locus-tag	class	description
CG450_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG450_RS00015	COG0594	ribonuclease P activity
CG450_RS00020	COG0706	membrane insertase activity
CG450_RS00025	COG1847	R3H domain protein
CG450_RS00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG450_RS00035	COG0445	tRNA wobble uridine modification
CG450_RS00040	COG0357	Ribosomal RNA small subunit methyltransferase G
CG450_RS00045	COG1475	DNA binding
CG450_RS00055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CG450_RS00060	COG1192	Involved in chromosome partitioning
CG450_RS00065	COG1475	DNA binding
CG450_RS00075	COG3949	Membrane
CG450_RS00080	COG4481	Protein conserved in bacteria
CG450_RS00090	COG0012	GTP binding
CG450_RS00095	COG0360	Binds together with S18 to 16S ribosomal RNA
CG450_RS00100	COG0629	single-stranded DNA binding
CG450_RS00105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG450_RS00110	COG2271	Major facilitator Superfamily
CG450_RS00115	COG0659	secondary active sulfate transmembrane transporter activity
CG450_RS00120	COG0589	response to stress
CG450_RS00135	COG4241	membrane
CG450_RS00140	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG450_RS00145	COG0359	binds to the 23S rRNA
CG450_RS00150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS00150	COG1263	PTS System
CG450_RS00155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG450_RS00160	COG2188	Transcriptional regulator
CG450_RS00165	COG0363	glucosamine-6-phosphate deaminase activity
CG450_RS00170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CG450_RS00175	COG2807	transmembrane transport
CG450_RS00180	COG3093	addiction module antidote protein HigA
CG450_RS00195	COG0305	Participates in initiation and elongation during chromosome replication
CG450_RS00205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG450_RS00210	COG1051	belongs to the nudix hydrolase family
CG450_RS00235	COG0745	RESPONSE REGULATOR receiver
CG450_RS00240	COG5002	protein histidine kinase activity
CG450_RS00245	COG4863	YycH protein
CG450_RS00250	COG4853	Protein conserved in bacteria
CG450_RS00255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG450_RS00260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG450_RS00275	COG0456	acetyltransferase
CG450_RS00290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG450_RS00315	COG2197	response regulator
CG450_RS00320	COG4585	Histidine kinase
CG450_RS00325	COG0842	Transport permease protein
CG450_RS00330	COG1131	(ABC) transporter
CG450_RS00355	COG3634	alkyl hydroperoxide reductase activity
CG450_RS00360	COG0450	alkyl hydroperoxide reductase
CG450_RS00365	COG1454	alcohol dehydrogenase
CG450_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS00390	COG1940	carbohydrate kinase activity
CG450_RS00395	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CG450_RS00400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG450_RS00410	COG1609	Transcriptional regulator
CG450_RS00415	COG2182	Extracellular solute-binding protein
CG450_RS00420	COG1175	transmembrane transport
CG450_RS00425	COG3833	ABC-type maltose transport systems, permease component
CG450_RS00430	COG1874	Beta-galactosidase
CG450_RS00435	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CG450_RS00440	COG0686	Belongs to the AlaDH PNT family
CG450_RS00445	COG1115	amino acid carrier protein
CG450_RS00450	COG5278	phosphoserine phosphatase activity
CG450_RS00450	COG0840	transmembrane signaling receptor activity
CG450_RS00460	COG0745	RESPONSE REGULATOR receiver
CG450_RS00465	COG2205	protein histidine kinase activity
CG450_RS00470	COG1136	(ABC) transporter
CG450_RS00475	COG0577	efflux transmembrane transporter activity
CG450_RS00480	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CG450_RS00510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS00530	COG0561	phosphatase activity
CG450_RS00535	COG0488	(ABC) transporter
CG450_RS00540	COG0326	Molecular chaperone. Has ATPase activity
CG450_RS00545	COG2271	Major facilitator Superfamily
CG450_RS00550	COG0584	glycerophosphoryl diester phosphodiesterase
CG450_RS00555	COG0667	Aldo Keto reductase
CG450_RS00560	COG1349	DNA-binding transcription factor activity
CG450_RS00565	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS00570	COG3718	enzyme involved in inositol metabolism
CG450_RS00575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG450_RS00580	COG3962	Belongs to the TPP enzyme family
CG450_RS00585	COG1082	Xylose isomerase domain protein TIM barrel
CG450_RS00590	COG2814	Major facilitator Superfamily
CG450_RS00595	COG0673	inositol 2-dehydrogenase activity
CG450_RS00600	COG1082	Xylose isomerase domain protein TIM barrel
CG450_RS00605	COG1082	Xylose isomerase domain protein TIM barrel
CG450_RS00610	COG0191	fructose-bisphosphate aldolase activity
CG450_RS00620	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG450_RS00635	COG3977	Valine--pyruvate aminotransferase
CG450_RS00645	COG1215	transferase activity, transferring glycosyl groups
CG450_RS00650	COG5298	Protein conserved in bacteria
CG450_RS00655	COG3706	GGDEF domain
CG450_RS00660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG450_RS00670	COG2390	Transcriptional regulator
CG450_RS00675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG450_RS00680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG450_RS00685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CG450_RS00715	COG0513	Belongs to the DEAD box helicase family
CG450_RS00720	COG3507	Belongs to the glycosyl hydrolase 43 family
CG450_RS00735	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CG450_RS00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS00745	COG2190	(PTS) system
CG450_RS00745	COG1263	PTS System
CG450_RS00750	COG2723	6-phospho-beta-galactosidase activity
CG450_RS00755	COG0745	RESPONSE REGULATOR receiver
CG450_RS00760	COG2205	protein histidine kinase activity
CG450_RS00765	COG1136	(ABC) transporter
CG450_RS00770	COG0577	efflux transmembrane transporter activity
CG450_RS00775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CG450_RS00785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG450_RS00790	COG2224	Isocitrate lyase
CG450_RS00795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG450_RS00800	COG4721	ABC-type cobalt transport system, permease component
CG450_RS00805	COG1122	ATPase activity
CG450_RS00810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG450_RS00815	COG3711	transcriptional antiterminator
CG450_RS00820	COG2190	(PTS) system
CG450_RS00820	COG1263	PTS System
CG450_RS00820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS00825	COG2723	6-phospho-beta-galactosidase activity
CG450_RS00835	COG0753	catalase activity
CG450_RS00835	COG0693	protein deglycase activity
CG450_RS00840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG450_RS00870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG450_RS00875	COG0463	Glycosyl transferase, family 2
CG450_RS00880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CG450_RS00885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG450_RS00900	COG1609	Transcriptional regulator
CG450_RS00910	COG1175	transmembrane transport
CG450_RS00915	COG0395	ABC-type sugar transport system, permease component
CG450_RS00920	COG2223	nitrite transmembrane transporter activity
CG450_RS00925	COG1621	beta-fructofuranosidase activity
CG450_RS00935	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG450_RS00940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG450_RS00965	COG1595	DNA-templated transcription, initiation
CG450_RS00975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS00980	COG2723	6-phospho-beta-galactosidase activity
CG450_RS00990	COG0549	Belongs to the carbamate kinase family
CG450_RS01000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CG450_RS01005	COG2235	arginine
CG450_RS01020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS01030	COG1368	sulfuric ester hydrolase activity
CG450_RS01045	COG0584	glycerophosphoryl diester phosphodiesterase
CG450_RS01050	COG3493	citrate carrier protein
CG450_RS01055	COG1215	transferase activity, transferring glycosyl groups
CG450_RS01060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG450_RS01065	COG0726	polysaccharide deacetylase
CG450_RS01075	COG5294	Protein conserved in bacteria
CG450_RS01080	COG0577	efflux transmembrane transporter activity
CG450_RS01085	COG1136	(ABC) transporter
CG450_RS01095	COG2205	protein histidine kinase activity
CG450_RS01100	COG0745	RESPONSE REGULATOR receiver
CG450_RS01105	COG2706	6-phosphogluconolactonase activity
CG450_RS01110	COG1396	sequence-specific DNA binding
CG450_RS01115	COG0252	asparaginase activity
CG450_RS01120	COG1027	Aspartate ammonia-lyase
CG450_RS01125	COG1757	Na H antiporter
CG450_RS01130	COG0281	malic enzyme
CG450_RS01140	COG2116	formate transmembrane transporter activity
CG450_RS01150	COG1271	oxidase subunit
CG450_RS01155	COG1294	oxidase, subunit
CG450_RS01160	COG4988	ABC transporter
CG450_RS01165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CG450_RS01170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CG450_RS01225	COG1131	(ABC) transporter
CG450_RS01240	COG1131	(ABC) transporter
CG450_RS01245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG450_RS01250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CG450_RS01255	COG0735	belongs to the Fur family
CG450_RS01260	COG0753	catalase activity
CG450_RS01265	COG0753	catalase activity
CG450_RS01270	COG2814	Major facilitator Superfamily
CG450_RS01275	COG1595	DNA-templated transcription, initiation
CG450_RS01295	COG1131	(ABC) transporter
CG450_RS01300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG450_RS01305	COG2814	Major facilitator Superfamily
CG450_RS01320	COG2755	lipolytic protein G-D-S-L family
CG450_RS01325	COG1132	(ABC) transporter
CG450_RS01340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG450_RS01345	COG2079	MmgE PrpD family protein
CG450_RS01350	COG0372	Belongs to the citrate synthase family
CG450_RS01360	COG2094	Belongs to the DNA glycosylase MPG family
CG450_RS01365	COG3711	transcriptional antiterminator
CG450_RS01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS01370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS01375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS01380	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG450_RS01385	COG1486	melibiose metabolic process
CG450_RS01390	COG2814	Major facilitator Superfamily
CG450_RS01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG450_RS01400	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG450_RS01405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG450_RS01410	COG1696	Membrane protein involved in D-alanine export
CG450_RS01415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG450_RS01430	COG2357	RelA SpoT domain protein
CG450_RS01440	COG0477	Major facilitator Superfamily
CG450_RS01445	COG2234	aminopeptidase activity
CG450_RS01455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG450_RS01460	COG0800	Aldolase
CG450_RS01465	COG4948	Mandelate Racemase Muconate Lactonizing
CG450_RS01470	COG2271	Major facilitator Superfamily
CG450_RS01475	COG5522	Integral membrane protein (intg_mem_TP0381)
CG450_RS01480	COG2409	Drug exporters of the RND superfamily
CG450_RS01485	COG2197	response regulator
CG450_RS01490	COG4585	Histidine kinase
CG450_RS01505	COG1442	glycosyl transferase family 8
CG450_RS01510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG450_RS01515	COG0346	lactoylglutathione lyase activity
CG450_RS01520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG450_RS01525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS01535	COG1346	cytolysis
CG450_RS01540	COG1380	Effector of murein hydrolase LrgA
CG450_RS01555	COG0583	DNA-binding transcription factor activity
CG450_RS01560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG450_RS01565	COG0352	thiamine-phosphate diphosphorylase activity
CG450_RS01575	COG2115	Belongs to the xylose isomerase family
CG450_RS01580	COG1070	Carbohydrate kinase
CG450_RS01585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS01590	COG3162	membrane
CG450_RS01610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG450_RS01615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG450_RS01620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG450_RS01630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CG450_RS01665	COG0456	acetyltransferase
CG450_RS01685	COG3314	Sporulation integral membrane protein YlbJ
CG450_RS01690	COG0772	Belongs to the SEDS family
CG450_RS01695	COG0772	Belongs to the SEDS family
CG450_RS01700	COG1473	amidohydrolase
CG450_RS01705	COG0778	Nitroreductase
CG450_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG450_RS01720	COG1404	Belongs to the peptidase S8 family
CG450_RS01730	COG3711	transcriptional antiterminator
CG450_RS01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS01735	COG1263	PTS System
CG450_RS01740	COG1621	beta-fructofuranosidase activity
CG450_RS01755	COG0351	phosphomethylpyrimidine kinase
CG450_RS01760	COG1216	Glycosyl transferase, family 2
CG450_RS01765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG450_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS01780	COG2233	PERMEase
CG450_RS01785	COG2363	Small membrane protein
CG450_RS01800	COG1131	(ABC) transporter
CG450_RS01820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG450_RS01835	COG3253	May function as heme-dependent peroxidase
CG450_RS01840	COG0280	phosphate acetyltransferase
CG450_RS01850	COG1414	Transcriptional regulator
CG450_RS01875	COG2814	Major facilitator Superfamily
CG450_RS01900	COG4844	belongs to the
CG450_RS01905	COG1078	dGTPase activity
CG450_RS01910	COG3465	dGTPase activity
CG450_RS01920	COG1942	4-Oxalocrotonate Tautomerase
CG450_RS01925	COG1994	Peptidase M50
CG450_RS01935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG450_RS01950	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG450_RS01955	COG0010	Belongs to the arginase family
CG450_RS01960	COG4506	Protein conserved in bacteria
CG450_RS01965	COG0018	arginyl-trna synthetase
CG450_RS01975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG450_RS01980	COG2181	nitrate reductase activity
CG450_RS01980	COG0247	lactate metabolic process
CG450_RS01985	COG0183	Belongs to the thiolase family
CG450_RS01990	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG450_RS01995	COG1960	acyl-CoA dehydrogenase activity
CG450_RS02000	COG1960	acyl-CoA dehydrogenase activity
CG450_RS02005	COG3343	RNA polymerase activity
CG450_RS02010	COG0504	CTP synthase activity
CG450_RS02015	COG4821	SIS domain
CG450_RS02020	COG2204	response regulator
CG450_RS02025	COG0191	fructose-bisphosphate aldolase activity
CG450_RS02030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG450_RS02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CG450_RS02040	COG1494	fructose-1,6-bisphosphatase
CG450_RS02045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG450_RS02050	COG0254	rRNA binding
CG450_RS02055	COG1435	thymidine kinase activity
CG450_RS02060	COG0281	malic enzyme
CG450_RS02065	COG0679	Auxin Efflux Carrier
CG450_RS02070	COG0789	Transcriptional regulator
CG450_RS02075	COG0346	lactoylglutathione lyase activity
CG450_RS02080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG450_RS02085	COG2890	protein-(glutamine-N5) methyltransferase activity
CG450_RS02090	COG1609	Transcriptional regulator
CG450_RS02095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CG450_RS02100	COG0561	phosphatase activity
CG450_RS02105	COG0673	inositol 2-dehydrogenase activity
CG450_RS02110	COG0738	Major facilitator superfamily
CG450_RS02120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CG450_RS02125	COG0009	L-threonylcarbamoyladenylate synthase
CG450_RS02130	COG1971	Probably functions as a manganese efflux pump
CG450_RS02135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG450_RS02140	COG0698	ribose 5-phosphate isomerase
CG450_RS02145	COG4475	Protein of unknown function (DUF436)
CG450_RS02150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG450_RS02155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG450_RS02175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG450_RS02180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG450_RS02185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG450_RS02190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG450_RS02195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG450_RS02200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG450_RS02205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG450_RS02210	COG4836	Membrane
CG450_RS02220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CG450_RS02225	COG2385	sporulation resulting in formation of a cellular spore
CG450_RS02230	COG2304	oxidoreductase activity
CG450_RS02235	COG2304	oxidoreductase activity
CG450_RS02240	COG3383	formate dehydrogenase (NAD+) activity
CG450_RS02245	COG2223	nitrite transmembrane transporter activity
CG450_RS02250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG450_RS02255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG450_RS02260	COG1994	Peptidase M50
CG450_RS02265	COG1959	2 iron, 2 sulfur cluster binding
CG450_RS02270	COG2910	NAD(P)H-binding
CG450_RS02280	COG2207	Transcriptional regulator
CG450_RS02280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS02285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS02290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS02295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS02300	COG2819	hydrolase of the alpha beta superfamily
CG450_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS02310	COG1169	isochorismate synthase
CG450_RS02315	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG450_RS02320	COG1535	isochorismatase
CG450_RS02320	COG3433	isochorismatase activity
CG450_RS02325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG450_RS02330	COG3251	PFAM MbtH domain protein
CG450_RS02335	COG0477	Major facilitator Superfamily
CG450_RS02340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG450_RS02350	COG1247	-acetyltransferase
CG450_RS02355	COG0739	heme binding
CG450_RS02365	COG0740	serine-type endopeptidase activity
CG450_RS02370	COG0347	Belongs to the P(II) protein family
CG450_RS02375	COG0004	ammonium transporteR
CG450_RS02380	COG1253	flavin adenine dinucleotide binding
CG450_RS02385	COG0598	Magnesium transport protein CorA
CG450_RS02390	COG0517	IMP dehydrogenase activity
CG450_RS02395	COG3361	conserved protein (COG2071)
CG450_RS02400	COG3546	catalase activity
CG450_RS02405	COG1227	inorganic diphosphatase activity
CG450_RS02410	COG0671	phosphoesterase, PA-phosphatase related
CG450_RS02415	COG2814	Major facilitator Superfamily
CG450_RS02420	COG1846	Transcriptional regulator
CG450_RS02430	COG1609	Transcriptional regulator
CG450_RS02435	COG1077	Cell shape determining protein MreB Mrl
CG450_RS02440	COG4786	Flagellar basal body rod
CG450_RS02445	COG4786	Flagellar basal body rod
CG450_RS02450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG450_RS02455	COG1970	mechanosensitive ion channel activity
CG450_RS02470	COG0629	single-stranded DNA binding
CG450_RS02490	COG3732	PTS system glucitol sorbitol-specific
CG450_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS02510	COG1349	DNA-binding transcription factor activity
CG450_RS02515	COG0561	phosphatase activity
CG450_RS02520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG450_RS02525	COG4715	Zinc finger, swim domain protein
CG450_RS02535	COG3944	biosynthesis protein
CG450_RS02540	COG4464	protein tyrosine phosphatase activity
CG450_RS02545	COG2059	Chromate
CG450_RS02550	COG2059	Chromate
CG450_RS02555	COG1522	sequence-specific DNA binding
CG450_RS02560	COG0405	Gamma-glutamyltransferase
CG450_RS02565	COG0583	DNA-binding transcription factor activity
CG450_RS02570	COG0028	Belongs to the TPP enzyme family
CG450_RS02575	COG3527	Alpha-acetolactate decarboxylase
CG450_RS02585	COG1879	ABC-type sugar transport system periplasmic component
CG450_RS02590	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG450_RS02595	COG1129	ABC transporter
CG450_RS02600	COG1869	D-ribose catabolic process
CG450_RS02605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG450_RS02610	COG1609	Transcriptional regulator
CG450_RS02615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG450_RS02625	COG2843	Capsule synthesis protein
CG450_RS02635	COG0791	NLP P60 protein
CG450_RS02640	COG0561	phosphatase activity
CG450_RS02645	COG1316	TRANSCRIPTIONal
CG450_RS02650	COG2814	Major facilitator Superfamily
CG450_RS02655	COG1063	alcohol dehydrogenase
CG450_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS02665	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CG450_RS02670	COG1609	Transcriptional regulator
CG450_RS02675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG450_RS02680	COG0800	Aldolase
CG450_RS02700	COG1482	cell wall glycoprotein biosynthetic process
CG450_RS02705	COG4193	domain, Protein
CG450_RS02710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG450_RS02715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG450_RS02720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG450_RS02725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG450_RS02730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG450_RS02730	COG0463	Glycosyl transferase, family 2
CG450_RS02745	COG1682	transport, permease protein
CG450_RS02750	COG1134	teichoic acid transport
CG450_RS02755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG450_RS02760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG450_RS02765	COG1316	TRANSCRIPTIONal
CG450_RS02775	COG2247	cell wall binding repeat
CG450_RS02775	COG2385	sporulation resulting in formation of a cellular spore
CG450_RS02780	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS02780	COG2247	cell wall binding repeat
CG450_RS02790	COG2244	polysaccharide biosynthetic process
CG450_RS02795	COG0297	glycogen (starch) synthase activity
CG450_RS02795	COG0438	transferase activity, transferring glycosyl groups
CG450_RS02800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG450_RS02805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG450_RS02810	COG3307	-O-antigen
CG450_RS02815	COG3206	protein involved in exopolysaccharide biosynthesis
CG450_RS02820	COG1215	transferase activity, transferring glycosyl groups
CG450_RS02825	COG0438	transferase activity, transferring glycosyl groups
CG450_RS02830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG450_RS02840	COG1316	TRANSCRIPTIONal
CG450_RS02845	COG1739	Uncharacterized protein family UPF0029
CG450_RS02850	COG4585	Histidine kinase
CG450_RS02855	COG2197	response regulator
CG450_RS02860	COG1307	EDD domain protein, DegV family
CG450_RS02865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG450_RS02875	COG1040	competence protein
CG450_RS02885	COG2747	anti-sigma28 factor FlgM
CG450_RS02890	COG3418	PFAM FlgN family protein
CG450_RS02895	COG1256	bacterial-type flagellum assembly
CG450_RS02895	COG4786	Flagellar basal body rod
CG450_RS02900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG450_RS02910	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CG450_RS02915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CG450_RS02920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG450_RS02930	COG1334	flagellar protein FlaG
CG450_RS02935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG450_RS02940	COG1516	flagellar protein fliS
CG450_RS02955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CG450_RS02960	COG0653	protein targeting
CG450_RS02970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS02975	COG2010	Cytochrome c
CG450_RS02985	COG2884	Cell division ATP-binding protein ftsE
CG450_RS02990	COG2177	Part of the ABC transporter FtsEX involved in
CG450_RS02995	COG3883	PFAM NLP P60 protein
CG450_RS02995	COG0791	NLP P60 protein
CG450_RS03000	COG0473	3-isopropylmalate dehydrogenase activity
CG450_RS03005	COG3409	Peptidoglycan-binding domain 1 protein
CG450_RS03005	COG0793	Belongs to the peptidase S41A family
CG450_RS03015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG450_RS03025	COG4897	Protein conserved in bacteria
CG450_RS03030	COG0556	nucleotide-excision repair
CG450_RS03035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG450_RS03060	COG3595	metallopeptidase activity
CG450_RS03065	COG1983	PspC domain protein
CG450_RS03070	COG1950	PFAM Membrane protein of
CG450_RS03075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CG450_RS03080	COG2814	Major facilitator Superfamily
CG450_RS03085	COG1846	Transcriptional regulator
CG450_RS03090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG450_RS03095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG450_RS03100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG450_RS03105	COG0546	phosphoglycolate phosphatase activity
CG450_RS03110	COG0110	maltose O-acetyltransferase activity
CG450_RS03115	COG5297	Belongs to the glycosyl hydrolase family 6
CG450_RS03120	COG4990	cell redox homeostasis
CG450_RS03125	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CG450_RS03130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG450_RS03135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CG450_RS03140	COG0131	Imidazoleglycerol-phosphate dehydratase
CG450_RS03145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG450_RS03150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG450_RS03155	COG0107	imidazoleglycerol-phosphate synthase activity
CG450_RS03160	COG0140	phosphoribosyl-ATP diphosphatase activity
CG450_RS03160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG450_RS03165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS03170	COG0457	Tetratricopeptide repeat
CG450_RS03175	COG0492	ferredoxin-NADP+ reductase activity
CG450_RS03185	COG1051	belongs to the nudix hydrolase family
CG450_RS03190	COG1660	Displays ATPase and GTPase activities
CG450_RS03195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG450_RS03200	COG1481	regulation of sporulation
CG450_RS03205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS03210	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG450_RS03215	COG2732	(Barnase) inhibitor
CG450_RS03225	COG0640	Transcriptional regulator
CG450_RS03230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG450_RS03235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG450_RS03240	COG0288	reversible hydration of carbon dioxide
CG450_RS03245	COG0659	secondary active sulfate transmembrane transporter activity
CG450_RS03250	COG1078	dGTPase activity
CG450_RS03255	COG1694	Mazg nucleotide pyrophosphohydrolase
CG450_RS03260	COG1611	Belongs to the LOG family
CG450_RS03265	COG0740	serine-type endopeptidase activity
CG450_RS03280	COG1621	beta-fructofuranosidase activity
CG450_RS03285	COG1621	beta-fructofuranosidase activity
CG450_RS03290	COG1902	pentaerythritol trinitrate reductase activity
CG450_RS03295	COG1733	regulation of RNA biosynthetic process
CG450_RS03305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG450_RS03320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CG450_RS03330	COG2271	Major facilitator Superfamily
CG450_RS03335	COG2249	NAD(P)H dehydrogenase (quinone) activity
CG450_RS03340	COG1396	sequence-specific DNA binding
CG450_RS03345	COG3944	biosynthesis protein
CG450_RS03350	COG0489	protein tyrosine kinase activity
CG450_RS03355	COG1086	Polysaccharide biosynthesis protein
CG450_RS03360	COG0438	transferase activity, transferring glycosyl groups
CG450_RS03365	COG1215	transferase activity, transferring glycosyl groups
CG450_RS03370	COG0438	transferase activity, transferring glycosyl groups
CG450_RS03380	COG1216	Glycosyl transferase, family 2
CG450_RS03385	COG5039	Polysaccharide pyruvyl transferase
CG450_RS03390	COG1216	Glycosyl transferase, family 2
CG450_RS03395	COG2244	polysaccharide biosynthetic process
CG450_RS03400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CG450_RS03405	COG0110	maltose O-acetyltransferase activity
CG450_RS03410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CG450_RS03415	COG5039	Polysaccharide pyruvyl transferase
CG450_RS03425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG450_RS03430	COG1620	l-lactate permease
CG450_RS03435	COG2186	Transcriptional regulator
CG450_RS03440	COG0247	lactate metabolic process
CG450_RS03445	COG1139	Iron-sulfur cluster binding protein
CG450_RS03450	COG1556	Lactate utilization protein
CG450_RS03470	COG1113	amino acid transport
CG450_RS03475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG450_RS03480	COG2390	Transcriptional regulator
CG450_RS03485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG450_RS03490	COG0126	phosphoglycerate kinase activity
CG450_RS03495	COG0149	triose-phosphate isomerase activity
CG450_RS03500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG450_RS03505	COG0148	phosphopyruvate hydratase activity
CG450_RS03510	COG0693	protein deglycase activity
CG450_RS03520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS03530	COG3064	Membrane
CG450_RS03535	COG2095	MarC family integral membrane protein
CG450_RS03540	COG1510	regulation of RNA biosynthetic process
CG450_RS03545	COG0517	IMP dehydrogenase activity
CG450_RS03545	COG1125	glycine betaine transport
CG450_RS03550	COG1174	glycine betaine transport
CG450_RS03555	COG1732	Glycine betaine
CG450_RS03560	COG1174	glycine betaine transport
CG450_RS03565	COG1396	sequence-specific DNA binding
CG450_RS03570	COG1396	sequence-specific DNA binding
CG450_RS03575	COG1476	TRANSCRIPTIONal
CG450_RS03580	COG2002	toxin-antitoxin pair type II binding
CG450_RS03585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG450_RS03590	COG1647	Serine aminopeptidase, S33
CG450_RS03595	COG0557	exoribonuclease II activity
CG450_RS03600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG450_RS03640	COG2140	Oxalate decarboxylase
CG450_RS03650	COG1191	sigma factor activity
CG450_RS03660	COG1054	Belongs to the UPF0176 family
CG450_RS03665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CG450_RS03670	COG0673	inositol 2-dehydrogenase activity
CG450_RS03680	COG1846	Transcriptional regulator
CG450_RS03690	COG2124	cytochrome p450
CG450_RS03700	COG2814	Major facilitator Superfamily
CG450_RS03705	COG2814	Major facilitator Superfamily
CG450_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS03710	COG3347	Dehydrogenase
CG450_RS03720	COG4952	isomerase
CG450_RS03725	COG1070	Carbohydrate kinase
CG450_RS03730	COG1349	DNA-binding transcription factor activity
CG450_RS03735	COG0693	protein deglycase activity
CG450_RS03740	COG1937	Protein conserved in bacteria
CG450_RS03745	COG2608	mercury ion transmembrane transporter activity
CG450_RS03750	COG2217	Heavy metal translocating P-type atpase
CG450_RS03765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS03765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS03765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS03770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG450_RS03770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CG450_RS03785	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG450_RS03790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG450_RS03795	COG1121	(ABC) transporter
CG450_RS03800	COG1472	Belongs to the glycosyl hydrolase 3 family
CG450_RS03805	COG1501	Belongs to the glycosyl hydrolase 31 family
CG450_RS03810	COG0395	ABC-type sugar transport system, permease component
CG450_RS03815	COG1175	transmembrane transport
CG450_RS03825	COG2217	Heavy metal translocating P-type atpase
CG450_RS03830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG450_RS03835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CG450_RS03840	COG0456	acetyltransferase
CG450_RS03845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG450_RS03845	COG0456	acetyltransferase
CG450_RS03850	COG2860	membrane
CG450_RS03855	COG3973	AAA domain
CG450_RS03865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG450_RS03870	COG1940	carbohydrate kinase activity
CG450_RS03875	COG0656	L-ascorbic acid biosynthetic process
CG450_RS03880	COG2814	Major facilitator Superfamily
CG450_RS03885	COG1368	sulfuric ester hydrolase activity
CG450_RS03890	COG1988	membrane-bound metal-dependent
CG450_RS03900	COG0531	amino acid
CG450_RS03905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS03910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS03915	COG1120	ATPase activity
CG450_RS03920	COG0745	RESPONSE REGULATOR receiver
CG450_RS03925	COG2205	protein histidine kinase activity
CG450_RS03930	COG1904	glucuronate isomerase
CG450_RS03935	COG2211	Major facilitator Superfamily
CG450_RS03940	COG1609	Transcriptional regulator
CG450_RS03945	COG0246	Mannitol dehydrogenase
CG450_RS03950	COG2721	sulfolactate sulfo-lyase activity
CG450_RS03960	COG0583	DNA-binding transcription factor activity
CG450_RS03965	COG2258	MOSC domain
CG450_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS03975	COG1802	Transcriptional regulator
CG450_RS03980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS03985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS03990	COG1120	ATPase activity
CG450_RS03995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG450_RS04000	COG1454	alcohol dehydrogenase
CG450_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS04015	COG2096	Adenosyltransferase
CG450_RS04020	COG4677	pectinesterase activity
CG450_RS04025	COG4758	membrane
CG450_RS04030	COG1842	Phage shock protein A
CG450_RS04040	COG4758	membrane
CG450_RS04045	COG4585	Histidine kinase
CG450_RS04050	COG2197	response regulator
CG450_RS04065	COG0814	amino acid
CG450_RS04070	COG0697	spore germination
CG450_RS04080	COG0114	fumarate hydratase activity
CG450_RS04085	COG1309	transcriptional regulator
CG450_RS04095	COG2770	Histidine kinase
CG450_RS04095	COG2205	protein histidine kinase activity
CG450_RS04100	COG0745	RESPONSE REGULATOR receiver
CG450_RS04105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG450_RS04110	COG0783	Belongs to the Dps family
CG450_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS04120	COG1686	Belongs to the peptidase S11 family
CG450_RS04135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS04140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS04145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS04150	COG1120	ATPase activity
CG450_RS04165	COG5577	PFAM Coat F domain
CG450_RS04180	COG1024	Enoyl-CoA hydratase
CG450_RS04180	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG450_RS04185	COG0183	Belongs to the thiolase family
CG450_RS04190	COG1960	acyl-CoA dehydrogenase activity
CG450_RS04195	COG1393	Belongs to the ArsC family
CG450_RS04200	COG0509	glycine decarboxylation via glycine cleavage system
CG450_RS04210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG450_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS04225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CG450_RS04230	COG2011	ABC-type metal ion transport system permease component
CG450_RS04235	COG1464	Belongs to the NlpA lipoprotein family
CG450_RS04240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CG450_RS04250	COG0396	ATPase activity
CG450_RS04255	COG0719	Fe-S assembly protein
CG450_RS04260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG450_RS04265	COG0822	iron-sulfur transferase activity
CG450_RS04270	COG0719	Fe-S assembly protein
CG450_RS04275	COG0457	Tetratricopeptide repeat
CG450_RS04290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG450_RS04300	COG2356	endonuclease I
CG450_RS04305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CG450_RS04310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CG450_RS04315	COG1288	antiporter activity
CG450_RS04320	COG2814	Major facilitator Superfamily
CG450_RS04325	COG2508	Transcriptional regulator
CG450_RS04330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG450_RS04335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG450_RS04345	COG3226	Transcriptional regulator
CG450_RS04355	COG1801	Protein of unknown function DUF72
CG450_RS04360	COG0730	response to heat
CG450_RS04365	COG0737	Belongs to the 5'-nucleotidase family
CG450_RS04370	COG3377	Domain of unknown function (DUF1805)
CG450_RS04380	COG0733	neurotransmitter:sodium symporter activity
CG450_RS04390	COG0739	heme binding
CG450_RS04405	COG4470	Protein conserved in bacteria
CG450_RS04410	COG2445	Protein of unknown function DUF86
CG450_RS04415	COG0647	UMP catabolic process
CG450_RS04420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG450_RS04425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG450_RS04435	COG0460	homoserine dehydrogenase
CG450_RS04440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CG450_RS04445	COG0083	homoserine kinase activity
CG450_RS04450	COG1506	peptidase
CG450_RS04450	COG0823	Involved in the tonB-independent uptake of proteins
CG450_RS04450	COG4946	Tricorn protease homolog
CG450_RS04455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG450_RS04460	COG4837	Protein of unknown function (DUF1462)
CG450_RS04470	COG3479	Phenolic acid decarboxylase
CG450_RS04475	COG0457	Tetratricopeptide repeat
CG450_RS04485	COG5646	InterPro IPR014922
CG450_RS04490	COG1252	NADH dehydrogenase
CG450_RS04495	COG4844	belongs to the
CG450_RS04500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG450_RS04505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG450_RS04510	COG0316	Belongs to the HesB IscA family
CG450_RS04515	COG0456	acetyltransferase
CG450_RS04530	COG0492	ferredoxin-NADP+ reductase activity
CG450_RS04535	COG1252	NADH dehydrogenase
CG450_RS04545	COG3584	3D domain protein
CG450_RS04550	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG450_RS04555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG450_RS04560	COG2056	Na+-H+ antiporter family
CG450_RS04565	COG1268	BioY protein
CG450_RS04570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG450_RS04580	COG0686	Belongs to the AlaDH PNT family
CG450_RS04585	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG450_RS04585	COG2508	Transcriptional regulator
CG450_RS04590	COG1115	amino acid carrier protein
CG450_RS04595	COG4842	Belongs to the WXG100 family
CG450_RS04600	COG5417	Belongs to the EsaB family
CG450_RS04605	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG450_RS04610	COG0433	COG0433 Predicted ATPase
CG450_RS04610	COG1674	ftsk spoiiie
CG450_RS04615	COG1511	domain protein
CG450_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS04630	COG1418	mRNA catabolic process
CG450_RS04640	COG0657	acetylesterase activity
CG450_RS04645	COG1959	2 iron, 2 sulfur cluster binding
CG450_RS04650	COG0628	permease
CG450_RS04665	COG5506	Protein of unknown function (DUF1694)
CG450_RS04670	COG1335	isochorismatase
CG450_RS04675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG450_RS04680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CG450_RS04710	COG4585	Histidine kinase
CG450_RS04715	COG2197	response regulator
CG450_RS04720	COG2050	protein possibly involved in aromatic compounds catabolism
CG450_RS04725	COG1320	monovalent cation:proton antiporter activity
CG450_RS04730	COG2212	antiporter activity
CG450_RS04735	COG1863	multisubunit Na H antiporter MnhE subunit
CG450_RS04740	COG0651	ATP synthesis coupled electron transport
CG450_RS04745	COG1006	Multisubunit Na H antiporter MnhC subunit
CG450_RS04750	COG2111	Na H antiporter
CG450_RS04755	COG2111	Na H antiporter
CG450_RS04755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG450_RS04765	COG3493	citrate carrier protein
CG450_RS04770	COG0688	phosphatidylethanolamine metabolic process
CG450_RS04775	COG0586	Pfam SNARE associated Golgi protein
CG450_RS04780	COG1183	phosphatidylcholine synthase activity
CG450_RS04790	COG4565	transcriptional regulatory protein
CG450_RS04795	COG3290	protein histidine kinase activity
CG450_RS04805	COG3011	Protein conserved in bacteria
CG450_RS04810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG450_RS04815	COG2814	Major facilitator Superfamily
CG450_RS04820	COG5018	Exonuclease
CG450_RS04835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG450_RS04850	COG2267	carboxylic ester hydrolase activity
CG450_RS04855	COG1522	sequence-specific DNA binding
CG450_RS04860	COG0436	Aminotransferase
CG450_RS04865	COG1098	S1 RNA binding domain
CG450_RS04870	COG2155	Conserved Protein
CG450_RS04875	COG1979	alcohol dehydrogenase
CG450_RS04880	COG0166	Belongs to the GPI family
CG450_RS04890	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CG450_RS04895	COG2323	membrane
CG450_RS04905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG450_RS04915	COG2738	Putative neutral zinc metallopeptidase
CG450_RS04920	COG1253	flavin adenine dinucleotide binding
CG450_RS04925	COG5297	Belongs to the glycosyl hydrolase family 6
CG450_RS04940	COG0366	Alpha amylase catalytic
CG450_RS04945	COG0432	Pfam Uncharacterised protein family UPF0047
CG450_RS04960	COG0840	transmembrane signaling receptor activity
CG450_RS04965	COG0840	transmembrane signaling receptor activity
CG450_RS04970	COG0840	transmembrane signaling receptor activity
CG450_RS04975	COG0693	protein deglycase activity
CG450_RS04980	COG0673	inositol 2-dehydrogenase activity
CG450_RS04985	COG0628	permease
CG450_RS04990	COG1968	undecaprenyl-diphosphatase activity
CG450_RS04995	COG1408	metallophosphoesterase
CG450_RS05000	COG0726	polysaccharide deacetylase
CG450_RS05005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG450_RS05015	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CG450_RS05055	COG0582	viral genome integration into host DNA
CG450_RS05075	COG1476	TRANSCRIPTIONal
CG450_RS05115	COG5377	YqaJ viral recombinase family
CG450_RS05120	COG3723	Recombinational DNA repair protein, rece pathway
CG450_RS05135	COG0305	Participates in initiation and elongation during chromosome replication
CG450_RS05150	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CG450_RS05195	COG0457	Tetratricopeptide repeat
CG450_RS05200	COG5444	nuclease activity
CG450_RS05235	COG1783	phage Terminase large subunit
CG450_RS05245	COG2369	cell adhesion
CG450_RS05255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CG450_RS05260	COG4653	Phage capsid family
CG450_RS05320	COG3953	SLT domain
CG450_RS05320	COG5280	Phage tail tape measure protein TP901
CG450_RS05320	COG5280	Phage tail tape measure protein TP901
CG450_RS05320	COG3953	SLT domain
CG450_RS05325	COG1652	LysM domain
CG450_RS05330	COG4193	domain, Protein
CG450_RS05340	COG3628	GPW Gp25 family protein
CG450_RS05345	COG3299	homolog of phage Mu protein gp47
CG450_RS05350	COG3778	Protein conserved in bacteria
CG450_RS05400	COG1793	dna ligase
CG450_RS05420	COG2140	Oxalate decarboxylase
CG450_RS05425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG450_RS05430	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG450_RS05440	COG1510	regulation of RNA biosynthetic process
CG450_RS05445	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS05450	COG1454	alcohol dehydrogenase
CG450_RS05460	COG2318	DinB family
CG450_RS05470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG450_RS05475	COG0569	domain protein
CG450_RS05480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG450_RS05485	COG0457	Tetratricopeptide repeat
CG450_RS05500	COG3764	Sortase (surface protein transpeptidase)
CG450_RS05505	COG3859	Proton-coupled thiamine transporter YuaJ
CG450_RS05510	COG1609	Transcriptional regulator
CG450_RS05635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG450_RS05640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG450_RS05645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG450_RS05650	COG0297	glycogen (starch) synthase activity
CG450_RS05655	COG0058	SHG alpha-glucan phosphorylase activity
CG450_RS05660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG450_RS05665	COG1575	Belongs to the MenA family. Type 1 subfamily
CG450_RS05670	COG1169	isochorismate synthase
CG450_RS05675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG450_RS05680	COG0596	Alpha beta hydrolase
CG450_RS05685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG450_RS05690	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS05695	COG4948	Mandelate Racemase Muconate Lactonizing
CG450_RS05710	COG1294	oxidase, subunit
CG450_RS05715	COG1271	oxidase subunit
CG450_RS05720	COG0254	rRNA binding
CG450_RS05725	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG450_RS05730	COG0523	cobalamin synthesis protein
CG450_RS05735	COG0288	reversible hydration of carbon dioxide
CG450_RS05740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG450_RS05745	COG1854	S-ribosylhomocysteine lyase activity
CG450_RS05760	COG0783	Belongs to the Dps family
CG450_RS05765	COG4824	toxin secretion phage lysis holin
CG450_RS05775	COG0494	nUDIX hydrolase
CG450_RS05780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG450_RS05785	COG1116	anion transmembrane transporter activity
CG450_RS05790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG450_RS05795	COG1506	peptidase
CG450_RS05810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG450_RS05815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG450_RS05820	COG0367	asparagine synthase
CG450_RS05825	COG0438	transferase activity, transferring glycosyl groups
CG450_RS05825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG450_RS05830	COG0671	phosphoesterase, PA-phosphatase related
CG450_RS05835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG450_RS05840	COG2267	carboxylic ester hydrolase activity
CG450_RS05850	COG1301	dicarboxylic acid transport
CG450_RS05855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG450_RS05860	COG1242	4 iron, 4 sulfur cluster binding
CG450_RS05870	COG1725	Transcriptional regulator
CG450_RS05875	COG1131	(ABC) transporter
CG450_RS05885	COG1136	(ABC) transporter
CG450_RS05890	COG0577	efflux transmembrane transporter activity
CG450_RS05895	COG2433	Pfam Transposase IS66
CG450_RS05905	COG2814	Major facilitator Superfamily
CG450_RS05915	COG0495	leucyl-tRNA aminoacylation
CG450_RS05920	COG0346	lactoylglutathione lyase activity
CG450_RS05925	COG0583	DNA-binding transcription factor activity
CG450_RS05935	COG1073	alpha beta
CG450_RS05940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG450_RS05945	COG0395	ABC-type sugar transport system, permease component
CG450_RS05950	COG1653	transport
CG450_RS05955	COG2207	Transcriptional regulator
CG450_RS05960	COG4209	transmembrane transport
CG450_RS05965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CG450_RS05970	COG1653	transport
CG450_RS05975	COG0673	inositol 2-dehydrogenase activity
CG450_RS05980	COG5578	integral membrane protein
CG450_RS05995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG450_RS06005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG450_RS06010	COG2081	HI0933 family
CG450_RS06015	COG2244	polysaccharide biosynthetic process
CG450_RS06020	COG1187	pseudouridine synthase activity
CG450_RS06025	COG1349	DNA-binding transcription factor activity
CG450_RS06030	COG2252	PERMEase
CG450_RS06035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG450_RS06050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG450_RS06055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG450_RS06065	COG1597	lipid kinase activity
CG450_RS06070	COG1523	belongs to the glycosyl hydrolase 13 family
CG450_RS06075	COG0510	thiamine kinase activity
CG450_RS06085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG450_RS06090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS06095	COG0281	malic enzyme
CG450_RS06100	COG5584	Small secreted protein
CG450_RS06105	COG1363	Peptidase, m42
CG450_RS06115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS06120	COG4848	Belongs to the UPF0354 family
CG450_RS06125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG450_RS06130	COG1674	ftsk spoiiie
CG450_RS06135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG450_RS06140	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CG450_RS06145	COG4980	gas vesicle protein
CG450_RS06150	COG3118	belongs to the thioredoxin family
CG450_RS06160	COG1605	Chorismate mutase
CG450_RS06160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG450_RS06165	COG1609	Transcriptional regulator
CG450_RS06170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG450_RS06175	COG1360	Flagellar Motor Protein
CG450_RS06180	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG450_RS06185	COG0517	IMP dehydrogenase activity
CG450_RS06190	COG0454	-acetyltransferase
CG450_RS06195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG450_RS06200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG450_RS06205	COG1522	sequence-specific DNA binding
CG450_RS06210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG450_RS06215	COG3152	Membrane
CG450_RS06230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG450_RS06240	COG2203	Gaf domain
CG450_RS06240	COG2199	diguanylate cyclase activity
CG450_RS06245	COG1956	GAF domain-containing protein
CG450_RS06250	COG1309	transcriptional regulator
CG450_RS06255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG450_RS06260	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG450_RS06265	COG1114	Component of the transport system for branched-chain amino acids
CG450_RS06270	COG1104	cysteine desulfurase activity
CG450_RS06275	COG0301	tRNA thio-modification
CG450_RS06285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG450_RS06295	COG0477	Major facilitator Superfamily
CG450_RS06300	COG1566	PFAM secretion protein HlyD family protein
CG450_RS06305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG450_RS06310	COG0616	signal peptide processing
CG450_RS06315	COG1714	RDD family
CG450_RS06325	COG3874	Sporulation protein YtfJ
CG450_RS06330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG450_RS06335	COG0827	DNA restriction-modification system
CG450_RS06340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG450_RS06345	COG0521	Mo-molybdopterin cofactor biosynthetic process
CG450_RS06350	COG0137	argininosuccinate synthase activity
CG450_RS06355	COG0165	Argininosuccinate lyase
CG450_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS06365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG450_RS06370	COG4974	Belongs to the 'phage' integrase family
CG450_RS06375	COG2856	Zn peptidase
CG450_RS06395	COG3620	sequence-specific DNA binding
CG450_RS06410	COG3617	BRO family, N-terminal domain
CG450_RS06430	COG5377	YqaJ viral recombinase family
CG450_RS06435	COG3723	Recombinational DNA repair protein, rece pathway
CG450_RS06450	COG1846	Transcriptional regulator
CG450_RS06455	COG1484	DNA-dependent DNA replication
CG450_RS06495	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CG450_RS06510	COG0629	single-stranded DNA binding
CG450_RS06650	COG4824	toxin secretion phage lysis holin
CG450_RS06660	COG1695	Transcriptional regulator
CG450_RS06665	COG4109	DRTGG domain
CG450_RS06675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG450_RS06695	COG0587	DNA-directed DNA polymerase activity
CG450_RS06700	COG0281	malic enzyme
CG450_RS06705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG450_RS06710	COG0825	malonyl-CoA metabolic process
CG450_RS06715	COG0205	6-phosphofructokinase activity
CG450_RS06725	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG450_RS06730	COG0628	permease
CG450_RS06735	COG2707	UPF0756 membrane protein
CG450_RS06740	COG0372	Belongs to the citrate synthase family
CG450_RS06745	COG0538	isocitrate dehydrogenase activity
CG450_RS06750	COG0039	L-malate dehydrogenase activity
CG450_RS06755	COG0745	RESPONSE REGULATOR receiver
CG450_RS06760	COG5002	protein histidine kinase activity
CG450_RS06765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG450_RS06765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG450_RS06770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CG450_RS06775	COG1971	Probably functions as a manganese efflux pump
CG450_RS06780	COG0237	dephospho-CoA kinase activity
CG450_RS06785	COG3866	Pectate lyase
CG450_RS06790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG450_RS06795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG450_RS06810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG450_RS06815	COG3611	Membrane attachment protein
CG450_RS06820	COG1484	DNA-dependent DNA replication
CG450_RS06825	COG0398	Pfam SNARE associated Golgi protein
CG450_RS06835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG450_RS06840	COG1011	Hydrolase
CG450_RS06850	COG3275	phosphorelay sensor kinase activity
CG450_RS06855	COG3279	Response regulator of the LytR AlgR family
CG450_RS06860	COG3540	Alkaline phosphatase
CG450_RS06870	COG1346	cytolysis
CG450_RS06875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG450_RS06880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG450_RS06885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG450_RS06890	COG3326	Membrane
CG450_RS06900	COG1363	Peptidase, m42
CG450_RS06905	COG3507	Belongs to the glycosyl hydrolase 43 family
CG450_RS06915	COG1069	ribulokinase activity
CG450_RS06920	COG0235	Class ii aldolase
CG450_RS06925	COG0371	Dehydrogenase
CG450_RS06930	COG1653	transport
CG450_RS06935	COG1175	transmembrane transport
CG450_RS06940	COG0395	ABC-type sugar transport system, permease component
CG450_RS06955	COG1966	Carbon starvation protein
CG450_RS06965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG450_RS06970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG450_RS06975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG450_RS06975	COG0072	phenylalanine-tRNA ligase activity
CG450_RS06990	COG1137	ATPase activity
CG450_RS07015	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG450_RS07020	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG450_RS07025	COG1286	toxin biosynthetic process
CG450_RS07030	COG1796	DNA polymerase
CG450_RS07030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG450_RS07035	COG1193	negative regulation of DNA recombination
CG450_RS07040	COG3766	membrane
CG450_RS07045	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS07050	COG1309	transcriptional regulator
CG450_RS07055	COG1024	Enoyl-CoA hydratase
CG450_RS07060	COG2086	electron transfer activity
CG450_RS07065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG450_RS07070	COG3118	belongs to the thioredoxin family
CG450_RS07075	COG0322	excinuclease ABC activity
CG450_RS07080	COG0527	aspartate kinase activity
CG450_RS07085	COG1719	4-vinyl reductase, 4VR
CG450_RS07090	COG2009	succinate dehydrogenase
CG450_RS07095	COG1053	succinate dehydrogenase
CG450_RS07100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG450_RS07105	COG0824	Thioesterase
CG450_RS07110	COG4221	oxidoreductase activity
CG450_RS07115	COG2197	response regulator
CG450_RS07120	COG1846	Transcriptional regulator
CG450_RS07125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CG450_RS07130	COG5401	PFAM Sporulation and spore germination
CG450_RS07135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG450_RS07140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CG450_RS07145	COG0622	Phosphoesterase
CG450_RS07165	COG0457	Tetratricopeptide repeat
CG450_RS07170	COG5444	nuclease activity
CG450_RS07215	COG1783	phage Terminase large subunit
CG450_RS07220	COG5518	Phage portal protein
CG450_RS07240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG450_RS07250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG450_RS07255	COG0028	Belongs to the TPP enzyme family
CG450_RS07260	COG0440	acetolactate synthase activity
CG450_RS07265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG450_RS07270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG450_RS07275	COG0473	3-isopropylmalate dehydrogenase activity
CG450_RS07280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG450_RS07285	COG0066	3-isopropylmalate dehydratase activity
CG450_RS07290	COG1477	protein flavinylation
CG450_RS07290	COG0457	Tetratricopeptide repeat
CG450_RS07295	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG450_RS07300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG450_RS07305	COG0470	DNA polymerase III
CG450_RS07305	COG1067	ATP-dependent peptidase activity
CG450_RS07310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CG450_RS07315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG450_RS07325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG450_RS07330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG450_RS07335	COG0181	hydroxymethylbilane synthase activity
CG450_RS07340	COG1587	Uroporphyrinogen-III synthase
CG450_RS07345	COG0113	porphobilinogen synthase activity
CG450_RS07350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG450_RS07355	COG1388	LysM domain
CG450_RS07360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG450_RS07370	COG0525	valine-tRNA ligase activity
CG450_RS07375	COG0285	dihydrofolate synthase activity
CG450_RS07380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG450_RS07390	COG0424	maF-like protein
CG450_RS07395	COG2003	Belongs to the UPF0758 family
CG450_RS07410	COG1396	sequence-specific DNA binding
CG450_RS07590	COG1705	Flagellar rod assembly protein muramidase FlgJ
CG450_RS07655	COG2003	Belongs to the UPF0758 family
CG450_RS07660	COG1077	Cell shape determining protein MreB Mrl
CG450_RS07670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CG450_RS07675	COG0850	regulation of cytokinetic process
CG450_RS07680	COG2894	cell division
CG450_RS07685	COG0640	Transcriptional regulator
CG450_RS07690	COG3832	glyoxalase III activity
CG450_RS07695	COG0739	heme binding
CG450_RS07700	COG1994	Peptidase M50
CG450_RS07705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CG450_RS07710	COG2868	ribosomal protein
CG450_RS07715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG450_RS07720	COG3290	protein histidine kinase activity
CG450_RS07725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CG450_RS07730	COG4492	Belongs to the UPF0735 family
CG450_RS07735	COG0077	Prephenate dehydratase
CG450_RS07740	COG1827	regulation of RNA biosynthetic process
CG450_RS07745	COG1104	cysteine desulfurase activity
CG450_RS07750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG450_RS07755	COG0157	Belongs to the NadC ModD family
CG450_RS07760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG450_RS07765	COG1388	LysM domain
CG450_RS07775	COG0217	transcriptional regulatory protein
CG450_RS07790	COG4195	phage-related replication protein
CG450_RS07795	COG2318	DinB family
CG450_RS07805	COG2112	serine threonine protein kinase
CG450_RS07815	COG0632	four-way junction helicase activity
CG450_RS07820	COG2255	four-way junction helicase activity
CG450_RS07830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG450_RS07835	COG0343	queuine tRNA-ribosyltransferase activity
CG450_RS07840	COG1862	Preprotein translocase
CG450_RS07850	COG2323	membrane
CG450_RS07855	COG2244	polysaccharide biosynthetic process
CG450_RS07865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG450_RS07865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG450_RS07870	COG5416	Lipopolysaccharide assembly protein A domain
CG450_RS07875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG450_RS07875	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG450_RS07880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG450_RS07885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG450_RS07890	COG1490	D-aminoacyl-tRNA deacylase activity
CG450_RS07895	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS07895	COG4991	sh3 domain protein
CG450_RS07895	COG3103	Sh3 type 3 domain protein
CG450_RS07905	COG0124	histidyl-tRNA synthetase
CG450_RS07910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG450_RS07920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG450_RS07925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG450_RS07930	COG1959	2 iron, 2 sulfur cluster binding
CG450_RS07935	COG1104	cysteine desulfurase activity
CG450_RS07940	COG0482	sulfurtransferase activity
CG450_RS07945	COG0457	Tetratricopeptide repeat
CG450_RS07950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG450_RS07955	COG3881	PFAM PRC-barrel domain
CG450_RS07970	COG0628	permease
CG450_RS07975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG450_RS07980	COG4472	Bacterial protein of unknown function (DUF965)
CG450_RS07985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG450_RS07990	COG3906	Belongs to the UPF0473 family
CG450_RS07995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG450_RS08000	COG4122	O-methyltransferase activity
CG450_RS08005	COG0826	peptidase U32
CG450_RS08010	COG0826	peptidase U32
CG450_RS08015	COG0572	uridine kinase
CG450_RS08020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG450_RS08025	COG0768	penicillin binding
CG450_RS08040	COG2226	methyltransferase
CG450_RS08045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG450_RS08050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG450_RS08055	COG0626	cystathionine gamma-synthase activity
CG450_RS08080	COG2226	methyltransferase
CG450_RS08085	COG1404	Belongs to the peptidase S8 family
CG450_RS08090	COG1309	transcriptional regulator
CG450_RS08095	COG2124	cytochrome p450
CG450_RS08095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CG450_RS08105	COG2814	Major facilitator Superfamily
CG450_RS08110	COG0583	DNA-binding transcription factor activity
CG450_RS08115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS08125	COG1587	Uroporphyrinogen-III synthase
CG450_RS08130	COG3340	Belongs to the peptidase S51 family
CG450_RS08135	COG1733	regulation of RNA biosynthetic process
CG450_RS08145	COG0656	L-ascorbic acid biosynthetic process
CG450_RS08150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG450_RS08155	COG2169	Transcriptional regulator
CG450_RS08180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS08185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS08190	COG3715	PTS system
CG450_RS08195	COG3716	PTS system mannose fructose sorbose family IID component
CG450_RS08200	COG1621	beta-fructofuranosidase activity
CG450_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS08220	COG0730	response to heat
CG450_RS08225	COG2124	cytochrome p450
CG450_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS08260	COG4608	Belongs to the ABC transporter superfamily
CG450_RS08265	COG0444	Belongs to the ABC transporter superfamily
CG450_RS08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG450_RS08275	COG0601	transmembrane transport
CG450_RS08280	COG0747	negative chemotaxis
CG450_RS08285	COG0492	ferredoxin-NADP+ reductase activity
CG450_RS08290	COG2197	response regulator
CG450_RS08295	COG4585	Histidine kinase
CG450_RS08300	COG3239	Fatty acid desaturase
CG450_RS08305	COG1733	regulation of RNA biosynthetic process
CG450_RS08310	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CG450_RS08315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CG450_RS08320	COG0113	porphobilinogen synthase activity
CG450_RS08325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG450_RS08365	COG1937	Protein conserved in bacteria
CG450_RS08370	COG2210	Belongs to the sulfur carrier protein TusA family
CG450_RS08375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG450_RS08375	COG0425	Belongs to the sulfur carrier protein TusA family
CG450_RS08380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS08380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG450_RS08385	COG0425	Belongs to the sulfur carrier protein TusA family
CG450_RS08390	COG0730	response to heat
CG450_RS08395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS08400	COG4585	Histidine kinase
CG450_RS08405	COG2197	response regulator
CG450_RS08415	COG0425	Belongs to the sulfur carrier protein TusA family
CG450_RS08415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG450_RS08470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS08505	COG2427	Protein of unknown function (DUF1641)
CG450_RS08510	COG3383	formate dehydrogenase (NAD+) activity
CG450_RS08515	COG5609	conserved protein (DUF2294)
CG450_RS08520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS08525	COG2755	lipolytic protein G-D-S-L family
CG450_RS08535	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG450_RS08540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG450_RS08545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG450_RS08550	COG1534	Rna-binding protein
CG450_RS08555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG450_RS08560	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG450_RS08565	COG0799	negative regulation of ribosome biogenesis
CG450_RS08570	COG2226	methyltransferase
CG450_RS08575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG450_RS08580	COG1596	polysaccharide export
CG450_RS08580	COG1555	photosystem II stabilization
CG450_RS08585	COG2131	deaminase
CG450_RS08590	COG2333	competence protein COMEC
CG450_RS08590	COG0658	competence protein
CG450_RS08600	COG1466	dna polymerase III delta subunit
CG450_RS08605	COG0268	Binds directly to 16S ribosomal RNA
CG450_RS08610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CG450_RS08615	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS08625	COG0481	GTPase activity
CG450_RS08630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG450_RS08635	COG1420	regulation of RNA biosynthetic process
CG450_RS08640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG450_RS08645	COG0443	Heat shock 70 kDa protein
CG450_RS08650	COG0484	heat shock protein binding
CG450_RS08655	COG2264	protein methyltransferase activity
CG450_RS08660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG450_RS08665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG450_RS08670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG450_RS08675	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG450_RS08680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG450_RS08685	COG1610	YqeY-like protein
CG450_RS08690	COG1030	water channel activity
CG450_RS08695	COG4864	UPF0365 protein
CG450_RS08710	COG0561	phosphatase activity
CG450_RS08715	COG1702	phosphate starvation-inducible protein PhoH
CG450_RS08720	COG1480	7TM receptor with intracellular HD hydrolase
CG450_RS08725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG450_RS08730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG450_RS08735	COG0295	cytidine deaminase activity
CG450_RS08740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG450_RS08750	COG1381	Involved in DNA repair and RecF pathway recombination
CG450_RS08755	COG0752	glycyl-tRNA synthetase alpha subunit
CG450_RS08760	COG0751	glycine-tRNA ligase activity
CG450_RS08765	COG0517	IMP dehydrogenase activity
CG450_RS08770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG450_RS08775	COG1671	Belongs to the UPF0178 family
CG450_RS08780	COG0358	DNA primase activity
CG450_RS08785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG450_RS08790	COG2010	Cytochrome c
CG450_RS08805	COG5444	nuclease activity
CG450_RS08855	COG2384	SAM-dependent methyltransferase
CG450_RS08860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG450_RS08865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG450_RS08875	COG0513	Belongs to the DEAD box helicase family
CG450_RS08880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG450_RS08890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS08895	COG1121	(ABC) transporter
CG450_RS08900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG450_RS08905	COG0735	belongs to the Fur family
CG450_RS08910	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CG450_RS08915	COG4709	membrane
CG450_RS08920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG450_RS08925	COG1388	LysM domain
CG450_RS08930	COG5521	maltodextrose utilization protein MalA
CG450_RS08935	COG2839	Protein conserved in bacteria
CG450_RS08940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG450_RS08945	COG0477	Major facilitator Superfamily
CG450_RS08950	COG0768	penicillin binding
CG450_RS08955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG450_RS08960	COG0573	inorganic phosphate transmembrane transporter activity
CG450_RS08965	COG0581	inorganic phosphate transmembrane transporter activity
CG450_RS08970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG450_RS08975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG450_RS08980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG450_RS08995	COG0438	transferase activity, transferring glycosyl groups
CG450_RS09000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG450_RS09005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG450_RS09020	COG0697	spore germination
CG450_RS09025	COG4483	Protein conserved in bacteria
CG450_RS09030	COG1940	carbohydrate kinase activity
CG450_RS09035	COG1368	sulfuric ester hydrolase activity
CG450_RS09040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG450_RS09045	COG2866	Carboxypeptidase
CG450_RS09055	COG0011	TIGRFAM Protein of
CG450_RS09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS09075	COG1393	Belongs to the ArsC family
CG450_RS09085	COG1366	Belongs to the anti-sigma-factor antagonist family
CG450_RS09090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG450_RS09095	COG1459	type II secretion system
CG450_RS09100	COG4537	Required for transformation and DNA binding
CG450_RS09105	COG4970	Tfp pilus assembly protein FimT
CG450_RS09115	COG4940	Competence protein ComGF
CG450_RS09140	COG0681	Belongs to the peptidase S26 family
CG450_RS09165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG450_RS09170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG450_RS09175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG450_RS09180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG450_RS09185	COG0517	IMP dehydrogenase activity
CG450_RS09185	COG4175	Glycine betaine
CG450_RS09190	COG4176	ABC-type proline glycine betaine transport system permease component
CG450_RS09195	COG2113	Glycine betaine
CG450_RS09200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG450_RS09205	COG0095	Lipoate-protein ligase
CG450_RS09210	COG1321	iron dependent repressor
CG450_RS09215	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG450_RS09225	COG3872	metal-dependent enzyme
CG450_RS09235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG450_RS09240	COG0006	proline dipeptidase activity
CG450_RS09245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG450_RS09255	COG3854	ATPases associated with a variety of cellular activities
CG450_RS09295	COG0511	ligase activity, forming carbon-carbon bonds
CG450_RS09300	COG0439	Biotin carboxylase
CG450_RS09305	COG1302	Protein conserved in bacteria
CG450_RS09310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG450_RS09315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG450_RS09320	COG1570	exodeoxyribonuclease VII activity
CG450_RS09325	COG1722	exodeoxyribonuclease VII activity
CG450_RS09330	COG0142	geranyltranstransferase activity
CG450_RS09335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG450_RS09340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG450_RS09345	COG1438	arginine binding
CG450_RS09350	COG0497	DNA recombination
CG450_RS09355	COG0750	zinc metalloprotease
CG450_RS09360	COG0745	RESPONSE REGULATOR receiver
CG450_RS09370	COG1045	serine acetyltransferase
CG450_RS09385	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS09390	COG0584	glycerophosphoryl diester phosphodiesterase
CG450_RS09400	COG3290	protein histidine kinase activity
CG450_RS09400	COG3829	transcription factor binding
CG450_RS09405	COG0280	phosphate acetyltransferase
CG450_RS09415	COG3426	butyrate kinase activity
CG450_RS09420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG450_RS09425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG450_RS09430	COG0022	dehydrogenase e1 component
CG450_RS09435	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG450_RS09440	COG1597	lipid kinase activity
CG450_RS09450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG450_RS09455	COG0765	amino acid transport
CG450_RS09460	COG1126	abc transporter atp-binding protein
CG450_RS09465	COG4129	membrane
CG450_RS09470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG450_RS09475	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG450_RS09480	COG0706	membrane insertase activity
CG450_RS09490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG450_RS09495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CG450_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS09505	COG1785	Belongs to the alkaline phosphatase family
CG450_RS09510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS09515	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG450_RS09520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS09525	COG2723	6-phospho-beta-galactosidase activity
CG450_RS09530	COG2188	Transcriptional regulator
CG450_RS09535	COG2358	TRAP transporter, solute receptor (TAXI family
CG450_RS09550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CG450_RS09555	COG1234	tRNA 3'-trailer cleavage
CG450_RS09560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG450_RS09565	COG0596	Alpha beta hydrolase
CG450_RS09570	COG1902	pentaerythritol trinitrate reductase activity
CG450_RS09575	COG4187	Peptidase family M20/M25/M40
CG450_RS09580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG450_RS09585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS09590	COG0300	oxidoreductase activity
CG450_RS09600	COG4195	phage-related replication protein
CG450_RS09620	COG1131	(ABC) transporter
CG450_RS09635	COG1072	(Pantothenic acid kinase))
CG450_RS09640	COG0346	lactoylglutathione lyase activity
CG450_RS09645	COG2211	Major facilitator Superfamily
CG450_RS09655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG450_RS09670	COG0534	Mate efflux family protein
CG450_RS09680	COG0444	Belongs to the ABC transporter superfamily
CG450_RS09690	COG0601	transmembrane transport
CG450_RS09695	COG0747	negative chemotaxis
CG450_RS09705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CG450_RS09715	COG2329	Antibiotic biosynthesis monooxygenase
CG450_RS09720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG450_RS09720	COG0456	acetyltransferase
CG450_RS09730	COG4918	Iron-sulphur cluster biosynthesis
CG450_RS09740	COG1073	alpha beta
CG450_RS09750	COG0667	Aldo Keto reductase
CG450_RS09760	COG1309	transcriptional regulator
CG450_RS09770	COG0494	nUDIX hydrolase
CG450_RS09775	COG1379	DNA repair
CG450_RS09780	COG2153	protein acetylation
CG450_RS09800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS09805	COG1300	Membrane
CG450_RS09810	COG0735	belongs to the Fur family
CG450_RS09820	COG4974	Belongs to the 'phage' integrase family
CG450_RS09825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CG450_RS09830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CG450_RS09835	COG1686	Belongs to the peptidase S11 family
CG450_RS09870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG450_RS09885	COG0697	spore germination
CG450_RS09895	COG0019	diaminopimelate decarboxylase activity
CG450_RS09900	COG4195	phage-related replication protein
CG450_RS09905	COG4086	secreted protein
CG450_RS09910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG450_RS09915	COG0457	Tetratricopeptide repeat
CG450_RS09940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG450_RS09940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG450_RS09945	COG0307	riboflavin synthase, alpha
CG450_RS09950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG450_RS09950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG450_RS09955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CG450_RS09960	COG0456	acetyltransferase
CG450_RS09965	COG1547	Domain of unknown function (DUF309)
CG450_RS09975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG450_RS09980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG450_RS09990	COG1686	Belongs to the peptidase S11 family
CG450_RS09995	COG2715	membrane protein required for spore maturation
CG450_RS10000	COG0700	Nucleoside recognition
CG450_RS10005	COG1187	pseudouridine synthase activity
CG450_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS10015	COG1333	cytochrome c biogenesis protein
CG450_RS10020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG450_RS10025	COG0745	RESPONSE REGULATOR receiver
CG450_RS10030	COG5002	protein histidine kinase activity
CG450_RS10040	COG5002	protein histidine kinase activity
CG450_RS10055	COG1316	TRANSCRIPTIONal
CG450_RS10060	COG1595	DNA-templated transcription, initiation
CG450_RS10075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG450_RS10080	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG450_RS10085	COG1141	Ferredoxin
CG450_RS10090	COG4955	Helix-turn-helix domain
CG450_RS10095	COG0514	ATP-dependent DNA helicase (RecQ)
CG450_RS10100	COG1266	CAAX protease self-immunity
CG450_RS10105	COG1388	LysM domain
CG450_RS10115	COG1408	metallophosphoesterase
CG450_RS10120	COG4862	establishment of competence for transformation
CG450_RS10125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG450_RS10130	COG0492	ferredoxin-NADP+ reductase activity
CG450_RS10140	COG2339	peptidase activity
CG450_RS10145	COG3409	Peptidoglycan-binding domain 1 protein
CG450_RS10145	COG3773	Cell wall hydrolase
CG450_RS10150	COG2959	enzyme of heme biosynthesis
CG450_RS10160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG450_RS10165	COG0539	negative regulation of cytoplasmic translation
CG450_RS10170	COG1304	FMN binding
CG450_RS10195	COG1160	GTP binding
CG450_RS10200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG450_RS10220	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG450_RS10225	COG0776	regulation of translation
CG450_RS10240	COG0142	geranyltranstransferase activity
CG450_RS10245	COG2226	methyltransferase
CG450_RS10250	COG0142	geranyltranstransferase activity
CG450_RS10255	COG0105	UTP biosynthetic process
CG450_RS10260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG450_RS10265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG450_RS10270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG450_RS10275	COG4401	Chorismate mutase type I
CG450_RS10280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG450_RS10285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CG450_RS10290	COG0134	indole-3-glycerol-phosphate synthase activity
CG450_RS10295	COG0135	phosphoribosylanthranilate isomerase activity
CG450_RS10300	COG0133	tryptophan synthase activity
CG450_RS10305	COG0159	tryptophan synthase activity
CG450_RS10310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG450_RS10315	COG0287	Prephenate dehydrogenase
CG450_RS10320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG450_RS10325	COG0457	Tetratricopeptide repeat
CG450_RS10330	COG5582	Belongs to the UPF0302 family
CG450_RS10340	COG0723	plastoquinol--plastocyanin reductase activity
CG450_RS10345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG450_RS10350	COG2010	Cytochrome c
CG450_RS10350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG450_RS10355	COG4347	Protein of unknown function (DUF1405)
CG450_RS10365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS10370	COG1694	Mazg nucleotide pyrophosphohydrolase
CG450_RS10375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG450_RS10380	COG1803	Methylglyoxal synthase
CG450_RS10385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG450_RS10390	COG0438	transferase activity, transferring glycosyl groups
CG450_RS10395	COG0617	tRNA 3'-terminal CCA addition
CG450_RS10410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG450_RS10415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG450_RS10420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG450_RS10425	COG1199	ATP-dependent helicase activity
CG450_RS10425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG450_RS10435	COG5353	protein conserved in bacteria
CG450_RS10440	COG0436	Aminotransferase
CG450_RS10445	COG0017	Asparaginyl-tRNA synthetase
CG450_RS10450	COG3935	DnaD domain protein
CG450_RS10455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG450_RS10465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG450_RS10465	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG450_RS10470	COG3331	DNA recombination
CG450_RS10505	COG0071	Belongs to the small heat shock protein (HSP20) family
CG450_RS10510	COG2190	(PTS) system
CG450_RS10515	COG1205	dead DEAH box helicase
CG450_RS10515	COG1111	helicase
CG450_RS10520	COG3359	exonuclease
CG450_RS10530	COG4474	Belongs to the UPF0398 family
CG450_RS10535	COG3599	regulation of cell shape
CG450_RS10545	COG0116	Belongs to the methyltransferase superfamily
CG450_RS10560	COG1199	ATP-dependent helicase activity
CG450_RS10565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG450_RS10570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG450_RS10575	COG2233	PERMEase
CG450_RS10580	COG0456	acetyltransferase
CG450_RS10585	COG3424	synthase
CG450_RS10590	COG1755	Isoprenylcysteine carboxyl methyltransferase
CG450_RS10600	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG450_RS10615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG450_RS10625	COG0328	RNA-DNA hybrid ribonuclease activity
CG450_RS10630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CG450_RS10635	COG0328	RNA-DNA hybrid ribonuclease activity
CG450_RS10655	COG1278	Cold shock
CG450_RS10665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG450_RS10670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG450_RS10675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CG450_RS10680	COG0386	Belongs to the glutathione peroxidase family
CG450_RS10685	COG1418	mRNA catabolic process
CG450_RS10690	COG1413	lyase activity
CG450_RS10695	COG0129	dihydroxy-acid dehydratase activity
CG450_RS10705	COG2521	methyltransferase
CG450_RS10705	COG2136	Putative SAM-dependent methyltransferase
CG450_RS10715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG450_RS10720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CG450_RS10725	COG0204	Acyl-transferase
CG450_RS10730	COG1272	protein, Hemolysin III
CG450_RS10735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG450_RS10740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG450_RS10755	COG1999	signal sequence binding
CG450_RS10760	COG2755	lipolytic protein G-D-S-L family
CG450_RS10765	COG4698	Protein conserved in bacteria
CG450_RS10780	COG0534	Mate efflux family protein
CG450_RS10785	COG3706	GGDEF domain
CG450_RS10795	COG1846	Transcriptional regulator
CG450_RS10800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG450_RS10805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG450_RS10810	COG0456	acetyltransferase
CG450_RS10825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG450_RS10830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG450_RS10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG450_RS10840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG450_RS10845	COG0456	acetyltransferase
CG450_RS10850	COG1509	lysine 2,3-aminomutase activity
CG450_RS10860	COG4479	Belongs to the UPF0346 family
CG450_RS10880	COG0671	phosphoesterase, PA-phosphatase related
CG450_RS10900	COG0701	Predicted permease
CG450_RS10905	COG0813	purine-nucleoside phosphorylase activity
CG450_RS10910	COG1876	peptidase activity
CG450_RS10920	COG2226	methyltransferase
CG450_RS10925	COG0793	Belongs to the peptidase S41A family
CG450_RS10925	COG3409	Peptidoglycan-binding domain 1 protein
CG450_RS10930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS10940	COG0400	carboxylic ester hydrolase activity
CG450_RS10945	COG0778	Nitroreductase
CG450_RS10950	COG1733	regulation of RNA biosynthetic process
CG450_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS10965	COG4305	rare lipoprotein A
CG450_RS10975	COG2962	Rard protein
CG450_RS10985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG450_RS10990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG450_RS10995	COG0534	Mate efflux family protein
CG450_RS11005	COG0791	NLP P60 protein
CG450_RS11005	COG1388	LysM domain
CG450_RS11010	COG2032	superoxide dismutase activity
CG450_RS11015	COG0714	Associated with various cellular activities
CG450_RS11020	COG4548	von Willebrand factor, type A
CG450_RS11025	COG0567	Dehydrogenase, E1 component
CG450_RS11030	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG450_RS11035	COG0385	Bile acid
CG450_RS11040	COG0733	neurotransmitter:sodium symporter activity
CG450_RS11050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG450_RS11055	COG1657	PFAM Prenyltransferase squalene oxidase
CG450_RS11070	COG2814	Major facilitator Superfamily
CG450_RS11075	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS11090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG450_RS11095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CG450_RS11100	COG2318	DinB family
CG450_RS11115	COG1309	transcriptional regulator
CG450_RS11120	COG3848	Pyruvate phosphate dikinase
CG450_RS11120	COG0574	Belongs to the PEP-utilizing enzyme family
CG450_RS11130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CG450_RS11135	COG1280	lysine exporter protein (LysE YggA)
CG450_RS11150	COG2267	carboxylic ester hydrolase activity
CG450_RS11165	COG0402	S-adenosylhomocysteine deaminase activity
CG450_RS11235	COG3383	formate dehydrogenase (NAD+) activity
CG450_RS11240	COG2427	Protein of unknown function (DUF1641)
CG450_RS11260	COG2315	Protein conserved in bacteria
CG450_RS11280	COG0514	ATP-dependent DNA helicase (RecQ)
CG450_RS11285	COG3584	3D domain protein
CG450_RS11285	COG1388	LysM domain
CG450_RS11290	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS11305	COG2322	membrane
CG450_RS11325	COG1086	Polysaccharide biosynthesis protein
CG450_RS11330	COG0741	lytic transglycosylase activity
CG450_RS11335	COG0531	amino acid
CG450_RS11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS11350	COG0640	Transcriptional regulator
CG450_RS11360	COG2378	regulation of single-species biofilm formation
CG450_RS11370	COG3708	Transcriptional regulator
CG450_RS11375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS11380	COG1309	transcriptional regulator
CG450_RS11410	COG1846	Transcriptional regulator
CG450_RS11415	COG1309	transcriptional regulator
CG450_RS11425	COG1404	Belongs to the peptidase S8 family
CG450_RS11430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG450_RS11435	COG0840	transmembrane signaling receptor activity
CG450_RS11440	COG0488	(ABC) transporter
CG450_RS11450	COG0697	spore germination
CG450_RS11455	COG0531	amino acid
CG450_RS11460	COG0531	amino acid
CG450_RS11480	COG1846	Transcriptional regulator
CG450_RS11485	COG0243	molybdopterin cofactor binding
CG450_RS11490	COG0477	Major facilitator Superfamily
CG450_RS11500	COG3848	Pyruvate phosphate dikinase
CG450_RS11500	COG0574	Belongs to the PEP-utilizing enzyme family
CG450_RS11505	COG0300	oxidoreductase activity
CG450_RS11515	COG1132	(ABC) transporter
CG450_RS11525	COG1846	Transcriptional regulator
CG450_RS11545	COG0583	DNA-binding transcription factor activity
CG450_RS11550	COG0067	glutamate synthase
CG450_RS11550	COG0069	glutamate synthase activity
CG450_RS11550	COG0070	glutamate synthase
CG450_RS11555	COG0493	'glutamate synthase
CG450_RS11570	COG0463	Glycosyl transferase, family 2
CG450_RS11575	COG2814	Major facilitator Superfamily
CG450_RS11585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS11590	COG1809	phosphosulfolactate synthase activity
CG450_RS11595	COG0175	sulfate reduction
CG450_RS11600	COG0306	phosphate transporter
CG450_RS11610	COG2323	membrane
CG450_RS11620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CG450_RS11625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CG450_RS11630	COG1733	regulation of RNA biosynthetic process
CG450_RS11635	COG2249	NAD(P)H dehydrogenase (quinone) activity
CG450_RS11640	COG1960	acyl-CoA dehydrogenase activity
CG450_RS11645	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS11650	COG0439	Biotin carboxylase
CG450_RS11655	COG0511	ligase activity, forming carbon-carbon bonds
CG450_RS11660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG450_RS11665	COG1024	Enoyl-CoA hydratase
CG450_RS11670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG450_RS11675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG450_RS11685	COG0166	Belongs to the GPI family
CG450_RS11700	COG1252	NADH dehydrogenase
CG450_RS11705	COG2027	D-alanyl-D-alanine carboxypeptidase
CG450_RS11715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG450_RS11725	COG1649	PFAM Uncharacterised BCR, COG1649
CG450_RS11740	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CG450_RS11750	COG0640	Transcriptional regulator
CG450_RS11755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG450_RS11760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG450_RS11765	COG1609	Transcriptional regulator
CG450_RS11775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CG450_RS11790	COG1312	Catalyzes the dehydration of D-mannonate
CG450_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS11800	COG1725	Transcriptional regulator
CG450_RS11815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS11815	COG3711	transcriptional antiterminator
CG450_RS11835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS11835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS11835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS11840	COG1482	cell wall glycoprotein biosynthetic process
CG450_RS11845	COG1960	acyl-CoA dehydrogenase activity
CG450_RS11850	COG2084	Dehydrogenase
CG450_RS11855	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS11860	COG1024	Enoyl-CoA hydratase
CG450_RS11885	COG0789	Transcriptional regulator
CG450_RS11890	COG1064	alcohol dehydrogenase
CG450_RS11895	COG1114	Component of the transport system for branched-chain amino acids
CG450_RS11900	COG3420	alginic acid biosynthetic process
CG450_RS11915	COG0492	ferredoxin-NADP+ reductase activity
CG450_RS11925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS11935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CG450_RS11945	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CG450_RS11965	COG2223	nitrite transmembrane transporter activity
CG450_RS11970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG450_RS11980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG450_RS11985	COG0535	radical SAM domain protein
CG450_RS12000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG450_RS12005	COG1140	nitrate reductase beta subunit
CG450_RS12010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG450_RS12015	COG2181	nitrate reductase activity
CG450_RS12025	COG1115	amino acid carrier protein
CG450_RS12045	COG2160	L-arabinose isomerase activity
CG450_RS12060	COG1609	Transcriptional regulator
CG450_RS12065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG450_RS12070	COG0187	DNA topoisomerase II activity
CG450_RS12075	COG1832	CoA-binding protein
CG450_RS12080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG450_RS12085	COG4841	protein insertion into membrane
CG450_RS12110	COG0824	Thioesterase
CG450_RS12130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS12135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG450_RS12150	COG0071	Belongs to the small heat shock protein (HSP20) family
CG450_RS12160	COG4846	Membrane protein involved in cytochrome C biogenesis
CG450_RS12165	COG2201	protein-glutamate methylesterase activity
CG450_RS12170	COG0785	Cytochrome C biogenesis protein
CG450_RS12180	COG3763	UPF0154 protein
CG450_RS12190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CG450_RS12195	COG4224	UPF0291 protein
CG450_RS12200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG450_RS12205	COG1388	LysM domain
CG450_RS12210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG450_RS12215	COG3209	COG3209 Rhs family protein
CG450_RS12235	COG0655	NAD(P)H dehydrogenase (quinone) activity
CG450_RS12240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG450_RS12245	COG0346	lactoylglutathione lyase activity
CG450_RS12250	COG0778	Nitroreductase
CG450_RS12255	COG1846	Transcriptional regulator
CG450_RS12280	COG3546	catalase activity
CG450_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS12300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS12305	COG2076	Multidrug Resistance protein
CG450_RS12310	COG2076	Multidrug Resistance protein
CG450_RS12315	COG1309	transcriptional regulator
CG450_RS12355	COG1073	alpha beta
CG450_RS12400	COG0174	glutamine synthetase
CG450_RS12405	COG0789	Transcriptional regulator
CG450_RS12410	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG450_RS12415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG450_RS12420	COG0464	growth
CG450_RS12475	COG1309	transcriptional regulator
CG450_RS12510	COG0697	spore germination
CG450_RS12515	COG1802	Transcriptional regulator
CG450_RS12520	COG0735	belongs to the Fur family
CG450_RS12535	COG4112	unkown
CG450_RS12540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG450_RS12545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG450_RS12550	COG1780	Probably involved in ribonucleotide reductase function
CG450_RS12565	COG1923	regulation of RNA biosynthetic process
CG450_RS12570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG450_RS12585	COG2076	Multidrug Resistance protein
CG450_RS12590	COG2076	Multidrug Resistance protein
CG450_RS12595	COG1764	response to oxidative stress
CG450_RS12605	COG0702	epimerase
CG450_RS12610	COG3631	Ketosteroid isomerase-related protein
CG450_RS12615	COG1309	transcriptional regulator
CG450_RS12620	COG1388	LysM domain
CG450_RS12620	COG3858	chitin binding
CG450_RS12630	COG5577	PFAM Coat F domain
CG450_RS12635	COG0531	amino acid
CG450_RS12640	COG1819	glycosyl
CG450_RS12645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG450_RS12650	COG0398	Pfam SNARE associated Golgi protein
CG450_RS12655	COG0393	Putative heavy-metal-binding
CG450_RS12665	COG2267	carboxylic ester hydrolase activity
CG450_RS12670	COG2267	carboxylic ester hydrolase activity
CG450_RS12675	COG2814	Major facilitator Superfamily
CG450_RS12680	COG3263	regulation of cellular component size
CG450_RS12685	COG3619	membrane
CG450_RS12690	COG1231	oxidoreductase activity
CG450_RS12705	COG1247	-acetyltransferase
CG450_RS12715	COG0523	cobalamin synthesis protein
CG450_RS12735	COG5444	nuclease activity
CG450_RS12740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CG450_RS12745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG450_RS12750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG450_RS12760	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG450_RS12765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG450_RS12770	COG0156	8-amino-7-oxononanoate synthase activity
CG450_RS12775	COG1063	alcohol dehydrogenase
CG450_RS12785	COG2359	stage V sporulation protein S
CG450_RS12790	COG1692	metallophosphoesterase
CG450_RS12795	COG1418	mRNA catabolic process
CG450_RS12805	COG1546	Belongs to the CinA family
CG450_RS12805	COG1058	Belongs to the CinA family
CG450_RS12810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG450_RS12815	COG1426	Protein conserved in bacteria
CG450_RS12830	COG0300	oxidoreductase activity
CG450_RS12835	COG0612	Peptidase, M16
CG450_RS12840	COG0612	Peptidase, M16
CG450_RS12845	COG2814	Major facilitator Superfamily
CG450_RS12850	COG2188	Transcriptional regulator
CG450_RS12855	COG1674	ftsk spoiiie
CG450_RS12855	COG4980	gas vesicle protein
CG450_RS12865	COG0740	serine-type endopeptidase activity
CG450_RS12870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG450_RS12880	COG0527	aspartate kinase activity
CG450_RS12885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG450_RS12890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG450_RS12895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG450_RS12900	COG1873	PFAM PRC-barrel domain
CG450_RS12905	COG0612	Peptidase, M16
CG450_RS12910	COG0726	polysaccharide deacetylase
CG450_RS12915	COG1185	polyribonucleotide nucleotidyltransferase activity
CG450_RS12920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CG450_RS12925	COG0196	riboflavin kinase activity
CG450_RS12930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG450_RS12935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG450_RS12940	COG1550	Protein conserved in bacteria
CG450_RS12945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG450_RS12950	COG1358	cellular component organization or biogenesis
CG450_RS12955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG450_RS12960	COG0195	Participates in both transcription termination and antitermination
CG450_RS12965	COG0779	Required for maturation of 30S ribosomal subunits
CG450_RS12995	COG2176	DNA-directed DNA polymerase activity
CG450_RS13000	COG0442	prolyl-tRNA aminoacylation
CG450_RS13005	COG0750	zinc metalloprotease
CG450_RS13010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CG450_RS13015	COG4589	Belongs to the CDS family
CG450_RS13020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CG450_RS13025	COG0233	cytoplasmic translational termination
CG450_RS13030	COG0528	UMP kinase activity
CG450_RS13035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG450_RS13040	COG0052	Belongs to the universal ribosomal protein uS2 family
CG450_RS13050	COG1191	sigma factor activity
CG450_RS13055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CG450_RS13060	COG1776	CheC inhibitor of MCP methylation
CG450_RS13065	COG0835	chemotaxis
CG450_RS13070	COG2198	Histidine kinase
CG450_RS13070	COG0643	Histidine kinase
CG450_RS13075	COG2201	protein-glutamate methylesterase activity
CG450_RS13080	COG0455	bacterial-type flagellum organization
CG450_RS13085	COG1419	protein localization to endoplasmic reticulum
CG450_RS13090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG450_RS13095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG450_RS13100	COG1684	flagellar biosynthetic protein fliR
CG450_RS13105	COG1987	bacterial-type flagellum assembly
CG450_RS13110	COG1338	Plays a role in the flagellum-specific transport system
CG450_RS13115	COG3190	flagellar
CG450_RS13120	COG2201	protein-glutamate methylesterase activity
CG450_RS13125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG450_RS13125	COG1776	CheC inhibitor of MCP methylation
CG450_RS13130	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG450_RS13135	COG1580	Controls the rotational direction of flagella during chemotaxis
CG450_RS13140	COG1582	Flagellar protein (FlbD)
CG450_RS13145	COG4786	Flagellar basal body rod
CG450_RS13150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CG450_RS13155	COG3144	bacterial-type flagellum assembly
CG450_RS13165	COG2882	bacterial-type flagellum organization
CG450_RS13170	COG1157	protein secretion by the type III secretion system
CG450_RS13175	COG1317	bacterial-type flagellum organization
CG450_RS13180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG450_RS13185	COG1766	The M ring may be actively involved in energy transduction
CG450_RS13190	COG1677	Flagellar hook-basal body complex protein FliE
CG450_RS13195	COG1558	bacterial-type flagellum-dependent cell motility
CG450_RS13200	COG1815	bacterial-type flagellum-dependent cell motility
CG450_RS13205	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG450_RS13210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG450_RS13215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG450_RS13220	COG4974	Belongs to the 'phage' integrase family
CG450_RS13225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG450_RS13230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG450_RS13235	COG0758	DNA mediated transformation
CG450_RS13240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG450_RS13245	COG0045	succinate-CoA ligase (ADP-forming) activity
CG450_RS13250	COG2257	FlhB HrpN YscU SpaS Family
CG450_RS13260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG450_RS13265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG450_RS13270	COG0335	large ribosomal subunit rRNA binding
CG450_RS13275	COG0336	Belongs to the RNA methyltransferase TrmD family
CG450_RS13280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG450_RS13290	COG1837	Belongs to the UPF0109 family
CG450_RS13295	COG0228	four-way junction DNA binding
CG450_RS13300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG450_RS13305	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG450_RS13310	COG0552	protein localization to endoplasmic reticulum
CG450_RS13315	COG1196	nuclear chromosome segregation
CG450_RS13320	COG0571	ribonuclease III activity
CG450_RS13325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG450_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS13335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG450_RS13340	COG0416	fatty acid biosynthetic process
CG450_RS13345	COG1349	DNA-binding transcription factor activity
CG450_RS13350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG450_RS13355	COG1760	l-serine dehydratase
CG450_RS13360	COG1760	l-serine dehydratase
CG450_RS13365	COG1461	Dihydroxyacetone kinase
CG450_RS13370	COG1302	Protein conserved in bacteria
CG450_RS13375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG450_RS13385	COG1564	THIamine pyrophosphokinase
CG450_RS13390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG450_RS13395	COG1162	GTPase activity
CG450_RS13400	COG0515	serine threonine protein kinase
CG450_RS13400	COG2815	serine threonine protein kinase
CG450_RS13405	COG0631	protein serine/threonine phosphatase activity
CG450_RS13410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG450_RS13415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG450_RS13415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG450_RS13420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG450_RS13425	COG0242	peptide deformylase activity
CG450_RS13430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG450_RS13435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG450_RS13440	COG1758	RNA polymerase activity
CG450_RS13445	COG0194	GDP metabolic process
CG450_RS13450	COG2052	Domain of unknown function (DUF370)
CG450_RS13455	COG1561	YicC-like family, N-terminal region
CG450_RS13460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG450_RS13470	COG1648	precorrin-2 dehydrogenase activity
CG450_RS13475	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CG450_RS13480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG450_RS13485	COG0529	Catalyzes the synthesis of activated sulfate
CG450_RS13490	COG2046	Belongs to the sulfate adenylyltransferase family
CG450_RS13495	COG0306	phosphate transporter
CG450_RS13500	COG0175	sulfate reduction
CG450_RS13510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG450_RS13515	COG0284	orotidine-5'-phosphate decarboxylase activity
CG450_RS13520	COG0167	dihydroorotate dehydrogenase activity
CG450_RS13525	COG0543	2 iron, 2 sulfur cluster binding
CG450_RS13530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG450_RS13535	COG0505	Belongs to the CarA family
CG450_RS13540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG450_RS13545	COG0540	Belongs to the ATCase OTCase family
CG450_RS13550	COG2233	PERMEase
CG450_RS13555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG450_RS13560	COG0564	pseudouridine synthase activity
CG450_RS13565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG450_RS13570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG450_RS13575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG450_RS13580	COG3599	regulation of cell shape
CG450_RS13585	COG2302	S4 RNA-binding domain
CG450_RS13590	COG0762	integral membrane protein
CG450_RS13595	COG1799	cell septum assembly
CG450_RS13600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG450_RS13605	COG1496	oxidoreductase activity
CG450_RS13610	COG1873	PFAM PRC-barrel domain
CG450_RS13615	COG0500	methyltransferase
CG450_RS13620	COG1119	ATPase activity
CG450_RS13625	COG1191	sigma factor activity
CG450_RS13630	COG1191	sigma factor activity
CG450_RS13640	COG1404	Belongs to the peptidase S8 family
CG450_RS13640	COG4412	M6 family metalloprotease domain protein
CG450_RS13645	COG1404	Belongs to the peptidase S8 family
CG450_RS13645	COG4412	M6 family metalloprotease domain protein
CG450_RS13650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG450_RS13655	COG0849	cell division
CG450_RS13660	COG3856	small basic protein
CG450_RS13665	COG3879	Bacterial protein of unknown function (DUF881)
CG450_RS13670	COG3879	Bacterial protein of unknown function (DUF881)
CG450_RS13675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG450_RS13680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CG450_RS13685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG450_RS13690	COG0772	Belongs to the SEDS family
CG450_RS13695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG450_RS13700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG450_RS13705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG450_RS13710	COG0768	penicillin binding
CG450_RS13715	COG0768	penicillin binding
CG450_RS13720	COG4839	cell division protein FtsL
CG450_RS13725	COG0275	rRNA processing
CG450_RS13730	COG2001	Belongs to the MraZ family
CG450_RS13735	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG450_RS13740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG450_RS13745	COG0454	-acetyltransferase
CG450_RS13755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CG450_RS13760	COG1399	metal-binding, possibly nucleic acid-binding protein
CG450_RS13765	COG1323	Belongs to the UPF0348 family
CG450_RS13770	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG450_RS13775	COG3314	Sporulation integral membrane protein YlbJ
CG450_RS13780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG450_RS13785	COG0742	ribosomal rna small subunit methyltransferase
CG450_RS13790	COG4471	UPF0298 protein
CG450_RS13795	COG3679	Belongs to the UPF0342 family
CG450_RS13810	COG2340	Cysteine-rich secretory protein family
CG450_RS13815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG450_RS13825	COG3336	cytochrome c oxidase
CG450_RS13830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CG450_RS13835	COG1845	cytochrome c oxidase, subunit III
CG450_RS13840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG450_RS13845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG450_RS13845	COG2010	Cytochrome c
CG450_RS13850	COG0109	protoheme IX farnesyltransferase activity
CG450_RS13855	COG1612	heme a metabolic process
CG450_RS13860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG450_RS13865	COG0772	Belongs to the SEDS family
CG450_RS13870	COG4838	Belongs to the UPF0358 family
CG450_RS13875	COG2066	Belongs to the glutaminase family
CG450_RS13880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG450_RS13885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG450_RS13895	COG4896	Protein conserved in bacteria
CG450_RS13900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CG450_RS13905	COG1846	Transcriptional regulator
CG450_RS13915	COG1217	gtp-binding protein TYPA
CG450_RS13930	COG1595	DNA-templated transcription, initiation
CG450_RS13950	COG0483	inositol monophosphate 1-phosphatase activity
CG450_RS13960	COG4493	Belongs to the UPF0637 family
CG450_RS13965	COG4476	Belongs to the UPF0223 family
CG450_RS13975	COG1982	Orn Lys Arg decarboxylase major
CG450_RS13985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS13990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG450_RS13995	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG450_RS14000	COG0022	dehydrogenase e1 component
CG450_RS14005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG450_RS14010	COG0497	DNA recombination
CG450_RS14020	COG0242	peptide deformylase activity
CG450_RS14025	COG0561	phosphatase activity
CG450_RS14030	COG5503	Protein of unknown function (DUF1447)
CG450_RS14035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG450_RS14040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CG450_RS14045	COG0569	domain protein
CG450_RS14050	COG3852	Histidine kinase
CG450_RS14055	COG2002	toxin-antitoxin pair type II binding
CG450_RS14060	COG1077	Cell shape determining protein MreB Mrl
CG450_RS14070	COG2309	aminopeptidase activity
CG450_RS14080	COG0488	(ABC) transporter
CG450_RS14100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS14100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS14100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG450_RS14105	COG1105	Belongs to the carbohydrate kinase PfkB family
CG450_RS14110	COG1349	DNA-binding transcription factor activity
CG450_RS14115	COG0577	efflux transmembrane transporter activity
CG450_RS14120	COG1136	(ABC) transporter
CG450_RS14125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CG450_RS14135	COG1132	(ABC) transporter
CG450_RS14140	COG1132	(ABC) transporter
CG450_RS14150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CG450_RS14155	COG0314	molybdopterin synthase activity
CG450_RS14160	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG450_RS14165	COG0303	'Molybdopterin
CG450_RS14170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG450_RS14175	COG0746	molybdenum cofactor guanylyltransferase activity
CG450_RS14190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS14195	COG0450	alkyl hydroperoxide reductase
CG450_RS14205	COG1473	amidohydrolase
CG450_RS14210	COG2171	N-acyltransferase activity
CG450_RS14215	COG0716	FMN binding
CG450_RS14225	COG0716	FMN binding
CG450_RS14230	COG0583	DNA-binding transcription factor activity
CG450_RS14235	COG0517	IMP dehydrogenase activity
CG450_RS14245	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG450_RS14255	COG4703	Protein of unknown function (DUF1797)
CG450_RS14265	COG2200	EAL domain
CG450_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS14275	COG1408	metallophosphoesterase
CG450_RS14285	COG1376	ErfK ybiS ycfS ynhG family protein
CG450_RS14290	COG2814	Major facilitator Superfamily
CG450_RS14300	COG0835	chemotaxis
CG450_RS14300	COG0784	Response regulator, receiver
CG450_RS14310	COG1714	RDD family
CG450_RS14315	COG0436	Aminotransferase
CG450_RS14320	COG4191	Histidine kinase
CG450_RS14325	COG0768	penicillin binding
CG450_RS14330	COG2340	Cysteine-rich secretory protein family
CG450_RS14335	COG2084	Dehydrogenase
CG450_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS14345	COG0840	transmembrane signaling receptor activity
CG450_RS14350	COG0456	acetyltransferase
CG450_RS14355	COG1533	DNA photolyase activity
CG450_RS14365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CG450_RS14370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS14375	COG2190	(PTS) system
CG450_RS14375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS14375	COG1263	PTS System
CG450_RS14380	COG3711	transcriptional antiterminator
CG450_RS14385	COG1609	Transcriptional regulator
CG450_RS14395	COG0006	proline dipeptidase activity
CG450_RS14400	COG2217	Heavy metal translocating P-type atpase
CG450_RS14405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS14410	COG2244	polysaccharide biosynthetic process
CG450_RS14415	COG3773	Cell wall hydrolase
CG450_RS14435	COG4873	Protein conserved in bacteria
CG450_RS14465	COG3655	Transcriptional regulator
CG450_RS14470	COG3739	integral membrane protein
CG450_RS14480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG450_RS14485	COG0582	viral genome integration into host DNA
CG450_RS14510	COG3409	Peptidoglycan-binding domain 1 protein
CG450_RS14510	COG1388	LysM domain
CG450_RS14510	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG450_RS14640	COG0582	viral genome integration into host DNA
CG450_RS14725	COG5444	nuclease activity
CG450_RS14780	COG4974	Belongs to the 'phage' integrase family
CG450_RS14785	COG4974	Belongs to the 'phage' integrase family
CG450_RS14795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG450_RS14800	COG0602	queuosine metabolic process
CG450_RS14805	COG0720	synthase
CG450_RS14810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG450_RS14815	COG3949	Membrane
CG450_RS14820	COG0542	response to heat
CG450_RS14825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG450_RS14830	COG1360	Flagellar Motor Protein
CG450_RS14835	COG1846	Transcriptional regulator
CG450_RS14840	COG3852	Histidine kinase
CG450_RS14850	COG3339	Conserved Protein
CG450_RS14855	COG0346	lactoylglutathione lyase activity
CG450_RS14860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG450_RS14865	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG450_RS14865	COG0235	Class ii aldolase
CG450_RS14870	COG1850	ribulose-bisphosphate carboxylase activity
CG450_RS14875	COG0436	Aminotransferase
CG450_RS14880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG450_RS14885	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG450_RS14890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG450_RS14895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG450_RS14900	COG5002	protein histidine kinase activity
CG450_RS14905	COG3594	Acyltransferase
CG450_RS14920	COG0768	penicillin binding
CG450_RS14925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG450_RS14930	COG0501	Belongs to the peptidase M48B family
CG450_RS14950	COG1191	sigma factor activity
CG450_RS14955	COG0861	Integral membrane protein TerC family
CG450_RS14960	COG0586	Pfam SNARE associated Golgi protein
CG450_RS14965	COG5001	Diguanylate cyclase
CG450_RS14965	COG3300	MHYT domain
CG450_RS14970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CG450_RS14975	COG1793	dna ligase
CG450_RS14975	COG3285	dna ligase
CG450_RS14980	COG1846	Transcriptional regulator
CG450_RS14995	COG0789	Transcriptional regulator
CG450_RS15005	COG2239	Acts as a magnesium transporter
CG450_RS15015	COG1404	Belongs to the peptidase S8 family
CG450_RS15020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG450_RS15035	COG0406	alpha-ribazole phosphatase activity
CG450_RS15040	COG0590	tRNA wobble adenosine to inosine editing
CG450_RS15050	COG1764	response to oxidative stress
CG450_RS15055	COG1846	Transcriptional regulator
CG450_RS15060	COG1764	response to oxidative stress
CG450_RS15065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CG450_RS15070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CG450_RS15075	COG0788	formyltetrahydrofolate deformylase activity
CG450_RS15080	COG2076	Multidrug Resistance protein
CG450_RS15085	COG2076	Multidrug Resistance protein
CG450_RS15090	COG2318	DinB family
CG450_RS15110	COG3866	Pectate lyase
CG450_RS15115	COG2323	membrane
CG450_RS15120	COG1607	acyl-coa hydrolase
CG450_RS15125	COG1834	amidinotransferase
CG450_RS15130	COG4608	Belongs to the ABC transporter superfamily
CG450_RS15135	COG0791	NLP P60 protein
CG450_RS15140	COG4948	Mandelate Racemase Muconate Lactonizing
CG450_RS15145	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG450_RS15150	COG4166	transmembrane transport
CG450_RS15155	COG0444	Belongs to the ABC transporter superfamily
CG450_RS15160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG450_RS15165	COG0601	transmembrane transport
CG450_RS15170	COG2362	D-Aminopeptidase
CG450_RS15175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG450_RS15180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG450_RS15190	COG0346	lactoylglutathione lyase activity
CG450_RS15195	COG0531	amino acid
CG450_RS15200	COG0395	ABC-type sugar transport system, permease component
CG450_RS15205	COG4209	transmembrane transport
CG450_RS15210	COG1653	transport
CG450_RS15220	COG1874	Beta-galactosidase
CG450_RS15225	COG2755	lipolytic protein G-D-S-L family
CG450_RS15230	COG0667	Aldo Keto reductase
CG450_RS15235	COG3401	FG-GAP repeat protein
CG450_RS15240	COG2755	lipolytic protein G-D-S-L family
CG450_RS15250	COG3401	FG-GAP repeat protein
CG450_RS15255	COG5578	integral membrane protein
CG450_RS15265	COG2755	lipolytic protein G-D-S-L family
CG450_RS15270	COG2207	Transcriptional regulator
CG450_RS15275	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CG450_RS15280	COG0395	ABC-type sugar transport system, permease component
CG450_RS15285	COG1175	transmembrane transport
CG450_RS15290	COG1653	transport
CG450_RS15295	COG4753	response regulator
CG450_RS15295	COG2207	Transcriptional regulator
CG450_RS15300	COG2972	Histidine kinase
CG450_RS15310	COG0405	Gamma-glutamyltransferase
CG450_RS15315	COG1392	Phosphate transport regulator
CG450_RS15320	COG0306	phosphate transporter
CG450_RS15335	COG2271	Major facilitator Superfamily
CG450_RS15340	COG1063	alcohol dehydrogenase
CG450_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS15350	COG1312	Catalyzes the dehydration of D-mannonate
CG450_RS15355	COG1063	alcohol dehydrogenase
CG450_RS15360	COG1802	Transcriptional regulator
CG450_RS15395	COG3778	Protein conserved in bacteria
CG450_RS15400	COG3299	homolog of phage Mu protein gp47
CG450_RS15405	COG3628	GPW Gp25 family protein
CG450_RS15415	COG4193	domain, Protein
CG450_RS15420	COG1652	LysM domain
CG450_RS15425	COG5412	phage tail tape measure protein
CG450_RS15425	COG3953	SLT domain
CG450_RS15475	COG4653	Phage capsid family
CG450_RS15480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CG450_RS15485	COG5518	Phage portal protein
CG450_RS15490	COG1783	phage Terminase large subunit
CG450_RS15495	COG5484	DNA packaging
CG450_RS15495	COG3728	DNA packaging
CG450_RS15500	COG1595	DNA-templated transcription, initiation
CG450_RS15515	COG1484	DNA-dependent DNA replication
CG450_RS15520	COG1522	sequence-specific DNA binding
CG450_RS15535	COG1396	sequence-specific DNA binding
CG450_RS15540	COG2856	Zn peptidase
CG450_RS15545	COG4195	phage-related replication protein
CG450_RS15570	COG1309	transcriptional regulator
CG450_RS15575	COG2814	Major facilitator Superfamily
CG450_RS15580	COG1388	LysM domain
CG450_RS15580	COG3584	3D domain protein
CG450_RS15590	COG0346	lactoylglutathione lyase activity
CG450_RS15595	COG0697	spore germination
CG450_RS15600	COG0583	DNA-binding transcription factor activity
CG450_RS15605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG450_RS15610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CG450_RS15615	COG0583	DNA-binding transcription factor activity
CG450_RS15625	COG0110	maltose O-acetyltransferase activity
CG450_RS15645	COG3507	Belongs to the glycosyl hydrolase 43 family
CG450_RS15665	COG5505	Protein of unknown function (DUF819)
CG450_RS15670	COG0626	cystathionine gamma-synthase activity
CG450_RS15675	COG0626	cystathionine gamma-synthase activity
CG450_RS15695	COG2382	esterase
CG450_RS15700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG450_RS15705	COG2153	protein acetylation
CG450_RS15710	COG2246	polysaccharide biosynthetic process
CG450_RS15715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG450_RS15720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG450_RS15725	COG0586	Pfam SNARE associated Golgi protein
CG450_RS15735	COG0210	DNA helicase
CG450_RS15790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CG450_RS15795	COG0351	phosphomethylpyrimidine kinase
CG450_RS15800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG450_RS15805	COG2022	thiamine diphosphate biosynthetic process
CG450_RS15810	COG2104	thiamine diphosphate biosynthetic process
CG450_RS15820	COG0352	thiamine-phosphate diphosphorylase activity
CG450_RS15825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG450_RS15830	COG0569	domain protein
CG450_RS15830	COG0475	glutathione-regulated potassium exporter activity
CG450_RS15840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG450_RS15845	COG0564	pseudouridine synthase activity
CG450_RS15850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG450_RS15855	COG2357	RelA SpoT domain protein
CG450_RS15865	COG4116	CYTH
CG450_RS15870	COG0741	lytic transglycosylase activity
CG450_RS15875	COG2346	COG2346, Truncated hemoglobins
CG450_RS15880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CG450_RS15890	COG1164	Oligoendopeptidase f
CG450_RS15895	COG4469	Competence protein
CG450_RS15900	COG3290	protein histidine kinase activity
CG450_RS15905	COG4565	transcriptional regulatory protein
CG450_RS15925	COG4862	establishment of competence for transformation
CG450_RS15930	COG0861	Integral membrane protein TerC family
CG450_RS15935	COG1393	Belongs to the ArsC family
CG450_RS15940	COG0456	acetyltransferase
CG450_RS15945	COG4608	Belongs to the ABC transporter superfamily
CG450_RS15950	COG0444	Belongs to the ABC transporter superfamily
CG450_RS15955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG450_RS15960	COG0601	transmembrane transport
CG450_RS15965	COG4166	transmembrane transport
CG450_RS15975	COG0180	Tryptophanyl-tRNA synthetase
CG450_RS16000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG450_RS16005	COG0601	transmembrane transport
CG450_RS16015	COG4608	Belongs to the ABC transporter superfamily
CG450_RS16020	COG0444	Belongs to the ABC transporter superfamily
CG450_RS16025	COG5504	Zn-dependent protease
CG450_RS16030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG450_RS16035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG450_RS16050	COG1744	ABC transporter substrate-binding protein PnrA-like
CG450_RS16060	COG2267	carboxylic ester hydrolase activity
CG450_RS16075	COG1968	undecaprenyl-diphosphatase activity
CG450_RS16080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CG450_RS16085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG450_RS16090	COG0505	Belongs to the CarA family
CG450_RS16095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CG450_RS16100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG450_RS16105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CG450_RS16110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG450_RS16120	COG2151	metal-sulfur cluster biosynthetic enzyme
CG450_RS16125	COG1073	alpha beta
CG450_RS16130	COG0561	phosphatase activity
CG450_RS16140	COG0516	GMP reductase activity
CG450_RS16150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS16155	COG1307	EDD domain protein, DegV family
CG450_RS16170	COG2996	Protein conserved in bacteria
CG450_RS16175	COG1666	GTP binding
CG450_RS16180	COG0646	methionine synthase
CG450_RS16180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG450_RS16185	COG1410	methionine synthase
CG450_RS16185	COG0646	methionine synthase
CG450_RS16190	COG2378	regulation of single-species biofilm formation
CG450_RS16195	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS16200	COG2153	protein acetylation
CG450_RS16225	COG0076	glutamate decarboxylase activity
CG450_RS16235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG450_RS16240	COG0673	inositol 2-dehydrogenase activity
CG450_RS16245	COG1609	Transcriptional regulator
CG450_RS16255	COG1917	Cupin 2, conserved barrel domain protein
CG450_RS16255	COG2207	Transcriptional regulator
CG450_RS16260	COG0534	Mate efflux family protein
CG450_RS16265	COG0347	Belongs to the P(II) protein family
CG450_RS16270	COG0004	ammonium transporteR
CG450_RS16275	COG0367	asparagine synthase
CG450_RS16300	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG450_RS16310	COG5337	Spore coat protein CotH
CG450_RS16355	COG0419	ATPase involved in DNA repair
CG450_RS16360	COG0420	3'-5' exonuclease activity
CG450_RS16365	COG1074	ATP-dependent DNA helicase activity
CG450_RS16370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG450_RS16375	COG4149	molybdate abc transporter
CG450_RS16380	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG450_RS16385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CG450_RS16390	COG0745	RESPONSE REGULATOR receiver
CG450_RS16395	COG5002	protein histidine kinase activity
CG450_RS16405	COG2814	Major facilitator Superfamily
CG450_RS16405	COG0477	Major facilitator Superfamily
CG450_RS16410	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS16415	COG3546	catalase activity
CG450_RS16430	COG3180	Ammonia monooxygenase
CG450_RS16435	COG1486	melibiose metabolic process
CG450_RS16440	COG0395	ABC-type sugar transport system, permease component
CG450_RS16445	COG1175	transmembrane transport
CG450_RS16450	COG1653	transport
CG450_RS16455	COG1609	Transcriptional regulator
CG450_RS16475	COG0457	Tetratricopeptide repeat
CG450_RS16485	COG2814	Major facilitator Superfamily
CG450_RS16490	COG0549	Belongs to the carbamate kinase family
CG450_RS16500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG450_RS16505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG450_RS16510	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CG450_RS16515	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CG450_RS16520	COG3257	ureidoglycine aminohydrolase activity
CG450_RS16525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG450_RS16530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG450_RS16540	COG2508	Transcriptional regulator
CG450_RS16550	COG1404	Belongs to the peptidase S8 family
CG450_RS16555	COG0681	Belongs to the peptidase S26 family
CG450_RS16560	COG0398	Pfam SNARE associated Golgi protein
CG450_RS16570	COG4903	ComK protein
CG450_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS16585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG450_RS16585	COG0723	plastoquinol--plastocyanin reductase activity
CG450_RS16590	COG0840	transmembrane signaling receptor activity
CG450_RS16595	COG0406	alpha-ribazole phosphatase activity
CG450_RS16600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS16605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS16610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG450_RS16615	COG0697	spore germination
CG450_RS16625	COG0501	Belongs to the peptidase M48B family
CG450_RS16640	COG1396	sequence-specific DNA binding
CG450_RS16650	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS16655	COG0095	Lipoate-protein ligase
CG450_RS16660	COG1234	tRNA 3'-trailer cleavage
CG450_RS16670	COG1301	dicarboxylic acid transport
CG450_RS16680	COG1363	Peptidase, m42
CG450_RS16685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG450_RS16690	COG1511	domain protein
CG450_RS16695	COG1309	transcriptional regulator
CG450_RS16700	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CG450_RS16705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CG450_RS16710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG450_RS16715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG450_RS16720	COG2329	Antibiotic biosynthesis monooxygenase
CG450_RS16725	COG3069	C4-dicarboxylate transmembrane transporter activity
CG450_RS16730	COG1473	amidohydrolase
CG450_RS16740	COG4473	ABC transporter
CG450_RS16745	COG1131	(ABC) transporter
CG450_RS16755	COG0537	adenosine 5'-monophosphoramidase activity
CG450_RS16760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CG450_RS16775	COG4980	gas vesicle protein
CG450_RS16780	COG1846	Transcriptional regulator
CG450_RS16810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CG450_RS16820	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG450_RS16825	COG4717	serine-type aminopeptidase activity
CG450_RS16830	COG0420	3'-5' exonuclease activity
CG450_RS16835	COG1668	transmembrane transport
CG450_RS16840	COG4152	abc transporter atp-binding protein
CG450_RS16855	COG0457	Tetratricopeptide repeat
CG450_RS16860	COG1024	Enoyl-CoA hydratase
CG450_RS16870	COG0490	domain, Protein
CG450_RS16875	COG0475	glutathione-regulated potassium exporter activity
CG450_RS16880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG450_RS16885	COG0561	phosphatase activity
CG450_RS16895	COG3679	Belongs to the UPF0342 family
CG450_RS16900	COG4399	Belongs to the UPF0754 family
CG450_RS16905	COG0189	ligase activity
CG450_RS16910	COG0189	ligase activity
CG450_RS16920	COG2508	Transcriptional regulator
CG450_RS16925	COG3842	ATPase activity
CG450_RS16940	COG0702	epimerase
CG450_RS16945	COG1132	(ABC) transporter
CG450_RS16950	COG1132	(ABC) transporter
CG450_RS16955	COG0589	response to stress
CG450_RS16980	COG2017	converts alpha-aldose to the beta-anomer
CG450_RS16985	COG1757	Na H antiporter
CG450_RS16995	COG0726	polysaccharide deacetylase
CG450_RS17005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CG450_RS17010	COG0668	transmembrane transport
CG450_RS17020	COG0584	glycerophosphoryl diester phosphodiesterase
CG450_RS17025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG450_RS17030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG450_RS17050	COG1253	flavin adenine dinucleotide binding
CG450_RS17055	COG0789	Transcriptional regulator
CG450_RS17060	COG1253	flavin adenine dinucleotide binding
CG450_RS17065	COG1309	transcriptional regulator
CG450_RS17075	COG3152	Membrane
CG450_RS17080	COG0204	Acyl-transferase
CG450_RS17090	COG0662	Cupin 2, conserved barrel domain protein
CG450_RS17095	COG1595	DNA-templated transcription, initiation
CG450_RS17120	COG3708	Transcriptional regulator
CG450_RS17120	COG2207	Transcriptional regulator
CG450_RS17130	COG0733	neurotransmitter:sodium symporter activity
CG450_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS17140	COG2133	pyrroloquinoline quinone binding
CG450_RS17145	COG0372	Belongs to the citrate synthase family
CG450_RS17150	COG0583	DNA-binding transcription factor activity
CG450_RS17155	COG0791	NLP P60 protein
CG450_RS17155	COG1388	LysM domain
CG450_RS17160	COG2719	SpoVR family
CG450_RS17165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CG450_RS17165	COG1017	nitric oxide dioxygenase activity
CG450_RS17170	COG1959	2 iron, 2 sulfur cluster binding
CG450_RS17185	COG0431	NADPH-dependent FMN reductase
CG450_RS17190	COG2197	response regulator
CG450_RS17195	COG4585	Histidine kinase
CG450_RS17195	COG2203	Gaf domain
CG450_RS17210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG450_RS17215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG450_RS17220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG450_RS17225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG450_RS17230	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG450_RS17235	COG0604	alcohol dehydrogenase
CG450_RS17240	COG0679	Auxin Efflux Carrier
CG450_RS17245	COG2116	formate transmembrane transporter activity
CG450_RS17255	COG0488	(ABC) transporter
CG450_RS17260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG450_RS17260	COG3153	acetyltransferase
CG450_RS17265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG450_RS17270	COG0517	IMP dehydrogenase activity
CG450_RS17280	COG0564	pseudouridine synthase activity
CG450_RS17285	COG3764	Sortase (surface protein transpeptidase)
CG450_RS17290	COG0737	Belongs to the 5'-nucleotidase family
CG450_RS17290	COG4085	toxin activity
CG450_RS17290	COG1525	nuclease
CG450_RS17295	COG5002	protein histidine kinase activity
CG450_RS17300	COG5577	PFAM Coat F domain
CG450_RS17325	COG1823	symporter activity
CG450_RS17330	COG1464	Belongs to the NlpA lipoprotein family
CG450_RS17335	COG2011	ABC-type metal ion transport system permease component
CG450_RS17340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CG450_RS17345	COG1278	Cold shock
CG450_RS17350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG450_RS17355	COG1131	(ABC) transporter
CG450_RS17360	COG1131	(ABC) transporter
CG450_RS17380	COG0655	NAD(P)H dehydrogenase (quinone) activity
CG450_RS17385	COG2814	Major facilitator Superfamily
CG450_RS17390	COG1566	PFAM secretion protein HlyD family protein
CG450_RS17395	COG2718	Belongs to the UPF0229 family
CG450_RS17400	COG2766	serine protein kinase
CG450_RS17410	COG1664	Polymer-forming cytoskeletal
CG450_RS17415	COG0789	Transcriptional regulator
CG450_RS17420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG450_RS17430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CG450_RS17435	COG3382	B3 4 domain protein
CG450_RS17445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CG450_RS17465	COG1131	(ABC) transporter
CG450_RS17475	COG1476	TRANSCRIPTIONal
CG450_RS17485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG450_RS17490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG450_RS17495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG450_RS17500	COG1116	anion transmembrane transporter activity
CG450_RS17505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG450_RS17510	COG0710	3-dehydroquinate dehydratase activity
CG450_RS17520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG450_RS17525	COG0457	Tetratricopeptide repeat
CG450_RS17530	COG5444	nuclease activity
CG450_RS17545	COG5444	nuclease activity
CG450_RS17590	COG0457	Tetratricopeptide repeat
CG450_RS17700	COG0735	belongs to the Fur family
CG450_RS17705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG450_RS17710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG450_RS17715	COG4129	membrane
CG450_RS17720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG450_RS17725	COG0601	transmembrane transport
CG450_RS17730	COG0747	negative chemotaxis
CG450_RS17735	COG4608	Belongs to the ABC transporter superfamily
CG450_RS17740	COG0444	Belongs to the ABC transporter superfamily
CG450_RS17745	COG1132	(ABC) transporter
CG450_RS17750	COG3557	Belongs to the UPF0374 family
CG450_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS17775	COG1194	a g-specific adenine glycosylase
CG450_RS17780	COG1988	membrane-bound metal-dependent
CG450_RS17785	COG4485	Bacterial membrane protein, YfhO
CG450_RS17795	COG0463	Glycosyl transferase, family 2
CG450_RS17825	COG2137	regulation of response to DNA damage stimulus
CG450_RS17830	COG1090	epimerase
CG450_RS17850	COG0778	Nitroreductase
CG450_RS17855	COG0384	phenazine biosynthesis protein PhzF
CG450_RS17880	COG1051	belongs to the nudix hydrolase family
CG450_RS17885	COG2249	NAD(P)H dehydrogenase (quinone) activity
CG450_RS17890	COG1653	transport
CG450_RS17895	COG2207	Transcriptional regulator
CG450_RS17895	COG1917	Cupin 2, conserved barrel domain protein
CG450_RS17900	COG3507	Belongs to the glycosyl hydrolase 43 family
CG450_RS17905	COG3507	Belongs to the glycosyl hydrolase 43 family
CG450_RS17910	COG2514	catechol 2,3-dioxygenase activity
CG450_RS17915	COG2259	Doxx family
CG450_RS17920	COG1733	regulation of RNA biosynthetic process
CG450_RS17935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS17935	COG1263	PTS System
CG450_RS17940	COG1737	Transcriptional regulator
CG450_RS17945	COG1486	melibiose metabolic process
CG450_RS17950	COG1742	UPF0060 membrane protein
CG450_RS17955	COG3284	Transcriptional regulator
CG450_RS17960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG450_RS17965	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG450_RS17970	COG0022	dehydrogenase e1 component
CG450_RS17975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG450_RS17985	COG5609	conserved protein (DUF2294)
CG450_RS17990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG450_RS17995	COG3002	Belongs to the UPF0753 family
CG450_RS18000	COG0288	reversible hydration of carbon dioxide
CG450_RS18005	COG3711	transcriptional antiterminator
CG450_RS18010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS18010	COG1263	PTS System
CG450_RS18015	COG0477	Major facilitator Superfamily
CG450_RS18025	COG1819	glycosyl
CG450_RS18050	COG4637	Psort location Cytoplasmic, score
CG450_RS18055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG450_RS18060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG450_RS18065	COG0598	Magnesium transport protein CorA
CG450_RS18075	COG0371	Dehydrogenase
CG450_RS18080	COG0726	polysaccharide deacetylase
CG450_RS18090	COG0535	radical SAM domain protein
CG450_RS18100	COG0387	Pfam Sodium calcium exchanger
CG450_RS18110	COG0477	Major facilitator Superfamily
CG450_RS18115	COG1295	ribonuclease BN
CG450_RS18120	COG4980	gas vesicle protein
CG450_RS18125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG450_RS18130	COG1115	amino acid carrier protein
CG450_RS18135	COG4840	Belongs to the UPF0435 family
CG450_RS18140	COG0693	protein deglycase activity
CG450_RS18145	COG0737	Belongs to the 5'-nucleotidase family
CG450_RS18150	COG0778	Nitroreductase
CG450_RS18155	COG1733	regulation of RNA biosynthetic process
CG450_RS18160	COG0657	acetylesterase activity
CG450_RS18170	COG0673	inositol 2-dehydrogenase activity
CG450_RS18180	COG0463	Glycosyl transferase, family 2
CG450_RS18180	COG0457	Tetratricopeptide repeat
CG450_RS18185	COG1215	transferase activity, transferring glycosyl groups
CG450_RS18195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG450_RS18200	COG1045	serine acetyltransferase
CG450_RS18205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CG450_RS18230	COG2188	Transcriptional regulator
CG450_RS18235	COG0366	Alpha amylase catalytic
CG450_RS18240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS18240	COG1263	PTS System
CG450_RS18245	COG1115	amino acid carrier protein
CG450_RS18255	COG1368	sulfuric ester hydrolase activity
CG450_RS18260	COG0024	Methionine aminopeptidase
CG450_RS18275	COG2258	MOSC domain
CG450_RS18280	COG1254	Belongs to the acylphosphatase family
CG450_RS18285	COG0640	Transcriptional regulator
CG450_RS18290	COG5658	integral membrane protein
CG450_RS18295	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG450_RS18305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG450_RS18320	COG0471	metal ion transport
CG450_RS18335	COG2130	NADP-dependent
CG450_RS18340	COG0513	Belongs to the DEAD box helicase family
CG450_RS18345	COG0488	(ABC) transporter
CG450_RS18350	COG2814	Major facilitator Superfamily
CG450_RS18355	COG0789	Transcriptional regulator
CG450_RS18365	COG2124	cytochrome p450
CG450_RS18370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG450_RS18375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CG450_RS18380	COG0156	8-amino-7-oxononanoate synthase activity
CG450_RS18385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG450_RS18390	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CG450_RS18395	COG0523	cobalamin synthesis protein
CG450_RS18410	COG1469	GTP cyclohydrolase I activity
CG450_RS18420	COG0488	(ABC) transporter
CG450_RS18425	COG0471	metal ion transport
CG450_RS18430	COG0840	transmembrane signaling receptor activity
CG450_RS18435	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS18450	COG0217	transcriptional regulatory protein
CG450_RS18470	COG0457	Tetratricopeptide repeat
CG450_RS18475	COG3711	transcriptional antiterminator
CG450_RS18480	COG2723	6-phospho-beta-galactosidase activity
CG450_RS18485	COG1263	PTS System
CG450_RS18485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS18485	COG2190	(PTS) system
CG450_RS18495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG450_RS18500	COG1597	lipid kinase activity
CG450_RS18505	COG1957	nucleoside hydrolase
CG450_RS18510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS18520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG450_RS18525	COG1309	transcriptional regulator
CG450_RS18530	COG4124	Belongs to the glycosyl hydrolase 26 family
CG450_RS18545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG450_RS18550	COG0154	amidase activity
CG450_RS18555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG450_RS18560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS18565	COG1285	pathogenesis
CG450_RS18570	COG0363	glucosamine-6-phosphate deaminase activity
CG450_RS18575	COG3457	Alanine racemase
CG450_RS18580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CG450_RS18585	COG0626	cystathionine gamma-synthase activity
CG450_RS18590	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CG450_RS18610	COG2188	Transcriptional regulator
CG450_RS18615	COG4851	CamS sex pheromone cAM373 precursor
CG450_RS18620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG450_RS18625	COG0210	DNA helicase
CG450_RS18630	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG450_RS18635	COG4496	protein, YerC YecD
CG450_RS18640	COG1470	cell adhesion involved in biofilm formation
CG450_RS18645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CG450_RS18665	COG2124	cytochrome p450
CG450_RS18675	COG0151	Belongs to the GarS family
CG450_RS18680	COG0138	bifunctional purine biosynthesis protein purh
CG450_RS18685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG450_RS18690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG450_RS18695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG450_RS18700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG450_RS18705	COG0047	phosphoribosylformylglycinamidine synthase activity
CG450_RS18710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG450_RS18715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG450_RS18720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG450_RS18725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG450_RS18730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG450_RS18740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG450_RS18755	COG2252	PERMEase
CG450_RS18775	COG1705	Flagellar rod assembly protein muramidase FlgJ
CG450_RS18875	COG2369	cell adhesion
CG450_RS18890	COG5484	DNA packaging
CG450_RS18890	COG3728	DNA packaging
CG450_RS18925	COG0629	single-stranded DNA binding
CG450_RS18970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG450_RS18980	COG0519	Catalyzes the synthesis of GMP from XMP
CG450_RS18980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG450_RS18985	COG1305	Transglutaminase-like
CG450_RS18990	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CG450_RS18995	COG0714	Associated with various cellular activities
CG450_RS19000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG450_RS19015	COG2132	Multicopper oxidase
CG450_RS19025	COG0702	epimerase
CG450_RS19055	COG0823	Involved in the tonB-independent uptake of proteins
CG450_RS19060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CG450_RS19075	COG1846	Transcriptional regulator
CG450_RS19080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG450_RS19085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG450_RS19090	COG0366	Alpha amylase catalytic
CG450_RS19095	COG1554	hydrolase, family 65, central catalytic
CG450_RS19100	COG5521	maltodextrose utilization protein MalA
CG450_RS19105	COG3833	ABC-type maltose transport systems, permease component
CG450_RS19110	COG1175	transmembrane transport
CG450_RS19115	COG2182	Extracellular solute-binding protein
CG450_RS19120	COG0366	Alpha amylase catalytic
CG450_RS19125	COG1609	Transcriptional regulator
CG450_RS19135	COG0726	polysaccharide deacetylase
CG450_RS19160	COG0772	Belongs to the SEDS family
CG450_RS19165	COG0772	Belongs to the SEDS family
CG450_RS19170	COG3339	Conserved Protein
CG450_RS19175	COG1280	lysine exporter protein (LysE YggA)
CG450_RS19180	COG1378	Sugar-specific transcriptional regulator TrmB
CG450_RS19190	COG4260	virion core protein, lumpy skin disease virus
CG450_RS19195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CG450_RS19200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG450_RS19205	COG1842	Phage shock protein A
CG450_RS19210	COG2814	Major facilitator Superfamily
CG450_RS19215	COG2272	Belongs to the type-B carboxylesterase lipase family
CG450_RS19220	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CG450_RS19225	COG3189	MarR family transcriptional regulator
CG450_RS19235	COG0574	Belongs to the PEP-utilizing enzyme family
CG450_RS19235	COG3848	Pyruvate phosphate dikinase
CG450_RS19240	COG1309	transcriptional regulator
CG450_RS19250	COG2135	peptidase activity
CG450_RS19265	COG2720	vancomycin resistance protein
CG450_RS19295	COG0459	protein refolding
CG450_RS19300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG450_RS19305	COG1266	CAAX protease self-immunity
CG450_RS19315	COG0805	protein transport
CG450_RS19320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG450_RS19325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG450_RS19330	COG0315	cyclic pyranopterin monophosphate synthase activity
CG450_RS19335	COG0488	(ABC) transporter
CG450_RS19340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CG450_RS19345	COG0456	acetyltransferase
CG450_RS19350	COG1214	PFAM Peptidase M22, glycoprotease
CG450_RS19355	COG0802	atpase or kinase
CG450_RS19360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CG450_RS19400	COG2814	Major facilitator Superfamily
CG450_RS19405	COG3764	Sortase (surface protein transpeptidase)
CG450_RS19415	COG3279	Response regulator of the LytR AlgR family
CG450_RS19420	COG0745	RESPONSE REGULATOR receiver
CG450_RS19420	COG2972	Histidine kinase
CG450_RS19425	COG2814	Major facilitator Superfamily
CG450_RS19430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CG450_RS19430	COG2755	lipolytic protein G-D-S-L family
CG450_RS19445	COG1595	DNA-templated transcription, initiation
CG450_RS19460	COG1113	amino acid transport
CG450_RS19465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG450_RS19480	COG0583	DNA-binding transcription factor activity
CG450_RS19490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG450_RS19495	COG1733	regulation of RNA biosynthetic process
CG450_RS19505	COG2808	Putative FMN-binding domain
CG450_RS19510	COG0456	acetyltransferase
CG450_RS19515	COG1846	Transcriptional regulator
CG450_RS19520	COG2364	Membrane
CG450_RS19530	COG1063	alcohol dehydrogenase
CG450_RS19535	COG1278	Cold shock
CG450_RS19540	COG3239	Fatty acid desaturase
CG450_RS19545	COG1476	TRANSCRIPTIONal
CG450_RS19590	COG3091	SprT-like family
CG450_RS19600	COG1033	growth of symbiont in host cell
CG450_RS19600	COG2409	Drug exporters of the RND superfamily
CG450_RS19605	COG1309	transcriptional regulator
CG450_RS19610	COG2183	response to ionizing radiation
CG450_RS19615	COG2208	phosphoserine phosphatase activity
CG450_RS19620	COG1191	sigma factor activity
CG450_RS19625	COG2172	sigma factor antagonist activity
CG450_RS19635	COG2208	phosphoserine phosphatase activity
CG450_RS19640	COG2172	sigma factor antagonist activity
CG450_RS19645	COG1366	Belongs to the anti-sigma-factor antagonist family
CG450_RS19650	COG1366	Belongs to the anti-sigma-factor antagonist family
CG450_RS19655	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG450_RS19660	COG0864	Transcriptional regulator
CG450_RS19665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG450_RS19670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG450_RS19675	COG0705	Rhomboid family
CG450_RS19680	COG3428	Bacterial PH domain
CG450_RS19685	COG3402	PFAM membrane-flanked domain
CG450_RS19690	COG0513	Belongs to the DEAD box helicase family
CG450_RS19700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG450_RS19705	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG450_RS19710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG450_RS19725	COG1960	acyl-CoA dehydrogenase activity
CG450_RS19735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG450_RS19740	COG1131	(ABC) transporter
CG450_RS19745	COG1301	dicarboxylic acid transport
CG450_RS19750	COG0628	permease
CG450_RS19760	COG0662	Cupin 2, conserved barrel domain protein
CG450_RS19770	COG2217	Heavy metal translocating P-type atpase
CG450_RS19775	COG4876	unkown
CG450_RS19780	COG1819	glycosyl
CG450_RS19785	COG1027	Aspartate ammonia-lyase
CG450_RS19790	COG2261	transglycosylase associated protein
CG450_RS19795	COG1914	H( )-stimulated, divalent metal cation uptake system
CG450_RS19800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG450_RS19810	COG3397	chitin binding
CG450_RS19815	COG0028	Belongs to the TPP enzyme family
CG450_RS19820	COG0531	amino acid
CG450_RS19825	COG0551	DNA topoisomerase type I activity
CG450_RS19825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG450_RS19830	COG1522	sequence-specific DNA binding
CG450_RS19840	COG2814	Major facilitator Superfamily
CG450_RS19855	COG3871	stress protein (general stress protein 26)
CG450_RS19865	COG1917	Cupin 2, conserved barrel domain protein
CG450_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS19875	COG3711	transcriptional antiterminator
CG450_RS19880	COG0246	Mannitol dehydrogenase
CG450_RS19885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS19890	COG2213	PTS system mannitol-specific
CG450_RS19895	COG2755	lipolytic protein G-D-S-L family
CG450_RS19900	COG1414	Transcriptional regulator
CG450_RS19905	COG1984	allophanate hydrolase subunit 2
CG450_RS19910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG450_RS19915	COG4336	lyase activity
CG450_RS19920	COG1914	H( )-stimulated, divalent metal cation uptake system
CG450_RS19925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG450_RS19930	COG0561	phosphatase activity
CG450_RS19935	COG3958	Transketolase
CG450_RS19940	COG3959	Transketolase, thiamine diphosphate binding domain
CG450_RS19955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG450_RS19970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG450_RS19975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG450_RS19980	COG0471	metal ion transport
CG450_RS19985	COG1802	Transcriptional regulator
CG450_RS19990	COG1587	Uroporphyrinogen-III synthase
CG450_RS19990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG450_RS19995	COG2146	nitrite reductase [NAD(P)H] activity
CG450_RS20000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG450_RS20005	COG0243	molybdopterin cofactor binding
CG450_RS20010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG450_RS20015	COG1349	DNA-binding transcription factor activity
CG450_RS20020	COG2372	response to copper ion
CG450_RS20020	COG1276	copper resistance
CG450_RS20025	COG4549	nuclear export factor GLE1
CG450_RS20035	COG0697	spore germination
CG450_RS20040	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS20045	COG0531	amino acid
CG450_RS20050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG450_RS20055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG450_RS20060	COG0640	Transcriptional regulator
CG450_RS20065	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CG450_RS20070	COG0778	Nitroreductase
CG450_RS20080	COG1309	transcriptional regulator
CG450_RS20085	COG2814	Major facilitator Superfamily
CG450_RS20090	COG4607	ABC-type enterochelin transport system periplasmic component
CG450_RS20095	COG4604	ABC transporter, ATP-binding protein
CG450_RS20100	COG4605	iron ion homeostasis
CG450_RS20105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG450_RS20110	COG0527	aspartate kinase activity
CG450_RS20120	COG5002	protein histidine kinase activity
CG450_RS20120	COG3850	Histidine kinase
CG450_RS20125	COG0745	RESPONSE REGULATOR receiver
CG450_RS20130	COG0577	efflux transmembrane transporter activity
CG450_RS20135	COG1136	(ABC) transporter
CG450_RS20140	COG0789	Transcriptional regulator
CG450_RS20145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG450_RS20155	COG0697	spore germination
CG450_RS20165	COG5434	Belongs to the glycosyl hydrolase 28 family
CG450_RS20170	COG3104	oligopeptide transport
CG450_RS20175	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
CG450_RS20180	COG1874	Beta-galactosidase
CG450_RS20185	COG1846	Transcriptional regulator
CG450_RS20185	COG0456	acetyltransferase
CG450_RS20190	COG2271	Major facilitator Superfamily
CG450_RS20195	COG4214	carbohydrate transport
CG450_RS20205	COG4213	ABC transporter substrate-binding protein
CG450_RS20210	COG4753	response regulator
CG450_RS20210	COG2207	Transcriptional regulator
CG450_RS20215	COG2972	Histidine kinase
CG450_RS20235	COG5444	nuclease activity
CG450_RS20285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CG450_RS20290	COG0163	prenyltransferase activity
CG450_RS20295	COG0583	DNA-binding transcription factor activity
CG450_RS20300	COG0010	Belongs to the arginase family
CG450_RS20305	COG0833	amino acid
CG450_RS20310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CG450_RS20315	COG3829	transcription factor binding
CG450_RS20320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG450_RS20325	COG0765	amino acid transport
CG450_RS20330	COG1126	abc transporter atp-binding protein
CG450_RS20355	COG1131	(ABC) transporter
CG450_RS20365	COG2364	Membrane
CG450_RS20375	COG2819	hydrolase of the alpha beta superfamily
CG450_RS20385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG450_RS20390	COG0697	spore germination
CG450_RS20395	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG450_RS20400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG450_RS20405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG450_RS20410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG450_RS20415	COG1177	transmembrane transport
CG450_RS20420	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG450_RS20445	COG5444	nuclease activity
CG450_RS20450	COG0840	transmembrane signaling receptor activity
CG450_RS20450	COG3290	protein histidine kinase activity
CG450_RS20455	COG3266	domain, Protein
CG450_RS20455	COG0515	serine threonine protein kinase
CG450_RS20465	COG3209	COG3209 Rhs family protein
CG450_RS20475	COG2723	6-phospho-beta-galactosidase activity
CG450_RS20485	COG2249	NAD(P)H dehydrogenase (quinone) activity
CG450_RS20490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG450_RS20495	COG0765	amino acid transport
CG450_RS20515	COG3458	cephalosporin-C deacetylase activity
CG450_RS20520	COG0701	Predicted permease
CG450_RS20525	COG3689	TIGRFAM TIGR03943 family protein
CG450_RS20530	COG2508	Transcriptional regulator
CG450_RS20535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG450_RS20540	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS20545	COG0506	proline dehydrogenase activity
CG450_RS20550	COG3541	Predicted nucleotidyltransferase
CG450_RS20555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG450_RS20560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG450_RS20565	COG1113	amino acid transport
CG450_RS20570	COG1280	lysine exporter protein (LysE YggA)
CG450_RS20575	COG1620	l-lactate permease
CG450_RS20580	COG0039	L-malate dehydrogenase activity
CG450_RS20585	COG2223	nitrite transmembrane transporter activity
CG450_RS20590	COG0789	Transcriptional regulator
CG450_RS20600	COG0785	Cytochrome C biogenesis protein
CG450_RS20605	COG3853	Toxic anion resistance protein (TelA)
CG450_RS20625	COG0861	Integral membrane protein TerC family
CG450_RS20630	COG2310	stress, protein
CG450_RS20635	COG2310	stress, protein
CG450_RS20640	COG2310	stress, protein
CG450_RS20660	COG1309	transcriptional regulator
CG450_RS20665	COG1131	(ABC) transporter
CG450_RS20675	COG0791	NLP P60 protein
CG450_RS20675	COG3883	PFAM NLP P60 protein
CG450_RS20680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG450_RS20685	COG3773	Cell wall hydrolase
CG450_RS20695	COG1595	DNA-templated transcription, initiation
CG450_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS20710	COG3591	Belongs to the peptidase S1B family
CG450_RS20725	COG3394	polysaccharide catabolic process
CG450_RS20730	COG2188	Transcriptional regulator
CG450_RS20735	COG1486	melibiose metabolic process
CG450_RS20740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS20745	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG450_RS20750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG450_RS20755	COG0277	FAD linked oxidase domain protein
CG450_RS20760	COG0247	lactate metabolic process
CG450_RS20770	COG2261	transglycosylase associated protein
CG450_RS20775	COG1164	Oligoendopeptidase f
CG450_RS20785	COG0456	acetyltransferase
CG450_RS20795	COG1288	antiporter activity
CG450_RS20810	COG1028	Short-chain dehydrogenase reductase Sdr
CG450_RS20815	COG1942	4-Oxalocrotonate Tautomerase
CG450_RS20820	COG0583	DNA-binding transcription factor activity
CG450_RS20845	COG1131	(ABC) transporter
CG450_RS20850	COG3012	SEC-C Motif Domain Protein
CG450_RS20850	COG1405	negative regulation of cell septum assembly
CG450_RS20855	COG1714	RDD family
CG450_RS20860	COG0697	spore germination
CG450_RS20885	COG0789	Transcriptional regulator
CG450_RS20905	COG0318	PFAM AMP-dependent synthetase and ligase
CG450_RS20910	COG1846	Transcriptional regulator
CG450_RS20915	COG3173	Aminoglycoside phosphotransferase
CG450_RS20940	COG1131	(ABC) transporter
CG450_RS20945	COG2205	protein histidine kinase activity
CG450_RS20950	COG0745	RESPONSE REGULATOR receiver
CG450_RS20955	COG2721	sulfolactate sulfo-lyase activity
CG450_RS20960	COG2186	Transcriptional regulator
CG450_RS20965	COG4948	Mandelate Racemase Muconate Lactonizing
CG450_RS20970	COG2271	Major facilitator Superfamily
CG450_RS20975	COG1012	belongs to the aldehyde dehydrogenase family
CG450_RS20980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG450_RS20985	COG0805	protein transport
CG450_RS20990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG450_RS20995	COG3540	Alkaline phosphatase
CG450_RS21020	COG0784	Response regulator, receiver
CG450_RS21025	COG4191	Histidine kinase
CG450_RS21030	COG2066	Belongs to the glutaminase family
CG450_RS21035	COG1115	amino acid carrier protein
CG450_RS21045	COG2205	protein histidine kinase activity
CG450_RS21055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG450_RS21055	COG4451	ribulose bisphosphate carboxylase, small
CG450_RS21060	COG2323	membrane
CG450_RS21065	COG0789	Transcriptional regulator
CG450_RS21070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS21070	COG2190	(PTS) system
CG450_RS21070	COG1263	PTS System
CG450_RS21080	COG2040	homocysteine
CG450_RS21085	COG0833	amino acid
CG450_RS21095	COG4257	antibiotic catabolic process
CG450_RS21110	COG4213	ABC transporter substrate-binding protein
CG450_RS21115	COG0840	transmembrane signaling receptor activity
CG450_RS21120	COG0371	Dehydrogenase
CG450_RS21140	COG2207	Transcriptional regulator
CG450_RS21140	COG1917	Cupin 2, conserved barrel domain protein
CG450_RS21145	COG0697	spore germination
CG450_RS21170	COG4682	membrane
CG450_RS21175	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG450_RS21195	COG0477	Major facilitator Superfamily
CG450_RS21205	COG1331	Highly conserved protein containing a thioredoxin domain
CG450_RS21210	COG1846	Transcriptional regulator
CG450_RS21245	COG3677	Transposase
CG450_RS21250	COG1331	Highly conserved protein containing a thioredoxin domain
CG450_RS21270	COG2211	Major facilitator Superfamily
CG450_RS21285	COG3290	protein histidine kinase activity
CG450_RS21290	COG4565	transcriptional regulatory protein
CG450_RS21295	COG3181	Tripartite tricarboxylate transporter family receptor
CG450_RS21300	COG2851	Citrate transporter
CG450_RS21305	COG1113	amino acid transport
CG450_RS21310	COG1011	Hydrolase
CG450_RS21335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CG450_RS21340	COG1132	(ABC) transporter
CG450_RS21350	COG2814	Major facilitator Superfamily
CG450_RS21355	COG0640	Transcriptional regulator
CG450_RS21360	COG1725	Transcriptional regulator
CG450_RS21380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CG450_RS21385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG450_RS21390	COG4856	YbbR-like protein
CG450_RS21395	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG450_RS21400	COG5662	AntiSigma factor
CG450_RS21405	COG1595	DNA-templated transcription, initiation
CG450_RS21440	COG1683	Conserved Protein
CG450_RS21445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG450_RS21450	COG1737	Transcriptional regulator
CG450_RS21455	COG1263	PTS System
CG450_RS21455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG450_RS21460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG450_RS21465	COG1472	Belongs to the glycosyl hydrolase 3 family
CG450_RS21470	COG3876	Protein conserved in bacteria
CG450_RS21485	COG0385	Bile acid
CG450_RS21495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG450_RS21525	COG0726	polysaccharide deacetylase
CG450_RS21530	COG2194	sulfuric ester hydrolase activity
CG450_RS21540	COG0489	protein tyrosine kinase activity
CG450_RS21545	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG450_RS21555	COG2318	DinB family
CG450_RS21560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG450_RS21565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG450_RS21570	COG0101	tRNA pseudouridine synthase activity
CG450_RS21575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG450_RS21580	COG1122	ATPase activity
CG450_RS21585	COG1122	ATPase activity
CG450_RS21590	COG0203	ribosomal protein L17
CG450_RS21595	COG0202	RNA polymerase activity
CG450_RS21600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG450_RS21605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CG450_RS21610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG450_RS21615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CG450_RS21620	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CG450_RS21625	COG0024	Methionine aminopeptidase
CG450_RS21630	COG0563	adenylate kinase activity
CG450_RS21635	COG0201	protein transport
CG450_RS21640	COG0200	Binds to the 23S rRNA
CG450_RS21645	COG1841	ribosomal large subunit assembly
CG450_RS21650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG450_RS21655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG450_RS21660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG450_RS21665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG450_RS21670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CG450_RS21675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG450_RS21680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG450_RS21685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG450_RS21690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG450_RS21695	COG0255	Belongs to the universal ribosomal protein uL29 family
CG450_RS21700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG450_RS21705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG450_RS21710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG450_RS21715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG450_RS21720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG450_RS21725	COG0089	rRNA binding
CG450_RS21730	COG0088	Forms part of the polypeptide exit tunnel
CG450_RS21735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG450_RS21745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG450_RS21750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG450_RS21755	COG0049	tRNA binding
CG450_RS21760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG450_RS21765	COG1358	cellular component organization or biogenesis
CG450_RS21770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG450_RS21775	COG0085	RNA polymerase activity
CG450_RS21780	COG2813	Specifically methylates the guanine in position
CG450_RS21785	COG0222	ribosome binding
CG450_RS21790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG450_RS21795	COG0081	regulation of translation
CG450_RS21800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CG450_RS21805	COG0250	Participates in transcription elongation, termination and antitermination
CG450_RS21815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG450_RS21825	COG3688	RNA-binding protein containing a PIN domain
CG450_RS21830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG450_RS21835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CG450_RS21840	COG0215	cysteine-tRNA ligase activity
CG450_RS21845	COG1045	serine acetyltransferase
CG450_RS21850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG450_RS21855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG450_RS21860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG450_RS21865	COG4956	integral membrane protein (PIN domain superfamily)
CG450_RS21870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CG450_RS21875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG450_RS21880	COG0542	response to heat
CG450_RS21885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG450_RS21890	COG3880	PFAM UvrB UvrC protein
CG450_RS21895	COG4463	regulation of RNA biosynthetic process
CG450_RS21975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG450_RS21980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG450_RS21985	COG1396	sequence-specific DNA binding
CG450_RS21990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG450_RS21995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG450_RS22000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG450_RS22005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG450_RS22010	COG0512	Glutamine amidotransferase of anthranilate synthase
CG450_RS22015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG450_RS22025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG450_RS22030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CG450_RS22035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG450_RS22040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG450_RS22045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG450_RS22050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG450_RS22055	COG0037	tRNA processing
CG450_RS22060	COG0515	serine threonine protein kinase
CG450_RS22065	COG2304	oxidoreductase activity
CG450_RS22070	COG2208	phosphoserine phosphatase activity
CG450_RS22085	COG1098	S1 RNA binding domain
CG450_RS22090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CG450_RS22105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG450_RS22110	COG3956	TIGRFAM MazG family protein
CG450_RS22115	COG2244	polysaccharide biosynthetic process
CG450_RS22120	COG2002	toxin-antitoxin pair type II binding
CG450_RS22125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG450_RS22135	COG0193	aminoacyl-tRNA hydrolase activity
CG450_RS22140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CG450_RS22145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG450_RS22150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG450_RS22155	COG2088	sporulation resulting in formation of a cellular spore
CG450_RS22160	COG0251	oxidation-reduction process
CG450_RS22165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG450_RS22170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG450_RS22180	COG4466	Protein conserved in bacteria
CG450_RS22190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG450_RS22195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG450_RS22200	COG3583	domain protein
CG450_RS22200	COG3584	3D domain protein
CG450_RS22205	COG0084	hydrolase, TatD family'
CG450_RS22210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG450_RS22210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG450_RS22215	COG2002	toxin-antitoxin pair type II binding
CG450_RS22220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG450_RS22225	COG2827	Endonuclease containing a URI domain
CG450_RS22230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG450_RS22235	COG4467	Involved in initiation control of chromosome replication
CG450_RS22240	COG1774	PSP1 C-terminal conserved region
CG450_RS22245	COG0470	DNA polymerase III
CG450_RS22250	COG1728	Protein conserved in bacteria
CG450_RS22255	COG3870	Protein conserved in bacteria
CG450_RS22260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG450_RS22265	COG1982	Orn Lys Arg decarboxylase major
CG450_RS22270	COG3853	Toxic anion resistance protein (TelA)
CG450_RS22275	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CG450_RS22320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG450_RS22325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG450_RS22330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG450_RS22340	COG0590	tRNA wobble adenosine to inosine editing
CG450_RS22345	COG1335	isochorismatase
CG450_RS22350	COG3858	chitin binding
CG450_RS22350	COG1388	LysM domain
CG450_RS22355	COG1428	Deoxynucleoside kinase
CG450_RS22360	COG1428	Deoxynucleoside kinase
CG450_RS22375	COG3835	regulator
CG450_RS22380	COG2610	gluconate transmembrane transporter activity
CG450_RS22385	COG1929	Belongs to the glycerate kinase type-1 family
CG450_RS22390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG450_RS22395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG450_RS22400	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG450_RS22405	COG1686	Belongs to the peptidase S11 family
CG450_RS22410	COG0516	GMP reductase activity
CG450_RS22410	COG0517	IMP dehydrogenase activity
CG450_RS22445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG450_RS22450	COG0187	DNA topoisomerase II activity
CG450_RS22460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG450_RS22465	COG2501	S4 domain
CG450_RS22470	COG0592	DNA-directed DNA polymerase activity