locus-tag	class	description
BIS30_RS00030	COG4974	Belongs to the 'phage' integrase family
BIS30_RS00045	COG2273	Hydrolase Family 16
BIS30_RS00050	COG4282	regulation of fungal-type cell wall biogenesis
BIS30_RS00055	COG1231	oxidoreductase activity
BIS30_RS00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_RS00065	COG0662	Cupin 2, conserved barrel domain protein
BIS30_RS00065	COG2207	Transcriptional regulator
BIS30_RS00070	COG0456	acetyltransferase
BIS30_RS00080	COG1309	transcriptional regulator
BIS30_RS00090	COG3708	Transcriptional regulator
BIS30_RS00095	COG2378	regulation of single-species biofilm formation
BIS30_RS00105	COG0640	Transcriptional regulator
BIS30_RS00110	COG0741	lytic transglycosylase activity
BIS30_RS00115	COG2322	membrane
BIS30_RS00130	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIS30_RS00135	COG3239	Fatty acid desaturase
BIS30_RS00140	COG4585	Histidine kinase
BIS30_RS00145	COG2197	response regulator
BIS30_RS00150	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS00155	COG1388	LysM domain
BIS30_RS00155	COG3584	3D domain protein
BIS30_RS00160	COG0514	ATP-dependent DNA helicase (RecQ)
BIS30_RS00165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIS30_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS00190	COG1657	PFAM Prenyltransferase squalene oxidase
BIS30_RS00195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIS30_RS00200	COG0733	neurotransmitter:sodium symporter activity
BIS30_RS00205	COG0385	Bile acid
BIS30_RS00210	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_RS00215	COG0567	Dehydrogenase, E1 component
BIS30_RS00220	COG4548	von Willebrand factor, type A
BIS30_RS00225	COG0714	Associated with various cellular activities
BIS30_RS00230	COG2032	superoxide dismutase activity
BIS30_RS00235	COG0791	NLP P60 protein
BIS30_RS00235	COG1388	LysM domain
BIS30_RS00240	COG1819	glycosyl
BIS30_RS00245	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIS30_RS00250	COG0534	Mate efflux family protein
BIS30_RS00255	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS00260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_RS00265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_RS00275	COG2962	Rard protein
BIS30_RS00290	COG1942	4-Oxalocrotonate Tautomerase
BIS30_RS00295	COG1733	regulation of RNA biosynthetic process
BIS30_RS00300	COG0778	Nitroreductase
BIS30_RS00305	COG0400	carboxylic ester hydrolase activity
BIS30_RS00320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS00325	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS00325	COG0793	Belongs to the peptidase S41A family
BIS30_RS00330	COG2226	methyltransferase
BIS30_RS00340	COG1876	peptidase activity
BIS30_RS00345	COG0813	purine-nucleoside phosphorylase activity
BIS30_RS00360	COG0671	phosphoesterase, PA-phosphatase related
BIS30_RS00380	COG4479	Belongs to the UPF0346 family
BIS30_RS00390	COG1509	lysine 2,3-aminomutase activity
BIS30_RS00395	COG0456	acetyltransferase
BIS30_RS00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_RS00405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BIS30_RS00410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BIS30_RS00430	COG0456	acetyltransferase
BIS30_RS00450	COG4641	Protein conserved in bacteria
BIS30_RS00455	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BIS30_RS00460	COG1086	Polysaccharide biosynthesis protein
BIS30_RS00465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIS30_RS00470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIS30_RS00475	COG1846	Transcriptional regulator
BIS30_RS00480	COG0534	Mate efflux family protein
BIS30_RS00490	COG4698	Protein conserved in bacteria
BIS30_RS00495	COG2755	lipolytic protein G-D-S-L family
BIS30_RS00500	COG1999	signal sequence binding
BIS30_RS00515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIS30_RS00520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIS30_RS00525	COG1272	protein, Hemolysin III
BIS30_RS00530	COG0204	Acyl-transferase
BIS30_RS00535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIS30_RS00545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIS30_RS00555	COG2136	Putative SAM-dependent methyltransferase
BIS30_RS00555	COG2521	methyltransferase
BIS30_RS00565	COG0129	dihydroxy-acid dehydratase activity
BIS30_RS00570	COG1413	lyase activity
BIS30_RS00575	COG1418	mRNA catabolic process
BIS30_RS00580	COG0386	Belongs to the glutathione peroxidase family
BIS30_RS00585	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BIS30_RS00590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_RS00595	COG1278	Cold shock
BIS30_RS00615	COG0328	RNA-DNA hybrid ribonuclease activity
BIS30_RS00620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BIS30_RS00625	COG0328	RNA-DNA hybrid ribonuclease activity
BIS30_RS00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_RS00655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIS30_RS00660	COG1755	Isoprenylcysteine carboxyl methyltransferase
BIS30_RS00665	COG3424	synthase
BIS30_RS00670	COG2233	PERMEase
BIS30_RS00675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_RS00680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BIS30_RS00690	COG0800	Aldolase
BIS30_RS00700	COG1609	Transcriptional regulator
BIS30_RS00705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BIS30_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS00715	COG1199	ATP-dependent helicase activity
BIS30_RS00725	COG0116	Belongs to the methyltransferase superfamily
BIS30_RS00735	COG4474	Belongs to the UPF0398 family
BIS30_RS00750	COG3359	exonuclease
BIS30_RS00755	COG1205	dead DEAH box helicase
BIS30_RS00755	COG1111	helicase
BIS30_RS00760	COG2190	(PTS) system
BIS30_RS00765	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_RS00800	COG3331	DNA recombination
BIS30_RS00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_RS00805	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIS30_RS00815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIS30_RS00820	COG3935	DnaD domain protein
BIS30_RS00825	COG0017	Asparaginyl-tRNA synthetase
BIS30_RS00830	COG0436	Aminotransferase
BIS30_RS00835	COG5353	protein conserved in bacteria
BIS30_RS00845	COG1199	ATP-dependent helicase activity
BIS30_RS00845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIS30_RS00850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIS30_RS00855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIS30_RS00860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BIS30_RS00870	COG0617	tRNA 3'-terminal CCA addition
BIS30_RS00875	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS00880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_RS00885	COG1803	Methylglyoxal synthase
BIS30_RS00890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIS30_RS00895	COG1694	Mazg nucleotide pyrophosphohydrolase
BIS30_RS00900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS00910	COG4347	Protein of unknown function (DUF1405)
BIS30_RS00915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIS30_RS00915	COG2010	Cytochrome c
BIS30_RS00920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIS30_RS00925	COG0723	plastoquinol--plastocyanin reductase activity
BIS30_RS00935	COG5582	Belongs to the UPF0302 family
BIS30_RS00940	COG0457	Tetratricopeptide repeat
BIS30_RS00945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIS30_RS00950	COG0287	Prephenate dehydrogenase
BIS30_RS00955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIS30_RS00960	COG0159	tryptophan synthase activity
BIS30_RS00965	COG0133	tryptophan synthase activity
BIS30_RS00970	COG0135	phosphoribosylanthranilate isomerase activity
BIS30_RS00980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIS30_RS00985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIS30_RS00990	COG4401	Chorismate mutase type I
BIS30_RS00995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIS30_RS01000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIS30_RS01005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIS30_RS01015	COG0105	UTP biosynthetic process
BIS30_RS01020	COG0142	geranyltranstransferase activity
BIS30_RS01025	COG2226	methyltransferase
BIS30_RS01030	COG0142	geranyltranstransferase activity
BIS30_RS01040	COG0302	gtp cyclohydrolase
BIS30_RS01045	COG0776	regulation of translation
BIS30_RS01050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIS30_RS01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BIS30_RS01070	COG1160	GTP binding
BIS30_RS01095	COG1304	FMN binding
BIS30_RS01100	COG0539	negative regulation of cytoplasmic translation
BIS30_RS01105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIS30_RS01115	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BIS30_RS01120	COG2959	enzyme of heme biosynthesis
BIS30_RS01125	COG3773	Cell wall hydrolase
BIS30_RS01125	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS01130	COG2339	peptidase activity
BIS30_RS01135	COG0492	ferredoxin-NADP+ reductase activity
BIS30_RS01140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_RS01145	COG4862	establishment of competence for transformation
BIS30_RS01150	COG1408	metallophosphoesterase
BIS30_RS01160	COG1388	LysM domain
BIS30_RS01165	COG1266	CAAX protease self-immunity
BIS30_RS01170	COG0514	ATP-dependent DNA helicase (RecQ)
BIS30_RS01175	COG4955	Helix-turn-helix domain
BIS30_RS01180	COG1141	Ferredoxin
BIS30_RS01185	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIS30_RS01195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIS30_RS01200	COG0710	3-dehydroquinate dehydratase activity
BIS30_RS01210	COG1595	DNA-templated transcription, initiation
BIS30_RS01215	COG5002	protein histidine kinase activity
BIS30_RS01220	COG0745	RESPONSE REGULATOR receiver
BIS30_RS01225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIS30_RS01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS01240	COG1187	pseudouridine synthase activity
BIS30_RS01245	COG0700	Nucleoside recognition
BIS30_RS01250	COG2715	membrane protein required for spore maturation
BIS30_RS01255	COG1686	Belongs to the peptidase S11 family
BIS30_RS01265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIS30_RS01270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIS30_RS01275	COG1547	Domain of unknown function (DUF309)
BIS30_RS01280	COG0456	acetyltransferase
BIS30_RS01285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIS30_RS01290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIS30_RS01290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIS30_RS01295	COG0307	riboflavin synthase, alpha
BIS30_RS01300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIS30_RS01300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIS30_RS01310	COG0681	Belongs to the peptidase S26 family
BIS30_RS01315	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BIS30_RS01325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIS30_RS01335	COG4086	secreted protein
BIS30_RS01340	COG0019	diaminopimelate decarboxylase activity
BIS30_RS01345	COG0697	spore germination
BIS30_RS01360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIS30_RS01380	COG1191	sigma factor activity
BIS30_RS01385	COG2172	sigma factor antagonist activity
BIS30_RS01390	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS01395	COG1686	Belongs to the peptidase S11 family
BIS30_RS01400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BIS30_RS01405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BIS30_RS01410	COG4974	Belongs to the 'phage' integrase family
BIS30_RS01420	COG0735	belongs to the Fur family
BIS30_RS01425	COG1300	Membrane
BIS30_RS01435	COG0281	malic enzyme
BIS30_RS01440	COG1757	Na H antiporter
BIS30_RS01445	COG1027	Aspartate ammonia-lyase
BIS30_RS01450	COG0252	asparaginase activity
BIS30_RS01455	COG1396	sequence-specific DNA binding
BIS30_RS01475	COG0494	nUDIX hydrolase
BIS30_RS01495	COG1073	alpha beta
BIS30_RS01500	COG0772	Belongs to the SEDS family
BIS30_RS01505	COG0772	Belongs to the SEDS family
BIS30_RS01510	COG3339	Conserved Protein
BIS30_RS01520	COG4918	Iron-sulphur cluster biosynthesis
BIS30_RS01525	COG0456	acetyltransferase
BIS30_RS01525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BIS30_RS01530	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_RS01535	COG0456	acetyltransferase
BIS30_RS01545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIS30_RS01560	COG2211	Major facilitator Superfamily
BIS30_RS01570	COG0346	lactoylglutathione lyase activity
BIS30_RS01575	COG1072	(Pantothenic acid kinase))
BIS30_RS01580	COG3048	D-serine ammonia-lyase activity
BIS30_RS01585	COG0300	oxidoreductase activity
BIS30_RS01590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS01595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_RS01600	COG4187	Peptidase family M20/M25/M40
BIS30_RS01605	COG1902	pentaerythritol trinitrate reductase activity
BIS30_RS01610	COG0596	Alpha beta hydrolase
BIS30_RS01630	COG1234	tRNA 3'-trailer cleavage
BIS30_RS01635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIS30_RS01640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIS30_RS01645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIS30_RS01655	COG0706	membrane insertase activity
BIS30_RS01660	COG3361	conserved protein (COG2071)
BIS30_RS01665	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIS30_RS01675	COG0346	lactoylglutathione lyase activity
BIS30_RS01685	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_RS01690	COG4129	membrane
BIS30_RS01695	COG1126	abc transporter atp-binding protein
BIS30_RS01700	COG0765	amino acid transport
BIS30_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_RS01715	COG1597	lipid kinase activity
BIS30_RS01720	COG2814	Major facilitator Superfamily
BIS30_RS01725	COG4978	Transcriptional regulator
BIS30_RS01725	COG0789	Transcriptional regulator
BIS30_RS01730	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_RS01735	COG0022	dehydrogenase e1 component
BIS30_RS01740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_RS01745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_RS01750	COG3426	butyrate kinase activity
BIS30_RS01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_RS01760	COG0280	phosphate acetyltransferase
BIS30_RS01765	COG3290	protein histidine kinase activity
BIS30_RS01765	COG3829	transcription factor binding
BIS30_RS01775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BIS30_RS01780	COG2079	MmgE PrpD family protein
BIS30_RS01785	COG0372	Belongs to the citrate synthase family
BIS30_RS01790	COG1960	acyl-CoA dehydrogenase activity
BIS30_RS01795	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIS30_RS01800	COG0183	Belongs to the thiolase family
BIS30_RS01805	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_RS01810	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS01825	COG1902	pentaerythritol trinitrate reductase activity
BIS30_RS01835	COG0745	RESPONSE REGULATOR receiver
BIS30_RS01845	COG0750	zinc metalloprotease
BIS30_RS01850	COG0497	DNA recombination
BIS30_RS01855	COG1438	arginine binding
BIS30_RS01860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BIS30_RS01865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIS30_RS01870	COG0142	geranyltranstransferase activity
BIS30_RS01875	COG1722	exodeoxyribonuclease VII activity
BIS30_RS01880	COG1570	exodeoxyribonuclease VII activity
BIS30_RS01890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIS30_RS01895	COG1302	Protein conserved in bacteria
BIS30_RS01905	COG0511	ligase activity, forming carbon-carbon bonds
BIS30_RS01945	COG3854	ATPases associated with a variety of cellular activities
BIS30_RS01955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIS30_RS01960	COG0006	proline dipeptidase activity
BIS30_RS01965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIS30_RS01975	COG3872	metal-dependent enzyme
BIS30_RS01985	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIS30_RS01990	COG1321	iron dependent repressor
BIS30_RS01995	COG0095	Lipoate-protein ligase
BIS30_RS02000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIS30_RS02005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIS30_RS02010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIS30_RS02015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BIS30_RS02020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIS30_RS02035	COG1396	sequence-specific DNA binding
BIS30_RS02045	COG0681	Belongs to the peptidase S26 family
BIS30_RS02070	COG4940	Competence protein ComGF
BIS30_RS02080	COG4970	Tfp pilus assembly protein FimT
BIS30_RS02085	COG4537	Required for transformation and DNA binding
BIS30_RS02090	COG1459	type II secretion system
BIS30_RS02095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIS30_RS02100	COG0517	IMP dehydrogenase activity
BIS30_RS02105	COG0598	Magnesium transport protein CorA
BIS30_RS02115	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS02125	COG1393	Belongs to the ArsC family
BIS30_RS02135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS02145	COG0011	TIGRFAM Protein of
BIS30_RS02155	COG2866	Carboxypeptidase
BIS30_RS02160	COG1368	sulfuric ester hydrolase activity
BIS30_RS02165	COG1940	carbohydrate kinase activity
BIS30_RS02170	COG4483	Protein conserved in bacteria
BIS30_RS02175	COG0705	Rhomboid family
BIS30_RS02175	COG0457	Tetratricopeptide repeat
BIS30_RS02185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIS30_RS02195	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS02210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIS30_RS02215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_RS02220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_RS02225	COG0581	inorganic phosphate transmembrane transporter activity
BIS30_RS02230	COG0573	inorganic phosphate transmembrane transporter activity
BIS30_RS02235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIS30_RS02240	COG0768	penicillin binding
BIS30_RS02245	COG0477	Major facilitator Superfamily
BIS30_RS02250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIS30_RS02255	COG2839	Protein conserved in bacteria
BIS30_RS02260	COG5521	maltodextrose utilization protein MalA
BIS30_RS02265	COG1388	LysM domain
BIS30_RS02275	COG4709	membrane
BIS30_RS02280	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BIS30_RS02285	COG0735	belongs to the Fur family
BIS30_RS02290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS02300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIS30_RS02305	COG0513	Belongs to the DEAD box helicase family
BIS30_RS02315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIS30_RS02320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIS30_RS02325	COG2384	SAM-dependent methyltransferase
BIS30_RS02330	COG2010	Cytochrome c
BIS30_RS02335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIS30_RS02340	COG0358	DNA primase activity
BIS30_RS02345	COG1671	Belongs to the UPF0178 family
BIS30_RS02350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIS30_RS02355	COG0517	IMP dehydrogenase activity
BIS30_RS02360	COG0751	glycine-tRNA ligase activity
BIS30_RS02365	COG0752	glycyl-tRNA synthetase alpha subunit
BIS30_RS02370	COG1381	Involved in DNA repair and RecF pathway recombination
BIS30_RS02380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIS30_RS02385	COG0295	cytidine deaminase activity
BIS30_RS02390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIS30_RS02395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIS30_RS02400	COG1480	7TM receptor with intracellular HD hydrolase
BIS30_RS02410	COG1702	phosphate starvation-inducible protein PhoH
BIS30_RS02415	COG0561	phosphatase activity
BIS30_RS02430	COG4864	UPF0365 protein
BIS30_RS02435	COG1030	water channel activity
BIS30_RS02440	COG1610	YqeY-like protein
BIS30_RS02450	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIS30_RS02455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIS30_RS02460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIS30_RS02465	COG2264	protein methyltransferase activity
BIS30_RS02470	COG0484	heat shock protein binding
BIS30_RS02480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIS30_RS02485	COG1420	regulation of RNA biosynthetic process
BIS30_RS02490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIS30_RS02495	COG0481	GTPase activity
BIS30_RS02505	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS02510	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BIS30_RS02515	COG0268	Binds directly to 16S ribosomal RNA
BIS30_RS02520	COG1466	dna polymerase III delta subunit
BIS30_RS02530	COG0658	competence protein
BIS30_RS02530	COG2333	competence protein COMEC
BIS30_RS02535	COG2131	deaminase
BIS30_RS02540	COG1555	photosystem II stabilization
BIS30_RS02540	COG1596	polysaccharide export
BIS30_RS02545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_RS02550	COG2226	methyltransferase
BIS30_RS02555	COG0799	negative regulation of ribosome biogenesis
BIS30_RS02560	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIS30_RS02565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIS30_RS02570	COG1534	Rna-binding protein
BIS30_RS02575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIS30_RS02580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIS30_RS02585	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BIS30_RS02600	COG2755	lipolytic protein G-D-S-L family
BIS30_RS02610	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS02610	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS02615	COG0398	Pfam SNARE associated Golgi protein
BIS30_RS02620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIS30_RS02630	COG3209	COG3209 Rhs family protein
BIS30_RS02640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIS30_RS02645	COG0114	fumarate hydratase activity
BIS30_RS02650	COG0583	DNA-binding transcription factor activity
BIS30_RS02670	COG2070	2-Nitropropane dioxygenase
BIS30_RS02675	COG1846	Transcriptional regulator
BIS30_RS02685	COG1733	regulation of RNA biosynthetic process
BIS30_RS02695	COG2207	Transcriptional regulator
BIS30_RS02705	COG4221	oxidoreductase activity
BIS30_RS02710	COG0456	acetyltransferase
BIS30_RS02715	COG0789	Transcriptional regulator
BIS30_RS02715	COG4978	Transcriptional regulator
BIS30_RS02720	COG2814	Major facilitator Superfamily
BIS30_RS02725	COG1183	phosphatidylcholine synthase activity
BIS30_RS02735	COG2186	Transcriptional regulator
BIS30_RS02740	COG0205	6-phosphofructokinase activity
BIS30_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS02755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIS30_RS02760	COG3959	Transketolase, thiamine diphosphate binding domain
BIS30_RS02775	COG0640	Transcriptional regulator
BIS30_RS02785	COG2315	Protein conserved in bacteria
BIS30_RS02800	COG3443	Belongs to the bacterial solute-binding protein 9 family
BIS30_RS02805	COG4991	sh3 domain protein
BIS30_RS02810	COG4991	sh3 domain protein
BIS30_RS02820	COG5577	PFAM Coat F domain
BIS30_RS02825	COG1063	alcohol dehydrogenase
BIS30_RS02835	COG5577	PFAM Coat F domain
BIS30_RS02845	COG0667	Aldo Keto reductase
BIS30_RS02850	COG2207	Transcriptional regulator
BIS30_RS02855	COG0789	Transcriptional regulator
BIS30_RS02860	COG0789	Transcriptional regulator
BIS30_RS02870	COG1064	alcohol dehydrogenase
BIS30_RS02875	COG0693	protein deglycase activity
BIS30_RS02880	COG1621	beta-fructofuranosidase activity
BIS30_RS02885	COG3716	PTS system mannose fructose sorbose family IID component
BIS30_RS02890	COG3715	PTS system
BIS30_RS02895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS02900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS02905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIS30_RS02905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIS30_RS02920	COG1113	amino acid transport
BIS30_RS02925	COG1280	lysine exporter protein (LysE YggA)
BIS30_RS02930	COG1378	Sugar-specific transcriptional regulator TrmB
BIS30_RS02935	COG1595	DNA-templated transcription, initiation
BIS30_RS02945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIS30_RS02945	COG2755	lipolytic protein G-D-S-L family
BIS30_RS02955	COG2124	cytochrome p450
BIS30_RS02955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_RS02960	COG1309	transcriptional regulator
BIS30_RS02965	COG2226	methyltransferase
BIS30_RS02985	COG2116	formate transmembrane transporter activity
BIS30_RS02990	COG5609	conserved protein (DUF2294)
BIS30_RS02995	COG3383	formate dehydrogenase (NAD+) activity
BIS30_RS03000	COG2427	Protein of unknown function (DUF1641)
BIS30_RS03010	COG0626	cystathionine gamma-synthase activity
BIS30_RS03015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_RS03020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIS30_RS03025	COG2226	methyltransferase
BIS30_RS03040	COG0768	penicillin binding
BIS30_RS03045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIS30_RS03050	COG0572	uridine kinase
BIS30_RS03055	COG0826	peptidase U32
BIS30_RS03060	COG0826	peptidase U32
BIS30_RS03065	COG4122	O-methyltransferase activity
BIS30_RS03070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIS30_RS03075	COG3906	Belongs to the UPF0473 family
BIS30_RS03080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIS30_RS03085	COG4472	Bacterial protein of unknown function (DUF965)
BIS30_RS03090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIS30_RS03095	COG0628	permease
BIS30_RS03110	COG3881	PFAM PRC-barrel domain
BIS30_RS03115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIS30_RS03120	COG0457	Tetratricopeptide repeat
BIS30_RS03125	COG0482	sulfurtransferase activity
BIS30_RS03130	COG1104	cysteine desulfurase activity
BIS30_RS03135	COG1959	2 iron, 2 sulfur cluster binding
BIS30_RS03140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIS30_RS03155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BIS30_RS03165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIS30_RS03170	COG0124	histidyl-tRNA synthetase
BIS30_RS03185	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS03185	COG3103	Sh3 type 3 domain protein
BIS30_RS03185	COG4991	sh3 domain protein
BIS30_RS03190	COG1490	D-aminoacyl-tRNA deacylase activity
BIS30_RS03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIS30_RS03200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_RS03205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BIS30_RS03205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIS30_RS03210	COG5416	Lipopolysaccharide assembly protein A domain
BIS30_RS03215	COG0490	domain, Protein
BIS30_RS03220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIS30_RS03220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIS30_RS03230	COG2244	polysaccharide biosynthetic process
BIS30_RS03235	COG2323	membrane
BIS30_RS03245	COG1862	Preprotein translocase
BIS30_RS03250	COG0343	queuine tRNA-ribosyltransferase activity
BIS30_RS03255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIS30_RS03265	COG2255	four-way junction helicase activity
BIS30_RS03270	COG0632	four-way junction helicase activity
BIS30_RS03280	COG2814	Major facilitator Superfamily
BIS30_RS03285	COG0673	inositol 2-dehydrogenase activity
BIS30_RS03290	COG2112	serine threonine protein kinase
BIS30_RS03300	COG1115	amino acid carrier protein
BIS30_RS03305	COG0217	transcriptional regulatory protein
BIS30_RS03315	COG1388	LysM domain
BIS30_RS03335	COG1104	cysteine desulfurase activity
BIS30_RS03340	COG1827	regulation of RNA biosynthetic process
BIS30_RS03345	COG0077	Prephenate dehydratase
BIS30_RS03350	COG4492	Belongs to the UPF0735 family
BIS30_RS03355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIS30_RS03360	COG3290	protein histidine kinase activity
BIS30_RS03370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIS30_RS03375	COG2868	ribosomal protein
BIS30_RS03380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BIS30_RS03385	COG1994	Peptidase M50
BIS30_RS03390	COG0739	heme binding
BIS30_RS03395	COG2894	cell division
BIS30_RS03400	COG0850	regulation of cytokinetic process
BIS30_RS03405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BIS30_RS03415	COG1077	Cell shape determining protein MreB Mrl
BIS30_RS03420	COG2003	Belongs to the UPF0758 family
BIS30_RS03425	COG0424	maF-like protein
BIS30_RS03435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIS30_RS03440	COG0285	dihydrofolate synthase activity
BIS30_RS03445	COG0525	valine-tRNA ligase activity
BIS30_RS03455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_RS03460	COG1388	LysM domain
BIS30_RS03465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIS30_RS03470	COG0113	porphobilinogen synthase activity
BIS30_RS03475	COG1587	Uroporphyrinogen-III synthase
BIS30_RS03480	COG0181	hydroxymethylbilane synthase activity
BIS30_RS03485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIS30_RS03490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BIS30_RS03500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIS30_RS03505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BIS30_RS03510	COG1067	ATP-dependent peptidase activity
BIS30_RS03510	COG0470	DNA polymerase III
BIS30_RS03520	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIS30_RS03525	COG0457	Tetratricopeptide repeat
BIS30_RS03525	COG1477	protein flavinylation
BIS30_RS03530	COG0066	3-isopropylmalate dehydratase activity
BIS30_RS03535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIS30_RS03540	COG0473	3-isopropylmalate dehydrogenase activity
BIS30_RS03550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIS30_RS03555	COG0440	acetolactate synthase activity
BIS30_RS03560	COG0028	Belongs to the TPP enzyme family
BIS30_RS03570	COG0454	-acetyltransferase
BIS30_RS03580	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BIS30_RS03590	COG0622	Phosphoesterase
BIS30_RS03595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIS30_RS03600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BIS30_RS03605	COG5401	PFAM Sporulation and spore germination
BIS30_RS03610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BIS30_RS03615	COG1846	Transcriptional regulator
BIS30_RS03620	COG2197	response regulator
BIS30_RS03625	COG0824	Thioesterase
BIS30_RS03630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIS30_RS03635	COG1053	succinate dehydrogenase
BIS30_RS03640	COG2009	succinate dehydrogenase
BIS30_RS03650	COG1719	4-vinyl reductase, 4VR
BIS30_RS03655	COG0527	aspartate kinase activity
BIS30_RS03660	COG0322	excinuclease ABC activity
BIS30_RS03665	COG3118	belongs to the thioredoxin family
BIS30_RS03670	COG3534	alpha-L-arabinofuranosidase
BIS30_RS03675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BIS30_RS03680	COG2086	electron transfer activity
BIS30_RS03685	COG1024	Enoyl-CoA hydratase
BIS30_RS03690	COG1309	transcriptional regulator
BIS30_RS03695	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS03700	COG3766	membrane
BIS30_RS03705	COG1193	negative regulation of DNA recombination
BIS30_RS03715	COG1286	toxin biosynthetic process
BIS30_RS03720	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIS30_RS03725	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIS30_RS03730	COG0072	phenylalanine-tRNA ligase activity
BIS30_RS03730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_RS03735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIS30_RS03740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIS30_RS03750	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_RS03755	COG0277	FAD linked oxidase domain protein
BIS30_RS03760	COG0247	lactate metabolic process
BIS30_RS03765	COG0346	lactoylglutathione lyase activity
BIS30_RS03770	COG1966	Carbon starvation protein
BIS30_RS03785	COG1695	Transcriptional regulator
BIS30_RS03790	COG3534	alpha-L-arabinofuranosidase
BIS30_RS03795	COG0395	ABC-type sugar transport system, permease component
BIS30_RS03805	COG1653	transport
BIS30_RS03810	COG0371	Dehydrogenase
BIS30_RS03815	COG0647	UMP catabolic process
BIS30_RS03820	COG0235	Class ii aldolase
BIS30_RS03825	COG1069	ribulokinase activity
BIS30_RS03830	COG2160	L-arabinose isomerase activity
BIS30_RS03835	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_RS03840	COG1363	Peptidase, m42
BIS30_RS03850	COG3326	Membrane
BIS30_RS03855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIS30_RS03860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BIS30_RS03865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIS30_RS03880	COG1346	cytolysis
BIS30_RS03885	COG1380	Effector of murein hydrolase LrgA
BIS30_RS03900	COG1011	Hydrolase
BIS30_RS03905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIS30_RS03915	COG0398	Pfam SNARE associated Golgi protein
BIS30_RS03920	COG1484	DNA-dependent DNA replication
BIS30_RS03925	COG3611	Membrane attachment protein
BIS30_RS03930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIS30_RS03935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BIS30_RS03940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIS30_RS03945	COG1733	regulation of RNA biosynthetic process
BIS30_RS03950	COG2814	Major facilitator Superfamily
BIS30_RS03955	COG0656	L-ascorbic acid biosynthetic process
BIS30_RS03960	COG0237	dephospho-CoA kinase activity
BIS30_RS03975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIS30_RS03980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_RS03980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_RS03985	COG5002	protein histidine kinase activity
BIS30_RS03990	COG0745	RESPONSE REGULATOR receiver
BIS30_RS03995	COG0039	L-malate dehydrogenase activity
BIS30_RS04000	COG0538	isocitrate dehydrogenase activity
BIS30_RS04005	COG0372	Belongs to the citrate synthase family
BIS30_RS04010	COG2707	UPF0756 membrane protein
BIS30_RS04015	COG0628	permease
BIS30_RS04020	COG3030	protein affecting phage T7 exclusion by the F plasmid
BIS30_RS04025	COG0469	pyruvate kinase activity
BIS30_RS04030	COG0205	6-phosphofructokinase activity
BIS30_RS04035	COG0825	malonyl-CoA metabolic process
BIS30_RS04040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIS30_RS04045	COG0281	malic enzyme
BIS30_RS04050	COG0587	DNA-directed DNA polymerase activity
BIS30_RS04070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIS30_RS04080	COG4109	DRTGG domain
BIS30_RS04085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIS30_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS04100	COG0165	Argininosuccinate lyase
BIS30_RS04105	COG0137	argininosuccinate synthase activity
BIS30_RS04110	COG0521	Mo-molybdopterin cofactor biosynthetic process
BIS30_RS04115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIS30_RS04120	COG0827	DNA restriction-modification system
BIS30_RS04125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIS30_RS04130	COG3874	Sporulation protein YtfJ
BIS30_RS04140	COG1714	RDD family
BIS30_RS04145	COG0616	signal peptide processing
BIS30_RS04150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIS30_RS04155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BIS30_RS04160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIS30_RS04170	COG0301	tRNA thio-modification
BIS30_RS04175	COG1104	cysteine desulfurase activity
BIS30_RS04180	COG1114	Component of the transport system for branched-chain amino acids
BIS30_RS04185	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIS30_RS04190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BIS30_RS04195	COG1309	transcriptional regulator
BIS30_RS04200	COG1956	GAF domain-containing protein
BIS30_RS04205	COG2203	Gaf domain
BIS30_RS04205	COG2199	diguanylate cyclase activity
BIS30_RS04210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIS30_RS04220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIS30_RS04225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIS30_RS04230	COG0454	-acetyltransferase
BIS30_RS04235	COG0517	IMP dehydrogenase activity
BIS30_RS04240	COG0123	including yeast histone deacetylase and acetoin utilization protein
BIS30_RS04245	COG1360	Flagellar Motor Protein
BIS30_RS04250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIS30_RS04255	COG1609	Transcriptional regulator
BIS30_RS04260	COG1605	Chorismate mutase
BIS30_RS04260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BIS30_RS04265	COG3118	belongs to the thioredoxin family
BIS30_RS04270	COG4980	gas vesicle protein
BIS30_RS04275	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIS30_RS04280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIS30_RS04285	COG1674	ftsk spoiiie
BIS30_RS04290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_RS04295	COG4848	Belongs to the UPF0354 family
BIS30_RS04300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS04310	COG1363	Peptidase, m42
BIS30_RS04315	COG5584	Small secreted protein
BIS30_RS04320	COG0281	malic enzyme
BIS30_RS04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS04330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIS30_RS04340	COG0510	thiamine kinase activity
BIS30_RS04345	COG1523	belongs to the glycosyl hydrolase 13 family
BIS30_RS04350	COG1597	lipid kinase activity
BIS30_RS04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BIS30_RS04365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_RS04370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_RS04375	COG2252	PERMEase
BIS30_RS04380	COG4473	ABC transporter
BIS30_RS04385	COG1131	(ABC) transporter
BIS30_RS04390	COG1349	DNA-binding transcription factor activity
BIS30_RS04395	COG1187	pseudouridine synthase activity
BIS30_RS04400	COG2244	polysaccharide biosynthetic process
BIS30_RS04405	COG2081	HI0933 family
BIS30_RS04410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BIS30_RS04420	COG5578	integral membrane protein
BIS30_RS04425	COG0673	inositol 2-dehydrogenase activity
BIS30_RS04430	COG1653	transport
BIS30_RS04435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BIS30_RS04440	COG4209	transmembrane transport
BIS30_RS04445	COG2207	Transcriptional regulator
BIS30_RS04450	COG1653	transport
BIS30_RS04455	COG0395	ABC-type sugar transport system, permease component
BIS30_RS04460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_RS04465	COG2124	cytochrome p450
BIS30_RS04470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BIS30_RS04480	COG0156	8-amino-7-oxononanoate synthase activity
BIS30_RS04485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIS30_RS04500	COG1073	alpha beta
BIS30_RS04505	COG1609	Transcriptional regulator
BIS30_RS04510	COG1653	transport
BIS30_RS04515	COG1175	transmembrane transport
BIS30_RS04520	COG0395	ABC-type sugar transport system, permease component
BIS30_RS04525	COG1486	melibiose metabolic process
BIS30_RS04530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIS30_RS04535	COG0495	leucyl-tRNA aminoacylation
BIS30_RS04545	COG2202	Pas domain
BIS30_RS04545	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS04550	COG2814	Major facilitator Superfamily
BIS30_RS04555	COG2433	Pfam Transposase IS66
BIS30_RS04560	COG0577	efflux transmembrane transporter activity
BIS30_RS04565	COG1136	(ABC) transporter
BIS30_RS04570	COG2205	protein histidine kinase activity
BIS30_RS04575	COG0745	RESPONSE REGULATOR receiver
BIS30_RS04585	COG1136	(ABC) transporter
BIS30_RS04600	COG1131	(ABC) transporter
BIS30_RS04605	COG1725	Transcriptional regulator
BIS30_RS04620	COG1242	4 iron, 4 sulfur cluster binding
BIS30_RS04625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BIS30_RS04635	COG2267	carboxylic ester hydrolase activity
BIS30_RS04640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIS30_RS04645	COG1113	amino acid transport
BIS30_RS04655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIS30_RS04660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BIS30_RS04670	COG1506	peptidase
BIS30_RS04675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIS30_RS04680	COG1116	anion transmembrane transporter activity
BIS30_RS04685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIS30_RS04700	COG0494	nUDIX hydrolase
BIS30_RS04705	COG4824	toxin secretion phage lysis holin
BIS30_RS04710	COG0783	Belongs to the Dps family
BIS30_RS04725	COG1854	S-ribosylhomocysteine lyase activity
BIS30_RS04730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BIS30_RS04735	COG0288	reversible hydration of carbon dioxide
BIS30_RS04740	COG0254	rRNA binding
BIS30_RS04745	COG1271	oxidase subunit
BIS30_RS04750	COG1294	oxidase, subunit
BIS30_RS04760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_RS04765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_RS04765	COG1321	iron dependent repressor
BIS30_RS04770	COG1121	(ABC) transporter
BIS30_RS04775	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIS30_RS04780	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_RS04785	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS04790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BIS30_RS04795	COG0596	Alpha beta hydrolase
BIS30_RS04800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BIS30_RS04805	COG1169	isochorismate synthase
BIS30_RS04810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIS30_RS04815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_RS04820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_RS04825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_RS04830	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS04840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_RS04845	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS04850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_RS04855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BIS30_RS04860	COG0058	SHG alpha-glucan phosphorylase activity
BIS30_RS04865	COG0297	glycogen (starch) synthase activity
BIS30_RS04870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIS30_RS04875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIS30_RS04880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIS30_RS05010	COG3859	Proton-coupled thiamine transporter YuaJ
BIS30_RS05015	COG1247	-acetyltransferase
BIS30_RS05020	COG2268	Band 7 protein
BIS30_RS05025	COG1585	Membrane protein implicated in regulation of membrane protease activity
BIS30_RS05030	COG2318	DinB family
BIS30_RS05040	COG1454	alcohol dehydrogenase
BIS30_RS05045	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS05050	COG1510	regulation of RNA biosynthetic process
BIS30_RS05060	COG0569	domain protein
BIS30_RS05065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIS30_RS05070	COG4682	membrane
BIS30_RS05075	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIS30_RS05080	COG0477	Major facilitator Superfamily
BIS30_RS05085	COG5553	Cysteine dioxygenase type I
BIS30_RS05095	COG1968	undecaprenyl-diphosphatase activity
BIS30_RS05100	COG0628	permease
BIS30_RS05105	COG0673	inositol 2-dehydrogenase activity
BIS30_RS05110	COG4806	L-rhamnose isomerase
BIS30_RS05115	COG3254	rhamnose metabolic process
BIS30_RS05120	COG1070	Carbohydrate kinase
BIS30_RS05125	COG1349	DNA-binding transcription factor activity
BIS30_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS05130	COG3347	Dehydrogenase
BIS30_RS05135	COG0840	transmembrane signaling receptor activity
BIS30_RS05140	COG0840	transmembrane signaling receptor activity
BIS30_RS05145	COG0840	transmembrane signaling receptor activity
BIS30_RS05150	COG0840	transmembrane signaling receptor activity
BIS30_RS05165	COG2070	2-Nitropropane dioxygenase
BIS30_RS05170	COG0432	Pfam Uncharacterised protein family UPF0047
BIS30_RS05175	COG0366	Alpha amylase catalytic
BIS30_RS05190	COG1253	flavin adenine dinucleotide binding
BIS30_RS05195	COG2738	Putative neutral zinc metallopeptidase
BIS30_RS05210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIS30_RS05225	COG0166	Belongs to the GPI family
BIS30_RS05230	COG1979	alcohol dehydrogenase
BIS30_RS05235	COG1979	alcohol dehydrogenase
BIS30_RS05240	COG2155	Conserved Protein
BIS30_RS05245	COG1098	S1 RNA binding domain
BIS30_RS05250	COG0436	Aminotransferase
BIS30_RS05255	COG1522	sequence-specific DNA binding
BIS30_RS05260	COG2267	carboxylic ester hydrolase activity
BIS30_RS05270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIS30_RS05275	COG2205	protein histidine kinase activity
BIS30_RS05285	COG5018	Exonuclease
BIS30_RS05295	COG2814	Major facilitator Superfamily
BIS30_RS05300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_RS05305	COG3011	Protein conserved in bacteria
BIS30_RS05315	COG3290	protein histidine kinase activity
BIS30_RS05320	COG4565	transcriptional regulatory protein
BIS30_RS05325	COG3493	citrate carrier protein
BIS30_RS05335	COG2111	Na H antiporter
BIS30_RS05335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BIS30_RS05340	COG2111	Na H antiporter
BIS30_RS05345	COG1006	Multisubunit Na H antiporter MnhC subunit
BIS30_RS05350	COG0651	ATP synthesis coupled electron transport
BIS30_RS05360	COG2212	antiporter activity
BIS30_RS05365	COG1320	monovalent cation:proton antiporter activity
BIS30_RS05370	COG2050	protein possibly involved in aromatic compounds catabolism
BIS30_RS05375	COG2197	response regulator
BIS30_RS05380	COG4585	Histidine kinase
BIS30_RS05390	COG0142	geranyltranstransferase activity
BIS30_RS05405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BIS30_RS05410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIS30_RS05415	COG1335	isochorismatase
BIS30_RS05420	COG5506	Protein of unknown function (DUF1694)
BIS30_RS05435	COG0628	permease
BIS30_RS05450	COG1418	mRNA catabolic process
BIS30_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS05465	COG1511	domain protein
BIS30_RS05470	COG1674	ftsk spoiiie
BIS30_RS05470	COG0433	COG0433 Predicted ATPase
BIS30_RS05475	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIS30_RS05480	COG5417	Belongs to the EsaB family
BIS30_RS05485	COG4842	Belongs to the WXG100 family
BIS30_RS05490	COG2508	Transcriptional regulator
BIS30_RS05490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIS30_RS05495	COG0686	Belongs to the AlaDH PNT family
BIS30_RS05500	COG5634	Uncharacterized conserved protein (DUF2278)
BIS30_RS05505	COG3251	PFAM MbtH domain protein
BIS30_RS05510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS05515	COG3433	isochorismatase activity
BIS30_RS05515	COG1535	isochorismatase
BIS30_RS05520	COG1021	2,3-dihydroxybenzoate-AMP ligase
BIS30_RS05525	COG1169	isochorismate synthase
BIS30_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS05535	COG2819	hydrolase of the alpha beta superfamily
BIS30_RS05540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIS30_RS05545	COG1268	BioY protein
BIS30_RS05550	COG2056	Na+-H+ antiporter family
BIS30_RS05555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIS30_RS05560	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BIS30_RS05565	COG3584	3D domain protein
BIS30_RS05580	COG1252	NADH dehydrogenase
BIS30_RS05585	COG0492	ferredoxin-NADP+ reductase activity
BIS30_RS05595	COG0516	GMP reductase activity
BIS30_RS05610	COG1131	(ABC) transporter
BIS30_RS05630	COG0456	acetyltransferase
BIS30_RS05640	COG0316	Belongs to the HesB IscA family
BIS30_RS05645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIS30_RS05650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_RS05655	COG4844	belongs to the
BIS30_RS05660	COG1252	NADH dehydrogenase
BIS30_RS05665	COG4837	Protein of unknown function (DUF1462)
BIS30_RS05670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BIS30_RS05675	COG0823	Involved in the tonB-independent uptake of proteins
BIS30_RS05675	COG1506	peptidase
BIS30_RS05675	COG4946	Tricorn protease homolog
BIS30_RS05680	COG0083	homoserine kinase activity
BIS30_RS05685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIS30_RS05690	COG0460	homoserine dehydrogenase
BIS30_RS05695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_RS05700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIS30_RS05705	COG0647	UMP catabolic process
BIS30_RS05710	COG2445	Protein of unknown function DUF86
BIS30_RS05715	COG4470	Protein conserved in bacteria
BIS30_RS05725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BIS30_RS05730	COG0739	heme binding
BIS30_RS05740	COG3377	Domain of unknown function (DUF1805)
BIS30_RS05745	COG0737	Belongs to the 5'-nucleotidase family
BIS30_RS05750	COG0730	response to heat
BIS30_RS05755	COG1801	Protein of unknown function DUF72
BIS30_RS05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIS30_RS05770	COG2508	Transcriptional regulator
BIS30_RS05775	COG2233	PERMEase
BIS30_RS05780	COG2233	PERMEase
BIS30_RS05785	COG3648	Uricase
BIS30_RS05785	COG3195	allantoin biosynthetic process
BIS30_RS05790	COG2351	hydroxyisourate hydrolase activity
BIS30_RS05805	COG2080	2 iron, 2 sulfur cluster binding
BIS30_RS05810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BIS30_RS05815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BIS30_RS05820	COG2068	MobA-Related Protein
BIS30_RS05825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BIS30_RS05830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BIS30_RS05835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_RS05850	COG2356	endonuclease I
BIS30_RS05855	COG3842	ATPase activity
BIS30_RS05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_RS05870	COG0395	ABC-type sugar transport system, permease component
BIS30_RS05875	COG1175	transmembrane transport
BIS30_RS05880	COG1653	transport
BIS30_RS05885	COG2222	sugar isomerase
BIS30_RS05890	COG0322	excinuclease ABC activity
BIS30_RS05895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_RS05910	COG0346	lactoylglutathione lyase activity
BIS30_RS05915	COG0640	Transcriptional regulator
BIS30_RS05920	COG0719	Fe-S assembly protein
BIS30_RS05925	COG0822	iron-sulfur transferase activity
BIS30_RS05930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIS30_RS05935	COG0719	Fe-S assembly protein
BIS30_RS05940	COG0396	ATPase activity
BIS30_RS05955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIS30_RS05960	COG1464	Belongs to the NlpA lipoprotein family
BIS30_RS05965	COG2011	ABC-type metal ion transport system permease component
BIS30_RS05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIS30_RS05980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS05985	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIS30_RS05995	COG0509	glycine decarboxylation via glycine cleavage system
BIS30_RS06000	COG1393	Belongs to the ArsC family
BIS30_RS06005	COG1960	acyl-CoA dehydrogenase activity
BIS30_RS06010	COG0183	Belongs to the thiolase family
BIS30_RS06025	COG0506	proline dehydrogenase activity
BIS30_RS06035	COG5577	PFAM Coat F domain
BIS30_RS06040	COG1846	Transcriptional regulator
BIS30_RS06045	COG0477	Major facilitator Superfamily
BIS30_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS06060	COG0583	DNA-binding transcription factor activity
BIS30_RS06070	COG1120	ATPase activity
BIS30_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS06090	COG0783	Belongs to the Dps family
BIS30_RS06095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_RS06100	COG0745	RESPONSE REGULATOR receiver
BIS30_RS06105	COG2770	Histidine kinase
BIS30_RS06105	COG2205	protein histidine kinase activity
BIS30_RS06115	COG1309	transcriptional regulator
BIS30_RS06120	COG0114	fumarate hydratase activity
BIS30_RS06130	COG0697	spore germination
BIS30_RS06145	COG2197	response regulator
BIS30_RS06150	COG4585	Histidine kinase
BIS30_RS06155	COG4758	membrane
BIS30_RS06160	COG3595	metallopeptidase activity
BIS30_RS06165	COG1842	Phage shock protein A
BIS30_RS06170	COG4758	membrane
BIS30_RS06175	COG2814	Major facilitator Superfamily
BIS30_RS06180	COG2096	Adenosyltransferase
BIS30_RS06185	COG1120	ATPase activity
BIS30_RS06190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS06195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS06205	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS06210	COG3386	PFAM SMP-30 Gluconolaconase
BIS30_RS06215	COG2205	protein histidine kinase activity
BIS30_RS06220	COG0745	RESPONSE REGULATOR receiver
BIS30_RS06230	COG1191	sigma factor activity
BIS30_RS06240	COG2140	Oxalate decarboxylase
BIS30_RS06250	COG0577	efflux transmembrane transporter activity
BIS30_RS06260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIS30_RS06265	COG1120	ATPase activity
BIS30_RS06270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS06275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS06280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS06290	COG0531	amino acid
BIS30_RS06300	COG1988	membrane-bound metal-dependent
BIS30_RS06305	COG1368	sulfuric ester hydrolase activity
BIS30_RS06310	COG1910	domain protein
BIS30_RS06315	COG0725	ABC transporter, periplasmic molybdate-binding protein
BIS30_RS06320	COG4149	molybdate abc transporter
BIS30_RS06325	COG0656	L-ascorbic acid biosynthetic process
BIS30_RS06335	COG0025	NhaP-type Na H and K H
BIS30_RS06340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_RS06345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_RS06350	COG3973	AAA domain
BIS30_RS06355	COG2860	membrane
BIS30_RS06360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BIS30_RS06365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BIS30_RS06370	COG2217	Heavy metal translocating P-type atpase
BIS30_RS06375	COG2217	Heavy metal translocating P-type atpase
BIS30_RS06380	COG2608	mercury ion transmembrane transporter activity
BIS30_RS06385	COG1937	Protein conserved in bacteria
BIS30_RS06390	COG0673	inositol 2-dehydrogenase activity
BIS30_RS06395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIS30_RS06400	COG1289	transmembrane transporter activity
BIS30_RS06405	COG1802	Transcriptional regulator
BIS30_RS06410	COG0697	spore germination
BIS30_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS06440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BIS30_RS06445	COG0557	exoribonuclease II activity
BIS30_RS06450	COG1647	Serine aminopeptidase, S33
BIS30_RS06455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIS30_RS06460	COG0596	Alpha beta hydrolase
BIS30_RS06465	COG1476	TRANSCRIPTIONal
BIS30_RS06470	COG1396	sequence-specific DNA binding
BIS30_RS06475	COG1396	sequence-specific DNA binding
BIS30_RS06480	COG1733	regulation of RNA biosynthetic process
BIS30_RS06505	COG1131	(ABC) transporter
BIS30_RS06535	COG1174	glycine betaine transport
BIS30_RS06540	COG1732	Glycine betaine
BIS30_RS06545	COG1174	glycine betaine transport
BIS30_RS06550	COG0517	IMP dehydrogenase activity
BIS30_RS06550	COG1125	glycine betaine transport
BIS30_RS06555	COG1510	regulation of RNA biosynthetic process
BIS30_RS06570	COG1174	glycine betaine transport
BIS30_RS06575	COG1732	Glycine betaine
BIS30_RS06580	COG1174	glycine betaine transport
BIS30_RS06585	COG1125	glycine betaine transport
BIS30_RS06585	COG0517	IMP dehydrogenase activity
BIS30_RS06590	COG1510	regulation of RNA biosynthetic process
BIS30_RS06600	COG3064	Membrane
BIS30_RS06605	COG4640	response to antibiotic
BIS30_RS06610	COG0456	acetyltransferase
BIS30_RS06620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIS30_RS06625	COG0149	triose-phosphate isomerase activity
BIS30_RS06630	COG0126	phosphoglycerate kinase activity
BIS30_RS06640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIS30_RS06645	COG2390	Transcriptional regulator
BIS30_RS06650	COG2814	Major facilitator Superfamily
BIS30_RS06655	COG1609	Transcriptional regulator
BIS30_RS06660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_RS06665	COG0697	spore germination
BIS30_RS06670	COG1113	amino acid transport
BIS30_RS06675	COG3858	chitin binding
BIS30_RS06680	COG1556	Lactate utilization protein
BIS30_RS06685	COG1139	Iron-sulfur cluster binding protein
BIS30_RS06705	COG2197	response regulator
BIS30_RS06710	COG4585	Histidine kinase
BIS30_RS06715	COG0842	Transport permease protein
BIS30_RS06720	COG1131	(ABC) transporter
BIS30_RS06725	COG0596	Alpha beta hydrolase
BIS30_RS06730	COG2208	phosphoserine phosphatase activity
BIS30_RS06740	COG1874	Beta-galactosidase
BIS30_RS06745	COG3833	ABC-type maltose transport systems, permease component
BIS30_RS06750	COG1175	transmembrane transport
BIS30_RS06755	COG2182	Extracellular solute-binding protein
BIS30_RS06760	COG1609	Transcriptional regulator
BIS30_RS06765	COG2186	Transcriptional regulator
BIS30_RS06770	COG1620	l-lactate permease
BIS30_RS06775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIS30_RS06785	COG5039	Polysaccharide pyruvyl transferase
BIS30_RS06790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_RS06795	COG0110	maltose O-acetyltransferase activity
BIS30_RS06800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIS30_RS06805	COG2244	polysaccharide biosynthetic process
BIS30_RS06810	COG1216	Glycosyl transferase, family 2
BIS30_RS06815	COG5039	Polysaccharide pyruvyl transferase
BIS30_RS06820	COG1216	Glycosyl transferase, family 2
BIS30_RS06830	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS06835	COG1215	transferase activity, transferring glycosyl groups
BIS30_RS06840	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS06845	COG1086	Polysaccharide biosynthesis protein
BIS30_RS06850	COG0489	protein tyrosine kinase activity
BIS30_RS06855	COG3944	biosynthesis protein
BIS30_RS06860	COG1396	sequence-specific DNA binding
BIS30_RS06865	COG2272	Belongs to the type-B carboxylesterase lipase family
BIS30_RS06875	COG3479	Phenolic acid decarboxylase
BIS30_RS06885	COG1794	racemase activity, acting on amino acids and derivatives
BIS30_RS06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_RS06895	COG1621	beta-fructofuranosidase activity
BIS30_RS06900	COG1621	beta-fructofuranosidase activity
BIS30_RS06905	COG0531	amino acid
BIS30_RS06910	COG1309	transcriptional regulator
BIS30_RS06915	COG2076	Multidrug Resistance protein
BIS30_RS06920	COG2076	Multidrug Resistance protein
BIS30_RS06940	COG1611	Belongs to the LOG family
BIS30_RS06945	COG1694	Mazg nucleotide pyrophosphohydrolase
BIS30_RS06950	COG0659	secondary active sulfate transmembrane transporter activity
BIS30_RS06955	COG0288	reversible hydration of carbon dioxide
BIS30_RS06960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIS30_RS06965	COG0577	efflux transmembrane transporter activity
BIS30_RS06970	COG1136	(ABC) transporter
BIS30_RS06975	COG5002	protein histidine kinase activity
BIS30_RS06980	COG0745	RESPONSE REGULATOR receiver
BIS30_RS06990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BIS30_RS06995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS07000	COG1481	regulation of sporulation
BIS30_RS07005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BIS30_RS07010	COG1660	Displays ATPase and GTPase activities
BIS30_RS07015	COG1051	belongs to the nudix hydrolase family
BIS30_RS07020	COG0492	ferredoxin-NADP+ reductase activity
BIS30_RS07025	COG0791	NLP P60 protein
BIS30_RS07025	COG3883	PFAM NLP P60 protein
BIS30_RS07030	COG0457	Tetratricopeptide repeat
BIS30_RS07035	COG1132	(ABC) transporter
BIS30_RS07055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIS30_RS07055	COG0140	phosphoribosyl-ATP diphosphatase activity
BIS30_RS07060	COG0107	imidazoleglycerol-phosphate synthase activity
BIS30_RS07065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIS30_RS07070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIS30_RS07075	COG0131	Imidazoleglycerol-phosphate dehydratase
BIS30_RS07080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIS30_RS07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BIS30_RS07090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIS30_RS07095	COG4990	cell redox homeostasis
BIS30_RS07100	COG5297	Belongs to the glycosyl hydrolase family 6
BIS30_RS07105	COG0110	maltose O-acetyltransferase activity
BIS30_RS07110	COG0546	phosphoglycolate phosphatase activity
BIS30_RS07115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BIS30_RS07120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIS30_RS07125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIS30_RS07130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIS30_RS07135	COG0363	glucosamine-6-phosphate deaminase activity
BIS30_RS07140	COG2188	Transcriptional regulator
BIS30_RS07145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BIS30_RS07150	COG1846	Transcriptional regulator
BIS30_RS07155	COG2124	cytochrome p450
BIS30_RS07165	COG1846	Transcriptional regulator
BIS30_RS07170	COG2814	Major facilitator Superfamily
BIS30_RS07175	COG1950	PFAM Membrane protein of
BIS30_RS07180	COG1983	PspC domain protein
BIS30_RS07185	COG3595	metallopeptidase activity
BIS30_RS07200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIS30_RS07210	COG4897	Protein conserved in bacteria
BIS30_RS07215	COG0574	Belongs to the PEP-utilizing enzyme family
BIS30_RS07215	COG3848	Pyruvate phosphate dikinase
BIS30_RS07220	COG1309	transcriptional regulator
BIS30_RS07225	COG2814	Major facilitator Superfamily
BIS30_RS07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_RS07240	COG0793	Belongs to the peptidase S41A family
BIS30_RS07240	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS07245	COG2177	Part of the ABC transporter FtsEX involved in
BIS30_RS07250	COG2884	Cell division ATP-binding protein ftsE
BIS30_RS07255	COG2010	Cytochrome c
BIS30_RS07260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS07270	COG0653	protein targeting
BIS30_RS07275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIS30_RS07290	COG1516	flagellar protein fliS
BIS30_RS07300	COG1334	flagellar protein FlaG
BIS30_RS07305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIS30_RS07310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIS30_RS07315	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BIS30_RS07325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIS30_RS07330	COG1256	bacterial-type flagellum assembly
BIS30_RS07330	COG4786	Flagellar basal body rod
BIS30_RS07335	COG3418	PFAM FlgN family protein
BIS30_RS07340	COG2747	anti-sigma28 factor FlgM
BIS30_RS07350	COG1040	competence protein
BIS30_RS07360	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BIS30_RS07365	COG1307	EDD domain protein, DegV family
BIS30_RS07370	COG2197	response regulator
BIS30_RS07375	COG4585	Histidine kinase
BIS30_RS07380	COG1739	Uncharacterized protein family UPF0029
BIS30_RS07385	COG1316	TRANSCRIPTIONal
BIS30_RS07390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIS30_RS07395	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS07400	COG1215	transferase activity, transferring glycosyl groups
BIS30_RS07405	COG3206	protein involved in exopolysaccharide biosynthesis
BIS30_RS07410	COG3307	-O-antigen
BIS30_RS07415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_RS07420	COG0438	transferase activity, transferring glycosyl groups
BIS30_RS07420	COG0297	glycogen (starch) synthase activity
BIS30_RS07425	COG2244	polysaccharide biosynthetic process
BIS30_RS07440	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS07440	COG2247	cell wall binding repeat
BIS30_RS07445	COG2247	cell wall binding repeat
BIS30_RS07445	COG2385	sporulation resulting in formation of a cellular spore
BIS30_RS07455	COG1316	TRANSCRIPTIONal
BIS30_RS07460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BIS30_RS07480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_RS07485	COG1134	teichoic acid transport
BIS30_RS07490	COG1682	transport, permease protein
BIS30_RS07505	COG1215	transferase activity, transferring glycosyl groups
BIS30_RS07505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIS30_RS07555	COG4193	domain, Protein
BIS30_RS07560	COG1482	cell wall glycoprotein biosynthetic process
BIS30_RS07575	COG0814	amino acid
BIS30_RS07585	COG2814	Major facilitator Superfamily
BIS30_RS07590	COG1316	TRANSCRIPTIONal
BIS30_RS07595	COG0561	phosphatase activity
BIS30_RS07600	COG0791	NLP P60 protein
BIS30_RS07610	COG2843	Capsule synthesis protein
BIS30_RS07620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIS30_RS07625	COG1609	Transcriptional regulator
BIS30_RS07630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_RS07635	COG1869	D-ribose catabolic process
BIS30_RS07640	COG1129	ABC transporter
BIS30_RS07645	COG1172	Belongs to the binding-protein-dependent transport system permease family
BIS30_RS07650	COG1879	ABC-type sugar transport system periplasmic component
BIS30_RS07655	COG3103	Sh3 type 3 domain protein
BIS30_RS07665	COG2249	NAD(P)H dehydrogenase (quinone) activity
BIS30_RS07670	COG3527	Alpha-acetolactate decarboxylase
BIS30_RS07675	COG0028	Belongs to the TPP enzyme family
BIS30_RS07680	COG0583	DNA-binding transcription factor activity
BIS30_RS07685	COG5337	Spore coat protein CotH
BIS30_RS07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIS30_RS07705	COG0405	Gamma-glutamyltransferase
BIS30_RS07710	COG1522	sequence-specific DNA binding
BIS30_RS07715	COG2059	Chromate
BIS30_RS07720	COG2059	Chromate
BIS30_RS07730	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIS30_RS07735	COG0583	DNA-binding transcription factor activity
BIS30_RS07745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS07745	COG2207	Transcriptional regulator
BIS30_RS07775	COG5444	nuclease activity
BIS30_RS07790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_RS07795	COG4464	protein tyrosine phosphatase activity
BIS30_RS07800	COG0489	protein tyrosine kinase activity
BIS30_RS07805	COG3944	biosynthesis protein
BIS30_RS07815	COG4715	Zinc finger, swim domain protein
BIS30_RS07820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIS30_RS07825	COG0561	phosphatase activity
BIS30_RS07830	COG1349	DNA-binding transcription factor activity
BIS30_RS07835	COG0629	single-stranded DNA binding
BIS30_RS07850	COG3764	Sortase (surface protein transpeptidase)
BIS30_RS07860	COG3279	Response regulator of the LytR AlgR family
BIS30_RS07865	COG2972	Histidine kinase
BIS30_RS07865	COG0745	RESPONSE REGULATOR receiver
BIS30_RS07870	COG1970	mechanosensitive ion channel activity
BIS30_RS07875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIS30_RS07880	COG0457	Tetratricopeptide repeat
BIS30_RS07885	COG4786	Flagellar basal body rod
BIS30_RS07890	COG4786	Flagellar basal body rod
BIS30_RS07895	COG1077	Cell shape determining protein MreB Mrl
BIS30_RS07900	COG1609	Transcriptional regulator
BIS30_RS07905	COG1846	Transcriptional regulator
BIS30_RS07910	COG2814	Major facilitator Superfamily
BIS30_RS07915	COG3420	alginic acid biosynthetic process
BIS30_RS07920	COG1953	Uracil, thiamine, allantoin
BIS30_RS07925	COG0477	Major facilitator Superfamily
BIS30_RS07930	COG1335	isochorismatase
BIS30_RS07940	COG0004	ammonium transporteR
BIS30_RS07945	COG0347	Belongs to the P(II) protein family
BIS30_RS07950	COG0671	phosphoesterase, PA-phosphatase related
BIS30_RS07960	COG0739	heme binding
BIS30_RS07965	COG1247	-acetyltransferase
BIS30_RS07985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_RS07990	COG0789	Transcriptional regulator
BIS30_RS08000	COG2910	NAD(P)H-binding
BIS30_RS08005	COG1959	2 iron, 2 sulfur cluster binding
BIS30_RS08010	COG0804	urea catabolic process
BIS30_RS08015	COG0832	Belongs to the urease beta subunit family
BIS30_RS08020	COG0831	urea catabolic process
BIS30_RS08050	COG3237	CsbD-like
BIS30_RS08055	COG1994	Peptidase M50
BIS30_RS08060	COG0457	Tetratricopeptide repeat
BIS30_RS08065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIS30_RS08070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BIS30_RS08080	COG2304	oxidoreductase activity
BIS30_RS08085	COG2304	oxidoreductase activity
BIS30_RS08090	COG2385	sporulation resulting in formation of a cellular spore
BIS30_RS08095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIS30_RS08105	COG4836	Membrane
BIS30_RS08120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIS30_RS08125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIS30_RS08130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIS30_RS08135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIS30_RS08140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIS30_RS08155	COG0356	it plays a direct role in the translocation of protons across the membrane
BIS30_RS08165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIS30_RS08170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIS30_RS08175	COG4475	Protein of unknown function (DUF436)
BIS30_RS08180	COG0698	ribose 5-phosphate isomerase
BIS30_RS08185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_RS08190	COG1971	Probably functions as a manganese efflux pump
BIS30_RS08195	COG0009	L-threonylcarbamoyladenylate synthase
BIS30_RS08200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BIS30_RS08220	COG2890	protein-(glutamine-N5) methyltransferase activity
BIS30_RS08225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIS30_RS08235	COG0789	Transcriptional regulator
BIS30_RS08240	COG0679	Auxin Efflux Carrier
BIS30_RS08245	COG0281	malic enzyme
BIS30_RS08250	COG1435	thymidine kinase activity
BIS30_RS08260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIS30_RS08270	COG1494	fructose-1,6-bisphosphatase
BIS30_RS08275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIS30_RS08280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIS30_RS08285	COG0191	fructose-bisphosphate aldolase activity
BIS30_RS08290	COG2204	response regulator
BIS30_RS08295	COG4821	SIS domain
BIS30_RS08300	COG0504	CTP synthase activity
BIS30_RS08305	COG3343	RNA polymerase activity
BIS30_RS08310	COG1960	acyl-CoA dehydrogenase activity
BIS30_RS08315	COG0247	lactate metabolic process
BIS30_RS08315	COG2181	nitrate reductase activity
BIS30_RS08320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_RS08325	COG4294	response to UV
BIS30_RS08335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIS30_RS08340	COG1132	(ABC) transporter
BIS30_RS08345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_RS08355	COG2181	nitrate reductase activity
BIS30_RS08360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BIS30_RS08365	COG1140	nitrate reductase beta subunit
BIS30_RS08370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIS30_RS08375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIS30_RS08385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIS30_RS08390	COG2223	nitrite transmembrane transporter activity
BIS30_RS08395	COG0018	arginyl-trna synthetase
BIS30_RS08400	COG4506	Protein conserved in bacteria
BIS30_RS08410	COG0535	radical SAM domain protein
BIS30_RS08420	COG1131	(ABC) transporter
BIS30_RS08445	COG3391	amine dehydrogenase activity
BIS30_RS08455	COG0457	Tetratricopeptide repeat
BIS30_RS08465	COG0010	Belongs to the arginase family
BIS30_RS08470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BIS30_RS08475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_RS08485	COG1994	Peptidase M50
BIS30_RS08490	COG1942	4-Oxalocrotonate Tautomerase
BIS30_RS08495	COG1846	Transcriptional regulator
BIS30_RS08500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIS30_RS08510	COG3465	dGTPase activity
BIS30_RS08515	COG1078	dGTPase activity
BIS30_RS08520	COG4844	belongs to the
BIS30_RS08530	COG0697	spore germination
BIS30_RS08535	COG0095	Lipoate-protein ligase
BIS30_RS08540	COG0583	DNA-binding transcription factor activity
BIS30_RS08545	COG0280	phosphate acetyltransferase
BIS30_RS08550	COG3253	May function as heme-dependent peroxidase
BIS30_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS08560	COG0436	Aminotransferase
BIS30_RS08565	COG2814	Major facilitator Superfamily
BIS30_RS08570	COG0151	Belongs to the GarS family
BIS30_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS08580	COG1917	Cupin 2, conserved barrel domain protein
BIS30_RS08585	COG0077	Prephenate dehydratase
BIS30_RS08590	COG2814	Major facilitator Superfamily
BIS30_RS08595	COG0833	amino acid
BIS30_RS08600	COG4187	Peptidase family M20/M25/M40
BIS30_RS08605	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS08610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_RS08620	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BIS30_RS08625	COG1091	dTDP-4-dehydrorhamnose reductase activity
BIS30_RS08630	COG1088	dTDP-glucose 4,6-dehydratase activity
BIS30_RS08635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BIS30_RS08640	COG3980	spore coat polysaccharide biosynthesis protein
BIS30_RS08645	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BIS30_RS08650	COG2089	acid synthase
BIS30_RS08655	COG0456	acetyltransferase
BIS30_RS08660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_RS08665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIS30_RS08670	COG0463	Glycosyl transferase, family 2
BIS30_RS08685	COG2363	Small membrane protein
BIS30_RS08690	COG2233	PERMEase
BIS30_RS08700	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS08705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIS30_RS08710	COG1216	Glycosyl transferase, family 2
BIS30_RS08725	COG1695	Transcriptional regulator
BIS30_RS08730	COG0351	phosphomethylpyrimidine kinase
BIS30_RS08740	COG1621	beta-fructofuranosidase activity
BIS30_RS08745	COG1263	PTS System
BIS30_RS08745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS08750	COG2116	formate transmembrane transporter activity
BIS30_RS08755	COG3711	transcriptional antiterminator
BIS30_RS08770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_RS08775	COG0778	Nitroreductase
BIS30_RS08780	COG0772	Belongs to the SEDS family
BIS30_RS08825	COG2261	transglycosylase associated protein
BIS30_RS08830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BIS30_RS08835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIS30_RS08840	COG2246	polysaccharide biosynthetic process
BIS30_RS08845	COG1309	transcriptional regulator
BIS30_RS08855	COG3162	membrane
BIS30_RS08860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS08865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIS30_RS08870	COG2837	iron assimilation
BIS30_RS08875	COG2822	iron ion transport
BIS30_RS08880	COG0352	thiamine-phosphate diphosphorylase activity
BIS30_RS08885	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIS30_RS08890	COG0583	DNA-binding transcription factor activity
BIS30_RS08895	COG1380	Effector of murein hydrolase LrgA
BIS30_RS08900	COG1346	cytolysis
BIS30_RS08905	COG1131	(ABC) transporter
BIS30_RS08930	COG1346	cytolysis
BIS30_RS08935	COG2814	Major facilitator Superfamily
BIS30_RS08940	COG4895	conserved protein (DUF2196)
BIS30_RS08945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BIS30_RS08950	COG0346	lactoylglutathione lyase activity
BIS30_RS08960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_RS08975	COG3711	transcriptional antiterminator
BIS30_RS08980	COG1442	glycosyl transferase family 8
BIS30_RS08985	COG5522	Integral membrane protein (intg_mem_TP0381)
BIS30_RS08990	COG1846	Transcriptional regulator
BIS30_RS08995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIS30_RS09000	COG2234	aminopeptidase activity
BIS30_RS09005	COG2357	RelA SpoT domain protein
BIS30_RS09015	COG1575	Belongs to the MenA family. Type 1 subfamily
BIS30_RS09030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS09035	COG1696	Membrane protein involved in D-alanine export
BIS30_RS09040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_RS09045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BIS30_RS09050	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIS30_RS09055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_RS09060	COG1486	melibiose metabolic process
BIS30_RS09065	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIS30_RS09070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_RS09075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_RS09080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS09080	COG3711	transcriptional antiterminator
BIS30_RS09085	COG2094	Belongs to the DNA glycosylase MPG family
BIS30_RS09090	COG0753	catalase activity
BIS30_RS09095	COG2814	Major facilitator Superfamily
BIS30_RS09100	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIS30_RS09105	COG1131	(ABC) transporter
BIS30_RS09125	COG1595	DNA-templated transcription, initiation
BIS30_RS09130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIS30_RS09135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIS30_RS09140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIS30_RS09145	COG4988	ABC transporter
BIS30_RS09150	COG1294	oxidase, subunit
BIS30_RS09155	COG1271	oxidase subunit
BIS30_RS09160	COG3493	citrate carrier protein
BIS30_RS09175	COG0726	polysaccharide deacetylase
BIS30_RS09190	COG3842	ATPase activity
BIS30_RS09195	COG2508	Transcriptional regulator
BIS30_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS09205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS09215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIS30_RS09225	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIS30_RS09240	COG4894	glucomannan catabolic process
BIS30_RS09245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_RS09250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS09260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BIS30_RS09265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BIS30_RS09270	COG2610	gluconate transmembrane transporter activity
BIS30_RS09280	COG0500	methyltransferase
BIS30_RS09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_RS09300	COG0693	protein deglycase activity
BIS30_RS09300	COG0753	catalase activity
BIS30_RS09305	COG2851	Citrate transporter
BIS30_RS09310	COG2323	membrane
BIS30_RS09320	COG2723	6-phospho-beta-galactosidase activity
BIS30_RS09325	COG1263	PTS System
BIS30_RS09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS09325	COG2190	(PTS) system
BIS30_RS09330	COG3711	transcriptional antiterminator
BIS30_RS09340	COG2270	Major facilitator Superfamily
BIS30_RS09345	COG0513	Belongs to the DEAD box helicase family
BIS30_RS09350	COG2755	lipolytic protein G-D-S-L family
BIS30_RS09350	COG3401	FG-GAP repeat protein
BIS30_RS09460	COG0697	spore germination
BIS30_RS09470	COG0861	Integral membrane protein TerC family
BIS30_RS09475	COG0589	response to stress
BIS30_RS09480	COG2723	6-phospho-beta-galactosidase activity
BIS30_RS09485	COG2190	(PTS) system
BIS30_RS09485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS09485	COG1263	PTS System
BIS30_RS09520	COG5444	nuclease activity
BIS30_RS09535	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_RS09540	COG0673	inositol 2-dehydrogenase activity
BIS30_RS09550	COG2986	histidine ammonia-lyase
BIS30_RS09555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BIS30_RS09560	COG1228	amidohydrolase
BIS30_RS09565	COG0010	Belongs to the arginase family
BIS30_RS09570	COG0833	amino acid
BIS30_RS09575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BIS30_RS09580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_RS09585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BIS30_RS09590	COG2390	Transcriptional regulator
BIS30_RS09600	COG3192	ethanolamine utilization protein
BIS30_RS09605	COG2079	MmgE PrpD family protein
BIS30_RS09610	COG1473	amidohydrolase
BIS30_RS09615	COG1126	abc transporter atp-binding protein
BIS30_RS09620	COG0765	amino acid transport
BIS30_RS09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_RS09630	COG0456	acetyltransferase
BIS30_RS09635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_RS09645	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BIS30_RS09650	COG0561	phosphatase activity
BIS30_RS09680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS09685	COG5294	Protein conserved in bacteria
BIS30_RS09690	COG0577	efflux transmembrane transporter activity
BIS30_RS09695	COG1136	(ABC) transporter
BIS30_RS09700	COG2205	protein histidine kinase activity
BIS30_RS09705	COG0745	RESPONSE REGULATOR receiver
BIS30_RS09710	COG0191	fructose-bisphosphate aldolase activity
BIS30_RS09715	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_RS09720	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_RS09725	COG0673	inositol 2-dehydrogenase activity
BIS30_RS09730	COG2814	Major facilitator Superfamily
BIS30_RS09735	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_RS09740	COG3962	Belongs to the TPP enzyme family
BIS30_RS09745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS09760	COG1349	DNA-binding transcription factor activity
BIS30_RS09765	COG0667	Aldo Keto reductase
BIS30_RS09780	COG2814	Major facilitator Superfamily
BIS30_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS09800	COG1309	transcriptional regulator
BIS30_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS09815	COG1714	RDD family
BIS30_RS09820	COG2311	Membrane
BIS30_RS09825	COG1917	Cupin 2, conserved barrel domain protein
BIS30_RS09830	COG1309	transcriptional regulator
BIS30_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS09840	COG1846	Transcriptional regulator
BIS30_RS09845	COG1380	Effector of murein hydrolase LrgA
BIS30_RS09850	COG1346	cytolysis
BIS30_RS09860	COG5039	Polysaccharide pyruvyl transferase
BIS30_RS09865	COG1929	Belongs to the glycerate kinase type-1 family
BIS30_RS09870	COG1802	Transcriptional regulator
BIS30_RS09875	COG1070	Carbohydrate kinase
BIS30_RS09880	COG2610	gluconate transmembrane transporter activity
BIS30_RS09885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIS30_RS09890	COG0450	alkyl hydroperoxide reductase
BIS30_RS09895	COG3634	alkyl hydroperoxide reductase activity
BIS30_RS09905	COG2723	6-phospho-beta-galactosidase activity
BIS30_RS09915	COG2188	Transcriptional regulator
BIS30_RS09925	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BIS30_RS09930	COG0270	DNA (cytosine-5-)-methyltransferase activity
BIS30_RS09955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIS30_RS09980	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BIS30_RS09985	COG0456	acetyltransferase
BIS30_RS09990	COG0457	Tetratricopeptide repeat
BIS30_RS10000	COG0010	Belongs to the arginase family
BIS30_RS10005	COG0833	amino acid
BIS30_RS10010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIS30_RS10015	COG3829	transcription factor binding
BIS30_RS10025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_RS10030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BIS30_RS10035	COG4853	Protein conserved in bacteria
BIS30_RS10040	COG4863	YycH protein
BIS30_RS10045	COG5002	protein histidine kinase activity
BIS30_RS10050	COG0745	RESPONSE REGULATOR receiver
BIS30_RS10080	COG0346	lactoylglutathione lyase activity
BIS30_RS10085	COG0305	Participates in initiation and elongation during chromosome replication
BIS30_RS10105	COG3093	addiction module antidote protein HigA
BIS30_RS10110	COG2807	transmembrane transport
BIS30_RS10115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BIS30_RS10120	COG0359	binds to the 23S rRNA
BIS30_RS10125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIS30_RS10130	COG4241	membrane
BIS30_RS10140	COG5577	PFAM Coat F domain
BIS30_RS10145	COG1733	regulation of RNA biosynthetic process
BIS30_RS10150	COG1227	inorganic diphosphatase activity
BIS30_RS10165	COG2271	Major facilitator Superfamily
BIS30_RS10180	COG2814	Major facilitator Superfamily
BIS30_RS10185	COG0583	DNA-binding transcription factor activity
BIS30_RS10190	COG2153	protein acetylation
BIS30_RS10200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS10215	COG1846	Transcriptional regulator
BIS30_RS10220	COG2153	protein acetylation
BIS30_RS10225	COG2364	Membrane
BIS30_RS10230	COG1331	Highly conserved protein containing a thioredoxin domain
BIS30_RS10235	COG1266	CAAX protease self-immunity
BIS30_RS10240	COG0477	Major facilitator Superfamily
BIS30_RS10240	COG2814	Major facilitator Superfamily
BIS30_RS10245	COG0110	maltose O-acetyltransferase activity
BIS30_RS10250	COG0346	lactoylglutathione lyase activity
BIS30_RS10255	COG1609	Transcriptional regulator
BIS30_RS10260	COG0708	Exodeoxyribonuclease III
BIS30_RS10265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIS30_RS10270	COG0629	single-stranded DNA binding
BIS30_RS10275	COG0360	Binds together with S18 to 16S ribosomal RNA
BIS30_RS10280	COG0012	GTP binding
BIS30_RS10285	COG0243	molybdopterin cofactor binding
BIS30_RS10290	COG4481	Protein conserved in bacteria
BIS30_RS10295	COG3949	Membrane
BIS30_RS10305	COG1475	DNA binding
BIS30_RS10310	COG1192	Involved in chromosome partitioning
BIS30_RS10320	COG1475	DNA binding
BIS30_RS10325	COG0357	Ribosomal RNA small subunit methyltransferase G
BIS30_RS10330	COG0445	tRNA wobble uridine modification
BIS30_RS10335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIS30_RS10340	COG1847	R3H domain protein
BIS30_RS10345	COG0706	membrane insertase activity
BIS30_RS10350	COG0594	ribonuclease P activity
BIS30_RS10360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIS30_RS10365	COG0592	DNA-directed DNA polymerase activity
BIS30_RS10370	COG2501	S4 domain
BIS30_RS10375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIS30_RS10385	COG0187	DNA topoisomerase II activity
BIS30_RS10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIS30_RS10425	COG0516	GMP reductase activity
BIS30_RS10425	COG0517	IMP dehydrogenase activity
BIS30_RS10430	COG1686	Belongs to the peptidase S11 family
BIS30_RS10435	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BIS30_RS10440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BIS30_RS10445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIS30_RS10455	COG1428	Deoxynucleoside kinase
BIS30_RS10460	COG1428	Deoxynucleoside kinase
BIS30_RS10465	COG1388	LysM domain
BIS30_RS10465	COG3858	chitin binding
BIS30_RS10470	COG1335	isochorismatase
BIS30_RS10475	COG0590	tRNA wobble adenosine to inosine editing
BIS30_RS10480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIS30_RS10485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIS30_RS10490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIS30_RS10535	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BIS30_RS10540	COG3853	Toxic anion resistance protein (TelA)
BIS30_RS10545	COG1982	Orn Lys Arg decarboxylase major
BIS30_RS10550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIS30_RS10555	COG3870	Protein conserved in bacteria
BIS30_RS10560	COG1728	Protein conserved in bacteria
BIS30_RS10565	COG0470	DNA polymerase III
BIS30_RS10570	COG1774	PSP1 C-terminal conserved region
BIS30_RS10575	COG4467	Involved in initiation control of chromosome replication
BIS30_RS10580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BIS30_RS10585	COG2827	Endonuclease containing a URI domain
BIS30_RS10590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIS30_RS10595	COG2002	toxin-antitoxin pair type II binding
BIS30_RS10600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_RS10600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_RS10605	COG0084	hydrolase, TatD family'
BIS30_RS10610	COG3583	domain protein
BIS30_RS10610	COG3584	3D domain protein
BIS30_RS10615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIS30_RS10620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIS30_RS10630	COG4466	Protein conserved in bacteria
BIS30_RS10640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIS30_RS10645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_RS10650	COG0251	oxidation-reduction process
BIS30_RS10655	COG2088	sporulation resulting in formation of a cellular spore
BIS30_RS10665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIS30_RS10670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIS30_RS10675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BIS30_RS10680	COG0193	aminoacyl-tRNA hydrolase activity
BIS30_RS10690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIS30_RS10695	COG2002	toxin-antitoxin pair type II binding
BIS30_RS10700	COG2244	polysaccharide biosynthetic process
BIS30_RS10705	COG3956	TIGRFAM MazG family protein
BIS30_RS10710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIS30_RS10725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BIS30_RS10730	COG1098	S1 RNA binding domain
BIS30_RS10745	COG2208	phosphoserine phosphatase activity
BIS30_RS10750	COG2304	oxidoreductase activity
BIS30_RS10755	COG0515	serine threonine protein kinase
BIS30_RS10765	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIS30_RS10770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIS30_RS10775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIS30_RS10780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIS30_RS10785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIS30_RS10790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_RS10795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIS30_RS10800	COG0512	Glutamine amidotransferase of anthranilate synthase
BIS30_RS10805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_RS10810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIS30_RS10815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIS30_RS10820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIS30_RS10825	COG1396	sequence-specific DNA binding
BIS30_RS10830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIS30_RS10835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIS30_RS10860	COG4463	regulation of RNA biosynthetic process
BIS30_RS10865	COG3880	PFAM UvrB UvrC protein
BIS30_RS10870	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BIS30_RS10875	COG0542	response to heat
BIS30_RS10880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIS30_RS10885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BIS30_RS10890	COG4956	integral membrane protein (PIN domain superfamily)
BIS30_RS10895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BIS30_RS10900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BIS30_RS10905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIS30_RS10915	COG1045	serine acetyltransferase
BIS30_RS10920	COG0215	cysteine-tRNA ligase activity
BIS30_RS10925	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BIS30_RS10930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIS30_RS10935	COG3688	RNA-binding protein containing a PIN domain
BIS30_RS10940	COG1595	DNA-templated transcription, initiation
BIS30_RS10950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIS30_RS10955	COG0250	Participates in transcription elongation, termination and antitermination
BIS30_RS10965	COG0081	regulation of translation
BIS30_RS10970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIS30_RS10980	COG2813	Specifically methylates the guanine in position
BIS30_RS10985	COG0085	RNA polymerase activity
BIS30_RS10990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIS30_RS10995	COG1358	cellular component organization or biogenesis
BIS30_RS11000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIS30_RS11005	COG0049	tRNA binding
BIS30_RS11010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIS30_RS11015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIS30_RS11020	COG0596	Alpha beta hydrolase
BIS30_RS11030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIS30_RS11035	COG0088	Forms part of the polypeptide exit tunnel
BIS30_RS11045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIS30_RS11065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIS30_RS11075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIS30_RS11080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIS30_RS11090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIS30_RS11100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIS30_RS11105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIS30_RS11110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIS30_RS11125	COG0200	Binds to the 23S rRNA
BIS30_RS11130	COG0201	protein transport
BIS30_RS11135	COG0563	adenylate kinase activity
BIS30_RS11140	COG0024	Methionine aminopeptidase
BIS30_RS11145	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BIS30_RS11155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIS30_RS11165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIS30_RS11170	COG0202	RNA polymerase activity
BIS30_RS11175	COG0203	ribosomal protein L17
BIS30_RS11180	COG1122	ATPase activity
BIS30_RS11185	COG1122	ATPase activity
BIS30_RS11190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIS30_RS11195	COG0101	tRNA pseudouridine synthase activity
BIS30_RS11215	COG2226	methyltransferase
BIS30_RS11225	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS11230	COG0489	protein tyrosine kinase activity
BIS30_RS11240	COG2194	sulfuric ester hydrolase activity
BIS30_RS11245	COG0726	polysaccharide deacetylase
BIS30_RS11315	COG0659	secondary active sulfate transmembrane transporter activity
BIS30_RS11320	COG0385	Bile acid
BIS30_RS11325	COG2819	hydrolase of the alpha beta superfamily
BIS30_RS11330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS11335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS11340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS11345	COG2207	Transcriptional regulator
BIS30_RS11345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS11350	COG3876	Protein conserved in bacteria
BIS30_RS11355	COG1472	Belongs to the glycosyl hydrolase 3 family
BIS30_RS11360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_RS11365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS11365	COG1263	PTS System
BIS30_RS11370	COG1737	Transcriptional regulator
BIS30_RS11375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIS30_RS11380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS11385	COG1683	Conserved Protein
BIS30_RS11415	COG1595	DNA-templated transcription, initiation
BIS30_RS11420	COG5662	AntiSigma factor
BIS30_RS11425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIS30_RS11430	COG4856	YbbR-like protein
BIS30_RS11435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIS30_RS11445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BIS30_RS11450	COG3002	Belongs to the UPF0753 family
BIS30_RS11465	COG5609	conserved protein (DUF2294)
BIS30_RS11470	COG0596	Alpha beta hydrolase
BIS30_RS11475	COG0745	RESPONSE REGULATOR receiver
BIS30_RS11480	COG0642	Histidine kinase
BIS30_RS11490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIS30_RS11500	COG2211	Major facilitator Superfamily
BIS30_RS11560	COG0515	serine threonine protein kinase
BIS30_RS11575	COG1113	amino acid transport
BIS30_RS11590	COG2602	Beta-lactamase
BIS30_RS11595	COG2124	cytochrome p450
BIS30_RS11605	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIS30_RS11610	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_RS11615	COG2271	Major facilitator Superfamily
BIS30_RS11625	COG0456	acetyltransferase
BIS30_RS11625	COG1846	Transcriptional regulator
BIS30_RS11630	COG2271	Major facilitator Superfamily
BIS30_RS11645	COG0697	spore germination
BIS30_RS11650	COG1917	Cupin 2, conserved barrel domain protein
BIS30_RS11650	COG2207	Transcriptional regulator
BIS30_RS11655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BIS30_RS11660	COG3591	Belongs to the peptidase S1B family
BIS30_RS11670	COG0596	Alpha beta hydrolase
BIS30_RS11675	COG1183	phosphatidylcholine synthase activity
BIS30_RS11680	COG0586	Pfam SNARE associated Golgi protein
BIS30_RS11685	COG0688	phosphatidylethanolamine metabolic process
BIS30_RS11695	COG2312	Erythromycin esterase
BIS30_RS11700	COG1054	Belongs to the UPF0176 family
BIS30_RS11705	COG1301	dicarboxylic acid transport
BIS30_RS11715	COG0363	glucosamine-6-phosphate deaminase activity
BIS30_RS11720	COG2188	Transcriptional regulator
BIS30_RS11730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_RS11735	COG0833	amino acid
BIS30_RS11740	COG2040	homocysteine
BIS30_RS11750	COG1115	amino acid carrier protein
BIS30_RS11755	COG2066	Belongs to the glutaminase family
BIS30_RS11760	COG4191	Histidine kinase
BIS30_RS11765	COG0784	Response regulator, receiver
BIS30_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS11780	COG2271	Major facilitator Superfamily
BIS30_RS11785	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_RS11790	COG2186	Transcriptional regulator
BIS30_RS11795	COG2721	sulfolactate sulfo-lyase activity
BIS30_RS11800	COG3173	Aminoglycoside phosphotransferase
BIS30_RS11810	COG0745	RESPONSE REGULATOR receiver
BIS30_RS11815	COG2205	protein histidine kinase activity
BIS30_RS11820	COG1131	(ABC) transporter
BIS30_RS11840	COG3773	Cell wall hydrolase
BIS30_RS11845	COG2304	oxidoreductase activity
BIS30_RS11855	COG3540	Alkaline phosphatase
BIS30_RS11860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIS30_RS11865	COG0805	protein transport
BIS30_RS11870	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIS30_RS11875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIS30_RS11880	COG0477	Major facilitator Superfamily
BIS30_RS11885	COG1309	transcriptional regulator
BIS30_RS11890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIS30_RS11895	COG1714	RDD family
BIS30_RS11900	COG1405	negative regulation of cell septum assembly
BIS30_RS11900	COG3012	SEC-C Motif Domain Protein
BIS30_RS11915	COG0667	Aldo Keto reductase
BIS30_RS11925	COG1595	DNA-templated transcription, initiation
BIS30_RS11950	COG1876	peptidase activity
BIS30_RS11955	COG0457	Tetratricopeptide repeat
BIS30_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS11965	COG0366	Alpha amylase catalytic
BIS30_RS11970	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIS30_RS11975	COG1121	(ABC) transporter
BIS30_RS11980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_RS11985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_RS11990	COG2310	stress, protein
BIS30_RS11995	COG2310	stress, protein
BIS30_RS12000	COG2310	stress, protein
BIS30_RS12005	COG0861	Integral membrane protein TerC family
BIS30_RS12015	COG3853	Toxic anion resistance protein (TelA)
BIS30_RS12020	COG0477	Major facilitator Superfamily
BIS30_RS12025	COG0640	Transcriptional regulator
BIS30_RS12030	COG0517	IMP dehydrogenase activity
BIS30_RS12030	COG4175	Glycine betaine
BIS30_RS12035	COG4176	ABC-type proline glycine betaine transport system permease component
BIS30_RS12040	COG2113	Glycine betaine
BIS30_RS12045	COG1473	amidohydrolase
BIS30_RS12050	COG1288	antiporter activity
BIS30_RS12065	COG0366	Alpha amylase catalytic
BIS30_RS12070	COG0039	L-malate dehydrogenase activity
BIS30_RS12075	COG1620	l-lactate permease
BIS30_RS12080	COG2814	Major facilitator Superfamily
BIS30_RS12085	COG1846	Transcriptional regulator
BIS30_RS12090	COG1280	lysine exporter protein (LysE YggA)
BIS30_RS12095	COG3403	YqcI/YcgG family
BIS30_RS12100	COG1113	amino acid transport
BIS30_RS12105	COG3665	Urea carboxylase-associated protein
BIS30_RS12110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIS30_RS12115	COG1660	Displays ATPase and GTPase activities
BIS30_RS12120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIS30_RS12125	COG2226	methyltransferase
BIS30_RS12130	COG0583	DNA-binding transcription factor activity
BIS30_RS12135	COG3458	cephalosporin-C deacetylase activity
BIS30_RS12140	COG3541	Predicted nucleotidyltransferase
BIS30_RS12145	COG0506	proline dehydrogenase activity
BIS30_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS12155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS12160	COG2508	Transcriptional regulator
BIS30_RS12165	COG3689	TIGRFAM TIGR03943 family protein
BIS30_RS12170	COG0701	Predicted permease
BIS30_RS12175	COG2267	carboxylic ester hydrolase activity
BIS30_RS12180	COG0492	ferredoxin-NADP+ reductase activity
BIS30_RS12185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BIS30_RS12185	COG1587	Uroporphyrinogen-III synthase
BIS30_RS12190	COG2146	nitrite reductase [NAD(P)H] activity
BIS30_RS12195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_RS12200	COG0243	molybdopterin cofactor binding
BIS30_RS12205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_RS12210	COG2223	nitrite transmembrane transporter activity
BIS30_RS12215	COG1469	GTP cyclohydrolase I activity
BIS30_RS12220	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_RS12220	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_RS12230	COG0523	cobalamin synthesis protein
BIS30_RS12235	COG0765	amino acid transport
BIS30_RS12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_RS12250	COG1714	RDD family
BIS30_RS12260	COG1846	Transcriptional regulator
BIS30_RS12270	COG3842	ATPase activity
BIS30_RS12275	COG2723	6-phospho-beta-galactosidase activity
BIS30_RS12285	COG3209	COG3209 Rhs family protein
BIS30_RS12295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BIS30_RS12300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BIS30_RS12305	COG1733	regulation of RNA biosynthetic process
BIS30_RS12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS12320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS12325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS12330	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BIS30_RS12335	COG2814	Major facilitator Superfamily
BIS30_RS12345	COG0697	spore germination
BIS30_RS12350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS12360	COG2364	Membrane
BIS30_RS12365	COG1126	abc transporter atp-binding protein
BIS30_RS12370	COG0765	amino acid transport
BIS30_RS12375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_RS12380	COG0583	DNA-binding transcription factor activity
BIS30_RS12385	COG0163	prenyltransferase activity
BIS30_RS12390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BIS30_RS12405	COG0596	Alpha beta hydrolase
BIS30_RS12410	COG3104	oligopeptide transport
BIS30_RS12415	COG5434	Belongs to the glycosyl hydrolase 28 family
BIS30_RS12425	COG0697	spore germination
BIS30_RS12435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIS30_RS12440	COG1136	(ABC) transporter
BIS30_RS12445	COG0577	efflux transmembrane transporter activity
BIS30_RS12450	COG0745	RESPONSE REGULATOR receiver
BIS30_RS12455	COG3850	Histidine kinase
BIS30_RS12455	COG5002	protein histidine kinase activity
BIS30_RS12460	COG0457	Tetratricopeptide repeat
BIS30_RS12475	COG0527	aspartate kinase activity
BIS30_RS12480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS12485	COG4605	iron ion homeostasis
BIS30_RS12490	COG4604	ABC transporter, ATP-binding protein
BIS30_RS12495	COG4607	ABC-type enterochelin transport system periplasmic component
BIS30_RS12500	COG2814	Major facilitator Superfamily
BIS30_RS12505	COG1309	transcriptional regulator
BIS30_RS12510	COG0778	Nitroreductase
BIS30_RS12515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BIS30_RS12520	COG0640	Transcriptional regulator
BIS30_RS12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS12530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIS30_RS12535	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS12540	COG4975	Glucose uptake
BIS30_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS12550	COG4549	nuclear export factor GLE1
BIS30_RS12555	COG2372	response to copper ion
BIS30_RS12555	COG1276	copper resistance
BIS30_RS12560	COG1349	DNA-binding transcription factor activity
BIS30_RS12570	COG2213	PTS system mannitol-specific
BIS30_RS12575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS12580	COG0246	Mannitol dehydrogenase
BIS30_RS12585	COG0473	3-isopropylmalate dehydrogenase activity
BIS30_RS12590	COG0681	Belongs to the peptidase S26 family
BIS30_RS12595	COG0412	Dienelactone hydrolase
BIS30_RS12600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIS30_RS12610	COG0561	phosphatase activity
BIS30_RS12615	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BIS30_RS12620	COG1914	H( )-stimulated, divalent metal cation uptake system
BIS30_RS12625	COG4336	lyase activity
BIS30_RS12630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BIS30_RS12635	COG1984	allophanate hydrolase subunit 2
BIS30_RS12640	COG1414	Transcriptional regulator
BIS30_RS12645	COG2755	lipolytic protein G-D-S-L family
BIS30_RS12655	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_RS12660	COG0768	penicillin binding
BIS30_RS12665	COG4989	oxidoreductase activity
BIS30_RS12670	COG3711	transcriptional antiterminator
BIS30_RS12675	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS12680	COG2226	methyltransferase
BIS30_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS12690	COG1917	Cupin 2, conserved barrel domain protein
BIS30_RS12695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS12700	COG3871	stress protein (general stress protein 26)
BIS30_RS12710	COG2814	Major facilitator Superfamily
BIS30_RS12715	COG1522	sequence-specific DNA binding
BIS30_RS12720	COG0551	DNA topoisomerase type I activity
BIS30_RS12720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIS30_RS12725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BIS30_RS12730	COG3706	GGDEF domain
BIS30_RS12735	COG5298	Protein conserved in bacteria
BIS30_RS12740	COG1215	transferase activity, transferring glycosyl groups
BIS30_RS12750	COG0531	amino acid
BIS30_RS12755	COG0494	nUDIX hydrolase
BIS30_RS12760	COG0028	Belongs to the TPP enzyme family
BIS30_RS12770	COG1914	H( )-stimulated, divalent metal cation uptake system
BIS30_RS12775	COG2261	transglycosylase associated protein
BIS30_RS12780	COG4876	unkown
BIS30_RS12785	COG2217	Heavy metal translocating P-type atpase
BIS30_RS12790	COG3729	General stress protein
BIS30_RS12800	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_RS12805	COG3546	catalase activity
BIS30_RS12810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BIS30_RS12815	COG3290	protein histidine kinase activity
BIS30_RS12820	COG4565	transcriptional regulatory protein
BIS30_RS12825	COG1301	dicarboxylic acid transport
BIS30_RS12830	COG0628	permease
BIS30_RS12835	COG1301	dicarboxylic acid transport
BIS30_RS12840	COG1131	(ABC) transporter
BIS30_RS12845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIS30_RS12855	COG1960	acyl-CoA dehydrogenase activity
BIS30_RS12870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_RS12875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS12880	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIS30_RS12885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIS30_RS12890	COG0513	Belongs to the DEAD box helicase family
BIS30_RS12895	COG3402	PFAM membrane-flanked domain
BIS30_RS12900	COG3428	Bacterial PH domain
BIS30_RS12905	COG0705	Rhomboid family
BIS30_RS12910	COG0736	holo-[acyl-carrier-protein] synthase activity
BIS30_RS12915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BIS30_RS12920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIS30_RS12925	COG0864	Transcriptional regulator
BIS30_RS12930	COG2337	Toxic component of a toxin-antitoxin (TA) module
BIS30_RS12935	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS12940	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS12945	COG2172	sigma factor antagonist activity
BIS30_RS12950	COG2208	phosphoserine phosphatase activity
BIS30_RS12955	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS12960	COG2172	sigma factor antagonist activity
BIS30_RS12965	COG1191	sigma factor activity
BIS30_RS12970	COG2208	phosphoserine phosphatase activity
BIS30_RS12975	COG2183	response to ionizing radiation
BIS30_RS12985	COG3091	SprT-like family
BIS30_RS13030	COG0789	Transcriptional regulator
BIS30_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS13040	COG0667	Aldo Keto reductase
BIS30_RS13045	COG4221	oxidoreductase activity
BIS30_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS13060	COG4221	oxidoreductase activity
BIS30_RS13065	COG3239	Fatty acid desaturase
BIS30_RS13070	COG1278	Cold shock
BIS30_RS13075	COG1329	Transcriptional regulator
BIS30_RS13085	COG1396	sequence-specific DNA binding
BIS30_RS13090	COG2207	Transcriptional regulator
BIS30_RS13090	COG3708	Transcriptional regulator
BIS30_RS13100	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BIS30_RS13115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIS30_RS13120	COG1522	sequence-specific DNA binding
BIS30_RS13125	COG0697	spore germination
BIS30_RS13130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS13135	COG2030	dehydratase
BIS30_RS13140	COG3545	Serine hydrolase
BIS30_RS13145	COG1733	regulation of RNA biosynthetic process
BIS30_RS13150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS13160	COG0640	Transcriptional regulator
BIS30_RS13165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIS30_RS13170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_RS13175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS13180	COG0697	spore germination
BIS30_RS13185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS13190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIS30_RS13195	COG0640	Transcriptional regulator
BIS30_RS13200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIS30_RS13215	COG4585	Histidine kinase
BIS30_RS13220	COG2197	response regulator
BIS30_RS13225	COG2409	Drug exporters of the RND superfamily
BIS30_RS13240	COG1114	Component of the transport system for branched-chain amino acids
BIS30_RS13250	COG1811	Na channel or pump
BIS30_RS13255	COG0789	Transcriptional regulator
BIS30_RS13255	COG4978	Transcriptional regulator
BIS30_RS13260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_RS13265	COG0778	Nitroreductase
BIS30_RS13270	COG0346	lactoylglutathione lyase activity
BIS30_RS13275	COG2259	Doxx family
BIS30_RS13280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS13305	COG2323	membrane
BIS30_RS13310	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_RS13325	COG1309	transcriptional regulator
BIS30_RS13335	COG0456	acetyltransferase
BIS30_RS13345	COG0673	inositol 2-dehydrogenase activity
BIS30_RS13350	COG1609	Transcriptional regulator
BIS30_RS13370	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_RS13375	COG2814	Major facilitator Superfamily
BIS30_RS13385	COG0488	(ABC) transporter
BIS30_RS13390	COG1113	amino acid transport
BIS30_RS13395	COG2318	DinB family
BIS30_RS13400	COG1846	Transcriptional regulator
BIS30_RS13405	COG1033	growth of symbiont in host cell
BIS30_RS13405	COG2409	Drug exporters of the RND superfamily
BIS30_RS13410	COG0778	Nitroreductase
BIS30_RS13415	COG1846	Transcriptional regulator
BIS30_RS13420	COG1396	sequence-specific DNA binding
BIS30_RS13435	COG2814	Major facilitator Superfamily
BIS30_RS13440	COG0730	response to heat
BIS30_RS13445	COG1802	Transcriptional regulator
BIS30_RS13450	COG3858	chitin binding
BIS30_RS13450	COG1388	LysM domain
BIS30_RS13455	COG1819	glycosyl
BIS30_RS13470	COG1785	Belongs to the alkaline phosphatase family
BIS30_RS13485	COG1078	dGTPase activity
BIS30_RS13490	COG1388	LysM domain
BIS30_RS13495	COG2814	Major facilitator Superfamily
BIS30_RS13500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_RS13505	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIS30_RS13510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_RS13515	COG2723	6-phospho-beta-galactosidase activity
BIS30_RS13520	COG2188	Transcriptional regulator
BIS30_RS13525	COG1940	carbohydrate kinase activity
BIS30_RS13530	COG1482	cell wall glycoprotein biosynthetic process
BIS30_RS13535	COG4124	Belongs to the glycosyl hydrolase 26 family
BIS30_RS13580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BIS30_RS13585	COG0802	atpase or kinase
BIS30_RS13590	COG1214	PFAM Peptidase M22, glycoprotease
BIS30_RS13595	COG0456	acetyltransferase
BIS30_RS13600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIS30_RS13605	COG0488	(ABC) transporter
BIS30_RS13610	COG0315	cyclic pyranopterin monophosphate synthase activity
BIS30_RS13615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIS30_RS13620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIS30_RS13625	COG0805	protein transport
BIS30_RS13635	COG1266	CAAX protease self-immunity
BIS30_RS13645	COG0459	protein refolding
BIS30_RS13650	COG1073	alpha beta
BIS30_RS13655	COG0457	Tetratricopeptide repeat
BIS30_RS13660	COG1063	alcohol dehydrogenase
BIS30_RS13665	COG2211	Major facilitator Superfamily
BIS30_RS13670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_RS13675	COG1842	Phage shock protein A
BIS30_RS13680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIS30_RS13685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BIS30_RS13690	COG4260	virion core protein, lumpy skin disease virus
BIS30_RS13700	COG2814	Major facilitator Superfamily
BIS30_RS13705	COG1063	alcohol dehydrogenase
BIS30_RS13710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BIS30_RS13715	COG0823	Involved in the tonB-independent uptake of proteins
BIS30_RS13740	COG2267	carboxylic ester hydrolase activity
BIS30_RS13750	COG2132	Multicopper oxidase
BIS30_RS13755	COG1113	amino acid transport
BIS30_RS13765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_RS13770	COG0714	Associated with various cellular activities
BIS30_RS13775	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BIS30_RS13780	COG1305	Transglutaminase-like
BIS30_RS13790	COG2252	PERMEase
BIS30_RS13795	COG3064	Membrane
BIS30_RS13805	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BIS30_RS13815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIS30_RS13820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIS30_RS13825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIS30_RS13830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BIS30_RS13835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIS30_RS13840	COG0047	phosphoribosylformylglycinamidine synthase activity
BIS30_RS13845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIS30_RS13850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIS30_RS13855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIS30_RS13860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIS30_RS13865	COG0138	bifunctional purine biosynthesis protein purh
BIS30_RS13870	COG0151	Belongs to the GarS family
BIS30_RS13875	COG1522	sequence-specific DNA binding
BIS30_RS13880	COG0531	amino acid
BIS30_RS13890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIS30_RS13895	COG1470	cell adhesion involved in biofilm formation
BIS30_RS13900	COG4496	protein, YerC YecD
BIS30_RS13905	COG0069	glutamate synthase activity
BIS30_RS13910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BIS30_RS13915	COG0210	DNA helicase
BIS30_RS13920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIS30_RS13935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_RS13940	COG1285	pathogenesis
BIS30_RS13945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS13950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIS30_RS13955	COG0154	amidase activity
BIS30_RS13960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIS30_RS13965	COG1309	transcriptional regulator
BIS30_RS13970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIS30_RS13975	COG1597	lipid kinase activity
BIS30_RS13980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIS30_RS13985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BIS30_RS13990	COG0732	type I restriction modification DNA specificity domain
BIS30_RS13995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIS30_RS14015	COG5444	nuclease activity
BIS30_RS14020	COG3391	amine dehydrogenase activity
BIS30_RS14025	COG0457	Tetratricopeptide repeat
BIS30_RS14035	COG0217	transcriptional regulatory protein
BIS30_RS14045	COG1309	transcriptional regulator
BIS30_RS14050	COG3631	Ketosteroid isomerase-related protein
BIS30_RS14055	COG0702	epimerase
BIS30_RS14060	COG2159	amidohydrolase
BIS30_RS14065	COG1309	transcriptional regulator
BIS30_RS14080	COG3546	catalase activity
BIS30_RS14085	COG0454	-acetyltransferase
BIS30_RS14095	COG5578	integral membrane protein
BIS30_RS14100	COG2972	Histidine kinase
BIS30_RS14105	COG2207	Transcriptional regulator
BIS30_RS14105	COG4753	response regulator
BIS30_RS14110	COG1653	transport
BIS30_RS14115	COG1175	transmembrane transport
BIS30_RS14120	COG0395	ABC-type sugar transport system, permease component
BIS30_RS14125	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BIS30_RS14130	COG2207	Transcriptional regulator
BIS30_RS14135	COG2755	lipolytic protein G-D-S-L family
BIS30_RS14145	COG5578	integral membrane protein
BIS30_RS14150	COG3401	FG-GAP repeat protein
BIS30_RS14155	COG3401	FG-GAP repeat protein
BIS30_RS14160	COG2755	lipolytic protein G-D-S-L family
BIS30_RS14165	COG1874	Beta-galactosidase
BIS30_RS14175	COG1653	transport
BIS30_RS14180	COG4209	transmembrane transport
BIS30_RS14185	COG0395	ABC-type sugar transport system, permease component
BIS30_RS14190	COG1486	melibiose metabolic process
BIS30_RS14195	COG2323	membrane
BIS30_RS14200	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_RS14205	COG0346	lactoylglutathione lyase activity
BIS30_RS14215	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS14220	COG5583	Uncharacterized small protein (DUF2292)
BIS30_RS14225	COG0670	Belongs to the BI1 family
BIS30_RS14230	COG1846	Transcriptional regulator
BIS30_RS14235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIS30_RS14245	COG2124	cytochrome p450
BIS30_RS14245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_RS14250	COG1368	sulfuric ester hydrolase activity
BIS30_RS14255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BIS30_RS14260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_RS14265	COG1442	glycosyl transferase family 8
BIS30_RS14270	COG1216	Glycosyl transferase, family 2
BIS30_RS14275	COG1442	glycosyl transferase family 8
BIS30_RS14280	COG2223	nitrite transmembrane transporter activity
BIS30_RS14285	COG1011	Hydrolase
BIS30_RS14290	COG0531	amino acid
BIS30_RS14295	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_RS14300	COG0840	transmembrane signaling receptor activity
BIS30_RS14305	COG0488	(ABC) transporter
BIS30_RS14315	COG0789	Transcriptional regulator
BIS30_RS14320	COG2814	Major facilitator Superfamily
BIS30_RS14335	COG0488	(ABC) transporter
BIS30_RS14340	COG0513	Belongs to the DEAD box helicase family
BIS30_RS14345	COG0456	acetyltransferase
BIS30_RS14350	COG2130	NADP-dependent
BIS30_RS14355	COG1120	ATPase activity
BIS30_RS14360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS14365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS14370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BIS30_RS14385	COG3866	Pectate lyase
BIS30_RS14390	COG0471	metal ion transport
BIS30_RS14395	COG3290	protein histidine kinase activity
BIS30_RS14400	COG4565	transcriptional regulatory protein
BIS30_RS14405	COG3181	Tripartite tricarboxylate transporter family receptor
BIS30_RS14410	COG2851	Citrate transporter
BIS30_RS14415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS14420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BIS30_RS14425	COG1254	Belongs to the acylphosphatase family
BIS30_RS14430	COG2258	MOSC domain
BIS30_RS14450	COG0024	Methionine aminopeptidase
BIS30_RS14455	COG1263	PTS System
BIS30_RS14455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS14460	COG1368	sulfuric ester hydrolase activity
BIS30_RS14470	COG1115	amino acid carrier protein
BIS30_RS14475	COG0531	amino acid
BIS30_RS14490	COG0697	spore germination
BIS30_RS14495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS14495	COG1263	PTS System
BIS30_RS14500	COG0366	Alpha amylase catalytic
BIS30_RS14505	COG2188	Transcriptional regulator
BIS30_RS14510	COG0778	Nitroreductase
BIS30_RS14515	COG0737	Belongs to the 5'-nucleotidase family
BIS30_RS14520	COG0693	protein deglycase activity
BIS30_RS14525	COG2814	Major facilitator Superfamily
BIS30_RS14530	COG4840	Belongs to the UPF0435 family
BIS30_RS14535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_RS14540	COG4980	gas vesicle protein
BIS30_RS14545	COG1295	ribonuclease BN
BIS30_RS14555	COG0477	Major facilitator Superfamily
BIS30_RS14565	COG0387	Pfam Sodium calcium exchanger
BIS30_RS14575	COG0668	transmembrane transport
BIS30_RS14580	COG0535	radical SAM domain protein
BIS30_RS14590	COG0726	polysaccharide deacetylase
BIS30_RS14595	COG2084	Dehydrogenase
BIS30_RS14600	COG0598	Magnesium transport protein CorA
BIS30_RS14605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIS30_RS14615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIS30_RS14620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIS30_RS14630	COG4637	Psort location Cytoplasmic, score
BIS30_RS14640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_RS14645	COG0022	dehydrogenase e1 component
BIS30_RS14655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_RS14660	COG3284	Transcriptional regulator
BIS30_RS14670	COG1742	UPF0060 membrane protein
BIS30_RS14690	COG4842	Belongs to the WXG100 family
BIS30_RS14695	COG1486	melibiose metabolic process
BIS30_RS14700	COG1737	Transcriptional regulator
BIS30_RS14705	COG1263	PTS System
BIS30_RS14705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS14715	COG1132	(ABC) transporter
BIS30_RS14720	COG2259	Doxx family
BIS30_RS14725	COG2514	catechol 2,3-dioxygenase activity
BIS30_RS14730	COG4585	Histidine kinase
BIS30_RS14735	COG2197	response regulator
BIS30_RS14740	COG1131	(ABC) transporter
BIS30_RS14745	COG1511	domain protein
BIS30_RS14745	COG0842	Transport permease protein
BIS30_RS14750	COG0842	Transport permease protein
BIS30_RS14760	COG1695	Transcriptional regulator
BIS30_RS14765	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIS30_RS14770	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BIS30_RS14775	COG2318	DinB family
BIS30_RS14780	COG2814	Major facilitator Superfamily
BIS30_RS14785	COG1846	Transcriptional regulator
BIS30_RS14790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIS30_RS14790	COG0392	lysyltransferase activity
BIS30_RS14795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_RS14800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS14805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_RS14815	COG0778	Nitroreductase
BIS30_RS14830	COG1090	epimerase
BIS30_RS14835	COG2137	regulation of response to DNA damage stimulus
BIS30_RS14850	COG2814	Major facilitator Superfamily
BIS30_RS14865	COG3103	Sh3 type 3 domain protein
BIS30_RS14870	COG5658	integral membrane protein
BIS30_RS14875	COG0596	Alpha beta hydrolase
BIS30_RS14880	COG0463	Glycosyl transferase, family 2
BIS30_RS14885	COG4485	Bacterial membrane protein, YfhO
BIS30_RS14890	COG1988	membrane-bound metal-dependent
BIS30_RS14895	COG1194	a g-specific adenine glycosylase
BIS30_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS14920	COG3557	Belongs to the UPF0374 family
BIS30_RS14925	COG1132	(ABC) transporter
BIS30_RS14930	COG4129	membrane
BIS30_RS14935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIS30_RS14940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BIS30_RS14945	COG0735	belongs to the Fur family
BIS30_RS15065	COG4326	sporulation control protein
BIS30_RS15075	COG5577	PFAM Coat F domain
BIS30_RS15080	COG3340	Belongs to the peptidase S51 family
BIS30_RS15085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BIS30_RS15095	COG0753	catalase activity
BIS30_RS15100	COG1116	anion transmembrane transporter activity
BIS30_RS15105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIS30_RS15110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIS30_RS15115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_RS15125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIS30_RS15135	COG1476	TRANSCRIPTIONal
BIS30_RS15145	COG3382	B3 4 domain protein
BIS30_RS15150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BIS30_RS15160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIS30_RS15165	COG0789	Transcriptional regulator
BIS30_RS15170	COG1664	Polymer-forming cytoskeletal
BIS30_RS15175	COG1664	Polymer-forming cytoskeletal
BIS30_RS15180	COG2766	serine protein kinase
BIS30_RS15185	COG2718	Belongs to the UPF0229 family
BIS30_RS15190	COG1846	Transcriptional regulator
BIS30_RS15195	COG1566	PFAM secretion protein HlyD family protein
BIS30_RS15200	COG2814	Major facilitator Superfamily
BIS30_RS15205	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIS30_RS15220	COG1725	Transcriptional regulator
BIS30_RS15225	COG1131	(ABC) transporter
BIS30_RS15230	COG1131	(ABC) transporter
BIS30_RS15240	COG1278	Cold shock
BIS30_RS15245	COG1464	Belongs to the NlpA lipoprotein family
BIS30_RS15250	COG3706	GGDEF domain
BIS30_RS15255	COG1823	symporter activity
BIS30_RS15275	COG5577	PFAM Coat F domain
BIS30_RS15280	COG4085	toxin activity
BIS30_RS15280	COG1525	nuclease
BIS30_RS15280	COG0737	Belongs to the 5'-nucleotidase family
BIS30_RS15285	COG3764	Sortase (surface protein transpeptidase)
BIS30_RS15290	COG0564	pseudouridine synthase activity
BIS30_RS15300	COG0517	IMP dehydrogenase activity
BIS30_RS15305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIS30_RS15310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIS30_RS15310	COG3153	acetyltransferase
BIS30_RS15320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIS30_RS15325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIS30_RS15330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIS30_RS15335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIS30_RS15340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BIS30_RS15345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIS30_RS15350	COG2203	Gaf domain
BIS30_RS15350	COG4585	Histidine kinase
BIS30_RS15355	COG2197	response regulator
BIS30_RS15360	COG0431	NADPH-dependent FMN reductase
BIS30_RS15375	COG1388	LysM domain
BIS30_RS15375	COG0791	NLP P60 protein
BIS30_RS15380	COG1959	2 iron, 2 sulfur cluster binding
BIS30_RS15385	COG0668	transmembrane transport
BIS30_RS15390	COG2719	SpoVR family
BIS30_RS15395	COG1785	Belongs to the alkaline phosphatase family
BIS30_RS15400	COG0791	NLP P60 protein
BIS30_RS15400	COG1388	LysM domain
BIS30_RS15405	COG0583	DNA-binding transcription factor activity
BIS30_RS15410	COG0372	Belongs to the citrate synthase family
BIS30_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS15420	COG0531	amino acid
BIS30_RS15425	COG0733	neurotransmitter:sodium symporter activity
BIS30_RS15430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS15435	COG0456	acetyltransferase
BIS30_RS15450	COG1595	DNA-templated transcription, initiation
BIS30_RS15455	COG0667	Aldo Keto reductase
BIS30_RS15460	COG0204	Acyl-transferase
BIS30_RS15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_RS15475	COG1253	flavin adenine dinucleotide binding
BIS30_RS15480	COG0789	Transcriptional regulator
BIS30_RS15485	COG0436	Aminotransferase
BIS30_RS15490	COG1253	flavin adenine dinucleotide binding
BIS30_RS15495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIS30_RS15500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIS30_RS15505	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_RS15515	COG0668	transmembrane transport
BIS30_RS15520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIS30_RS15525	COG0726	polysaccharide deacetylase
BIS30_RS15530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_RS15535	COG1757	Na H antiporter
BIS30_RS15540	COG0589	response to stress
BIS30_RS15550	COG1132	(ABC) transporter
BIS30_RS15555	COG1132	(ABC) transporter
BIS30_RS15560	COG0702	epimerase
BIS30_RS15585	COG0189	ligase activity
BIS30_RS15590	COG4399	Belongs to the UPF0754 family
BIS30_RS15595	COG3679	Belongs to the UPF0342 family
BIS30_RS15600	COG4335	DNA alkylation repair
BIS30_RS15610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIS30_RS15615	COG0475	glutathione-regulated potassium exporter activity
BIS30_RS15620	COG0490	domain, Protein
BIS30_RS15630	COG1024	Enoyl-CoA hydratase
BIS30_RS15640	COG4152	abc transporter atp-binding protein
BIS30_RS15645	COG1668	transmembrane transport
BIS30_RS15650	COG0420	3'-5' exonuclease activity
BIS30_RS15655	COG4717	serine-type aminopeptidase activity
BIS30_RS15660	COG3481	metal-dependent phosphohydrolase, HD sub domain
BIS30_RS15670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIS30_RS15695	COG1846	Transcriptional regulator
BIS30_RS15700	COG4980	gas vesicle protein
BIS30_RS15715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIS30_RS15720	COG0537	adenosine 5'-monophosphoramidase activity
BIS30_RS15725	COG1131	(ABC) transporter
BIS30_RS15730	COG4473	ABC transporter
BIS30_RS15740	COG1473	amidohydrolase
BIS30_RS15745	COG3069	C4-dicarboxylate transmembrane transporter activity
BIS30_RS15755	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_RS15760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_RS15765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BIS30_RS15770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BIS30_RS15775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIS30_RS15780	COG1309	transcriptional regulator
BIS30_RS15785	COG1511	domain protein
BIS30_RS15790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIS30_RS15795	COG4377	Putative membrane peptidase family (DUF2324)
BIS30_RS15805	COG1363	Peptidase, m42
BIS30_RS15810	COG4405	Protein conserved in bacteria
BIS30_RS15815	COG1301	dicarboxylic acid transport
BIS30_RS15825	COG1234	tRNA 3'-trailer cleavage
BIS30_RS15830	COG0095	Lipoate-protein ligase
BIS30_RS15835	COG0702	epimerase
BIS30_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS15850	COG0501	Belongs to the peptidase M48B family
BIS30_RS15860	COG0456	acetyltransferase
BIS30_RS15865	COG0604	alcohol dehydrogenase
BIS30_RS15870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BIS30_RS15875	COG0406	alpha-ribazole phosphatase activity
BIS30_RS15880	COG0183	Belongs to the thiolase family
BIS30_RS15885	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS15890	COG1268	BioY protein
BIS30_RS15895	COG0840	transmembrane signaling receptor activity
BIS30_RS15900	COG0723	plastoquinol--plastocyanin reductase activity
BIS30_RS15900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS15915	COG4903	ComK protein
BIS30_RS15920	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS15930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_RS15945	COG0398	Pfam SNARE associated Golgi protein
BIS30_RS15950	COG0681	Belongs to the peptidase S26 family
BIS30_RS15955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIS30_RS15960	COG1846	Transcriptional regulator
BIS30_RS15970	COG0738	Major facilitator superfamily
BIS30_RS15975	COG0673	inositol 2-dehydrogenase activity
BIS30_RS15980	COG0561	phosphatase activity
BIS30_RS15985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_RS15990	COG1609	Transcriptional regulator
BIS30_RS15995	COG3180	Ammonia monooxygenase
BIS30_RS16000	COG0477	Major facilitator Superfamily
BIS30_RS16000	COG2814	Major facilitator Superfamily
BIS30_RS16005	COG4533	DNA binding
BIS30_RS16015	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BIS30_RS16020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BIS30_RS16025	COG1074	ATP-dependent DNA helicase activity
BIS30_RS16030	COG0420	3'-5' exonuclease activity
BIS30_RS16035	COG0419	ATPase involved in DNA repair
BIS30_RS16040	COG1403	HNH endonuclease
BIS30_RS16080	COG5337	Spore coat protein CotH
BIS30_RS16085	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIS30_RS16095	COG1404	Belongs to the peptidase S8 family
BIS30_RS16105	COG0367	asparagine synthase
BIS30_RS16110	COG2318	DinB family
BIS30_RS16115	COG1562	ergosterol biosynthetic process
BIS30_RS16120	COG0534	Mate efflux family protein
BIS30_RS16125	COG2207	Transcriptional regulator
BIS30_RS16125	COG1917	Cupin 2, conserved barrel domain protein
BIS30_RS16130	COG1609	Transcriptional regulator
BIS30_RS16135	COG0673	inositol 2-dehydrogenase activity
BIS30_RS16140	COG2318	DinB family
BIS30_RS16145	COG1279	arginine transmembrane transporter activity
BIS30_RS16150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_RS16155	COG1357	PFAM Pentapeptide repeats (8 copies)
BIS30_RS16160	COG2267	carboxylic ester hydrolase activity
BIS30_RS16165	COG0529	Catalyzes the synthesis of activated sulfate
BIS30_RS16170	COG2046	Belongs to the sulfate adenylyltransferase family
BIS30_RS16175	COG0175	sulfate reduction
BIS30_RS16180	COG2045	Belongs to the ComB family
BIS30_RS16185	COG1809	phosphosulfolactate synthase activity
BIS30_RS16190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS16195	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_RS16200	COG2814	Major facilitator Superfamily
BIS30_RS16205	COG0454	-acetyltransferase
BIS30_RS16210	COG2153	protein acetylation
BIS30_RS16215	COG0646	methionine synthase
BIS30_RS16215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIS30_RS16220	COG1666	GTP binding
BIS30_RS16225	COG2996	Protein conserved in bacteria
BIS30_RS16235	COG1307	EDD domain protein, DegV family
BIS30_RS16240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_RS16260	COG0561	phosphatase activity
BIS30_RS16265	COG1073	alpha beta
BIS30_RS16270	COG2151	metal-sulfur cluster biosynthetic enzyme
BIS30_RS16280	COG0277	FAD linked oxidase domain protein
BIS30_RS16285	COG2271	Major facilitator Superfamily
BIS30_RS16290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIS30_RS16295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIS30_RS16305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIS30_RS16310	COG0505	Belongs to the CarA family
BIS30_RS16315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIS30_RS16320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIS30_RS16335	COG2267	carboxylic ester hydrolase activity
BIS30_RS16345	COG1744	ABC transporter substrate-binding protein PnrA-like
BIS30_RS16365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIS30_RS16370	COG5504	Zn-dependent protease
BIS30_RS16375	COG0444	Belongs to the ABC transporter superfamily
BIS30_RS16380	COG4608	Belongs to the ABC transporter superfamily
BIS30_RS16390	COG0601	transmembrane transport
BIS30_RS16395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_RS16405	COG0180	Tryptophanyl-tRNA synthetase
BIS30_RS16410	COG4166	transmembrane transport
BIS30_RS16415	COG0601	transmembrane transport
BIS30_RS16420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_RS16425	COG0444	Belongs to the ABC transporter superfamily
BIS30_RS16430	COG4608	Belongs to the ABC transporter superfamily
BIS30_RS16435	COG2814	Major facilitator Superfamily
BIS30_RS16440	COG0456	acetyltransferase
BIS30_RS16445	COG1393	Belongs to the ArsC family
BIS30_RS16450	COG0861	Integral membrane protein TerC family
BIS30_RS16455	COG4862	establishment of competence for transformation
BIS30_RS16460	COG4469	Competence protein
BIS30_RS16465	COG1164	Oligoendopeptidase f
BIS30_RS16480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIS30_RS16485	COG2346	COG2346, Truncated hemoglobins
BIS30_RS16490	COG0741	lytic transglycosylase activity
BIS30_RS16495	COG4116	CYTH
BIS30_RS16505	COG2357	RelA SpoT domain protein
BIS30_RS16510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIS30_RS16515	COG0564	pseudouridine synthase activity
BIS30_RS16520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIS30_RS16525	COG0569	domain protein
BIS30_RS16525	COG0475	glutathione-regulated potassium exporter activity
BIS30_RS16530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIS30_RS16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_RS16545	COG2104	thiamine diphosphate biosynthetic process
BIS30_RS16550	COG2022	thiamine diphosphate biosynthetic process
BIS30_RS16555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIS30_RS16560	COG0351	phosphomethylpyrimidine kinase
BIS30_RS16565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIS30_RS16625	COG0210	DNA helicase
BIS30_RS16635	COG2153	protein acetylation
BIS30_RS16640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BIS30_RS16645	COG2382	esterase
BIS30_RS16650	COG0626	cystathionine gamma-synthase activity
BIS30_RS16655	COG0626	cystathionine gamma-synthase activity
BIS30_RS16665	COG5505	Protein of unknown function (DUF819)
BIS30_RS16690	COG0457	Tetratricopeptide repeat
BIS30_RS16720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_RS16720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS16720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_RS16725	COG1482	cell wall glycoprotein biosynthetic process
BIS30_RS16745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIS30_RS16765	COG0109	protoheme IX farnesyltransferase activity
BIS30_RS16775	COG0726	polysaccharide deacetylase
BIS30_RS16795	COG5504	Zn-dependent protease
BIS30_RS16800	COG2205	protein histidine kinase activity
BIS30_RS16810	COG3383	formate dehydrogenase (NAD+) activity
BIS30_RS16815	COG2427	Protein of unknown function (DUF1641)
BIS30_RS16825	COG1051	belongs to the nudix hydrolase family
BIS30_RS16835	COG2124	cytochrome p450
BIS30_RS16840	COG1819	glycosyl
BIS30_RS16850	COG1587	Uroporphyrinogen-III synthase
BIS30_RS16855	COG0390	transport system, permease component
BIS30_RS16860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_RS16865	COG0697	spore germination
BIS30_RS16870	COG4297	protein containing double-stranded beta helix domain
BIS30_RS16880	COG1252	NADH dehydrogenase
BIS30_RS16885	COG1904	glucuronate isomerase
BIS30_RS16890	COG2211	Major facilitator Superfamily
BIS30_RS16895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BIS30_RS16900	COG1063	alcohol dehydrogenase
BIS30_RS16905	COG1312	Catalyzes the dehydration of D-mannonate
BIS30_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS16915	COG2271	Major facilitator Superfamily
BIS30_RS16920	COG1609	Transcriptional regulator
BIS30_RS16925	COG0246	Mannitol dehydrogenase
BIS30_RS16930	COG2721	sulfolactate sulfo-lyase activity
BIS30_RS16935	COG0730	response to heat
BIS30_RS16940	COG2318	DinB family
BIS30_RS16945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIS30_RS16950	COG0457	Tetratricopeptide repeat
BIS30_RS16960	COG2350	Protein conserved in bacteria
BIS30_RS16965	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS16965	COG1388	LysM domain
BIS30_RS16965	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS16975	COG4195	phage-related replication protein
BIS30_RS16980	COG3546	catalase activity
BIS30_RS16985	COG2856	Zn peptidase
BIS30_RS16990	COG1396	sequence-specific DNA binding
BIS30_RS17000	COG1522	sequence-specific DNA binding
BIS30_RS17005	COG1484	DNA-dependent DNA replication
BIS30_RS17030	COG1595	DNA-templated transcription, initiation
BIS30_RS17035	COG5484	DNA packaging
BIS30_RS17035	COG3728	DNA packaging
BIS30_RS17045	COG5518	Phage portal protein
BIS30_RS17050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BIS30_RS17055	COG4653	Phage capsid family
BIS30_RS17105	COG5412	phage tail tape measure protein
BIS30_RS17105	COG5412	phage tail tape measure protein
BIS30_RS17105	COG3953	SLT domain
BIS30_RS17105	COG5412	phage tail tape measure protein
BIS30_RS17105	COG3953	SLT domain
BIS30_RS17105	COG3953	SLT domain
BIS30_RS17110	COG1652	LysM domain
BIS30_RS17115	COG4193	domain, Protein
BIS30_RS17125	COG3628	GPW Gp25 family protein
BIS30_RS17130	COG3299	homolog of phage Mu protein gp47
BIS30_RS17135	COG3778	Protein conserved in bacteria
BIS30_RS17175	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS17175	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS17190	COG0306	phosphate transporter
BIS30_RS17195	COG1392	Phosphate transport regulator
BIS30_RS17200	COG0531	amino acid
BIS30_RS17205	COG0346	lactoylglutathione lyase activity
BIS30_RS17215	COG0463	Glycosyl transferase, family 2
BIS30_RS17225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_RS17230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_RS17235	COG2362	D-Aminopeptidase
BIS30_RS17240	COG0601	transmembrane transport
BIS30_RS17245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_RS17250	COG0444	Belongs to the ABC transporter superfamily
BIS30_RS17255	COG4166	transmembrane transport
BIS30_RS17260	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIS30_RS17265	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_RS17270	COG0791	NLP P60 protein
BIS30_RS17275	COG4608	Belongs to the ABC transporter superfamily
BIS30_RS17280	COG2706	6-phosphogluconolactonase activity
BIS30_RS17285	COG1834	amidinotransferase
BIS30_RS17290	COG1607	acyl-coa hydrolase
BIS30_RS17295	COG1017	nitric oxide dioxygenase activity
BIS30_RS17295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BIS30_RS17305	COG2323	membrane
BIS30_RS17310	COG2318	DinB family
BIS30_RS17315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS17320	COG2076	Multidrug Resistance protein
BIS30_RS17325	COG2076	Multidrug Resistance protein
BIS30_RS17330	COG0788	formyltetrahydrofolate deformylase activity
BIS30_RS17335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIS30_RS17340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIS30_RS17345	COG1764	response to oxidative stress
BIS30_RS17350	COG1846	Transcriptional regulator
BIS30_RS17355	COG1764	response to oxidative stress
BIS30_RS17360	COG0463	Glycosyl transferase, family 2
BIS30_RS17360	COG0457	Tetratricopeptide repeat
BIS30_RS17365	COG0590	tRNA wobble adenosine to inosine editing
BIS30_RS17375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_RS17380	COG1404	Belongs to the peptidase S8 family
BIS30_RS17385	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_RS17390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIS30_RS17395	COG1122	ATPase activity
BIS30_RS17400	COG4721	ABC-type cobalt transport system, permease component
BIS30_RS17410	COG0745	RESPONSE REGULATOR receiver
BIS30_RS17415	COG3850	Histidine kinase
BIS30_RS17415	COG5002	protein histidine kinase activity
BIS30_RS17420	COG3212	peptidase
BIS30_RS17425	COG3212	peptidase
BIS30_RS17440	COG2239	Acts as a magnesium transporter
BIS30_RS17445	COG0789	Transcriptional regulator
BIS30_RS17460	COG1846	Transcriptional regulator
BIS30_RS17465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_RS17470	COG0726	polysaccharide deacetylase
BIS30_RS17475	COG1408	metallophosphoesterase
BIS30_RS17485	COG0463	Glycosyl transferase, family 2
BIS30_RS17490	COG3285	dna ligase
BIS30_RS17490	COG1793	dna ligase
BIS30_RS17495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BIS30_RS17500	COG3300	MHYT domain
BIS30_RS17500	COG5001	Diguanylate cyclase
BIS30_RS17505	COG0586	Pfam SNARE associated Golgi protein
BIS30_RS17510	COG0861	Integral membrane protein TerC family
BIS30_RS17515	COG1191	sigma factor activity
BIS30_RS17535	COG0501	Belongs to the peptidase M48B family
BIS30_RS17540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIS30_RS17555	COG3594	Acyltransferase
BIS30_RS17560	COG5002	protein histidine kinase activity
BIS30_RS17565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIS30_RS17575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BIS30_RS17580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BIS30_RS17585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIS30_RS17590	COG0436	Aminotransferase
BIS30_RS17595	COG1850	ribulose-bisphosphate carboxylase activity
BIS30_RS17600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BIS30_RS17605	COG0235	Class ii aldolase
BIS30_RS17610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BIS30_RS17615	COG3339	Conserved Protein
BIS30_RS17630	COG3852	Histidine kinase
BIS30_RS17635	COG1846	Transcriptional regulator
BIS30_RS17640	COG1360	Flagellar Motor Protein
BIS30_RS17645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIS30_RS17650	COG0542	response to heat
BIS30_RS17655	COG3949	Membrane
BIS30_RS17660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BIS30_RS17665	COG0720	synthase
BIS30_RS17670	COG0602	queuosine metabolic process
BIS30_RS17675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIS30_RS17690	COG4873	Protein conserved in bacteria
BIS30_RS17705	COG3773	Cell wall hydrolase
BIS30_RS17710	COG2244	polysaccharide biosynthetic process
BIS30_RS17715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS17720	COG2217	Heavy metal translocating P-type atpase
BIS30_RS17730	COG0006	proline dipeptidase activity
BIS30_RS17740	COG1609	Transcriptional regulator
BIS30_RS17745	COG3711	transcriptional antiterminator
BIS30_RS17750	COG1263	PTS System
BIS30_RS17750	COG2190	(PTS) system
BIS30_RS17750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_RS17755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS17760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIS30_RS17770	COG1533	DNA photolyase activity
BIS30_RS17775	COG0456	acetyltransferase
BIS30_RS17780	COG0840	transmembrane signaling receptor activity
BIS30_RS17785	COG2084	Dehydrogenase
BIS30_RS17790	COG2340	Cysteine-rich secretory protein family
BIS30_RS17795	COG0768	penicillin binding
BIS30_RS17800	COG4191	Histidine kinase
BIS30_RS17805	COG0436	Aminotransferase
BIS30_RS17815	COG0784	Response regulator, receiver
BIS30_RS17815	COG0835	chemotaxis
BIS30_RS17825	COG2814	Major facilitator Superfamily
BIS30_RS17830	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_RS17835	COG1408	metallophosphoesterase
BIS30_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS17845	COG2200	EAL domain
BIS30_RS17850	COG4703	Protein of unknown function (DUF1797)
BIS30_RS17855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BIS30_RS17865	COG0517	IMP dehydrogenase activity
BIS30_RS17870	COG0583	DNA-binding transcription factor activity
BIS30_RS17875	COG0716	FMN binding
BIS30_RS17885	COG0716	FMN binding
BIS30_RS17890	COG2171	N-acyltransferase activity
BIS30_RS17895	COG1473	amidohydrolase
BIS30_RS17905	COG0668	transmembrane transport
BIS30_RS17910	COG0450	alkyl hydroperoxide reductase
BIS30_RS17915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS17930	COG0746	molybdenum cofactor guanylyltransferase activity
BIS30_RS17935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIS30_RS17940	COG0303	'Molybdopterin
BIS30_RS17945	COG1763	Mo-molybdopterin cofactor biosynthetic process
BIS30_RS17950	COG0314	molybdopterin synthase activity
BIS30_RS17955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BIS30_RS17960	COG1132	(ABC) transporter
BIS30_RS17965	COG1132	(ABC) transporter
BIS30_RS17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIS30_RS17980	COG1136	(ABC) transporter
BIS30_RS17985	COG0577	efflux transmembrane transporter activity
BIS30_RS17990	COG1349	DNA-binding transcription factor activity
BIS30_RS17995	COG1105	Belongs to the carbohydrate kinase PfkB family
BIS30_RS18000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_RS18000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_RS18000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_RS18015	COG0681	Belongs to the peptidase S26 family
BIS30_RS18025	COG0488	(ABC) transporter
BIS30_RS18030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIS30_RS18035	COG2309	aminopeptidase activity
BIS30_RS18045	COG1077	Cell shape determining protein MreB Mrl
BIS30_RS18050	COG2002	toxin-antitoxin pair type II binding
BIS30_RS18055	COG3852	Histidine kinase
BIS30_RS18060	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BIS30_RS18060	COG2105	PFAM AIG2 family protein
BIS30_RS18065	COG0569	domain protein
BIS30_RS18070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIS30_RS18075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIS30_RS18080	COG5503	Protein of unknown function (DUF1447)
BIS30_RS18085	COG0561	phosphatase activity
BIS30_RS18090	COG0242	peptide deformylase activity
BIS30_RS18100	COG0497	DNA recombination
BIS30_RS18105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_RS18110	COG0022	dehydrogenase e1 component
BIS30_RS18115	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_RS18120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_RS18125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS18140	COG1982	Orn Lys Arg decarboxylase major
BIS30_RS18145	COG4476	Belongs to the UPF0223 family
BIS30_RS18150	COG4493	Belongs to the UPF0637 family
BIS30_RS18160	COG0483	inositol monophosphate 1-phosphatase activity
BIS30_RS18170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BIS30_RS18190	COG1595	DNA-templated transcription, initiation
BIS30_RS18210	COG1217	gtp-binding protein TYPA
BIS30_RS18220	COG4896	Protein conserved in bacteria
BIS30_RS18230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BIS30_RS18235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIS30_RS18240	COG2066	Belongs to the glutaminase family
BIS30_RS18245	COG4838	Belongs to the UPF0358 family
BIS30_RS18250	COG0772	Belongs to the SEDS family
BIS30_RS18255	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BIS30_RS18260	COG1612	heme a metabolic process
BIS30_RS18265	COG0109	protoheme IX farnesyltransferase activity
BIS30_RS18270	COG2010	Cytochrome c
BIS30_RS18270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BIS30_RS18275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIS30_RS18280	COG1845	cytochrome c oxidase, subunit III
BIS30_RS18285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIS30_RS18290	COG3336	cytochrome c oxidase
BIS30_RS18300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BIS30_RS18305	COG2340	Cysteine-rich secretory protein family
BIS30_RS18320	COG3679	Belongs to the UPF0342 family
BIS30_RS18325	COG4471	UPF0298 protein
BIS30_RS18330	COG0742	ribosomal rna small subunit methyltransferase
BIS30_RS18335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIS30_RS18340	COG3314	Sporulation integral membrane protein YlbJ
BIS30_RS18345	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIS30_RS18350	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIS30_RS18355	COG1323	Belongs to the UPF0348 family
BIS30_RS18360	COG1399	metal-binding, possibly nucleic acid-binding protein
BIS30_RS18375	COG0454	-acetyltransferase
BIS30_RS18380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIS30_RS18385	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BIS30_RS18390	COG2001	Belongs to the MraZ family
BIS30_RS18395	COG0275	rRNA processing
BIS30_RS18400	COG4839	cell division protein FtsL
BIS30_RS18405	COG0768	penicillin binding
BIS30_RS18415	COG0768	penicillin binding
BIS30_RS18425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIS30_RS18435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIS30_RS18440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIS30_RS18445	COG0772	Belongs to the SEDS family
BIS30_RS18450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_RS18455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIS30_RS18460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIS30_RS18465	COG3879	Bacterial protein of unknown function (DUF881)
BIS30_RS18470	COG3879	Bacterial protein of unknown function (DUF881)
BIS30_RS18475	COG3856	small basic protein
BIS30_RS18480	COG0849	cell division
BIS30_RS18485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIS30_RS18490	COG1404	Belongs to the peptidase S8 family
BIS30_RS18490	COG4412	M6 family metalloprotease domain protein
BIS30_RS18500	COG1191	sigma factor activity
BIS30_RS18505	COG1191	sigma factor activity
BIS30_RS18510	COG1119	ATPase activity
BIS30_RS18515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_RS18520	COG1873	PFAM PRC-barrel domain
BIS30_RS18525	COG1496	oxidoreductase activity
BIS30_RS18530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIS30_RS18535	COG1799	cell septum assembly
BIS30_RS18540	COG0762	integral membrane protein
BIS30_RS18545	COG2302	S4 RNA-binding domain
BIS30_RS18550	COG3599	regulation of cell shape
BIS30_RS18555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIS30_RS18560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIS30_RS18565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIS30_RS18570	COG0564	pseudouridine synthase activity
BIS30_RS18575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIS30_RS18580	COG2233	PERMEase
BIS30_RS18585	COG0540	Belongs to the ATCase OTCase family
BIS30_RS18590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIS30_RS18595	COG0505	Belongs to the CarA family
BIS30_RS18600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIS30_RS18605	COG0543	2 iron, 2 sulfur cluster binding
BIS30_RS18610	COG0167	dihydroorotate dehydrogenase activity
BIS30_RS18615	COG0284	orotidine-5'-phosphate decarboxylase activity
BIS30_RS18620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIS30_RS18630	COG0175	sulfate reduction
BIS30_RS18635	COG0306	phosphate transporter
BIS30_RS18640	COG2046	Belongs to the sulfate adenylyltransferase family
BIS30_RS18645	COG0529	Catalyzes the synthesis of activated sulfate
BIS30_RS18650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BIS30_RS18655	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BIS30_RS18660	COG1648	precorrin-2 dehydrogenase activity
BIS30_RS18665	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BIS30_RS18670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIS30_RS18675	COG1561	YicC-like family, N-terminal region
BIS30_RS18685	COG0194	GDP metabolic process
BIS30_RS18690	COG1758	RNA polymerase activity
BIS30_RS18695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIS30_RS18700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIS30_RS18705	COG0242	peptide deformylase activity
BIS30_RS18710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIS30_RS18715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIS30_RS18715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIS30_RS18720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BIS30_RS18725	COG0631	protein serine/threonine phosphatase activity
BIS30_RS18730	COG0515	serine threonine protein kinase
BIS30_RS18730	COG2815	serine threonine protein kinase
BIS30_RS18735	COG1162	GTPase activity
BIS30_RS18740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIS30_RS18745	COG1564	THIamine pyrophosphokinase
BIS30_RS18755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIS30_RS18760	COG1302	Protein conserved in bacteria
BIS30_RS18765	COG1461	Dihydroxyacetone kinase
BIS30_RS18770	COG1760	l-serine dehydratase
BIS30_RS18775	COG1760	l-serine dehydratase
BIS30_RS18780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIS30_RS18785	COG2050	protein possibly involved in aromatic compounds catabolism
BIS30_RS18785	COG1349	DNA-binding transcription factor activity
BIS30_RS18790	COG0416	fatty acid biosynthetic process
BIS30_RS18795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS18810	COG0571	ribonuclease III activity
BIS30_RS18815	COG1196	nuclear chromosome segregation
BIS30_RS18820	COG0552	protein localization to endoplasmic reticulum
BIS30_RS18840	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIS30_RS18845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIS30_RS18850	COG0228	four-way junction DNA binding
BIS30_RS18855	COG1837	Belongs to the UPF0109 family
BIS30_RS18865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIS30_RS18870	COG0336	Belongs to the RNA methyltransferase TrmD family
BIS30_RS18875	COG0335	large ribosomal subunit rRNA binding
BIS30_RS18885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIS30_RS18895	COG2257	FlhB HrpN YscU SpaS Family
BIS30_RS18900	COG0045	succinate-CoA ligase (ADP-forming) activity
BIS30_RS18905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BIS30_RS18910	COG0758	DNA mediated transformation
BIS30_RS18915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIS30_RS18920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BIS30_RS18925	COG4974	Belongs to the 'phage' integrase family
BIS30_RS18930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIS30_RS18940	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIS30_RS18945	COG1815	bacterial-type flagellum-dependent cell motility
BIS30_RS18950	COG1558	bacterial-type flagellum-dependent cell motility
BIS30_RS18955	COG1677	Flagellar hook-basal body complex protein FliE
BIS30_RS18960	COG1766	The M ring may be actively involved in energy transduction
BIS30_RS18965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_RS18970	COG1317	bacterial-type flagellum organization
BIS30_RS18975	COG1157	protein secretion by the type III secretion system
BIS30_RS18980	COG2882	bacterial-type flagellum organization
BIS30_RS18985	COG3334	PFAM MgtE intracellular
BIS30_RS18990	COG3144	bacterial-type flagellum assembly
BIS30_RS18995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BIS30_RS19000	COG4786	Flagellar basal body rod
BIS30_RS19005	COG1582	Flagellar protein (FlbD)
BIS30_RS19010	COG1580	Controls the rotational direction of flagella during chemotaxis
BIS30_RS19015	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_RS19020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_RS19020	COG1776	CheC inhibitor of MCP methylation
BIS30_RS19025	COG2201	protein-glutamate methylesterase activity
BIS30_RS19030	COG3190	flagellar
BIS30_RS19035	COG1338	Plays a role in the flagellum-specific transport system
BIS30_RS19045	COG1684	flagellar biosynthetic protein fliR
BIS30_RS19050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIS30_RS19055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIS30_RS19060	COG1419	protein localization to endoplasmic reticulum
BIS30_RS19065	COG0455	bacterial-type flagellum organization
BIS30_RS19070	COG2201	protein-glutamate methylesterase activity
BIS30_RS19075	COG0643	Histidine kinase
BIS30_RS19075	COG2198	Histidine kinase
BIS30_RS19080	COG0835	chemotaxis
BIS30_RS19085	COG1776	CheC inhibitor of MCP methylation
BIS30_RS19090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BIS30_RS19095	COG1191	sigma factor activity
BIS30_RS19110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIS30_RS19115	COG0528	UMP kinase activity
BIS30_RS19120	COG0233	cytoplasmic translational termination
BIS30_RS19125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIS30_RS19130	COG4589	Belongs to the CDS family
BIS30_RS19135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BIS30_RS19140	COG0750	zinc metalloprotease
BIS30_RS19145	COG0442	prolyl-tRNA aminoacylation
BIS30_RS19150	COG2176	DNA-directed DNA polymerase activity
BIS30_RS19155	COG0779	Required for maturation of 30S ribosomal subunits
BIS30_RS19160	COG0195	Participates in both transcription termination and antitermination
BIS30_RS19165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BIS30_RS19170	COG1358	cellular component organization or biogenesis
BIS30_RS19175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIS30_RS19180	COG1550	Protein conserved in bacteria
BIS30_RS19185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIS30_RS19190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIS30_RS19200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIS30_RS19205	COG1185	polyribonucleotide nucleotidyltransferase activity
BIS30_RS19210	COG0726	polysaccharide deacetylase
BIS30_RS19215	COG0612	Peptidase, M16
BIS30_RS19220	COG1873	PFAM PRC-barrel domain
BIS30_RS19225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIS30_RS19230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIS30_RS19235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIS30_RS19240	COG0527	aspartate kinase activity
BIS30_RS19245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIS30_RS19250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIS30_RS19255	COG0740	serine-type endopeptidase activity
BIS30_RS19265	COG1674	ftsk spoiiie
BIS30_RS19265	COG4980	gas vesicle protein
BIS30_RS19270	COG2188	Transcriptional regulator
BIS30_RS19275	COG2814	Major facilitator Superfamily
BIS30_RS19280	COG0612	Peptidase, M16
BIS30_RS19285	COG0612	Peptidase, M16
BIS30_RS19290	COG0300	oxidoreductase activity
BIS30_RS19305	COG1426	Protein conserved in bacteria
BIS30_RS19310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIS30_RS19315	COG1058	Belongs to the CinA family
BIS30_RS19315	COG1546	Belongs to the CinA family
BIS30_RS19320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BIS30_RS19325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_RS19330	COG1418	mRNA catabolic process
BIS30_RS19335	COG1692	metallophosphoesterase
BIS30_RS19340	COG2359	stage V sporulation protein S
BIS30_RS19345	COG1063	alcohol dehydrogenase
BIS30_RS19350	COG0156	8-amino-7-oxononanoate synthase activity
BIS30_RS19355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIS30_RS19360	COG4550	Control of competence regulator ComK, YlbF/YmcA
BIS30_RS19370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIS30_RS19375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIS30_RS19400	COG3226	Transcriptional regulator
BIS30_RS19405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS19415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_RS19420	COG3321	synthase
BIS30_RS19425	COG2070	2-Nitropropane dioxygenase
BIS30_RS19425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_RS19430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_RS19435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIS30_RS19440	COG3425	synthase
BIS30_RS19445	COG1024	Enoyl-CoA hydratase
BIS30_RS19450	COG1024	Enoyl-CoA hydratase
BIS30_RS19455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS19455	COG0300	oxidoreductase activity
BIS30_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS19455	COG3321	synthase
BIS30_RS19455	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS19465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_RS19465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_RS19465	COG3321	synthase
BIS30_RS19465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_RS19475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_RS19475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BIS30_RS19475	COG3321	synthase
BIS30_RS19475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BIS30_RS19480	COG2124	cytochrome p450
BIS30_RS19490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_RS19495	COG1404	Belongs to the peptidase S8 family
BIS30_RS19505	COG4195	phage-related replication protein
BIS30_RS19510	COG1764	response to oxidative stress
BIS30_RS19545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIS30_RS19550	COG1923	regulation of RNA biosynthetic process
BIS30_RS19565	COG1780	Probably involved in ribonucleotide reductase function
BIS30_RS19570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIS30_RS19575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIS30_RS19580	COG4112	unkown
BIS30_RS19585	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS19595	COG0464	growth
BIS30_RS19605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIS30_RS19610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BIS30_RS19615	COG0789	Transcriptional regulator
BIS30_RS19620	COG0174	glutamine synthetase
BIS30_RS19635	COG2211	Major facilitator Superfamily
BIS30_RS19640	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_RS19655	COG1070	Carbohydrate kinase
BIS30_RS19670	COG2814	Major facilitator Superfamily
BIS30_RS19675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIS30_RS19685	COG0756	dUTP diphosphatase activity
BIS30_RS19715	COG3832	glyoxalase III activity
BIS30_RS19760	COG4195	phage-related replication protein
BIS30_RS19770	COG0346	lactoylglutathione lyase activity
BIS30_RS19785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIS30_RS19790	COG1388	LysM domain
BIS30_RS19795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIS30_RS19800	COG4224	UPF0291 protein
BIS30_RS19805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIS30_RS19815	COG3763	UPF0154 protein
BIS30_RS19825	COG0785	Cytochrome C biogenesis protein
BIS30_RS19830	COG2201	protein-glutamate methylesterase activity
BIS30_RS19835	COG4846	Membrane protein involved in cytochrome C biogenesis
BIS30_RS19845	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_RS19860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIS30_RS19865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_RS19885	COG0824	Thioesterase
BIS30_RS19895	COG4841	protein insertion into membrane
BIS30_RS19900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIS30_RS19905	COG1832	CoA-binding protein
BIS30_RS19910	COG0187	DNA topoisomerase II activity
BIS30_RS19935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BIS30_RS19945	COG2246	polysaccharide biosynthetic process
BIS30_RS19950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_RS19980	COG2404	hydrolase activity, acting on ester bonds
BIS30_RS19985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIS30_RS19990	COG1024	Enoyl-CoA hydratase
BIS30_RS19995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIS30_RS20000	COG0511	ligase activity, forming carbon-carbon bonds
BIS30_RS20005	COG0439	Biotin carboxylase
BIS30_RS20010	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_RS20015	COG1960	acyl-CoA dehydrogenase activity
BIS30_RS20030	COG1649	PFAM Uncharacterised BCR, COG1649
BIS30_RS20060	COG2027	D-alanyl-D-alanine carboxypeptidase
BIS30_RS20065	COG2017	converts alpha-aldose to the beta-anomer
BIS30_RS20070	COG0534	Mate efflux family protein
BIS30_RS20095	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_RS20095	COG1388	LysM domain
BIS30_RS20095	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_RS20130	COG3942	CHAP domain
BIS30_RS20130	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIS30_RS20245	COG0582	viral genome integration into host DNA
BIS30_RS20345	COG0582	viral genome integration into host DNA
BIS30_RS20350	COG0166	Belongs to the GPI family
BIS30_RS20355	COG0405	Gamma-glutamyltransferase
BIS30_RS20370	COG0493	'glutamate synthase
BIS30_RS20375	COG0067	glutamate synthase
BIS30_RS20375	COG0069	glutamate synthase activity
BIS30_RS20375	COG0070	glutamate synthase
BIS30_RS20380	COG0583	DNA-binding transcription factor activity
BIS30_RS20385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIS30_RS20405	COG0300	oxidoreductase activity
BIS30_RS20410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIS30_RS20420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS20445	COG2814	Major facilitator Superfamily
BIS30_RS20450	COG1070	Carbohydrate kinase
BIS30_RS20460	COG0243	molybdopterin cofactor binding
BIS30_RS20490	COG0840	transmembrane signaling receptor activity
BIS30_RS20490	COG5278	phosphoserine phosphatase activity
BIS30_RS20495	COG2368	4-hydroxyphenylacetate
BIS30_RS20500	COG4305	rare lipoprotein A
BIS30_RS20505	COG3619	membrane
BIS30_RS20530	COG2135	peptidase activity
BIS30_RS20570	COG2720	vancomycin resistance protein
BIS30_RS20580	COG3655	Transcriptional regulator
BIS30_RS20585	COG3739	integral membrane protein
BIS30_RS20590	COG0583	DNA-binding transcription factor activity
BIS30_RS20620	COG0693	protein deglycase activity
BIS30_RS20625	COG2367	Beta-lactamase
BIS30_RS20635	COG3397	chitin binding
BIS30_RS20640	COG2318	DinB family
BIS30_RS20645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_RS20665	COG1215	transferase activity, transferring glycosyl groups
BIS30_RS20700	COG0196	riboflavin kinase activity
BIS30_RS20780	COG0205	6-phosphofructokinase activity
BIS30_RS20795	COG1115	amino acid carrier protein
BIS30_RS20800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BIS30_RS20825	COG3493	citrate carrier protein
BIS30_RS20835	COG1971	Probably functions as a manganese efflux pump
BIS30_RS20880	COG2095	MarC family integral membrane protein
BIS30_RS20895	COG2089	acid synthase
BIS30_RS20960	COG1316	TRANSCRIPTIONal