locus-tag	class	description
S100141_RS00005	COG1653	transport
S100141_RS00010	COG1175	transmembrane transport
S100141_RS00015	COG0395	ABC-type sugar transport system, permease component
S100141_RS00025	COG2188	Transcriptional regulator
S100141_RS00035	COG2356	endonuclease I
S100141_RS00040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100141_RS00045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100141_RS00050	COG2814	Major facilitator Superfamily
S100141_RS00085	COG1801	Protein of unknown function DUF72
S100141_RS00090	COG0730	response to heat
S100141_RS00095	COG0737	Belongs to the 5'-nucleotidase family
S100141_RS00105	COG0739	heme binding
S100141_RS00120	COG4470	Protein conserved in bacteria
S100141_RS00125	COG2445	Protein of unknown function DUF86
S100141_RS00130	COG0647	UMP catabolic process
S100141_RS00135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100141_RS00140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100141_RS00145	COG0460	homoserine dehydrogenase
S100141_RS00150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100141_RS00165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100141_RS00170	COG4837	Protein of unknown function (DUF1462)
S100141_RS00175	COG1252	NADH dehydrogenase
S100141_RS00185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100141_RS00195	COG0316	Belongs to the HesB IscA family
S100141_RS00200	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100141_RS00205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS00225	COG1131	(ABC) transporter
S100141_RS00265	COG3584	3D domain protein
S100141_RS00270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100141_RS00280	COG2056	Na+-H+ antiporter family
S100141_RS00285	COG1268	BioY protein
S100141_RS00290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100141_RS00295	COG2819	hydrolase of the alpha beta superfamily
S100141_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS00305	COG1169	isochorismate synthase
S100141_RS00310	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100141_RS00315	COG3433	isochorismatase activity
S100141_RS00315	COG1535	isochorismatase
S100141_RS00320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS00325	COG3251	PFAM MbtH domain protein
S100141_RS00330	COG5634	Uncharacterized conserved protein (DUF2278)
S100141_RS00335	COG0686	Belongs to the AlaDH PNT family
S100141_RS00340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100141_RS00340	COG2508	Transcriptional regulator
S100141_RS00345	COG4842	Belongs to the WXG100 family
S100141_RS00350	COG5417	Belongs to the EsaB family
S100141_RS00355	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100141_RS00360	COG1674	ftsk spoiiie
S100141_RS00360	COG0433	COG0433 Predicted ATPase
S100141_RS00380	COG1418	mRNA catabolic process
S100141_RS00390	COG0628	permease
S100141_RS00405	COG5506	Protein of unknown function (DUF1694)
S100141_RS00410	COG1335	isochorismatase
S100141_RS00415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100141_RS00420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100141_RS00450	COG4585	Histidine kinase
S100141_RS00455	COG2197	response regulator
S100141_RS00460	COG2050	protein possibly involved in aromatic compounds catabolism
S100141_RS00465	COG1320	monovalent cation:proton antiporter activity
S100141_RS00470	COG2212	antiporter activity
S100141_RS00475	COG1863	multisubunit Na H antiporter MnhE subunit
S100141_RS00480	COG0651	ATP synthesis coupled electron transport
S100141_RS00490	COG2111	Na H antiporter
S100141_RS00495	COG2111	Na H antiporter
S100141_RS00495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100141_RS00505	COG1079	Belongs to the binding-protein-dependent transport system permease family
S100141_RS00510	COG4603	Belongs to the binding-protein-dependent transport system permease family
S100141_RS00515	COG3845	ABC transporter
S100141_RS00520	COG1744	ABC transporter substrate-binding protein PnrA-like
S100141_RS00525	COG4565	transcriptional regulatory protein
S100141_RS00530	COG3290	protein histidine kinase activity
S100141_RS00540	COG3011	Protein conserved in bacteria
S100141_RS00545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100141_RS00550	COG2814	Major facilitator Superfamily
S100141_RS00555	COG5018	Exonuclease
S100141_RS00570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100141_RS00580	COG2267	carboxylic ester hydrolase activity
S100141_RS00585	COG1522	sequence-specific DNA binding
S100141_RS00590	COG0436	Aminotransferase
S100141_RS00595	COG1098	S1 RNA binding domain
S100141_RS00600	COG2155	Conserved Protein
S100141_RS00605	COG1979	alcohol dehydrogenase
S100141_RS00615	COG1335	isochorismatase
S100141_RS00645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100141_RS00665	COG1253	flavin adenine dinucleotide binding
S100141_RS00670	COG0366	Alpha amylase catalytic
S100141_RS00675	COG0432	Pfam Uncharacterised protein family UPF0047
S100141_RS00680	COG2070	2-Nitropropane dioxygenase
S100141_RS00700	COG0840	transmembrane signaling receptor activity
S100141_RS00710	COG0840	transmembrane signaling receptor activity
S100141_RS00715	COG0693	protein deglycase activity
S100141_RS00720	COG0673	inositol 2-dehydrogenase activity
S100141_RS00725	COG0628	permease
S100141_RS00740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S100141_RS00755	COG5444	nuclease activity
S100141_RS00795	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100141_RS00800	COG0569	domain protein
S100141_RS00810	COG1510	regulation of RNA biosynthetic process
S100141_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS00820	COG1454	alcohol dehydrogenase
S100141_RS00830	COG2318	DinB family
S100141_RS00835	COG1585	Membrane protein implicated in regulation of membrane protease activity
S100141_RS00840	COG2268	Band 7 protein
S100141_RS00845	COG3859	Proton-coupled thiamine transporter YuaJ
S100141_RS00940	COG4974	Belongs to the 'phage' integrase family
S100141_RS01065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100141_RS01065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100141_RS01080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S100141_RS01110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS01120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS01125	COG0756	dUTP diphosphatase activity
S100141_RS01135	COG3584	3D domain protein
S100141_RS01250	COG0740	serine-type endopeptidase activity
S100141_RS01300	COG3953	SLT domain
S100141_RS01300	COG5280	Phage tail tape measure protein TP901
S100141_RS01340	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100141_RS01340	COG3409	Peptidoglycan-binding domain 1 protein
S100141_RS01340	COG1388	LysM domain
S100141_RS01360	COG0438	transferase activity, transferring glycosyl groups
S100141_RS01430	COG5444	nuclease activity
S100141_RS01450	COG0457	Tetratricopeptide repeat
S100141_RS01455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100141_RS01465	COG0710	3-dehydroquinate dehydratase activity
S100141_RS01470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S100141_RS01475	COG1116	anion transmembrane transporter activity
S100141_RS01480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100141_RS01485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100141_RS01490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100141_RS01500	COG1476	TRANSCRIPTIONal
S100141_RS01510	COG1131	(ABC) transporter
S100141_RS01530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100141_RS01540	COG3382	B3 4 domain protein
S100141_RS01545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S100141_RS01555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100141_RS01560	COG0789	Transcriptional regulator
S100141_RS01565	COG1664	Polymer-forming cytoskeletal
S100141_RS01575	COG2766	serine protein kinase
S100141_RS01580	COG2718	Belongs to the UPF0229 family
S100141_RS01595	COG4974	Belongs to the 'phage' integrase family
S100141_RS01665	COG0457	Tetratricopeptide repeat
S100141_RS01675	COG5444	nuclease activity
S100141_RS01695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100141_RS01730	COG4195	phage-related replication protein
S100141_RS01735	COG4195	phage-related replication protein
S100141_RS01740	COG5434	Belongs to the glycosyl hydrolase 28 family
S100141_RS01740	COG3420	alginic acid biosynthetic process
S100141_RS01760	COG2131	deaminase
S100141_RS01765	COG2002	toxin-antitoxin pair type II binding
S100141_RS01910	COG0739	heme binding
S100141_RS01910	COG1196	nuclear chromosome segregation
S100141_RS01910	COG0741	lytic transglycosylase activity
S100141_RS01945	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100141_RS01975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100141_RS02005	COG1132	(ABC) transporter
S100141_RS02035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100141_RS02065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS02070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS02100	COG1566	PFAM secretion protein HlyD family protein
S100141_RS02105	COG2814	Major facilitator Superfamily
S100141_RS02110	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100141_RS02130	COG1131	(ABC) transporter
S100141_RS02135	COG1131	(ABC) transporter
S100141_RS02140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100141_RS02150	COG1278	Cold shock
S100141_RS02155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100141_RS02160	COG2011	ABC-type metal ion transport system permease component
S100141_RS02165	COG1464	Belongs to the NlpA lipoprotein family
S100141_RS02170	COG1823	symporter activity
S100141_RS02195	COG5577	PFAM Coat F domain
S100141_RS02200	COG5002	protein histidine kinase activity
S100141_RS02205	COG4085	toxin activity
S100141_RS02205	COG1525	nuclease
S100141_RS02205	COG0737	Belongs to the 5'-nucleotidase family
S100141_RS02210	COG3764	Sortase (surface protein transpeptidase)
S100141_RS02215	COG0564	pseudouridine synthase activity
S100141_RS02225	COG0517	IMP dehydrogenase activity
S100141_RS02230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100141_RS02235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100141_RS02235	COG3153	acetyltransferase
S100141_RS02240	COG0488	(ABC) transporter
S100141_RS02250	COG2116	formate transmembrane transporter activity
S100141_RS02255	COG0679	Auxin Efflux Carrier
S100141_RS02260	COG0604	alcohol dehydrogenase
S100141_RS02265	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S100141_RS02270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100141_RS02275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100141_RS02280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100141_RS02285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100141_RS02300	COG4585	Histidine kinase
S100141_RS02300	COG2203	Gaf domain
S100141_RS02305	COG2197	response regulator
S100141_RS02310	COG0431	NADPH-dependent FMN reductase
S100141_RS02325	COG1959	2 iron, 2 sulfur cluster binding
S100141_RS02330	COG1017	nitric oxide dioxygenase activity
S100141_RS02330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S100141_RS02335	COG2719	SpoVR family
S100141_RS02340	COG0791	NLP P60 protein
S100141_RS02340	COG1388	LysM domain
S100141_RS02345	COG0583	DNA-binding transcription factor activity
S100141_RS02350	COG0372	Belongs to the citrate synthase family
S100141_RS02355	COG2133	pyrroloquinoline quinone binding
S100141_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS02365	COG0733	neurotransmitter:sodium symporter activity
S100141_RS02375	COG3708	Transcriptional regulator
S100141_RS02375	COG2207	Transcriptional regulator
S100141_RS02380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100141_RS02400	COG1595	DNA-templated transcription, initiation
S100141_RS02405	COG0662	Cupin 2, conserved barrel domain protein
S100141_RS02415	COG0204	Acyl-transferase
S100141_RS02420	COG3152	Membrane
S100141_RS02430	COG1309	transcriptional regulator
S100141_RS02435	COG1253	flavin adenine dinucleotide binding
S100141_RS02440	COG0789	Transcriptional regulator
S100141_RS02445	COG1253	flavin adenine dinucleotide binding
S100141_RS02465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100141_RS02470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100141_RS02475	COG0584	glycerophosphoryl diester phosphodiesterase
S100141_RS02485	COG0668	transmembrane transport
S100141_RS02490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100141_RS02505	COG0726	polysaccharide deacetylase
S100141_RS02515	COG1757	Na H antiporter
S100141_RS02520	COG2017	converts alpha-aldose to the beta-anomer
S100141_RS02545	COG0589	response to stress
S100141_RS02550	COG1132	(ABC) transporter
S100141_RS02555	COG1132	(ABC) transporter
S100141_RS02560	COG0702	epimerase
S100141_RS02575	COG3842	ATPase activity
S100141_RS02580	COG2508	Transcriptional regulator
S100141_RS02590	COG0189	ligase activity
S100141_RS02595	COG0189	ligase activity
S100141_RS02600	COG4399	Belongs to the UPF0754 family
S100141_RS02605	COG3679	Belongs to the UPF0342 family
S100141_RS02615	COG0561	phosphatase activity
S100141_RS02620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100141_RS02625	COG0475	glutathione-regulated potassium exporter activity
S100141_RS02630	COG0490	domain, Protein
S100141_RS02640	COG1024	Enoyl-CoA hydratase
S100141_RS02660	COG4152	abc transporter atp-binding protein
S100141_RS02665	COG1668	transmembrane transport
S100141_RS02670	COG0420	3'-5' exonuclease activity
S100141_RS02675	COG4717	serine-type aminopeptidase activity
S100141_RS02680	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100141_RS02690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100141_RS02720	COG1846	Transcriptional regulator
S100141_RS02725	COG4980	gas vesicle protein
S100141_RS02740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100141_RS02745	COG0537	adenosine 5'-monophosphoramidase activity
S100141_RS02755	COG1131	(ABC) transporter
S100141_RS02760	COG4473	ABC transporter
S100141_RS02770	COG1473	amidohydrolase
S100141_RS02775	COG3069	C4-dicarboxylate transmembrane transporter activity
S100141_RS02780	COG2329	Antibiotic biosynthesis monooxygenase
S100141_RS02785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100141_RS02790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S100141_RS02795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S100141_RS02800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S100141_RS02805	COG1309	transcriptional regulator
S100141_RS02810	COG1511	domain protein
S100141_RS02815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100141_RS02820	COG1363	Peptidase, m42
S100141_RS02830	COG1301	dicarboxylic acid transport
S100141_RS02840	COG1234	tRNA 3'-trailer cleavage
S100141_RS02845	COG0095	Lipoate-protein ligase
S100141_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS02860	COG1396	sequence-specific DNA binding
S100141_RS02875	COG0501	Belongs to the peptidase M48B family
S100141_RS02885	COG0697	spore germination
S100141_RS02890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100141_RS02895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS02900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS02905	COG0406	alpha-ribazole phosphatase activity
S100141_RS02910	COG0840	transmembrane signaling receptor activity
S100141_RS02915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100141_RS02915	COG0723	plastoquinol--plastocyanin reductase activity
S100141_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS02930	COG4903	ComK protein
S100141_RS02940	COG0398	Pfam SNARE associated Golgi protein
S100141_RS02945	COG0681	Belongs to the peptidase S26 family
S100141_RS02950	COG1404	Belongs to the peptidase S8 family
S100141_RS02960	COG2508	Transcriptional regulator
S100141_RS02970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100141_RS02975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100141_RS02980	COG3257	ureidoglycine aminohydrolase activity
S100141_RS02985	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100141_RS02995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100141_RS03000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100141_RS03010	COG0549	Belongs to the carbamate kinase family
S100141_RS03015	COG2814	Major facilitator Superfamily
S100141_RS03025	COG0457	Tetratricopeptide repeat
S100141_RS03045	COG1609	Transcriptional regulator
S100141_RS03050	COG1653	transport
S100141_RS03055	COG1175	transmembrane transport
S100141_RS03060	COG0395	ABC-type sugar transport system, permease component
S100141_RS03065	COG1486	melibiose metabolic process
S100141_RS03070	COG3180	Ammonia monooxygenase
S100141_RS03085	COG3546	catalase activity
S100141_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS03095	COG2814	Major facilitator Superfamily
S100141_RS03095	COG0477	Major facilitator Superfamily
S100141_RS03105	COG5002	protein histidine kinase activity
S100141_RS03110	COG0745	RESPONSE REGULATOR receiver
S100141_RS03115	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S100141_RS03120	COG0725	ABC transporter, periplasmic molybdate-binding protein
S100141_RS03125	COG4149	molybdate abc transporter
S100141_RS03130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100141_RS03135	COG1074	ATP-dependent DNA helicase activity
S100141_RS03140	COG0420	3'-5' exonuclease activity
S100141_RS03145	COG0419	ATPase involved in DNA repair
S100141_RS03190	COG5337	Spore coat protein CotH
S100141_RS03200	COG0179	Fumarylacetoacetate (FAA) hydrolase
S100141_RS03220	COG0367	asparagine synthase
S100141_RS03230	COG0347	Belongs to the P(II) protein family
S100141_RS03235	COG0534	Mate efflux family protein
S100141_RS03240	COG2207	Transcriptional regulator
S100141_RS03240	COG1917	Cupin 2, conserved barrel domain protein
S100141_RS03250	COG1609	Transcriptional regulator
S100141_RS03260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100141_RS03270	COG0076	glutamate decarboxylase activity
S100141_RS03295	COG2153	protein acetylation
S100141_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS03305	COG2378	regulation of single-species biofilm formation
S100141_RS03310	COG1410	methionine synthase
S100141_RS03310	COG0646	methionine synthase
S100141_RS03315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100141_RS03315	COG0646	methionine synthase
S100141_RS03320	COG1666	GTP binding
S100141_RS03325	COG2996	Protein conserved in bacteria
S100141_RS03340	COG1307	EDD domain protein, DegV family
S100141_RS03345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS03355	COG0516	GMP reductase activity
S100141_RS03365	COG0561	phosphatase activity
S100141_RS03370	COG1073	alpha beta
S100141_RS03375	COG2151	metal-sulfur cluster biosynthetic enzyme
S100141_RS03385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100141_RS03390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S100141_RS03395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S100141_RS03400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100141_RS03405	COG0505	Belongs to the CarA family
S100141_RS03410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100141_RS03415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100141_RS03420	COG1968	undecaprenyl-diphosphatase activity
S100141_RS03435	COG2267	carboxylic ester hydrolase activity
S100141_RS03445	COG1744	ABC transporter substrate-binding protein PnrA-like
S100141_RS03460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100141_RS03465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100141_RS03470	COG5504	Zn-dependent protease
S100141_RS03475	COG0444	Belongs to the ABC transporter superfamily
S100141_RS03480	COG4608	Belongs to the ABC transporter superfamily
S100141_RS03490	COG0601	transmembrane transport
S100141_RS03495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS03520	COG0180	Tryptophanyl-tRNA synthetase
S100141_RS03530	COG4166	transmembrane transport
S100141_RS03535	COG0601	transmembrane transport
S100141_RS03540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS03545	COG0444	Belongs to the ABC transporter superfamily
S100141_RS03550	COG4608	Belongs to the ABC transporter superfamily
S100141_RS03555	COG0456	acetyltransferase
S100141_RS03560	COG1393	Belongs to the ArsC family
S100141_RS03565	COG0861	Integral membrane protein TerC family
S100141_RS03570	COG4862	establishment of competence for transformation
S100141_RS03590	COG4565	transcriptional regulatory protein
S100141_RS03600	COG4469	Competence protein
S100141_RS03605	COG1164	Oligoendopeptidase f
S100141_RS03615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100141_RS03620	COG2346	COG2346, Truncated hemoglobins
S100141_RS03625	COG0741	lytic transglycosylase activity
S100141_RS03630	COG4116	CYTH
S100141_RS03640	COG2357	RelA SpoT domain protein
S100141_RS03645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100141_RS03650	COG0564	pseudouridine synthase activity
S100141_RS03655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100141_RS03665	COG0569	domain protein
S100141_RS03665	COG0475	glutathione-regulated potassium exporter activity
S100141_RS03670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100141_RS03675	COG0352	thiamine-phosphate diphosphorylase activity
S100141_RS03685	COG2104	thiamine diphosphate biosynthetic process
S100141_RS03690	COG2022	thiamine diphosphate biosynthetic process
S100141_RS03695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100141_RS03700	COG0351	phosphomethylpyrimidine kinase
S100141_RS03705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100141_RS03760	COG0210	DNA helicase
S100141_RS03770	COG0586	Pfam SNARE associated Golgi protein
S100141_RS03775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100141_RS03780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100141_RS03785	COG2246	polysaccharide biosynthetic process
S100141_RS03790	COG2153	protein acetylation
S100141_RS03795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100141_RS03800	COG2382	esterase
S100141_RS03820	COG0626	cystathionine gamma-synthase activity
S100141_RS03825	COG0626	cystathionine gamma-synthase activity
S100141_RS03830	COG5505	Protein of unknown function (DUF819)
S100141_RS03845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100141_RS03870	COG0110	maltose O-acetyltransferase activity
S100141_RS03880	COG0583	DNA-binding transcription factor activity
S100141_RS03890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100141_RS03895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100141_RS03900	COG0583	DNA-binding transcription factor activity
S100141_RS03905	COG0697	spore germination
S100141_RS03910	COG0346	lactoylglutathione lyase activity
S100141_RS03920	COG1388	LysM domain
S100141_RS03920	COG3584	3D domain protein
S100141_RS03925	COG2814	Major facilitator Superfamily
S100141_RS03930	COG1309	transcriptional regulator
S100141_RS03955	COG4195	phage-related replication protein
S100141_RS03960	COG2856	Zn peptidase
S100141_RS03965	COG1396	sequence-specific DNA binding
S100141_RS03980	COG1522	sequence-specific DNA binding
S100141_RS03985	COG1484	DNA-dependent DNA replication
S100141_RS04000	COG1595	DNA-templated transcription, initiation
S100141_RS04005	COG3728	DNA packaging
S100141_RS04005	COG5484	DNA packaging
S100141_RS04010	COG1783	phage Terminase large subunit
S100141_RS04015	COG5518	Phage portal protein
S100141_RS04020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S100141_RS04025	COG4653	Phage capsid family
S100141_RS04075	COG5412	phage tail tape measure protein
S100141_RS04075	COG3953	SLT domain
S100141_RS04080	COG1652	LysM domain
S100141_RS04085	COG4193	domain, Protein
S100141_RS04095	COG3628	GPW Gp25 family protein
S100141_RS04100	COG3299	homolog of phage Mu protein gp47
S100141_RS04105	COG3778	Protein conserved in bacteria
S100141_RS04140	COG1802	Transcriptional regulator
S100141_RS04145	COG1063	alcohol dehydrogenase
S100141_RS04150	COG1312	Catalyzes the dehydration of D-mannonate
S100141_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS04160	COG1063	alcohol dehydrogenase
S100141_RS04165	COG2271	Major facilitator Superfamily
S100141_RS04180	COG0306	phosphate transporter
S100141_RS04185	COG1392	Phosphate transport regulator
S100141_RS04190	COG0405	Gamma-glutamyltransferase
S100141_RS04200	COG2972	Histidine kinase
S100141_RS04210	COG1653	transport
S100141_RS04215	COG1175	transmembrane transport
S100141_RS04220	COG0395	ABC-type sugar transport system, permease component
S100141_RS04225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100141_RS04230	COG2207	Transcriptional regulator
S100141_RS04235	COG2755	lipolytic protein G-D-S-L family
S100141_RS04245	COG5578	integral membrane protein
S100141_RS04250	COG3401	FG-GAP repeat protein
S100141_RS04260	COG2755	lipolytic protein G-D-S-L family
S100141_RS04265	COG3401	FG-GAP repeat protein
S100141_RS04270	COG0667	Aldo Keto reductase
S100141_RS04275	COG2755	lipolytic protein G-D-S-L family
S100141_RS04280	COG1874	Beta-galactosidase
S100141_RS04290	COG1653	transport
S100141_RS04295	COG4209	transmembrane transport
S100141_RS04300	COG0395	ABC-type sugar transport system, permease component
S100141_RS04305	COG0531	amino acid
S100141_RS04310	COG0346	lactoylglutathione lyase activity
S100141_RS04320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100141_RS04325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100141_RS04330	COG2362	D-Aminopeptidase
S100141_RS04335	COG0601	transmembrane transport
S100141_RS04340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS04345	COG0444	Belongs to the ABC transporter superfamily
S100141_RS04350	COG4166	transmembrane transport
S100141_RS04355	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100141_RS04360	COG4948	Mandelate Racemase Muconate Lactonizing
S100141_RS04365	COG0791	NLP P60 protein
S100141_RS04370	COG4608	Belongs to the ABC transporter superfamily
S100141_RS04375	COG1834	amidinotransferase
S100141_RS04380	COG1607	acyl-coa hydrolase
S100141_RS04385	COG2323	membrane
S100141_RS04390	COG3866	Pectate lyase
S100141_RS04410	COG2318	DinB family
S100141_RS04415	COG2076	Multidrug Resistance protein
S100141_RS04420	COG2076	Multidrug Resistance protein
S100141_RS04425	COG0788	formyltetrahydrofolate deformylase activity
S100141_RS04430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100141_RS04435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100141_RS04440	COG1764	response to oxidative stress
S100141_RS04445	COG1846	Transcriptional regulator
S100141_RS04450	COG1764	response to oxidative stress
S100141_RS04460	COG0590	tRNA wobble adenosine to inosine editing
S100141_RS04465	COG0406	alpha-ribazole phosphatase activity
S100141_RS04480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100141_RS04485	COG1404	Belongs to the peptidase S8 family
S100141_RS04495	COG2239	Acts as a magnesium transporter
S100141_RS04505	COG0789	Transcriptional regulator
S100141_RS04520	COG1846	Transcriptional regulator
S100141_RS04525	COG3285	dna ligase
S100141_RS04525	COG1793	dna ligase
S100141_RS04530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S100141_RS04535	COG5001	Diguanylate cyclase
S100141_RS04535	COG3300	MHYT domain
S100141_RS04540	COG0586	Pfam SNARE associated Golgi protein
S100141_RS04545	COG0861	Integral membrane protein TerC family
S100141_RS04550	COG1191	sigma factor activity
S100141_RS04570	COG0501	Belongs to the peptidase M48B family
S100141_RS04575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100141_RS04580	COG0768	penicillin binding
S100141_RS04595	COG3594	Acyltransferase
S100141_RS04605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100141_RS04610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S100141_RS04615	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S100141_RS04620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100141_RS04625	COG0436	Aminotransferase
S100141_RS04630	COG1850	ribulose-bisphosphate carboxylase activity
S100141_RS04635	COG0235	Class ii aldolase
S100141_RS04635	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S100141_RS04640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S100141_RS04645	COG0346	lactoylglutathione lyase activity
S100141_RS04650	COG3339	Conserved Protein
S100141_RS04660	COG3852	Histidine kinase
S100141_RS04665	COG1846	Transcriptional regulator
S100141_RS04670	COG1360	Flagellar Motor Protein
S100141_RS04675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100141_RS04680	COG0542	response to heat
S100141_RS04685	COG3949	Membrane
S100141_RS04690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S100141_RS04695	COG0720	synthase
S100141_RS04700	COG0602	queuosine metabolic process
S100141_RS04705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S100141_RS04715	COG3739	integral membrane protein
S100141_RS04720	COG3655	Transcriptional regulator
S100141_RS04755	COG4873	Protein conserved in bacteria
S100141_RS04765	COG3773	Cell wall hydrolase
S100141_RS04770	COG2244	polysaccharide biosynthetic process
S100141_RS04775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS04780	COG2217	Heavy metal translocating P-type atpase
S100141_RS04785	COG0006	proline dipeptidase activity
S100141_RS04795	COG1609	Transcriptional regulator
S100141_RS04800	COG3711	transcriptional antiterminator
S100141_RS04805	COG2190	(PTS) system
S100141_RS04805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS04805	COG1263	PTS System
S100141_RS04810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS04815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100141_RS04825	COG1533	DNA photolyase activity
S100141_RS04830	COG0456	acetyltransferase
S100141_RS04835	COG0840	transmembrane signaling receptor activity
S100141_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS04845	COG2084	Dehydrogenase
S100141_RS04850	COG2340	Cysteine-rich secretory protein family
S100141_RS04855	COG0768	penicillin binding
S100141_RS04860	COG4191	Histidine kinase
S100141_RS04865	COG0436	Aminotransferase
S100141_RS04870	COG1714	RDD family
S100141_RS04880	COG0835	chemotaxis
S100141_RS04880	COG0784	Response regulator, receiver
S100141_RS04890	COG2814	Major facilitator Superfamily
S100141_RS04895	COG1376	ErfK ybiS ycfS ynhG family protein
S100141_RS04905	COG1408	metallophosphoesterase
S100141_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS04915	COG2200	EAL domain
S100141_RS04925	COG4703	Protein of unknown function (DUF1797)
S100141_RS04935	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S100141_RS04945	COG0517	IMP dehydrogenase activity
S100141_RS04950	COG0583	DNA-binding transcription factor activity
S100141_RS04955	COG0716	FMN binding
S100141_RS04965	COG0716	FMN binding
S100141_RS04970	COG2171	N-acyltransferase activity
S100141_RS04975	COG1473	amidohydrolase
S100141_RS04985	COG0450	alkyl hydroperoxide reductase
S100141_RS04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS05005	COG0746	molybdenum cofactor guanylyltransferase activity
S100141_RS05010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100141_RS05015	COG0303	'Molybdopterin
S100141_RS05020	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100141_RS05030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S100141_RS05040	COG1132	(ABC) transporter
S100141_RS05045	COG1132	(ABC) transporter
S100141_RS05055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100141_RS05060	COG1136	(ABC) transporter
S100141_RS05065	COG0577	efflux transmembrane transporter activity
S100141_RS05070	COG1349	DNA-binding transcription factor activity
S100141_RS05075	COG1105	Belongs to the carbohydrate kinase PfkB family
S100141_RS05080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS05080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS05080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS05100	COG0488	(ABC) transporter
S100141_RS05110	COG2309	aminopeptidase activity
S100141_RS05120	COG1077	Cell shape determining protein MreB Mrl
S100141_RS05125	COG2002	toxin-antitoxin pair type II binding
S100141_RS05130	COG3852	Histidine kinase
S100141_RS05135	COG0569	domain protein
S100141_RS05140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100141_RS05145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100141_RS05150	COG5503	Protein of unknown function (DUF1447)
S100141_RS05155	COG0561	phosphatase activity
S100141_RS05165	COG0242	peptide deformylase activity
S100141_RS05175	COG0497	DNA recombination
S100141_RS05180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100141_RS05185	COG0022	dehydrogenase e1 component
S100141_RS05190	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100141_RS05195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100141_RS05200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS05210	COG1982	Orn Lys Arg decarboxylase major
S100141_RS05215	COG4476	Belongs to the UPF0223 family
S100141_RS05220	COG4493	Belongs to the UPF0637 family
S100141_RS05230	COG0483	inositol monophosphate 1-phosphatase activity
S100141_RS05250	COG1595	DNA-templated transcription, initiation
S100141_RS05265	COG1217	gtp-binding protein TYPA
S100141_RS05275	COG1846	Transcriptional regulator
S100141_RS05280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100141_RS05285	COG4896	Protein conserved in bacteria
S100141_RS05295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100141_RS05300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100141_RS05305	COG2066	Belongs to the glutaminase family
S100141_RS05310	COG4838	Belongs to the UPF0358 family
S100141_RS05315	COG0772	Belongs to the SEDS family
S100141_RS05320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100141_RS05325	COG1612	heme a metabolic process
S100141_RS05330	COG0109	protoheme IX farnesyltransferase activity
S100141_RS05335	COG2010	Cytochrome c
S100141_RS05335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100141_RS05340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100141_RS05345	COG1845	cytochrome c oxidase, subunit III
S100141_RS05350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100141_RS05355	COG3336	cytochrome c oxidase
S100141_RS05365	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100141_RS05370	COG2340	Cysteine-rich secretory protein family
S100141_RS05385	COG3679	Belongs to the UPF0342 family
S100141_RS05390	COG4471	UPF0298 protein
S100141_RS05395	COG0742	ribosomal rna small subunit methyltransferase
S100141_RS05400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100141_RS05405	COG3314	Sporulation integral membrane protein YlbJ
S100141_RS05410	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100141_RS05415	COG1323	Belongs to the UPF0348 family
S100141_RS05420	COG1399	metal-binding, possibly nucleic acid-binding protein
S100141_RS05425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100141_RS05435	COG0454	-acetyltransferase
S100141_RS05440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100141_RS05445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S100141_RS05450	COG2001	Belongs to the MraZ family
S100141_RS05455	COG0275	rRNA processing
S100141_RS05460	COG4839	cell division protein FtsL
S100141_RS05465	COG0768	penicillin binding
S100141_RS05470	COG0768	penicillin binding
S100141_RS05475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100141_RS05480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100141_RS05485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100141_RS05490	COG0772	Belongs to the SEDS family
S100141_RS05495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100141_RS05500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100141_RS05505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100141_RS05510	COG3879	Bacterial protein of unknown function (DUF881)
S100141_RS05515	COG3879	Bacterial protein of unknown function (DUF881)
S100141_RS05520	COG3856	small basic protein
S100141_RS05525	COG0849	cell division
S100141_RS05530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S100141_RS05535	COG4412	M6 family metalloprotease domain protein
S100141_RS05535	COG1404	Belongs to the peptidase S8 family
S100141_RS05555	COG1191	sigma factor activity
S100141_RS05560	COG1191	sigma factor activity
S100141_RS05570	COG0500	methyltransferase
S100141_RS05575	COG1873	PFAM PRC-barrel domain
S100141_RS05580	COG1496	oxidoreductase activity
S100141_RS05585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S100141_RS05590	COG1799	cell septum assembly
S100141_RS05595	COG0762	integral membrane protein
S100141_RS05600	COG2302	S4 RNA-binding domain
S100141_RS05605	COG3599	regulation of cell shape
S100141_RS05610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100141_RS05615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100141_RS05620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100141_RS05625	COG0564	pseudouridine synthase activity
S100141_RS05630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100141_RS05635	COG2233	PERMEase
S100141_RS05640	COG0540	Belongs to the ATCase OTCase family
S100141_RS05645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100141_RS05650	COG0505	Belongs to the CarA family
S100141_RS05655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100141_RS05660	COG0543	2 iron, 2 sulfur cluster binding
S100141_RS05665	COG0167	dihydroorotate dehydrogenase activity
S100141_RS05670	COG0284	orotidine-5'-phosphate decarboxylase activity
S100141_RS05675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100141_RS05685	COG0175	sulfate reduction
S100141_RS05690	COG0306	phosphate transporter
S100141_RS05695	COG2046	Belongs to the sulfate adenylyltransferase family
S100141_RS05700	COG0529	Catalyzes the synthesis of activated sulfate
S100141_RS05705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100141_RS05710	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S100141_RS05715	COG1648	precorrin-2 dehydrogenase activity
S100141_RS05725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100141_RS05730	COG1561	YicC-like family, N-terminal region
S100141_RS05735	COG2052	Domain of unknown function (DUF370)
S100141_RS05740	COG0194	GDP metabolic process
S100141_RS05745	COG1758	RNA polymerase activity
S100141_RS05750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100141_RS05755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100141_RS05760	COG0242	peptide deformylase activity
S100141_RS05765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100141_RS05770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100141_RS05770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100141_RS05775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S100141_RS05780	COG0631	protein serine/threonine phosphatase activity
S100141_RS05785	COG0515	serine threonine protein kinase
S100141_RS05785	COG2815	serine threonine protein kinase
S100141_RS05790	COG1162	GTPase activity
S100141_RS05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100141_RS05800	COG1564	THIamine pyrophosphokinase
S100141_RS05810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100141_RS05815	COG1302	Protein conserved in bacteria
S100141_RS05820	COG1461	Dihydroxyacetone kinase
S100141_RS05825	COG1760	l-serine dehydratase
S100141_RS05830	COG1760	l-serine dehydratase
S100141_RS05835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100141_RS05840	COG1349	DNA-binding transcription factor activity
S100141_RS05845	COG0416	fatty acid biosynthetic process
S100141_RS05850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100141_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS05860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100141_RS05865	COG0571	ribonuclease III activity
S100141_RS05870	COG1196	nuclear chromosome segregation
S100141_RS05875	COG0552	protein localization to endoplasmic reticulum
S100141_RS05880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100141_RS05885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100141_RS05890	COG0228	four-way junction DNA binding
S100141_RS05895	COG1837	Belongs to the UPF0109 family
S100141_RS05905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100141_RS05910	COG0336	Belongs to the RNA methyltransferase TrmD family
S100141_RS05915	COG0335	large ribosomal subunit rRNA binding
S100141_RS05920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100141_RS05925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100141_RS05935	COG2257	FlhB HrpN YscU SpaS Family
S100141_RS05945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100141_RS05950	COG0758	DNA mediated transformation
S100141_RS05955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100141_RS05960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100141_RS05965	COG4974	Belongs to the 'phage' integrase family
S100141_RS05970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100141_RS05975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100141_RS05980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100141_RS05985	COG1815	bacterial-type flagellum-dependent cell motility
S100141_RS05990	COG1558	bacterial-type flagellum-dependent cell motility
S100141_RS05995	COG1677	Flagellar hook-basal body complex protein FliE
S100141_RS06000	COG1766	The M ring may be actively involved in energy transduction
S100141_RS06005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100141_RS06010	COG1317	bacterial-type flagellum organization
S100141_RS06015	COG1157	protein secretion by the type III secretion system
S100141_RS06020	COG2882	bacterial-type flagellum organization
S100141_RS06030	COG3144	bacterial-type flagellum assembly
S100141_RS06035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S100141_RS06040	COG4786	Flagellar basal body rod
S100141_RS06045	COG1582	Flagellar protein (FlbD)
S100141_RS06050	COG1580	Controls the rotational direction of flagella during chemotaxis
S100141_RS06055	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100141_RS06060	COG1776	CheC inhibitor of MCP methylation
S100141_RS06060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100141_RS06065	COG2201	protein-glutamate methylesterase activity
S100141_RS06070	COG3190	flagellar
S100141_RS06075	COG1338	Plays a role in the flagellum-specific transport system
S100141_RS06080	COG1987	bacterial-type flagellum assembly
S100141_RS06085	COG1684	flagellar biosynthetic protein fliR
S100141_RS06090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100141_RS06095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100141_RS06100	COG1419	protein localization to endoplasmic reticulum
S100141_RS06105	COG0455	bacterial-type flagellum organization
S100141_RS06110	COG2201	protein-glutamate methylesterase activity
S100141_RS06115	COG2198	Histidine kinase
S100141_RS06115	COG0643	Histidine kinase
S100141_RS06120	COG0835	chemotaxis
S100141_RS06125	COG1776	CheC inhibitor of MCP methylation
S100141_RS06130	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S100141_RS06135	COG1191	sigma factor activity
S100141_RS06145	COG0052	Belongs to the universal ribosomal protein uS2 family
S100141_RS06150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100141_RS06155	COG0528	UMP kinase activity
S100141_RS06160	COG0233	cytoplasmic translational termination
S100141_RS06165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100141_RS06170	COG4589	Belongs to the CDS family
S100141_RS06175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S100141_RS06180	COG0750	zinc metalloprotease
S100141_RS06185	COG0442	prolyl-tRNA aminoacylation
S100141_RS06190	COG2176	DNA-directed DNA polymerase activity
S100141_RS06220	COG0779	Required for maturation of 30S ribosomal subunits
S100141_RS06225	COG0195	Participates in both transcription termination and antitermination
S100141_RS06230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100141_RS06235	COG1358	cellular component organization or biogenesis
S100141_RS06240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100141_RS06245	COG1550	Protein conserved in bacteria
S100141_RS06250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100141_RS06255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100141_RS06260	COG0196	riboflavin kinase activity
S100141_RS06265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100141_RS06270	COG1185	polyribonucleotide nucleotidyltransferase activity
S100141_RS06275	COG0726	polysaccharide deacetylase
S100141_RS06280	COG0612	Peptidase, M16
S100141_RS06285	COG1873	PFAM PRC-barrel domain
S100141_RS06290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100141_RS06295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100141_RS06300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100141_RS06305	COG0527	aspartate kinase activity
S100141_RS06315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100141_RS06320	COG0740	serine-type endopeptidase activity
S100141_RS06330	COG4980	gas vesicle protein
S100141_RS06330	COG1674	ftsk spoiiie
S100141_RS06335	COG2188	Transcriptional regulator
S100141_RS06340	COG2814	Major facilitator Superfamily
S100141_RS06345	COG0612	Peptidase, M16
S100141_RS06350	COG0612	Peptidase, M16
S100141_RS06355	COG0300	oxidoreductase activity
S100141_RS06370	COG1426	Protein conserved in bacteria
S100141_RS06375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100141_RS06380	COG1058	Belongs to the CinA family
S100141_RS06380	COG1546	Belongs to the CinA family
S100141_RS06390	COG1418	mRNA catabolic process
S100141_RS06395	COG1692	metallophosphoesterase
S100141_RS06400	COG2359	stage V sporulation protein S
S100141_RS06410	COG1063	alcohol dehydrogenase
S100141_RS06415	COG0156	8-amino-7-oxononanoate synthase activity
S100141_RS06420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100141_RS06425	COG4550	Control of competence regulator ComK, YlbF/YmcA
S100141_RS06435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100141_RS06440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100141_RS06445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100141_RS06450	COG5444	nuclease activity
S100141_RS06470	COG0523	cobalamin synthesis protein
S100141_RS06480	COG1247	-acetyltransferase
S100141_RS06495	COG1231	oxidoreductase activity
S100141_RS06500	COG3619	membrane
S100141_RS06505	COG3263	regulation of cellular component size
S100141_RS06515	COG2267	carboxylic ester hydrolase activity
S100141_RS06525	COG0393	Putative heavy-metal-binding
S100141_RS06530	COG0398	Pfam SNARE associated Golgi protein
S100141_RS06535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100141_RS06540	COG1819	glycosyl
S100141_RS06545	COG0531	amino acid
S100141_RS06550	COG5577	PFAM Coat F domain
S100141_RS06560	COG1388	LysM domain
S100141_RS06560	COG3858	chitin binding
S100141_RS06565	COG1309	transcriptional regulator
S100141_RS06570	COG3631	Ketosteroid isomerase-related protein
S100141_RS06575	COG0702	epimerase
S100141_RS06585	COG1764	response to oxidative stress
S100141_RS06590	COG2076	Multidrug Resistance protein
S100141_RS06595	COG2076	Multidrug Resistance protein
S100141_RS06610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100141_RS06615	COG1923	regulation of RNA biosynthetic process
S100141_RS06630	COG1780	Probably involved in ribonucleotide reductase function
S100141_RS06635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS06640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS06645	COG4112	unkown
S100141_RS06655	COG0822	iron-sulfur transferase activity
S100141_RS06660	COG0735	belongs to the Fur family
S100141_RS06665	COG1802	Transcriptional regulator
S100141_RS06670	COG0697	spore germination
S100141_RS06705	COG1309	transcriptional regulator
S100141_RS06740	COG4282	regulation of fungal-type cell wall biogenesis
S100141_RS06745	COG5444	nuclease activity
S100141_RS06775	COG0464	growth
S100141_RS06780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100141_RS06785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100141_RS06790	COG0789	Transcriptional regulator
S100141_RS06795	COG0174	glutamine synthetase
S100141_RS06880	COG1309	transcriptional regulator
S100141_RS06885	COG2076	Multidrug Resistance protein
S100141_RS06890	COG2076	Multidrug Resistance protein
S100141_RS06915	COG3546	catalase activity
S100141_RS06940	COG1846	Transcriptional regulator
S100141_RS06950	COG0346	lactoylglutathione lyase activity
S100141_RS06955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100141_RS06960	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100141_RS06980	COG3209	COG3209 Rhs family protein
S100141_RS06985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100141_RS06990	COG1388	LysM domain
S100141_RS06995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100141_RS07000	COG4224	UPF0291 protein
S100141_RS07005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100141_RS07015	COG3763	UPF0154 protein
S100141_RS07025	COG0785	Cytochrome C biogenesis protein
S100141_RS07030	COG2201	protein-glutamate methylesterase activity
S100141_RS07035	COG4846	Membrane protein involved in cytochrome C biogenesis
S100141_RS07045	COG0071	Belongs to the small heat shock protein (HSP20) family
S100141_RS07060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S100141_RS07065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS07085	COG0824	Thioesterase
S100141_RS07110	COG4841	protein insertion into membrane
S100141_RS07115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100141_RS07120	COG1832	CoA-binding protein
S100141_RS07125	COG0187	DNA topoisomerase II activity
S100141_RS07130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100141_RS07135	COG1609	Transcriptional regulator
S100141_RS07150	COG2160	L-arabinose isomerase activity
S100141_RS07170	COG1115	amino acid carrier protein
S100141_RS07180	COG2181	nitrate reductase activity
S100141_RS07185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S100141_RS07190	COG1140	nitrate reductase beta subunit
S100141_RS07195	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S100141_RS07210	COG0535	radical SAM domain protein
S100141_RS07215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100141_RS07225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100141_RS07230	COG2223	nitrite transmembrane transporter activity
S100141_RS07250	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
S100141_RS07260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S100141_RS07270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS07280	COG0492	ferredoxin-NADP+ reductase activity
S100141_RS07295	COG3420	alginic acid biosynthetic process
S100141_RS07300	COG1114	Component of the transport system for branched-chain amino acids
S100141_RS07305	COG1064	alcohol dehydrogenase
S100141_RS07310	COG0789	Transcriptional regulator
S100141_RS07335	COG1024	Enoyl-CoA hydratase
S100141_RS07340	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS07345	COG2084	Dehydrogenase
S100141_RS07350	COG1960	acyl-CoA dehydrogenase activity
S100141_RS07355	COG1482	cell wall glycoprotein biosynthetic process
S100141_RS07360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS07360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS07360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS07380	COG3711	transcriptional antiterminator
S100141_RS07395	COG1725	Transcriptional regulator
S100141_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS07405	COG1312	Catalyzes the dehydration of D-mannonate
S100141_RS07420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S100141_RS07430	COG1609	Transcriptional regulator
S100141_RS07435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100141_RS07440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100141_RS07445	COG0640	Transcriptional regulator
S100141_RS07455	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S100141_RS07470	COG1649	PFAM Uncharacterised BCR, COG1649
S100141_RS07480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S100141_RS07490	COG2027	D-alanyl-D-alanine carboxypeptidase
S100141_RS07495	COG2323	membrane
S100141_RS07500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100141_RS07510	COG2323	membrane
S100141_RS07525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100141_RS07540	COG3546	catalase activity
S100141_RS07560	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS07595	COG0166	Belongs to the GPI family
S100141_RS07605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100141_RS07610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100141_RS07615	COG1024	Enoyl-CoA hydratase
S100141_RS07620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100141_RS07625	COG0511	ligase activity, forming carbon-carbon bonds
S100141_RS07630	COG0439	Biotin carboxylase
S100141_RS07635	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS07640	COG1960	acyl-CoA dehydrogenase activity
S100141_RS07645	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100141_RS07650	COG1733	regulation of RNA biosynthetic process
S100141_RS07655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100141_RS07660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100141_RS07675	COG0306	phosphate transporter
S100141_RS07680	COG0175	sulfate reduction
S100141_RS07685	COG1809	phosphosulfolactate synthase activity
S100141_RS07690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS07695	COG4948	Mandelate Racemase Muconate Lactonizing
S100141_RS07700	COG2814	Major facilitator Superfamily
S100141_RS07705	COG0463	Glycosyl transferase, family 2
S100141_RS07720	COG0493	'glutamate synthase
S100141_RS07725	COG0070	glutamate synthase
S100141_RS07725	COG0069	glutamate synthase activity
S100141_RS07725	COG0067	glutamate synthase
S100141_RS07730	COG0583	DNA-binding transcription factor activity
S100141_RS07750	COG1846	Transcriptional regulator
S100141_RS07760	COG1132	(ABC) transporter
S100141_RS07770	COG0300	oxidoreductase activity
S100141_RS07785	COG0477	Major facilitator Superfamily
S100141_RS07790	COG0243	molybdopterin cofactor binding
S100141_RS07795	COG1846	Transcriptional regulator
S100141_RS07800	COG2814	Major facilitator Superfamily
S100141_RS07805	COG0531	amino acid
S100141_RS07820	COG0531	amino acid
S100141_RS07825	COG0697	spore germination
S100141_RS07835	COG0488	(ABC) transporter
S100141_RS07840	COG0840	transmembrane signaling receptor activity
S100141_RS07845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100141_RS07850	COG1404	Belongs to the peptidase S8 family
S100141_RS07860	COG1309	transcriptional regulator
S100141_RS07865	COG1846	Transcriptional regulator
S100141_RS07895	COG1309	transcriptional regulator
S100141_RS07900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS07905	COG3708	Transcriptional regulator
S100141_RS07915	COG2378	regulation of single-species biofilm formation
S100141_RS07925	COG0640	Transcriptional regulator
S100141_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS07940	COG0531	amino acid
S100141_RS07945	COG0741	lytic transglycosylase activity
S100141_RS07950	COG1086	Polysaccharide biosynthesis protein
S100141_RS07970	COG2322	membrane
S100141_RS07985	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS07990	COG3584	3D domain protein
S100141_RS07990	COG1388	LysM domain
S100141_RS07995	COG0514	ATP-dependent DNA helicase (RecQ)
S100141_RS08015	COG2315	Protein conserved in bacteria
S100141_RS08035	COG2427	Protein of unknown function (DUF1641)
S100141_RS08040	COG3383	formate dehydrogenase (NAD+) activity
S100141_RS08060	COG5444	nuclease activity
S100141_RS08070	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S100141_RS08115	COG0402	S-adenosylhomocysteine deaminase activity
S100141_RS08130	COG2267	carboxylic ester hydrolase activity
S100141_RS08145	COG1280	lysine exporter protein (LysE YggA)
S100141_RS08150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100141_RS08160	COG3848	Pyruvate phosphate dikinase
S100141_RS08160	COG0574	Belongs to the PEP-utilizing enzyme family
S100141_RS08165	COG1309	transcriptional regulator
S100141_RS08180	COG2318	DinB family
S100141_RS08185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100141_RS08190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100141_RS08205	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS08210	COG2814	Major facilitator Superfamily
S100141_RS08225	COG1657	PFAM Prenyltransferase squalene oxidase
S100141_RS08230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100141_RS08240	COG0733	neurotransmitter:sodium symporter activity
S100141_RS08245	COG0385	Bile acid
S100141_RS08250	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100141_RS08255	COG0567	Dehydrogenase, E1 component
S100141_RS08260	COG4548	von Willebrand factor, type A
S100141_RS08265	COG0714	Associated with various cellular activities
S100141_RS08270	COG2032	superoxide dismutase activity
S100141_RS08275	COG0791	NLP P60 protein
S100141_RS08275	COG1388	LysM domain
S100141_RS08285	COG0534	Mate efflux family protein
S100141_RS08290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100141_RS08295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100141_RS08305	COG2962	Rard protein
S100141_RS08315	COG4305	rare lipoprotein A
S100141_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS08330	COG1733	regulation of RNA biosynthetic process
S100141_RS08335	COG0778	Nitroreductase
S100141_RS08340	COG0400	carboxylic ester hydrolase activity
S100141_RS08350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS08360	COG3409	Peptidoglycan-binding domain 1 protein
S100141_RS08360	COG0793	Belongs to the peptidase S41A family
S100141_RS08365	COG2226	methyltransferase
S100141_RS08375	COG1876	peptidase activity
S100141_RS08380	COG0813	purine-nucleoside phosphorylase activity
S100141_RS08385	COG0701	Predicted permease
S100141_RS08405	COG0671	phosphoesterase, PA-phosphatase related
S100141_RS08425	COG4479	Belongs to the UPF0346 family
S100141_RS08435	COG1509	lysine 2,3-aminomutase activity
S100141_RS08440	COG0456	acetyltransferase
S100141_RS08445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100141_RS08450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100141_RS08455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100141_RS08460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100141_RS08475	COG0456	acetyltransferase
S100141_RS08480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100141_RS08485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100141_RS08490	COG1846	Transcriptional regulator
S100141_RS08500	COG3706	GGDEF domain
S100141_RS08505	COG0534	Mate efflux family protein
S100141_RS08520	COG4698	Protein conserved in bacteria
S100141_RS08525	COG2755	lipolytic protein G-D-S-L family
S100141_RS08530	COG1999	signal sequence binding
S100141_RS08545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S100141_RS08550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100141_RS08555	COG1272	protein, Hemolysin III
S100141_RS08560	COG0204	Acyl-transferase
S100141_RS08565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100141_RS08575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100141_RS08585	COG2521	methyltransferase
S100141_RS08585	COG2136	Putative SAM-dependent methyltransferase
S100141_RS08595	COG0129	dihydroxy-acid dehydratase activity
S100141_RS08600	COG1413	lyase activity
S100141_RS08605	COG1418	mRNA catabolic process
S100141_RS08610	COG0386	Belongs to the glutathione peroxidase family
S100141_RS08615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S100141_RS08620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100141_RS08625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100141_RS08635	COG1278	Cold shock
S100141_RS08655	COG0328	RNA-DNA hybrid ribonuclease activity
S100141_RS08660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S100141_RS08665	COG0328	RNA-DNA hybrid ribonuclease activity
S100141_RS08675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100141_RS08690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100141_RS08700	COG1755	Isoprenylcysteine carboxyl methyltransferase
S100141_RS08705	COG3424	synthase
S100141_RS08710	COG0456	acetyltransferase
S100141_RS08715	COG2233	PERMEase
S100141_RS08720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100141_RS08725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S100141_RS08730	COG1199	ATP-dependent helicase activity
S100141_RS08745	COG0116	Belongs to the methyltransferase superfamily
S100141_RS08755	COG3599	regulation of cell shape
S100141_RS08760	COG4474	Belongs to the UPF0398 family
S100141_RS08770	COG3359	exonuclease
S100141_RS08775	COG1205	dead DEAH box helicase
S100141_RS08775	COG1111	helicase
S100141_RS08780	COG2190	(PTS) system
S100141_RS08785	COG0071	Belongs to the small heat shock protein (HSP20) family
S100141_RS08820	COG3331	DNA recombination
S100141_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100141_RS08825	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100141_RS08835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100141_RS08840	COG3935	DnaD domain protein
S100141_RS08845	COG0017	Asparaginyl-tRNA synthetase
S100141_RS08850	COG0436	Aminotransferase
S100141_RS08855	COG5353	protein conserved in bacteria
S100141_RS08865	COG1199	ATP-dependent helicase activity
S100141_RS08865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100141_RS08870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S100141_RS08875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S100141_RS08880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S100141_RS08895	COG0617	tRNA 3'-terminal CCA addition
S100141_RS08900	COG0438	transferase activity, transferring glycosyl groups
S100141_RS08905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100141_RS08910	COG1803	Methylglyoxal synthase
S100141_RS08915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100141_RS08920	COG1694	Mazg nucleotide pyrophosphohydrolase
S100141_RS08925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS08935	COG4347	Protein of unknown function (DUF1405)
S100141_RS08940	COG2010	Cytochrome c
S100141_RS08940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100141_RS08945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100141_RS08950	COG0723	plastoquinol--plastocyanin reductase activity
S100141_RS08960	COG5582	Belongs to the UPF0302 family
S100141_RS08965	COG0457	Tetratricopeptide repeat
S100141_RS08970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100141_RS08975	COG0287	Prephenate dehydrogenase
S100141_RS08980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S100141_RS08985	COG0159	tryptophan synthase activity
S100141_RS08990	COG0133	tryptophan synthase activity
S100141_RS08995	COG0135	phosphoribosylanthranilate isomerase activity
S100141_RS09000	COG0134	indole-3-glycerol-phosphate synthase activity
S100141_RS09005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100141_RS09010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100141_RS09015	COG4401	Chorismate mutase type I
S100141_RS09020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100141_RS09025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100141_RS09030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S100141_RS09035	COG0105	UTP biosynthetic process
S100141_RS09040	COG0142	geranyltranstransferase activity
S100141_RS09045	COG2226	methyltransferase
S100141_RS09050	COG0142	geranyltranstransferase activity
S100141_RS09065	COG0776	regulation of translation
S100141_RS09070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100141_RS09090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100141_RS09095	COG1160	GTP binding
S100141_RS09120	COG1304	FMN binding
S100141_RS09125	COG0539	negative regulation of cytoplasmic translation
S100141_RS09130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100141_RS09140	COG2959	enzyme of heme biosynthesis
S100141_RS09145	COG3773	Cell wall hydrolase
S100141_RS09145	COG3409	Peptidoglycan-binding domain 1 protein
S100141_RS09150	COG2339	peptidase activity
S100141_RS09160	COG0492	ferredoxin-NADP+ reductase activity
S100141_RS09165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100141_RS09170	COG4862	establishment of competence for transformation
S100141_RS09175	COG1408	metallophosphoesterase
S100141_RS09185	COG1388	LysM domain
S100141_RS09190	COG1266	CAAX protease self-immunity
S100141_RS09195	COG0514	ATP-dependent DNA helicase (RecQ)
S100141_RS09200	COG4955	Helix-turn-helix domain
S100141_RS09205	COG1141	Ferredoxin
S100141_RS09210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100141_RS09215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100141_RS09220	COG0739	heme binding
S100141_RS09230	COG1595	DNA-templated transcription, initiation
S100141_RS09235	COG1316	TRANSCRIPTIONal
S100141_RS09250	COG5002	protein histidine kinase activity
S100141_RS09255	COG0745	RESPONSE REGULATOR receiver
S100141_RS09260	COG5002	protein histidine kinase activity
S100141_RS09265	COG0745	RESPONSE REGULATOR receiver
S100141_RS09270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100141_RS09275	COG1333	cytochrome c biogenesis protein
S100141_RS09280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS09285	COG1187	pseudouridine synthase activity
S100141_RS09290	COG0700	Nucleoside recognition
S100141_RS09295	COG2715	membrane protein required for spore maturation
S100141_RS09300	COG1686	Belongs to the peptidase S11 family
S100141_RS09310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100141_RS09315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100141_RS09325	COG1547	Domain of unknown function (DUF309)
S100141_RS09330	COG0456	acetyltransferase
S100141_RS09335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100141_RS09340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100141_RS09340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100141_RS09345	COG0307	riboflavin synthase, alpha
S100141_RS09350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100141_RS09350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100141_RS09375	COG0457	Tetratricopeptide repeat
S100141_RS09380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100141_RS09385	COG4086	secreted protein
S100141_RS09390	COG4195	phage-related replication protein
S100141_RS09395	COG0019	diaminopimelate decarboxylase activity
S100141_RS09405	COG0697	spore germination
S100141_RS09420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100141_RS09445	COG2172	sigma factor antagonist activity
S100141_RS09455	COG1686	Belongs to the peptidase S11 family
S100141_RS09460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S100141_RS09465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100141_RS09470	COG4974	Belongs to the 'phage' integrase family
S100141_RS09480	COG0735	belongs to the Fur family
S100141_RS09485	COG1300	Membrane
S100141_RS09490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS09510	COG2153	protein acetylation
S100141_RS09515	COG1379	DNA repair
S100141_RS09520	COG0494	nUDIX hydrolase
S100141_RS09530	COG1309	transcriptional regulator
S100141_RS09540	COG0667	Aldo Keto reductase
S100141_RS09550	COG1073	alpha beta
S100141_RS09560	COG4918	Iron-sulphur cluster biosynthesis
S100141_RS09570	COG0456	acetyltransferase
S100141_RS09570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100141_RS09575	COG2329	Antibiotic biosynthesis monooxygenase
S100141_RS09585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100141_RS09595	COG0747	negative chemotaxis
S100141_RS09600	COG0601	transmembrane transport
S100141_RS09605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS09610	COG0444	Belongs to the ABC transporter superfamily
S100141_RS09615	COG0534	Mate efflux family protein
S100141_RS09630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100141_RS09640	COG2211	Major facilitator Superfamily
S100141_RS09645	COG0346	lactoylglutathione lyase activity
S100141_RS09650	COG1072	(Pantothenic acid kinase))
S100141_RS09665	COG1131	(ABC) transporter
S100141_RS09685	COG4195	phage-related replication protein
S100141_RS09695	COG0300	oxidoreductase activity
S100141_RS09700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS09705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100141_RS09710	COG4187	Peptidase family M20/M25/M40
S100141_RS09715	COG1902	pentaerythritol trinitrate reductase activity
S100141_RS09725	COG0596	Alpha beta hydrolase
S100141_RS09730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100141_RS09735	COG1234	tRNA 3'-trailer cleavage
S100141_RS09740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100141_RS09755	COG2358	TRAP transporter, solute receptor (TAXI family
S100141_RS09760	COG2188	Transcriptional regulator
S100141_RS09765	COG2723	6-phospho-beta-galactosidase activity
S100141_RS09770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS09775	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100141_RS09780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS09785	COG1785	Belongs to the alkaline phosphatase family
S100141_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS09795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100141_RS09800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100141_RS09810	COG0706	membrane insertase activity
S100141_RS09815	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100141_RS09820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100141_RS09825	COG4129	membrane
S100141_RS09830	COG1126	abc transporter atp-binding protein
S100141_RS09835	COG0765	amino acid transport
S100141_RS09840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100141_RS09850	COG1597	lipid kinase activity
S100141_RS09855	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100141_RS09860	COG0022	dehydrogenase e1 component
S100141_RS09865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100141_RS09870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100141_RS09875	COG3426	butyrate kinase activity
S100141_RS09885	COG0280	phosphate acetyltransferase
S100141_RS09890	COG3829	transcription factor binding
S100141_RS09890	COG3290	protein histidine kinase activity
S100141_RS09900	COG0584	glycerophosphoryl diester phosphodiesterase
S100141_RS09905	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS09920	COG1045	serine acetyltransferase
S100141_RS09930	COG0745	RESPONSE REGULATOR receiver
S100141_RS09935	COG0750	zinc metalloprotease
S100141_RS09940	COG0497	DNA recombination
S100141_RS09945	COG1438	arginine binding
S100141_RS09950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100141_RS09955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100141_RS09960	COG0142	geranyltranstransferase activity
S100141_RS09965	COG1722	exodeoxyribonuclease VII activity
S100141_RS09970	COG1570	exodeoxyribonuclease VII activity
S100141_RS09975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100141_RS09980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100141_RS09985	COG1302	Protein conserved in bacteria
S100141_RS09990	COG0439	Biotin carboxylase
S100141_RS09995	COG0511	ligase activity, forming carbon-carbon bonds
S100141_RS10035	COG3854	ATPases associated with a variety of cellular activities
S100141_RS10045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100141_RS10050	COG0006	proline dipeptidase activity
S100141_RS10055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S100141_RS10065	COG3872	metal-dependent enzyme
S100141_RS10075	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100141_RS10080	COG1321	iron dependent repressor
S100141_RS10085	COG0095	Lipoate-protein ligase
S100141_RS10090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100141_RS10095	COG2113	Glycine betaine
S100141_RS10100	COG4176	ABC-type proline glycine betaine transport system permease component
S100141_RS10105	COG4175	Glycine betaine
S100141_RS10105	COG0517	IMP dehydrogenase activity
S100141_RS10110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100141_RS10115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100141_RS10120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S100141_RS10125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100141_RS10150	COG0681	Belongs to the peptidase S26 family
S100141_RS10175	COG4940	Competence protein ComGF
S100141_RS10185	COG4970	Tfp pilus assembly protein FimT
S100141_RS10190	COG4537	Required for transformation and DNA binding
S100141_RS10195	COG1459	type II secretion system
S100141_RS10200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100141_RS10205	COG1366	Belongs to the anti-sigma-factor antagonist family
S100141_RS10215	COG1393	Belongs to the ArsC family
S100141_RS10225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS10235	COG0011	TIGRFAM Protein of
S100141_RS10245	COG2866	Carboxypeptidase
S100141_RS10250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS10255	COG1368	sulfuric ester hydrolase activity
S100141_RS10260	COG1940	carbohydrate kinase activity
S100141_RS10265	COG4483	Protein conserved in bacteria
S100141_RS10270	COG0697	spore germination
S100141_RS10275	COG0705	Rhomboid family
S100141_RS10275	COG0457	Tetratricopeptide repeat
S100141_RS10285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100141_RS10290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100141_RS10295	COG0438	transferase activity, transferring glycosyl groups
S100141_RS10310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100141_RS10315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100141_RS10320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100141_RS10325	COG0581	inorganic phosphate transmembrane transporter activity
S100141_RS10330	COG0573	inorganic phosphate transmembrane transporter activity
S100141_RS10335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100141_RS10340	COG0768	penicillin binding
S100141_RS10345	COG0477	Major facilitator Superfamily
S100141_RS10350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100141_RS10355	COG2839	Protein conserved in bacteria
S100141_RS10360	COG5521	maltodextrose utilization protein MalA
S100141_RS10365	COG1388	LysM domain
S100141_RS10370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S100141_RS10375	COG4709	membrane
S100141_RS10380	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S100141_RS10385	COG0735	belongs to the Fur family
S100141_RS10390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100141_RS10395	COG1121	(ABC) transporter
S100141_RS10400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS10410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100141_RS10415	COG0513	Belongs to the DEAD box helicase family
S100141_RS10425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S100141_RS10430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100141_RS10435	COG2384	SAM-dependent methyltransferase
S100141_RS10490	COG5444	nuclease activity
S100141_RS10505	COG2010	Cytochrome c
S100141_RS10510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100141_RS10515	COG0358	DNA primase activity
S100141_RS10520	COG1671	Belongs to the UPF0178 family
S100141_RS10525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100141_RS10530	COG0517	IMP dehydrogenase activity
S100141_RS10535	COG0751	glycine-tRNA ligase activity
S100141_RS10540	COG0752	glycyl-tRNA synthetase alpha subunit
S100141_RS10545	COG1381	Involved in DNA repair and RecF pathway recombination
S100141_RS10555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100141_RS10560	COG0295	cytidine deaminase activity
S100141_RS10565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100141_RS10570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100141_RS10575	COG1480	7TM receptor with intracellular HD hydrolase
S100141_RS10580	COG1702	phosphate starvation-inducible protein PhoH
S100141_RS10585	COG0561	phosphatase activity
S100141_RS10600	COG4864	UPF0365 protein
S100141_RS10605	COG1030	water channel activity
S100141_RS10610	COG1610	YqeY-like protein
S100141_RS10615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100141_RS10620	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100141_RS10625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100141_RS10630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100141_RS10635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100141_RS10640	COG2264	protein methyltransferase activity
S100141_RS10645	COG0484	heat shock protein binding
S100141_RS10650	COG0443	Heat shock 70 kDa protein
S100141_RS10655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100141_RS10660	COG1420	regulation of RNA biosynthetic process
S100141_RS10665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100141_RS10670	COG0481	GTPase activity
S100141_RS10680	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS10685	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S100141_RS10690	COG0268	Binds directly to 16S ribosomal RNA
S100141_RS10695	COG1466	dna polymerase III delta subunit
S100141_RS10705	COG0658	competence protein
S100141_RS10705	COG2333	competence protein COMEC
S100141_RS10710	COG2131	deaminase
S100141_RS10715	COG1555	photosystem II stabilization
S100141_RS10715	COG1596	polysaccharide export
S100141_RS10720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100141_RS10725	COG2226	methyltransferase
S100141_RS10730	COG0799	negative regulation of ribosome biogenesis
S100141_RS10735	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100141_RS10740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100141_RS10745	COG1534	Rna-binding protein
S100141_RS10750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100141_RS10755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100141_RS10760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100141_RS10770	COG2755	lipolytic protein G-D-S-L family
S100141_RS10775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS10780	COG5609	conserved protein (DUF2294)
S100141_RS10785	COG3383	formate dehydrogenase (NAD+) activity
S100141_RS10790	COG2427	Protein of unknown function (DUF1641)
S100141_RS10825	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS10870	COG1136	(ABC) transporter
S100141_RS10875	COG0577	efflux transmembrane transporter activity
S100141_RS10960	COG2197	response regulator
S100141_RS10965	COG4585	Histidine kinase
S100141_RS10970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS10975	COG0730	response to heat
S100141_RS10980	COG0425	Belongs to the sulfur carrier protein TusA family
S100141_RS10985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100141_RS10985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS10990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100141_RS10990	COG0425	Belongs to the sulfur carrier protein TusA family
S100141_RS10995	COG2210	Belongs to the sulfur carrier protein TusA family
S100141_RS11000	COG1937	Protein conserved in bacteria
S100141_RS11040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100141_RS11045	COG0113	porphobilinogen synthase activity
S100141_RS11050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S100141_RS11055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S100141_RS11060	COG1733	regulation of RNA biosynthetic process
S100141_RS11065	COG3239	Fatty acid desaturase
S100141_RS11070	COG4585	Histidine kinase
S100141_RS11075	COG2197	response regulator
S100141_RS11080	COG0492	ferredoxin-NADP+ reductase activity
S100141_RS11085	COG0747	negative chemotaxis
S100141_RS11090	COG0601	transmembrane transport
S100141_RS11095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS11100	COG0444	Belongs to the ABC transporter superfamily
S100141_RS11105	COG4608	Belongs to the ABC transporter superfamily
S100141_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS11140	COG2124	cytochrome p450
S100141_RS11145	COG0730	response to heat
S100141_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS11165	COG1621	beta-fructofuranosidase activity
S100141_RS11170	COG3716	PTS system mannose fructose sorbose family IID component
S100141_RS11175	COG3715	PTS system
S100141_RS11180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS11185	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS11215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100141_RS11220	COG0656	L-ascorbic acid biosynthetic process
S100141_RS11225	COG2814	Major facilitator Superfamily
S100141_RS11230	COG1733	regulation of RNA biosynthetic process
S100141_RS11235	COG3340	Belongs to the peptidase S51 family
S100141_RS11240	COG1587	Uroporphyrinogen-III synthase
S100141_RS11250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS11255	COG0583	DNA-binding transcription factor activity
S100141_RS11260	COG2814	Major facilitator Superfamily
S100141_RS11270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100141_RS11270	COG2124	cytochrome p450
S100141_RS11275	COG1309	transcriptional regulator
S100141_RS11280	COG1404	Belongs to the peptidase S8 family
S100141_RS11285	COG2226	methyltransferase
S100141_RS11310	COG0626	cystathionine gamma-synthase activity
S100141_RS11315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100141_RS11320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100141_RS11325	COG2226	methyltransferase
S100141_RS11340	COG0768	penicillin binding
S100141_RS11345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100141_RS11350	COG0572	uridine kinase
S100141_RS11355	COG0826	peptidase U32
S100141_RS11360	COG0826	peptidase U32
S100141_RS11365	COG4122	O-methyltransferase activity
S100141_RS11375	COG3906	Belongs to the UPF0473 family
S100141_RS11380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100141_RS11385	COG4472	Bacterial protein of unknown function (DUF965)
S100141_RS11390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100141_RS11395	COG0628	permease
S100141_RS11410	COG3881	PFAM PRC-barrel domain
S100141_RS11415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100141_RS11420	COG0457	Tetratricopeptide repeat
S100141_RS11425	COG0482	sulfurtransferase activity
S100141_RS11430	COG1104	cysteine desulfurase activity
S100141_RS11435	COG1959	2 iron, 2 sulfur cluster binding
S100141_RS11440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100141_RS11445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S100141_RS11455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100141_RS11460	COG0124	histidyl-tRNA synthetase
S100141_RS11470	COG4991	sh3 domain protein
S100141_RS11470	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS11470	COG3103	Sh3 type 3 domain protein
S100141_RS11475	COG1490	D-aminoacyl-tRNA deacylase activity
S100141_RS11480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100141_RS11485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100141_RS11490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100141_RS11490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100141_RS11495	COG5416	Lipopolysaccharide assembly protein A domain
S100141_RS11500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100141_RS11500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100141_RS11510	COG2244	polysaccharide biosynthetic process
S100141_RS11515	COG2323	membrane
S100141_RS11525	COG1862	Preprotein translocase
S100141_RS11530	COG0343	queuine tRNA-ribosyltransferase activity
S100141_RS11535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100141_RS11545	COG2255	four-way junction helicase activity
S100141_RS11550	COG0632	four-way junction helicase activity
S100141_RS11560	COG2112	serine threonine protein kinase
S100141_RS11570	COG2318	DinB family
S100141_RS11575	COG4195	phage-related replication protein
S100141_RS11590	COG0217	transcriptional regulatory protein
S100141_RS11600	COG1388	LysM domain
S100141_RS11605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S100141_RS11610	COG0157	Belongs to the NadC ModD family
S100141_RS11615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S100141_RS11620	COG1104	cysteine desulfurase activity
S100141_RS11625	COG1827	regulation of RNA biosynthetic process
S100141_RS11630	COG0077	Prephenate dehydratase
S100141_RS11635	COG4492	Belongs to the UPF0735 family
S100141_RS11640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100141_RS11645	COG3290	protein histidine kinase activity
S100141_RS11650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100141_RS11655	COG2868	ribosomal protein
S100141_RS11660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100141_RS11665	COG1994	Peptidase M50
S100141_RS11670	COG0739	heme binding
S100141_RS11675	COG3832	glyoxalase III activity
S100141_RS11680	COG0640	Transcriptional regulator
S100141_RS11685	COG2894	cell division
S100141_RS11690	COG0850	regulation of cytokinetic process
S100141_RS11695	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S100141_RS11705	COG1077	Cell shape determining protein MreB Mrl
S100141_RS11710	COG2003	Belongs to the UPF0758 family
S100141_RS11725	COG0457	Tetratricopeptide repeat
S100141_RS11730	COG5444	nuclease activity
S100141_RS11775	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100141_RS11840	COG1802	Transcriptional regulator
S100141_RS11840	COG4626	Terminase
S100141_RS11960	COG2003	Belongs to the UPF0758 family
S100141_RS11965	COG0424	maF-like protein
S100141_RS11975	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100141_RS11980	COG0285	dihydrofolate synthase activity
S100141_RS11985	COG0525	valine-tRNA ligase activity
S100141_RS11995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100141_RS12000	COG1388	LysM domain
S100141_RS12005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100141_RS12010	COG0113	porphobilinogen synthase activity
S100141_RS12015	COG1587	Uroporphyrinogen-III synthase
S100141_RS12020	COG0181	hydroxymethylbilane synthase activity
S100141_RS12025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100141_RS12030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S100141_RS12040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100141_RS12045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100141_RS12050	COG0470	DNA polymerase III
S100141_RS12050	COG1067	ATP-dependent peptidase activity
S100141_RS12055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100141_RS12060	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100141_RS12065	COG1477	protein flavinylation
S100141_RS12065	COG0457	Tetratricopeptide repeat
S100141_RS12070	COG0066	3-isopropylmalate dehydratase activity
S100141_RS12075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S100141_RS12080	COG0473	3-isopropylmalate dehydrogenase activity
S100141_RS12085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100141_RS12090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S100141_RS12095	COG0440	acetolactate synthase activity
S100141_RS12100	COG0028	Belongs to the TPP enzyme family
S100141_RS12105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100141_RS12115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100141_RS12135	COG5518	Phage portal protein
S100141_RS12140	COG1783	phage Terminase large subunit
S100141_RS12175	COG5444	nuclease activity
S100141_RS12180	COG0457	Tetratricopeptide repeat
S100141_RS12200	COG0622	Phosphoesterase
S100141_RS12205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100141_RS12210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S100141_RS12215	COG5401	PFAM Sporulation and spore germination
S100141_RS12220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100141_RS12225	COG1846	Transcriptional regulator
S100141_RS12230	COG2197	response regulator
S100141_RS12235	COG4221	oxidoreductase activity
S100141_RS12240	COG0824	Thioesterase
S100141_RS12245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S100141_RS12250	COG1053	succinate dehydrogenase
S100141_RS12255	COG2009	succinate dehydrogenase
S100141_RS12260	COG1719	4-vinyl reductase, 4VR
S100141_RS12265	COG0527	aspartate kinase activity
S100141_RS12270	COG0322	excinuclease ABC activity
S100141_RS12275	COG3118	belongs to the thioredoxin family
S100141_RS12280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100141_RS12285	COG2086	electron transfer activity
S100141_RS12290	COG1024	Enoyl-CoA hydratase
S100141_RS12295	COG1309	transcriptional regulator
S100141_RS12300	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS12305	COG3766	membrane
S100141_RS12310	COG1193	negative regulation of DNA recombination
S100141_RS12315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100141_RS12315	COG1796	DNA polymerase
S100141_RS12320	COG1286	toxin biosynthetic process
S100141_RS12325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S100141_RS12330	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100141_RS12360	COG1137	ATPase activity
S100141_RS12375	COG0072	phenylalanine-tRNA ligase activity
S100141_RS12375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100141_RS12380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100141_RS12385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100141_RS12410	COG0395	ABC-type sugar transport system, permease component
S100141_RS12415	COG1175	transmembrane transport
S100141_RS12420	COG1653	transport
S100141_RS12425	COG0371	Dehydrogenase
S100141_RS12430	COG0235	Class ii aldolase
S100141_RS12435	COG1069	ribulokinase activity
S100141_RS12440	COG2160	L-arabinose isomerase activity
S100141_RS12445	COG3507	Belongs to the glycosyl hydrolase 43 family
S100141_RS12450	COG1363	Peptidase, m42
S100141_RS12460	COG3326	Membrane
S100141_RS12465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100141_RS12470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100141_RS12475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100141_RS12480	COG1346	cytolysis
S100141_RS12490	COG3540	Alkaline phosphatase
S100141_RS12495	COG3279	Response regulator of the LytR AlgR family
S100141_RS12500	COG3275	phosphorelay sensor kinase activity
S100141_RS12510	COG1011	Hydrolase
S100141_RS12515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100141_RS12525	COG0398	Pfam SNARE associated Golgi protein
S100141_RS12535	COG3611	Membrane attachment protein
S100141_RS12540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100141_RS12555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S100141_RS12560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100141_RS12565	COG3866	Pectate lyase
S100141_RS12570	COG0237	dephospho-CoA kinase activity
S100141_RS12575	COG1971	Probably functions as a manganese efflux pump
S100141_RS12580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100141_RS12585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100141_RS12585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100141_RS12590	COG5002	protein histidine kinase activity
S100141_RS12595	COG0745	RESPONSE REGULATOR receiver
S100141_RS12600	COG0039	L-malate dehydrogenase activity
S100141_RS12605	COG0538	isocitrate dehydrogenase activity
S100141_RS12610	COG0372	Belongs to the citrate synthase family
S100141_RS12615	COG2707	UPF0756 membrane protein
S100141_RS12620	COG0628	permease
S100141_RS12625	COG3030	protein affecting phage T7 exclusion by the F plasmid
S100141_RS12635	COG0205	6-phosphofructokinase activity
S100141_RS12640	COG0825	malonyl-CoA metabolic process
S100141_RS12645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100141_RS12650	COG0281	malic enzyme
S100141_RS12655	COG0587	DNA-directed DNA polymerase activity
S100141_RS12675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100141_RS12685	COG4109	DRTGG domain
S100141_RS12690	COG1695	Transcriptional regulator
S100141_RS12695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100141_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS12710	COG0137	argininosuccinate synthase activity
S100141_RS12715	COG0521	Mo-molybdopterin cofactor biosynthetic process
S100141_RS12720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100141_RS12725	COG0827	DNA restriction-modification system
S100141_RS12730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S100141_RS12735	COG3874	Sporulation protein YtfJ
S100141_RS12745	COG1714	RDD family
S100141_RS12750	COG0616	signal peptide processing
S100141_RS12755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100141_RS12760	COG1566	PFAM secretion protein HlyD family protein
S100141_RS12765	COG0477	Major facilitator Superfamily
S100141_RS12775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100141_RS12785	COG0301	tRNA thio-modification
S100141_RS12790	COG1104	cysteine desulfurase activity
S100141_RS12795	COG1114	Component of the transport system for branched-chain amino acids
S100141_RS12805	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100141_RS12810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100141_RS12815	COG1309	transcriptional regulator
S100141_RS12820	COG1956	GAF domain-containing protein
S100141_RS12825	COG2199	diguanylate cyclase activity
S100141_RS12825	COG2203	Gaf domain
S100141_RS12835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100141_RS12850	COG3152	Membrane
S100141_RS12855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100141_RS12860	COG1522	sequence-specific DNA binding
S100141_RS12865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100141_RS12870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100141_RS12875	COG0454	-acetyltransferase
S100141_RS12880	COG0517	IMP dehydrogenase activity
S100141_RS12885	COG0123	including yeast histone deacetylase and acetoin utilization protein
S100141_RS12890	COG1360	Flagellar Motor Protein
S100141_RS12895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100141_RS12900	COG1609	Transcriptional regulator
S100141_RS12905	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100141_RS12905	COG1605	Chorismate mutase
S100141_RS12915	COG3118	belongs to the thioredoxin family
S100141_RS12920	COG4980	gas vesicle protein
S100141_RS12925	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100141_RS12930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100141_RS12935	COG1674	ftsk spoiiie
S100141_RS12940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100141_RS12945	COG4848	Belongs to the UPF0354 family
S100141_RS12950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS12960	COG1363	Peptidase, m42
S100141_RS12965	COG5584	Small secreted protein
S100141_RS12970	COG0281	malic enzyme
S100141_RS12975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS12980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100141_RS12990	COG0510	thiamine kinase activity
S100141_RS13000	COG1597	lipid kinase activity
S100141_RS13010	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100141_RS13015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100141_RS13030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100141_RS13035	COG2252	PERMEase
S100141_RS13040	COG1349	DNA-binding transcription factor activity
S100141_RS13045	COG1187	pseudouridine synthase activity
S100141_RS13050	COG2244	polysaccharide biosynthetic process
S100141_RS13055	COG2081	HI0933 family
S100141_RS13060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S100141_RS13070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100141_RS13075	COG0457	Tetratricopeptide repeat
S100141_RS13085	COG5578	integral membrane protein
S100141_RS13090	COG0673	inositol 2-dehydrogenase activity
S100141_RS13095	COG1653	transport
S100141_RS13100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100141_RS13105	COG4209	transmembrane transport
S100141_RS13110	COG2207	Transcriptional regulator
S100141_RS13120	COG1653	transport
S100141_RS13125	COG0395	ABC-type sugar transport system, permease component
S100141_RS13130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100141_RS13135	COG1073	alpha beta
S100141_RS13145	COG0583	DNA-binding transcription factor activity
S100141_RS13150	COG0346	lactoylglutathione lyase activity
S100141_RS13155	COG0495	leucyl-tRNA aminoacylation
S100141_RS13165	COG2814	Major facilitator Superfamily
S100141_RS13175	COG2433	Pfam Transposase IS66
S100141_RS13180	COG0577	efflux transmembrane transporter activity
S100141_RS13185	COG1136	(ABC) transporter
S100141_RS13195	COG1131	(ABC) transporter
S100141_RS13200	COG1725	Transcriptional regulator
S100141_RS13210	COG1242	4 iron, 4 sulfur cluster binding
S100141_RS13215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100141_RS13220	COG1301	dicarboxylic acid transport
S100141_RS13230	COG2267	carboxylic ester hydrolase activity
S100141_RS13235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100141_RS13240	COG0671	phosphoesterase, PA-phosphatase related
S100141_RS13245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100141_RS13245	COG0438	transferase activity, transferring glycosyl groups
S100141_RS13250	COG0367	asparagine synthase
S100141_RS13255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100141_RS13260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S100141_RS13275	COG1506	peptidase
S100141_RS13280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100141_RS13285	COG1116	anion transmembrane transporter activity
S100141_RS13290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100141_RS13295	COG0494	nUDIX hydrolase
S100141_RS13305	COG4824	toxin secretion phage lysis holin
S100141_RS13310	COG0783	Belongs to the Dps family
S100141_RS13325	COG1854	S-ribosylhomocysteine lyase activity
S100141_RS13330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100141_RS13335	COG0288	reversible hydration of carbon dioxide
S100141_RS13340	COG0523	cobalamin synthesis protein
S100141_RS13345	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100141_RS13350	COG0254	rRNA binding
S100141_RS13355	COG1271	oxidase subunit
S100141_RS13360	COG1294	oxidase, subunit
S100141_RS13375	COG4948	Mandelate Racemase Muconate Lactonizing
S100141_RS13380	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS13385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S100141_RS13390	COG0596	Alpha beta hydrolase
S100141_RS13395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S100141_RS13400	COG1169	isochorismate synthase
S100141_RS13405	COG1575	Belongs to the MenA family. Type 1 subfamily
S100141_RS13410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100141_RS13420	COG0297	glycogen (starch) synthase activity
S100141_RS13425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100141_RS13430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100141_RS13435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100141_RS13565	COG3859	Proton-coupled thiamine transporter YuaJ
S100141_RS13570	COG3764	Sortase (surface protein transpeptidase)
S100141_RS13585	COG0457	Tetratricopeptide repeat
S100141_RS13590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S100141_RS13595	COG0569	domain protein
S100141_RS13600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100141_RS13610	COG2318	DinB family
S100141_RS13620	COG1454	alcohol dehydrogenase
S100141_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS13630	COG1510	regulation of RNA biosynthetic process
S100141_RS13640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S100141_RS13645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100141_RS13650	COG2140	Oxalate decarboxylase
S100141_RS13710	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S100141_RS13720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100141_RS13725	COG0726	polysaccharide deacetylase
S100141_RS13730	COG1408	metallophosphoesterase
S100141_RS13735	COG1968	undecaprenyl-diphosphatase activity
S100141_RS13740	COG0628	permease
S100141_RS13745	COG0673	inositol 2-dehydrogenase activity
S100141_RS13750	COG0693	protein deglycase activity
S100141_RS13755	COG0840	transmembrane signaling receptor activity
S100141_RS13760	COG0840	transmembrane signaling receptor activity
S100141_RS13775	COG2070	2-Nitropropane dioxygenase
S100141_RS13780	COG0432	Pfam Uncharacterised protein family UPF0047
S100141_RS13785	COG0366	Alpha amylase catalytic
S100141_RS13800	COG5297	Belongs to the glycosyl hydrolase family 6
S100141_RS13805	COG1253	flavin adenine dinucleotide binding
S100141_RS13810	COG2738	Putative neutral zinc metallopeptidase
S100141_RS13825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100141_RS13840	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100141_RS13885	COG5444	nuclease activity
S100141_RS13925	COG5434	Belongs to the glycosyl hydrolase 28 family
S100141_RS13930	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100141_RS13940	COG5280	Phage tail tape measure protein TP901
S100141_RS13940	COG3953	SLT domain
S100141_RS14000	COG4626	Terminase
S100141_RS14000	COG1802	Transcriptional regulator
S100141_RS14120	COG0166	Belongs to the GPI family
S100141_RS14125	COG1979	alcohol dehydrogenase
S100141_RS14130	COG2155	Conserved Protein
S100141_RS14135	COG1098	S1 RNA binding domain
S100141_RS14140	COG0436	Aminotransferase
S100141_RS14145	COG1522	sequence-specific DNA binding
S100141_RS14150	COG2267	carboxylic ester hydrolase activity
S100141_RS14165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100141_RS14180	COG5018	Exonuclease
S100141_RS14185	COG2814	Major facilitator Superfamily
S100141_RS14190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100141_RS14195	COG3011	Protein conserved in bacteria
S100141_RS14210	COG4565	transcriptional regulatory protein
S100141_RS14220	COG1183	phosphatidylcholine synthase activity
S100141_RS14225	COG0586	Pfam SNARE associated Golgi protein
S100141_RS14235	COG3493	citrate carrier protein
S100141_RS14245	COG2111	Na H antiporter
S100141_RS14245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100141_RS14250	COG2111	Na H antiporter
S100141_RS14255	COG1006	Multisubunit Na H antiporter MnhC subunit
S100141_RS14260	COG0651	ATP synthesis coupled electron transport
S100141_RS14265	COG1863	multisubunit Na H antiporter MnhE subunit
S100141_RS14270	COG2212	antiporter activity
S100141_RS14275	COG1320	monovalent cation:proton antiporter activity
S100141_RS14280	COG2050	protein possibly involved in aromatic compounds catabolism
S100141_RS14285	COG2197	response regulator
S100141_RS14290	COG4585	Histidine kinase
S100141_RS14320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100141_RS14325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100141_RS14330	COG1335	isochorismatase
S100141_RS14335	COG5506	Protein of unknown function (DUF1694)
S100141_RS14350	COG0628	permease
S100141_RS14355	COG1959	2 iron, 2 sulfur cluster binding
S100141_RS14370	COG1418	mRNA catabolic process
S100141_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS14385	COG1511	domain protein
S100141_RS14390	COG1674	ftsk spoiiie
S100141_RS14390	COG0433	COG0433 Predicted ATPase
S100141_RS14395	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100141_RS14400	COG5417	Belongs to the EsaB family
S100141_RS14405	COG4842	Belongs to the WXG100 family
S100141_RS14410	COG1115	amino acid carrier protein
S100141_RS14415	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100141_RS14415	COG2508	Transcriptional regulator
S100141_RS14420	COG0686	Belongs to the AlaDH PNT family
S100141_RS14430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100141_RS14435	COG1268	BioY protein
S100141_RS14440	COG2056	Na+-H+ antiporter family
S100141_RS14445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S100141_RS14450	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100141_RS14455	COG3584	3D domain protein
S100141_RS14465	COG1252	NADH dehydrogenase
S100141_RS14470	COG0492	ferredoxin-NADP+ reductase activity
S100141_RS14485	COG0456	acetyltransferase
S100141_RS14490	COG0316	Belongs to the HesB IscA family
S100141_RS14495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100141_RS14500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100141_RS14505	COG4844	belongs to the
S100141_RS14510	COG1252	NADH dehydrogenase
S100141_RS14515	COG5646	InterPro IPR014922
S100141_RS14525	COG0457	Tetratricopeptide repeat
S100141_RS14530	COG3479	Phenolic acid decarboxylase
S100141_RS14540	COG4837	Protein of unknown function (DUF1462)
S100141_RS14545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100141_RS14550	COG1506	peptidase
S100141_RS14550	COG0823	Involved in the tonB-independent uptake of proteins
S100141_RS14550	COG4946	Tricorn protease homolog
S100141_RS14555	COG0083	homoserine kinase activity
S100141_RS14560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100141_RS14565	COG0460	homoserine dehydrogenase
S100141_RS14575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100141_RS14580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100141_RS14585	COG0647	UMP catabolic process
S100141_RS14590	COG2445	Protein of unknown function DUF86
S100141_RS14595	COG4470	Protein conserved in bacteria
S100141_RS14610	COG0739	heme binding
S100141_RS14620	COG0733	neurotransmitter:sodium symporter activity
S100141_RS14630	COG3377	Domain of unknown function (DUF1805)
S100141_RS14635	COG0737	Belongs to the 5'-nucleotidase family
S100141_RS14640	COG0730	response to heat
S100141_RS14645	COG1801	Protein of unknown function DUF72
S100141_RS14655	COG3226	Transcriptional regulator
S100141_RS14665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100141_RS14670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100141_RS14675	COG2508	Transcriptional regulator
S100141_RS14680	COG2814	Major facilitator Superfamily
S100141_RS14685	COG1288	antiporter activity
S100141_RS14695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100141_RS14700	COG2356	endonuclease I
S100141_RS14710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100141_RS14725	COG0457	Tetratricopeptide repeat
S100141_RS14730	COG0719	Fe-S assembly protein
S100141_RS14735	COG0822	iron-sulfur transferase activity
S100141_RS14740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100141_RS14745	COG0719	Fe-S assembly protein
S100141_RS14750	COG0396	ATPase activity
S100141_RS14760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100141_RS14765	COG1464	Belongs to the NlpA lipoprotein family
S100141_RS14770	COG2011	ABC-type metal ion transport system permease component
S100141_RS14775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100141_RS14785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS14790	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100141_RS14800	COG0509	glycine decarboxylation via glycine cleavage system
S100141_RS14805	COG1393	Belongs to the ArsC family
S100141_RS14810	COG1960	acyl-CoA dehydrogenase activity
S100141_RS14815	COG0183	Belongs to the thiolase family
S100141_RS14820	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100141_RS14820	COG1024	Enoyl-CoA hydratase
S100141_RS14835	COG5577	PFAM Coat F domain
S100141_RS14850	COG1120	ATPase activity
S100141_RS14855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS14860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS14865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS14880	COG1686	Belongs to the peptidase S11 family
S100141_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS14890	COG0783	Belongs to the Dps family
S100141_RS14895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100141_RS14900	COG0745	RESPONSE REGULATOR receiver
S100141_RS14905	COG2770	Histidine kinase
S100141_RS14905	COG2205	protein histidine kinase activity
S100141_RS14915	COG1309	transcriptional regulator
S100141_RS14920	COG0114	fumarate hydratase activity
S100141_RS14935	COG0814	amino acid
S100141_RS14950	COG2197	response regulator
S100141_RS14955	COG4585	Histidine kinase
S100141_RS14960	COG4758	membrane
S100141_RS14970	COG1842	Phage shock protein A
S100141_RS14975	COG4758	membrane
S100141_RS14980	COG4677	pectinesterase activity
S100141_RS14985	COG2096	Adenosyltransferase
S100141_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS15000	COG1454	alcohol dehydrogenase
S100141_RS15005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100141_RS15010	COG1120	ATPase activity
S100141_RS15015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS15020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS15025	COG1802	Transcriptional regulator
S100141_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS15035	COG2258	MOSC domain
S100141_RS15040	COG0583	DNA-binding transcription factor activity
S100141_RS15050	COG2721	sulfolactate sulfo-lyase activity
S100141_RS15055	COG0246	Mannitol dehydrogenase
S100141_RS15060	COG1609	Transcriptional regulator
S100141_RS15065	COG2211	Major facilitator Superfamily
S100141_RS15070	COG1904	glucuronate isomerase
S100141_RS15075	COG2205	protein histidine kinase activity
S100141_RS15080	COG0745	RESPONSE REGULATOR receiver
S100141_RS15085	COG1120	ATPase activity
S100141_RS15090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS15095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS15100	COG0531	amino acid
S100141_RS15110	COG1988	membrane-bound metal-dependent
S100141_RS15115	COG1368	sulfuric ester hydrolase activity
S100141_RS15120	COG2814	Major facilitator Superfamily
S100141_RS15125	COG0656	L-ascorbic acid biosynthetic process
S100141_RS15130	COG1940	carbohydrate kinase activity
S100141_RS15135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100141_RS15145	COG3973	AAA domain
S100141_RS15150	COG2860	membrane
S100141_RS15155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100141_RS15155	COG0456	acetyltransferase
S100141_RS15160	COG0456	acetyltransferase
S100141_RS15165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S100141_RS15170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S100141_RS15175	COG2217	Heavy metal translocating P-type atpase
S100141_RS15180	COG1653	transport
S100141_RS15185	COG1175	transmembrane transport
S100141_RS15190	COG0395	ABC-type sugar transport system, permease component
S100141_RS15195	COG1501	Belongs to the glycosyl hydrolase 31 family
S100141_RS15200	COG1472	Belongs to the glycosyl hydrolase 3 family
S100141_RS15205	COG1121	(ABC) transporter
S100141_RS15210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100141_RS15215	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100141_RS15230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100141_RS15230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S100141_RS15235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS15235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100141_RS15235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS15250	COG2217	Heavy metal translocating P-type atpase
S100141_RS15255	COG2608	mercury ion transmembrane transporter activity
S100141_RS15260	COG1937	Protein conserved in bacteria
S100141_RS15265	COG0693	protein deglycase activity
S100141_RS15270	COG1349	DNA-binding transcription factor activity
S100141_RS15275	COG1070	Carbohydrate kinase
S100141_RS15280	COG4952	isomerase
S100141_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS15290	COG3347	Dehydrogenase
S100141_RS15295	COG2814	Major facilitator Superfamily
S100141_RS15300	COG2814	Major facilitator Superfamily
S100141_RS15310	COG2124	cytochrome p450
S100141_RS15320	COG1846	Transcriptional regulator
S100141_RS15330	COG0673	inositol 2-dehydrogenase activity
S100141_RS15335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100141_RS15340	COG1054	Belongs to the UPF0176 family
S100141_RS15350	COG1191	sigma factor activity
S100141_RS15360	COG2140	Oxalate decarboxylase
S100141_RS15390	COG5444	nuclease activity
S100141_RS15410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100141_RS15415	COG0557	exoribonuclease II activity
S100141_RS15420	COG1647	Serine aminopeptidase, S33
S100141_RS15425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100141_RS15430	COG2002	toxin-antitoxin pair type II binding
S100141_RS15435	COG1476	TRANSCRIPTIONal
S100141_RS15440	COG1396	sequence-specific DNA binding
S100141_RS15445	COG1396	sequence-specific DNA binding
S100141_RS15450	COG1174	glycine betaine transport
S100141_RS15455	COG1732	Glycine betaine
S100141_RS15460	COG1174	glycine betaine transport
S100141_RS15465	COG0517	IMP dehydrogenase activity
S100141_RS15465	COG1125	glycine betaine transport
S100141_RS15470	COG1510	regulation of RNA biosynthetic process
S100141_RS15475	COG2095	MarC family integral membrane protein
S100141_RS15480	COG3064	Membrane
S100141_RS15490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS15500	COG0693	protein deglycase activity
S100141_RS15505	COG0148	phosphopyruvate hydratase activity
S100141_RS15510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S100141_RS15515	COG0149	triose-phosphate isomerase activity
S100141_RS15520	COG0126	phosphoglycerate kinase activity
S100141_RS15525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100141_RS15530	COG2390	Transcriptional regulator
S100141_RS15535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100141_RS15540	COG1113	amino acid transport
S100141_RS15550	COG1131	(ABC) transporter
S100141_RS15560	COG1556	Lactate utilization protein
S100141_RS15565	COG1139	Iron-sulfur cluster binding protein
S100141_RS15570	COG0247	lactate metabolic process
S100141_RS15575	COG2186	Transcriptional regulator
S100141_RS15580	COG1620	l-lactate permease
S100141_RS15585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100141_RS15595	COG5039	Polysaccharide pyruvyl transferase
S100141_RS15600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100141_RS15605	COG0110	maltose O-acetyltransferase activity
S100141_RS15610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100141_RS15615	COG2244	polysaccharide biosynthetic process
S100141_RS15620	COG1216	Glycosyl transferase, family 2
S100141_RS15625	COG5039	Polysaccharide pyruvyl transferase
S100141_RS15630	COG1216	Glycosyl transferase, family 2
S100141_RS15640	COG0438	transferase activity, transferring glycosyl groups
S100141_RS15645	COG1215	transferase activity, transferring glycosyl groups
S100141_RS15650	COG0438	transferase activity, transferring glycosyl groups
S100141_RS15655	COG1086	Polysaccharide biosynthesis protein
S100141_RS15660	COG0489	protein tyrosine kinase activity
S100141_RS15665	COG3944	biosynthesis protein
S100141_RS15670	COG1396	sequence-specific DNA binding
S100141_RS15675	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100141_RS15680	COG2271	Major facilitator Superfamily
S100141_RS15690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S100141_RS15705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100141_RS15715	COG1733	regulation of RNA biosynthetic process
S100141_RS15720	COG1902	pentaerythritol trinitrate reductase activity
S100141_RS15725	COG1621	beta-fructofuranosidase activity
S100141_RS15730	COG1621	beta-fructofuranosidase activity
S100141_RS15745	COG0740	serine-type endopeptidase activity
S100141_RS15750	COG1611	Belongs to the LOG family
S100141_RS15755	COG1694	Mazg nucleotide pyrophosphohydrolase
S100141_RS15760	COG1078	dGTPase activity
S100141_RS15765	COG0659	secondary active sulfate transmembrane transporter activity
S100141_RS15770	COG0288	reversible hydration of carbon dioxide
S100141_RS15775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100141_RS15780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100141_RS15785	COG0640	Transcriptional regulator
S100141_RS15795	COG2732	(Barnase) inhibitor
S100141_RS15800	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S100141_RS15805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS15810	COG1481	regulation of sporulation
S100141_RS15815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100141_RS15820	COG1660	Displays ATPase and GTPase activities
S100141_RS15825	COG1051	belongs to the nudix hydrolase family
S100141_RS15835	COG0492	ferredoxin-NADP+ reductase activity
S100141_RS15840	COG0457	Tetratricopeptide repeat
S100141_RS15845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS15850	COG0140	phosphoribosyl-ATP diphosphatase activity
S100141_RS15850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100141_RS15855	COG0107	imidazoleglycerol-phosphate synthase activity
S100141_RS15860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100141_RS15865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100141_RS15870	COG0131	Imidazoleglycerol-phosphate dehydratase
S100141_RS15875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100141_RS15880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100141_RS15885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100141_RS15890	COG4990	cell redox homeostasis
S100141_RS15895	COG5297	Belongs to the glycosyl hydrolase family 6
S100141_RS15900	COG0110	maltose O-acetyltransferase activity
S100141_RS15905	COG0546	phosphoglycolate phosphatase activity
S100141_RS15910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S100141_RS15915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100141_RS15920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100141_RS15925	COG1846	Transcriptional regulator
S100141_RS15930	COG2814	Major facilitator Superfamily
S100141_RS15935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100141_RS15940	COG1950	PFAM Membrane protein of
S100141_RS15945	COG1983	PspC domain protein
S100141_RS15950	COG3595	metallopeptidase activity
S100141_RS15975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100141_RS15980	COG0556	nucleotide-excision repair
S100141_RS15985	COG4897	Protein conserved in bacteria
S100141_RS15995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100141_RS16005	COG0793	Belongs to the peptidase S41A family
S100141_RS16005	COG3409	Peptidoglycan-binding domain 1 protein
S100141_RS16010	COG0473	3-isopropylmalate dehydrogenase activity
S100141_RS16015	COG3883	PFAM NLP P60 protein
S100141_RS16015	COG0791	NLP P60 protein
S100141_RS16020	COG2177	Part of the ABC transporter FtsEX involved in
S100141_RS16025	COG2884	Cell division ATP-binding protein ftsE
S100141_RS16035	COG2010	Cytochrome c
S100141_RS16040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS16050	COG0653	protein targeting
S100141_RS16055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S100141_RS16070	COG1516	flagellar protein fliS
S100141_RS16075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S100141_RS16080	COG1334	flagellar protein FlaG
S100141_RS16085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100141_RS16090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S100141_RS16095	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S100141_RS16105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100141_RS16110	COG4786	Flagellar basal body rod
S100141_RS16110	COG1256	bacterial-type flagellum assembly
S100141_RS16115	COG3418	PFAM FlgN family protein
S100141_RS16120	COG2747	anti-sigma28 factor FlgM
S100141_RS16130	COG1040	competence protein
S100141_RS16140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100141_RS16145	COG1307	EDD domain protein, DegV family
S100141_RS16150	COG2197	response regulator
S100141_RS16155	COG4585	Histidine kinase
S100141_RS16160	COG1739	Uncharacterized protein family UPF0029
S100141_RS16165	COG1316	TRANSCRIPTIONal
S100141_RS16175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100141_RS16180	COG0438	transferase activity, transferring glycosyl groups
S100141_RS16185	COG1215	transferase activity, transferring glycosyl groups
S100141_RS16190	COG3206	protein involved in exopolysaccharide biosynthesis
S100141_RS16195	COG3307	-O-antigen
S100141_RS16200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100141_RS16205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100141_RS16210	COG0297	glycogen (starch) synthase activity
S100141_RS16210	COG0438	transferase activity, transferring glycosyl groups
S100141_RS16215	COG2244	polysaccharide biosynthetic process
S100141_RS16225	COG2247	cell wall binding repeat
S100141_RS16225	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS16230	COG2385	sporulation resulting in formation of a cellular spore
S100141_RS16230	COG2247	cell wall binding repeat
S100141_RS16240	COG1316	TRANSCRIPTIONal
S100141_RS16250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100141_RS16255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100141_RS16260	COG1134	teichoic acid transport
S100141_RS16265	COG1682	transport, permease protein
S100141_RS16280	COG0463	Glycosyl transferase, family 2
S100141_RS16280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100141_RS16285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100141_RS16290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100141_RS16295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100141_RS16300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100141_RS16305	COG4193	domain, Protein
S100141_RS16310	COG1482	cell wall glycoprotein biosynthetic process
S100141_RS16330	COG0800	Aldolase
S100141_RS16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100141_RS16340	COG1609	Transcriptional regulator
S100141_RS16345	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S100141_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS16355	COG1063	alcohol dehydrogenase
S100141_RS16365	COG1316	TRANSCRIPTIONal
S100141_RS16370	COG0561	phosphatase activity
S100141_RS16375	COG0791	NLP P60 protein
S100141_RS16385	COG2843	Capsule synthesis protein
S100141_RS16395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100141_RS16400	COG1609	Transcriptional regulator
S100141_RS16405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100141_RS16410	COG1869	D-ribose catabolic process
S100141_RS16415	COG1129	ABC transporter
S100141_RS16420	COG1172	Belongs to the binding-protein-dependent transport system permease family
S100141_RS16425	COG1879	ABC-type sugar transport system periplasmic component
S100141_RS16435	COG3527	Alpha-acetolactate decarboxylase
S100141_RS16440	COG0028	Belongs to the TPP enzyme family
S100141_RS16445	COG0583	DNA-binding transcription factor activity
S100141_RS16450	COG0405	Gamma-glutamyltransferase
S100141_RS16455	COG1522	sequence-specific DNA binding
S100141_RS16460	COG2059	Chromate
S100141_RS16465	COG2059	Chromate
S100141_RS16470	COG4464	protein tyrosine phosphatase activity
S100141_RS16475	COG3944	biosynthesis protein
S100141_RS16485	COG4715	Zinc finger, swim domain protein
S100141_RS16490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100141_RS16495	COG0561	phosphatase activity
S100141_RS16500	COG1349	DNA-binding transcription factor activity
S100141_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS16520	COG3732	PTS system glucitol sorbitol-specific
S100141_RS16540	COG0629	single-stranded DNA binding
S100141_RS16555	COG1970	mechanosensitive ion channel activity
S100141_RS16560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100141_RS16565	COG4786	Flagellar basal body rod
S100141_RS16570	COG4786	Flagellar basal body rod
S100141_RS16575	COG1077	Cell shape determining protein MreB Mrl
S100141_RS16580	COG1609	Transcriptional regulator
S100141_RS16590	COG1846	Transcriptional regulator
S100141_RS16595	COG2814	Major facilitator Superfamily
S100141_RS16600	COG0671	phosphoesterase, PA-phosphatase related
S100141_RS16605	COG1227	inorganic diphosphatase activity
S100141_RS16610	COG3546	catalase activity
S100141_RS16615	COG3361	conserved protein (COG2071)
S100141_RS16625	COG0598	Magnesium transport protein CorA
S100141_RS16630	COG1253	flavin adenine dinucleotide binding
S100141_RS16635	COG0004	ammonium transporteR
S100141_RS16640	COG0347	Belongs to the P(II) protein family
S100141_RS16645	COG0740	serine-type endopeptidase activity
S100141_RS16655	COG0739	heme binding
S100141_RS16660	COG1247	-acetyltransferase
S100141_RS16670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100141_RS16680	COG0477	Major facilitator Superfamily
S100141_RS16685	COG3251	PFAM MbtH domain protein
S100141_RS16690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS16695	COG1535	isochorismatase
S100141_RS16695	COG3433	isochorismatase activity
S100141_RS16700	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100141_RS16705	COG1169	isochorismate synthase
S100141_RS16710	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS16715	COG2819	hydrolase of the alpha beta superfamily
S100141_RS16720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS16725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS16730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS16735	COG2207	Transcriptional regulator
S100141_RS16735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100141_RS16745	COG2910	NAD(P)H-binding
S100141_RS16750	COG1959	2 iron, 2 sulfur cluster binding
S100141_RS16755	COG1994	Peptidase M50
S100141_RS16760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100141_RS16765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S100141_RS16770	COG2223	nitrite transmembrane transporter activity
S100141_RS16775	COG3383	formate dehydrogenase (NAD+) activity
S100141_RS16780	COG2304	oxidoreductase activity
S100141_RS16785	COG2304	oxidoreductase activity
S100141_RS16790	COG2385	sporulation resulting in formation of a cellular spore
S100141_RS16795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100141_RS16805	COG4836	Membrane
S100141_RS16810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100141_RS16815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100141_RS16820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100141_RS16825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100141_RS16830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100141_RS16835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100141_RS16840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100141_RS16860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100141_RS16865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100141_RS16870	COG4475	Protein of unknown function (DUF436)
S100141_RS16875	COG0698	ribose 5-phosphate isomerase
S100141_RS16880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100141_RS16885	COG1971	Probably functions as a manganese efflux pump
S100141_RS16890	COG0009	L-threonylcarbamoyladenylate synthase
S100141_RS16895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S100141_RS16905	COG0738	Major facilitator superfamily
S100141_RS16910	COG0673	inositol 2-dehydrogenase activity
S100141_RS16915	COG0561	phosphatase activity
S100141_RS16920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100141_RS16925	COG1609	Transcriptional regulator
S100141_RS16930	COG2890	protein-(glutamine-N5) methyltransferase activity
S100141_RS16935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100141_RS16940	COG0346	lactoylglutathione lyase activity
S100141_RS16945	COG0789	Transcriptional regulator
S100141_RS16950	COG0679	Auxin Efflux Carrier
S100141_RS16955	COG0281	malic enzyme
S100141_RS16960	COG1435	thymidine kinase activity
S100141_RS16965	COG0254	rRNA binding
S100141_RS16970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100141_RS16975	COG1494	fructose-1,6-bisphosphatase
S100141_RS16980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100141_RS16985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100141_RS16990	COG0191	fructose-bisphosphate aldolase activity
S100141_RS16995	COG2204	response regulator
S100141_RS17000	COG4821	SIS domain
S100141_RS17010	COG0504	CTP synthase activity
S100141_RS17015	COG3343	RNA polymerase activity
S100141_RS17020	COG1960	acyl-CoA dehydrogenase activity
S100141_RS17025	COG1960	acyl-CoA dehydrogenase activity
S100141_RS17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100141_RS17035	COG0183	Belongs to the thiolase family
S100141_RS17040	COG0247	lactate metabolic process
S100141_RS17040	COG2181	nitrate reductase activity
S100141_RS17045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100141_RS17055	COG0018	arginyl-trna synthetase
S100141_RS17060	COG4506	Protein conserved in bacteria
S100141_RS17065	COG0010	Belongs to the arginase family
S100141_RS17070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S100141_RS17085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100141_RS17095	COG1994	Peptidase M50
S100141_RS17100	COG1942	4-Oxalocrotonate Tautomerase
S100141_RS17110	COG3465	dGTPase activity
S100141_RS17115	COG1078	dGTPase activity
S100141_RS17120	COG4844	belongs to the
S100141_RS17145	COG2814	Major facilitator Superfamily
S100141_RS17170	COG1414	Transcriptional regulator
S100141_RS17180	COG0280	phosphate acetyltransferase
S100141_RS17185	COG3253	May function as heme-dependent peroxidase
S100141_RS17200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100141_RS17220	COG1131	(ABC) transporter
S100141_RS17235	COG2363	Small membrane protein
S100141_RS17240	COG2233	PERMEase
S100141_RS17250	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS17255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100141_RS17260	COG1216	Glycosyl transferase, family 2
S100141_RS17265	COG0351	phosphomethylpyrimidine kinase
S100141_RS17275	COG1621	beta-fructofuranosidase activity
S100141_RS17280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS17280	COG1263	PTS System
S100141_RS17285	COG3711	transcriptional antiterminator
S100141_RS17295	COG1404	Belongs to the peptidase S8 family
S100141_RS17305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100141_RS17310	COG0778	Nitroreductase
S100141_RS17315	COG1473	amidohydrolase
S100141_RS17320	COG0772	Belongs to the SEDS family
S100141_RS17325	COG0772	Belongs to the SEDS family
S100141_RS17330	COG3314	Sporulation integral membrane protein YlbJ
S100141_RS17350	COG0456	acetyltransferase
S100141_RS17385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100141_RS17395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100141_RS17400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100141_RS17405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100141_RS17425	COG3162	membrane
S100141_RS17430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS17435	COG1070	Carbohydrate kinase
S100141_RS17440	COG2115	Belongs to the xylose isomerase family
S100141_RS17450	COG0352	thiamine-phosphate diphosphorylase activity
S100141_RS17455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100141_RS17460	COG0583	DNA-binding transcription factor activity
S100141_RS17475	COG1380	Effector of murein hydrolase LrgA
S100141_RS17480	COG1346	cytolysis
S100141_RS17490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS17495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100141_RS17500	COG0346	lactoylglutathione lyase activity
S100141_RS17505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100141_RS17510	COG1442	glycosyl transferase family 8
S100141_RS17525	COG4585	Histidine kinase
S100141_RS17530	COG2197	response regulator
S100141_RS17535	COG2409	Drug exporters of the RND superfamily
S100141_RS17540	COG5522	Integral membrane protein (intg_mem_TP0381)
S100141_RS17545	COG2271	Major facilitator Superfamily
S100141_RS17550	COG4948	Mandelate Racemase Muconate Lactonizing
S100141_RS17555	COG0800	Aldolase
S100141_RS17560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100141_RS17570	COG2234	aminopeptidase activity
S100141_RS17575	COG0477	Major facilitator Superfamily
S100141_RS17585	COG2357	RelA SpoT domain protein
S100141_RS17600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS17605	COG1696	Membrane protein involved in D-alanine export
S100141_RS17610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100141_RS17615	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100141_RS17620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100141_RS17625	COG2814	Major facilitator Superfamily
S100141_RS17630	COG1486	melibiose metabolic process
S100141_RS17635	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100141_RS17640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS17645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS17650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS17650	COG3711	transcriptional antiterminator
S100141_RS17655	COG2094	Belongs to the DNA glycosylase MPG family
S100141_RS17665	COG0372	Belongs to the citrate synthase family
S100141_RS17670	COG2079	MmgE PrpD family protein
S100141_RS17675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S100141_RS17690	COG1132	(ABC) transporter
S100141_RS17695	COG2755	lipolytic protein G-D-S-L family
S100141_RS17710	COG2814	Major facilitator Superfamily
S100141_RS17715	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100141_RS17720	COG1131	(ABC) transporter
S100141_RS17740	COG1595	DNA-templated transcription, initiation
S100141_RS17745	COG2814	Major facilitator Superfamily
S100141_RS17750	COG0753	catalase activity
S100141_RS17755	COG0753	catalase activity
S100141_RS17760	COG0735	belongs to the Fur family
S100141_RS17765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S100141_RS17770	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100141_RS17775	COG1131	(ABC) transporter
S100141_RS17790	COG1131	(ABC) transporter
S100141_RS17845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100141_RS17850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100141_RS17855	COG4988	ABC transporter
S100141_RS17860	COG1294	oxidase, subunit
S100141_RS17865	COG1271	oxidase subunit
S100141_RS17875	COG2116	formate transmembrane transporter activity
S100141_RS17885	COG0281	malic enzyme
S100141_RS17890	COG1757	Na H antiporter
S100141_RS17895	COG1027	Aspartate ammonia-lyase
S100141_RS17900	COG0252	asparaginase activity
S100141_RS17905	COG1396	sequence-specific DNA binding
S100141_RS17910	COG2706	6-phosphogluconolactonase activity
S100141_RS17915	COG0745	RESPONSE REGULATOR receiver
S100141_RS17920	COG2205	protein histidine kinase activity
S100141_RS17930	COG1136	(ABC) transporter
S100141_RS17935	COG0577	efflux transmembrane transporter activity
S100141_RS17940	COG5294	Protein conserved in bacteria
S100141_RS17950	COG0726	polysaccharide deacetylase
S100141_RS17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100141_RS17960	COG1215	transferase activity, transferring glycosyl groups
S100141_RS17970	COG3493	citrate carrier protein
S100141_RS17975	COG0584	glycerophosphoryl diester phosphodiesterase
S100141_RS17990	COG1368	sulfuric ester hydrolase activity
S100141_RS18000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS18015	COG2235	arginine
S100141_RS18020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100141_RS18030	COG0549	Belongs to the carbamate kinase family
S100141_RS18040	COG2723	6-phospho-beta-galactosidase activity
S100141_RS18045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS18055	COG1595	DNA-templated transcription, initiation
S100141_RS18080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100141_RS18085	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100141_RS18095	COG1621	beta-fructofuranosidase activity
S100141_RS18100	COG2223	nitrite transmembrane transporter activity
S100141_RS18110	COG1609	Transcriptional regulator
S100141_RS18125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100141_RS18130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100141_RS18135	COG0463	Glycosyl transferase, family 2
S100141_RS18140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100141_RS18165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100141_RS18180	COG2723	6-phospho-beta-galactosidase activity
S100141_RS18185	COG2190	(PTS) system
S100141_RS18185	COG1263	PTS System
S100141_RS18185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS18190	COG3711	transcriptional antiterminator
S100141_RS18195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100141_RS18200	COG1122	ATPase activity
S100141_RS18205	COG4721	ABC-type cobalt transport system, permease component
S100141_RS18210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100141_RS18215	COG2224	Isocitrate lyase
S100141_RS18220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S100141_RS18230	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100141_RS18235	COG0577	efflux transmembrane transporter activity
S100141_RS18240	COG1136	(ABC) transporter
S100141_RS18245	COG2205	protein histidine kinase activity
S100141_RS18250	COG0745	RESPONSE REGULATOR receiver
S100141_RS18255	COG2723	6-phospho-beta-galactosidase activity
S100141_RS18260	COG2190	(PTS) system
S100141_RS18260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS18260	COG1263	PTS System
S100141_RS18270	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100141_RS18285	COG3507	Belongs to the glycosyl hydrolase 43 family
S100141_RS18315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100141_RS18320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100141_RS18325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100141_RS18330	COG2390	Transcriptional regulator
S100141_RS18345	COG3706	GGDEF domain
S100141_RS18355	COG1215	transferase activity, transferring glycosyl groups
S100141_RS18365	COG3977	Valine--pyruvate aminotransferase
S100141_RS18380	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100141_RS18390	COG0191	fructose-bisphosphate aldolase activity
S100141_RS18395	COG1082	Xylose isomerase domain protein TIM barrel
S100141_RS18400	COG1082	Xylose isomerase domain protein TIM barrel
S100141_RS18405	COG0673	inositol 2-dehydrogenase activity
S100141_RS18410	COG2814	Major facilitator Superfamily
S100141_RS18415	COG1082	Xylose isomerase domain protein TIM barrel
S100141_RS18420	COG3962	Belongs to the TPP enzyme family
S100141_RS18425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100141_RS18430	COG3718	enzyme involved in inositol metabolism
S100141_RS18435	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS18440	COG1349	DNA-binding transcription factor activity
S100141_RS18445	COG0667	Aldo Keto reductase
S100141_RS18450	COG0584	glycerophosphoryl diester phosphodiesterase
S100141_RS18455	COG2271	Major facilitator Superfamily
S100141_RS18460	COG0326	Molecular chaperone. Has ATPase activity
S100141_RS18465	COG0488	(ABC) transporter
S100141_RS18470	COG0561	phosphatase activity
S100141_RS18520	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S100141_RS18525	COG0577	efflux transmembrane transporter activity
S100141_RS18530	COG1136	(ABC) transporter
S100141_RS18535	COG2205	protein histidine kinase activity
S100141_RS18540	COG0745	RESPONSE REGULATOR receiver
S100141_RS18550	COG0840	transmembrane signaling receptor activity
S100141_RS18550	COG5278	phosphoserine phosphatase activity
S100141_RS18555	COG1115	amino acid carrier protein
S100141_RS18560	COG0686	Belongs to the AlaDH PNT family
S100141_RS18565	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S100141_RS18570	COG1874	Beta-galactosidase
S100141_RS18575	COG3833	ABC-type maltose transport systems, permease component
S100141_RS18580	COG1175	transmembrane transport
S100141_RS18585	COG2182	Extracellular solute-binding protein
S100141_RS18590	COG1609	Transcriptional regulator
S100141_RS18600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100141_RS18605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100141_RS18610	COG1940	carbohydrate kinase activity
S100141_RS18635	COG1454	alcohol dehydrogenase
S100141_RS18635	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS18650	COG3634	alkyl hydroperoxide reductase activity
S100141_RS18675	COG1131	(ABC) transporter
S100141_RS18680	COG0842	Transport permease protein
S100141_RS18690	COG2197	response regulator
S100141_RS18715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100141_RS18730	COG0456	acetyltransferase
S100141_RS18745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100141_RS18750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100141_RS18755	COG4853	Protein conserved in bacteria
S100141_RS18760	COG4863	YycH protein
S100141_RS18765	COG5002	protein histidine kinase activity
S100141_RS18770	COG0745	RESPONSE REGULATOR receiver
S100141_RS18795	COG1051	belongs to the nudix hydrolase family
S100141_RS18800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S100141_RS18810	COG0305	Participates in initiation and elongation during chromosome replication
S100141_RS18825	COG3093	addiction module antidote protein HigA
S100141_RS18830	COG2807	transmembrane transport
S100141_RS18835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S100141_RS18840	COG0363	glucosamine-6-phosphate deaminase activity
S100141_RS18845	COG2188	Transcriptional regulator
S100141_RS18850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100141_RS18855	COG1263	PTS System
S100141_RS18855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS18860	COG0359	binds to the 23S rRNA
S100141_RS18865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S100141_RS18870	COG4241	membrane
S100141_RS18880	COG5577	PFAM Coat F domain
S100141_RS18885	COG0589	response to stress
S100141_RS18890	COG0659	secondary active sulfate transmembrane transporter activity
S100141_RS18895	COG2271	Major facilitator Superfamily
S100141_RS18900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100141_RS18905	COG0629	single-stranded DNA binding
S100141_RS18910	COG0360	Binds together with S18 to 16S ribosomal RNA
S100141_RS18915	COG0012	GTP binding
S100141_RS18925	COG4481	Protein conserved in bacteria
S100141_RS18930	COG3949	Membrane
S100141_RS18940	COG1475	DNA binding
S100141_RS18945	COG1192	Involved in chromosome partitioning
S100141_RS18950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100141_RS18960	COG1475	DNA binding
S100141_RS18965	COG0357	Ribosomal RNA small subunit methyltransferase G
S100141_RS18970	COG0445	tRNA wobble uridine modification
S100141_RS18975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100141_RS18980	COG1847	R3H domain protein
S100141_RS18985	COG0706	membrane insertase activity
S100141_RS18990	COG0594	ribonuclease P activity
S100141_RS19000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100141_RS19005	COG0592	DNA-directed DNA polymerase activity
S100141_RS19010	COG2501	S4 domain
S100141_RS19015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100141_RS19025	COG0187	DNA topoisomerase II activity
S100141_RS19030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100141_RS19065	COG0516	GMP reductase activity
S100141_RS19065	COG0517	IMP dehydrogenase activity
S100141_RS19070	COG1686	Belongs to the peptidase S11 family
S100141_RS19075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S100141_RS19080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S100141_RS19085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100141_RS19090	COG1929	Belongs to the glycerate kinase type-1 family
S100141_RS19100	COG3835	regulator
S100141_RS19115	COG1428	Deoxynucleoside kinase
S100141_RS19120	COG1428	Deoxynucleoside kinase
S100141_RS19125	COG3858	chitin binding
S100141_RS19125	COG1388	LysM domain
S100141_RS19130	COG1335	isochorismatase
S100141_RS19135	COG0590	tRNA wobble adenosine to inosine editing
S100141_RS19145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100141_RS19150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100141_RS19155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100141_RS19200	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S100141_RS19205	COG3853	Toxic anion resistance protein (TelA)
S100141_RS19210	COG1982	Orn Lys Arg decarboxylase major
S100141_RS19215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100141_RS19220	COG3870	Protein conserved in bacteria
S100141_RS19225	COG1728	Protein conserved in bacteria
S100141_RS19230	COG0470	DNA polymerase III
S100141_RS19235	COG1774	PSP1 C-terminal conserved region
S100141_RS19240	COG4467	Involved in initiation control of chromosome replication
S100141_RS19245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100141_RS19250	COG2827	Endonuclease containing a URI domain
S100141_RS19255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S100141_RS19260	COG2002	toxin-antitoxin pair type II binding
S100141_RS19265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100141_RS19265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100141_RS19270	COG0084	hydrolase, TatD family'
S100141_RS19275	COG3584	3D domain protein
S100141_RS19275	COG3583	domain protein
S100141_RS19280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100141_RS19285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100141_RS19295	COG4466	Protein conserved in bacteria
S100141_RS19305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100141_RS19310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100141_RS19315	COG0251	oxidation-reduction process
S100141_RS19320	COG2088	sporulation resulting in formation of a cellular spore
S100141_RS19325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100141_RS19330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100141_RS19335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S100141_RS19340	COG0193	aminoacyl-tRNA hydrolase activity
S100141_RS19350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100141_RS19355	COG2002	toxin-antitoxin pair type II binding
S100141_RS19360	COG2244	polysaccharide biosynthetic process
S100141_RS19365	COG3956	TIGRFAM MazG family protein
S100141_RS19370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100141_RS19385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S100141_RS19390	COG1098	S1 RNA binding domain
S100141_RS19405	COG2208	phosphoserine phosphatase activity
S100141_RS19410	COG2304	oxidoreductase activity
S100141_RS19420	COG0037	tRNA processing
S100141_RS19425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S100141_RS19435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S100141_RS19440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100141_RS19445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100141_RS19450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100141_RS19460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100141_RS19465	COG0512	Glutamine amidotransferase of anthranilate synthase
S100141_RS19470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100141_RS19475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100141_RS19480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S100141_RS19485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100141_RS19490	COG1396	sequence-specific DNA binding
S100141_RS19495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100141_RS19500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100141_RS19580	COG4463	regulation of RNA biosynthetic process
S100141_RS19585	COG3880	PFAM UvrB UvrC protein
S100141_RS19590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S100141_RS19595	COG0542	response to heat
S100141_RS19600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100141_RS19605	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S100141_RS19610	COG4956	integral membrane protein (PIN domain superfamily)
S100141_RS19615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100141_RS19620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S100141_RS19625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100141_RS19630	COG1045	serine acetyltransferase
S100141_RS19635	COG0215	cysteine-tRNA ligase activity
S100141_RS19640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100141_RS19645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100141_RS19650	COG3688	RNA-binding protein containing a PIN domain
S100141_RS19660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100141_RS19670	COG0250	Participates in transcription elongation, termination and antitermination
S100141_RS19675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S100141_RS19680	COG0081	regulation of translation
S100141_RS19685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100141_RS19690	COG0222	ribosome binding
S100141_RS19695	COG2813	Specifically methylates the guanine in position
S100141_RS19700	COG0085	RNA polymerase activity
S100141_RS19705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100141_RS19710	COG1358	cellular component organization or biogenesis
S100141_RS19715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100141_RS19720	COG0049	tRNA binding
S100141_RS19725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100141_RS19730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100141_RS19740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100141_RS19745	COG0088	Forms part of the polypeptide exit tunnel
S100141_RS19750	COG0089	rRNA binding
S100141_RS19755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100141_RS19760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100141_RS19765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100141_RS19770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100141_RS19775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100141_RS19780	COG0255	Belongs to the universal ribosomal protein uL29 family
S100141_RS19785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100141_RS19790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100141_RS19795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S100141_RS19800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100141_RS19805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100141_RS19810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100141_RS19815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100141_RS19820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100141_RS19825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S100141_RS19830	COG1841	ribosomal large subunit assembly
S100141_RS19835	COG0200	Binds to the 23S rRNA
S100141_RS19840	COG0201	protein transport
S100141_RS19845	COG0563	adenylate kinase activity
S100141_RS19850	COG0024	Methionine aminopeptidase
S100141_RS19855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S100141_RS19860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100141_RS19865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100141_RS19870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100141_RS19875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100141_RS19880	COG0202	RNA polymerase activity
S100141_RS19885	COG0203	ribosomal protein L17
S100141_RS19890	COG1122	ATPase activity
S100141_RS19895	COG1122	ATPase activity
S100141_RS19900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100141_RS19905	COG0101	tRNA pseudouridine synthase activity
S100141_RS19910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100141_RS19915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100141_RS19920	COG2318	DinB family
S100141_RS19930	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS19935	COG0489	protein tyrosine kinase activity
S100141_RS19945	COG2194	sulfuric ester hydrolase activity
S100141_RS19950	COG0726	polysaccharide deacetylase
S100141_RS19980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100141_RS19990	COG0385	Bile acid
S100141_RS20005	COG3876	Protein conserved in bacteria
S100141_RS20010	COG1472	Belongs to the glycosyl hydrolase 3 family
S100141_RS20015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100141_RS20020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS20020	COG1263	PTS System
S100141_RS20025	COG1737	Transcriptional regulator
S100141_RS20030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100141_RS20035	COG1683	Conserved Protein
S100141_RS20070	COG1595	DNA-templated transcription, initiation
S100141_RS20075	COG5662	AntiSigma factor
S100141_RS20080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100141_RS20085	COG4856	YbbR-like protein
S100141_RS20090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100141_RS20095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100141_RS20115	COG1725	Transcriptional regulator
S100141_RS20120	COG0640	Transcriptional regulator
S100141_RS20125	COG2814	Major facilitator Superfamily
S100141_RS20135	COG1132	(ABC) transporter
S100141_RS20140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100141_RS20165	COG1011	Hydrolase
S100141_RS20170	COG1113	amino acid transport
S100141_RS20175	COG2851	Citrate transporter
S100141_RS20180	COG3181	Tripartite tricarboxylate transporter family receptor
S100141_RS20185	COG4565	transcriptional regulatory protein
S100141_RS20190	COG3290	protein histidine kinase activity
S100141_RS20205	COG2211	Major facilitator Superfamily
S100141_RS20225	COG1331	Highly conserved protein containing a thioredoxin domain
S100141_RS20230	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S100141_RS20235	COG1331	Highly conserved protein containing a thioredoxin domain
S100141_RS20245	COG0477	Major facilitator Superfamily
S100141_RS20265	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100141_RS20270	COG4682	membrane
S100141_RS20295	COG0697	spore germination
S100141_RS20300	COG1917	Cupin 2, conserved barrel domain protein
S100141_RS20300	COG2207	Transcriptional regulator
S100141_RS20320	COG0371	Dehydrogenase
S100141_RS20325	COG0840	transmembrane signaling receptor activity
S100141_RS20330	COG4213	ABC transporter substrate-binding protein
S100141_RS20345	COG4257	antibiotic catabolic process
S100141_RS20355	COG0833	amino acid
S100141_RS20360	COG2040	homocysteine
S100141_RS20370	COG1263	PTS System
S100141_RS20370	COG2190	(PTS) system
S100141_RS20370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS20375	COG0789	Transcriptional regulator
S100141_RS20380	COG2323	membrane
S100141_RS20385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100141_RS20385	COG4451	ribulose bisphosphate carboxylase, small
S100141_RS20395	COG2205	protein histidine kinase activity
S100141_RS20400	COG1115	amino acid carrier protein
S100141_RS20405	COG2066	Belongs to the glutaminase family
S100141_RS20410	COG4191	Histidine kinase
S100141_RS20415	COG0784	Response regulator, receiver
S100141_RS20440	COG3540	Alkaline phosphatase
S100141_RS20445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100141_RS20450	COG0805	protein transport
S100141_RS20455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100141_RS20460	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS20465	COG2271	Major facilitator Superfamily
S100141_RS20470	COG4948	Mandelate Racemase Muconate Lactonizing
S100141_RS20475	COG2186	Transcriptional regulator
S100141_RS20480	COG2721	sulfolactate sulfo-lyase activity
S100141_RS20485	COG0745	RESPONSE REGULATOR receiver
S100141_RS20490	COG2205	protein histidine kinase activity
S100141_RS20495	COG1131	(ABC) transporter
S100141_RS20520	COG3173	Aminoglycoside phosphotransferase
S100141_RS20525	COG1846	Transcriptional regulator
S100141_RS20530	COG0318	PFAM AMP-dependent synthetase and ligase
S100141_RS20550	COG0789	Transcriptional regulator
S100141_RS20575	COG0697	spore germination
S100141_RS20580	COG1714	RDD family
S100141_RS20585	COG3012	SEC-C Motif Domain Protein
S100141_RS20585	COG1405	negative regulation of cell septum assembly
S100141_RS20590	COG1131	(ABC) transporter
S100141_RS20615	COG0583	DNA-binding transcription factor activity
S100141_RS20620	COG1942	4-Oxalocrotonate Tautomerase
S100141_RS20625	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS20640	COG1288	antiporter activity
S100141_RS20650	COG0456	acetyltransferase
S100141_RS20660	COG1164	Oligoendopeptidase f
S100141_RS20665	COG2261	transglycosylase associated protein
S100141_RS20675	COG0247	lactate metabolic process
S100141_RS20680	COG0277	FAD linked oxidase domain protein
S100141_RS20685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS20690	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100141_RS20695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100141_RS20700	COG1486	melibiose metabolic process
S100141_RS20705	COG2188	Transcriptional regulator
S100141_RS20710	COG3394	polysaccharide catabolic process
S100141_RS20725	COG3591	Belongs to the peptidase S1B family
S100141_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS20740	COG1595	DNA-templated transcription, initiation
S100141_RS20750	COG3773	Cell wall hydrolase
S100141_RS20755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100141_RS20760	COG0791	NLP P60 protein
S100141_RS20760	COG3883	PFAM NLP P60 protein
S100141_RS20770	COG1131	(ABC) transporter
S100141_RS20775	COG1309	transcriptional regulator
S100141_RS20795	COG2310	stress, protein
S100141_RS20800	COG2310	stress, protein
S100141_RS20805	COG2310	stress, protein
S100141_RS20810	COG0861	Integral membrane protein TerC family
S100141_RS20830	COG3853	Toxic anion resistance protein (TelA)
S100141_RS20835	COG0785	Cytochrome C biogenesis protein
S100141_RS20845	COG0789	Transcriptional regulator
S100141_RS20850	COG2223	nitrite transmembrane transporter activity
S100141_RS20855	COG0039	L-malate dehydrogenase activity
S100141_RS20860	COG1620	l-lactate permease
S100141_RS20865	COG1280	lysine exporter protein (LysE YggA)
S100141_RS20870	COG1113	amino acid transport
S100141_RS20875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100141_RS20880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100141_RS20885	COG3541	Predicted nucleotidyltransferase
S100141_RS20890	COG0506	proline dehydrogenase activity
S100141_RS20895	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS20900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS20905	COG2508	Transcriptional regulator
S100141_RS20910	COG3689	TIGRFAM TIGR03943 family protein
S100141_RS20915	COG0701	Predicted permease
S100141_RS20920	COG3458	cephalosporin-C deacetylase activity
S100141_RS20940	COG0765	amino acid transport
S100141_RS20945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100141_RS20950	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100141_RS20960	COG2723	6-phospho-beta-galactosidase activity
S100141_RS20970	COG3209	COG3209 Rhs family protein
S100141_RS20975	COG3266	domain, Protein
S100141_RS20975	COG0515	serine threonine protein kinase
S100141_RS20985	COG5444	nuclease activity
S100141_RS21010	COG1176	ABC-type spermidine putrescine transport system, permease component I
S100141_RS21020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS21025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS21030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100141_RS21035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S100141_RS21040	COG0697	spore germination
S100141_RS21045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100141_RS21055	COG2819	hydrolase of the alpha beta superfamily
S100141_RS21065	COG2364	Membrane
S100141_RS21075	COG1131	(ABC) transporter
S100141_RS21100	COG1126	abc transporter atp-binding protein
S100141_RS21105	COG0765	amino acid transport
S100141_RS21110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100141_RS21115	COG3829	transcription factor binding
S100141_RS21120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100141_RS21125	COG0833	amino acid
S100141_RS21130	COG0010	Belongs to the arginase family
S100141_RS21135	COG0583	DNA-binding transcription factor activity
S100141_RS21140	COG0163	prenyltransferase activity
S100141_RS21145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S100141_RS21195	COG5444	nuclease activity
S100141_RS21215	COG2972	Histidine kinase
S100141_RS21220	COG2207	Transcriptional regulator
S100141_RS21220	COG4753	response regulator
S100141_RS21225	COG4213	ABC transporter substrate-binding protein
S100141_RS21235	COG4214	carbohydrate transport
S100141_RS21240	COG2271	Major facilitator Superfamily
S100141_RS21245	COG1846	Transcriptional regulator
S100141_RS21245	COG0456	acetyltransferase
S100141_RS21250	COG1874	Beta-galactosidase
S100141_RS21255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S100141_RS21260	COG3104	oligopeptide transport
S100141_RS21265	COG5434	Belongs to the glycosyl hydrolase 28 family
S100141_RS21275	COG0697	spore germination
S100141_RS21285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100141_RS21290	COG0789	Transcriptional regulator
S100141_RS21295	COG1136	(ABC) transporter
S100141_RS21300	COG0577	efflux transmembrane transporter activity
S100141_RS21305	COG0745	RESPONSE REGULATOR receiver
S100141_RS21310	COG5002	protein histidine kinase activity
S100141_RS21310	COG3850	Histidine kinase
S100141_RS21320	COG0527	aspartate kinase activity
S100141_RS21325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100141_RS21330	COG4605	iron ion homeostasis
S100141_RS21335	COG4604	ABC transporter, ATP-binding protein
S100141_RS21340	COG4607	ABC-type enterochelin transport system periplasmic component
S100141_RS21345	COG2814	Major facilitator Superfamily
S100141_RS21350	COG1309	transcriptional regulator
S100141_RS21360	COG0778	Nitroreductase
S100141_RS21365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100141_RS21370	COG0640	Transcriptional regulator
S100141_RS21375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100141_RS21380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S100141_RS21385	COG0531	amino acid
S100141_RS21390	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS21395	COG0697	spore germination
S100141_RS21405	COG4549	nuclear export factor GLE1
S100141_RS21410	COG2372	response to copper ion
S100141_RS21410	COG1276	copper resistance
S100141_RS21415	COG1349	DNA-binding transcription factor activity
S100141_RS21420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100141_RS21425	COG0243	molybdopterin cofactor binding
S100141_RS21430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100141_RS21435	COG2146	nitrite reductase [NAD(P)H] activity
S100141_RS21440	COG1587	Uroporphyrinogen-III synthase
S100141_RS21440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100141_RS21445	COG1802	Transcriptional regulator
S100141_RS21450	COG0471	metal ion transport
S100141_RS21455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100141_RS21460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100141_RS21475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS21490	COG3959	Transketolase, thiamine diphosphate binding domain
S100141_RS21495	COG3958	Transketolase
S100141_RS21500	COG0561	phosphatase activity
S100141_RS21505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S100141_RS21510	COG1914	H( )-stimulated, divalent metal cation uptake system
S100141_RS21515	COG4336	lyase activity
S100141_RS21520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S100141_RS21525	COG1984	allophanate hydrolase subunit 2
S100141_RS21530	COG1414	Transcriptional regulator
S100141_RS21535	COG2755	lipolytic protein G-D-S-L family
S100141_RS21540	COG2213	PTS system mannitol-specific
S100141_RS21545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100141_RS21550	COG0246	Mannitol dehydrogenase
S100141_RS21555	COG3711	transcriptional antiterminator
S100141_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS21565	COG1917	Cupin 2, conserved barrel domain protein
S100141_RS21575	COG3871	stress protein (general stress protein 26)
S100141_RS21590	COG2814	Major facilitator Superfamily
S100141_RS21600	COG1522	sequence-specific DNA binding
S100141_RS21605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100141_RS21605	COG0551	DNA topoisomerase type I activity
S100141_RS21615	COG0028	Belongs to the TPP enzyme family
S100141_RS21620	COG3397	chitin binding
S100141_RS21635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS21640	COG1914	H( )-stimulated, divalent metal cation uptake system
S100141_RS21645	COG2261	transglycosylase associated protein
S100141_RS21650	COG1027	Aspartate ammonia-lyase
S100141_RS21655	COG1819	glycosyl
S100141_RS21660	COG4876	unkown
S100141_RS21665	COG2217	Heavy metal translocating P-type atpase
S100141_RS21675	COG0662	Cupin 2, conserved barrel domain protein
S100141_RS21680	COG3729	General stress protein
S100141_RS21685	COG0628	permease
S100141_RS21690	COG1301	dicarboxylic acid transport
S100141_RS21695	COG1131	(ABC) transporter
S100141_RS21700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100141_RS21710	COG1960	acyl-CoA dehydrogenase activity
S100141_RS21725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100141_RS21730	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100141_RS21735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100141_RS21745	COG0513	Belongs to the DEAD box helicase family
S100141_RS21750	COG3402	PFAM membrane-flanked domain
S100141_RS21755	COG3428	Bacterial PH domain
S100141_RS21760	COG0705	Rhomboid family
S100141_RS21765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S100141_RS21770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100141_RS21775	COG0864	Transcriptional regulator
S100141_RS21780	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100141_RS21785	COG1366	Belongs to the anti-sigma-factor antagonist family
S100141_RS21790	COG1366	Belongs to the anti-sigma-factor antagonist family
S100141_RS21795	COG2172	sigma factor antagonist activity
S100141_RS21800	COG2208	phosphoserine phosphatase activity
S100141_RS21810	COG2172	sigma factor antagonist activity
S100141_RS21815	COG1191	sigma factor activity
S100141_RS21820	COG2208	phosphoserine phosphatase activity
S100141_RS21825	COG2183	response to ionizing radiation
S100141_RS21830	COG1309	transcriptional regulator
S100141_RS21835	COG2409	Drug exporters of the RND superfamily
S100141_RS21835	COG1033	growth of symbiont in host cell
S100141_RS21845	COG3091	SprT-like family
S100141_RS21895	COG1476	TRANSCRIPTIONal
S100141_RS21900	COG3239	Fatty acid desaturase
S100141_RS21905	COG1278	Cold shock
S100141_RS21910	COG1063	alcohol dehydrogenase
S100141_RS21920	COG2364	Membrane
S100141_RS21925	COG1846	Transcriptional regulator
S100141_RS21930	COG0456	acetyltransferase
S100141_RS21935	COG2808	Putative FMN-binding domain
S100141_RS21945	COG1733	regulation of RNA biosynthetic process
S100141_RS21950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100141_RS21960	COG0583	DNA-binding transcription factor activity
S100141_RS21975	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
S100141_RS21980	COG1113	amino acid transport
S100141_RS21995	COG1595	DNA-templated transcription, initiation
S100141_RS22005	COG2755	lipolytic protein G-D-S-L family
S100141_RS22005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100141_RS22010	COG2814	Major facilitator Superfamily
S100141_RS22015	COG0745	RESPONSE REGULATOR receiver
S100141_RS22015	COG2972	Histidine kinase
S100141_RS22020	COG3279	Response regulator of the LytR AlgR family
S100141_RS22030	COG3764	Sortase (surface protein transpeptidase)
S100141_RS22075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S100141_RS22080	COG0802	atpase or kinase
S100141_RS22085	COG1214	PFAM Peptidase M22, glycoprotease
S100141_RS22090	COG0456	acetyltransferase
S100141_RS22095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100141_RS22100	COG0488	(ABC) transporter
S100141_RS22105	COG0315	cyclic pyranopterin monophosphate synthase activity
S100141_RS22110	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100141_RS22115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100141_RS22120	COG0805	protein transport
S100141_RS22130	COG1266	CAAX protease self-immunity
S100141_RS22135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100141_RS22140	COG0459	protein refolding
S100141_RS22175	COG2720	vancomycin resistance protein
S100141_RS22190	COG2135	peptidase activity
S100141_RS22205	COG3848	Pyruvate phosphate dikinase
S100141_RS22205	COG0574	Belongs to the PEP-utilizing enzyme family
S100141_RS22215	COG3189	MarR family transcriptional regulator
S100141_RS22220	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100141_RS22225	COG2272	Belongs to the type-B carboxylesterase lipase family
S100141_RS22230	COG2814	Major facilitator Superfamily
S100141_RS22235	COG1842	Phage shock protein A
S100141_RS22240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100141_RS22245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S100141_RS22250	COG4260	virion core protein, lumpy skin disease virus
S100141_RS22260	COG1378	Sugar-specific transcriptional regulator TrmB
S100141_RS22265	COG1280	lysine exporter protein (LysE YggA)
S100141_RS22270	COG3339	Conserved Protein
S100141_RS22275	COG0772	Belongs to the SEDS family
S100141_RS22280	COG0772	Belongs to the SEDS family
S100141_RS22305	COG0726	polysaccharide deacetylase
S100141_RS22315	COG1609	Transcriptional regulator
S100141_RS22320	COG0366	Alpha amylase catalytic
S100141_RS22325	COG2182	Extracellular solute-binding protein
S100141_RS22330	COG1175	transmembrane transport
S100141_RS22335	COG3833	ABC-type maltose transport systems, permease component
S100141_RS22340	COG5521	maltodextrose utilization protein MalA
S100141_RS22345	COG1554	hydrolase, family 65, central catalytic
S100141_RS22350	COG0366	Alpha amylase catalytic
S100141_RS22360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100141_RS22365	COG1846	Transcriptional regulator
S100141_RS22380	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S100141_RS22385	COG0823	Involved in the tonB-independent uptake of proteins
S100141_RS22415	COG0702	epimerase
S100141_RS22425	COG2132	Multicopper oxidase
S100141_RS22440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100141_RS22445	COG0714	Associated with various cellular activities
S100141_RS22450	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S100141_RS22455	COG1305	Transglutaminase-like
S100141_RS22460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100141_RS22460	COG0519	Catalyzes the synthesis of GMP from XMP
S100141_RS22470	COG2252	PERMEase
S100141_RS22485	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100141_RS22495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100141_RS22500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100141_RS22505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100141_RS22510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100141_RS22515	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100141_RS22520	COG0047	phosphoribosylformylglycinamidine synthase activity
S100141_RS22525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100141_RS22530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S100141_RS22535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100141_RS22540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100141_RS22545	COG0138	bifunctional purine biosynthesis protein purh
S100141_RS22550	COG0151	Belongs to the GarS family
S100141_RS22565	COG2124	cytochrome p450
S100141_RS22585	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100141_RS22590	COG1470	cell adhesion involved in biofilm formation
S100141_RS22595	COG4496	protein, YerC YecD
S100141_RS22600	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S100141_RS22605	COG0210	DNA helicase
S100141_RS22610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100141_RS22615	COG4851	CamS sex pheromone cAM373 precursor
S100141_RS22625	COG2188	Transcriptional regulator
S100141_RS22645	COG1735	metal-dependent hydrolase with the TIM-barrel fold
S100141_RS22650	COG0626	cystathionine gamma-synthase activity
S100141_RS22655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100141_RS22660	COG3457	Alanine racemase
S100141_RS22665	COG0363	glucosamine-6-phosphate deaminase activity
S100141_RS22670	COG1285	pathogenesis
S100141_RS22675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100141_RS22680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100141_RS22685	COG0154	amidase activity
S100141_RS22690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100141_RS22705	COG4124	Belongs to the glycosyl hydrolase 26 family
S100141_RS22710	COG1309	transcriptional regulator
S100141_RS22715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S100141_RS22725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100141_RS22735	COG1597	lipid kinase activity
S100141_RS22740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100141_RS22745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100141_RS22770	COG3645	SOS response
S100141_RS22780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S100141_RS22805	COG2190	(PTS) system
S100141_RS22805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS22805	COG1263	PTS System
S100141_RS22810	COG2723	6-phospho-beta-galactosidase activity
S100141_RS22815	COG3711	transcriptional antiterminator
S100141_RS22820	COG0457	Tetratricopeptide repeat
S100141_RS22840	COG0217	transcriptional regulatory protein
S100141_RS22855	COG1012	belongs to the aldehyde dehydrogenase family
S100141_RS22860	COG0840	transmembrane signaling receptor activity
S100141_RS22865	COG0471	metal ion transport
S100141_RS22875	COG1469	GTP cyclohydrolase I activity
S100141_RS22890	COG0523	cobalamin synthesis protein
S100141_RS22900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100141_RS22905	COG0156	8-amino-7-oxononanoate synthase activity
S100141_RS22910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S100141_RS22915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S100141_RS22920	COG2124	cytochrome p450
S100141_RS22930	COG0789	Transcriptional regulator
S100141_RS22935	COG2814	Major facilitator Superfamily
S100141_RS22940	COG0488	(ABC) transporter
S100141_RS22945	COG0513	Belongs to the DEAD box helicase family
S100141_RS22950	COG2130	NADP-dependent
S100141_RS22965	COG0471	metal ion transport
S100141_RS22980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100141_RS22990	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S100141_RS22995	COG5658	integral membrane protein
S100141_RS23000	COG0640	Transcriptional regulator
S100141_RS23005	COG1254	Belongs to the acylphosphatase family
S100141_RS23010	COG2258	MOSC domain
S100141_RS23025	COG0024	Methionine aminopeptidase
S100141_RS23030	COG1368	sulfuric ester hydrolase activity
S100141_RS23040	COG1115	amino acid carrier protein
S100141_RS23045	COG1263	PTS System
S100141_RS23045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS23050	COG0366	Alpha amylase catalytic
S100141_RS23055	COG2188	Transcriptional regulator
S100141_RS23085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100141_RS23090	COG1045	serine acetyltransferase
S100141_RS23095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100141_RS23105	COG1215	transferase activity, transferring glycosyl groups
S100141_RS23110	COG0457	Tetratricopeptide repeat
S100141_RS23110	COG0463	Glycosyl transferase, family 2
S100141_RS23120	COG0673	inositol 2-dehydrogenase activity
S100141_RS23130	COG0657	acetylesterase activity
S100141_RS23135	COG1733	regulation of RNA biosynthetic process
S100141_RS23140	COG0778	Nitroreductase
S100141_RS23150	COG0693	protein deglycase activity
S100141_RS23155	COG4840	Belongs to the UPF0435 family
S100141_RS23160	COG1115	amino acid carrier protein
S100141_RS23165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100141_RS23170	COG4980	gas vesicle protein
S100141_RS23180	COG0477	Major facilitator Superfamily
S100141_RS23190	COG0387	Pfam Sodium calcium exchanger
S100141_RS23200	COG0535	radical SAM domain protein
S100141_RS23210	COG0726	polysaccharide deacetylase
S100141_RS23225	COG0598	Magnesium transport protein CorA
S100141_RS23230	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100141_RS23235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100141_RS23240	COG4637	Psort location Cytoplasmic, score
S100141_RS23265	COG1819	glycosyl
S100141_RS23275	COG0477	Major facilitator Superfamily
S100141_RS23280	COG1263	PTS System
S100141_RS23280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS23285	COG3711	transcriptional antiterminator
S100141_RS23290	COG0288	reversible hydration of carbon dioxide
S100141_RS23295	COG3002	Belongs to the UPF0753 family
S100141_RS23300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100141_RS23305	COG5609	conserved protein (DUF2294)
S100141_RS23315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100141_RS23320	COG0022	dehydrogenase e1 component
S100141_RS23325	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100141_RS23330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100141_RS23335	COG3284	Transcriptional regulator
S100141_RS23340	COG1742	UPF0060 membrane protein
S100141_RS23345	COG1486	melibiose metabolic process
S100141_RS23350	COG1737	Transcriptional regulator
S100141_RS23355	COG1263	PTS System
S100141_RS23355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100141_RS23370	COG1733	regulation of RNA biosynthetic process
S100141_RS23375	COG2259	Doxx family
S100141_RS23380	COG2514	catechol 2,3-dioxygenase activity
S100141_RS23390	COG3507	Belongs to the glycosyl hydrolase 43 family
S100141_RS23395	COG1917	Cupin 2, conserved barrel domain protein
S100141_RS23395	COG2207	Transcriptional regulator
S100141_RS23400	COG1653	transport
S100141_RS23410	COG1051	belongs to the nudix hydrolase family
S100141_RS23420	COG0392	lysyltransferase activity
S100141_RS23420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S100141_RS23425	COG0384	phenazine biosynthesis protein PhzF
S100141_RS23430	COG0778	Nitroreductase
S100141_RS23450	COG1090	epimerase
S100141_RS23455	COG2137	regulation of response to DNA damage stimulus
S100141_RS23485	COG0463	Glycosyl transferase, family 2
S100141_RS23495	COG4485	Bacterial membrane protein, YfhO
S100141_RS23500	COG1988	membrane-bound metal-dependent
S100141_RS23505	COG1194	a g-specific adenine glycosylase
S100141_RS23515	COG1028	Short-chain dehydrogenase reductase Sdr
S100141_RS23530	COG3557	Belongs to the UPF0374 family
S100141_RS23535	COG1132	(ABC) transporter
S100141_RS23540	COG0444	Belongs to the ABC transporter superfamily
S100141_RS23545	COG4608	Belongs to the ABC transporter superfamily
S100141_RS23550	COG0747	negative chemotaxis
S100141_RS23555	COG0601	transmembrane transport
S100141_RS23560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100141_RS23565	COG4129	membrane
S100141_RS23570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100141_RS23575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S100141_RS23580	COG0735	belongs to the Fur family
S100141_RS23685	COG4974	Belongs to the 'phage' integrase family
S100141_RS23805	COG0358	DNA primase activity
S100141_RS23815	COG0210	DNA helicase
S100141_RS23865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100141_RS23970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100141_RS24000	COG3584	3D domain protein
S100141_RS24010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100141_RS24435	COG0741	lytic transglycosylase activity
S100141_RS24435	COG0791	NLP P60 protein
S100141_RS24615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS24625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100141_RS24630	COG4112	unkown
S100141_RS24650	COG2131	deaminase
S100141_RS24725	COG0194	GDP metabolic process
S100141_RS24770	COG0457	Tetratricopeptide repeat
S100141_RS24775	COG2814	Major facilitator Superfamily
S100141_RS24790	COG5444	nuclease activity
S100141_RS24810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100141_RS24845	COG0592	DNA-directed DNA polymerase activity
S100141_RS24870	COG2333	competence protein COMEC
S100141_RS24870	COG0658	competence protein
S100141_RS24880	COG2131	deaminase
S100141_RS24895	COG2226	methyltransferase
S100141_RS24900	COG0799	negative regulation of ribosome biogenesis
S100141_RS24910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100141_RS24915	COG1534	Rna-binding protein
S100141_RS24920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100141_RS24925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100141_RS24955	COG3383	formate dehydrogenase (NAD+) activity
S100141_RS24990	COG0300	oxidoreductase activity
S100141_RS25000	COG0596	Alpha beta hydrolase
S100141_RS25000	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100141_RS25005	COG1309	transcriptional regulator
S100141_RS25050	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100141_RS25135	COG0730	response to heat
S100141_RS25140	COG0425	Belongs to the sulfur carrier protein TusA family
S100141_RS25205	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100141_RS25210	COG1121	(ABC) transporter
S100141_RS25230	COG1942	4-Oxalocrotonate Tautomerase
S100141_RS25250	COG1733	regulation of RNA biosynthetic process
S100141_RS25270	COG0492	ferredoxin-NADP+ reductase activity