locus-tag	class	description
D6022_RS00100	COG0582	viral genome integration into host DNA
D6022_RS00225	COG1396	sequence-specific DNA binding
D6022_RS00250	COG0740	serine-type endopeptidase activity
D6022_RS00255	COG1611	Belongs to the LOG family
D6022_RS00260	COG1694	Mazg nucleotide pyrophosphohydrolase
D6022_RS00265	COG1078	dGTPase activity
D6022_RS00270	COG0659	secondary active sulfate transmembrane transporter activity
D6022_RS00275	COG0288	reversible hydration of carbon dioxide
D6022_RS00280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D6022_RS00285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D6022_RS00290	COG0640	Transcriptional regulator
D6022_RS00300	COG2732	(Barnase) inhibitor
D6022_RS00305	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D6022_RS00310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS00315	COG1481	regulation of sporulation
D6022_RS00320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D6022_RS00325	COG1660	Displays ATPase and GTPase activities
D6022_RS00330	COG1051	belongs to the nudix hydrolase family
D6022_RS00340	COG0492	ferredoxin-NADP+ reductase activity
D6022_RS00345	COG0457	Tetratricopeptide repeat
D6022_RS00350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS00355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D6022_RS00355	COG0140	phosphoribosyl-ATP diphosphatase activity
D6022_RS00360	COG0107	imidazoleglycerol-phosphate synthase activity
D6022_RS00365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D6022_RS00370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D6022_RS00375	COG0131	Imidazoleglycerol-phosphate dehydratase
D6022_RS00380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D6022_RS00385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D6022_RS00390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D6022_RS00395	COG4990	cell redox homeostasis
D6022_RS00400	COG5297	Belongs to the glycosyl hydrolase family 6
D6022_RS00405	COG0110	maltose O-acetyltransferase activity
D6022_RS00410	COG0546	phosphoglycolate phosphatase activity
D6022_RS00415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D6022_RS00420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D6022_RS00425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D6022_RS00430	COG1846	Transcriptional regulator
D6022_RS00435	COG2814	Major facilitator Superfamily
D6022_RS00440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D6022_RS00445	COG1950	PFAM Membrane protein of
D6022_RS00450	COG1983	PspC domain protein
D6022_RS00455	COG3595	metallopeptidase activity
D6022_RS00480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6022_RS00485	COG0556	nucleotide-excision repair
D6022_RS00490	COG4897	Protein conserved in bacteria
D6022_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6022_RS00510	COG3409	Peptidoglycan-binding domain 1 protein
D6022_RS00510	COG0793	Belongs to the peptidase S41A family
D6022_RS00515	COG0473	3-isopropylmalate dehydrogenase activity
D6022_RS00520	COG0791	NLP P60 protein
D6022_RS00520	COG3883	PFAM NLP P60 protein
D6022_RS00525	COG2177	Part of the ABC transporter FtsEX involved in
D6022_RS00530	COG2884	Cell division ATP-binding protein ftsE
D6022_RS00540	COG2010	Cytochrome c
D6022_RS00545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS00555	COG0653	protein targeting
D6022_RS00560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D6022_RS00575	COG1516	flagellar protein fliS
D6022_RS00580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D6022_RS00585	COG1334	flagellar protein FlaG
D6022_RS00590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D6022_RS00595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D6022_RS00600	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D6022_RS00610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D6022_RS00615	COG1256	bacterial-type flagellum assembly
D6022_RS00615	COG4786	Flagellar basal body rod
D6022_RS00620	COG3418	PFAM FlgN family protein
D6022_RS00625	COG2747	anti-sigma28 factor FlgM
D6022_RS00635	COG1040	competence protein
D6022_RS00645	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D6022_RS00650	COG1307	EDD domain protein, DegV family
D6022_RS00655	COG2197	response regulator
D6022_RS00660	COG4585	Histidine kinase
D6022_RS00665	COG1739	Uncharacterized protein family UPF0029
D6022_RS00670	COG1316	TRANSCRIPTIONal
D6022_RS00680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6022_RS00685	COG0438	transferase activity, transferring glycosyl groups
D6022_RS00690	COG1215	transferase activity, transferring glycosyl groups
D6022_RS00700	COG3307	-O-antigen
D6022_RS00705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6022_RS00710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D6022_RS00720	COG2244	polysaccharide biosynthetic process
D6022_RS00730	COG2247	cell wall binding repeat
D6022_RS00730	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS00735	COG2247	cell wall binding repeat
D6022_RS00735	COG2385	sporulation resulting in formation of a cellular spore
D6022_RS00745	COG1316	TRANSCRIPTIONal
D6022_RS00750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D6022_RS00755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D6022_RS00760	COG1134	teichoic acid transport
D6022_RS00765	COG1682	transport, permease protein
D6022_RS00770	COG0463	Glycosyl transferase, family 2
D6022_RS00770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6022_RS00775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6022_RS00780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D6022_RS00785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D6022_RS00790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6022_RS00795	COG4193	domain, Protein
D6022_RS00800	COG1482	cell wall glycoprotein biosynthetic process
D6022_RS00820	COG0800	Aldolase
D6022_RS00825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6022_RS00830	COG1609	Transcriptional regulator
D6022_RS00835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D6022_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS00845	COG1063	alcohol dehydrogenase
D6022_RS00850	COG2814	Major facilitator Superfamily
D6022_RS00855	COG1316	TRANSCRIPTIONal
D6022_RS00860	COG0561	phosphatase activity
D6022_RS00865	COG0791	NLP P60 protein
D6022_RS00870	COG2843	Capsule synthesis protein
D6022_RS00880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D6022_RS00885	COG1609	Transcriptional regulator
D6022_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6022_RS00895	COG1869	D-ribose catabolic process
D6022_RS00900	COG1129	ABC transporter
D6022_RS00905	COG1172	Belongs to the binding-protein-dependent transport system permease family
D6022_RS00910	COG1879	ABC-type sugar transport system periplasmic component
D6022_RS00920	COG3527	Alpha-acetolactate decarboxylase
D6022_RS00925	COG0028	Belongs to the TPP enzyme family
D6022_RS00930	COG0583	DNA-binding transcription factor activity
D6022_RS00940	COG0405	Gamma-glutamyltransferase
D6022_RS00945	COG1522	sequence-specific DNA binding
D6022_RS00950	COG2059	Chromate
D6022_RS00955	COG2059	Chromate
D6022_RS00960	COG4464	protein tyrosine phosphatase activity
D6022_RS00965	COG3944	biosynthesis protein
D6022_RS00975	COG4715	Zinc finger, swim domain protein
D6022_RS00980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6022_RS00985	COG0561	phosphatase activity
D6022_RS00990	COG1349	DNA-binding transcription factor activity
D6022_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS01010	COG3732	PTS system glucitol sorbitol-specific
D6022_RS01030	COG0629	single-stranded DNA binding
D6022_RS01045	COG1970	mechanosensitive ion channel activity
D6022_RS01050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D6022_RS01055	COG4786	Flagellar basal body rod
D6022_RS01060	COG4786	Flagellar basal body rod
D6022_RS01065	COG1077	Cell shape determining protein MreB Mrl
D6022_RS01070	COG1609	Transcriptional regulator
D6022_RS01080	COG1846	Transcriptional regulator
D6022_RS01085	COG2814	Major facilitator Superfamily
D6022_RS01090	COG0671	phosphoesterase, PA-phosphatase related
D6022_RS01095	COG1227	inorganic diphosphatase activity
D6022_RS01100	COG3546	catalase activity
D6022_RS01105	COG3361	conserved protein (COG2071)
D6022_RS01110	COG0517	IMP dehydrogenase activity
D6022_RS01115	COG0598	Magnesium transport protein CorA
D6022_RS01120	COG1253	flavin adenine dinucleotide binding
D6022_RS01125	COG0004	ammonium transporteR
D6022_RS01130	COG0347	Belongs to the P(II) protein family
D6022_RS01135	COG0740	serine-type endopeptidase activity
D6022_RS01145	COG0739	heme binding
D6022_RS01150	COG1247	-acetyltransferase
D6022_RS01160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D6022_RS01170	COG0477	Major facilitator Superfamily
D6022_RS01175	COG3251	PFAM MbtH domain protein
D6022_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6022_RS01185	COG3433	isochorismatase activity
D6022_RS01185	COG1535	isochorismatase
D6022_RS01190	COG1021	2,3-dihydroxybenzoate-AMP ligase
D6022_RS01195	COG1169	isochorismate synthase
D6022_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS01205	COG2819	hydrolase of the alpha beta superfamily
D6022_RS01210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS01215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS01220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS01225	COG2207	Transcriptional regulator
D6022_RS01225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS01235	COG2910	NAD(P)H-binding
D6022_RS01240	COG1959	2 iron, 2 sulfur cluster binding
D6022_RS01250	COG1994	Peptidase M50
D6022_RS01255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D6022_RS01260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D6022_RS01265	COG2223	nitrite transmembrane transporter activity
D6022_RS01270	COG3383	formate dehydrogenase (NAD+) activity
D6022_RS01275	COG2304	oxidoreductase activity
D6022_RS01280	COG2304	oxidoreductase activity
D6022_RS01285	COG2385	sporulation resulting in formation of a cellular spore
D6022_RS01290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D6022_RS01300	COG4836	Membrane
D6022_RS01305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D6022_RS01310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D6022_RS01315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D6022_RS01320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D6022_RS01325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6022_RS01330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D6022_RS01335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6022_RS01355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D6022_RS01360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D6022_RS01365	COG4475	Protein of unknown function (DUF436)
D6022_RS01370	COG0698	ribose 5-phosphate isomerase
D6022_RS01375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6022_RS01380	COG1971	Probably functions as a manganese efflux pump
D6022_RS01385	COG0009	L-threonylcarbamoyladenylate synthase
D6022_RS01390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D6022_RS01405	COG0673	inositol 2-dehydrogenase activity
D6022_RS01410	COG0561	phosphatase activity
D6022_RS01415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6022_RS01420	COG1609	Transcriptional regulator
D6022_RS01425	COG2890	protein-(glutamine-N5) methyltransferase activity
D6022_RS01430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D6022_RS01435	COG0346	lactoylglutathione lyase activity
D6022_RS01440	COG0789	Transcriptional regulator
D6022_RS01445	COG0679	Auxin Efflux Carrier
D6022_RS01450	COG0281	malic enzyme
D6022_RS01455	COG1435	thymidine kinase activity
D6022_RS01460	COG0254	rRNA binding
D6022_RS01465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D6022_RS01470	COG1494	fructose-1,6-bisphosphatase
D6022_RS01475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D6022_RS01480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D6022_RS01485	COG0191	fructose-bisphosphate aldolase activity
D6022_RS01490	COG2204	response regulator
D6022_RS01495	COG4821	SIS domain
D6022_RS01500	COG0504	CTP synthase activity
D6022_RS01505	COG3343	RNA polymerase activity
D6022_RS01510	COG1960	acyl-CoA dehydrogenase activity
D6022_RS01515	COG1960	acyl-CoA dehydrogenase activity
D6022_RS01520	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6022_RS01525	COG0183	Belongs to the thiolase family
D6022_RS01530	COG2181	nitrate reductase activity
D6022_RS01530	COG0247	lactate metabolic process
D6022_RS01535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D6022_RS01545	COG0018	arginyl-trna synthetase
D6022_RS01550	COG4506	Protein conserved in bacteria
D6022_RS01555	COG0010	Belongs to the arginase family
D6022_RS01560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D6022_RS01575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6022_RS01585	COG1994	Peptidase M50
D6022_RS01590	COG1942	4-Oxalocrotonate Tautomerase
D6022_RS01600	COG3465	dGTPase activity
D6022_RS01605	COG1078	dGTPase activity
D6022_RS01610	COG4844	belongs to the
D6022_RS01635	COG2814	Major facilitator Superfamily
D6022_RS01660	COG1414	Transcriptional regulator
D6022_RS01670	COG0280	phosphate acetyltransferase
D6022_RS01675	COG3253	May function as heme-dependent peroxidase
D6022_RS01690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D6022_RS01710	COG1131	(ABC) transporter
D6022_RS01725	COG2363	Small membrane protein
D6022_RS01730	COG2233	PERMEase
D6022_RS01740	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS01745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D6022_RS01750	COG1216	Glycosyl transferase, family 2
D6022_RS01755	COG0351	phosphomethylpyrimidine kinase
D6022_RS01765	COG1621	beta-fructofuranosidase activity
D6022_RS01770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS01770	COG1263	PTS System
D6022_RS01775	COG3711	transcriptional antiterminator
D6022_RS01785	COG1404	Belongs to the peptidase S8 family
D6022_RS01795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6022_RS01800	COG0778	Nitroreductase
D6022_RS01805	COG1473	amidohydrolase
D6022_RS01810	COG0772	Belongs to the SEDS family
D6022_RS01815	COG0772	Belongs to the SEDS family
D6022_RS01820	COG3314	Sporulation integral membrane protein YlbJ
D6022_RS01840	COG0456	acetyltransferase
D6022_RS01875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D6022_RS01885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D6022_RS01890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D6022_RS01895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6022_RS01915	COG3162	membrane
D6022_RS01920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS01925	COG1070	Carbohydrate kinase
D6022_RS01930	COG2115	Belongs to the xylose isomerase family
D6022_RS01940	COG0352	thiamine-phosphate diphosphorylase activity
D6022_RS01945	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D6022_RS01950	COG0583	DNA-binding transcription factor activity
D6022_RS01965	COG1380	Effector of murein hydrolase LrgA
D6022_RS01970	COG1346	cytolysis
D6022_RS01980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS01985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D6022_RS01990	COG0346	lactoylglutathione lyase activity
D6022_RS01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D6022_RS02000	COG1442	glycosyl transferase family 8
D6022_RS02010	COG4585	Histidine kinase
D6022_RS02015	COG2197	response regulator
D6022_RS02020	COG2409	Drug exporters of the RND superfamily
D6022_RS02025	COG5522	Integral membrane protein (intg_mem_TP0381)
D6022_RS02030	COG2271	Major facilitator Superfamily
D6022_RS02035	COG4948	Mandelate Racemase Muconate Lactonizing
D6022_RS02040	COG0800	Aldolase
D6022_RS02045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6022_RS02055	COG2234	aminopeptidase activity
D6022_RS02060	COG0477	Major facilitator Superfamily
D6022_RS02070	COG2357	RelA SpoT domain protein
D6022_RS02085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6022_RS02090	COG1696	Membrane protein involved in D-alanine export
D6022_RS02095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D6022_RS02100	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D6022_RS02105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D6022_RS02110	COG2814	Major facilitator Superfamily
D6022_RS02115	COG1486	melibiose metabolic process
D6022_RS02120	COG1447	Phosphotransferase system cellobiose-specific component IIA
D6022_RS02125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS02130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS02135	COG3711	transcriptional antiterminator
D6022_RS02135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS02140	COG2094	Belongs to the DNA glycosylase MPG family
D6022_RS02150	COG0372	Belongs to the citrate synthase family
D6022_RS02155	COG2079	MmgE PrpD family protein
D6022_RS02160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D6022_RS02175	COG1132	(ABC) transporter
D6022_RS02180	COG2755	lipolytic protein G-D-S-L family
D6022_RS02195	COG2814	Major facilitator Superfamily
D6022_RS02200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D6022_RS02205	COG1131	(ABC) transporter
D6022_RS02225	COG1595	DNA-templated transcription, initiation
D6022_RS02230	COG2814	Major facilitator Superfamily
D6022_RS02235	COG0753	catalase activity
D6022_RS02240	COG0753	catalase activity
D6022_RS02245	COG0735	belongs to the Fur family
D6022_RS02250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D6022_RS02255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D6022_RS02260	COG1131	(ABC) transporter
D6022_RS02330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D6022_RS02335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D6022_RS02340	COG4988	ABC transporter
D6022_RS02345	COG1294	oxidase, subunit
D6022_RS02350	COG1271	oxidase subunit
D6022_RS02360	COG2116	formate transmembrane transporter activity
D6022_RS02370	COG0281	malic enzyme
D6022_RS02375	COG1757	Na H antiporter
D6022_RS02380	COG1027	Aspartate ammonia-lyase
D6022_RS02385	COG0252	asparaginase activity
D6022_RS02390	COG1396	sequence-specific DNA binding
D6022_RS02395	COG2706	6-phosphogluconolactonase activity
D6022_RS02400	COG0745	RESPONSE REGULATOR receiver
D6022_RS02405	COG2205	protein histidine kinase activity
D6022_RS02415	COG1136	(ABC) transporter
D6022_RS02420	COG0577	efflux transmembrane transporter activity
D6022_RS02425	COG5294	Protein conserved in bacteria
D6022_RS02435	COG0726	polysaccharide deacetylase
D6022_RS02440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6022_RS02455	COG3493	citrate carrier protein
D6022_RS02460	COG0584	glycerophosphoryl diester phosphodiesterase
D6022_RS02475	COG1368	sulfuric ester hydrolase activity
D6022_RS02485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS02505	COG2235	arginine
D6022_RS02510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D6022_RS02520	COG0549	Belongs to the carbamate kinase family
D6022_RS02535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS02545	COG1595	DNA-templated transcription, initiation
D6022_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D6022_RS02575	COG2195	Cleaves the N-terminal amino acid of tripeptides
D6022_RS02585	COG1621	beta-fructofuranosidase activity
D6022_RS02600	COG1609	Transcriptional regulator
D6022_RS02615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D6022_RS02620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D6022_RS02625	COG0463	Glycosyl transferase, family 2
D6022_RS02630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6022_RS02655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D6022_RS02670	COG2723	6-phospho-beta-galactosidase activity
D6022_RS02675	COG2190	(PTS) system
D6022_RS02675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS02675	COG1263	PTS System
D6022_RS02680	COG3711	transcriptional antiterminator
D6022_RS02685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D6022_RS02690	COG1122	ATPase activity
D6022_RS02695	COG4721	ABC-type cobalt transport system, permease component
D6022_RS02700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D6022_RS02705	COG2224	Isocitrate lyase
D6022_RS02710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D6022_RS02720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D6022_RS02725	COG0577	efflux transmembrane transporter activity
D6022_RS02730	COG1136	(ABC) transporter
D6022_RS02735	COG2205	protein histidine kinase activity
D6022_RS02740	COG0745	RESPONSE REGULATOR receiver
D6022_RS02745	COG2723	6-phospho-beta-galactosidase activity
D6022_RS02750	COG2190	(PTS) system
D6022_RS02750	COG1263	PTS System
D6022_RS02750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS02760	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D6022_RS02770	COG3507	Belongs to the glycosyl hydrolase 43 family
D6022_RS02775	COG0513	Belongs to the DEAD box helicase family
D6022_RS02805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D6022_RS02810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D6022_RS02815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D6022_RS02820	COG2390	Transcriptional regulator
D6022_RS02830	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D6022_RS02835	COG3706	GGDEF domain
D6022_RS02840	COG5298	Protein conserved in bacteria
D6022_RS02845	COG1215	transferase activity, transferring glycosyl groups
D6022_RS02855	COG3977	Valine--pyruvate aminotransferase
D6022_RS02870	COG1181	Belongs to the D-alanine--D-alanine ligase family
D6022_RS02880	COG0191	fructose-bisphosphate aldolase activity
D6022_RS02885	COG1082	Xylose isomerase domain protein TIM barrel
D6022_RS02890	COG1082	Xylose isomerase domain protein TIM barrel
D6022_RS02895	COG0673	inositol 2-dehydrogenase activity
D6022_RS02900	COG2814	Major facilitator Superfamily
D6022_RS02905	COG1082	Xylose isomerase domain protein TIM barrel
D6022_RS02910	COG3962	Belongs to the TPP enzyme family
D6022_RS02915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6022_RS02920	COG3718	enzyme involved in inositol metabolism
D6022_RS02925	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS02930	COG1349	DNA-binding transcription factor activity
D6022_RS02935	COG0667	Aldo Keto reductase
D6022_RS02940	COG0584	glycerophosphoryl diester phosphodiesterase
D6022_RS02945	COG2271	Major facilitator Superfamily
D6022_RS02950	COG0326	Molecular chaperone. Has ATPase activity
D6022_RS02955	COG0488	(ABC) transporter
D6022_RS02960	COG0561	phosphatase activity
D6022_RS02980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS03010	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D6022_RS03015	COG0577	efflux transmembrane transporter activity
D6022_RS03020	COG1136	(ABC) transporter
D6022_RS03025	COG2205	protein histidine kinase activity
D6022_RS03030	COG0745	RESPONSE REGULATOR receiver
D6022_RS03040	COG5278	phosphoserine phosphatase activity
D6022_RS03040	COG0840	transmembrane signaling receptor activity
D6022_RS03045	COG1115	amino acid carrier protein
D6022_RS03050	COG0686	Belongs to the AlaDH PNT family
D6022_RS03055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D6022_RS03060	COG1874	Beta-galactosidase
D6022_RS03065	COG3833	ABC-type maltose transport systems, permease component
D6022_RS03070	COG1175	transmembrane transport
D6022_RS03075	COG2182	Extracellular solute-binding protein
D6022_RS03080	COG1609	Transcriptional regulator
D6022_RS03090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6022_RS03095	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D6022_RS03100	COG1940	carbohydrate kinase activity
D6022_RS03125	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS03125	COG1454	alcohol dehydrogenase
D6022_RS03130	COG0450	alkyl hydroperoxide reductase
D6022_RS03135	COG3634	alkyl hydroperoxide reductase activity
D6022_RS03160	COG1131	(ABC) transporter
D6022_RS03165	COG0842	Transport permease protein
D6022_RS03175	COG2197	response regulator
D6022_RS03200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D6022_RS03215	COG0456	acetyltransferase
D6022_RS03230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6022_RS03235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D6022_RS03240	COG4853	Protein conserved in bacteria
D6022_RS03245	COG4863	YycH protein
D6022_RS03250	COG5002	protein histidine kinase activity
D6022_RS03255	COG0745	RESPONSE REGULATOR receiver
D6022_RS03280	COG1051	belongs to the nudix hydrolase family
D6022_RS03285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D6022_RS03295	COG0305	Participates in initiation and elongation during chromosome replication
D6022_RS03310	COG3093	addiction module antidote protein HigA
D6022_RS03315	COG2807	transmembrane transport
D6022_RS03320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D6022_RS03325	COG0363	glucosamine-6-phosphate deaminase activity
D6022_RS03330	COG2188	Transcriptional regulator
D6022_RS03335	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D6022_RS03340	COG1263	PTS System
D6022_RS03340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS03345	COG0359	binds to the 23S rRNA
D6022_RS03350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D6022_RS03355	COG4241	membrane
D6022_RS03360	COG5577	PFAM Coat F domain
D6022_RS03365	COG0589	response to stress
D6022_RS03370	COG0659	secondary active sulfate transmembrane transporter activity
D6022_RS03380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D6022_RS03385	COG0629	single-stranded DNA binding
D6022_RS03390	COG0360	Binds together with S18 to 16S ribosomal RNA
D6022_RS03395	COG0012	GTP binding
D6022_RS03405	COG4481	Protein conserved in bacteria
D6022_RS03410	COG3949	Membrane
D6022_RS03420	COG1475	DNA binding
D6022_RS03425	COG1192	Involved in chromosome partitioning
D6022_RS03430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6022_RS03440	COG1475	DNA binding
D6022_RS03445	COG0357	Ribosomal RNA small subunit methyltransferase G
D6022_RS03450	COG0445	tRNA wobble uridine modification
D6022_RS03455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D6022_RS03460	COG1847	R3H domain protein
D6022_RS03465	COG0706	membrane insertase activity
D6022_RS03470	COG0594	ribonuclease P activity
D6022_RS03480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D6022_RS03485	COG0592	DNA-directed DNA polymerase activity
D6022_RS03490	COG2501	S4 domain
D6022_RS03495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D6022_RS03505	COG0187	DNA topoisomerase II activity
D6022_RS03510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D6022_RS03545	COG0517	IMP dehydrogenase activity
D6022_RS03545	COG0516	GMP reductase activity
D6022_RS03550	COG1686	Belongs to the peptidase S11 family
D6022_RS03555	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D6022_RS03560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D6022_RS03565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D6022_RS03570	COG1929	Belongs to the glycerate kinase type-1 family
D6022_RS03575	COG2610	gluconate transmembrane transporter activity
D6022_RS03580	COG3835	regulator
D6022_RS03595	COG1428	Deoxynucleoside kinase
D6022_RS03600	COG1428	Deoxynucleoside kinase
D6022_RS03605	COG1388	LysM domain
D6022_RS03605	COG3858	chitin binding
D6022_RS03610	COG1335	isochorismatase
D6022_RS03615	COG0590	tRNA wobble adenosine to inosine editing
D6022_RS03625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D6022_RS03630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D6022_RS03635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D6022_RS03680	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D6022_RS03685	COG3853	Toxic anion resistance protein (TelA)
D6022_RS03690	COG1982	Orn Lys Arg decarboxylase major
D6022_RS03695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D6022_RS03700	COG3870	Protein conserved in bacteria
D6022_RS03705	COG1728	Protein conserved in bacteria
D6022_RS03710	COG0470	DNA polymerase III
D6022_RS03715	COG1774	PSP1 C-terminal conserved region
D6022_RS03720	COG4467	Involved in initiation control of chromosome replication
D6022_RS03725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D6022_RS03730	COG2827	Endonuclease containing a URI domain
D6022_RS03735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D6022_RS03740	COG2002	toxin-antitoxin pair type II binding
D6022_RS03745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6022_RS03745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6022_RS03750	COG0084	hydrolase, TatD family'
D6022_RS03755	COG3583	domain protein
D6022_RS03755	COG3584	3D domain protein
D6022_RS03760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D6022_RS03765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D6022_RS03775	COG4466	Protein conserved in bacteria
D6022_RS03785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D6022_RS03790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D6022_RS03795	COG0251	oxidation-reduction process
D6022_RS03800	COG2088	sporulation resulting in formation of a cellular spore
D6022_RS03810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D6022_RS03815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D6022_RS03820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D6022_RS03825	COG0193	aminoacyl-tRNA hydrolase activity
D6022_RS03835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D6022_RS03840	COG2002	toxin-antitoxin pair type II binding
D6022_RS03845	COG2244	polysaccharide biosynthetic process
D6022_RS03850	COG3956	TIGRFAM MazG family protein
D6022_RS03855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D6022_RS03870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D6022_RS03875	COG1098	S1 RNA binding domain
D6022_RS03890	COG2208	phosphoserine phosphatase activity
D6022_RS03895	COG2304	oxidoreductase activity
D6022_RS03900	COG0515	serine threonine protein kinase
D6022_RS03905	COG0037	tRNA processing
D6022_RS03910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D6022_RS03915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D6022_RS03920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D6022_RS03925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D6022_RS03930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D6022_RS03935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D6022_RS03945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D6022_RS03950	COG0512	Glutamine amidotransferase of anthranilate synthase
D6022_RS03955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D6022_RS03960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D6022_RS03965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D6022_RS03970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D6022_RS03975	COG1396	sequence-specific DNA binding
D6022_RS03980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D6022_RS03985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D6022_RS04065	COG4463	regulation of RNA biosynthetic process
D6022_RS04070	COG3880	PFAM UvrB UvrC protein
D6022_RS04075	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D6022_RS04080	COG0542	response to heat
D6022_RS04085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D6022_RS04090	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D6022_RS04095	COG4956	integral membrane protein (PIN domain superfamily)
D6022_RS04100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D6022_RS04105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D6022_RS04110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D6022_RS04115	COG1045	serine acetyltransferase
D6022_RS04120	COG0215	cysteine-tRNA ligase activity
D6022_RS04125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D6022_RS04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6022_RS04135	COG3688	RNA-binding protein containing a PIN domain
D6022_RS04145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6022_RS04155	COG0250	Participates in transcription elongation, termination and antitermination
D6022_RS04160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D6022_RS04165	COG0081	regulation of translation
D6022_RS04170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D6022_RS04175	COG0222	ribosome binding
D6022_RS04180	COG2813	Specifically methylates the guanine in position
D6022_RS04185	COG0085	RNA polymerase activity
D6022_RS04190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D6022_RS04195	COG1358	cellular component organization or biogenesis
D6022_RS04200	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D6022_RS04205	COG0049	tRNA binding
D6022_RS04210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D6022_RS04215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D6022_RS04225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D6022_RS04230	COG0088	Forms part of the polypeptide exit tunnel
D6022_RS04235	COG0089	rRNA binding
D6022_RS04240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D6022_RS04245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D6022_RS04250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D6022_RS04255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D6022_RS04260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D6022_RS04265	COG0255	Belongs to the universal ribosomal protein uL29 family
D6022_RS04270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D6022_RS04275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D6022_RS04280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D6022_RS04285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D6022_RS04290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6022_RS04295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D6022_RS04300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D6022_RS04305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D6022_RS04310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D6022_RS04315	COG1841	ribosomal large subunit assembly
D6022_RS04320	COG0200	Binds to the 23S rRNA
D6022_RS04325	COG0201	protein transport
D6022_RS04330	COG0563	adenylate kinase activity
D6022_RS04335	COG0024	Methionine aminopeptidase
D6022_RS04340	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D6022_RS04345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D6022_RS04350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D6022_RS04355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D6022_RS04360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D6022_RS04365	COG0202	RNA polymerase activity
D6022_RS04370	COG0203	ribosomal protein L17
D6022_RS04375	COG1122	ATPase activity
D6022_RS04380	COG1122	ATPase activity
D6022_RS04385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D6022_RS04390	COG0101	tRNA pseudouridine synthase activity
D6022_RS04395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D6022_RS04400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D6022_RS04405	COG2318	DinB family
D6022_RS04415	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS04420	COG0489	protein tyrosine kinase activity
D6022_RS04430	COG2194	sulfuric ester hydrolase activity
D6022_RS04435	COG0726	polysaccharide deacetylase
D6022_RS04465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6022_RS04475	COG0385	Bile acid
D6022_RS04490	COG3876	Protein conserved in bacteria
D6022_RS04495	COG1472	Belongs to the glycosyl hydrolase 3 family
D6022_RS04500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6022_RS04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS04505	COG1263	PTS System
D6022_RS04510	COG1737	Transcriptional regulator
D6022_RS04515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D6022_RS04520	COG1683	Conserved Protein
D6022_RS04555	COG1595	DNA-templated transcription, initiation
D6022_RS04560	COG5662	AntiSigma factor
D6022_RS04565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D6022_RS04570	COG4856	YbbR-like protein
D6022_RS04575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D6022_RS04580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6022_RS04600	COG1725	Transcriptional regulator
D6022_RS04605	COG0640	Transcriptional regulator
D6022_RS04610	COG2814	Major facilitator Superfamily
D6022_RS04620	COG1132	(ABC) transporter
D6022_RS04625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D6022_RS04650	COG1011	Hydrolase
D6022_RS04655	COG1113	amino acid transport
D6022_RS04660	COG2851	Citrate transporter
D6022_RS04665	COG3181	Tripartite tricarboxylate transporter family receptor
D6022_RS04670	COG4565	transcriptional regulatory protein
D6022_RS04675	COG3290	protein histidine kinase activity
D6022_RS04690	COG2211	Major facilitator Superfamily
D6022_RS04710	COG1331	Highly conserved protein containing a thioredoxin domain
D6022_RS04715	COG1331	Highly conserved protein containing a thioredoxin domain
D6022_RS04730	COG2856	Zn peptidase
D6022_RS04735	COG1396	sequence-specific DNA binding
D6022_RS04770	COG1674	ftsk spoiiie
D6022_RS04775	COG2946	Replication initiation factor
D6022_RS04820	COG0433	COG0433 Predicted ATPase
D6022_RS04835	COG5644	endopeptidase inhibitor activity
D6022_RS04840	COG0741	lytic transglycosylase activity
D6022_RS04840	COG0791	NLP P60 protein
D6022_RS04865	COG0457	Tetratricopeptide repeat
D6022_RS04880	COG1331	Highly conserved protein containing a thioredoxin domain
D6022_RS04890	COG0477	Major facilitator Superfamily
D6022_RS04910	COG1283	sodium-dependent phosphate transmembrane transporter activity
D6022_RS04915	COG4682	membrane
D6022_RS04940	COG0697	spore germination
D6022_RS04945	COG1917	Cupin 2, conserved barrel domain protein
D6022_RS04945	COG2207	Transcriptional regulator
D6022_RS04965	COG0371	Dehydrogenase
D6022_RS04970	COG0840	transmembrane signaling receptor activity
D6022_RS04975	COG4213	ABC transporter substrate-binding protein
D6022_RS04990	COG4257	antibiotic catabolic process
D6022_RS05000	COG0833	amino acid
D6022_RS05005	COG2040	homocysteine
D6022_RS05015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS05015	COG1263	PTS System
D6022_RS05015	COG2190	(PTS) system
D6022_RS05020	COG0789	Transcriptional regulator
D6022_RS05025	COG2323	membrane
D6022_RS05030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D6022_RS05030	COG4451	ribulose bisphosphate carboxylase, small
D6022_RS05040	COG2205	protein histidine kinase activity
D6022_RS05045	COG1115	amino acid carrier protein
D6022_RS05050	COG2066	Belongs to the glutaminase family
D6022_RS05055	COG4191	Histidine kinase
D6022_RS05060	COG0784	Response regulator, receiver
D6022_RS05085	COG3540	Alkaline phosphatase
D6022_RS05090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6022_RS05095	COG0805	protein transport
D6022_RS05100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6022_RS05105	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS05110	COG2271	Major facilitator Superfamily
D6022_RS05115	COG4948	Mandelate Racemase Muconate Lactonizing
D6022_RS05120	COG2186	Transcriptional regulator
D6022_RS05125	COG2721	sulfolactate sulfo-lyase activity
D6022_RS05130	COG0745	RESPONSE REGULATOR receiver
D6022_RS05135	COG2205	protein histidine kinase activity
D6022_RS05140	COG1131	(ABC) transporter
D6022_RS05165	COG3173	Aminoglycoside phosphotransferase
D6022_RS05170	COG1846	Transcriptional regulator
D6022_RS05175	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS05195	COG0789	Transcriptional regulator
D6022_RS05220	COG0697	spore germination
D6022_RS05225	COG1714	RDD family
D6022_RS05230	COG1405	negative regulation of cell septum assembly
D6022_RS05230	COG3012	SEC-C Motif Domain Protein
D6022_RS05235	COG1131	(ABC) transporter
D6022_RS05260	COG0583	DNA-binding transcription factor activity
D6022_RS05265	COG1942	4-Oxalocrotonate Tautomerase
D6022_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS05285	COG1288	antiporter activity
D6022_RS05295	COG0456	acetyltransferase
D6022_RS05305	COG1164	Oligoendopeptidase f
D6022_RS05310	COG2261	transglycosylase associated protein
D6022_RS05320	COG0247	lactate metabolic process
D6022_RS05325	COG0277	FAD linked oxidase domain protein
D6022_RS05330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS05335	COG1447	Phosphotransferase system cellobiose-specific component IIA
D6022_RS05340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS05345	COG1486	melibiose metabolic process
D6022_RS05350	COG2188	Transcriptional regulator
D6022_RS05355	COG3394	polysaccharide catabolic process
D6022_RS05370	COG3591	Belongs to the peptidase S1B family
D6022_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS05385	COG1595	DNA-templated transcription, initiation
D6022_RS05395	COG3773	Cell wall hydrolase
D6022_RS05400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6022_RS05415	COG1131	(ABC) transporter
D6022_RS05420	COG1309	transcriptional regulator
D6022_RS05440	COG2310	stress, protein
D6022_RS05445	COG2310	stress, protein
D6022_RS05455	COG0861	Integral membrane protein TerC family
D6022_RS05475	COG3853	Toxic anion resistance protein (TelA)
D6022_RS05480	COG0785	Cytochrome C biogenesis protein
D6022_RS05490	COG0789	Transcriptional regulator
D6022_RS05495	COG2223	nitrite transmembrane transporter activity
D6022_RS05500	COG0039	L-malate dehydrogenase activity
D6022_RS05505	COG1620	l-lactate permease
D6022_RS05510	COG1280	lysine exporter protein (LysE YggA)
D6022_RS05515	COG1113	amino acid transport
D6022_RS05520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D6022_RS05525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D6022_RS05530	COG3541	Predicted nucleotidyltransferase
D6022_RS05535	COG0506	proline dehydrogenase activity
D6022_RS05540	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS05545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS05550	COG2508	Transcriptional regulator
D6022_RS05555	COG3689	TIGRFAM TIGR03943 family protein
D6022_RS05560	COG0701	Predicted permease
D6022_RS05565	COG3458	cephalosporin-C deacetylase activity
D6022_RS05585	COG0765	amino acid transport
D6022_RS05590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6022_RS05605	COG2723	6-phospho-beta-galactosidase activity
D6022_RS05615	COG3209	COG3209 Rhs family protein
D6022_RS05620	COG0515	serine threonine protein kinase
D6022_RS05620	COG3266	domain, Protein
D6022_RS05630	COG5444	nuclease activity
D6022_RS05655	COG1176	ABC-type spermidine putrescine transport system, permease component I
D6022_RS05660	COG1177	transmembrane transport
D6022_RS05665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6022_RS05670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6022_RS05675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6022_RS05680	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D6022_RS05685	COG0697	spore germination
D6022_RS05690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6022_RS05700	COG2819	hydrolase of the alpha beta superfamily
D6022_RS05710	COG2364	Membrane
D6022_RS05720	COG1131	(ABC) transporter
D6022_RS05745	COG1126	abc transporter atp-binding protein
D6022_RS05750	COG0765	amino acid transport
D6022_RS05755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6022_RS05760	COG3829	transcription factor binding
D6022_RS05765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D6022_RS05770	COG0833	amino acid
D6022_RS05775	COG0010	Belongs to the arginase family
D6022_RS05780	COG0583	DNA-binding transcription factor activity
D6022_RS05785	COG0163	prenyltransferase activity
D6022_RS05790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D6022_RS05840	COG5444	nuclease activity
D6022_RS05860	COG2972	Histidine kinase
D6022_RS05865	COG2207	Transcriptional regulator
D6022_RS05865	COG4753	response regulator
D6022_RS05870	COG4213	ABC transporter substrate-binding protein
D6022_RS05880	COG4214	carbohydrate transport
D6022_RS05885	COG2271	Major facilitator Superfamily
D6022_RS05890	COG0456	acetyltransferase
D6022_RS05890	COG1846	Transcriptional regulator
D6022_RS05895	COG1874	Beta-galactosidase
D6022_RS05900	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D6022_RS05905	COG3104	oligopeptide transport
D6022_RS05910	COG5434	Belongs to the glycosyl hydrolase 28 family
D6022_RS05920	COG0697	spore germination
D6022_RS05930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D6022_RS05935	COG0789	Transcriptional regulator
D6022_RS05940	COG1136	(ABC) transporter
D6022_RS05945	COG0577	efflux transmembrane transporter activity
D6022_RS05950	COG0745	RESPONSE REGULATOR receiver
D6022_RS05955	COG5002	protein histidine kinase activity
D6022_RS05955	COG3850	Histidine kinase
D6022_RS05965	COG0527	aspartate kinase activity
D6022_RS05970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS05980	COG4604	ABC transporter, ATP-binding protein
D6022_RS05985	COG4607	ABC-type enterochelin transport system periplasmic component
D6022_RS05990	COG2814	Major facilitator Superfamily
D6022_RS05995	COG1309	transcriptional regulator
D6022_RS06005	COG0778	Nitroreductase
D6022_RS06010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D6022_RS06015	COG0640	Transcriptional regulator
D6022_RS06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6022_RS06025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D6022_RS06030	COG0531	amino acid
D6022_RS06035	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS06050	COG4549	nuclear export factor GLE1
D6022_RS06055	COG1276	copper resistance
D6022_RS06055	COG2372	response to copper ion
D6022_RS06060	COG1349	DNA-binding transcription factor activity
D6022_RS06065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6022_RS06070	COG0243	molybdopterin cofactor binding
D6022_RS06075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6022_RS06080	COG2146	nitrite reductase [NAD(P)H] activity
D6022_RS06085	COG1587	Uroporphyrinogen-III synthase
D6022_RS06085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6022_RS06090	COG1802	Transcriptional regulator
D6022_RS06095	COG0471	metal ion transport
D6022_RS06100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D6022_RS06105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D6022_RS06120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS06135	COG3959	Transketolase, thiamine diphosphate binding domain
D6022_RS06140	COG3958	Transketolase
D6022_RS06145	COG0561	phosphatase activity
D6022_RS06150	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D6022_RS06155	COG1914	H( )-stimulated, divalent metal cation uptake system
D6022_RS06160	COG4336	lyase activity
D6022_RS06165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D6022_RS06170	COG1984	allophanate hydrolase subunit 2
D6022_RS06175	COG1414	Transcriptional regulator
D6022_RS06180	COG2755	lipolytic protein G-D-S-L family
D6022_RS06185	COG2213	PTS system mannitol-specific
D6022_RS06190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS06195	COG0246	Mannitol dehydrogenase
D6022_RS06200	COG3711	transcriptional antiterminator
D6022_RS06205	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS06210	COG1917	Cupin 2, conserved barrel domain protein
D6022_RS06220	COG3871	stress protein (general stress protein 26)
D6022_RS06235	COG2814	Major facilitator Superfamily
D6022_RS06245	COG1522	sequence-specific DNA binding
D6022_RS06250	COG0551	DNA topoisomerase type I activity
D6022_RS06250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D6022_RS06255	COG0531	amino acid
D6022_RS06260	COG0028	Belongs to the TPP enzyme family
D6022_RS06265	COG3397	chitin binding
D6022_RS06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS06280	COG1914	H( )-stimulated, divalent metal cation uptake system
D6022_RS06285	COG2261	transglycosylase associated protein
D6022_RS06290	COG1027	Aspartate ammonia-lyase
D6022_RS06295	COG1819	glycosyl
D6022_RS06300	COG4876	unkown
D6022_RS06305	COG2217	Heavy metal translocating P-type atpase
D6022_RS06315	COG0662	Cupin 2, conserved barrel domain protein
D6022_RS06320	COG3729	General stress protein
D6022_RS06325	COG0628	permease
D6022_RS06330	COG1301	dicarboxylic acid transport
D6022_RS06335	COG1131	(ABC) transporter
D6022_RS06340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D6022_RS06350	COG1960	acyl-CoA dehydrogenase activity
D6022_RS06365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS06370	COG1181	Belongs to the D-alanine--D-alanine ligase family
D6022_RS06375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D6022_RS06385	COG0513	Belongs to the DEAD box helicase family
D6022_RS06390	COG3402	PFAM membrane-flanked domain
D6022_RS06395	COG3428	Bacterial PH domain
D6022_RS06400	COG0705	Rhomboid family
D6022_RS06405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D6022_RS06410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D6022_RS06415	COG0864	Transcriptional regulator
D6022_RS06420	COG2337	Toxic component of a toxin-antitoxin (TA) module
D6022_RS06425	COG1366	Belongs to the anti-sigma-factor antagonist family
D6022_RS06430	COG1366	Belongs to the anti-sigma-factor antagonist family
D6022_RS06435	COG2172	sigma factor antagonist activity
D6022_RS06440	COG2208	phosphoserine phosphatase activity
D6022_RS06450	COG2172	sigma factor antagonist activity
D6022_RS06455	COG1191	sigma factor activity
D6022_RS06460	COG2208	phosphoserine phosphatase activity
D6022_RS06465	COG2183	response to ionizing radiation
D6022_RS06470	COG1309	transcriptional regulator
D6022_RS06475	COG1033	growth of symbiont in host cell
D6022_RS06475	COG2409	Drug exporters of the RND superfamily
D6022_RS06485	COG3091	SprT-like family
D6022_RS06535	COG1476	TRANSCRIPTIONal
D6022_RS06540	COG3239	Fatty acid desaturase
D6022_RS06545	COG1278	Cold shock
D6022_RS06550	COG1063	alcohol dehydrogenase
D6022_RS06560	COG2364	Membrane
D6022_RS06570	COG0456	acetyltransferase
D6022_RS06575	COG2808	Putative FMN-binding domain
D6022_RS06585	COG1733	regulation of RNA biosynthetic process
D6022_RS06590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS06600	COG0583	DNA-binding transcription factor activity
D6022_RS06615	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D6022_RS06620	COG1113	amino acid transport
D6022_RS06635	COG1595	DNA-templated transcription, initiation
D6022_RS06645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D6022_RS06645	COG2755	lipolytic protein G-D-S-L family
D6022_RS06650	COG2814	Major facilitator Superfamily
D6022_RS06655	COG0745	RESPONSE REGULATOR receiver
D6022_RS06655	COG2972	Histidine kinase
D6022_RS06660	COG3279	Response regulator of the LytR AlgR family
D6022_RS06670	COG3764	Sortase (surface protein transpeptidase)
D6022_RS06675	COG2814	Major facilitator Superfamily
D6022_RS06715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D6022_RS06720	COG0802	atpase or kinase
D6022_RS06725	COG1214	PFAM Peptidase M22, glycoprotease
D6022_RS06730	COG0456	acetyltransferase
D6022_RS06735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D6022_RS06740	COG0488	(ABC) transporter
D6022_RS06745	COG0315	cyclic pyranopterin monophosphate synthase activity
D6022_RS06750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D6022_RS06755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6022_RS06760	COG0805	protein transport
D6022_RS06770	COG1266	CAAX protease self-immunity
D6022_RS06775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D6022_RS06780	COG0459	protein refolding
D6022_RS06785	COG4974	Belongs to the 'phage' integrase family
D6022_RS06790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D6022_RS06815	COG3646	Phage regulatory protein
D6022_RS06910	COG0582	viral genome integration into host DNA
D6022_RS07070	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS07075	COG1621	beta-fructofuranosidase activity
D6022_RS07080	COG1621	beta-fructofuranosidase activity
D6022_RS07085	COG1902	pentaerythritol trinitrate reductase activity
D6022_RS07100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6022_RS07115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D6022_RS07125	COG2271	Major facilitator Superfamily
D6022_RS07130	COG2249	NAD(P)H dehydrogenase (quinone) activity
D6022_RS07140	COG0438	transferase activity, transferring glycosyl groups
D6022_RS07145	COG1215	transferase activity, transferring glycosyl groups
D6022_RS07150	COG0438	transferase activity, transferring glycosyl groups
D6022_RS07160	COG1216	Glycosyl transferase, family 2
D6022_RS07165	COG5039	Polysaccharide pyruvyl transferase
D6022_RS07170	COG1216	Glycosyl transferase, family 2
D6022_RS07180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D6022_RS07185	COG0110	maltose O-acetyltransferase activity
D6022_RS07190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6022_RS07195	COG5039	Polysaccharide pyruvyl transferase
D6022_RS07205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D6022_RS07210	COG1620	l-lactate permease
D6022_RS07215	COG2186	Transcriptional regulator
D6022_RS07220	COG0247	lactate metabolic process
D6022_RS07225	COG1139	Iron-sulfur cluster binding protein
D6022_RS07230	COG1556	Lactate utilization protein
D6022_RS07250	COG1113	amino acid transport
D6022_RS07255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6022_RS07260	COG2390	Transcriptional regulator
D6022_RS07265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D6022_RS07275	COG0126	phosphoglycerate kinase activity
D6022_RS07280	COG0149	triose-phosphate isomerase activity
D6022_RS07285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D6022_RS07290	COG0148	phosphopyruvate hydratase activity
D6022_RS07295	COG0693	protein deglycase activity
D6022_RS07310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS07315	COG4640	response to antibiotic
D6022_RS07325	COG2095	MarC family integral membrane protein
D6022_RS07330	COG1510	regulation of RNA biosynthetic process
D6022_RS07335	COG1125	glycine betaine transport
D6022_RS07335	COG0517	IMP dehydrogenase activity
D6022_RS07340	COG1174	glycine betaine transport
D6022_RS07345	COG1732	Glycine betaine
D6022_RS07350	COG1174	glycine betaine transport
D6022_RS07355	COG1396	sequence-specific DNA binding
D6022_RS07360	COG1396	sequence-specific DNA binding
D6022_RS07365	COG1476	TRANSCRIPTIONal
D6022_RS07370	COG2002	toxin-antitoxin pair type II binding
D6022_RS07375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D6022_RS07380	COG1647	Serine aminopeptidase, S33
D6022_RS07385	COG0557	exoribonuclease II activity
D6022_RS07390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D6022_RS07425	COG2140	Oxalate decarboxylase
D6022_RS07435	COG1191	sigma factor activity
D6022_RS07445	COG1054	Belongs to the UPF0176 family
D6022_RS07450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D6022_RS07455	COG0673	inositol 2-dehydrogenase activity
D6022_RS07465	COG1846	Transcriptional regulator
D6022_RS07475	COG2124	cytochrome p450
D6022_RS07485	COG2814	Major facilitator Superfamily
D6022_RS07490	COG2814	Major facilitator Superfamily
D6022_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS07495	COG3347	Dehydrogenase
D6022_RS07505	COG4952	isomerase
D6022_RS07510	COG1070	Carbohydrate kinase
D6022_RS07515	COG1349	DNA-binding transcription factor activity
D6022_RS07520	COG0693	protein deglycase activity
D6022_RS07525	COG1937	Protein conserved in bacteria
D6022_RS07530	COG2608	mercury ion transmembrane transporter activity
D6022_RS07535	COG2217	Heavy metal translocating P-type atpase
D6022_RS07550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS07550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS07550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS07555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D6022_RS07555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D6022_RS07570	COG0803	Belongs to the bacterial solute-binding protein 9 family
D6022_RS07575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D6022_RS07580	COG1121	(ABC) transporter
D6022_RS07585	COG1472	Belongs to the glycosyl hydrolase 3 family
D6022_RS07590	COG1501	Belongs to the glycosyl hydrolase 31 family
D6022_RS07595	COG0395	ABC-type sugar transport system, permease component
D6022_RS07600	COG1175	transmembrane transport
D6022_RS07610	COG2217	Heavy metal translocating P-type atpase
D6022_RS07615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D6022_RS07620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D6022_RS07625	COG0456	acetyltransferase
D6022_RS07630	COG0456	acetyltransferase
D6022_RS07630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D6022_RS07635	COG2860	membrane
D6022_RS07640	COG3973	AAA domain
D6022_RS07650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D6022_RS07655	COG1940	carbohydrate kinase activity
D6022_RS07660	COG0656	L-ascorbic acid biosynthetic process
D6022_RS07670	COG2814	Major facilitator Superfamily
D6022_RS07675	COG1368	sulfuric ester hydrolase activity
D6022_RS07680	COG1988	membrane-bound metal-dependent
D6022_RS07690	COG0531	amino acid
D6022_RS07695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS07705	COG1120	ATPase activity
D6022_RS07710	COG0745	RESPONSE REGULATOR receiver
D6022_RS07715	COG2205	protein histidine kinase activity
D6022_RS07720	COG1904	glucuronate isomerase
D6022_RS07725	COG2211	Major facilitator Superfamily
D6022_RS07730	COG1609	Transcriptional regulator
D6022_RS07735	COG0246	Mannitol dehydrogenase
D6022_RS07740	COG2721	sulfolactate sulfo-lyase activity
D6022_RS07750	COG0583	DNA-binding transcription factor activity
D6022_RS07755	COG2258	MOSC domain
D6022_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS07765	COG1802	Transcriptional regulator
D6022_RS07770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS07775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS07780	COG1120	ATPase activity
D6022_RS07785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6022_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS07810	COG2096	Adenosyltransferase
D6022_RS07815	COG4677	pectinesterase activity
D6022_RS07820	COG4758	membrane
D6022_RS07825	COG1842	Phage shock protein A
D6022_RS07835	COG4758	membrane
D6022_RS07840	COG4585	Histidine kinase
D6022_RS07845	COG2197	response regulator
D6022_RS07860	COG0814	amino acid
D6022_RS07865	COG0697	spore germination
D6022_RS07875	COG0114	fumarate hydratase activity
D6022_RS07880	COG1309	transcriptional regulator
D6022_RS07885	COG2770	Histidine kinase
D6022_RS07885	COG2205	protein histidine kinase activity
D6022_RS07890	COG0745	RESPONSE REGULATOR receiver
D6022_RS07895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6022_RS07900	COG0783	Belongs to the Dps family
D6022_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS07910	COG1686	Belongs to the peptidase S11 family
D6022_RS07925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS07930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS07935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS07940	COG1120	ATPase activity
D6022_RS07955	COG5577	PFAM Coat F domain
D6022_RS07970	COG1024	Enoyl-CoA hydratase
D6022_RS07970	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6022_RS07975	COG0183	Belongs to the thiolase family
D6022_RS07980	COG1960	acyl-CoA dehydrogenase activity
D6022_RS07985	COG1393	Belongs to the ArsC family
D6022_RS07990	COG0509	glycine decarboxylation via glycine cleavage system
D6022_RS08000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D6022_RS08005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS08015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D6022_RS08020	COG2011	ABC-type metal ion transport system permease component
D6022_RS08025	COG1464	Belongs to the NlpA lipoprotein family
D6022_RS08030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6022_RS08040	COG0396	ATPase activity
D6022_RS08045	COG0719	Fe-S assembly protein
D6022_RS08050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D6022_RS08055	COG0822	iron-sulfur transferase activity
D6022_RS08060	COG0719	Fe-S assembly protein
D6022_RS08065	COG0457	Tetratricopeptide repeat
D6022_RS08080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6022_RS08090	COG2356	endonuclease I
D6022_RS08095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6022_RS08100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6022_RS08105	COG1288	antiporter activity
D6022_RS08110	COG2814	Major facilitator Superfamily
D6022_RS08115	COG2508	Transcriptional regulator
D6022_RS08120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6022_RS08125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D6022_RS08135	COG3226	Transcriptional regulator
D6022_RS08145	COG1801	Protein of unknown function DUF72
D6022_RS08150	COG0730	response to heat
D6022_RS08155	COG0737	Belongs to the 5'-nucleotidase family
D6022_RS08160	COG3377	Domain of unknown function (DUF1805)
D6022_RS08170	COG0733	neurotransmitter:sodium symporter activity
D6022_RS08180	COG0739	heme binding
D6022_RS08195	COG4470	Protein conserved in bacteria
D6022_RS08200	COG2445	Protein of unknown function DUF86
D6022_RS08205	COG0647	UMP catabolic process
D6022_RS08210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D6022_RS08215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D6022_RS08225	COG0460	homoserine dehydrogenase
D6022_RS08230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D6022_RS08235	COG0083	homoserine kinase activity
D6022_RS08240	COG4946	Tricorn protease homolog
D6022_RS08240	COG1506	peptidase
D6022_RS08240	COG0823	Involved in the tonB-independent uptake of proteins
D6022_RS08245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D6022_RS08250	COG4837	Protein of unknown function (DUF1462)
D6022_RS08260	COG3479	Phenolic acid decarboxylase
D6022_RS08265	COG0457	Tetratricopeptide repeat
D6022_RS08275	COG5646	InterPro IPR014922
D6022_RS08280	COG1252	NADH dehydrogenase
D6022_RS08285	COG4844	belongs to the
D6022_RS08290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D6022_RS08295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D6022_RS08300	COG0316	Belongs to the HesB IscA family
D6022_RS08305	COG0456	acetyltransferase
D6022_RS08320	COG0492	ferredoxin-NADP+ reductase activity
D6022_RS08325	COG1252	NADH dehydrogenase
D6022_RS08335	COG3584	3D domain protein
D6022_RS08340	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D6022_RS08345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D6022_RS08350	COG2056	Na+-H+ antiporter family
D6022_RS08355	COG1268	BioY protein
D6022_RS08360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D6022_RS08370	COG0686	Belongs to the AlaDH PNT family
D6022_RS08375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D6022_RS08375	COG2508	Transcriptional regulator
D6022_RS08380	COG1115	amino acid carrier protein
D6022_RS08385	COG4842	Belongs to the WXG100 family
D6022_RS08390	COG5417	Belongs to the EsaB family
D6022_RS08395	COG4499	WXG100 protein secretion system (Wss), protein YukC
D6022_RS08400	COG0433	COG0433 Predicted ATPase
D6022_RS08400	COG1674	ftsk spoiiie
D6022_RS08405	COG1511	domain protein
D6022_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS08420	COG1418	mRNA catabolic process
D6022_RS08435	COG1959	2 iron, 2 sulfur cluster binding
D6022_RS08440	COG0628	permease
D6022_RS08455	COG5506	Protein of unknown function (DUF1694)
D6022_RS08460	COG1335	isochorismatase
D6022_RS08465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D6022_RS08470	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D6022_RS08500	COG4585	Histidine kinase
D6022_RS08505	COG2197	response regulator
D6022_RS08510	COG2050	protein possibly involved in aromatic compounds catabolism
D6022_RS08515	COG1320	monovalent cation:proton antiporter activity
D6022_RS08520	COG2212	antiporter activity
D6022_RS08525	COG1863	multisubunit Na H antiporter MnhE subunit
D6022_RS08530	COG0651	ATP synthesis coupled electron transport
D6022_RS08535	COG1006	Multisubunit Na H antiporter MnhC subunit
D6022_RS08540	COG2111	Na H antiporter
D6022_RS08545	COG2111	Na H antiporter
D6022_RS08545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6022_RS08555	COG3493	citrate carrier protein
D6022_RS08560	COG0688	phosphatidylethanolamine metabolic process
D6022_RS08565	COG0586	Pfam SNARE associated Golgi protein
D6022_RS08570	COG1183	phosphatidylcholine synthase activity
D6022_RS08580	COG4565	transcriptional regulatory protein
D6022_RS08585	COG3290	protein histidine kinase activity
D6022_RS08595	COG3011	Protein conserved in bacteria
D6022_RS08600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6022_RS08605	COG2814	Major facilitator Superfamily
D6022_RS08610	COG5018	Exonuclease
D6022_RS08625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D6022_RS08640	COG2267	carboxylic ester hydrolase activity
D6022_RS08645	COG1522	sequence-specific DNA binding
D6022_RS08650	COG0436	Aminotransferase
D6022_RS08655	COG1098	S1 RNA binding domain
D6022_RS08660	COG2155	Conserved Protein
D6022_RS08665	COG1979	alcohol dehydrogenase
D6022_RS08670	COG0166	Belongs to the GPI family
D6022_RS08805	COG4626	Terminase
D6022_RS08805	COG1802	Transcriptional regulator
D6022_RS08940	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D6022_RS08945	COG2323	membrane
D6022_RS08955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D6022_RS08970	COG2738	Putative neutral zinc metallopeptidase
D6022_RS08975	COG1253	flavin adenine dinucleotide binding
D6022_RS08980	COG5297	Belongs to the glycosyl hydrolase family 6
D6022_RS08995	COG0366	Alpha amylase catalytic
D6022_RS09000	COG0432	Pfam Uncharacterised protein family UPF0047
D6022_RS09005	COG2070	2-Nitropropane dioxygenase
D6022_RS09015	COG0840	transmembrane signaling receptor activity
D6022_RS09020	COG0840	transmembrane signaling receptor activity
D6022_RS09025	COG0840	transmembrane signaling receptor activity
D6022_RS09030	COG0693	protein deglycase activity
D6022_RS09035	COG0673	inositol 2-dehydrogenase activity
D6022_RS09040	COG0628	permease
D6022_RS09045	COG1968	undecaprenyl-diphosphatase activity
D6022_RS09050	COG1408	metallophosphoesterase
D6022_RS09055	COG0726	polysaccharide deacetylase
D6022_RS09060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6022_RS09070	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D6022_RS09105	COG1397	ADP-ribosylglycohydrolase
D6022_RS09135	COG1476	TRANSCRIPTIONal
D6022_RS09175	COG5377	YqaJ viral recombinase family
D6022_RS09180	COG3723	Recombinational DNA repair protein, rece pathway
D6022_RS09195	COG0305	Participates in initiation and elongation during chromosome replication
D6022_RS09210	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D6022_RS09255	COG0457	Tetratricopeptide repeat
D6022_RS09295	COG1783	phage Terminase large subunit
D6022_RS09300	COG5518	Phage portal protein
D6022_RS09305	COG2369	cell adhesion
D6022_RS09315	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D6022_RS09320	COG4653	Phage capsid family
D6022_RS09380	COG3953	SLT domain
D6022_RS09380	COG5280	Phage tail tape measure protein TP901
D6022_RS09380	COG3953	SLT domain
D6022_RS09380	COG5280	Phage tail tape measure protein TP901
D6022_RS09385	COG1652	LysM domain
D6022_RS09390	COG4193	domain, Protein
D6022_RS09400	COG3628	GPW Gp25 family protein
D6022_RS09405	COG3299	homolog of phage Mu protein gp47
D6022_RS09410	COG3778	Protein conserved in bacteria
D6022_RS09460	COG1793	dna ligase
D6022_RS09490	COG2140	Oxalate decarboxylase
D6022_RS09495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D6022_RS09500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D6022_RS09510	COG1510	regulation of RNA biosynthetic process
D6022_RS09515	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS09520	COG1454	alcohol dehydrogenase
D6022_RS09530	COG2318	DinB family
D6022_RS09540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D6022_RS09545	COG0569	domain protein
D6022_RS09550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D6022_RS09555	COG0457	Tetratricopeptide repeat
D6022_RS09570	COG3764	Sortase (surface protein transpeptidase)
D6022_RS09575	COG3859	Proton-coupled thiamine transporter YuaJ
D6022_RS09705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D6022_RS09710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D6022_RS09715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D6022_RS09720	COG0297	glycogen (starch) synthase activity
D6022_RS09725	COG0058	SHG alpha-glucan phosphorylase activity
D6022_RS09730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D6022_RS09735	COG1575	Belongs to the MenA family. Type 1 subfamily
D6022_RS09740	COG1169	isochorismate synthase
D6022_RS09745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D6022_RS09750	COG0596	Alpha beta hydrolase
D6022_RS09755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D6022_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS09765	COG4948	Mandelate Racemase Muconate Lactonizing
D6022_RS09780	COG1294	oxidase, subunit
D6022_RS09785	COG1271	oxidase subunit
D6022_RS09790	COG0254	rRNA binding
D6022_RS09795	COG0803	Belongs to the bacterial solute-binding protein 9 family
D6022_RS09800	COG0523	cobalamin synthesis protein
D6022_RS09805	COG0288	reversible hydration of carbon dioxide
D6022_RS09810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D6022_RS09815	COG1854	S-ribosylhomocysteine lyase activity
D6022_RS09830	COG0783	Belongs to the Dps family
D6022_RS09835	COG4824	toxin secretion phage lysis holin
D6022_RS09845	COG0494	nUDIX hydrolase
D6022_RS09850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6022_RS09855	COG1116	anion transmembrane transporter activity
D6022_RS09860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D6022_RS09865	COG1506	peptidase
D6022_RS09880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D6022_RS09885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D6022_RS09890	COG0367	asparagine synthase
D6022_RS09895	COG0438	transferase activity, transferring glycosyl groups
D6022_RS09895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6022_RS09900	COG0671	phosphoesterase, PA-phosphatase related
D6022_RS09905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D6022_RS09910	COG2267	carboxylic ester hydrolase activity
D6022_RS09920	COG1301	dicarboxylic acid transport
D6022_RS09925	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D6022_RS09930	COG1242	4 iron, 4 sulfur cluster binding
D6022_RS09940	COG1725	Transcriptional regulator
D6022_RS09945	COG1131	(ABC) transporter
D6022_RS09955	COG1136	(ABC) transporter
D6022_RS09960	COG0577	efflux transmembrane transporter activity
D6022_RS09965	COG2433	Pfam Transposase IS66
D6022_RS09975	COG2814	Major facilitator Superfamily
D6022_RS09985	COG0495	leucyl-tRNA aminoacylation
D6022_RS09990	COG0346	lactoylglutathione lyase activity
D6022_RS09995	COG0583	DNA-binding transcription factor activity
D6022_RS10005	COG1073	alpha beta
D6022_RS10010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6022_RS10015	COG0395	ABC-type sugar transport system, permease component
D6022_RS10020	COG1653	transport
D6022_RS10025	COG2207	Transcriptional regulator
D6022_RS10030	COG4209	transmembrane transport
D6022_RS10035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6022_RS10040	COG1653	transport
D6022_RS10045	COG0673	inositol 2-dehydrogenase activity
D6022_RS10050	COG5578	integral membrane protein
D6022_RS10060	COG0457	Tetratricopeptide repeat
D6022_RS10065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6022_RS10075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D6022_RS10080	COG2081	HI0933 family
D6022_RS10085	COG2244	polysaccharide biosynthetic process
D6022_RS10090	COG1187	pseudouridine synthase activity
D6022_RS10095	COG1349	DNA-binding transcription factor activity
D6022_RS10100	COG2252	PERMEase
D6022_RS10105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6022_RS10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D6022_RS10125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D6022_RS10135	COG1597	lipid kinase activity
D6022_RS10140	COG1523	belongs to the glycosyl hydrolase 13 family
D6022_RS10145	COG0510	thiamine kinase activity
D6022_RS10155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D6022_RS10160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS10165	COG0281	malic enzyme
D6022_RS10170	COG5584	Small secreted protein
D6022_RS10175	COG1363	Peptidase, m42
D6022_RS10185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS10190	COG4848	Belongs to the UPF0354 family
D6022_RS10195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6022_RS10200	COG1674	ftsk spoiiie
D6022_RS10205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D6022_RS10210	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D6022_RS10215	COG4980	gas vesicle protein
D6022_RS10220	COG3118	belongs to the thioredoxin family
D6022_RS10230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D6022_RS10230	COG1605	Chorismate mutase
D6022_RS10235	COG1609	Transcriptional regulator
D6022_RS10240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D6022_RS10245	COG1360	Flagellar Motor Protein
D6022_RS10250	COG0123	including yeast histone deacetylase and acetoin utilization protein
D6022_RS10255	COG0517	IMP dehydrogenase activity
D6022_RS10260	COG0454	-acetyltransferase
D6022_RS10265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6022_RS10270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D6022_RS10275	COG1522	sequence-specific DNA binding
D6022_RS10280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D6022_RS10285	COG3152	Membrane
D6022_RS10300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D6022_RS10310	COG1956	GAF domain-containing protein
D6022_RS10315	COG1309	transcriptional regulator
D6022_RS10320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D6022_RS10325	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D6022_RS10330	COG1114	Component of the transport system for branched-chain amino acids
D6022_RS10335	COG1104	cysteine desulfurase activity
D6022_RS10340	COG0301	tRNA thio-modification
D6022_RS10350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6022_RS10360	COG0477	Major facilitator Superfamily
D6022_RS10365	COG1566	PFAM secretion protein HlyD family protein
D6022_RS10370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D6022_RS10375	COG0616	signal peptide processing
D6022_RS10380	COG1714	RDD family
D6022_RS10390	COG3874	Sporulation protein YtfJ
D6022_RS10395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D6022_RS10400	COG0827	DNA restriction-modification system
D6022_RS10405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D6022_RS10410	COG0521	Mo-molybdopterin cofactor biosynthetic process
D6022_RS10415	COG0137	argininosuccinate synthase activity
D6022_RS10420	COG0165	Argininosuccinate lyase
D6022_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS10430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D6022_RS10435	COG1695	Transcriptional regulator
D6022_RS10440	COG4109	DRTGG domain
D6022_RS10450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D6022_RS10470	COG0587	DNA-directed DNA polymerase activity
D6022_RS10475	COG0281	malic enzyme
D6022_RS10480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D6022_RS10485	COG0825	malonyl-CoA metabolic process
D6022_RS10490	COG0205	6-phosphofructokinase activity
D6022_RS10500	COG3030	protein affecting phage T7 exclusion by the F plasmid
D6022_RS10505	COG0628	permease
D6022_RS10510	COG2707	UPF0756 membrane protein
D6022_RS10515	COG0372	Belongs to the citrate synthase family
D6022_RS10520	COG0538	isocitrate dehydrogenase activity
D6022_RS10525	COG0039	L-malate dehydrogenase activity
D6022_RS10530	COG0745	RESPONSE REGULATOR receiver
D6022_RS10535	COG5002	protein histidine kinase activity
D6022_RS10540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6022_RS10540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6022_RS10545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D6022_RS10550	COG1971	Probably functions as a manganese efflux pump
D6022_RS10555	COG0237	dephospho-CoA kinase activity
D6022_RS10560	COG3866	Pectate lyase
D6022_RS10565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D6022_RS10570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D6022_RS10585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D6022_RS10590	COG3611	Membrane attachment protein
D6022_RS10595	COG1484	DNA-dependent DNA replication
D6022_RS10600	COG0398	Pfam SNARE associated Golgi protein
D6022_RS10610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D6022_RS10615	COG1011	Hydrolase
D6022_RS10625	COG3275	phosphorelay sensor kinase activity
D6022_RS10630	COG3279	Response regulator of the LytR AlgR family
D6022_RS10635	COG3540	Alkaline phosphatase
D6022_RS10645	COG1346	cytolysis
D6022_RS10650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D6022_RS10655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D6022_RS10660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D6022_RS10665	COG3326	Membrane
D6022_RS10675	COG1363	Peptidase, m42
D6022_RS10680	COG3507	Belongs to the glycosyl hydrolase 43 family
D6022_RS10685	COG2160	L-arabinose isomerase activity
D6022_RS10695	COG0235	Class ii aldolase
D6022_RS10700	COG0371	Dehydrogenase
D6022_RS10705	COG1653	transport
D6022_RS10710	COG1175	transmembrane transport
D6022_RS10715	COG0395	ABC-type sugar transport system, permease component
D6022_RS10730	COG1966	Carbon starvation protein
D6022_RS10740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6022_RS10745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D6022_RS10750	COG0072	phenylalanine-tRNA ligase activity
D6022_RS10750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6022_RS10765	COG1137	ATPase activity
D6022_RS10795	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D6022_RS10800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D6022_RS10805	COG1286	toxin biosynthetic process
D6022_RS10810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D6022_RS10810	COG1796	DNA polymerase
D6022_RS10815	COG1193	negative regulation of DNA recombination
D6022_RS10820	COG3766	membrane
D6022_RS10825	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS10830	COG1309	transcriptional regulator
D6022_RS10835	COG1024	Enoyl-CoA hydratase
D6022_RS10840	COG2086	electron transfer activity
D6022_RS10845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D6022_RS10850	COG3118	belongs to the thioredoxin family
D6022_RS10855	COG0322	excinuclease ABC activity
D6022_RS10865	COG0527	aspartate kinase activity
D6022_RS10870	COG1719	4-vinyl reductase, 4VR
D6022_RS10875	COG2009	succinate dehydrogenase
D6022_RS10880	COG1053	succinate dehydrogenase
D6022_RS10885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D6022_RS10890	COG0824	Thioesterase
D6022_RS10895	COG4221	oxidoreductase activity
D6022_RS10900	COG2197	response regulator
D6022_RS10905	COG1846	Transcriptional regulator
D6022_RS10910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D6022_RS10915	COG5401	PFAM Sporulation and spore germination
D6022_RS10920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D6022_RS10925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D6022_RS10930	COG0622	Phosphoesterase
D6022_RS10950	COG0457	Tetratricopeptide repeat
D6022_RS10955	COG5444	nuclease activity
D6022_RS11010	COG5518	Phage portal protein
D6022_RS11030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D6022_RS11040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D6022_RS11045	COG0028	Belongs to the TPP enzyme family
D6022_RS11050	COG0440	acetolactate synthase activity
D6022_RS11055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D6022_RS11060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6022_RS11065	COG0473	3-isopropylmalate dehydrogenase activity
D6022_RS11070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D6022_RS11075	COG0066	3-isopropylmalate dehydratase activity
D6022_RS11080	COG1477	protein flavinylation
D6022_RS11080	COG0457	Tetratricopeptide repeat
D6022_RS11085	COG0544	peptidyl-prolyl cis-trans isomerase activity
D6022_RS11090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D6022_RS11095	COG1067	ATP-dependent peptidase activity
D6022_RS11095	COG0470	DNA polymerase III
D6022_RS11100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D6022_RS11105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D6022_RS11115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D6022_RS11120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D6022_RS11125	COG0181	hydroxymethylbilane synthase activity
D6022_RS11130	COG1587	Uroporphyrinogen-III synthase
D6022_RS11135	COG0113	porphobilinogen synthase activity
D6022_RS11140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D6022_RS11145	COG1388	LysM domain
D6022_RS11150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D6022_RS11160	COG0525	valine-tRNA ligase activity
D6022_RS11165	COG0285	dihydrofolate synthase activity
D6022_RS11180	COG0424	maF-like protein
D6022_RS11190	COG1077	Cell shape determining protein MreB Mrl
D6022_RS11200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D6022_RS11205	COG0850	regulation of cytokinetic process
D6022_RS11210	COG2894	cell division
D6022_RS11215	COG0640	Transcriptional regulator
D6022_RS11220	COG3832	glyoxalase III activity
D6022_RS11225	COG0739	heme binding
D6022_RS11230	COG1994	Peptidase M50
D6022_RS11235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D6022_RS11240	COG2868	ribosomal protein
D6022_RS11245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D6022_RS11250	COG3290	protein histidine kinase activity
D6022_RS11255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D6022_RS11260	COG4492	Belongs to the UPF0735 family
D6022_RS11265	COG0077	Prephenate dehydratase
D6022_RS11270	COG1827	regulation of RNA biosynthetic process
D6022_RS11275	COG1104	cysteine desulfurase activity
D6022_RS11280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D6022_RS11285	COG0157	Belongs to the NadC ModD family
D6022_RS11290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D6022_RS11295	COG1388	LysM domain
D6022_RS11305	COG0217	transcriptional regulatory protein
D6022_RS11320	COG4195	phage-related replication protein
D6022_RS11325	COG2318	DinB family
D6022_RS11335	COG2112	serine threonine protein kinase
D6022_RS11345	COG0632	four-way junction helicase activity
D6022_RS11350	COG2255	four-way junction helicase activity
D6022_RS11360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D6022_RS11365	COG0343	queuine tRNA-ribosyltransferase activity
D6022_RS11370	COG1862	Preprotein translocase
D6022_RS11380	COG2323	membrane
D6022_RS11385	COG2244	polysaccharide biosynthetic process
D6022_RS11395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6022_RS11395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6022_RS11400	COG5416	Lipopolysaccharide assembly protein A domain
D6022_RS11405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D6022_RS11405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D6022_RS11410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D6022_RS11415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D6022_RS11420	COG1490	D-aminoacyl-tRNA deacylase activity
D6022_RS11425	COG4991	sh3 domain protein
D6022_RS11425	COG3103	Sh3 type 3 domain protein
D6022_RS11425	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS11430	COG0124	histidyl-tRNA synthetase
D6022_RS11435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D6022_RS11445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D6022_RS11450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D6022_RS11455	COG1959	2 iron, 2 sulfur cluster binding
D6022_RS11460	COG1104	cysteine desulfurase activity
D6022_RS11465	COG0482	sulfurtransferase activity
D6022_RS11470	COG0457	Tetratricopeptide repeat
D6022_RS11475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D6022_RS11480	COG3881	PFAM PRC-barrel domain
D6022_RS11495	COG0628	permease
D6022_RS11500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D6022_RS11505	COG4472	Bacterial protein of unknown function (DUF965)
D6022_RS11510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D6022_RS11515	COG3906	Belongs to the UPF0473 family
D6022_RS11520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D6022_RS11525	COG4122	O-methyltransferase activity
D6022_RS11530	COG0826	peptidase U32
D6022_RS11535	COG0826	peptidase U32
D6022_RS11540	COG0572	uridine kinase
D6022_RS11545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D6022_RS11565	COG2226	methyltransferase
D6022_RS11570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D6022_RS11575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D6022_RS11580	COG0626	cystathionine gamma-synthase activity
D6022_RS11605	COG2226	methyltransferase
D6022_RS11610	COG1404	Belongs to the peptidase S8 family
D6022_RS11615	COG1309	transcriptional regulator
D6022_RS11620	COG2124	cytochrome p450
D6022_RS11620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D6022_RS11630	COG2814	Major facilitator Superfamily
D6022_RS11640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS11650	COG1587	Uroporphyrinogen-III synthase
D6022_RS11655	COG3340	Belongs to the peptidase S51 family
D6022_RS11660	COG1733	regulation of RNA biosynthetic process
D6022_RS11665	COG2814	Major facilitator Superfamily
D6022_RS11670	COG0656	L-ascorbic acid biosynthetic process
D6022_RS11675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D6022_RS11700	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D6022_RS11700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D6022_RS11705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS11710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS11715	COG3715	PTS system
D6022_RS11720	COG3716	PTS system mannose fructose sorbose family IID component
D6022_RS11725	COG1621	beta-fructofuranosidase activity
D6022_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS11745	COG0730	response to heat
D6022_RS11750	COG2124	cytochrome p450
D6022_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS11785	COG4608	Belongs to the ABC transporter superfamily
D6022_RS11790	COG0444	Belongs to the ABC transporter superfamily
D6022_RS11795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6022_RS11800	COG0601	transmembrane transport
D6022_RS11805	COG0747	negative chemotaxis
D6022_RS11810	COG0492	ferredoxin-NADP+ reductase activity
D6022_RS11815	COG2197	response regulator
D6022_RS11820	COG4585	Histidine kinase
D6022_RS11825	COG3239	Fatty acid desaturase
D6022_RS11830	COG1733	regulation of RNA biosynthetic process
D6022_RS11835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D6022_RS11840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D6022_RS11845	COG0113	porphobilinogen synthase activity
D6022_RS11850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D6022_RS11895	COG1937	Protein conserved in bacteria
D6022_RS11900	COG2210	Belongs to the sulfur carrier protein TusA family
D6022_RS11905	COG0425	Belongs to the sulfur carrier protein TusA family
D6022_RS11905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6022_RS11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS11910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6022_RS11915	COG0425	Belongs to the sulfur carrier protein TusA family
D6022_RS11920	COG0730	response to heat
D6022_RS11925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS11930	COG4585	Histidine kinase
D6022_RS11935	COG2197	response regulator
D6022_RS12020	COG0577	efflux transmembrane transporter activity
D6022_RS12025	COG1136	(ABC) transporter
D6022_RS12070	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS12105	COG2427	Protein of unknown function (DUF1641)
D6022_RS12110	COG3383	formate dehydrogenase (NAD+) activity
D6022_RS12115	COG5609	conserved protein (DUF2294)
D6022_RS12120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS12125	COG2755	lipolytic protein G-D-S-L family
D6022_RS12140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D6022_RS12145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D6022_RS12150	COG1534	Rna-binding protein
D6022_RS12155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D6022_RS12160	COG1713	HD superfamily hydrolase involved in NAD metabolism
D6022_RS12165	COG0799	negative regulation of ribosome biogenesis
D6022_RS12170	COG2226	methyltransferase
D6022_RS12175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D6022_RS12180	COG1596	polysaccharide export
D6022_RS12180	COG1555	photosystem II stabilization
D6022_RS12185	COG2131	deaminase
D6022_RS12190	COG0658	competence protein
D6022_RS12190	COG2333	competence protein COMEC
D6022_RS12200	COG1466	dna polymerase III delta subunit
D6022_RS12205	COG0268	Binds directly to 16S ribosomal RNA
D6022_RS12210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D6022_RS12215	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS12225	COG0481	GTPase activity
D6022_RS12230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D6022_RS12235	COG1420	regulation of RNA biosynthetic process
D6022_RS12240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D6022_RS12245	COG0443	Heat shock 70 kDa protein
D6022_RS12250	COG0484	heat shock protein binding
D6022_RS12255	COG2264	protein methyltransferase activity
D6022_RS12260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D6022_RS12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6022_RS12270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D6022_RS12275	COG1283	sodium-dependent phosphate transmembrane transporter activity
D6022_RS12280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D6022_RS12285	COG1610	YqeY-like protein
D6022_RS12290	COG1030	water channel activity
D6022_RS12295	COG4864	UPF0365 protein
D6022_RS12310	COG0561	phosphatase activity
D6022_RS12315	COG1702	phosphate starvation-inducible protein PhoH
D6022_RS12320	COG1480	7TM receptor with intracellular HD hydrolase
D6022_RS12325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D6022_RS12330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D6022_RS12335	COG0295	cytidine deaminase activity
D6022_RS12340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D6022_RS12350	COG1381	Involved in DNA repair and RecF pathway recombination
D6022_RS12355	COG0752	glycyl-tRNA synthetase alpha subunit
D6022_RS12360	COG0751	glycine-tRNA ligase activity
D6022_RS12365	COG0517	IMP dehydrogenase activity
D6022_RS12370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D6022_RS12375	COG1671	Belongs to the UPF0178 family
D6022_RS12380	COG0358	DNA primase activity
D6022_RS12385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D6022_RS12390	COG2010	Cytochrome c
D6022_RS12405	COG5444	nuclease activity
D6022_RS12455	COG2384	SAM-dependent methyltransferase
D6022_RS12460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D6022_RS12465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D6022_RS12475	COG0513	Belongs to the DEAD box helicase family
D6022_RS12480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D6022_RS12490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS12495	COG1121	(ABC) transporter
D6022_RS12500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D6022_RS12505	COG0735	belongs to the Fur family
D6022_RS12510	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D6022_RS12515	COG4709	membrane
D6022_RS12520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D6022_RS12525	COG1388	LysM domain
D6022_RS12530	COG5521	maltodextrose utilization protein MalA
D6022_RS12535	COG2839	Protein conserved in bacteria
D6022_RS12540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D6022_RS12545	COG0477	Major facilitator Superfamily
D6022_RS12550	COG0768	penicillin binding
D6022_RS12555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D6022_RS12560	COG0573	inorganic phosphate transmembrane transporter activity
D6022_RS12565	COG0581	inorganic phosphate transmembrane transporter activity
D6022_RS12570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D6022_RS12575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D6022_RS12580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D6022_RS12595	COG0438	transferase activity, transferring glycosyl groups
D6022_RS12600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6022_RS12605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D6022_RS12610	COG0705	Rhomboid family
D6022_RS12610	COG0457	Tetratricopeptide repeat
D6022_RS12615	COG0697	spore germination
D6022_RS12620	COG4483	Protein conserved in bacteria
D6022_RS12625	COG1940	carbohydrate kinase activity
D6022_RS12630	COG1368	sulfuric ester hydrolase activity
D6022_RS12635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6022_RS12640	COG2866	Carboxypeptidase
D6022_RS12650	COG0011	TIGRFAM Protein of
D6022_RS12660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS12670	COG1393	Belongs to the ArsC family
D6022_RS12680	COG1366	Belongs to the anti-sigma-factor antagonist family
D6022_RS12685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D6022_RS12690	COG1459	type II secretion system
D6022_RS12695	COG4537	Required for transformation and DNA binding
D6022_RS12700	COG4970	Tfp pilus assembly protein FimT
D6022_RS12710	COG4940	Competence protein ComGF
D6022_RS12735	COG0681	Belongs to the peptidase S26 family
D6022_RS12760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6022_RS12765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D6022_RS12770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D6022_RS12775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D6022_RS12780	COG4175	Glycine betaine
D6022_RS12780	COG0517	IMP dehydrogenase activity
D6022_RS12785	COG4176	ABC-type proline glycine betaine transport system permease component
D6022_RS12790	COG2113	Glycine betaine
D6022_RS12795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6022_RS12800	COG0095	Lipoate-protein ligase
D6022_RS12805	COG1321	iron dependent repressor
D6022_RS12810	COG1752	Esterase of the alpha-beta hydrolase superfamily
D6022_RS12820	COG3872	metal-dependent enzyme
D6022_RS12830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D6022_RS12835	COG0006	proline dipeptidase activity
D6022_RS12840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D6022_RS12850	COG3854	ATPases associated with a variety of cellular activities
D6022_RS12890	COG0511	ligase activity, forming carbon-carbon bonds
D6022_RS12895	COG0439	Biotin carboxylase
D6022_RS12900	COG1302	Protein conserved in bacteria
D6022_RS12905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D6022_RS12910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D6022_RS12915	COG1570	exodeoxyribonuclease VII activity
D6022_RS12920	COG1722	exodeoxyribonuclease VII activity
D6022_RS12925	COG0142	geranyltranstransferase activity
D6022_RS12935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D6022_RS12940	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D6022_RS12945	COG1438	arginine binding
D6022_RS12950	COG0497	DNA recombination
D6022_RS12955	COG0750	zinc metalloprotease
D6022_RS12960	COG0745	RESPONSE REGULATOR receiver
D6022_RS12970	COG1045	serine acetyltransferase
D6022_RS12985	COG0860	N-Acetylmuramoyl-L-alanine amidase
D6022_RS12990	COG0584	glycerophosphoryl diester phosphodiesterase
D6022_RS13000	COG3829	transcription factor binding
D6022_RS13000	COG3290	protein histidine kinase activity
D6022_RS13005	COG0280	phosphate acetyltransferase
D6022_RS13015	COG3426	butyrate kinase activity
D6022_RS13020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6022_RS13025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D6022_RS13030	COG0022	dehydrogenase e1 component
D6022_RS13035	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6022_RS13040	COG1597	lipid kinase activity
D6022_RS13050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6022_RS13055	COG0765	amino acid transport
D6022_RS13060	COG1126	abc transporter atp-binding protein
D6022_RS13065	COG4129	membrane
D6022_RS13070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6022_RS13075	COG2195	Cleaves the N-terminal amino acid of tripeptides
D6022_RS13080	COG0706	membrane insertase activity
D6022_RS13090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D6022_RS13095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D6022_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS13105	COG1785	Belongs to the alkaline phosphatase family
D6022_RS13110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS13115	COG1447	Phosphotransferase system cellobiose-specific component IIA
D6022_RS13120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS13125	COG2723	6-phospho-beta-galactosidase activity
D6022_RS13130	COG2188	Transcriptional regulator
D6022_RS13135	COG2358	TRAP transporter, solute receptor (TAXI family
D6022_RS13150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D6022_RS13155	COG1234	tRNA 3'-trailer cleavage
D6022_RS13160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6022_RS13165	COG0596	Alpha beta hydrolase
D6022_RS13170	COG1902	pentaerythritol trinitrate reductase activity
D6022_RS13175	COG4187	Peptidase family M20/M25/M40
D6022_RS13180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D6022_RS13185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS13190	COG0300	oxidoreductase activity
D6022_RS13200	COG4195	phage-related replication protein
D6022_RS13220	COG1131	(ABC) transporter
D6022_RS13235	COG1072	(Pantothenic acid kinase))
D6022_RS13240	COG0346	lactoylglutathione lyase activity
D6022_RS13245	COG2211	Major facilitator Superfamily
D6022_RS13255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D6022_RS13270	COG0534	Mate efflux family protein
D6022_RS13280	COG0444	Belongs to the ABC transporter superfamily
D6022_RS13290	COG0601	transmembrane transport
D6022_RS13295	COG0747	negative chemotaxis
D6022_RS13305	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D6022_RS13315	COG2329	Antibiotic biosynthesis monooxygenase
D6022_RS13330	COG4918	Iron-sulphur cluster biosynthesis
D6022_RS13340	COG1073	alpha beta
D6022_RS13350	COG0667	Aldo Keto reductase
D6022_RS13360	COG1309	transcriptional regulator
D6022_RS13370	COG0494	nUDIX hydrolase
D6022_RS13375	COG1379	DNA repair
D6022_RS13380	COG2153	protein acetylation
D6022_RS13400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D6022_RS13405	COG1300	Membrane
D6022_RS13410	COG0735	belongs to the Fur family
D6022_RS13420	COG4974	Belongs to the 'phage' integrase family
D6022_RS13425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D6022_RS13430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D6022_RS13435	COG1686	Belongs to the peptidase S11 family
D6022_RS13470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6022_RS13485	COG0697	spore germination
D6022_RS13495	COG0019	diaminopimelate decarboxylase activity
D6022_RS13500	COG4195	phage-related replication protein
D6022_RS13505	COG4086	secreted protein
D6022_RS13510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D6022_RS13515	COG0457	Tetratricopeptide repeat
D6022_RS13540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D6022_RS13540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D6022_RS13545	COG0307	riboflavin synthase, alpha
D6022_RS13550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D6022_RS13550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D6022_RS13555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D6022_RS13560	COG0456	acetyltransferase
D6022_RS13565	COG1547	Domain of unknown function (DUF309)
D6022_RS13575	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D6022_RS13580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D6022_RS13590	COG1686	Belongs to the peptidase S11 family
D6022_RS13595	COG2715	membrane protein required for spore maturation
D6022_RS13605	COG1187	pseudouridine synthase activity
D6022_RS13610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS13615	COG1333	cytochrome c biogenesis protein
D6022_RS13620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D6022_RS13625	COG0745	RESPONSE REGULATOR receiver
D6022_RS13630	COG5002	protein histidine kinase activity
D6022_RS13635	COG0745	RESPONSE REGULATOR receiver
D6022_RS13640	COG5002	protein histidine kinase activity
D6022_RS13655	COG1316	TRANSCRIPTIONal
D6022_RS13660	COG1595	DNA-templated transcription, initiation
D6022_RS13670	COG0739	heme binding
D6022_RS13675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D6022_RS13680	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D6022_RS13685	COG1141	Ferredoxin
D6022_RS13690	COG4955	Helix-turn-helix domain
D6022_RS13695	COG0514	ATP-dependent DNA helicase (RecQ)
D6022_RS13700	COG1266	CAAX protease self-immunity
D6022_RS13705	COG1388	LysM domain
D6022_RS13720	COG4862	establishment of competence for transformation
D6022_RS13725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D6022_RS13730	COG0492	ferredoxin-NADP+ reductase activity
D6022_RS13740	COG2339	peptidase activity
D6022_RS13745	COG3409	Peptidoglycan-binding domain 1 protein
D6022_RS13745	COG3773	Cell wall hydrolase
D6022_RS13750	COG2959	enzyme of heme biosynthesis
D6022_RS13755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D6022_RS13760	COG0539	negative regulation of cytoplasmic translation
D6022_RS13765	COG1304	FMN binding
D6022_RS13790	COG1160	GTP binding
D6022_RS13795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D6022_RS13815	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D6022_RS13820	COG0776	regulation of translation
D6022_RS13835	COG0142	geranyltranstransferase activity
D6022_RS13840	COG2226	methyltransferase
D6022_RS13845	COG0142	geranyltranstransferase activity
D6022_RS13850	COG0105	UTP biosynthetic process
D6022_RS13855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D6022_RS13860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D6022_RS13865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D6022_RS13870	COG4401	Chorismate mutase type I
D6022_RS13875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D6022_RS13880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6022_RS13885	COG0134	indole-3-glycerol-phosphate synthase activity
D6022_RS13890	COG0135	phosphoribosylanthranilate isomerase activity
D6022_RS13895	COG0133	tryptophan synthase activity
D6022_RS13900	COG0159	tryptophan synthase activity
D6022_RS13905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D6022_RS13910	COG0287	Prephenate dehydrogenase
D6022_RS13915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D6022_RS13920	COG0457	Tetratricopeptide repeat
D6022_RS13925	COG5582	Belongs to the UPF0302 family
D6022_RS13935	COG0723	plastoquinol--plastocyanin reductase activity
D6022_RS13940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D6022_RS13945	COG2010	Cytochrome c
D6022_RS13945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D6022_RS13950	COG4347	Protein of unknown function (DUF1405)
D6022_RS13960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS13965	COG1694	Mazg nucleotide pyrophosphohydrolase
D6022_RS13970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D6022_RS13975	COG1803	Methylglyoxal synthase
D6022_RS13980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6022_RS13985	COG0438	transferase activity, transferring glycosyl groups
D6022_RS13990	COG0617	tRNA 3'-terminal CCA addition
D6022_RS14005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D6022_RS14010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D6022_RS14015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D6022_RS14020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D6022_RS14020	COG1199	ATP-dependent helicase activity
D6022_RS14030	COG5353	protein conserved in bacteria
D6022_RS14035	COG0436	Aminotransferase
D6022_RS14040	COG0017	Asparaginyl-tRNA synthetase
D6022_RS14045	COG3935	DnaD domain protein
D6022_RS14050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D6022_RS14060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6022_RS14060	COG4499	WXG100 protein secretion system (Wss), protein YukC
D6022_RS14065	COG3331	DNA recombination
D6022_RS14105	COG0071	Belongs to the small heat shock protein (HSP20) family
D6022_RS14110	COG2190	(PTS) system
D6022_RS14115	COG1205	dead DEAH box helicase
D6022_RS14115	COG1111	helicase
D6022_RS14120	COG3359	exonuclease
D6022_RS14130	COG4474	Belongs to the UPF0398 family
D6022_RS14135	COG3599	regulation of cell shape
D6022_RS14145	COG0116	Belongs to the methyltransferase superfamily
D6022_RS14155	COG1199	ATP-dependent helicase activity
D6022_RS14160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D6022_RS14165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D6022_RS14170	COG2233	PERMEase
D6022_RS14175	COG0456	acetyltransferase
D6022_RS14180	COG3424	synthase
D6022_RS14185	COG1755	Isoprenylcysteine carboxyl methyltransferase
D6022_RS14195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D6022_RS14205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6022_RS14215	COG0328	RNA-DNA hybrid ribonuclease activity
D6022_RS14220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D6022_RS14225	COG0328	RNA-DNA hybrid ribonuclease activity
D6022_RS14245	COG1278	Cold shock
D6022_RS14255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6022_RS14260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D6022_RS14265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D6022_RS14270	COG0386	Belongs to the glutathione peroxidase family
D6022_RS14275	COG1418	mRNA catabolic process
D6022_RS14280	COG1413	lyase activity
D6022_RS14295	COG0129	dihydroxy-acid dehydratase activity
D6022_RS14305	COG2136	Putative SAM-dependent methyltransferase
D6022_RS14305	COG2521	methyltransferase
D6022_RS14315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D6022_RS14325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D6022_RS14330	COG0204	Acyl-transferase
D6022_RS14335	COG1272	protein, Hemolysin III
D6022_RS14340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D6022_RS14345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D6022_RS14360	COG1999	signal sequence binding
D6022_RS14365	COG2755	lipolytic protein G-D-S-L family
D6022_RS14370	COG4698	Protein conserved in bacteria
D6022_RS14385	COG0534	Mate efflux family protein
D6022_RS14390	COG3706	GGDEF domain
D6022_RS14400	COG1846	Transcriptional regulator
D6022_RS14405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6022_RS14410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6022_RS14415	COG0456	acetyltransferase
D6022_RS14430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6022_RS14435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D6022_RS14440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D6022_RS14445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6022_RS14450	COG0456	acetyltransferase
D6022_RS14455	COG1509	lysine 2,3-aminomutase activity
D6022_RS14460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D6022_RS14470	COG4282	regulation of fungal-type cell wall biogenesis
D6022_RS14505	COG2814	Major facilitator Superfamily
D6022_RS14510	COG0457	Tetratricopeptide repeat
D6022_RS14535	COG5632	N-Acetylmuramoyl-L-alanine amidase
D6022_RS14550	COG2433	Pfam Transposase IS66
D6022_RS14560	COG0739	heme binding
D6022_RS14560	COG0741	lytic transglycosylase activity
D6022_RS14560	COG1196	nuclear chromosome segregation
D6022_RS14565	COG0739	heme binding
D6022_RS14565	COG1196	nuclear chromosome segregation
D6022_RS14565	COG0741	lytic transglycosylase activity
D6022_RS14570	COG0739	heme binding
D6022_RS14570	COG0741	lytic transglycosylase activity
D6022_RS14570	COG1196	nuclear chromosome segregation
D6022_RS14640	COG0582	viral genome integration into host DNA
D6022_RS14760	COG0776	regulation of translation
D6022_RS14790	COG1404	Belongs to the peptidase S8 family
D6022_RS14865	COG3655	Transcriptional regulator
D6022_RS14955	COG1404	Belongs to the peptidase S8 family
D6022_RS14985	COG0582	viral genome integration into host DNA
D6022_RS15015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D6022_RS15025	COG4474	Belongs to the UPF0398 family
D6022_RS15080	COG1793	dna ligase
D6022_RS15150	COG2887	Belongs to the helicase family. UvrD subfamily
D6022_RS15160	COG0305	Participates in initiation and elongation during chromosome replication
D6022_RS15165	COG0358	DNA primase activity
D6022_RS15170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D6022_RS15175	COG0587	DNA-directed DNA polymerase activity
D6022_RS15185	COG0587	DNA-directed DNA polymerase activity
D6022_RS15190	COG3584	3D domain protein
D6022_RS15260	COG1780	Probably involved in ribonucleotide reductase function
D6022_RS15265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6022_RS15270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6022_RS15270	COG1372	Participates in initiation and elongation during chromosome replication
D6022_RS15285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6022_RS15295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS15305	COG0756	dUTP diphosphatase activity
D6022_RS15320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D6022_RS15350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D6022_RS15375	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D6022_RS15385	COG3331	DNA recombination
D6022_RS15400	COG4479	Belongs to the UPF0346 family
D6022_RS15415	COG0671	phosphoesterase, PA-phosphatase related
D6022_RS15435	COG0701	Predicted permease
D6022_RS15440	COG0813	purine-nucleoside phosphorylase activity
D6022_RS15445	COG1876	peptidase activity
D6022_RS15455	COG2226	methyltransferase
D6022_RS15460	COG0793	Belongs to the peptidase S41A family
D6022_RS15460	COG3409	Peptidoglycan-binding domain 1 protein
D6022_RS15470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS15480	COG0400	carboxylic ester hydrolase activity
D6022_RS15485	COG0778	Nitroreductase
D6022_RS15490	COG1733	regulation of RNA biosynthetic process
D6022_RS15495	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS15505	COG4305	rare lipoprotein A
D6022_RS15515	COG2962	Rard protein
D6022_RS15525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6022_RS15530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6022_RS15535	COG0534	Mate efflux family protein
D6022_RS15550	COG2032	superoxide dismutase activity
D6022_RS15555	COG0714	Associated with various cellular activities
D6022_RS15560	COG4548	von Willebrand factor, type A
D6022_RS15565	COG0567	Dehydrogenase, E1 component
D6022_RS15570	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6022_RS15575	COG0385	Bile acid
D6022_RS15580	COG0733	neurotransmitter:sodium symporter activity
D6022_RS15590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D6022_RS15595	COG1657	PFAM Prenyltransferase squalene oxidase
D6022_RS15610	COG2814	Major facilitator Superfamily
D6022_RS15615	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS15630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D6022_RS15635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D6022_RS15640	COG2318	DinB family
D6022_RS15655	COG1309	transcriptional regulator
D6022_RS15660	COG3848	Pyruvate phosphate dikinase
D6022_RS15660	COG0574	Belongs to the PEP-utilizing enzyme family
D6022_RS15670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6022_RS15675	COG1280	lysine exporter protein (LysE YggA)
D6022_RS15690	COG2267	carboxylic ester hydrolase activity
D6022_RS15705	COG0402	S-adenosylhomocysteine deaminase activity
D6022_RS15750	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D6022_RS15795	COG2315	Protein conserved in bacteria
D6022_RS15815	COG0514	ATP-dependent DNA helicase (RecQ)
D6022_RS15820	COG3584	3D domain protein
D6022_RS15820	COG1388	LysM domain
D6022_RS15825	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS15840	COG2322	membrane
D6022_RS15860	COG1086	Polysaccharide biosynthesis protein
D6022_RS15865	COG0741	lytic transglycosylase activity
D6022_RS15870	COG0531	amino acid
D6022_RS15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS15885	COG0640	Transcriptional regulator
D6022_RS15895	COG2378	regulation of single-species biofilm formation
D6022_RS15905	COG3708	Transcriptional regulator
D6022_RS15910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS15915	COG1309	transcriptional regulator
D6022_RS15945	COG1846	Transcriptional regulator
D6022_RS15950	COG1309	transcriptional regulator
D6022_RS15960	COG1404	Belongs to the peptidase S8 family
D6022_RS15965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6022_RS15970	COG0840	transmembrane signaling receptor activity
D6022_RS15975	COG0488	(ABC) transporter
D6022_RS15980	COG0697	spore germination
D6022_RS15990	COG0531	amino acid
D6022_RS16000	COG0531	amino acid
D6022_RS16010	COG1846	Transcriptional regulator
D6022_RS16015	COG0243	molybdopterin cofactor binding
D6022_RS16020	COG0477	Major facilitator Superfamily
D6022_RS16030	COG0574	Belongs to the PEP-utilizing enzyme family
D6022_RS16030	COG3848	Pyruvate phosphate dikinase
D6022_RS16035	COG0300	oxidoreductase activity
D6022_RS16045	COG1132	(ABC) transporter
D6022_RS16055	COG1846	Transcriptional regulator
D6022_RS16075	COG0583	DNA-binding transcription factor activity
D6022_RS16080	COG0069	glutamate synthase activity
D6022_RS16080	COG0067	glutamate synthase
D6022_RS16080	COG0070	glutamate synthase
D6022_RS16085	COG0493	'glutamate synthase
D6022_RS16100	COG0463	Glycosyl transferase, family 2
D6022_RS16105	COG2814	Major facilitator Superfamily
D6022_RS16110	COG4948	Mandelate Racemase Muconate Lactonizing
D6022_RS16115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS16120	COG1809	phosphosulfolactate synthase activity
D6022_RS16125	COG0175	sulfate reduction
D6022_RS16130	COG0306	phosphate transporter
D6022_RS16140	COG2323	membrane
D6022_RS16150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D6022_RS16155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D6022_RS16160	COG1733	regulation of RNA biosynthetic process
D6022_RS16165	COG2249	NAD(P)H dehydrogenase (quinone) activity
D6022_RS16170	COG1960	acyl-CoA dehydrogenase activity
D6022_RS16175	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS16180	COG0439	Biotin carboxylase
D6022_RS16185	COG0511	ligase activity, forming carbon-carbon bonds
D6022_RS16190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6022_RS16195	COG1024	Enoyl-CoA hydratase
D6022_RS16200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6022_RS16205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6022_RS16215	COG0166	Belongs to the GPI family
D6022_RS16230	COG1252	NADH dehydrogenase
D6022_RS16235	COG2027	D-alanyl-D-alanine carboxypeptidase
D6022_RS16245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D6022_RS16250	COG2404	hydrolase activity, acting on ester bonds
D6022_RS16255	COG1649	PFAM Uncharacterised BCR, COG1649
D6022_RS16270	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D6022_RS16280	COG0640	Transcriptional regulator
D6022_RS16285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D6022_RS16290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6022_RS16295	COG1609	Transcriptional regulator
D6022_RS16305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D6022_RS16320	COG1312	Catalyzes the dehydration of D-mannonate
D6022_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS16330	COG1725	Transcriptional regulator
D6022_RS16345	COG3711	transcriptional antiterminator
D6022_RS16345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS16370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS16370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS16370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS16375	COG1482	cell wall glycoprotein biosynthetic process
D6022_RS16380	COG1960	acyl-CoA dehydrogenase activity
D6022_RS16385	COG2084	Dehydrogenase
D6022_RS16390	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS16395	COG1024	Enoyl-CoA hydratase
D6022_RS16420	COG0789	Transcriptional regulator
D6022_RS16430	COG1114	Component of the transport system for branched-chain amino acids
D6022_RS16435	COG3420	alginic acid biosynthetic process
D6022_RS16460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS16470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D6022_RS16480	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D6022_RS16500	COG2223	nitrite transmembrane transporter activity
D6022_RS16505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D6022_RS16515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D6022_RS16520	COG0535	radical SAM domain protein
D6022_RS16535	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D6022_RS16540	COG1140	nitrate reductase beta subunit
D6022_RS16545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D6022_RS16550	COG2181	nitrate reductase activity
D6022_RS16560	COG1115	amino acid carrier protein
D6022_RS16580	COG2160	L-arabinose isomerase activity
D6022_RS16595	COG1609	Transcriptional regulator
D6022_RS16600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D6022_RS16605	COG0187	DNA topoisomerase II activity
D6022_RS16610	COG1832	CoA-binding protein
D6022_RS16615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D6022_RS16620	COG4841	protein insertion into membrane
D6022_RS16645	COG0824	Thioesterase
D6022_RS16665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS16670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D6022_RS16685	COG0071	Belongs to the small heat shock protein (HSP20) family
D6022_RS16695	COG4846	Membrane protein involved in cytochrome C biogenesis
D6022_RS16700	COG2201	protein-glutamate methylesterase activity
D6022_RS16705	COG0785	Cytochrome C biogenesis protein
D6022_RS16715	COG3763	UPF0154 protein
D6022_RS16725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D6022_RS16730	COG4224	UPF0291 protein
D6022_RS16735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D6022_RS16740	COG1388	LysM domain
D6022_RS16745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D6022_RS16750	COG3209	COG3209 Rhs family protein
D6022_RS16770	COG0655	NAD(P)H dehydrogenase (quinone) activity
D6022_RS16775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D6022_RS16780	COG0346	lactoylglutathione lyase activity
D6022_RS16785	COG0778	Nitroreductase
D6022_RS16790	COG1846	Transcriptional regulator
D6022_RS16815	COG3546	catalase activity
D6022_RS16835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS16840	COG2076	Multidrug Resistance protein
D6022_RS16845	COG2076	Multidrug Resistance protein
D6022_RS16890	COG1073	alpha beta
D6022_RS16930	COG0174	glutamine synthetase
D6022_RS16935	COG0789	Transcriptional regulator
D6022_RS16940	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D6022_RS16945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D6022_RS16950	COG0464	growth
D6022_RS17005	COG1309	transcriptional regulator
D6022_RS17040	COG0697	spore germination
D6022_RS17045	COG1802	Transcriptional regulator
D6022_RS17050	COG0735	belongs to the Fur family
D6022_RS17065	COG4112	unkown
D6022_RS17070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6022_RS17075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6022_RS17080	COG1780	Probably involved in ribonucleotide reductase function
D6022_RS17095	COG1923	regulation of RNA biosynthetic process
D6022_RS17100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D6022_RS17115	COG2076	Multidrug Resistance protein
D6022_RS17120	COG2076	Multidrug Resistance protein
D6022_RS17125	COG1764	response to oxidative stress
D6022_RS17135	COG0702	epimerase
D6022_RS17140	COG3631	Ketosteroid isomerase-related protein
D6022_RS17145	COG1309	transcriptional regulator
D6022_RS17150	COG3858	chitin binding
D6022_RS17150	COG1388	LysM domain
D6022_RS17160	COG5577	PFAM Coat F domain
D6022_RS17165	COG0531	amino acid
D6022_RS17170	COG1819	glycosyl
D6022_RS17175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6022_RS17180	COG0398	Pfam SNARE associated Golgi protein
D6022_RS17185	COG0393	Putative heavy-metal-binding
D6022_RS17205	COG3263	regulation of cellular component size
D6022_RS17210	COG3619	membrane
D6022_RS17215	COG1231	oxidoreductase activity
D6022_RS17230	COG1247	-acetyltransferase
D6022_RS17240	COG0523	cobalamin synthesis protein
D6022_RS17260	COG5444	nuclease activity
D6022_RS17265	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D6022_RS17270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D6022_RS17275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D6022_RS17285	COG4550	Control of competence regulator ComK, YlbF/YmcA
D6022_RS17290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6022_RS17295	COG0156	8-amino-7-oxononanoate synthase activity
D6022_RS17300	COG1063	alcohol dehydrogenase
D6022_RS17310	COG2359	stage V sporulation protein S
D6022_RS17315	COG1692	metallophosphoesterase
D6022_RS17320	COG1418	mRNA catabolic process
D6022_RS17330	COG1058	Belongs to the CinA family
D6022_RS17330	COG1546	Belongs to the CinA family
D6022_RS17335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D6022_RS17340	COG1426	Protein conserved in bacteria
D6022_RS17355	COG0300	oxidoreductase activity
D6022_RS17360	COG0612	Peptidase, M16
D6022_RS17365	COG0612	Peptidase, M16
D6022_RS17370	COG2814	Major facilitator Superfamily
D6022_RS17375	COG2188	Transcriptional regulator
D6022_RS17380	COG4980	gas vesicle protein
D6022_RS17380	COG1674	ftsk spoiiie
D6022_RS17390	COG0740	serine-type endopeptidase activity
D6022_RS17395	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D6022_RS17405	COG0527	aspartate kinase activity
D6022_RS17410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D6022_RS17415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D6022_RS17420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D6022_RS17425	COG1873	PFAM PRC-barrel domain
D6022_RS17430	COG0612	Peptidase, M16
D6022_RS17435	COG0726	polysaccharide deacetylase
D6022_RS17440	COG1185	polyribonucleotide nucleotidyltransferase activity
D6022_RS17445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D6022_RS17450	COG0196	riboflavin kinase activity
D6022_RS17455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D6022_RS17460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D6022_RS17465	COG1550	Protein conserved in bacteria
D6022_RS17470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D6022_RS17475	COG1358	cellular component organization or biogenesis
D6022_RS17480	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D6022_RS17485	COG0195	Participates in both transcription termination and antitermination
D6022_RS17490	COG0779	Required for maturation of 30S ribosomal subunits
D6022_RS17520	COG2176	DNA-directed DNA polymerase activity
D6022_RS17525	COG0442	prolyl-tRNA aminoacylation
D6022_RS17530	COG0750	zinc metalloprotease
D6022_RS17535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D6022_RS17540	COG4589	Belongs to the CDS family
D6022_RS17545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6022_RS17550	COG0233	cytoplasmic translational termination
D6022_RS17555	COG0528	UMP kinase activity
D6022_RS17560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D6022_RS17565	COG0052	Belongs to the universal ribosomal protein uS2 family
D6022_RS17575	COG1191	sigma factor activity
D6022_RS17580	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D6022_RS17585	COG1776	CheC inhibitor of MCP methylation
D6022_RS17590	COG0835	chemotaxis
D6022_RS17595	COG0643	Histidine kinase
D6022_RS17595	COG2198	Histidine kinase
D6022_RS17600	COG2201	protein-glutamate methylesterase activity
D6022_RS17605	COG0455	bacterial-type flagellum organization
D6022_RS17610	COG1419	protein localization to endoplasmic reticulum
D6022_RS17615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D6022_RS17620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D6022_RS17625	COG1684	flagellar biosynthetic protein fliR
D6022_RS17630	COG1987	bacterial-type flagellum assembly
D6022_RS17635	COG1338	Plays a role in the flagellum-specific transport system
D6022_RS17640	COG3190	flagellar
D6022_RS17645	COG2201	protein-glutamate methylesterase activity
D6022_RS17650	COG1776	CheC inhibitor of MCP methylation
D6022_RS17650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D6022_RS17655	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D6022_RS17660	COG1580	Controls the rotational direction of flagella during chemotaxis
D6022_RS17665	COG1582	Flagellar protein (FlbD)
D6022_RS17670	COG4786	Flagellar basal body rod
D6022_RS17675	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D6022_RS17680	COG3144	bacterial-type flagellum assembly
D6022_RS17690	COG2882	bacterial-type flagellum organization
D6022_RS17695	COG1157	protein secretion by the type III secretion system
D6022_RS17700	COG1317	bacterial-type flagellum organization
D6022_RS17705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D6022_RS17710	COG1766	The M ring may be actively involved in energy transduction
D6022_RS17715	COG1677	Flagellar hook-basal body complex protein FliE
D6022_RS17720	COG1558	bacterial-type flagellum-dependent cell motility
D6022_RS17725	COG1815	bacterial-type flagellum-dependent cell motility
D6022_RS17730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D6022_RS17735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D6022_RS17740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D6022_RS17745	COG4974	Belongs to the 'phage' integrase family
D6022_RS17750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D6022_RS17755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D6022_RS17760	COG0758	DNA mediated transformation
D6022_RS17765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D6022_RS17770	COG0045	succinate-CoA ligase (ADP-forming) activity
D6022_RS17785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D6022_RS17790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D6022_RS17795	COG0335	large ribosomal subunit rRNA binding
D6022_RS17800	COG0336	Belongs to the RNA methyltransferase TrmD family
D6022_RS17805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D6022_RS17815	COG1837	Belongs to the UPF0109 family
D6022_RS17820	COG0228	four-way junction DNA binding
D6022_RS17825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D6022_RS17830	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D6022_RS17835	COG0552	protein localization to endoplasmic reticulum
D6022_RS17840	COG1196	nuclear chromosome segregation
D6022_RS17845	COG0571	ribonuclease III activity
D6022_RS17850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D6022_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS17860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D6022_RS17865	COG0416	fatty acid biosynthetic process
D6022_RS17870	COG1349	DNA-binding transcription factor activity
D6022_RS17875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D6022_RS17880	COG1760	l-serine dehydratase
D6022_RS17885	COG1760	l-serine dehydratase
D6022_RS17890	COG1461	Dihydroxyacetone kinase
D6022_RS17895	COG1302	Protein conserved in bacteria
D6022_RS17900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D6022_RS17910	COG1564	THIamine pyrophosphokinase
D6022_RS17915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D6022_RS17920	COG1162	GTPase activity
D6022_RS17925	COG0515	serine threonine protein kinase
D6022_RS17925	COG2815	serine threonine protein kinase
D6022_RS17930	COG0631	protein serine/threonine phosphatase activity
D6022_RS17935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D6022_RS17940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D6022_RS17940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D6022_RS17945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D6022_RS17950	COG0242	peptide deformylase activity
D6022_RS17955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D6022_RS17960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D6022_RS17965	COG1758	RNA polymerase activity
D6022_RS17970	COG0194	GDP metabolic process
D6022_RS17975	COG2052	Domain of unknown function (DUF370)
D6022_RS17980	COG1561	YicC-like family, N-terminal region
D6022_RS17985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D6022_RS17995	COG1648	precorrin-2 dehydrogenase activity
D6022_RS18000	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D6022_RS18005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6022_RS18010	COG0529	Catalyzes the synthesis of activated sulfate
D6022_RS18015	COG2046	Belongs to the sulfate adenylyltransferase family
D6022_RS18020	COG0306	phosphate transporter
D6022_RS18025	COG0175	sulfate reduction
D6022_RS18035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D6022_RS18040	COG0284	orotidine-5'-phosphate decarboxylase activity
D6022_RS18045	COG0167	dihydroorotate dehydrogenase activity
D6022_RS18050	COG0543	2 iron, 2 sulfur cluster binding
D6022_RS18055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D6022_RS18060	COG0505	Belongs to the CarA family
D6022_RS18065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6022_RS18070	COG0540	Belongs to the ATCase OTCase family
D6022_RS18075	COG2233	PERMEase
D6022_RS18080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D6022_RS18085	COG0564	pseudouridine synthase activity
D6022_RS18090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D6022_RS18095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D6022_RS18100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D6022_RS18105	COG3599	regulation of cell shape
D6022_RS18110	COG2302	S4 RNA-binding domain
D6022_RS18115	COG0762	integral membrane protein
D6022_RS18120	COG1799	cell septum assembly
D6022_RS18125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D6022_RS18130	COG1496	oxidoreductase activity
D6022_RS18135	COG1873	PFAM PRC-barrel domain
D6022_RS18140	COG0500	methyltransferase
D6022_RS18145	COG1119	ATPase activity
D6022_RS18150	COG1191	sigma factor activity
D6022_RS18155	COG1191	sigma factor activity
D6022_RS18170	COG1404	Belongs to the peptidase S8 family
D6022_RS18170	COG4412	M6 family metalloprotease domain protein
D6022_RS18175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D6022_RS18180	COG0849	cell division
D6022_RS18185	COG3856	small basic protein
D6022_RS18190	COG3879	Bacterial protein of unknown function (DUF881)
D6022_RS18195	COG3879	Bacterial protein of unknown function (DUF881)
D6022_RS18200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D6022_RS18205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D6022_RS18210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6022_RS18215	COG0772	Belongs to the SEDS family
D6022_RS18220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D6022_RS18225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6022_RS18230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D6022_RS18235	COG0768	penicillin binding
D6022_RS18240	COG0768	penicillin binding
D6022_RS18245	COG4839	cell division protein FtsL
D6022_RS18250	COG0275	rRNA processing
D6022_RS18255	COG2001	Belongs to the MraZ family
D6022_RS18260	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D6022_RS18265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D6022_RS18270	COG0454	-acetyltransferase
D6022_RS18280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D6022_RS18285	COG1399	metal-binding, possibly nucleic acid-binding protein
D6022_RS18290	COG1323	Belongs to the UPF0348 family
D6022_RS18295	COG3480	Lon protease (S16) C-terminal proteolytic domain
D6022_RS18300	COG3314	Sporulation integral membrane protein YlbJ
D6022_RS18305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D6022_RS18310	COG0742	ribosomal rna small subunit methyltransferase
D6022_RS18315	COG4471	UPF0298 protein
D6022_RS18320	COG3679	Belongs to the UPF0342 family
D6022_RS18335	COG2340	Cysteine-rich secretory protein family
D6022_RS18340	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D6022_RS18350	COG3336	cytochrome c oxidase
D6022_RS18355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D6022_RS18360	COG1845	cytochrome c oxidase, subunit III
D6022_RS18365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D6022_RS18370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D6022_RS18370	COG2010	Cytochrome c
D6022_RS18375	COG0109	protoheme IX farnesyltransferase activity
D6022_RS18380	COG1612	heme a metabolic process
D6022_RS18385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D6022_RS18390	COG0772	Belongs to the SEDS family
D6022_RS18395	COG4838	Belongs to the UPF0358 family
D6022_RS18400	COG2066	Belongs to the glutaminase family
D6022_RS18405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D6022_RS18410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D6022_RS18420	COG4896	Protein conserved in bacteria
D6022_RS18425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D6022_RS18430	COG1846	Transcriptional regulator
D6022_RS18440	COG1217	gtp-binding protein TYPA
D6022_RS18455	COG1595	DNA-templated transcription, initiation
D6022_RS18475	COG0483	inositol monophosphate 1-phosphatase activity
D6022_RS18485	COG4493	Belongs to the UPF0637 family
D6022_RS18490	COG4476	Belongs to the UPF0223 family
D6022_RS18500	COG1982	Orn Lys Arg decarboxylase major
D6022_RS18515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6022_RS18520	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6022_RS18525	COG0022	dehydrogenase e1 component
D6022_RS18530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D6022_RS18535	COG0497	DNA recombination
D6022_RS18545	COG0242	peptide deformylase activity
D6022_RS18560	COG5503	Protein of unknown function (DUF1447)
D6022_RS18565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D6022_RS18570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D6022_RS18575	COG0569	domain protein
D6022_RS18580	COG3852	Histidine kinase
D6022_RS18585	COG2002	toxin-antitoxin pair type II binding
D6022_RS18590	COG1077	Cell shape determining protein MreB Mrl
D6022_RS18600	COG2309	aminopeptidase activity
D6022_RS18610	COG0488	(ABC) transporter
D6022_RS18630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS18630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D6022_RS18630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS18635	COG1105	Belongs to the carbohydrate kinase PfkB family
D6022_RS18640	COG1349	DNA-binding transcription factor activity
D6022_RS18645	COG0577	efflux transmembrane transporter activity
D6022_RS18650	COG1136	(ABC) transporter
D6022_RS18655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D6022_RS18665	COG1132	(ABC) transporter
D6022_RS18670	COG1132	(ABC) transporter
D6022_RS18680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D6022_RS18685	COG0314	molybdopterin synthase activity
D6022_RS18690	COG1763	Mo-molybdopterin cofactor biosynthetic process
D6022_RS18695	COG0303	'Molybdopterin
D6022_RS18700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D6022_RS18705	COG0746	molybdenum cofactor guanylyltransferase activity
D6022_RS18720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS18725	COG0450	alkyl hydroperoxide reductase
D6022_RS18735	COG1473	amidohydrolase
D6022_RS18740	COG2171	N-acyltransferase activity
D6022_RS18745	COG0716	FMN binding
D6022_RS18755	COG0716	FMN binding
D6022_RS18760	COG0583	DNA-binding transcription factor activity
D6022_RS18765	COG0517	IMP dehydrogenase activity
D6022_RS18775	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D6022_RS18780	COG4703	Protein of unknown function (DUF1797)
D6022_RS18790	COG2200	EAL domain
D6022_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS18800	COG1408	metallophosphoesterase
D6022_RS18810	COG1376	ErfK ybiS ycfS ynhG family protein
D6022_RS18815	COG2814	Major facilitator Superfamily
D6022_RS18825	COG0835	chemotaxis
D6022_RS18825	COG0784	Response regulator, receiver
D6022_RS18835	COG1714	RDD family
D6022_RS18840	COG0436	Aminotransferase
D6022_RS18845	COG4191	Histidine kinase
D6022_RS18850	COG0768	penicillin binding
D6022_RS18855	COG2340	Cysteine-rich secretory protein family
D6022_RS18860	COG2084	Dehydrogenase
D6022_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS18870	COG0840	transmembrane signaling receptor activity
D6022_RS18875	COG0456	acetyltransferase
D6022_RS18880	COG1533	DNA photolyase activity
D6022_RS18890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6022_RS18895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6022_RS18900	COG1263	PTS System
D6022_RS18900	COG2190	(PTS) system
D6022_RS18900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS18905	COG3711	transcriptional antiterminator
D6022_RS18910	COG1609	Transcriptional regulator
D6022_RS18920	COG0006	proline dipeptidase activity
D6022_RS18925	COG2217	Heavy metal translocating P-type atpase
D6022_RS18930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6022_RS18935	COG2244	polysaccharide biosynthetic process
D6022_RS18940	COG3773	Cell wall hydrolase
D6022_RS18950	COG4873	Protein conserved in bacteria
D6022_RS18980	COG3655	Transcriptional regulator
D6022_RS18985	COG3739	integral membrane protein
D6022_RS18995	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D6022_RS19000	COG0602	queuosine metabolic process
D6022_RS19005	COG0720	synthase
D6022_RS19010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D6022_RS19015	COG3949	Membrane
D6022_RS19020	COG0542	response to heat
D6022_RS19025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D6022_RS19030	COG1360	Flagellar Motor Protein
D6022_RS19035	COG1846	Transcriptional regulator
D6022_RS19040	COG3852	Histidine kinase
D6022_RS19050	COG3339	Conserved Protein
D6022_RS19055	COG0346	lactoylglutathione lyase activity
D6022_RS19060	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D6022_RS19065	COG0235	Class ii aldolase
D6022_RS19065	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D6022_RS19070	COG1850	ribulose-bisphosphate carboxylase activity
D6022_RS19075	COG0436	Aminotransferase
D6022_RS19080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D6022_RS19085	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D6022_RS19090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D6022_RS19095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D6022_RS19100	COG5002	protein histidine kinase activity
D6022_RS19105	COG3594	Acyltransferase
D6022_RS19120	COG0768	penicillin binding
D6022_RS19125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D6022_RS19130	COG0501	Belongs to the peptidase M48B family
D6022_RS19150	COG1191	sigma factor activity
D6022_RS19155	COG0861	Integral membrane protein TerC family
D6022_RS19160	COG0586	Pfam SNARE associated Golgi protein
D6022_RS19165	COG3300	MHYT domain
D6022_RS19165	COG5001	Diguanylate cyclase
D6022_RS19170	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D6022_RS19175	COG1793	dna ligase
D6022_RS19175	COG3285	dna ligase
D6022_RS19180	COG1846	Transcriptional regulator
D6022_RS19195	COG0789	Transcriptional regulator
D6022_RS19205	COG2239	Acts as a magnesium transporter
D6022_RS19215	COG1404	Belongs to the peptidase S8 family
D6022_RS19220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D6022_RS19235	COG0406	alpha-ribazole phosphatase activity
D6022_RS19240	COG0590	tRNA wobble adenosine to inosine editing
D6022_RS19250	COG1764	response to oxidative stress
D6022_RS19255	COG1846	Transcriptional regulator
D6022_RS19265	COG1764	response to oxidative stress
D6022_RS19270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D6022_RS19275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D6022_RS19280	COG0788	formyltetrahydrofolate deformylase activity
D6022_RS19285	COG2076	Multidrug Resistance protein
D6022_RS19290	COG2076	Multidrug Resistance protein
D6022_RS19295	COG2318	DinB family
D6022_RS19325	COG1607	acyl-coa hydrolase
D6022_RS19330	COG1834	amidinotransferase
D6022_RS19335	COG4608	Belongs to the ABC transporter superfamily
D6022_RS19340	COG0791	NLP P60 protein
D6022_RS19350	COG1619	proteins homologs of microcin C7 resistance protein MccF
D6022_RS19355	COG4166	transmembrane transport
D6022_RS19360	COG0444	Belongs to the ABC transporter superfamily
D6022_RS19365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6022_RS19370	COG0601	transmembrane transport
D6022_RS19375	COG2362	D-Aminopeptidase
D6022_RS19380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D6022_RS19385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6022_RS19395	COG0346	lactoylglutathione lyase activity
D6022_RS19400	COG0531	amino acid
D6022_RS19405	COG0395	ABC-type sugar transport system, permease component
D6022_RS19410	COG4209	transmembrane transport
D6022_RS19415	COG1653	transport
D6022_RS19425	COG1874	Beta-galactosidase
D6022_RS19430	COG2755	lipolytic protein G-D-S-L family
D6022_RS19435	COG0667	Aldo Keto reductase
D6022_RS19440	COG3401	FG-GAP repeat protein
D6022_RS19445	COG2755	lipolytic protein G-D-S-L family
D6022_RS19455	COG3401	FG-GAP repeat protein
D6022_RS19460	COG5578	integral membrane protein
D6022_RS19470	COG2755	lipolytic protein G-D-S-L family
D6022_RS19475	COG2207	Transcriptional regulator
D6022_RS19480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D6022_RS19485	COG0395	ABC-type sugar transport system, permease component
D6022_RS19490	COG1175	transmembrane transport
D6022_RS19495	COG1653	transport
D6022_RS19500	COG4753	response regulator
D6022_RS19500	COG2207	Transcriptional regulator
D6022_RS19505	COG2972	Histidine kinase
D6022_RS19510	COG5578	integral membrane protein
D6022_RS19515	COG0405	Gamma-glutamyltransferase
D6022_RS19520	COG1392	Phosphate transport regulator
D6022_RS19525	COG0306	phosphate transporter
D6022_RS19540	COG2271	Major facilitator Superfamily
D6022_RS19545	COG1063	alcohol dehydrogenase
D6022_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS19555	COG1312	Catalyzes the dehydration of D-mannonate
D6022_RS19560	COG1063	alcohol dehydrogenase
D6022_RS19565	COG1802	Transcriptional regulator
D6022_RS19600	COG3778	Protein conserved in bacteria
D6022_RS19605	COG3299	homolog of phage Mu protein gp47
D6022_RS19610	COG3628	GPW Gp25 family protein
D6022_RS19620	COG4193	domain, Protein
D6022_RS19625	COG1652	LysM domain
D6022_RS19630	COG3953	SLT domain
D6022_RS19630	COG5412	phage tail tape measure protein
D6022_RS19680	COG4653	Phage capsid family
D6022_RS19685	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D6022_RS19690	COG5518	Phage portal protein
D6022_RS19695	COG1783	phage Terminase large subunit
D6022_RS19700	COG5484	DNA packaging
D6022_RS19700	COG3728	DNA packaging
D6022_RS19705	COG1595	DNA-templated transcription, initiation
D6022_RS19720	COG1484	DNA-dependent DNA replication
D6022_RS19725	COG1522	sequence-specific DNA binding
D6022_RS19740	COG1396	sequence-specific DNA binding
D6022_RS19745	COG2856	Zn peptidase
D6022_RS19750	COG4195	phage-related replication protein
D6022_RS19755	COG5444	nuclease activity
D6022_RS19775	COG1309	transcriptional regulator
D6022_RS19780	COG2814	Major facilitator Superfamily
D6022_RS19785	COG3584	3D domain protein
D6022_RS19785	COG1388	LysM domain
D6022_RS19795	COG0346	lactoylglutathione lyase activity
D6022_RS19800	COG0697	spore germination
D6022_RS19805	COG0583	DNA-binding transcription factor activity
D6022_RS19815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6022_RS19820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D6022_RS19825	COG0583	DNA-binding transcription factor activity
D6022_RS19835	COG0110	maltose O-acetyltransferase activity
D6022_RS19855	COG3507	Belongs to the glycosyl hydrolase 43 family
D6022_RS19860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6022_RS19875	COG5505	Protein of unknown function (DUF819)
D6022_RS19880	COG0626	cystathionine gamma-synthase activity
D6022_RS19885	COG0626	cystathionine gamma-synthase activity
D6022_RS19905	COG2382	esterase
D6022_RS19910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D6022_RS19915	COG2153	protein acetylation
D6022_RS19920	COG2246	polysaccharide biosynthetic process
D6022_RS19925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D6022_RS19930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6022_RS19935	COG0586	Pfam SNARE associated Golgi protein
D6022_RS19945	COG0210	DNA helicase
D6022_RS20000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D6022_RS20005	COG0351	phosphomethylpyrimidine kinase
D6022_RS20010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D6022_RS20015	COG2022	thiamine diphosphate biosynthetic process
D6022_RS20020	COG2104	thiamine diphosphate biosynthetic process
D6022_RS20030	COG0352	thiamine-phosphate diphosphorylase activity
D6022_RS20035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D6022_RS20040	COG0569	domain protein
D6022_RS20040	COG0475	glutathione-regulated potassium exporter activity
D6022_RS20050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D6022_RS20055	COG0564	pseudouridine synthase activity
D6022_RS20060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D6022_RS20065	COG2357	RelA SpoT domain protein
D6022_RS20075	COG4116	CYTH
D6022_RS20080	COG0741	lytic transglycosylase activity
D6022_RS20085	COG2346	COG2346, Truncated hemoglobins
D6022_RS20090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D6022_RS20100	COG1164	Oligoendopeptidase f
D6022_RS20110	COG4469	Competence protein
D6022_RS20115	COG3290	protein histidine kinase activity
D6022_RS20120	COG4565	transcriptional regulatory protein
D6022_RS20140	COG4862	establishment of competence for transformation
D6022_RS20150	COG0861	Integral membrane protein TerC family
D6022_RS20155	COG1393	Belongs to the ArsC family
D6022_RS20160	COG0456	acetyltransferase
D6022_RS20165	COG4608	Belongs to the ABC transporter superfamily
D6022_RS20170	COG0444	Belongs to the ABC transporter superfamily
D6022_RS20175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6022_RS20180	COG0601	transmembrane transport
D6022_RS20185	COG4166	transmembrane transport
D6022_RS20195	COG0180	Tryptophanyl-tRNA synthetase
D6022_RS20220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6022_RS20225	COG0601	transmembrane transport
D6022_RS20235	COG4608	Belongs to the ABC transporter superfamily
D6022_RS20240	COG0444	Belongs to the ABC transporter superfamily
D6022_RS20245	COG5504	Zn-dependent protease
D6022_RS20250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6022_RS20255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6022_RS20270	COG1744	ABC transporter substrate-binding protein PnrA-like
D6022_RS20280	COG2267	carboxylic ester hydrolase activity
D6022_RS20295	COG1968	undecaprenyl-diphosphatase activity
D6022_RS20300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D6022_RS20305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D6022_RS20310	COG0505	Belongs to the CarA family
D6022_RS20315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D6022_RS20320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D6022_RS20325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D6022_RS20330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D6022_RS20340	COG2151	metal-sulfur cluster biosynthetic enzyme
D6022_RS20345	COG1073	alpha beta
D6022_RS20350	COG0561	phosphatase activity
D6022_RS20360	COG0516	GMP reductase activity
D6022_RS20370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D6022_RS20375	COG1307	EDD domain protein, DegV family
D6022_RS20390	COG2996	Protein conserved in bacteria
D6022_RS20395	COG1666	GTP binding
D6022_RS20400	COG0646	methionine synthase
D6022_RS20400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D6022_RS20405	COG0646	methionine synthase
D6022_RS20405	COG1410	methionine synthase
D6022_RS20410	COG2378	regulation of single-species biofilm formation
D6022_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS20420	COG2153	protein acetylation
D6022_RS20445	COG0076	glutamate decarboxylase activity
D6022_RS20455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6022_RS20460	COG0673	inositol 2-dehydrogenase activity
D6022_RS20465	COG1609	Transcriptional regulator
D6022_RS20475	COG1917	Cupin 2, conserved barrel domain protein
D6022_RS20475	COG2207	Transcriptional regulator
D6022_RS20480	COG0534	Mate efflux family protein
D6022_RS20485	COG0347	Belongs to the P(II) protein family
D6022_RS20495	COG0367	asparagine synthase
D6022_RS20515	COG0179	Fumarylacetoacetate (FAA) hydrolase
D6022_RS20525	COG5337	Spore coat protein CotH
D6022_RS20570	COG0419	ATPase involved in DNA repair
D6022_RS20575	COG0420	3'-5' exonuclease activity
D6022_RS20580	COG1074	ATP-dependent DNA helicase activity
D6022_RS20585	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D6022_RS20590	COG4149	molybdate abc transporter
D6022_RS20595	COG0725	ABC transporter, periplasmic molybdate-binding protein
D6022_RS20600	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D6022_RS20605	COG0745	RESPONSE REGULATOR receiver
D6022_RS20610	COG5002	protein histidine kinase activity
D6022_RS20620	COG0477	Major facilitator Superfamily
D6022_RS20620	COG2814	Major facilitator Superfamily
D6022_RS20625	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS20630	COG3546	catalase activity
D6022_RS20645	COG3180	Ammonia monooxygenase
D6022_RS20650	COG1486	melibiose metabolic process
D6022_RS20655	COG0395	ABC-type sugar transport system, permease component
D6022_RS20660	COG1175	transmembrane transport
D6022_RS20665	COG1653	transport
D6022_RS20670	COG1609	Transcriptional regulator
D6022_RS20690	COG0457	Tetratricopeptide repeat
D6022_RS20700	COG2814	Major facilitator Superfamily
D6022_RS20705	COG0549	Belongs to the carbamate kinase family
D6022_RS20715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D6022_RS20720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D6022_RS20725	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D6022_RS20730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D6022_RS20735	COG3257	ureidoglycine aminohydrolase activity
D6022_RS20740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6022_RS20745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6022_RS20755	COG2508	Transcriptional regulator
D6022_RS20765	COG1404	Belongs to the peptidase S8 family
D6022_RS20770	COG0681	Belongs to the peptidase S26 family
D6022_RS20775	COG0398	Pfam SNARE associated Golgi protein
D6022_RS20785	COG4903	ComK protein
D6022_RS20795	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS20800	COG0723	plastoquinol--plastocyanin reductase activity
D6022_RS20800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6022_RS20805	COG0840	transmembrane signaling receptor activity
D6022_RS20810	COG0406	alpha-ribazole phosphatase activity
D6022_RS20815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS20820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6022_RS20825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D6022_RS20830	COG0697	spore germination
D6022_RS20840	COG0501	Belongs to the peptidase M48B family
D6022_RS20855	COG1396	sequence-specific DNA binding
D6022_RS20865	COG0318	PFAM AMP-dependent synthetase and ligase
D6022_RS20870	COG0095	Lipoate-protein ligase
D6022_RS20875	COG1234	tRNA 3'-trailer cleavage
D6022_RS20885	COG1301	dicarboxylic acid transport
D6022_RS20895	COG1363	Peptidase, m42
D6022_RS20900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6022_RS20905	COG1511	domain protein
D6022_RS20910	COG1309	transcriptional regulator
D6022_RS20915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D6022_RS20920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D6022_RS20925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D6022_RS20930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6022_RS20935	COG2329	Antibiotic biosynthesis monooxygenase
D6022_RS20940	COG3069	C4-dicarboxylate transmembrane transporter activity
D6022_RS20945	COG1473	amidohydrolase
D6022_RS20955	COG4473	ABC transporter
D6022_RS20960	COG1131	(ABC) transporter
D6022_RS20970	COG0537	adenosine 5'-monophosphoramidase activity
D6022_RS20975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D6022_RS20990	COG4980	gas vesicle protein
D6022_RS20995	COG1846	Transcriptional regulator
D6022_RS21025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D6022_RS21035	COG3481	metal-dependent phosphohydrolase, HD sub domain
D6022_RS21045	COG0420	3'-5' exonuclease activity
D6022_RS21050	COG1668	transmembrane transport
D6022_RS21055	COG4152	abc transporter atp-binding protein
D6022_RS21070	COG0457	Tetratricopeptide repeat
D6022_RS21075	COG1024	Enoyl-CoA hydratase
D6022_RS21085	COG0490	domain, Protein
D6022_RS21090	COG0475	glutathione-regulated potassium exporter activity
D6022_RS21095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D6022_RS21100	COG0561	phosphatase activity
D6022_RS21110	COG3679	Belongs to the UPF0342 family
D6022_RS21115	COG4399	Belongs to the UPF0754 family
D6022_RS21120	COG0189	ligase activity
D6022_RS21125	COG0189	ligase activity
D6022_RS21135	COG2508	Transcriptional regulator
D6022_RS21140	COG3842	ATPase activity
D6022_RS21155	COG0702	epimerase
D6022_RS21160	COG1132	(ABC) transporter
D6022_RS21165	COG1132	(ABC) transporter
D6022_RS21170	COG0589	response to stress
D6022_RS21195	COG2017	converts alpha-aldose to the beta-anomer
D6022_RS21200	COG1757	Na H antiporter
D6022_RS21210	COG0726	polysaccharide deacetylase
D6022_RS21220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D6022_RS21225	COG0668	transmembrane transport
D6022_RS21235	COG0584	glycerophosphoryl diester phosphodiesterase
D6022_RS21240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D6022_RS21245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D6022_RS21265	COG1253	flavin adenine dinucleotide binding
D6022_RS21270	COG0789	Transcriptional regulator
D6022_RS21275	COG1253	flavin adenine dinucleotide binding
D6022_RS21280	COG1309	transcriptional regulator
D6022_RS21290	COG3152	Membrane
D6022_RS21295	COG0204	Acyl-transferase
D6022_RS21305	COG0662	Cupin 2, conserved barrel domain protein
D6022_RS21310	COG1595	DNA-templated transcription, initiation
D6022_RS21330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6022_RS21335	COG3708	Transcriptional regulator
D6022_RS21335	COG2207	Transcriptional regulator
D6022_RS21345	COG0733	neurotransmitter:sodium symporter activity
D6022_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS21355	COG2133	pyrroloquinoline quinone binding
D6022_RS21360	COG0372	Belongs to the citrate synthase family
D6022_RS21365	COG0583	DNA-binding transcription factor activity
D6022_RS21370	COG0791	NLP P60 protein
D6022_RS21370	COG1388	LysM domain
D6022_RS21375	COG2719	SpoVR family
D6022_RS21380	COG1017	nitric oxide dioxygenase activity
D6022_RS21380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D6022_RS21385	COG1959	2 iron, 2 sulfur cluster binding
D6022_RS21400	COG0431	NADPH-dependent FMN reductase
D6022_RS21405	COG2197	response regulator
D6022_RS21410	COG4585	Histidine kinase
D6022_RS21410	COG2203	Gaf domain
D6022_RS21425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D6022_RS21430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D6022_RS21435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D6022_RS21440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D6022_RS21445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D6022_RS21450	COG0604	alcohol dehydrogenase
D6022_RS21455	COG0679	Auxin Efflux Carrier
D6022_RS21460	COG2116	formate transmembrane transporter activity
D6022_RS21470	COG0488	(ABC) transporter
D6022_RS21480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D6022_RS21485	COG0517	IMP dehydrogenase activity
D6022_RS21495	COG0564	pseudouridine synthase activity
D6022_RS21500	COG3764	Sortase (surface protein transpeptidase)
D6022_RS21505	COG4085	toxin activity
D6022_RS21505	COG0737	Belongs to the 5'-nucleotidase family
D6022_RS21505	COG1525	nuclease
D6022_RS21510	COG5002	protein histidine kinase activity
D6022_RS21515	COG5577	PFAM Coat F domain
D6022_RS21540	COG1823	symporter activity
D6022_RS21545	COG1464	Belongs to the NlpA lipoprotein family
D6022_RS21550	COG2011	ABC-type metal ion transport system permease component
D6022_RS21555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D6022_RS21560	COG1278	Cold shock
D6022_RS21565	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D6022_RS21570	COG1131	(ABC) transporter
D6022_RS21575	COG1131	(ABC) transporter
D6022_RS21580	COG1131	(ABC) transporter
D6022_RS21595	COG0655	NAD(P)H dehydrogenase (quinone) activity
D6022_RS21600	COG2814	Major facilitator Superfamily
D6022_RS21605	COG1566	PFAM secretion protein HlyD family protein
D6022_RS21615	COG2718	Belongs to the UPF0229 family
D6022_RS21620	COG2766	serine protein kinase
D6022_RS21630	COG1664	Polymer-forming cytoskeletal
D6022_RS21635	COG0789	Transcriptional regulator
D6022_RS21640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D6022_RS21650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D6022_RS21655	COG3382	B3 4 domain protein
D6022_RS21665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6022_RS21685	COG1131	(ABC) transporter
D6022_RS21695	COG1476	TRANSCRIPTIONal
D6022_RS21705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6022_RS21710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6022_RS21715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D6022_RS21720	COG1116	anion transmembrane transporter activity
D6022_RS21725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D6022_RS21730	COG0710	3-dehydroquinate dehydratase activity
D6022_RS21740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D6022_RS21865	COG0582	viral genome integration into host DNA
D6022_RS21880	COG4974	Belongs to the 'phage' integrase family
D6022_RS21990	COG0735	belongs to the Fur family
D6022_RS21995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D6022_RS22000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D6022_RS22005	COG4129	membrane
D6022_RS22010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6022_RS22015	COG0601	transmembrane transport
D6022_RS22020	COG0747	negative chemotaxis
D6022_RS22025	COG4608	Belongs to the ABC transporter superfamily
D6022_RS22030	COG0444	Belongs to the ABC transporter superfamily
D6022_RS22035	COG1132	(ABC) transporter
D6022_RS22040	COG3557	Belongs to the UPF0374 family
D6022_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
D6022_RS22065	COG1194	a g-specific adenine glycosylase
D6022_RS22070	COG1988	membrane-bound metal-dependent
D6022_RS22075	COG4485	Bacterial membrane protein, YfhO
D6022_RS22085	COG0463	Glycosyl transferase, family 2
D6022_RS22115	COG2137	regulation of response to DNA damage stimulus
D6022_RS22120	COG1090	epimerase
D6022_RS22140	COG0778	Nitroreductase
D6022_RS22145	COG0384	phenazine biosynthesis protein PhzF
D6022_RS22150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D6022_RS22150	COG0392	lysyltransferase activity
D6022_RS22160	COG1051	belongs to the nudix hydrolase family
D6022_RS22170	COG1653	transport
D6022_RS22175	COG2207	Transcriptional regulator
D6022_RS22175	COG1917	Cupin 2, conserved barrel domain protein
D6022_RS22180	COG3507	Belongs to the glycosyl hydrolase 43 family
D6022_RS22190	COG2514	catechol 2,3-dioxygenase activity
D6022_RS22195	COG2259	Doxx family
D6022_RS22200	COG1733	regulation of RNA biosynthetic process
D6022_RS22215	COG1263	PTS System
D6022_RS22215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS22220	COG1737	Transcriptional regulator
D6022_RS22225	COG1486	melibiose metabolic process
D6022_RS22235	COG3284	Transcriptional regulator
D6022_RS22240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6022_RS22245	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6022_RS22255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D6022_RS22265	COG5609	conserved protein (DUF2294)
D6022_RS22270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6022_RS22275	COG3002	Belongs to the UPF0753 family
D6022_RS22280	COG0288	reversible hydration of carbon dioxide
D6022_RS22285	COG3711	transcriptional antiterminator
D6022_RS22290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS22290	COG1263	PTS System
D6022_RS22295	COG0477	Major facilitator Superfamily
D6022_RS22305	COG1819	glycosyl
D6022_RS22330	COG4637	Psort location Cytoplasmic, score
D6022_RS22335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D6022_RS22340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D6022_RS22345	COG0598	Magnesium transport protein CorA
D6022_RS22355	COG0371	Dehydrogenase
D6022_RS22360	COG0726	polysaccharide deacetylase
D6022_RS22370	COG0535	radical SAM domain protein
D6022_RS22380	COG0387	Pfam Sodium calcium exchanger
D6022_RS22395	COG1295	ribonuclease BN
D6022_RS22400	COG4980	gas vesicle protein
D6022_RS22405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6022_RS22410	COG1115	amino acid carrier protein
D6022_RS22415	COG4840	Belongs to the UPF0435 family
D6022_RS22425	COG0693	protein deglycase activity
D6022_RS22430	COG0737	Belongs to the 5'-nucleotidase family
D6022_RS22435	COG0778	Nitroreductase
D6022_RS22440	COG1733	regulation of RNA biosynthetic process
D6022_RS22445	COG0657	acetylesterase activity
D6022_RS22455	COG0673	inositol 2-dehydrogenase activity
D6022_RS22465	COG0457	Tetratricopeptide repeat
D6022_RS22465	COG0463	Glycosyl transferase, family 2
D6022_RS22470	COG1215	transferase activity, transferring glycosyl groups
D6022_RS22480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6022_RS22485	COG1045	serine acetyltransferase
D6022_RS22490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6022_RS22515	COG2188	Transcriptional regulator
D6022_RS22520	COG0366	Alpha amylase catalytic
D6022_RS22525	COG1263	PTS System
D6022_RS22525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS22530	COG1115	amino acid carrier protein
D6022_RS22540	COG1368	sulfuric ester hydrolase activity
D6022_RS22545	COG0024	Methionine aminopeptidase
D6022_RS22555	COG2258	MOSC domain
D6022_RS22560	COG1254	Belongs to the acylphosphatase family
D6022_RS22565	COG0640	Transcriptional regulator
D6022_RS22570	COG5658	integral membrane protein
D6022_RS22575	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D6022_RS22585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6022_RS22605	COG0471	metal ion transport
D6022_RS22620	COG2130	NADP-dependent
D6022_RS22625	COG0513	Belongs to the DEAD box helicase family
D6022_RS22630	COG0488	(ABC) transporter
D6022_RS22635	COG2814	Major facilitator Superfamily
D6022_RS22640	COG0789	Transcriptional regulator
D6022_RS22650	COG2124	cytochrome p450
D6022_RS22655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D6022_RS22660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D6022_RS22665	COG0156	8-amino-7-oxononanoate synthase activity
D6022_RS22670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6022_RS22675	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
D6022_RS22680	COG0523	cobalamin synthesis protein
D6022_RS22695	COG1469	GTP cyclohydrolase I activity
D6022_RS22700	COG0488	(ABC) transporter
D6022_RS22705	COG0471	metal ion transport
D6022_RS22710	COG0840	transmembrane signaling receptor activity
D6022_RS22715	COG1012	belongs to the aldehyde dehydrogenase family
D6022_RS22730	COG0217	transcriptional regulatory protein
D6022_RS22750	COG0457	Tetratricopeptide repeat
D6022_RS22755	COG3711	transcriptional antiterminator
D6022_RS22760	COG2723	6-phospho-beta-galactosidase activity
D6022_RS22765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6022_RS22765	COG2190	(PTS) system
D6022_RS22765	COG1263	PTS System
D6022_RS22775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D6022_RS22780	COG1597	lipid kinase activity
D6022_RS22785	COG1957	nucleoside hydrolase
D6022_RS22790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6022_RS22800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D6022_RS22805	COG1309	transcriptional regulator
D6022_RS22810	COG4124	Belongs to the glycosyl hydrolase 26 family
D6022_RS22825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D6022_RS22830	COG0154	amidase activity
D6022_RS22835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D6022_RS22840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6022_RS22845	COG1285	pathogenesis
D6022_RS22850	COG0363	glucosamine-6-phosphate deaminase activity
D6022_RS22855	COG3457	Alanine racemase
D6022_RS22860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D6022_RS22865	COG0626	cystathionine gamma-synthase activity
D6022_RS22870	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D6022_RS22890	COG2188	Transcriptional regulator
D6022_RS22900	COG4851	CamS sex pheromone cAM373 precursor
D6022_RS22905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D6022_RS22910	COG0210	DNA helicase
D6022_RS22915	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D6022_RS22920	COG4496	protein, YerC YecD
D6022_RS22925	COG1470	cell adhesion involved in biofilm formation
D6022_RS22930	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D6022_RS22955	COG2124	cytochrome p450
D6022_RS22970	COG0151	Belongs to the GarS family
D6022_RS22975	COG0138	bifunctional purine biosynthesis protein purh
D6022_RS22980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D6022_RS22985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D6022_RS22990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D6022_RS22995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D6022_RS23000	COG0047	phosphoribosylformylglycinamidine synthase activity
D6022_RS23005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D6022_RS23010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D6022_RS23015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D6022_RS23020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D6022_RS23025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D6022_RS23035	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D6022_RS23050	COG2252	PERMEase
D6022_RS23060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D6022_RS23060	COG0519	Catalyzes the synthesis of GMP from XMP
D6022_RS23065	COG1305	Transglutaminase-like
D6022_RS23070	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D6022_RS23075	COG0714	Associated with various cellular activities
D6022_RS23080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D6022_RS23095	COG2132	Multicopper oxidase
D6022_RS23105	COG0702	epimerase
D6022_RS23135	COG0823	Involved in the tonB-independent uptake of proteins
D6022_RS23140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D6022_RS23155	COG1846	Transcriptional regulator
D6022_RS23160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D6022_RS23165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D6022_RS23170	COG0366	Alpha amylase catalytic
D6022_RS23175	COG1554	hydrolase, family 65, central catalytic
D6022_RS23180	COG5521	maltodextrose utilization protein MalA
D6022_RS23185	COG3833	ABC-type maltose transport systems, permease component
D6022_RS23190	COG1175	transmembrane transport
D6022_RS23195	COG2182	Extracellular solute-binding protein
D6022_RS23200	COG0366	Alpha amylase catalytic
D6022_RS23205	COG1609	Transcriptional regulator
D6022_RS23215	COG0726	polysaccharide deacetylase
D6022_RS23245	COG0772	Belongs to the SEDS family
D6022_RS23250	COG3339	Conserved Protein
D6022_RS23255	COG1280	lysine exporter protein (LysE YggA)
D6022_RS23260	COG1378	Sugar-specific transcriptional regulator TrmB
D6022_RS23270	COG4260	virion core protein, lumpy skin disease virus
D6022_RS23275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D6022_RS23280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D6022_RS23285	COG1842	Phage shock protein A
D6022_RS23290	COG2814	Major facilitator Superfamily
D6022_RS23295	COG2272	Belongs to the type-B carboxylesterase lipase family
D6022_RS23300	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D6022_RS23305	COG3189	MarR family transcriptional regulator
D6022_RS23315	COG0574	Belongs to the PEP-utilizing enzyme family
D6022_RS23315	COG3848	Pyruvate phosphate dikinase
D6022_RS23320	COG1309	transcriptional regulator
D6022_RS23330	COG2135	peptidase activity
D6022_RS23350	COG2720	vancomycin resistance protein
D6022_RS23380	COG5444	nuclease activity
D6022_RS23435	COG5280	Phage tail tape measure protein TP901
D6022_RS23435	COG3953	SLT domain
D6022_RS23535	COG1988	membrane-bound metal-dependent
D6022_RS23565	COG0741	lytic transglycosylase activity
D6022_RS23565	COG0739	heme binding
D6022_RS23565	COG1196	nuclear chromosome segregation
D6022_RS23575	COG5644	endopeptidase inhibitor activity
D6022_RS23650	COG0328	RNA-DNA hybrid ribonuclease activity
D6022_RS23670	COG3209	COG3209 Rhs family protein
D6022_RS23690	COG2003	Belongs to the UPF0758 family