locus-tag	class	description
S101441_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101441_RS00010	COG0592	DNA-directed DNA polymerase activity
S101441_RS00015	COG2501	S4 domain
S101441_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101441_RS00030	COG0187	DNA topoisomerase II activity
S101441_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101441_RS00070	COG0516	GMP reductase activity
S101441_RS00070	COG0517	IMP dehydrogenase activity
S101441_RS00075	COG1686	Belongs to the peptidase S11 family
S101441_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S101441_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S101441_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S101441_RS00100	COG1428	Deoxynucleoside kinase
S101441_RS00105	COG1428	Deoxynucleoside kinase
S101441_RS00110	COG1388	LysM domain
S101441_RS00110	COG3858	chitin binding
S101441_RS00115	COG1335	isochorismatase
S101441_RS00120	COG0590	tRNA wobble adenosine to inosine editing
S101441_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S101441_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101441_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101441_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S101441_RS00190	COG3853	Toxic anion resistance protein (TelA)
S101441_RS00195	COG1982	Orn Lys Arg decarboxylase major
S101441_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101441_RS00205	COG3870	Protein conserved in bacteria
S101441_RS00210	COG1728	Protein conserved in bacteria
S101441_RS00215	COG0470	DNA polymerase III
S101441_RS00220	COG1774	PSP1 C-terminal conserved region
S101441_RS00225	COG4467	Involved in initiation control of chromosome replication
S101441_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S101441_RS00235	COG2827	Endonuclease containing a URI domain
S101441_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S101441_RS00245	COG2002	toxin-antitoxin pair type II binding
S101441_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101441_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101441_RS00255	COG0084	hydrolase, TatD family'
S101441_RS00260	COG3583	domain protein
S101441_RS00260	COG3584	3D domain protein
S101441_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101441_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101441_RS00285	COG4466	Protein conserved in bacteria
S101441_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101441_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101441_RS00305	COG0251	oxidation-reduction process
S101441_RS00310	COG2088	sporulation resulting in formation of a cellular spore
S101441_RS00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S101441_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101441_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S101441_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
S101441_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101441_RS00345	COG2002	toxin-antitoxin pair type II binding
S101441_RS00350	COG2244	polysaccharide biosynthetic process
S101441_RS00355	COG3956	TIGRFAM MazG family protein
S101441_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S101441_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S101441_RS00380	COG1098	S1 RNA binding domain
S101441_RS00395	COG2208	phosphoserine phosphatase activity
S101441_RS00400	COG2304	oxidoreductase activity
S101441_RS00410	COG0037	tRNA processing
S101441_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S101441_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101441_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S101441_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S101441_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101441_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101441_RS00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101441_RS00460	COG0512	Glutamine amidotransferase of anthranilate synthase
S101441_RS00465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101441_RS00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S101441_RS00475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S101441_RS00480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101441_RS00485	COG1396	sequence-specific DNA binding
S101441_RS00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101441_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S101441_RS00575	COG4463	regulation of RNA biosynthetic process
S101441_RS00580	COG3880	PFAM UvrB UvrC protein
S101441_RS00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S101441_RS00590	COG0542	response to heat
S101441_RS00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S101441_RS00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S101441_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
S101441_RS00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S101441_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S101441_RS00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101441_RS00630	COG1045	serine acetyltransferase
S101441_RS00635	COG0215	cysteine-tRNA ligase activity
S101441_RS00640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S101441_RS00645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101441_RS00650	COG3688	RNA-binding protein containing a PIN domain
S101441_RS00655	COG1595	DNA-templated transcription, initiation
S101441_RS00665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101441_RS00670	COG0250	Participates in transcription elongation, termination and antitermination
S101441_RS00680	COG0081	regulation of translation
S101441_RS00685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101441_RS00695	COG2813	Specifically methylates the guanine in position
S101441_RS00700	COG0085	RNA polymerase activity
S101441_RS00705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S101441_RS00710	COG1358	cellular component organization or biogenesis
S101441_RS00715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S101441_RS00720	COG0049	tRNA binding
S101441_RS00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101441_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S101441_RS00735	COG0596	Alpha beta hydrolase
S101441_RS00745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101441_RS00750	COG0088	Forms part of the polypeptide exit tunnel
S101441_RS00760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101441_RS00775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S101441_RS00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S101441_RS00790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101441_RS00795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S101441_RS00805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101441_RS00815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101441_RS00820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S101441_RS00825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101441_RS00830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101441_RS00840	COG0200	Binds to the 23S rRNA
S101441_RS00845	COG0201	protein transport
S101441_RS00850	COG0563	adenylate kinase activity
S101441_RS00855	COG0024	Methionine aminopeptidase
S101441_RS00860	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S101441_RS00870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101441_RS00875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101441_RS00880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101441_RS00885	COG0202	RNA polymerase activity
S101441_RS00890	COG0203	ribosomal protein L17
S101441_RS00895	COG1122	ATPase activity
S101441_RS00900	COG1122	ATPase activity
S101441_RS00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101441_RS00910	COG0101	tRNA pseudouridine synthase activity
S101441_RS00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S101441_RS00920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101441_RS00925	COG2226	methyltransferase
S101441_RS00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS00940	COG0489	protein tyrosine kinase activity
S101441_RS00950	COG2194	sulfuric ester hydrolase activity
S101441_RS00955	COG0726	polysaccharide deacetylase
S101441_RS01040	COG0659	secondary active sulfate transmembrane transporter activity
S101441_RS01045	COG0385	Bile acid
S101441_RS01050	COG2819	hydrolase of the alpha beta superfamily
S101441_RS01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS01070	COG2207	Transcriptional regulator
S101441_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
S101441_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101441_RS01090	COG1263	PTS System
S101441_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS01095	COG1737	Transcriptional regulator
S101441_RS01100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101441_RS01105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS01110	COG1683	Conserved Protein
S101441_RS01140	COG1595	DNA-templated transcription, initiation
S101441_RS01145	COG5662	AntiSigma factor
S101441_RS01150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101441_RS01155	COG4856	YbbR-like protein
S101441_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101441_RS01165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S101441_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS01175	COG0300	oxidoreductase activity
S101441_RS01175	COG3321	synthase
S101441_RS01175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS01195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101441_RS01200	COG3002	Belongs to the UPF0753 family
S101441_RS01205	COG0288	reversible hydration of carbon dioxide
S101441_RS01215	COG5609	conserved protein (DUF2294)
S101441_RS01220	COG0745	RESPONSE REGULATOR receiver
S101441_RS01235	COG0515	serine threonine protein kinase
S101441_RS01250	COG1113	amino acid transport
S101441_RS01270	COG2602	Beta-lactamase
S101441_RS01275	COG2124	cytochrome p450
S101441_RS01285	COG0531	amino acid
S101441_RS01290	COG0584	glycerophosphoryl diester phosphodiesterase
S101441_RS01295	COG2271	Major facilitator Superfamily
S101441_RS01310	COG1846	Transcriptional regulator
S101441_RS01310	COG0456	acetyltransferase
S101441_RS01330	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS01340	COG2207	Transcriptional regulator
S101441_RS01340	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS01365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S101441_RS01370	COG3591	Belongs to the peptidase S1B family
S101441_RS01380	COG0596	Alpha beta hydrolase
S101441_RS01385	COG1183	phosphatidylcholine synthase activity
S101441_RS01390	COG0586	Pfam SNARE associated Golgi protein
S101441_RS01395	COG0688	phosphatidylethanolamine metabolic process
S101441_RS01405	COG2312	Erythromycin esterase
S101441_RS01410	COG2207	Transcriptional regulator
S101441_RS01415	COG1054	Belongs to the UPF0176 family
S101441_RS01420	COG1301	dicarboxylic acid transport
S101441_RS01425	COG1263	PTS System
S101441_RS01425	COG2190	(PTS) system
S101441_RS01425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS01430	COG0363	glucosamine-6-phosphate deaminase activity
S101441_RS01435	COG2188	Transcriptional regulator
S101441_RS01445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101441_RS01450	COG0833	amino acid
S101441_RS01455	COG2040	homocysteine
S101441_RS01470	COG2066	Belongs to the glutaminase family
S101441_RS01475	COG4191	Histidine kinase
S101441_RS01480	COG0784	Response regulator, receiver
S101441_RS01490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101441_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS01500	COG2271	Major facilitator Superfamily
S101441_RS01505	COG4948	Mandelate Racemase Muconate Lactonizing
S101441_RS01510	COG2186	Transcriptional regulator
S101441_RS01515	COG2721	sulfolactate sulfo-lyase activity
S101441_RS01520	COG3173	Aminoglycoside phosphotransferase
S101441_RS01530	COG0697	spore germination
S101441_RS01535	COG0745	RESPONSE REGULATOR receiver
S101441_RS01540	COG2205	protein histidine kinase activity
S101441_RS01545	COG1131	(ABC) transporter
S101441_RS01560	COG3773	Cell wall hydrolase
S101441_RS01570	COG2304	oxidoreductase activity
S101441_RS01580	COG3540	Alkaline phosphatase
S101441_RS01585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101441_RS01590	COG0805	protein transport
S101441_RS01595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S101441_RS01600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101441_RS01605	COG0477	Major facilitator Superfamily
S101441_RS01610	COG1309	transcriptional regulator
S101441_RS01615	COG0252	asparaginase activity
S101441_RS01620	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101441_RS01625	COG1714	RDD family
S101441_RS01630	COG1405	negative regulation of cell septum assembly
S101441_RS01630	COG3012	SEC-C Motif Domain Protein
S101441_RS01635	COG3290	protein histidine kinase activity
S101441_RS01640	COG3279	Response regulator of the LytR AlgR family
S101441_RS01645	COG4555	ABC transporter
S101441_RS01650	COG1668	transmembrane transport
S101441_RS01665	COG1595	DNA-templated transcription, initiation
S101441_RS01675	COG1595	DNA-templated transcription, initiation
S101441_RS01680	COG1876	peptidase activity
S101441_RS01685	COG0457	Tetratricopeptide repeat
S101441_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS01695	COG0366	Alpha amylase catalytic
S101441_RS01700	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101441_RS01705	COG1121	(ABC) transporter
S101441_RS01710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101441_RS01730	COG2310	stress, protein
S101441_RS01735	COG2310	stress, protein
S101441_RS01740	COG2310	stress, protein
S101441_RS01745	COG0861	Integral membrane protein TerC family
S101441_RS01755	COG3853	Toxic anion resistance protein (TelA)
S101441_RS01760	COG0477	Major facilitator Superfamily
S101441_RS01770	COG2814	Major facilitator Superfamily
S101441_RS01775	COG1104	cysteine desulfurase activity
S101441_RS01820	COG0640	Transcriptional regulator
S101441_RS01825	COG4175	Glycine betaine
S101441_RS01825	COG0517	IMP dehydrogenase activity
S101441_RS01830	COG4176	ABC-type proline glycine betaine transport system permease component
S101441_RS01835	COG2113	Glycine betaine
S101441_RS01840	COG1473	amidohydrolase
S101441_RS01845	COG1288	antiporter activity
S101441_RS01860	COG0039	L-malate dehydrogenase activity
S101441_RS01865	COG1620	l-lactate permease
S101441_RS01870	COG2814	Major facilitator Superfamily
S101441_RS01875	COG3403	YqcI/YcgG family
S101441_RS01885	COG3665	Urea carboxylase-associated protein
S101441_RS01890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S101441_RS01895	COG1660	Displays ATPase and GTPase activities
S101441_RS01905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S101441_RS01910	COG2226	methyltransferase
S101441_RS01915	COG0583	DNA-binding transcription factor activity
S101441_RS01920	COG3458	cephalosporin-C deacetylase activity
S101441_RS01925	COG3541	Predicted nucleotidyltransferase
S101441_RS01930	COG0506	proline dehydrogenase activity
S101441_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS01940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101441_RS01945	COG2508	Transcriptional regulator
S101441_RS01950	COG3689	TIGRFAM TIGR03943 family protein
S101441_RS01955	COG0701	Predicted permease
S101441_RS01960	COG2267	carboxylic ester hydrolase activity
S101441_RS01965	COG0492	ferredoxin-NADP+ reductase activity
S101441_RS01970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101441_RS01970	COG1587	Uroporphyrinogen-III synthase
S101441_RS01975	COG2146	nitrite reductase [NAD(P)H] activity
S101441_RS01980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101441_RS01985	COG0243	molybdopterin cofactor binding
S101441_RS01990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101441_RS01995	COG2223	nitrite transmembrane transporter activity
S101441_RS02000	COG1469	GTP cyclohydrolase I activity
S101441_RS02005	COG1376	ErfK ybiS ycfS ynhG family protein
S101441_RS02020	COG0765	amino acid transport
S101441_RS02025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101441_RS02045	COG1846	Transcriptional regulator
S101441_RS02060	COG2723	6-phospho-beta-galactosidase activity
S101441_RS02070	COG3209	COG3209 Rhs family protein
S101441_RS02080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S101441_RS02085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S101441_RS02090	COG1733	regulation of RNA biosynthetic process
S101441_RS02095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS02100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS02105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS02110	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101441_RS02115	COG2814	Major facilitator Superfamily
S101441_RS02125	COG0697	spore germination
S101441_RS02135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS02145	COG2364	Membrane
S101441_RS02150	COG1126	abc transporter atp-binding protein
S101441_RS02155	COG0765	amino acid transport
S101441_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101441_RS02165	COG0583	DNA-binding transcription factor activity
S101441_RS02170	COG0163	prenyltransferase activity
S101441_RS02175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S101441_RS02190	COG0596	Alpha beta hydrolase
S101441_RS02195	COG3104	oligopeptide transport
S101441_RS02200	COG5434	Belongs to the glycosyl hydrolase 28 family
S101441_RS02215	COG0697	spore germination
S101441_RS02225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101441_RS02230	COG1136	(ABC) transporter
S101441_RS02235	COG0577	efflux transmembrane transporter activity
S101441_RS02240	COG0745	RESPONSE REGULATOR receiver
S101441_RS02245	COG3850	Histidine kinase
S101441_RS02245	COG5002	protein histidine kinase activity
S101441_RS02250	COG0457	Tetratricopeptide repeat
S101441_RS02270	COG0527	aspartate kinase activity
S101441_RS02275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS02280	COG4605	iron ion homeostasis
S101441_RS02285	COG4604	ABC transporter, ATP-binding protein
S101441_RS02290	COG4607	ABC-type enterochelin transport system periplasmic component
S101441_RS02295	COG2814	Major facilitator Superfamily
S101441_RS02300	COG1309	transcriptional regulator
S101441_RS02305	COG0778	Nitroreductase
S101441_RS02310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101441_RS02315	COG0640	Transcriptional regulator
S101441_RS02320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS02325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S101441_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS02335	COG4975	Glucose uptake
S101441_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS02345	COG4549	nuclear export factor GLE1
S101441_RS02350	COG2372	response to copper ion
S101441_RS02350	COG1276	copper resistance
S101441_RS02355	COG1349	DNA-binding transcription factor activity
S101441_RS02365	COG2213	PTS system mannitol-specific
S101441_RS02370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS02375	COG0246	Mannitol dehydrogenase
S101441_RS02380	COG0473	3-isopropylmalate dehydrogenase activity
S101441_RS02385	COG0681	Belongs to the peptidase S26 family
S101441_RS02395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101441_RS02410	COG0561	phosphatase activity
S101441_RS02415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S101441_RS02420	COG1914	H( )-stimulated, divalent metal cation uptake system
S101441_RS02425	COG4336	lyase activity
S101441_RS02430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S101441_RS02435	COG1984	allophanate hydrolase subunit 2
S101441_RS02440	COG1414	Transcriptional regulator
S101441_RS02445	COG2755	lipolytic protein G-D-S-L family
S101441_RS02455	COG2329	Antibiotic biosynthesis monooxygenase
S101441_RS02460	COG0768	penicillin binding
S101441_RS02465	COG4989	oxidoreductase activity
S101441_RS02470	COG3711	transcriptional antiterminator
S101441_RS02475	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS02480	COG2226	methyltransferase
S101441_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS02490	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS02495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS02500	COG3871	stress protein (general stress protein 26)
S101441_RS02510	COG2814	Major facilitator Superfamily
S101441_RS02515	COG1522	sequence-specific DNA binding
S101441_RS02520	COG0551	DNA topoisomerase type I activity
S101441_RS02520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101441_RS02525	COG0494	nUDIX hydrolase
S101441_RS02530	COG0028	Belongs to the TPP enzyme family
S101441_RS02555	COG1914	H( )-stimulated, divalent metal cation uptake system
S101441_RS02560	COG2261	transglycosylase associated protein
S101441_RS02565	COG4876	unkown
S101441_RS02570	COG2217	Heavy metal translocating P-type atpase
S101441_RS02575	COG3729	General stress protein
S101441_RS02580	COG0662	Cupin 2, conserved barrel domain protein
S101441_RS02585	COG2329	Antibiotic biosynthesis monooxygenase
S101441_RS02590	COG3546	catalase activity
S101441_RS02595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S101441_RS02600	COG3290	protein histidine kinase activity
S101441_RS02605	COG4565	transcriptional regulatory protein
S101441_RS02610	COG1301	dicarboxylic acid transport
S101441_RS02620	COG0628	permease
S101441_RS02625	COG1131	(ABC) transporter
S101441_RS02630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101441_RS02640	COG1960	acyl-CoA dehydrogenase activity
S101441_RS02655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101441_RS02660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS02665	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101441_RS02670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101441_RS02680	COG0513	Belongs to the DEAD box helicase family
S101441_RS02685	COG3402	PFAM membrane-flanked domain
S101441_RS02690	COG3428	Bacterial PH domain
S101441_RS02695	COG0705	Rhomboid family
S101441_RS02700	COG0736	holo-[acyl-carrier-protein] synthase activity
S101441_RS02705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S101441_RS02710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101441_RS02715	COG0864	Transcriptional regulator
S101441_RS02720	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101441_RS02725	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS02730	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS02735	COG2172	sigma factor antagonist activity
S101441_RS02740	COG2208	phosphoserine phosphatase activity
S101441_RS02745	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS02750	COG2172	sigma factor antagonist activity
S101441_RS02755	COG1191	sigma factor activity
S101441_RS02760	COG2208	phosphoserine phosphatase activity
S101441_RS02765	COG2183	response to ionizing radiation
S101441_RS02775	COG3091	SprT-like family
S101441_RS02820	COG0583	DNA-binding transcription factor activity
S101441_RS02825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS02835	COG5444	nuclease activity
S101441_RS02840	COG1476	TRANSCRIPTIONal
S101441_RS02865	COG0693	protein deglycase activity
S101441_RS02870	COG1278	Cold shock
S101441_RS02875	COG1329	Transcriptional regulator
S101441_RS02890	COG0697	spore germination
S101441_RS02895	COG2207	Transcriptional regulator
S101441_RS02895	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS02900	COG0697	spore germination
S101441_RS02905	COG3708	Transcriptional regulator
S101441_RS02905	COG2207	Transcriptional regulator
S101441_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS02915	COG0477	Major facilitator Superfamily
S101441_RS02920	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S101441_RS02935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS02940	COG1309	transcriptional regulator
S101441_RS02945	COG0697	spore germination
S101441_RS02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS02955	COG2030	dehydratase
S101441_RS02960	COG3545	Serine hydrolase
S101441_RS02965	COG1733	regulation of RNA biosynthetic process
S101441_RS02970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS02975	COG0640	Transcriptional regulator
S101441_RS02980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101441_RS02990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS02995	COG0697	spore germination
S101441_RS03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS03005	COG0076	glutamate decarboxylase activity
S101441_RS03010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101441_RS03015	COG0640	Transcriptional regulator
S101441_RS03035	COG4585	Histidine kinase
S101441_RS03040	COG2197	response regulator
S101441_RS03045	COG2409	Drug exporters of the RND superfamily
S101441_RS03055	COG0596	Alpha beta hydrolase
S101441_RS03060	COG1811	Na channel or pump
S101441_RS03065	COG4978	Transcriptional regulator
S101441_RS03065	COG0789	Transcriptional regulator
S101441_RS03070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101441_RS03075	COG0778	Nitroreductase
S101441_RS03080	COG0346	lactoylglutathione lyase activity
S101441_RS03085	COG2259	Doxx family
S101441_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS03105	COG2323	membrane
S101441_RS03110	COG2323	membrane
S101441_RS03115	COG0071	Belongs to the small heat shock protein (HSP20) family
S101441_RS03130	COG1309	transcriptional regulator
S101441_RS03140	COG0456	acetyltransferase
S101441_RS03150	COG1113	amino acid transport
S101441_RS03155	COG2318	DinB family
S101441_RS03160	COG1846	Transcriptional regulator
S101441_RS03165	COG2409	Drug exporters of the RND superfamily
S101441_RS03165	COG1033	growth of symbiont in host cell
S101441_RS03170	COG0778	Nitroreductase
S101441_RS03175	COG1846	Transcriptional regulator
S101441_RS03180	COG2814	Major facilitator Superfamily
S101441_RS03185	COG0730	response to heat
S101441_RS03190	COG1802	Transcriptional regulator
S101441_RS03195	COG1388	LysM domain
S101441_RS03195	COG3858	chitin binding
S101441_RS03200	COG1819	glycosyl
S101441_RS03210	COG1785	Belongs to the alkaline phosphatase family
S101441_RS03215	COG5646	InterPro IPR014922
S101441_RS03225	COG0454	-acetyltransferase
S101441_RS03230	COG1078	dGTPase activity
S101441_RS03235	COG1388	LysM domain
S101441_RS03240	COG2814	Major facilitator Superfamily
S101441_RS03245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101441_RS03260	COG2723	6-phospho-beta-galactosidase activity
S101441_RS03265	COG2188	Transcriptional regulator
S101441_RS03270	COG1940	carbohydrate kinase activity
S101441_RS03280	COG4124	Belongs to the glycosyl hydrolase 26 family
S101441_RS03325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S101441_RS03330	COG0802	atpase or kinase
S101441_RS03335	COG1214	PFAM Peptidase M22, glycoprotease
S101441_RS03340	COG0456	acetyltransferase
S101441_RS03345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101441_RS03350	COG0488	(ABC) transporter
S101441_RS03355	COG0315	cyclic pyranopterin monophosphate synthase activity
S101441_RS03360	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S101441_RS03365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101441_RS03370	COG0805	protein transport
S101441_RS03385	COG1266	CAAX protease self-immunity
S101441_RS03395	COG0459	protein refolding
S101441_RS03400	COG4974	Belongs to the 'phage' integrase family
S101441_RS03405	COG2856	Zn peptidase
S101441_RS03410	COG1396	sequence-specific DNA binding
S101441_RS03470	COG3935	DnaD domain protein
S101441_RS03475	COG1484	DNA-dependent DNA replication
S101441_RS03485	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S101441_RS03525	COG3677	Transposase
S101441_RS03615	COG5280	Phage tail tape measure protein TP901
S101441_RS03615	COG3953	SLT domain
S101441_RS03625	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101441_RS03660	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS03660	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS03660	COG1388	LysM domain
S101441_RS03670	COG5444	nuclease activity
S101441_RS03720	COG0457	Tetratricopeptide repeat
S101441_RS03725	COG1063	alcohol dehydrogenase
S101441_RS03730	COG2211	Major facilitator Superfamily
S101441_RS03735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101441_RS03740	COG1842	Phage shock protein A
S101441_RS03745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101441_RS03750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S101441_RS03755	COG4260	virion core protein, lumpy skin disease virus
S101441_RS03765	COG2814	Major facilitator Superfamily
S101441_RS03770	COG1063	alcohol dehydrogenase
S101441_RS03775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S101441_RS03780	COG0823	Involved in the tonB-independent uptake of proteins
S101441_RS03800	COG2267	carboxylic ester hydrolase activity
S101441_RS03810	COG2132	Multicopper oxidase
S101441_RS03815	COG1113	amino acid transport
S101441_RS03825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101441_RS03830	COG0714	Associated with various cellular activities
S101441_RS03835	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S101441_RS03840	COG1305	Transglutaminase-like
S101441_RS03845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S101441_RS03845	COG0519	Catalyzes the synthesis of GMP from XMP
S101441_RS03860	COG2252	PERMEase
S101441_RS03865	COG3064	Membrane
S101441_RS03880	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S101441_RS03890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S101441_RS03895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101441_RS03900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101441_RS03905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S101441_RS03910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101441_RS03915	COG0047	phosphoribosylformylglycinamidine synthase activity
S101441_RS03920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101441_RS03925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S101441_RS03930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S101441_RS03935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S101441_RS03940	COG0138	bifunctional purine biosynthesis protein purh
S101441_RS03945	COG0151	Belongs to the GarS family
S101441_RS03950	COG1522	sequence-specific DNA binding
S101441_RS03965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101441_RS03970	COG1470	cell adhesion involved in biofilm formation
S101441_RS03975	COG4496	protein, YerC YecD
S101441_RS03980	COG0069	glutamate synthase activity
S101441_RS03985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S101441_RS03990	COG0210	DNA helicase
S101441_RS03995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101441_RS04000	COG4851	CamS sex pheromone cAM373 precursor
S101441_RS04005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101441_RS04010	COG1285	pathogenesis
S101441_RS04015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101441_RS04020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101441_RS04025	COG0154	amidase activity
S101441_RS04030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101441_RS04035	COG1309	transcriptional regulator
S101441_RS04040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S101441_RS04045	COG1597	lipid kinase activity
S101441_RS04055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101441_RS04080	COG0457	Tetratricopeptide repeat
S101441_RS04100	COG5444	nuclease activity
S101441_RS04110	COG3586	endonuclease activity
S101441_RS04120	COG0457	Tetratricopeptide repeat
S101441_RS04130	COG0217	transcriptional regulatory protein
S101441_RS04140	COG1309	transcriptional regulator
S101441_RS04145	COG3631	Ketosteroid isomerase-related protein
S101441_RS04165	COG3546	catalase activity
S101441_RS04170	COG0454	-acetyltransferase
S101441_RS04180	COG5578	integral membrane protein
S101441_RS04185	COG2972	Histidine kinase
S101441_RS04195	COG1653	transport
S101441_RS04205	COG0395	ABC-type sugar transport system, permease component
S101441_RS04210	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101441_RS04215	COG2207	Transcriptional regulator
S101441_RS04220	COG2755	lipolytic protein G-D-S-L family
S101441_RS04230	COG5578	integral membrane protein
S101441_RS04240	COG3401	FG-GAP repeat protein
S101441_RS04245	COG2755	lipolytic protein G-D-S-L family
S101441_RS04250	COG1874	Beta-galactosidase
S101441_RS04260	COG1653	transport
S101441_RS04265	COG4209	transmembrane transport
S101441_RS04270	COG0395	ABC-type sugar transport system, permease component
S101441_RS04275	COG1486	melibiose metabolic process
S101441_RS04280	COG2323	membrane
S101441_RS04285	COG2329	Antibiotic biosynthesis monooxygenase
S101441_RS04290	COG0346	lactoylglutathione lyase activity
S101441_RS04305	COG5583	Uncharacterized small protein (DUF2292)
S101441_RS04310	COG0670	Belongs to the BI1 family
S101441_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101441_RS04320	COG1715	Restriction endonuclease
S101441_RS04330	COG2124	cytochrome p450
S101441_RS04330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101441_RS04335	COG1368	sulfuric ester hydrolase activity
S101441_RS04340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S101441_RS04345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101441_RS04350	COG1442	glycosyl transferase family 8
S101441_RS04355	COG1216	Glycosyl transferase, family 2
S101441_RS04360	COG1442	glycosyl transferase family 8
S101441_RS04365	COG2223	nitrite transmembrane transporter activity
S101441_RS04370	COG1011	Hydrolase
S101441_RS04375	COG0531	amino acid
S101441_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS04385	COG0840	transmembrane signaling receptor activity
S101441_RS04390	COG0488	(ABC) transporter
S101441_RS04400	COG0789	Transcriptional regulator
S101441_RS04405	COG2814	Major facilitator Superfamily
S101441_RS04420	COG0488	(ABC) transporter
S101441_RS04425	COG0513	Belongs to the DEAD box helicase family
S101441_RS04430	COG0456	acetyltransferase
S101441_RS04435	COG3328	transposase activity
S101441_RS04440	COG2130	NADP-dependent
S101441_RS04445	COG1120	ATPase activity
S101441_RS04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS04460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101441_RS04480	COG3866	Pectate lyase
S101441_RS04485	COG0471	metal ion transport
S101441_RS04490	COG3290	protein histidine kinase activity
S101441_RS04495	COG4565	transcriptional regulatory protein
S101441_RS04500	COG3181	Tripartite tricarboxylate transporter family receptor
S101441_RS04515	COG2851	Citrate transporter
S101441_RS04520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS04525	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S101441_RS04530	COG1254	Belongs to the acylphosphatase family
S101441_RS04535	COG2258	MOSC domain
S101441_RS04555	COG0024	Methionine aminopeptidase
S101441_RS04560	COG1263	PTS System
S101441_RS04560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS04565	COG1368	sulfuric ester hydrolase activity
S101441_RS04580	COG1115	amino acid carrier protein
S101441_RS04585	COG0697	spore germination
S101441_RS04590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS04590	COG1263	PTS System
S101441_RS04595	COG0366	Alpha amylase catalytic
S101441_RS04600	COG2188	Transcriptional regulator
S101441_RS04605	COG0778	Nitroreductase
S101441_RS04610	COG0737	Belongs to the 5'-nucleotidase family
S101441_RS04615	COG0693	protein deglycase activity
S101441_RS04620	COG2814	Major facilitator Superfamily
S101441_RS04625	COG4840	Belongs to the UPF0435 family
S101441_RS04630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101441_RS04635	COG4980	gas vesicle protein
S101441_RS04640	COG1295	ribonuclease BN
S101441_RS04645	COG0477	Major facilitator Superfamily
S101441_RS04650	COG0387	Pfam Sodium calcium exchanger
S101441_RS04660	COG0668	transmembrane transport
S101441_RS04665	COG0535	radical SAM domain protein
S101441_RS04675	COG0726	polysaccharide deacetylase
S101441_RS04680	COG2084	Dehydrogenase
S101441_RS04685	COG0598	Magnesium transport protein CorA
S101441_RS04690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S101441_RS04695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101441_RS04705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101441_RS04710	COG4637	Psort location Cytoplasmic, score
S101441_RS04720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101441_RS04725	COG0022	dehydrogenase e1 component
S101441_RS04730	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101441_RS04735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101441_RS04740	COG3284	Transcriptional regulator
S101441_RS04750	COG1742	UPF0060 membrane protein
S101441_RS04775	COG4842	Belongs to the WXG100 family
S101441_RS04780	COG1486	melibiose metabolic process
S101441_RS04785	COG1737	Transcriptional regulator
S101441_RS04790	COG1263	PTS System
S101441_RS04790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS04795	COG1132	(ABC) transporter
S101441_RS04800	COG1132	(ABC) transporter
S101441_RS04805	COG2259	Doxx family
S101441_RS04810	COG2514	catechol 2,3-dioxygenase activity
S101441_RS04815	COG4585	Histidine kinase
S101441_RS04820	COG2197	response regulator
S101441_RS04825	COG1131	(ABC) transporter
S101441_RS04830	COG1511	domain protein
S101441_RS04830	COG0842	Transport permease protein
S101441_RS04835	COG0842	Transport permease protein
S101441_RS04840	COG1695	Transcriptional regulator
S101441_RS04845	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101441_RS04850	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S101441_RS04855	COG1309	transcriptional regulator
S101441_RS04860	COG2814	Major facilitator Superfamily
S101441_RS04865	COG2318	DinB family
S101441_RS04875	COG1846	Transcriptional regulator
S101441_RS04880	COG0392	lysyltransferase activity
S101441_RS04880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S101441_RS04885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS04890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS04900	COG0384	phenazine biosynthesis protein PhzF
S101441_RS04905	COG0778	Nitroreductase
S101441_RS04920	COG1090	epimerase
S101441_RS04925	COG2137	regulation of response to DNA damage stimulus
S101441_RS04935	COG2814	Major facilitator Superfamily
S101441_RS04950	COG3103	Sh3 type 3 domain protein
S101441_RS04955	COG5658	integral membrane protein
S101441_RS04960	COG0596	Alpha beta hydrolase
S101441_RS04965	COG0463	Glycosyl transferase, family 2
S101441_RS04970	COG4485	Bacterial membrane protein, YfhO
S101441_RS04975	COG1988	membrane-bound metal-dependent
S101441_RS04980	COG1194	a g-specific adenine glycosylase
S101441_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS05005	COG3557	Belongs to the UPF0374 family
S101441_RS05010	COG1132	(ABC) transporter
S101441_RS05015	COG4129	membrane
S101441_RS05020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101441_RS05025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101441_RS05030	COG0735	belongs to the Fur family
S101441_RS05155	COG4326	sporulation control protein
S101441_RS05165	COG5577	PFAM Coat F domain
S101441_RS05170	COG3340	Belongs to the peptidase S51 family
S101441_RS05175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S101441_RS05190	COG0753	catalase activity
S101441_RS05195	COG1116	anion transmembrane transporter activity
S101441_RS05200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101441_RS05205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101441_RS05210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101441_RS05220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101441_RS05230	COG1476	TRANSCRIPTIONal
S101441_RS05240	COG3382	B3 4 domain protein
S101441_RS05245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S101441_RS05255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S101441_RS05260	COG0789	Transcriptional regulator
S101441_RS05265	COG1664	Polymer-forming cytoskeletal
S101441_RS05270	COG1664	Polymer-forming cytoskeletal
S101441_RS05275	COG2766	serine protein kinase
S101441_RS05280	COG2718	Belongs to the UPF0229 family
S101441_RS05285	COG1846	Transcriptional regulator
S101441_RS05290	COG1566	PFAM secretion protein HlyD family protein
S101441_RS05295	COG2814	Major facilitator Superfamily
S101441_RS05300	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101441_RS05320	COG1725	Transcriptional regulator
S101441_RS05325	COG1131	(ABC) transporter
S101441_RS05330	COG1131	(ABC) transporter
S101441_RS05335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101441_RS05340	COG1278	Cold shock
S101441_RS05350	COG1464	Belongs to the NlpA lipoprotein family
S101441_RS05355	COG3706	GGDEF domain
S101441_RS05360	COG1823	symporter activity
S101441_RS05365	COG5444	nuclease activity
S101441_RS05390	COG0582	viral genome integration into host DNA
S101441_RS05395	COG2946	Replication initiation factor
S101441_RS05445	COG5644	endopeptidase inhibitor activity
S101441_RS05450	COG0791	NLP P60 protein
S101441_RS05450	COG0741	lytic transglycosylase activity
S101441_RS05470	COG0457	Tetratricopeptide repeat
S101441_RS05495	COG5577	PFAM Coat F domain
S101441_RS05500	COG0737	Belongs to the 5'-nucleotidase family
S101441_RS05500	COG4085	toxin activity
S101441_RS05500	COG1525	nuclease
S101441_RS05505	COG3764	Sortase (surface protein transpeptidase)
S101441_RS05510	COG0564	pseudouridine synthase activity
S101441_RS05520	COG0517	IMP dehydrogenase activity
S101441_RS05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101441_RS05530	COG3153	acetyltransferase
S101441_RS05530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101441_RS05535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101441_RS05540	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S101441_RS05545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101441_RS05550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101441_RS05555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S101441_RS05560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101441_RS05565	COG2203	Gaf domain
S101441_RS05565	COG4585	Histidine kinase
S101441_RS05570	COG2197	response regulator
S101441_RS05575	COG0431	NADPH-dependent FMN reductase
S101441_RS05590	COG0791	NLP P60 protein
S101441_RS05590	COG1388	LysM domain
S101441_RS05595	COG1959	2 iron, 2 sulfur cluster binding
S101441_RS05605	COG0668	transmembrane transport
S101441_RS05610	COG2719	SpoVR family
S101441_RS05615	COG1785	Belongs to the alkaline phosphatase family
S101441_RS05620	COG0791	NLP P60 protein
S101441_RS05620	COG1388	LysM domain
S101441_RS05625	COG0583	DNA-binding transcription factor activity
S101441_RS05630	COG0372	Belongs to the citrate synthase family
S101441_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS05640	COG0531	amino acid
S101441_RS05645	COG0733	neurotransmitter:sodium symporter activity
S101441_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS05655	COG0456	acetyltransferase
S101441_RS05670	COG1595	DNA-templated transcription, initiation
S101441_RS05675	COG0667	Aldo Keto reductase
S101441_RS05680	COG0204	Acyl-transferase
S101441_RS05685	COG1253	flavin adenine dinucleotide binding
S101441_RS05690	COG0789	Transcriptional regulator
S101441_RS05700	COG1253	flavin adenine dinucleotide binding
S101441_RS05705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101441_RS05710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101441_RS05715	COG0584	glycerophosphoryl diester phosphodiesterase
S101441_RS05725	COG0668	transmembrane transport
S101441_RS05730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S101441_RS05735	COG0726	polysaccharide deacetylase
S101441_RS05740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101441_RS05745	COG1757	Na H antiporter
S101441_RS05750	COG0589	response to stress
S101441_RS05760	COG1132	(ABC) transporter
S101441_RS05765	COG1132	(ABC) transporter
S101441_RS05770	COG0702	epimerase
S101441_RS05790	COG0189	ligase activity
S101441_RS05795	COG0189	ligase activity
S101441_RS05800	COG4399	Belongs to the UPF0754 family
S101441_RS05805	COG3679	Belongs to the UPF0342 family
S101441_RS05815	COG0561	phosphatase activity
S101441_RS05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101441_RS05825	COG0475	glutathione-regulated potassium exporter activity
S101441_RS05830	COG0490	domain, Protein
S101441_RS05840	COG1024	Enoyl-CoA hydratase
S101441_RS05850	COG4152	abc transporter atp-binding protein
S101441_RS05855	COG1668	transmembrane transport
S101441_RS05860	COG0420	3'-5' exonuclease activity
S101441_RS05865	COG4717	serine-type aminopeptidase activity
S101441_RS05870	COG3481	metal-dependent phosphohydrolase, HD sub domain
S101441_RS05880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101441_RS05910	COG1846	Transcriptional regulator
S101441_RS05915	COG4980	gas vesicle protein
S101441_RS05930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S101441_RS05935	COG0537	adenosine 5'-monophosphoramidase activity
S101441_RS05940	COG1131	(ABC) transporter
S101441_RS05945	COG4473	ABC transporter
S101441_RS05955	COG1473	amidohydrolase
S101441_RS05960	COG3069	C4-dicarboxylate transmembrane transporter activity
S101441_RS05970	COG2329	Antibiotic biosynthesis monooxygenase
S101441_RS05975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101441_RS05980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S101441_RS05985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101441_RS05990	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S101441_RS05995	COG1309	transcriptional regulator
S101441_RS06000	COG1511	domain protein
S101441_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101441_RS06020	COG4377	Putative membrane peptidase family (DUF2324)
S101441_RS06030	COG1363	Peptidase, m42
S101441_RS06035	COG4405	Protein conserved in bacteria
S101441_RS06040	COG1301	dicarboxylic acid transport
S101441_RS06050	COG1234	tRNA 3'-trailer cleavage
S101441_RS06055	COG0095	Lipoate-protein ligase
S101441_RS06060	COG0702	epimerase
S101441_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS06080	COG0501	Belongs to the peptidase M48B family
S101441_RS06090	COG0456	acetyltransferase
S101441_RS06095	COG0604	alcohol dehydrogenase
S101441_RS06100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101441_RS06110	COG0406	alpha-ribazole phosphatase activity
S101441_RS06115	COG0183	Belongs to the thiolase family
S101441_RS06120	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS06125	COG1268	BioY protein
S101441_RS06130	COG0840	transmembrane signaling receptor activity
S101441_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS06150	COG4903	ComK protein
S101441_RS06155	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS06165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101441_RS06180	COG0398	Pfam SNARE associated Golgi protein
S101441_RS06185	COG0681	Belongs to the peptidase S26 family
S101441_RS06190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101441_RS06195	COG1846	Transcriptional regulator
S101441_RS06210	COG0738	Major facilitator superfamily
S101441_RS06215	COG0673	inositol 2-dehydrogenase activity
S101441_RS06220	COG0561	phosphatase activity
S101441_RS06225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101441_RS06230	COG1609	Transcriptional regulator
S101441_RS06235	COG3180	Ammonia monooxygenase
S101441_RS06240	COG0477	Major facilitator Superfamily
S101441_RS06240	COG2814	Major facilitator Superfamily
S101441_RS06245	COG4533	DNA binding
S101441_RS06255	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S101441_RS06260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S101441_RS06265	COG1074	ATP-dependent DNA helicase activity
S101441_RS06270	COG0420	3'-5' exonuclease activity
S101441_RS06275	COG0419	ATPase involved in DNA repair
S101441_RS06280	COG1403	HNH endonuclease
S101441_RS06320	COG5337	Spore coat protein CotH
S101441_RS06325	COG0179	Fumarylacetoacetate (FAA) hydrolase
S101441_RS06335	COG1404	Belongs to the peptidase S8 family
S101441_RS06350	COG0367	asparagine synthase
S101441_RS06360	COG0534	Mate efflux family protein
S101441_RS06365	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS06365	COG2207	Transcriptional regulator
S101441_RS06370	COG1609	Transcriptional regulator
S101441_RS06375	COG0673	inositol 2-dehydrogenase activity
S101441_RS06380	COG2318	DinB family
S101441_RS06385	COG1279	arginine transmembrane transporter activity
S101441_RS06390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101441_RS06395	COG1357	PFAM Pentapeptide repeats (8 copies)
S101441_RS06400	COG2267	carboxylic ester hydrolase activity
S101441_RS06405	COG0454	-acetyltransferase
S101441_RS06410	COG2153	protein acetylation
S101441_RS06415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S101441_RS06415	COG0646	methionine synthase
S101441_RS06420	COG1666	GTP binding
S101441_RS06425	COG2996	Protein conserved in bacteria
S101441_RS06445	COG1695	Transcriptional regulator
S101441_RS06460	COG3227	Zinc metalloprotease (Elastase)
S101441_RS06465	COG1307	EDD domain protein, DegV family
S101441_RS06470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS06485	COG0561	phosphatase activity
S101441_RS06490	COG1073	alpha beta
S101441_RS06495	COG2151	metal-sulfur cluster biosynthetic enzyme
S101441_RS06505	COG0277	FAD linked oxidase domain protein
S101441_RS06515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S101441_RS06520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S101441_RS06530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101441_RS06535	COG0505	Belongs to the CarA family
S101441_RS06540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101441_RS06545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101441_RS06565	COG2267	carboxylic ester hydrolase activity
S101441_RS06575	COG1744	ABC transporter substrate-binding protein PnrA-like
S101441_RS06590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101441_RS06595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101441_RS06600	COG5504	Zn-dependent protease
S101441_RS06605	COG0444	Belongs to the ABC transporter superfamily
S101441_RS06610	COG4608	Belongs to the ABC transporter superfamily
S101441_RS06620	COG0601	transmembrane transport
S101441_RS06625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101441_RS06635	COG0180	Tryptophanyl-tRNA synthetase
S101441_RS06640	COG4166	transmembrane transport
S101441_RS06645	COG0601	transmembrane transport
S101441_RS06650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101441_RS06655	COG0444	Belongs to the ABC transporter superfamily
S101441_RS06660	COG4608	Belongs to the ABC transporter superfamily
S101441_RS06665	COG2814	Major facilitator Superfamily
S101441_RS06675	COG1393	Belongs to the ArsC family
S101441_RS06680	COG0861	Integral membrane protein TerC family
S101441_RS06685	COG4862	establishment of competence for transformation
S101441_RS06690	COG4469	Competence protein
S101441_RS06695	COG1164	Oligoendopeptidase f
S101441_RS06710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101441_RS06715	COG2346	COG2346, Truncated hemoglobins
S101441_RS06720	COG0741	lytic transglycosylase activity
S101441_RS06725	COG4116	CYTH
S101441_RS06735	COG2357	RelA SpoT domain protein
S101441_RS06740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101441_RS06745	COG0564	pseudouridine synthase activity
S101441_RS06750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S101441_RS06755	COG0475	glutathione-regulated potassium exporter activity
S101441_RS06755	COG0569	domain protein
S101441_RS06760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101441_RS06765	COG0352	thiamine-phosphate diphosphorylase activity
S101441_RS06770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101441_RS06775	COG2104	thiamine diphosphate biosynthetic process
S101441_RS06780	COG2022	thiamine diphosphate biosynthetic process
S101441_RS06785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101441_RS06790	COG0351	phosphomethylpyrimidine kinase
S101441_RS06795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101441_RS06850	COG0210	DNA helicase
S101441_RS06860	COG2153	protein acetylation
S101441_RS06865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101441_RS06870	COG2382	esterase
S101441_RS06875	COG0626	cystathionine gamma-synthase activity
S101441_RS06880	COG0626	cystathionine gamma-synthase activity
S101441_RS06885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS06890	COG5505	Protein of unknown function (DUF819)
S101441_RS06925	COG1396	sequence-specific DNA binding
S101441_RS07055	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101441_RS07065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS07065	COG3711	transcriptional antiterminator
S101441_RS07070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS07070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101441_RS07070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101441_RS07075	COG1482	cell wall glycoprotein biosynthetic process
S101441_RS07090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS07100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S101441_RS07120	COG0109	protoheme IX farnesyltransferase activity
S101441_RS07130	COG0726	polysaccharide deacetylase
S101441_RS07150	COG2205	protein histidine kinase activity
S101441_RS07160	COG3383	formate dehydrogenase (NAD+) activity
S101441_RS07165	COG2427	Protein of unknown function (DUF1641)
S101441_RS07175	COG1051	belongs to the nudix hydrolase family
S101441_RS07185	COG2124	cytochrome p450
S101441_RS07190	COG1819	glycosyl
S101441_RS07200	COG1587	Uroporphyrinogen-III synthase
S101441_RS07210	COG0390	transport system, permease component
S101441_RS07215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101441_RS07220	COG0697	spore germination
S101441_RS07235	COG1252	NADH dehydrogenase
S101441_RS07240	COG1904	glucuronate isomerase
S101441_RS07250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S101441_RS07255	COG1063	alcohol dehydrogenase
S101441_RS07260	COG1312	Catalyzes the dehydration of D-mannonate
S101441_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS07270	COG2271	Major facilitator Superfamily
S101441_RS07275	COG1609	Transcriptional regulator
S101441_RS07280	COG0246	Mannitol dehydrogenase
S101441_RS07285	COG2721	sulfolactate sulfo-lyase activity
S101441_RS07290	COG0730	response to heat
S101441_RS07300	COG2318	DinB family
S101441_RS07305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101441_RS07315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101441_RS07320	COG0457	Tetratricopeptide repeat
S101441_RS07335	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS07335	COG1388	LysM domain
S101441_RS07335	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS07345	COG4195	phage-related replication protein
S101441_RS07350	COG3546	catalase activity
S101441_RS07355	COG2856	Zn peptidase
S101441_RS07360	COG1396	sequence-specific DNA binding
S101441_RS07370	COG1522	sequence-specific DNA binding
S101441_RS07375	COG1484	DNA-dependent DNA replication
S101441_RS07395	COG1595	DNA-templated transcription, initiation
S101441_RS07400	COG3728	DNA packaging
S101441_RS07400	COG5484	DNA packaging
S101441_RS07405	COG1783	phage Terminase large subunit
S101441_RS07410	COG5518	Phage portal protein
S101441_RS07415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S101441_RS07420	COG4653	Phage capsid family
S101441_RS07470	COG3953	SLT domain
S101441_RS07470	COG3953	SLT domain
S101441_RS07470	COG5412	phage tail tape measure protein
S101441_RS07470	COG5412	phage tail tape measure protein
S101441_RS07470	COG3953	SLT domain
S101441_RS07470	COG5412	phage tail tape measure protein
S101441_RS07475	COG1652	LysM domain
S101441_RS07480	COG4193	domain, Protein
S101441_RS07490	COG3628	GPW Gp25 family protein
S101441_RS07495	COG3299	homolog of phage Mu protein gp47
S101441_RS07500	COG3778	Protein conserved in bacteria
S101441_RS07540	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS07540	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS07555	COG0306	phosphate transporter
S101441_RS07560	COG1392	Phosphate transport regulator
S101441_RS07570	COG0531	amino acid
S101441_RS07575	COG0346	lactoylglutathione lyase activity
S101441_RS07580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101441_RS07585	COG0463	Glycosyl transferase, family 2
S101441_RS07590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101441_RS07595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101441_RS07600	COG2362	D-Aminopeptidase
S101441_RS07605	COG0601	transmembrane transport
S101441_RS07610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101441_RS07615	COG0444	Belongs to the ABC transporter superfamily
S101441_RS07620	COG4166	transmembrane transport
S101441_RS07625	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101441_RS07630	COG4948	Mandelate Racemase Muconate Lactonizing
S101441_RS07635	COG0791	NLP P60 protein
S101441_RS07640	COG4608	Belongs to the ABC transporter superfamily
S101441_RS07645	COG2706	6-phosphogluconolactonase activity
S101441_RS07655	COG1607	acyl-coa hydrolase
S101441_RS07660	COG1017	nitric oxide dioxygenase activity
S101441_RS07660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101441_RS07670	COG2323	membrane
S101441_RS07675	COG2318	DinB family
S101441_RS07680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS07685	COG2076	Multidrug Resistance protein
S101441_RS07690	COG2076	Multidrug Resistance protein
S101441_RS07695	COG0788	formyltetrahydrofolate deformylase activity
S101441_RS07700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101441_RS07705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101441_RS07710	COG1764	response to oxidative stress
S101441_RS07715	COG1846	Transcriptional regulator
S101441_RS07720	COG1764	response to oxidative stress
S101441_RS07730	COG0590	tRNA wobble adenosine to inosine editing
S101441_RS07735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101441_RS07740	COG1404	Belongs to the peptidase S8 family
S101441_RS07745	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS07750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101441_RS07755	COG1122	ATPase activity
S101441_RS07760	COG4721	ABC-type cobalt transport system, permease component
S101441_RS07770	COG0745	RESPONSE REGULATOR receiver
S101441_RS07775	COG5002	protein histidine kinase activity
S101441_RS07775	COG3850	Histidine kinase
S101441_RS07780	COG3212	peptidase
S101441_RS07785	COG3212	peptidase
S101441_RS07800	COG2239	Acts as a magnesium transporter
S101441_RS07805	COG0789	Transcriptional regulator
S101441_RS07820	COG1846	Transcriptional regulator
S101441_RS07825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101441_RS07830	COG0726	polysaccharide deacetylase
S101441_RS07835	COG1408	metallophosphoesterase
S101441_RS07845	COG0463	Glycosyl transferase, family 2
S101441_RS07850	COG1793	dna ligase
S101441_RS07850	COG3285	dna ligase
S101441_RS07855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S101441_RS07860	COG3300	MHYT domain
S101441_RS07860	COG5001	Diguanylate cyclase
S101441_RS07865	COG0586	Pfam SNARE associated Golgi protein
S101441_RS07870	COG0861	Integral membrane protein TerC family
S101441_RS07875	COG1191	sigma factor activity
S101441_RS07895	COG0501	Belongs to the peptidase M48B family
S101441_RS07900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101441_RS07915	COG3594	Acyltransferase
S101441_RS07920	COG5002	protein histidine kinase activity
S101441_RS07925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101441_RS07930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S101441_RS07935	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S101441_RS07940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101441_RS07945	COG0436	Aminotransferase
S101441_RS07950	COG1850	ribulose-bisphosphate carboxylase activity
S101441_RS07955	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S101441_RS07960	COG0235	Class ii aldolase
S101441_RS07965	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S101441_RS07970	COG3339	Conserved Protein
S101441_RS07985	COG3852	Histidine kinase
S101441_RS07990	COG1846	Transcriptional regulator
S101441_RS07995	COG1360	Flagellar Motor Protein
S101441_RS08000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101441_RS08005	COG0542	response to heat
S101441_RS08010	COG3949	Membrane
S101441_RS08015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101441_RS08020	COG0720	synthase
S101441_RS08025	COG0602	queuosine metabolic process
S101441_RS08030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101441_RS08040	COG4873	Protein conserved in bacteria
S101441_RS08050	COG3773	Cell wall hydrolase
S101441_RS08055	COG2244	polysaccharide biosynthetic process
S101441_RS08060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS08065	COG2217	Heavy metal translocating P-type atpase
S101441_RS08075	COG0006	proline dipeptidase activity
S101441_RS08080	COG1609	Transcriptional regulator
S101441_RS08085	COG3711	transcriptional antiterminator
S101441_RS08090	COG1263	PTS System
S101441_RS08090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS08090	COG2190	(PTS) system
S101441_RS08095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS08100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101441_RS08110	COG1533	DNA photolyase activity
S101441_RS08115	COG0456	acetyltransferase
S101441_RS08120	COG0840	transmembrane signaling receptor activity
S101441_RS08125	COG2084	Dehydrogenase
S101441_RS08140	COG3328	transposase activity
S101441_RS08145	COG2340	Cysteine-rich secretory protein family
S101441_RS08150	COG0768	penicillin binding
S101441_RS08155	COG4191	Histidine kinase
S101441_RS08160	COG0436	Aminotransferase
S101441_RS08170	COG0835	chemotaxis
S101441_RS08170	COG0784	Response regulator, receiver
S101441_RS08180	COG2814	Major facilitator Superfamily
S101441_RS08185	COG1376	ErfK ybiS ycfS ynhG family protein
S101441_RS08190	COG1408	metallophosphoesterase
S101441_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS08200	COG2200	EAL domain
S101441_RS08205	COG4703	Protein of unknown function (DUF1797)
S101441_RS08210	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S101441_RS08220	COG0517	IMP dehydrogenase activity
S101441_RS08225	COG0583	DNA-binding transcription factor activity
S101441_RS08230	COG0716	FMN binding
S101441_RS08240	COG0716	FMN binding
S101441_RS08245	COG2171	N-acyltransferase activity
S101441_RS08250	COG1473	amidohydrolase
S101441_RS08260	COG0668	transmembrane transport
S101441_RS08265	COG0450	alkyl hydroperoxide reductase
S101441_RS08270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS08290	COG0746	molybdenum cofactor guanylyltransferase activity
S101441_RS08295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101441_RS08300	COG0303	'Molybdopterin
S101441_RS08305	COG1763	Mo-molybdopterin cofactor biosynthetic process
S101441_RS08310	COG0314	molybdopterin synthase activity
S101441_RS08315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S101441_RS08320	COG1132	(ABC) transporter
S101441_RS08325	COG1132	(ABC) transporter
S101441_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101441_RS08340	COG1136	(ABC) transporter
S101441_RS08345	COG0577	efflux transmembrane transporter activity
S101441_RS08350	COG1349	DNA-binding transcription factor activity
S101441_RS08355	COG1105	Belongs to the carbohydrate kinase PfkB family
S101441_RS08360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101441_RS08360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101441_RS08360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS08365	COG0681	Belongs to the peptidase S26 family
S101441_RS08375	COG0488	(ABC) transporter
S101441_RS08380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101441_RS08390	COG2309	aminopeptidase activity
S101441_RS08400	COG1077	Cell shape determining protein MreB Mrl
S101441_RS08405	COG2002	toxin-antitoxin pair type II binding
S101441_RS08410	COG3852	Histidine kinase
S101441_RS08415	COG2105	PFAM AIG2 family protein
S101441_RS08415	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S101441_RS08420	COG0569	domain protein
S101441_RS08425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101441_RS08430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101441_RS08435	COG5503	Protein of unknown function (DUF1447)
S101441_RS08440	COG0561	phosphatase activity
S101441_RS08445	COG0242	peptide deformylase activity
S101441_RS08455	COG0497	DNA recombination
S101441_RS08460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101441_RS08465	COG0022	dehydrogenase e1 component
S101441_RS08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101441_RS08475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101441_RS08480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS08495	COG1982	Orn Lys Arg decarboxylase major
S101441_RS08500	COG4476	Belongs to the UPF0223 family
S101441_RS08505	COG4493	Belongs to the UPF0637 family
S101441_RS08515	COG0483	inositol monophosphate 1-phosphatase activity
S101441_RS08525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S101441_RS08570	COG1217	gtp-binding protein TYPA
S101441_RS08580	COG4896	Protein conserved in bacteria
S101441_RS08590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S101441_RS08595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101441_RS08600	COG2066	Belongs to the glutaminase family
S101441_RS08605	COG4838	Belongs to the UPF0358 family
S101441_RS08610	COG0772	Belongs to the SEDS family
S101441_RS08615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S101441_RS08625	COG1612	heme a metabolic process
S101441_RS08630	COG0109	protoheme IX farnesyltransferase activity
S101441_RS08635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101441_RS08635	COG2010	Cytochrome c
S101441_RS08640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101441_RS08645	COG1845	cytochrome c oxidase, subunit III
S101441_RS08650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101441_RS08655	COG3336	cytochrome c oxidase
S101441_RS08665	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S101441_RS08670	COG2340	Cysteine-rich secretory protein family
S101441_RS08685	COG3679	Belongs to the UPF0342 family
S101441_RS08690	COG4471	UPF0298 protein
S101441_RS08695	COG0742	ribosomal rna small subunit methyltransferase
S101441_RS08700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101441_RS08705	COG3314	Sporulation integral membrane protein YlbJ
S101441_RS08710	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101441_RS08715	COG3480	Lon protease (S16) C-terminal proteolytic domain
S101441_RS08720	COG1323	Belongs to the UPF0348 family
S101441_RS08730	COG1399	metal-binding, possibly nucleic acid-binding protein
S101441_RS08745	COG0454	-acetyltransferase
S101441_RS08750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101441_RS08755	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S101441_RS08760	COG2001	Belongs to the MraZ family
S101441_RS08765	COG0275	rRNA processing
S101441_RS08770	COG4839	cell division protein FtsL
S101441_RS08775	COG0768	penicillin binding
S101441_RS08780	COG0768	penicillin binding
S101441_RS08785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S101441_RS08790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101441_RS08795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101441_RS08800	COG0772	Belongs to the SEDS family
S101441_RS08805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101441_RS08810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S101441_RS08815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101441_RS08820	COG3879	Bacterial protein of unknown function (DUF881)
S101441_RS08825	COG3879	Bacterial protein of unknown function (DUF881)
S101441_RS08830	COG3856	small basic protein
S101441_RS08835	COG0849	cell division
S101441_RS08840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S101441_RS08845	COG4412	M6 family metalloprotease domain protein
S101441_RS08845	COG1404	Belongs to the peptidase S8 family
S101441_RS08855	COG1191	sigma factor activity
S101441_RS08860	COG1191	sigma factor activity
S101441_RS08865	COG1119	ATPase activity
S101441_RS08870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101441_RS08875	COG1873	PFAM PRC-barrel domain
S101441_RS08880	COG1496	oxidoreductase activity
S101441_RS08885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S101441_RS08890	COG1799	cell septum assembly
S101441_RS08895	COG0762	integral membrane protein
S101441_RS08900	COG2302	S4 RNA-binding domain
S101441_RS08905	COG3599	regulation of cell shape
S101441_RS08910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101441_RS08920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101441_RS08925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101441_RS08930	COG0564	pseudouridine synthase activity
S101441_RS08935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S101441_RS08940	COG2233	PERMEase
S101441_RS08945	COG0540	Belongs to the ATCase OTCase family
S101441_RS08950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101441_RS08955	COG0505	Belongs to the CarA family
S101441_RS08960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101441_RS08965	COG0543	2 iron, 2 sulfur cluster binding
S101441_RS08970	COG0167	dihydroorotate dehydrogenase activity
S101441_RS08975	COG0284	orotidine-5'-phosphate decarboxylase activity
S101441_RS08980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101441_RS08985	COG0175	sulfate reduction
S101441_RS08990	COG0306	phosphate transporter
S101441_RS08995	COG2046	Belongs to the sulfate adenylyltransferase family
S101441_RS09000	COG0529	Catalyzes the synthesis of activated sulfate
S101441_RS09005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101441_RS09010	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S101441_RS09015	COG1648	precorrin-2 dehydrogenase activity
S101441_RS09025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101441_RS09030	COG1561	YicC-like family, N-terminal region
S101441_RS09040	COG0194	GDP metabolic process
S101441_RS09045	COG1758	RNA polymerase activity
S101441_RS09050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101441_RS09055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101441_RS09060	COG0242	peptide deformylase activity
S101441_RS09065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101441_RS09070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101441_RS09070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101441_RS09075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S101441_RS09080	COG0631	protein serine/threonine phosphatase activity
S101441_RS09085	COG0515	serine threonine protein kinase
S101441_RS09085	COG2815	serine threonine protein kinase
S101441_RS09090	COG1162	GTPase activity
S101441_RS09095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101441_RS09100	COG1564	THIamine pyrophosphokinase
S101441_RS09110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101441_RS09115	COG1302	Protein conserved in bacteria
S101441_RS09120	COG1461	Dihydroxyacetone kinase
S101441_RS09125	COG1760	l-serine dehydratase
S101441_RS09130	COG1760	l-serine dehydratase
S101441_RS09135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S101441_RS09140	COG2050	protein possibly involved in aromatic compounds catabolism
S101441_RS09140	COG1349	DNA-binding transcription factor activity
S101441_RS09145	COG0416	fatty acid biosynthetic process
S101441_RS09150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101441_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS09165	COG0571	ribonuclease III activity
S101441_RS09170	COG1196	nuclear chromosome segregation
S101441_RS09175	COG0552	protein localization to endoplasmic reticulum
S101441_RS09185	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S101441_RS09190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S101441_RS09195	COG0228	four-way junction DNA binding
S101441_RS09200	COG1837	Belongs to the UPF0109 family
S101441_RS09210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101441_RS09215	COG0336	Belongs to the RNA methyltransferase TrmD family
S101441_RS09220	COG0335	large ribosomal subunit rRNA binding
S101441_RS09225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101441_RS09230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101441_RS09240	COG2257	FlhB HrpN YscU SpaS Family
S101441_RS09245	COG0045	succinate-CoA ligase (ADP-forming) activity
S101441_RS09250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S101441_RS09255	COG0758	DNA mediated transformation
S101441_RS09260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101441_RS09265	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S101441_RS09270	COG4974	Belongs to the 'phage' integrase family
S101441_RS09275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101441_RS09280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101441_RS09285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101441_RS09290	COG1815	bacterial-type flagellum-dependent cell motility
S101441_RS09295	COG1558	bacterial-type flagellum-dependent cell motility
S101441_RS09300	COG1677	Flagellar hook-basal body complex protein FliE
S101441_RS09305	COG1766	The M ring may be actively involved in energy transduction
S101441_RS09310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101441_RS09315	COG1317	bacterial-type flagellum organization
S101441_RS09320	COG1157	protein secretion by the type III secretion system
S101441_RS09325	COG2882	bacterial-type flagellum organization
S101441_RS09330	COG3334	PFAM MgtE intracellular
S101441_RS09335	COG3144	bacterial-type flagellum assembly
S101441_RS09340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S101441_RS09345	COG4786	Flagellar basal body rod
S101441_RS09350	COG1582	Flagellar protein (FlbD)
S101441_RS09355	COG1580	Controls the rotational direction of flagella during chemotaxis
S101441_RS09360	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101441_RS09365	COG1776	CheC inhibitor of MCP methylation
S101441_RS09365	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101441_RS09370	COG2201	protein-glutamate methylesterase activity
S101441_RS09375	COG3190	flagellar
S101441_RS09380	COG1338	Plays a role in the flagellum-specific transport system
S101441_RS09385	COG1987	bacterial-type flagellum assembly
S101441_RS09390	COG1684	flagellar biosynthetic protein fliR
S101441_RS09395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101441_RS09400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101441_RS09405	COG1419	protein localization to endoplasmic reticulum
S101441_RS09410	COG0455	bacterial-type flagellum organization
S101441_RS09415	COG2201	protein-glutamate methylesterase activity
S101441_RS09420	COG0643	Histidine kinase
S101441_RS09420	COG2198	Histidine kinase
S101441_RS09425	COG0835	chemotaxis
S101441_RS09430	COG1776	CheC inhibitor of MCP methylation
S101441_RS09435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S101441_RS09440	COG1191	sigma factor activity
S101441_RS09450	COG0052	Belongs to the universal ribosomal protein uS2 family
S101441_RS09455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101441_RS09460	COG0528	UMP kinase activity
S101441_RS09465	COG0233	cytoplasmic translational termination
S101441_RS09470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101441_RS09475	COG4589	Belongs to the CDS family
S101441_RS09480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S101441_RS09485	COG0750	zinc metalloprotease
S101441_RS09490	COG0442	prolyl-tRNA aminoacylation
S101441_RS09495	COG2176	DNA-directed DNA polymerase activity
S101441_RS09500	COG0779	Required for maturation of 30S ribosomal subunits
S101441_RS09505	COG0195	Participates in both transcription termination and antitermination
S101441_RS09510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S101441_RS09515	COG1358	cellular component organization or biogenesis
S101441_RS09520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S101441_RS09525	COG1550	Protein conserved in bacteria
S101441_RS09530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101441_RS09535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101441_RS09540	COG0196	riboflavin kinase activity
S101441_RS09545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S101441_RS09550	COG1185	polyribonucleotide nucleotidyltransferase activity
S101441_RS09555	COG0726	polysaccharide deacetylase
S101441_RS09560	COG0612	Peptidase, M16
S101441_RS09565	COG1873	PFAM PRC-barrel domain
S101441_RS09570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101441_RS09575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101441_RS09580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S101441_RS09585	COG0527	aspartate kinase activity
S101441_RS09590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101441_RS09595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101441_RS09600	COG0740	serine-type endopeptidase activity
S101441_RS09610	COG4980	gas vesicle protein
S101441_RS09610	COG1674	ftsk spoiiie
S101441_RS09615	COG2188	Transcriptional regulator
S101441_RS09620	COG2814	Major facilitator Superfamily
S101441_RS09625	COG0612	Peptidase, M16
S101441_RS09630	COG0612	Peptidase, M16
S101441_RS09635	COG0300	oxidoreductase activity
S101441_RS09650	COG1426	Protein conserved in bacteria
S101441_RS09655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101441_RS09660	COG1546	Belongs to the CinA family
S101441_RS09660	COG1058	Belongs to the CinA family
S101441_RS09665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S101441_RS09670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101441_RS09675	COG1418	mRNA catabolic process
S101441_RS09680	COG1692	metallophosphoesterase
S101441_RS09685	COG2359	stage V sporulation protein S
S101441_RS09690	COG1063	alcohol dehydrogenase
S101441_RS09695	COG0156	8-amino-7-oxononanoate synthase activity
S101441_RS09705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101441_RS09710	COG4550	Control of competence regulator ComK, YlbF/YmcA
S101441_RS09720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101441_RS09725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101441_RS09805	COG3328	transposase activity
S101441_RS09825	COG3226	Transcriptional regulator
S101441_RS09835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS09840	COG1404	Belongs to the peptidase S8 family
S101441_RS09850	COG4195	phage-related replication protein
S101441_RS09855	COG1764	response to oxidative stress
S101441_RS09860	COG2076	Multidrug Resistance protein
S101441_RS09865	COG2076	Multidrug Resistance protein
S101441_RS09880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101441_RS09885	COG1923	regulation of RNA biosynthetic process
S101441_RS09900	COG1780	Probably involved in ribonucleotide reductase function
S101441_RS09905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101441_RS09910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101441_RS09915	COG4112	unkown
S101441_RS09920	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS09930	COG0464	growth
S101441_RS09935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101441_RS09940	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S101441_RS09945	COG0789	Transcriptional regulator
S101441_RS09950	COG0174	glutamine synthetase
S101441_RS09970	COG5444	nuclease activity
S101441_RS10000	COG4282	regulation of fungal-type cell wall biogenesis
S101441_RS10010	COG3328	transposase activity
S101441_RS10020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS10035	COG3655	Transcriptional regulator
S101441_RS10060	COG0135	phosphoribosylanthranilate isomerase activity
S101441_RS10065	COG2211	Major facilitator Superfamily
S101441_RS10070	COG3507	Belongs to the glycosyl hydrolase 43 family
S101441_RS10075	COG1940	carbohydrate kinase activity
S101441_RS10080	COG2115	Belongs to the xylose isomerase family
S101441_RS10085	COG1070	Carbohydrate kinase
S101441_RS10095	COG3328	transposase activity
S101441_RS10100	COG1525	nuclease
S101441_RS10105	COG2814	Major facilitator Superfamily
S101441_RS10110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101441_RS10125	COG0756	dUTP diphosphatase activity
S101441_RS10170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101441_RS10180	COG3832	glyoxalase III activity
S101441_RS10225	COG4195	phage-related replication protein
S101441_RS10235	COG0346	lactoylglutathione lyase activity
S101441_RS10245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101441_RS10250	COG1388	LysM domain
S101441_RS10255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101441_RS10260	COG4224	UPF0291 protein
S101441_RS10265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S101441_RS10275	COG3763	UPF0154 protein
S101441_RS10285	COG0785	Cytochrome C biogenesis protein
S101441_RS10290	COG2201	protein-glutamate methylesterase activity
S101441_RS10295	COG4846	Membrane protein involved in cytochrome C biogenesis
S101441_RS10310	COG0071	Belongs to the small heat shock protein (HSP20) family
S101441_RS10325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S101441_RS10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS10350	COG0824	Thioesterase
S101441_RS10360	COG4841	protein insertion into membrane
S101441_RS10365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101441_RS10370	COG1832	CoA-binding protein
S101441_RS10375	COG0187	DNA topoisomerase II activity
S101441_RS10380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101441_RS10390	COG1115	amino acid carrier protein
S101441_RS10395	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S101441_RS10415	COG2246	polysaccharide biosynthetic process
S101441_RS10420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101441_RS10425	COG0586	Pfam SNARE associated Golgi protein
S101441_RS10430	COG2404	hydrolase activity, acting on ester bonds
S101441_RS10435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101441_RS10440	COG1024	Enoyl-CoA hydratase
S101441_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101441_RS10450	COG0511	ligase activity, forming carbon-carbon bonds
S101441_RS10455	COG0439	Biotin carboxylase
S101441_RS10460	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS10465	COG1960	acyl-CoA dehydrogenase activity
S101441_RS10475	COG1649	PFAM Uncharacterised BCR, COG1649
S101441_RS10490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS10495	COG2027	D-alanyl-D-alanine carboxypeptidase
S101441_RS10500	COG2017	converts alpha-aldose to the beta-anomer
S101441_RS10505	COG0534	Mate efflux family protein
S101441_RS10520	COG0582	viral genome integration into host DNA
S101441_RS10525	COG0166	Belongs to the GPI family
S101441_RS10530	COG0405	Gamma-glutamyltransferase
S101441_RS10535	COG0583	DNA-binding transcription factor activity
S101441_RS10540	COG0604	alcohol dehydrogenase
S101441_RS10545	COG0493	'glutamate synthase
S101441_RS10550	COG0069	glutamate synthase activity
S101441_RS10550	COG0070	glutamate synthase
S101441_RS10550	COG0067	glutamate synthase
S101441_RS10555	COG0583	DNA-binding transcription factor activity
S101441_RS10560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101441_RS10565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101441_RS10570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101441_RS10575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101441_RS10585	COG0300	oxidoreductase activity
S101441_RS10590	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101441_RS10600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS10615	COG1131	(ABC) transporter
S101441_RS10625	COG2814	Major facilitator Superfamily
S101441_RS10635	COG2323	membrane
S101441_RS10640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101441_RS10650	COG2323	membrane
S101441_RS10665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101441_RS10685	COG3546	catalase activity
S101441_RS10705	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS10725	COG5278	phosphoserine phosphatase activity
S101441_RS10725	COG0840	transmembrane signaling receptor activity
S101441_RS10730	COG2368	4-hydroxyphenylacetate
S101441_RS10735	COG4305	rare lipoprotein A
S101441_RS10740	COG3619	membrane
S101441_RS10760	COG2140	Oxalate decarboxylase
S101441_RS10785	COG2720	vancomycin resistance protein
S101441_RS10800	COG3739	integral membrane protein
S101441_RS10805	COG0583	DNA-binding transcription factor activity
S101441_RS10810	COG0697	spore germination
S101441_RS10820	COG0693	protein deglycase activity
S101441_RS10825	COG2367	Beta-lactamase
S101441_RS10830	COG4282	regulation of fungal-type cell wall biogenesis
S101441_RS10850	COG3848	Pyruvate phosphate dikinase
S101441_RS10850	COG0574	Belongs to the PEP-utilizing enzyme family
S101441_RS10855	COG0726	polysaccharide deacetylase
S101441_RS10865	COG2314	TM2 domain
S101441_RS10870	COG1396	sequence-specific DNA binding
S101441_RS10955	COG3655	Transcriptional regulator
S101441_RS11005	COG0457	Tetratricopeptide repeat
S101441_RS11010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS11020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101441_RS11025	COG2226	methyltransferase
S101441_RS11030	COG2211	Major facilitator Superfamily
S101441_RS11035	COG3328	transposase activity
S101441_RS11060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101441_RS11080	COG5444	nuclease activity
S101441_RS11085	COG4282	regulation of fungal-type cell wall biogenesis
S101441_RS11090	COG1231	oxidoreductase activity
S101441_RS11095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101441_RS11100	COG2207	Transcriptional regulator
S101441_RS11100	COG0662	Cupin 2, conserved barrel domain protein
S101441_RS11105	COG0456	acetyltransferase
S101441_RS11110	COG1309	transcriptional regulator
S101441_RS11115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS11120	COG3708	Transcriptional regulator
S101441_RS11125	COG2378	regulation of single-species biofilm formation
S101441_RS11135	COG0640	Transcriptional regulator
S101441_RS11140	COG0741	lytic transglycosylase activity
S101441_RS11155	COG2322	membrane
S101441_RS11170	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101441_RS11175	COG3239	Fatty acid desaturase
S101441_RS11180	COG4585	Histidine kinase
S101441_RS11185	COG2197	response regulator
S101441_RS11190	COG1388	LysM domain
S101441_RS11190	COG3584	3D domain protein
S101441_RS11195	COG0514	ATP-dependent DNA helicase (RecQ)
S101441_RS11210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101441_RS11215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101441_RS11230	COG0071	Belongs to the small heat shock protein (HSP20) family
S101441_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS11260	COG1657	PFAM Prenyltransferase squalene oxidase
S101441_RS11265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101441_RS11270	COG0733	neurotransmitter:sodium symporter activity
S101441_RS11275	COG0385	Bile acid
S101441_RS11280	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101441_RS11285	COG0567	Dehydrogenase, E1 component
S101441_RS11290	COG4548	von Willebrand factor, type A
S101441_RS11295	COG0714	Associated with various cellular activities
S101441_RS11300	COG2032	superoxide dismutase activity
S101441_RS11305	COG1388	LysM domain
S101441_RS11305	COG0791	NLP P60 protein
S101441_RS11310	COG1819	glycosyl
S101441_RS11315	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101441_RS11320	COG0534	Mate efflux family protein
S101441_RS11325	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS11330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101441_RS11335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101441_RS11345	COG2962	Rard protein
S101441_RS11365	COG2610	gluconate transmembrane transporter activity
S101441_RS11370	COG1942	4-Oxalocrotonate Tautomerase
S101441_RS11375	COG1733	regulation of RNA biosynthetic process
S101441_RS11380	COG0778	Nitroreductase
S101441_RS11385	COG0400	carboxylic ester hydrolase activity
S101441_RS11390	COG0346	lactoylglutathione lyase activity
S101441_RS11400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101441_RS11405	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS11405	COG0793	Belongs to the peptidase S41A family
S101441_RS11410	COG2226	methyltransferase
S101441_RS11420	COG1876	peptidase activity
S101441_RS11425	COG0813	purine-nucleoside phosphorylase activity
S101441_RS11440	COG0671	phosphoesterase, PA-phosphatase related
S101441_RS11465	COG4479	Belongs to the UPF0346 family
S101441_RS11475	COG1509	lysine 2,3-aminomutase activity
S101441_RS11480	COG0456	acetyltransferase
S101441_RS11485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101441_RS11495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101441_RS11500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101441_RS11510	COG0456	acetyltransferase
S101441_RS11515	COG0463	Glycosyl transferase, family 2
S101441_RS11530	COG4641	Protein conserved in bacteria
S101441_RS11535	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S101441_RS11540	COG1086	Polysaccharide biosynthesis protein
S101441_RS11545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101441_RS11550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101441_RS11555	COG1846	Transcriptional regulator
S101441_RS11560	COG0534	Mate efflux family protein
S101441_RS11570	COG4698	Protein conserved in bacteria
S101441_RS11575	COG2755	lipolytic protein G-D-S-L family
S101441_RS11580	COG1999	signal sequence binding
S101441_RS11590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S101441_RS11595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101441_RS11600	COG1272	protein, Hemolysin III
S101441_RS11605	COG0204	Acyl-transferase
S101441_RS11610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101441_RS11615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101441_RS11625	COG2521	methyltransferase
S101441_RS11625	COG2136	Putative SAM-dependent methyltransferase
S101441_RS11635	COG0129	dihydroxy-acid dehydratase activity
S101441_RS11640	COG1413	lyase activity
S101441_RS11645	COG1418	mRNA catabolic process
S101441_RS11650	COG0386	Belongs to the glutathione peroxidase family
S101441_RS11655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S101441_RS11660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101441_RS11665	COG1278	Cold shock
S101441_RS11685	COG0328	RNA-DNA hybrid ribonuclease activity
S101441_RS11690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S101441_RS11695	COG0328	RNA-DNA hybrid ribonuclease activity
S101441_RS11705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101441_RS11720	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101441_RS11725	COG1755	Isoprenylcysteine carboxyl methyltransferase
S101441_RS11735	COG2233	PERMEase
S101441_RS11740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101441_RS11745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S101441_RS11755	COG0800	Aldolase
S101441_RS11760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101441_RS11765	COG1609	Transcriptional regulator
S101441_RS11770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101441_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS11780	COG1199	ATP-dependent helicase activity
S101441_RS11795	COG0116	Belongs to the methyltransferase superfamily
S101441_RS11810	COG4474	Belongs to the UPF0398 family
S101441_RS11820	COG3359	exonuclease
S101441_RS11825	COG1205	dead DEAH box helicase
S101441_RS11825	COG1111	helicase
S101441_RS11830	COG2190	(PTS) system
S101441_RS11835	COG0071	Belongs to the small heat shock protein (HSP20) family
S101441_RS11870	COG3331	DNA recombination
S101441_RS11875	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101441_RS11875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101441_RS11885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101441_RS11890	COG3935	DnaD domain protein
S101441_RS11895	COG0017	Asparaginyl-tRNA synthetase
S101441_RS11900	COG0436	Aminotransferase
S101441_RS11905	COG5353	protein conserved in bacteria
S101441_RS11915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101441_RS11915	COG1199	ATP-dependent helicase activity
S101441_RS11920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S101441_RS11925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S101441_RS11930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S101441_RS11935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S101441_RS11935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S101441_RS11940	COG0617	tRNA 3'-terminal CCA addition
S101441_RS11945	COG0438	transferase activity, transferring glycosyl groups
S101441_RS11950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101441_RS11955	COG1803	Methylglyoxal synthase
S101441_RS11960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S101441_RS11965	COG1694	Mazg nucleotide pyrophosphohydrolase
S101441_RS11970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS11980	COG4347	Protein of unknown function (DUF1405)
S101441_RS11985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101441_RS11985	COG2010	Cytochrome c
S101441_RS11990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101441_RS11995	COG0723	plastoquinol--plastocyanin reductase activity
S101441_RS12005	COG5582	Belongs to the UPF0302 family
S101441_RS12010	COG0457	Tetratricopeptide repeat
S101441_RS12015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S101441_RS12020	COG0287	Prephenate dehydrogenase
S101441_RS12035	COG0133	tryptophan synthase activity
S101441_RS12040	COG0135	phosphoribosylanthranilate isomerase activity
S101441_RS12050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101441_RS12055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101441_RS12060	COG4401	Chorismate mutase type I
S101441_RS12065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S101441_RS12070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S101441_RS12075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S101441_RS12080	COG0105	UTP biosynthetic process
S101441_RS12085	COG0142	geranyltranstransferase activity
S101441_RS12090	COG2226	methyltransferase
S101441_RS12095	COG0142	geranyltranstransferase activity
S101441_RS12105	COG0302	gtp cyclohydrolase
S101441_RS12120	COG0776	regulation of translation
S101441_RS12125	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101441_RS12140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101441_RS12145	COG1160	GTP binding
S101441_RS12175	COG1304	FMN binding
S101441_RS12180	COG0539	negative regulation of cytoplasmic translation
S101441_RS12185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101441_RS12195	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S101441_RS12200	COG2959	enzyme of heme biosynthesis
S101441_RS12205	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS12205	COG3773	Cell wall hydrolase
S101441_RS12210	COG2339	peptidase activity
S101441_RS12215	COG0492	ferredoxin-NADP+ reductase activity
S101441_RS12220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101441_RS12225	COG4862	establishment of competence for transformation
S101441_RS12230	COG1408	metallophosphoesterase
S101441_RS12240	COG1388	LysM domain
S101441_RS12245	COG1266	CAAX protease self-immunity
S101441_RS12250	COG0514	ATP-dependent DNA helicase (RecQ)
S101441_RS12255	COG4955	Helix-turn-helix domain
S101441_RS12260	COG1141	Ferredoxin
S101441_RS12265	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S101441_RS12270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101441_RS12275	COG0710	3-dehydroquinate dehydratase activity
S101441_RS12285	COG1595	DNA-templated transcription, initiation
S101441_RS12290	COG5002	protein histidine kinase activity
S101441_RS12295	COG0745	RESPONSE REGULATOR receiver
S101441_RS12300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101441_RS12305	COG1333	cytochrome c biogenesis protein
S101441_RS12310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS12315	COG1187	pseudouridine synthase activity
S101441_RS12320	COG0700	Nucleoside recognition
S101441_RS12325	COG2715	membrane protein required for spore maturation
S101441_RS12330	COG1686	Belongs to the peptidase S11 family
S101441_RS12340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101441_RS12345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101441_RS12350	COG1547	Domain of unknown function (DUF309)
S101441_RS12355	COG0456	acetyltransferase
S101441_RS12360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S101441_RS12365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101441_RS12365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101441_RS12370	COG0307	riboflavin synthase, alpha
S101441_RS12375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101441_RS12375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101441_RS12385	COG0681	Belongs to the peptidase S26 family
S101441_RS12395	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S101441_RS12405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101441_RS12410	COG0741	lytic transglycosylase activity
S101441_RS12410	COG0739	heme binding
S101441_RS12410	COG1196	nuclear chromosome segregation
S101441_RS12445	COG3328	transposase activity
S101441_RS12495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101441_RS12500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101441_RS12510	COG4086	secreted protein
S101441_RS12515	COG0019	diaminopimelate decarboxylase activity
S101441_RS12520	COG0697	spore germination
S101441_RS12535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101441_RS12555	COG1191	sigma factor activity
S101441_RS12560	COG2172	sigma factor antagonist activity
S101441_RS12565	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS12570	COG1686	Belongs to the peptidase S11 family
S101441_RS12575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S101441_RS12580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101441_RS12585	COG4974	Belongs to the 'phage' integrase family
S101441_RS12595	COG0735	belongs to the Fur family
S101441_RS12600	COG1300	Membrane
S101441_RS12610	COG0281	malic enzyme
S101441_RS12615	COG1757	Na H antiporter
S101441_RS12620	COG1027	Aspartate ammonia-lyase
S101441_RS12625	COG0252	asparaginase activity
S101441_RS12630	COG1396	sequence-specific DNA binding
S101441_RS12635	COG1379	DNA repair
S101441_RS12640	COG0494	nUDIX hydrolase
S101441_RS12650	COG0667	Aldo Keto reductase
S101441_RS12660	COG1073	alpha beta
S101441_RS12670	COG4918	Iron-sulphur cluster biosynthesis
S101441_RS12675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S101441_RS12675	COG0456	acetyltransferase
S101441_RS12680	COG2329	Antibiotic biosynthesis monooxygenase
S101441_RS12685	COG0456	acetyltransferase
S101441_RS12695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101441_RS12705	COG2211	Major facilitator Superfamily
S101441_RS12715	COG0346	lactoylglutathione lyase activity
S101441_RS12720	COG1072	(Pantothenic acid kinase))
S101441_RS12725	COG3048	D-serine ammonia-lyase activity
S101441_RS12730	COG0300	oxidoreductase activity
S101441_RS12735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS12740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101441_RS12755	COG4187	Peptidase family M20/M25/M40
S101441_RS12760	COG1902	pentaerythritol trinitrate reductase activity
S101441_RS12765	COG0596	Alpha beta hydrolase
S101441_RS12775	COG1234	tRNA 3'-trailer cleavage
S101441_RS12780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S101441_RS12785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101441_RS12790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101441_RS12800	COG0706	membrane insertase activity
S101441_RS12805	COG3361	conserved protein (COG2071)
S101441_RS12810	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101441_RS12815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101441_RS12820	COG0346	lactoylglutathione lyase activity
S101441_RS12825	COG1376	ErfK ybiS ycfS ynhG family protein
S101441_RS12830	COG4129	membrane
S101441_RS12835	COG1126	abc transporter atp-binding protein
S101441_RS12840	COG0765	amino acid transport
S101441_RS12845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101441_RS12855	COG1597	lipid kinase activity
S101441_RS12860	COG2814	Major facilitator Superfamily
S101441_RS12865	COG4978	Transcriptional regulator
S101441_RS12865	COG0789	Transcriptional regulator
S101441_RS12870	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101441_RS12875	COG0022	dehydrogenase e1 component
S101441_RS12880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101441_RS12885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101441_RS12890	COG3426	butyrate kinase activity
S101441_RS12895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101441_RS12900	COG0280	phosphate acetyltransferase
S101441_RS12905	COG3829	transcription factor binding
S101441_RS12905	COG3290	protein histidine kinase activity
S101441_RS12915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S101441_RS12920	COG2079	MmgE PrpD family protein
S101441_RS12925	COG0372	Belongs to the citrate synthase family
S101441_RS12930	COG1960	acyl-CoA dehydrogenase activity
S101441_RS12935	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101441_RS12940	COG0183	Belongs to the thiolase family
S101441_RS12945	COG0584	glycerophosphoryl diester phosphodiesterase
S101441_RS12950	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS12960	COG1902	pentaerythritol trinitrate reductase activity
S101441_RS12965	COG0745	RESPONSE REGULATOR receiver
S101441_RS12975	COG0750	zinc metalloprotease
S101441_RS12980	COG0497	DNA recombination
S101441_RS12985	COG1438	arginine binding
S101441_RS12990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101441_RS12995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101441_RS13000	COG0142	geranyltranstransferase activity
S101441_RS13005	COG1722	exodeoxyribonuclease VII activity
S101441_RS13010	COG1570	exodeoxyribonuclease VII activity
S101441_RS13015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101441_RS13020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101441_RS13025	COG1302	Protein conserved in bacteria
S101441_RS13030	COG0439	Biotin carboxylase
S101441_RS13035	COG0511	ligase activity, forming carbon-carbon bonds
S101441_RS13075	COG3854	ATPases associated with a variety of cellular activities
S101441_RS13085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101441_RS13090	COG0006	proline dipeptidase activity
S101441_RS13095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S101441_RS13105	COG3872	metal-dependent enzyme
S101441_RS13115	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101441_RS13120	COG1321	iron dependent repressor
S101441_RS13125	COG0095	Lipoate-protein ligase
S101441_RS13130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101441_RS13135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101441_RS13140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101441_RS13145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S101441_RS13150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101441_RS13165	COG1396	sequence-specific DNA binding
S101441_RS13175	COG0681	Belongs to the peptidase S26 family
S101441_RS13200	COG4940	Competence protein ComGF
S101441_RS13210	COG4970	Tfp pilus assembly protein FimT
S101441_RS13215	COG4537	Required for transformation and DNA binding
S101441_RS13220	COG1459	type II secretion system
S101441_RS13225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S101441_RS13230	COG0517	IMP dehydrogenase activity
S101441_RS13235	COG0598	Magnesium transport protein CorA
S101441_RS13240	COG1253	flavin adenine dinucleotide binding
S101441_RS13245	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS13255	COG1393	Belongs to the ArsC family
S101441_RS13270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS13280	COG0011	TIGRFAM Protein of
S101441_RS13290	COG2866	Carboxypeptidase
S101441_RS13295	COG1368	sulfuric ester hydrolase activity
S101441_RS13300	COG1940	carbohydrate kinase activity
S101441_RS13305	COG4483	Protein conserved in bacteria
S101441_RS13310	COG0457	Tetratricopeptide repeat
S101441_RS13310	COG0705	Rhomboid family
S101441_RS13320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101441_RS13330	COG0438	transferase activity, transferring glycosyl groups
S101441_RS13345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101441_RS13350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101441_RS13355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101441_RS13360	COG0581	inorganic phosphate transmembrane transporter activity
S101441_RS13365	COG0573	inorganic phosphate transmembrane transporter activity
S101441_RS13370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S101441_RS13375	COG0768	penicillin binding
S101441_RS13380	COG0477	Major facilitator Superfamily
S101441_RS13385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101441_RS13390	COG2839	Protein conserved in bacteria
S101441_RS13395	COG5521	maltodextrose utilization protein MalA
S101441_RS13400	COG1388	LysM domain
S101441_RS13405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S101441_RS13410	COG4709	membrane
S101441_RS13415	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S101441_RS13420	COG0735	belongs to the Fur family
S101441_RS13425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS13435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S101441_RS13440	COG0513	Belongs to the DEAD box helicase family
S101441_RS13450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S101441_RS13460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S101441_RS13465	COG2384	SAM-dependent methyltransferase
S101441_RS13470	COG2010	Cytochrome c
S101441_RS13480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101441_RS13485	COG0358	DNA primase activity
S101441_RS13490	COG1671	Belongs to the UPF0178 family
S101441_RS13495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101441_RS13500	COG0517	IMP dehydrogenase activity
S101441_RS13505	COG0751	glycine-tRNA ligase activity
S101441_RS13510	COG0752	glycyl-tRNA synthetase alpha subunit
S101441_RS13515	COG1381	Involved in DNA repair and RecF pathway recombination
S101441_RS13525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101441_RS13530	COG0295	cytidine deaminase activity
S101441_RS13535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S101441_RS13540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S101441_RS13545	COG1480	7TM receptor with intracellular HD hydrolase
S101441_RS13550	COG1702	phosphate starvation-inducible protein PhoH
S101441_RS13555	COG0561	phosphatase activity
S101441_RS13570	COG4864	UPF0365 protein
S101441_RS13575	COG1030	water channel activity
S101441_RS13580	COG1610	YqeY-like protein
S101441_RS13590	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101441_RS13595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101441_RS13600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S101441_RS13605	COG2264	protein methyltransferase activity
S101441_RS13610	COG0484	heat shock protein binding
S101441_RS13615	COG0443	Heat shock 70 kDa protein
S101441_RS13620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101441_RS13625	COG1420	regulation of RNA biosynthetic process
S101441_RS13630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101441_RS13635	COG0481	GTPase activity
S101441_RS13645	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS13650	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S101441_RS13655	COG0268	Binds directly to 16S ribosomal RNA
S101441_RS13660	COG1466	dna polymerase III delta subunit
S101441_RS13670	COG2333	competence protein COMEC
S101441_RS13670	COG0658	competence protein
S101441_RS13675	COG2131	deaminase
S101441_RS13680	COG1596	polysaccharide export
S101441_RS13680	COG1555	photosystem II stabilization
S101441_RS13685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101441_RS13690	COG2226	methyltransferase
S101441_RS13695	COG0799	negative regulation of ribosome biogenesis
S101441_RS13700	COG1713	HD superfamily hydrolase involved in NAD metabolism
S101441_RS13705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101441_RS13710	COG1534	Rna-binding protein
S101441_RS13715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101441_RS13720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101441_RS13725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S101441_RS13735	COG2755	lipolytic protein G-D-S-L family
S101441_RS13740	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS13740	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS13745	COG0398	Pfam SNARE associated Golgi protein
S101441_RS13750	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S101441_RS13760	COG3209	COG3209 Rhs family protein
S101441_RS13775	COG0114	fumarate hydratase activity
S101441_RS13780	COG0583	DNA-binding transcription factor activity
S101441_RS13795	COG0457	Tetratricopeptide repeat
S101441_RS13895	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S101441_RS13900	COG1484	DNA-dependent DNA replication
S101441_RS13915	COG0789	Transcriptional regulator
S101441_RS13915	COG4978	Transcriptional regulator
S101441_RS13920	COG2814	Major facilitator Superfamily
S101441_RS13925	COG0456	acetyltransferase
S101441_RS13930	COG3328	transposase activity
S101441_RS13935	COG1253	flavin adenine dinucleotide binding
S101441_RS13945	COG0697	spore germination
S101441_RS13950	COG0583	DNA-binding transcription factor activity
S101441_RS13955	COG2072	flavoprotein involved in K transport
S101441_RS13960	COG1230	cation diffusion facilitator family transporter
S101441_RS13970	COG1942	4-Oxalocrotonate Tautomerase
S101441_RS13975	COG1114	Component of the transport system for branched-chain amino acids
S101441_RS13980	COG1687	branched-chain amino acid
S101441_RS13985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S101441_RS13990	COG1522	sequence-specific DNA binding
S101441_RS13995	COG2732	(Barnase) inhibitor
S101441_RS14000	COG2124	cytochrome p450
S101441_RS14005	COG1335	isochorismatase
S101441_RS14015	COG2318	DinB family
S101441_RS14025	COG2070	2-Nitropropane dioxygenase
S101441_RS14040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101441_RS14055	COG3443	Belongs to the bacterial solute-binding protein 9 family
S101441_RS14060	COG1595	DNA-templated transcription, initiation
S101441_RS14065	COG0667	Aldo Keto reductase
S101441_RS14070	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS14075	COG5566	PFAM Mor transcription activator
S101441_RS14080	COG0596	Alpha beta hydrolase
S101441_RS14085	COG4991	sh3 domain protein
S101441_RS14090	COG4991	sh3 domain protein
S101441_RS14095	COG0346	lactoylglutathione lyase activity
S101441_RS14105	COG5577	PFAM Coat F domain
S101441_RS14110	COG1063	alcohol dehydrogenase
S101441_RS14120	COG5577	PFAM Coat F domain
S101441_RS14125	COG0789	Transcriptional regulator
S101441_RS14135	COG1064	alcohol dehydrogenase
S101441_RS14140	COG0693	protein deglycase activity
S101441_RS14145	COG1621	beta-fructofuranosidase activity
S101441_RS14150	COG3716	PTS system mannose fructose sorbose family IID component
S101441_RS14155	COG3715	PTS system
S101441_RS14160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS14165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS14170	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S101441_RS14170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101441_RS14175	COG1113	amino acid transport
S101441_RS14180	COG1280	lysine exporter protein (LysE YggA)
S101441_RS14185	COG1378	Sugar-specific transcriptional regulator TrmB
S101441_RS14190	COG1595	DNA-templated transcription, initiation
S101441_RS14210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101441_RS14210	COG2124	cytochrome p450
S101441_RS14215	COG1309	transcriptional regulator
S101441_RS14220	COG2226	methyltransferase
S101441_RS14230	COG2116	formate transmembrane transporter activity
S101441_RS14235	COG5609	conserved protein (DUF2294)
S101441_RS14240	COG3383	formate dehydrogenase (NAD+) activity
S101441_RS14245	COG2427	Protein of unknown function (DUF1641)
S101441_RS14255	COG0626	cystathionine gamma-synthase activity
S101441_RS14260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101441_RS14265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S101441_RS14270	COG2226	methyltransferase
S101441_RS14285	COG0768	penicillin binding
S101441_RS14290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101441_RS14295	COG0572	uridine kinase
S101441_RS14300	COG0826	peptidase U32
S101441_RS14305	COG0826	peptidase U32
S101441_RS14310	COG4122	O-methyltransferase activity
S101441_RS14315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101441_RS14320	COG3906	Belongs to the UPF0473 family
S101441_RS14325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101441_RS14330	COG4472	Bacterial protein of unknown function (DUF965)
S101441_RS14335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101441_RS14340	COG0628	permease
S101441_RS14345	COG1126	abc transporter atp-binding protein
S101441_RS14350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101441_RS14355	COG0765	amino acid transport
S101441_RS14360	COG0765	amino acid transport
S101441_RS14380	COG3881	PFAM PRC-barrel domain
S101441_RS14385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101441_RS14390	COG0457	Tetratricopeptide repeat
S101441_RS14395	COG0482	sulfurtransferase activity
S101441_RS14400	COG1104	cysteine desulfurase activity
S101441_RS14405	COG1959	2 iron, 2 sulfur cluster binding
S101441_RS14410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101441_RS14415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S101441_RS14425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101441_RS14430	COG0124	histidyl-tRNA synthetase
S101441_RS14440	COG4991	sh3 domain protein
S101441_RS14440	COG3103	Sh3 type 3 domain protein
S101441_RS14440	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101441_RS14445	COG1490	D-aminoacyl-tRNA deacylase activity
S101441_RS14450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101441_RS14455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101441_RS14460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S101441_RS14460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101441_RS14465	COG5416	Lipopolysaccharide assembly protein A domain
S101441_RS14470	COG0490	domain, Protein
S101441_RS14475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101441_RS14475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101441_RS14485	COG2244	polysaccharide biosynthetic process
S101441_RS14490	COG2323	membrane
S101441_RS14500	COG1862	Preprotein translocase
S101441_RS14505	COG0343	queuine tRNA-ribosyltransferase activity
S101441_RS14510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101441_RS14520	COG2255	four-way junction helicase activity
S101441_RS14525	COG0632	four-way junction helicase activity
S101441_RS14535	COG2814	Major facilitator Superfamily
S101441_RS14540	COG0673	inositol 2-dehydrogenase activity
S101441_RS14545	COG2112	serine threonine protein kinase
S101441_RS14560	COG1115	amino acid carrier protein
S101441_RS14565	COG0217	transcriptional regulatory protein
S101441_RS14575	COG1388	LysM domain
S101441_RS14580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S101441_RS14585	COG0157	Belongs to the NadC ModD family
S101441_RS14590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S101441_RS14595	COG1104	cysteine desulfurase activity
S101441_RS14600	COG1827	regulation of RNA biosynthetic process
S101441_RS14605	COG0077	Prephenate dehydratase
S101441_RS14610	COG4492	Belongs to the UPF0735 family
S101441_RS14615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101441_RS14620	COG3290	protein histidine kinase activity
S101441_RS14625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101441_RS14630	COG2868	ribosomal protein
S101441_RS14635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101441_RS14640	COG1994	Peptidase M50
S101441_RS14645	COG0739	heme binding
S101441_RS14650	COG2894	cell division
S101441_RS14655	COG0850	regulation of cytokinetic process
S101441_RS14660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S101441_RS14670	COG1077	Cell shape determining protein MreB Mrl
S101441_RS14675	COG2003	Belongs to the UPF0758 family
S101441_RS14680	COG0424	maF-like protein
S101441_RS14690	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S101441_RS14695	COG0285	dihydrofolate synthase activity
S101441_RS14700	COG0525	valine-tRNA ligase activity
S101441_RS14710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101441_RS14715	COG1388	LysM domain
S101441_RS14720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101441_RS14725	COG0113	porphobilinogen synthase activity
S101441_RS14730	COG1587	Uroporphyrinogen-III synthase
S101441_RS14735	COG0181	hydroxymethylbilane synthase activity
S101441_RS14740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101441_RS14745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S101441_RS14755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101441_RS14760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S101441_RS14765	COG0470	DNA polymerase III
S101441_RS14765	COG1067	ATP-dependent peptidase activity
S101441_RS14770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S101441_RS14775	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101441_RS14780	COG0457	Tetratricopeptide repeat
S101441_RS14780	COG1477	protein flavinylation
S101441_RS14785	COG0066	3-isopropylmalate dehydratase activity
S101441_RS14790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S101441_RS14795	COG0473	3-isopropylmalate dehydrogenase activity
S101441_RS14800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101441_RS14805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S101441_RS14810	COG0440	acetolactate synthase activity
S101441_RS14815	COG0028	Belongs to the TPP enzyme family
S101441_RS14830	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S101441_RS14860	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
S101441_RS14885	COG0622	Phosphoesterase
S101441_RS14890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101441_RS14895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S101441_RS14900	COG5401	PFAM Sporulation and spore germination
S101441_RS14905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101441_RS14910	COG1846	Transcriptional regulator
S101441_RS14915	COG2197	response regulator
S101441_RS14920	COG0824	Thioesterase
S101441_RS14925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101441_RS14930	COG1053	succinate dehydrogenase
S101441_RS14935	COG2009	succinate dehydrogenase
S101441_RS14940	COG1719	4-vinyl reductase, 4VR
S101441_RS14945	COG0527	aspartate kinase activity
S101441_RS14955	COG0322	excinuclease ABC activity
S101441_RS14960	COG3118	belongs to the thioredoxin family
S101441_RS14965	COG3534	alpha-L-arabinofuranosidase
S101441_RS14970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S101441_RS14975	COG2086	electron transfer activity
S101441_RS14980	COG1024	Enoyl-CoA hydratase
S101441_RS14985	COG1309	transcriptional regulator
S101441_RS14990	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS14995	COG3766	membrane
S101441_RS15005	COG1796	DNA polymerase
S101441_RS15005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101441_RS15010	COG1286	toxin biosynthetic process
S101441_RS15015	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S101441_RS15020	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101441_RS15025	COG0072	phenylalanine-tRNA ligase activity
S101441_RS15025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101441_RS15030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101441_RS15040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101441_RS15050	COG3835	regulator
S101441_RS15055	COG0277	FAD linked oxidase domain protein
S101441_RS15060	COG0247	lactate metabolic process
S101441_RS15065	COG0346	lactoylglutathione lyase activity
S101441_RS15070	COG1966	Carbon starvation protein
S101441_RS15075	COG3534	alpha-L-arabinofuranosidase
S101441_RS15080	COG0395	ABC-type sugar transport system, permease component
S101441_RS15085	COG1175	transmembrane transport
S101441_RS15090	COG1653	transport
S101441_RS15095	COG0371	Dehydrogenase
S101441_RS15105	COG0235	Class ii aldolase
S101441_RS15110	COG1069	ribulokinase activity
S101441_RS15115	COG2160	L-arabinose isomerase activity
S101441_RS15120	COG3507	Belongs to the glycosyl hydrolase 43 family
S101441_RS15125	COG1363	Peptidase, m42
S101441_RS15135	COG3326	Membrane
S101441_RS15140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101441_RS15145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101441_RS15150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101441_RS15160	COG1346	cytolysis
S101441_RS15165	COG1380	Effector of murein hydrolase LrgA
S101441_RS15170	COG3279	Response regulator of the LytR AlgR family
S101441_RS15175	COG3275	phosphorelay sensor kinase activity
S101441_RS15180	COG1011	Hydrolase
S101441_RS15185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101441_RS15195	COG0398	Pfam SNARE associated Golgi protein
S101441_RS15200	COG1484	DNA-dependent DNA replication
S101441_RS15205	COG3611	Membrane attachment protein
S101441_RS15210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101441_RS15215	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S101441_RS15220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101441_RS15225	COG1733	regulation of RNA biosynthetic process
S101441_RS15230	COG2814	Major facilitator Superfamily
S101441_RS15235	COG0656	L-ascorbic acid biosynthetic process
S101441_RS15245	COG0237	dephospho-CoA kinase activity
S101441_RS15250	COG1971	Probably functions as a manganese efflux pump
S101441_RS15255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101441_RS15260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101441_RS15260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101441_RS15265	COG5002	protein histidine kinase activity
S101441_RS15270	COG0745	RESPONSE REGULATOR receiver
S101441_RS15275	COG0039	L-malate dehydrogenase activity
S101441_RS15280	COG0538	isocitrate dehydrogenase activity
S101441_RS15285	COG0372	Belongs to the citrate synthase family
S101441_RS15295	COG2707	UPF0756 membrane protein
S101441_RS15300	COG0628	permease
S101441_RS15305	COG3030	protein affecting phage T7 exclusion by the F plasmid
S101441_RS15310	COG0469	pyruvate kinase activity
S101441_RS15315	COG0205	6-phosphofructokinase activity
S101441_RS15320	COG0825	malonyl-CoA metabolic process
S101441_RS15325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101441_RS15330	COG0281	malic enzyme
S101441_RS15335	COG0587	DNA-directed DNA polymerase activity
S101441_RS15355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S101441_RS15365	COG4109	DRTGG domain
S101441_RS15370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101441_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS15385	COG0165	Argininosuccinate lyase
S101441_RS15390	COG0137	argininosuccinate synthase activity
S101441_RS15395	COG0521	Mo-molybdopterin cofactor biosynthetic process
S101441_RS15400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S101441_RS15410	COG0827	DNA restriction-modification system
S101441_RS15415	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S101441_RS15420	COG3874	Sporulation protein YtfJ
S101441_RS15430	COG1714	RDD family
S101441_RS15435	COG0616	signal peptide processing
S101441_RS15440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101441_RS15455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S101441_RS15460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101441_RS15470	COG0301	tRNA thio-modification
S101441_RS15475	COG1104	cysteine desulfurase activity
S101441_RS15480	COG1114	Component of the transport system for branched-chain amino acids
S101441_RS15485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S101441_RS15490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101441_RS15495	COG1309	transcriptional regulator
S101441_RS15500	COG1956	GAF domain-containing protein
S101441_RS15515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S101441_RS15520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101441_RS15530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101441_RS15535	COG0454	-acetyltransferase
S101441_RS15540	COG0517	IMP dehydrogenase activity
S101441_RS15545	COG0123	including yeast histone deacetylase and acetoin utilization protein
S101441_RS15550	COG1360	Flagellar Motor Protein
S101441_RS15555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101441_RS15560	COG1609	Transcriptional regulator
S101441_RS15565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S101441_RS15565	COG1605	Chorismate mutase
S101441_RS15570	COG3118	belongs to the thioredoxin family
S101441_RS15575	COG4980	gas vesicle protein
S101441_RS15580	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101441_RS15585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S101441_RS15590	COG1674	ftsk spoiiie
S101441_RS15595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101441_RS15600	COG4848	Belongs to the UPF0354 family
S101441_RS15605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS15615	COG1363	Peptidase, m42
S101441_RS15620	COG5584	Small secreted protein
S101441_RS15625	COG0281	malic enzyme
S101441_RS15630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS15635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101441_RS15645	COG0510	thiamine kinase activity
S101441_RS15650	COG1523	belongs to the glycosyl hydrolase 13 family
S101441_RS15655	COG1597	lipid kinase activity
S101441_RS15665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101441_RS15670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101441_RS15675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101441_RS15680	COG2252	PERMEase
S101441_RS15685	COG4473	ABC transporter
S101441_RS15690	COG1131	(ABC) transporter
S101441_RS15695	COG1349	DNA-binding transcription factor activity
S101441_RS15700	COG1187	pseudouridine synthase activity
S101441_RS15705	COG2244	polysaccharide biosynthetic process
S101441_RS15710	COG2081	HI0933 family
S101441_RS15715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S101441_RS15725	COG5578	integral membrane protein
S101441_RS15730	COG0673	inositol 2-dehydrogenase activity
S101441_RS15735	COG1653	transport
S101441_RS15740	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101441_RS15745	COG4209	transmembrane transport
S101441_RS15755	COG1653	transport
S101441_RS15760	COG0395	ABC-type sugar transport system, permease component
S101441_RS15765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101441_RS15770	COG2124	cytochrome p450
S101441_RS15775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S101441_RS15785	COG0156	8-amino-7-oxononanoate synthase activity
S101441_RS15790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101441_RS15800	COG1073	alpha beta
S101441_RS15805	COG1609	Transcriptional regulator
S101441_RS15810	COG1653	transport
S101441_RS15815	COG1175	transmembrane transport
S101441_RS15820	COG0395	ABC-type sugar transport system, permease component
S101441_RS15825	COG1486	melibiose metabolic process
S101441_RS15830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101441_RS15835	COG0495	leucyl-tRNA aminoacylation
S101441_RS15845	COG1366	Belongs to the anti-sigma-factor antagonist family
S101441_RS15845	COG2202	Pas domain
S101441_RS15850	COG2814	Major facilitator Superfamily
S101441_RS15860	COG0577	efflux transmembrane transporter activity
S101441_RS15865	COG1136	(ABC) transporter
S101441_RS15870	COG2205	protein histidine kinase activity
S101441_RS15875	COG0745	RESPONSE REGULATOR receiver
S101441_RS15880	COG0577	efflux transmembrane transporter activity
S101441_RS15885	COG1136	(ABC) transporter
S101441_RS15900	COG1131	(ABC) transporter
S101441_RS15905	COG1725	Transcriptional regulator
S101441_RS15915	COG1242	4 iron, 4 sulfur cluster binding
S101441_RS15920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S101441_RS15930	COG2267	carboxylic ester hydrolase activity
S101441_RS15935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S101441_RS15940	COG1113	amino acid transport
S101441_RS15945	COG0367	asparagine synthase
S101441_RS15950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S101441_RS15955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S101441_RS15965	COG1506	peptidase
S101441_RS15970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101441_RS15975	COG1116	anion transmembrane transporter activity
S101441_RS15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101441_RS15985	COG0494	nUDIX hydrolase
S101441_RS15990	COG4824	toxin secretion phage lysis holin
S101441_RS15995	COG0783	Belongs to the Dps family
S101441_RS16010	COG1854	S-ribosylhomocysteine lyase activity
S101441_RS16015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S101441_RS16020	COG0288	reversible hydration of carbon dioxide
S101441_RS16025	COG0254	rRNA binding
S101441_RS16030	COG1271	oxidase subunit
S101441_RS16035	COG1294	oxidase, subunit
S101441_RS16045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101441_RS16050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101441_RS16050	COG1321	iron dependent repressor
S101441_RS16055	COG1121	(ABC) transporter
S101441_RS16060	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101441_RS16070	COG4948	Mandelate Racemase Muconate Lactonizing
S101441_RS16075	COG0318	PFAM AMP-dependent synthetase and ligase
S101441_RS16080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S101441_RS16085	COG0596	Alpha beta hydrolase
S101441_RS16090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S101441_RS16095	COG1169	isochorismate synthase
S101441_RS16105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101441_RS16110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101441_RS16115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101441_RS16120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101441_RS16125	COG0438	transferase activity, transferring glycosyl groups
S101441_RS16135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101441_RS16140	COG0438	transferase activity, transferring glycosyl groups
S101441_RS16145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101441_RS16150	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S101441_RS16155	COG0058	SHG alpha-glucan phosphorylase activity
S101441_RS16160	COG0297	glycogen (starch) synthase activity
S101441_RS16165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101441_RS16170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101441_RS16175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S101441_RS16300	COG3859	Proton-coupled thiamine transporter YuaJ
S101441_RS16305	COG1247	-acetyltransferase
S101441_RS16310	COG2268	Band 7 protein
S101441_RS16315	COG1585	Membrane protein implicated in regulation of membrane protease activity
S101441_RS16320	COG2318	DinB family
S101441_RS16335	COG1454	alcohol dehydrogenase
S101441_RS16340	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS16345	COG1510	regulation of RNA biosynthetic process
S101441_RS16355	COG0569	domain protein
S101441_RS16360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101441_RS16365	COG4682	membrane
S101441_RS16370	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101441_RS16375	COG0477	Major facilitator Superfamily
S101441_RS16380	COG5553	Cysteine dioxygenase type I
S101441_RS16390	COG1968	undecaprenyl-diphosphatase activity
S101441_RS16395	COG0628	permease
S101441_RS16400	COG0673	inositol 2-dehydrogenase activity
S101441_RS16405	COG4806	L-rhamnose isomerase
S101441_RS16410	COG3254	rhamnose metabolic process
S101441_RS16415	COG1070	Carbohydrate kinase
S101441_RS16420	COG1349	DNA-binding transcription factor activity
S101441_RS16440	COG0840	transmembrane signaling receptor activity
S101441_RS16445	COG0840	transmembrane signaling receptor activity
S101441_RS16450	COG0840	transmembrane signaling receptor activity
S101441_RS16465	COG0432	Pfam Uncharacterised protein family UPF0047
S101441_RS16470	COG0366	Alpha amylase catalytic
S101441_RS16475	COG1253	flavin adenine dinucleotide binding
S101441_RS16480	COG2738	Putative neutral zinc metallopeptidase
S101441_RS16495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S101441_RS16510	COG0166	Belongs to the GPI family
S101441_RS16515	COG1979	alcohol dehydrogenase
S101441_RS16520	COG1979	alcohol dehydrogenase
S101441_RS16525	COG2155	Conserved Protein
S101441_RS16530	COG1098	S1 RNA binding domain
S101441_RS16535	COG0436	Aminotransferase
S101441_RS16540	COG1522	sequence-specific DNA binding
S101441_RS16545	COG2267	carboxylic ester hydrolase activity
S101441_RS16555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S101441_RS16560	COG2205	protein histidine kinase activity
S101441_RS16570	COG5018	Exonuclease
S101441_RS16580	COG2814	Major facilitator Superfamily
S101441_RS16585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101441_RS16590	COG3011	Protein conserved in bacteria
S101441_RS16600	COG3290	protein histidine kinase activity
S101441_RS16605	COG4565	transcriptional regulatory protein
S101441_RS16610	COG1744	ABC transporter substrate-binding protein PnrA-like
S101441_RS16615	COG3845	ABC transporter
S101441_RS16620	COG4603	Belongs to the binding-protein-dependent transport system permease family
S101441_RS16625	COG1079	Belongs to the binding-protein-dependent transport system permease family
S101441_RS16630	COG3493	citrate carrier protein
S101441_RS16640	COG2111	Na H antiporter
S101441_RS16640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101441_RS16645	COG2111	Na H antiporter
S101441_RS16650	COG1006	Multisubunit Na H antiporter MnhC subunit
S101441_RS16655	COG0651	ATP synthesis coupled electron transport
S101441_RS16660	COG1863	multisubunit Na H antiporter MnhE subunit
S101441_RS16665	COG2212	antiporter activity
S101441_RS16670	COG1320	monovalent cation:proton antiporter activity
S101441_RS16675	COG2050	protein possibly involved in aromatic compounds catabolism
S101441_RS16680	COG2197	response regulator
S101441_RS16685	COG4585	Histidine kinase
S101441_RS16695	COG0142	geranyltranstransferase activity
S101441_RS16710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S101441_RS16715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S101441_RS16720	COG1335	isochorismatase
S101441_RS16725	COG5506	Protein of unknown function (DUF1694)
S101441_RS16740	COG0628	permease
S101441_RS16755	COG1418	mRNA catabolic process
S101441_RS16760	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS16770	COG1511	domain protein
S101441_RS16775	COG0433	COG0433 Predicted ATPase
S101441_RS16775	COG1674	ftsk spoiiie
S101441_RS16780	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101441_RS16785	COG5417	Belongs to the EsaB family
S101441_RS16790	COG4842	Belongs to the WXG100 family
S101441_RS16800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101441_RS16800	COG2508	Transcriptional regulator
S101441_RS16805	COG0686	Belongs to the AlaDH PNT family
S101441_RS16810	COG5634	Uncharacterized conserved protein (DUF2278)
S101441_RS16815	COG3251	PFAM MbtH domain protein
S101441_RS16820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS16825	COG3433	isochorismatase activity
S101441_RS16825	COG1535	isochorismatase
S101441_RS16830	COG1021	2,3-dihydroxybenzoate-AMP ligase
S101441_RS16835	COG1169	isochorismate synthase
S101441_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS16845	COG2819	hydrolase of the alpha beta superfamily
S101441_RS16850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101441_RS16855	COG1268	BioY protein
S101441_RS16860	COG2056	Na+-H+ antiporter family
S101441_RS16865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101441_RS16870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S101441_RS16875	COG3584	3D domain protein
S101441_RS16890	COG1252	NADH dehydrogenase
S101441_RS16895	COG0492	ferredoxin-NADP+ reductase activity
S101441_RS16905	COG0516	GMP reductase activity
S101441_RS16915	COG0456	acetyltransferase
S101441_RS16920	COG0316	Belongs to the HesB IscA family
S101441_RS16925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S101441_RS16930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101441_RS16940	COG4844	belongs to the
S101441_RS16945	COG1252	NADH dehydrogenase
S101441_RS16950	COG4837	Protein of unknown function (DUF1462)
S101441_RS16955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S101441_RS16960	COG0823	Involved in the tonB-independent uptake of proteins
S101441_RS16960	COG4946	Tricorn protease homolog
S101441_RS16960	COG1506	peptidase
S101441_RS16965	COG0083	homoserine kinase activity
S101441_RS16970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S101441_RS16975	COG0460	homoserine dehydrogenase
S101441_RS16980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101441_RS16985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101441_RS16990	COG0647	UMP catabolic process
S101441_RS16995	COG2445	Protein of unknown function DUF86
S101441_RS17000	COG4470	Protein conserved in bacteria
S101441_RS17010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S101441_RS17015	COG0739	heme binding
S101441_RS17025	COG3377	Domain of unknown function (DUF1805)
S101441_RS17030	COG0737	Belongs to the 5'-nucleotidase family
S101441_RS17035	COG0730	response to heat
S101441_RS17040	COG1801	Protein of unknown function DUF72
S101441_RS17050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101441_RS17055	COG2508	Transcriptional regulator
S101441_RS17060	COG2233	PERMEase
S101441_RS17070	COG3648	Uricase
S101441_RS17070	COG3195	allantoin biosynthetic process
S101441_RS17075	COG2351	hydroxyisourate hydrolase activity
S101441_RS17090	COG2080	2 iron, 2 sulfur cluster binding
S101441_RS17095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S101441_RS17100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S101441_RS17105	COG2068	MobA-Related Protein
S101441_RS17110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S101441_RS17115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S101441_RS17120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101441_RS17125	COG2356	endonuclease I
S101441_RS17130	COG3842	ATPase activity
S101441_RS17135	COG2188	Transcriptional regulator
S101441_RS17140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101441_RS17150	COG1175	transmembrane transport
S101441_RS17155	COG1653	transport
S101441_RS17160	COG2222	sugar isomerase
S101441_RS17165	COG0322	excinuclease ABC activity
S101441_RS17170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101441_RS17190	COG0346	lactoylglutathione lyase activity
S101441_RS17195	COG0640	Transcriptional regulator
S101441_RS17205	COG5444	nuclease activity
S101441_RS17215	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS17215	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS17220	COG4824	toxin secretion phage lysis holin
S101441_RS17255	COG3953	SLT domain
S101441_RS17255	COG5412	phage tail tape measure protein
S101441_RS17350	COG0582	viral genome integration into host DNA
S101441_RS17430	COG3800	Transcriptional regulator
S101441_RS17430	COG1396	sequence-specific DNA binding
S101441_RS17450	COG0719	Fe-S assembly protein
S101441_RS17455	COG0822	iron-sulfur transferase activity
S101441_RS17460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101441_RS17465	COG0719	Fe-S assembly protein
S101441_RS17470	COG0396	ATPase activity
S101441_RS17485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101441_RS17490	COG1464	Belongs to the NlpA lipoprotein family
S101441_RS17495	COG2011	ABC-type metal ion transport system permease component
S101441_RS17500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101441_RS17510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101441_RS17515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101441_RS17525	COG0509	glycine decarboxylation via glycine cleavage system
S101441_RS17530	COG1393	Belongs to the ArsC family
S101441_RS17535	COG1960	acyl-CoA dehydrogenase activity
S101441_RS17540	COG0183	Belongs to the thiolase family
S101441_RS17545	COG1024	Enoyl-CoA hydratase
S101441_RS17545	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101441_RS17555	COG0506	proline dehydrogenase activity
S101441_RS17565	COG5577	PFAM Coat F domain
S101441_RS17570	COG1846	Transcriptional regulator
S101441_RS17575	COG0477	Major facilitator Superfamily
S101441_RS17580	COG1942	4-Oxalocrotonate Tautomerase
S101441_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS17590	COG0583	DNA-binding transcription factor activity
S101441_RS17600	COG1120	ATPase activity
S101441_RS17620	COG1131	(ABC) transporter
S101441_RS17665	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS17670	COG0783	Belongs to the Dps family
S101441_RS17680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101441_RS17685	COG0745	RESPONSE REGULATOR receiver
S101441_RS17690	COG2205	protein histidine kinase activity
S101441_RS17690	COG2770	Histidine kinase
S101441_RS17700	COG1309	transcriptional regulator
S101441_RS17705	COG0114	fumarate hydratase activity
S101441_RS17715	COG0697	spore germination
S101441_RS17720	COG0814	amino acid
S101441_RS17730	COG2197	response regulator
S101441_RS17735	COG4585	Histidine kinase
S101441_RS17740	COG4758	membrane
S101441_RS17745	COG3595	metallopeptidase activity
S101441_RS17750	COG1842	Phage shock protein A
S101441_RS17755	COG4758	membrane
S101441_RS17760	COG2814	Major facilitator Superfamily
S101441_RS17765	COG2096	Adenosyltransferase
S101441_RS17770	COG1120	ATPase activity
S101441_RS17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS17780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS17790	COG3386	PFAM SMP-30 Gluconolaconase
S101441_RS17795	COG2205	protein histidine kinase activity
S101441_RS17800	COG0745	RESPONSE REGULATOR receiver
S101441_RS17810	COG1191	sigma factor activity
S101441_RS17820	COG2140	Oxalate decarboxylase
S101441_RS17830	COG0577	efflux transmembrane transporter activity
S101441_RS17835	COG1136	(ABC) transporter
S101441_RS17840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101441_RS17845	COG1120	ATPase activity
S101441_RS17850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101441_RS17860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS17870	COG0531	amino acid
S101441_RS17885	COG1988	membrane-bound metal-dependent
S101441_RS17890	COG1368	sulfuric ester hydrolase activity
S101441_RS17895	COG1910	domain protein
S101441_RS17900	COG0725	ABC transporter, periplasmic molybdate-binding protein
S101441_RS17905	COG4149	molybdate abc transporter
S101441_RS17910	COG0656	L-ascorbic acid biosynthetic process
S101441_RS17920	COG0025	NhaP-type Na H and K H
S101441_RS17925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101441_RS17930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101441_RS17935	COG3973	AAA domain
S101441_RS17945	COG2860	membrane
S101441_RS17950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S101441_RS17955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S101441_RS17960	COG2217	Heavy metal translocating P-type atpase
S101441_RS17970	COG2217	Heavy metal translocating P-type atpase
S101441_RS17975	COG2608	mercury ion transmembrane transporter activity
S101441_RS17980	COG1937	Protein conserved in bacteria
S101441_RS17985	COG0673	inositol 2-dehydrogenase activity
S101441_RS17995	COG1289	transmembrane transporter activity
S101441_RS18005	COG2076	Multidrug Resistance protein
S101441_RS18010	COG1309	transcriptional regulator
S101441_RS18015	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS18025	COG5444	nuclease activity
S101441_RS18040	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101441_RS18040	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS18045	COG4824	toxin secretion phage lysis holin
S101441_RS18070	COG3942	CHAP domain
S101441_RS18070	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101441_RS18185	COG0582	viral genome integration into host DNA
S101441_RS18295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101441_RS18300	COG0557	exoribonuclease II activity
S101441_RS18305	COG1647	Serine aminopeptidase, S33
S101441_RS18310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101441_RS18315	COG0596	Alpha beta hydrolase
S101441_RS18320	COG1476	TRANSCRIPTIONal
S101441_RS18325	COG1396	sequence-specific DNA binding
S101441_RS18330	COG1396	sequence-specific DNA binding
S101441_RS18335	COG1733	regulation of RNA biosynthetic process
S101441_RS18340	COG0840	transmembrane signaling receptor activity
S101441_RS18345	COG1174	glycine betaine transport
S101441_RS18350	COG1732	Glycine betaine
S101441_RS18355	COG1174	glycine betaine transport
S101441_RS18360	COG1125	glycine betaine transport
S101441_RS18360	COG0517	IMP dehydrogenase activity
S101441_RS18365	COG1510	regulation of RNA biosynthetic process
S101441_RS18370	COG1174	glycine betaine transport
S101441_RS18375	COG1732	Glycine betaine
S101441_RS18380	COG1174	glycine betaine transport
S101441_RS18385	COG1125	glycine betaine transport
S101441_RS18385	COG0517	IMP dehydrogenase activity
S101441_RS18390	COG1510	regulation of RNA biosynthetic process
S101441_RS18395	COG2095	MarC family integral membrane protein
S101441_RS18405	COG3064	Membrane
S101441_RS18410	COG4640	response to antibiotic
S101441_RS18415	COG0456	acetyltransferase
S101441_RS18420	COG0148	phosphopyruvate hydratase activity
S101441_RS18425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S101441_RS18430	COG0149	triose-phosphate isomerase activity
S101441_RS18435	COG0126	phosphoglycerate kinase activity
S101441_RS18440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101441_RS18445	COG2390	Transcriptional regulator
S101441_RS18450	COG2814	Major facilitator Superfamily
S101441_RS18455	COG1609	Transcriptional regulator
S101441_RS18460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101441_RS18470	COG0583	DNA-binding transcription factor activity
S101441_RS18475	COG0697	spore germination
S101441_RS18480	COG1113	amino acid transport
S101441_RS18490	COG1556	Lactate utilization protein
S101441_RS18495	COG1139	Iron-sulfur cluster binding protein
S101441_RS18500	COG0247	lactate metabolic process
S101441_RS18515	COG2197	response regulator
S101441_RS18520	COG4585	Histidine kinase
S101441_RS18525	COG0842	Transport permease protein
S101441_RS18530	COG1131	(ABC) transporter
S101441_RS18535	COG0596	Alpha beta hydrolase
S101441_RS18540	COG2208	phosphoserine phosphatase activity
S101441_RS18545	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S101441_RS18550	COG1874	Beta-galactosidase
S101441_RS18555	COG3833	ABC-type maltose transport systems, permease component
S101441_RS18560	COG1175	transmembrane transport
S101441_RS18565	COG2182	Extracellular solute-binding protein
S101441_RS18570	COG1609	Transcriptional regulator
S101441_RS18575	COG2186	Transcriptional regulator
S101441_RS18580	COG1620	l-lactate permease
S101441_RS18595	COG5039	Polysaccharide pyruvyl transferase
S101441_RS18600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101441_RS18605	COG0110	maltose O-acetyltransferase activity
S101441_RS18610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S101441_RS18615	COG2244	polysaccharide biosynthetic process
S101441_RS18620	COG1216	Glycosyl transferase, family 2
S101441_RS18625	COG5039	Polysaccharide pyruvyl transferase
S101441_RS18630	COG1216	Glycosyl transferase, family 2
S101441_RS18640	COG0438	transferase activity, transferring glycosyl groups
S101441_RS18645	COG1215	transferase activity, transferring glycosyl groups
S101441_RS18650	COG0438	transferase activity, transferring glycosyl groups
S101441_RS18655	COG1086	Polysaccharide biosynthesis protein
S101441_RS18660	COG0489	protein tyrosine kinase activity
S101441_RS18665	COG3944	biosynthesis protein
S101441_RS18670	COG1396	sequence-specific DNA binding
S101441_RS18675	COG2272	Belongs to the type-B carboxylesterase lipase family
S101441_RS18685	COG3479	Phenolic acid decarboxylase
S101441_RS18700	COG1794	racemase activity, acting on amino acids and derivatives
S101441_RS18710	COG1621	beta-fructofuranosidase activity
S101441_RS18715	COG1621	beta-fructofuranosidase activity
S101441_RS18720	COG0531	amino acid
S101441_RS18725	COG1309	transcriptional regulator
S101441_RS18730	COG2076	Multidrug Resistance protein
S101441_RS18735	COG2076	Multidrug Resistance protein
S101441_RS18750	COG0740	serine-type endopeptidase activity
S101441_RS18755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101441_RS18760	COG0366	Alpha amylase catalytic
S101441_RS18765	COG1554	hydrolase, family 65, central catalytic
S101441_RS18770	COG5521	maltodextrose utilization protein MalA
S101441_RS18775	COG3833	ABC-type maltose transport systems, permease component
S101441_RS18780	COG1175	transmembrane transport
S101441_RS18785	COG2182	Extracellular solute-binding protein
S101441_RS18790	COG0366	Alpha amylase catalytic
S101441_RS18795	COG1609	Transcriptional regulator
S101441_RS18800	COG1611	Belongs to the LOG family
S101441_RS18805	COG1694	Mazg nucleotide pyrophosphohydrolase
S101441_RS18810	COG0659	secondary active sulfate transmembrane transporter activity
S101441_RS18815	COG0288	reversible hydration of carbon dioxide
S101441_RS18820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101441_RS18825	COG0577	efflux transmembrane transporter activity
S101441_RS18830	COG1136	(ABC) transporter
S101441_RS18835	COG5002	protein histidine kinase activity
S101441_RS18840	COG0745	RESPONSE REGULATOR receiver
S101441_RS18850	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S101441_RS18855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS18860	COG1481	regulation of sporulation
S101441_RS18865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S101441_RS18870	COG1660	Displays ATPase and GTPase activities
S101441_RS18875	COG1051	belongs to the nudix hydrolase family
S101441_RS18880	COG0492	ferredoxin-NADP+ reductase activity
S101441_RS18885	COG3883	PFAM NLP P60 protein
S101441_RS18885	COG0791	NLP P60 protein
S101441_RS18890	COG0457	Tetratricopeptide repeat
S101441_RS18895	COG1132	(ABC) transporter
S101441_RS18915	COG0140	phosphoribosyl-ATP diphosphatase activity
S101441_RS18915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S101441_RS18920	COG0107	imidazoleglycerol-phosphate synthase activity
S101441_RS18925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S101441_RS18930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S101441_RS18935	COG0131	Imidazoleglycerol-phosphate dehydratase
S101441_RS18940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S101441_RS18945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S101441_RS18950	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S101441_RS18955	COG4990	cell redox homeostasis
S101441_RS18960	COG5297	Belongs to the glycosyl hydrolase family 6
S101441_RS18970	COG0110	maltose O-acetyltransferase activity
S101441_RS18975	COG0546	phosphoglycolate phosphatase activity
S101441_RS18980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S101441_RS18985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101441_RS18990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S101441_RS18995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101441_RS19000	COG0363	glucosamine-6-phosphate deaminase activity
S101441_RS19005	COG2188	Transcriptional regulator
S101441_RS19010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101441_RS19025	COG1950	PFAM Membrane protein of
S101441_RS19030	COG1983	PspC domain protein
S101441_RS19035	COG3595	metallopeptidase activity
S101441_RS19050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101441_RS19055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101441_RS19060	COG0556	nucleotide-excision repair
S101441_RS19065	COG4897	Protein conserved in bacteria
S101441_RS19070	COG0574	Belongs to the PEP-utilizing enzyme family
S101441_RS19070	COG3848	Pyruvate phosphate dikinase
S101441_RS19075	COG1309	transcriptional regulator
S101441_RS19080	COG2814	Major facilitator Superfamily
S101441_RS19085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101441_RS19095	COG0793	Belongs to the peptidase S41A family
S101441_RS19095	COG3409	Peptidoglycan-binding domain 1 protein
S101441_RS19100	COG2177	Part of the ABC transporter FtsEX involved in
S101441_RS19105	COG2884	Cell division ATP-binding protein ftsE
S101441_RS19110	COG2010	Cytochrome c
S101441_RS19115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS19125	COG0653	protein targeting
S101441_RS19135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S101441_RS19150	COG1516	flagellar protein fliS
S101441_RS19155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S101441_RS19160	COG1334	flagellar protein FlaG
S101441_RS19165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101441_RS19170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S101441_RS19175	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S101441_RS19185	COG0791	NLP P60 protein
S101441_RS19190	COG0561	phosphatase activity
S101441_RS19195	COG1316	TRANSCRIPTIONal
S101441_RS19220	COG1482	cell wall glycoprotein biosynthetic process
S101441_RS19225	COG4193	domain, Protein
S101441_RS19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101441_RS19235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S101441_RS19240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S101441_RS19245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101441_RS19250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101441_RS19250	COG0463	Glycosyl transferase, family 2
S101441_RS19265	COG1682	transport, permease protein
S101441_RS19270	COG1134	teichoic acid transport
S101441_RS19280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101441_RS19285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S101441_RS19300	COG2244	polysaccharide biosynthetic process
S101441_RS19305	COG0438	transferase activity, transferring glycosyl groups
S101441_RS19305	COG0297	glycogen (starch) synthase activity
S101441_RS19310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101441_RS19320	COG3307	-O-antigen
S101441_RS19325	COG3206	protein involved in exopolysaccharide biosynthesis
S101441_RS19330	COG1215	transferase activity, transferring glycosyl groups
S101441_RS19335	COG0438	transferase activity, transferring glycosyl groups
S101441_RS19340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101441_RS19350	COG1131	(ABC) transporter
S101441_RS19385	COG1316	TRANSCRIPTIONal
S101441_RS19390	COG1739	Uncharacterized protein family UPF0029
S101441_RS19395	COG4585	Histidine kinase
S101441_RS19400	COG2197	response regulator
S101441_RS19405	COG1307	EDD domain protein, DegV family
S101441_RS19410	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S101441_RS19420	COG1040	competence protein
S101441_RS19430	COG2747	anti-sigma28 factor FlgM
S101441_RS19435	COG3418	PFAM FlgN family protein
S101441_RS19440	COG1256	bacterial-type flagellum assembly
S101441_RS19440	COG4786	Flagellar basal body rod
S101441_RS19445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101441_RS19465	COG2843	Capsule synthesis protein
S101441_RS19475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101441_RS19490	COG1609	Transcriptional regulator
S101441_RS19495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101441_RS19500	COG1869	D-ribose catabolic process
S101441_RS19505	COG1129	ABC transporter
S101441_RS19510	COG1172	Belongs to the binding-protein-dependent transport system permease family
S101441_RS19515	COG1879	ABC-type sugar transport system periplasmic component
S101441_RS19520	COG3103	Sh3 type 3 domain protein
S101441_RS19530	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101441_RS19535	COG3527	Alpha-acetolactate decarboxylase
S101441_RS19540	COG0028	Belongs to the TPP enzyme family
S101441_RS19545	COG0583	DNA-binding transcription factor activity
S101441_RS19565	COG5337	Spore coat protein CotH
S101441_RS19575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101441_RS19585	COG0405	Gamma-glutamyltransferase
S101441_RS19590	COG1522	sequence-specific DNA binding
S101441_RS19595	COG2059	Chromate
S101441_RS19600	COG2059	Chromate
S101441_RS19610	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101441_RS19615	COG0583	DNA-binding transcription factor activity
S101441_RS19645	COG5444	nuclease activity
S101441_RS19660	COG3878	Protein conserved in bacteria
S101441_RS19665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101441_RS19670	COG4464	protein tyrosine phosphatase activity
S101441_RS19675	COG0489	protein tyrosine kinase activity
S101441_RS19680	COG3944	biosynthesis protein
S101441_RS19690	COG4715	Zinc finger, swim domain protein
S101441_RS19695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101441_RS19705	COG0561	phosphatase activity
S101441_RS19710	COG1349	DNA-binding transcription factor activity
S101441_RS19715	COG0629	single-stranded DNA binding
S101441_RS19730	COG3764	Sortase (surface protein transpeptidase)
S101441_RS19735	COG0745	RESPONSE REGULATOR receiver
S101441_RS19735	COG2972	Histidine kinase
S101441_RS19740	COG1970	mechanosensitive ion channel activity
S101441_RS19745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101441_RS19750	COG0457	Tetratricopeptide repeat
S101441_RS19755	COG4786	Flagellar basal body rod
S101441_RS19760	COG4786	Flagellar basal body rod
S101441_RS19765	COG1077	Cell shape determining protein MreB Mrl
S101441_RS19770	COG1609	Transcriptional regulator
S101441_RS19780	COG1846	Transcriptional regulator
S101441_RS19785	COG2814	Major facilitator Superfamily
S101441_RS19790	COG3420	alginic acid biosynthetic process
S101441_RS19795	COG1953	Uracil, thiamine, allantoin
S101441_RS19800	COG0477	Major facilitator Superfamily
S101441_RS19805	COG1335	isochorismatase
S101441_RS19815	COG0004	ammonium transporteR
S101441_RS19820	COG0347	Belongs to the P(II) protein family
S101441_RS19825	COG0671	phosphoesterase, PA-phosphatase related
S101441_RS19835	COG0739	heme binding
S101441_RS19840	COG1247	-acetyltransferase
S101441_RS19850	COG2089	acid synthase
S101441_RS19860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101441_RS19865	COG0789	Transcriptional regulator
S101441_RS19880	COG1959	2 iron, 2 sulfur cluster binding
S101441_RS19885	COG0804	urea catabolic process
S101441_RS19890	COG0832	Belongs to the urease beta subunit family
S101441_RS19895	COG0831	urea catabolic process
S101441_RS19910	COG3237	CsbD-like
S101441_RS19915	COG1994	Peptidase M50
S101441_RS19920	COG0457	Tetratricopeptide repeat
S101441_RS19930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S101441_RS19935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S101441_RS19945	COG2304	oxidoreductase activity
S101441_RS19955	COG2304	oxidoreductase activity
S101441_RS19960	COG2385	sporulation resulting in formation of a cellular spore
S101441_RS19965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101441_RS19975	COG4836	Membrane
S101441_RS19985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101441_RS19990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101441_RS19995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101441_RS20000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S101441_RS20005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101441_RS20010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101441_RS20020	COG0356	it plays a direct role in the translocation of protons across the membrane
S101441_RS20030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101441_RS20035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101441_RS20040	COG4475	Protein of unknown function (DUF436)
S101441_RS20045	COG0698	ribose 5-phosphate isomerase
S101441_RS20050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101441_RS20055	COG1971	Probably functions as a manganese efflux pump
S101441_RS20060	COG0009	L-threonylcarbamoyladenylate synthase
S101441_RS20065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S101441_RS20085	COG2890	protein-(glutamine-N5) methyltransferase activity
S101441_RS20090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101441_RS20095	COG0346	lactoylglutathione lyase activity
S101441_RS20100	COG0789	Transcriptional regulator
S101441_RS20105	COG0679	Auxin Efflux Carrier
S101441_RS20110	COG0281	malic enzyme
S101441_RS20115	COG1435	thymidine kinase activity
S101441_RS20125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S101441_RS20130	COG1494	fructose-1,6-bisphosphatase
S101441_RS20135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101441_RS20140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S101441_RS20145	COG0191	fructose-bisphosphate aldolase activity
S101441_RS20150	COG2204	response regulator
S101441_RS20160	COG4821	SIS domain
S101441_RS20170	COG0504	CTP synthase activity
S101441_RS20175	COG3343	RNA polymerase activity
S101441_RS20180	COG1960	acyl-CoA dehydrogenase activity
S101441_RS20185	COG2181	nitrate reductase activity
S101441_RS20185	COG0247	lactate metabolic process
S101441_RS20190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101441_RS20195	COG4294	response to UV
S101441_RS20210	COG0018	arginyl-trna synthetase
S101441_RS20215	COG4506	Protein conserved in bacteria
S101441_RS20230	COG0535	radical SAM domain protein
S101441_RS20240	COG1131	(ABC) transporter
S101441_RS20245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101441_RS20250	COG0612	Peptidase, M16
S101441_RS20255	COG0612	Peptidase, M16
S101441_RS20265	COG3391	amine dehydrogenase activity
S101441_RS20280	COG0457	Tetratricopeptide repeat
S101441_RS20295	COG0010	Belongs to the arginase family
S101441_RS20300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S101441_RS20305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101441_RS20320	COG1994	Peptidase M50
S101441_RS20325	COG1942	4-Oxalocrotonate Tautomerase
S101441_RS20330	COG1846	Transcriptional regulator
S101441_RS20335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101441_RS20340	COG0477	Major facilitator Superfamily
S101441_RS20345	COG1959	2 iron, 2 sulfur cluster binding
S101441_RS20350	COG3465	dGTPase activity
S101441_RS20355	COG1078	dGTPase activity
S101441_RS20360	COG4844	belongs to the
S101441_RS20370	COG0697	spore germination
S101441_RS20375	COG0095	Lipoate-protein ligase
S101441_RS20380	COG0583	DNA-binding transcription factor activity
S101441_RS20385	COG0280	phosphate acetyltransferase
S101441_RS20390	COG3253	May function as heme-dependent peroxidase
S101441_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS20400	COG0436	Aminotransferase
S101441_RS20405	COG2814	Major facilitator Superfamily
S101441_RS20410	COG0151	Belongs to the GarS family
S101441_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS20420	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS20425	COG0077	Prephenate dehydratase
S101441_RS20435	COG2814	Major facilitator Superfamily
S101441_RS20440	COG0833	amino acid
S101441_RS20445	COG4187	Peptidase family M20/M25/M40
S101441_RS20450	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS20455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101441_RS20465	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S101441_RS20470	COG1091	dTDP-4-dehydrorhamnose reductase activity
S101441_RS20475	COG1088	dTDP-glucose 4,6-dehydratase activity
S101441_RS20480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S101441_RS20485	COG3980	spore coat polysaccharide biosynthesis protein
S101441_RS20490	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S101441_RS20495	COG2089	acid synthase
S101441_RS20500	COG0456	acetyltransferase
S101441_RS20505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101441_RS20510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101441_RS20515	COG0463	Glycosyl transferase, family 2
S101441_RS20530	COG2363	Small membrane protein
S101441_RS20535	COG2233	PERMEase
S101441_RS20545	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS20550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S101441_RS20555	COG1216	Glycosyl transferase, family 2
S101441_RS20560	COG0351	phosphomethylpyrimidine kinase
S101441_RS20570	COG1621	beta-fructofuranosidase activity
S101441_RS20575	COG1263	PTS System
S101441_RS20575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS20580	COG2116	formate transmembrane transporter activity
S101441_RS20585	COG3711	transcriptional antiterminator
S101441_RS20595	COG1404	Belongs to the peptidase S8 family
S101441_RS20600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101441_RS20605	COG0778	Nitroreductase
S101441_RS20610	COG0772	Belongs to the SEDS family
S101441_RS20625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101441_RS20630	COG1845	cytochrome c oxidase, subunit III
S101441_RS20635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101441_RS20640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101441_RS20645	COG2261	transglycosylase associated protein
S101441_RS20650	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S101441_RS20655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S101441_RS20660	COG2246	polysaccharide biosynthetic process
S101441_RS20665	COG1309	transcriptional regulator
S101441_RS20675	COG3162	membrane
S101441_RS20680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101441_RS20685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101441_RS20690	COG2837	iron assimilation
S101441_RS20695	COG2822	iron ion transport
S101441_RS20700	COG0672	)-iron permease
S101441_RS20705	COG0352	thiamine-phosphate diphosphorylase activity
S101441_RS20710	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S101441_RS20715	COG0583	DNA-binding transcription factor activity
S101441_RS20720	COG1380	Effector of murein hydrolase LrgA
S101441_RS20725	COG1346	cytolysis
S101441_RS20730	COG2814	Major facilitator Superfamily
S101441_RS20735	COG4895	conserved protein (DUF2196)
S101441_RS20740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S101441_RS20745	COG0346	lactoylglutathione lyase activity
S101441_RS20760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101441_RS20765	COG1404	Belongs to the peptidase S8 family
S101441_RS20770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101441_RS20770	COG1263	PTS System
S101441_RS20775	COG3711	transcriptional antiterminator
S101441_RS20785	COG1442	glycosyl transferase family 8
S101441_RS20790	COG5522	Integral membrane protein (intg_mem_TP0381)
S101441_RS20795	COG1846	Transcriptional regulator
S101441_RS20800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101441_RS20805	COG2234	aminopeptidase activity
S101441_RS20810	COG2357	RelA SpoT domain protein
S101441_RS20820	COG1575	Belongs to the MenA family. Type 1 subfamily
S101441_RS20835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101441_RS20840	COG1696	Membrane protein involved in D-alanine export
S101441_RS20845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101441_RS20850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S101441_RS20860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101441_RS20865	COG1486	melibiose metabolic process
S101441_RS20870	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101441_RS20875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101441_RS20880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101441_RS20885	COG3711	transcriptional antiterminator
S101441_RS20885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101441_RS20895	COG2094	Belongs to the DNA glycosylase MPG family
S101441_RS20900	COG0753	catalase activity
S101441_RS20905	COG2814	Major facilitator Superfamily
S101441_RS20910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101441_RS20915	COG1131	(ABC) transporter
S101441_RS20935	COG1595	DNA-templated transcription, initiation
S101441_RS20940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101441_RS20945	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101441_RS20950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101441_RS20955	COG4988	ABC transporter
S101441_RS20960	COG1294	oxidase, subunit
S101441_RS20965	COG1271	oxidase subunit
S101441_RS20970	COG3493	citrate carrier protein
S101441_RS20975	COG0501	Belongs to the peptidase M48B family
S101441_RS20985	COG0726	polysaccharide deacetylase
S101441_RS20990	COG3842	ATPase activity
S101441_RS20995	COG2508	Transcriptional regulator
S101441_RS21000	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS21005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101441_RS21015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101441_RS21030	COG2197	response regulator
S101441_RS21035	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101441_RS21045	COG4894	glucomannan catabolic process
S101441_RS21050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101441_RS21055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101441_RS21060	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS21065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101441_RS21070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101441_RS21075	COG2610	gluconate transmembrane transporter activity
S101441_RS21080	COG0500	methyltransferase
S101441_RS21085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101441_RS21100	COG0693	protein deglycase activity
S101441_RS21100	COG0753	catalase activity
S101441_RS21105	COG2851	Citrate transporter
S101441_RS21110	COG2273	Hydrolase Family 16
S101441_RS21115	COG3711	transcriptional antiterminator
S101441_RS21130	COG2270	Major facilitator Superfamily
S101441_RS21135	COG0513	Belongs to the DEAD box helicase family
S101441_RS21140	COG2755	lipolytic protein G-D-S-L family
S101441_RS21140	COG3401	FG-GAP repeat protein
S101441_RS21270	COG0589	response to stress
S101441_RS21275	COG2723	6-phospho-beta-galactosidase activity
S101441_RS21290	COG5444	nuclease activity
S101441_RS21310	COG0494	nUDIX hydrolase
S101441_RS21315	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S101441_RS21320	COG3507	Belongs to the glycosyl hydrolase 43 family
S101441_RS21325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S101441_RS21330	COG0833	amino acid
S101441_RS21335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S101441_RS21340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101441_RS21345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S101441_RS21350	COG2390	Transcriptional regulator
S101441_RS21360	COG3192	ethanolamine utilization protein
S101441_RS21365	COG2079	MmgE PrpD family protein
S101441_RS21370	COG1473	amidohydrolase
S101441_RS21375	COG1126	abc transporter atp-binding protein
S101441_RS21380	COG0765	amino acid transport
S101441_RS21385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101441_RS21390	COG0456	acetyltransferase
S101441_RS21395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101441_RS21400	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101441_RS21405	COG0561	phosphatase activity
S101441_RS21435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101441_RS21440	COG5294	Protein conserved in bacteria
S101441_RS21445	COG0577	efflux transmembrane transporter activity
S101441_RS21450	COG1136	(ABC) transporter
S101441_RS21455	COG2205	protein histidine kinase activity
S101441_RS21460	COG0745	RESPONSE REGULATOR receiver
S101441_RS21465	COG0191	fructose-bisphosphate aldolase activity
S101441_RS21470	COG1082	Xylose isomerase domain protein TIM barrel
S101441_RS21475	COG1082	Xylose isomerase domain protein TIM barrel
S101441_RS21480	COG0673	inositol 2-dehydrogenase activity
S101441_RS21485	COG2814	Major facilitator Superfamily
S101441_RS21490	COG1082	Xylose isomerase domain protein TIM barrel
S101441_RS21495	COG3962	Belongs to the TPP enzyme family
S101441_RS21500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101441_RS21515	COG1349	DNA-binding transcription factor activity
S101441_RS21520	COG0667	Aldo Keto reductase
S101441_RS21550	COG0326	Molecular chaperone. Has ATPase activity
S101441_RS21565	COG1309	transcriptional regulator
S101441_RS21570	COG1012	belongs to the aldehyde dehydrogenase family
S101441_RS21575	COG1714	RDD family
S101441_RS21585	COG1714	RDD family
S101441_RS21590	COG2311	Membrane
S101441_RS21595	COG1917	Cupin 2, conserved barrel domain protein
S101441_RS21600	COG1309	transcriptional regulator
S101441_RS21605	COG1028	Short-chain dehydrogenase reductase Sdr
S101441_RS21610	COG1846	Transcriptional regulator
S101441_RS21615	COG1380	Effector of murein hydrolase LrgA
S101441_RS21620	COG1346	cytolysis
S101441_RS21625	COG5039	Polysaccharide pyruvyl transferase
S101441_RS21630	COG1929	Belongs to the glycerate kinase type-1 family
S101441_RS21635	COG1802	Transcriptional regulator
S101441_RS21640	COG1070	Carbohydrate kinase
S101441_RS21645	COG2610	gluconate transmembrane transporter activity
S101441_RS21650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101441_RS21655	COG0450	alkyl hydroperoxide reductase
S101441_RS21660	COG3634	alkyl hydroperoxide reductase activity
S101441_RS21665	COG2723	6-phospho-beta-galactosidase activity
S101441_RS21670	COG2190	(PTS) system
S101441_RS21680	COG2188	Transcriptional regulator
S101441_RS21690	COG1131	(ABC) transporter
S101441_RS21695	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S101441_RS21710	COG0071	Belongs to the small heat shock protein (HSP20) family
S101441_RS21720	COG3773	Cell wall hydrolase
S101441_RS21745	COG0210	DNA helicase
S101441_RS21790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101441_RS21805	COG1063	alcohol dehydrogenase
S101441_RS21825	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S101441_RS21830	COG0456	acetyltransferase
S101441_RS21845	COG0010	Belongs to the arginase family
S101441_RS21850	COG0833	amino acid
S101441_RS21855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101441_RS21875	COG5658	integral membrane protein
S101441_RS21880	COG0640	Transcriptional regulator
S101441_RS21885	COG3829	transcription factor binding
S101441_RS21890	COG5002	protein histidine kinase activity
S101441_RS21895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101441_RS21900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101441_RS21905	COG4853	Protein conserved in bacteria
S101441_RS21910	COG4863	YycH protein
S101441_RS21915	COG5002	protein histidine kinase activity
S101441_RS21920	COG0745	RESPONSE REGULATOR receiver
S101441_RS21950	COG0346	lactoylglutathione lyase activity
S101441_RS21955	COG0305	Participates in initiation and elongation during chromosome replication
S101441_RS21970	COG3093	addiction module antidote protein HigA
S101441_RS21975	COG2807	transmembrane transport
S101441_RS21980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101441_RS21985	COG0359	binds to the 23S rRNA
S101441_RS21990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S101441_RS22010	COG1733	regulation of RNA biosynthetic process
S101441_RS22015	COG1227	inorganic diphosphatase activity
S101441_RS22035	COG4978	Transcriptional regulator
S101441_RS22035	COG0789	Transcriptional regulator
S101441_RS22045	COG4319	ketosteroid isomerase
S101441_RS22050	COG1357	PFAM Pentapeptide repeats (8 copies)
S101441_RS22055	COG2814	Major facilitator Superfamily
S101441_RS22060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101441_RS22065	COG1846	Transcriptional regulator
S101441_RS22070	COG2153	protein acetylation
S101441_RS22075	COG2364	Membrane
S101441_RS22090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101441_RS22100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S101441_RS22105	COG1331	Highly conserved protein containing a thioredoxin domain
S101441_RS22110	COG1266	CAAX protease self-immunity
S101441_RS22115	COG2814	Major facilitator Superfamily
S101441_RS22115	COG0477	Major facilitator Superfamily
S101441_RS22120	COG0110	maltose O-acetyltransferase activity
S101441_RS22125	COG0346	lactoylglutathione lyase activity
S101441_RS22135	COG0708	Exodeoxyribonuclease III
S101441_RS22140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S101441_RS22145	COG0629	single-stranded DNA binding
S101441_RS22150	COG0360	Binds together with S18 to 16S ribosomal RNA
S101441_RS22155	COG0012	GTP binding
S101441_RS22160	COG0243	molybdopterin cofactor binding
S101441_RS22165	COG4481	Protein conserved in bacteria
S101441_RS22170	COG3949	Membrane
S101441_RS22185	COG1475	DNA binding
S101441_RS22190	COG1192	Involved in chromosome partitioning
S101441_RS22200	COG1475	DNA binding
S101441_RS22205	COG0357	Ribosomal RNA small subunit methyltransferase G
S101441_RS22210	COG0445	tRNA wobble uridine modification
S101441_RS22215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S101441_RS22220	COG1847	R3H domain protein
S101441_RS22225	COG0706	membrane insertase activity
S101441_RS22230	COG0594	ribonuclease P activity
S101441_RS22250	COG0457	Tetratricopeptide repeat