locus-tag	class	description
B4U37_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4U37_RS00010	COG0592	DNA-directed DNA polymerase activity
B4U37_RS00015	COG2501	S4 domain
B4U37_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U37_RS00030	COG0187	DNA topoisomerase II activity
B4U37_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U37_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B4U37_RS00075	COG0516	GMP reductase activity
B4U37_RS00075	COG0517	IMP dehydrogenase activity
B4U37_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4U37_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4U37_RS00105	COG1428	Deoxynucleoside kinase
B4U37_RS00110	COG1428	Deoxynucleoside kinase
B4U37_RS00115	COG1388	LysM domain
B4U37_RS00115	COG3858	chitin binding
B4U37_RS00120	COG1335	isochorismatase
B4U37_RS00125	COG0590	tRNA wobble adenosine to inosine editing
B4U37_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4U37_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4U37_RS00180	COG1982	Orn Lys Arg decarboxylase major
B4U37_RS00190	COG3870	Protein conserved in bacteria
B4U37_RS00195	COG1728	Protein conserved in bacteria
B4U37_RS00200	COG0470	DNA polymerase III
B4U37_RS00205	COG1774	PSP1 C-terminal conserved region
B4U37_RS00210	COG4467	Involved in initiation control of chromosome replication
B4U37_RS00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4U37_RS00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4U37_RS00225	COG2002	toxin-antitoxin pair type II binding
B4U37_RS00235	COG0084	hydrolase, TatD family'
B4U37_RS00240	COG3583	domain protein
B4U37_RS00240	COG3584	3D domain protein
B4U37_RS00250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4U37_RS00260	COG4466	Protein conserved in bacteria
B4U37_RS00270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4U37_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U37_RS00280	COG0251	oxidation-reduction process
B4U37_RS00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4U37_RS00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4U37_RS00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4U37_RS00320	COG2002	toxin-antitoxin pair type II binding
B4U37_RS00325	COG2244	polysaccharide biosynthetic process
B4U37_RS00330	COG3956	TIGRFAM MazG family protein
B4U37_RS00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4U37_RS00350	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4U37_RS00355	COG1098	S1 RNA binding domain
B4U37_RS00370	COG2208	phosphoserine phosphatase activity
B4U37_RS00380	COG2304	oxidoreductase activity
B4U37_RS00385	COG0515	serine threonine protein kinase
B4U37_RS00395	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4U37_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U37_RS00405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4U37_RS00410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4U37_RS00415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U37_RS00420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_RS00425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U37_RS00430	COG0512	Glutamine amidotransferase of anthranilate synthase
B4U37_RS00435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U37_RS00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4U37_RS00445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4U37_RS00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4U37_RS00455	COG1396	sequence-specific DNA binding
B4U37_RS00460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U37_RS00465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U37_RS00500	COG3880	PFAM UvrB UvrC protein
B4U37_RS00505	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4U37_RS00510	COG0542	response to heat
B4U37_RS00515	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4U37_RS00525	COG4956	integral membrane protein (PIN domain superfamily)
B4U37_RS00530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4U37_RS00535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4U37_RS00545	COG1045	serine acetyltransferase
B4U37_RS00550	COG0215	cysteine-tRNA ligase activity
B4U37_RS00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U37_RS00565	COG3688	RNA-binding protein containing a PIN domain
B4U37_RS00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U37_RS00580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U37_RS00585	COG0250	Participates in transcription elongation, termination and antitermination
B4U37_RS00590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B4U37_RS00595	COG0081	regulation of translation
B4U37_RS00600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4U37_RS00605	COG0222	ribosome binding
B4U37_RS00610	COG2813	Specifically methylates the guanine in position
B4U37_RS00615	COG0085	RNA polymerase activity
B4U37_RS00620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4U37_RS00625	COG1358	cellular component organization or biogenesis
B4U37_RS00630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4U37_RS00635	COG0049	tRNA binding
B4U37_RS00640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U37_RS00645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U37_RS00650	COG0051	transcription antitermination factor activity, RNA binding
B4U37_RS00655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4U37_RS00660	COG0088	Forms part of the polypeptide exit tunnel
B4U37_RS00665	COG0089	rRNA binding
B4U37_RS00670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4U37_RS00675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4U37_RS00680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4U37_RS00690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4U37_RS00695	COG0255	Belongs to the universal ribosomal protein uL29 family
B4U37_RS00700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4U37_RS00705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4U37_RS00710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B4U37_RS00720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U37_RS00725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4U37_RS00730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4U37_RS00740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4U37_RS00745	COG1841	ribosomal large subunit assembly
B4U37_RS00750	COG0200	Binds to the 23S rRNA
B4U37_RS00755	COG0201	protein transport
B4U37_RS00760	COG0563	adenylate kinase activity
B4U37_RS00765	COG0024	Methionine aminopeptidase
B4U37_RS00770	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B4U37_RS00775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4U37_RS00780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4U37_RS00785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4U37_RS00800	COG0203	ribosomal protein L17
B4U37_RS00805	COG1122	ATPase activity
B4U37_RS00810	COG1122	ATPase activity
B4U37_RS00815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4U37_RS00820	COG0101	tRNA pseudouridine synthase activity
B4U37_RS00825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4U37_RS00830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4U37_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS00860	COG0489	protein tyrosine kinase activity
B4U37_RS00870	COG2194	sulfuric ester hydrolase activity
B4U37_RS00875	COG0726	polysaccharide deacetylase
B4U37_RS00950	COG1595	DNA-templated transcription, initiation
B4U37_RS00955	COG5662	AntiSigma factor
B4U37_RS00960	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4U37_RS00965	COG4856	YbbR-like protein
B4U37_RS00970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U37_RS00985	COG0531	amino acid
B4U37_RS00990	COG0697	spore germination
B4U37_RS01000	COG1114	Component of the transport system for branched-chain amino acids
B4U37_RS01005	COG1802	Transcriptional regulator
B4U37_RS01015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B4U37_RS01020	COG0492	ferredoxin-NADP+ reductase activity
B4U37_RS01035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4U37_RS01040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U37_RS01045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U37_RS01080	COG0840	transmembrane signaling receptor activity
B4U37_RS01095	COG5577	PFAM Coat F domain
B4U37_RS01105	COG0393	Putative heavy-metal-binding
B4U37_RS01110	COG1649	PFAM Uncharacterised BCR, COG1649
B4U37_RS01115	COG0789	Transcriptional regulator
B4U37_RS01120	COG1253	flavin adenine dinucleotide binding
B4U37_RS01125	COG4536	flavin adenine dinucleotide binding
B4U37_RS01130	COG0772	Belongs to the SEDS family
B4U37_RS01160	COG1695	Transcriptional regulator
B4U37_RS01170	COG4585	Histidine kinase
B4U37_RS01180	COG1131	(ABC) transporter
B4U37_RS01205	COG0840	transmembrane signaling receptor activity
B4U37_RS01210	COG1595	DNA-templated transcription, initiation
B4U37_RS01220	COG3942	CHAP domain
B4U37_RS01220	COG1388	LysM domain
B4U37_RS01225	COG1410	methionine synthase
B4U37_RS01225	COG0646	methionine synthase
B4U37_RS01230	COG0646	methionine synthase
B4U37_RS01230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4U37_RS01235	COG0626	cystathionine gamma-synthase activity
B4U37_RS01240	COG0626	cystathionine gamma-synthase activity
B4U37_RS01245	COG4988	ABC transporter
B4U37_RS01250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4U37_RS01260	COG1132	(ABC) transporter
B4U37_RS01270	COG0723	plastoquinol--plastocyanin reductase activity
B4U37_RS01270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_RS01285	COG4134	Bacterial extracellular solute-binding protein
B4U37_RS01305	COG1213	nucleotidyl transferase
B4U37_RS01305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U37_RS01310	COG3237	CsbD-like
B4U37_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS01330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4U37_RS01335	COG3973	AAA domain
B4U37_RS01350	COG1937	Protein conserved in bacteria
B4U37_RS01355	COG2608	mercury ion transmembrane transporter activity
B4U37_RS01360	COG2217	Heavy metal translocating P-type atpase
B4U37_RS01380	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_RS01390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4U37_RS01395	COG0513	Belongs to the DEAD box helicase family
B4U37_RS01400	COG4294	response to UV
B4U37_RS01405	COG3402	PFAM membrane-flanked domain
B4U37_RS01410	COG3428	Bacterial PH domain
B4U37_RS01415	COG0705	Rhomboid family
B4U37_RS01420	COG0736	holo-[acyl-carrier-protein] synthase activity
B4U37_RS01425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4U37_RS01435	COG0864	Transcriptional regulator
B4U37_RS01440	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4U37_RS01445	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS01450	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS01455	COG2172	sigma factor antagonist activity
B4U37_RS01460	COG2208	phosphoserine phosphatase activity
B4U37_RS01465	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS01470	COG2172	sigma factor antagonist activity
B4U37_RS01475	COG1191	sigma factor activity
B4U37_RS01480	COG2208	phosphoserine phosphatase activity
B4U37_RS01490	COG2183	response to ionizing radiation
B4U37_RS01500	COG3091	SprT-like family
B4U37_RS01590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4U37_RS01595	COG0802	atpase or kinase
B4U37_RS01600	COG1214	PFAM Peptidase M22, glycoprotease
B4U37_RS01605	COG0456	acetyltransferase
B4U37_RS01620	COG1131	(ABC) transporter
B4U37_RS01635	COG0488	(ABC) transporter
B4U37_RS01640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4U37_RS01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U37_RS01650	COG0805	protein transport
B4U37_RS01665	COG1266	CAAX protease self-immunity
B4U37_RS01670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4U37_RS01675	COG0459	protein refolding
B4U37_RS01680	COG0582	viral genome integration into host DNA
B4U37_RS01750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4U37_RS01780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U37_RS01785	COG1136	(ABC) transporter
B4U37_RS01790	COG0577	efflux transmembrane transporter activity
B4U37_RS01805	COG5002	protein histidine kinase activity
B4U37_RS01855	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS01990	COG0697	spore germination
B4U37_RS02000	COG0300	oxidoreductase activity
B4U37_RS02005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4U37_RS02010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4U37_RS02015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U37_RS02020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U37_RS02030	COG1733	regulation of RNA biosynthetic process
B4U37_RS02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U37_RS02045	COG0482	sulfurtransferase activity
B4U37_RS02070	COG1525	nuclease
B4U37_RS02080	COG0598	Magnesium transport protein CorA
B4U37_RS02085	COG2182	Extracellular solute-binding protein
B4U37_RS02090	COG1609	Transcriptional regulator
B4U37_RS02105	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS02115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U37_RS02120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U37_RS02135	COG1278	Cold shock
B4U37_RS02140	COG1329	Transcriptional regulator
B4U37_RS02150	COG5002	protein histidine kinase activity
B4U37_RS02150	COG3850	Histidine kinase
B4U37_RS02155	COG1136	(ABC) transporter
B4U37_RS02160	COG0577	efflux transmembrane transporter activity
B4U37_RS02170	COG2172	sigma factor antagonist activity
B4U37_RS02180	COG0714	Associated with various cellular activities
B4U37_RS02185	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4U37_RS02190	COG1305	Transglutaminase-like
B4U37_RS02195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4U37_RS02195	COG0519	Catalyzes the synthesis of GMP from XMP
B4U37_RS02200	COG2252	PERMEase
B4U37_RS02225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_RS02230	COG1131	(ABC) transporter
B4U37_RS02250	COG1595	DNA-templated transcription, initiation
B4U37_RS02265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_RS02270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4U37_RS02280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4U37_RS02285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4U37_RS02290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4U37_RS02300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4U37_RS02305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U37_RS02310	COG0047	phosphoribosylformylglycinamidine synthase activity
B4U37_RS02315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U37_RS02320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4U37_RS02330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4U37_RS02335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4U37_RS02345	COG0151	Belongs to the GarS family
B4U37_RS02355	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U37_RS02360	COG1470	cell adhesion involved in biofilm formation
B4U37_RS02365	COG4496	protein, YerC YecD
B4U37_RS02370	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4U37_RS02375	COG0210	DNA helicase
B4U37_RS02385	COG4851	CamS sex pheromone cAM373 precursor
B4U37_RS02405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_RS02410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U37_RS02415	COG0154	amidase activity
B4U37_RS02425	COG1876	peptidase activity
B4U37_RS02430	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4U37_RS02435	COG2268	Band 7 protein
B4U37_RS02440	COG1597	lipid kinase activity
B4U37_RS02460	COG0306	phosphate transporter
B4U37_RS02465	COG2046	Belongs to the sulfate adenylyltransferase family
B4U37_RS02470	COG0529	Catalyzes the synthesis of activated sulfate
B4U37_RS02475	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U37_RS02490	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4U37_RS02510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U37_RS02515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4U37_RS02535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4U37_RS02540	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B4U37_RS02545	COG1349	DNA-binding transcription factor activity
B4U37_RS02560	COG0561	phosphatase activity
B4U37_RS02565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS02575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS02595	COG2233	PERMEase
B4U37_RS02600	COG0583	DNA-binding transcription factor activity
B4U37_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS02660	COG3708	Transcriptional regulator
B4U37_RS02660	COG2207	Transcriptional regulator
B4U37_RS02710	COG1595	DNA-templated transcription, initiation
B4U37_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS02740	COG0456	acetyltransferase
B4U37_RS02740	COG1846	Transcriptional regulator
B4U37_RS02745	COG0601	transmembrane transport
B4U37_RS02780	COG3546	catalase activity
B4U37_RS02785	COG1263	PTS System
B4U37_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_RS02785	COG2190	(PTS) system
B4U37_RS02810	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U37_RS02830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U37_RS02835	COG1113	amino acid transport
B4U37_RS02840	COG2814	Major facilitator Superfamily
B4U37_RS02850	COG1280	lysine exporter protein (LysE YggA)
B4U37_RS02860	COG1834	amidinotransferase
B4U37_RS02875	COG0778	Nitroreductase
B4U37_RS02935	COG3655	Transcriptional regulator
B4U37_RS02955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U37_RS02995	COG0210	DNA helicase
B4U37_RS03000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U37_RS03005	COG3344	reverse transcriptase
B4U37_RS03010	COG0583	DNA-binding transcription factor activity
B4U37_RS03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS03075	COG3340	Belongs to the peptidase S51 family
B4U37_RS03090	COG0500	methyltransferase
B4U37_RS03090	COG3615	Tellurite resistance protein tehB
B4U37_RS03125	COG2814	Major facilitator Superfamily
B4U37_RS03130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U37_RS03135	COG2814	Major facilitator Superfamily
B4U37_RS03140	COG0300	oxidoreductase activity
B4U37_RS03145	COG3973	AAA domain
B4U37_RS03160	COG1595	DNA-templated transcription, initiation
B4U37_RS03170	COG1247	-acetyltransferase
B4U37_RS03190	COG2226	methyltransferase
B4U37_RS03195	COG2124	cytochrome p450
B4U37_RS03275	COG1404	Belongs to the peptidase S8 family
B4U37_RS03300	COG1968	undecaprenyl-diphosphatase activity
B4U37_RS03315	COG0785	Cytochrome C biogenesis protein
B4U37_RS03335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS03340	COG2318	DinB family
B4U37_RS03345	COG1794	racemase activity, acting on amino acids and derivatives
B4U37_RS03365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS03370	COG1063	alcohol dehydrogenase
B4U37_RS03395	COG1476	TRANSCRIPTIONal
B4U37_RS03415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4U37_RS03415	COG0456	acetyltransferase
B4U37_RS03455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS03485	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_RS03485	COG3341	Caulimovirus viroplasmin
B4U37_RS03540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS03555	COG0488	(ABC) transporter
B4U37_RS03570	COG5444	nuclease activity
B4U37_RS03590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U37_RS03595	COG2356	endonuclease I
B4U37_RS03610	COG0456	acetyltransferase
B4U37_RS03615	COG1522	sequence-specific DNA binding
B4U37_RS03625	COG0640	Transcriptional regulator
B4U37_RS03635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U37_RS03640	COG2205	protein histidine kinase activity
B4U37_RS03645	COG0745	RESPONSE REGULATOR receiver
B4U37_RS03650	COG1136	(ABC) transporter
B4U37_RS03655	COG0577	efflux transmembrane transporter activity
B4U37_RS03750	COG4326	sporulation control protein
B4U37_RS03765	COG1268	BioY protein
B4U37_RS03770	COG0300	oxidoreductase activity
B4U37_RS03775	COG1595	DNA-templated transcription, initiation
B4U37_RS03785	COG1595	DNA-templated transcription, initiation
B4U37_RS03810	COG5002	protein histidine kinase activity
B4U37_RS03815	COG1607	acyl-coa hydrolase
B4U37_RS03820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B4U37_RS03830	COG1132	(ABC) transporter
B4U37_RS03845	COG0628	permease
B4U37_RS03850	COG1695	Transcriptional regulator
B4U37_RS03870	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS03885	COG0681	Belongs to the peptidase S26 family
B4U37_RS03890	COG3227	Zinc metalloprotease (Elastase)
B4U37_RS03900	COG1404	Belongs to the peptidase S8 family
B4U37_RS03905	COG1309	transcriptional regulator
B4U37_RS03910	COG2814	Major facilitator Superfamily
B4U37_RS03915	COG2329	Antibiotic biosynthesis monooxygenase
B4U37_RS03930	COG0322	excinuclease ABC activity
B4U37_RS03950	COG3290	protein histidine kinase activity
B4U37_RS03955	COG3279	Response regulator of the LytR AlgR family
B4U37_RS03965	COG4555	ABC transporter
B4U37_RS03970	COG1668	transmembrane transport
B4U37_RS03980	COG3711	transcriptional antiterminator
B4U37_RS04010	COG2186	Transcriptional regulator
B4U37_RS04020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_RS04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_RS04040	COG0673	inositol 2-dehydrogenase activity
B4U37_RS04055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U37_RS04060	COG1183	phosphatidylcholine synthase activity
B4U37_RS04070	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS04075	COG1966	Carbon starvation protein
B4U37_RS04080	COG5002	protein histidine kinase activity
B4U37_RS04085	COG0166	Belongs to the GPI family
B4U37_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS04095	COG2814	Major facilitator Superfamily
B4U37_RS04100	COG4895	conserved protein (DUF2196)
B4U37_RS04110	COG2368	4-hydroxyphenylacetate
B4U37_RS04115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U37_RS04125	COG0154	amidase activity
B4U37_RS04130	COG1132	(ABC) transporter
B4U37_RS04135	COG1132	(ABC) transporter
B4U37_RS04140	COG1115	amino acid carrier protein
B4U37_RS04145	COG2200	EAL domain
B4U37_RS04155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_RS04155	COG0723	plastoquinol--plastocyanin reductase activity
B4U37_RS04160	COG0513	Belongs to the DEAD box helicase family
B4U37_RS04165	COG2124	cytochrome p450
B4U37_RS04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_RS04195	COG2244	polysaccharide biosynthetic process
B4U37_RS04200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_RS04205	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4U37_RS04210	COG1077	Cell shape determining protein MreB Mrl
B4U37_RS04255	COG1486	melibiose metabolic process
B4U37_RS04260	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4U37_RS04265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U37_RS04270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U37_RS04275	COG2188	Transcriptional regulator
B4U37_RS04280	COG0745	RESPONSE REGULATOR receiver
B4U37_RS04285	COG5002	protein histidine kinase activity
B4U37_RS04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_RS04295	COG1988	membrane-bound metal-dependent
B4U37_RS04300	COG4840	Belongs to the UPF0435 family
B4U37_RS04310	COG1295	ribonuclease BN
B4U37_RS04315	COG2217	Heavy metal translocating P-type atpase
B4U37_RS04340	COG1595	DNA-templated transcription, initiation
B4U37_RS04350	COG0477	Major facilitator Superfamily
B4U37_RS04360	COG0024	Methionine aminopeptidase
B4U37_RS04375	COG1737	Transcriptional regulator
B4U37_RS04390	COG1175	transmembrane transport
B4U37_RS04395	COG0395	ABC-type sugar transport system, permease component
B4U37_RS04400	COG3842	ATPase activity
B4U37_RS04410	COG3876	Protein conserved in bacteria
B4U37_RS04415	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U37_RS04420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B4U37_RS04425	COG0247	lactate metabolic process
B4U37_RS04430	COG0277	FAD linked oxidase domain protein
B4U37_RS04435	COG3835	regulator
B4U37_RS04445	COG2364	Membrane
B4U37_RS04460	COG0535	radical SAM domain protein
B4U37_RS04485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4U37_RS04490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U37_RS04495	COG4807	Protein conserved in bacteria
B4U37_RS04500	COG0673	inositol 2-dehydrogenase activity
B4U37_RS04510	COG4213	ABC transporter substrate-binding protein
B4U37_RS04520	COG4214	carbohydrate transport
B4U37_RS04530	COG2972	Histidine kinase
B4U37_RS04535	COG2197	response regulator
B4U37_RS04540	COG4213	ABC transporter substrate-binding protein
B4U37_RS04545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U37_RS04550	COG0697	spore germination
B4U37_RS04555	COG3239	Fatty acid desaturase
B4U37_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U37_RS04645	COG3119	arylsulfatase activity
B4U37_RS04650	COG1280	lysine exporter protein (LysE YggA)
B4U37_RS04685	COG3773	Cell wall hydrolase
B4U37_RS04720	COG0697	spore germination
B4U37_RS04750	COG0398	Pfam SNARE associated Golgi protein
B4U37_RS04765	COG1657	PFAM Prenyltransferase squalene oxidase
B4U37_RS04775	COG0745	RESPONSE REGULATOR receiver
B4U37_RS04780	COG5002	protein histidine kinase activity
B4U37_RS04825	COG2267	carboxylic ester hydrolase activity
B4U37_RS04860	COG0791	NLP P60 protein
B4U37_RS04860	COG1388	LysM domain
B4U37_RS04875	COG0494	nUDIX hydrolase
B4U37_RS04890	COG1388	LysM domain
B4U37_RS04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS04930	COG1120	ATPase activity
B4U37_RS04935	COG2207	Transcriptional regulator
B4U37_RS04995	COG1595	DNA-templated transcription, initiation
B4U37_RS05010	COG1131	(ABC) transporter
B4U37_RS05015	COG3711	transcriptional antiterminator
B4U37_RS05020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_RS05020	COG2190	(PTS) system
B4U37_RS05020	COG1263	PTS System
B4U37_RS05030	COG0716	FMN binding
B4U37_RS05040	COG0716	FMN binding
B4U37_RS05045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U37_RS05055	COG0697	spore germination
B4U37_RS05065	COG3069	C4-dicarboxylate transmembrane transporter activity
B4U37_RS05105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4U37_RS05110	COG2208	phosphoserine phosphatase activity
B4U37_RS05115	COG3403	YqcI/YcgG family
B4U37_RS05120	COG4191	Histidine kinase
B4U37_RS05125	COG1757	Na H antiporter
B4U37_RS05135	COG1070	Carbohydrate kinase
B4U37_RS05170	COG1090	epimerase
B4U37_RS05180	COG0300	oxidoreductase activity
B4U37_RS05205	COG1988	membrane-bound metal-dependent
B4U37_RS05215	COG1194	a g-specific adenine glycosylase
B4U37_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS05240	COG3557	Belongs to the UPF0374 family
B4U37_RS05245	COG1132	(ABC) transporter
B4U37_RS05250	COG4129	membrane
B4U37_RS05255	COG0069	glutamate synthase activity
B4U37_RS05255	COG0070	glutamate synthase
B4U37_RS05255	COG0067	glutamate synthase
B4U37_RS05265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U37_RS05270	COG4555	ABC transporter
B4U37_RS05290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4U37_RS05295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4U37_RS05300	COG2096	Adenosyltransferase
B4U37_RS05305	COG0735	belongs to the Fur family
B4U37_RS05425	COG3382	B3 4 domain protein
B4U37_RS05440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4U37_RS05445	COG2766	serine protein kinase
B4U37_RS05460	COG3279	Response regulator of the LytR AlgR family
B4U37_RS05465	COG2972	Histidine kinase
B4U37_RS05470	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS05475	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS05480	COG0601	transmembrane transport
B4U37_RS05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS05495	COG0747	negative chemotaxis
B4U37_RS05500	COG0402	S-adenosylhomocysteine deaminase activity
B4U37_RS05505	COG0402	S-adenosylhomocysteine deaminase activity
B4U37_RS05515	COG2205	protein histidine kinase activity
B4U37_RS05530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS05535	COG0601	transmembrane transport
B4U37_RS05540	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS05545	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS05550	COG0747	negative chemotaxis
B4U37_RS05555	COG0601	transmembrane transport
B4U37_RS05560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS05565	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS05570	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS05580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U37_RS05595	COG1115	amino acid carrier protein
B4U37_RS05600	COG2514	catechol 2,3-dioxygenase activity
B4U37_RS05630	COG0346	lactoylglutathione lyase activity
B4U37_RS05635	COG1253	flavin adenine dinucleotide binding
B4U37_RS05640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_RS05645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_RS05645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_RS05655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U37_RS05660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U37_RS05665	COG2205	protein histidine kinase activity
B4U37_RS05675	COG0789	Transcriptional regulator
B4U37_RS05685	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U37_RS05695	COG0656	L-ascorbic acid biosynthetic process
B4U37_RS05710	COG0564	pseudouridine synthase activity
B4U37_RS05725	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4U37_RS05730	COG0366	Alpha amylase catalytic
B4U37_RS05735	COG3153	acetyltransferase
B4U37_RS05735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_RS05745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U37_RS05755	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_RS05760	COG1501	Belongs to the glycosyl hydrolase 31 family
B4U37_RS05770	COG2188	Transcriptional regulator
B4U37_RS05775	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS05790	COG1175	transmembrane transport
B4U37_RS05795	COG0395	ABC-type sugar transport system, permease component
B4U37_RS05800	COG2188	Transcriptional regulator
B4U37_RS05805	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4U37_RS05810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U37_RS05815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U37_RS05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U37_RS05825	COG2203	Gaf domain
B4U37_RS05825	COG4585	Histidine kinase
B4U37_RS05830	COG2197	response regulator
B4U37_RS05835	COG0431	NADPH-dependent FMN reductase
B4U37_RS05845	COG2866	Carboxypeptidase
B4U37_RS05850	COG2239	Acts as a magnesium transporter
B4U37_RS05855	COG0730	response to heat
B4U37_RS05860	COG2719	SpoVR family
B4U37_RS05870	COG1349	DNA-binding transcription factor activity
B4U37_RS05875	COG1105	Belongs to the carbohydrate kinase PfkB family
B4U37_RS05880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_RS05880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U37_RS05880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U37_RS05895	COG1695	Transcriptional regulator
B4U37_RS05905	COG2112	serine threonine protein kinase
B4U37_RS05920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4U37_RS05930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U37_RS05935	COG0569	domain protein
B4U37_RS05940	COG0398	Pfam SNARE associated Golgi protein
B4U37_RS05975	COG0582	viral genome integration into host DNA
B4U37_RS06000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U37_RS06030	COG0586	Pfam SNARE associated Golgi protein
B4U37_RS06040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_RS06045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_RS06050	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS06055	COG4989	oxidoreductase activity
B4U37_RS06065	COG1301	dicarboxylic acid transport
B4U37_RS06080	COG1309	transcriptional regulator
B4U37_RS06095	COG0589	response to stress
B4U37_RS06100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U37_RS06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS06125	COG2814	Major facilitator Superfamily
B4U37_RS06130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4U37_RS06135	COG4721	ABC-type cobalt transport system, permease component
B4U37_RS06140	COG1122	ATPase activity
B4U37_RS06150	COG0352	thiamine-phosphate diphosphorylase activity
B4U37_RS06155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_RS06160	COG2104	thiamine diphosphate biosynthetic process
B4U37_RS06165	COG2022	thiamine diphosphate biosynthetic process
B4U37_RS06170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U37_RS06175	COG0351	phosphomethylpyrimidine kinase
B4U37_RS06190	COG1278	Cold shock
B4U37_RS06200	COG1132	(ABC) transporter
B4U37_RS06205	COG1132	(ABC) transporter
B4U37_RS06210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U37_RS06215	COG0765	amino acid transport
B4U37_RS06220	COG1126	abc transporter atp-binding protein
B4U37_RS06245	COG3842	ATPase activity
B4U37_RS06250	COG2508	Transcriptional regulator
B4U37_RS06270	COG0189	ligase activity
B4U37_RS06275	COG0189	ligase activity
B4U37_RS06280	COG0189	ligase activity
B4U37_RS06285	COG4399	Belongs to the UPF0754 family
B4U37_RS06295	COG0561	phosphatase activity
B4U37_RS06300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U37_RS06315	COG1024	Enoyl-CoA hydratase
B4U37_RS06330	COG4152	abc transporter atp-binding protein
B4U37_RS06335	COG1668	transmembrane transport
B4U37_RS06345	COG0420	3'-5' exonuclease activity
B4U37_RS06350	COG4717	serine-type aminopeptidase activity
B4U37_RS06355	COG2814	Major facilitator Superfamily
B4U37_RS06360	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4U37_RS06370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U37_RS06405	COG1846	Transcriptional regulator
B4U37_RS06425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4U37_RS06435	COG0537	adenosine 5'-monophosphoramidase activity
B4U37_RS06440	COG1131	(ABC) transporter
B4U37_RS06445	COG4473	ABC transporter
B4U37_RS06455	COG1473	amidohydrolase
B4U37_RS06470	COG4585	Histidine kinase
B4U37_RS06475	COG2197	response regulator
B4U37_RS06480	COG2329	Antibiotic biosynthesis monooxygenase
B4U37_RS06485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_RS06490	COG4191	Histidine kinase
B4U37_RS06495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4U37_RS06500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4U37_RS06505	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4U37_RS06510	COG1309	transcriptional regulator
B4U37_RS06515	COG1511	domain protein
B4U37_RS06520	COG1609	Transcriptional regulator
B4U37_RS06535	COG1234	tRNA 3'-trailer cleavage
B4U37_RS06540	COG0095	Lipoate-protein ligase
B4U37_RS06545	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_RS06550	COG1024	Enoyl-CoA hydratase
B4U37_RS06565	COG0501	Belongs to the peptidase M48B family
B4U37_RS06570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B4U37_RS06575	COG2224	Isocitrate lyase
B4U37_RS06585	COG4903	ComK protein
B4U37_RS06590	COG2323	membrane
B4U37_RS06595	COG2323	membrane
B4U37_RS06605	COG0823	Involved in the tonB-independent uptake of proteins
B4U37_RS06605	COG4946	Tricorn protease homolog
B4U37_RS06605	COG1506	peptidase
B4U37_RS06630	COG0398	Pfam SNARE associated Golgi protein
B4U37_RS06650	COG0411	ABC transporter
B4U37_RS06660	COG0559	Belongs to the binding-protein-dependent transport system permease family
B4U37_RS06670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS06700	COG0706	membrane insertase activity
B4U37_RS06705	COG2814	Major facilitator Superfamily
B4U37_RS06710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4U37_RS06720	COG0420	3'-5' exonuclease activity
B4U37_RS06725	COG0419	ATPase involved in DNA repair
B4U37_RS06730	COG1403	HNH endonuclease
B4U37_RS06770	COG2311	Membrane
B4U37_RS06780	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U37_RS06785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U37_RS06795	COG5001	Diguanylate cyclase
B4U37_RS06795	COG3300	MHYT domain
B4U37_RS06805	COG0367	asparagine synthase
B4U37_RS06820	COG1562	ergosterol biosynthetic process
B4U37_RS06825	COG1233	COG1233 Phytoene dehydrogenase and related
B4U37_RS06830	COG1215	transferase activity, transferring glycosyl groups
B4U37_RS06845	COG0004	ammonium transporteR
B4U37_RS06850	COG0347	Belongs to the P(II) protein family
B4U37_RS06855	COG0534	Mate efflux family protein
B4U37_RS06860	COG2207	Transcriptional regulator
B4U37_RS06860	COG1917	Cupin 2, conserved barrel domain protein
B4U37_RS06870	COG2182	Extracellular solute-binding protein
B4U37_RS06875	COG1175	transmembrane transport
B4U37_RS06880	COG3833	ABC-type maltose transport systems, permease component
B4U37_RS06885	COG1874	Beta-galactosidase
B4U37_RS06885	COG0366	Alpha amylase catalytic
B4U37_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS06905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS06910	COG1666	GTP binding
B4U37_RS06915	COG2996	Protein conserved in bacteria
B4U37_RS06925	COG1307	EDD domain protein, DegV family
B4U37_RS06930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_RS06940	COG0561	phosphatase activity
B4U37_RS06945	COG1073	alpha beta
B4U37_RS06950	COG2151	metal-sulfur cluster biosynthetic enzyme
B4U37_RS06965	COG0542	response to heat
B4U37_RS06975	COG2267	carboxylic ester hydrolase activity
B4U37_RS06985	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U37_RS07000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_RS07005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U37_RS07015	COG5504	Zn-dependent protease
B4U37_RS07020	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS07025	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS07035	COG0601	transmembrane transport
B4U37_RS07040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS07055	COG0180	Tryptophanyl-tRNA synthetase
B4U37_RS07065	COG4166	transmembrane transport
B4U37_RS07070	COG0601	transmembrane transport
B4U37_RS07075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS07080	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS07085	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS07100	COG0456	acetyltransferase
B4U37_RS07110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS07115	COG4605	iron ion homeostasis
B4U37_RS07120	COG4604	ABC transporter, ATP-binding protein
B4U37_RS07125	COG4607	ABC-type enterochelin transport system periplasmic component
B4U37_RS07140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U37_RS07145	COG1393	Belongs to the ArsC family
B4U37_RS07150	COG0861	Integral membrane protein TerC family
B4U37_RS07155	COG4862	establishment of competence for transformation
B4U37_RS07160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U37_RS07170	COG1164	Oligoendopeptidase f
B4U37_RS07175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U37_RS07180	COG2346	COG2346, Truncated hemoglobins
B4U37_RS07190	COG0741	lytic transglycosylase activity
B4U37_RS07195	COG4116	CYTH
B4U37_RS07205	COG2357	RelA SpoT domain protein
B4U37_RS07215	COG0564	pseudouridine synthase activity
B4U37_RS07220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U37_RS07225	COG0475	glutathione-regulated potassium exporter activity
B4U37_RS07225	COG0589	response to stress
B4U37_RS07230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4U37_RS07270	COG0438	transferase activity, transferring glycosyl groups
B4U37_RS07330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_RS07340	COG2323	membrane
B4U37_RS07370	COG0210	DNA helicase
B4U37_RS07380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS07385	COG2323	membrane
B4U37_RS07390	COG2153	protein acetylation
B4U37_RS07395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4U37_RS07400	COG2382	esterase
B4U37_RS07420	COG1999	signal sequence binding
B4U37_RS07425	COG1418	mRNA catabolic process
B4U37_RS07490	COG1363	Peptidase, m42
B4U37_RS07505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4U37_RS07525	COG2894	cell division
B4U37_RS07545	COG1533	DNA photolyase activity
B4U37_RS07555	COG2720	vancomycin resistance protein
B4U37_RS07570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U37_RS07575	COG4106	trans-aconitate 2-methyltransferase activity
B4U37_RS07580	COG3584	3D domain protein
B4U37_RS07580	COG1388	LysM domain
B4U37_RS07590	COG0671	phosphoesterase, PA-phosphatase related
B4U37_RS07610	COG3844	kynureninase activity
B4U37_RS07650	COG0668	transmembrane transport
B4U37_RS07675	COG1793	dna ligase
B4U37_RS07675	COG3285	dna ligase
B4U37_RS07680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4U37_RS07685	COG3320	Male sterility
B4U37_RS07685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_RS07695	COG1191	sigma factor activity
B4U37_RS07710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U37_RS07735	COG0395	ABC-type sugar transport system, permease component
B4U37_RS07755	COG5002	protein histidine kinase activity
B4U37_RS07760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U37_RS07775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4U37_RS07780	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4U37_RS07785	COG1278	Cold shock
B4U37_RS07790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_RS07795	COG0436	Aminotransferase
B4U37_RS07800	COG1850	ribulose-bisphosphate carboxylase activity
B4U37_RS07805	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B4U37_RS07810	COG0235	Class ii aldolase
B4U37_RS07815	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4U37_RS07825	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U37_RS07835	COG2861	carbohydrate metabolic process
B4U37_RS07855	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B4U37_RS07865	COG3639	organic phosphonate transmembrane transporter activity
B4U37_RS07870	COG0737	Belongs to the 5'-nucleotidase family
B4U37_RS07875	COG1846	Transcriptional regulator
B4U37_RS07885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U37_RS07905	COG0542	response to heat
B4U37_RS07915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U37_RS07925	COG3949	Membrane
B4U37_RS07930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_RS07955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4U37_RS07960	COG0720	synthase
B4U37_RS07970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4U37_RS07985	COG0702	epimerase
B4U37_RS07995	COG4873	Protein conserved in bacteria
B4U37_RS08050	COG1725	Transcriptional regulator
B4U37_RS08055	COG1131	(ABC) transporter
B4U37_RS08065	COG1131	(ABC) transporter
B4U37_RS08070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_RS08095	COG0018	arginyl-trna synthetase
B4U37_RS08110	COG2267	carboxylic ester hydrolase activity
B4U37_RS08125	COG3546	catalase activity
B4U37_RS08130	COG1388	LysM domain
B4U37_RS08130	COG0791	NLP P60 protein
B4U37_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS08165	COG2986	histidine ammonia-lyase
B4U37_RS08175	COG1228	amidohydrolase
B4U37_RS08180	COG0010	Belongs to the arginase family
B4U37_RS08185	COG2084	Dehydrogenase
B4U37_RS08190	COG4191	Histidine kinase
B4U37_RS08195	COG0733	neurotransmitter:sodium symporter activity
B4U37_RS08200	COG1404	Belongs to the peptidase S8 family
B4U37_RS08210	COG1595	DNA-templated transcription, initiation
B4U37_RS08225	COG0436	Aminotransferase
B4U37_RS08245	COG2252	PERMEase
B4U37_RS08255	COG2205	protein histidine kinase activity
B4U37_RS08270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS08275	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U37_RS08305	COG1473	amidohydrolase
B4U37_RS08320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4U37_RS08325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_RS08335	COG3594	Acyltransferase
B4U37_RS08360	COG0488	(ABC) transporter
B4U37_RS08380	COG3180	Ammonia monooxygenase
B4U37_RS08385	COG2814	Major facilitator Superfamily
B4U37_RS08400	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_RS08410	COG5522	Integral membrane protein (intg_mem_TP0381)
B4U37_RS08435	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS08440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_RS08445	COG1595	DNA-templated transcription, initiation
B4U37_RS08475	COG4842	Belongs to the WXG100 family
B4U37_RS08480	COG5417	Belongs to the EsaB family
B4U37_RS08485	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U37_RS08490	COG1674	ftsk spoiiie
B4U37_RS08490	COG0433	COG0433 Predicted ATPase
B4U37_RS08495	COG1511	domain protein
B4U37_RS08505	COG3290	protein histidine kinase activity
B4U37_RS08505	COG3829	transcription factor binding
B4U37_RS08510	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_RS08520	COG0183	Belongs to the thiolase family
B4U37_RS08530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B4U37_RS08535	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_RS08560	COG1595	DNA-templated transcription, initiation
B4U37_RS08565	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS08570	COG0745	RESPONSE REGULATOR receiver
B4U37_RS08575	COG5002	protein histidine kinase activity
B4U37_RS08580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U37_RS08605	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_RS08615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U37_RS08625	COG4667	esterase of the alpha-beta hydrolase superfamily
B4U37_RS08630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_RS08640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4U37_RS08650	COG0129	dihydroxy-acid dehydratase activity
B4U37_RS08655	COG0028	Belongs to the TPP enzyme family
B4U37_RS08660	COG0440	acetolactate synthase activity
B4U37_RS08665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4U37_RS08670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_RS08680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U37_RS08685	COG0066	3-isopropylmalate dehydratase activity
B4U37_RS08700	COG4589	Belongs to the CDS family
B4U37_RS08710	COG0110	maltose O-acetyltransferase activity
B4U37_RS08720	COG1216	Glycosyl transferase, family 2
B4U37_RS08725	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS08735	COG0702	epimerase
B4U37_RS08745	COG3610	response to peptide
B4U37_RS08750	COG2966	Psort location CytoplasmicMembrane, score
B4U37_RS08755	COG2340	Cysteine-rich secretory protein family
B4U37_RS08760	COG2188	Transcriptional regulator
B4U37_RS08765	COG0363	glucosamine-6-phosphate deaminase activity
B4U37_RS08770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U37_RS08775	COG1247	-acetyltransferase
B4U37_RS08785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS08800	COG1686	Belongs to the peptidase S11 family
B4U37_RS08815	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS08825	COG4145	pantothenate transmembrane transporter activity
B4U37_RS08835	COG2333	competence protein COMEC
B4U37_RS08835	COG0658	competence protein
B4U37_RS08850	COG2190	(PTS) system
B4U37_RS08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_RS08855	COG1263	PTS System
B4U37_RS08860	COG0366	Alpha amylase catalytic
B4U37_RS08865	COG0366	Alpha amylase catalytic
B4U37_RS08870	COG2188	Transcriptional regulator
B4U37_RS08880	COG0835	chemotaxis
B4U37_RS08880	COG0784	Response regulator, receiver
B4U37_RS08890	COG3437	response regulator, receiver
B4U37_RS08890	COG2770	Histidine kinase
B4U37_RS08895	COG1376	ErfK ybiS ycfS ynhG family protein
B4U37_RS08905	COG1408	metallophosphoesterase
B4U37_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS08925	COG2200	EAL domain
B4U37_RS08950	COG4703	Protein of unknown function (DUF1797)
B4U37_RS08955	COG5506	Protein of unknown function (DUF1694)
B4U37_RS08970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4U37_RS08980	COG0517	IMP dehydrogenase activity
B4U37_RS08985	COG0477	Major facilitator Superfamily
B4U37_RS08995	COG0583	DNA-binding transcription factor activity
B4U37_RS09010	COG1473	amidohydrolase
B4U37_RS09025	COG0668	transmembrane transport
B4U37_RS09030	COG0450	alkyl hydroperoxide reductase
B4U37_RS09035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS09040	COG1132	(ABC) transporter
B4U37_RS09045	COG1132	(ABC) transporter
B4U37_RS09055	COG0569	domain protein
B4U37_RS09060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_RS09070	COG0697	spore germination
B4U37_RS09075	COG0561	phosphatase activity
B4U37_RS09095	COG0022	dehydrogenase e1 component
B4U37_RS09100	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_RS09105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_RS09140	COG1982	Orn Lys Arg decarboxylase major
B4U37_RS09150	COG4476	Belongs to the UPF0223 family
B4U37_RS09155	COG4493	Belongs to the UPF0637 family
B4U37_RS09165	COG0483	inositol monophosphate 1-phosphatase activity
B4U37_RS09175	COG1217	gtp-binding protein TYPA
B4U37_RS09195	COG4896	Protein conserved in bacteria
B4U37_RS09215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4U37_RS09220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U37_RS09225	COG2066	Belongs to the glutaminase family
B4U37_RS09230	COG4838	Belongs to the UPF0358 family
B4U37_RS09235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4U37_RS09240	COG0415	Belongs to the DNA photolyase family
B4U37_RS09245	COG1612	heme a metabolic process
B4U37_RS09280	COG3336	cytochrome c oxidase
B4U37_RS09290	COG0628	permease
B4U37_RS09305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4U37_RS09310	COG2340	Cysteine-rich secretory protein family
B4U37_RS09340	COG3679	Belongs to the UPF0342 family
B4U37_RS09350	COG4471	UPF0298 protein
B4U37_RS09365	COG0742	ribosomal rna small subunit methyltransferase
B4U37_RS09370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4U37_RS09375	COG3314	Sporulation integral membrane protein YlbJ
B4U37_RS09380	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U37_RS09385	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U37_RS09390	COG1323	Belongs to the UPF0348 family
B4U37_RS09395	COG1399	metal-binding, possibly nucleic acid-binding protein
B4U37_RS09400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B4U37_RS09405	COG1024	Enoyl-CoA hydratase
B4U37_RS09415	COG3011	Protein conserved in bacteria
B4U37_RS09425	COG0454	-acetyltransferase
B4U37_RS09430	COG0439	Biotin carboxylase
B4U37_RS09435	COG0511	ligase activity, forming carbon-carbon bonds
B4U37_RS09440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U37_RS09445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4U37_RS09455	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4U37_RS09460	COG2001	Belongs to the MraZ family
B4U37_RS09465	COG0275	rRNA processing
B4U37_RS09475	COG0768	penicillin binding
B4U37_RS09485	COG0768	penicillin binding
B4U37_RS09495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U37_RS09500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U37_RS09505	COG0772	Belongs to the SEDS family
B4U37_RS09510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4U37_RS09515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4U37_RS09520	COG3879	Bacterial protein of unknown function (DUF881)
B4U37_RS09525	COG3879	Bacterial protein of unknown function (DUF881)
B4U37_RS09530	COG3856	small basic protein
B4U37_RS09535	COG0849	cell division
B4U37_RS09540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4U37_RS09550	COG1191	sigma factor activity
B4U37_RS09555	COG1191	sigma factor activity
B4U37_RS09560	COG1873	PFAM PRC-barrel domain
B4U37_RS09565	COG1496	oxidoreductase activity
B4U37_RS09570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4U37_RS09575	COG1799	cell septum assembly
B4U37_RS09580	COG0762	integral membrane protein
B4U37_RS09585	COG2302	S4 RNA-binding domain
B4U37_RS09590	COG3599	regulation of cell shape
B4U37_RS09600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4U37_RS09605	COG0564	pseudouridine synthase activity
B4U37_RS09610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4U37_RS09615	COG2233	PERMEase
B4U37_RS09620	COG0540	Belongs to the ATCase OTCase family
B4U37_RS09625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U37_RS09640	COG0543	2 iron, 2 sulfur cluster binding
B4U37_RS09650	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U37_RS09655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4U37_RS09675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U37_RS09680	COG1561	YicC-like family, N-terminal region
B4U37_RS09685	COG2052	Domain of unknown function (DUF370)
B4U37_RS09695	COG1758	RNA polymerase activity
B4U37_RS09700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U37_RS09705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4U37_RS09715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U37_RS09720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4U37_RS09720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U37_RS09725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4U37_RS09730	COG0631	protein serine/threonine phosphatase activity
B4U37_RS09735	COG2815	serine threonine protein kinase
B4U37_RS09735	COG0515	serine threonine protein kinase
B4U37_RS09740	COG1162	GTPase activity
B4U37_RS09745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4U37_RS09755	COG1564	THIamine pyrophosphokinase
B4U37_RS09765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4U37_RS09775	COG1302	Protein conserved in bacteria
B4U37_RS09780	COG1461	Dihydroxyacetone kinase
B4U37_RS09785	COG1760	l-serine dehydratase
B4U37_RS09790	COG1760	l-serine dehydratase
B4U37_RS09795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4U37_RS09800	COG2050	protein possibly involved in aromatic compounds catabolism
B4U37_RS09800	COG1349	DNA-binding transcription factor activity
B4U37_RS09805	COG0416	fatty acid biosynthetic process
B4U37_RS09810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4U37_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS09820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_RS09825	COG0571	ribonuclease III activity
B4U37_RS09830	COG1196	nuclear chromosome segregation
B4U37_RS09835	COG0552	protein localization to endoplasmic reticulum
B4U37_RS09845	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4U37_RS09850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4U37_RS09860	COG1837	Belongs to the UPF0109 family
B4U37_RS09865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4U37_RS09900	COG2257	FlhB HrpN YscU SpaS Family
B4U37_RS09910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4U37_RS09915	COG0758	DNA mediated transformation
B4U37_RS09920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_RS09925	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4U37_RS09930	COG4974	Belongs to the 'phage' integrase family
B4U37_RS09935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4U37_RS09940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4U37_RS09945	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4U37_RS09950	COG1815	bacterial-type flagellum-dependent cell motility
B4U37_RS09955	COG1558	bacterial-type flagellum-dependent cell motility
B4U37_RS09960	COG1677	Flagellar hook-basal body complex protein FliE
B4U37_RS09965	COG1766	The M ring may be actively involved in energy transduction
B4U37_RS09970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_RS09975	COG1317	bacterial-type flagellum organization
B4U37_RS09980	COG1157	protein secretion by the type III secretion system
B4U37_RS09995	COG3144	bacterial-type flagellum assembly
B4U37_RS10000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4U37_RS10020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_RS10025	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_RS10025	COG1776	CheC inhibitor of MCP methylation
B4U37_RS10030	COG2201	protein-glutamate methylesterase activity
B4U37_RS10035	COG3190	flagellar
B4U37_RS10040	COG1338	Plays a role in the flagellum-specific transport system
B4U37_RS10045	COG1987	bacterial-type flagellum assembly
B4U37_RS10050	COG1684	flagellar biosynthetic protein fliR
B4U37_RS10055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U37_RS10060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U37_RS10065	COG1419	protein localization to endoplasmic reticulum
B4U37_RS10070	COG0455	bacterial-type flagellum organization
B4U37_RS10075	COG2201	protein-glutamate methylesterase activity
B4U37_RS10080	COG2198	Histidine kinase
B4U37_RS10080	COG0643	Histidine kinase
B4U37_RS10085	COG0835	chemotaxis
B4U37_RS10090	COG1776	CheC inhibitor of MCP methylation
B4U37_RS10095	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B4U37_RS10100	COG1191	sigma factor activity
B4U37_RS10110	COG0052	Belongs to the universal ribosomal protein uS2 family
B4U37_RS10135	COG4589	Belongs to the CDS family
B4U37_RS10140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4U37_RS10145	COG0750	zinc metalloprotease
B4U37_RS10155	COG2176	DNA-directed DNA polymerase activity
B4U37_RS10165	COG0195	Participates in both transcription termination and antitermination
B4U37_RS10170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4U37_RS10175	COG1358	cellular component organization or biogenesis
B4U37_RS10185	COG1550	Protein conserved in bacteria
B4U37_RS10190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4U37_RS10195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4U37_RS10200	COG0196	riboflavin kinase activity
B4U37_RS10205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4U37_RS10210	COG1185	polyribonucleotide nucleotidyltransferase activity
B4U37_RS10215	COG0726	polysaccharide deacetylase
B4U37_RS10220	COG0612	Peptidase, M16
B4U37_RS10225	COG1873	PFAM PRC-barrel domain
B4U37_RS10230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_RS10235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U37_RS10240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4U37_RS10245	COG0527	aspartate kinase activity
B4U37_RS10250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U37_RS10260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_RS10265	COG0740	serine-type endopeptidase activity
B4U37_RS10275	COG4980	gas vesicle protein
B4U37_RS10275	COG1674	ftsk spoiiie
B4U37_RS10280	COG2188	Transcriptional regulator
B4U37_RS10285	COG0612	Peptidase, M16
B4U37_RS10290	COG0612	Peptidase, M16
B4U37_RS10295	COG0300	oxidoreductase activity
B4U37_RS10310	COG1426	Protein conserved in bacteria
B4U37_RS10315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U37_RS10320	COG1058	Belongs to the CinA family
B4U37_RS10320	COG1546	Belongs to the CinA family
B4U37_RS10335	COG1418	mRNA catabolic process
B4U37_RS10340	COG1692	metallophosphoesterase
B4U37_RS10345	COG2359	stage V sporulation protein S
B4U37_RS10360	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4U37_RS10365	COG1063	alcohol dehydrogenase
B4U37_RS10370	COG0156	8-amino-7-oxononanoate synthase activity
B4U37_RS10375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U37_RS10380	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4U37_RS10395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4U37_RS10400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4U37_RS10415	COG0464	growth
B4U37_RS10420	COG1233	COG1233 Phytoene dehydrogenase and related
B4U37_RS10430	COG2860	membrane
B4U37_RS10435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4U37_RS10440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4U37_RS10450	COG0789	Transcriptional regulator
B4U37_RS10455	COG0174	glutamine synthetase
B4U37_RS10475	COG2323	membrane
B4U37_RS10480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U37_RS10485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U37_RS10490	COG4224	UPF0291 protein
B4U37_RS10505	COG3763	UPF0154 protein
B4U37_RS10510	COG1132	(ABC) transporter
B4U37_RS10515	COG1132	(ABC) transporter
B4U37_RS10525	COG0785	Cytochrome C biogenesis protein
B4U37_RS10530	COG2201	protein-glutamate methylesterase activity
B4U37_RS10535	COG4846	Membrane protein involved in cytochrome C biogenesis
B4U37_RS10545	COG1484	DNA-dependent DNA replication
B4U37_RS10550	COG0714	Associated with various cellular activities
B4U37_RS10565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_RS10570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4U37_RS10575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4U37_RS10620	COG1131	(ABC) transporter
B4U37_RS10670	COG1921	L-seryl-tRNASec selenium transferase activity
B4U37_RS10690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4U37_RS10700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS10730	COG0824	Thioesterase
B4U37_RS10740	COG4841	protein insertion into membrane
B4U37_RS10745	COG2843	Capsule synthesis protein
B4U37_RS10785	COG4326	sporulation control protein
B4U37_RS10790	COG0588	phosphoglycerate mutase activity
B4U37_RS10800	COG0346	lactoylglutathione lyase activity
B4U37_RS10805	COG1056	cytidyltransferase-related domain
B4U37_RS10805	COG1051	belongs to the nudix hydrolase family
B4U37_RS10810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4U37_RS10815	COG1832	CoA-binding protein
B4U37_RS10820	COG0187	DNA topoisomerase II activity
B4U37_RS10825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U37_RS10835	COG1335	isochorismatase
B4U37_RS10840	COG0590	tRNA wobble adenosine to inosine editing
B4U37_RS10855	COG1733	regulation of RNA biosynthetic process
B4U37_RS10875	COG1131	(ABC) transporter
B4U37_RS10880	COG1309	transcriptional regulator
B4U37_RS10905	COG1054	Belongs to the UPF0176 family
B4U37_RS10910	COG3459	Glycosyltransferase 36 associated
B4U37_RS10915	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U37_RS10920	COG1823	symporter activity
B4U37_RS10925	COG3906	Belongs to the UPF0473 family
B4U37_RS10945	COG2197	response regulator
B4U37_RS10950	COG4585	Histidine kinase
B4U37_RS10955	COG1994	Peptidase M50
B4U37_RS10965	COG1271	oxidase subunit
B4U37_RS10970	COG1294	oxidase, subunit
B4U37_RS10990	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B4U37_RS10995	COG4565	transcriptional regulatory protein
B4U37_RS11000	COG3290	protein histidine kinase activity
B4U37_RS11005	COG2391	methyltransferase activity
B4U37_RS11020	COG0662	Cupin 2, conserved barrel domain protein
B4U37_RS11025	COG0346	lactoylglutathione lyase activity
B4U37_RS11035	COG1714	RDD family
B4U37_RS11050	COG0714	Associated with various cellular activities
B4U37_RS11070	COG0322	excinuclease ABC activity
B4U37_RS11075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_RS11080	COG1785	Belongs to the alkaline phosphatase family
B4U37_RS11085	COG1082	Xylose isomerase domain protein TIM barrel
B4U37_RS11095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_RS11115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_RS11115	COG2207	Transcriptional regulator
B4U37_RS11125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4U37_RS11135	COG0003	Pfam Anion-transporting ATPase
B4U37_RS11145	COG1966	Carbon starvation protein
B4U37_RS11160	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_RS11165	COG2353	YceI-like domain
B4U37_RS11185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U37_RS11205	COG2309	aminopeptidase activity
B4U37_RS11225	COG0708	Exodeoxyribonuclease III
B4U37_RS11245	COG0644	oxidoreductase
B4U37_RS11250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U37_RS11260	COG0583	DNA-binding transcription factor activity
B4U37_RS11265	COG0372	Belongs to the citrate synthase family
B4U37_RS11270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U37_RS11285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U37_RS11290	COG1295	ribonuclease BN
B4U37_RS11295	COG1834	amidinotransferase
B4U37_RS11305	COG2340	Cysteine-rich secretory protein family
B4U37_RS11310	COG0673	inositol 2-dehydrogenase activity
B4U37_RS11315	COG0693	protein deglycase activity
B4U37_RS11320	COG0165	Argininosuccinate lyase
B4U37_RS11325	COG0137	argininosuccinate synthase activity
B4U37_RS11330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U37_RS11335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U37_RS11340	COG0505	Belongs to the CarA family
B4U37_RS11345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U37_RS11355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4U37_RS11370	COG0673	inositol 2-dehydrogenase activity
B4U37_RS11390	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_RS11400	COG2223	nitrite transmembrane transporter activity
B4U37_RS11415	COG0346	lactoylglutathione lyase activity
B4U37_RS11420	COG2404	hydrolase activity, acting on ester bonds
B4U37_RS11425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_RS11440	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS11465	COG0488	(ABC) transporter
B4U37_RS11470	COG0628	permease
B4U37_RS11480	COG1272	protein, Hemolysin III
B4U37_RS11490	COG2133	pyrroloquinoline quinone binding
B4U37_RS11510	COG3773	Cell wall hydrolase
B4U37_RS11535	COG0406	alpha-ribazole phosphatase activity
B4U37_RS11540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B4U37_RS11550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_RS11555	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B4U37_RS11560	COG1120	ATPase activity
B4U37_RS11565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS11570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_RS11575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B4U37_RS11580	COG1492	cobalamin metabolic process
B4U37_RS11590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B4U37_RS11605	COG1335	isochorismatase
B4U37_RS11610	COG1683	Conserved Protein
B4U37_RS11625	COG0492	ferredoxin-NADP+ reductase activity
B4U37_RS11630	COG1959	2 iron, 2 sulfur cluster binding
B4U37_RS11635	COG3853	Toxic anion resistance protein (TelA)
B4U37_RS11645	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS11660	COG0671	phosphoesterase, PA-phosphatase related
B4U37_RS11665	COG4548	von Willebrand factor, type A
B4U37_RS11670	COG0714	Associated with various cellular activities
B4U37_RS11675	COG0861	Integral membrane protein TerC family
B4U37_RS11680	COG0534	Mate efflux family protein
B4U37_RS11690	COG2340	Cysteine-rich secretory protein family
B4U37_RS11700	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U37_RS11705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U37_RS11710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_RS11715	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B4U37_RS11720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_RS11725	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_RS11750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_RS11755	COG4120	Belongs to the binding-protein-dependent transport system permease family
B4U37_RS11775	COG3327	negative regulation of DNA-templated transcription, initiation
B4U37_RS11780	COG0183	Belongs to the thiolase family
B4U37_RS11785	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS11795	COG1024	Enoyl-CoA hydratase
B4U37_RS11825	COG3396	Phenylacetate-CoA oxygenase
B4U37_RS11830	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B4U37_RS11845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U37_RS11850	COG0400	carboxylic ester hydrolase activity
B4U37_RS11870	COG1876	peptidase activity
B4U37_RS11875	COG0432	Pfam Uncharacterised protein family UPF0047
B4U37_RS11905	COG4479	Belongs to the UPF0346 family
B4U37_RS11915	COG1509	lysine 2,3-aminomutase activity
B4U37_RS11920	COG3829	transcription factor binding
B4U37_RS11925	COG0456	acetyltransferase
B4U37_RS11940	COG0697	spore germination
B4U37_RS11945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U37_RS11955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U37_RS11960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U37_RS11965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U37_RS11970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U37_RS11980	COG0840	transmembrane signaling receptor activity
B4U37_RS11995	COG2755	lipolytic protein G-D-S-L family
B4U37_RS12000	COG1131	(ABC) transporter
B4U37_RS12005	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_RS12010	COG1562	ergosterol biosynthetic process
B4U37_RS12070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_RS12070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_RS12090	COG0789	Transcriptional regulator
B4U37_RS12095	COG3275	phosphorelay sensor kinase activity
B4U37_RS12105	COG1966	Carbon starvation protein
B4U37_RS12135	COG2755	lipolytic protein G-D-S-L family
B4U37_RS12140	COG1999	signal sequence binding
B4U37_RS12145	COG2814	Major facilitator Superfamily
B4U37_RS12165	COG0714	Associated with various cellular activities
B4U37_RS12180	COG1131	(ABC) transporter
B4U37_RS12235	COG2135	peptidase activity
B4U37_RS12260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U37_RS12270	COG2136	Putative SAM-dependent methyltransferase
B4U37_RS12270	COG2521	methyltransferase
B4U37_RS12280	COG1413	lyase activity
B4U37_RS12285	COG0488	(ABC) transporter
B4U37_RS12290	COG1418	mRNA catabolic process
B4U37_RS12305	COG1307	EDD domain protein, DegV family
B4U37_RS12315	COG0386	Belongs to the glutathione peroxidase family
B4U37_RS12325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U37_RS12350	COG2808	Putative FMN-binding domain
B4U37_RS12355	COG4555	ABC transporter
B4U37_RS12380	COG0390	transport system, permease component
B4U37_RS12385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U37_RS12390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_RS12390	COG0551	DNA topoisomerase type I activity
B4U37_RS12400	COG1278	Cold shock
B4U37_RS12415	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_RS12420	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_RS12430	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4U37_RS12440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_RS12465	COG3541	Predicted nucleotidyltransferase
B4U37_RS12470	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U37_RS12475	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4U37_RS12480	COG3424	synthase
B4U37_RS12495	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4U37_RS12505	COG1199	ATP-dependent helicase activity
B4U37_RS12525	COG0116	Belongs to the methyltransferase superfamily
B4U37_RS12550	COG3359	exonuclease
B4U37_RS12555	COG1111	helicase
B4U37_RS12555	COG1205	dead DEAH box helicase
B4U37_RS12615	COG3331	DNA recombination
B4U37_RS12620	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U37_RS12620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_RS12630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4U37_RS12635	COG3935	DnaD domain protein
B4U37_RS12640	COG0017	Asparaginyl-tRNA synthetase
B4U37_RS12660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4U37_RS12660	COG1199	ATP-dependent helicase activity
B4U37_RS12665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4U37_RS12685	COG0617	tRNA 3'-terminal CCA addition
B4U37_RS12690	COG0438	transferase activity, transferring glycosyl groups
B4U37_RS12695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U37_RS12700	COG1803	Methylglyoxal synthase
B4U37_RS12710	COG1694	Mazg nucleotide pyrophosphohydrolase
B4U37_RS12715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_RS12720	COG2738	Putative neutral zinc metallopeptidase
B4U37_RS12730	COG4347	Protein of unknown function (DUF1405)
B4U37_RS12740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4U37_RS12760	COG5582	Belongs to the UPF0302 family
B4U37_RS12765	COG0457	Tetratricopeptide repeat
B4U37_RS12775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4U37_RS12780	COG0287	Prephenate dehydrogenase
B4U37_RS12785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_RS12790	COG0159	tryptophan synthase activity
B4U37_RS12795	COG0133	tryptophan synthase activity
B4U37_RS12800	COG0135	phosphoribosylanthranilate isomerase activity
B4U37_RS12805	COG0134	indole-3-glycerol-phosphate synthase activity
B4U37_RS12810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U37_RS12820	COG4401	Chorismate mutase type I
B4U37_RS12825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4U37_RS12830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4U37_RS12835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4U37_RS12840	COG0105	UTP biosynthetic process
B4U37_RS12845	COG0142	geranyltranstransferase activity
B4U37_RS12850	COG2226	methyltransferase
B4U37_RS12855	COG0142	geranyltranstransferase activity
B4U37_RS12865	COG0302	gtp cyclohydrolase
B4U37_RS12870	COG0776	regulation of translation
B4U37_RS12875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U37_RS12925	COG1304	FMN binding
B4U37_RS12930	COG0539	negative regulation of cytoplasmic translation
B4U37_RS12940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4U37_RS12955	COG2959	enzyme of heme biosynthesis
B4U37_RS12960	COG3773	Cell wall hydrolase
B4U37_RS12960	COG3409	Peptidoglycan-binding domain 1 protein
B4U37_RS12965	COG2339	peptidase activity
B4U37_RS12975	COG0492	ferredoxin-NADP+ reductase activity
B4U37_RS12980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U37_RS12985	COG4862	establishment of competence for transformation
B4U37_RS12990	COG0789	Transcriptional regulator
B4U37_RS12995	COG1408	metallophosphoesterase
B4U37_RS13010	COG1266	CAAX protease self-immunity
B4U37_RS13015	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_RS13020	COG4955	Helix-turn-helix domain
B4U37_RS13025	COG1141	Ferredoxin
B4U37_RS13030	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4U37_RS13035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U37_RS13045	COG0697	spore germination
B4U37_RS13050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS13060	COG2610	gluconate transmembrane transporter activity
B4U37_RS13070	COG1595	DNA-templated transcription, initiation
B4U37_RS13090	COG5002	protein histidine kinase activity
B4U37_RS13095	COG0745	RESPONSE REGULATOR receiver
B4U37_RS13100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U37_RS13105	COG1333	cytochrome c biogenesis protein
B4U37_RS13110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS13115	COG1187	pseudouridine synthase activity
B4U37_RS13120	COG0700	Nucleoside recognition
B4U37_RS13125	COG2715	membrane protein required for spore maturation
B4U37_RS13130	COG1686	Belongs to the peptidase S11 family
B4U37_RS13135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U37_RS13150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4U37_RS13155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4U37_RS13160	COG1547	Domain of unknown function (DUF309)
B4U37_RS13170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4U37_RS13175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U37_RS13175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U37_RS13180	COG0307	riboflavin synthase, alpha
B4U37_RS13185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U37_RS13185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U37_RS13190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U37_RS13215	COG0697	spore germination
B4U37_RS13230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_RS13255	COG2172	sigma factor antagonist activity
B4U37_RS13265	COG1686	Belongs to the peptidase S11 family
B4U37_RS13285	COG4974	Belongs to the 'phage' integrase family
B4U37_RS13295	COG0735	belongs to the Fur family
B4U37_RS13300	COG1300	Membrane
B4U37_RS13305	COG1379	DNA repair
B4U37_RS13310	COG0494	nUDIX hydrolase
B4U37_RS13320	COG0667	Aldo Keto reductase
B4U37_RS13335	COG0753	catalase activity
B4U37_RS13370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4U37_RS13385	COG0477	Major facilitator Superfamily
B4U37_RS13395	COG2217	Heavy metal translocating P-type atpase
B4U37_RS13425	COG3340	Belongs to the peptidase S51 family
B4U37_RS13445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U37_RS13450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U37_RS13455	COG0183	Belongs to the thiolase family
B4U37_RS13460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_RS13465	COG1742	UPF0060 membrane protein
B4U37_RS13520	COG1073	alpha beta
B4U37_RS13540	COG0778	Nitroreductase
B4U37_RS13545	COG3403	YqcI/YcgG family
B4U37_RS13550	COG1280	lysine exporter protein (LysE YggA)
B4U37_RS13570	COG0454	-acetyltransferase
B4U37_RS13575	COG2824	Alkylphosphonate utilization operon protein PhnA
B4U37_RS13585	COG1476	TRANSCRIPTIONal
B4U37_RS13620	COG2755	lipolytic protein G-D-S-L family
B4U37_RS13635	COG0577	efflux transmembrane transporter activity
B4U37_RS13640	COG1136	(ABC) transporter
B4U37_RS13645	COG5002	protein histidine kinase activity
B4U37_RS13650	COG0745	RESPONSE REGULATOR receiver
B4U37_RS13660	COG1193	negative regulation of DNA recombination
B4U37_RS13665	COG2323	membrane
B4U37_RS13680	COG0456	acetyltransferase
B4U37_RS13690	COG0681	Belongs to the peptidase S26 family
B4U37_RS13715	COG4555	ABC transporter
B4U37_RS13735	COG0534	Mate efflux family protein
B4U37_RS13750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS13755	COG0601	transmembrane transport
B4U37_RS13790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U37_RS13815	COG0300	oxidoreductase activity
B4U37_RS13820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS13825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_RS13840	COG4187	Peptidase family M20/M25/M40
B4U37_RS13845	COG1902	pentaerythritol trinitrate reductase activity
B4U37_RS13855	COG3615	Tellurite resistance protein tehB
B4U37_RS13855	COG0500	methyltransferase
B4U37_RS13885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U37_RS13890	COG1846	Transcriptional regulator
B4U37_RS13895	COG1764	response to oxidative stress
B4U37_RS13900	COG0835	chemotaxis
B4U37_RS13905	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U37_RS13915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U37_RS13920	COG0346	lactoylglutathione lyase activity
B4U37_RS13935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B4U37_RS13945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4U37_RS13950	COG1942	4-Oxalocrotonate Tautomerase
B4U37_RS13960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_RS13980	COG0251	oxidation-reduction process
B4U37_RS14000	COG2368	4-hydroxyphenylacetate
B4U37_RS14005	COG1376	ErfK ybiS ycfS ynhG family protein
B4U37_RS14010	COG4129	membrane
B4U37_RS14015	COG1164	Oligoendopeptidase f
B4U37_RS14025	COG1126	abc transporter atp-binding protein
B4U37_RS14030	COG0765	amino acid transport
B4U37_RS14035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U37_RS14045	COG1595	DNA-templated transcription, initiation
B4U37_RS14050	COG5002	protein histidine kinase activity
B4U37_RS14070	COG1703	isobutyryl-CoA mutase activity
B4U37_RS14075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_RS14075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_RS14080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_RS14095	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_RS14100	COG0022	dehydrogenase e1 component
B4U37_RS14105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U37_RS14110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_RS14115	COG3426	butyrate kinase activity
B4U37_RS14125	COG0280	phosphate acetyltransferase
B4U37_RS14130	COG3290	protein histidine kinase activity
B4U37_RS14130	COG3829	transcription factor binding
B4U37_RS14140	COG0584	glycerophosphoryl diester phosphodiesterase
B4U37_RS14145	COG3093	addiction module antidote protein HigA
B4U37_RS14150	COG0745	RESPONSE REGULATOR receiver
B4U37_RS14155	COG0750	zinc metalloprotease
B4U37_RS14160	COG0497	DNA recombination
B4U37_RS14165	COG1438	arginine binding
B4U37_RS14170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4U37_RS14175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4U37_RS14180	COG0142	geranyltranstransferase activity
B4U37_RS14185	COG1722	exodeoxyribonuclease VII activity
B4U37_RS14190	COG1570	exodeoxyribonuclease VII activity
B4U37_RS14195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U37_RS14205	COG1302	Protein conserved in bacteria
B4U37_RS14210	COG0439	Biotin carboxylase
B4U37_RS14215	COG0511	ligase activity, forming carbon-carbon bonds
B4U37_RS14260	COG3854	ATPases associated with a variety of cellular activities
B4U37_RS14270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_RS14275	COG0778	Nitroreductase
B4U37_RS14300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U37_RS14325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U37_RS14330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U37_RS14360	COG1051	belongs to the nudix hydrolase family
B4U37_RS14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U37_RS14430	COG1247	-acetyltransferase
B4U37_RS14510	COG5609	conserved protein (DUF2294)
B4U37_RS14520	COG2267	carboxylic ester hydrolase activity
B4U37_RS14530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U37_RS14535	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4U37_RS14540	COG1129	ABC transporter
B4U37_RS14555	COG0366	Alpha amylase catalytic
B4U37_RS14565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4U37_RS14570	COG0006	proline dipeptidase activity
B4U37_RS14575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4U37_RS14585	COG3872	metal-dependent enzyme
B4U37_RS14595	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U37_RS14600	COG1321	iron dependent repressor
B4U37_RS14620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_RS14630	COG0095	Lipoate-protein ligase
B4U37_RS14635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_RS14650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U37_RS14655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4U37_RS14660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U37_RS14685	COG2207	Transcriptional regulator
B4U37_RS14685	COG3708	Transcriptional regulator
B4U37_RS14705	COG2140	Oxalate decarboxylase
B4U37_RS14715	COG0681	Belongs to the peptidase S26 family
B4U37_RS14735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_RS14770	COG4970	Tfp pilus assembly protein FimT
B4U37_RS14775	COG4537	Required for transformation and DNA binding
B4U37_RS14785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4U37_RS14795	COG4608	Belongs to the ABC transporter superfamily
B4U37_RS14800	COG0791	NLP P60 protein
B4U37_RS14805	COG4948	Mandelate Racemase Muconate Lactonizing
B4U37_RS14810	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_RS14815	COG4166	transmembrane transport
B4U37_RS14820	COG0444	Belongs to the ABC transporter superfamily
B4U37_RS14825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_RS14830	COG0601	transmembrane transport
B4U37_RS14835	COG2362	D-Aminopeptidase
B4U37_RS14840	COG0693	protein deglycase activity
B4U37_RS14850	COG4191	Histidine kinase
B4U37_RS14885	COG1393	Belongs to the ArsC family
B4U37_RS14900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS14915	COG0011	TIGRFAM Protein of
B4U37_RS14930	COG1368	sulfuric ester hydrolase activity
B4U37_RS14935	COG1940	carbohydrate kinase activity
B4U37_RS14950	COG0697	spore germination
B4U37_RS14955	COG0457	Tetratricopeptide repeat
B4U37_RS14955	COG0705	Rhomboid family
B4U37_RS14960	COG0840	transmembrane signaling receptor activity
B4U37_RS14970	COG0039	L-malate dehydrogenase activity
B4U37_RS14980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4U37_RS14990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4U37_RS15030	COG0604	alcohol dehydrogenase
B4U37_RS15035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_RS15055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U37_RS15060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U37_RS15065	COG0640	Transcriptional regulator
B4U37_RS15070	COG0659	secondary active sulfate transmembrane transporter activity
B4U37_RS15075	COG0704	Plays a role in the regulation of phosphate uptake
B4U37_RS15080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U37_RS15085	COG0581	inorganic phosphate transmembrane transporter activity
B4U37_RS15090	COG0573	inorganic phosphate transmembrane transporter activity
B4U37_RS15095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U37_RS15100	COG0768	penicillin binding
B4U37_RS15105	COG0477	Major facilitator Superfamily
B4U37_RS15120	COG0205	6-phosphofructokinase activity
B4U37_RS15125	COG2839	Protein conserved in bacteria
B4U37_RS15130	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4U37_RS15145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4U37_RS15150	COG4709	membrane
B4U37_RS15155	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B4U37_RS15160	COG0735	belongs to the Fur family
B4U37_RS15165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_RS15170	COG1121	(ABC) transporter
B4U37_RS15175	COG5002	protein histidine kinase activity
B4U37_RS15185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4U37_RS15200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4U37_RS15205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4U37_RS15210	COG2384	SAM-dependent methyltransferase
B4U37_RS15215	COG2010	Cytochrome c
B4U37_RS15225	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS15235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U37_RS15240	COG0358	DNA primase activity
B4U37_RS15245	COG1671	Belongs to the UPF0178 family
B4U37_RS15255	COG0517	IMP dehydrogenase activity
B4U37_RS15260	COG0751	glycine-tRNA ligase activity
B4U37_RS15265	COG0752	glycyl-tRNA synthetase alpha subunit
B4U37_RS15270	COG1381	Involved in DNA repair and RecF pathway recombination
B4U37_RS15280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4U37_RS15285	COG0295	cytidine deaminase activity
B4U37_RS15290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4U37_RS15295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4U37_RS15300	COG1480	7TM receptor with intracellular HD hydrolase
B4U37_RS15305	COG1702	phosphate starvation-inducible protein PhoH
B4U37_RS15325	COG4864	UPF0365 protein
B4U37_RS15330	COG1030	water channel activity
B4U37_RS15335	COG1610	YqeY-like protein
B4U37_RS15350	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4U37_RS15355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U37_RS15360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U37_RS15365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4U37_RS15370	COG2264	protein methyltransferase activity
B4U37_RS15380	COG0443	Heat shock 70 kDa protein
B4U37_RS15385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U37_RS15390	COG1420	regulation of RNA biosynthetic process
B4U37_RS15395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U37_RS15400	COG0481	GTPase activity
B4U37_RS15410	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS15415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B4U37_RS15425	COG1466	dna polymerase III delta subunit
B4U37_RS15435	COG2333	competence protein COMEC
B4U37_RS15435	COG0658	competence protein
B4U37_RS15440	COG2131	deaminase
B4U37_RS15445	COG1555	photosystem II stabilization
B4U37_RS15445	COG1596	polysaccharide export
B4U37_RS15450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_RS15455	COG2226	methyltransferase
B4U37_RS15460	COG0799	negative regulation of ribosome biogenesis
B4U37_RS15465	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4U37_RS15470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4U37_RS15475	COG1534	Rna-binding protein
B4U37_RS15480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4U37_RS15485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4U37_RS15490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4U37_RS15500	COG0688	phosphatidylethanolamine metabolic process
B4U37_RS15530	COG1174	glycine betaine transport
B4U37_RS15535	COG1125	glycine betaine transport
B4U37_RS15535	COG0517	IMP dehydrogenase activity
B4U37_RS15540	COG1525	nuclease
B4U37_RS15550	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4U37_RS15555	COG0626	cystathionine gamma-synthase activity
B4U37_RS15560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_RS15565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U37_RS15570	COG2226	methyltransferase
B4U37_RS15590	COG0768	penicillin binding
B4U37_RS15595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4U37_RS15600	COG0572	uridine kinase
B4U37_RS15605	COG0826	peptidase U32
B4U37_RS15610	COG0826	peptidase U32
B4U37_RS15615	COG4122	O-methyltransferase activity
B4U37_RS15620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4U37_RS15625	COG1959	2 iron, 2 sulfur cluster binding
B4U37_RS15630	COG3906	Belongs to the UPF0473 family
B4U37_RS15635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4U37_RS15640	COG4472	Bacterial protein of unknown function (DUF965)
B4U37_RS15645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U37_RS15650	COG0628	permease
B4U37_RS15655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U37_RS15660	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_RS15665	COG3835	regulator
B4U37_RS15695	COG0493	'glutamate synthase
B4U37_RS15730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4U37_RS15740	COG0482	sulfurtransferase activity
B4U37_RS15745	COG1104	cysteine desulfurase activity
B4U37_RS15750	COG1959	2 iron, 2 sulfur cluster binding
B4U37_RS15755	COG2364	Membrane
B4U37_RS15760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4U37_RS15770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4U37_RS15785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4U37_RS15790	COG0124	histidyl-tRNA synthetase
B4U37_RS15800	COG4991	sh3 domain protein
B4U37_RS15800	COG3103	Sh3 type 3 domain protein
B4U37_RS15800	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS15805	COG1490	D-aminoacyl-tRNA deacylase activity
B4U37_RS15810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U37_RS15820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4U37_RS15820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U37_RS15825	COG5416	Lipopolysaccharide assembly protein A domain
B4U37_RS15830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U37_RS15835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U37_RS15835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U37_RS15845	COG2244	polysaccharide biosynthetic process
B4U37_RS15850	COG2323	membrane
B4U37_RS15860	COG1862	Preprotein translocase
B4U37_RS15865	COG0343	queuine tRNA-ribosyltransferase activity
B4U37_RS15870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4U37_RS15880	COG2255	four-way junction helicase activity
B4U37_RS15885	COG0632	four-way junction helicase activity
B4U37_RS15900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U37_RS15910	COG1388	LysM domain
B4U37_RS15920	COG0157	Belongs to the NadC ModD family
B4U37_RS15925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U37_RS15930	COG1104	cysteine desulfurase activity
B4U37_RS15935	COG1827	regulation of RNA biosynthetic process
B4U37_RS15940	COG0077	Prephenate dehydratase
B4U37_RS15945	COG4492	Belongs to the UPF0735 family
B4U37_RS15950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4U37_RS15955	COG3290	protein histidine kinase activity
B4U37_RS15965	COG2868	ribosomal protein
B4U37_RS15975	COG1530	ribonuclease E activity
B4U37_RS15980	COG1994	Peptidase M50
B4U37_RS15985	COG0739	heme binding
B4U37_RS16005	COG2894	cell division
B4U37_RS16010	COG0850	regulation of cytokinetic process
B4U37_RS16015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4U37_RS16020	COG1792	Involved in formation and maintenance of cell shape
B4U37_RS16025	COG1077	Cell shape determining protein MreB Mrl
B4U37_RS16030	COG2003	Belongs to the UPF0758 family
B4U37_RS16060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4U37_RS16070	COG1459	type II secretion system
B4U37_RS16080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4U37_RS16095	COG1595	DNA-templated transcription, initiation
B4U37_RS16110	COG0285	dihydrofolate synthase activity
B4U37_RS16125	COG0189	ligase activity
B4U37_RS16135	COG0285	dihydrofolate synthase activity
B4U37_RS16145	COG0525	valine-tRNA ligase activity
B4U37_RS16155	COG0840	transmembrane signaling receptor activity
B4U37_RS16160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U37_RS16165	COG1388	LysM domain
B4U37_RS16170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U37_RS16175	COG0113	porphobilinogen synthase activity
B4U37_RS16185	COG0181	hydroxymethylbilane synthase activity
B4U37_RS16190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U37_RS16205	COG1126	abc transporter atp-binding protein
B4U37_RS16210	COG0765	amino acid transport
B4U37_RS16215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U37_RS16220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U37_RS16225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4U37_RS16230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U37_RS16235	COG1067	ATP-dependent peptidase activity
B4U37_RS16235	COG0470	DNA polymerase III
B4U37_RS16245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4U37_RS16250	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4U37_RS16255	COG0457	Tetratricopeptide repeat
B4U37_RS16255	COG1477	protein flavinylation
B4U37_RS16270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4U37_RS16275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4U37_RS16280	COG5401	PFAM Sporulation and spore germination
B4U37_RS16290	COG2197	response regulator
B4U37_RS16295	COG0824	Thioesterase
B4U37_RS16300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U37_RS16305	COG1053	succinate dehydrogenase
B4U37_RS16310	COG2009	succinate dehydrogenase
B4U37_RS16315	COG1719	4-vinyl reductase, 4VR
B4U37_RS16330	COG0322	excinuclease ABC activity
B4U37_RS16335	COG3118	belongs to the thioredoxin family
B4U37_RS16345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U37_RS16350	COG2086	electron transfer activity
B4U37_RS16355	COG1024	Enoyl-CoA hydratase
B4U37_RS16360	COG1309	transcriptional regulator
B4U37_RS16365	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_RS16370	COG0475	glutathione-regulated potassium exporter activity
B4U37_RS16375	COG0490	domain, Protein
B4U37_RS16380	COG3766	membrane
B4U37_RS16390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_RS16390	COG1796	DNA polymerase
B4U37_RS16395	COG1286	toxin biosynthetic process
B4U37_RS16400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4U37_RS16405	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U37_RS16410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U37_RS16410	COG0072	phenylalanine-tRNA ligase activity
B4U37_RS16415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4U37_RS16420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U37_RS16435	COG1363	Peptidase, m42
B4U37_RS16465	COG1404	Belongs to the peptidase S8 family
B4U37_RS16480	COG0681	Belongs to the peptidase S26 family
B4U37_RS16490	COG1404	Belongs to the peptidase S8 family
B4U37_RS16495	COG1404	Belongs to the peptidase S8 family
B4U37_RS16500	COG1404	Belongs to the peptidase S8 family
B4U37_RS16505	COG1404	Belongs to the peptidase S8 family
B4U37_RS16510	COG0398	Pfam SNARE associated Golgi protein
B4U37_RS16515	COG3326	Membrane
B4U37_RS16525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4U37_RS16530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4U37_RS16535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U37_RS16545	COG1597	lipid kinase activity
B4U37_RS16550	COG3611	Membrane attachment protein
B4U37_RS16555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4U37_RS16565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4U37_RS16570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U37_RS16580	COG1971	Probably functions as a manganese efflux pump
B4U37_RS16590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U37_RS16595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_RS16595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_RS16600	COG0330	HflC and HflK could
B4U37_RS16610	COG5002	protein histidine kinase activity
B4U37_RS16615	COG0745	RESPONSE REGULATOR receiver
B4U37_RS16625	COG0039	L-malate dehydrogenase activity
B4U37_RS16630	COG0538	isocitrate dehydrogenase activity
B4U37_RS16635	COG0372	Belongs to the citrate synthase family
B4U37_RS16640	COG2707	UPF0756 membrane protein
B4U37_RS16645	COG0628	permease
B4U37_RS16665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U37_RS16705	COG4974	Belongs to the 'phage' integrase family
B4U37_RS16730	COG1131	(ABC) transporter
B4U37_RS16740	COG3344	reverse transcriptase
B4U37_RS16750	COG4086	secreted protein
B4U37_RS16755	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4U37_RS16765	COG0205	6-phosphofructokinase activity
B4U37_RS16770	COG0825	malonyl-CoA metabolic process
B4U37_RS16775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4U37_RS16780	COG2186	Transcriptional regulator
B4U37_RS16785	COG0281	malic enzyme
B4U37_RS16790	COG0587	DNA-directed DNA polymerase activity
B4U37_RS16805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U37_RS16820	COG4109	DRTGG domain
B4U37_RS16835	COG0006	proline dipeptidase activity
B4U37_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS16865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4U37_RS16870	COG0827	DNA restriction-modification system
B4U37_RS16875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4U37_RS16880	COG3874	Sporulation protein YtfJ
B4U37_RS16890	COG1714	RDD family
B4U37_RS16895	COG0616	signal peptide processing
B4U37_RS16900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U37_RS16905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4U37_RS16910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U37_RS16920	COG0301	tRNA thio-modification
B4U37_RS16925	COG1104	cysteine desulfurase activity
B4U37_RS16930	COG1114	Component of the transport system for branched-chain amino acids
B4U37_RS16940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4U37_RS16945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_RS16950	COG1309	transcriptional regulator
B4U37_RS16955	COG1956	GAF domain-containing protein
B4U37_RS16960	COG0626	cystathionine gamma-synthase activity
B4U37_RS16965	COG2203	Gaf domain
B4U37_RS16965	COG2199	diguanylate cyclase activity
B4U37_RS16975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4U37_RS16980	COG0456	acetyltransferase
B4U37_RS16985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U37_RS17000	COG2814	Major facilitator Superfamily
B4U37_RS17005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U37_RS17010	COG0454	-acetyltransferase
B4U37_RS17015	COG0517	IMP dehydrogenase activity
B4U37_RS17020	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4U37_RS17030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4U37_RS17040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4U37_RS17040	COG1605	Chorismate mutase
B4U37_RS17045	COG0849	cell division
B4U37_RS17050	COG3118	belongs to the thioredoxin family
B4U37_RS17055	COG4980	gas vesicle protein
B4U37_RS17060	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U37_RS17065	COG2309	aminopeptidase activity
B4U37_RS17070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4U37_RS17080	COG1674	ftsk spoiiie
B4U37_RS17080	COG1674	ftsk spoiiie
B4U37_RS17085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U37_RS17090	COG4848	Belongs to the UPF0354 family
B4U37_RS17095	COG1404	Belongs to the peptidase S8 family
B4U37_RS17095	COG4412	M6 family metalloprotease domain protein
B4U37_RS17100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS17110	COG0840	transmembrane signaling receptor activity
B4U37_RS17130	COG1363	Peptidase, m42
B4U37_RS17140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS17145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4U37_RS17155	COG0510	thiamine kinase activity
B4U37_RS17160	COG1523	belongs to the glycosyl hydrolase 13 family
B4U37_RS17170	COG1346	cytolysis
B4U37_RS17175	COG1380	Effector of murein hydrolase LrgA
B4U37_RS17185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_RS17195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U37_RS17205	COG1131	(ABC) transporter
B4U37_RS17210	COG1349	DNA-binding transcription factor activity
B4U37_RS17215	COG1187	pseudouridine synthase activity
B4U37_RS17220	COG2244	polysaccharide biosynthetic process
B4U37_RS17230	COG2081	HI0933 family
B4U37_RS17260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_RS17265	COG0495	leucyl-tRNA aminoacylation
B4U37_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS17280	COG2610	gluconate transmembrane transporter activity
B4U37_RS17285	COG3290	protein histidine kinase activity
B4U37_RS17285	COG3829	transcription factor binding
B4U37_RS17370	COG0326	Molecular chaperone. Has ATPase activity
B4U37_RS17375	COG2814	Major facilitator Superfamily
B4U37_RS17390	COG1242	4 iron, 4 sulfur cluster binding
B4U37_RS17395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4U37_RS17405	COG2267	carboxylic ester hydrolase activity
B4U37_RS17410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4U37_RS17415	COG0671	phosphoesterase, PA-phosphatase related
B4U37_RS17420	COG0438	transferase activity, transferring glycosyl groups
B4U37_RS17435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U37_RS17440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4U37_RS17445	COG1506	peptidase
B4U37_RS17450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4U37_RS17455	COG1116	anion transmembrane transporter activity
B4U37_RS17460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U37_RS17465	COG0494	nUDIX hydrolase
B4U37_RS17475	COG4824	toxin secretion phage lysis holin
B4U37_RS17485	COG0783	Belongs to the Dps family
B4U37_RS17500	COG0701	Predicted permease
B4U37_RS17510	COG1854	S-ribosylhomocysteine lyase activity
B4U37_RS17515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4U37_RS17520	COG0288	reversible hydration of carbon dioxide
B4U37_RS17525	COG0523	cobalamin synthesis protein
B4U37_RS17540	COG1271	oxidase subunit
B4U37_RS17545	COG1294	oxidase, subunit
B4U37_RS17560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_RS17565	COG1321	iron dependent repressor
B4U37_RS17565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_RS17570	COG1121	(ABC) transporter
B4U37_RS17575	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U37_RS17580	COG4948	Mandelate Racemase Muconate Lactonizing
B4U37_RS17590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4U37_RS17595	COG0596	Alpha beta hydrolase
B4U37_RS17600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4U37_RS17605	COG1169	isochorismate synthase
B4U37_RS17610	COG1575	Belongs to the MenA family. Type 1 subfamily
B4U37_RS17615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U37_RS17630	COG0058	SHG alpha-glucan phosphorylase activity
B4U37_RS17635	COG0297	glycogen (starch) synthase activity
B4U37_RS17640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4U37_RS17645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4U37_RS17780	COG3859	Proton-coupled thiamine transporter YuaJ
B4U37_RS17790	COG0697	spore germination
B4U37_RS17795	COG1285	pathogenesis
B4U37_RS17810	COG1215	transferase activity, transferring glycosyl groups
B4U37_RS17840	COG0489	protein tyrosine kinase activity
B4U37_RS17865	COG2197	response regulator
B4U37_RS17870	COG4585	Histidine kinase
B4U37_RS17880	COG1842	Phage shock protein A
B4U37_RS17895	COG1404	Belongs to the peptidase S8 family
B4U37_RS17905	COG2132	Multicopper oxidase
B4U37_RS17910	COG3314	Sporulation integral membrane protein YlbJ
B4U37_RS17915	COG0513	Belongs to the DEAD box helicase family
B4U37_RS17920	COG1408	metallophosphoesterase
B4U37_RS17925	COG2814	Major facilitator Superfamily
B4U37_RS17945	COG3279	Response regulator of the LytR AlgR family
B4U37_RS17950	COG2205	protein histidine kinase activity
B4U37_RS17955	COG3243	poly(R)-hydroxyalkanoic acid synthase
B4U37_RS17970	COG1278	Cold shock
B4U37_RS17995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U37_RS18015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U37_RS18015	COG2111	Na H antiporter
B4U37_RS18020	COG2111	Na H antiporter
B4U37_RS18025	COG1006	Multisubunit Na H antiporter MnhC subunit
B4U37_RS18030	COG0651	ATP synthesis coupled electron transport
B4U37_RS18035	COG1863	multisubunit Na H antiporter MnhE subunit
B4U37_RS18040	COG2212	antiporter activity
B4U37_RS18045	COG1320	monovalent cation:proton antiporter activity
B4U37_RS18050	COG1979	alcohol dehydrogenase
B4U37_RS18055	COG2155	Conserved Protein
B4U37_RS18060	COG1098	S1 RNA binding domain
B4U37_RS18070	COG0436	Aminotransferase
B4U37_RS18075	COG1522	sequence-specific DNA binding
B4U37_RS18080	COG2267	carboxylic ester hydrolase activity
B4U37_RS18090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4U37_RS18095	COG0588	phosphoglycerate mutase activity
B4U37_RS18100	COG2032	superoxide dismutase activity
B4U37_RS18110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U37_RS18120	COG5018	Exonuclease
B4U37_RS18125	COG2814	Major facilitator Superfamily
B4U37_RS18135	COG2050	protein possibly involved in aromatic compounds catabolism
B4U37_RS18140	COG0640	Transcriptional regulator
B4U37_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS18170	COG5520	Belongs to the glycosyl hydrolase 30 family
B4U37_RS18185	COG2723	6-phospho-beta-galactosidase activity
B4U37_RS18190	COG0395	ABC-type sugar transport system, permease component
B4U37_RS18205	COG1609	Transcriptional regulator
B4U37_RS18210	COG1131	(ABC) transporter
B4U37_RS18220	COG1595	DNA-templated transcription, initiation
B4U37_RS18230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B4U37_RS18235	COG0772	Belongs to the SEDS family
B4U37_RS18240	COG0772	Belongs to the SEDS family
B4U37_RS18250	COG1268	BioY protein
B4U37_RS18260	COG2056	Na+-H+ antiporter family
B4U37_RS18275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4U37_RS18280	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4U37_RS18285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_RS18290	COG3584	3D domain protein
B4U37_RS18305	COG1252	NADH dehydrogenase
B4U37_RS18320	COG0316	Belongs to the HesB IscA family
B4U37_RS18325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4U37_RS18330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U37_RS18340	COG4844	belongs to the
B4U37_RS18345	COG1252	NADH dehydrogenase
B4U37_RS18350	COG4837	Protein of unknown function (DUF1462)
B4U37_RS18355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4U37_RS18360	COG0083	homoserine kinase activity
B4U37_RS18365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4U37_RS18370	COG0460	homoserine dehydrogenase
B4U37_RS18375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_RS18380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U37_RS18385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U37_RS18390	COG0647	UMP catabolic process
B4U37_RS18395	COG2445	Protein of unknown function DUF86
B4U37_RS18400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B4U37_RS18415	COG4470	Protein conserved in bacteria
B4U37_RS18425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4U37_RS18430	COG0739	heme binding
B4U37_RS18440	COG0733	neurotransmitter:sodium symporter activity
B4U37_RS18445	COG1757	Na H antiporter
B4U37_RS18465	COG3377	Domain of unknown function (DUF1805)
B4U37_RS18470	COG0737	Belongs to the 5'-nucleotidase family
B4U37_RS18475	COG1801	Protein of unknown function DUF72
B4U37_RS18505	COG3655	Transcriptional regulator
B4U37_RS18510	COG3739	integral membrane protein
B4U37_RS18515	COG0719	Fe-S assembly protein
B4U37_RS18520	COG0822	iron-sulfur transferase activity
B4U37_RS18525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U37_RS18530	COG0719	Fe-S assembly protein
B4U37_RS18535	COG0396	ATPase activity
B4U37_RS18540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U37_RS18545	COG1464	Belongs to the NlpA lipoprotein family
B4U37_RS18550	COG2011	ABC-type metal ion transport system permease component
B4U37_RS18555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_RS18560	COG1597	lipid kinase activity
B4U37_RS18575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_RS18580	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U37_RS18590	COG0509	glycine decarboxylation via glycine cleavage system
B4U37_RS18595	COG1393	Belongs to the ArsC family
B4U37_RS18600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U37_RS18605	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS18610	COG0183	Belongs to the thiolase family
B4U37_RS18615	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_RS18615	COG1024	Enoyl-CoA hydratase
B4U37_RS18635	COG5577	PFAM Coat F domain
B4U37_RS18655	COG1120	ATPase activity
B4U37_RS18660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS18665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS18670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_RS18675	COG4085	toxin activity
B4U37_RS18675	COG1525	nuclease
B4U37_RS18675	COG0737	Belongs to the 5'-nucleotidase family
B4U37_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS18685	COG0750	zinc metalloprotease
B4U37_RS18690	COG0730	response to heat
B4U37_RS18695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_RS18695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_RS18700	COG0425	Belongs to the sulfur carrier protein TusA family
B4U37_RS18700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_RS18715	COG2210	Belongs to the sulfur carrier protein TusA family
B4U37_RS18720	COG0425	Belongs to the sulfur carrier protein TusA family
B4U37_RS18725	COG1937	Protein conserved in bacteria
B4U37_RS18745	COG0673	inositol 2-dehydrogenase activity
B4U37_RS18755	COG1609	Transcriptional regulator
B4U37_RS18760	COG0673	inositol 2-dehydrogenase activity
B4U37_RS18765	COG3459	Glycosyltransferase 36 associated
B4U37_RS18770	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U37_RS18775	COG0395	ABC-type sugar transport system, permease component
B4U37_RS18780	COG1175	transmembrane transport
B4U37_RS18795	COG0395	ABC-type sugar transport system, permease component
B4U37_RS18800	COG1175	transmembrane transport
B4U37_RS18830	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_RS18835	COG5002	protein histidine kinase activity
B4U37_RS18845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4U37_RS18850	COG0557	exoribonuclease II activity
B4U37_RS18855	COG1647	Serine aminopeptidase, S33
B4U37_RS18870	COG1396	sequence-specific DNA binding
B4U37_RS18880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U37_RS18885	COG0148	phosphopyruvate hydratase activity
B4U37_RS18890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4U37_RS18910	COG2390	Transcriptional regulator
B4U37_RS18920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4U37_RS18935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_RS18940	COG1481	regulation of sporulation
B4U37_RS18945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4U37_RS18950	COG1660	Displays ATPase and GTPase activities
B4U37_RS18955	COG1051	belongs to the nudix hydrolase family
B4U37_RS18960	COG0492	ferredoxin-NADP+ reductase activity
B4U37_RS18965	COG0457	Tetratricopeptide repeat
B4U37_RS18970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4U37_RS18970	COG0140	phosphoribosyl-ATP diphosphatase activity
B4U37_RS18975	COG0107	imidazoleglycerol-phosphate synthase activity
B4U37_RS18985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4U37_RS18990	COG0131	Imidazoleglycerol-phosphate dehydratase
B4U37_RS19000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4U37_RS19005	COG0110	maltose O-acetyltransferase activity
B4U37_RS19010	COG0546	phosphoglycolate phosphatase activity
B4U37_RS19015	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4U37_RS19025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4U37_RS19035	COG1950	PFAM Membrane protein of
B4U37_RS19045	COG3595	metallopeptidase activity
B4U37_RS19055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U37_RS19060	COG0556	nucleotide-excision repair
B4U37_RS19070	COG4897	Protein conserved in bacteria
B4U37_RS19080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B4U37_RS19100	COG1070	Carbohydrate kinase
B4U37_RS19105	COG2610	gluconate transmembrane transporter activity
B4U37_RS19110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U37_RS19115	COG1737	Transcriptional regulator
B4U37_RS19125	COG0586	Pfam SNARE associated Golgi protein
B4U37_RS19140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_RS19145	COG0793	Belongs to the peptidase S41A family
B4U37_RS19145	COG3409	Peptidoglycan-binding domain 1 protein
B4U37_RS19150	COG0739	heme binding
B4U37_RS19155	COG2177	Part of the ABC transporter FtsEX involved in
B4U37_RS19160	COG2884	Cell division ATP-binding protein ftsE
B4U37_RS19165	COG1404	Belongs to the peptidase S8 family
B4U37_RS19170	COG2010	Cytochrome c
B4U37_RS19175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_RS19185	COG0653	protein targeting
B4U37_RS19190	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS19190	COG2247	cell wall binding repeat
B4U37_RS19200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4U37_RS19215	COG1516	flagellar protein fliS
B4U37_RS19220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4U37_RS19225	COG1334	flagellar protein FlaG
B4U37_RS19260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U37_RS19265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4U37_RS19270	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B4U37_RS19280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U37_RS19285	COG4786	Flagellar basal body rod
B4U37_RS19285	COG1256	bacterial-type flagellum assembly
B4U37_RS19305	COG1040	competence protein
B4U37_RS19310	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4U37_RS19315	COG1307	EDD domain protein, DegV family
B4U37_RS19320	COG2197	response regulator
B4U37_RS19325	COG4585	Histidine kinase
B4U37_RS19330	COG1739	Uncharacterized protein family UPF0029
B4U37_RS19335	COG1316	TRANSCRIPTIONal
B4U37_RS19340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U37_RS19345	COG1215	transferase activity, transferring glycosyl groups
B4U37_RS19360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U37_RS19365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U37_RS19405	COG2385	sporulation resulting in formation of a cellular spore
B4U37_RS19405	COG2247	cell wall binding repeat
B4U37_RS19415	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS19445	COG0791	NLP P60 protein
B4U37_RS19445	COG1388	LysM domain
B4U37_RS19450	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS19450	COG2247	cell wall binding repeat
B4U37_RS19460	COG2385	sporulation resulting in formation of a cellular spore
B4U37_RS19460	COG2247	cell wall binding repeat
B4U37_RS19465	COG2340	Cysteine-rich secretory protein family
B4U37_RS19480	COG1134	teichoic acid transport
B4U37_RS19485	COG1682	transport, permease protein
B4U37_RS19490	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_RS19490	COG2918	glutathione biosynthetic process
B4U37_RS19495	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_RS19495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U37_RS19500	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_RS19500	COG2918	glutathione biosynthetic process
B4U37_RS19510	COG1215	transferase activity, transferring glycosyl groups
B4U37_RS19515	COG1215	transferase activity, transferring glycosyl groups
B4U37_RS19525	COG0438	transferase activity, transferring glycosyl groups
B4U37_RS19540	COG1316	TRANSCRIPTIONal
B4U37_RS19545	COG4464	protein tyrosine phosphatase activity
B4U37_RS19550	COG3764	Sortase (surface protein transpeptidase)
B4U37_RS19560	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS19575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U37_RS19610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U37_RS19620	COG1266	CAAX protease self-immunity
B4U37_RS19630	COG0745	RESPONSE REGULATOR receiver
B4U37_RS19635	COG2814	Major facilitator Superfamily
B4U37_RS19640	COG3344	reverse transcriptase
B4U37_RS19700	COG3764	Sortase (surface protein transpeptidase)
B4U37_RS19710	COG1405	negative regulation of cell septum assembly
B4U37_RS19710	COG3012	SEC-C Motif Domain Protein
B4U37_RS19735	COG0673	inositol 2-dehydrogenase activity
B4U37_RS19745	COG2972	Histidine kinase
B4U37_RS19770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U37_RS19780	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B4U37_RS19785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4U37_RS19795	COG0697	spore germination
B4U37_RS19800	COG1874	Beta-galactosidase
B4U37_RS19800	COG0366	Alpha amylase catalytic
B4U37_RS19810	COG0346	lactoylglutathione lyase activity
B4U37_RS19845	COG2962	Rard protein
B4U37_RS19860	COG0463	Glycosyl transferase, family 2
B4U37_RS19875	COG1595	DNA-templated transcription, initiation
B4U37_RS19900	COG0861	Integral membrane protein TerC family
B4U37_RS19905	COG0697	spore germination
B4U37_RS19910	COG0697	spore germination
B4U37_RS19915	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_RS19930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B4U37_RS19935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U37_RS19940	COG1309	transcriptional regulator
B4U37_RS19955	COG0861	Integral membrane protein TerC family
B4U37_RS19970	COG5444	nuclease activity
B4U37_RS19980	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_RS19980	COG2247	cell wall binding repeat
B4U37_RS19990	COG0464	growth
B4U37_RS20015	COG1609	Transcriptional regulator
B4U37_RS20035	COG0395	ABC-type sugar transport system, permease component
B4U37_RS20040	COG4209	transmembrane transport
B4U37_RS20045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U37_RS20105	COG0463	Glycosyl transferase, family 2
B4U37_RS20105	COG1216	Glycosyl transferase, family 2
B4U37_RS20110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U37_RS20130	COG0110	maltose O-acetyltransferase activity
B4U37_RS20135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4U37_RS20140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4U37_RS20150	COG1086	Polysaccharide biosynthesis protein
B4U37_RS20155	COG0489	protein tyrosine kinase activity
B4U37_RS20160	COG3944	biosynthesis protein
B4U37_RS20185	COG4786	Flagellar basal body rod
B4U37_RS20190	COG4786	Flagellar basal body rod
B4U37_RS20205	COG1077	Cell shape determining protein MreB Mrl
B4U37_RS20210	COG1609	Transcriptional regulator
B4U37_RS20225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4U37_RS20230	COG2176	DNA-directed DNA polymerase activity
B4U37_RS20230	COG5002	protein histidine kinase activity
B4U37_RS20240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_RS20260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U37_RS20265	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4U37_RS20270	COG2059	Chromate
B4U37_RS20275	COG2059	Chromate
B4U37_RS20280	COG0405	Gamma-glutamyltransferase
B4U37_RS20295	COG0739	heme binding
B4U37_RS20300	COG2385	sporulation resulting in formation of a cellular spore
B4U37_RS20305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U37_RS20315	COG4836	Membrane
B4U37_RS20320	COG1007	ATP synthesis coupled electron transport
B4U37_RS20325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_RS20330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U37_RS20335	COG0713	ATP synthesis coupled electron transport
B4U37_RS20340	COG0839	Belongs to the complex I subunit 6 family
B4U37_RS20360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_RS20365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_RS20380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U37_RS20385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4U37_RS20390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4U37_RS20395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_RS20405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_RS20430	COG1404	Belongs to the peptidase S8 family
B4U37_RS20435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4U37_RS20450	COG0698	ribose 5-phosphate isomerase
B4U37_RS20455	COG0840	transmembrane signaling receptor activity
B4U37_RS20465	COG1971	Probably functions as a manganese efflux pump
B4U37_RS20470	COG0009	L-threonylcarbamoyladenylate synthase
B4U37_RS20490	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U37_RS20495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4U37_RS20505	COG1435	thymidine kinase activity
B4U37_RS20515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4U37_RS20525	COG1494	fructose-1,6-bisphosphatase
B4U37_RS20530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U37_RS20535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U37_RS20540	COG0191	fructose-bisphosphate aldolase activity
B4U37_RS20545	COG2204	response regulator
B4U37_RS20550	COG4821	SIS domain
B4U37_RS20565	COG0504	CTP synthase activity
B4U37_RS20570	COG3343	RNA polymerase activity
B4U37_RS20575	COG1703	isobutyryl-CoA mutase activity
B4U37_RS20575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_RS20575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_RS20580	COG3226	Transcriptional regulator
B4U37_RS20585	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS20590	COG1960	acyl-CoA dehydrogenase activity
B4U37_RS20595	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_RS20600	COG0183	Belongs to the thiolase family
B4U37_RS20605	COG0247	lactate metabolic process
B4U37_RS20605	COG2181	nitrate reductase activity
B4U37_RS20610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U37_RS20615	COG4294	response to UV
B4U37_RS20625	COG0018	arginyl-trna synthetase
B4U37_RS20635	COG0010	Belongs to the arginase family
B4U37_RS20640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4U37_RS20645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_RS20665	COG3465	dGTPase activity
B4U37_RS20670	COG1078	dGTPase activity
B4U37_RS20675	COG4844	belongs to the
B4U37_RS20690	COG0280	phosphate acetyltransferase
B4U37_RS20695	COG3253	May function as heme-dependent peroxidase
B4U37_RS20705	COG2363	Small membrane protein
B4U37_RS20720	COG2322	membrane
B4U37_RS20730	COG0840	transmembrane signaling receptor activity
B4U37_RS20740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U37_RS20745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U37_RS20750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B4U37_RS20755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U37_RS20770	COG2261	transglycosylase associated protein
B4U37_RS20785	COG0778	Nitroreductase
B4U37_RS20795	COG1511	domain protein
B4U37_RS20795	COG0842	Transport permease protein
B4U37_RS20800	COG1131	(ABC) transporter
B4U37_RS20805	COG2031	fatty acid transporter
B4U37_RS20820	COG1621	beta-fructofuranosidase activity
B4U37_RS20825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U37_RS20830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_RS20830	COG1263	PTS System
B4U37_RS20835	COG3711	transcriptional antiterminator
B4U37_RS20840	COG2190	(PTS) system
B4U37_RS20845	COG3153	acetyltransferase
B4U37_RS20845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_RS20855	COG0561	phosphatase activity
B4U37_RS20865	COG3314	Sporulation integral membrane protein YlbJ
B4U37_RS20885	COG2190	(PTS) system
B4U37_RS20885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_RS20885	COG1263	PTS System
B4U37_RS20900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_RS20900	COG0551	DNA topoisomerase type I activity
B4U37_RS20905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_RS20910	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U37_RS20915	COG0488	(ABC) transporter
B4U37_RS20920	COG3546	catalase activity
B4U37_RS20945	COG2205	protein histidine kinase activity
B4U37_RS20950	COG0745	RESPONSE REGULATOR receiver
B4U37_RS20960	COG1131	(ABC) transporter
B4U37_RS20965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4U37_RS20985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U37_RS21000	COG2267	carboxylic ester hydrolase activity
B4U37_RS21015	COG3321	synthase
B4U37_RS21015	COG0604	alcohol dehydrogenase
B4U37_RS21030	COG0753	catalase activity
B4U37_RS21040	COG1175	transmembrane transport
B4U37_RS21045	COG1653	transport
B4U37_RS21050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U37_RS21055	COG1737	Transcriptional regulator
B4U37_RS21075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U37_RS21080	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B4U37_RS21090	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B4U37_RS21095	COG0698	ribose 5-phosphate isomerase
B4U37_RS21100	COG0149	triose-phosphate isomerase activity
B4U37_RS21125	COG4869	propanediol catabolic process
B4U37_RS21130	COG2390	Transcriptional regulator
B4U37_RS21135	COG1079	Belongs to the binding-protein-dependent transport system permease family
B4U37_RS21140	COG4603	Belongs to the binding-protein-dependent transport system permease family
B4U37_RS21145	COG3845	ABC transporter
B4U37_RS21155	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U37_RS21160	COG1187	pseudouridine synthase activity
B4U37_RS21165	COG3842	ATPase activity
B4U37_RS21170	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4U37_RS21180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4U37_RS21185	COG0745	RESPONSE REGULATOR receiver
B4U37_RS21190	COG2205	protein histidine kinase activity
B4U37_RS21195	COG1136	(ABC) transporter
B4U37_RS21200	COG0577	efflux transmembrane transporter activity
B4U37_RS21205	COG1120	ATPase activity
B4U37_RS21210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U37_RS21215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS21220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_RS21255	COG2358	TRAP transporter, solute receptor (TAXI family
B4U37_RS21275	COG1984	allophanate hydrolase subunit 2
B4U37_RS21280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4U37_RS21285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U37_RS21290	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U37_RS21295	COG1307	EDD domain protein, DegV family
B4U37_RS21310	COG0579	oxidoreductase
B4U37_RS21315	COG4682	membrane
B4U37_RS21340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U37_RS21345	COG3706	GGDEF domain
B4U37_RS21350	COG0697	spore germination
B4U37_RS21400	COG2011	ABC-type metal ion transport system permease component
B4U37_RS21405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_RS21415	COG0371	Dehydrogenase
B4U37_RS21435	COG2814	Major facilitator Superfamily
B4U37_RS21450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_RS21455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4U37_RS21460	COG4853	Protein conserved in bacteria
B4U37_RS21470	COG5002	protein histidine kinase activity
B4U37_RS21475	COG0745	RESPONSE REGULATOR receiver
B4U37_RS21480	COG1196	nuclear chromosome segregation
B4U37_RS21480	COG0741	lytic transglycosylase activity
B4U37_RS21480	COG0739	heme binding
B4U37_RS21505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B4U37_RS21510	COG0305	Participates in initiation and elongation during chromosome replication
B4U37_RS21515	COG0359	binds to the 23S rRNA
B4U37_RS21520	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4U37_RS21525	COG4241	membrane
B4U37_RS21530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4U37_RS21535	COG0629	single-stranded DNA binding
B4U37_RS21540	COG0360	Binds together with S18 to 16S ribosomal RNA
B4U37_RS21545	COG0012	GTP binding
B4U37_RS21550	COG4481	Protein conserved in bacteria
B4U37_RS21555	COG0668	transmembrane transport
B4U37_RS21560	COG3949	Membrane
B4U37_RS21570	COG1811	Na channel or pump
B4U37_RS21575	COG1475	DNA binding
B4U37_RS21580	COG1192	Involved in chromosome partitioning
B4U37_RS21585	COG1475	DNA binding
B4U37_RS21595	COG0445	tRNA wobble uridine modification
B4U37_RS21600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4U37_RS21605	COG1847	R3H domain protein
B4U37_RS21650	COG1131	(ABC) transporter
B4U37_RS21660	COG3279	Response regulator of the LytR AlgR family
B4U37_RS21690	COG1192	Involved in chromosome partitioning