locus-tag	class	description
IRJ22_RS00015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRJ22_RS00015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRJ22_RS00050	COG1780	Probably involved in ribonucleotide reductase function
IRJ22_RS00055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRJ22_RS00070	COG0756	dUTP diphosphatase activity
IRJ22_RS00085	COG3584	3D domain protein
IRJ22_RS00205	COG0740	serine-type endopeptidase activity
IRJ22_RS00305	COG1388	LysM domain
IRJ22_RS00305	COG3409	Peptidoglycan-binding domain 1 protein
IRJ22_RS00305	COG5632	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS00325	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS00350	COG0457	Tetratricopeptide repeat
IRJ22_RS00375	COG5444	nuclease activity
IRJ22_RS00390	COG5444	nuclease activity
IRJ22_RS00395	COG0457	Tetratricopeptide repeat
IRJ22_RS00400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRJ22_RS00410	COG0710	3-dehydroquinate dehydratase activity
IRJ22_RS00415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IRJ22_RS00420	COG1116	anion transmembrane transporter activity
IRJ22_RS00425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRJ22_RS00430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRJ22_RS00435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRJ22_RS00445	COG1476	TRANSCRIPTIONal
IRJ22_RS00455	COG1131	(ABC) transporter
IRJ22_RS00475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRJ22_RS00485	COG3382	B3 4 domain protein
IRJ22_RS00490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IRJ22_RS00500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IRJ22_RS00505	COG0789	Transcriptional regulator
IRJ22_RS00510	COG1664	Polymer-forming cytoskeletal
IRJ22_RS00520	COG2766	serine protein kinase
IRJ22_RS00525	COG2718	Belongs to the UPF0229 family
IRJ22_RS00535	COG1566	PFAM secretion protein HlyD family protein
IRJ22_RS00540	COG2814	Major facilitator Superfamily
IRJ22_RS00545	COG0655	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS00555	COG1131	(ABC) transporter
IRJ22_RS00560	COG1131	(ABC) transporter
IRJ22_RS00565	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRJ22_RS00570	COG1278	Cold shock
IRJ22_RS00575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IRJ22_RS00580	COG2011	ABC-type metal ion transport system permease component
IRJ22_RS00585	COG1464	Belongs to the NlpA lipoprotein family
IRJ22_RS00590	COG1823	symporter activity
IRJ22_RS00615	COG5577	PFAM Coat F domain
IRJ22_RS00620	COG5002	protein histidine kinase activity
IRJ22_RS00625	COG0737	Belongs to the 5'-nucleotidase family
IRJ22_RS00625	COG1525	nuclease
IRJ22_RS00625	COG4085	toxin activity
IRJ22_RS00630	COG3764	Sortase (surface protein transpeptidase)
IRJ22_RS00635	COG0564	pseudouridine synthase activity
IRJ22_RS00645	COG0517	IMP dehydrogenase activity
IRJ22_RS00650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IRJ22_RS00655	COG3153	acetyltransferase
IRJ22_RS00655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRJ22_RS00660	COG0488	(ABC) transporter
IRJ22_RS00665	COG2116	formate transmembrane transporter activity
IRJ22_RS00670	COG0679	Auxin Efflux Carrier
IRJ22_RS00675	COG0604	alcohol dehydrogenase
IRJ22_RS00680	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IRJ22_RS00685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRJ22_RS00690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IRJ22_RS00695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRJ22_RS00700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRJ22_RS00715	COG4585	Histidine kinase
IRJ22_RS00715	COG2203	Gaf domain
IRJ22_RS00720	COG2197	response regulator
IRJ22_RS00725	COG0431	NADPH-dependent FMN reductase
IRJ22_RS00740	COG1959	2 iron, 2 sulfur cluster binding
IRJ22_RS00745	COG1017	nitric oxide dioxygenase activity
IRJ22_RS00745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IRJ22_RS00750	COG2719	SpoVR family
IRJ22_RS00755	COG0791	NLP P60 protein
IRJ22_RS00755	COG1388	LysM domain
IRJ22_RS00760	COG0583	DNA-binding transcription factor activity
IRJ22_RS00765	COG0372	Belongs to the citrate synthase family
IRJ22_RS00770	COG2133	pyrroloquinoline quinone binding
IRJ22_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS00780	COG0733	neurotransmitter:sodium symporter activity
IRJ22_RS00790	COG3708	Transcriptional regulator
IRJ22_RS00790	COG2207	Transcriptional regulator
IRJ22_RS00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRJ22_RS00815	COG1595	DNA-templated transcription, initiation
IRJ22_RS00820	COG0662	Cupin 2, conserved barrel domain protein
IRJ22_RS00825	COG0204	Acyl-transferase
IRJ22_RS00830	COG3152	Membrane
IRJ22_RS00840	COG1309	transcriptional regulator
IRJ22_RS00845	COG1253	flavin adenine dinucleotide binding
IRJ22_RS00850	COG0789	Transcriptional regulator
IRJ22_RS00855	COG1253	flavin adenine dinucleotide binding
IRJ22_RS00875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRJ22_RS00880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRJ22_RS00885	COG0584	glycerophosphoryl diester phosphodiesterase
IRJ22_RS00895	COG0668	transmembrane transport
IRJ22_RS00900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IRJ22_RS00910	COG0726	polysaccharide deacetylase
IRJ22_RS00920	COG1757	Na H antiporter
IRJ22_RS00925	COG2017	converts alpha-aldose to the beta-anomer
IRJ22_RS00950	COG0589	response to stress
IRJ22_RS00955	COG1132	(ABC) transporter
IRJ22_RS00960	COG1132	(ABC) transporter
IRJ22_RS00965	COG0702	epimerase
IRJ22_RS00985	COG3842	ATPase activity
IRJ22_RS00990	COG2508	Transcriptional regulator
IRJ22_RS01000	COG0189	ligase activity
IRJ22_RS01005	COG0189	ligase activity
IRJ22_RS01010	COG4399	Belongs to the UPF0754 family
IRJ22_RS01015	COG3679	Belongs to the UPF0342 family
IRJ22_RS01020	COG0561	phosphatase activity
IRJ22_RS01025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRJ22_RS01030	COG0475	glutathione-regulated potassium exporter activity
IRJ22_RS01035	COG0490	domain, Protein
IRJ22_RS01045	COG1024	Enoyl-CoA hydratase
IRJ22_RS01050	COG0457	Tetratricopeptide repeat
IRJ22_RS01070	COG4152	abc transporter atp-binding protein
IRJ22_RS01075	COG1668	transmembrane transport
IRJ22_RS01080	COG0420	3'-5' exonuclease activity
IRJ22_RS01085	COG4717	serine-type aminopeptidase activity
IRJ22_RS01090	COG3481	metal-dependent phosphohydrolase, HD sub domain
IRJ22_RS01100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRJ22_RS01130	COG1846	Transcriptional regulator
IRJ22_RS01135	COG4980	gas vesicle protein
IRJ22_RS01150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IRJ22_RS01155	COG0537	adenosine 5'-monophosphoramidase activity
IRJ22_RS01160	COG1131	(ABC) transporter
IRJ22_RS01165	COG4473	ABC transporter
IRJ22_RS01175	COG1473	amidohydrolase
IRJ22_RS01180	COG3069	C4-dicarboxylate transmembrane transporter activity
IRJ22_RS01185	COG2329	Antibiotic biosynthesis monooxygenase
IRJ22_RS01190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRJ22_RS01195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRJ22_RS01200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IRJ22_RS01205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IRJ22_RS01210	COG1309	transcriptional regulator
IRJ22_RS01215	COG1511	domain protein
IRJ22_RS01220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRJ22_RS01225	COG1363	Peptidase, m42
IRJ22_RS01235	COG1301	dicarboxylic acid transport
IRJ22_RS01245	COG1234	tRNA 3'-trailer cleavage
IRJ22_RS01250	COG0095	Lipoate-protein ligase
IRJ22_RS01255	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS01265	COG1396	sequence-specific DNA binding
IRJ22_RS01280	COG0501	Belongs to the peptidase M48B family
IRJ22_RS01290	COG0697	spore germination
IRJ22_RS01295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IRJ22_RS01300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS01305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS01310	COG0406	alpha-ribazole phosphatase activity
IRJ22_RS01315	COG0840	transmembrane signaling receptor activity
IRJ22_RS01320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRJ22_RS01320	COG0723	plastoquinol--plastocyanin reductase activity
IRJ22_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS01335	COG4903	ComK protein
IRJ22_RS01345	COG0398	Pfam SNARE associated Golgi protein
IRJ22_RS01350	COG0681	Belongs to the peptidase S26 family
IRJ22_RS01355	COG1404	Belongs to the peptidase S8 family
IRJ22_RS01365	COG2508	Transcriptional regulator
IRJ22_RS01370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRJ22_RS01375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRJ22_RS01380	COG3257	ureidoglycine aminohydrolase activity
IRJ22_RS01385	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IRJ22_RS01390	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IRJ22_RS01395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRJ22_RS01400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRJ22_RS01410	COG0549	Belongs to the carbamate kinase family
IRJ22_RS01415	COG2814	Major facilitator Superfamily
IRJ22_RS01425	COG0457	Tetratricopeptide repeat
IRJ22_RS01445	COG1609	Transcriptional regulator
IRJ22_RS01450	COG1653	transport
IRJ22_RS01455	COG1175	transmembrane transport
IRJ22_RS01460	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS01465	COG1486	melibiose metabolic process
IRJ22_RS01470	COG3180	Ammonia monooxygenase
IRJ22_RS01485	COG3546	catalase activity
IRJ22_RS01490	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS01495	COG0477	Major facilitator Superfamily
IRJ22_RS01495	COG2814	Major facilitator Superfamily
IRJ22_RS01505	COG5002	protein histidine kinase activity
IRJ22_RS01510	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS01515	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IRJ22_RS01520	COG0725	ABC transporter, periplasmic molybdate-binding protein
IRJ22_RS01525	COG4149	molybdate abc transporter
IRJ22_RS01530	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IRJ22_RS01535	COG1074	ATP-dependent DNA helicase activity
IRJ22_RS01540	COG0420	3'-5' exonuclease activity
IRJ22_RS01545	COG0419	ATPase involved in DNA repair
IRJ22_RS01590	COG5337	Spore coat protein CotH
IRJ22_RS01600	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRJ22_RS01620	COG0367	asparagine synthase
IRJ22_RS01625	COG0004	ammonium transporteR
IRJ22_RS01635	COG0534	Mate efflux family protein
IRJ22_RS01640	COG2207	Transcriptional regulator
IRJ22_RS01640	COG1917	Cupin 2, conserved barrel domain protein
IRJ22_RS01650	COG1609	Transcriptional regulator
IRJ22_RS01655	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS01670	COG0076	glutamate decarboxylase activity
IRJ22_RS01695	COG2153	protein acetylation
IRJ22_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS01705	COG2378	regulation of single-species biofilm formation
IRJ22_RS01710	COG0646	methionine synthase
IRJ22_RS01710	COG1410	methionine synthase
IRJ22_RS01715	COG0646	methionine synthase
IRJ22_RS01715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRJ22_RS01720	COG1666	GTP binding
IRJ22_RS01725	COG2996	Protein conserved in bacteria
IRJ22_RS01740	COG1307	EDD domain protein, DegV family
IRJ22_RS01745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS01755	COG0516	GMP reductase activity
IRJ22_RS01770	COG0561	phosphatase activity
IRJ22_RS01775	COG1073	alpha beta
IRJ22_RS01780	COG2151	metal-sulfur cluster biosynthetic enzyme
IRJ22_RS01785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IRJ22_RS01790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IRJ22_RS01795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IRJ22_RS01800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRJ22_RS01805	COG0505	Belongs to the CarA family
IRJ22_RS01810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRJ22_RS01815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IRJ22_RS01820	COG1968	undecaprenyl-diphosphatase activity
IRJ22_RS01835	COG2267	carboxylic ester hydrolase activity
IRJ22_RS01845	COG1744	ABC transporter substrate-binding protein PnrA-like
IRJ22_RS01860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRJ22_RS01865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IRJ22_RS01870	COG5504	Zn-dependent protease
IRJ22_RS01875	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS01880	COG4608	Belongs to the ABC transporter superfamily
IRJ22_RS01890	COG0601	transmembrane transport
IRJ22_RS01895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS01910	COG0180	Tryptophanyl-tRNA synthetase
IRJ22_RS01915	COG4166	transmembrane transport
IRJ22_RS01920	COG0601	transmembrane transport
IRJ22_RS01925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS01930	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS01935	COG4608	Belongs to the ABC transporter superfamily
IRJ22_RS01940	COG0456	acetyltransferase
IRJ22_RS01945	COG1393	Belongs to the ArsC family
IRJ22_RS01950	COG0861	Integral membrane protein TerC family
IRJ22_RS01960	COG4862	establishment of competence for transformation
IRJ22_RS01980	COG4565	transcriptional regulatory protein
IRJ22_RS01985	COG3290	protein histidine kinase activity
IRJ22_RS01990	COG3290	protein histidine kinase activity
IRJ22_RS01995	COG4469	Competence protein
IRJ22_RS02000	COG1164	Oligoendopeptidase f
IRJ22_RS02010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IRJ22_RS02015	COG2346	COG2346, Truncated hemoglobins
IRJ22_RS02020	COG0741	lytic transglycosylase activity
IRJ22_RS02025	COG4116	CYTH
IRJ22_RS02035	COG2357	RelA SpoT domain protein
IRJ22_RS02040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRJ22_RS02045	COG0564	pseudouridine synthase activity
IRJ22_RS02050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRJ22_RS02055	COG0475	glutathione-regulated potassium exporter activity
IRJ22_RS02055	COG0569	domain protein
IRJ22_RS02060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRJ22_RS02065	COG0352	thiamine-phosphate diphosphorylase activity
IRJ22_RS02075	COG2104	thiamine diphosphate biosynthetic process
IRJ22_RS02080	COG2022	thiamine diphosphate biosynthetic process
IRJ22_RS02085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IRJ22_RS02090	COG0351	phosphomethylpyrimidine kinase
IRJ22_RS02095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IRJ22_RS02150	COG0210	DNA helicase
IRJ22_RS02160	COG0586	Pfam SNARE associated Golgi protein
IRJ22_RS02165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRJ22_RS02170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRJ22_RS02175	COG2246	polysaccharide biosynthetic process
IRJ22_RS02180	COG2153	protein acetylation
IRJ22_RS02185	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRJ22_RS02190	COG2382	esterase
IRJ22_RS02205	COG0626	cystathionine gamma-synthase activity
IRJ22_RS02210	COG0626	cystathionine gamma-synthase activity
IRJ22_RS02215	COG5505	Protein of unknown function (DUF819)
IRJ22_RS02230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRJ22_RS02235	COG3507	Belongs to the glycosyl hydrolase 43 family
IRJ22_RS02255	COG0110	maltose O-acetyltransferase activity
IRJ22_RS02265	COG0583	DNA-binding transcription factor activity
IRJ22_RS02270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IRJ22_RS02275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRJ22_RS02280	COG0583	DNA-binding transcription factor activity
IRJ22_RS02285	COG0697	spore germination
IRJ22_RS02290	COG0346	lactoylglutathione lyase activity
IRJ22_RS02300	COG3584	3D domain protein
IRJ22_RS02300	COG1388	LysM domain
IRJ22_RS02305	COG2814	Major facilitator Superfamily
IRJ22_RS02310	COG1309	transcriptional regulator
IRJ22_RS02330	COG5444	nuclease activity
IRJ22_RS02335	COG4195	phage-related replication protein
IRJ22_RS02340	COG2856	Zn peptidase
IRJ22_RS02345	COG1396	sequence-specific DNA binding
IRJ22_RS02360	COG1522	sequence-specific DNA binding
IRJ22_RS02365	COG1484	DNA-dependent DNA replication
IRJ22_RS02385	COG1595	DNA-templated transcription, initiation
IRJ22_RS02390	COG5484	DNA packaging
IRJ22_RS02390	COG3728	DNA packaging
IRJ22_RS02395	COG1783	phage Terminase large subunit
IRJ22_RS02400	COG5518	Phage portal protein
IRJ22_RS02405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IRJ22_RS02410	COG4653	Phage capsid family
IRJ22_RS02460	COG3953	SLT domain
IRJ22_RS02460	COG5412	phage tail tape measure protein
IRJ22_RS02465	COG1652	LysM domain
IRJ22_RS02470	COG4193	domain, Protein
IRJ22_RS02480	COG3628	GPW Gp25 family protein
IRJ22_RS02485	COG3299	homolog of phage Mu protein gp47
IRJ22_RS02490	COG3778	Protein conserved in bacteria
IRJ22_RS02525	COG1802	Transcriptional regulator
IRJ22_RS02530	COG1063	alcohol dehydrogenase
IRJ22_RS02535	COG1312	Catalyzes the dehydration of D-mannonate
IRJ22_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS02545	COG1063	alcohol dehydrogenase
IRJ22_RS02550	COG2271	Major facilitator Superfamily
IRJ22_RS02570	COG0306	phosphate transporter
IRJ22_RS02575	COG1392	Phosphate transport regulator
IRJ22_RS02580	COG0405	Gamma-glutamyltransferase
IRJ22_RS02585	COG5578	integral membrane protein
IRJ22_RS02590	COG2972	Histidine kinase
IRJ22_RS02595	COG4753	response regulator
IRJ22_RS02595	COG2207	Transcriptional regulator
IRJ22_RS02600	COG1653	transport
IRJ22_RS02605	COG1175	transmembrane transport
IRJ22_RS02610	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS02615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IRJ22_RS02620	COG2207	Transcriptional regulator
IRJ22_RS02625	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS02635	COG5578	integral membrane protein
IRJ22_RS02640	COG3401	FG-GAP repeat protein
IRJ22_RS02655	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS02660	COG3401	FG-GAP repeat protein
IRJ22_RS02665	COG0667	Aldo Keto reductase
IRJ22_RS02670	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS02675	COG1874	Beta-galactosidase
IRJ22_RS02685	COG1653	transport
IRJ22_RS02690	COG4209	transmembrane transport
IRJ22_RS02695	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS02700	COG0531	amino acid
IRJ22_RS02705	COG0346	lactoylglutathione lyase activity
IRJ22_RS02715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRJ22_RS02720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRJ22_RS02725	COG2362	D-Aminopeptidase
IRJ22_RS02730	COG0601	transmembrane transport
IRJ22_RS02735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS02740	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS02745	COG4166	transmembrane transport
IRJ22_RS02750	COG1619	proteins homologs of microcin C7 resistance protein MccF
IRJ22_RS02755	COG4948	Mandelate Racemase Muconate Lactonizing
IRJ22_RS02760	COG0791	NLP P60 protein
IRJ22_RS02765	COG4608	Belongs to the ABC transporter superfamily
IRJ22_RS02770	COG1834	amidinotransferase
IRJ22_RS02775	COG1607	acyl-coa hydrolase
IRJ22_RS02780	COG2323	membrane
IRJ22_RS02785	COG3866	Pectate lyase
IRJ22_RS02805	COG2318	DinB family
IRJ22_RS02810	COG2076	Multidrug Resistance protein
IRJ22_RS02815	COG2076	Multidrug Resistance protein
IRJ22_RS02820	COG0788	formyltetrahydrofolate deformylase activity
IRJ22_RS02825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IRJ22_RS02830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IRJ22_RS02835	COG1764	response to oxidative stress
IRJ22_RS02840	COG1846	Transcriptional regulator
IRJ22_RS02845	COG1764	response to oxidative stress
IRJ22_RS02855	COG0590	tRNA wobble adenosine to inosine editing
IRJ22_RS02860	COG0406	alpha-ribazole phosphatase activity
IRJ22_RS02875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IRJ22_RS02880	COG1404	Belongs to the peptidase S8 family
IRJ22_RS02890	COG2239	Acts as a magnesium transporter
IRJ22_RS02900	COG0789	Transcriptional regulator
IRJ22_RS02915	COG1846	Transcriptional regulator
IRJ22_RS02920	COG3285	dna ligase
IRJ22_RS02920	COG1793	dna ligase
IRJ22_RS02925	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IRJ22_RS02930	COG3300	MHYT domain
IRJ22_RS02930	COG5001	Diguanylate cyclase
IRJ22_RS02935	COG0586	Pfam SNARE associated Golgi protein
IRJ22_RS02945	COG1191	sigma factor activity
IRJ22_RS02965	COG0501	Belongs to the peptidase M48B family
IRJ22_RS02970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IRJ22_RS02975	COG0768	penicillin binding
IRJ22_RS02990	COG3594	Acyltransferase
IRJ22_RS02995	COG5002	protein histidine kinase activity
IRJ22_RS03000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRJ22_RS03010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IRJ22_RS03015	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IRJ22_RS03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRJ22_RS03025	COG0436	Aminotransferase
IRJ22_RS03030	COG1850	ribulose-bisphosphate carboxylase activity
IRJ22_RS03040	COG0235	Class ii aldolase
IRJ22_RS03040	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IRJ22_RS03045	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IRJ22_RS03050	COG0346	lactoylglutathione lyase activity
IRJ22_RS03055	COG3339	Conserved Protein
IRJ22_RS03065	COG3852	Histidine kinase
IRJ22_RS03070	COG1846	Transcriptional regulator
IRJ22_RS03075	COG1360	Flagellar Motor Protein
IRJ22_RS03080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRJ22_RS03085	COG0542	response to heat
IRJ22_RS03090	COG3949	Membrane
IRJ22_RS03095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IRJ22_RS03100	COG0720	synthase
IRJ22_RS03105	COG0602	queuosine metabolic process
IRJ22_RS03110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IRJ22_RS03120	COG3739	integral membrane protein
IRJ22_RS03125	COG3655	Transcriptional regulator
IRJ22_RS03160	COG4873	Protein conserved in bacteria
IRJ22_RS03170	COG3773	Cell wall hydrolase
IRJ22_RS03175	COG2244	polysaccharide biosynthetic process
IRJ22_RS03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS03185	COG2217	Heavy metal translocating P-type atpase
IRJ22_RS03190	COG0006	proline dipeptidase activity
IRJ22_RS03200	COG1609	Transcriptional regulator
IRJ22_RS03205	COG3711	transcriptional antiterminator
IRJ22_RS03210	COG1263	PTS System
IRJ22_RS03210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS03210	COG2190	(PTS) system
IRJ22_RS03215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS03220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IRJ22_RS03230	COG1533	DNA photolyase activity
IRJ22_RS03235	COG0456	acetyltransferase
IRJ22_RS03240	COG0840	transmembrane signaling receptor activity
IRJ22_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS03250	COG2084	Dehydrogenase
IRJ22_RS03255	COG2340	Cysteine-rich secretory protein family
IRJ22_RS03260	COG0768	penicillin binding
IRJ22_RS03265	COG4191	Histidine kinase
IRJ22_RS03270	COG0436	Aminotransferase
IRJ22_RS03280	COG1714	RDD family
IRJ22_RS03290	COG0784	Response regulator, receiver
IRJ22_RS03290	COG0835	chemotaxis
IRJ22_RS03300	COG2814	Major facilitator Superfamily
IRJ22_RS03305	COG1376	ErfK ybiS ycfS ynhG family protein
IRJ22_RS03310	COG1408	metallophosphoesterase
IRJ22_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS03320	COG2200	EAL domain
IRJ22_RS03330	COG4703	Protein of unknown function (DUF1797)
IRJ22_RS03340	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IRJ22_RS03350	COG0517	IMP dehydrogenase activity
IRJ22_RS03355	COG0583	DNA-binding transcription factor activity
IRJ22_RS03360	COG0716	FMN binding
IRJ22_RS03370	COG0716	FMN binding
IRJ22_RS03375	COG2171	N-acyltransferase activity
IRJ22_RS03380	COG1473	amidohydrolase
IRJ22_RS03390	COG0450	alkyl hydroperoxide reductase
IRJ22_RS03395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS03410	COG0746	molybdenum cofactor guanylyltransferase activity
IRJ22_RS03415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IRJ22_RS03420	COG0303	'Molybdopterin
IRJ22_RS03425	COG1763	Mo-molybdopterin cofactor biosynthetic process
IRJ22_RS03430	COG0314	molybdopterin synthase activity
IRJ22_RS03435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IRJ22_RS03445	COG1132	(ABC) transporter
IRJ22_RS03450	COG1132	(ABC) transporter
IRJ22_RS03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRJ22_RS03465	COG1136	(ABC) transporter
IRJ22_RS03470	COG0577	efflux transmembrane transporter activity
IRJ22_RS03475	COG1349	DNA-binding transcription factor activity
IRJ22_RS03480	COG1105	Belongs to the carbohydrate kinase PfkB family
IRJ22_RS03485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS03485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS03485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS03505	COG0488	(ABC) transporter
IRJ22_RS03515	COG2309	aminopeptidase activity
IRJ22_RS03525	COG1077	Cell shape determining protein MreB Mrl
IRJ22_RS03530	COG2002	toxin-antitoxin pair type II binding
IRJ22_RS03535	COG3852	Histidine kinase
IRJ22_RS03540	COG0569	domain protein
IRJ22_RS03545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRJ22_RS03550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRJ22_RS03555	COG5503	Protein of unknown function (DUF1447)
IRJ22_RS03560	COG0561	phosphatase activity
IRJ22_RS03565	COG0242	peptide deformylase activity
IRJ22_RS03575	COG0497	DNA recombination
IRJ22_RS03580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRJ22_RS03585	COG0022	dehydrogenase e1 component
IRJ22_RS03590	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRJ22_RS03595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRJ22_RS03600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS03610	COG1982	Orn Lys Arg decarboxylase major
IRJ22_RS03615	COG4476	Belongs to the UPF0223 family
IRJ22_RS03620	COG4493	Belongs to the UPF0637 family
IRJ22_RS03630	COG0483	inositol monophosphate 1-phosphatase activity
IRJ22_RS03650	COG1595	DNA-templated transcription, initiation
IRJ22_RS03665	COG1217	gtp-binding protein TYPA
IRJ22_RS03675	COG1846	Transcriptional regulator
IRJ22_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IRJ22_RS03685	COG4896	Protein conserved in bacteria
IRJ22_RS03695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IRJ22_RS03700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRJ22_RS03705	COG2066	Belongs to the glutaminase family
IRJ22_RS03710	COG4838	Belongs to the UPF0358 family
IRJ22_RS03715	COG0772	Belongs to the SEDS family
IRJ22_RS03720	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IRJ22_RS03725	COG1612	heme a metabolic process
IRJ22_RS03730	COG0109	protoheme IX farnesyltransferase activity
IRJ22_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRJ22_RS03735	COG2010	Cytochrome c
IRJ22_RS03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRJ22_RS03745	COG1845	cytochrome c oxidase, subunit III
IRJ22_RS03750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IRJ22_RS03755	COG3336	cytochrome c oxidase
IRJ22_RS03765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IRJ22_RS03770	COG2340	Cysteine-rich secretory protein family
IRJ22_RS03785	COG3679	Belongs to the UPF0342 family
IRJ22_RS03790	COG4471	UPF0298 protein
IRJ22_RS03795	COG0742	ribosomal rna small subunit methyltransferase
IRJ22_RS03800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IRJ22_RS03805	COG3314	Sporulation integral membrane protein YlbJ
IRJ22_RS03810	COG3480	Lon protease (S16) C-terminal proteolytic domain
IRJ22_RS03815	COG1323	Belongs to the UPF0348 family
IRJ22_RS03820	COG1399	metal-binding, possibly nucleic acid-binding protein
IRJ22_RS03825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IRJ22_RS03835	COG0454	-acetyltransferase
IRJ22_RS03840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRJ22_RS03845	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IRJ22_RS03850	COG2001	Belongs to the MraZ family
IRJ22_RS03855	COG0275	rRNA processing
IRJ22_RS03860	COG4839	cell division protein FtsL
IRJ22_RS03865	COG0768	penicillin binding
IRJ22_RS03870	COG0768	penicillin binding
IRJ22_RS03875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IRJ22_RS03880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRJ22_RS03885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IRJ22_RS03890	COG0772	Belongs to the SEDS family
IRJ22_RS03895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRJ22_RS03900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IRJ22_RS03905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IRJ22_RS03910	COG3879	Bacterial protein of unknown function (DUF881)
IRJ22_RS03915	COG3879	Bacterial protein of unknown function (DUF881)
IRJ22_RS03920	COG3856	small basic protein
IRJ22_RS03925	COG0849	cell division
IRJ22_RS03930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IRJ22_RS03940	COG4412	M6 family metalloprotease domain protein
IRJ22_RS03940	COG1404	Belongs to the peptidase S8 family
IRJ22_RS03950	COG1191	sigma factor activity
IRJ22_RS03955	COG1191	sigma factor activity
IRJ22_RS03960	COG1119	ATPase activity
IRJ22_RS03965	COG0500	methyltransferase
IRJ22_RS03970	COG1873	PFAM PRC-barrel domain
IRJ22_RS03975	COG1496	oxidoreductase activity
IRJ22_RS03980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IRJ22_RS03985	COG1799	cell septum assembly
IRJ22_RS03990	COG0762	integral membrane protein
IRJ22_RS03995	COG2302	S4 RNA-binding domain
IRJ22_RS04000	COG3599	regulation of cell shape
IRJ22_RS04005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IRJ22_RS04010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRJ22_RS04015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IRJ22_RS04020	COG0564	pseudouridine synthase activity
IRJ22_RS04025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IRJ22_RS04030	COG2233	PERMEase
IRJ22_RS04035	COG0540	Belongs to the ATCase OTCase family
IRJ22_RS04040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRJ22_RS04045	COG0505	Belongs to the CarA family
IRJ22_RS04050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRJ22_RS04055	COG0543	2 iron, 2 sulfur cluster binding
IRJ22_RS04060	COG0167	dihydroorotate dehydrogenase activity
IRJ22_RS04065	COG0284	orotidine-5'-phosphate decarboxylase activity
IRJ22_RS04070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IRJ22_RS04080	COG0175	sulfate reduction
IRJ22_RS04085	COG0306	phosphate transporter
IRJ22_RS04090	COG2046	Belongs to the sulfate adenylyltransferase family
IRJ22_RS04095	COG0529	Catalyzes the synthesis of activated sulfate
IRJ22_RS04100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRJ22_RS04105	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IRJ22_RS04110	COG1648	precorrin-2 dehydrogenase activity
IRJ22_RS04120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRJ22_RS04125	COG1561	YicC-like family, N-terminal region
IRJ22_RS04130	COG2052	Domain of unknown function (DUF370)
IRJ22_RS04135	COG0194	GDP metabolic process
IRJ22_RS04140	COG1758	RNA polymerase activity
IRJ22_RS04145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRJ22_RS04150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRJ22_RS04155	COG0242	peptide deformylase activity
IRJ22_RS04160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IRJ22_RS04165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRJ22_RS04165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRJ22_RS04170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IRJ22_RS04175	COG0631	protein serine/threonine phosphatase activity
IRJ22_RS04180	COG0515	serine threonine protein kinase
IRJ22_RS04180	COG2815	serine threonine protein kinase
IRJ22_RS04185	COG1162	GTPase activity
IRJ22_RS04190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRJ22_RS04195	COG1564	THIamine pyrophosphokinase
IRJ22_RS04205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IRJ22_RS04210	COG1302	Protein conserved in bacteria
IRJ22_RS04215	COG1461	Dihydroxyacetone kinase
IRJ22_RS04220	COG1760	l-serine dehydratase
IRJ22_RS04225	COG1760	l-serine dehydratase
IRJ22_RS04230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IRJ22_RS04235	COG1349	DNA-binding transcription factor activity
IRJ22_RS04240	COG0416	fatty acid biosynthetic process
IRJ22_RS04245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IRJ22_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS04255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRJ22_RS04260	COG0571	ribonuclease III activity
IRJ22_RS04265	COG1196	nuclear chromosome segregation
IRJ22_RS04270	COG0552	protein localization to endoplasmic reticulum
IRJ22_RS04275	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IRJ22_RS04280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IRJ22_RS04285	COG0228	four-way junction DNA binding
IRJ22_RS04290	COG1837	Belongs to the UPF0109 family
IRJ22_RS04300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IRJ22_RS04305	COG0336	Belongs to the RNA methyltransferase TrmD family
IRJ22_RS04310	COG0335	large ribosomal subunit rRNA binding
IRJ22_RS04315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRJ22_RS04320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IRJ22_RS04330	COG2257	FlhB HrpN YscU SpaS Family
IRJ22_RS04335	COG0045	succinate-CoA ligase (ADP-forming) activity
IRJ22_RS04340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRJ22_RS04345	COG0758	DNA mediated transformation
IRJ22_RS04350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRJ22_RS04355	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IRJ22_RS04360	COG4974	Belongs to the 'phage' integrase family
IRJ22_RS04365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IRJ22_RS04370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IRJ22_RS04375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRJ22_RS04380	COG1815	bacterial-type flagellum-dependent cell motility
IRJ22_RS04385	COG1558	bacterial-type flagellum-dependent cell motility
IRJ22_RS04390	COG1677	Flagellar hook-basal body complex protein FliE
IRJ22_RS04395	COG1766	The M ring may be actively involved in energy transduction
IRJ22_RS04400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRJ22_RS04405	COG1317	bacterial-type flagellum organization
IRJ22_RS04410	COG1157	protein secretion by the type III secretion system
IRJ22_RS04415	COG2882	bacterial-type flagellum organization
IRJ22_RS04425	COG3144	bacterial-type flagellum assembly
IRJ22_RS04430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IRJ22_RS04435	COG4786	Flagellar basal body rod
IRJ22_RS04440	COG1582	Flagellar protein (FlbD)
IRJ22_RS04445	COG1580	Controls the rotational direction of flagella during chemotaxis
IRJ22_RS04450	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRJ22_RS04455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRJ22_RS04455	COG1776	CheC inhibitor of MCP methylation
IRJ22_RS04460	COG2201	protein-glutamate methylesterase activity
IRJ22_RS04465	COG3190	flagellar
IRJ22_RS04470	COG1338	Plays a role in the flagellum-specific transport system
IRJ22_RS04475	COG1987	bacterial-type flagellum assembly
IRJ22_RS04480	COG1684	flagellar biosynthetic protein fliR
IRJ22_RS04485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRJ22_RS04490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRJ22_RS04495	COG1419	protein localization to endoplasmic reticulum
IRJ22_RS04500	COG0455	bacterial-type flagellum organization
IRJ22_RS04505	COG2201	protein-glutamate methylesterase activity
IRJ22_RS04510	COG0643	Histidine kinase
IRJ22_RS04510	COG2198	Histidine kinase
IRJ22_RS04515	COG0835	chemotaxis
IRJ22_RS04520	COG1776	CheC inhibitor of MCP methylation
IRJ22_RS04525	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IRJ22_RS04540	COG0052	Belongs to the universal ribosomal protein uS2 family
IRJ22_RS04545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IRJ22_RS04550	COG0528	UMP kinase activity
IRJ22_RS04555	COG0233	cytoplasmic translational termination
IRJ22_RS04560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IRJ22_RS04565	COG4589	Belongs to the CDS family
IRJ22_RS04570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IRJ22_RS04575	COG0750	zinc metalloprotease
IRJ22_RS04580	COG0442	prolyl-tRNA aminoacylation
IRJ22_RS04585	COG2176	DNA-directed DNA polymerase activity
IRJ22_RS04610	COG0779	Required for maturation of 30S ribosomal subunits
IRJ22_RS04615	COG0195	Participates in both transcription termination and antitermination
IRJ22_RS04620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IRJ22_RS04625	COG1358	cellular component organization or biogenesis
IRJ22_RS04630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IRJ22_RS04635	COG1550	Protein conserved in bacteria
IRJ22_RS04640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IRJ22_RS04645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IRJ22_RS04650	COG0196	riboflavin kinase activity
IRJ22_RS04655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IRJ22_RS04660	COG1185	polyribonucleotide nucleotidyltransferase activity
IRJ22_RS04665	COG0726	polysaccharide deacetylase
IRJ22_RS04670	COG0612	Peptidase, M16
IRJ22_RS04675	COG1873	PFAM PRC-barrel domain
IRJ22_RS04680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRJ22_RS04685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRJ22_RS04690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IRJ22_RS04695	COG0527	aspartate kinase activity
IRJ22_RS04705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRJ22_RS04710	COG0740	serine-type endopeptidase activity
IRJ22_RS04720	COG1674	ftsk spoiiie
IRJ22_RS04720	COG4980	gas vesicle protein
IRJ22_RS04725	COG2188	Transcriptional regulator
IRJ22_RS04730	COG2814	Major facilitator Superfamily
IRJ22_RS04735	COG0612	Peptidase, M16
IRJ22_RS04740	COG0612	Peptidase, M16
IRJ22_RS04745	COG0300	oxidoreductase activity
IRJ22_RS04760	COG1426	Protein conserved in bacteria
IRJ22_RS04765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRJ22_RS04770	COG1546	Belongs to the CinA family
IRJ22_RS04770	COG1058	Belongs to the CinA family
IRJ22_RS04780	COG1418	mRNA catabolic process
IRJ22_RS04785	COG1692	metallophosphoesterase
IRJ22_RS04790	COG2359	stage V sporulation protein S
IRJ22_RS04800	COG1063	alcohol dehydrogenase
IRJ22_RS04805	COG0156	8-amino-7-oxononanoate synthase activity
IRJ22_RS04810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRJ22_RS04815	COG4550	Control of competence regulator ComK, YlbF/YmcA
IRJ22_RS04825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRJ22_RS04830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IRJ22_RS04835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IRJ22_RS04840	COG5444	nuclease activity
IRJ22_RS04855	COG0523	cobalamin synthesis protein
IRJ22_RS04865	COG1247	-acetyltransferase
IRJ22_RS04885	COG3619	membrane
IRJ22_RS04890	COG3263	regulation of cellular component size
IRJ22_RS04895	COG2814	Major facilitator Superfamily
IRJ22_RS04900	COG2814	Major facilitator Superfamily
IRJ22_RS04910	COG0393	Putative heavy-metal-binding
IRJ22_RS04915	COG0398	Pfam SNARE associated Golgi protein
IRJ22_RS04920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRJ22_RS04925	COG1819	glycosyl
IRJ22_RS04930	COG0531	amino acid
IRJ22_RS04935	COG5577	PFAM Coat F domain
IRJ22_RS04945	COG1388	LysM domain
IRJ22_RS04945	COG3858	chitin binding
IRJ22_RS04950	COG1309	transcriptional regulator
IRJ22_RS04955	COG3631	Ketosteroid isomerase-related protein
IRJ22_RS04960	COG0702	epimerase
IRJ22_RS04970	COG1764	response to oxidative stress
IRJ22_RS04975	COG2076	Multidrug Resistance protein
IRJ22_RS04980	COG2076	Multidrug Resistance protein
IRJ22_RS04995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IRJ22_RS05000	COG1923	regulation of RNA biosynthetic process
IRJ22_RS05010	COG1780	Probably involved in ribonucleotide reductase function
IRJ22_RS05015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRJ22_RS05020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRJ22_RS05025	COG4112	unkown
IRJ22_RS05040	COG0735	belongs to the Fur family
IRJ22_RS05045	COG1802	Transcriptional regulator
IRJ22_RS05050	COG0697	spore germination
IRJ22_RS05085	COG1309	transcriptional regulator
IRJ22_RS05130	COG0464	growth
IRJ22_RS05135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IRJ22_RS05140	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IRJ22_RS05145	COG0789	Transcriptional regulator
IRJ22_RS05150	COG0174	glutamine synthetase
IRJ22_RS05185	COG1073	alpha beta
IRJ22_RS05230	COG1309	transcriptional regulator
IRJ22_RS05235	COG2076	Multidrug Resistance protein
IRJ22_RS05240	COG2076	Multidrug Resistance protein
IRJ22_RS05265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS05270	COG3546	catalase activity
IRJ22_RS05295	COG1846	Transcriptional regulator
IRJ22_RS05300	COG0778	Nitroreductase
IRJ22_RS05305	COG0346	lactoylglutathione lyase activity
IRJ22_RS05310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IRJ22_RS05315	COG0655	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS05340	COG3209	COG3209 Rhs family protein
IRJ22_RS05345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRJ22_RS05350	COG1388	LysM domain
IRJ22_RS05355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRJ22_RS05360	COG4224	UPF0291 protein
IRJ22_RS05365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IRJ22_RS05375	COG3763	UPF0154 protein
IRJ22_RS05385	COG0785	Cytochrome C biogenesis protein
IRJ22_RS05390	COG2201	protein-glutamate methylesterase activity
IRJ22_RS05395	COG4846	Membrane protein involved in cytochrome C biogenesis
IRJ22_RS05405	COG0071	Belongs to the small heat shock protein (HSP20) family
IRJ22_RS05420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IRJ22_RS05425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS05445	COG0824	Thioesterase
IRJ22_RS05470	COG4841	protein insertion into membrane
IRJ22_RS05475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IRJ22_RS05480	COG1832	CoA-binding protein
IRJ22_RS05485	COG0187	DNA topoisomerase II activity
IRJ22_RS05490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRJ22_RS05495	COG1609	Transcriptional regulator
IRJ22_RS05510	COG2160	L-arabinose isomerase activity
IRJ22_RS05530	COG1115	amino acid carrier protein
IRJ22_RS05540	COG2181	nitrate reductase activity
IRJ22_RS05545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IRJ22_RS05550	COG1140	nitrate reductase beta subunit
IRJ22_RS05555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IRJ22_RS05570	COG0535	radical SAM domain protein
IRJ22_RS05575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRJ22_RS05585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRJ22_RS05590	COG2223	nitrite transmembrane transporter activity
IRJ22_RS05610	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IRJ22_RS05620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IRJ22_RS05630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRJ22_RS05640	COG0492	ferredoxin-NADP+ reductase activity
IRJ22_RS05655	COG3420	alginic acid biosynthetic process
IRJ22_RS05660	COG1114	Component of the transport system for branched-chain amino acids
IRJ22_RS05665	COG1064	alcohol dehydrogenase
IRJ22_RS05670	COG0789	Transcriptional regulator
IRJ22_RS05695	COG1024	Enoyl-CoA hydratase
IRJ22_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS05705	COG2084	Dehydrogenase
IRJ22_RS05710	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS05715	COG1482	cell wall glycoprotein biosynthetic process
IRJ22_RS05720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS05720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS05720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS05740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS05740	COG3711	transcriptional antiterminator
IRJ22_RS05755	COG1725	Transcriptional regulator
IRJ22_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS05765	COG1312	Catalyzes the dehydration of D-mannonate
IRJ22_RS05780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IRJ22_RS05790	COG1609	Transcriptional regulator
IRJ22_RS05795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRJ22_RS05800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IRJ22_RS05805	COG0640	Transcriptional regulator
IRJ22_RS05810	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IRJ22_RS05830	COG2404	hydrolase activity, acting on ester bonds
IRJ22_RS05835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IRJ22_RS05845	COG2027	D-alanyl-D-alanine carboxypeptidase
IRJ22_RS05850	COG1252	NADH dehydrogenase
IRJ22_RS05860	COG0166	Belongs to the GPI family
IRJ22_RS05870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRJ22_RS05875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRJ22_RS05880	COG1024	Enoyl-CoA hydratase
IRJ22_RS05885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRJ22_RS05890	COG0511	ligase activity, forming carbon-carbon bonds
IRJ22_RS05895	COG0439	Biotin carboxylase
IRJ22_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS05905	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS05910	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS05915	COG1733	regulation of RNA biosynthetic process
IRJ22_RS05920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IRJ22_RS05925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IRJ22_RS05935	COG2323	membrane
IRJ22_RS05945	COG0306	phosphate transporter
IRJ22_RS05950	COG0175	sulfate reduction
IRJ22_RS05955	COG1809	phosphosulfolactate synthase activity
IRJ22_RS05960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS05965	COG4948	Mandelate Racemase Muconate Lactonizing
IRJ22_RS05970	COG2814	Major facilitator Superfamily
IRJ22_RS05975	COG0463	Glycosyl transferase, family 2
IRJ22_RS05985	COG0493	'glutamate synthase
IRJ22_RS05990	COG0070	glutamate synthase
IRJ22_RS05990	COG0069	glutamate synthase activity
IRJ22_RS05990	COG0067	glutamate synthase
IRJ22_RS05995	COG0583	DNA-binding transcription factor activity
IRJ22_RS06015	COG1846	Transcriptional regulator
IRJ22_RS06025	COG1132	(ABC) transporter
IRJ22_RS06035	COG0300	oxidoreductase activity
IRJ22_RS06040	COG0574	Belongs to the PEP-utilizing enzyme family
IRJ22_RS06040	COG3848	Pyruvate phosphate dikinase
IRJ22_RS06050	COG0477	Major facilitator Superfamily
IRJ22_RS06055	COG0243	molybdopterin cofactor binding
IRJ22_RS06060	COG1846	Transcriptional regulator
IRJ22_RS06070	COG0531	amino acid
IRJ22_RS06080	COG0531	amino acid
IRJ22_RS06085	COG0531	amino acid
IRJ22_RS06090	COG0697	spore germination
IRJ22_RS06095	COG0488	(ABC) transporter
IRJ22_RS06100	COG0840	transmembrane signaling receptor activity
IRJ22_RS06105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRJ22_RS06110	COG1404	Belongs to the peptidase S8 family
IRJ22_RS06120	COG1309	transcriptional regulator
IRJ22_RS06125	COG1846	Transcriptional regulator
IRJ22_RS06155	COG1309	transcriptional regulator
IRJ22_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS06165	COG3708	Transcriptional regulator
IRJ22_RS06175	COG2378	regulation of single-species biofilm formation
IRJ22_RS06185	COG0640	Transcriptional regulator
IRJ22_RS06190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS06200	COG0531	amino acid
IRJ22_RS06205	COG0741	lytic transglycosylase activity
IRJ22_RS06210	COG1086	Polysaccharide biosynthesis protein
IRJ22_RS06230	COG2322	membrane
IRJ22_RS06245	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS06250	COG1388	LysM domain
IRJ22_RS06250	COG3584	3D domain protein
IRJ22_RS06255	COG0514	ATP-dependent DNA helicase (RecQ)
IRJ22_RS06275	COG2315	Protein conserved in bacteria
IRJ22_RS06290	COG2427	Protein of unknown function (DUF1641)
IRJ22_RS06295	COG3383	formate dehydrogenase (NAD+) activity
IRJ22_RS06320	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IRJ22_RS06365	COG0402	S-adenosylhomocysteine deaminase activity
IRJ22_RS06380	COG2267	carboxylic ester hydrolase activity
IRJ22_RS06395	COG1280	lysine exporter protein (LysE YggA)
IRJ22_RS06400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRJ22_RS06410	COG0574	Belongs to the PEP-utilizing enzyme family
IRJ22_RS06410	COG3848	Pyruvate phosphate dikinase
IRJ22_RS06415	COG1309	transcriptional regulator
IRJ22_RS06430	COG2318	DinB family
IRJ22_RS06435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IRJ22_RS06440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRJ22_RS06455	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS06460	COG2814	Major facilitator Superfamily
IRJ22_RS06475	COG1657	PFAM Prenyltransferase squalene oxidase
IRJ22_RS06480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IRJ22_RS06490	COG0733	neurotransmitter:sodium symporter activity
IRJ22_RS06495	COG0385	Bile acid
IRJ22_RS06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRJ22_RS06505	COG0567	Dehydrogenase, E1 component
IRJ22_RS06510	COG4548	von Willebrand factor, type A
IRJ22_RS06515	COG0714	Associated with various cellular activities
IRJ22_RS06520	COG2032	superoxide dismutase activity
IRJ22_RS06525	COG1388	LysM domain
IRJ22_RS06525	COG0791	NLP P60 protein
IRJ22_RS06530	COG0534	Mate efflux family protein
IRJ22_RS06535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRJ22_RS06540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRJ22_RS06550	COG2962	Rard protein
IRJ22_RS06560	COG4305	rare lipoprotein A
IRJ22_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS06575	COG1733	regulation of RNA biosynthetic process
IRJ22_RS06580	COG0778	Nitroreductase
IRJ22_RS06585	COG0400	carboxylic ester hydrolase activity
IRJ22_RS06595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS06600	COG3409	Peptidoglycan-binding domain 1 protein
IRJ22_RS06600	COG0793	Belongs to the peptidase S41A family
IRJ22_RS06605	COG2226	methyltransferase
IRJ22_RS06615	COG1876	peptidase activity
IRJ22_RS06620	COG0813	purine-nucleoside phosphorylase activity
IRJ22_RS06625	COG0701	Predicted permease
IRJ22_RS06645	COG0671	phosphoesterase, PA-phosphatase related
IRJ22_RS06665	COG4479	Belongs to the UPF0346 family
IRJ22_RS06675	COG1509	lysine 2,3-aminomutase activity
IRJ22_RS06680	COG0456	acetyltransferase
IRJ22_RS06685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRJ22_RS06690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IRJ22_RS06695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRJ22_RS06700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRJ22_RS06715	COG0456	acetyltransferase
IRJ22_RS06720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRJ22_RS06725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRJ22_RS06730	COG1846	Transcriptional regulator
IRJ22_RS06740	COG3706	GGDEF domain
IRJ22_RS06745	COG0534	Mate efflux family protein
IRJ22_RS06760	COG4698	Protein conserved in bacteria
IRJ22_RS06765	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS06770	COG1999	signal sequence binding
IRJ22_RS06785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IRJ22_RS06790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IRJ22_RS06795	COG1272	protein, Hemolysin III
IRJ22_RS06800	COG0204	Acyl-transferase
IRJ22_RS06805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IRJ22_RS06810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRJ22_RS06820	COG2136	Putative SAM-dependent methyltransferase
IRJ22_RS06820	COG2521	methyltransferase
IRJ22_RS06830	COG0129	dihydroxy-acid dehydratase activity
IRJ22_RS06835	COG1413	lyase activity
IRJ22_RS06840	COG1418	mRNA catabolic process
IRJ22_RS06845	COG0386	Belongs to the glutathione peroxidase family
IRJ22_RS06850	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IRJ22_RS06855	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IRJ22_RS06860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRJ22_RS06870	COG1278	Cold shock
IRJ22_RS06890	COG0328	RNA-DNA hybrid ribonuclease activity
IRJ22_RS06895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IRJ22_RS06900	COG0328	RNA-DNA hybrid ribonuclease activity
IRJ22_RS06910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRJ22_RS06925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRJ22_RS06935	COG1755	Isoprenylcysteine carboxyl methyltransferase
IRJ22_RS06940	COG3424	synthase
IRJ22_RS06945	COG0456	acetyltransferase
IRJ22_RS06950	COG2233	PERMEase
IRJ22_RS06955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRJ22_RS06960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IRJ22_RS06965	COG1199	ATP-dependent helicase activity
IRJ22_RS06980	COG0116	Belongs to the methyltransferase superfamily
IRJ22_RS06990	COG3599	regulation of cell shape
IRJ22_RS06995	COG4474	Belongs to the UPF0398 family
IRJ22_RS07005	COG3359	exonuclease
IRJ22_RS07015	COG2190	(PTS) system
IRJ22_RS07020	COG0071	Belongs to the small heat shock protein (HSP20) family
IRJ22_RS07055	COG3331	DNA recombination
IRJ22_RS07060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRJ22_RS07060	COG4499	WXG100 protein secretion system (Wss), protein YukC
IRJ22_RS07070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IRJ22_RS07075	COG3935	DnaD domain protein
IRJ22_RS07080	COG0017	Asparaginyl-tRNA synthetase
IRJ22_RS07085	COG0436	Aminotransferase
IRJ22_RS07090	COG5353	protein conserved in bacteria
IRJ22_RS07100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IRJ22_RS07100	COG1199	ATP-dependent helicase activity
IRJ22_RS07105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IRJ22_RS07110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IRJ22_RS07115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IRJ22_RS07125	COG0617	tRNA 3'-terminal CCA addition
IRJ22_RS07130	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS07135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRJ22_RS07140	COG1803	Methylglyoxal synthase
IRJ22_RS07145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IRJ22_RS07150	COG1694	Mazg nucleotide pyrophosphohydrolase
IRJ22_RS07155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS07165	COG4347	Protein of unknown function (DUF1405)
IRJ22_RS07175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IRJ22_RS07175	COG2010	Cytochrome c
IRJ22_RS07180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IRJ22_RS07185	COG0723	plastoquinol--plastocyanin reductase activity
IRJ22_RS07195	COG5582	Belongs to the UPF0302 family
IRJ22_RS07200	COG0457	Tetratricopeptide repeat
IRJ22_RS07205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IRJ22_RS07210	COG0287	Prephenate dehydrogenase
IRJ22_RS07215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRJ22_RS07220	COG0159	tryptophan synthase activity
IRJ22_RS07225	COG0133	tryptophan synthase activity
IRJ22_RS07230	COG0135	phosphoribosylanthranilate isomerase activity
IRJ22_RS07235	COG0134	indole-3-glycerol-phosphate synthase activity
IRJ22_RS07240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRJ22_RS07245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRJ22_RS07250	COG4401	Chorismate mutase type I
IRJ22_RS07255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IRJ22_RS07260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IRJ22_RS07265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRJ22_RS07270	COG0105	UTP biosynthetic process
IRJ22_RS07275	COG0142	geranyltranstransferase activity
IRJ22_RS07280	COG2226	methyltransferase
IRJ22_RS07285	COG0142	geranyltranstransferase activity
IRJ22_RS07300	COG0776	regulation of translation
IRJ22_RS07305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRJ22_RS07320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IRJ22_RS07325	COG1160	GTP binding
IRJ22_RS07350	COG1304	FMN binding
IRJ22_RS07355	COG0539	negative regulation of cytoplasmic translation
IRJ22_RS07360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IRJ22_RS07370	COG2959	enzyme of heme biosynthesis
IRJ22_RS07375	COG3409	Peptidoglycan-binding domain 1 protein
IRJ22_RS07375	COG3773	Cell wall hydrolase
IRJ22_RS07380	COG2339	peptidase activity
IRJ22_RS07390	COG0492	ferredoxin-NADP+ reductase activity
IRJ22_RS07395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRJ22_RS07400	COG4862	establishment of competence for transformation
IRJ22_RS07405	COG1408	metallophosphoesterase
IRJ22_RS07415	COG1388	LysM domain
IRJ22_RS07420	COG1266	CAAX protease self-immunity
IRJ22_RS07425	COG0514	ATP-dependent DNA helicase (RecQ)
IRJ22_RS07430	COG4955	Helix-turn-helix domain
IRJ22_RS07435	COG1141	Ferredoxin
IRJ22_RS07440	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IRJ22_RS07445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRJ22_RS07450	COG0739	heme binding
IRJ22_RS07460	COG1595	DNA-templated transcription, initiation
IRJ22_RS07465	COG1316	TRANSCRIPTIONal
IRJ22_RS07485	COG5002	protein histidine kinase activity
IRJ22_RS07490	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS07495	COG5002	protein histidine kinase activity
IRJ22_RS07500	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS07505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRJ22_RS07510	COG1333	cytochrome c biogenesis protein
IRJ22_RS07515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS07520	COG1187	pseudouridine synthase activity
IRJ22_RS07525	COG0700	Nucleoside recognition
IRJ22_RS07530	COG2715	membrane protein required for spore maturation
IRJ22_RS07535	COG1686	Belongs to the peptidase S11 family
IRJ22_RS07545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IRJ22_RS07550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IRJ22_RS07560	COG1547	Domain of unknown function (DUF309)
IRJ22_RS07565	COG0456	acetyltransferase
IRJ22_RS07570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IRJ22_RS07575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRJ22_RS07575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRJ22_RS07580	COG0307	riboflavin synthase, alpha
IRJ22_RS07585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRJ22_RS07585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRJ22_RS07610	COG0457	Tetratricopeptide repeat
IRJ22_RS07615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRJ22_RS07620	COG4086	secreted protein
IRJ22_RS07625	COG4195	phage-related replication protein
IRJ22_RS07630	COG0019	diaminopimelate decarboxylase activity
IRJ22_RS07640	COG0697	spore germination
IRJ22_RS07655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRJ22_RS07690	COG1686	Belongs to the peptidase S11 family
IRJ22_RS07695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IRJ22_RS07700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IRJ22_RS07705	COG4974	Belongs to the 'phage' integrase family
IRJ22_RS07715	COG0735	belongs to the Fur family
IRJ22_RS07720	COG1300	Membrane
IRJ22_RS07725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS07745	COG2153	protein acetylation
IRJ22_RS07750	COG1379	DNA repair
IRJ22_RS07755	COG0494	nUDIX hydrolase
IRJ22_RS07765	COG1309	transcriptional regulator
IRJ22_RS07775	COG0667	Aldo Keto reductase
IRJ22_RS07785	COG1073	alpha beta
IRJ22_RS07795	COG4918	Iron-sulphur cluster biosynthesis
IRJ22_RS07805	COG0456	acetyltransferase
IRJ22_RS07805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IRJ22_RS07810	COG2329	Antibiotic biosynthesis monooxygenase
IRJ22_RS07815	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IRJ22_RS07825	COG0747	negative chemotaxis
IRJ22_RS07830	COG0601	transmembrane transport
IRJ22_RS07835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS07840	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS07845	COG0534	Mate efflux family protein
IRJ22_RS07860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRJ22_RS07870	COG2211	Major facilitator Superfamily
IRJ22_RS07875	COG0346	lactoylglutathione lyase activity
IRJ22_RS07880	COG1072	(Pantothenic acid kinase))
IRJ22_RS07890	COG1131	(ABC) transporter
IRJ22_RS07910	COG4195	phage-related replication protein
IRJ22_RS07915	COG0300	oxidoreductase activity
IRJ22_RS07920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS07925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRJ22_RS07930	COG4187	Peptidase family M20/M25/M40
IRJ22_RS07935	COG1902	pentaerythritol trinitrate reductase activity
IRJ22_RS07940	COG0596	Alpha beta hydrolase
IRJ22_RS07945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRJ22_RS07950	COG1234	tRNA 3'-trailer cleavage
IRJ22_RS07955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IRJ22_RS07970	COG2358	TRAP transporter, solute receptor (TAXI family
IRJ22_RS07975	COG2188	Transcriptional regulator
IRJ22_RS07980	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS07985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS07990	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRJ22_RS07995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS08000	COG1785	Belongs to the alkaline phosphatase family
IRJ22_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS08010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IRJ22_RS08015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRJ22_RS08025	COG0706	membrane insertase activity
IRJ22_RS08030	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRJ22_RS08035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRJ22_RS08045	COG4129	membrane
IRJ22_RS08050	COG1126	abc transporter atp-binding protein
IRJ22_RS08055	COG0765	amino acid transport
IRJ22_RS08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRJ22_RS08070	COG1597	lipid kinase activity
IRJ22_RS08075	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRJ22_RS08080	COG0022	dehydrogenase e1 component
IRJ22_RS08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRJ22_RS08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRJ22_RS08095	COG3426	butyrate kinase activity
IRJ22_RS08105	COG0280	phosphate acetyltransferase
IRJ22_RS08110	COG3290	protein histidine kinase activity
IRJ22_RS08110	COG3829	transcription factor binding
IRJ22_RS08120	COG0584	glycerophosphoryl diester phosphodiesterase
IRJ22_RS08125	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS08140	COG1045	serine acetyltransferase
IRJ22_RS08150	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS08155	COG0750	zinc metalloprotease
IRJ22_RS08160	COG0497	DNA recombination
IRJ22_RS08165	COG1438	arginine binding
IRJ22_RS08170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IRJ22_RS08175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IRJ22_RS08180	COG0142	geranyltranstransferase activity
IRJ22_RS08185	COG1722	exodeoxyribonuclease VII activity
IRJ22_RS08190	COG1570	exodeoxyribonuclease VII activity
IRJ22_RS08195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IRJ22_RS08200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRJ22_RS08205	COG1302	Protein conserved in bacteria
IRJ22_RS08210	COG0439	Biotin carboxylase
IRJ22_RS08215	COG0511	ligase activity, forming carbon-carbon bonds
IRJ22_RS08255	COG3854	ATPases associated with a variety of cellular activities
IRJ22_RS08265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IRJ22_RS08270	COG0006	proline dipeptidase activity
IRJ22_RS08275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IRJ22_RS08285	COG3872	metal-dependent enzyme
IRJ22_RS08295	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRJ22_RS08300	COG1321	iron dependent repressor
IRJ22_RS08305	COG0095	Lipoate-protein ligase
IRJ22_RS08310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRJ22_RS08315	COG2113	Glycine betaine
IRJ22_RS08320	COG4176	ABC-type proline glycine betaine transport system permease component
IRJ22_RS08325	COG4175	Glycine betaine
IRJ22_RS08325	COG0517	IMP dehydrogenase activity
IRJ22_RS08330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRJ22_RS08335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRJ22_RS08340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IRJ22_RS08345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRJ22_RS08370	COG0681	Belongs to the peptidase S26 family
IRJ22_RS08395	COG4940	Competence protein ComGF
IRJ22_RS08405	COG4970	Tfp pilus assembly protein FimT
IRJ22_RS08410	COG4537	Required for transformation and DNA binding
IRJ22_RS08415	COG1459	type II secretion system
IRJ22_RS08420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IRJ22_RS08425	COG1366	Belongs to the anti-sigma-factor antagonist family
IRJ22_RS08435	COG1393	Belongs to the ArsC family
IRJ22_RS08445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS08455	COG0011	TIGRFAM Protein of
IRJ22_RS08465	COG2866	Carboxypeptidase
IRJ22_RS08470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS08480	COG1368	sulfuric ester hydrolase activity
IRJ22_RS08485	COG1940	carbohydrate kinase activity
IRJ22_RS08490	COG4483	Protein conserved in bacteria
IRJ22_RS08495	COG0697	spore germination
IRJ22_RS08500	COG0457	Tetratricopeptide repeat
IRJ22_RS08500	COG0705	Rhomboid family
IRJ22_RS08510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IRJ22_RS08515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRJ22_RS08520	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS08535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRJ22_RS08540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRJ22_RS08545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRJ22_RS08550	COG0581	inorganic phosphate transmembrane transporter activity
IRJ22_RS08555	COG0573	inorganic phosphate transmembrane transporter activity
IRJ22_RS08560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IRJ22_RS08565	COG0768	penicillin binding
IRJ22_RS08570	COG0477	Major facilitator Superfamily
IRJ22_RS08575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IRJ22_RS08580	COG2839	Protein conserved in bacteria
IRJ22_RS08585	COG5521	maltodextrose utilization protein MalA
IRJ22_RS08590	COG1388	LysM domain
IRJ22_RS08595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IRJ22_RS08600	COG4709	membrane
IRJ22_RS08605	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IRJ22_RS08610	COG0735	belongs to the Fur family
IRJ22_RS08615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRJ22_RS08620	COG1121	(ABC) transporter
IRJ22_RS08625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS08635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRJ22_RS08640	COG0513	Belongs to the DEAD box helicase family
IRJ22_RS08650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IRJ22_RS08655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IRJ22_RS08660	COG2384	SAM-dependent methyltransferase
IRJ22_RS08700	COG5444	nuclease activity
IRJ22_RS08715	COG2010	Cytochrome c
IRJ22_RS08720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRJ22_RS08725	COG0358	DNA primase activity
IRJ22_RS08730	COG1671	Belongs to the UPF0178 family
IRJ22_RS08735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IRJ22_RS08740	COG0517	IMP dehydrogenase activity
IRJ22_RS08745	COG0751	glycine-tRNA ligase activity
IRJ22_RS08750	COG0752	glycyl-tRNA synthetase alpha subunit
IRJ22_RS08755	COG1381	Involved in DNA repair and RecF pathway recombination
IRJ22_RS08765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IRJ22_RS08770	COG0295	cytidine deaminase activity
IRJ22_RS08775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IRJ22_RS08780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IRJ22_RS08785	COG1480	7TM receptor with intracellular HD hydrolase
IRJ22_RS08790	COG1702	phosphate starvation-inducible protein PhoH
IRJ22_RS08795	COG0561	phosphatase activity
IRJ22_RS08810	COG4864	UPF0365 protein
IRJ22_RS08815	COG1030	water channel activity
IRJ22_RS08820	COG1610	YqeY-like protein
IRJ22_RS08825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IRJ22_RS08830	COG1283	sodium-dependent phosphate transmembrane transporter activity
IRJ22_RS08835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRJ22_RS08840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRJ22_RS08845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IRJ22_RS08850	COG2264	protein methyltransferase activity
IRJ22_RS08855	COG0484	heat shock protein binding
IRJ22_RS08860	COG0443	Heat shock 70 kDa protein
IRJ22_RS08865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IRJ22_RS08870	COG1420	regulation of RNA biosynthetic process
IRJ22_RS08875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRJ22_RS08880	COG0481	GTPase activity
IRJ22_RS08890	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS08895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IRJ22_RS08900	COG0268	Binds directly to 16S ribosomal RNA
IRJ22_RS08905	COG1466	dna polymerase III delta subunit
IRJ22_RS08915	COG2333	competence protein COMEC
IRJ22_RS08915	COG0658	competence protein
IRJ22_RS08920	COG2131	deaminase
IRJ22_RS08925	COG1596	polysaccharide export
IRJ22_RS08925	COG1555	photosystem II stabilization
IRJ22_RS08930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRJ22_RS08935	COG2226	methyltransferase
IRJ22_RS08940	COG0799	negative regulation of ribosome biogenesis
IRJ22_RS08945	COG1713	HD superfamily hydrolase involved in NAD metabolism
IRJ22_RS08950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRJ22_RS08955	COG1534	Rna-binding protein
IRJ22_RS08960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IRJ22_RS08965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRJ22_RS08970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IRJ22_RS08985	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS08990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRJ22_RS08995	COG5609	conserved protein (DUF2294)
IRJ22_RS09000	COG3383	formate dehydrogenase (NAD+) activity
IRJ22_RS09005	COG2427	Protein of unknown function (DUF1641)
IRJ22_RS09025	COG1247	-acetyltransferase
IRJ22_RS09035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRJ22_RS09040	COG3616	Alanine racemase, N-terminal domain
IRJ22_RS09045	COG0251	oxidation-reduction process
IRJ22_RS09055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRJ22_RS09060	COG0251	oxidation-reduction process
IRJ22_RS09080	COG4978	Transcriptional regulator
IRJ22_RS09080	COG0789	Transcriptional regulator
IRJ22_RS09085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRJ22_RS09085	COG0425	Belongs to the sulfur carrier protein TusA family
IRJ22_RS09095	COG2197	response regulator
IRJ22_RS09100	COG4585	Histidine kinase
IRJ22_RS09105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS09110	COG0730	response to heat
IRJ22_RS09115	COG0425	Belongs to the sulfur carrier protein TusA family
IRJ22_RS09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS09120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRJ22_RS09125	COG0425	Belongs to the sulfur carrier protein TusA family
IRJ22_RS09125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRJ22_RS09130	COG2210	Belongs to the sulfur carrier protein TusA family
IRJ22_RS09135	COG1937	Protein conserved in bacteria
IRJ22_RS09175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IRJ22_RS09180	COG0113	porphobilinogen synthase activity
IRJ22_RS09185	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRJ22_RS09190	COG1121	(ABC) transporter
IRJ22_RS09195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRJ22_RS09205	COG1942	4-Oxalocrotonate Tautomerase
IRJ22_RS09215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IRJ22_RS09220	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IRJ22_RS09225	COG1733	regulation of RNA biosynthetic process
IRJ22_RS09230	COG3239	Fatty acid desaturase
IRJ22_RS09235	COG4585	Histidine kinase
IRJ22_RS09240	COG2197	response regulator
IRJ22_RS09245	COG0492	ferredoxin-NADP+ reductase activity
IRJ22_RS09250	COG0747	negative chemotaxis
IRJ22_RS09255	COG0601	transmembrane transport
IRJ22_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS09265	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS09270	COG4608	Belongs to the ABC transporter superfamily
IRJ22_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS09305	COG2124	cytochrome p450
IRJ22_RS09310	COG0730	response to heat
IRJ22_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS09325	COG1621	beta-fructofuranosidase activity
IRJ22_RS09330	COG3716	PTS system mannose fructose sorbose family IID component
IRJ22_RS09335	COG3715	PTS system
IRJ22_RS09340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS09345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS09350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IRJ22_RS09350	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IRJ22_RS09370	COG2169	Transcriptional regulator
IRJ22_RS09375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRJ22_RS09380	COG0656	L-ascorbic acid biosynthetic process
IRJ22_RS09385	COG2814	Major facilitator Superfamily
IRJ22_RS09390	COG1733	regulation of RNA biosynthetic process
IRJ22_RS09395	COG3340	Belongs to the peptidase S51 family
IRJ22_RS09400	COG1587	Uroporphyrinogen-III synthase
IRJ22_RS09410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS09415	COG0583	DNA-binding transcription factor activity
IRJ22_RS09420	COG2814	Major facilitator Superfamily
IRJ22_RS09430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IRJ22_RS09430	COG2124	cytochrome p450
IRJ22_RS09435	COG1309	transcriptional regulator
IRJ22_RS09440	COG1404	Belongs to the peptidase S8 family
IRJ22_RS09445	COG2226	methyltransferase
IRJ22_RS09470	COG0626	cystathionine gamma-synthase activity
IRJ22_RS09475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRJ22_RS09480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRJ22_RS09485	COG2226	methyltransferase
IRJ22_RS09500	COG0768	penicillin binding
IRJ22_RS09505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IRJ22_RS09510	COG0572	uridine kinase
IRJ22_RS09515	COG0826	peptidase U32
IRJ22_RS09520	COG0826	peptidase U32
IRJ22_RS09525	COG4122	O-methyltransferase activity
IRJ22_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRJ22_RS09535	COG3906	Belongs to the UPF0473 family
IRJ22_RS09540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IRJ22_RS09545	COG4472	Bacterial protein of unknown function (DUF965)
IRJ22_RS09550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRJ22_RS09555	COG0628	permease
IRJ22_RS09570	COG3881	PFAM PRC-barrel domain
IRJ22_RS09575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IRJ22_RS09580	COG0457	Tetratricopeptide repeat
IRJ22_RS09585	COG0482	sulfurtransferase activity
IRJ22_RS09590	COG1104	cysteine desulfurase activity
IRJ22_RS09595	COG1959	2 iron, 2 sulfur cluster binding
IRJ22_RS09600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IRJ22_RS09605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IRJ22_RS09615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IRJ22_RS09620	COG0124	histidyl-tRNA synthetase
IRJ22_RS09630	COG4991	sh3 domain protein
IRJ22_RS09630	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS09630	COG3103	Sh3 type 3 domain protein
IRJ22_RS09635	COG1490	D-aminoacyl-tRNA deacylase activity
IRJ22_RS09640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IRJ22_RS09645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRJ22_RS09650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IRJ22_RS09650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IRJ22_RS09655	COG5416	Lipopolysaccharide assembly protein A domain
IRJ22_RS09660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRJ22_RS09660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRJ22_RS09670	COG2244	polysaccharide biosynthetic process
IRJ22_RS09675	COG2323	membrane
IRJ22_RS09685	COG1862	Preprotein translocase
IRJ22_RS09690	COG0343	queuine tRNA-ribosyltransferase activity
IRJ22_RS09695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IRJ22_RS09705	COG2255	four-way junction helicase activity
IRJ22_RS09710	COG0632	four-way junction helicase activity
IRJ22_RS09720	COG2112	serine threonine protein kinase
IRJ22_RS09730	COG2318	DinB family
IRJ22_RS09735	COG4195	phage-related replication protein
IRJ22_RS09750	COG0217	transcriptional regulatory protein
IRJ22_RS09760	COG1388	LysM domain
IRJ22_RS09765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IRJ22_RS09770	COG0157	Belongs to the NadC ModD family
IRJ22_RS09775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IRJ22_RS09780	COG1104	cysteine desulfurase activity
IRJ22_RS09785	COG1827	regulation of RNA biosynthetic process
IRJ22_RS09790	COG0077	Prephenate dehydratase
IRJ22_RS09795	COG4492	Belongs to the UPF0735 family
IRJ22_RS09800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IRJ22_RS09805	COG3290	protein histidine kinase activity
IRJ22_RS09810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IRJ22_RS09815	COG2868	ribosomal protein
IRJ22_RS09820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IRJ22_RS09825	COG1994	Peptidase M50
IRJ22_RS09830	COG0739	heme binding
IRJ22_RS09835	COG3832	glyoxalase III activity
IRJ22_RS09840	COG0640	Transcriptional regulator
IRJ22_RS09845	COG2894	cell division
IRJ22_RS09850	COG0850	regulation of cytokinetic process
IRJ22_RS09855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IRJ22_RS09865	COG1077	Cell shape determining protein MreB Mrl
IRJ22_RS09870	COG2003	Belongs to the UPF0758 family
IRJ22_RS09875	COG0424	maF-like protein
IRJ22_RS09885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IRJ22_RS09890	COG0285	dihydrofolate synthase activity
IRJ22_RS09895	COG0525	valine-tRNA ligase activity
IRJ22_RS09905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IRJ22_RS09910	COG1388	LysM domain
IRJ22_RS09915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRJ22_RS09920	COG0113	porphobilinogen synthase activity
IRJ22_RS09925	COG1587	Uroporphyrinogen-III synthase
IRJ22_RS09930	COG0181	hydroxymethylbilane synthase activity
IRJ22_RS09935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRJ22_RS09940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IRJ22_RS09950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IRJ22_RS09955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IRJ22_RS09960	COG0470	DNA polymerase III
IRJ22_RS09960	COG1067	ATP-dependent peptidase activity
IRJ22_RS09965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IRJ22_RS09970	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRJ22_RS09975	COG0457	Tetratricopeptide repeat
IRJ22_RS09975	COG1477	protein flavinylation
IRJ22_RS09980	COG0066	3-isopropylmalate dehydratase activity
IRJ22_RS09985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IRJ22_RS09990	COG0473	3-isopropylmalate dehydrogenase activity
IRJ22_RS09995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRJ22_RS10000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IRJ22_RS10005	COG0440	acetolactate synthase activity
IRJ22_RS10010	COG0028	Belongs to the TPP enzyme family
IRJ22_RS10015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRJ22_RS10025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRJ22_RS10045	COG1783	phage Terminase large subunit
IRJ22_RS10085	COG5444	nuclease activity
IRJ22_RS10090	COG0457	Tetratricopeptide repeat
IRJ22_RS10115	COG0622	Phosphoesterase
IRJ22_RS10120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IRJ22_RS10125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IRJ22_RS10130	COG5401	PFAM Sporulation and spore germination
IRJ22_RS10135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IRJ22_RS10140	COG1846	Transcriptional regulator
IRJ22_RS10145	COG2197	response regulator
IRJ22_RS10150	COG4221	oxidoreductase activity
IRJ22_RS10155	COG0824	Thioesterase
IRJ22_RS10160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IRJ22_RS10165	COG1053	succinate dehydrogenase
IRJ22_RS10170	COG2009	succinate dehydrogenase
IRJ22_RS10175	COG1719	4-vinyl reductase, 4VR
IRJ22_RS10180	COG0527	aspartate kinase activity
IRJ22_RS10185	COG0322	excinuclease ABC activity
IRJ22_RS10190	COG3118	belongs to the thioredoxin family
IRJ22_RS10195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRJ22_RS10200	COG2086	electron transfer activity
IRJ22_RS10205	COG1024	Enoyl-CoA hydratase
IRJ22_RS10210	COG1309	transcriptional regulator
IRJ22_RS10215	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS10220	COG3766	membrane
IRJ22_RS10225	COG1193	negative regulation of DNA recombination
IRJ22_RS10230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IRJ22_RS10230	COG1796	DNA polymerase
IRJ22_RS10235	COG1286	toxin biosynthetic process
IRJ22_RS10240	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IRJ22_RS10245	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IRJ22_RS10265	COG1137	ATPase activity
IRJ22_RS10280	COG0072	phenylalanine-tRNA ligase activity
IRJ22_RS10280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRJ22_RS10285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IRJ22_RS10290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRJ22_RS10300	COG1966	Carbon starvation protein
IRJ22_RS10315	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS10320	COG1175	transmembrane transport
IRJ22_RS10325	COG1653	transport
IRJ22_RS10330	COG0371	Dehydrogenase
IRJ22_RS10335	COG0235	Class ii aldolase
IRJ22_RS10340	COG1069	ribulokinase activity
IRJ22_RS10345	COG2160	L-arabinose isomerase activity
IRJ22_RS10350	COG3507	Belongs to the glycosyl hydrolase 43 family
IRJ22_RS10355	COG1363	Peptidase, m42
IRJ22_RS10365	COG3326	Membrane
IRJ22_RS10370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IRJ22_RS10375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IRJ22_RS10380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IRJ22_RS10385	COG1346	cytolysis
IRJ22_RS10395	COG3540	Alkaline phosphatase
IRJ22_RS10400	COG3279	Response regulator of the LytR AlgR family
IRJ22_RS10405	COG3275	phosphorelay sensor kinase activity
IRJ22_RS10415	COG1011	Hydrolase
IRJ22_RS10420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRJ22_RS10430	COG0398	Pfam SNARE associated Golgi protein
IRJ22_RS10435	COG1484	DNA-dependent DNA replication
IRJ22_RS10440	COG3611	Membrane attachment protein
IRJ22_RS10445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IRJ22_RS10455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IRJ22_RS10460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IRJ22_RS10465	COG3866	Pectate lyase
IRJ22_RS10470	COG0237	dephospho-CoA kinase activity
IRJ22_RS10475	COG1971	Probably functions as a manganese efflux pump
IRJ22_RS10480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRJ22_RS10485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRJ22_RS10485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRJ22_RS10490	COG5002	protein histidine kinase activity
IRJ22_RS10495	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS10500	COG0039	L-malate dehydrogenase activity
IRJ22_RS10505	COG0538	isocitrate dehydrogenase activity
IRJ22_RS10510	COG0372	Belongs to the citrate synthase family
IRJ22_RS10515	COG2707	UPF0756 membrane protein
IRJ22_RS10520	COG0628	permease
IRJ22_RS10525	COG3030	protein affecting phage T7 exclusion by the F plasmid
IRJ22_RS10535	COG0205	6-phosphofructokinase activity
IRJ22_RS10540	COG0825	malonyl-CoA metabolic process
IRJ22_RS10545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IRJ22_RS10550	COG0281	malic enzyme
IRJ22_RS10555	COG0587	DNA-directed DNA polymerase activity
IRJ22_RS10575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRJ22_RS10585	COG4109	DRTGG domain
IRJ22_RS10590	COG1695	Transcriptional regulator
IRJ22_RS10595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRJ22_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS10610	COG0165	Argininosuccinate lyase
IRJ22_RS10615	COG0137	argininosuccinate synthase activity
IRJ22_RS10620	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRJ22_RS10625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IRJ22_RS10630	COG0827	DNA restriction-modification system
IRJ22_RS10635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IRJ22_RS10640	COG3874	Sporulation protein YtfJ
IRJ22_RS10650	COG1714	RDD family
IRJ22_RS10655	COG0616	signal peptide processing
IRJ22_RS10660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRJ22_RS10675	COG0477	Major facilitator Superfamily
IRJ22_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRJ22_RS10695	COG0301	tRNA thio-modification
IRJ22_RS10700	COG1104	cysteine desulfurase activity
IRJ22_RS10705	COG1114	Component of the transport system for branched-chain amino acids
IRJ22_RS10715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IRJ22_RS10720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IRJ22_RS10725	COG1309	transcriptional regulator
IRJ22_RS10730	COG1956	GAF domain-containing protein
IRJ22_RS10735	COG2199	diguanylate cyclase activity
IRJ22_RS10735	COG2203	Gaf domain
IRJ22_RS10740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IRJ22_RS10750	COG3152	Membrane
IRJ22_RS10755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRJ22_RS10760	COG1522	sequence-specific DNA binding
IRJ22_RS10770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IRJ22_RS10775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRJ22_RS10780	COG0454	-acetyltransferase
IRJ22_RS10785	COG0517	IMP dehydrogenase activity
IRJ22_RS10790	COG0123	including yeast histone deacetylase and acetoin utilization protein
IRJ22_RS10795	COG1360	Flagellar Motor Protein
IRJ22_RS10800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRJ22_RS10805	COG1609	Transcriptional regulator
IRJ22_RS10810	COG1605	Chorismate mutase
IRJ22_RS10810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IRJ22_RS10820	COG3118	belongs to the thioredoxin family
IRJ22_RS10825	COG4980	gas vesicle protein
IRJ22_RS10830	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IRJ22_RS10835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IRJ22_RS10840	COG1674	ftsk spoiiie
IRJ22_RS10845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRJ22_RS10850	COG4848	Belongs to the UPF0354 family
IRJ22_RS10855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS10865	COG1363	Peptidase, m42
IRJ22_RS10870	COG5584	Small secreted protein
IRJ22_RS10875	COG0281	malic enzyme
IRJ22_RS10880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS10885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IRJ22_RS10895	COG0510	thiamine kinase activity
IRJ22_RS10900	COG1523	belongs to the glycosyl hydrolase 13 family
IRJ22_RS10905	COG1597	lipid kinase activity
IRJ22_RS10915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRJ22_RS10920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRJ22_RS10935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRJ22_RS10940	COG2252	PERMEase
IRJ22_RS10945	COG1349	DNA-binding transcription factor activity
IRJ22_RS10950	COG1187	pseudouridine synthase activity
IRJ22_RS10955	COG2244	polysaccharide biosynthetic process
IRJ22_RS10960	COG2081	HI0933 family
IRJ22_RS10965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IRJ22_RS10975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRJ22_RS10980	COG0457	Tetratricopeptide repeat
IRJ22_RS10990	COG5578	integral membrane protein
IRJ22_RS10995	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS11000	COG1653	transport
IRJ22_RS11005	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IRJ22_RS11010	COG4209	transmembrane transport
IRJ22_RS11015	COG2207	Transcriptional regulator
IRJ22_RS11020	COG1653	transport
IRJ22_RS11025	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS11030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRJ22_RS11035	COG1073	alpha beta
IRJ22_RS11050	COG0583	DNA-binding transcription factor activity
IRJ22_RS11055	COG0346	lactoylglutathione lyase activity
IRJ22_RS11060	COG0495	leucyl-tRNA aminoacylation
IRJ22_RS11070	COG2814	Major facilitator Superfamily
IRJ22_RS11080	COG2433	Pfam Transposase IS66
IRJ22_RS11085	COG0577	efflux transmembrane transporter activity
IRJ22_RS11090	COG1136	(ABC) transporter
IRJ22_RS11100	COG1131	(ABC) transporter
IRJ22_RS11105	COG1725	Transcriptional regulator
IRJ22_RS11115	COG1242	4 iron, 4 sulfur cluster binding
IRJ22_RS11120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IRJ22_RS11125	COG1301	dicarboxylic acid transport
IRJ22_RS11135	COG2267	carboxylic ester hydrolase activity
IRJ22_RS11140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IRJ22_RS11145	COG0671	phosphoesterase, PA-phosphatase related
IRJ22_RS11150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRJ22_RS11150	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS11155	COG0367	asparagine synthase
IRJ22_RS11160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IRJ22_RS11165	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IRJ22_RS11170	COG1301	dicarboxylic acid transport
IRJ22_RS11180	COG1506	peptidase
IRJ22_RS11185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRJ22_RS11190	COG1116	anion transmembrane transporter activity
IRJ22_RS11195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRJ22_RS11200	COG0494	nUDIX hydrolase
IRJ22_RS11210	COG4824	toxin secretion phage lysis holin
IRJ22_RS11215	COG0783	Belongs to the Dps family
IRJ22_RS11230	COG1854	S-ribosylhomocysteine lyase activity
IRJ22_RS11235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IRJ22_RS11240	COG0288	reversible hydration of carbon dioxide
IRJ22_RS11245	COG0523	cobalamin synthesis protein
IRJ22_RS11250	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRJ22_RS11255	COG0254	rRNA binding
IRJ22_RS11260	COG1271	oxidase subunit
IRJ22_RS11265	COG1294	oxidase, subunit
IRJ22_RS11280	COG4948	Mandelate Racemase Muconate Lactonizing
IRJ22_RS11285	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS11290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IRJ22_RS11295	COG0596	Alpha beta hydrolase
IRJ22_RS11300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IRJ22_RS11305	COG1169	isochorismate synthase
IRJ22_RS11310	COG1575	Belongs to the MenA family. Type 1 subfamily
IRJ22_RS11315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRJ22_RS11320	COG0058	SHG alpha-glucan phosphorylase activity
IRJ22_RS11325	COG0297	glycogen (starch) synthase activity
IRJ22_RS11330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IRJ22_RS11335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IRJ22_RS11340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IRJ22_RS11465	COG1609	Transcriptional regulator
IRJ22_RS11470	COG3859	Proton-coupled thiamine transporter YuaJ
IRJ22_RS11475	COG3764	Sortase (surface protein transpeptidase)
IRJ22_RS11490	COG0457	Tetratricopeptide repeat
IRJ22_RS11495	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IRJ22_RS11500	COG0569	domain protein
IRJ22_RS11505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IRJ22_RS11515	COG2318	DinB family
IRJ22_RS11525	COG1454	alcohol dehydrogenase
IRJ22_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS11535	COG1510	regulation of RNA biosynthetic process
IRJ22_RS11545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IRJ22_RS11550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IRJ22_RS11555	COG2140	Oxalate decarboxylase
IRJ22_RS11565	COG1397	ADP-ribosylglycohydrolase
IRJ22_RS11600	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IRJ22_RS11615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRJ22_RS11620	COG0726	polysaccharide deacetylase
IRJ22_RS11625	COG1408	metallophosphoesterase
IRJ22_RS11630	COG1968	undecaprenyl-diphosphatase activity
IRJ22_RS11635	COG0628	permease
IRJ22_RS11640	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS11645	COG0693	protein deglycase activity
IRJ22_RS11650	COG0840	transmembrane signaling receptor activity
IRJ22_RS11655	COG0840	transmembrane signaling receptor activity
IRJ22_RS11660	COG0840	transmembrane signaling receptor activity
IRJ22_RS11670	COG2070	2-Nitropropane dioxygenase
IRJ22_RS11675	COG0432	Pfam Uncharacterised protein family UPF0047
IRJ22_RS11680	COG0366	Alpha amylase catalytic
IRJ22_RS11695	COG5297	Belongs to the glycosyl hydrolase family 6
IRJ22_RS11700	COG1253	flavin adenine dinucleotide binding
IRJ22_RS11705	COG2738	Putative neutral zinc metallopeptidase
IRJ22_RS11720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IRJ22_RS11730	COG2323	membrane
IRJ22_RS11735	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IRJ22_RS11745	COG0166	Belongs to the GPI family
IRJ22_RS11750	COG1979	alcohol dehydrogenase
IRJ22_RS11755	COG2155	Conserved Protein
IRJ22_RS11760	COG1098	S1 RNA binding domain
IRJ22_RS11765	COG0436	Aminotransferase
IRJ22_RS11770	COG1522	sequence-specific DNA binding
IRJ22_RS11775	COG2267	carboxylic ester hydrolase activity
IRJ22_RS11790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IRJ22_RS11805	COG5018	Exonuclease
IRJ22_RS11810	COG2814	Major facilitator Superfamily
IRJ22_RS11815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRJ22_RS11820	COG3011	Protein conserved in bacteria
IRJ22_RS11830	COG3290	protein histidine kinase activity
IRJ22_RS11835	COG4565	transcriptional regulatory protein
IRJ22_RS11845	COG1183	phosphatidylcholine synthase activity
IRJ22_RS11850	COG0586	Pfam SNARE associated Golgi protein
IRJ22_RS11855	COG0688	phosphatidylethanolamine metabolic process
IRJ22_RS11860	COG3493	citrate carrier protein
IRJ22_RS11870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IRJ22_RS11870	COG2111	Na H antiporter
IRJ22_RS11875	COG2111	Na H antiporter
IRJ22_RS11880	COG1006	Multisubunit Na H antiporter MnhC subunit
IRJ22_RS11885	COG0651	ATP synthesis coupled electron transport
IRJ22_RS11890	COG1863	multisubunit Na H antiporter MnhE subunit
IRJ22_RS11895	COG2212	antiporter activity
IRJ22_RS11900	COG1320	monovalent cation:proton antiporter activity
IRJ22_RS11905	COG2050	protein possibly involved in aromatic compounds catabolism
IRJ22_RS11910	COG2197	response regulator
IRJ22_RS11915	COG4585	Histidine kinase
IRJ22_RS11925	COG0142	geranyltranstransferase activity
IRJ22_RS11945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IRJ22_RS11950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IRJ22_RS11955	COG1335	isochorismatase
IRJ22_RS11960	COG5506	Protein of unknown function (DUF1694)
IRJ22_RS11975	COG0628	permease
IRJ22_RS11980	COG1959	2 iron, 2 sulfur cluster binding
IRJ22_RS11985	COG0657	acetylesterase activity
IRJ22_RS11995	COG1418	mRNA catabolic process
IRJ22_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS12010	COG1511	domain protein
IRJ22_RS12015	COG0433	COG0433 Predicted ATPase
IRJ22_RS12015	COG1674	ftsk spoiiie
IRJ22_RS12020	COG4499	WXG100 protein secretion system (Wss), protein YukC
IRJ22_RS12025	COG5417	Belongs to the EsaB family
IRJ22_RS12030	COG4842	Belongs to the WXG100 family
IRJ22_RS12035	COG1115	amino acid carrier protein
IRJ22_RS12040	COG2508	Transcriptional regulator
IRJ22_RS12040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRJ22_RS12045	COG0686	Belongs to the AlaDH PNT family
IRJ22_RS12055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRJ22_RS12060	COG1268	BioY protein
IRJ22_RS12065	COG2056	Na+-H+ antiporter family
IRJ22_RS12070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IRJ22_RS12075	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IRJ22_RS12080	COG3584	3D domain protein
IRJ22_RS12095	COG1252	NADH dehydrogenase
IRJ22_RS12100	COG0492	ferredoxin-NADP+ reductase activity
IRJ22_RS12115	COG0456	acetyltransferase
IRJ22_RS12120	COG0316	Belongs to the HesB IscA family
IRJ22_RS12125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IRJ22_RS12130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IRJ22_RS12135	COG4844	belongs to the
IRJ22_RS12140	COG1252	NADH dehydrogenase
IRJ22_RS12145	COG5646	InterPro IPR014922
IRJ22_RS12155	COG0457	Tetratricopeptide repeat
IRJ22_RS12160	COG3479	Phenolic acid decarboxylase
IRJ22_RS12170	COG4837	Protein of unknown function (DUF1462)
IRJ22_RS12180	COG0823	Involved in the tonB-independent uptake of proteins
IRJ22_RS12180	COG1506	peptidase
IRJ22_RS12180	COG4946	Tricorn protease homolog
IRJ22_RS12185	COG0083	homoserine kinase activity
IRJ22_RS12190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IRJ22_RS12195	COG0460	homoserine dehydrogenase
IRJ22_RS12205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IRJ22_RS12210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRJ22_RS12215	COG0647	UMP catabolic process
IRJ22_RS12220	COG2445	Protein of unknown function DUF86
IRJ22_RS12225	COG4470	Protein conserved in bacteria
IRJ22_RS12240	COG0739	heme binding
IRJ22_RS12250	COG0733	neurotransmitter:sodium symporter activity
IRJ22_RS12260	COG3377	Domain of unknown function (DUF1805)
IRJ22_RS12265	COG0737	Belongs to the 5'-nucleotidase family
IRJ22_RS12270	COG0730	response to heat
IRJ22_RS12275	COG1801	Protein of unknown function DUF72
IRJ22_RS12285	COG3226	Transcriptional regulator
IRJ22_RS12295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IRJ22_RS12300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRJ22_RS12305	COG2508	Transcriptional regulator
IRJ22_RS12310	COG2814	Major facilitator Superfamily
IRJ22_RS12315	COG1288	antiporter activity
IRJ22_RS12325	COG2356	endonuclease I
IRJ22_RS12335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRJ22_RS12350	COG0457	Tetratricopeptide repeat
IRJ22_RS12355	COG0719	Fe-S assembly protein
IRJ22_RS12360	COG0822	iron-sulfur transferase activity
IRJ22_RS12365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRJ22_RS12370	COG0719	Fe-S assembly protein
IRJ22_RS12375	COG0396	ATPase activity
IRJ22_RS12385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IRJ22_RS12390	COG1464	Belongs to the NlpA lipoprotein family
IRJ22_RS12395	COG2011	ABC-type metal ion transport system permease component
IRJ22_RS12400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IRJ22_RS12410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS12415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IRJ22_RS12425	COG0509	glycine decarboxylation via glycine cleavage system
IRJ22_RS12430	COG1393	Belongs to the ArsC family
IRJ22_RS12435	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS12440	COG0183	Belongs to the thiolase family
IRJ22_RS12445	COG1024	Enoyl-CoA hydratase
IRJ22_RS12445	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRJ22_RS12460	COG5577	PFAM Coat F domain
IRJ22_RS12475	COG1120	ATPase activity
IRJ22_RS12480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS12485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS12490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS12505	COG1686	Belongs to the peptidase S11 family
IRJ22_RS12510	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS12515	COG0783	Belongs to the Dps family
IRJ22_RS12520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRJ22_RS12525	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS12530	COG2205	protein histidine kinase activity
IRJ22_RS12530	COG2770	Histidine kinase
IRJ22_RS12540	COG1309	transcriptional regulator
IRJ22_RS12545	COG0114	fumarate hydratase activity
IRJ22_RS12555	COG0697	spore germination
IRJ22_RS12560	COG0814	amino acid
IRJ22_RS12575	COG2197	response regulator
IRJ22_RS12580	COG4585	Histidine kinase
IRJ22_RS12585	COG4758	membrane
IRJ22_RS12595	COG1842	Phage shock protein A
IRJ22_RS12600	COG4758	membrane
IRJ22_RS12605	COG4677	pectinesterase activity
IRJ22_RS12610	COG2096	Adenosyltransferase
IRJ22_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS12630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRJ22_RS12635	COG1120	ATPase activity
IRJ22_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS12645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS12650	COG1802	Transcriptional regulator
IRJ22_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS12660	COG2258	MOSC domain
IRJ22_RS12665	COG0583	DNA-binding transcription factor activity
IRJ22_RS12675	COG2721	sulfolactate sulfo-lyase activity
IRJ22_RS12680	COG0246	Mannitol dehydrogenase
IRJ22_RS12685	COG1609	Transcriptional regulator
IRJ22_RS12690	COG2211	Major facilitator Superfamily
IRJ22_RS12695	COG1904	glucuronate isomerase
IRJ22_RS12700	COG2205	protein histidine kinase activity
IRJ22_RS12705	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS12710	COG1120	ATPase activity
IRJ22_RS12715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS12725	COG0531	amino acid
IRJ22_RS12735	COG1988	membrane-bound metal-dependent
IRJ22_RS12740	COG1368	sulfuric ester hydrolase activity
IRJ22_RS12745	COG2814	Major facilitator Superfamily
IRJ22_RS12750	COG0656	L-ascorbic acid biosynthetic process
IRJ22_RS12755	COG1940	carbohydrate kinase activity
IRJ22_RS12760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRJ22_RS12770	COG3973	AAA domain
IRJ22_RS12775	COG2860	membrane
IRJ22_RS12785	COG0456	acetyltransferase
IRJ22_RS12790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IRJ22_RS12795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IRJ22_RS12800	COG2217	Heavy metal translocating P-type atpase
IRJ22_RS12805	COG1653	transport
IRJ22_RS12810	COG1175	transmembrane transport
IRJ22_RS12815	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS12820	COG1501	Belongs to the glycosyl hydrolase 31 family
IRJ22_RS12825	COG1472	Belongs to the glycosyl hydrolase 3 family
IRJ22_RS12830	COG1121	(ABC) transporter
IRJ22_RS12835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRJ22_RS12840	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRJ22_RS12855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IRJ22_RS12855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IRJ22_RS12860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS12860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRJ22_RS12860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS12880	COG2217	Heavy metal translocating P-type atpase
IRJ22_RS12885	COG2608	mercury ion transmembrane transporter activity
IRJ22_RS12890	COG1937	Protein conserved in bacteria
IRJ22_RS12895	COG0693	protein deglycase activity
IRJ22_RS12900	COG1349	DNA-binding transcription factor activity
IRJ22_RS12905	COG1070	Carbohydrate kinase
IRJ22_RS12910	COG4952	isomerase
IRJ22_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS12920	COG3347	Dehydrogenase
IRJ22_RS12925	COG2814	Major facilitator Superfamily
IRJ22_RS12930	COG2814	Major facilitator Superfamily
IRJ22_RS12940	COG2124	cytochrome p450
IRJ22_RS12950	COG1846	Transcriptional regulator
IRJ22_RS12960	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS12965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IRJ22_RS12970	COG1054	Belongs to the UPF0176 family
IRJ22_RS12980	COG1191	sigma factor activity
IRJ22_RS12990	COG2140	Oxalate decarboxylase
IRJ22_RS13035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRJ22_RS13065	COG5444	nuclease activity
IRJ22_RS13105	COG5434	Belongs to the glycosyl hydrolase 28 family
IRJ22_RS13110	COG1705	Flagellar rod assembly protein muramidase FlgJ
IRJ22_RS13120	COG5280	Phage tail tape measure protein TP901
IRJ22_RS13120	COG3953	SLT domain
IRJ22_RS13180	COG1802	Transcriptional regulator
IRJ22_RS13180	COG4626	Terminase
IRJ22_RS13330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IRJ22_RS13335	COG0557	exoribonuclease II activity
IRJ22_RS13340	COG1647	Serine aminopeptidase, S33
IRJ22_RS13345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IRJ22_RS13350	COG2002	toxin-antitoxin pair type II binding
IRJ22_RS13355	COG1476	TRANSCRIPTIONal
IRJ22_RS13360	COG1396	sequence-specific DNA binding
IRJ22_RS13365	COG1396	sequence-specific DNA binding
IRJ22_RS13370	COG1174	glycine betaine transport
IRJ22_RS13375	COG1732	Glycine betaine
IRJ22_RS13380	COG1174	glycine betaine transport
IRJ22_RS13385	COG1125	glycine betaine transport
IRJ22_RS13385	COG0517	IMP dehydrogenase activity
IRJ22_RS13390	COG1510	regulation of RNA biosynthetic process
IRJ22_RS13395	COG2095	MarC family integral membrane protein
IRJ22_RS13400	COG3064	Membrane
IRJ22_RS13405	COG4640	response to antibiotic
IRJ22_RS13415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS13430	COG0148	phosphopyruvate hydratase activity
IRJ22_RS13435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IRJ22_RS13440	COG0149	triose-phosphate isomerase activity
IRJ22_RS13445	COG0126	phosphoglycerate kinase activity
IRJ22_RS13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IRJ22_RS13455	COG2390	Transcriptional regulator
IRJ22_RS13460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRJ22_RS13465	COG1113	amino acid transport
IRJ22_RS13485	COG1556	Lactate utilization protein
IRJ22_RS13490	COG1139	Iron-sulfur cluster binding protein
IRJ22_RS13495	COG0247	lactate metabolic process
IRJ22_RS13500	COG2186	Transcriptional regulator
IRJ22_RS13505	COG1620	l-lactate permease
IRJ22_RS13510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IRJ22_RS13520	COG5039	Polysaccharide pyruvyl transferase
IRJ22_RS13525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IRJ22_RS13530	COG0110	maltose O-acetyltransferase activity
IRJ22_RS13535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IRJ22_RS13540	COG2244	polysaccharide biosynthetic process
IRJ22_RS13545	COG1216	Glycosyl transferase, family 2
IRJ22_RS13550	COG5039	Polysaccharide pyruvyl transferase
IRJ22_RS13555	COG1216	Glycosyl transferase, family 2
IRJ22_RS13565	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS13570	COG1215	transferase activity, transferring glycosyl groups
IRJ22_RS13575	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS13580	COG1086	Polysaccharide biosynthesis protein
IRJ22_RS13585	COG0489	protein tyrosine kinase activity
IRJ22_RS13590	COG3944	biosynthesis protein
IRJ22_RS13595	COG1396	sequence-specific DNA binding
IRJ22_RS13605	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS13610	COG2271	Major facilitator Superfamily
IRJ22_RS13620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IRJ22_RS13635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRJ22_RS13645	COG1733	regulation of RNA biosynthetic process
IRJ22_RS13650	COG1902	pentaerythritol trinitrate reductase activity
IRJ22_RS13655	COG1621	beta-fructofuranosidase activity
IRJ22_RS13660	COG1621	beta-fructofuranosidase activity
IRJ22_RS13675	COG0740	serine-type endopeptidase activity
IRJ22_RS13680	COG1611	Belongs to the LOG family
IRJ22_RS13685	COG1694	Mazg nucleotide pyrophosphohydrolase
IRJ22_RS13690	COG1078	dGTPase activity
IRJ22_RS13695	COG0659	secondary active sulfate transmembrane transporter activity
IRJ22_RS13700	COG0288	reversible hydration of carbon dioxide
IRJ22_RS13705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRJ22_RS13710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IRJ22_RS13715	COG0640	Transcriptional regulator
IRJ22_RS13725	COG2732	(Barnase) inhibitor
IRJ22_RS13730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IRJ22_RS13735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS13740	COG1481	regulation of sporulation
IRJ22_RS13745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IRJ22_RS13750	COG1660	Displays ATPase and GTPase activities
IRJ22_RS13755	COG1051	belongs to the nudix hydrolase family
IRJ22_RS13760	COG0492	ferredoxin-NADP+ reductase activity
IRJ22_RS13765	COG0457	Tetratricopeptide repeat
IRJ22_RS13775	COG0140	phosphoribosyl-ATP diphosphatase activity
IRJ22_RS13775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IRJ22_RS13780	COG0107	imidazoleglycerol-phosphate synthase activity
IRJ22_RS13785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IRJ22_RS13790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IRJ22_RS13795	COG0131	Imidazoleglycerol-phosphate dehydratase
IRJ22_RS13800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IRJ22_RS13805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IRJ22_RS13810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IRJ22_RS13815	COG4990	cell redox homeostasis
IRJ22_RS13820	COG5297	Belongs to the glycosyl hydrolase family 6
IRJ22_RS13825	COG0110	maltose O-acetyltransferase activity
IRJ22_RS13830	COG0546	phosphoglycolate phosphatase activity
IRJ22_RS13835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRJ22_RS13840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IRJ22_RS13845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IRJ22_RS13850	COG1846	Transcriptional regulator
IRJ22_RS13855	COG2814	Major facilitator Superfamily
IRJ22_RS13860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IRJ22_RS13865	COG1950	PFAM Membrane protein of
IRJ22_RS13870	COG1983	PspC domain protein
IRJ22_RS13875	COG3595	metallopeptidase activity
IRJ22_RS13895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IRJ22_RS13900	COG0556	nucleotide-excision repair
IRJ22_RS13905	COG4897	Protein conserved in bacteria
IRJ22_RS13915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRJ22_RS13925	COG0793	Belongs to the peptidase S41A family
IRJ22_RS13925	COG3409	Peptidoglycan-binding domain 1 protein
IRJ22_RS13930	COG0473	3-isopropylmalate dehydrogenase activity
IRJ22_RS13935	COG0791	NLP P60 protein
IRJ22_RS13935	COG3883	PFAM NLP P60 protein
IRJ22_RS13940	COG2177	Part of the ABC transporter FtsEX involved in
IRJ22_RS13945	COG2884	Cell division ATP-binding protein ftsE
IRJ22_RS13950	COG2010	Cytochrome c
IRJ22_RS13955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS13965	COG0653	protein targeting
IRJ22_RS13970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IRJ22_RS13985	COG1516	flagellar protein fliS
IRJ22_RS13990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IRJ22_RS13995	COG1334	flagellar protein FlaG
IRJ22_RS14000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRJ22_RS14005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IRJ22_RS14010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IRJ22_RS14020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRJ22_RS14025	COG1256	bacterial-type flagellum assembly
IRJ22_RS14025	COG4786	Flagellar basal body rod
IRJ22_RS14030	COG3418	PFAM FlgN family protein
IRJ22_RS14035	COG2747	anti-sigma28 factor FlgM
IRJ22_RS14045	COG1040	competence protein
IRJ22_RS14055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IRJ22_RS14060	COG1307	EDD domain protein, DegV family
IRJ22_RS14065	COG2197	response regulator
IRJ22_RS14070	COG4585	Histidine kinase
IRJ22_RS14075	COG1739	Uncharacterized protein family UPF0029
IRJ22_RS14080	COG1316	TRANSCRIPTIONal
IRJ22_RS14090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRJ22_RS14095	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS14100	COG1215	transferase activity, transferring glycosyl groups
IRJ22_RS14105	COG3206	protein involved in exopolysaccharide biosynthesis
IRJ22_RS14110	COG3307	-O-antigen
IRJ22_RS14115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRJ22_RS14120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IRJ22_RS14125	COG0297	glycogen (starch) synthase activity
IRJ22_RS14125	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS14130	COG2244	polysaccharide biosynthetic process
IRJ22_RS14140	COG2247	cell wall binding repeat
IRJ22_RS14140	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS14145	COG2247	cell wall binding repeat
IRJ22_RS14145	COG2385	sporulation resulting in formation of a cellular spore
IRJ22_RS14155	COG1316	TRANSCRIPTIONal
IRJ22_RS14160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IRJ22_RS14165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRJ22_RS14170	COG1134	teichoic acid transport
IRJ22_RS14175	COG1682	transport, permease protein
IRJ22_RS14180	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS14190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IRJ22_RS14210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IRJ22_RS14210	COG0463	Glycosyl transferase, family 2
IRJ22_RS14215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IRJ22_RS14220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IRJ22_RS14225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IRJ22_RS14230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IRJ22_RS14235	COG4193	domain, Protein
IRJ22_RS14240	COG1482	cell wall glycoprotein biosynthetic process
IRJ22_RS14260	COG0800	Aldolase
IRJ22_RS14265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRJ22_RS14270	COG1609	Transcriptional regulator
IRJ22_RS14275	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IRJ22_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS14285	COG1063	alcohol dehydrogenase
IRJ22_RS14300	COG1316	TRANSCRIPTIONal
IRJ22_RS14305	COG0561	phosphatase activity
IRJ22_RS14310	COG0791	NLP P60 protein
IRJ22_RS14320	COG2843	Capsule synthesis protein
IRJ22_RS14330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IRJ22_RS14335	COG1609	Transcriptional regulator
IRJ22_RS14340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRJ22_RS14345	COG1869	D-ribose catabolic process
IRJ22_RS14350	COG1129	ABC transporter
IRJ22_RS14355	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRJ22_RS14360	COG1879	ABC-type sugar transport system periplasmic component
IRJ22_RS14365	COG3527	Alpha-acetolactate decarboxylase
IRJ22_RS14370	COG0028	Belongs to the TPP enzyme family
IRJ22_RS14375	COG0583	DNA-binding transcription factor activity
IRJ22_RS14380	COG0405	Gamma-glutamyltransferase
IRJ22_RS14385	COG1522	sequence-specific DNA binding
IRJ22_RS14390	COG2059	Chromate
IRJ22_RS14395	COG2059	Chromate
IRJ22_RS14400	COG4464	protein tyrosine phosphatase activity
IRJ22_RS14405	COG3944	biosynthesis protein
IRJ22_RS14415	COG4715	Zinc finger, swim domain protein
IRJ22_RS14420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRJ22_RS14430	COG0561	phosphatase activity
IRJ22_RS14435	COG1349	DNA-binding transcription factor activity
IRJ22_RS14445	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS14455	COG3732	PTS system glucitol sorbitol-specific
IRJ22_RS14475	COG0629	single-stranded DNA binding
IRJ22_RS14490	COG1970	mechanosensitive ion channel activity
IRJ22_RS14495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IRJ22_RS14500	COG4786	Flagellar basal body rod
IRJ22_RS14505	COG4786	Flagellar basal body rod
IRJ22_RS14510	COG1077	Cell shape determining protein MreB Mrl
IRJ22_RS14515	COG1609	Transcriptional regulator
IRJ22_RS14520	COG1846	Transcriptional regulator
IRJ22_RS14525	COG2814	Major facilitator Superfamily
IRJ22_RS14530	COG0671	phosphoesterase, PA-phosphatase related
IRJ22_RS14535	COG1227	inorganic diphosphatase activity
IRJ22_RS14540	COG3546	catalase activity
IRJ22_RS14545	COG3361	conserved protein (COG2071)
IRJ22_RS14550	COG0517	IMP dehydrogenase activity
IRJ22_RS14555	COG0598	Magnesium transport protein CorA
IRJ22_RS14560	COG1253	flavin adenine dinucleotide binding
IRJ22_RS14565	COG0004	ammonium transporteR
IRJ22_RS14570	COG0347	Belongs to the P(II) protein family
IRJ22_RS14575	COG0740	serine-type endopeptidase activity
IRJ22_RS14585	COG0739	heme binding
IRJ22_RS14590	COG1247	-acetyltransferase
IRJ22_RS14600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IRJ22_RS14605	COG0477	Major facilitator Superfamily
IRJ22_RS14610	COG3251	PFAM MbtH domain protein
IRJ22_RS14615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRJ22_RS14620	COG1535	isochorismatase
IRJ22_RS14620	COG3433	isochorismatase activity
IRJ22_RS14625	COG1021	2,3-dihydroxybenzoate-AMP ligase
IRJ22_RS14630	COG1169	isochorismate synthase
IRJ22_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS14640	COG2819	hydrolase of the alpha beta superfamily
IRJ22_RS14645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS14650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS14655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS14660	COG2207	Transcriptional regulator
IRJ22_RS14660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS14670	COG2910	NAD(P)H-binding
IRJ22_RS14675	COG1959	2 iron, 2 sulfur cluster binding
IRJ22_RS14685	COG1994	Peptidase M50
IRJ22_RS14690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRJ22_RS14695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IRJ22_RS14700	COG2223	nitrite transmembrane transporter activity
IRJ22_RS14705	COG3383	formate dehydrogenase (NAD+) activity
IRJ22_RS14710	COG2304	oxidoreductase activity
IRJ22_RS14715	COG2304	oxidoreductase activity
IRJ22_RS14720	COG2385	sporulation resulting in formation of a cellular spore
IRJ22_RS14725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRJ22_RS14735	COG4836	Membrane
IRJ22_RS14740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IRJ22_RS14745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IRJ22_RS14750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IRJ22_RS14755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IRJ22_RS14760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRJ22_RS14765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IRJ22_RS14770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRJ22_RS14785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IRJ22_RS14790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IRJ22_RS14795	COG4475	Protein of unknown function (DUF436)
IRJ22_RS14800	COG0698	ribose 5-phosphate isomerase
IRJ22_RS14805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRJ22_RS14810	COG1971	Probably functions as a manganese efflux pump
IRJ22_RS14815	COG0009	L-threonylcarbamoyladenylate synthase
IRJ22_RS14820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IRJ22_RS14830	COG0738	Major facilitator superfamily
IRJ22_RS14840	COG0561	phosphatase activity
IRJ22_RS14845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IRJ22_RS14850	COG1609	Transcriptional regulator
IRJ22_RS14855	COG2890	protein-(glutamine-N5) methyltransferase activity
IRJ22_RS14860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IRJ22_RS14865	COG0346	lactoylglutathione lyase activity
IRJ22_RS14870	COG0789	Transcriptional regulator
IRJ22_RS14875	COG0679	Auxin Efflux Carrier
IRJ22_RS14880	COG0281	malic enzyme
IRJ22_RS14885	COG1435	thymidine kinase activity
IRJ22_RS14890	COG0254	rRNA binding
IRJ22_RS14895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IRJ22_RS14900	COG1494	fructose-1,6-bisphosphatase
IRJ22_RS14905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRJ22_RS14910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IRJ22_RS14915	COG0191	fructose-bisphosphate aldolase activity
IRJ22_RS14920	COG2204	response regulator
IRJ22_RS14925	COG4821	SIS domain
IRJ22_RS14930	COG0504	CTP synthase activity
IRJ22_RS14935	COG3343	RNA polymerase activity
IRJ22_RS14945	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS14950	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS14955	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRJ22_RS14960	COG0183	Belongs to the thiolase family
IRJ22_RS14965	COG0247	lactate metabolic process
IRJ22_RS14965	COG2181	nitrate reductase activity
IRJ22_RS14970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IRJ22_RS14980	COG0018	arginyl-trna synthetase
IRJ22_RS14985	COG4506	Protein conserved in bacteria
IRJ22_RS14990	COG0010	Belongs to the arginase family
IRJ22_RS14995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRJ22_RS15010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRJ22_RS15020	COG1994	Peptidase M50
IRJ22_RS15025	COG1942	4-Oxalocrotonate Tautomerase
IRJ22_RS15035	COG3465	dGTPase activity
IRJ22_RS15040	COG1078	dGTPase activity
IRJ22_RS15045	COG4844	belongs to the
IRJ22_RS15070	COG2814	Major facilitator Superfamily
IRJ22_RS15095	COG1414	Transcriptional regulator
IRJ22_RS15105	COG0280	phosphate acetyltransferase
IRJ22_RS15110	COG3253	May function as heme-dependent peroxidase
IRJ22_RS15120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IRJ22_RS15140	COG1131	(ABC) transporter
IRJ22_RS15155	COG2363	Small membrane protein
IRJ22_RS15160	COG2233	PERMEase
IRJ22_RS15170	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS15175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IRJ22_RS15180	COG1216	Glycosyl transferase, family 2
IRJ22_RS15185	COG0351	phosphomethylpyrimidine kinase
IRJ22_RS15195	COG1621	beta-fructofuranosidase activity
IRJ22_RS15200	COG1263	PTS System
IRJ22_RS15200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS15205	COG3711	transcriptional antiterminator
IRJ22_RS15215	COG1404	Belongs to the peptidase S8 family
IRJ22_RS15225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRJ22_RS15230	COG0778	Nitroreductase
IRJ22_RS15240	COG0772	Belongs to the SEDS family
IRJ22_RS15245	COG0772	Belongs to the SEDS family
IRJ22_RS15250	COG3314	Sporulation integral membrane protein YlbJ
IRJ22_RS15265	COG0456	acetyltransferase
IRJ22_RS15300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IRJ22_RS15310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRJ22_RS15315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRJ22_RS15320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRJ22_RS15335	COG3162	membrane
IRJ22_RS15340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS15350	COG2115	Belongs to the xylose isomerase family
IRJ22_RS15360	COG0352	thiamine-phosphate diphosphorylase activity
IRJ22_RS15365	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IRJ22_RS15370	COG0583	DNA-binding transcription factor activity
IRJ22_RS15385	COG1380	Effector of murein hydrolase LrgA
IRJ22_RS15390	COG1346	cytolysis
IRJ22_RS15400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS15405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IRJ22_RS15410	COG0346	lactoylglutathione lyase activity
IRJ22_RS15415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRJ22_RS15420	COG1442	glycosyl transferase family 8
IRJ22_RS15435	COG4585	Histidine kinase
IRJ22_RS15440	COG2197	response regulator
IRJ22_RS15445	COG2409	Drug exporters of the RND superfamily
IRJ22_RS15450	COG5522	Integral membrane protein (intg_mem_TP0381)
IRJ22_RS15455	COG2271	Major facilitator Superfamily
IRJ22_RS15460	COG4948	Mandelate Racemase Muconate Lactonizing
IRJ22_RS15465	COG0800	Aldolase
IRJ22_RS15470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRJ22_RS15480	COG2234	aminopeptidase activity
IRJ22_RS15485	COG0477	Major facilitator Superfamily
IRJ22_RS15495	COG2357	RelA SpoT domain protein
IRJ22_RS15510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRJ22_RS15515	COG1696	Membrane protein involved in D-alanine export
IRJ22_RS15520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRJ22_RS15525	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IRJ22_RS15530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRJ22_RS15535	COG2814	Major facilitator Superfamily
IRJ22_RS15540	COG1486	melibiose metabolic process
IRJ22_RS15545	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRJ22_RS15550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS15555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS15560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS15560	COG3711	transcriptional antiterminator
IRJ22_RS15570	COG2094	Belongs to the DNA glycosylase MPG family
IRJ22_RS15580	COG0372	Belongs to the citrate synthase family
IRJ22_RS15585	COG2079	MmgE PrpD family protein
IRJ22_RS15590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IRJ22_RS15605	COG1132	(ABC) transporter
IRJ22_RS15610	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS15625	COG2814	Major facilitator Superfamily
IRJ22_RS15630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRJ22_RS15635	COG1131	(ABC) transporter
IRJ22_RS15655	COG1595	DNA-templated transcription, initiation
IRJ22_RS15660	COG2814	Major facilitator Superfamily
IRJ22_RS15665	COG0753	catalase activity
IRJ22_RS15670	COG0753	catalase activity
IRJ22_RS15675	COG0735	belongs to the Fur family
IRJ22_RS15680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IRJ22_RS15685	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRJ22_RS15690	COG1131	(ABC) transporter
IRJ22_RS15705	COG1131	(ABC) transporter
IRJ22_RS15760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IRJ22_RS15765	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IRJ22_RS15770	COG4988	ABC transporter
IRJ22_RS15775	COG1294	oxidase, subunit
IRJ22_RS15780	COG1271	oxidase subunit
IRJ22_RS15785	COG2116	formate transmembrane transporter activity
IRJ22_RS15795	COG0281	malic enzyme
IRJ22_RS15800	COG1757	Na H antiporter
IRJ22_RS15805	COG1027	Aspartate ammonia-lyase
IRJ22_RS15810	COG0252	asparaginase activity
IRJ22_RS15815	COG1396	sequence-specific DNA binding
IRJ22_RS15820	COG2706	6-phosphogluconolactonase activity
IRJ22_RS15830	COG2205	protein histidine kinase activity
IRJ22_RS15835	COG1136	(ABC) transporter
IRJ22_RS15845	COG5294	Protein conserved in bacteria
IRJ22_RS15860	COG0726	polysaccharide deacetylase
IRJ22_RS15865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRJ22_RS15870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRJ22_RS15875	COG1215	transferase activity, transferring glycosyl groups
IRJ22_RS15880	COG3493	citrate carrier protein
IRJ22_RS15885	COG0584	glycerophosphoryl diester phosphodiesterase
IRJ22_RS15900	COG1368	sulfuric ester hydrolase activity
IRJ22_RS15910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS15920	COG2235	arginine
IRJ22_RS15925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IRJ22_RS15935	COG0549	Belongs to the carbamate kinase family
IRJ22_RS15945	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS15950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS15960	COG1595	DNA-templated transcription, initiation
IRJ22_RS15985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRJ22_RS15990	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRJ22_RS15995	COG1621	beta-fructofuranosidase activity
IRJ22_RS16000	COG2223	nitrite transmembrane transporter activity
IRJ22_RS16005	COG0395	ABC-type sugar transport system, permease component
IRJ22_RS16010	COG1175	transmembrane transport
IRJ22_RS16020	COG1609	Transcriptional regulator
IRJ22_RS16035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IRJ22_RS16040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IRJ22_RS16045	COG0463	Glycosyl transferase, family 2
IRJ22_RS16050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRJ22_RS16075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IRJ22_RS16090	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS16095	COG1263	PTS System
IRJ22_RS16095	COG2190	(PTS) system
IRJ22_RS16095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS16100	COG3711	transcriptional antiterminator
IRJ22_RS16105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRJ22_RS16110	COG1122	ATPase activity
IRJ22_RS16115	COG4721	ABC-type cobalt transport system, permease component
IRJ22_RS16120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRJ22_RS16130	COG2224	Isocitrate lyase
IRJ22_RS16135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IRJ22_RS16145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IRJ22_RS16150	COG0577	efflux transmembrane transporter activity
IRJ22_RS16155	COG1136	(ABC) transporter
IRJ22_RS16160	COG2205	protein histidine kinase activity
IRJ22_RS16165	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS16170	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS16175	COG1263	PTS System
IRJ22_RS16175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS16175	COG2190	(PTS) system
IRJ22_RS16185	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
IRJ22_RS16195	COG3507	Belongs to the glycosyl hydrolase 43 family
IRJ22_RS16200	COG0513	Belongs to the DEAD box helicase family
IRJ22_RS16230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IRJ22_RS16235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IRJ22_RS16240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRJ22_RS16245	COG2390	Transcriptional regulator
IRJ22_RS16255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IRJ22_RS16260	COG3706	GGDEF domain
IRJ22_RS16265	COG5298	Protein conserved in bacteria
IRJ22_RS16280	COG3977	Valine--pyruvate aminotransferase
IRJ22_RS16295	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRJ22_RS16305	COG0191	fructose-bisphosphate aldolase activity
IRJ22_RS16310	COG1082	Xylose isomerase domain protein TIM barrel
IRJ22_RS16315	COG1082	Xylose isomerase domain protein TIM barrel
IRJ22_RS16320	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS16325	COG2814	Major facilitator Superfamily
IRJ22_RS16330	COG1082	Xylose isomerase domain protein TIM barrel
IRJ22_RS16335	COG3962	Belongs to the TPP enzyme family
IRJ22_RS16340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRJ22_RS16345	COG3718	enzyme involved in inositol metabolism
IRJ22_RS16350	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS16355	COG1349	DNA-binding transcription factor activity
IRJ22_RS16360	COG0667	Aldo Keto reductase
IRJ22_RS16365	COG0584	glycerophosphoryl diester phosphodiesterase
IRJ22_RS16370	COG2271	Major facilitator Superfamily
IRJ22_RS16375	COG0326	Molecular chaperone. Has ATPase activity
IRJ22_RS16380	COG0488	(ABC) transporter
IRJ22_RS16385	COG0561	phosphatase activity
IRJ22_RS16405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRJ22_RS16435	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
IRJ22_RS16440	COG0577	efflux transmembrane transporter activity
IRJ22_RS16445	COG1136	(ABC) transporter
IRJ22_RS16450	COG2205	protein histidine kinase activity
IRJ22_RS16455	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS16465	COG5278	phosphoserine phosphatase activity
IRJ22_RS16465	COG0840	transmembrane signaling receptor activity
IRJ22_RS16470	COG1115	amino acid carrier protein
IRJ22_RS16475	COG0686	Belongs to the AlaDH PNT family
IRJ22_RS16480	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IRJ22_RS16485	COG1874	Beta-galactosidase
IRJ22_RS16490	COG3833	ABC-type maltose transport systems, permease component
IRJ22_RS16495	COG1175	transmembrane transport
IRJ22_RS16500	COG2182	Extracellular solute-binding protein
IRJ22_RS16505	COG1609	Transcriptional regulator
IRJ22_RS16520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IRJ22_RS16525	COG1940	carbohydrate kinase activity
IRJ22_RS16550	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS16550	COG1454	alcohol dehydrogenase
IRJ22_RS16555	COG0450	alkyl hydroperoxide reductase
IRJ22_RS16560	COG3634	alkyl hydroperoxide reductase activity
IRJ22_RS16585	COG1131	(ABC) transporter
IRJ22_RS16595	COG4585	Histidine kinase
IRJ22_RS16600	COG2197	response regulator
IRJ22_RS16630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IRJ22_RS16645	COG0456	acetyltransferase
IRJ22_RS16660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRJ22_RS16665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IRJ22_RS16670	COG4853	Protein conserved in bacteria
IRJ22_RS16675	COG4863	YycH protein
IRJ22_RS16680	COG5002	protein histidine kinase activity
IRJ22_RS16685	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS16710	COG1051	belongs to the nudix hydrolase family
IRJ22_RS16715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IRJ22_RS16725	COG0305	Participates in initiation and elongation during chromosome replication
IRJ22_RS16740	COG3093	addiction module antidote protein HigA
IRJ22_RS16745	COG2807	transmembrane transport
IRJ22_RS16750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IRJ22_RS16755	COG0363	glucosamine-6-phosphate deaminase activity
IRJ22_RS16760	COG2188	Transcriptional regulator
IRJ22_RS16765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IRJ22_RS16770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS16770	COG1263	PTS System
IRJ22_RS16775	COG0359	binds to the 23S rRNA
IRJ22_RS16780	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IRJ22_RS16785	COG4241	membrane
IRJ22_RS16795	COG5577	PFAM Coat F domain
IRJ22_RS16800	COG0589	response to stress
IRJ22_RS16805	COG0659	secondary active sulfate transmembrane transporter activity
IRJ22_RS16810	COG2271	Major facilitator Superfamily
IRJ22_RS16815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IRJ22_RS16820	COG0629	single-stranded DNA binding
IRJ22_RS16825	COG0360	Binds together with S18 to 16S ribosomal RNA
IRJ22_RS16830	COG0012	GTP binding
IRJ22_RS16835	COG4481	Protein conserved in bacteria
IRJ22_RS16840	COG3949	Membrane
IRJ22_RS16850	COG1475	DNA binding
IRJ22_RS16855	COG1192	Involved in chromosome partitioning
IRJ22_RS16860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IRJ22_RS16870	COG1475	DNA binding
IRJ22_RS16875	COG0357	Ribosomal RNA small subunit methyltransferase G
IRJ22_RS16880	COG0445	tRNA wobble uridine modification
IRJ22_RS16885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IRJ22_RS16890	COG1847	R3H domain protein
IRJ22_RS16895	COG0706	membrane insertase activity
IRJ22_RS16900	COG0594	ribonuclease P activity
IRJ22_RS16910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IRJ22_RS16915	COG0592	DNA-directed DNA polymerase activity
IRJ22_RS16920	COG2501	S4 domain
IRJ22_RS16925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IRJ22_RS16935	COG0187	DNA topoisomerase II activity
IRJ22_RS16940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRJ22_RS16975	COG0517	IMP dehydrogenase activity
IRJ22_RS16975	COG0516	GMP reductase activity
IRJ22_RS16980	COG1686	Belongs to the peptidase S11 family
IRJ22_RS16985	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IRJ22_RS16990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IRJ22_RS16995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IRJ22_RS17000	COG1929	Belongs to the glycerate kinase type-1 family
IRJ22_RS17005	COG2610	gluconate transmembrane transporter activity
IRJ22_RS17010	COG3835	regulator
IRJ22_RS17025	COG1428	Deoxynucleoside kinase
IRJ22_RS17030	COG1428	Deoxynucleoside kinase
IRJ22_RS17035	COG1388	LysM domain
IRJ22_RS17035	COG3858	chitin binding
IRJ22_RS17040	COG1335	isochorismatase
IRJ22_RS17045	COG0590	tRNA wobble adenosine to inosine editing
IRJ22_RS17055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IRJ22_RS17060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IRJ22_RS17065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IRJ22_RS17110	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IRJ22_RS17115	COG3853	Toxic anion resistance protein (TelA)
IRJ22_RS17120	COG1982	Orn Lys Arg decarboxylase major
IRJ22_RS17125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IRJ22_RS17130	COG3870	Protein conserved in bacteria
IRJ22_RS17135	COG1728	Protein conserved in bacteria
IRJ22_RS17140	COG0470	DNA polymerase III
IRJ22_RS17145	COG1774	PSP1 C-terminal conserved region
IRJ22_RS17150	COG4467	Involved in initiation control of chromosome replication
IRJ22_RS17155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IRJ22_RS17160	COG2827	Endonuclease containing a URI domain
IRJ22_RS17165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IRJ22_RS17170	COG2002	toxin-antitoxin pair type II binding
IRJ22_RS17175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRJ22_RS17175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRJ22_RS17180	COG0084	hydrolase, TatD family'
IRJ22_RS17185	COG3583	domain protein
IRJ22_RS17185	COG3584	3D domain protein
IRJ22_RS17190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IRJ22_RS17195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRJ22_RS17205	COG4466	Protein conserved in bacteria
IRJ22_RS17215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IRJ22_RS17220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRJ22_RS17225	COG0251	oxidation-reduction process
IRJ22_RS17230	COG2088	sporulation resulting in formation of a cellular spore
IRJ22_RS17235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRJ22_RS17240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRJ22_RS17245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IRJ22_RS17250	COG0193	aminoacyl-tRNA hydrolase activity
IRJ22_RS17260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IRJ22_RS17265	COG2002	toxin-antitoxin pair type II binding
IRJ22_RS17270	COG2244	polysaccharide biosynthetic process
IRJ22_RS17275	COG3956	TIGRFAM MazG family protein
IRJ22_RS17280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IRJ22_RS17295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IRJ22_RS17300	COG1098	S1 RNA binding domain
IRJ22_RS17315	COG2208	phosphoserine phosphatase activity
IRJ22_RS17320	COG2304	oxidoreductase activity
IRJ22_RS17325	COG0515	serine threonine protein kinase
IRJ22_RS17330	COG0037	tRNA processing
IRJ22_RS17335	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IRJ22_RS17340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRJ22_RS17345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IRJ22_RS17350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IRJ22_RS17355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRJ22_RS17360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRJ22_RS17365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRJ22_RS17370	COG0512	Glutamine amidotransferase of anthranilate synthase
IRJ22_RS17375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRJ22_RS17380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRJ22_RS17385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IRJ22_RS17390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IRJ22_RS17395	COG1396	sequence-specific DNA binding
IRJ22_RS17400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IRJ22_RS17405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IRJ22_RS17485	COG4463	regulation of RNA biosynthetic process
IRJ22_RS17490	COG3880	PFAM UvrB UvrC protein
IRJ22_RS17495	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IRJ22_RS17500	COG0542	response to heat
IRJ22_RS17505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IRJ22_RS17510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IRJ22_RS17515	COG4956	integral membrane protein (PIN domain superfamily)
IRJ22_RS17520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IRJ22_RS17525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IRJ22_RS17530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRJ22_RS17535	COG1045	serine acetyltransferase
IRJ22_RS17540	COG0215	cysteine-tRNA ligase activity
IRJ22_RS17550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRJ22_RS17555	COG3688	RNA-binding protein containing a PIN domain
IRJ22_RS17565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRJ22_RS17575	COG0250	Participates in transcription elongation, termination and antitermination
IRJ22_RS17580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IRJ22_RS17585	COG0081	regulation of translation
IRJ22_RS17590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IRJ22_RS17595	COG0222	ribosome binding
IRJ22_RS17600	COG2813	Specifically methylates the guanine in position
IRJ22_RS17605	COG0085	RNA polymerase activity
IRJ22_RS17610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IRJ22_RS17615	COG1358	cellular component organization or biogenesis
IRJ22_RS17620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IRJ22_RS17625	COG0049	tRNA binding
IRJ22_RS17630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IRJ22_RS17635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IRJ22_RS17645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IRJ22_RS17650	COG0088	Forms part of the polypeptide exit tunnel
IRJ22_RS17655	COG0089	rRNA binding
IRJ22_RS17660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IRJ22_RS17665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IRJ22_RS17670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IRJ22_RS17675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IRJ22_RS17680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IRJ22_RS17685	COG0255	Belongs to the universal ribosomal protein uL29 family
IRJ22_RS17690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IRJ22_RS17695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IRJ22_RS17700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IRJ22_RS17705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IRJ22_RS17710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRJ22_RS17715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IRJ22_RS17720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IRJ22_RS17725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IRJ22_RS17730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IRJ22_RS17735	COG1841	ribosomal large subunit assembly
IRJ22_RS17740	COG0200	Binds to the 23S rRNA
IRJ22_RS17745	COG0201	protein transport
IRJ22_RS17750	COG0563	adenylate kinase activity
IRJ22_RS17755	COG0024	Methionine aminopeptidase
IRJ22_RS17760	COG2163	COG2163 Ribosomal protein L14E L6E L27E
IRJ22_RS17765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRJ22_RS17770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IRJ22_RS17775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IRJ22_RS17780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IRJ22_RS17785	COG0202	RNA polymerase activity
IRJ22_RS17790	COG0203	ribosomal protein L17
IRJ22_RS17795	COG1122	ATPase activity
IRJ22_RS17800	COG1122	ATPase activity
IRJ22_RS17805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRJ22_RS17810	COG0101	tRNA pseudouridine synthase activity
IRJ22_RS17815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IRJ22_RS17820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IRJ22_RS17825	COG2318	DinB family
IRJ22_RS17835	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS17840	COG0489	protein tyrosine kinase activity
IRJ22_RS17850	COG2194	sulfuric ester hydrolase activity
IRJ22_RS17855	COG0726	polysaccharide deacetylase
IRJ22_RS17885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRJ22_RS17895	COG0385	Bile acid
IRJ22_RS17910	COG3876	Protein conserved in bacteria
IRJ22_RS17915	COG1472	Belongs to the glycosyl hydrolase 3 family
IRJ22_RS17920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRJ22_RS17925	COG1263	PTS System
IRJ22_RS17925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS17930	COG1737	Transcriptional regulator
IRJ22_RS17935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IRJ22_RS17940	COG1683	Conserved Protein
IRJ22_RS17975	COG1595	DNA-templated transcription, initiation
IRJ22_RS17980	COG5662	AntiSigma factor
IRJ22_RS17985	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRJ22_RS17990	COG4856	YbbR-like protein
IRJ22_RS17995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRJ22_RS18000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRJ22_RS18020	COG1725	Transcriptional regulator
IRJ22_RS18025	COG0640	Transcriptional regulator
IRJ22_RS18030	COG2814	Major facilitator Superfamily
IRJ22_RS18040	COG1132	(ABC) transporter
IRJ22_RS18045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IRJ22_RS18070	COG1011	Hydrolase
IRJ22_RS18075	COG1113	amino acid transport
IRJ22_RS18080	COG2851	Citrate transporter
IRJ22_RS18085	COG3181	Tripartite tricarboxylate transporter family receptor
IRJ22_RS18090	COG4565	transcriptional regulatory protein
IRJ22_RS18105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRJ22_RS18110	COG2211	Major facilitator Superfamily
IRJ22_RS18130	COG1331	Highly conserved protein containing a thioredoxin domain
IRJ22_RS18135	COG1331	Highly conserved protein containing a thioredoxin domain
IRJ22_RS18140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRJ22_RS18175	COG1331	Highly conserved protein containing a thioredoxin domain
IRJ22_RS18185	COG0477	Major facilitator Superfamily
IRJ22_RS18205	COG1283	sodium-dependent phosphate transmembrane transporter activity
IRJ22_RS18210	COG4682	membrane
IRJ22_RS18230	COG0697	spore germination
IRJ22_RS18255	COG0371	Dehydrogenase
IRJ22_RS18260	COG0840	transmembrane signaling receptor activity
IRJ22_RS18265	COG4213	ABC transporter substrate-binding protein
IRJ22_RS18280	COG4257	antibiotic catabolic process
IRJ22_RS18290	COG0833	amino acid
IRJ22_RS18295	COG2040	homocysteine
IRJ22_RS18305	COG1263	PTS System
IRJ22_RS18305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS18305	COG2190	(PTS) system
IRJ22_RS18310	COG0789	Transcriptional regulator
IRJ22_RS18315	COG2323	membrane
IRJ22_RS18320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IRJ22_RS18320	COG4451	ribulose bisphosphate carboxylase, small
IRJ22_RS18325	COG2205	protein histidine kinase activity
IRJ22_RS18330	COG1115	amino acid carrier protein
IRJ22_RS18335	COG2066	Belongs to the glutaminase family
IRJ22_RS18345	COG4191	Histidine kinase
IRJ22_RS18350	COG0784	Response regulator, receiver
IRJ22_RS18375	COG3540	Alkaline phosphatase
IRJ22_RS18380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRJ22_RS18385	COG0805	protein transport
IRJ22_RS18390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRJ22_RS18395	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS18400	COG2271	Major facilitator Superfamily
IRJ22_RS18405	COG4948	Mandelate Racemase Muconate Lactonizing
IRJ22_RS18410	COG2186	Transcriptional regulator
IRJ22_RS18415	COG2721	sulfolactate sulfo-lyase activity
IRJ22_RS18420	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS18425	COG2205	protein histidine kinase activity
IRJ22_RS18430	COG1131	(ABC) transporter
IRJ22_RS18455	COG3173	Aminoglycoside phosphotransferase
IRJ22_RS18460	COG1846	Transcriptional regulator
IRJ22_RS18465	COG0318	PFAM AMP-dependent synthetase and ligase
IRJ22_RS18485	COG0789	Transcriptional regulator
IRJ22_RS18510	COG0697	spore germination
IRJ22_RS18515	COG1714	RDD family
IRJ22_RS18520	COG1405	negative regulation of cell septum assembly
IRJ22_RS18520	COG3012	SEC-C Motif Domain Protein
IRJ22_RS18525	COG1131	(ABC) transporter
IRJ22_RS18550	COG0583	DNA-binding transcription factor activity
IRJ22_RS18555	COG1942	4-Oxalocrotonate Tautomerase
IRJ22_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS18575	COG1288	antiporter activity
IRJ22_RS18585	COG0456	acetyltransferase
IRJ22_RS18595	COG1164	Oligoendopeptidase f
IRJ22_RS18600	COG2261	transglycosylase associated protein
IRJ22_RS18610	COG0247	lactate metabolic process
IRJ22_RS18615	COG0277	FAD linked oxidase domain protein
IRJ22_RS18625	COG1447	Phosphotransferase system cellobiose-specific component IIA
IRJ22_RS18630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IRJ22_RS18635	COG1486	melibiose metabolic process
IRJ22_RS18640	COG2188	Transcriptional regulator
IRJ22_RS18645	COG3394	polysaccharide catabolic process
IRJ22_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS18675	COG1595	DNA-templated transcription, initiation
IRJ22_RS18685	COG3773	Cell wall hydrolase
IRJ22_RS18690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRJ22_RS18695	COG0791	NLP P60 protein
IRJ22_RS18695	COG3883	PFAM NLP P60 protein
IRJ22_RS18710	COG1309	transcriptional regulator
IRJ22_RS18730	COG2310	stress, protein
IRJ22_RS18735	COG2310	stress, protein
IRJ22_RS18740	COG2310	stress, protein
IRJ22_RS18745	COG0861	Integral membrane protein TerC family
IRJ22_RS18765	COG3853	Toxic anion resistance protein (TelA)
IRJ22_RS18770	COG0785	Cytochrome C biogenesis protein
IRJ22_RS18780	COG0789	Transcriptional regulator
IRJ22_RS18785	COG2223	nitrite transmembrane transporter activity
IRJ22_RS18790	COG0039	L-malate dehydrogenase activity
IRJ22_RS18795	COG1620	l-lactate permease
IRJ22_RS18800	COG1280	lysine exporter protein (LysE YggA)
IRJ22_RS18805	COG1113	amino acid transport
IRJ22_RS18810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IRJ22_RS18815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IRJ22_RS18820	COG3541	Predicted nucleotidyltransferase
IRJ22_RS18825	COG0506	proline dehydrogenase activity
IRJ22_RS18830	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS18835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS18840	COG2508	Transcriptional regulator
IRJ22_RS18845	COG3689	TIGRFAM TIGR03943 family protein
IRJ22_RS18850	COG0701	Predicted permease
IRJ22_RS18855	COG3458	cephalosporin-C deacetylase activity
IRJ22_RS18875	COG0765	amino acid transport
IRJ22_RS18880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRJ22_RS18885	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS18895	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS18905	COG3209	COG3209 Rhs family protein
IRJ22_RS18915	COG3266	domain, Protein
IRJ22_RS18915	COG0515	serine threonine protein kinase
IRJ22_RS18925	COG5444	nuclease activity
IRJ22_RS18950	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRJ22_RS18955	COG1177	transmembrane transport
IRJ22_RS18960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRJ22_RS18965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRJ22_RS18970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRJ22_RS18975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IRJ22_RS18980	COG0697	spore germination
IRJ22_RS18985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRJ22_RS18995	COG2819	hydrolase of the alpha beta superfamily
IRJ22_RS19005	COG2364	Membrane
IRJ22_RS19015	COG1131	(ABC) transporter
IRJ22_RS19045	COG1126	abc transporter atp-binding protein
IRJ22_RS19050	COG0765	amino acid transport
IRJ22_RS19055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRJ22_RS19060	COG3829	transcription factor binding
IRJ22_RS19065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRJ22_RS19070	COG0833	amino acid
IRJ22_RS19075	COG0010	Belongs to the arginase family
IRJ22_RS19080	COG0583	DNA-binding transcription factor activity
IRJ22_RS19085	COG0163	prenyltransferase activity
IRJ22_RS19090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IRJ22_RS19135	COG5444	nuclease activity
IRJ22_RS19155	COG2972	Histidine kinase
IRJ22_RS19160	COG4753	response regulator
IRJ22_RS19160	COG2207	Transcriptional regulator
IRJ22_RS19165	COG4213	ABC transporter substrate-binding protein
IRJ22_RS19175	COG4214	carbohydrate transport
IRJ22_RS19180	COG2271	Major facilitator Superfamily
IRJ22_RS19185	COG0456	acetyltransferase
IRJ22_RS19185	COG1846	Transcriptional regulator
IRJ22_RS19190	COG1874	Beta-galactosidase
IRJ22_RS19195	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
IRJ22_RS19200	COG3104	oligopeptide transport
IRJ22_RS19205	COG5434	Belongs to the glycosyl hydrolase 28 family
IRJ22_RS19215	COG0697	spore germination
IRJ22_RS19225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IRJ22_RS19230	COG0789	Transcriptional regulator
IRJ22_RS19235	COG1136	(ABC) transporter
IRJ22_RS19240	COG0577	efflux transmembrane transporter activity
IRJ22_RS19245	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS19250	COG3850	Histidine kinase
IRJ22_RS19250	COG5002	protein histidine kinase activity
IRJ22_RS19255	COG3290	protein histidine kinase activity
IRJ22_RS19255	COG0840	transmembrane signaling receptor activity
IRJ22_RS19270	COG0527	aspartate kinase activity
IRJ22_RS19275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRJ22_RS19280	COG4605	iron ion homeostasis
IRJ22_RS19285	COG4604	ABC transporter, ATP-binding protein
IRJ22_RS19290	COG4607	ABC-type enterochelin transport system periplasmic component
IRJ22_RS19295	COG2814	Major facilitator Superfamily
IRJ22_RS19300	COG1309	transcriptional regulator
IRJ22_RS19310	COG0778	Nitroreductase
IRJ22_RS19315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IRJ22_RS19320	COG0640	Transcriptional regulator
IRJ22_RS19325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRJ22_RS19330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRJ22_RS19335	COG0531	amino acid
IRJ22_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS19345	COG0697	spore germination
IRJ22_RS19355	COG4549	nuclear export factor GLE1
IRJ22_RS19360	COG2372	response to copper ion
IRJ22_RS19360	COG1276	copper resistance
IRJ22_RS19365	COG1349	DNA-binding transcription factor activity
IRJ22_RS19370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRJ22_RS19375	COG0243	molybdopterin cofactor binding
IRJ22_RS19380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRJ22_RS19385	COG2146	nitrite reductase [NAD(P)H] activity
IRJ22_RS19390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRJ22_RS19390	COG1587	Uroporphyrinogen-III synthase
IRJ22_RS19395	COG1802	Transcriptional regulator
IRJ22_RS19400	COG0471	metal ion transport
IRJ22_RS19415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS19430	COG3959	Transketolase, thiamine diphosphate binding domain
IRJ22_RS19435	COG3958	Transketolase
IRJ22_RS19440	COG0561	phosphatase activity
IRJ22_RS19445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IRJ22_RS19450	COG1914	H( )-stimulated, divalent metal cation uptake system
IRJ22_RS19455	COG4336	lyase activity
IRJ22_RS19460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IRJ22_RS19465	COG1984	allophanate hydrolase subunit 2
IRJ22_RS19470	COG1414	Transcriptional regulator
IRJ22_RS19475	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS19480	COG2213	PTS system mannitol-specific
IRJ22_RS19485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRJ22_RS19490	COG0246	Mannitol dehydrogenase
IRJ22_RS19495	COG3711	transcriptional antiterminator
IRJ22_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS19505	COG1917	Cupin 2, conserved barrel domain protein
IRJ22_RS19515	COG3871	stress protein (general stress protein 26)
IRJ22_RS19530	COG2814	Major facilitator Superfamily
IRJ22_RS19540	COG1522	sequence-specific DNA binding
IRJ22_RS19545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRJ22_RS19545	COG0551	DNA topoisomerase type I activity
IRJ22_RS19550	COG0531	amino acid
IRJ22_RS19560	COG0028	Belongs to the TPP enzyme family
IRJ22_RS19565	COG3397	chitin binding
IRJ22_RS19575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRJ22_RS19580	COG1914	H( )-stimulated, divalent metal cation uptake system
IRJ22_RS19585	COG2261	transglycosylase associated protein
IRJ22_RS19590	COG1027	Aspartate ammonia-lyase
IRJ22_RS19600	COG4876	unkown
IRJ22_RS19605	COG2217	Heavy metal translocating P-type atpase
IRJ22_RS19615	COG0662	Cupin 2, conserved barrel domain protein
IRJ22_RS19620	COG3729	General stress protein
IRJ22_RS19625	COG0628	permease
IRJ22_RS19630	COG1301	dicarboxylic acid transport
IRJ22_RS19635	COG1131	(ABC) transporter
IRJ22_RS19640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRJ22_RS19650	COG1960	acyl-CoA dehydrogenase activity
IRJ22_RS19665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRJ22_RS19670	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRJ22_RS19675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRJ22_RS19685	COG0513	Belongs to the DEAD box helicase family
IRJ22_RS19690	COG3402	PFAM membrane-flanked domain
IRJ22_RS19695	COG3428	Bacterial PH domain
IRJ22_RS19700	COG0705	Rhomboid family
IRJ22_RS19705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IRJ22_RS19710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IRJ22_RS19715	COG0864	Transcriptional regulator
IRJ22_RS19720	COG2337	Toxic component of a toxin-antitoxin (TA) module
IRJ22_RS19725	COG1366	Belongs to the anti-sigma-factor antagonist family
IRJ22_RS19730	COG1366	Belongs to the anti-sigma-factor antagonist family
IRJ22_RS19735	COG2172	sigma factor antagonist activity
IRJ22_RS19740	COG2208	phosphoserine phosphatase activity
IRJ22_RS19750	COG2172	sigma factor antagonist activity
IRJ22_RS19755	COG1191	sigma factor activity
IRJ22_RS19760	COG2208	phosphoserine phosphatase activity
IRJ22_RS19765	COG2183	response to ionizing radiation
IRJ22_RS19770	COG1309	transcriptional regulator
IRJ22_RS19775	COG2409	Drug exporters of the RND superfamily
IRJ22_RS19775	COG1033	growth of symbiont in host cell
IRJ22_RS19785	COG3091	SprT-like family
IRJ22_RS19825	COG0697	spore germination
IRJ22_RS19840	COG1476	TRANSCRIPTIONal
IRJ22_RS19845	COG3239	Fatty acid desaturase
IRJ22_RS19850	COG1278	Cold shock
IRJ22_RS19855	COG1063	alcohol dehydrogenase
IRJ22_RS19860	COG2364	Membrane
IRJ22_RS19865	COG1846	Transcriptional regulator
IRJ22_RS19870	COG0456	acetyltransferase
IRJ22_RS19875	COG2808	Putative FMN-binding domain
IRJ22_RS19885	COG1733	regulation of RNA biosynthetic process
IRJ22_RS19890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRJ22_RS19900	COG0583	DNA-binding transcription factor activity
IRJ22_RS19920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IRJ22_RS19925	COG1113	amino acid transport
IRJ22_RS19940	COG1595	DNA-templated transcription, initiation
IRJ22_RS19950	COG2755	lipolytic protein G-D-S-L family
IRJ22_RS19950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRJ22_RS19955	COG2814	Major facilitator Superfamily
IRJ22_RS19960	COG2972	Histidine kinase
IRJ22_RS19960	COG0745	RESPONSE REGULATOR receiver
IRJ22_RS19970	COG3279	Response regulator of the LytR AlgR family
IRJ22_RS19980	COG3764	Sortase (surface protein transpeptidase)
IRJ22_RS19985	COG2814	Major facilitator Superfamily
IRJ22_RS20025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IRJ22_RS20030	COG0802	atpase or kinase
IRJ22_RS20035	COG1214	PFAM Peptidase M22, glycoprotease
IRJ22_RS20040	COG0456	acetyltransferase
IRJ22_RS20045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IRJ22_RS20050	COG0488	(ABC) transporter
IRJ22_RS20055	COG0315	cyclic pyranopterin monophosphate synthase activity
IRJ22_RS20060	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IRJ22_RS20065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRJ22_RS20070	COG0805	protein transport
IRJ22_RS20080	COG1266	CAAX protease self-immunity
IRJ22_RS20085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRJ22_RS20090	COG0459	protein refolding
IRJ22_RS20105	COG2720	vancomycin resistance protein
IRJ22_RS20120	COG2135	peptidase activity
IRJ22_RS20130	COG1309	transcriptional regulator
IRJ22_RS20135	COG3848	Pyruvate phosphate dikinase
IRJ22_RS20135	COG0574	Belongs to the PEP-utilizing enzyme family
IRJ22_RS20145	COG3189	MarR family transcriptional regulator
IRJ22_RS20150	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IRJ22_RS20155	COG2272	Belongs to the type-B carboxylesterase lipase family
IRJ22_RS20160	COG2814	Major facilitator Superfamily
IRJ22_RS20165	COG1842	Phage shock protein A
IRJ22_RS20170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRJ22_RS20175	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IRJ22_RS20180	COG4260	virion core protein, lumpy skin disease virus
IRJ22_RS20190	COG1378	Sugar-specific transcriptional regulator TrmB
IRJ22_RS20195	COG1280	lysine exporter protein (LysE YggA)
IRJ22_RS20200	COG3339	Conserved Protein
IRJ22_RS20205	COG0772	Belongs to the SEDS family
IRJ22_RS20210	COG0772	Belongs to the SEDS family
IRJ22_RS20230	COG0726	polysaccharide deacetylase
IRJ22_RS20240	COG1609	Transcriptional regulator
IRJ22_RS20245	COG0366	Alpha amylase catalytic
IRJ22_RS20250	COG2182	Extracellular solute-binding protein
IRJ22_RS20255	COG1175	transmembrane transport
IRJ22_RS20260	COG3833	ABC-type maltose transport systems, permease component
IRJ22_RS20265	COG5521	maltodextrose utilization protein MalA
IRJ22_RS20270	COG1554	hydrolase, family 65, central catalytic
IRJ22_RS20275	COG0366	Alpha amylase catalytic
IRJ22_RS20280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IRJ22_RS20285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IRJ22_RS20290	COG1846	Transcriptional regulator
IRJ22_RS20305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IRJ22_RS20310	COG0823	Involved in the tonB-independent uptake of proteins
IRJ22_RS20340	COG0702	epimerase
IRJ22_RS20350	COG2132	Multicopper oxidase
IRJ22_RS20365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRJ22_RS20370	COG0714	Associated with various cellular activities
IRJ22_RS20375	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
IRJ22_RS20380	COG1305	Transglutaminase-like
IRJ22_RS20385	COG0519	Catalyzes the synthesis of GMP from XMP
IRJ22_RS20385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IRJ22_RS20390	COG2252	PERMEase
IRJ22_RS20405	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IRJ22_RS20415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IRJ22_RS20420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IRJ22_RS20425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IRJ22_RS20430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IRJ22_RS20435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRJ22_RS20440	COG0047	phosphoribosylformylglycinamidine synthase activity
IRJ22_RS20445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRJ22_RS20450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IRJ22_RS20455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IRJ22_RS20460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IRJ22_RS20465	COG0138	bifunctional purine biosynthesis protein purh
IRJ22_RS20470	COG0151	Belongs to the GarS family
IRJ22_RS20485	COG2124	cytochrome p450
IRJ22_RS20510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRJ22_RS20515	COG1470	cell adhesion involved in biofilm formation
IRJ22_RS20520	COG4496	protein, YerC YecD
IRJ22_RS20525	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IRJ22_RS20530	COG0210	DNA helicase
IRJ22_RS20535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IRJ22_RS20540	COG4851	CamS sex pheromone cAM373 precursor
IRJ22_RS20545	COG2188	Transcriptional regulator
IRJ22_RS20565	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IRJ22_RS20570	COG0626	cystathionine gamma-synthase activity
IRJ22_RS20575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IRJ22_RS20580	COG3457	Alanine racemase
IRJ22_RS20585	COG0363	glucosamine-6-phosphate deaminase activity
IRJ22_RS20590	COG1285	pathogenesis
IRJ22_RS20595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRJ22_RS20605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRJ22_RS20610	COG0154	amidase activity
IRJ22_RS20615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRJ22_RS20630	COG4124	Belongs to the glycosyl hydrolase 26 family
IRJ22_RS20635	COG1309	transcriptional regulator
IRJ22_RS20640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRJ22_RS20650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRJ22_RS20655	COG1957	nucleoside hydrolase
IRJ22_RS20660	COG1597	lipid kinase activity
IRJ22_RS20665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRJ22_RS20715	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IRJ22_RS20740	COG1715	Restriction endonuclease
IRJ22_RS20760	COG2190	(PTS) system
IRJ22_RS20760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS20760	COG1263	PTS System
IRJ22_RS20765	COG2723	6-phospho-beta-galactosidase activity
IRJ22_RS20770	COG3711	transcriptional antiterminator
IRJ22_RS20775	COG0457	Tetratricopeptide repeat
IRJ22_RS20790	COG0217	transcriptional regulatory protein
IRJ22_RS20805	COG1012	belongs to the aldehyde dehydrogenase family
IRJ22_RS20810	COG0840	transmembrane signaling receptor activity
IRJ22_RS20815	COG0471	metal ion transport
IRJ22_RS20820	COG0488	(ABC) transporter
IRJ22_RS20830	COG1469	GTP cyclohydrolase I activity
IRJ22_RS20845	COG0523	cobalamin synthesis protein
IRJ22_RS20850	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
IRJ22_RS20855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRJ22_RS20860	COG0156	8-amino-7-oxononanoate synthase activity
IRJ22_RS20865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IRJ22_RS20870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IRJ22_RS20875	COG2124	cytochrome p450
IRJ22_RS20885	COG0789	Transcriptional regulator
IRJ22_RS20890	COG2814	Major facilitator Superfamily
IRJ22_RS20895	COG0488	(ABC) transporter
IRJ22_RS20900	COG0513	Belongs to the DEAD box helicase family
IRJ22_RS20905	COG2130	NADP-dependent
IRJ22_RS20920	COG0471	metal ion transport
IRJ22_RS20940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRJ22_RS20950	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IRJ22_RS20955	COG5658	integral membrane protein
IRJ22_RS20960	COG0640	Transcriptional regulator
IRJ22_RS20965	COG1254	Belongs to the acylphosphatase family
IRJ22_RS20970	COG2258	MOSC domain
IRJ22_RS20985	COG0024	Methionine aminopeptidase
IRJ22_RS20990	COG1368	sulfuric ester hydrolase activity
IRJ22_RS21000	COG1115	amino acid carrier protein
IRJ22_RS21005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS21005	COG1263	PTS System
IRJ22_RS21010	COG0366	Alpha amylase catalytic
IRJ22_RS21015	COG2188	Transcriptional regulator
IRJ22_RS21040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IRJ22_RS21045	COG1045	serine acetyltransferase
IRJ22_RS21050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRJ22_RS21060	COG1215	transferase activity, transferring glycosyl groups
IRJ22_RS21065	COG0457	Tetratricopeptide repeat
IRJ22_RS21065	COG0463	Glycosyl transferase, family 2
IRJ22_RS21075	COG0673	inositol 2-dehydrogenase activity
IRJ22_RS21085	COG0657	acetylesterase activity
IRJ22_RS21090	COG1733	regulation of RNA biosynthetic process
IRJ22_RS21095	COG0778	Nitroreductase
IRJ22_RS21100	COG0737	Belongs to the 5'-nucleotidase family
IRJ22_RS21105	COG0693	protein deglycase activity
IRJ22_RS21110	COG4840	Belongs to the UPF0435 family
IRJ22_RS21115	COG1115	amino acid carrier protein
IRJ22_RS21120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRJ22_RS21125	COG4980	gas vesicle protein
IRJ22_RS21130	COG1295	ribonuclease BN
IRJ22_RS21135	COG0477	Major facilitator Superfamily
IRJ22_RS21145	COG0387	Pfam Sodium calcium exchanger
IRJ22_RS21155	COG0535	radical SAM domain protein
IRJ22_RS21165	COG0726	polysaccharide deacetylase
IRJ22_RS21170	COG0371	Dehydrogenase
IRJ22_RS21180	COG0598	Magnesium transport protein CorA
IRJ22_RS21185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IRJ22_RS21190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRJ22_RS21195	COG4637	Psort location Cytoplasmic, score
IRJ22_RS21220	COG1819	glycosyl
IRJ22_RS21230	COG0477	Major facilitator Superfamily
IRJ22_RS21235	COG1263	PTS System
IRJ22_RS21235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS21240	COG3711	transcriptional antiterminator
IRJ22_RS21245	COG0288	reversible hydration of carbon dioxide
IRJ22_RS21250	COG3002	Belongs to the UPF0753 family
IRJ22_RS21255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IRJ22_RS21260	COG5609	conserved protein (DUF2294)
IRJ22_RS21270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRJ22_RS21275	COG0022	dehydrogenase e1 component
IRJ22_RS21280	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRJ22_RS21285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRJ22_RS21290	COG3284	Transcriptional regulator
IRJ22_RS21295	COG1742	UPF0060 membrane protein
IRJ22_RS21300	COG1486	melibiose metabolic process
IRJ22_RS21305	COG1737	Transcriptional regulator
IRJ22_RS21310	COG1263	PTS System
IRJ22_RS21310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRJ22_RS21325	COG1733	regulation of RNA biosynthetic process
IRJ22_RS21330	COG2259	Doxx family
IRJ22_RS21335	COG2514	catechol 2,3-dioxygenase activity
IRJ22_RS21345	COG3507	Belongs to the glycosyl hydrolase 43 family
IRJ22_RS21350	COG2207	Transcriptional regulator
IRJ22_RS21350	COG1917	Cupin 2, conserved barrel domain protein
IRJ22_RS21355	COG1653	transport
IRJ22_RS21360	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRJ22_RS21365	COG1051	belongs to the nudix hydrolase family
IRJ22_RS21375	COG0392	lysyltransferase activity
IRJ22_RS21375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IRJ22_RS21380	COG0384	phenazine biosynthesis protein PhzF
IRJ22_RS21385	COG0778	Nitroreductase
IRJ22_RS21410	COG2137	regulation of response to DNA damage stimulus
IRJ22_RS21435	COG0463	Glycosyl transferase, family 2
IRJ22_RS21445	COG4485	Bacterial membrane protein, YfhO
IRJ22_RS21450	COG1988	membrane-bound metal-dependent
IRJ22_RS21455	COG1194	a g-specific adenine glycosylase
IRJ22_RS21465	COG1028	Short-chain dehydrogenase reductase Sdr
IRJ22_RS21480	COG3557	Belongs to the UPF0374 family
IRJ22_RS21485	COG1132	(ABC) transporter
IRJ22_RS21490	COG0444	Belongs to the ABC transporter superfamily
IRJ22_RS21495	COG4608	Belongs to the ABC transporter superfamily
IRJ22_RS21500	COG0747	negative chemotaxis
IRJ22_RS21505	COG0601	transmembrane transport
IRJ22_RS21510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRJ22_RS21515	COG4129	membrane
IRJ22_RS21520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRJ22_RS21525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRJ22_RS21530	COG0735	belongs to the Fur family
IRJ22_RS21635	COG4974	Belongs to the 'phage' integrase family
IRJ22_RS21815	COG1780	Probably involved in ribonucleotide reductase function
IRJ22_RS21820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRJ22_RS21845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IRJ22_RS21850	COG3584	3D domain protein
IRJ22_RS21855	COG1388	LysM domain
IRJ22_RS21855	COG3584	3D domain protein
IRJ22_RS21915	COG1793	dna ligase
IRJ22_RS21975	COG0740	serine-type endopeptidase activity
IRJ22_RS22025	COG5280	Phage tail tape measure protein TP901
IRJ22_RS22025	COG3953	SLT domain
IRJ22_RS22065	COG3409	Peptidoglycan-binding domain 1 protein
IRJ22_RS22065	COG1388	LysM domain
IRJ22_RS22065	COG5632	N-Acetylmuramoyl-L-alanine amidase
IRJ22_RS22085	COG0438	transferase activity, transferring glycosyl groups
IRJ22_RS22100	COG4974	Belongs to the 'phage' integrase family