locus-tag	class	description
B37_RS00055	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_RS00100	COG5444	nuclease activity
B37_RS00140	COG2720	vancomycin resistance protein
B37_RS00155	COG2135	peptidase activity
B37_RS00170	COG3848	Pyruvate phosphate dikinase
B37_RS00170	COG0574	Belongs to the PEP-utilizing enzyme family
B37_RS00180	COG3189	MarR family transcriptional regulator
B37_RS00185	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B37_RS00190	COG2272	Belongs to the type-B carboxylesterase lipase family
B37_RS00195	COG2814	Major facilitator Superfamily
B37_RS00200	COG1842	Phage shock protein A
B37_RS00205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B37_RS00210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B37_RS00215	COG4260	virion core protein, lumpy skin disease virus
B37_RS00225	COG1378	Sugar-specific transcriptional regulator TrmB
B37_RS00230	COG1280	lysine exporter protein (LysE YggA)
B37_RS00235	COG3339	Conserved Protein
B37_RS00240	COG0772	Belongs to the SEDS family
B37_RS00245	COG0772	Belongs to the SEDS family
B37_RS00270	COG0726	polysaccharide deacetylase
B37_RS00280	COG1609	Transcriptional regulator
B37_RS00285	COG0366	Alpha amylase catalytic
B37_RS00290	COG2182	Extracellular solute-binding protein
B37_RS00295	COG1175	transmembrane transport
B37_RS00300	COG3833	ABC-type maltose transport systems, permease component
B37_RS00305	COG5521	maltodextrose utilization protein MalA
B37_RS00310	COG1554	hydrolase, family 65, central catalytic
B37_RS00315	COG0366	Alpha amylase catalytic
B37_RS00320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B37_RS00325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B37_RS00330	COG1846	Transcriptional regulator
B37_RS00345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B37_RS00350	COG0823	Involved in the tonB-independent uptake of proteins
B37_RS00380	COG0702	epimerase
B37_RS00390	COG2132	Multicopper oxidase
B37_RS00405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B37_RS00410	COG0714	Associated with various cellular activities
B37_RS00415	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B37_RS00420	COG1305	Transglutaminase-like
B37_RS00425	COG0519	Catalyzes the synthesis of GMP from XMP
B37_RS00425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B37_RS00435	COG2252	PERMEase
B37_RS00450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B37_RS00460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B37_RS00465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B37_RS00470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B37_RS00475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B37_RS00480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B37_RS00485	COG0047	phosphoribosylformylglycinamidine synthase activity
B37_RS00490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B37_RS00495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B37_RS00500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B37_RS00505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B37_RS00510	COG0138	bifunctional purine biosynthesis protein purh
B37_RS00515	COG0151	Belongs to the GarS family
B37_RS00530	COG2124	cytochrome p450
B37_RS00550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B37_RS00555	COG1470	cell adhesion involved in biofilm formation
B37_RS00560	COG4496	protein, YerC YecD
B37_RS00565	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B37_RS00570	COG0210	DNA helicase
B37_RS00575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B37_RS00580	COG4851	CamS sex pheromone cAM373 precursor
B37_RS00585	COG2188	Transcriptional regulator
B37_RS00605	COG1735	metal-dependent hydrolase with the TIM-barrel fold
B37_RS00610	COG0626	cystathionine gamma-synthase activity
B37_RS00615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B37_RS00620	COG3457	Alanine racemase
B37_RS00625	COG0363	glucosamine-6-phosphate deaminase activity
B37_RS00630	COG1285	pathogenesis
B37_RS00635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS00640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B37_RS00645	COG0154	amidase activity
B37_RS00650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B37_RS00665	COG4124	Belongs to the glycosyl hydrolase 26 family
B37_RS00670	COG1309	transcriptional regulator
B37_RS00675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B37_RS00685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_RS00695	COG1597	lipid kinase activity
B37_RS00700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B37_RS00705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B37_RS00730	COG3645	SOS response
B37_RS00740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B37_RS00765	COG2190	(PTS) system
B37_RS00765	COG1263	PTS System
B37_RS00765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS00770	COG2723	6-phospho-beta-galactosidase activity
B37_RS00775	COG3711	transcriptional antiterminator
B37_RS00780	COG0457	Tetratricopeptide repeat
B37_RS00800	COG0217	transcriptional regulatory protein
B37_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS00820	COG0840	transmembrane signaling receptor activity
B37_RS00825	COG0471	metal ion transport
B37_RS00830	COG0488	(ABC) transporter
B37_RS00835	COG1469	GTP cyclohydrolase I activity
B37_RS00850	COG0523	cobalamin synthesis protein
B37_RS00855	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B37_RS00860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B37_RS00865	COG0156	8-amino-7-oxononanoate synthase activity
B37_RS00870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B37_RS00875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B37_RS00880	COG2124	cytochrome p450
B37_RS00890	COG0789	Transcriptional regulator
B37_RS00895	COG2814	Major facilitator Superfamily
B37_RS00900	COG0488	(ABC) transporter
B37_RS00905	COG0513	Belongs to the DEAD box helicase family
B37_RS00910	COG2130	NADP-dependent
B37_RS00925	COG0471	metal ion transport
B37_RS00940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS00950	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B37_RS00955	COG5658	integral membrane protein
B37_RS00960	COG0640	Transcriptional regulator
B37_RS00965	COG1254	Belongs to the acylphosphatase family
B37_RS00970	COG2258	MOSC domain
B37_RS00980	COG0024	Methionine aminopeptidase
B37_RS00985	COG1368	sulfuric ester hydrolase activity
B37_RS00995	COG1115	amino acid carrier protein
B37_RS01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS01000	COG1263	PTS System
B37_RS01005	COG0366	Alpha amylase catalytic
B37_RS01010	COG2188	Transcriptional regulator
B37_RS01040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_RS01045	COG1045	serine acetyltransferase
B37_RS01050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_RS01060	COG1215	transferase activity, transferring glycosyl groups
B37_RS01065	COG0463	Glycosyl transferase, family 2
B37_RS01065	COG0457	Tetratricopeptide repeat
B37_RS01075	COG0673	inositol 2-dehydrogenase activity
B37_RS01085	COG0657	acetylesterase activity
B37_RS01090	COG1733	regulation of RNA biosynthetic process
B37_RS01095	COG0778	Nitroreductase
B37_RS01100	COG0737	Belongs to the 5'-nucleotidase family
B37_RS01105	COG0693	protein deglycase activity
B37_RS01110	COG4840	Belongs to the UPF0435 family
B37_RS01115	COG1115	amino acid carrier protein
B37_RS01120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_RS01125	COG4980	gas vesicle protein
B37_RS01130	COG1295	ribonuclease BN
B37_RS01135	COG0477	Major facilitator Superfamily
B37_RS01145	COG0387	Pfam Sodium calcium exchanger
B37_RS01155	COG0535	radical SAM domain protein
B37_RS01165	COG0726	polysaccharide deacetylase
B37_RS01170	COG0371	Dehydrogenase
B37_RS01180	COG0598	Magnesium transport protein CorA
B37_RS01185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B37_RS01190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B37_RS01195	COG4637	Psort location Cytoplasmic, score
B37_RS01220	COG1819	glycosyl
B37_RS01230	COG0477	Major facilitator Superfamily
B37_RS01235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS01235	COG1263	PTS System
B37_RS01240	COG3711	transcriptional antiterminator
B37_RS01245	COG0288	reversible hydration of carbon dioxide
B37_RS01250	COG3002	Belongs to the UPF0753 family
B37_RS01255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B37_RS01260	COG5609	conserved protein (DUF2294)
B37_RS01270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_RS01275	COG0022	dehydrogenase e1 component
B37_RS01280	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_RS01285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_RS01290	COG3284	Transcriptional regulator
B37_RS01295	COG1742	UPF0060 membrane protein
B37_RS01300	COG1486	melibiose metabolic process
B37_RS01305	COG1737	Transcriptional regulator
B37_RS01310	COG1263	PTS System
B37_RS01310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS01325	COG1733	regulation of RNA biosynthetic process
B37_RS01330	COG2259	Doxx family
B37_RS01335	COG2514	catechol 2,3-dioxygenase activity
B37_RS01345	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_RS01350	COG2207	Transcriptional regulator
B37_RS01350	COG1917	Cupin 2, conserved barrel domain protein
B37_RS01355	COG1653	transport
B37_RS01365	COG1051	belongs to the nudix hydrolase family
B37_RS01375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B37_RS01375	COG0392	lysyltransferase activity
B37_RS01380	COG0384	phenazine biosynthesis protein PhzF
B37_RS01385	COG0778	Nitroreductase
B37_RS01405	COG1090	epimerase
B37_RS01410	COG2137	regulation of response to DNA damage stimulus
B37_RS01440	COG0463	Glycosyl transferase, family 2
B37_RS01450	COG4485	Bacterial membrane protein, YfhO
B37_RS01455	COG1988	membrane-bound metal-dependent
B37_RS01460	COG1194	a g-specific adenine glycosylase
B37_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS01485	COG3557	Belongs to the UPF0374 family
B37_RS01490	COG1132	(ABC) transporter
B37_RS01495	COG0444	Belongs to the ABC transporter superfamily
B37_RS01500	COG4608	Belongs to the ABC transporter superfamily
B37_RS01505	COG0747	negative chemotaxis
B37_RS01510	COG0601	transmembrane transport
B37_RS01515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS01520	COG4129	membrane
B37_RS01525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B37_RS01530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B37_RS01535	COG0735	belongs to the Fur family
B37_RS01640	COG4974	Belongs to the 'phage' integrase family
B37_RS01765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_RS01765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_RS01780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B37_RS01810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS01820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS01825	COG0756	dUTP diphosphatase activity
B37_RS01835	COG3584	3D domain protein
B37_RS01945	COG0740	serine-type endopeptidase activity
B37_RS01995	COG3953	SLT domain
B37_RS01995	COG5280	Phage tail tape measure protein TP901
B37_RS02035	COG1388	LysM domain
B37_RS02035	COG3409	Peptidoglycan-binding domain 1 protein
B37_RS02035	COG5632	N-Acetylmuramoyl-L-alanine amidase
B37_RS02055	COG0438	transferase activity, transferring glycosyl groups
B37_RS02120	COG5444	nuclease activity
B37_RS02140	COG0457	Tetratricopeptide repeat
B37_RS02155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B37_RS02165	COG0710	3-dehydroquinate dehydratase activity
B37_RS02170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B37_RS02175	COG1116	anion transmembrane transporter activity
B37_RS02180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B37_RS02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B37_RS02190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_RS02200	COG1476	TRANSCRIPTIONal
B37_RS02210	COG1131	(ABC) transporter
B37_RS02230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_RS02240	COG3382	B3 4 domain protein
B37_RS02245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B37_RS02255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B37_RS02260	COG0789	Transcriptional regulator
B37_RS02265	COG1664	Polymer-forming cytoskeletal
B37_RS02275	COG2766	serine protein kinase
B37_RS02280	COG2718	Belongs to the UPF0229 family
B37_RS02290	COG4974	Belongs to the 'phage' integrase family
B37_RS02360	COG0457	Tetratricopeptide repeat
B37_RS02365	COG5444	nuclease activity
B37_RS02385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B37_RS02425	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_RS02425	COG3420	alginic acid biosynthetic process
B37_RS02445	COG2131	deaminase
B37_RS02450	COG2002	toxin-antitoxin pair type II binding
B37_RS02595	COG0741	lytic transglycosylase activity
B37_RS02595	COG1196	nuclear chromosome segregation
B37_RS02595	COG0739	heme binding
B37_RS02630	COG5632	N-Acetylmuramoyl-L-alanine amidase
B37_RS02660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B37_RS02670	COG2176	DNA-directed DNA polymerase activity
B37_RS02695	COG0194	GDP metabolic process
B37_RS02725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B37_RS02755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS02760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS02790	COG1566	PFAM secretion protein HlyD family protein
B37_RS02795	COG2814	Major facilitator Superfamily
B37_RS02800	COG0655	NAD(P)H dehydrogenase (quinone) activity
B37_RS02820	COG1131	(ABC) transporter
B37_RS02825	COG1131	(ABC) transporter
B37_RS02830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_RS02840	COG1278	Cold shock
B37_RS02845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B37_RS02850	COG2011	ABC-type metal ion transport system permease component
B37_RS02855	COG1464	Belongs to the NlpA lipoprotein family
B37_RS02860	COG1823	symporter activity
B37_RS02885	COG5577	PFAM Coat F domain
B37_RS02890	COG5002	protein histidine kinase activity
B37_RS02895	COG1525	nuclease
B37_RS02895	COG0737	Belongs to the 5'-nucleotidase family
B37_RS02895	COG4085	toxin activity
B37_RS02900	COG3764	Sortase (surface protein transpeptidase)
B37_RS02905	COG0564	pseudouridine synthase activity
B37_RS02915	COG0517	IMP dehydrogenase activity
B37_RS02920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B37_RS02925	COG3153	acetyltransferase
B37_RS02925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B37_RS02930	COG0488	(ABC) transporter
B37_RS02940	COG2116	formate transmembrane transporter activity
B37_RS02945	COG0679	Auxin Efflux Carrier
B37_RS02950	COG0604	alcohol dehydrogenase
B37_RS02955	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B37_RS02960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B37_RS02965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B37_RS02970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B37_RS02975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B37_RS02990	COG2203	Gaf domain
B37_RS02990	COG4585	Histidine kinase
B37_RS02995	COG2197	response regulator
B37_RS03000	COG0431	NADPH-dependent FMN reductase
B37_RS03015	COG1959	2 iron, 2 sulfur cluster binding
B37_RS03020	COG1017	nitric oxide dioxygenase activity
B37_RS03020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B37_RS03025	COG2719	SpoVR family
B37_RS03030	COG0791	NLP P60 protein
B37_RS03030	COG1388	LysM domain
B37_RS03035	COG0583	DNA-binding transcription factor activity
B37_RS03040	COG0372	Belongs to the citrate synthase family
B37_RS03045	COG2133	pyrroloquinoline quinone binding
B37_RS03050	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS03055	COG0733	neurotransmitter:sodium symporter activity
B37_RS03065	COG3708	Transcriptional regulator
B37_RS03065	COG2207	Transcriptional regulator
B37_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_RS03090	COG1595	DNA-templated transcription, initiation
B37_RS03095	COG0662	Cupin 2, conserved barrel domain protein
B37_RS03105	COG0204	Acyl-transferase
B37_RS03110	COG3152	Membrane
B37_RS03120	COG1309	transcriptional regulator
B37_RS03125	COG1253	flavin adenine dinucleotide binding
B37_RS03130	COG0789	Transcriptional regulator
B37_RS03135	COG1253	flavin adenine dinucleotide binding
B37_RS03155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B37_RS03160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B37_RS03165	COG0584	glycerophosphoryl diester phosphodiesterase
B37_RS03170	COG0668	transmembrane transport
B37_RS03175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B37_RS03190	COG0726	polysaccharide deacetylase
B37_RS03200	COG1757	Na H antiporter
B37_RS03205	COG2017	converts alpha-aldose to the beta-anomer
B37_RS03230	COG0589	response to stress
B37_RS03235	COG1132	(ABC) transporter
B37_RS03240	COG1132	(ABC) transporter
B37_RS03245	COG0702	epimerase
B37_RS03260	COG3842	ATPase activity
B37_RS03265	COG2508	Transcriptional regulator
B37_RS03275	COG0189	ligase activity
B37_RS03280	COG0189	ligase activity
B37_RS03285	COG4399	Belongs to the UPF0754 family
B37_RS03290	COG3679	Belongs to the UPF0342 family
B37_RS03300	COG0561	phosphatase activity
B37_RS03305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B37_RS03310	COG0475	glutathione-regulated potassium exporter activity
B37_RS03315	COG0490	domain, Protein
B37_RS03325	COG1024	Enoyl-CoA hydratase
B37_RS03345	COG4152	abc transporter atp-binding protein
B37_RS03350	COG1668	transmembrane transport
B37_RS03355	COG0420	3'-5' exonuclease activity
B37_RS03360	COG4717	serine-type aminopeptidase activity
B37_RS03365	COG3481	metal-dependent phosphohydrolase, HD sub domain
B37_RS03375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B37_RS03405	COG1846	Transcriptional regulator
B37_RS03410	COG4980	gas vesicle protein
B37_RS03425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B37_RS03430	COG0537	adenosine 5'-monophosphoramidase activity
B37_RS03440	COG1131	(ABC) transporter
B37_RS03445	COG4473	ABC transporter
B37_RS03455	COG1473	amidohydrolase
B37_RS03460	COG3069	C4-dicarboxylate transmembrane transporter activity
B37_RS03465	COG2329	Antibiotic biosynthesis monooxygenase
B37_RS03470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_RS03475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B37_RS03480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B37_RS03485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B37_RS03490	COG1309	transcriptional regulator
B37_RS03495	COG1511	domain protein
B37_RS03500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_RS03505	COG1363	Peptidase, m42
B37_RS03515	COG1301	dicarboxylic acid transport
B37_RS03525	COG1234	tRNA 3'-trailer cleavage
B37_RS03530	COG0095	Lipoate-protein ligase
B37_RS03535	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS03545	COG1396	sequence-specific DNA binding
B37_RS03560	COG0501	Belongs to the peptidase M48B family
B37_RS03570	COG0697	spore germination
B37_RS03575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B37_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS03585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS03590	COG0406	alpha-ribazole phosphatase activity
B37_RS03595	COG0840	transmembrane signaling receptor activity
B37_RS03600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B37_RS03600	COG0723	plastoquinol--plastocyanin reductase activity
B37_RS03605	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS03615	COG4903	ComK protein
B37_RS03625	COG0398	Pfam SNARE associated Golgi protein
B37_RS03630	COG0681	Belongs to the peptidase S26 family
B37_RS03635	COG1404	Belongs to the peptidase S8 family
B37_RS03645	COG2508	Transcriptional regulator
B37_RS03655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B37_RS03660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_RS03665	COG3257	ureidoglycine aminohydrolase activity
B37_RS03670	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B37_RS03680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_RS03685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_RS03695	COG0549	Belongs to the carbamate kinase family
B37_RS03700	COG2814	Major facilitator Superfamily
B37_RS03710	COG0457	Tetratricopeptide repeat
B37_RS03730	COG1609	Transcriptional regulator
B37_RS03735	COG1653	transport
B37_RS03740	COG1175	transmembrane transport
B37_RS03745	COG0395	ABC-type sugar transport system, permease component
B37_RS03750	COG1486	melibiose metabolic process
B37_RS03755	COG3180	Ammonia monooxygenase
B37_RS03770	COG3546	catalase activity
B37_RS03775	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS03780	COG0477	Major facilitator Superfamily
B37_RS03780	COG2814	Major facilitator Superfamily
B37_RS03790	COG5002	protein histidine kinase activity
B37_RS03795	COG0745	RESPONSE REGULATOR receiver
B37_RS03800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B37_RS03805	COG0725	ABC transporter, periplasmic molybdate-binding protein
B37_RS03810	COG4149	molybdate abc transporter
B37_RS03815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B37_RS03820	COG1074	ATP-dependent DNA helicase activity
B37_RS03825	COG0420	3'-5' exonuclease activity
B37_RS03830	COG0419	ATPase involved in DNA repair
B37_RS03875	COG5337	Spore coat protein CotH
B37_RS03885	COG0179	Fumarylacetoacetate (FAA) hydrolase
B37_RS03905	COG0367	asparagine synthase
B37_RS03915	COG0347	Belongs to the P(II) protein family
B37_RS03920	COG0534	Mate efflux family protein
B37_RS03925	COG2207	Transcriptional regulator
B37_RS03925	COG1917	Cupin 2, conserved barrel domain protein
B37_RS03935	COG1609	Transcriptional regulator
B37_RS03945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_RS03955	COG0076	glutamate decarboxylase activity
B37_RS03980	COG2153	protein acetylation
B37_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS03990	COG2378	regulation of single-species biofilm formation
B37_RS03995	COG0646	methionine synthase
B37_RS03995	COG1410	methionine synthase
B37_RS04000	COG0646	methionine synthase
B37_RS04000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B37_RS04005	COG1666	GTP binding
B37_RS04010	COG2996	Protein conserved in bacteria
B37_RS04020	COG1307	EDD domain protein, DegV family
B37_RS04025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS04035	COG0516	GMP reductase activity
B37_RS04045	COG0561	phosphatase activity
B37_RS04050	COG1073	alpha beta
B37_RS04055	COG2151	metal-sulfur cluster biosynthetic enzyme
B37_RS04065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B37_RS04070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B37_RS04075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B37_RS04080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B37_RS04085	COG0505	Belongs to the CarA family
B37_RS04090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B37_RS04095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B37_RS04100	COG1968	undecaprenyl-diphosphatase activity
B37_RS04115	COG2267	carboxylic ester hydrolase activity
B37_RS04125	COG1744	ABC transporter substrate-binding protein PnrA-like
B37_RS04140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_RS04145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B37_RS04150	COG5504	Zn-dependent protease
B37_RS04155	COG0444	Belongs to the ABC transporter superfamily
B37_RS04160	COG4608	Belongs to the ABC transporter superfamily
B37_RS04170	COG0601	transmembrane transport
B37_RS04175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS04200	COG0180	Tryptophanyl-tRNA synthetase
B37_RS04210	COG4166	transmembrane transport
B37_RS04215	COG0601	transmembrane transport
B37_RS04220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS04225	COG0444	Belongs to the ABC transporter superfamily
B37_RS04230	COG4608	Belongs to the ABC transporter superfamily
B37_RS04235	COG0456	acetyltransferase
B37_RS04240	COG1393	Belongs to the ArsC family
B37_RS04245	COG0861	Integral membrane protein TerC family
B37_RS04250	COG4862	establishment of competence for transformation
B37_RS04270	COG4565	transcriptional regulatory protein
B37_RS04275	COG3290	protein histidine kinase activity
B37_RS04280	COG4469	Competence protein
B37_RS04285	COG1164	Oligoendopeptidase f
B37_RS04295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B37_RS04300	COG2346	COG2346, Truncated hemoglobins
B37_RS04305	COG0741	lytic transglycosylase activity
B37_RS04310	COG4116	CYTH
B37_RS04320	COG2357	RelA SpoT domain protein
B37_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B37_RS04330	COG0564	pseudouridine synthase activity
B37_RS04335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B37_RS04345	COG0569	domain protein
B37_RS04345	COG0475	glutathione-regulated potassium exporter activity
B37_RS04350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B37_RS04355	COG0352	thiamine-phosphate diphosphorylase activity
B37_RS04365	COG2104	thiamine diphosphate biosynthetic process
B37_RS04370	COG2022	thiamine diphosphate biosynthetic process
B37_RS04375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B37_RS04380	COG0351	phosphomethylpyrimidine kinase
B37_RS04385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B37_RS04440	COG0210	DNA helicase
B37_RS04450	COG0586	Pfam SNARE associated Golgi protein
B37_RS04460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B37_RS04465	COG2246	polysaccharide biosynthetic process
B37_RS04470	COG2153	protein acetylation
B37_RS04475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B37_RS04480	COG2382	esterase
B37_RS04500	COG0626	cystathionine gamma-synthase activity
B37_RS04505	COG0626	cystathionine gamma-synthase activity
B37_RS04510	COG5505	Protein of unknown function (DUF819)
B37_RS04525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_RS04530	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_RS04550	COG0110	maltose O-acetyltransferase activity
B37_RS04560	COG0583	DNA-binding transcription factor activity
B37_RS04570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B37_RS04575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_RS04580	COG0583	DNA-binding transcription factor activity
B37_RS04585	COG0697	spore germination
B37_RS04590	COG0346	lactoylglutathione lyase activity
B37_RS04600	COG3584	3D domain protein
B37_RS04600	COG1388	LysM domain
B37_RS04605	COG2814	Major facilitator Superfamily
B37_RS04610	COG1309	transcriptional regulator
B37_RS04635	COG4195	phage-related replication protein
B37_RS04640	COG2856	Zn peptidase
B37_RS04645	COG1396	sequence-specific DNA binding
B37_RS04660	COG1522	sequence-specific DNA binding
B37_RS04665	COG1484	DNA-dependent DNA replication
B37_RS04680	COG1595	DNA-templated transcription, initiation
B37_RS04685	COG3728	DNA packaging
B37_RS04685	COG5484	DNA packaging
B37_RS04690	COG1783	phage Terminase large subunit
B37_RS04695	COG5518	Phage portal protein
B37_RS04700	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B37_RS04705	COG4653	Phage capsid family
B37_RS04750	COG5412	phage tail tape measure protein
B37_RS04750	COG3953	SLT domain
B37_RS04755	COG1652	LysM domain
B37_RS04760	COG4193	domain, Protein
B37_RS04770	COG3628	GPW Gp25 family protein
B37_RS04775	COG3299	homolog of phage Mu protein gp47
B37_RS04780	COG3778	Protein conserved in bacteria
B37_RS04820	COG1802	Transcriptional regulator
B37_RS04825	COG1063	alcohol dehydrogenase
B37_RS04830	COG1312	Catalyzes the dehydration of D-mannonate
B37_RS04835	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS04840	COG1063	alcohol dehydrogenase
B37_RS04845	COG2271	Major facilitator Superfamily
B37_RS04860	COG0306	phosphate transporter
B37_RS04865	COG1392	Phosphate transport regulator
B37_RS04870	COG0405	Gamma-glutamyltransferase
B37_RS04880	COG2972	Histidine kinase
B37_RS04885	COG4753	response regulator
B37_RS04885	COG2207	Transcriptional regulator
B37_RS04890	COG1653	transport
B37_RS04895	COG1175	transmembrane transport
B37_RS04900	COG0395	ABC-type sugar transport system, permease component
B37_RS04905	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B37_RS04910	COG2207	Transcriptional regulator
B37_RS04915	COG2755	lipolytic protein G-D-S-L family
B37_RS04925	COG5578	integral membrane protein
B37_RS04930	COG3401	FG-GAP repeat protein
B37_RS04940	COG2755	lipolytic protein G-D-S-L family
B37_RS04945	COG3401	FG-GAP repeat protein
B37_RS04950	COG0667	Aldo Keto reductase
B37_RS04955	COG2755	lipolytic protein G-D-S-L family
B37_RS04960	COG1874	Beta-galactosidase
B37_RS04970	COG1653	transport
B37_RS04975	COG4209	transmembrane transport
B37_RS04980	COG0395	ABC-type sugar transport system, permease component
B37_RS04985	COG0531	amino acid
B37_RS04990	COG0346	lactoylglutathione lyase activity
B37_RS05000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_RS05005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_RS05010	COG2362	D-Aminopeptidase
B37_RS05015	COG0601	transmembrane transport
B37_RS05020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS05025	COG0444	Belongs to the ABC transporter superfamily
B37_RS05030	COG4166	transmembrane transport
B37_RS05035	COG1619	proteins homologs of microcin C7 resistance protein MccF
B37_RS05040	COG4948	Mandelate Racemase Muconate Lactonizing
B37_RS05045	COG0791	NLP P60 protein
B37_RS05050	COG4608	Belongs to the ABC transporter superfamily
B37_RS05055	COG1834	amidinotransferase
B37_RS05060	COG1607	acyl-coa hydrolase
B37_RS05065	COG2323	membrane
B37_RS05070	COG3866	Pectate lyase
B37_RS05090	COG2318	DinB family
B37_RS05095	COG2076	Multidrug Resistance protein
B37_RS05100	COG2076	Multidrug Resistance protein
B37_RS05105	COG0788	formyltetrahydrofolate deformylase activity
B37_RS05110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B37_RS05115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B37_RS05120	COG1764	response to oxidative stress
B37_RS05130	COG1846	Transcriptional regulator
B37_RS05135	COG1764	response to oxidative stress
B37_RS05145	COG0590	tRNA wobble adenosine to inosine editing
B37_RS05150	COG0406	alpha-ribazole phosphatase activity
B37_RS05165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B37_RS05170	COG1404	Belongs to the peptidase S8 family
B37_RS05175	COG2239	Acts as a magnesium transporter
B37_RS05185	COG0789	Transcriptional regulator
B37_RS05195	COG1846	Transcriptional regulator
B37_RS05200	COG3285	dna ligase
B37_RS05200	COG1793	dna ligase
B37_RS05205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B37_RS05210	COG5001	Diguanylate cyclase
B37_RS05210	COG3300	MHYT domain
B37_RS05215	COG0586	Pfam SNARE associated Golgi protein
B37_RS05220	COG0861	Integral membrane protein TerC family
B37_RS05225	COG1191	sigma factor activity
B37_RS05245	COG0501	Belongs to the peptidase M48B family
B37_RS05250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_RS05255	COG0768	penicillin binding
B37_RS05270	COG3594	Acyltransferase
B37_RS05275	COG5002	protein histidine kinase activity
B37_RS05280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B37_RS05285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B37_RS05290	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B37_RS05295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B37_RS05300	COG0436	Aminotransferase
B37_RS05305	COG1850	ribulose-bisphosphate carboxylase activity
B37_RS05310	COG0235	Class ii aldolase
B37_RS05310	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B37_RS05315	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B37_RS05320	COG0346	lactoylglutathione lyase activity
B37_RS05325	COG3339	Conserved Protein
B37_RS05335	COG3852	Histidine kinase
B37_RS05340	COG1846	Transcriptional regulator
B37_RS05345	COG1360	Flagellar Motor Protein
B37_RS05350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B37_RS05355	COG0542	response to heat
B37_RS05360	COG3949	Membrane
B37_RS05365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B37_RS05370	COG0720	synthase
B37_RS05375	COG0602	queuosine metabolic process
B37_RS05380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B37_RS05390	COG3739	integral membrane protein
B37_RS05395	COG3655	Transcriptional regulator
B37_RS05430	COG4873	Protein conserved in bacteria
B37_RS05440	COG3773	Cell wall hydrolase
B37_RS05445	COG2244	polysaccharide biosynthetic process
B37_RS05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS05455	COG2217	Heavy metal translocating P-type atpase
B37_RS05460	COG0006	proline dipeptidase activity
B37_RS05470	COG1609	Transcriptional regulator
B37_RS05475	COG3711	transcriptional antiterminator
B37_RS05480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS05480	COG1263	PTS System
B37_RS05480	COG2190	(PTS) system
B37_RS05485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS05490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B37_RS05500	COG1533	DNA photolyase activity
B37_RS05505	COG0456	acetyltransferase
B37_RS05510	COG0840	transmembrane signaling receptor activity
B37_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS05520	COG2084	Dehydrogenase
B37_RS05525	COG2340	Cysteine-rich secretory protein family
B37_RS05530	COG0768	penicillin binding
B37_RS05535	COG4191	Histidine kinase
B37_RS05540	COG0436	Aminotransferase
B37_RS05545	COG1714	RDD family
B37_RS05555	COG0784	Response regulator, receiver
B37_RS05555	COG0835	chemotaxis
B37_RS05565	COG2814	Major facilitator Superfamily
B37_RS05570	COG1376	ErfK ybiS ycfS ynhG family protein
B37_RS05580	COG1408	metallophosphoesterase
B37_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS05590	COG2200	EAL domain
B37_RS05600	COG4703	Protein of unknown function (DUF1797)
B37_RS05605	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B37_RS05615	COG0517	IMP dehydrogenase activity
B37_RS05620	COG0583	DNA-binding transcription factor activity
B37_RS05625	COG0716	FMN binding
B37_RS05635	COG0716	FMN binding
B37_RS05640	COG2171	N-acyltransferase activity
B37_RS05645	COG1473	amidohydrolase
B37_RS05655	COG0450	alkyl hydroperoxide reductase
B37_RS05660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS05675	COG0746	molybdenum cofactor guanylyltransferase activity
B37_RS05680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B37_RS05685	COG0303	'Molybdopterin
B37_RS05690	COG1763	Mo-molybdopterin cofactor biosynthetic process
B37_RS05695	COG0314	molybdopterin synthase activity
B37_RS05700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B37_RS05710	COG1132	(ABC) transporter
B37_RS05715	COG1132	(ABC) transporter
B37_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B37_RS05730	COG1136	(ABC) transporter
B37_RS05735	COG0577	efflux transmembrane transporter activity
B37_RS05740	COG1349	DNA-binding transcription factor activity
B37_RS05745	COG1105	Belongs to the carbohydrate kinase PfkB family
B37_RS05750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS05750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS05750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS05770	COG0488	(ABC) transporter
B37_RS05780	COG2309	aminopeptidase activity
B37_RS05785	COG1077	Cell shape determining protein MreB Mrl
B37_RS05790	COG2002	toxin-antitoxin pair type II binding
B37_RS05795	COG3852	Histidine kinase
B37_RS05800	COG0569	domain protein
B37_RS05805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B37_RS05810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B37_RS05815	COG5503	Protein of unknown function (DUF1447)
B37_RS05820	COG0561	phosphatase activity
B37_RS05830	COG0242	peptide deformylase activity
B37_RS05840	COG0497	DNA recombination
B37_RS05845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_RS05850	COG0022	dehydrogenase e1 component
B37_RS05855	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_RS05860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_RS05865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS05875	COG1982	Orn Lys Arg decarboxylase major
B37_RS05880	COG4476	Belongs to the UPF0223 family
B37_RS05885	COG4493	Belongs to the UPF0637 family
B37_RS05895	COG0483	inositol monophosphate 1-phosphatase activity
B37_RS05915	COG1595	DNA-templated transcription, initiation
B37_RS05930	COG1217	gtp-binding protein TYPA
B37_RS05940	COG1846	Transcriptional regulator
B37_RS05945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B37_RS05950	COG4896	Protein conserved in bacteria
B37_RS05960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B37_RS05965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B37_RS05970	COG2066	Belongs to the glutaminase family
B37_RS05975	COG4838	Belongs to the UPF0358 family
B37_RS05980	COG0772	Belongs to the SEDS family
B37_RS05985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B37_RS05990	COG1612	heme a metabolic process
B37_RS05995	COG0109	protoheme IX farnesyltransferase activity
B37_RS06000	COG2010	Cytochrome c
B37_RS06000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B37_RS06005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B37_RS06010	COG1845	cytochrome c oxidase, subunit III
B37_RS06015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B37_RS06020	COG3336	cytochrome c oxidase
B37_RS06030	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B37_RS06035	COG2340	Cysteine-rich secretory protein family
B37_RS06050	COG3679	Belongs to the UPF0342 family
B37_RS06055	COG4471	UPF0298 protein
B37_RS06060	COG0742	ribosomal rna small subunit methyltransferase
B37_RS06065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B37_RS06070	COG3314	Sporulation integral membrane protein YlbJ
B37_RS06075	COG3480	Lon protease (S16) C-terminal proteolytic domain
B37_RS06080	COG1323	Belongs to the UPF0348 family
B37_RS06085	COG1399	metal-binding, possibly nucleic acid-binding protein
B37_RS06090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B37_RS06100	COG0454	-acetyltransferase
B37_RS06105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B37_RS06110	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B37_RS06115	COG2001	Belongs to the MraZ family
B37_RS06120	COG0275	rRNA processing
B37_RS06125	COG4839	cell division protein FtsL
B37_RS06130	COG0768	penicillin binding
B37_RS06135	COG0768	penicillin binding
B37_RS06145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B37_RS06150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B37_RS06155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B37_RS06160	COG0772	Belongs to the SEDS family
B37_RS06165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_RS06170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B37_RS06175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B37_RS06180	COG3879	Bacterial protein of unknown function (DUF881)
B37_RS06185	COG3879	Bacterial protein of unknown function (DUF881)
B37_RS06190	COG3856	small basic protein
B37_RS06195	COG0849	cell division
B37_RS06200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B37_RS06205	COG4412	M6 family metalloprotease domain protein
B37_RS06205	COG1404	Belongs to the peptidase S8 family
B37_RS06225	COG1191	sigma factor activity
B37_RS06230	COG1191	sigma factor activity
B37_RS06240	COG0500	methyltransferase
B37_RS06245	COG1873	PFAM PRC-barrel domain
B37_RS06250	COG1496	oxidoreductase activity
B37_RS06255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B37_RS06260	COG1799	cell septum assembly
B37_RS06265	COG0762	integral membrane protein
B37_RS06270	COG2302	S4 RNA-binding domain
B37_RS06275	COG3599	regulation of cell shape
B37_RS06280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B37_RS06285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_RS06290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B37_RS06295	COG0564	pseudouridine synthase activity
B37_RS06300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B37_RS06305	COG2233	PERMEase
B37_RS06310	COG0540	Belongs to the ATCase OTCase family
B37_RS06315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B37_RS06320	COG0505	Belongs to the CarA family
B37_RS06325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B37_RS06330	COG0543	2 iron, 2 sulfur cluster binding
B37_RS06335	COG0167	dihydroorotate dehydrogenase activity
B37_RS06340	COG0284	orotidine-5'-phosphate decarboxylase activity
B37_RS06345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B37_RS06355	COG0175	sulfate reduction
B37_RS06360	COG0306	phosphate transporter
B37_RS06365	COG2046	Belongs to the sulfate adenylyltransferase family
B37_RS06370	COG0529	Catalyzes the synthesis of activated sulfate
B37_RS06375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B37_RS06380	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B37_RS06385	COG1648	precorrin-2 dehydrogenase activity
B37_RS06395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B37_RS06400	COG1561	YicC-like family, N-terminal region
B37_RS06405	COG2052	Domain of unknown function (DUF370)
B37_RS06410	COG0194	GDP metabolic process
B37_RS06415	COG1758	RNA polymerase activity
B37_RS06420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B37_RS06425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B37_RS06430	COG0242	peptide deformylase activity
B37_RS06435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B37_RS06440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B37_RS06440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B37_RS06445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B37_RS06450	COG0631	protein serine/threonine phosphatase activity
B37_RS06455	COG0515	serine threonine protein kinase
B37_RS06455	COG2815	serine threonine protein kinase
B37_RS06460	COG1162	GTPase activity
B37_RS06465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B37_RS06470	COG1564	THIamine pyrophosphokinase
B37_RS06480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B37_RS06485	COG1302	Protein conserved in bacteria
B37_RS06490	COG1461	Dihydroxyacetone kinase
B37_RS06495	COG1760	l-serine dehydratase
B37_RS06500	COG1760	l-serine dehydratase
B37_RS06505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B37_RS06510	COG1349	DNA-binding transcription factor activity
B37_RS06515	COG0416	fatty acid biosynthetic process
B37_RS06520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B37_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS06530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B37_RS06535	COG0571	ribonuclease III activity
B37_RS06540	COG1196	nuclear chromosome segregation
B37_RS06545	COG0552	protein localization to endoplasmic reticulum
B37_RS06550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B37_RS06555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B37_RS06560	COG0228	four-way junction DNA binding
B37_RS06565	COG1837	Belongs to the UPF0109 family
B37_RS06575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B37_RS06580	COG0336	Belongs to the RNA methyltransferase TrmD family
B37_RS06585	COG0335	large ribosomal subunit rRNA binding
B37_RS06590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B37_RS06595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B37_RS06605	COG2257	FlhB HrpN YscU SpaS Family
B37_RS06610	COG0045	succinate-CoA ligase (ADP-forming) activity
B37_RS06615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_RS06620	COG0758	DNA mediated transformation
B37_RS06625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B37_RS06630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B37_RS06635	COG4974	Belongs to the 'phage' integrase family
B37_RS06640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B37_RS06645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B37_RS06650	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B37_RS06655	COG1815	bacterial-type flagellum-dependent cell motility
B37_RS06660	COG1558	bacterial-type flagellum-dependent cell motility
B37_RS06665	COG1677	Flagellar hook-basal body complex protein FliE
B37_RS06670	COG1766	The M ring may be actively involved in energy transduction
B37_RS06675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_RS06680	COG1317	bacterial-type flagellum organization
B37_RS06685	COG1157	protein secretion by the type III secretion system
B37_RS06690	COG2882	bacterial-type flagellum organization
B37_RS06700	COG3144	bacterial-type flagellum assembly
B37_RS06705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B37_RS06710	COG4786	Flagellar basal body rod
B37_RS06715	COG1582	Flagellar protein (FlbD)
B37_RS06720	COG1580	Controls the rotational direction of flagella during chemotaxis
B37_RS06725	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_RS06730	COG1776	CheC inhibitor of MCP methylation
B37_RS06730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_RS06735	COG2201	protein-glutamate methylesterase activity
B37_RS06740	COG3190	flagellar
B37_RS06745	COG1338	Plays a role in the flagellum-specific transport system
B37_RS06750	COG1987	bacterial-type flagellum assembly
B37_RS06755	COG1684	flagellar biosynthetic protein fliR
B37_RS06760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B37_RS06765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B37_RS06770	COG1419	protein localization to endoplasmic reticulum
B37_RS06775	COG0455	bacterial-type flagellum organization
B37_RS06780	COG2201	protein-glutamate methylesterase activity
B37_RS06785	COG2198	Histidine kinase
B37_RS06785	COG0643	Histidine kinase
B37_RS06790	COG0835	chemotaxis
B37_RS06795	COG1776	CheC inhibitor of MCP methylation
B37_RS06800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B37_RS06805	COG1191	sigma factor activity
B37_RS06815	COG0052	Belongs to the universal ribosomal protein uS2 family
B37_RS06820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B37_RS06825	COG0528	UMP kinase activity
B37_RS06830	COG0233	cytoplasmic translational termination
B37_RS06835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B37_RS06840	COG4589	Belongs to the CDS family
B37_RS06845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B37_RS06850	COG0750	zinc metalloprotease
B37_RS06855	COG0442	prolyl-tRNA aminoacylation
B37_RS06860	COG2176	DNA-directed DNA polymerase activity
B37_RS06890	COG0779	Required for maturation of 30S ribosomal subunits
B37_RS06895	COG0195	Participates in both transcription termination and antitermination
B37_RS06900	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B37_RS06905	COG1358	cellular component organization or biogenesis
B37_RS06910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B37_RS06915	COG1550	Protein conserved in bacteria
B37_RS06920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B37_RS06925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B37_RS06930	COG0196	riboflavin kinase activity
B37_RS06935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B37_RS06940	COG1185	polyribonucleotide nucleotidyltransferase activity
B37_RS06945	COG0726	polysaccharide deacetylase
B37_RS06950	COG0612	Peptidase, M16
B37_RS06955	COG1873	PFAM PRC-barrel domain
B37_RS06960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_RS06965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B37_RS06970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B37_RS06975	COG0527	aspartate kinase activity
B37_RS06985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B37_RS06990	COG0740	serine-type endopeptidase activity
B37_RS07000	COG1674	ftsk spoiiie
B37_RS07000	COG4980	gas vesicle protein
B37_RS07005	COG2188	Transcriptional regulator
B37_RS07010	COG2814	Major facilitator Superfamily
B37_RS07015	COG0612	Peptidase, M16
B37_RS07020	COG0612	Peptidase, M16
B37_RS07025	COG0300	oxidoreductase activity
B37_RS07040	COG1426	Protein conserved in bacteria
B37_RS07045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B37_RS07050	COG1058	Belongs to the CinA family
B37_RS07050	COG1546	Belongs to the CinA family
B37_RS07060	COG1418	mRNA catabolic process
B37_RS07065	COG1692	metallophosphoesterase
B37_RS07070	COG2359	stage V sporulation protein S
B37_RS07080	COG1063	alcohol dehydrogenase
B37_RS07085	COG0156	8-amino-7-oxononanoate synthase activity
B37_RS07090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B37_RS07095	COG4550	Control of competence regulator ComK, YlbF/YmcA
B37_RS07105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B37_RS07110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B37_RS07115	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B37_RS07120	COG5444	nuclease activity
B37_RS07140	COG0523	cobalamin synthesis protein
B37_RS07150	COG1247	-acetyltransferase
B37_RS07165	COG1231	oxidoreductase activity
B37_RS07170	COG3619	membrane
B37_RS07175	COG3263	regulation of cellular component size
B37_RS07185	COG2267	carboxylic ester hydrolase activity
B37_RS07195	COG0393	Putative heavy-metal-binding
B37_RS07200	COG0398	Pfam SNARE associated Golgi protein
B37_RS07205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_RS07210	COG1819	glycosyl
B37_RS07215	COG0531	amino acid
B37_RS07220	COG5577	PFAM Coat F domain
B37_RS07230	COG1388	LysM domain
B37_RS07230	COG3858	chitin binding
B37_RS07235	COG1309	transcriptional regulator
B37_RS07240	COG3631	Ketosteroid isomerase-related protein
B37_RS07245	COG0702	epimerase
B37_RS07255	COG1764	response to oxidative stress
B37_RS07260	COG2076	Multidrug Resistance protein
B37_RS07265	COG2076	Multidrug Resistance protein
B37_RS07280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B37_RS07285	COG1923	regulation of RNA biosynthetic process
B37_RS07300	COG1780	Probably involved in ribonucleotide reductase function
B37_RS07305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS07310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_RS07315	COG4112	unkown
B37_RS07325	COG0822	iron-sulfur transferase activity
B37_RS07330	COG0735	belongs to the Fur family
B37_RS07335	COG1802	Transcriptional regulator
B37_RS07340	COG0697	spore germination
B37_RS07375	COG1309	transcriptional regulator
B37_RS07410	COG4282	regulation of fungal-type cell wall biogenesis
B37_RS07415	COG5444	nuclease activity
B37_RS07435	COG0464	growth
B37_RS07440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B37_RS07445	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B37_RS07450	COG0789	Transcriptional regulator
B37_RS07455	COG0174	glutamine synthetase
B37_RS07535	COG1309	transcriptional regulator
B37_RS07540	COG2076	Multidrug Resistance protein
B37_RS07545	COG2076	Multidrug Resistance protein
B37_RS07570	COG3546	catalase activity
B37_RS07595	COG1846	Transcriptional regulator
B37_RS07605	COG0346	lactoylglutathione lyase activity
B37_RS07610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B37_RS07615	COG0655	NAD(P)H dehydrogenase (quinone) activity
B37_RS07635	COG3209	COG3209 Rhs family protein
B37_RS07640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B37_RS07645	COG1388	LysM domain
B37_RS07650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B37_RS07655	COG4224	UPF0291 protein
B37_RS07660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B37_RS07670	COG3763	UPF0154 protein
B37_RS07680	COG0785	Cytochrome C biogenesis protein
B37_RS07685	COG2201	protein-glutamate methylesterase activity
B37_RS07690	COG4846	Membrane protein involved in cytochrome C biogenesis
B37_RS07700	COG0071	Belongs to the small heat shock protein (HSP20) family
B37_RS07715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B37_RS07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS07740	COG0824	Thioesterase
B37_RS07765	COG4841	protein insertion into membrane
B37_RS07770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B37_RS07775	COG1832	CoA-binding protein
B37_RS07780	COG0187	DNA topoisomerase II activity
B37_RS07785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B37_RS07790	COG1609	Transcriptional regulator
B37_RS07805	COG2160	L-arabinose isomerase activity
B37_RS07825	COG1115	amino acid carrier protein
B37_RS07835	COG2181	nitrate reductase activity
B37_RS07840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B37_RS07845	COG1140	nitrate reductase beta subunit
B37_RS07850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B37_RS07865	COG0535	radical SAM domain protein
B37_RS07870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B37_RS07880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B37_RS07885	COG2223	nitrite transmembrane transporter activity
B37_RS07905	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B37_RS07915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B37_RS07925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_RS07935	COG0492	ferredoxin-NADP+ reductase activity
B37_RS07950	COG3420	alginic acid biosynthetic process
B37_RS07955	COG1114	Component of the transport system for branched-chain amino acids
B37_RS07960	COG1064	alcohol dehydrogenase
B37_RS07965	COG0789	Transcriptional regulator
B37_RS07990	COG1024	Enoyl-CoA hydratase
B37_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS08000	COG2084	Dehydrogenase
B37_RS08005	COG1960	acyl-CoA dehydrogenase activity
B37_RS08010	COG1482	cell wall glycoprotein biosynthetic process
B37_RS08015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS08015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS08015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS08035	COG3711	transcriptional antiterminator
B37_RS08035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS08050	COG1725	Transcriptional regulator
B37_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS08060	COG1312	Catalyzes the dehydration of D-mannonate
B37_RS08075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B37_RS08085	COG1609	Transcriptional regulator
B37_RS08090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_RS08095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B37_RS08100	COG0640	Transcriptional regulator
B37_RS08110	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B37_RS08125	COG1649	PFAM Uncharacterised BCR, COG1649
B37_RS08135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B37_RS08145	COG2027	D-alanyl-D-alanine carboxypeptidase
B37_RS08150	COG2323	membrane
B37_RS08155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_RS08165	COG2323	membrane
B37_RS08180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_RS08195	COG3546	catalase activity
B37_RS08215	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS08235	COG1252	NADH dehydrogenase
B37_RS08250	COG0166	Belongs to the GPI family
B37_RS08260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_RS08265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B37_RS08270	COG1024	Enoyl-CoA hydratase
B37_RS08275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B37_RS08280	COG0511	ligase activity, forming carbon-carbon bonds
B37_RS08285	COG0439	Biotin carboxylase
B37_RS08290	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS08295	COG1960	acyl-CoA dehydrogenase activity
B37_RS08300	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_RS08305	COG1733	regulation of RNA biosynthetic process
B37_RS08310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B37_RS08315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B37_RS08325	COG2323	membrane
B37_RS08330	COG0306	phosphate transporter
B37_RS08335	COG0175	sulfate reduction
B37_RS08340	COG1809	phosphosulfolactate synthase activity
B37_RS08345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS08350	COG4948	Mandelate Racemase Muconate Lactonizing
B37_RS08355	COG2814	Major facilitator Superfamily
B37_RS08360	COG0463	Glycosyl transferase, family 2
B37_RS08375	COG0493	'glutamate synthase
B37_RS08380	COG0070	glutamate synthase
B37_RS08380	COG0067	glutamate synthase
B37_RS08380	COG0069	glutamate synthase activity
B37_RS08385	COG0583	DNA-binding transcription factor activity
B37_RS08405	COG1846	Transcriptional regulator
B37_RS08415	COG1132	(ABC) transporter
B37_RS08425	COG0300	oxidoreductase activity
B37_RS08440	COG0477	Major facilitator Superfamily
B37_RS08445	COG0243	molybdopterin cofactor binding
B37_RS08450	COG1846	Transcriptional regulator
B37_RS08455	COG2814	Major facilitator Superfamily
B37_RS08460	COG0531	amino acid
B37_RS08470	COG0531	amino acid
B37_RS08475	COG0531	amino acid
B37_RS08480	COG0697	spore germination
B37_RS08485	COG0488	(ABC) transporter
B37_RS08490	COG0840	transmembrane signaling receptor activity
B37_RS08495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_RS08500	COG1404	Belongs to the peptidase S8 family
B37_RS08510	COG1309	transcriptional regulator
B37_RS08515	COG1846	Transcriptional regulator
B37_RS08545	COG1309	transcriptional regulator
B37_RS08550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS08555	COG3708	Transcriptional regulator
B37_RS08565	COG2378	regulation of single-species biofilm formation
B37_RS08575	COG0640	Transcriptional regulator
B37_RS08580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS08590	COG0531	amino acid
B37_RS08595	COG0741	lytic transglycosylase activity
B37_RS08600	COG1086	Polysaccharide biosynthesis protein
B37_RS08620	COG2322	membrane
B37_RS08635	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS08640	COG3584	3D domain protein
B37_RS08640	COG1388	LysM domain
B37_RS08645	COG0514	ATP-dependent DNA helicase (RecQ)
B37_RS08665	COG2315	Protein conserved in bacteria
B37_RS08685	COG2427	Protein of unknown function (DUF1641)
B37_RS08690	COG3383	formate dehydrogenase (NAD+) activity
B37_RS08705	COG5444	nuclease activity
B37_RS08715	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B37_RS08760	COG0402	S-adenosylhomocysteine deaminase activity
B37_RS08775	COG2267	carboxylic ester hydrolase activity
B37_RS08790	COG1280	lysine exporter protein (LysE YggA)
B37_RS08795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_RS08805	COG3848	Pyruvate phosphate dikinase
B37_RS08805	COG0574	Belongs to the PEP-utilizing enzyme family
B37_RS08810	COG1309	transcriptional regulator
B37_RS08825	COG2318	DinB family
B37_RS08830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B37_RS08835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS08855	COG2814	Major facilitator Superfamily
B37_RS08870	COG1657	PFAM Prenyltransferase squalene oxidase
B37_RS08875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B37_RS08885	COG0733	neurotransmitter:sodium symporter activity
B37_RS08890	COG0385	Bile acid
B37_RS08895	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_RS08900	COG0567	Dehydrogenase, E1 component
B37_RS08905	COG4548	von Willebrand factor, type A
B37_RS08910	COG0714	Associated with various cellular activities
B37_RS08915	COG2032	superoxide dismutase activity
B37_RS08920	COG1388	LysM domain
B37_RS08920	COG0791	NLP P60 protein
B37_RS08930	COG0534	Mate efflux family protein
B37_RS08935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_RS08940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_RS08950	COG2962	Rard protein
B37_RS08960	COG4305	rare lipoprotein A
B37_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS08975	COG1733	regulation of RNA biosynthetic process
B37_RS08980	COG0778	Nitroreductase
B37_RS08985	COG0400	carboxylic ester hydrolase activity
B37_RS08995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS09005	COG3409	Peptidoglycan-binding domain 1 protein
B37_RS09005	COG0793	Belongs to the peptidase S41A family
B37_RS09010	COG2226	methyltransferase
B37_RS09020	COG1876	peptidase activity
B37_RS09025	COG0813	purine-nucleoside phosphorylase activity
B37_RS09030	COG0701	Predicted permease
B37_RS09045	COG0671	phosphoesterase, PA-phosphatase related
B37_RS09060	COG4479	Belongs to the UPF0346 family
B37_RS09070	COG1509	lysine 2,3-aminomutase activity
B37_RS09075	COG0456	acetyltransferase
B37_RS09080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_RS09085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B37_RS09090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B37_RS09095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B37_RS09110	COG0456	acetyltransferase
B37_RS09115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B37_RS09120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B37_RS09125	COG1846	Transcriptional regulator
B37_RS09135	COG3706	GGDEF domain
B37_RS09140	COG0534	Mate efflux family protein
B37_RS09155	COG4698	Protein conserved in bacteria
B37_RS09160	COG2755	lipolytic protein G-D-S-L family
B37_RS09165	COG1999	signal sequence binding
B37_RS09180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B37_RS09185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B37_RS09190	COG1272	protein, Hemolysin III
B37_RS09195	COG0204	Acyl-transferase
B37_RS09200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B37_RS09205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B37_RS09215	COG2136	Putative SAM-dependent methyltransferase
B37_RS09215	COG2521	methyltransferase
B37_RS09225	COG0129	dihydroxy-acid dehydratase activity
B37_RS09230	COG1413	lyase activity
B37_RS09235	COG1418	mRNA catabolic process
B37_RS09240	COG0386	Belongs to the glutathione peroxidase family
B37_RS09245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B37_RS09250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B37_RS09255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_RS09265	COG1278	Cold shock
B37_RS09285	COG0328	RNA-DNA hybrid ribonuclease activity
B37_RS09290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B37_RS09295	COG0328	RNA-DNA hybrid ribonuclease activity
B37_RS09305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_RS09325	COG1755	Isoprenylcysteine carboxyl methyltransferase
B37_RS09330	COG3424	synthase
B37_RS09335	COG0456	acetyltransferase
B37_RS09340	COG2233	PERMEase
B37_RS09345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_RS09350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B37_RS09355	COG1199	ATP-dependent helicase activity
B37_RS09365	COG0116	Belongs to the methyltransferase superfamily
B37_RS09375	COG3599	regulation of cell shape
B37_RS09380	COG4474	Belongs to the UPF0398 family
B37_RS09390	COG3359	exonuclease
B37_RS09395	COG1111	helicase
B37_RS09395	COG1205	dead DEAH box helicase
B37_RS09400	COG2190	(PTS) system
B37_RS09405	COG0071	Belongs to the small heat shock protein (HSP20) family
B37_RS09440	COG3331	DNA recombination
B37_RS09445	COG4499	WXG100 protein secretion system (Wss), protein YukC
B37_RS09445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_RS09455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B37_RS09460	COG3935	DnaD domain protein
B37_RS09465	COG0017	Asparaginyl-tRNA synthetase
B37_RS09470	COG0436	Aminotransferase
B37_RS09475	COG5353	protein conserved in bacteria
B37_RS09485	COG1199	ATP-dependent helicase activity
B37_RS09485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B37_RS09490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B37_RS09495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B37_RS09500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B37_RS09515	COG0617	tRNA 3'-terminal CCA addition
B37_RS09520	COG0438	transferase activity, transferring glycosyl groups
B37_RS09525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_RS09530	COG1803	Methylglyoxal synthase
B37_RS09535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B37_RS09540	COG1694	Mazg nucleotide pyrophosphohydrolase
B37_RS09545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS09555	COG4347	Protein of unknown function (DUF1405)
B37_RS09560	COG2010	Cytochrome c
B37_RS09560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B37_RS09565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B37_RS09570	COG0723	plastoquinol--plastocyanin reductase activity
B37_RS09580	COG5582	Belongs to the UPF0302 family
B37_RS09585	COG0457	Tetratricopeptide repeat
B37_RS09590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B37_RS09595	COG0287	Prephenate dehydrogenase
B37_RS09600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B37_RS09605	COG0159	tryptophan synthase activity
B37_RS09610	COG0133	tryptophan synthase activity
B37_RS09615	COG0135	phosphoribosylanthranilate isomerase activity
B37_RS09620	COG0134	indole-3-glycerol-phosphate synthase activity
B37_RS09625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_RS09630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B37_RS09635	COG4401	Chorismate mutase type I
B37_RS09640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B37_RS09645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B37_RS09650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B37_RS09655	COG0105	UTP biosynthetic process
B37_RS09660	COG0142	geranyltranstransferase activity
B37_RS09665	COG2226	methyltransferase
B37_RS09670	COG0142	geranyltranstransferase activity
B37_RS09685	COG0776	regulation of translation
B37_RS09690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B37_RS09710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B37_RS09715	COG1160	GTP binding
B37_RS09740	COG1304	FMN binding
B37_RS09745	COG0539	negative regulation of cytoplasmic translation
B37_RS09750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B37_RS09755	COG2959	enzyme of heme biosynthesis
B37_RS09760	COG3409	Peptidoglycan-binding domain 1 protein
B37_RS09760	COG3773	Cell wall hydrolase
B37_RS09765	COG2339	peptidase activity
B37_RS09775	COG0492	ferredoxin-NADP+ reductase activity
B37_RS09780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B37_RS09785	COG4862	establishment of competence for transformation
B37_RS09790	COG1408	metallophosphoesterase
B37_RS09800	COG1388	LysM domain
B37_RS09805	COG1266	CAAX protease self-immunity
B37_RS09810	COG0514	ATP-dependent DNA helicase (RecQ)
B37_RS09815	COG4955	Helix-turn-helix domain
B37_RS09820	COG1141	Ferredoxin
B37_RS09825	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B37_RS09830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B37_RS09835	COG0739	heme binding
B37_RS09845	COG1595	DNA-templated transcription, initiation
B37_RS09850	COG1316	TRANSCRIPTIONal
B37_RS09865	COG5002	protein histidine kinase activity
B37_RS09870	COG0745	RESPONSE REGULATOR receiver
B37_RS09875	COG5002	protein histidine kinase activity
B37_RS09880	COG0745	RESPONSE REGULATOR receiver
B37_RS09885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B37_RS09890	COG1333	cytochrome c biogenesis protein
B37_RS09895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS09900	COG1187	pseudouridine synthase activity
B37_RS09905	COG0700	Nucleoside recognition
B37_RS09910	COG2715	membrane protein required for spore maturation
B37_RS09915	COG1686	Belongs to the peptidase S11 family
B37_RS09925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B37_RS09930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B37_RS09940	COG1547	Domain of unknown function (DUF309)
B37_RS09945	COG0456	acetyltransferase
B37_RS09950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B37_RS09955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B37_RS09955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B37_RS09960	COG0307	riboflavin synthase, alpha
B37_RS09965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B37_RS09965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B37_RS09990	COG0457	Tetratricopeptide repeat
B37_RS09995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B37_RS10000	COG4086	secreted protein
B37_RS10005	COG4195	phage-related replication protein
B37_RS10010	COG0019	diaminopimelate decarboxylase activity
B37_RS10020	COG0697	spore germination
B37_RS10035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_RS10060	COG2172	sigma factor antagonist activity
B37_RS10070	COG1686	Belongs to the peptidase S11 family
B37_RS10075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B37_RS10080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B37_RS10085	COG4974	Belongs to the 'phage' integrase family
B37_RS10095	COG0735	belongs to the Fur family
B37_RS10100	COG1300	Membrane
B37_RS10105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS10130	COG2153	protein acetylation
B37_RS10135	COG1379	DNA repair
B37_RS10140	COG0494	nUDIX hydrolase
B37_RS10150	COG1309	transcriptional regulator
B37_RS10160	COG0667	Aldo Keto reductase
B37_RS10170	COG1073	alpha beta
B37_RS10180	COG4918	Iron-sulphur cluster biosynthesis
B37_RS10190	COG0456	acetyltransferase
B37_RS10190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B37_RS10195	COG2329	Antibiotic biosynthesis monooxygenase
B37_RS10205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B37_RS10215	COG0747	negative chemotaxis
B37_RS10220	COG0601	transmembrane transport
B37_RS10225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS10230	COG0444	Belongs to the ABC transporter superfamily
B37_RS10235	COG0534	Mate efflux family protein
B37_RS10250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B37_RS10260	COG2211	Major facilitator Superfamily
B37_RS10265	COG0346	lactoylglutathione lyase activity
B37_RS10270	COG1072	(Pantothenic acid kinase))
B37_RS10285	COG1131	(ABC) transporter
B37_RS10305	COG4195	phage-related replication protein
B37_RS10315	COG0300	oxidoreductase activity
B37_RS10320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS10325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_RS10330	COG4187	Peptidase family M20/M25/M40
B37_RS10335	COG1902	pentaerythritol trinitrate reductase activity
B37_RS10345	COG0596	Alpha beta hydrolase
B37_RS10350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B37_RS10355	COG1234	tRNA 3'-trailer cleavage
B37_RS10360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B37_RS10375	COG2358	TRAP transporter, solute receptor (TAXI family
B37_RS10380	COG2188	Transcriptional regulator
B37_RS10385	COG2723	6-phospho-beta-galactosidase activity
B37_RS10390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS10395	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_RS10400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS10405	COG1785	Belongs to the alkaline phosphatase family
B37_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS10415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B37_RS10420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B37_RS10430	COG0706	membrane insertase activity
B37_RS10435	COG2195	Cleaves the N-terminal amino acid of tripeptides
B37_RS10440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B37_RS10445	COG4129	membrane
B37_RS10450	COG1126	abc transporter atp-binding protein
B37_RS10455	COG0765	amino acid transport
B37_RS10460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_RS10470	COG1597	lipid kinase activity
B37_RS10475	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_RS10480	COG0022	dehydrogenase e1 component
B37_RS10485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_RS10490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_RS10495	COG3426	butyrate kinase activity
B37_RS10505	COG0280	phosphate acetyltransferase
B37_RS10510	COG3290	protein histidine kinase activity
B37_RS10510	COG3829	transcription factor binding
B37_RS10520	COG0584	glycerophosphoryl diester phosphodiesterase
B37_RS10525	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS10540	COG1045	serine acetyltransferase
B37_RS10550	COG0745	RESPONSE REGULATOR receiver
B37_RS10555	COG0750	zinc metalloprotease
B37_RS10560	COG0497	DNA recombination
B37_RS10565	COG1438	arginine binding
B37_RS10570	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B37_RS10575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B37_RS10580	COG0142	geranyltranstransferase activity
B37_RS10585	COG1722	exodeoxyribonuclease VII activity
B37_RS10590	COG1570	exodeoxyribonuclease VII activity
B37_RS10595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B37_RS10600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B37_RS10605	COG1302	Protein conserved in bacteria
B37_RS10610	COG0439	Biotin carboxylase
B37_RS10615	COG0511	ligase activity, forming carbon-carbon bonds
B37_RS10655	COG3854	ATPases associated with a variety of cellular activities
B37_RS10665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B37_RS10670	COG0006	proline dipeptidase activity
B37_RS10675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B37_RS10685	COG3872	metal-dependent enzyme
B37_RS10695	COG1752	Esterase of the alpha-beta hydrolase superfamily
B37_RS10700	COG1321	iron dependent repressor
B37_RS10705	COG0095	Lipoate-protein ligase
B37_RS10710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_RS10715	COG2113	Glycine betaine
B37_RS10720	COG4176	ABC-type proline glycine betaine transport system permease component
B37_RS10725	COG4175	Glycine betaine
B37_RS10725	COG0517	IMP dehydrogenase activity
B37_RS10730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B37_RS10735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B37_RS10740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B37_RS10745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B37_RS10770	COG0681	Belongs to the peptidase S26 family
B37_RS10795	COG4940	Competence protein ComGF
B37_RS10805	COG4970	Tfp pilus assembly protein FimT
B37_RS10810	COG4537	Required for transformation and DNA binding
B37_RS10815	COG1459	type II secretion system
B37_RS10820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B37_RS10825	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_RS10835	COG1393	Belongs to the ArsC family
B37_RS10845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS10855	COG0011	TIGRFAM Protein of
B37_RS10865	COG2866	Carboxypeptidase
B37_RS10870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS10875	COG1368	sulfuric ester hydrolase activity
B37_RS10880	COG1940	carbohydrate kinase activity
B37_RS10885	COG4483	Protein conserved in bacteria
B37_RS10890	COG0697	spore germination
B37_RS10895	COG0457	Tetratricopeptide repeat
B37_RS10895	COG0705	Rhomboid family
B37_RS10900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B37_RS10905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B37_RS10910	COG0438	transferase activity, transferring glycosyl groups
B37_RS10925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B37_RS10930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B37_RS10935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B37_RS10940	COG0581	inorganic phosphate transmembrane transporter activity
B37_RS10945	COG0573	inorganic phosphate transmembrane transporter activity
B37_RS10950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B37_RS10955	COG0768	penicillin binding
B37_RS10960	COG0477	Major facilitator Superfamily
B37_RS10965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B37_RS10970	COG2839	Protein conserved in bacteria
B37_RS10975	COG5521	maltodextrose utilization protein MalA
B37_RS10980	COG1388	LysM domain
B37_RS10985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B37_RS10990	COG4709	membrane
B37_RS10995	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B37_RS11000	COG0735	belongs to the Fur family
B37_RS11005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B37_RS11010	COG1121	(ABC) transporter
B37_RS11015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS11025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B37_RS11030	COG0513	Belongs to the DEAD box helicase family
B37_RS11040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B37_RS11045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B37_RS11050	COG2384	SAM-dependent methyltransferase
B37_RS11105	COG5444	nuclease activity
B37_RS11120	COG2010	Cytochrome c
B37_RS11125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B37_RS11130	COG0358	DNA primase activity
B37_RS11135	COG1671	Belongs to the UPF0178 family
B37_RS11140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B37_RS11145	COG0517	IMP dehydrogenase activity
B37_RS11150	COG0751	glycine-tRNA ligase activity
B37_RS11155	COG0752	glycyl-tRNA synthetase alpha subunit
B37_RS11160	COG1381	Involved in DNA repair and RecF pathway recombination
B37_RS11170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B37_RS11175	COG0295	cytidine deaminase activity
B37_RS11180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B37_RS11185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B37_RS11190	COG1480	7TM receptor with intracellular HD hydrolase
B37_RS11195	COG1702	phosphate starvation-inducible protein PhoH
B37_RS11200	COG0561	phosphatase activity
B37_RS11215	COG4864	UPF0365 protein
B37_RS11220	COG1030	water channel activity
B37_RS11225	COG1610	YqeY-like protein
B37_RS11230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B37_RS11235	COG1283	sodium-dependent phosphate transmembrane transporter activity
B37_RS11240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B37_RS11245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B37_RS11250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B37_RS11255	COG2264	protein methyltransferase activity
B37_RS11260	COG0484	heat shock protein binding
B37_RS11265	COG0443	Heat shock 70 kDa protein
B37_RS11270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B37_RS11275	COG1420	regulation of RNA biosynthetic process
B37_RS11280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B37_RS11285	COG0481	GTPase activity
B37_RS11295	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS11300	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B37_RS11305	COG0268	Binds directly to 16S ribosomal RNA
B37_RS11310	COG1466	dna polymerase III delta subunit
B37_RS11320	COG2333	competence protein COMEC
B37_RS11320	COG0658	competence protein
B37_RS11325	COG2131	deaminase
B37_RS11330	COG1596	polysaccharide export
B37_RS11330	COG1555	photosystem II stabilization
B37_RS11335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_RS11340	COG2226	methyltransferase
B37_RS11345	COG0799	negative regulation of ribosome biogenesis
B37_RS11350	COG1713	HD superfamily hydrolase involved in NAD metabolism
B37_RS11355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B37_RS11360	COG1534	Rna-binding protein
B37_RS11365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B37_RS11370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B37_RS11375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B37_RS11385	COG2755	lipolytic protein G-D-S-L family
B37_RS11390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_RS11395	COG5609	conserved protein (DUF2294)
B37_RS11400	COG3383	formate dehydrogenase (NAD+) activity
B37_RS11405	COG2427	Protein of unknown function (DUF1641)
B37_RS11440	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS11485	COG1136	(ABC) transporter
B37_RS11490	COG0577	efflux transmembrane transporter activity
B37_RS11575	COG2197	response regulator
B37_RS11580	COG4585	Histidine kinase
B37_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS11590	COG0730	response to heat
B37_RS11595	COG0425	Belongs to the sulfur carrier protein TusA family
B37_RS11600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_RS11600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS11605	COG0425	Belongs to the sulfur carrier protein TusA family
B37_RS11605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_RS11610	COG2210	Belongs to the sulfur carrier protein TusA family
B37_RS11615	COG1937	Protein conserved in bacteria
B37_RS11655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B37_RS11660	COG0113	porphobilinogen synthase activity
B37_RS11665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B37_RS11670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B37_RS11675	COG1733	regulation of RNA biosynthetic process
B37_RS11680	COG3239	Fatty acid desaturase
B37_RS11685	COG4585	Histidine kinase
B37_RS11690	COG2197	response regulator
B37_RS11695	COG0492	ferredoxin-NADP+ reductase activity
B37_RS11700	COG0747	negative chemotaxis
B37_RS11705	COG0601	transmembrane transport
B37_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_RS11715	COG0444	Belongs to the ABC transporter superfamily
B37_RS11720	COG4608	Belongs to the ABC transporter superfamily
B37_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS11755	COG2124	cytochrome p450
B37_RS11760	COG0730	response to heat
B37_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS11780	COG1621	beta-fructofuranosidase activity
B37_RS11785	COG3716	PTS system mannose fructose sorbose family IID component
B37_RS11790	COG3715	PTS system
B37_RS11795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS11800	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS11825	COG2169	Transcriptional regulator
B37_RS11830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B37_RS11835	COG0656	L-ascorbic acid biosynthetic process
B37_RS11840	COG2814	Major facilitator Superfamily
B37_RS11845	COG1733	regulation of RNA biosynthetic process
B37_RS11850	COG3340	Belongs to the peptidase S51 family
B37_RS11855	COG1587	Uroporphyrinogen-III synthase
B37_RS11865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS11870	COG0583	DNA-binding transcription factor activity
B37_RS11875	COG2814	Major facilitator Superfamily
B37_RS11885	COG2124	cytochrome p450
B37_RS11885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B37_RS11890	COG1309	transcriptional regulator
B37_RS11895	COG1404	Belongs to the peptidase S8 family
B37_RS11900	COG2226	methyltransferase
B37_RS11925	COG0626	cystathionine gamma-synthase activity
B37_RS11930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_RS11935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B37_RS11940	COG2226	methyltransferase
B37_RS11955	COG0768	penicillin binding
B37_RS11960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B37_RS11965	COG0572	uridine kinase
B37_RS11970	COG0826	peptidase U32
B37_RS11975	COG0826	peptidase U32
B37_RS11980	COG4122	O-methyltransferase activity
B37_RS11985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B37_RS11990	COG3906	Belongs to the UPF0473 family
B37_RS11995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B37_RS12000	COG4472	Bacterial protein of unknown function (DUF965)
B37_RS12005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B37_RS12010	COG0628	permease
B37_RS12025	COG3881	PFAM PRC-barrel domain
B37_RS12030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B37_RS12035	COG0457	Tetratricopeptide repeat
B37_RS12040	COG0482	sulfurtransferase activity
B37_RS12045	COG1104	cysteine desulfurase activity
B37_RS12050	COG1959	2 iron, 2 sulfur cluster binding
B37_RS12055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B37_RS12060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B37_RS12070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B37_RS12075	COG0124	histidyl-tRNA synthetase
B37_RS12080	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS12080	COG4991	sh3 domain protein
B37_RS12080	COG3103	Sh3 type 3 domain protein
B37_RS12085	COG1490	D-aminoacyl-tRNA deacylase activity
B37_RS12090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B37_RS12095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_RS12100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B37_RS12100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B37_RS12105	COG5416	Lipopolysaccharide assembly protein A domain
B37_RS12110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B37_RS12110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B37_RS12120	COG2244	polysaccharide biosynthetic process
B37_RS12125	COG2323	membrane
B37_RS12135	COG1862	Preprotein translocase
B37_RS12140	COG0343	queuine tRNA-ribosyltransferase activity
B37_RS12145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B37_RS12155	COG2255	four-way junction helicase activity
B37_RS12160	COG0632	four-way junction helicase activity
B37_RS12170	COG2112	serine threonine protein kinase
B37_RS12180	COG2318	DinB family
B37_RS12185	COG4195	phage-related replication protein
B37_RS12200	COG0217	transcriptional regulatory protein
B37_RS12215	COG1388	LysM domain
B37_RS12220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B37_RS12225	COG0157	Belongs to the NadC ModD family
B37_RS12230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B37_RS12235	COG1104	cysteine desulfurase activity
B37_RS12240	COG1827	regulation of RNA biosynthetic process
B37_RS12245	COG0077	Prephenate dehydratase
B37_RS12250	COG4492	Belongs to the UPF0735 family
B37_RS12255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B37_RS12260	COG3290	protein histidine kinase activity
B37_RS12265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B37_RS12270	COG2868	ribosomal protein
B37_RS12275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B37_RS12280	COG1994	Peptidase M50
B37_RS12285	COG0739	heme binding
B37_RS12290	COG3832	glyoxalase III activity
B37_RS12295	COG0640	Transcriptional regulator
B37_RS12300	COG2894	cell division
B37_RS12305	COG0850	regulation of cytokinetic process
B37_RS12310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B37_RS12320	COG1077	Cell shape determining protein MreB Mrl
B37_RS12325	COG2003	Belongs to the UPF0758 family
B37_RS12340	COG0457	Tetratricopeptide repeat
B37_RS12345	COG5444	nuclease activity
B37_RS12390	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_RS12455	COG4626	Terminase
B37_RS12455	COG1802	Transcriptional regulator
B37_RS12575	COG2003	Belongs to the UPF0758 family
B37_RS12580	COG0424	maF-like protein
B37_RS12590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B37_RS12595	COG0285	dihydrofolate synthase activity
B37_RS12600	COG0525	valine-tRNA ligase activity
B37_RS12610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B37_RS12615	COG1388	LysM domain
B37_RS12620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B37_RS12625	COG0113	porphobilinogen synthase activity
B37_RS12630	COG1587	Uroporphyrinogen-III synthase
B37_RS12635	COG0181	hydroxymethylbilane synthase activity
B37_RS12640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B37_RS12645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B37_RS12655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B37_RS12660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B37_RS12665	COG1067	ATP-dependent peptidase activity
B37_RS12665	COG0470	DNA polymerase III
B37_RS12670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B37_RS12675	COG0544	peptidyl-prolyl cis-trans isomerase activity
B37_RS12680	COG0457	Tetratricopeptide repeat
B37_RS12680	COG1477	protein flavinylation
B37_RS12685	COG0066	3-isopropylmalate dehydratase activity
B37_RS12690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B37_RS12695	COG0473	3-isopropylmalate dehydrogenase activity
B37_RS12700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B37_RS12705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B37_RS12710	COG0440	acetolactate synthase activity
B37_RS12715	COG0028	Belongs to the TPP enzyme family
B37_RS12720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_RS12730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B37_RS12750	COG5518	Phage portal protein
B37_RS12755	COG1783	phage Terminase large subunit
B37_RS12790	COG5444	nuclease activity
B37_RS12795	COG0457	Tetratricopeptide repeat
B37_RS12815	COG0622	Phosphoesterase
B37_RS12820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B37_RS12825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B37_RS12830	COG5401	PFAM Sporulation and spore germination
B37_RS12835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B37_RS12840	COG1846	Transcriptional regulator
B37_RS12845	COG2197	response regulator
B37_RS12850	COG4221	oxidoreductase activity
B37_RS12855	COG0824	Thioesterase
B37_RS12860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B37_RS12865	COG1053	succinate dehydrogenase
B37_RS12870	COG2009	succinate dehydrogenase
B37_RS12875	COG1719	4-vinyl reductase, 4VR
B37_RS12880	COG0527	aspartate kinase activity
B37_RS12885	COG0322	excinuclease ABC activity
B37_RS12890	COG3118	belongs to the thioredoxin family
B37_RS12895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B37_RS12900	COG2086	electron transfer activity
B37_RS12905	COG1024	Enoyl-CoA hydratase
B37_RS12910	COG1309	transcriptional regulator
B37_RS12915	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS12920	COG3766	membrane
B37_RS12925	COG1193	negative regulation of DNA recombination
B37_RS12930	COG1796	DNA polymerase
B37_RS12930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B37_RS12935	COG1286	toxin biosynthetic process
B37_RS12940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B37_RS12945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B37_RS12975	COG1137	ATPase activity
B37_RS12990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_RS12990	COG0072	phenylalanine-tRNA ligase activity
B37_RS12995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B37_RS13000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B37_RS13010	COG1966	Carbon starvation protein
B37_RS13025	COG0395	ABC-type sugar transport system, permease component
B37_RS13030	COG1175	transmembrane transport
B37_RS13035	COG1653	transport
B37_RS13040	COG0371	Dehydrogenase
B37_RS13045	COG0235	Class ii aldolase
B37_RS13050	COG1069	ribulokinase activity
B37_RS13055	COG2160	L-arabinose isomerase activity
B37_RS13060	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_RS13065	COG1363	Peptidase, m42
B37_RS13075	COG3326	Membrane
B37_RS13080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B37_RS13085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B37_RS13090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B37_RS13095	COG1346	cytolysis
B37_RS13105	COG3540	Alkaline phosphatase
B37_RS13110	COG3279	Response regulator of the LytR AlgR family
B37_RS13115	COG3275	phosphorelay sensor kinase activity
B37_RS13125	COG1011	Hydrolase
B37_RS13130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B37_RS13140	COG0398	Pfam SNARE associated Golgi protein
B37_RS13145	COG1484	DNA-dependent DNA replication
B37_RS13150	COG3611	Membrane attachment protein
B37_RS13155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B37_RS13170	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B37_RS13175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B37_RS13180	COG3866	Pectate lyase
B37_RS13185	COG0237	dephospho-CoA kinase activity
B37_RS13190	COG1971	Probably functions as a manganese efflux pump
B37_RS13195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B37_RS13200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_RS13200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_RS13205	COG5002	protein histidine kinase activity
B37_RS13210	COG0745	RESPONSE REGULATOR receiver
B37_RS13215	COG0039	L-malate dehydrogenase activity
B37_RS13220	COG0538	isocitrate dehydrogenase activity
B37_RS13225	COG0372	Belongs to the citrate synthase family
B37_RS13230	COG2707	UPF0756 membrane protein
B37_RS13235	COG0628	permease
B37_RS13240	COG3030	protein affecting phage T7 exclusion by the F plasmid
B37_RS13250	COG0205	6-phosphofructokinase activity
B37_RS13255	COG0825	malonyl-CoA metabolic process
B37_RS13260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B37_RS13265	COG0281	malic enzyme
B37_RS13270	COG0587	DNA-directed DNA polymerase activity
B37_RS13290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B37_RS13300	COG4109	DRTGG domain
B37_RS13305	COG1695	Transcriptional regulator
B37_RS13310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B37_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS13320	COG0165	Argininosuccinate lyase
B37_RS13325	COG0137	argininosuccinate synthase activity
B37_RS13330	COG0521	Mo-molybdopterin cofactor biosynthetic process
B37_RS13335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B37_RS13340	COG0827	DNA restriction-modification system
B37_RS13345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B37_RS13350	COG3874	Sporulation protein YtfJ
B37_RS13360	COG1714	RDD family
B37_RS13365	COG0616	signal peptide processing
B37_RS13370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B37_RS13375	COG1566	PFAM secretion protein HlyD family protein
B37_RS13380	COG0477	Major facilitator Superfamily
B37_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_RS13400	COG0301	tRNA thio-modification
B37_RS13405	COG1104	cysteine desulfurase activity
B37_RS13410	COG1114	Component of the transport system for branched-chain amino acids
B37_RS13420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B37_RS13425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B37_RS13430	COG1309	transcriptional regulator
B37_RS13435	COG1956	GAF domain-containing protein
B37_RS13440	COG2203	Gaf domain
B37_RS13440	COG2199	diguanylate cyclase activity
B37_RS13450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B37_RS13465	COG3152	Membrane
B37_RS13470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B37_RS13475	COG1522	sequence-specific DNA binding
B37_RS13480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B37_RS13485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_RS13490	COG0454	-acetyltransferase
B37_RS13495	COG0517	IMP dehydrogenase activity
B37_RS13500	COG0123	including yeast histone deacetylase and acetoin utilization protein
B37_RS13505	COG1360	Flagellar Motor Protein
B37_RS13510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B37_RS13515	COG1609	Transcriptional regulator
B37_RS13520	COG1605	Chorismate mutase
B37_RS13520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B37_RS13530	COG3118	belongs to the thioredoxin family
B37_RS13535	COG4980	gas vesicle protein
B37_RS13540	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B37_RS13545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B37_RS13550	COG1674	ftsk spoiiie
B37_RS13555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_RS13560	COG4848	Belongs to the UPF0354 family
B37_RS13565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS13575	COG1363	Peptidase, m42
B37_RS13580	COG5584	Small secreted protein
B37_RS13585	COG0281	malic enzyme
B37_RS13590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_RS13595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B37_RS13605	COG0510	thiamine kinase activity
B37_RS13615	COG1597	lipid kinase activity
B37_RS13625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B37_RS13630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_RS13645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_RS13650	COG2252	PERMEase
B37_RS13655	COG1349	DNA-binding transcription factor activity
B37_RS13660	COG1187	pseudouridine synthase activity
B37_RS13665	COG2244	polysaccharide biosynthetic process
B37_RS13670	COG2081	HI0933 family
B37_RS13675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B37_RS13685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_RS13690	COG0457	Tetratricopeptide repeat
B37_RS13700	COG5578	integral membrane protein
B37_RS13705	COG0673	inositol 2-dehydrogenase activity
B37_RS13710	COG1653	transport
B37_RS13715	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B37_RS13720	COG4209	transmembrane transport
B37_RS13725	COG2207	Transcriptional regulator
B37_RS13735	COG1653	transport
B37_RS13740	COG0395	ABC-type sugar transport system, permease component
B37_RS13745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_RS13750	COG1073	alpha beta
B37_RS13760	COG0583	DNA-binding transcription factor activity
B37_RS13765	COG0346	lactoylglutathione lyase activity
B37_RS13770	COG0495	leucyl-tRNA aminoacylation
B37_RS13780	COG2814	Major facilitator Superfamily
B37_RS13790	COG2433	Pfam Transposase IS66
B37_RS13795	COG0577	efflux transmembrane transporter activity
B37_RS13800	COG1136	(ABC) transporter
B37_RS13810	COG1131	(ABC) transporter
B37_RS13815	COG1725	Transcriptional regulator
B37_RS13825	COG1242	4 iron, 4 sulfur cluster binding
B37_RS13830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B37_RS13835	COG1301	dicarboxylic acid transport
B37_RS13845	COG2267	carboxylic ester hydrolase activity
B37_RS13850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B37_RS13855	COG0671	phosphoesterase, PA-phosphatase related
B37_RS13860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_RS13860	COG0438	transferase activity, transferring glycosyl groups
B37_RS13865	COG0367	asparagine synthase
B37_RS13870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B37_RS13875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B37_RS13890	COG1506	peptidase
B37_RS13895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B37_RS13900	COG1116	anion transmembrane transporter activity
B37_RS13905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B37_RS13910	COG0494	nUDIX hydrolase
B37_RS13920	COG4824	toxin secretion phage lysis holin
B37_RS13925	COG0783	Belongs to the Dps family
B37_RS13940	COG1854	S-ribosylhomocysteine lyase activity
B37_RS13945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B37_RS13950	COG0288	reversible hydration of carbon dioxide
B37_RS13955	COG0523	cobalamin synthesis protein
B37_RS13960	COG0803	Belongs to the bacterial solute-binding protein 9 family
B37_RS13965	COG0254	rRNA binding
B37_RS13970	COG1271	oxidase subunit
B37_RS13975	COG1294	oxidase, subunit
B37_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
B37_RS13995	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS14000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B37_RS14005	COG0596	Alpha beta hydrolase
B37_RS14010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B37_RS14015	COG1169	isochorismate synthase
B37_RS14020	COG1575	Belongs to the MenA family. Type 1 subfamily
B37_RS14025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_RS14035	COG0297	glycogen (starch) synthase activity
B37_RS14040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B37_RS14045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B37_RS14050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B37_RS14175	COG1609	Transcriptional regulator
B37_RS14180	COG3859	Proton-coupled thiamine transporter YuaJ
B37_RS14185	COG3764	Sortase (surface protein transpeptidase)
B37_RS14200	COG0457	Tetratricopeptide repeat
B37_RS14205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B37_RS14210	COG0569	domain protein
B37_RS14215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_RS14225	COG2318	DinB family
B37_RS14235	COG1454	alcohol dehydrogenase
B37_RS14240	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS14245	COG1510	regulation of RNA biosynthetic process
B37_RS14255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B37_RS14260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B37_RS14265	COG2140	Oxalate decarboxylase
B37_RS14330	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B37_RS14340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_RS14345	COG0726	polysaccharide deacetylase
B37_RS14350	COG1408	metallophosphoesterase
B37_RS14355	COG1968	undecaprenyl-diphosphatase activity
B37_RS14360	COG0628	permease
B37_RS14365	COG0673	inositol 2-dehydrogenase activity
B37_RS14370	COG0693	protein deglycase activity
B37_RS14375	COG0840	transmembrane signaling receptor activity
B37_RS14380	COG0840	transmembrane signaling receptor activity
B37_RS14395	COG2070	2-Nitropropane dioxygenase
B37_RS14400	COG0432	Pfam Uncharacterised protein family UPF0047
B37_RS14405	COG0366	Alpha amylase catalytic
B37_RS14420	COG5297	Belongs to the glycosyl hydrolase family 6
B37_RS14425	COG1253	flavin adenine dinucleotide binding
B37_RS14430	COG2738	Putative neutral zinc metallopeptidase
B37_RS14445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B37_RS14460	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B37_RS14505	COG5444	nuclease activity
B37_RS14545	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_RS14550	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_RS14560	COG3953	SLT domain
B37_RS14560	COG5280	Phage tail tape measure protein TP901
B37_RS14620	COG4626	Terminase
B37_RS14620	COG1802	Transcriptional regulator
B37_RS14740	COG0166	Belongs to the GPI family
B37_RS14745	COG1979	alcohol dehydrogenase
B37_RS14750	COG2155	Conserved Protein
B37_RS14755	COG1098	S1 RNA binding domain
B37_RS14760	COG0436	Aminotransferase
B37_RS14765	COG1522	sequence-specific DNA binding
B37_RS14770	COG2267	carboxylic ester hydrolase activity
B37_RS14785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B37_RS14800	COG5018	Exonuclease
B37_RS14805	COG2814	Major facilitator Superfamily
B37_RS14810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_RS14815	COG3011	Protein conserved in bacteria
B37_RS14825	COG3290	protein histidine kinase activity
B37_RS14830	COG4565	transcriptional regulatory protein
B37_RS14840	COG1183	phosphatidylcholine synthase activity
B37_RS14845	COG0586	Pfam SNARE associated Golgi protein
B37_RS14850	COG0688	phosphatidylethanolamine metabolic process
B37_RS14855	COG3493	citrate carrier protein
B37_RS14865	COG2111	Na H antiporter
B37_RS14865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B37_RS14870	COG2111	Na H antiporter
B37_RS14875	COG1006	Multisubunit Na H antiporter MnhC subunit
B37_RS14880	COG0651	ATP synthesis coupled electron transport
B37_RS14885	COG1863	multisubunit Na H antiporter MnhE subunit
B37_RS14890	COG2212	antiporter activity
B37_RS14895	COG1320	monovalent cation:proton antiporter activity
B37_RS14900	COG2050	protein possibly involved in aromatic compounds catabolism
B37_RS14905	COG2197	response regulator
B37_RS14910	COG4585	Histidine kinase
B37_RS14940	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B37_RS14945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B37_RS14950	COG1335	isochorismatase
B37_RS14955	COG5506	Protein of unknown function (DUF1694)
B37_RS14970	COG0628	permease
B37_RS14975	COG1959	2 iron, 2 sulfur cluster binding
B37_RS14990	COG1418	mRNA catabolic process
B37_RS14995	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS15005	COG1511	domain protein
B37_RS15010	COG0433	COG0433 Predicted ATPase
B37_RS15010	COG1674	ftsk spoiiie
B37_RS15015	COG4499	WXG100 protein secretion system (Wss), protein YukC
B37_RS15020	COG5417	Belongs to the EsaB family
B37_RS15025	COG4842	Belongs to the WXG100 family
B37_RS15030	COG1115	amino acid carrier protein
B37_RS15035	COG2508	Transcriptional regulator
B37_RS15035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B37_RS15040	COG0686	Belongs to the AlaDH PNT family
B37_RS15050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B37_RS15055	COG1268	BioY protein
B37_RS15060	COG2056	Na+-H+ antiporter family
B37_RS15065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B37_RS15070	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B37_RS15075	COG3584	3D domain protein
B37_RS15085	COG1252	NADH dehydrogenase
B37_RS15090	COG0492	ferredoxin-NADP+ reductase activity
B37_RS15105	COG0456	acetyltransferase
B37_RS15110	COG0316	Belongs to the HesB IscA family
B37_RS15115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B37_RS15120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_RS15125	COG4844	belongs to the
B37_RS15130	COG1252	NADH dehydrogenase
B37_RS15135	COG5646	InterPro IPR014922
B37_RS15145	COG0457	Tetratricopeptide repeat
B37_RS15150	COG3479	Phenolic acid decarboxylase
B37_RS15160	COG4837	Protein of unknown function (DUF1462)
B37_RS15165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B37_RS15170	COG4946	Tricorn protease homolog
B37_RS15170	COG1506	peptidase
B37_RS15170	COG0823	Involved in the tonB-independent uptake of proteins
B37_RS15175	COG0083	homoserine kinase activity
B37_RS15180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B37_RS15185	COG0460	homoserine dehydrogenase
B37_RS15195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B37_RS15200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B37_RS15205	COG0647	UMP catabolic process
B37_RS15210	COG2445	Protein of unknown function DUF86
B37_RS15215	COG4470	Protein conserved in bacteria
B37_RS15230	COG0739	heme binding
B37_RS15240	COG0733	neurotransmitter:sodium symporter activity
B37_RS15250	COG3377	Domain of unknown function (DUF1805)
B37_RS15255	COG0737	Belongs to the 5'-nucleotidase family
B37_RS15260	COG0730	response to heat
B37_RS15265	COG1801	Protein of unknown function DUF72
B37_RS15275	COG3226	Transcriptional regulator
B37_RS15285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B37_RS15290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_RS15295	COG2508	Transcriptional regulator
B37_RS15300	COG2814	Major facilitator Superfamily
B37_RS15305	COG1288	antiporter activity
B37_RS15310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_RS15315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_RS15320	COG2356	endonuclease I
B37_RS15330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B37_RS15345	COG0457	Tetratricopeptide repeat
B37_RS15350	COG0719	Fe-S assembly protein
B37_RS15355	COG0822	iron-sulfur transferase activity
B37_RS15360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B37_RS15365	COG0719	Fe-S assembly protein
B37_RS15370	COG0396	ATPase activity
B37_RS15380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B37_RS15385	COG1464	Belongs to the NlpA lipoprotein family
B37_RS15390	COG2011	ABC-type metal ion transport system permease component
B37_RS15395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B37_RS15405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS15410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B37_RS15420	COG0509	glycine decarboxylation via glycine cleavage system
B37_RS15425	COG1393	Belongs to the ArsC family
B37_RS15430	COG1960	acyl-CoA dehydrogenase activity
B37_RS15435	COG0183	Belongs to the thiolase family
B37_RS15440	COG1250	3-hydroxyacyl-CoA dehydrogenase
B37_RS15440	COG1024	Enoyl-CoA hydratase
B37_RS15455	COG5577	PFAM Coat F domain
B37_RS15470	COG1120	ATPase activity
B37_RS15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS15480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS15500	COG1686	Belongs to the peptidase S11 family
B37_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS15510	COG0783	Belongs to the Dps family
B37_RS15515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_RS15520	COG0745	RESPONSE REGULATOR receiver
B37_RS15525	COG2770	Histidine kinase
B37_RS15525	COG2205	protein histidine kinase activity
B37_RS15530	COG1309	transcriptional regulator
B37_RS15535	COG0114	fumarate hydratase activity
B37_RS15545	COG0697	spore germination
B37_RS15550	COG0814	amino acid
B37_RS15565	COG2197	response regulator
B37_RS15570	COG4585	Histidine kinase
B37_RS15575	COG4758	membrane
B37_RS15585	COG1842	Phage shock protein A
B37_RS15590	COG4758	membrane
B37_RS15595	COG4677	pectinesterase activity
B37_RS15600	COG2096	Adenosyltransferase
B37_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS15615	COG1454	alcohol dehydrogenase
B37_RS15620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_RS15625	COG1120	ATPase activity
B37_RS15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS15640	COG1802	Transcriptional regulator
B37_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS15650	COG2258	MOSC domain
B37_RS15655	COG0583	DNA-binding transcription factor activity
B37_RS15665	COG2721	sulfolactate sulfo-lyase activity
B37_RS15670	COG0246	Mannitol dehydrogenase
B37_RS15675	COG1609	Transcriptional regulator
B37_RS15680	COG2211	Major facilitator Superfamily
B37_RS15685	COG1904	glucuronate isomerase
B37_RS15690	COG2205	protein histidine kinase activity
B37_RS15695	COG0745	RESPONSE REGULATOR receiver
B37_RS15700	COG1120	ATPase activity
B37_RS15705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS15710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS15715	COG0531	amino acid
B37_RS15725	COG1988	membrane-bound metal-dependent
B37_RS15730	COG1368	sulfuric ester hydrolase activity
B37_RS15735	COG2814	Major facilitator Superfamily
B37_RS15740	COG0656	L-ascorbic acid biosynthetic process
B37_RS15745	COG1940	carbohydrate kinase activity
B37_RS15750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B37_RS15760	COG3973	AAA domain
B37_RS15765	COG2860	membrane
B37_RS15770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B37_RS15770	COG0456	acetyltransferase
B37_RS15775	COG0456	acetyltransferase
B37_RS15780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B37_RS15785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B37_RS15790	COG2217	Heavy metal translocating P-type atpase
B37_RS15795	COG1653	transport
B37_RS15800	COG1175	transmembrane transport
B37_RS15805	COG0395	ABC-type sugar transport system, permease component
B37_RS15810	COG1501	Belongs to the glycosyl hydrolase 31 family
B37_RS15815	COG1472	Belongs to the glycosyl hydrolase 3 family
B37_RS15820	COG1121	(ABC) transporter
B37_RS15825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B37_RS15830	COG0803	Belongs to the bacterial solute-binding protein 9 family
B37_RS15845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B37_RS15845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B37_RS15850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS15850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS15850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_RS15865	COG2217	Heavy metal translocating P-type atpase
B37_RS15870	COG2608	mercury ion transmembrane transporter activity
B37_RS15875	COG1937	Protein conserved in bacteria
B37_RS15880	COG0693	protein deglycase activity
B37_RS15885	COG1349	DNA-binding transcription factor activity
B37_RS15890	COG1070	Carbohydrate kinase
B37_RS15895	COG4952	isomerase
B37_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS15905	COG3347	Dehydrogenase
B37_RS15915	COG2814	Major facilitator Superfamily
B37_RS15925	COG2124	cytochrome p450
B37_RS15935	COG1846	Transcriptional regulator
B37_RS15945	COG0673	inositol 2-dehydrogenase activity
B37_RS15950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B37_RS15955	COG1054	Belongs to the UPF0176 family
B37_RS15965	COG1191	sigma factor activity
B37_RS15975	COG2140	Oxalate decarboxylase
B37_RS16005	COG5444	nuclease activity
B37_RS16025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B37_RS16030	COG0557	exoribonuclease II activity
B37_RS16035	COG1647	Serine aminopeptidase, S33
B37_RS16040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B37_RS16045	COG2002	toxin-antitoxin pair type II binding
B37_RS16050	COG1476	TRANSCRIPTIONal
B37_RS16055	COG1396	sequence-specific DNA binding
B37_RS16060	COG1396	sequence-specific DNA binding
B37_RS16065	COG1174	glycine betaine transport
B37_RS16070	COG1732	Glycine betaine
B37_RS16075	COG1174	glycine betaine transport
B37_RS16080	COG1125	glycine betaine transport
B37_RS16080	COG0517	IMP dehydrogenase activity
B37_RS16085	COG1510	regulation of RNA biosynthetic process
B37_RS16090	COG2095	MarC family integral membrane protein
B37_RS16095	COG3064	Membrane
B37_RS16105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS16115	COG0693	protein deglycase activity
B37_RS16120	COG0148	phosphopyruvate hydratase activity
B37_RS16125	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B37_RS16130	COG0149	triose-phosphate isomerase activity
B37_RS16135	COG0126	phosphoglycerate kinase activity
B37_RS16140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B37_RS16145	COG2390	Transcriptional regulator
B37_RS16150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_RS16155	COG1113	amino acid transport
B37_RS16165	COG1131	(ABC) transporter
B37_RS16175	COG1556	Lactate utilization protein
B37_RS16180	COG1139	Iron-sulfur cluster binding protein
B37_RS16185	COG0247	lactate metabolic process
B37_RS16190	COG2186	Transcriptional regulator
B37_RS16195	COG1620	l-lactate permease
B37_RS16200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B37_RS16210	COG5039	Polysaccharide pyruvyl transferase
B37_RS16215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_RS16220	COG0110	maltose O-acetyltransferase activity
B37_RS16225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B37_RS16230	COG2244	polysaccharide biosynthetic process
B37_RS16235	COG1216	Glycosyl transferase, family 2
B37_RS16240	COG5039	Polysaccharide pyruvyl transferase
B37_RS16245	COG1216	Glycosyl transferase, family 2
B37_RS16255	COG0438	transferase activity, transferring glycosyl groups
B37_RS16260	COG1215	transferase activity, transferring glycosyl groups
B37_RS16265	COG0438	transferase activity, transferring glycosyl groups
B37_RS16270	COG1086	Polysaccharide biosynthesis protein
B37_RS16275	COG0489	protein tyrosine kinase activity
B37_RS16280	COG3944	biosynthesis protein
B37_RS16285	COG1396	sequence-specific DNA binding
B37_RS16290	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_RS16295	COG2271	Major facilitator Superfamily
B37_RS16305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B37_RS16320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_RS16330	COG1733	regulation of RNA biosynthetic process
B37_RS16335	COG1902	pentaerythritol trinitrate reductase activity
B37_RS16340	COG1621	beta-fructofuranosidase activity
B37_RS16345	COG1621	beta-fructofuranosidase activity
B37_RS16360	COG0740	serine-type endopeptidase activity
B37_RS16365	COG1611	Belongs to the LOG family
B37_RS16370	COG1694	Mazg nucleotide pyrophosphohydrolase
B37_RS16375	COG1078	dGTPase activity
B37_RS16380	COG0659	secondary active sulfate transmembrane transporter activity
B37_RS16385	COG0288	reversible hydration of carbon dioxide
B37_RS16390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_RS16395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B37_RS16400	COG0640	Transcriptional regulator
B37_RS16410	COG2732	(Barnase) inhibitor
B37_RS16415	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B37_RS16420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS16425	COG1481	regulation of sporulation
B37_RS16430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B37_RS16435	COG1660	Displays ATPase and GTPase activities
B37_RS16440	COG1051	belongs to the nudix hydrolase family
B37_RS16450	COG0492	ferredoxin-NADP+ reductase activity
B37_RS16455	COG0457	Tetratricopeptide repeat
B37_RS16460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_RS16465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B37_RS16465	COG0140	phosphoribosyl-ATP diphosphatase activity
B37_RS16470	COG0107	imidazoleglycerol-phosphate synthase activity
B37_RS16475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B37_RS16480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B37_RS16485	COG0131	Imidazoleglycerol-phosphate dehydratase
B37_RS16490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B37_RS16495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B37_RS16500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B37_RS16505	COG4990	cell redox homeostasis
B37_RS16510	COG5297	Belongs to the glycosyl hydrolase family 6
B37_RS16515	COG0110	maltose O-acetyltransferase activity
B37_RS16520	COG0546	phosphoglycolate phosphatase activity
B37_RS16525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B37_RS16530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B37_RS16535	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B37_RS16540	COG1846	Transcriptional regulator
B37_RS16545	COG2814	Major facilitator Superfamily
B37_RS16550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B37_RS16555	COG1950	PFAM Membrane protein of
B37_RS16560	COG1983	PspC domain protein
B37_RS16565	COG3595	metallopeptidase activity
B37_RS16590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B37_RS16595	COG0556	nucleotide-excision repair
B37_RS16600	COG4897	Protein conserved in bacteria
B37_RS16610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_RS16620	COG0793	Belongs to the peptidase S41A family
B37_RS16620	COG3409	Peptidoglycan-binding domain 1 protein
B37_RS16625	COG0473	3-isopropylmalate dehydrogenase activity
B37_RS16630	COG0791	NLP P60 protein
B37_RS16630	COG3883	PFAM NLP P60 protein
B37_RS16635	COG2177	Part of the ABC transporter FtsEX involved in
B37_RS16640	COG2884	Cell division ATP-binding protein ftsE
B37_RS16650	COG2010	Cytochrome c
B37_RS16655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS16660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B37_RS16665	COG0653	protein targeting
B37_RS16670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B37_RS16685	COG1516	flagellar protein fliS
B37_RS16690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B37_RS16695	COG1334	flagellar protein FlaG
B37_RS16700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B37_RS16705	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B37_RS16710	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B37_RS16720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B37_RS16725	COG1256	bacterial-type flagellum assembly
B37_RS16725	COG4786	Flagellar basal body rod
B37_RS16730	COG3418	PFAM FlgN family protein
B37_RS16735	COG2747	anti-sigma28 factor FlgM
B37_RS16745	COG1040	competence protein
B37_RS16755	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B37_RS16760	COG1307	EDD domain protein, DegV family
B37_RS16765	COG2197	response regulator
B37_RS16770	COG4585	Histidine kinase
B37_RS16775	COG1739	Uncharacterized protein family UPF0029
B37_RS16780	COG1316	TRANSCRIPTIONal
B37_RS16790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B37_RS16795	COG0438	transferase activity, transferring glycosyl groups
B37_RS16800	COG1215	transferase activity, transferring glycosyl groups
B37_RS16805	COG3206	protein involved in exopolysaccharide biosynthesis
B37_RS16810	COG3307	-O-antigen
B37_RS16815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_RS16820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B37_RS16825	COG0438	transferase activity, transferring glycosyl groups
B37_RS16825	COG0297	glycogen (starch) synthase activity
B37_RS16830	COG2244	polysaccharide biosynthetic process
B37_RS16840	COG2247	cell wall binding repeat
B37_RS16840	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS16845	COG2247	cell wall binding repeat
B37_RS16845	COG2385	sporulation resulting in formation of a cellular spore
B37_RS16855	COG1316	TRANSCRIPTIONal
B37_RS16865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B37_RS16870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B37_RS16875	COG1134	teichoic acid transport
B37_RS16880	COG1682	transport, permease protein
B37_RS16895	COG0463	Glycosyl transferase, family 2
B37_RS16895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_RS16900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_RS16905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B37_RS16910	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B37_RS16915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_RS16920	COG4193	domain, Protein
B37_RS16925	COG1482	cell wall glycoprotein biosynthetic process
B37_RS16945	COG0800	Aldolase
B37_RS16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_RS16955	COG1609	Transcriptional regulator
B37_RS16960	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B37_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS16970	COG1063	alcohol dehydrogenase
B37_RS16975	COG2814	Major facilitator Superfamily
B37_RS16980	COG1316	TRANSCRIPTIONal
B37_RS16985	COG0561	phosphatase activity
B37_RS16990	COG0791	NLP P60 protein
B37_RS16995	COG2843	Capsule synthesis protein
B37_RS17005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B37_RS17010	COG1609	Transcriptional regulator
B37_RS17015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_RS17020	COG1869	D-ribose catabolic process
B37_RS17025	COG1129	ABC transporter
B37_RS17030	COG1172	Belongs to the binding-protein-dependent transport system permease family
B37_RS17035	COG1879	ABC-type sugar transport system periplasmic component
B37_RS17045	COG3527	Alpha-acetolactate decarboxylase
B37_RS17050	COG0028	Belongs to the TPP enzyme family
B37_RS17055	COG0583	DNA-binding transcription factor activity
B37_RS17065	COG0405	Gamma-glutamyltransferase
B37_RS17070	COG1522	sequence-specific DNA binding
B37_RS17075	COG2059	Chromate
B37_RS17080	COG2059	Chromate
B37_RS17085	COG4464	protein tyrosine phosphatase activity
B37_RS17090	COG3944	biosynthesis protein
B37_RS17095	COG4715	Zinc finger, swim domain protein
B37_RS17100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B37_RS17105	COG0561	phosphatase activity
B37_RS17110	COG1349	DNA-binding transcription factor activity
B37_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS17130	COG3732	PTS system glucitol sorbitol-specific
B37_RS17150	COG0629	single-stranded DNA binding
B37_RS17165	COG1970	mechanosensitive ion channel activity
B37_RS17170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B37_RS17175	COG4786	Flagellar basal body rod
B37_RS17180	COG4786	Flagellar basal body rod
B37_RS17185	COG1077	Cell shape determining protein MreB Mrl
B37_RS17190	COG1609	Transcriptional regulator
B37_RS17200	COG1846	Transcriptional regulator
B37_RS17205	COG2814	Major facilitator Superfamily
B37_RS17210	COG0671	phosphoesterase, PA-phosphatase related
B37_RS17215	COG1227	inorganic diphosphatase activity
B37_RS17220	COG3546	catalase activity
B37_RS17225	COG3361	conserved protein (COG2071)
B37_RS17235	COG0598	Magnesium transport protein CorA
B37_RS17240	COG1253	flavin adenine dinucleotide binding
B37_RS17245	COG0004	ammonium transporteR
B37_RS17250	COG0347	Belongs to the P(II) protein family
B37_RS17255	COG0740	serine-type endopeptidase activity
B37_RS17265	COG0739	heme binding
B37_RS17270	COG1247	-acetyltransferase
B37_RS17280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_RS17290	COG0477	Major facilitator Superfamily
B37_RS17295	COG3251	PFAM MbtH domain protein
B37_RS17300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_RS17305	COG3433	isochorismatase activity
B37_RS17305	COG1535	isochorismatase
B37_RS17310	COG1021	2,3-dihydroxybenzoate-AMP ligase
B37_RS17315	COG1169	isochorismate synthase
B37_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS17325	COG2819	hydrolase of the alpha beta superfamily
B37_RS17330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS17335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS17340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS17345	COG2207	Transcriptional regulator
B37_RS17345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS17355	COG2910	NAD(P)H-binding
B37_RS17360	COG1959	2 iron, 2 sulfur cluster binding
B37_RS17365	COG1994	Peptidase M50
B37_RS17370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B37_RS17375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B37_RS17380	COG2223	nitrite transmembrane transporter activity
B37_RS17385	COG3383	formate dehydrogenase (NAD+) activity
B37_RS17390	COG2304	oxidoreductase activity
B37_RS17395	COG2304	oxidoreductase activity
B37_RS17400	COG2385	sporulation resulting in formation of a cellular spore
B37_RS17405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B37_RS17415	COG4836	Membrane
B37_RS17420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B37_RS17425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B37_RS17430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B37_RS17435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B37_RS17440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B37_RS17445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B37_RS17450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B37_RS17470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B37_RS17475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B37_RS17480	COG4475	Protein of unknown function (DUF436)
B37_RS17485	COG0698	ribose 5-phosphate isomerase
B37_RS17490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_RS17495	COG1971	Probably functions as a manganese efflux pump
B37_RS17500	COG0009	L-threonylcarbamoyladenylate synthase
B37_RS17505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B37_RS17515	COG0738	Major facilitator superfamily
B37_RS17520	COG0673	inositol 2-dehydrogenase activity
B37_RS17525	COG0561	phosphatase activity
B37_RS17530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_RS17535	COG1609	Transcriptional regulator
B37_RS17540	COG2890	protein-(glutamine-N5) methyltransferase activity
B37_RS17545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B37_RS17550	COG0346	lactoylglutathione lyase activity
B37_RS17555	COG0789	Transcriptional regulator
B37_RS17560	COG0679	Auxin Efflux Carrier
B37_RS17565	COG0281	malic enzyme
B37_RS17570	COG1435	thymidine kinase activity
B37_RS17575	COG0254	rRNA binding
B37_RS17580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B37_RS17585	COG1494	fructose-1,6-bisphosphatase
B37_RS17590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B37_RS17595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B37_RS17600	COG0191	fructose-bisphosphate aldolase activity
B37_RS17605	COG2204	response regulator
B37_RS17610	COG4821	SIS domain
B37_RS17620	COG0504	CTP synthase activity
B37_RS17625	COG3343	RNA polymerase activity
B37_RS17630	COG1960	acyl-CoA dehydrogenase activity
B37_RS17635	COG1960	acyl-CoA dehydrogenase activity
B37_RS17640	COG1250	3-hydroxyacyl-CoA dehydrogenase
B37_RS17645	COG0183	Belongs to the thiolase family
B37_RS17650	COG0247	lactate metabolic process
B37_RS17650	COG2181	nitrate reductase activity
B37_RS17655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_RS17665	COG0018	arginyl-trna synthetase
B37_RS17670	COG4506	Protein conserved in bacteria
B37_RS17675	COG0010	Belongs to the arginase family
B37_RS17680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B37_RS17695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_RS17705	COG1994	Peptidase M50
B37_RS17710	COG1942	4-Oxalocrotonate Tautomerase
B37_RS17720	COG3465	dGTPase activity
B37_RS17725	COG1078	dGTPase activity
B37_RS17730	COG4844	belongs to the
B37_RS17755	COG2814	Major facilitator Superfamily
B37_RS17780	COG1414	Transcriptional regulator
B37_RS17790	COG0280	phosphate acetyltransferase
B37_RS17795	COG3253	May function as heme-dependent peroxidase
B37_RS17810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_RS17830	COG1131	(ABC) transporter
B37_RS17845	COG2363	Small membrane protein
B37_RS17850	COG2233	PERMEase
B37_RS17860	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS17865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B37_RS17870	COG1216	Glycosyl transferase, family 2
B37_RS17875	COG0351	phosphomethylpyrimidine kinase
B37_RS17885	COG1621	beta-fructofuranosidase activity
B37_RS17890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS17890	COG1263	PTS System
B37_RS17895	COG3711	transcriptional antiterminator
B37_RS17905	COG1404	Belongs to the peptidase S8 family
B37_RS17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_RS17920	COG0778	Nitroreductase
B37_RS17925	COG1473	amidohydrolase
B37_RS17930	COG0772	Belongs to the SEDS family
B37_RS17935	COG0772	Belongs to the SEDS family
B37_RS17940	COG3314	Sporulation integral membrane protein YlbJ
B37_RS17960	COG0456	acetyltransferase
B37_RS17995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B37_RS18005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B37_RS18010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B37_RS18015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_RS18035	COG3162	membrane
B37_RS18040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS18045	COG1070	Carbohydrate kinase
B37_RS18050	COG2115	Belongs to the xylose isomerase family
B37_RS18060	COG0352	thiamine-phosphate diphosphorylase activity
B37_RS18065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B37_RS18070	COG0583	DNA-binding transcription factor activity
B37_RS18085	COG1380	Effector of murein hydrolase LrgA
B37_RS18090	COG1346	cytolysis
B37_RS18100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS18105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B37_RS18110	COG0346	lactoylglutathione lyase activity
B37_RS18115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_RS18120	COG1442	glycosyl transferase family 8
B37_RS18125	COG4585	Histidine kinase
B37_RS18130	COG2197	response regulator
B37_RS18135	COG2409	Drug exporters of the RND superfamily
B37_RS18140	COG5522	Integral membrane protein (intg_mem_TP0381)
B37_RS18145	COG2271	Major facilitator Superfamily
B37_RS18150	COG4948	Mandelate Racemase Muconate Lactonizing
B37_RS18155	COG0800	Aldolase
B37_RS18160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_RS18170	COG2234	aminopeptidase activity
B37_RS18175	COG0477	Major facilitator Superfamily
B37_RS18185	COG2357	RelA SpoT domain protein
B37_RS18200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_RS18205	COG1696	Membrane protein involved in D-alanine export
B37_RS18210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B37_RS18215	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B37_RS18220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_RS18225	COG2814	Major facilitator Superfamily
B37_RS18230	COG1486	melibiose metabolic process
B37_RS18235	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_RS18240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS18245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS18250	COG3711	transcriptional antiterminator
B37_RS18250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS18255	COG2094	Belongs to the DNA glycosylase MPG family
B37_RS18265	COG0372	Belongs to the citrate synthase family
B37_RS18270	COG2079	MmgE PrpD family protein
B37_RS18275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B37_RS18290	COG1132	(ABC) transporter
B37_RS18295	COG2755	lipolytic protein G-D-S-L family
B37_RS18310	COG2814	Major facilitator Superfamily
B37_RS18315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_RS18320	COG1131	(ABC) transporter
B37_RS18340	COG1595	DNA-templated transcription, initiation
B37_RS18345	COG2814	Major facilitator Superfamily
B37_RS18350	COG0753	catalase activity
B37_RS18355	COG0753	catalase activity
B37_RS18360	COG0735	belongs to the Fur family
B37_RS18365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B37_RS18370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_RS18375	COG1131	(ABC) transporter
B37_RS18390	COG1131	(ABC) transporter
B37_RS18445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B37_RS18450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B37_RS18455	COG4988	ABC transporter
B37_RS18460	COG1294	oxidase, subunit
B37_RS18465	COG1271	oxidase subunit
B37_RS18475	COG2116	formate transmembrane transporter activity
B37_RS18485	COG0281	malic enzyme
B37_RS18490	COG1757	Na H antiporter
B37_RS18495	COG1027	Aspartate ammonia-lyase
B37_RS18500	COG0252	asparaginase activity
B37_RS18505	COG1396	sequence-specific DNA binding
B37_RS18510	COG2706	6-phosphogluconolactonase activity
B37_RS18515	COG0745	RESPONSE REGULATOR receiver
B37_RS18520	COG2205	protein histidine kinase activity
B37_RS18530	COG1136	(ABC) transporter
B37_RS18535	COG0577	efflux transmembrane transporter activity
B37_RS18540	COG5294	Protein conserved in bacteria
B37_RS18550	COG0726	polysaccharide deacetylase
B37_RS18555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_RS18560	COG1215	transferase activity, transferring glycosyl groups
B37_RS18570	COG3493	citrate carrier protein
B37_RS18575	COG0584	glycerophosphoryl diester phosphodiesterase
B37_RS18590	COG1368	sulfuric ester hydrolase activity
B37_RS18600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS18615	COG2235	arginine
B37_RS18620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B37_RS18630	COG0549	Belongs to the carbamate kinase family
B37_RS18640	COG2723	6-phospho-beta-galactosidase activity
B37_RS18645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS18655	COG1595	DNA-templated transcription, initiation
B37_RS18680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B37_RS18685	COG2195	Cleaves the N-terminal amino acid of tripeptides
B37_RS18695	COG1621	beta-fructofuranosidase activity
B37_RS18700	COG2223	nitrite transmembrane transporter activity
B37_RS18710	COG1609	Transcriptional regulator
B37_RS18725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B37_RS18730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B37_RS18735	COG0463	Glycosyl transferase, family 2
B37_RS18740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_RS18765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_RS18780	COG2723	6-phospho-beta-galactosidase activity
B37_RS18785	COG1263	PTS System
B37_RS18785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS18785	COG2190	(PTS) system
B37_RS18790	COG3711	transcriptional antiterminator
B37_RS18795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B37_RS18800	COG1122	ATPase activity
B37_RS18805	COG4721	ABC-type cobalt transport system, permease component
B37_RS18810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B37_RS18815	COG2224	Isocitrate lyase
B37_RS18820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B37_RS18830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B37_RS18835	COG0577	efflux transmembrane transporter activity
B37_RS18840	COG1136	(ABC) transporter
B37_RS18845	COG2205	protein histidine kinase activity
B37_RS18850	COG0745	RESPONSE REGULATOR receiver
B37_RS18855	COG2723	6-phospho-beta-galactosidase activity
B37_RS18860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS18860	COG1263	PTS System
B37_RS18860	COG2190	(PTS) system
B37_RS18870	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B37_RS18885	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_RS18915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B37_RS18920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_RS18925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B37_RS18930	COG2390	Transcriptional regulator
B37_RS18945	COG3706	GGDEF domain
B37_RS18955	COG1215	transferase activity, transferring glycosyl groups
B37_RS18965	COG3977	Valine--pyruvate aminotransferase
B37_RS18980	COG1181	Belongs to the D-alanine--D-alanine ligase family
B37_RS18990	COG0191	fructose-bisphosphate aldolase activity
B37_RS18995	COG1082	Xylose isomerase domain protein TIM barrel
B37_RS19000	COG1082	Xylose isomerase domain protein TIM barrel
B37_RS19005	COG0673	inositol 2-dehydrogenase activity
B37_RS19010	COG2814	Major facilitator Superfamily
B37_RS19015	COG1082	Xylose isomerase domain protein TIM barrel
B37_RS19020	COG3962	Belongs to the TPP enzyme family
B37_RS19025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_RS19030	COG3718	enzyme involved in inositol metabolism
B37_RS19035	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS19040	COG1349	DNA-binding transcription factor activity
B37_RS19045	COG0667	Aldo Keto reductase
B37_RS19050	COG0584	glycerophosphoryl diester phosphodiesterase
B37_RS19055	COG2271	Major facilitator Superfamily
B37_RS19060	COG0326	Molecular chaperone. Has ATPase activity
B37_RS19065	COG0488	(ABC) transporter
B37_RS19070	COG0561	phosphatase activity
B37_RS19090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_RS19120	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B37_RS19125	COG0577	efflux transmembrane transporter activity
B37_RS19130	COG1136	(ABC) transporter
B37_RS19135	COG2205	protein histidine kinase activity
B37_RS19140	COG0745	RESPONSE REGULATOR receiver
B37_RS19150	COG0840	transmembrane signaling receptor activity
B37_RS19150	COG5278	phosphoserine phosphatase activity
B37_RS19155	COG1115	amino acid carrier protein
B37_RS19160	COG0686	Belongs to the AlaDH PNT family
B37_RS19165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B37_RS19170	COG1874	Beta-galactosidase
B37_RS19175	COG3833	ABC-type maltose transport systems, permease component
B37_RS19180	COG1175	transmembrane transport
B37_RS19185	COG2182	Extracellular solute-binding protein
B37_RS19190	COG1609	Transcriptional regulator
B37_RS19200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_RS19205	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B37_RS19210	COG1940	carbohydrate kinase activity
B37_RS19235	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS19235	COG1454	alcohol dehydrogenase
B37_RS19240	COG0450	alkyl hydroperoxide reductase
B37_RS19245	COG3634	alkyl hydroperoxide reductase activity
B37_RS19270	COG1131	(ABC) transporter
B37_RS19275	COG0842	Transport permease protein
B37_RS19285	COG2197	response regulator
B37_RS19310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B37_RS19325	COG0456	acetyltransferase
B37_RS19340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_RS19345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B37_RS19350	COG4853	Protein conserved in bacteria
B37_RS19355	COG4863	YycH protein
B37_RS19360	COG5002	protein histidine kinase activity
B37_RS19365	COG0745	RESPONSE REGULATOR receiver
B37_RS19390	COG1051	belongs to the nudix hydrolase family
B37_RS19395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B37_RS19405	COG0305	Participates in initiation and elongation during chromosome replication
B37_RS19420	COG3093	addiction module antidote protein HigA
B37_RS19425	COG2807	transmembrane transport
B37_RS19430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B37_RS19435	COG0363	glucosamine-6-phosphate deaminase activity
B37_RS19440	COG2188	Transcriptional regulator
B37_RS19445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B37_RS19450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS19450	COG1263	PTS System
B37_RS19455	COG0359	binds to the 23S rRNA
B37_RS19460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B37_RS19465	COG4241	membrane
B37_RS19470	COG5577	PFAM Coat F domain
B37_RS19475	COG0589	response to stress
B37_RS19480	COG0659	secondary active sulfate transmembrane transporter activity
B37_RS19485	COG2271	Major facilitator Superfamily
B37_RS19490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B37_RS19495	COG0629	single-stranded DNA binding
B37_RS19500	COG0360	Binds together with S18 to 16S ribosomal RNA
B37_RS19505	COG0012	GTP binding
B37_RS19515	COG4481	Protein conserved in bacteria
B37_RS19520	COG3949	Membrane
B37_RS19530	COG1475	DNA binding
B37_RS19535	COG1192	Involved in chromosome partitioning
B37_RS19540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B37_RS19550	COG1475	DNA binding
B37_RS19555	COG0357	Ribosomal RNA small subunit methyltransferase G
B37_RS19560	COG0445	tRNA wobble uridine modification
B37_RS19565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B37_RS19570	COG1847	R3H domain protein
B37_RS19575	COG0706	membrane insertase activity
B37_RS19580	COG0594	ribonuclease P activity
B37_RS19590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B37_RS19595	COG0592	DNA-directed DNA polymerase activity
B37_RS19600	COG2501	S4 domain
B37_RS19605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B37_RS19615	COG0187	DNA topoisomerase II activity
B37_RS19620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B37_RS19655	COG0516	GMP reductase activity
B37_RS19655	COG0517	IMP dehydrogenase activity
B37_RS19660	COG1686	Belongs to the peptidase S11 family
B37_RS19665	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B37_RS19670	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B37_RS19675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B37_RS19680	COG1929	Belongs to the glycerate kinase type-1 family
B37_RS19690	COG3835	regulator
B37_RS19705	COG1428	Deoxynucleoside kinase
B37_RS19710	COG1428	Deoxynucleoside kinase
B37_RS19715	COG3858	chitin binding
B37_RS19715	COG1388	LysM domain
B37_RS19720	COG1335	isochorismatase
B37_RS19725	COG0590	tRNA wobble adenosine to inosine editing
B37_RS19735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B37_RS19740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B37_RS19745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B37_RS19790	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B37_RS19795	COG3853	Toxic anion resistance protein (TelA)
B37_RS19800	COG1982	Orn Lys Arg decarboxylase major
B37_RS19805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B37_RS19810	COG3870	Protein conserved in bacteria
B37_RS19815	COG1728	Protein conserved in bacteria
B37_RS19820	COG0470	DNA polymerase III
B37_RS19825	COG1774	PSP1 C-terminal conserved region
B37_RS19830	COG4467	Involved in initiation control of chromosome replication
B37_RS19835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B37_RS19840	COG2827	Endonuclease containing a URI domain
B37_RS19845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B37_RS19850	COG2002	toxin-antitoxin pair type II binding
B37_RS19855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_RS19855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_RS19860	COG0084	hydrolase, TatD family'
B37_RS19865	COG3584	3D domain protein
B37_RS19865	COG3583	domain protein
B37_RS19870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B37_RS19875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B37_RS19885	COG4466	Protein conserved in bacteria
B37_RS19895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B37_RS19900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_RS19905	COG0251	oxidation-reduction process
B37_RS19910	COG2088	sporulation resulting in formation of a cellular spore
B37_RS19915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B37_RS19920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B37_RS19925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B37_RS19930	COG0193	aminoacyl-tRNA hydrolase activity
B37_RS19940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B37_RS19945	COG2002	toxin-antitoxin pair type II binding
B37_RS19950	COG2244	polysaccharide biosynthetic process
B37_RS19955	COG3956	TIGRFAM MazG family protein
B37_RS19960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B37_RS19975	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B37_RS19980	COG1098	S1 RNA binding domain
B37_RS19995	COG2208	phosphoserine phosphatase activity
B37_RS20000	COG2304	oxidoreductase activity
B37_RS20005	COG0515	serine threonine protein kinase
B37_RS20010	COG0037	tRNA processing
B37_RS20015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B37_RS20020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B37_RS20025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B37_RS20030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B37_RS20035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B37_RS20040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_RS20050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B37_RS20055	COG0512	Glutamine amidotransferase of anthranilate synthase
B37_RS20060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_RS20065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B37_RS20070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B37_RS20075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B37_RS20080	COG1396	sequence-specific DNA binding
B37_RS20085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B37_RS20090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B37_RS20170	COG4463	regulation of RNA biosynthetic process
B37_RS20175	COG3880	PFAM UvrB UvrC protein
B37_RS20180	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B37_RS20185	COG0542	response to heat
B37_RS20190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B37_RS20195	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B37_RS20200	COG4956	integral membrane protein (PIN domain superfamily)
B37_RS20205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B37_RS20210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B37_RS20215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B37_RS20220	COG1045	serine acetyltransferase
B37_RS20225	COG0215	cysteine-tRNA ligase activity
B37_RS20230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B37_RS20235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B37_RS20240	COG3688	RNA-binding protein containing a PIN domain
B37_RS20250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B37_RS20260	COG0250	Participates in transcription elongation, termination and antitermination
B37_RS20265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B37_RS20270	COG0081	regulation of translation
B37_RS20275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B37_RS20280	COG0222	ribosome binding
B37_RS20285	COG2813	Specifically methylates the guanine in position
B37_RS20290	COG0085	RNA polymerase activity
B37_RS20295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B37_RS20300	COG1358	cellular component organization or biogenesis
B37_RS20305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B37_RS20310	COG0049	tRNA binding
B37_RS20315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B37_RS20320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B37_RS20330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B37_RS20335	COG0088	Forms part of the polypeptide exit tunnel
B37_RS20340	COG0089	rRNA binding
B37_RS20345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B37_RS20350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B37_RS20355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B37_RS20360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B37_RS20365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B37_RS20370	COG0255	Belongs to the universal ribosomal protein uL29 family
B37_RS20375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B37_RS20380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B37_RS20385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B37_RS20390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B37_RS20395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_RS20400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B37_RS20405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B37_RS20410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B37_RS20415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B37_RS20420	COG1841	ribosomal large subunit assembly
B37_RS20425	COG0200	Binds to the 23S rRNA
B37_RS20430	COG0201	protein transport
B37_RS20435	COG0563	adenylate kinase activity
B37_RS20440	COG0024	Methionine aminopeptidase
B37_RS20445	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B37_RS20450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B37_RS20455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B37_RS20460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B37_RS20465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B37_RS20470	COG0202	RNA polymerase activity
B37_RS20475	COG0203	ribosomal protein L17
B37_RS20480	COG1122	ATPase activity
B37_RS20485	COG1122	ATPase activity
B37_RS20490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B37_RS20495	COG0101	tRNA pseudouridine synthase activity
B37_RS20500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B37_RS20505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B37_RS20510	COG2318	DinB family
B37_RS20520	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_RS20525	COG0489	protein tyrosine kinase activity
B37_RS20535	COG2194	sulfuric ester hydrolase activity
B37_RS20540	COG0726	polysaccharide deacetylase
B37_RS20570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_RS20580	COG0385	Bile acid
B37_RS20595	COG3876	Protein conserved in bacteria
B37_RS20600	COG1472	Belongs to the glycosyl hydrolase 3 family
B37_RS20605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_RS20610	COG1263	PTS System
B37_RS20610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS20615	COG1737	Transcriptional regulator
B37_RS20620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B37_RS20625	COG1683	Conserved Protein
B37_RS20660	COG1595	DNA-templated transcription, initiation
B37_RS20665	COG5662	AntiSigma factor
B37_RS20670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B37_RS20675	COG4856	YbbR-like protein
B37_RS20680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B37_RS20685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B37_RS20700	COG1131	(ABC) transporter
B37_RS20705	COG1725	Transcriptional regulator
B37_RS20710	COG0640	Transcriptional regulator
B37_RS20715	COG2814	Major facilitator Superfamily
B37_RS20725	COG1132	(ABC) transporter
B37_RS20730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B37_RS20755	COG1011	Hydrolase
B37_RS20760	COG1113	amino acid transport
B37_RS20765	COG2851	Citrate transporter
B37_RS20770	COG3181	Tripartite tricarboxylate transporter family receptor
B37_RS20775	COG4565	transcriptional regulatory protein
B37_RS20780	COG3290	protein histidine kinase activity
B37_RS20795	COG2211	Major facilitator Superfamily
B37_RS20815	COG1331	Highly conserved protein containing a thioredoxin domain
B37_RS20820	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B37_RS20825	COG1331	Highly conserved protein containing a thioredoxin domain
B37_RS20835	COG0477	Major facilitator Superfamily
B37_RS20855	COG1283	sodium-dependent phosphate transmembrane transporter activity
B37_RS20860	COG4682	membrane
B37_RS20885	COG0697	spore germination
B37_RS20890	COG2207	Transcriptional regulator
B37_RS20890	COG1917	Cupin 2, conserved barrel domain protein
B37_RS20910	COG0371	Dehydrogenase
B37_RS20915	COG0840	transmembrane signaling receptor activity
B37_RS20920	COG4213	ABC transporter substrate-binding protein
B37_RS20935	COG4257	antibiotic catabolic process
B37_RS20945	COG0833	amino acid
B37_RS20950	COG2040	homocysteine
B37_RS20960	COG2190	(PTS) system
B37_RS20960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_RS20960	COG1263	PTS System
B37_RS20965	COG0789	Transcriptional regulator
B37_RS20970	COG2323	membrane
B37_RS20975	COG4451	ribulose bisphosphate carboxylase, small
B37_RS20975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B37_RS20985	COG2205	protein histidine kinase activity
B37_RS20990	COG1115	amino acid carrier protein
B37_RS20995	COG2066	Belongs to the glutaminase family
B37_RS21000	COG4191	Histidine kinase
B37_RS21005	COG0784	Response regulator, receiver
B37_RS21030	COG3540	Alkaline phosphatase
B37_RS21035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B37_RS21040	COG0805	protein transport
B37_RS21045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_RS21050	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS21055	COG2271	Major facilitator Superfamily
B37_RS21060	COG4948	Mandelate Racemase Muconate Lactonizing
B37_RS21065	COG2186	Transcriptional regulator
B37_RS21070	COG2721	sulfolactate sulfo-lyase activity
B37_RS21075	COG0745	RESPONSE REGULATOR receiver
B37_RS21080	COG2205	protein histidine kinase activity
B37_RS21085	COG1131	(ABC) transporter
B37_RS21110	COG3173	Aminoglycoside phosphotransferase
B37_RS21115	COG1846	Transcriptional regulator
B37_RS21120	COG0318	PFAM AMP-dependent synthetase and ligase
B37_RS21140	COG0789	Transcriptional regulator
B37_RS21165	COG0697	spore germination
B37_RS21170	COG1714	RDD family
B37_RS21175	COG1405	negative regulation of cell septum assembly
B37_RS21175	COG3012	SEC-C Motif Domain Protein
B37_RS21180	COG1131	(ABC) transporter
B37_RS21205	COG0583	DNA-binding transcription factor activity
B37_RS21210	COG1942	4-Oxalocrotonate Tautomerase
B37_RS21215	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS21230	COG1288	antiporter activity
B37_RS21240	COG0456	acetyltransferase
B37_RS21250	COG1164	Oligoendopeptidase f
B37_RS21255	COG2261	transglycosylase associated protein
B37_RS21265	COG0247	lactate metabolic process
B37_RS21270	COG0277	FAD linked oxidase domain protein
B37_RS21275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS21280	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_RS21285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_RS21290	COG1486	melibiose metabolic process
B37_RS21295	COG2188	Transcriptional regulator
B37_RS21300	COG3394	polysaccharide catabolic process
B37_RS21315	COG3591	Belongs to the peptidase S1B family
B37_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS21330	COG1595	DNA-templated transcription, initiation
B37_RS21340	COG3773	Cell wall hydrolase
B37_RS21345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_RS21350	COG3883	PFAM NLP P60 protein
B37_RS21350	COG0791	NLP P60 protein
B37_RS21360	COG1131	(ABC) transporter
B37_RS21365	COG1309	transcriptional regulator
B37_RS21385	COG2310	stress, protein
B37_RS21390	COG2310	stress, protein
B37_RS21395	COG2310	stress, protein
B37_RS21400	COG0861	Integral membrane protein TerC family
B37_RS21420	COG3853	Toxic anion resistance protein (TelA)
B37_RS21425	COG0785	Cytochrome C biogenesis protein
B37_RS21435	COG0789	Transcriptional regulator
B37_RS21440	COG2223	nitrite transmembrane transporter activity
B37_RS21445	COG0039	L-malate dehydrogenase activity
B37_RS21450	COG1620	l-lactate permease
B37_RS21455	COG1280	lysine exporter protein (LysE YggA)
B37_RS21460	COG1113	amino acid transport
B37_RS21465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B37_RS21470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B37_RS21475	COG3541	Predicted nucleotidyltransferase
B37_RS21480	COG0506	proline dehydrogenase activity
B37_RS21485	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS21490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_RS21495	COG2508	Transcriptional regulator
B37_RS21500	COG3689	TIGRFAM TIGR03943 family protein
B37_RS21505	COG0701	Predicted permease
B37_RS21510	COG3458	cephalosporin-C deacetylase activity
B37_RS21530	COG0765	amino acid transport
B37_RS21535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_RS21540	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_RS21550	COG2723	6-phospho-beta-galactosidase activity
B37_RS21560	COG3209	COG3209 Rhs family protein
B37_RS21565	COG3266	domain, Protein
B37_RS21565	COG0515	serine threonine protein kinase
B37_RS21575	COG5444	nuclease activity
B37_RS21600	COG1176	ABC-type spermidine putrescine transport system, permease component I
B37_RS21610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_RS21615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_RS21620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_RS21625	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B37_RS21630	COG0697	spore germination
B37_RS21635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_RS21645	COG2819	hydrolase of the alpha beta superfamily
B37_RS21655	COG2364	Membrane
B37_RS21665	COG1131	(ABC) transporter
B37_RS21690	COG1126	abc transporter atp-binding protein
B37_RS21695	COG0765	amino acid transport
B37_RS21700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_RS21705	COG3829	transcription factor binding
B37_RS21710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B37_RS21715	COG0833	amino acid
B37_RS21720	COG0010	Belongs to the arginase family
B37_RS21725	COG0583	DNA-binding transcription factor activity
B37_RS21730	COG0163	prenyltransferase activity
B37_RS21735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B37_RS21785	COG5444	nuclease activity
B37_RS21805	COG2972	Histidine kinase
B37_RS21810	COG4753	response regulator
B37_RS21810	COG2207	Transcriptional regulator
B37_RS21815	COG4213	ABC transporter substrate-binding protein
B37_RS21825	COG4214	carbohydrate transport
B37_RS21830	COG2271	Major facilitator Superfamily
B37_RS21835	COG1846	Transcriptional regulator
B37_RS21835	COG0456	acetyltransferase
B37_RS21840	COG1874	Beta-galactosidase
B37_RS21845	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B37_RS21850	COG3104	oligopeptide transport
B37_RS21855	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_RS21865	COG0697	spore germination
B37_RS21875	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B37_RS21880	COG0789	Transcriptional regulator
B37_RS21885	COG1136	(ABC) transporter
B37_RS21890	COG0577	efflux transmembrane transporter activity
B37_RS21895	COG0745	RESPONSE REGULATOR receiver
B37_RS21900	COG5002	protein histidine kinase activity
B37_RS21900	COG3850	Histidine kinase
B37_RS21910	COG0527	aspartate kinase activity
B37_RS21915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_RS21920	COG4605	iron ion homeostasis
B37_RS21925	COG4604	ABC transporter, ATP-binding protein
B37_RS21930	COG4607	ABC-type enterochelin transport system periplasmic component
B37_RS21935	COG2814	Major facilitator Superfamily
B37_RS21940	COG1309	transcriptional regulator
B37_RS21950	COG0778	Nitroreductase
B37_RS21955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B37_RS21960	COG0640	Transcriptional regulator
B37_RS21965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_RS21970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B37_RS21975	COG0531	amino acid
B37_RS21980	COG1012	belongs to the aldehyde dehydrogenase family
B37_RS21985	COG0697	spore germination
B37_RS21995	COG4549	nuclear export factor GLE1
B37_RS22000	COG1276	copper resistance
B37_RS22000	COG2372	response to copper ion
B37_RS22005	COG1349	DNA-binding transcription factor activity
B37_RS22010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_RS22015	COG0243	molybdopterin cofactor binding
B37_RS22020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_RS22025	COG2146	nitrite reductase [NAD(P)H] activity
B37_RS22030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B37_RS22030	COG1587	Uroporphyrinogen-III synthase
B37_RS22035	COG1802	Transcriptional regulator
B37_RS22040	COG0471	metal ion transport
B37_RS22045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B37_RS22050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B37_RS22065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS22080	COG3959	Transketolase, thiamine diphosphate binding domain
B37_RS22085	COG3958	Transketolase
B37_RS22090	COG0561	phosphatase activity
B37_RS22095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B37_RS22100	COG1914	H( )-stimulated, divalent metal cation uptake system
B37_RS22105	COG4336	lyase activity
B37_RS22110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B37_RS22115	COG1984	allophanate hydrolase subunit 2
B37_RS22120	COG1414	Transcriptional regulator
B37_RS22125	COG2755	lipolytic protein G-D-S-L family
B37_RS22130	COG2213	PTS system mannitol-specific
B37_RS22135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_RS22140	COG0246	Mannitol dehydrogenase
B37_RS22145	COG3711	transcriptional antiterminator
B37_RS22150	COG1028	Short-chain dehydrogenase reductase Sdr
B37_RS22155	COG1917	Cupin 2, conserved barrel domain protein
B37_RS22165	COG3871	stress protein (general stress protein 26)
B37_RS22180	COG2814	Major facilitator Superfamily
B37_RS22190	COG1522	sequence-specific DNA binding
B37_RS22195	COG0551	DNA topoisomerase type I activity
B37_RS22195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B37_RS22205	COG0028	Belongs to the TPP enzyme family
B37_RS22210	COG3397	chitin binding
B37_RS22225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_RS22230	COG1914	H( )-stimulated, divalent metal cation uptake system
B37_RS22235	COG2261	transglycosylase associated protein
B37_RS22240	COG1027	Aspartate ammonia-lyase
B37_RS22245	COG1819	glycosyl
B37_RS22250	COG4876	unkown
B37_RS22255	COG2217	Heavy metal translocating P-type atpase
B37_RS22265	COG0662	Cupin 2, conserved barrel domain protein
B37_RS22270	COG3729	General stress protein
B37_RS22275	COG0628	permease
B37_RS22280	COG1301	dicarboxylic acid transport
B37_RS22285	COG1131	(ABC) transporter
B37_RS22290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_RS22300	COG1960	acyl-CoA dehydrogenase activity
B37_RS22315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_RS22320	COG1181	Belongs to the D-alanine--D-alanine ligase family
B37_RS22325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B37_RS22335	COG0513	Belongs to the DEAD box helicase family
B37_RS22340	COG3402	PFAM membrane-flanked domain
B37_RS22345	COG3428	Bacterial PH domain
B37_RS22350	COG0705	Rhomboid family
B37_RS22355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B37_RS22360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B37_RS22365	COG0864	Transcriptional regulator
B37_RS22370	COG2337	Toxic component of a toxin-antitoxin (TA) module
B37_RS22375	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_RS22380	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_RS22385	COG2172	sigma factor antagonist activity
B37_RS22390	COG2208	phosphoserine phosphatase activity
B37_RS22400	COG2172	sigma factor antagonist activity
B37_RS22405	COG1191	sigma factor activity
B37_RS22410	COG2208	phosphoserine phosphatase activity
B37_RS22415	COG2183	response to ionizing radiation
B37_RS22420	COG1309	transcriptional regulator
B37_RS22425	COG2409	Drug exporters of the RND superfamily
B37_RS22425	COG1033	growth of symbiont in host cell
B37_RS22430	COG3091	SprT-like family
B37_RS22475	COG1476	TRANSCRIPTIONal
B37_RS22480	COG3239	Fatty acid desaturase
B37_RS22485	COG1278	Cold shock
B37_RS22490	COG1063	alcohol dehydrogenase
B37_RS22500	COG2364	Membrane
B37_RS22505	COG1846	Transcriptional regulator
B37_RS22510	COG0456	acetyltransferase
B37_RS22515	COG2808	Putative FMN-binding domain
B37_RS22525	COG1733	regulation of RNA biosynthetic process
B37_RS22530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_RS22540	COG0583	DNA-binding transcription factor activity
B37_RS22555	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B37_RS22560	COG1113	amino acid transport
B37_RS22575	COG1595	DNA-templated transcription, initiation
B37_RS22585	COG2755	lipolytic protein G-D-S-L family
B37_RS22585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B37_RS22590	COG2814	Major facilitator Superfamily
B37_RS22595	COG0745	RESPONSE REGULATOR receiver
B37_RS22595	COG2972	Histidine kinase
B37_RS22600	COG3279	Response regulator of the LytR AlgR family
B37_RS22610	COG3764	Sortase (surface protein transpeptidase)
B37_RS22615	COG2814	Major facilitator Superfamily
B37_RS22655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B37_RS22660	COG0802	atpase or kinase
B37_RS22665	COG1214	PFAM Peptidase M22, glycoprotease
B37_RS22670	COG0456	acetyltransferase
B37_RS22675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B37_RS22680	COG0488	(ABC) transporter
B37_RS22685	COG0315	cyclic pyranopterin monophosphate synthase activity
B37_RS22690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B37_RS22695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B37_RS22700	COG0805	protein transport
B37_RS22710	COG1266	CAAX protease self-immunity
B37_RS22715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B37_RS22720	COG0459	protein refolding
B37_RS22725	COG4974	Belongs to the 'phage' integrase family
B37_RS22730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B37_RS22825	COG0582	viral genome integration into host DNA
B37_RS22865	COG1802	Transcriptional regulator
B37_RS22865	COG4626	Terminase