	COG3906	Belongs to the UPF0473 family
H2R00_RS00990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2R00_RS00995	COG4122	O-methyltransferase activity
H2R00_RS01010	COG0572	uridine kinase
H2R00_RS01015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2R00_RS01020	COG0768	penicillin binding
H2R00_RS01035	COG2226	methyltransferase
H2R00_RS01040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2R00_RS01045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2R00_RS01050	COG0626	cystathionine gamma-synthase activity
H2R00_RS01075	COG2226	methyltransferase
H2R00_RS01080	COG1404	Belongs to the peptidase S8 family
H2R00_RS01085	COG1309	transcriptional regulator
H2R00_RS01090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2R00_RS01090	COG2124	cytochrome p450
H2R00_RS01095	COG0697	spore germination
H2R00_RS01115	COG2814	Major facilitator Superfamily
H2R00_RS01120	COG0583	DNA-binding transcription factor activity
H2R00_RS01125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS01135	COG1587	Uroporphyrinogen-III synthase
H2R00_RS01140	COG3340	Belongs to the peptidase S51 family
H2R00_RS01145	COG1733	regulation of RNA biosynthetic process
H2R00_RS01150	COG2814	Major facilitator Superfamily
H2R00_RS01155	COG0656	L-ascorbic acid biosynthetic process
H2R00_RS01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2R00_RS01165	COG2169	Transcriptional regulator
H2R00_RS01185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H2R00_RS01185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H2R00_RS01190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS01195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS01200	COG3715	PTS system
H2R00_RS01205	COG3716	PTS system mannose fructose sorbose family IID component
H2R00_RS01210	COG1621	beta-fructofuranosidase activity
H2R00_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS01225	COG0730	response to heat
H2R00_RS01230	COG2124	cytochrome p450
H2R00_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS01265	COG4608	Belongs to the ABC transporter superfamily
H2R00_RS01270	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2R00_RS01280	COG0601	transmembrane transport
H2R00_RS01285	COG0747	negative chemotaxis
H2R00_RS01290	COG0492	ferredoxin-NADP+ reductase activity
H2R00_RS01295	COG2197	response regulator
H2R00_RS01300	COG4585	Histidine kinase
H2R00_RS01305	COG3239	Fatty acid desaturase
H2R00_RS01310	COG1733	regulation of RNA biosynthetic process
H2R00_RS01315	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H2R00_RS01320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2R00_RS01325	COG1942	4-Oxalocrotonate Tautomerase
H2R00_RS01340	COG0113	porphobilinogen synthase activity
H2R00_RS01385	COG1937	Protein conserved in bacteria
H2R00_RS01390	COG2210	Belongs to the sulfur carrier protein TusA family
H2R00_RS01395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2R00_RS01395	COG0425	Belongs to the sulfur carrier protein TusA family
H2R00_RS01400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS01400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2R00_RS01405	COG0425	Belongs to the sulfur carrier protein TusA family
H2R00_RS01410	COG0730	response to heat
H2R00_RS01415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS01420	COG4585	Histidine kinase
H2R00_RS01425	COG2197	response regulator
H2R00_RS01435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS01485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS01495	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS01510	COG4978	Transcriptional regulator
H2R00_RS01510	COG0789	Transcriptional regulator
H2R00_RS01530	COG2807	transmembrane transport
H2R00_RS01540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS01555	COG2427	Protein of unknown function (DUF1641)
H2R00_RS01560	COG3383	formate dehydrogenase (NAD+) activity
H2R00_RS01565	COG5609	conserved protein (DUF2294)
H2R00_RS01575	COG2755	lipolytic protein G-D-S-L family
H2R00_RS01590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H2R00_RS01595	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H2R00_RS01600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2R00_RS01605	COG1534	Rna-binding protein
H2R00_RS01610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H2R00_RS01615	COG1713	HD superfamily hydrolase involved in NAD metabolism
H2R00_RS01620	COG0799	negative regulation of ribosome biogenesis
H2R00_RS01625	COG2226	methyltransferase
H2R00_RS01630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2R00_RS01635	COG1555	photosystem II stabilization
H2R00_RS01635	COG1596	polysaccharide export
H2R00_RS01640	COG2131	deaminase
H2R00_RS01645	COG2333	competence protein COMEC
H2R00_RS01645	COG0658	competence protein
H2R00_RS01655	COG1466	dna polymerase III delta subunit
H2R00_RS01660	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS01665	COG1733	regulation of RNA biosynthetic process
H2R00_RS01675	COG0268	Binds directly to 16S ribosomal RNA
H2R00_RS01680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H2R00_RS01685	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2R00_RS01695	COG0481	GTPase activity
H2R00_RS01700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2R00_RS01705	COG1420	regulation of RNA biosynthetic process
H2R00_RS01710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2R00_RS01715	COG0443	Heat shock 70 kDa protein
H2R00_RS01720	COG0484	heat shock protein binding
H2R00_RS01725	COG2264	protein methyltransferase activity
H2R00_RS01730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2R00_RS01735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2R00_RS01740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2R00_RS01745	COG1283	sodium-dependent phosphate transmembrane transporter activity
H2R00_RS01750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H2R00_RS01755	COG1610	YqeY-like protein
H2R00_RS01760	COG1030	water channel activity
H2R00_RS01765	COG4864	UPF0365 protein
H2R00_RS01780	COG0561	phosphatase activity
H2R00_RS01785	COG1702	phosphate starvation-inducible protein PhoH
H2R00_RS01790	COG1480	7TM receptor with intracellular HD hydrolase
H2R00_RS01795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2R00_RS01800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H2R00_RS01805	COG0295	cytidine deaminase activity
H2R00_RS01810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2R00_RS01820	COG1381	Involved in DNA repair and RecF pathway recombination
H2R00_RS01825	COG0752	glycyl-tRNA synthetase alpha subunit
H2R00_RS01830	COG0751	glycine-tRNA ligase activity
H2R00_RS01835	COG0517	IMP dehydrogenase activity
H2R00_RS01840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H2R00_RS01845	COG1671	Belongs to the UPF0178 family
H2R00_RS01850	COG0358	DNA primase activity
H2R00_RS01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2R00_RS01865	COG2010	Cytochrome c
H2R00_RS01880	COG5444	nuclease activity
H2R00_RS01925	COG2384	SAM-dependent methyltransferase
H2R00_RS01930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2R00_RS01935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2R00_RS01945	COG0513	Belongs to the DEAD box helicase family
H2R00_RS01950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H2R00_RS01960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS01965	COG1121	(ABC) transporter
H2R00_RS01970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2R00_RS01975	COG0735	belongs to the Fur family
H2R00_RS01980	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H2R00_RS01985	COG4709	membrane
H2R00_RS01990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2R00_RS01995	COG1388	LysM domain
H2R00_RS02000	COG5521	maltodextrose utilization protein MalA
H2R00_RS02005	COG2839	Protein conserved in bacteria
H2R00_RS02010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2R00_RS02015	COG0477	Major facilitator Superfamily
H2R00_RS02025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2R00_RS02030	COG0573	inorganic phosphate transmembrane transporter activity
H2R00_RS02035	COG0581	inorganic phosphate transmembrane transporter activity
H2R00_RS02040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2R00_RS02045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2R00_RS02070	COG1131	(ABC) transporter
H2R00_RS02090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2R00_RS02105	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS02110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2R00_RS02115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2R00_RS02125	COG0457	Tetratricopeptide repeat
H2R00_RS02125	COG0705	Rhomboid family
H2R00_RS02130	COG0697	spore germination
H2R00_RS02135	COG4483	Protein conserved in bacteria
H2R00_RS02140	COG1940	carbohydrate kinase activity
H2R00_RS02145	COG1368	sulfuric ester hydrolase activity
H2R00_RS02150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS02155	COG2866	Carboxypeptidase
H2R00_RS02165	COG0011	TIGRFAM Protein of
H2R00_RS02175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS02185	COG1393	Belongs to the ArsC family
H2R00_RS02195	COG1366	Belongs to the anti-sigma-factor antagonist family
H2R00_RS02200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2R00_RS02205	COG1459	type II secretion system
H2R00_RS02210	COG4537	Required for transformation and DNA binding
H2R00_RS02215	COG4970	Tfp pilus assembly protein FimT
H2R00_RS02225	COG4940	Competence protein ComGF
H2R00_RS02250	COG0681	Belongs to the peptidase S26 family
H2R00_RS02275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2R00_RS02280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2R00_RS02285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2R00_RS02290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2R00_RS02295	COG0517	IMP dehydrogenase activity
H2R00_RS02295	COG4175	Glycine betaine
H2R00_RS02300	COG4176	ABC-type proline glycine betaine transport system permease component
H2R00_RS02305	COG2113	Glycine betaine
H2R00_RS02310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2R00_RS02315	COG0095	Lipoate-protein ligase
H2R00_RS02320	COG1321	iron dependent repressor
H2R00_RS02325	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2R00_RS02335	COG3872	metal-dependent enzyme
H2R00_RS02345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2R00_RS02350	COG0006	proline dipeptidase activity
H2R00_RS02355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2R00_RS02365	COG3854	ATPases associated with a variety of cellular activities
H2R00_RS02405	COG0511	ligase activity, forming carbon-carbon bonds
H2R00_RS02410	COG0439	Biotin carboxylase
H2R00_RS02415	COG1302	Protein conserved in bacteria
H2R00_RS02420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2R00_RS02425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2R00_RS02430	COG1570	exodeoxyribonuclease VII activity
H2R00_RS02435	COG1722	exodeoxyribonuclease VII activity
H2R00_RS02440	COG0142	geranyltranstransferase activity
H2R00_RS02445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2R00_RS02450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H2R00_RS02455	COG1438	arginine binding
H2R00_RS02460	COG0497	DNA recombination
H2R00_RS02465	COG0750	zinc metalloprotease
H2R00_RS02470	COG0745	RESPONSE REGULATOR receiver
H2R00_RS02485	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2R00_RS02490	COG0584	glycerophosphoryl diester phosphodiesterase
H2R00_RS02500	COG3290	protein histidine kinase activity
H2R00_RS02500	COG3829	transcription factor binding
H2R00_RS02505	COG0280	phosphate acetyltransferase
H2R00_RS02515	COG3426	butyrate kinase activity
H2R00_RS02520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2R00_RS02525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2R00_RS02530	COG0022	dehydrogenase e1 component
H2R00_RS02535	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2R00_RS02540	COG1597	lipid kinase activity
H2R00_RS02550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2R00_RS02555	COG0765	amino acid transport
H2R00_RS02560	COG1126	abc transporter atp-binding protein
H2R00_RS02565	COG4129	membrane
H2R00_RS02575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2R00_RS02580	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2R00_RS02585	COG0706	membrane insertase activity
H2R00_RS02595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2R00_RS02600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H2R00_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS02610	COG1785	Belongs to the alkaline phosphatase family
H2R00_RS02615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS02620	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2R00_RS02625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS02630	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS02635	COG2188	Transcriptional regulator
H2R00_RS02640	COG2358	TRAP transporter, solute receptor (TAXI family
H2R00_RS02655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2R00_RS02660	COG1234	tRNA 3'-trailer cleavage
H2R00_RS02670	COG0596	Alpha beta hydrolase
H2R00_RS02675	COG1902	pentaerythritol trinitrate reductase activity
H2R00_RS02680	COG4187	Peptidase family M20/M25/M40
H2R00_RS02685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2R00_RS02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS02695	COG0300	oxidoreductase activity
H2R00_RS02705	COG4195	phage-related replication protein
H2R00_RS02715	COG2814	Major facilitator Superfamily
H2R00_RS02720	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2R00_RS02740	COG0745	RESPONSE REGULATOR receiver
H2R00_RS02745	COG2205	protein histidine kinase activity
H2R00_RS02770	COG1131	(ABC) transporter
H2R00_RS02780	COG1072	(Pantothenic acid kinase))
H2R00_RS02785	COG0346	lactoylglutathione lyase activity
H2R00_RS02790	COG2211	Major facilitator Superfamily
H2R00_RS02800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2R00_RS02815	COG0534	Mate efflux family protein
H2R00_RS02825	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS02835	COG0601	transmembrane transport
H2R00_RS02840	COG0747	negative chemotaxis
H2R00_RS02850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H2R00_RS02860	COG2329	Antibiotic biosynthesis monooxygenase
H2R00_RS02865	COG0456	acetyltransferase
H2R00_RS02865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2R00_RS02875	COG4918	Iron-sulphur cluster biosynthesis
H2R00_RS02885	COG1073	alpha beta
H2R00_RS02895	COG0667	Aldo Keto reductase
H2R00_RS02905	COG1309	transcriptional regulator
H2R00_RS02915	COG0494	nUDIX hydrolase
H2R00_RS02920	COG1379	DNA repair
H2R00_RS02925	COG2153	protein acetylation
H2R00_RS02940	COG1953	Uracil, thiamine, allantoin
H2R00_RS02950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS02955	COG1300	Membrane
H2R00_RS02960	COG0735	belongs to the Fur family
H2R00_RS02970	COG4974	Belongs to the 'phage' integrase family
H2R00_RS02975	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H2R00_RS02980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H2R00_RS02985	COG1686	Belongs to the peptidase S11 family
H2R00_RS03020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2R00_RS03035	COG0697	spore germination
H2R00_RS03045	COG0019	diaminopimelate decarboxylase activity
H2R00_RS03055	COG4195	phage-related replication protein
H2R00_RS03060	COG4086	secreted protein
H2R00_RS03065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2R00_RS03070	COG0457	Tetratricopeptide repeat
H2R00_RS03095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2R00_RS03095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2R00_RS03100	COG0307	riboflavin synthase, alpha
H2R00_RS03105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2R00_RS03105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2R00_RS03110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H2R00_RS03115	COG0456	acetyltransferase
H2R00_RS03120	COG1547	Domain of unknown function (DUF309)
H2R00_RS03130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2R00_RS03135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2R00_RS03145	COG1686	Belongs to the peptidase S11 family
H2R00_RS03150	COG2715	membrane protein required for spore maturation
H2R00_RS03155	COG0700	Nucleoside recognition
H2R00_RS03160	COG1187	pseudouridine synthase activity
H2R00_RS03165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS03170	COG1333	cytochrome c biogenesis protein
H2R00_RS03175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2R00_RS03180	COG0745	RESPONSE REGULATOR receiver
H2R00_RS03185	COG5002	protein histidine kinase activity
H2R00_RS03190	COG0745	RESPONSE REGULATOR receiver
H2R00_RS03195	COG5002	protein histidine kinase activity
H2R00_RS03210	COG1316	TRANSCRIPTIONal
H2R00_RS03215	COG1595	DNA-templated transcription, initiation
H2R00_RS03225	COG0739	heme binding
H2R00_RS03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2R00_RS03235	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H2R00_RS03240	COG1141	Ferredoxin
H2R00_RS03245	COG4955	Helix-turn-helix domain
H2R00_RS03250	COG0514	ATP-dependent DNA helicase (RecQ)
H2R00_RS03255	COG1266	CAAX protease self-immunity
H2R00_RS03260	COG1388	LysM domain
H2R00_RS03270	COG1408	metallophosphoesterase
H2R00_RS03275	COG4862	establishment of competence for transformation
H2R00_RS03280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2R00_RS03285	COG0492	ferredoxin-NADP+ reductase activity
H2R00_RS03295	COG2339	peptidase activity
H2R00_RS03300	COG3773	Cell wall hydrolase
H2R00_RS03300	COG3409	Peptidoglycan-binding domain 1 protein
H2R00_RS03305	COG2959	enzyme of heme biosynthesis
H2R00_RS03315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2R00_RS03320	COG0539	negative regulation of cytoplasmic translation
H2R00_RS03325	COG1304	FMN binding
H2R00_RS03350	COG1160	GTP binding
H2R00_RS03355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H2R00_RS03370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2R00_RS03375	COG0776	regulation of translation
H2R00_RS03390	COG0142	geranyltranstransferase activity
H2R00_RS03395	COG2226	methyltransferase
H2R00_RS03400	COG0142	geranyltranstransferase activity
H2R00_RS03405	COG0105	UTP biosynthetic process
H2R00_RS03410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H2R00_RS03415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H2R00_RS03420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2R00_RS03425	COG4401	Chorismate mutase type I
H2R00_RS03430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2R00_RS03435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2R00_RS03440	COG0134	indole-3-glycerol-phosphate synthase activity
H2R00_RS03445	COG0135	phosphoribosylanthranilate isomerase activity
H2R00_RS03450	COG0133	tryptophan synthase activity
H2R00_RS03455	COG0159	tryptophan synthase activity
H2R00_RS03460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2R00_RS03465	COG0287	Prephenate dehydrogenase
H2R00_RS03470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2R00_RS03475	COG0457	Tetratricopeptide repeat
H2R00_RS03480	COG5582	Belongs to the UPF0302 family
H2R00_RS03490	COG0723	plastoquinol--plastocyanin reductase activity
H2R00_RS03495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2R00_RS03500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2R00_RS03500	COG2010	Cytochrome c
H2R00_RS03510	COG4347	Protein of unknown function (DUF1405)
H2R00_RS03520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS03525	COG1694	Mazg nucleotide pyrophosphohydrolase
H2R00_RS03530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2R00_RS03535	COG1803	Methylglyoxal synthase
H2R00_RS03540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2R00_RS03545	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS03550	COG0617	tRNA 3'-terminal CCA addition
H2R00_RS03560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H2R00_RS03565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2R00_RS03570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2R00_RS03575	COG1199	ATP-dependent helicase activity
H2R00_RS03575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2R00_RS03585	COG5353	protein conserved in bacteria
H2R00_RS03590	COG0436	Aminotransferase
H2R00_RS03595	COG0017	Asparaginyl-tRNA synthetase
H2R00_RS03600	COG3935	DnaD domain protein
H2R00_RS03605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2R00_RS03615	COG4499	WXG100 protein secretion system (Wss), protein YukC
H2R00_RS03615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2R00_RS03620	COG3331	DNA recombination
H2R00_RS03655	COG0071	Belongs to the small heat shock protein (HSP20) family
H2R00_RS03660	COG2190	(PTS) system
H2R00_RS03665	COG1205	dead DEAH box helicase
H2R00_RS03665	COG1111	helicase
H2R00_RS03670	COG3359	exonuclease
H2R00_RS03680	COG4474	Belongs to the UPF0398 family
H2R00_RS03685	COG3599	regulation of cell shape
H2R00_RS03695	COG0116	Belongs to the methyltransferase superfamily
H2R00_RS03710	COG1199	ATP-dependent helicase activity
H2R00_RS03715	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H2R00_RS03720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2R00_RS03725	COG2233	PERMEase
H2R00_RS03735	COG3424	synthase
H2R00_RS03740	COG1755	Isoprenylcysteine carboxyl methyltransferase
H2R00_RS03750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2R00_RS03765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2R00_RS03775	COG0328	RNA-DNA hybrid ribonuclease activity
H2R00_RS03780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H2R00_RS03785	COG0328	RNA-DNA hybrid ribonuclease activity
H2R00_RS03805	COG1278	Cold shock
H2R00_RS03815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2R00_RS03820	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H2R00_RS03825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H2R00_RS03830	COG0386	Belongs to the glutathione peroxidase family
H2R00_RS03835	COG1418	mRNA catabolic process
H2R00_RS03845	COG0129	dihydroxy-acid dehydratase activity
H2R00_RS03855	COG2136	Putative SAM-dependent methyltransferase
H2R00_RS03855	COG2521	methyltransferase
H2R00_RS03865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2R00_RS03870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H2R00_RS03875	COG0204	Acyl-transferase
H2R00_RS03880	COG1272	protein, Hemolysin III
H2R00_RS03885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H2R00_RS03890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2R00_RS03905	COG1999	signal sequence binding
H2R00_RS03910	COG2755	lipolytic protein G-D-S-L family
H2R00_RS03915	COG4698	Protein conserved in bacteria
H2R00_RS03930	COG0534	Mate efflux family protein
H2R00_RS03935	COG3706	GGDEF domain
H2R00_RS03945	COG1846	Transcriptional regulator
H2R00_RS03950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2R00_RS03955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2R00_RS03970	COG0456	acetyltransferase
H2R00_RS03985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2R00_RS03990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2R00_RS03995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2R00_RS04000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2R00_RS04005	COG0456	acetyltransferase
H2R00_RS04010	COG1509	lysine 2,3-aminomutase activity
H2R00_RS04020	COG4479	Belongs to the UPF0346 family
H2R00_RS04035	COG0671	phosphoesterase, PA-phosphatase related
H2R00_RS04055	COG0701	Predicted permease
H2R00_RS04060	COG0813	purine-nucleoside phosphorylase activity
H2R00_RS04065	COG1876	peptidase activity
H2R00_RS04075	COG2226	methyltransferase
H2R00_RS04080	COG3409	Peptidoglycan-binding domain 1 protein
H2R00_RS04080	COG0793	Belongs to the peptidase S41A family
H2R00_RS04085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS04095	COG0400	carboxylic ester hydrolase activity
H2R00_RS04100	COG0778	Nitroreductase
H2R00_RS04105	COG1733	regulation of RNA biosynthetic process
H2R00_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS04120	COG4305	rare lipoprotein A
H2R00_RS04130	COG2962	Rard protein
H2R00_RS04140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2R00_RS04145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2R00_RS04150	COG0534	Mate efflux family protein
H2R00_RS04155	COG0791	NLP P60 protein
H2R00_RS04155	COG1388	LysM domain
H2R00_RS04160	COG2032	superoxide dismutase activity
H2R00_RS04165	COG0714	Associated with various cellular activities
H2R00_RS04170	COG4548	von Willebrand factor, type A
H2R00_RS04175	COG0567	Dehydrogenase, E1 component
H2R00_RS04180	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2R00_RS04185	COG0385	Bile acid
H2R00_RS04190	COG0733	neurotransmitter:sodium symporter activity
H2R00_RS04200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2R00_RS04205	COG1657	PFAM Prenyltransferase squalene oxidase
H2R00_RS04230	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS04245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2R00_RS04265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2R00_RS04270	COG2318	DinB family
H2R00_RS04285	COG1309	transcriptional regulator
H2R00_RS04290	COG0574	Belongs to the PEP-utilizing enzyme family
H2R00_RS04290	COG3848	Pyruvate phosphate dikinase
H2R00_RS04300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2R00_RS04305	COG1280	lysine exporter protein (LysE YggA)
H2R00_RS04320	COG2267	carboxylic ester hydrolase activity
H2R00_RS04335	COG0402	S-adenosylhomocysteine deaminase activity
H2R00_RS04380	COG5444	nuclease activity
H2R00_RS04410	COG3383	formate dehydrogenase (NAD+) activity
H2R00_RS04415	COG2427	Protein of unknown function (DUF1641)
H2R00_RS04425	COG2315	Protein conserved in bacteria
H2R00_RS04445	COG0514	ATP-dependent DNA helicase (RecQ)
H2R00_RS04450	COG1388	LysM domain
H2R00_RS04450	COG3584	3D domain protein
H2R00_RS04455	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS04470	COG2322	membrane
H2R00_RS04490	COG1086	Polysaccharide biosynthesis protein
H2R00_RS04495	COG0741	lytic transglycosylase activity
H2R00_RS04500	COG0531	amino acid
H2R00_RS04515	COG0640	Transcriptional regulator
H2R00_RS04525	COG2378	regulation of single-species biofilm formation
H2R00_RS04535	COG3708	Transcriptional regulator
H2R00_RS04540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS04545	COG1309	transcriptional regulator
H2R00_RS04575	COG1846	Transcriptional regulator
H2R00_RS04580	COG1309	transcriptional regulator
H2R00_RS04590	COG1404	Belongs to the peptidase S8 family
H2R00_RS04595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2R00_RS04600	COG0840	transmembrane signaling receptor activity
H2R00_RS04610	COG0697	spore germination
H2R00_RS04615	COG0531	amino acid
H2R00_RS04620	COG0531	amino acid
H2R00_RS04630	COG0531	amino acid
H2R00_RS04635	COG2814	Major facilitator Superfamily
H2R00_RS04640	COG1846	Transcriptional regulator
H2R00_RS04645	COG0243	molybdopterin cofactor binding
H2R00_RS04650	COG0477	Major facilitator Superfamily
H2R00_RS04655	COG3848	Pyruvate phosphate dikinase
H2R00_RS04655	COG0574	Belongs to the PEP-utilizing enzyme family
H2R00_RS04660	COG0300	oxidoreductase activity
H2R00_RS04670	COG1132	(ABC) transporter
H2R00_RS04680	COG1846	Transcriptional regulator
H2R00_RS04695	COG0583	DNA-binding transcription factor activity
H2R00_RS04700	COG0067	glutamate synthase
H2R00_RS04700	COG0070	glutamate synthase
H2R00_RS04700	COG0069	glutamate synthase activity
H2R00_RS04705	COG0493	'glutamate synthase
H2R00_RS04715	COG0463	Glycosyl transferase, family 2
H2R00_RS04720	COG2814	Major facilitator Superfamily
H2R00_RS04725	COG4948	Mandelate Racemase Muconate Lactonizing
H2R00_RS04730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS04735	COG1809	phosphosulfolactate synthase activity
H2R00_RS04740	COG0175	sulfate reduction
H2R00_RS04745	COG0306	phosphate transporter
H2R00_RS04750	COG2323	membrane
H2R00_RS04760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2R00_RS04765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2R00_RS04770	COG1733	regulation of RNA biosynthetic process
H2R00_RS04775	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS04780	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS04785	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS04795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS04800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS04805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS04810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS04815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS04815	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2R00_RS04820	COG0439	Biotin carboxylase
H2R00_RS04825	COG0511	ligase activity, forming carbon-carbon bonds
H2R00_RS04830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2R00_RS04835	COG1024	Enoyl-CoA hydratase
H2R00_RS04840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2R00_RS04845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2R00_RS04855	COG0166	Belongs to the GPI family
H2R00_RS04865	COG1252	NADH dehydrogenase
H2R00_RS04870	COG1309	transcriptional regulator
H2R00_RS04890	COG2027	D-alanyl-D-alanine carboxypeptidase
H2R00_RS04895	COG0297	glycogen (starch) synthase activity
H2R00_RS04905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H2R00_RS04910	COG2404	hydrolase activity, acting on ester bonds
H2R00_RS04915	COG1649	PFAM Uncharacterised BCR, COG1649
H2R00_RS04930	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H2R00_RS04935	COG0640	Transcriptional regulator
H2R00_RS04940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H2R00_RS04945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2R00_RS04950	COG1609	Transcriptional regulator
H2R00_RS04960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H2R00_RS04975	COG1312	Catalyzes the dehydration of D-mannonate
H2R00_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS04985	COG1725	Transcriptional regulator
H2R00_RS05000	COG3711	transcriptional antiterminator
H2R00_RS05000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS05005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS05005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS05010	COG1482	cell wall glycoprotein biosynthetic process
H2R00_RS05015	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS05020	COG2084	Dehydrogenase
H2R00_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS05030	COG1024	Enoyl-CoA hydratase
H2R00_RS05060	COG1114	Component of the transport system for branched-chain amino acids
H2R00_RS05065	COG3420	alginic acid biosynthetic process
H2R00_RS05070	COG0477	Major facilitator Superfamily
H2R00_RS05085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS05095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H2R00_RS05105	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H2R00_RS05125	COG2223	nitrite transmembrane transporter activity
H2R00_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2R00_RS05140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2R00_RS05160	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H2R00_RS05165	COG1140	nitrate reductase beta subunit
H2R00_RS05170	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H2R00_RS05175	COG2181	nitrate reductase activity
H2R00_RS05185	COG1115	amino acid carrier protein
H2R00_RS05205	COG2160	L-arabinose isomerase activity
H2R00_RS05220	COG1609	Transcriptional regulator
H2R00_RS05225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2R00_RS05230	COG0187	DNA topoisomerase II activity
H2R00_RS05235	COG1832	CoA-binding protein
H2R00_RS05240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H2R00_RS05245	COG4841	protein insertion into membrane
H2R00_RS05265	COG0824	Thioesterase
H2R00_RS05285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS05290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2R00_RS05305	COG0071	Belongs to the small heat shock protein (HSP20) family
H2R00_RS05315	COG4846	Membrane protein involved in cytochrome C biogenesis
H2R00_RS05320	COG2201	protein-glutamate methylesterase activity
H2R00_RS05325	COG0785	Cytochrome C biogenesis protein
H2R00_RS05335	COG3763	UPF0154 protein
H2R00_RS05345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2R00_RS05350	COG4224	UPF0291 protein
H2R00_RS05355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H2R00_RS05360	COG1388	LysM domain
H2R00_RS05365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2R00_RS05370	COG3209	COG3209 Rhs family protein
H2R00_RS05395	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS05400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2R00_RS05405	COG0346	lactoylglutathione lyase activity
H2R00_RS05410	COG0778	Nitroreductase
H2R00_RS05415	COG1846	Transcriptional regulator
H2R00_RS05440	COG3546	catalase activity
H2R00_RS05445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS05460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS05465	COG2076	Multidrug Resistance protein
H2R00_RS05470	COG2076	Multidrug Resistance protein
H2R00_RS05475	COG1309	transcriptional regulator
H2R00_RS05505	COG1073	alpha beta
H2R00_RS05625	COG0174	glutamine synthetase
H2R00_RS05630	COG0789	Transcriptional regulator
H2R00_RS05635	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H2R00_RS05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2R00_RS05645	COG0464	growth
H2R00_RS05675	COG0457	Tetratricopeptide repeat
H2R00_RS05680	COG2814	Major facilitator Superfamily
H2R00_RS05690	COG4282	regulation of fungal-type cell wall biogenesis
H2R00_RS05725	COG1309	transcriptional regulator
H2R00_RS05755	COG0697	spore germination
H2R00_RS05760	COG1802	Transcriptional regulator
H2R00_RS05765	COG0735	belongs to the Fur family
H2R00_RS05780	COG4112	unkown
H2R00_RS05785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2R00_RS05790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2R00_RS05795	COG1780	Probably involved in ribonucleotide reductase function
H2R00_RS05805	COG1923	regulation of RNA biosynthetic process
H2R00_RS05810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2R00_RS05825	COG2076	Multidrug Resistance protein
H2R00_RS05830	COG2076	Multidrug Resistance protein
H2R00_RS05835	COG1764	response to oxidative stress
H2R00_RS05845	COG0702	epimerase
H2R00_RS05850	COG3631	Ketosteroid isomerase-related protein
H2R00_RS05855	COG1309	transcriptional regulator
H2R00_RS05860	COG1388	LysM domain
H2R00_RS05860	COG3858	chitin binding
H2R00_RS05875	COG0531	amino acid
H2R00_RS05880	COG1819	glycosyl
H2R00_RS05885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2R00_RS05890	COG0398	Pfam SNARE associated Golgi protein
H2R00_RS05895	COG0393	Putative heavy-metal-binding
H2R00_RS05905	COG2267	carboxylic ester hydrolase activity
H2R00_RS05910	COG2814	Major facilitator Superfamily
H2R00_RS05915	COG3263	regulation of cellular component size
H2R00_RS05920	COG3619	membrane
H2R00_RS05925	COG1231	oxidoreductase activity
H2R00_RS05945	COG0523	cobalamin synthesis protein
H2R00_RS05965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2R00_RS05970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2R00_RS05975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H2R00_RS05985	COG0667	Aldo Keto reductase
H2R00_RS05990	COG1595	DNA-templated transcription, initiation
H2R00_RS05995	COG4550	Control of competence regulator ComK, YlbF/YmcA
H2R00_RS06000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2R00_RS06010	COG1063	alcohol dehydrogenase
H2R00_RS06020	COG2359	stage V sporulation protein S
H2R00_RS06025	COG1692	metallophosphoesterase
H2R00_RS06030	COG1418	mRNA catabolic process
H2R00_RS06040	COG1058	Belongs to the CinA family
H2R00_RS06040	COG1546	Belongs to the CinA family
H2R00_RS06045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2R00_RS06050	COG1426	Protein conserved in bacteria
H2R00_RS06065	COG0300	oxidoreductase activity
H2R00_RS06070	COG0612	Peptidase, M16
H2R00_RS06075	COG0612	Peptidase, M16
H2R00_RS06080	COG2814	Major facilitator Superfamily
H2R00_RS06085	COG2188	Transcriptional regulator
H2R00_RS06090	COG4980	gas vesicle protein
H2R00_RS06090	COG1674	ftsk spoiiie
H2R00_RS06100	COG0740	serine-type endopeptidase activity
H2R00_RS06105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2R00_RS06115	COG0527	aspartate kinase activity
H2R00_RS06120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2R00_RS06125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2R00_RS06130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2R00_RS06135	COG1873	PFAM PRC-barrel domain
H2R00_RS06140	COG0612	Peptidase, M16
H2R00_RS06145	COG0726	polysaccharide deacetylase
H2R00_RS06150	COG1185	polyribonucleotide nucleotidyltransferase activity
H2R00_RS06155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2R00_RS06160	COG0196	riboflavin kinase activity
H2R00_RS06165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2R00_RS06170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2R00_RS06175	COG1550	Protein conserved in bacteria
H2R00_RS06180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2R00_RS06185	COG1358	cellular component organization or biogenesis
H2R00_RS06190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H2R00_RS06195	COG0195	Participates in both transcription termination and antitermination
H2R00_RS06200	COG0779	Required for maturation of 30S ribosomal subunits
H2R00_RS06225	COG2176	DNA-directed DNA polymerase activity
H2R00_RS06230	COG0442	prolyl-tRNA aminoacylation
H2R00_RS06235	COG0750	zinc metalloprotease
H2R00_RS06240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H2R00_RS06245	COG4589	Belongs to the CDS family
H2R00_RS06250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2R00_RS06255	COG0233	cytoplasmic translational termination
H2R00_RS06260	COG0528	UMP kinase activity
H2R00_RS06265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2R00_RS06270	COG0052	Belongs to the universal ribosomal protein uS2 family
H2R00_RS06280	COG1191	sigma factor activity
H2R00_RS06285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H2R00_RS06290	COG1776	CheC inhibitor of MCP methylation
H2R00_RS06295	COG0835	chemotaxis
H2R00_RS06300	COG0643	Histidine kinase
H2R00_RS06300	COG2198	Histidine kinase
H2R00_RS06305	COG2201	protein-glutamate methylesterase activity
H2R00_RS06310	COG0455	bacterial-type flagellum organization
H2R00_RS06315	COG1419	protein localization to endoplasmic reticulum
H2R00_RS06320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2R00_RS06325	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2R00_RS06330	COG1684	flagellar biosynthetic protein fliR
H2R00_RS06335	COG1987	bacterial-type flagellum assembly
H2R00_RS06340	COG1338	Plays a role in the flagellum-specific transport system
H2R00_RS06345	COG3190	flagellar
H2R00_RS06350	COG2201	protein-glutamate methylesterase activity
H2R00_RS06355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2R00_RS06355	COG1776	CheC inhibitor of MCP methylation
H2R00_RS06360	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2R00_RS06365	COG1580	Controls the rotational direction of flagella during chemotaxis
H2R00_RS06370	COG1582	Flagellar protein (FlbD)
H2R00_RS06375	COG4786	Flagellar basal body rod
H2R00_RS06380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H2R00_RS06385	COG3144	bacterial-type flagellum assembly
H2R00_RS06395	COG2882	bacterial-type flagellum organization
H2R00_RS06400	COG1157	protein secretion by the type III secretion system
H2R00_RS06405	COG1317	bacterial-type flagellum organization
H2R00_RS06410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2R00_RS06415	COG1766	The M ring may be actively involved in energy transduction
H2R00_RS06420	COG1677	Flagellar hook-basal body complex protein FliE
H2R00_RS06425	COG1558	bacterial-type flagellum-dependent cell motility
H2R00_RS06430	COG1815	bacterial-type flagellum-dependent cell motility
H2R00_RS06435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H2R00_RS06440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H2R00_RS06445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H2R00_RS06450	COG4974	Belongs to the 'phage' integrase family
H2R00_RS06455	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H2R00_RS06460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2R00_RS06465	COG0758	DNA mediated transformation
H2R00_RS06470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2R00_RS06475	COG0045	succinate-CoA ligase (ADP-forming) activity
H2R00_RS06480	COG2257	FlhB HrpN YscU SpaS Family
H2R00_RS06490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2R00_RS06495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H2R00_RS06500	COG0335	large ribosomal subunit rRNA binding
H2R00_RS06505	COG0336	Belongs to the RNA methyltransferase TrmD family
H2R00_RS06510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2R00_RS06520	COG1837	Belongs to the UPF0109 family
H2R00_RS06525	COG0228	four-way junction DNA binding
H2R00_RS06530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2R00_RS06535	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H2R00_RS06540	COG0552	protein localization to endoplasmic reticulum
H2R00_RS06545	COG1196	nuclear chromosome segregation
H2R00_RS06550	COG0571	ribonuclease III activity
H2R00_RS06555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2R00_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS06565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2R00_RS06570	COG0416	fatty acid biosynthetic process
H2R00_RS06575	COG1349	DNA-binding transcription factor activity
H2R00_RS06580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2R00_RS06585	COG1760	l-serine dehydratase
H2R00_RS06590	COG1760	l-serine dehydratase
H2R00_RS06595	COG1461	Dihydroxyacetone kinase
H2R00_RS06600	COG1302	Protein conserved in bacteria
H2R00_RS06605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2R00_RS06615	COG1564	THIamine pyrophosphokinase
H2R00_RS06620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2R00_RS06625	COG1162	GTPase activity
H2R00_RS06630	COG2815	serine threonine protein kinase
H2R00_RS06630	COG0515	serine threonine protein kinase
H2R00_RS06635	COG0631	protein serine/threonine phosphatase activity
H2R00_RS06640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2R00_RS06645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2R00_RS06645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2R00_RS06650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2R00_RS06655	COG0242	peptide deformylase activity
H2R00_RS06660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2R00_RS06665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2R00_RS06670	COG1758	RNA polymerase activity
H2R00_RS06675	COG0194	GDP metabolic process
H2R00_RS06680	COG2052	Domain of unknown function (DUF370)
H2R00_RS06685	COG1561	YicC-like family, N-terminal region
H2R00_RS06690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2R00_RS06700	COG1648	precorrin-2 dehydrogenase activity
H2R00_RS06705	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H2R00_RS06710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2R00_RS06715	COG0529	Catalyzes the synthesis of activated sulfate
H2R00_RS06720	COG2046	Belongs to the sulfate adenylyltransferase family
H2R00_RS06725	COG0306	phosphate transporter
H2R00_RS06730	COG0175	sulfate reduction
H2R00_RS06740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2R00_RS06745	COG0284	orotidine-5'-phosphate decarboxylase activity
H2R00_RS06750	COG0167	dihydroorotate dehydrogenase activity
H2R00_RS06755	COG0543	2 iron, 2 sulfur cluster binding
H2R00_RS06760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2R00_RS06765	COG0505	Belongs to the CarA family
H2R00_RS06770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2R00_RS06775	COG0540	Belongs to the ATCase OTCase family
H2R00_RS06780	COG2233	PERMEase
H2R00_RS06790	COG0564	pseudouridine synthase activity
H2R00_RS06795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2R00_RS06800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2R00_RS06805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2R00_RS06810	COG3599	regulation of cell shape
H2R00_RS06815	COG2302	S4 RNA-binding domain
H2R00_RS06820	COG0762	integral membrane protein
H2R00_RS06825	COG1799	cell septum assembly
H2R00_RS06830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H2R00_RS06840	COG1873	PFAM PRC-barrel domain
H2R00_RS06845	COG0500	methyltransferase
H2R00_RS06850	COG1119	ATPase activity
H2R00_RS06855	COG1191	sigma factor activity
H2R00_RS06860	COG1191	sigma factor activity
H2R00_RS06870	COG1404	Belongs to the peptidase S8 family
H2R00_RS06870	COG4412	M6 family metalloprotease domain protein
H2R00_RS06875	COG1404	Belongs to the peptidase S8 family
H2R00_RS06875	COG4412	M6 family metalloprotease domain protein
H2R00_RS06880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2R00_RS06885	COG0849	cell division
H2R00_RS06890	COG3856	small basic protein
H2R00_RS06895	COG3879	Bacterial protein of unknown function (DUF881)
H2R00_RS06900	COG3879	Bacterial protein of unknown function (DUF881)
H2R00_RS06905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2R00_RS06910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2R00_RS06915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2R00_RS06920	COG0772	Belongs to the SEDS family
H2R00_RS06925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2R00_RS06930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2R00_RS06935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2R00_RS06940	COG0768	penicillin binding
H2R00_RS06950	COG4839	cell division protein FtsL
H2R00_RS06955	COG0275	rRNA processing
H2R00_RS06960	COG2001	Belongs to the MraZ family
H2R00_RS06965	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H2R00_RS06970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2R00_RS06975	COG0454	-acetyltransferase
H2R00_RS06985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2R00_RS06990	COG1399	metal-binding, possibly nucleic acid-binding protein
H2R00_RS06995	COG1323	Belongs to the UPF0348 family
H2R00_RS07000	COG3480	Lon protease (S16) C-terminal proteolytic domain
H2R00_RS07005	COG3314	Sporulation integral membrane protein YlbJ
H2R00_RS07010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2R00_RS07015	COG0742	ribosomal rna small subunit methyltransferase
H2R00_RS07025	COG4471	UPF0298 protein
H2R00_RS07030	COG3679	Belongs to the UPF0342 family
H2R00_RS07045	COG2340	Cysteine-rich secretory protein family
H2R00_RS07050	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H2R00_RS07060	COG3336	cytochrome c oxidase
H2R00_RS07065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2R00_RS07070	COG1845	cytochrome c oxidase, subunit III
H2R00_RS07075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2R00_RS07080	COG2010	Cytochrome c
H2R00_RS07080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2R00_RS07085	COG0109	protoheme IX farnesyltransferase activity
H2R00_RS07090	COG1612	heme a metabolic process
H2R00_RS07095	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H2R00_RS07100	COG0772	Belongs to the SEDS family
H2R00_RS07105	COG4838	Belongs to the UPF0358 family
H2R00_RS07110	COG2066	Belongs to the glutaminase family
H2R00_RS07115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2R00_RS07120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H2R00_RS07130	COG4896	Protein conserved in bacteria
H2R00_RS07135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2R00_RS07140	COG1846	Transcriptional regulator
H2R00_RS07165	COG0483	inositol monophosphate 1-phosphatase activity
H2R00_RS07175	COG4493	Belongs to the UPF0637 family
H2R00_RS07180	COG4476	Belongs to the UPF0223 family
H2R00_RS07185	COG1982	Orn Lys Arg decarboxylase major
H2R00_RS07195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS07200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2R00_RS07205	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2R00_RS07210	COG0022	dehydrogenase e1 component
H2R00_RS07215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2R00_RS07220	COG0497	DNA recombination
H2R00_RS07230	COG0242	peptide deformylase activity
H2R00_RS07235	COG0561	phosphatase activity
H2R00_RS07245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2R00_RS07250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2R00_RS07255	COG0569	domain protein
H2R00_RS07260	COG3852	Histidine kinase
H2R00_RS07265	COG2002	toxin-antitoxin pair type II binding
H2R00_RS07270	COG1077	Cell shape determining protein MreB Mrl
H2R00_RS07280	COG2309	aminopeptidase activity
H2R00_RS07290	COG0488	(ABC) transporter
H2R00_RS07310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS07310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS07310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS07315	COG1105	Belongs to the carbohydrate kinase PfkB family
H2R00_RS07320	COG1349	DNA-binding transcription factor activity
H2R00_RS07330	COG0577	efflux transmembrane transporter activity
H2R00_RS07335	COG1136	(ABC) transporter
H2R00_RS07340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2R00_RS07350	COG1132	(ABC) transporter
H2R00_RS07355	COG1132	(ABC) transporter
H2R00_RS07365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H2R00_RS07370	COG0314	molybdopterin synthase activity
H2R00_RS07375	COG1763	Mo-molybdopterin cofactor biosynthetic process
H2R00_RS07380	COG0303	'Molybdopterin
H2R00_RS07385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2R00_RS07390	COG0746	molybdenum cofactor guanylyltransferase activity
H2R00_RS07405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS07410	COG0450	alkyl hydroperoxide reductase
H2R00_RS07420	COG1473	amidohydrolase
H2R00_RS07425	COG2171	N-acyltransferase activity
H2R00_RS07430	COG0716	FMN binding
H2R00_RS07440	COG0716	FMN binding
H2R00_RS07445	COG0583	DNA-binding transcription factor activity
H2R00_RS07450	COG0517	IMP dehydrogenase activity
H2R00_RS07460	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H2R00_RS07465	COG4703	Protein of unknown function (DUF1797)
H2R00_RS07475	COG2200	EAL domain
H2R00_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS07485	COG1408	metallophosphoesterase
H2R00_RS07490	COG1376	ErfK ybiS ycfS ynhG family protein
H2R00_RS07495	COG2814	Major facilitator Superfamily
H2R00_RS07505	COG0784	Response regulator, receiver
H2R00_RS07505	COG0835	chemotaxis
H2R00_RS07515	COG1714	RDD family
H2R00_RS07525	COG0436	Aminotransferase
H2R00_RS07530	COG4191	Histidine kinase
H2R00_RS07535	COG0768	penicillin binding
H2R00_RS07540	COG2340	Cysteine-rich secretory protein family
H2R00_RS07545	COG2084	Dehydrogenase
H2R00_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS07555	COG0840	transmembrane signaling receptor activity
H2R00_RS07560	COG0456	acetyltransferase
H2R00_RS07565	COG1533	DNA photolyase activity
H2R00_RS07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2R00_RS07580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS07585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS07585	COG2190	(PTS) system
H2R00_RS07585	COG1263	PTS System
H2R00_RS07590	COG3711	transcriptional antiterminator
H2R00_RS07595	COG1609	Transcriptional regulator
H2R00_RS07605	COG0006	proline dipeptidase activity
H2R00_RS07610	COG2217	Heavy metal translocating P-type atpase
H2R00_RS07615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS07620	COG2244	polysaccharide biosynthetic process
H2R00_RS07625	COG3773	Cell wall hydrolase
H2R00_RS07635	COG4873	Protein conserved in bacteria
H2R00_RS07670	COG3655	Transcriptional regulator
H2R00_RS07675	COG3739	integral membrane protein
H2R00_RS07680	COG0457	Tetratricopeptide repeat
H2R00_RS07685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H2R00_RS07690	COG0602	queuosine metabolic process
H2R00_RS07695	COG0720	synthase
H2R00_RS07700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2R00_RS07705	COG3949	Membrane
H2R00_RS07710	COG0542	response to heat
H2R00_RS07715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H2R00_RS07720	COG1360	Flagellar Motor Protein
H2R00_RS07725	COG1846	Transcriptional regulator
H2R00_RS07730	COG3852	Histidine kinase
H2R00_RS07740	COG3339	Conserved Protein
H2R00_RS07745	COG0346	lactoylglutathione lyase activity
H2R00_RS07750	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H2R00_RS07755	COG0235	Class ii aldolase
H2R00_RS07755	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H2R00_RS07760	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H2R00_RS07760	COG0235	Class ii aldolase
H2R00_RS07765	COG1850	ribulose-bisphosphate carboxylase activity
H2R00_RS07770	COG0436	Aminotransferase
H2R00_RS07775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2R00_RS07780	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H2R00_RS07785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H2R00_RS07790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2R00_RS07795	COG5002	protein histidine kinase activity
H2R00_RS07800	COG3594	Acyltransferase
H2R00_RS07815	COG0768	penicillin binding
H2R00_RS07820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2R00_RS07825	COG0501	Belongs to the peptidase M48B family
H2R00_RS07845	COG1191	sigma factor activity
H2R00_RS07850	COG0861	Integral membrane protein TerC family
H2R00_RS07855	COG0586	Pfam SNARE associated Golgi protein
H2R00_RS07860	COG5001	Diguanylate cyclase
H2R00_RS07860	COG3300	MHYT domain
H2R00_RS07865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H2R00_RS07870	COG1793	dna ligase
H2R00_RS07870	COG3285	dna ligase
H2R00_RS07875	COG1846	Transcriptional regulator
H2R00_RS07890	COG0789	Transcriptional regulator
H2R00_RS07900	COG2239	Acts as a magnesium transporter
H2R00_RS07910	COG1404	Belongs to the peptidase S8 family
H2R00_RS07915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2R00_RS07930	COG0406	alpha-ribazole phosphatase activity
H2R00_RS07935	COG0590	tRNA wobble adenosine to inosine editing
H2R00_RS07945	COG1764	response to oxidative stress
H2R00_RS07950	COG1846	Transcriptional regulator
H2R00_RS07955	COG1764	response to oxidative stress
H2R00_RS07960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2R00_RS07965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2R00_RS07970	COG0788	formyltetrahydrofolate deformylase activity
H2R00_RS07975	COG2076	Multidrug Resistance protein
H2R00_RS07980	COG2076	Multidrug Resistance protein
H2R00_RS07985	COG2318	DinB family
H2R00_RS08005	COG3866	Pectate lyase
H2R00_RS08010	COG2323	membrane
H2R00_RS08015	COG1607	acyl-coa hydrolase
H2R00_RS08020	COG1834	amidinotransferase
H2R00_RS08025	COG4608	Belongs to the ABC transporter superfamily
H2R00_RS08030	COG0791	NLP P60 protein
H2R00_RS08035	COG4948	Mandelate Racemase Muconate Lactonizing
H2R00_RS08040	COG1619	proteins homologs of microcin C7 resistance protein MccF
H2R00_RS08045	COG4166	transmembrane transport
H2R00_RS08050	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS08055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2R00_RS08060	COG0601	transmembrane transport
H2R00_RS08065	COG2362	D-Aminopeptidase
H2R00_RS08070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2R00_RS08075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2R00_RS08085	COG0346	lactoylglutathione lyase activity
H2R00_RS08090	COG0531	amino acid
H2R00_RS08095	COG0395	ABC-type sugar transport system, permease component
H2R00_RS08100	COG4209	transmembrane transport
H2R00_RS08105	COG1653	transport
H2R00_RS08115	COG1874	Beta-galactosidase
H2R00_RS08120	COG2755	lipolytic protein G-D-S-L family
H2R00_RS08125	COG0667	Aldo Keto reductase
H2R00_RS08130	COG3401	FG-GAP repeat protein
H2R00_RS08135	COG2755	lipolytic protein G-D-S-L family
H2R00_RS08145	COG3401	FG-GAP repeat protein
H2R00_RS08150	COG5578	integral membrane protein
H2R00_RS08160	COG2755	lipolytic protein G-D-S-L family
H2R00_RS08165	COG2207	Transcriptional regulator
H2R00_RS08170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H2R00_RS08175	COG0395	ABC-type sugar transport system, permease component
H2R00_RS08180	COG1175	transmembrane transport
H2R00_RS08185	COG1653	transport
H2R00_RS08190	COG2207	Transcriptional regulator
H2R00_RS08190	COG4753	response regulator
H2R00_RS08195	COG2972	Histidine kinase
H2R00_RS08200	COG5578	integral membrane protein
H2R00_RS08205	COG0405	Gamma-glutamyltransferase
H2R00_RS08210	COG1392	Phosphate transport regulator
H2R00_RS08215	COG0306	phosphate transporter
H2R00_RS08235	COG1063	alcohol dehydrogenase
H2R00_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS08245	COG1312	Catalyzes the dehydration of D-mannonate
H2R00_RS08250	COG1063	alcohol dehydrogenase
H2R00_RS08255	COG1802	Transcriptional regulator
H2R00_RS08285	COG3778	Protein conserved in bacteria
H2R00_RS08290	COG3299	homolog of phage Mu protein gp47
H2R00_RS08295	COG3628	GPW Gp25 family protein
H2R00_RS08305	COG4193	domain, Protein
H2R00_RS08310	COG1652	LysM domain
H2R00_RS08315	COG5280	Phage tail tape measure protein TP901
H2R00_RS08315	COG3953	SLT domain
H2R00_RS08365	COG4653	Phage capsid family
H2R00_RS08370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H2R00_RS08375	COG5518	Phage portal protein
H2R00_RS08380	COG1783	phage Terminase large subunit
H2R00_RS08385	COG3728	DNA packaging
H2R00_RS08385	COG5484	DNA packaging
H2R00_RS08390	COG1595	DNA-templated transcription, initiation
H2R00_RS08410	COG1484	DNA-dependent DNA replication
H2R00_RS08415	COG1522	sequence-specific DNA binding
H2R00_RS08430	COG1396	sequence-specific DNA binding
H2R00_RS08435	COG2856	Zn peptidase
H2R00_RS08440	COG4195	phage-related replication protein
H2R00_RS08445	COG5444	nuclease activity
H2R00_RS08465	COG1309	transcriptional regulator
H2R00_RS08470	COG2814	Major facilitator Superfamily
H2R00_RS08475	COG3584	3D domain protein
H2R00_RS08475	COG1388	LysM domain
H2R00_RS08485	COG0346	lactoylglutathione lyase activity
H2R00_RS08490	COG0697	spore germination
H2R00_RS08495	COG0583	DNA-binding transcription factor activity
H2R00_RS08500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2R00_RS08505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2R00_RS08510	COG0583	DNA-binding transcription factor activity
H2R00_RS08520	COG0110	maltose O-acetyltransferase activity
H2R00_RS08530	COG3507	Belongs to the glycosyl hydrolase 43 family
H2R00_RS08545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2R00_RS08560	COG5505	Protein of unknown function (DUF819)
H2R00_RS08565	COG0626	cystathionine gamma-synthase activity
H2R00_RS08570	COG0626	cystathionine gamma-synthase activity
H2R00_RS08590	COG2382	esterase
H2R00_RS08595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H2R00_RS08600	COG2153	protein acetylation
H2R00_RS08605	COG2246	polysaccharide biosynthetic process
H2R00_RS08610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2R00_RS08620	COG0586	Pfam SNARE associated Golgi protein
H2R00_RS08630	COG0210	DNA helicase
H2R00_RS08685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H2R00_RS08690	COG0351	phosphomethylpyrimidine kinase
H2R00_RS08695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2R00_RS08700	COG2022	thiamine diphosphate biosynthetic process
H2R00_RS08705	COG2104	thiamine diphosphate biosynthetic process
H2R00_RS08715	COG0352	thiamine-phosphate diphosphorylase activity
H2R00_RS08720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2R00_RS08725	COG0569	domain protein
H2R00_RS08725	COG0475	glutathione-regulated potassium exporter activity
H2R00_RS08730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2R00_RS08735	COG0564	pseudouridine synthase activity
H2R00_RS08740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2R00_RS08745	COG2357	RelA SpoT domain protein
H2R00_RS08755	COG4116	CYTH
H2R00_RS08760	COG0741	lytic transglycosylase activity
H2R00_RS08765	COG2346	COG2346, Truncated hemoglobins
H2R00_RS08775	COG1164	Oligoendopeptidase f
H2R00_RS08780	COG4469	Competence protein
H2R00_RS08785	COG3290	protein histidine kinase activity
H2R00_RS08790	COG4565	transcriptional regulatory protein
H2R00_RS08815	COG4862	establishment of competence for transformation
H2R00_RS08825	COG0861	Integral membrane protein TerC family
H2R00_RS08830	COG1393	Belongs to the ArsC family
H2R00_RS08835	COG0456	acetyltransferase
H2R00_RS08840	COG4608	Belongs to the ABC transporter superfamily
H2R00_RS08845	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2R00_RS08855	COG0601	transmembrane transport
H2R00_RS08860	COG4166	transmembrane transport
H2R00_RS08865	COG0180	Tryptophanyl-tRNA synthetase
H2R00_RS08875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2R00_RS08880	COG0601	transmembrane transport
H2R00_RS08890	COG4608	Belongs to the ABC transporter superfamily
H2R00_RS08895	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS08900	COG5504	Zn-dependent protease
H2R00_RS08905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2R00_RS08910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2R00_RS08925	COG1744	ABC transporter substrate-binding protein PnrA-like
H2R00_RS08935	COG2267	carboxylic ester hydrolase activity
H2R00_RS08950	COG1968	undecaprenyl-diphosphatase activity
H2R00_RS08955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2R00_RS08960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2R00_RS08965	COG0505	Belongs to the CarA family
H2R00_RS08970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2R00_RS08975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2R00_RS08980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2R00_RS08985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2R00_RS08990	COG2151	metal-sulfur cluster biosynthetic enzyme
H2R00_RS08995	COG1073	alpha beta
H2R00_RS09000	COG0561	phosphatase activity
H2R00_RS09015	COG0516	GMP reductase activity
H2R00_RS09025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS09030	COG1307	EDD domain protein, DegV family
H2R00_RS09045	COG2996	Protein conserved in bacteria
H2R00_RS09050	COG1666	GTP binding
H2R00_RS09055	COG0646	methionine synthase
H2R00_RS09055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2R00_RS09060	COG0646	methionine synthase
H2R00_RS09060	COG1410	methionine synthase
H2R00_RS09065	COG2378	regulation of single-species biofilm formation
H2R00_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS09075	COG2153	protein acetylation
H2R00_RS09100	COG0076	glutamate decarboxylase activity
H2R00_RS09110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2R00_RS09115	COG1279	arginine transmembrane transporter activity
H2R00_RS09120	COG0697	spore germination
H2R00_RS09135	COG0673	inositol 2-dehydrogenase activity
H2R00_RS09140	COG1609	Transcriptional regulator
H2R00_RS09150	COG1917	Cupin 2, conserved barrel domain protein
H2R00_RS09150	COG2207	Transcriptional regulator
H2R00_RS09155	COG0534	Mate efflux family protein
H2R00_RS09160	COG0347	Belongs to the P(II) protein family
H2R00_RS09165	COG0004	ammonium transporteR
H2R00_RS09170	COG0367	asparagine synthase
H2R00_RS09195	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2R00_RS09205	COG5337	Spore coat protein CotH
H2R00_RS09250	COG0419	ATPase involved in DNA repair
H2R00_RS09255	COG0420	3'-5' exonuclease activity
H2R00_RS09260	COG1074	ATP-dependent DNA helicase activity
H2R00_RS09265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H2R00_RS09270	COG4149	molybdate abc transporter
H2R00_RS09275	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2R00_RS09280	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H2R00_RS09285	COG0745	RESPONSE REGULATOR receiver
H2R00_RS09290	COG5002	protein histidine kinase activity
H2R00_RS09300	COG4533	DNA binding
H2R00_RS09305	COG0477	Major facilitator Superfamily
H2R00_RS09305	COG2814	Major facilitator Superfamily
H2R00_RS09310	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS09315	COG3546	catalase activity
H2R00_RS09330	COG3180	Ammonia monooxygenase
H2R00_RS09335	COG1486	melibiose metabolic process
H2R00_RS09340	COG0395	ABC-type sugar transport system, permease component
H2R00_RS09345	COG1175	transmembrane transport
H2R00_RS09350	COG1653	transport
H2R00_RS09355	COG1609	Transcriptional regulator
H2R00_RS09365	COG0457	Tetratricopeptide repeat
H2R00_RS09380	COG0549	Belongs to the carbamate kinase family
H2R00_RS09390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2R00_RS09395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2R00_RS09400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H2R00_RS09405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H2R00_RS09410	COG3257	ureidoglycine aminohydrolase activity
H2R00_RS09415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2R00_RS09420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2R00_RS09425	COG2508	Transcriptional regulator
H2R00_RS09435	COG1404	Belongs to the peptidase S8 family
H2R00_RS09440	COG0681	Belongs to the peptidase S26 family
H2R00_RS09445	COG0398	Pfam SNARE associated Golgi protein
H2R00_RS09455	COG4903	ComK protein
H2R00_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2R00_RS09470	COG0723	plastoquinol--plastocyanin reductase activity
H2R00_RS09475	COG0840	transmembrane signaling receptor activity
H2R00_RS09480	COG0406	alpha-ribazole phosphatase activity
H2R00_RS09485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS09490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS09495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H2R00_RS09500	COG0697	spore germination
H2R00_RS09510	COG0501	Belongs to the peptidase M48B family
H2R00_RS09525	COG1396	sequence-specific DNA binding
H2R00_RS09530	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS09535	COG0095	Lipoate-protein ligase
H2R00_RS09540	COG1234	tRNA 3'-trailer cleavage
H2R00_RS09550	COG1301	dicarboxylic acid transport
H2R00_RS09560	COG1363	Peptidase, m42
H2R00_RS09565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2R00_RS09570	COG1511	domain protein
H2R00_RS09575	COG1309	transcriptional regulator
H2R00_RS09590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H2R00_RS09595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2R00_RS09600	COG2329	Antibiotic biosynthesis monooxygenase
H2R00_RS09605	COG3069	C4-dicarboxylate transmembrane transporter activity
H2R00_RS09610	COG1473	amidohydrolase
H2R00_RS09620	COG4473	ABC transporter
H2R00_RS09625	COG1131	(ABC) transporter
H2R00_RS09630	COG0537	adenosine 5'-monophosphoramidase activity
H2R00_RS09635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2R00_RS09650	COG4980	gas vesicle protein
H2R00_RS09655	COG1846	Transcriptional regulator
H2R00_RS09685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2R00_RS09695	COG3481	metal-dependent phosphohydrolase, HD sub domain
H2R00_RS09700	COG4717	serine-type aminopeptidase activity
H2R00_RS09705	COG0420	3'-5' exonuclease activity
H2R00_RS09710	COG1668	transmembrane transport
H2R00_RS09715	COG4152	abc transporter atp-binding protein
H2R00_RS09735	COG0457	Tetratricopeptide repeat
H2R00_RS09740	COG1024	Enoyl-CoA hydratase
H2R00_RS09745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2R00_RS09750	COG0561	phosphatase activity
H2R00_RS09755	COG3679	Belongs to the UPF0342 family
H2R00_RS09760	COG4399	Belongs to the UPF0754 family
H2R00_RS09765	COG0189	ligase activity
H2R00_RS09770	COG0189	ligase activity
H2R00_RS09780	COG2508	Transcriptional regulator
H2R00_RS09785	COG3842	ATPase activity
H2R00_RS09810	COG0702	epimerase
H2R00_RS09815	COG1132	(ABC) transporter
H2R00_RS09820	COG1132	(ABC) transporter
H2R00_RS09825	COG0589	response to stress
H2R00_RS09850	COG2017	converts alpha-aldose to the beta-anomer
H2R00_RS09855	COG1757	Na H antiporter
H2R00_RS09865	COG0726	polysaccharide deacetylase
H2R00_RS09875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H2R00_RS09880	COG0668	transmembrane transport
H2R00_RS09890	COG0584	glycerophosphoryl diester phosphodiesterase
H2R00_RS09895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2R00_RS09900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2R00_RS09920	COG1253	flavin adenine dinucleotide binding
H2R00_RS09925	COG0789	Transcriptional regulator
H2R00_RS09930	COG1253	flavin adenine dinucleotide binding
H2R00_RS09935	COG1309	transcriptional regulator
H2R00_RS09945	COG3152	Membrane
H2R00_RS09950	COG0204	Acyl-transferase
H2R00_RS09955	COG0667	Aldo Keto reductase
H2R00_RS09960	COG0662	Cupin 2, conserved barrel domain protein
H2R00_RS09965	COG1595	DNA-templated transcription, initiation
H2R00_RS09985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2R00_RS09990	COG3708	Transcriptional regulator
H2R00_RS09990	COG2207	Transcriptional regulator
H2R00_RS10000	COG0733	neurotransmitter:sodium symporter activity
H2R00_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS10010	COG2133	pyrroloquinoline quinone binding
H2R00_RS10015	COG0372	Belongs to the citrate synthase family
H2R00_RS10020	COG0583	DNA-binding transcription factor activity
H2R00_RS10025	COG1388	LysM domain
H2R00_RS10025	COG0791	NLP P60 protein
H2R00_RS10030	COG2719	SpoVR family
H2R00_RS10035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2R00_RS10035	COG1017	nitric oxide dioxygenase activity
H2R00_RS10040	COG1959	2 iron, 2 sulfur cluster binding
H2R00_RS10055	COG0431	NADPH-dependent FMN reductase
H2R00_RS10060	COG2197	response regulator
H2R00_RS10065	COG2203	Gaf domain
H2R00_RS10065	COG4585	Histidine kinase
H2R00_RS10080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2R00_RS10085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2R00_RS10090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2R00_RS10095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2R00_RS10100	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H2R00_RS10105	COG0604	alcohol dehydrogenase
H2R00_RS10110	COG0679	Auxin Efflux Carrier
H2R00_RS10120	COG2116	formate transmembrane transporter activity
H2R00_RS10125	COG0488	(ABC) transporter
H2R00_RS10130	COG3153	acetyltransferase
H2R00_RS10130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2R00_RS10135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2R00_RS10140	COG0517	IMP dehydrogenase activity
H2R00_RS10150	COG0564	pseudouridine synthase activity
H2R00_RS10155	COG3764	Sortase (surface protein transpeptidase)
H2R00_RS10160	COG0737	Belongs to the 5'-nucleotidase family
H2R00_RS10160	COG1525	nuclease
H2R00_RS10160	COG4085	toxin activity
H2R00_RS10165	COG5002	protein histidine kinase activity
H2R00_RS10175	COG5577	PFAM Coat F domain
H2R00_RS10200	COG1823	symporter activity
H2R00_RS10205	COG1464	Belongs to the NlpA lipoprotein family
H2R00_RS10210	COG2011	ABC-type metal ion transport system permease component
H2R00_RS10215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2R00_RS10220	COG1278	Cold shock
H2R00_RS10225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2R00_RS10230	COG1131	(ABC) transporter
H2R00_RS10235	COG1131	(ABC) transporter
H2R00_RS10240	COG1725	Transcriptional regulator
H2R00_RS10255	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS10260	COG2814	Major facilitator Superfamily
H2R00_RS10265	COG1566	PFAM secretion protein HlyD family protein
H2R00_RS10270	COG2718	Belongs to the UPF0229 family
H2R00_RS10275	COG2766	serine protein kinase
H2R00_RS10280	COG1664	Polymer-forming cytoskeletal
H2R00_RS10285	COG1664	Polymer-forming cytoskeletal
H2R00_RS10290	COG0789	Transcriptional regulator
H2R00_RS10295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2R00_RS10305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2R00_RS10310	COG3382	B3 4 domain protein
H2R00_RS10320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2R00_RS10340	COG1131	(ABC) transporter
H2R00_RS10350	COG1476	TRANSCRIPTIONal
H2R00_RS10360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2R00_RS10365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2R00_RS10370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2R00_RS10375	COG1116	anion transmembrane transporter activity
H2R00_RS10380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H2R00_RS10385	COG0710	3-dehydroquinate dehydratase activity
H2R00_RS10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2R00_RS10505	COG0735	belongs to the Fur family
H2R00_RS10510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2R00_RS10515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2R00_RS10520	COG4129	membrane
H2R00_RS10535	COG0747	negative chemotaxis
H2R00_RS10540	COG4608	Belongs to the ABC transporter superfamily
H2R00_RS10545	COG0444	Belongs to the ABC transporter superfamily
H2R00_RS10550	COG1132	(ABC) transporter
H2R00_RS10555	COG3557	Belongs to the UPF0374 family
H2R00_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS10580	COG1194	a g-specific adenine glycosylase
H2R00_RS10585	COG1988	membrane-bound metal-dependent
H2R00_RS10590	COG4485	Bacterial membrane protein, YfhO
H2R00_RS10600	COG0463	Glycosyl transferase, family 2
H2R00_RS10605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2R00_RS10630	COG2137	regulation of response to DNA damage stimulus
H2R00_RS10655	COG0778	Nitroreductase
H2R00_RS10660	COG0384	phenazine biosynthesis protein PhzF
H2R00_RS10665	COG0392	lysyltransferase activity
H2R00_RS10665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H2R00_RS10675	COG1051	belongs to the nudix hydrolase family
H2R00_RS10680	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS10685	COG1653	transport
H2R00_RS10695	COG3507	Belongs to the glycosyl hydrolase 43 family
H2R00_RS10705	COG2514	catechol 2,3-dioxygenase activity
H2R00_RS10710	COG2259	Doxx family
H2R00_RS10715	COG1733	regulation of RNA biosynthetic process
H2R00_RS10730	COG1263	PTS System
H2R00_RS10730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS10735	COG1737	Transcriptional regulator
H2R00_RS10740	COG1486	melibiose metabolic process
H2R00_RS10745	COG1742	UPF0060 membrane protein
H2R00_RS10750	COG3284	Transcriptional regulator
H2R00_RS10755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2R00_RS10760	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2R00_RS10765	COG0022	dehydrogenase e1 component
H2R00_RS10770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2R00_RS10780	COG5609	conserved protein (DUF2294)
H2R00_RS10785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2R00_RS10790	COG3002	Belongs to the UPF0753 family
H2R00_RS10795	COG0288	reversible hydration of carbon dioxide
H2R00_RS10800	COG3711	transcriptional antiterminator
H2R00_RS10805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS10805	COG1263	PTS System
H2R00_RS10815	COG0477	Major facilitator Superfamily
H2R00_RS10825	COG1819	glycosyl
H2R00_RS10850	COG4637	Psort location Cytoplasmic, score
H2R00_RS10855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2R00_RS10860	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H2R00_RS10865	COG0598	Magnesium transport protein CorA
H2R00_RS10875	COG0371	Dehydrogenase
H2R00_RS10880	COG0726	polysaccharide deacetylase
H2R00_RS10890	COG0535	radical SAM domain protein
H2R00_RS10900	COG0387	Pfam Sodium calcium exchanger
H2R00_RS10910	COG0477	Major facilitator Superfamily
H2R00_RS10915	COG1295	ribonuclease BN
H2R00_RS10920	COG4980	gas vesicle protein
H2R00_RS10925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2R00_RS10930	COG1115	amino acid carrier protein
H2R00_RS10935	COG4840	Belongs to the UPF0435 family
H2R00_RS10940	COG0693	protein deglycase activity
H2R00_RS10945	COG0737	Belongs to the 5'-nucleotidase family
H2R00_RS10950	COG0778	Nitroreductase
H2R00_RS10955	COG1733	regulation of RNA biosynthetic process
H2R00_RS10970	COG0673	inositol 2-dehydrogenase activity
H2R00_RS10980	COG0457	Tetratricopeptide repeat
H2R00_RS10980	COG0463	Glycosyl transferase, family 2
H2R00_RS10985	COG1215	transferase activity, transferring glycosyl groups
H2R00_RS10995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2R00_RS11000	COG1045	serine acetyltransferase
H2R00_RS11005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2R00_RS11030	COG2188	Transcriptional regulator
H2R00_RS11035	COG0366	Alpha amylase catalytic
H2R00_RS11040	COG1263	PTS System
H2R00_RS11040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS11045	COG1115	amino acid carrier protein
H2R00_RS11055	COG1368	sulfuric ester hydrolase activity
H2R00_RS11060	COG0024	Methionine aminopeptidase
H2R00_RS11075	COG2258	MOSC domain
H2R00_RS11080	COG1254	Belongs to the acylphosphatase family
H2R00_RS11085	COG0640	Transcriptional regulator
H2R00_RS11090	COG5658	integral membrane protein
H2R00_RS11100	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H2R00_RS11110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS11140	COG0471	metal ion transport
H2R00_RS11155	COG2130	NADP-dependent
H2R00_RS11160	COG0513	Belongs to the DEAD box helicase family
H2R00_RS11165	COG0488	(ABC) transporter
H2R00_RS11170	COG2814	Major facilitator Superfamily
H2R00_RS11175	COG0789	Transcriptional regulator
H2R00_RS11185	COG2124	cytochrome p450
H2R00_RS11190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H2R00_RS11195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H2R00_RS11200	COG0156	8-amino-7-oxononanoate synthase activity
H2R00_RS11205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2R00_RS11210	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
H2R00_RS11215	COG0523	cobalamin synthesis protein
H2R00_RS11230	COG1469	GTP cyclohydrolase I activity
H2R00_RS11240	COG0583	DNA-binding transcription factor activity
H2R00_RS11245	COG0488	(ABC) transporter
H2R00_RS11250	COG0471	metal ion transport
H2R00_RS11265	COG0109	protoheme IX farnesyltransferase activity
H2R00_RS11270	COG0840	transmembrane signaling receptor activity
H2R00_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS11290	COG0217	transcriptional regulatory protein
H2R00_RS11295	COG2226	methyltransferase
H2R00_RS11305	COG0457	Tetratricopeptide repeat
H2R00_RS11310	COG3711	transcriptional antiterminator
H2R00_RS11315	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS11320	COG2190	(PTS) system
H2R00_RS11320	COG1263	PTS System
H2R00_RS11320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS11330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2R00_RS11335	COG1597	lipid kinase activity
H2R00_RS11340	COG1957	nucleoside hydrolase
H2R00_RS11345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS11355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2R00_RS11360	COG1309	transcriptional regulator
H2R00_RS11365	COG4124	Belongs to the glycosyl hydrolase 26 family
H2R00_RS11380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2R00_RS11385	COG0154	amidase activity
H2R00_RS11390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2R00_RS11395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS11400	COG1285	pathogenesis
H2R00_RS11405	COG0363	glucosamine-6-phosphate deaminase activity
H2R00_RS11410	COG3457	Alanine racemase
H2R00_RS11415	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H2R00_RS11420	COG0626	cystathionine gamma-synthase activity
H2R00_RS11425	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H2R00_RS11445	COG2188	Transcriptional regulator
H2R00_RS11450	COG4851	CamS sex pheromone cAM373 precursor
H2R00_RS11455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2R00_RS11460	COG0210	DNA helicase
H2R00_RS11465	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H2R00_RS11470	COG4496	protein, YerC YecD
H2R00_RS11475	COG1470	cell adhesion involved in biofilm formation
H2R00_RS11480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2R00_RS11500	COG2124	cytochrome p450
H2R00_RS11505	COG1309	transcriptional regulator
H2R00_RS11510	COG0151	Belongs to the GarS family
H2R00_RS11515	COG0138	bifunctional purine biosynthesis protein purh
H2R00_RS11520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2R00_RS11525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H2R00_RS11530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H2R00_RS11535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2R00_RS11540	COG0047	phosphoribosylformylglycinamidine synthase activity
H2R00_RS11545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2R00_RS11550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2R00_RS11555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2R00_RS11560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2R00_RS11565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H2R00_RS11575	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H2R00_RS11590	COG2252	PERMEase
H2R00_RS11595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2R00_RS11595	COG0519	Catalyzes the synthesis of GMP from XMP
H2R00_RS11600	COG1305	Transglutaminase-like
H2R00_RS11605	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H2R00_RS11610	COG0714	Associated with various cellular activities
H2R00_RS11615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H2R00_RS11635	COG2132	Multicopper oxidase
H2R00_RS11645	COG0702	epimerase
H2R00_RS11665	COG0823	Involved in the tonB-independent uptake of proteins
H2R00_RS11670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H2R00_RS11685	COG1846	Transcriptional regulator
H2R00_RS11690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2R00_RS11695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2R00_RS11700	COG0366	Alpha amylase catalytic
H2R00_RS11705	COG1554	hydrolase, family 65, central catalytic
H2R00_RS11710	COG5521	maltodextrose utilization protein MalA
H2R00_RS11715	COG3833	ABC-type maltose transport systems, permease component
H2R00_RS11720	COG1175	transmembrane transport
H2R00_RS11725	COG2182	Extracellular solute-binding protein
H2R00_RS11730	COG0366	Alpha amylase catalytic
H2R00_RS11735	COG1609	Transcriptional regulator
H2R00_RS11745	COG0726	polysaccharide deacetylase
H2R00_RS11765	COG0772	Belongs to the SEDS family
H2R00_RS11770	COG0772	Belongs to the SEDS family
H2R00_RS11775	COG3339	Conserved Protein
H2R00_RS11780	COG1280	lysine exporter protein (LysE YggA)
H2R00_RS11785	COG1378	Sugar-specific transcriptional regulator TrmB
H2R00_RS11795	COG4260	virion core protein, lumpy skin disease virus
H2R00_RS11800	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2R00_RS11805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2R00_RS11810	COG1842	Phage shock protein A
H2R00_RS11815	COG2814	Major facilitator Superfamily
H2R00_RS11820	COG2272	Belongs to the type-B carboxylesterase lipase family
H2R00_RS11825	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H2R00_RS11830	COG3189	MarR family transcriptional regulator
H2R00_RS11840	COG3848	Pyruvate phosphate dikinase
H2R00_RS11840	COG0574	Belongs to the PEP-utilizing enzyme family
H2R00_RS11845	COG1309	transcriptional regulator
H2R00_RS11855	COG2135	peptidase activity
H2R00_RS11875	COG2720	vancomycin resistance protein
H2R00_RS11895	COG0459	protein refolding
H2R00_RS11900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2R00_RS11905	COG1266	CAAX protease self-immunity
H2R00_RS11915	COG0805	protein transport
H2R00_RS11920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2R00_RS11925	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H2R00_RS11930	COG0315	cyclic pyranopterin monophosphate synthase activity
H2R00_RS11935	COG0488	(ABC) transporter
H2R00_RS11940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2R00_RS11945	COG0456	acetyltransferase
H2R00_RS11950	COG1214	PFAM Peptidase M22, glycoprotease
H2R00_RS11955	COG0802	atpase or kinase
H2R00_RS11960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2R00_RS12000	COG2814	Major facilitator Superfamily
H2R00_RS12005	COG3764	Sortase (surface protein transpeptidase)
H2R00_RS12015	COG3279	Response regulator of the LytR AlgR family
H2R00_RS12020	COG2972	Histidine kinase
H2R00_RS12020	COG0745	RESPONSE REGULATOR receiver
H2R00_RS12025	COG1979	alcohol dehydrogenase
H2R00_RS12030	COG2814	Major facilitator Superfamily
H2R00_RS12035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H2R00_RS12035	COG2755	lipolytic protein G-D-S-L family
H2R00_RS12045	COG1595	DNA-templated transcription, initiation
H2R00_RS12060	COG1113	amino acid transport
H2R00_RS12065	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H2R00_RS12075	COG1733	regulation of RNA biosynthetic process
H2R00_RS12080	COG3545	Serine hydrolase
H2R00_RS12105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS12110	COG2808	Putative FMN-binding domain
H2R00_RS12115	COG0456	acetyltransferase
H2R00_RS12120	COG1846	Transcriptional regulator
H2R00_RS12135	COG1329	Transcriptional regulator
H2R00_RS12140	COG1278	Cold shock
H2R00_RS12145	COG3239	Fatty acid desaturase
H2R00_RS12185	COG3091	SprT-like family
H2R00_RS12195	COG1033	growth of symbiont in host cell
H2R00_RS12195	COG2409	Drug exporters of the RND superfamily
H2R00_RS12200	COG1309	transcriptional regulator
H2R00_RS12205	COG2183	response to ionizing radiation
H2R00_RS12210	COG2208	phosphoserine phosphatase activity
H2R00_RS12215	COG1191	sigma factor activity
H2R00_RS12230	COG2208	phosphoserine phosphatase activity
H2R00_RS12235	COG2172	sigma factor antagonist activity
H2R00_RS12240	COG1366	Belongs to the anti-sigma-factor antagonist family
H2R00_RS12245	COG1366	Belongs to the anti-sigma-factor antagonist family
H2R00_RS12250	COG2337	Toxic component of a toxin-antitoxin (TA) module
H2R00_RS12255	COG0864	Transcriptional regulator
H2R00_RS12260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2R00_RS12265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2R00_RS12270	COG0705	Rhomboid family
H2R00_RS12275	COG3428	Bacterial PH domain
H2R00_RS12280	COG3402	PFAM membrane-flanked domain
H2R00_RS12285	COG0513	Belongs to the DEAD box helicase family
H2R00_RS12295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2R00_RS12300	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2R00_RS12305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS12320	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS12330	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2R00_RS12335	COG1131	(ABC) transporter
H2R00_RS12340	COG1301	dicarboxylic acid transport
H2R00_RS12345	COG0628	permease
H2R00_RS12355	COG0662	Cupin 2, conserved barrel domain protein
H2R00_RS12365	COG2217	Heavy metal translocating P-type atpase
H2R00_RS12370	COG4876	unkown
H2R00_RS12375	COG1819	glycosyl
H2R00_RS12380	COG1027	Aspartate ammonia-lyase
H2R00_RS12385	COG2261	transglycosylase associated protein
H2R00_RS12390	COG1914	H( )-stimulated, divalent metal cation uptake system
H2R00_RS12395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS12405	COG3397	chitin binding
H2R00_RS12410	COG0028	Belongs to the TPP enzyme family
H2R00_RS12415	COG0551	DNA topoisomerase type I activity
H2R00_RS12415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2R00_RS12420	COG1522	sequence-specific DNA binding
H2R00_RS12430	COG2814	Major facilitator Superfamily
H2R00_RS12445	COG3871	stress protein (general stress protein 26)
H2R00_RS12455	COG1917	Cupin 2, conserved barrel domain protein
H2R00_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS12465	COG3711	transcriptional antiterminator
H2R00_RS12470	COG0246	Mannitol dehydrogenase
H2R00_RS12475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS12480	COG2213	PTS system mannitol-specific
H2R00_RS12485	COG2755	lipolytic protein G-D-S-L family
H2R00_RS12490	COG1414	Transcriptional regulator
H2R00_RS12495	COG1984	allophanate hydrolase subunit 2
H2R00_RS12500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2R00_RS12505	COG4336	lyase activity
H2R00_RS12510	COG1914	H( )-stimulated, divalent metal cation uptake system
H2R00_RS12515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H2R00_RS12520	COG0561	phosphatase activity
H2R00_RS12525	COG3958	Transketolase
H2R00_RS12530	COG3959	Transketolase, thiamine diphosphate binding domain
H2R00_RS12545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS12555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2R00_RS12560	COG0471	metal ion transport
H2R00_RS12565	COG1802	Transcriptional regulator
H2R00_RS12570	COG1587	Uroporphyrinogen-III synthase
H2R00_RS12570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2R00_RS12575	COG2146	nitrite reductase [NAD(P)H] activity
H2R00_RS12580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2R00_RS12585	COG0243	molybdopterin cofactor binding
H2R00_RS12590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2R00_RS12595	COG1349	DNA-binding transcription factor activity
H2R00_RS12600	COG2372	response to copper ion
H2R00_RS12600	COG1276	copper resistance
H2R00_RS12605	COG4549	nuclear export factor GLE1
H2R00_RS12615	COG0697	spore germination
H2R00_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS12625	COG0531	amino acid
H2R00_RS12630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2R00_RS12635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2R00_RS12640	COG0640	Transcriptional regulator
H2R00_RS12645	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2R00_RS12650	COG0778	Nitroreductase
H2R00_RS12660	COG1309	transcriptional regulator
H2R00_RS12665	COG2814	Major facilitator Superfamily
H2R00_RS12670	COG4607	ABC-type enterochelin transport system periplasmic component
H2R00_RS12675	COG4604	ABC transporter, ATP-binding protein
H2R00_RS12680	COG4605	iron ion homeostasis
H2R00_RS12685	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS12690	COG0527	aspartate kinase activity
H2R00_RS12695	COG0840	transmembrane signaling receptor activity
H2R00_RS12700	COG5002	protein histidine kinase activity
H2R00_RS12700	COG3850	Histidine kinase
H2R00_RS12705	COG0745	RESPONSE REGULATOR receiver
H2R00_RS12710	COG0577	efflux transmembrane transporter activity
H2R00_RS12715	COG1136	(ABC) transporter
H2R00_RS12720	COG0789	Transcriptional regulator
H2R00_RS12725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2R00_RS12735	COG0697	spore germination
H2R00_RS12745	COG5434	Belongs to the glycosyl hydrolase 28 family
H2R00_RS12750	COG3104	oligopeptide transport
H2R00_RS12755	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
H2R00_RS12760	COG1874	Beta-galactosidase
H2R00_RS12765	COG1846	Transcriptional regulator
H2R00_RS12765	COG0456	acetyltransferase
H2R00_RS12770	COG2271	Major facilitator Superfamily
H2R00_RS12785	COG4214	carbohydrate transport
H2R00_RS12795	COG4213	ABC transporter substrate-binding protein
H2R00_RS12800	COG4753	response regulator
H2R00_RS12800	COG2207	Transcriptional regulator
H2R00_RS12805	COG2972	Histidine kinase
H2R00_RS12875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2R00_RS12880	COG0163	prenyltransferase activity
H2R00_RS12885	COG0583	DNA-binding transcription factor activity
H2R00_RS12890	COG0010	Belongs to the arginase family
H2R00_RS12895	COG0833	amino acid
H2R00_RS12900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2R00_RS12905	COG3829	transcription factor binding
H2R00_RS12910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2R00_RS12915	COG0765	amino acid transport
H2R00_RS12920	COG1126	abc transporter atp-binding protein
H2R00_RS12925	COG0840	transmembrane signaling receptor activity
H2R00_RS12950	COG1131	(ABC) transporter
H2R00_RS12960	COG2364	Membrane
H2R00_RS12970	COG2819	hydrolase of the alpha beta superfamily
H2R00_RS12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2R00_RS12985	COG0697	spore germination
H2R00_RS12990	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2R00_RS12995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS13000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS13005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS13010	COG1177	transmembrane transport
H2R00_RS13015	COG1176	ABC-type spermidine putrescine transport system, permease component I
H2R00_RS13040	COG5444	nuclease activity
H2R00_RS13045	COG3290	protein histidine kinase activity
H2R00_RS13045	COG0840	transmembrane signaling receptor activity
H2R00_RS13060	COG3209	COG3209 Rhs family protein
H2R00_RS13070	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS13080	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS13085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2R00_RS13090	COG0765	amino acid transport
H2R00_RS13110	COG3458	cephalosporin-C deacetylase activity
H2R00_RS13115	COG0701	Predicted permease
H2R00_RS13120	COG3689	TIGRFAM TIGR03943 family protein
H2R00_RS13125	COG2508	Transcriptional regulator
H2R00_RS13130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS13135	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS13140	COG0506	proline dehydrogenase activity
H2R00_RS13145	COG3541	Predicted nucleotidyltransferase
H2R00_RS13150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2R00_RS13155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2R00_RS13160	COG1113	amino acid transport
H2R00_RS13165	COG1280	lysine exporter protein (LysE YggA)
H2R00_RS13170	COG1620	l-lactate permease
H2R00_RS13175	COG0039	L-malate dehydrogenase activity
H2R00_RS13180	COG2223	nitrite transmembrane transporter activity
H2R00_RS13185	COG0789	Transcriptional regulator
H2R00_RS13195	COG0785	Cytochrome C biogenesis protein
H2R00_RS13200	COG3853	Toxic anion resistance protein (TelA)
H2R00_RS13220	COG0861	Integral membrane protein TerC family
H2R00_RS13225	COG2310	stress, protein
H2R00_RS13230	COG2310	stress, protein
H2R00_RS13235	COG2310	stress, protein
H2R00_RS13255	COG1309	transcriptional regulator
H2R00_RS13260	COG1131	(ABC) transporter
H2R00_RS13270	COG3883	PFAM NLP P60 protein
H2R00_RS13270	COG0791	NLP P60 protein
H2R00_RS13275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2R00_RS13280	COG3773	Cell wall hydrolase
H2R00_RS13290	COG1595	DNA-templated transcription, initiation
H2R00_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS13305	COG3591	Belongs to the peptidase S1B family
H2R00_RS13320	COG3394	polysaccharide catabolic process
H2R00_RS13325	COG2188	Transcriptional regulator
H2R00_RS13330	COG1486	melibiose metabolic process
H2R00_RS13335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS13340	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2R00_RS13345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS13350	COG0277	FAD linked oxidase domain protein
H2R00_RS13355	COG0247	lactate metabolic process
H2R00_RS13365	COG2261	transglycosylase associated protein
H2R00_RS13370	COG1164	Oligoendopeptidase f
H2R00_RS13380	COG0456	acetyltransferase
H2R00_RS13385	COG0252	asparaginase activity
H2R00_RS13395	COG1288	antiporter activity
H2R00_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS13415	COG1942	4-Oxalocrotonate Tautomerase
H2R00_RS13420	COG0583	DNA-binding transcription factor activity
H2R00_RS13445	COG1131	(ABC) transporter
H2R00_RS13450	COG1405	negative regulation of cell septum assembly
H2R00_RS13450	COG3012	SEC-C Motif Domain Protein
H2R00_RS13455	COG1714	RDD family
H2R00_RS13465	COG0693	protein deglycase activity
H2R00_RS13505	COG0789	Transcriptional regulator
H2R00_RS13525	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS13530	COG1846	Transcriptional regulator
H2R00_RS13535	COG3173	Aminoglycoside phosphotransferase
H2R00_RS13560	COG1131	(ABC) transporter
H2R00_RS13565	COG2205	protein histidine kinase activity
H2R00_RS13570	COG0745	RESPONSE REGULATOR receiver
H2R00_RS13590	COG2721	sulfolactate sulfo-lyase activity
H2R00_RS13595	COG2186	Transcriptional regulator
H2R00_RS13600	COG4948	Mandelate Racemase Muconate Lactonizing
H2R00_RS13605	COG2271	Major facilitator Superfamily
H2R00_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS13615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2R00_RS13620	COG0805	protein transport
H2R00_RS13625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2R00_RS13630	COG3540	Alkaline phosphatase
H2R00_RS13655	COG0784	Response regulator, receiver
H2R00_RS13660	COG4191	Histidine kinase
H2R00_RS13665	COG2066	Belongs to the glutaminase family
H2R00_RS13670	COG1115	amino acid carrier protein
H2R00_RS13675	COG2205	protein histidine kinase activity
H2R00_RS13695	COG2323	membrane
H2R00_RS13700	COG0789	Transcriptional regulator
H2R00_RS13705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS13705	COG1263	PTS System
H2R00_RS13705	COG2190	(PTS) system
H2R00_RS13715	COG2040	homocysteine
H2R00_RS13720	COG0833	amino acid
H2R00_RS13730	COG4257	antibiotic catabolic process
H2R00_RS13750	COG0371	Dehydrogenase
H2R00_RS13760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2R00_RS13780	COG1917	Cupin 2, conserved barrel domain protein
H2R00_RS13780	COG2207	Transcriptional regulator
H2R00_RS13785	COG0697	spore germination
H2R00_RS13805	COG4682	membrane
H2R00_RS13810	COG1283	sodium-dependent phosphate transmembrane transporter activity
H2R00_RS13835	COG0477	Major facilitator Superfamily
H2R00_RS13840	COG4122	O-methyltransferase activity
H2R00_RS13850	COG0596	Alpha beta hydrolase
H2R00_RS13855	COG1733	regulation of RNA biosynthetic process
H2R00_RS13865	COG1331	Highly conserved protein containing a thioredoxin domain
H2R00_RS13890	COG2211	Major facilitator Superfamily
H2R00_RS13910	COG1011	Hydrolase
H2R00_RS13935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2R00_RS13940	COG1132	(ABC) transporter
H2R00_RS13950	COG2814	Major facilitator Superfamily
H2R00_RS13955	COG0640	Transcriptional regulator
H2R00_RS13960	COG1725	Transcriptional regulator
H2R00_RS13990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2R00_RS13995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2R00_RS14000	COG4856	YbbR-like protein
H2R00_RS14005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H2R00_RS14010	COG5662	AntiSigma factor
H2R00_RS14015	COG1595	DNA-templated transcription, initiation
H2R00_RS14050	COG1683	Conserved Protein
H2R00_RS14055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H2R00_RS14060	COG1737	Transcriptional regulator
H2R00_RS14065	COG1263	PTS System
H2R00_RS14065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS14070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2R00_RS14075	COG1472	Belongs to the glycosyl hydrolase 3 family
H2R00_RS14080	COG3876	Protein conserved in bacteria
H2R00_RS14095	COG0385	Bile acid
H2R00_RS14105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2R00_RS14140	COG0726	polysaccharide deacetylase
H2R00_RS14145	COG2194	sulfuric ester hydrolase activity
H2R00_RS14155	COG0489	protein tyrosine kinase activity
H2R00_RS14160	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2R00_RS14170	COG2318	DinB family
H2R00_RS14175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2R00_RS14180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2R00_RS14185	COG0101	tRNA pseudouridine synthase activity
H2R00_RS14190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2R00_RS14195	COG1122	ATPase activity
H2R00_RS14200	COG1122	ATPase activity
H2R00_RS14205	COG0203	ribosomal protein L17
H2R00_RS14210	COG0202	RNA polymerase activity
H2R00_RS14215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2R00_RS14220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2R00_RS14225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2R00_RS14230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2R00_RS14235	COG2163	COG2163 Ribosomal protein L14E L6E L27E
H2R00_RS14240	COG0024	Methionine aminopeptidase
H2R00_RS14245	COG0563	adenylate kinase activity
H2R00_RS14250	COG0201	protein transport
H2R00_RS14255	COG0200	Binds to the 23S rRNA
H2R00_RS14260	COG1841	ribosomal large subunit assembly
H2R00_RS14265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2R00_RS14270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H2R00_RS14275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2R00_RS14280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2R00_RS14285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2R00_RS14290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2R00_RS14295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H2R00_RS14300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2R00_RS14305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2R00_RS14310	COG0255	Belongs to the universal ribosomal protein uL29 family
H2R00_RS14315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2R00_RS14320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H2R00_RS14325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2R00_RS14330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2R00_RS14335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2R00_RS14340	COG0089	rRNA binding
H2R00_RS14345	COG0088	Forms part of the polypeptide exit tunnel
H2R00_RS14350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2R00_RS14360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2R00_RS14365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2R00_RS14370	COG0049	tRNA binding
H2R00_RS14375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2R00_RS14380	COG1358	cellular component organization or biogenesis
H2R00_RS14385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2R00_RS14390	COG0085	RNA polymerase activity
H2R00_RS14395	COG2813	Specifically methylates the guanine in position
H2R00_RS14400	COG0222	ribosome binding
H2R00_RS14405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2R00_RS14410	COG0081	regulation of translation
H2R00_RS14415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2R00_RS14420	COG0250	Participates in transcription elongation, termination and antitermination
H2R00_RS14430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2R00_RS14440	COG3688	RNA-binding protein containing a PIN domain
H2R00_RS14445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2R00_RS14450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H2R00_RS14455	COG0215	cysteine-tRNA ligase activity
H2R00_RS14460	COG1045	serine acetyltransferase
H2R00_RS14465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2R00_RS14470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H2R00_RS14475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2R00_RS14480	COG4956	integral membrane protein (PIN domain superfamily)
H2R00_RS14485	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H2R00_RS14490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H2R00_RS14495	COG0542	response to heat
H2R00_RS14500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H2R00_RS14505	COG3880	PFAM UvrB UvrC protein
H2R00_RS14510	COG4463	regulation of RNA biosynthetic process
H2R00_RS14590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2R00_RS14595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2R00_RS14600	COG1396	sequence-specific DNA binding
H2R00_RS14605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2R00_RS14610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2R00_RS14615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2R00_RS14620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2R00_RS14625	COG0512	Glutamine amidotransferase of anthranilate synthase
H2R00_RS14630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2R00_RS14635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2R00_RS14640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2R00_RS14645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2R00_RS14650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H2R00_RS14655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2R00_RS14665	COG0037	tRNA processing
H2R00_RS14670	COG0515	serine threonine protein kinase
H2R00_RS14675	COG2304	oxidoreductase activity
H2R00_RS14680	COG2208	phosphoserine phosphatase activity
H2R00_RS14695	COG1098	S1 RNA binding domain
H2R00_RS14700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2R00_RS14715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2R00_RS14720	COG3956	TIGRFAM MazG family protein
H2R00_RS14725	COG2244	polysaccharide biosynthetic process
H2R00_RS14730	COG2002	toxin-antitoxin pair type II binding
H2R00_RS14735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2R00_RS14745	COG0193	aminoacyl-tRNA hydrolase activity
H2R00_RS14750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2R00_RS14755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2R00_RS14760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2R00_RS14765	COG2088	sporulation resulting in formation of a cellular spore
H2R00_RS14770	COG0251	oxidation-reduction process
H2R00_RS14775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2R00_RS14780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2R00_RS14790	COG4466	Protein conserved in bacteria
H2R00_RS14800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2R00_RS14805	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H2R00_RS14810	COG3584	3D domain protein
H2R00_RS14810	COG3583	domain protein
H2R00_RS14815	COG0084	hydrolase, TatD family'
H2R00_RS14820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2R00_RS14820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2R00_RS14825	COG2002	toxin-antitoxin pair type II binding
H2R00_RS14830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H2R00_RS14835	COG2827	Endonuclease containing a URI domain
H2R00_RS14840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H2R00_RS14845	COG4467	Involved in initiation control of chromosome replication
H2R00_RS14850	COG1774	PSP1 C-terminal conserved region
H2R00_RS14855	COG0470	DNA polymerase III
H2R00_RS14860	COG1728	Protein conserved in bacteria
H2R00_RS14865	COG3870	Protein conserved in bacteria
H2R00_RS14870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2R00_RS14875	COG1982	Orn Lys Arg decarboxylase major
H2R00_RS14880	COG3853	Toxic anion resistance protein (TelA)
H2R00_RS14885	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H2R00_RS14930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2R00_RS14935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H2R00_RS14940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2R00_RS14950	COG0590	tRNA wobble adenosine to inosine editing
H2R00_RS14955	COG1335	isochorismatase
H2R00_RS14960	COG3858	chitin binding
H2R00_RS14960	COG1388	LysM domain
H2R00_RS14965	COG1428	Deoxynucleoside kinase
H2R00_RS14970	COG1428	Deoxynucleoside kinase
H2R00_RS14985	COG3835	regulator
H2R00_RS14990	COG2610	gluconate transmembrane transporter activity
H2R00_RS14995	COG1929	Belongs to the glycerate kinase type-1 family
H2R00_RS15000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2R00_RS15005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H2R00_RS15010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H2R00_RS15015	COG1686	Belongs to the peptidase S11 family
H2R00_RS15020	COG0516	GMP reductase activity
H2R00_RS15020	COG0517	IMP dehydrogenase activity
H2R00_RS15055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2R00_RS15060	COG0187	DNA topoisomerase II activity
H2R00_RS15070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2R00_RS15075	COG2501	S4 domain
H2R00_RS15080	COG0592	DNA-directed DNA polymerase activity
H2R00_RS15085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2R00_RS15095	COG0594	ribonuclease P activity
H2R00_RS15100	COG0706	membrane insertase activity
H2R00_RS15105	COG1847	R3H domain protein
H2R00_RS15110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H2R00_RS15115	COG0445	tRNA wobble uridine modification
H2R00_RS15120	COG0357	Ribosomal RNA small subunit methyltransferase G
H2R00_RS15125	COG1475	DNA binding
H2R00_RS15130	COG1595	DNA-templated transcription, initiation
H2R00_RS15135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2R00_RS15140	COG1192	Involved in chromosome partitioning
H2R00_RS15145	COG1475	DNA binding
H2R00_RS15155	COG3949	Membrane
H2R00_RS15160	COG4481	Protein conserved in bacteria
H2R00_RS15165	COG0012	GTP binding
H2R00_RS15170	COG0360	Binds together with S18 to 16S ribosomal RNA
H2R00_RS15175	COG0629	single-stranded DNA binding
H2R00_RS15180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H2R00_RS15185	COG2271	Major facilitator Superfamily
H2R00_RS15190	COG0659	secondary active sulfate transmembrane transporter activity
H2R00_RS15195	COG0589	response to stress
H2R00_RS15200	COG5577	PFAM Coat F domain
H2R00_RS15210	COG4241	membrane
H2R00_RS15215	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H2R00_RS15220	COG0359	binds to the 23S rRNA
H2R00_RS15225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS15225	COG1263	PTS System
H2R00_RS15230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H2R00_RS15235	COG2188	Transcriptional regulator
H2R00_RS15240	COG0363	glucosamine-6-phosphate deaminase activity
H2R00_RS15245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H2R00_RS15250	COG2807	transmembrane transport
H2R00_RS15255	COG3093	addiction module antidote protein HigA
H2R00_RS15270	COG0305	Participates in initiation and elongation during chromosome replication
H2R00_RS15280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2R00_RS15310	COG0745	RESPONSE REGULATOR receiver
H2R00_RS15315	COG5002	protein histidine kinase activity
H2R00_RS15320	COG4863	YycH protein
H2R00_RS15325	COG4853	Protein conserved in bacteria
H2R00_RS15330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H2R00_RS15335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2R00_RS15350	COG0456	acetyltransferase
H2R00_RS15365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H2R00_RS15395	COG2197	response regulator
H2R00_RS15400	COG4585	Histidine kinase
H2R00_RS15405	COG0842	Transport permease protein
H2R00_RS15410	COG1131	(ABC) transporter
H2R00_RS15425	COG3634	alkyl hydroperoxide reductase activity
H2R00_RS15430	COG0450	alkyl hydroperoxide reductase
H2R00_RS15435	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS15435	COG1454	alcohol dehydrogenase
H2R00_RS15460	COG1940	carbohydrate kinase activity
H2R00_RS15465	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H2R00_RS15470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2R00_RS15480	COG1609	Transcriptional regulator
H2R00_RS15485	COG2182	Extracellular solute-binding protein
H2R00_RS15490	COG1175	transmembrane transport
H2R00_RS15495	COG3833	ABC-type maltose transport systems, permease component
H2R00_RS15500	COG1874	Beta-galactosidase
H2R00_RS15505	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H2R00_RS15510	COG0686	Belongs to the AlaDH PNT family
H2R00_RS15515	COG1115	amino acid carrier protein
H2R00_RS15520	COG5278	phosphoserine phosphatase activity
H2R00_RS15520	COG0840	transmembrane signaling receptor activity
H2R00_RS15530	COG0745	RESPONSE REGULATOR receiver
H2R00_RS15535	COG2205	protein histidine kinase activity
H2R00_RS15540	COG1136	(ABC) transporter
H2R00_RS15545	COG0577	efflux transmembrane transporter activity
H2R00_RS15550	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H2R00_RS15565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS15585	COG0561	phosphatase activity
H2R00_RS15590	COG0488	(ABC) transporter
H2R00_RS15595	COG0326	Molecular chaperone. Has ATPase activity
H2R00_RS15600	COG2271	Major facilitator Superfamily
H2R00_RS15605	COG0584	glycerophosphoryl diester phosphodiesterase
H2R00_RS15610	COG0667	Aldo Keto reductase
H2R00_RS15615	COG1349	DNA-binding transcription factor activity
H2R00_RS15620	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS15625	COG3718	enzyme involved in inositol metabolism
H2R00_RS15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2R00_RS15635	COG3962	Belongs to the TPP enzyme family
H2R00_RS15640	COG1082	Xylose isomerase domain protein TIM barrel
H2R00_RS15645	COG2814	Major facilitator Superfamily
H2R00_RS15650	COG0673	inositol 2-dehydrogenase activity
H2R00_RS15655	COG1082	Xylose isomerase domain protein TIM barrel
H2R00_RS15660	COG1082	Xylose isomerase domain protein TIM barrel
H2R00_RS15665	COG0191	fructose-bisphosphate aldolase activity
H2R00_RS15690	COG3977	Valine--pyruvate aminotransferase
H2R00_RS15700	COG1215	transferase activity, transferring glycosyl groups
H2R00_RS15705	COG5298	Protein conserved in bacteria
H2R00_RS15710	COG3706	GGDEF domain
H2R00_RS15715	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2R00_RS15725	COG2390	Transcriptional regulator
H2R00_RS15730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2R00_RS15735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2R00_RS15740	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H2R00_RS15770	COG0513	Belongs to the DEAD box helicase family
H2R00_RS15775	COG3507	Belongs to the glycosyl hydrolase 43 family
H2R00_RS15795	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H2R00_RS15805	COG1263	PTS System
H2R00_RS15805	COG2190	(PTS) system
H2R00_RS15805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS15810	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS15815	COG0745	RESPONSE REGULATOR receiver
H2R00_RS15820	COG2205	protein histidine kinase activity
H2R00_RS15825	COG1136	(ABC) transporter
H2R00_RS15830	COG0577	efflux transmembrane transporter activity
H2R00_RS15890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H2R00_RS15900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2R00_RS15905	COG2224	Isocitrate lyase
H2R00_RS15915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2R00_RS15920	COG4721	ABC-type cobalt transport system, permease component
H2R00_RS15925	COG1122	ATPase activity
H2R00_RS15930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2R00_RS15935	COG3711	transcriptional antiterminator
H2R00_RS15940	COG1263	PTS System
H2R00_RS15940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS15940	COG2190	(PTS) system
H2R00_RS15945	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS15955	COG0753	catalase activity
H2R00_RS15955	COG0693	protein deglycase activity
H2R00_RS15965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2R00_RS15995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2R00_RS16000	COG0463	Glycosyl transferase, family 2
H2R00_RS16005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H2R00_RS16010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2R00_RS16025	COG1609	Transcriptional regulator
H2R00_RS16035	COG1175	transmembrane transport
H2R00_RS16040	COG0395	ABC-type sugar transport system, permease component
H2R00_RS16045	COG2223	nitrite transmembrane transporter activity
H2R00_RS16060	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2R00_RS16070	COG1595	DNA-templated transcription, initiation
H2R00_RS16080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS16085	COG2723	6-phospho-beta-galactosidase activity
H2R00_RS16095	COG0549	Belongs to the carbamate kinase family
H2R00_RS16105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2R00_RS16110	COG2235	arginine
H2R00_RS16120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS16130	COG1368	sulfuric ester hydrolase activity
H2R00_RS16145	COG0584	glycerophosphoryl diester phosphodiesterase
H2R00_RS16150	COG3493	citrate carrier protein
H2R00_RS16155	COG1215	transferase activity, transferring glycosyl groups
H2R00_RS16165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2R00_RS16170	COG0726	polysaccharide deacetylase
H2R00_RS16185	COG5294	Protein conserved in bacteria
H2R00_RS16190	COG0577	efflux transmembrane transporter activity
H2R00_RS16195	COG1136	(ABC) transporter
H2R00_RS16200	COG2205	protein histidine kinase activity
H2R00_RS16205	COG0745	RESPONSE REGULATOR receiver
H2R00_RS16210	COG2706	6-phosphogluconolactonase activity
H2R00_RS16215	COG1396	sequence-specific DNA binding
H2R00_RS16220	COG0252	asparaginase activity
H2R00_RS16225	COG1027	Aspartate ammonia-lyase
H2R00_RS16230	COG1757	Na H antiporter
H2R00_RS16235	COG0281	malic enzyme
H2R00_RS16245	COG2116	formate transmembrane transporter activity
H2R00_RS16255	COG1271	oxidase subunit
H2R00_RS16260	COG1294	oxidase, subunit
H2R00_RS16265	COG4988	ABC transporter
H2R00_RS16270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H2R00_RS16275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2R00_RS16290	COG0735	belongs to the Fur family
H2R00_RS16295	COG0753	catalase activity
H2R00_RS16300	COG0753	catalase activity
H2R00_RS16310	COG2814	Major facilitator Superfamily
H2R00_RS16315	COG1595	DNA-templated transcription, initiation
H2R00_RS16330	COG1131	(ABC) transporter
H2R00_RS16335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2R00_RS16340	COG2814	Major facilitator Superfamily
H2R00_RS16355	COG2755	lipolytic protein G-D-S-L family
H2R00_RS16360	COG1132	(ABC) transporter
H2R00_RS16375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H2R00_RS16380	COG2079	MmgE PrpD family protein
H2R00_RS16385	COG0372	Belongs to the citrate synthase family
H2R00_RS16395	COG2094	Belongs to the DNA glycosylase MPG family
H2R00_RS16400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS16400	COG3711	transcriptional antiterminator
H2R00_RS16405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS16410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2R00_RS16415	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2R00_RS16420	COG1486	melibiose metabolic process
H2R00_RS16425	COG2814	Major facilitator Superfamily
H2R00_RS16430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2R00_RS16435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H2R00_RS16440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2R00_RS16445	COG1696	Membrane protein involved in D-alanine export
H2R00_RS16450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS16465	COG2357	RelA SpoT domain protein
H2R00_RS16480	COG0477	Major facilitator Superfamily
H2R00_RS16485	COG2234	aminopeptidase activity
H2R00_RS16495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2R00_RS16500	COG0800	Aldolase
H2R00_RS16505	COG4948	Mandelate Racemase Muconate Lactonizing
H2R00_RS16510	COG2271	Major facilitator Superfamily
H2R00_RS16515	COG5522	Integral membrane protein (intg_mem_TP0381)
H2R00_RS16520	COG2409	Drug exporters of the RND superfamily
H2R00_RS16525	COG2197	response regulator
H2R00_RS16530	COG4585	Histidine kinase
H2R00_RS16540	COG1442	glycosyl transferase family 8
H2R00_RS16545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2R00_RS16550	COG0346	lactoylglutathione lyase activity
H2R00_RS16555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2R00_RS16560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS16565	COG1346	cytolysis
H2R00_RS16570	COG1380	Effector of murein hydrolase LrgA
H2R00_RS16585	COG0583	DNA-binding transcription factor activity
H2R00_RS16590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H2R00_RS16595	COG0352	thiamine-phosphate diphosphorylase activity
H2R00_RS16600	COG1940	carbohydrate kinase activity
H2R00_RS16605	COG2115	Belongs to the xylose isomerase family
H2R00_RS16610	COG1070	Carbohydrate kinase
H2R00_RS16615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2R00_RS16620	COG3162	membrane
H2R00_RS16625	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS16635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2R00_RS16640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2R00_RS16645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2R00_RS16655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2R00_RS16690	COG0456	acetyltransferase
H2R00_RS16710	COG0772	Belongs to the SEDS family
H2R00_RS16715	COG0772	Belongs to the SEDS family
H2R00_RS16720	COG1473	amidohydrolase
H2R00_RS16725	COG0778	Nitroreductase
H2R00_RS16735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2R00_RS16745	COG1404	Belongs to the peptidase S8 family
H2R00_RS16755	COG3711	transcriptional antiterminator
H2R00_RS16760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2R00_RS16760	COG1263	PTS System
H2R00_RS16765	COG1621	beta-fructofuranosidase activity
H2R00_RS16775	COG0351	phosphomethylpyrimidine kinase
H2R00_RS16780	COG1216	Glycosyl transferase, family 2
H2R00_RS16785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H2R00_RS16790	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS16800	COG2233	PERMEase
H2R00_RS16805	COG2363	Small membrane protein
H2R00_RS16820	COG1131	(ABC) transporter
H2R00_RS16840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2R00_RS16855	COG0280	phosphate acetyltransferase
H2R00_RS16865	COG1414	Transcriptional regulator
H2R00_RS16890	COG2814	Major facilitator Superfamily
H2R00_RS16915	COG4844	belongs to the
H2R00_RS16920	COG1078	dGTPase activity
H2R00_RS16925	COG3465	dGTPase activity
H2R00_RS16935	COG1942	4-Oxalocrotonate Tautomerase
H2R00_RS16940	COG1994	Peptidase M50
H2R00_RS16950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2R00_RS16965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2R00_RS16970	COG0010	Belongs to the arginase family
H2R00_RS16975	COG4506	Protein conserved in bacteria
H2R00_RS16980	COG0018	arginyl-trna synthetase
H2R00_RS16990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2R00_RS16995	COG0247	lactate metabolic process
H2R00_RS16995	COG2181	nitrate reductase activity
H2R00_RS17000	COG0183	Belongs to the thiolase family
H2R00_RS17005	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2R00_RS17010	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS17015	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS17020	COG3343	RNA polymerase activity
H2R00_RS17025	COG0504	CTP synthase activity
H2R00_RS17030	COG4821	SIS domain
H2R00_RS17035	COG2204	response regulator
H2R00_RS17040	COG0191	fructose-bisphosphate aldolase activity
H2R00_RS17045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2R00_RS17050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2R00_RS17055	COG1494	fructose-1,6-bisphosphatase
H2R00_RS17060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H2R00_RS17065	COG0254	rRNA binding
H2R00_RS17070	COG1435	thymidine kinase activity
H2R00_RS17075	COG0281	malic enzyme
H2R00_RS17080	COG0679	Auxin Efflux Carrier
H2R00_RS17085	COG0789	Transcriptional regulator
H2R00_RS17090	COG0346	lactoylglutathione lyase activity
H2R00_RS17095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2R00_RS17100	COG2890	protein-(glutamine-N5) methyltransferase activity
H2R00_RS17105	COG1609	Transcriptional regulator
H2R00_RS17110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2R00_RS17115	COG0561	phosphatase activity
H2R00_RS17120	COG0673	inositol 2-dehydrogenase activity
H2R00_RS17125	COG0738	Major facilitator superfamily
H2R00_RS17135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2R00_RS17140	COG0009	L-threonylcarbamoyladenylate synthase
H2R00_RS17145	COG1971	Probably functions as a manganese efflux pump
H2R00_RS17150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2R00_RS17155	COG0698	ribose 5-phosphate isomerase
H2R00_RS17160	COG4475	Protein of unknown function (DUF436)
H2R00_RS17165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2R00_RS17170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H2R00_RS17180	COG0356	it plays a direct role in the translocation of protons across the membrane
H2R00_RS17185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2R00_RS17190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H2R00_RS17195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2R00_RS17200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2R00_RS17205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2R00_RS17210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H2R00_RS17215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2R00_RS17220	COG4836	Membrane
H2R00_RS17230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2R00_RS17235	COG2385	sporulation resulting in formation of a cellular spore
H2R00_RS17240	COG2304	oxidoreductase activity
H2R00_RS17245	COG2304	oxidoreductase activity
H2R00_RS17250	COG3383	formate dehydrogenase (NAD+) activity
H2R00_RS17255	COG2223	nitrite transmembrane transporter activity
H2R00_RS17260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2R00_RS17265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2R00_RS17270	COG1994	Peptidase M50
H2R00_RS17280	COG1959	2 iron, 2 sulfur cluster binding
H2R00_RS17285	COG2910	NAD(P)H-binding
H2R00_RS17295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS17295	COG2207	Transcriptional regulator
H2R00_RS17300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS17305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS17310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS17315	COG2819	hydrolase of the alpha beta superfamily
H2R00_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS17325	COG1169	isochorismate synthase
H2R00_RS17330	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2R00_RS17335	COG1535	isochorismatase
H2R00_RS17335	COG3433	isochorismatase activity
H2R00_RS17340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2R00_RS17345	COG3251	PFAM MbtH domain protein
H2R00_RS17350	COG0477	Major facilitator Superfamily
H2R00_RS17355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2R00_RS17365	COG1247	-acetyltransferase
H2R00_RS17370	COG0739	heme binding
H2R00_RS17380	COG0740	serine-type endopeptidase activity
H2R00_RS17390	COG0347	Belongs to the P(II) protein family
H2R00_RS17395	COG0004	ammonium transporteR
H2R00_RS17400	COG1253	flavin adenine dinucleotide binding
H2R00_RS17405	COG0598	Magnesium transport protein CorA
H2R00_RS17410	COG0517	IMP dehydrogenase activity
H2R00_RS17425	COG3361	conserved protein (COG2071)
H2R00_RS17430	COG3546	catalase activity
H2R00_RS17435	COG1227	inorganic diphosphatase activity
H2R00_RS17440	COG0671	phosphoesterase, PA-phosphatase related
H2R00_RS17445	COG2814	Major facilitator Superfamily
H2R00_RS17450	COG1846	Transcriptional regulator
H2R00_RS17455	COG1609	Transcriptional regulator
H2R00_RS17460	COG1077	Cell shape determining protein MreB Mrl
H2R00_RS17465	COG4786	Flagellar basal body rod
H2R00_RS17470	COG4786	Flagellar basal body rod
H2R00_RS17475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2R00_RS17480	COG1970	mechanosensitive ion channel activity
H2R00_RS17495	COG0629	single-stranded DNA binding
H2R00_RS17515	COG3732	PTS system glucitol sorbitol-specific
H2R00_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS17535	COG1349	DNA-binding transcription factor activity
H2R00_RS17540	COG0561	phosphatase activity
H2R00_RS17555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2R00_RS17560	COG3878	Protein conserved in bacteria
H2R00_RS17565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2R00_RS17570	COG4715	Zinc finger, swim domain protein
H2R00_RS17580	COG3944	biosynthesis protein
H2R00_RS17585	COG4464	protein tyrosine phosphatase activity
H2R00_RS17590	COG2059	Chromate
H2R00_RS17595	COG2059	Chromate
H2R00_RS17600	COG1522	sequence-specific DNA binding
H2R00_RS17605	COG0405	Gamma-glutamyltransferase
H2R00_RS17610	COG0583	DNA-binding transcription factor activity
H2R00_RS17615	COG0028	Belongs to the TPP enzyme family
H2R00_RS17620	COG3527	Alpha-acetolactate decarboxylase
H2R00_RS17625	COG1879	ABC-type sugar transport system periplasmic component
H2R00_RS17630	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2R00_RS17635	COG1129	ABC transporter
H2R00_RS17640	COG1869	D-ribose catabolic process
H2R00_RS17645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2R00_RS17650	COG1609	Transcriptional regulator
H2R00_RS17655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2R00_RS17665	COG2843	Capsule synthesis protein
H2R00_RS17675	COG0791	NLP P60 protein
H2R00_RS17680	COG0561	phosphatase activity
H2R00_RS17685	COG1316	TRANSCRIPTIONal
H2R00_RS17690	COG2814	Major facilitator Superfamily
H2R00_RS17700	COG1063	alcohol dehydrogenase
H2R00_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS17710	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H2R00_RS17715	COG1609	Transcriptional regulator
H2R00_RS17720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2R00_RS17725	COG0800	Aldolase
H2R00_RS17735	COG1328	CTP reductase activity
H2R00_RS17745	COG1482	cell wall glycoprotein biosynthetic process
H2R00_RS17750	COG4193	domain, Protein
H2R00_RS17765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2R00_RS17770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2R00_RS17785	COG4193	domain, Protein
H2R00_RS17790	COG1134	teichoic acid transport
H2R00_RS17795	COG1682	transport, permease protein
H2R00_RS17800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2R00_RS17800	COG0463	Glycosyl transferase, family 2
H2R00_RS17805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2R00_RS17810	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS17815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2R00_RS17820	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H2R00_RS17825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2R00_RS17830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2R00_RS17835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2R00_RS17840	COG1316	TRANSCRIPTIONal
H2R00_RS17855	COG2247	cell wall binding repeat
H2R00_RS17855	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2R00_RS17865	COG2244	polysaccharide biosynthetic process
H2R00_RS17870	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS17870	COG0297	glycogen (starch) synthase activity
H2R00_RS17875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2R00_RS17880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2R00_RS17885	COG3307	-O-antigen
H2R00_RS17890	COG3206	protein involved in exopolysaccharide biosynthesis
H2R00_RS17895	COG1215	transferase activity, transferring glycosyl groups
H2R00_RS17900	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS17905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2R00_RS17915	COG1316	TRANSCRIPTIONal
H2R00_RS17920	COG1739	Uncharacterized protein family UPF0029
H2R00_RS17925	COG4585	Histidine kinase
H2R00_RS17930	COG2197	response regulator
H2R00_RS17935	COG1307	EDD domain protein, DegV family
H2R00_RS17940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H2R00_RS17950	COG1040	competence protein
H2R00_RS17960	COG2747	anti-sigma28 factor FlgM
H2R00_RS17965	COG3418	PFAM FlgN family protein
H2R00_RS17970	COG4786	Flagellar basal body rod
H2R00_RS17970	COG1256	bacterial-type flagellum assembly
H2R00_RS17975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H2R00_RS17985	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H2R00_RS17990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H2R00_RS17995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H2R00_RS18005	COG1334	flagellar protein FlaG
H2R00_RS18010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H2R00_RS18015	COG1516	flagellar protein fliS
H2R00_RS18030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2R00_RS18035	COG0653	protein targeting
H2R00_RS18045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2R00_RS18050	COG2010	Cytochrome c
H2R00_RS18055	COG2884	Cell division ATP-binding protein ftsE
H2R00_RS18060	COG2177	Part of the ABC transporter FtsEX involved in
H2R00_RS18065	COG3883	PFAM NLP P60 protein
H2R00_RS18065	COG0791	NLP P60 protein
H2R00_RS18070	COG0473	3-isopropylmalate dehydrogenase activity
H2R00_RS18075	COG3409	Peptidoglycan-binding domain 1 protein
H2R00_RS18075	COG0793	Belongs to the peptidase S41A family
H2R00_RS18085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2R00_RS18095	COG4897	Protein conserved in bacteria
H2R00_RS18100	COG0556	nucleotide-excision repair
H2R00_RS18105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2R00_RS18125	COG3595	metallopeptidase activity
H2R00_RS18130	COG1983	PspC domain protein
H2R00_RS18135	COG1950	PFAM Membrane protein of
H2R00_RS18140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2R00_RS18145	COG2814	Major facilitator Superfamily
H2R00_RS18150	COG1846	Transcriptional regulator
H2R00_RS18155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H2R00_RS18160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H2R00_RS18165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H2R00_RS18170	COG0546	phosphoglycolate phosphatase activity
H2R00_RS18175	COG0110	maltose O-acetyltransferase activity
H2R00_RS18180	COG5297	Belongs to the glycosyl hydrolase family 6
H2R00_RS18185	COG4990	cell redox homeostasis
H2R00_RS18190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H2R00_RS18195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2R00_RS18200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2R00_RS18205	COG0131	Imidazoleglycerol-phosphate dehydratase
H2R00_RS18210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2R00_RS18215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H2R00_RS18220	COG0107	imidazoleglycerol-phosphate synthase activity
H2R00_RS18225	COG0140	phosphoribosyl-ATP diphosphatase activity
H2R00_RS18225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2R00_RS18230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2R00_RS18235	COG0457	Tetratricopeptide repeat
H2R00_RS18240	COG0492	ferredoxin-NADP+ reductase activity
H2R00_RS18245	COG1051	belongs to the nudix hydrolase family
H2R00_RS18250	COG1660	Displays ATPase and GTPase activities
H2R00_RS18255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H2R00_RS18260	COG1481	regulation of sporulation
H2R00_RS18265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS18270	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H2R00_RS18275	COG2732	(Barnase) inhibitor
H2R00_RS18280	COG4290	ribonuclease
H2R00_RS18285	COG0640	Transcriptional regulator
H2R00_RS18290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2R00_RS18295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2R00_RS18300	COG0288	reversible hydration of carbon dioxide
H2R00_RS18305	COG0659	secondary active sulfate transmembrane transporter activity
H2R00_RS18310	COG1078	dGTPase activity
H2R00_RS18315	COG1694	Mazg nucleotide pyrophosphohydrolase
H2R00_RS18320	COG1611	Belongs to the LOG family
H2R00_RS18325	COG0740	serine-type endopeptidase activity
H2R00_RS18345	COG1621	beta-fructofuranosidase activity
H2R00_RS18350	COG1621	beta-fructofuranosidase activity
H2R00_RS18355	COG1902	pentaerythritol trinitrate reductase activity
H2R00_RS18360	COG1733	regulation of RNA biosynthetic process
H2R00_RS18365	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2R00_RS18370	COG1396	sequence-specific DNA binding
H2R00_RS18375	COG3944	biosynthesis protein
H2R00_RS18380	COG0489	protein tyrosine kinase activity
H2R00_RS18385	COG1086	Polysaccharide biosynthesis protein
H2R00_RS18390	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS18395	COG1215	transferase activity, transferring glycosyl groups
H2R00_RS18400	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS18410	COG1216	Glycosyl transferase, family 2
H2R00_RS18415	COG5039	Polysaccharide pyruvyl transferase
H2R00_RS18420	COG1216	Glycosyl transferase, family 2
H2R00_RS18425	COG2244	polysaccharide biosynthetic process
H2R00_RS18430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2R00_RS18435	COG0110	maltose O-acetyltransferase activity
H2R00_RS18440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2R00_RS18445	COG5039	Polysaccharide pyruvyl transferase
H2R00_RS18455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H2R00_RS18460	COG1620	l-lactate permease
H2R00_RS18465	COG2186	Transcriptional regulator
H2R00_RS18470	COG0247	lactate metabolic process
H2R00_RS18475	COG1139	Iron-sulfur cluster binding protein
H2R00_RS18480	COG1556	Lactate utilization protein
H2R00_RS18500	COG1113	amino acid transport
H2R00_RS18505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2R00_RS18510	COG2390	Transcriptional regulator
H2R00_RS18515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2R00_RS18520	COG0126	phosphoglycerate kinase activity
H2R00_RS18525	COG0149	triose-phosphate isomerase activity
H2R00_RS18530	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2R00_RS18535	COG0148	phosphopyruvate hydratase activity
H2R00_RS18540	COG0693	protein deglycase activity
H2R00_RS18550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS18555	COG4640	response to antibiotic
H2R00_RS18560	COG3064	Membrane
H2R00_RS18565	COG2095	MarC family integral membrane protein
H2R00_RS18570	COG1510	regulation of RNA biosynthetic process
H2R00_RS18575	COG1125	glycine betaine transport
H2R00_RS18575	COG0517	IMP dehydrogenase activity
H2R00_RS18580	COG1174	glycine betaine transport
H2R00_RS18585	COG1732	Glycine betaine
H2R00_RS18590	COG1174	glycine betaine transport
H2R00_RS18595	COG1396	sequence-specific DNA binding
H2R00_RS18600	COG1396	sequence-specific DNA binding
H2R00_RS18605	COG1476	TRANSCRIPTIONal
H2R00_RS18610	COG2002	toxin-antitoxin pair type II binding
H2R00_RS18615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2R00_RS18620	COG1647	Serine aminopeptidase, S33
H2R00_RS18625	COG0557	exoribonuclease II activity
H2R00_RS18630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2R00_RS18670	COG2140	Oxalate decarboxylase
H2R00_RS18680	COG1191	sigma factor activity
H2R00_RS18695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2R00_RS18700	COG0673	inositol 2-dehydrogenase activity
H2R00_RS18715	COG1846	Transcriptional regulator
H2R00_RS18725	COG2124	cytochrome p450
H2R00_RS18735	COG2814	Major facilitator Superfamily
H2R00_RS18740	COG2814	Major facilitator Superfamily
H2R00_RS18745	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS18745	COG3347	Dehydrogenase
H2R00_RS18755	COG4952	isomerase
H2R00_RS18760	COG1070	Carbohydrate kinase
H2R00_RS18765	COG1349	DNA-binding transcription factor activity
H2R00_RS18770	COG0693	protein deglycase activity
H2R00_RS18775	COG1937	Protein conserved in bacteria
H2R00_RS18780	COG2608	mercury ion transmembrane transporter activity
H2R00_RS18785	COG2217	Heavy metal translocating P-type atpase
H2R00_RS18805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS18805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2R00_RS18805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2R00_RS18810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H2R00_RS18810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2R00_RS18825	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2R00_RS18830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2R00_RS18835	COG1121	(ABC) transporter
H2R00_RS18840	COG1472	Belongs to the glycosyl hydrolase 3 family
H2R00_RS18845	COG1501	Belongs to the glycosyl hydrolase 31 family
H2R00_RS18850	COG0395	ABC-type sugar transport system, permease component
H2R00_RS18855	COG1175	transmembrane transport
H2R00_RS18860	COG1653	transport
H2R00_RS18865	COG2217	Heavy metal translocating P-type atpase
H2R00_RS18870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2R00_RS18875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H2R00_RS18880	COG0456	acetyltransferase
H2R00_RS18885	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2R00_RS18885	COG0456	acetyltransferase
H2R00_RS18890	COG2860	membrane
H2R00_RS18895	COG3973	AAA domain
H2R00_RS18905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2R00_RS18910	COG1940	carbohydrate kinase activity
H2R00_RS18915	COG0656	L-ascorbic acid biosynthetic process
H2R00_RS18920	COG2814	Major facilitator Superfamily
H2R00_RS18925	COG1368	sulfuric ester hydrolase activity
H2R00_RS18930	COG1988	membrane-bound metal-dependent
H2R00_RS18940	COG0531	amino acid
H2R00_RS18945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS18950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS18955	COG1120	ATPase activity
H2R00_RS18960	COG0745	RESPONSE REGULATOR receiver
H2R00_RS18965	COG2205	protein histidine kinase activity
H2R00_RS18970	COG1904	glucuronate isomerase
H2R00_RS18975	COG2211	Major facilitator Superfamily
H2R00_RS18980	COG1609	Transcriptional regulator
H2R00_RS18985	COG0246	Mannitol dehydrogenase
H2R00_RS18990	COG2721	sulfolactate sulfo-lyase activity
H2R00_RS19000	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS19005	COG1802	Transcriptional regulator
H2R00_RS19010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS19015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS19020	COG1120	ATPase activity
H2R00_RS19025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2R00_RS19030	COG1454	alcohol dehydrogenase
H2R00_RS19050	COG3395	kinase activity
H2R00_RS19055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2R00_RS19060	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS19065	COG2096	Adenosyltransferase
H2R00_RS19070	COG4677	pectinesterase activity
H2R00_RS19075	COG4758	membrane
H2R00_RS19080	COG1842	Phage shock protein A
H2R00_RS19090	COG4758	membrane
H2R00_RS19095	COG4585	Histidine kinase
H2R00_RS19100	COG2197	response regulator
H2R00_RS19115	COG0814	amino acid
H2R00_RS19120	COG0697	spore germination
H2R00_RS19130	COG0114	fumarate hydratase activity
H2R00_RS19135	COG1309	transcriptional regulator
H2R00_RS19145	COG2770	Histidine kinase
H2R00_RS19145	COG2205	protein histidine kinase activity
H2R00_RS19150	COG0745	RESPONSE REGULATOR receiver
H2R00_RS19155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2R00_RS19160	COG0783	Belongs to the Dps family
H2R00_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS19170	COG1686	Belongs to the peptidase S11 family
H2R00_RS19185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2R00_RS19190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS19195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2R00_RS19200	COG1120	ATPase activity
H2R00_RS19215	COG5577	PFAM Coat F domain
H2R00_RS19230	COG1024	Enoyl-CoA hydratase
H2R00_RS19230	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2R00_RS19235	COG0183	Belongs to the thiolase family
H2R00_RS19240	COG1960	acyl-CoA dehydrogenase activity
H2R00_RS19245	COG1393	Belongs to the ArsC family
H2R00_RS19250	COG0509	glycine decarboxylation via glycine cleavage system
H2R00_RS19260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H2R00_RS19265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS19275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2R00_RS19280	COG2011	ABC-type metal ion transport system permease component
H2R00_RS19285	COG1464	Belongs to the NlpA lipoprotein family
H2R00_RS19290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2R00_RS19305	COG0396	ATPase activity
H2R00_RS19310	COG0719	Fe-S assembly protein
H2R00_RS19315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2R00_RS19320	COG0822	iron-sulfur transferase activity
H2R00_RS19325	COG0719	Fe-S assembly protein
H2R00_RS19345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2R00_RS19355	COG2356	endonuclease I
H2R00_RS19370	COG1288	antiporter activity
H2R00_RS19375	COG2814	Major facilitator Superfamily
H2R00_RS19380	COG2508	Transcriptional regulator
H2R00_RS19385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2R00_RS19395	COG3226	Transcriptional regulator
H2R00_RS19405	COG1801	Protein of unknown function DUF72
H2R00_RS19410	COG0730	response to heat
H2R00_RS19415	COG0737	Belongs to the 5'-nucleotidase family
H2R00_RS19420	COG3377	Domain of unknown function (DUF1805)
H2R00_RS19430	COG0733	neurotransmitter:sodium symporter activity
H2R00_RS19440	COG0739	heme binding
H2R00_RS19455	COG4470	Protein conserved in bacteria
H2R00_RS19460	COG2445	Protein of unknown function DUF86
H2R00_RS19465	COG0647	UMP catabolic process
H2R00_RS19470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2R00_RS19475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2R00_RS19485	COG0460	homoserine dehydrogenase
H2R00_RS19490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2R00_RS19495	COG0083	homoserine kinase activity
H2R00_RS19500	COG0823	Involved in the tonB-independent uptake of proteins
H2R00_RS19500	COG1506	peptidase
H2R00_RS19500	COG4946	Tricorn protease homolog
H2R00_RS19505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H2R00_RS19510	COG4837	Protein of unknown function (DUF1462)
H2R00_RS19520	COG3479	Phenolic acid decarboxylase
H2R00_RS19525	COG0457	Tetratricopeptide repeat
H2R00_RS19535	COG5646	InterPro IPR014922
H2R00_RS19555	COG1252	NADH dehydrogenase
H2R00_RS19560	COG4844	belongs to the
H2R00_RS19565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2R00_RS19570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2R00_RS19575	COG0316	Belongs to the HesB IscA family
H2R00_RS19580	COG0456	acetyltransferase
H2R00_RS19595	COG0492	ferredoxin-NADP+ reductase activity
H2R00_RS19600	COG1252	NADH dehydrogenase
H2R00_RS19615	COG3584	3D domain protein
H2R00_RS19620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H2R00_RS19625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2R00_RS19630	COG2056	Na+-H+ antiporter family
H2R00_RS19635	COG1268	BioY protein
H2R00_RS19640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2R00_RS19650	COG0686	Belongs to the AlaDH PNT family
H2R00_RS19655	COG2508	Transcriptional regulator
H2R00_RS19655	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H2R00_RS19660	COG1115	amino acid carrier protein
H2R00_RS19665	COG4842	Belongs to the WXG100 family
H2R00_RS19670	COG5417	Belongs to the EsaB family
H2R00_RS19675	COG4499	WXG100 protein secretion system (Wss), protein YukC
H2R00_RS19680	COG0433	COG0433 Predicted ATPase
H2R00_RS19680	COG1674	ftsk spoiiie
H2R00_RS19685	COG1511	domain protein
H2R00_RS19700	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS19705	COG1418	mRNA catabolic process
H2R00_RS19715	COG0628	permease
H2R00_RS19730	COG5506	Protein of unknown function (DUF1694)
H2R00_RS19735	COG1335	isochorismatase
H2R00_RS19740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H2R00_RS19745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H2R00_RS19760	COG0142	geranyltranstransferase activity
H2R00_RS19770	COG4585	Histidine kinase
H2R00_RS19775	COG2197	response regulator
H2R00_RS19780	COG2050	protein possibly involved in aromatic compounds catabolism
H2R00_RS19785	COG1320	monovalent cation:proton antiporter activity
H2R00_RS19790	COG2212	antiporter activity
H2R00_RS19795	COG1863	multisubunit Na H antiporter MnhE subunit
H2R00_RS19800	COG0651	ATP synthesis coupled electron transport
H2R00_RS19805	COG1006	Multisubunit Na H antiporter MnhC subunit
H2R00_RS19810	COG2111	Na H antiporter
H2R00_RS19815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2R00_RS19815	COG2111	Na H antiporter
H2R00_RS19825	COG3493	citrate carrier protein
H2R00_RS19830	COG0688	phosphatidylethanolamine metabolic process
H2R00_RS19835	COG0586	Pfam SNARE associated Golgi protein
H2R00_RS19840	COG1183	phosphatidylcholine synthase activity
H2R00_RS19850	COG4565	transcriptional regulatory protein
H2R00_RS19855	COG3290	protein histidine kinase activity
H2R00_RS19865	COG3011	Protein conserved in bacteria
H2R00_RS19870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2R00_RS19875	COG2814	Major facilitator Superfamily
H2R00_RS19880	COG5018	Exonuclease
H2R00_RS19895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2R00_RS19910	COG2267	carboxylic ester hydrolase activity
H2R00_RS19915	COG1522	sequence-specific DNA binding
H2R00_RS19920	COG0436	Aminotransferase
H2R00_RS19925	COG1098	S1 RNA binding domain
H2R00_RS19930	COG2155	Conserved Protein
H2R00_RS19935	COG1979	alcohol dehydrogenase
H2R00_RS19940	COG0166	Belongs to the GPI family
H2R00_RS19950	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H2R00_RS19955	COG2323	membrane
H2R00_RS19965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2R00_RS19980	COG2738	Putative neutral zinc metallopeptidase
H2R00_RS19985	COG1253	flavin adenine dinucleotide binding
H2R00_RS19990	COG5297	Belongs to the glycosyl hydrolase family 6
H2R00_RS20005	COG0366	Alpha amylase catalytic
H2R00_RS20010	COG0432	Pfam Uncharacterised protein family UPF0047
H2R00_RS20015	COG2070	2-Nitropropane dioxygenase
H2R00_RS20025	COG0840	transmembrane signaling receptor activity
H2R00_RS20030	COG0840	transmembrane signaling receptor activity
H2R00_RS20035	COG0840	transmembrane signaling receptor activity
H2R00_RS20040	COG0693	protein deglycase activity
H2R00_RS20045	COG0673	inositol 2-dehydrogenase activity
H2R00_RS20050	COG0628	permease
H2R00_RS20055	COG1968	undecaprenyl-diphosphatase activity
H2R00_RS20060	COG1408	metallophosphoesterase
H2R00_RS20065	COG0726	polysaccharide deacetylase
H2R00_RS20070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2R00_RS20085	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
H2R00_RS20125	COG2140	Oxalate decarboxylase
H2R00_RS20130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2R00_RS20135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2R00_RS20145	COG1510	regulation of RNA biosynthetic process
H2R00_RS20150	COG1012	belongs to the aldehyde dehydrogenase family
H2R00_RS20155	COG1454	alcohol dehydrogenase
H2R00_RS20165	COG2318	DinB family
H2R00_RS20175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2R00_RS20180	COG0569	domain protein
H2R00_RS20185	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H2R00_RS20190	COG0457	Tetratricopeptide repeat
H2R00_RS20205	COG3764	Sortase (surface protein transpeptidase)
H2R00_RS20210	COG3859	Proton-coupled thiamine transporter YuaJ
H2R00_RS20215	COG1609	Transcriptional regulator
H2R00_RS20335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2R00_RS20340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H2R00_RS20345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H2R00_RS20350	COG0297	glycogen (starch) synthase activity
H2R00_RS20355	COG0058	SHG alpha-glucan phosphorylase activity
H2R00_RS20360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2R00_RS20365	COG1575	Belongs to the MenA family. Type 1 subfamily
H2R00_RS20370	COG1169	isochorismate synthase
H2R00_RS20375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H2R00_RS20380	COG0596	Alpha beta hydrolase
H2R00_RS20385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H2R00_RS20390	COG0318	PFAM AMP-dependent synthetase and ligase
H2R00_RS20395	COG4948	Mandelate Racemase Muconate Lactonizing
H2R00_RS20410	COG1294	oxidase, subunit
H2R00_RS20415	COG1271	oxidase subunit
H2R00_RS20420	COG0254	rRNA binding
H2R00_RS20425	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2R00_RS20430	COG0523	cobalamin synthesis protein
H2R00_RS20435	COG0288	reversible hydration of carbon dioxide
H2R00_RS20440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H2R00_RS20445	COG1854	S-ribosylhomocysteine lyase activity
H2R00_RS20460	COG0783	Belongs to the Dps family
H2R00_RS20465	COG4824	toxin secretion phage lysis holin
H2R00_RS20475	COG0494	nUDIX hydrolase
H2R00_RS20480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2R00_RS20485	COG1116	anion transmembrane transporter activity
H2R00_RS20490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2R00_RS20495	COG1506	peptidase
H2R00_RS20510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H2R00_RS20515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2R00_RS20520	COG0367	asparagine synthase
H2R00_RS20525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2R00_RS20525	COG0438	transferase activity, transferring glycosyl groups
H2R00_RS20530	COG0671	phosphoesterase, PA-phosphatase related
H2R00_RS20535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2R00_RS20540	COG2267	carboxylic ester hydrolase activity
H2R00_RS20550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H2R00_RS20555	COG1242	4 iron, 4 sulfur cluster binding
H2R00_RS20565	COG1725	Transcriptional regulator
H2R00_RS20570	COG1131	(ABC) transporter
H2R00_RS20580	COG1136	(ABC) transporter
H2R00_RS20585	COG0577	efflux transmembrane transporter activity
H2R00_RS20590	COG2433	Pfam Transposase IS66
H2R00_RS20600	COG2814	Major facilitator Superfamily
H2R00_RS20610	COG0495	leucyl-tRNA aminoacylation
H2R00_RS20615	COG0346	lactoylglutathione lyase activity
H2R00_RS20620	COG0583	DNA-binding transcription factor activity
H2R00_RS20630	COG1073	alpha beta
H2R00_RS20635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2R00_RS20640	COG0395	ABC-type sugar transport system, permease component
H2R00_RS20645	COG1653	transport
H2R00_RS20650	COG2207	Transcriptional regulator
H2R00_RS20655	COG4209	transmembrane transport
H2R00_RS20660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H2R00_RS20665	COG1653	transport
H2R00_RS20670	COG0673	inositol 2-dehydrogenase activity
H2R00_RS20675	COG5578	integral membrane protein
H2R00_RS20685	COG0457	Tetratricopeptide repeat
H2R00_RS20690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2R00_RS20700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2R00_RS20705	COG2081	HI0933 family
H2R00_RS20710	COG2244	polysaccharide biosynthetic process
H2R00_RS20715	COG1187	pseudouridine synthase activity
H2R00_RS20720	COG1349	DNA-binding transcription factor activity
H2R00_RS20725	COG1131	(ABC) transporter
H2R00_RS20730	COG4473	ABC transporter
H2R00_RS20735	COG2252	PERMEase
H2R00_RS20740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2R00_RS20755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2R00_RS20760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H2R00_RS20770	COG1597	lipid kinase activity
H2R00_RS20775	COG1523	belongs to the glycosyl hydrolase 13 family
H2R00_RS20780	COG0510	thiamine kinase activity
H2R00_RS20790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2R00_RS20795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2R00_RS20800	COG0281	malic enzyme
H2R00_RS20805	COG5584	Small secreted protein
H2R00_RS20810	COG1363	Peptidase, m42
H2R00_RS20820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2R00_RS20825	COG4848	Belongs to the UPF0354 family
H2R00_RS20830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2R00_RS20835	COG1674	ftsk spoiiie
H2R00_RS20840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2R00_RS20845	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H2R00_RS20850	COG4980	gas vesicle protein
H2R00_RS20855	COG3118	belongs to the thioredoxin family
H2R00_RS20865	COG1605	Chorismate mutase
H2R00_RS20865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2R00_RS20870	COG1609	Transcriptional regulator
H2R00_RS20875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H2R00_RS20880	COG1360	Flagellar Motor Protein
H2R00_RS20885	COG0123	including yeast histone deacetylase and acetoin utilization protein
H2R00_RS20890	COG0517	IMP dehydrogenase activity
H2R00_RS20895	COG0454	-acetyltransferase
H2R00_RS20900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2R00_RS20905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2R00_RS20915	COG1522	sequence-specific DNA binding
H2R00_RS20920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H2R00_RS20925	COG3152	Membrane
H2R00_RS20935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H2R00_RS20940	COG2203	Gaf domain
H2R00_RS20940	COG2199	diguanylate cyclase activity
H2R00_RS20945	COG1956	GAF domain-containing protein
H2R00_RS20950	COG1309	transcriptional regulator
H2R00_RS20955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2R00_RS20960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H2R00_RS20965	COG1114	Component of the transport system for branched-chain amino acids
H2R00_RS20970	COG1104	cysteine desulfurase activity
H2R00_RS20975	COG0301	tRNA thio-modification
H2R00_RS20985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2R00_RS20995	COG0477	Major facilitator Superfamily
H2R00_RS21000	COG1566	PFAM secretion protein HlyD family protein
H2R00_RS21005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2R00_RS21010	COG0616	signal peptide processing
H2R00_RS21015	COG1714	RDD family
H2R00_RS21025	COG3874	Sporulation protein YtfJ
H2R00_RS21030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H2R00_RS21035	COG0827	DNA restriction-modification system
H2R00_RS21040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2R00_RS21045	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2R00_RS21050	COG0137	argininosuccinate synthase activity
H2R00_RS21055	COG0165	Argininosuccinate lyase
H2R00_RS21065	COG1028	Short-chain dehydrogenase reductase Sdr
H2R00_RS21070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H2R00_RS21075	COG1695	Transcriptional regulator