locus-tag	class	description
ETK49_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ETK49_RS00010	COG0592	DNA-directed DNA polymerase activity
ETK49_RS00015	COG2501	S4 domain
ETK49_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ETK49_RS00030	COG0187	DNA topoisomerase II activity
ETK49_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ETK49_RS00070	COG0517	IMP dehydrogenase activity
ETK49_RS00070	COG0516	GMP reductase activity
ETK49_RS00075	COG1686	Belongs to the peptidase S11 family
ETK49_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ETK49_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ETK49_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ETK49_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
ETK49_RS00100	COG2610	gluconate transmembrane transporter activity
ETK49_RS00105	COG3835	regulator
ETK49_RS00120	COG1428	Deoxynucleoside kinase
ETK49_RS00125	COG1428	Deoxynucleoside kinase
ETK49_RS00130	COG1388	LysM domain
ETK49_RS00130	COG3858	chitin binding
ETK49_RS00135	COG1335	isochorismatase
ETK49_RS00140	COG0590	tRNA wobble adenosine to inosine editing
ETK49_RS00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ETK49_RS00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ETK49_RS00160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ETK49_RS00205	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ETK49_RS00210	COG3853	Toxic anion resistance protein (TelA)
ETK49_RS00215	COG1982	Orn Lys Arg decarboxylase major
ETK49_RS00220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ETK49_RS00225	COG3870	Protein conserved in bacteria
ETK49_RS00230	COG1728	Protein conserved in bacteria
ETK49_RS00235	COG0470	DNA polymerase III
ETK49_RS00240	COG1774	PSP1 C-terminal conserved region
ETK49_RS00245	COG4467	Involved in initiation control of chromosome replication
ETK49_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ETK49_RS00255	COG2827	Endonuclease containing a URI domain
ETK49_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ETK49_RS00265	COG2002	toxin-antitoxin pair type II binding
ETK49_RS00270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK49_RS00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK49_RS00275	COG0084	hydrolase, TatD family'
ETK49_RS00280	COG3584	3D domain protein
ETK49_RS00280	COG3583	domain protein
ETK49_RS00285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ETK49_RS00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ETK49_RS00300	COG4466	Protein conserved in bacteria
ETK49_RS00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ETK49_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK49_RS00320	COG0251	oxidation-reduction process
ETK49_RS00325	COG2088	sporulation resulting in formation of a cellular spore
ETK49_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ETK49_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ETK49_RS00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ETK49_RS00345	COG0193	aminoacyl-tRNA hydrolase activity
ETK49_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ETK49_RS00360	COG2002	toxin-antitoxin pair type II binding
ETK49_RS00365	COG2244	polysaccharide biosynthetic process
ETK49_RS00370	COG3956	TIGRFAM MazG family protein
ETK49_RS00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ETK49_RS00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ETK49_RS00395	COG1098	S1 RNA binding domain
ETK49_RS00410	COG2208	phosphoserine phosphatase activity
ETK49_RS00415	COG2304	oxidoreductase activity
ETK49_RS00420	COG0515	serine threonine protein kinase
ETK49_RS00425	COG0037	tRNA processing
ETK49_RS00430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ETK49_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETK49_RS00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ETK49_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ETK49_RS00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETK49_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK49_RS00465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETK49_RS00470	COG0512	Glutamine amidotransferase of anthranilate synthase
ETK49_RS00475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK49_RS00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ETK49_RS00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ETK49_RS00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ETK49_RS00495	COG1396	sequence-specific DNA binding
ETK49_RS00500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ETK49_RS00505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ETK49_RS00585	COG4463	regulation of RNA biosynthetic process
ETK49_RS00590	COG3880	PFAM UvrB UvrC protein
ETK49_RS00595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ETK49_RS00600	COG0542	response to heat
ETK49_RS00605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ETK49_RS00610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ETK49_RS00615	COG4956	integral membrane protein (PIN domain superfamily)
ETK49_RS00620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ETK49_RS00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ETK49_RS00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ETK49_RS00635	COG1045	serine acetyltransferase
ETK49_RS00640	COG0215	cysteine-tRNA ligase activity
ETK49_RS00645	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ETK49_RS00650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETK49_RS00655	COG3688	RNA-binding protein containing a PIN domain
ETK49_RS00665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ETK49_RS00675	COG0250	Participates in transcription elongation, termination and antitermination
ETK49_RS00680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ETK49_RS00685	COG0081	regulation of translation
ETK49_RS00690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ETK49_RS00695	COG0222	ribosome binding
ETK49_RS00700	COG2813	Specifically methylates the guanine in position
ETK49_RS00705	COG0085	RNA polymerase activity
ETK49_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ETK49_RS00715	COG1358	cellular component organization or biogenesis
ETK49_RS00720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ETK49_RS00725	COG0049	tRNA binding
ETK49_RS00730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ETK49_RS00735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ETK49_RS00745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ETK49_RS00750	COG0088	Forms part of the polypeptide exit tunnel
ETK49_RS00755	COG0089	rRNA binding
ETK49_RS00760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ETK49_RS00765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ETK49_RS00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ETK49_RS00775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ETK49_RS00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ETK49_RS00785	COG0255	Belongs to the universal ribosomal protein uL29 family
ETK49_RS00790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ETK49_RS00795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ETK49_RS00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ETK49_RS00805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ETK49_RS00810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ETK49_RS00815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ETK49_RS00820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ETK49_RS00825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ETK49_RS00830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ETK49_RS00835	COG1841	ribosomal large subunit assembly
ETK49_RS00840	COG0200	Binds to the 23S rRNA
ETK49_RS00845	COG0201	protein transport
ETK49_RS00850	COG0563	adenylate kinase activity
ETK49_RS00855	COG0024	Methionine aminopeptidase
ETK49_RS00860	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ETK49_RS00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ETK49_RS00870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ETK49_RS00875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ETK49_RS00880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ETK49_RS00885	COG0202	RNA polymerase activity
ETK49_RS00890	COG0203	ribosomal protein L17
ETK49_RS00895	COG1122	ATPase activity
ETK49_RS00900	COG1122	ATPase activity
ETK49_RS00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ETK49_RS00910	COG0101	tRNA pseudouridine synthase activity
ETK49_RS00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ETK49_RS00920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ETK49_RS00925	COG2318	DinB family
ETK49_RS00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS00940	COG0489	protein tyrosine kinase activity
ETK49_RS00950	COG2194	sulfuric ester hydrolase activity
ETK49_RS00955	COG0726	polysaccharide deacetylase
ETK49_RS00985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK49_RS00995	COG0385	Bile acid
ETK49_RS01010	COG3876	Protein conserved in bacteria
ETK49_RS01015	COG1472	Belongs to the glycosyl hydrolase 3 family
ETK49_RS01020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK49_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS01025	COG1263	PTS System
ETK49_RS01030	COG1737	Transcriptional regulator
ETK49_RS01035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ETK49_RS01040	COG1683	Conserved Protein
ETK49_RS01075	COG1595	DNA-templated transcription, initiation
ETK49_RS01080	COG5662	AntiSigma factor
ETK49_RS01085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ETK49_RS01090	COG4856	YbbR-like protein
ETK49_RS01095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETK49_RS01100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ETK49_RS01120	COG1725	Transcriptional regulator
ETK49_RS01125	COG0640	Transcriptional regulator
ETK49_RS01130	COG2814	Major facilitator Superfamily
ETK49_RS01140	COG1132	(ABC) transporter
ETK49_RS01145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ETK49_RS01170	COG1011	Hydrolase
ETK49_RS01175	COG1113	amino acid transport
ETK49_RS01180	COG2851	Citrate transporter
ETK49_RS01185	COG3181	Tripartite tricarboxylate transporter family receptor
ETK49_RS01190	COG4565	transcriptional regulatory protein
ETK49_RS01195	COG3290	protein histidine kinase activity
ETK49_RS01210	COG2211	Major facilitator Superfamily
ETK49_RS01230	COG1331	Highly conserved protein containing a thioredoxin domain
ETK49_RS01240	COG0477	Major facilitator Superfamily
ETK49_RS01260	COG1283	sodium-dependent phosphate transmembrane transporter activity
ETK49_RS01265	COG4682	membrane
ETK49_RS01290	COG0697	spore germination
ETK49_RS01295	COG2207	Transcriptional regulator
ETK49_RS01295	COG1917	Cupin 2, conserved barrel domain protein
ETK49_RS01315	COG0371	Dehydrogenase
ETK49_RS01320	COG0840	transmembrane signaling receptor activity
ETK49_RS01325	COG4213	ABC transporter substrate-binding protein
ETK49_RS01340	COG4257	antibiotic catabolic process
ETK49_RS01350	COG0833	amino acid
ETK49_RS01355	COG2040	homocysteine
ETK49_RS01365	COG2190	(PTS) system
ETK49_RS01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS01365	COG1263	PTS System
ETK49_RS01370	COG0789	Transcriptional regulator
ETK49_RS01375	COG2323	membrane
ETK49_RS01380	COG4451	ribulose bisphosphate carboxylase, small
ETK49_RS01380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ETK49_RS01390	COG2205	protein histidine kinase activity
ETK49_RS01395	COG1115	amino acid carrier protein
ETK49_RS01400	COG2066	Belongs to the glutaminase family
ETK49_RS01405	COG4191	Histidine kinase
ETK49_RS01410	COG0784	Response regulator, receiver
ETK49_RS01435	COG3540	Alkaline phosphatase
ETK49_RS01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETK49_RS01445	COG0805	protein transport
ETK49_RS01450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETK49_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS01460	COG2271	Major facilitator Superfamily
ETK49_RS01465	COG4948	Mandelate Racemase Muconate Lactonizing
ETK49_RS01470	COG2186	Transcriptional regulator
ETK49_RS01475	COG2721	sulfolactate sulfo-lyase activity
ETK49_RS01485	COG2205	protein histidine kinase activity
ETK49_RS01490	COG1131	(ABC) transporter
ETK49_RS01515	COG3173	Aminoglycoside phosphotransferase
ETK49_RS01520	COG1846	Transcriptional regulator
ETK49_RS01525	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS01545	COG0789	Transcriptional regulator
ETK49_RS01570	COG0697	spore germination
ETK49_RS01575	COG1714	RDD family
ETK49_RS01580	COG3012	SEC-C Motif Domain Protein
ETK49_RS01580	COG1405	negative regulation of cell septum assembly
ETK49_RS01585	COG1131	(ABC) transporter
ETK49_RS01610	COG0583	DNA-binding transcription factor activity
ETK49_RS01615	COG1942	4-Oxalocrotonate Tautomerase
ETK49_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS01635	COG1288	antiporter activity
ETK49_RS01645	COG0456	acetyltransferase
ETK49_RS01655	COG1164	Oligoendopeptidase f
ETK49_RS01660	COG2261	transglycosylase associated protein
ETK49_RS01670	COG0247	lactate metabolic process
ETK49_RS01675	COG0277	FAD linked oxidase domain protein
ETK49_RS01680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS01685	COG1447	Phosphotransferase system cellobiose-specific component IIA
ETK49_RS01690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS01695	COG1486	melibiose metabolic process
ETK49_RS01700	COG2188	Transcriptional regulator
ETK49_RS01705	COG3394	polysaccharide catabolic process
ETK49_RS01720	COG3591	Belongs to the peptidase S1B family
ETK49_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS01735	COG1595	DNA-templated transcription, initiation
ETK49_RS01745	COG3773	Cell wall hydrolase
ETK49_RS01750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK49_RS01755	COG0791	NLP P60 protein
ETK49_RS01755	COG3883	PFAM NLP P60 protein
ETK49_RS01765	COG1131	(ABC) transporter
ETK49_RS01770	COG1309	transcriptional regulator
ETK49_RS01790	COG2310	stress, protein
ETK49_RS01795	COG2310	stress, protein
ETK49_RS01800	COG2310	stress, protein
ETK49_RS01805	COG0861	Integral membrane protein TerC family
ETK49_RS01825	COG3853	Toxic anion resistance protein (TelA)
ETK49_RS01830	COG0785	Cytochrome C biogenesis protein
ETK49_RS01840	COG0789	Transcriptional regulator
ETK49_RS01845	COG2223	nitrite transmembrane transporter activity
ETK49_RS01850	COG0039	L-malate dehydrogenase activity
ETK49_RS01855	COG1620	l-lactate permease
ETK49_RS01860	COG1280	lysine exporter protein (LysE YggA)
ETK49_RS01865	COG1113	amino acid transport
ETK49_RS01870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ETK49_RS01875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ETK49_RS01880	COG3541	Predicted nucleotidyltransferase
ETK49_RS01885	COG0506	proline dehydrogenase activity
ETK49_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS01895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS01900	COG2508	Transcriptional regulator
ETK49_RS01905	COG3689	TIGRFAM TIGR03943 family protein
ETK49_RS01910	COG0701	Predicted permease
ETK49_RS01915	COG3458	cephalosporin-C deacetylase activity
ETK49_RS01935	COG0765	amino acid transport
ETK49_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK49_RS01945	COG2249	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS01955	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS01965	COG3209	COG3209 Rhs family protein
ETK49_RS01975	COG3266	domain, Protein
ETK49_RS01975	COG0515	serine threonine protein kinase
ETK49_RS01980	COG0840	transmembrane signaling receptor activity
ETK49_RS01980	COG3290	protein histidine kinase activity
ETK49_RS01985	COG5444	nuclease activity
ETK49_RS02010	COG1176	ABC-type spermidine putrescine transport system, permease component I
ETK49_RS02015	COG1177	transmembrane transport
ETK49_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK49_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK49_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK49_RS02035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ETK49_RS02040	COG0697	spore germination
ETK49_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK49_RS02055	COG2819	hydrolase of the alpha beta superfamily
ETK49_RS02065	COG2364	Membrane
ETK49_RS02075	COG1131	(ABC) transporter
ETK49_RS02100	COG1126	abc transporter atp-binding protein
ETK49_RS02105	COG0765	amino acid transport
ETK49_RS02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK49_RS02115	COG3829	transcription factor binding
ETK49_RS02120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ETK49_RS02125	COG0833	amino acid
ETK49_RS02130	COG0010	Belongs to the arginase family
ETK49_RS02135	COG0583	DNA-binding transcription factor activity
ETK49_RS02140	COG0163	prenyltransferase activity
ETK49_RS02145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ETK49_RS02195	COG5444	nuclease activity
ETK49_RS02215	COG2972	Histidine kinase
ETK49_RS02220	COG4753	response regulator
ETK49_RS02220	COG2207	Transcriptional regulator
ETK49_RS02225	COG4213	ABC transporter substrate-binding protein
ETK49_RS02235	COG4214	carbohydrate transport
ETK49_RS02240	COG2271	Major facilitator Superfamily
ETK49_RS02245	COG0456	acetyltransferase
ETK49_RS02245	COG1846	Transcriptional regulator
ETK49_RS02250	COG1874	Beta-galactosidase
ETK49_RS02255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ETK49_RS02260	COG3104	oligopeptide transport
ETK49_RS02265	COG5434	Belongs to the glycosyl hydrolase 28 family
ETK49_RS02275	COG0697	spore germination
ETK49_RS02285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ETK49_RS02290	COG0789	Transcriptional regulator
ETK49_RS02295	COG1136	(ABC) transporter
ETK49_RS02300	COG0577	efflux transmembrane transporter activity
ETK49_RS02305	COG0745	RESPONSE REGULATOR receiver
ETK49_RS02310	COG3850	Histidine kinase
ETK49_RS02310	COG5002	protein histidine kinase activity
ETK49_RS02315	COG0840	transmembrane signaling receptor activity
ETK49_RS02320	COG0527	aspartate kinase activity
ETK49_RS02325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS02330	COG4605	iron ion homeostasis
ETK49_RS02335	COG4604	ABC transporter, ATP-binding protein
ETK49_RS02340	COG4607	ABC-type enterochelin transport system periplasmic component
ETK49_RS02345	COG2814	Major facilitator Superfamily
ETK49_RS02350	COG1309	transcriptional regulator
ETK49_RS02360	COG0778	Nitroreductase
ETK49_RS02365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ETK49_RS02370	COG0640	Transcriptional regulator
ETK49_RS02375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK49_RS02380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ETK49_RS02385	COG0531	amino acid
ETK49_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS02395	COG0697	spore germination
ETK49_RS02405	COG4549	nuclear export factor GLE1
ETK49_RS02410	COG2372	response to copper ion
ETK49_RS02410	COG1276	copper resistance
ETK49_RS02415	COG1349	DNA-binding transcription factor activity
ETK49_RS02420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK49_RS02425	COG0243	molybdopterin cofactor binding
ETK49_RS02430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK49_RS02435	COG2146	nitrite reductase [NAD(P)H] activity
ETK49_RS02440	COG1587	Uroporphyrinogen-III synthase
ETK49_RS02440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETK49_RS02445	COG1802	Transcriptional regulator
ETK49_RS02450	COG0471	metal ion transport
ETK49_RS02455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETK49_RS02460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETK49_RS02475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS02490	COG3959	Transketolase, thiamine diphosphate binding domain
ETK49_RS02495	COG3958	Transketolase
ETK49_RS02500	COG0561	phosphatase activity
ETK49_RS02505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ETK49_RS02510	COG1914	H( )-stimulated, divalent metal cation uptake system
ETK49_RS02515	COG4336	lyase activity
ETK49_RS02520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ETK49_RS02525	COG1984	allophanate hydrolase subunit 2
ETK49_RS02530	COG1414	Transcriptional regulator
ETK49_RS02535	COG2755	lipolytic protein G-D-S-L family
ETK49_RS02540	COG2213	PTS system mannitol-specific
ETK49_RS02545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS02550	COG0246	Mannitol dehydrogenase
ETK49_RS02555	COG3711	transcriptional antiterminator
ETK49_RS02560	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS02565	COG1917	Cupin 2, conserved barrel domain protein
ETK49_RS02575	COG3871	stress protein (general stress protein 26)
ETK49_RS02590	COG2814	Major facilitator Superfamily
ETK49_RS02600	COG1522	sequence-specific DNA binding
ETK49_RS02605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ETK49_RS02605	COG0551	DNA topoisomerase type I activity
ETK49_RS02610	COG0531	amino acid
ETK49_RS02615	COG0028	Belongs to the TPP enzyme family
ETK49_RS02620	COG3397	chitin binding
ETK49_RS02630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK49_RS02635	COG1914	H( )-stimulated, divalent metal cation uptake system
ETK49_RS02640	COG2261	transglycosylase associated protein
ETK49_RS02645	COG1027	Aspartate ammonia-lyase
ETK49_RS02650	COG1819	glycosyl
ETK49_RS02655	COG4876	unkown
ETK49_RS02660	COG2217	Heavy metal translocating P-type atpase
ETK49_RS02670	COG0662	Cupin 2, conserved barrel domain protein
ETK49_RS02675	COG3729	General stress protein
ETK49_RS02680	COG0628	permease
ETK49_RS02685	COG1301	dicarboxylic acid transport
ETK49_RS02690	COG1131	(ABC) transporter
ETK49_RS02695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK49_RS02705	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS02720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS02725	COG1181	Belongs to the D-alanine--D-alanine ligase family
ETK49_RS02730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ETK49_RS02740	COG0513	Belongs to the DEAD box helicase family
ETK49_RS02745	COG3402	PFAM membrane-flanked domain
ETK49_RS02750	COG3428	Bacterial PH domain
ETK49_RS02755	COG0705	Rhomboid family
ETK49_RS02760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ETK49_RS02765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ETK49_RS02770	COG0864	Transcriptional regulator
ETK49_RS02775	COG2337	Toxic component of a toxin-antitoxin (TA) module
ETK49_RS02780	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK49_RS02785	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK49_RS02790	COG2172	sigma factor antagonist activity
ETK49_RS02795	COG2208	phosphoserine phosphatase activity
ETK49_RS02805	COG2172	sigma factor antagonist activity
ETK49_RS02810	COG1191	sigma factor activity
ETK49_RS02815	COG2208	phosphoserine phosphatase activity
ETK49_RS02820	COG2183	response to ionizing radiation
ETK49_RS02825	COG1309	transcriptional regulator
ETK49_RS02830	COG1033	growth of symbiont in host cell
ETK49_RS02830	COG2409	Drug exporters of the RND superfamily
ETK49_RS02840	COG3091	SprT-like family
ETK49_RS02885	COG1476	TRANSCRIPTIONal
ETK49_RS02890	COG3239	Fatty acid desaturase
ETK49_RS02895	COG1278	Cold shock
ETK49_RS02910	COG2364	Membrane
ETK49_RS02915	COG1846	Transcriptional regulator
ETK49_RS02920	COG0456	acetyltransferase
ETK49_RS02925	COG2808	Putative FMN-binding domain
ETK49_RS02935	COG1733	regulation of RNA biosynthetic process
ETK49_RS02940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS02950	COG0583	DNA-binding transcription factor activity
ETK49_RS02965	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ETK49_RS02970	COG1113	amino acid transport
ETK49_RS02985	COG1595	DNA-templated transcription, initiation
ETK49_RS02995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ETK49_RS02995	COG2755	lipolytic protein G-D-S-L family
ETK49_RS03000	COG2814	Major facilitator Superfamily
ETK49_RS03010	COG3279	Response regulator of the LytR AlgR family
ETK49_RS03020	COG3764	Sortase (surface protein transpeptidase)
ETK49_RS03030	COG2814	Major facilitator Superfamily
ETK49_RS03070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ETK49_RS03075	COG0802	atpase or kinase
ETK49_RS03080	COG1214	PFAM Peptidase M22, glycoprotease
ETK49_RS03085	COG0456	acetyltransferase
ETK49_RS03090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ETK49_RS03095	COG0488	(ABC) transporter
ETK49_RS03100	COG0315	cyclic pyranopterin monophosphate synthase activity
ETK49_RS03105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ETK49_RS03110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETK49_RS03115	COG0805	protein transport
ETK49_RS03125	COG1266	CAAX protease self-immunity
ETK49_RS03130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ETK49_RS03135	COG0459	protein refolding
ETK49_RS03165	COG2720	vancomycin resistance protein
ETK49_RS03180	COG2135	peptidase activity
ETK49_RS03190	COG1309	transcriptional regulator
ETK49_RS03195	COG0574	Belongs to the PEP-utilizing enzyme family
ETK49_RS03195	COG3848	Pyruvate phosphate dikinase
ETK49_RS03205	COG3189	MarR family transcriptional regulator
ETK49_RS03210	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ETK49_RS03215	COG2272	Belongs to the type-B carboxylesterase lipase family
ETK49_RS03220	COG2814	Major facilitator Superfamily
ETK49_RS03225	COG1842	Phage shock protein A
ETK49_RS03230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ETK49_RS03235	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ETK49_RS03240	COG4260	virion core protein, lumpy skin disease virus
ETK49_RS03250	COG1378	Sugar-specific transcriptional regulator TrmB
ETK49_RS03255	COG1280	lysine exporter protein (LysE YggA)
ETK49_RS03260	COG3339	Conserved Protein
ETK49_RS03265	COG0772	Belongs to the SEDS family
ETK49_RS03270	COG0772	Belongs to the SEDS family
ETK49_RS03295	COG0726	polysaccharide deacetylase
ETK49_RS03305	COG1609	Transcriptional regulator
ETK49_RS03310	COG0366	Alpha amylase catalytic
ETK49_RS03315	COG2182	Extracellular solute-binding protein
ETK49_RS03320	COG1175	transmembrane transport
ETK49_RS03325	COG3833	ABC-type maltose transport systems, permease component
ETK49_RS03330	COG5521	maltodextrose utilization protein MalA
ETK49_RS03335	COG1554	hydrolase, family 65, central catalytic
ETK49_RS03340	COG0366	Alpha amylase catalytic
ETK49_RS03345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ETK49_RS03350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ETK49_RS03355	COG1846	Transcriptional regulator
ETK49_RS03370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ETK49_RS03375	COG0823	Involved in the tonB-independent uptake of proteins
ETK49_RS03405	COG0702	epimerase
ETK49_RS03430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ETK49_RS03435	COG0714	Associated with various cellular activities
ETK49_RS03440	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ETK49_RS03445	COG1305	Transglutaminase-like
ETK49_RS03450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ETK49_RS03450	COG0519	Catalyzes the synthesis of GMP from XMP
ETK49_RS03460	COG2252	PERMEase
ETK49_RS03475	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ETK49_RS03485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ETK49_RS03490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ETK49_RS03495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ETK49_RS03500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ETK49_RS03505	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETK49_RS03510	COG0047	phosphoribosylformylglycinamidine synthase activity
ETK49_RS03515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETK49_RS03520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ETK49_RS03525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ETK49_RS03530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ETK49_RS03535	COG0138	bifunctional purine biosynthesis protein purh
ETK49_RS03540	COG0151	Belongs to the GarS family
ETK49_RS03550	COG2124	cytochrome p450
ETK49_RS03570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ETK49_RS03575	COG1470	cell adhesion involved in biofilm formation
ETK49_RS03580	COG4496	protein, YerC YecD
ETK49_RS03585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ETK49_RS03590	COG0210	DNA helicase
ETK49_RS03595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ETK49_RS03600	COG4851	CamS sex pheromone cAM373 precursor
ETK49_RS03605	COG2188	Transcriptional regulator
ETK49_RS03625	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ETK49_RS03630	COG0626	cystathionine gamma-synthase activity
ETK49_RS03635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ETK49_RS03640	COG3457	Alanine racemase
ETK49_RS03645	COG0363	glucosamine-6-phosphate deaminase activity
ETK49_RS03650	COG1285	pathogenesis
ETK49_RS03655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS03660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETK49_RS03665	COG0154	amidase activity
ETK49_RS03670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETK49_RS03685	COG4124	Belongs to the glycosyl hydrolase 26 family
ETK49_RS03690	COG1309	transcriptional regulator
ETK49_RS03695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ETK49_RS03705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK49_RS03710	COG1957	nucleoside hydrolase
ETK49_RS03715	COG1597	lipid kinase activity
ETK49_RS03720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ETK49_RS03730	COG2190	(PTS) system
ETK49_RS03730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS03730	COG1263	PTS System
ETK49_RS03735	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS03740	COG3711	transcriptional antiterminator
ETK49_RS03745	COG0457	Tetratricopeptide repeat
ETK49_RS03765	COG0217	transcriptional regulatory protein
ETK49_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS03785	COG0840	transmembrane signaling receptor activity
ETK49_RS03790	COG0471	metal ion transport
ETK49_RS03795	COG0488	(ABC) transporter
ETK49_RS03805	COG1469	GTP cyclohydrolase I activity
ETK49_RS03820	COG0523	cobalamin synthesis protein
ETK49_RS03825	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ETK49_RS03830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK49_RS03835	COG0156	8-amino-7-oxononanoate synthase activity
ETK49_RS03840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ETK49_RS03845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ETK49_RS03850	COG2124	cytochrome p450
ETK49_RS03860	COG0789	Transcriptional regulator
ETK49_RS03865	COG2814	Major facilitator Superfamily
ETK49_RS03870	COG0488	(ABC) transporter
ETK49_RS03875	COG0513	Belongs to the DEAD box helicase family
ETK49_RS03880	COG2130	NADP-dependent
ETK49_RS03895	COG0471	metal ion transport
ETK49_RS03915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS03925	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ETK49_RS03930	COG5658	integral membrane protein
ETK49_RS03935	COG0640	Transcriptional regulator
ETK49_RS03940	COG1254	Belongs to the acylphosphatase family
ETK49_RS03945	COG2258	MOSC domain
ETK49_RS03955	COG0024	Methionine aminopeptidase
ETK49_RS03960	COG1368	sulfuric ester hydrolase activity
ETK49_RS03970	COG1115	amino acid carrier protein
ETK49_RS03975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS03975	COG1263	PTS System
ETK49_RS03980	COG0366	Alpha amylase catalytic
ETK49_RS03985	COG2188	Transcriptional regulator
ETK49_RS04010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK49_RS04015	COG1045	serine acetyltransferase
ETK49_RS04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK49_RS04030	COG1215	transferase activity, transferring glycosyl groups
ETK49_RS04035	COG0463	Glycosyl transferase, family 2
ETK49_RS04035	COG0457	Tetratricopeptide repeat
ETK49_RS04045	COG0673	inositol 2-dehydrogenase activity
ETK49_RS04055	COG0657	acetylesterase activity
ETK49_RS04060	COG1733	regulation of RNA biosynthetic process
ETK49_RS04065	COG0778	Nitroreductase
ETK49_RS04070	COG0737	Belongs to the 5'-nucleotidase family
ETK49_RS04075	COG0693	protein deglycase activity
ETK49_RS04080	COG4840	Belongs to the UPF0435 family
ETK49_RS04085	COG1115	amino acid carrier protein
ETK49_RS04090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK49_RS04095	COG4980	gas vesicle protein
ETK49_RS04100	COG1295	ribonuclease BN
ETK49_RS04105	COG0477	Major facilitator Superfamily
ETK49_RS04115	COG0387	Pfam Sodium calcium exchanger
ETK49_RS04125	COG0535	radical SAM domain protein
ETK49_RS04135	COG0726	polysaccharide deacetylase
ETK49_RS04140	COG0371	Dehydrogenase
ETK49_RS04150	COG0598	Magnesium transport protein CorA
ETK49_RS04155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ETK49_RS04160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ETK49_RS04165	COG4637	Psort location Cytoplasmic, score
ETK49_RS04190	COG1819	glycosyl
ETK49_RS04200	COG0477	Major facilitator Superfamily
ETK49_RS04205	COG1263	PTS System
ETK49_RS04205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS04210	COG3711	transcriptional antiterminator
ETK49_RS04215	COG0288	reversible hydration of carbon dioxide
ETK49_RS04220	COG3002	Belongs to the UPF0753 family
ETK49_RS04225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETK49_RS04230	COG5609	conserved protein (DUF2294)
ETK49_RS04240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK49_RS04245	COG0022	dehydrogenase e1 component
ETK49_RS04250	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK49_RS04255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK49_RS04260	COG3284	Transcriptional regulator
ETK49_RS04265	COG1742	UPF0060 membrane protein
ETK49_RS04270	COG1486	melibiose metabolic process
ETK49_RS04275	COG1737	Transcriptional regulator
ETK49_RS04280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS04280	COG1263	PTS System
ETK49_RS04295	COG1733	regulation of RNA biosynthetic process
ETK49_RS04300	COG2259	Doxx family
ETK49_RS04305	COG2514	catechol 2,3-dioxygenase activity
ETK49_RS04315	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK49_RS04320	COG2207	Transcriptional regulator
ETK49_RS04320	COG1917	Cupin 2, conserved barrel domain protein
ETK49_RS04325	COG1653	transport
ETK49_RS04330	COG2249	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS04335	COG1051	belongs to the nudix hydrolase family
ETK49_RS04345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ETK49_RS04345	COG0392	lysyltransferase activity
ETK49_RS04350	COG0384	phenazine biosynthesis protein PhzF
ETK49_RS04355	COG0778	Nitroreductase
ETK49_RS04375	COG1090	epimerase
ETK49_RS04380	COG2137	regulation of response to DNA damage stimulus
ETK49_RS04410	COG0463	Glycosyl transferase, family 2
ETK49_RS04420	COG4485	Bacterial membrane protein, YfhO
ETK49_RS04425	COG1988	membrane-bound metal-dependent
ETK49_RS04430	COG1194	a g-specific adenine glycosylase
ETK49_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS04455	COG3557	Belongs to the UPF0374 family
ETK49_RS04460	COG1132	(ABC) transporter
ETK49_RS04465	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS04470	COG4608	Belongs to the ABC transporter superfamily
ETK49_RS04475	COG0747	negative chemotaxis
ETK49_RS04480	COG0601	transmembrane transport
ETK49_RS04485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK49_RS04490	COG4129	membrane
ETK49_RS04495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETK49_RS04500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ETK49_RS04505	COG0735	belongs to the Fur family
ETK49_RS04610	COG4974	Belongs to the 'phage' integrase family
ETK49_RS04730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK49_RS04730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK49_RS04765	COG1780	Probably involved in ribonucleotide reductase function
ETK49_RS04770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK49_RS04780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK49_RS04785	COG0756	dUTP diphosphatase activity
ETK49_RS04800	COG3584	3D domain protein
ETK49_RS04885	COG0582	viral genome integration into host DNA
ETK49_RS05005	COG3409	Peptidoglycan-binding domain 1 protein
ETK49_RS05005	COG1388	LysM domain
ETK49_RS05005	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS05020	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS05045	COG0457	Tetratricopeptide repeat
ETK49_RS05090	COG5444	nuclease activity
ETK49_RS05095	COG0457	Tetratricopeptide repeat
ETK49_RS05100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ETK49_RS05110	COG0710	3-dehydroquinate dehydratase activity
ETK49_RS05115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ETK49_RS05120	COG1116	anion transmembrane transporter activity
ETK49_RS05125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ETK49_RS05130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ETK49_RS05135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK49_RS05155	COG1131	(ABC) transporter
ETK49_RS05175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ETK49_RS05185	COG3382	B3 4 domain protein
ETK49_RS05190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ETK49_RS05200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ETK49_RS05205	COG0789	Transcriptional regulator
ETK49_RS05210	COG1664	Polymer-forming cytoskeletal
ETK49_RS05220	COG2766	serine protein kinase
ETK49_RS05225	COG2718	Belongs to the UPF0229 family
ETK49_RS05235	COG1566	PFAM secretion protein HlyD family protein
ETK49_RS05240	COG2814	Major facilitator Superfamily
ETK49_RS05245	COG0655	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS05260	COG1131	(ABC) transporter
ETK49_RS05265	COG1131	(ABC) transporter
ETK49_RS05270	COG1131	(ABC) transporter
ETK49_RS05275	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK49_RS05280	COG1278	Cold shock
ETK49_RS05285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ETK49_RS05290	COG2011	ABC-type metal ion transport system permease component
ETK49_RS05295	COG1464	Belongs to the NlpA lipoprotein family
ETK49_RS05300	COG1823	symporter activity
ETK49_RS05325	COG5577	PFAM Coat F domain
ETK49_RS05330	COG5002	protein histidine kinase activity
ETK49_RS05335	COG0737	Belongs to the 5'-nucleotidase family
ETK49_RS05335	COG4085	toxin activity
ETK49_RS05335	COG1525	nuclease
ETK49_RS05340	COG3764	Sortase (surface protein transpeptidase)
ETK49_RS05345	COG0564	pseudouridine synthase activity
ETK49_RS05355	COG0517	IMP dehydrogenase activity
ETK49_RS05360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ETK49_RS05365	COG3153	acetyltransferase
ETK49_RS05365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ETK49_RS05370	COG0488	(ABC) transporter
ETK49_RS05380	COG2116	formate transmembrane transporter activity
ETK49_RS05385	COG0679	Auxin Efflux Carrier
ETK49_RS05390	COG0604	alcohol dehydrogenase
ETK49_RS05395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ETK49_RS05400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ETK49_RS05405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ETK49_RS05410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ETK49_RS05415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETK49_RS05430	COG4585	Histidine kinase
ETK49_RS05430	COG2203	Gaf domain
ETK49_RS05435	COG2197	response regulator
ETK49_RS05440	COG0431	NADPH-dependent FMN reductase
ETK49_RS05455	COG1959	2 iron, 2 sulfur cluster binding
ETK49_RS05460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ETK49_RS05460	COG1017	nitric oxide dioxygenase activity
ETK49_RS05465	COG2719	SpoVR family
ETK49_RS05470	COG0791	NLP P60 protein
ETK49_RS05470	COG1388	LysM domain
ETK49_RS05475	COG0583	DNA-binding transcription factor activity
ETK49_RS05480	COG0372	Belongs to the citrate synthase family
ETK49_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS05495	COG0733	neurotransmitter:sodium symporter activity
ETK49_RS05505	COG2207	Transcriptional regulator
ETK49_RS05505	COG3708	Transcriptional regulator
ETK49_RS05530	COG1595	DNA-templated transcription, initiation
ETK49_RS05535	COG0662	Cupin 2, conserved barrel domain protein
ETK49_RS05545	COG0204	Acyl-transferase
ETK49_RS05550	COG3152	Membrane
ETK49_RS05560	COG1309	transcriptional regulator
ETK49_RS05565	COG1253	flavin adenine dinucleotide binding
ETK49_RS05570	COG0789	Transcriptional regulator
ETK49_RS05575	COG1253	flavin adenine dinucleotide binding
ETK49_RS05595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ETK49_RS05600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ETK49_RS05605	COG0584	glycerophosphoryl diester phosphodiesterase
ETK49_RS05615	COG0668	transmembrane transport
ETK49_RS05620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ETK49_RS05630	COG0726	polysaccharide deacetylase
ETK49_RS05640	COG1757	Na H antiporter
ETK49_RS05645	COG2017	converts alpha-aldose to the beta-anomer
ETK49_RS05670	COG0589	response to stress
ETK49_RS05675	COG1132	(ABC) transporter
ETK49_RS05680	COG1132	(ABC) transporter
ETK49_RS05685	COG0702	epimerase
ETK49_RS05700	COG3842	ATPase activity
ETK49_RS05705	COG2508	Transcriptional regulator
ETK49_RS05715	COG0189	ligase activity
ETK49_RS05720	COG0189	ligase activity
ETK49_RS05725	COG4399	Belongs to the UPF0754 family
ETK49_RS05730	COG3679	Belongs to the UPF0342 family
ETK49_RS05740	COG0561	phosphatase activity
ETK49_RS05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETK49_RS05750	COG0475	glutathione-regulated potassium exporter activity
ETK49_RS05755	COG0490	domain, Protein
ETK49_RS05765	COG1024	Enoyl-CoA hydratase
ETK49_RS05770	COG0457	Tetratricopeptide repeat
ETK49_RS05785	COG4152	abc transporter atp-binding protein
ETK49_RS05790	COG1668	transmembrane transport
ETK49_RS05795	COG0420	3'-5' exonuclease activity
ETK49_RS05800	COG4717	serine-type aminopeptidase activity
ETK49_RS05805	COG3481	metal-dependent phosphohydrolase, HD sub domain
ETK49_RS05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETK49_RS05845	COG1846	Transcriptional regulator
ETK49_RS05850	COG4980	gas vesicle protein
ETK49_RS05865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ETK49_RS05870	COG0537	adenosine 5'-monophosphoramidase activity
ETK49_RS05880	COG1131	(ABC) transporter
ETK49_RS05885	COG4473	ABC transporter
ETK49_RS05895	COG1473	amidohydrolase
ETK49_RS05900	COG3069	C4-dicarboxylate transmembrane transporter activity
ETK49_RS05905	COG2329	Antibiotic biosynthesis monooxygenase
ETK49_RS05910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK49_RS05915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ETK49_RS05920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ETK49_RS05925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ETK49_RS05930	COG1309	transcriptional regulator
ETK49_RS05935	COG1511	domain protein
ETK49_RS05940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK49_RS05945	COG1363	Peptidase, m42
ETK49_RS05955	COG1301	dicarboxylic acid transport
ETK49_RS05965	COG1234	tRNA 3'-trailer cleavage
ETK49_RS05970	COG0095	Lipoate-protein ligase
ETK49_RS05975	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS05985	COG1396	sequence-specific DNA binding
ETK49_RS06000	COG0501	Belongs to the peptidase M48B family
ETK49_RS06010	COG0697	spore germination
ETK49_RS06015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ETK49_RS06020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS06025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS06030	COG0406	alpha-ribazole phosphatase activity
ETK49_RS06035	COG0840	transmembrane signaling receptor activity
ETK49_RS06040	COG0723	plastoquinol--plastocyanin reductase activity
ETK49_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ETK49_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS06055	COG4903	ComK protein
ETK49_RS06065	COG0398	Pfam SNARE associated Golgi protein
ETK49_RS06070	COG0681	Belongs to the peptidase S26 family
ETK49_RS06075	COG1404	Belongs to the peptidase S8 family
ETK49_RS06085	COG2508	Transcriptional regulator
ETK49_RS06095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ETK49_RS06100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK49_RS06105	COG3257	ureidoglycine aminohydrolase activity
ETK49_RS06110	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ETK49_RS06115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ETK49_RS06120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ETK49_RS06125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ETK49_RS06135	COG0549	Belongs to the carbamate kinase family
ETK49_RS06140	COG2814	Major facilitator Superfamily
ETK49_RS06150	COG0457	Tetratricopeptide repeat
ETK49_RS06170	COG1609	Transcriptional regulator
ETK49_RS06175	COG1653	transport
ETK49_RS06180	COG1175	transmembrane transport
ETK49_RS06185	COG0395	ABC-type sugar transport system, permease component
ETK49_RS06190	COG1486	melibiose metabolic process
ETK49_RS06195	COG3180	Ammonia monooxygenase
ETK49_RS06210	COG3546	catalase activity
ETK49_RS06215	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS06220	COG2814	Major facilitator Superfamily
ETK49_RS06220	COG0477	Major facilitator Superfamily
ETK49_RS06230	COG5002	protein histidine kinase activity
ETK49_RS06235	COG0745	RESPONSE REGULATOR receiver
ETK49_RS06240	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ETK49_RS06245	COG0725	ABC transporter, periplasmic molybdate-binding protein
ETK49_RS06250	COG4149	molybdate abc transporter
ETK49_RS06255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ETK49_RS06260	COG1074	ATP-dependent DNA helicase activity
ETK49_RS06265	COG0420	3'-5' exonuclease activity
ETK49_RS06270	COG0419	ATPase involved in DNA repair
ETK49_RS06315	COG5337	Spore coat protein CotH
ETK49_RS06325	COG0179	Fumarylacetoacetate (FAA) hydrolase
ETK49_RS06345	COG0367	asparagine synthase
ETK49_RS06350	COG0004	ammonium transporteR
ETK49_RS06355	COG0347	Belongs to the P(II) protein family
ETK49_RS06360	COG0534	Mate efflux family protein
ETK49_RS06365	COG1917	Cupin 2, conserved barrel domain protein
ETK49_RS06365	COG2207	Transcriptional regulator
ETK49_RS06375	COG1609	Transcriptional regulator
ETK49_RS06400	COG1279	arginine transmembrane transporter activity
ETK49_RS06405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK49_RS06415	COG0076	glutamate decarboxylase activity
ETK49_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS06450	COG2378	regulation of single-species biofilm formation
ETK49_RS06455	COG0646	methionine synthase
ETK49_RS06455	COG1410	methionine synthase
ETK49_RS06460	COG0646	methionine synthase
ETK49_RS06460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ETK49_RS06465	COG1666	GTP binding
ETK49_RS06470	COG2996	Protein conserved in bacteria
ETK49_RS06485	COG1307	EDD domain protein, DegV family
ETK49_RS06490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS06500	COG0516	GMP reductase activity
ETK49_RS06510	COG0561	phosphatase activity
ETK49_RS06515	COG1073	alpha beta
ETK49_RS06520	COG2151	metal-sulfur cluster biosynthetic enzyme
ETK49_RS06530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ETK49_RS06535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ETK49_RS06540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ETK49_RS06545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ETK49_RS06550	COG0505	Belongs to the CarA family
ETK49_RS06555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ETK49_RS06560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ETK49_RS06565	COG1968	undecaprenyl-diphosphatase activity
ETK49_RS06580	COG2267	carboxylic ester hydrolase activity
ETK49_RS06590	COG1744	ABC transporter substrate-binding protein PnrA-like
ETK49_RS06605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK49_RS06610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ETK49_RS06620	COG5504	Zn-dependent protease
ETK49_RS06625	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS06630	COG4608	Belongs to the ABC transporter superfamily
ETK49_RS06640	COG0601	transmembrane transport
ETK49_RS06645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK49_RS06660	COG0180	Tryptophanyl-tRNA synthetase
ETK49_RS06675	COG0601	transmembrane transport
ETK49_RS06680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK49_RS06685	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS06690	COG4608	Belongs to the ABC transporter superfamily
ETK49_RS06695	COG0456	acetyltransferase
ETK49_RS06700	COG1393	Belongs to the ArsC family
ETK49_RS06705	COG0861	Integral membrane protein TerC family
ETK49_RS06715	COG4862	establishment of competence for transformation
ETK49_RS06735	COG4565	transcriptional regulatory protein
ETK49_RS06740	COG3290	protein histidine kinase activity
ETK49_RS06745	COG4469	Competence protein
ETK49_RS06750	COG1164	Oligoendopeptidase f
ETK49_RS06755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ETK49_RS06760	COG2346	COG2346, Truncated hemoglobins
ETK49_RS06765	COG0741	lytic transglycosylase activity
ETK49_RS06770	COG4116	CYTH
ETK49_RS06780	COG2357	RelA SpoT domain protein
ETK49_RS06785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ETK49_RS06790	COG0564	pseudouridine synthase activity
ETK49_RS06795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ETK49_RS06805	COG0475	glutathione-regulated potassium exporter activity
ETK49_RS06805	COG0569	domain protein
ETK49_RS06810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ETK49_RS06815	COG0352	thiamine-phosphate diphosphorylase activity
ETK49_RS06825	COG2104	thiamine diphosphate biosynthetic process
ETK49_RS06830	COG2022	thiamine diphosphate biosynthetic process
ETK49_RS06835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ETK49_RS06840	COG0351	phosphomethylpyrimidine kinase
ETK49_RS06845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ETK49_RS06900	COG0210	DNA helicase
ETK49_RS06910	COG0586	Pfam SNARE associated Golgi protein
ETK49_RS06915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETK49_RS06920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ETK49_RS06925	COG2246	polysaccharide biosynthetic process
ETK49_RS06930	COG2153	protein acetylation
ETK49_RS06935	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ETK49_RS06940	COG2382	esterase
ETK49_RS06960	COG0626	cystathionine gamma-synthase activity
ETK49_RS06965	COG0626	cystathionine gamma-synthase activity
ETK49_RS06970	COG5505	Protein of unknown function (DUF819)
ETK49_RS06990	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK49_RS07010	COG0110	maltose O-acetyltransferase activity
ETK49_RS07020	COG0583	DNA-binding transcription factor activity
ETK49_RS07025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ETK49_RS07030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK49_RS07035	COG0583	DNA-binding transcription factor activity
ETK49_RS07040	COG0697	spore germination
ETK49_RS07045	COG0346	lactoylglutathione lyase activity
ETK49_RS07055	COG3584	3D domain protein
ETK49_RS07055	COG1388	LysM domain
ETK49_RS07060	COG2814	Major facilitator Superfamily
ETK49_RS07065	COG1309	transcriptional regulator
ETK49_RS07085	COG5444	nuclease activity
ETK49_RS07090	COG4195	phage-related replication protein
ETK49_RS07095	COG2856	Zn peptidase
ETK49_RS07100	COG1396	sequence-specific DNA binding
ETK49_RS07115	COG1522	sequence-specific DNA binding
ETK49_RS07120	COG1484	DNA-dependent DNA replication
ETK49_RS07135	COG1595	DNA-templated transcription, initiation
ETK49_RS07140	COG5484	DNA packaging
ETK49_RS07140	COG3728	DNA packaging
ETK49_RS07145	COG1783	phage Terminase large subunit
ETK49_RS07150	COG5518	Phage portal protein
ETK49_RS07155	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ETK49_RS07160	COG4653	Phage capsid family
ETK49_RS07210	COG3953	SLT domain
ETK49_RS07210	COG5412	phage tail tape measure protein
ETK49_RS07215	COG1652	LysM domain
ETK49_RS07220	COG4193	domain, Protein
ETK49_RS07230	COG3628	GPW Gp25 family protein
ETK49_RS07235	COG3299	homolog of phage Mu protein gp47
ETK49_RS07240	COG3778	Protein conserved in bacteria
ETK49_RS07275	COG1802	Transcriptional regulator
ETK49_RS07280	COG1063	alcohol dehydrogenase
ETK49_RS07285	COG1312	Catalyzes the dehydration of D-mannonate
ETK49_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS07295	COG1063	alcohol dehydrogenase
ETK49_RS07315	COG0306	phosphate transporter
ETK49_RS07320	COG1392	Phosphate transport regulator
ETK49_RS07325	COG0405	Gamma-glutamyltransferase
ETK49_RS07330	COG5578	integral membrane protein
ETK49_RS07335	COG2972	Histidine kinase
ETK49_RS07340	COG2207	Transcriptional regulator
ETK49_RS07340	COG4753	response regulator
ETK49_RS07345	COG1653	transport
ETK49_RS07350	COG1175	transmembrane transport
ETK49_RS07355	COG0395	ABC-type sugar transport system, permease component
ETK49_RS07360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ETK49_RS07365	COG2207	Transcriptional regulator
ETK49_RS07370	COG2755	lipolytic protein G-D-S-L family
ETK49_RS07380	COG5578	integral membrane protein
ETK49_RS07385	COG3401	FG-GAP repeat protein
ETK49_RS07395	COG2755	lipolytic protein G-D-S-L family
ETK49_RS07400	COG3401	FG-GAP repeat protein
ETK49_RS07405	COG0667	Aldo Keto reductase
ETK49_RS07410	COG2755	lipolytic protein G-D-S-L family
ETK49_RS07415	COG1874	Beta-galactosidase
ETK49_RS07425	COG1653	transport
ETK49_RS07430	COG4209	transmembrane transport
ETK49_RS07435	COG0395	ABC-type sugar transport system, permease component
ETK49_RS07440	COG0531	amino acid
ETK49_RS07445	COG0346	lactoylglutathione lyase activity
ETK49_RS07455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK49_RS07460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK49_RS07465	COG2362	D-Aminopeptidase
ETK49_RS07470	COG0601	transmembrane transport
ETK49_RS07475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK49_RS07480	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS07485	COG4166	transmembrane transport
ETK49_RS07490	COG1619	proteins homologs of microcin C7 resistance protein MccF
ETK49_RS07495	COG4948	Mandelate Racemase Muconate Lactonizing
ETK49_RS07500	COG0791	NLP P60 protein
ETK49_RS07505	COG4608	Belongs to the ABC transporter superfamily
ETK49_RS07510	COG1834	amidinotransferase
ETK49_RS07515	COG1607	acyl-coa hydrolase
ETK49_RS07525	COG3866	Pectate lyase
ETK49_RS07545	COG2318	DinB family
ETK49_RS07550	COG2076	Multidrug Resistance protein
ETK49_RS07555	COG2076	Multidrug Resistance protein
ETK49_RS07560	COG0788	formyltetrahydrofolate deformylase activity
ETK49_RS07565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ETK49_RS07570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ETK49_RS07575	COG1764	response to oxidative stress
ETK49_RS07580	COG1846	Transcriptional regulator
ETK49_RS07585	COG1764	response to oxidative stress
ETK49_RS07595	COG0590	tRNA wobble adenosine to inosine editing
ETK49_RS07600	COG0406	alpha-ribazole phosphatase activity
ETK49_RS07615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETK49_RS07620	COG1404	Belongs to the peptidase S8 family
ETK49_RS07630	COG2239	Acts as a magnesium transporter
ETK49_RS07640	COG0582	viral genome integration into host DNA
ETK49_RS07670	COG3620	sequence-specific DNA binding
ETK49_RS07715	COG5377	YqaJ viral recombinase family
ETK49_RS07720	COG3723	Recombinational DNA repair protein, rece pathway
ETK49_RS07725	COG3935	DnaD domain protein
ETK49_RS07730	COG1484	DNA-dependent DNA replication
ETK49_RS07765	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ETK49_RS07780	COG0629	single-stranded DNA binding
ETK49_RS07805	COG3677	Transposase
ETK49_RS07815	COG5484	DNA packaging
ETK49_RS07820	COG1783	phage Terminase large subunit
ETK49_RS07940	COG0662	Cupin 2, conserved barrel domain protein
ETK49_RS07945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ETK49_RS07950	COG2323	membrane
ETK49_RS07955	COG0789	Transcriptional regulator
ETK49_RS07970	COG1846	Transcriptional regulator
ETK49_RS07975	COG1793	dna ligase
ETK49_RS07975	COG3285	dna ligase
ETK49_RS07980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ETK49_RS07985	COG3300	MHYT domain
ETK49_RS07985	COG5001	Diguanylate cyclase
ETK49_RS07990	COG0586	Pfam SNARE associated Golgi protein
ETK49_RS07995	COG0861	Integral membrane protein TerC family
ETK49_RS08000	COG1191	sigma factor activity
ETK49_RS08020	COG0501	Belongs to the peptidase M48B family
ETK49_RS08025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETK49_RS08030	COG0768	penicillin binding
ETK49_RS08045	COG3594	Acyltransferase
ETK49_RS08050	COG5002	protein histidine kinase activity
ETK49_RS08055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ETK49_RS08060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ETK49_RS08065	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ETK49_RS08070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ETK49_RS08075	COG0436	Aminotransferase
ETK49_RS08080	COG1850	ribulose-bisphosphate carboxylase activity
ETK49_RS08085	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ETK49_RS08085	COG0235	Class ii aldolase
ETK49_RS08090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ETK49_RS08095	COG0346	lactoylglutathione lyase activity
ETK49_RS08100	COG3339	Conserved Protein
ETK49_RS08110	COG3852	Histidine kinase
ETK49_RS08115	COG1846	Transcriptional regulator
ETK49_RS08120	COG1360	Flagellar Motor Protein
ETK49_RS08125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ETK49_RS08130	COG0542	response to heat
ETK49_RS08135	COG3949	Membrane
ETK49_RS08140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ETK49_RS08145	COG0720	synthase
ETK49_RS08150	COG0602	queuosine metabolic process
ETK49_RS08155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ETK49_RS08165	COG3739	integral membrane protein
ETK49_RS08170	COG3655	Transcriptional regulator
ETK49_RS08200	COG4873	Protein conserved in bacteria
ETK49_RS08210	COG3773	Cell wall hydrolase
ETK49_RS08215	COG2244	polysaccharide biosynthetic process
ETK49_RS08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS08225	COG2217	Heavy metal translocating P-type atpase
ETK49_RS08230	COG0006	proline dipeptidase activity
ETK49_RS08240	COG1609	Transcriptional regulator
ETK49_RS08245	COG3711	transcriptional antiterminator
ETK49_RS08250	COG1263	PTS System
ETK49_RS08250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS08250	COG2190	(PTS) system
ETK49_RS08255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS08260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ETK49_RS08270	COG1533	DNA photolyase activity
ETK49_RS08275	COG0456	acetyltransferase
ETK49_RS08280	COG0840	transmembrane signaling receptor activity
ETK49_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS08290	COG2084	Dehydrogenase
ETK49_RS08295	COG2340	Cysteine-rich secretory protein family
ETK49_RS08300	COG0768	penicillin binding
ETK49_RS08305	COG4191	Histidine kinase
ETK49_RS08310	COG0436	Aminotransferase
ETK49_RS08315	COG1714	RDD family
ETK49_RS08325	COG0835	chemotaxis
ETK49_RS08325	COG0784	Response regulator, receiver
ETK49_RS08335	COG2814	Major facilitator Superfamily
ETK49_RS08340	COG1376	ErfK ybiS ycfS ynhG family protein
ETK49_RS08350	COG1408	metallophosphoesterase
ETK49_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS08360	COG2200	EAL domain
ETK49_RS08370	COG4703	Protein of unknown function (DUF1797)
ETK49_RS08375	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ETK49_RS08385	COG0517	IMP dehydrogenase activity
ETK49_RS08390	COG0583	DNA-binding transcription factor activity
ETK49_RS08395	COG0716	FMN binding
ETK49_RS08405	COG0716	FMN binding
ETK49_RS08410	COG2171	N-acyltransferase activity
ETK49_RS08415	COG1473	amidohydrolase
ETK49_RS08425	COG0450	alkyl hydroperoxide reductase
ETK49_RS08430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS08445	COG0746	molybdenum cofactor guanylyltransferase activity
ETK49_RS08450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ETK49_RS08455	COG0303	'Molybdopterin
ETK49_RS08460	COG1763	Mo-molybdopterin cofactor biosynthetic process
ETK49_RS08465	COG0314	molybdopterin synthase activity
ETK49_RS08470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ETK49_RS08480	COG1132	(ABC) transporter
ETK49_RS08485	COG1132	(ABC) transporter
ETK49_RS08495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ETK49_RS08500	COG1136	(ABC) transporter
ETK49_RS08505	COG0577	efflux transmembrane transporter activity
ETK49_RS08510	COG1349	DNA-binding transcription factor activity
ETK49_RS08515	COG1105	Belongs to the carbohydrate kinase PfkB family
ETK49_RS08520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS08520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS08520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS08540	COG0488	(ABC) transporter
ETK49_RS08550	COG2309	aminopeptidase activity
ETK49_RS08560	COG1077	Cell shape determining protein MreB Mrl
ETK49_RS08565	COG2002	toxin-antitoxin pair type II binding
ETK49_RS08570	COG3852	Histidine kinase
ETK49_RS08575	COG0569	domain protein
ETK49_RS08580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ETK49_RS08585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ETK49_RS08590	COG5503	Protein of unknown function (DUF1447)
ETK49_RS08595	COG0561	phosphatase activity
ETK49_RS08600	COG0242	peptide deformylase activity
ETK49_RS08610	COG0497	DNA recombination
ETK49_RS08615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK49_RS08620	COG0022	dehydrogenase e1 component
ETK49_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK49_RS08630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK49_RS08635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS08645	COG1982	Orn Lys Arg decarboxylase major
ETK49_RS08655	COG4476	Belongs to the UPF0223 family
ETK49_RS08660	COG4493	Belongs to the UPF0637 family
ETK49_RS08670	COG0483	inositol monophosphate 1-phosphatase activity
ETK49_RS08690	COG1595	DNA-templated transcription, initiation
ETK49_RS08705	COG1217	gtp-binding protein TYPA
ETK49_RS08715	COG1846	Transcriptional regulator
ETK49_RS08720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ETK49_RS08725	COG4896	Protein conserved in bacteria
ETK49_RS08735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ETK49_RS08740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ETK49_RS08745	COG2066	Belongs to the glutaminase family
ETK49_RS08750	COG4838	Belongs to the UPF0358 family
ETK49_RS08755	COG0772	Belongs to the SEDS family
ETK49_RS08760	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ETK49_RS08765	COG1612	heme a metabolic process
ETK49_RS08770	COG0109	protoheme IX farnesyltransferase activity
ETK49_RS08775	COG2010	Cytochrome c
ETK49_RS08775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ETK49_RS08780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ETK49_RS08785	COG1845	cytochrome c oxidase, subunit III
ETK49_RS08790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ETK49_RS08795	COG3336	cytochrome c oxidase
ETK49_RS08805	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ETK49_RS08810	COG2340	Cysteine-rich secretory protein family
ETK49_RS08825	COG3679	Belongs to the UPF0342 family
ETK49_RS08830	COG4471	UPF0298 protein
ETK49_RS08835	COG0742	ribosomal rna small subunit methyltransferase
ETK49_RS08840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ETK49_RS08845	COG3314	Sporulation integral membrane protein YlbJ
ETK49_RS08850	COG3480	Lon protease (S16) C-terminal proteolytic domain
ETK49_RS08855	COG1323	Belongs to the UPF0348 family
ETK49_RS08860	COG1399	metal-binding, possibly nucleic acid-binding protein
ETK49_RS08865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ETK49_RS08875	COG0454	-acetyltransferase
ETK49_RS08880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ETK49_RS08885	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ETK49_RS08890	COG2001	Belongs to the MraZ family
ETK49_RS08895	COG0275	rRNA processing
ETK49_RS08900	COG4839	cell division protein FtsL
ETK49_RS08905	COG0768	penicillin binding
ETK49_RS08910	COG0768	penicillin binding
ETK49_RS08915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ETK49_RS08920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ETK49_RS08925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ETK49_RS08930	COG0772	Belongs to the SEDS family
ETK49_RS08935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK49_RS08940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ETK49_RS08945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ETK49_RS08950	COG3879	Bacterial protein of unknown function (DUF881)
ETK49_RS08955	COG3879	Bacterial protein of unknown function (DUF881)
ETK49_RS08960	COG3856	small basic protein
ETK49_RS08965	COG0849	cell division
ETK49_RS08970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ETK49_RS08980	COG1404	Belongs to the peptidase S8 family
ETK49_RS08980	COG4412	M6 family metalloprotease domain protein
ETK49_RS08985	COG1404	Belongs to the peptidase S8 family
ETK49_RS08985	COG4412	M6 family metalloprotease domain protein
ETK49_RS08995	COG1191	sigma factor activity
ETK49_RS09000	COG1191	sigma factor activity
ETK49_RS09005	COG1119	ATPase activity
ETK49_RS09010	COG0500	methyltransferase
ETK49_RS09015	COG1873	PFAM PRC-barrel domain
ETK49_RS09020	COG1496	oxidoreductase activity
ETK49_RS09025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ETK49_RS09030	COG1799	cell septum assembly
ETK49_RS09035	COG0762	integral membrane protein
ETK49_RS09040	COG2302	S4 RNA-binding domain
ETK49_RS09045	COG3599	regulation of cell shape
ETK49_RS09050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ETK49_RS09055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK49_RS09060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ETK49_RS09065	COG0564	pseudouridine synthase activity
ETK49_RS09070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ETK49_RS09075	COG2233	PERMEase
ETK49_RS09080	COG0540	Belongs to the ATCase OTCase family
ETK49_RS09085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ETK49_RS09090	COG0505	Belongs to the CarA family
ETK49_RS09095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ETK49_RS09100	COG0543	2 iron, 2 sulfur cluster binding
ETK49_RS09105	COG0167	dihydroorotate dehydrogenase activity
ETK49_RS09110	COG0284	orotidine-5'-phosphate decarboxylase activity
ETK49_RS09115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ETK49_RS09125	COG0175	sulfate reduction
ETK49_RS09130	COG0306	phosphate transporter
ETK49_RS09135	COG2046	Belongs to the sulfate adenylyltransferase family
ETK49_RS09140	COG0529	Catalyzes the synthesis of activated sulfate
ETK49_RS09145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETK49_RS09150	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ETK49_RS09155	COG1648	precorrin-2 dehydrogenase activity
ETK49_RS09165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ETK49_RS09170	COG1561	YicC-like family, N-terminal region
ETK49_RS09175	COG2052	Domain of unknown function (DUF370)
ETK49_RS09180	COG0194	GDP metabolic process
ETK49_RS09185	COG1758	RNA polymerase activity
ETK49_RS09190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ETK49_RS09195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ETK49_RS09200	COG0242	peptide deformylase activity
ETK49_RS09205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ETK49_RS09210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ETK49_RS09210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ETK49_RS09215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ETK49_RS09220	COG0631	protein serine/threonine phosphatase activity
ETK49_RS09225	COG0515	serine threonine protein kinase
ETK49_RS09225	COG2815	serine threonine protein kinase
ETK49_RS09230	COG1162	GTPase activity
ETK49_RS09235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ETK49_RS09240	COG1564	THIamine pyrophosphokinase
ETK49_RS09250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ETK49_RS09255	COG1302	Protein conserved in bacteria
ETK49_RS09260	COG1461	Dihydroxyacetone kinase
ETK49_RS09265	COG1760	l-serine dehydratase
ETK49_RS09270	COG1760	l-serine dehydratase
ETK49_RS09275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ETK49_RS09280	COG1349	DNA-binding transcription factor activity
ETK49_RS09285	COG0416	fatty acid biosynthetic process
ETK49_RS09290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ETK49_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS09300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ETK49_RS09305	COG0571	ribonuclease III activity
ETK49_RS09310	COG1196	nuclear chromosome segregation
ETK49_RS09315	COG0552	protein localization to endoplasmic reticulum
ETK49_RS09320	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ETK49_RS09325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ETK49_RS09330	COG0228	four-way junction DNA binding
ETK49_RS09335	COG1837	Belongs to the UPF0109 family
ETK49_RS09345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ETK49_RS09350	COG0336	Belongs to the RNA methyltransferase TrmD family
ETK49_RS09355	COG0335	large ribosomal subunit rRNA binding
ETK49_RS09360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ETK49_RS09365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ETK49_RS09375	COG2257	FlhB HrpN YscU SpaS Family
ETK49_RS09380	COG0045	succinate-CoA ligase (ADP-forming) activity
ETK49_RS09385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ETK49_RS09390	COG0758	DNA mediated transformation
ETK49_RS09395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ETK49_RS09400	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ETK49_RS09405	COG4974	Belongs to the 'phage' integrase family
ETK49_RS09410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ETK49_RS09415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ETK49_RS09420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ETK49_RS09425	COG1815	bacterial-type flagellum-dependent cell motility
ETK49_RS09430	COG1558	bacterial-type flagellum-dependent cell motility
ETK49_RS09435	COG1677	Flagellar hook-basal body complex protein FliE
ETK49_RS09440	COG1766	The M ring may be actively involved in energy transduction
ETK49_RS09445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK49_RS09450	COG1317	bacterial-type flagellum organization
ETK49_RS09455	COG1157	protein secretion by the type III secretion system
ETK49_RS09460	COG2882	bacterial-type flagellum organization
ETK49_RS09470	COG3144	bacterial-type flagellum assembly
ETK49_RS09475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ETK49_RS09480	COG4786	Flagellar basal body rod
ETK49_RS09485	COG1582	Flagellar protein (FlbD)
ETK49_RS09490	COG1580	Controls the rotational direction of flagella during chemotaxis
ETK49_RS09495	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK49_RS09500	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK49_RS09500	COG1776	CheC inhibitor of MCP methylation
ETK49_RS09505	COG2201	protein-glutamate methylesterase activity
ETK49_RS09510	COG3190	flagellar
ETK49_RS09515	COG1338	Plays a role in the flagellum-specific transport system
ETK49_RS09520	COG1987	bacterial-type flagellum assembly
ETK49_RS09525	COG1684	flagellar biosynthetic protein fliR
ETK49_RS09530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETK49_RS09535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETK49_RS09540	COG1419	protein localization to endoplasmic reticulum
ETK49_RS09545	COG0455	bacterial-type flagellum organization
ETK49_RS09550	COG2201	protein-glutamate methylesterase activity
ETK49_RS09555	COG0643	Histidine kinase
ETK49_RS09555	COG2198	Histidine kinase
ETK49_RS09560	COG0835	chemotaxis
ETK49_RS09565	COG1776	CheC inhibitor of MCP methylation
ETK49_RS09570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ETK49_RS09575	COG1191	sigma factor activity
ETK49_RS09585	COG0052	Belongs to the universal ribosomal protein uS2 family
ETK49_RS09590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ETK49_RS09595	COG0528	UMP kinase activity
ETK49_RS09600	COG0233	cytoplasmic translational termination
ETK49_RS09605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ETK49_RS09610	COG4589	Belongs to the CDS family
ETK49_RS09615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ETK49_RS09620	COG0750	zinc metalloprotease
ETK49_RS09625	COG0442	prolyl-tRNA aminoacylation
ETK49_RS09630	COG2176	DNA-directed DNA polymerase activity
ETK49_RS09660	COG0779	Required for maturation of 30S ribosomal subunits
ETK49_RS09665	COG0195	Participates in both transcription termination and antitermination
ETK49_RS09670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ETK49_RS09675	COG1358	cellular component organization or biogenesis
ETK49_RS09680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ETK49_RS09685	COG1550	Protein conserved in bacteria
ETK49_RS09690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ETK49_RS09695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ETK49_RS09700	COG0196	riboflavin kinase activity
ETK49_RS09705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ETK49_RS09710	COG1185	polyribonucleotide nucleotidyltransferase activity
ETK49_RS09715	COG0726	polysaccharide deacetylase
ETK49_RS09720	COG0612	Peptidase, M16
ETK49_RS09725	COG1873	PFAM PRC-barrel domain
ETK49_RS09730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETK49_RS09735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ETK49_RS09740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ETK49_RS09745	COG0527	aspartate kinase activity
ETK49_RS09755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ETK49_RS09760	COG0740	serine-type endopeptidase activity
ETK49_RS09770	COG1674	ftsk spoiiie
ETK49_RS09770	COG4980	gas vesicle protein
ETK49_RS09775	COG2188	Transcriptional regulator
ETK49_RS09780	COG2814	Major facilitator Superfamily
ETK49_RS09785	COG0612	Peptidase, M16
ETK49_RS09790	COG0612	Peptidase, M16
ETK49_RS09795	COG0300	oxidoreductase activity
ETK49_RS09810	COG1426	Protein conserved in bacteria
ETK49_RS09815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ETK49_RS09820	COG1546	Belongs to the CinA family
ETK49_RS09820	COG1058	Belongs to the CinA family
ETK49_RS09830	COG1418	mRNA catabolic process
ETK49_RS09835	COG1692	metallophosphoesterase
ETK49_RS09840	COG2359	stage V sporulation protein S
ETK49_RS09850	COG1063	alcohol dehydrogenase
ETK49_RS09855	COG0156	8-amino-7-oxononanoate synthase activity
ETK49_RS09860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETK49_RS09865	COG4550	Control of competence regulator ComK, YlbF/YmcA
ETK49_RS09875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ETK49_RS09880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ETK49_RS09885	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ETK49_RS09890	COG5444	nuclease activity
ETK49_RS09915	COG0523	cobalamin synthesis protein
ETK49_RS09925	COG1247	-acetyltransferase
ETK49_RS09940	COG1231	oxidoreductase activity
ETK49_RS09945	COG3619	membrane
ETK49_RS09950	COG3263	regulation of cellular component size
ETK49_RS09970	COG0393	Putative heavy-metal-binding
ETK49_RS09975	COG0398	Pfam SNARE associated Golgi protein
ETK49_RS09980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK49_RS09985	COG1819	glycosyl
ETK49_RS09990	COG0531	amino acid
ETK49_RS09995	COG5577	PFAM Coat F domain
ETK49_RS10005	COG3858	chitin binding
ETK49_RS10005	COG1388	LysM domain
ETK49_RS10010	COG1309	transcriptional regulator
ETK49_RS10015	COG3631	Ketosteroid isomerase-related protein
ETK49_RS10020	COG0702	epimerase
ETK49_RS10030	COG1764	response to oxidative stress
ETK49_RS10040	COG2076	Multidrug Resistance protein
ETK49_RS10055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ETK49_RS10060	COG1923	regulation of RNA biosynthetic process
ETK49_RS10075	COG1780	Probably involved in ribonucleotide reductase function
ETK49_RS10080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK49_RS10085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK49_RS10090	COG4112	unkown
ETK49_RS10105	COG0735	belongs to the Fur family
ETK49_RS10110	COG1802	Transcriptional regulator
ETK49_RS10115	COG0697	spore germination
ETK49_RS10150	COG1309	transcriptional regulator
ETK49_RS10200	COG0464	growth
ETK49_RS10205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ETK49_RS10210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ETK49_RS10215	COG0789	Transcriptional regulator
ETK49_RS10220	COG0174	glutamine synthetase
ETK49_RS10260	COG1073	alpha beta
ETK49_RS10300	COG1309	transcriptional regulator
ETK49_RS10305	COG2076	Multidrug Resistance protein
ETK49_RS10310	COG2076	Multidrug Resistance protein
ETK49_RS10315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK49_RS10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS10335	COG3546	catalase activity
ETK49_RS10360	COG1846	Transcriptional regulator
ETK49_RS10365	COG0778	Nitroreductase
ETK49_RS10370	COG0346	lactoylglutathione lyase activity
ETK49_RS10375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ETK49_RS10380	COG0655	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS10400	COG3209	COG3209 Rhs family protein
ETK49_RS10405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ETK49_RS10410	COG1388	LysM domain
ETK49_RS10415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK49_RS10420	COG4224	UPF0291 protein
ETK49_RS10425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ETK49_RS10435	COG3763	UPF0154 protein
ETK49_RS10445	COG0785	Cytochrome C biogenesis protein
ETK49_RS10450	COG2201	protein-glutamate methylesterase activity
ETK49_RS10455	COG4846	Membrane protein involved in cytochrome C biogenesis
ETK49_RS10465	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK49_RS10480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ETK49_RS10485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS10505	COG0824	Thioesterase
ETK49_RS10530	COG4841	protein insertion into membrane
ETK49_RS10535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ETK49_RS10540	COG1832	CoA-binding protein
ETK49_RS10545	COG0187	DNA topoisomerase II activity
ETK49_RS10550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ETK49_RS10555	COG1609	Transcriptional regulator
ETK49_RS10570	COG2160	L-arabinose isomerase activity
ETK49_RS10590	COG1115	amino acid carrier protein
ETK49_RS10600	COG2181	nitrate reductase activity
ETK49_RS10605	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ETK49_RS10610	COG1140	nitrate reductase beta subunit
ETK49_RS10615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ETK49_RS10630	COG0535	radical SAM domain protein
ETK49_RS10635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ETK49_RS10645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ETK49_RS10650	COG2223	nitrite transmembrane transporter activity
ETK49_RS10660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ETK49_RS10670	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ETK49_RS10680	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ETK49_RS10690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK49_RS10700	COG0477	Major facilitator Superfamily
ETK49_RS10705	COG3420	alginic acid biosynthetic process
ETK49_RS10710	COG1114	Component of the transport system for branched-chain amino acids
ETK49_RS10720	COG0789	Transcriptional regulator
ETK49_RS10745	COG1024	Enoyl-CoA hydratase
ETK49_RS10750	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS10755	COG2084	Dehydrogenase
ETK49_RS10760	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS10765	COG1482	cell wall glycoprotein biosynthetic process
ETK49_RS10770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS10770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS10770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS10795	COG3711	transcriptional antiterminator
ETK49_RS10795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS10810	COG1725	Transcriptional regulator
ETK49_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS10820	COG1312	Catalyzes the dehydration of D-mannonate
ETK49_RS10835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ETK49_RS10845	COG1609	Transcriptional regulator
ETK49_RS10850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK49_RS10855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ETK49_RS10860	COG0640	Transcriptional regulator
ETK49_RS10870	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ETK49_RS10885	COG1649	PFAM Uncharacterised BCR, COG1649
ETK49_RS10890	COG2404	hydrolase activity, acting on ester bonds
ETK49_RS10895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ETK49_RS10905	COG2027	D-alanyl-D-alanine carboxypeptidase
ETK49_RS10910	COG1252	NADH dehydrogenase
ETK49_RS10925	COG0166	Belongs to the GPI family
ETK49_RS10935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETK49_RS10940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ETK49_RS10945	COG1024	Enoyl-CoA hydratase
ETK49_RS10950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ETK49_RS10955	COG0511	ligase activity, forming carbon-carbon bonds
ETK49_RS10960	COG0439	Biotin carboxylase
ETK49_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS10970	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS10975	COG2249	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS10980	COG1733	regulation of RNA biosynthetic process
ETK49_RS10985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ETK49_RS10990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ETK49_RS11000	COG2323	membrane
ETK49_RS11010	COG0306	phosphate transporter
ETK49_RS11015	COG0175	sulfate reduction
ETK49_RS11020	COG1809	phosphosulfolactate synthase activity
ETK49_RS11025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS11030	COG4948	Mandelate Racemase Muconate Lactonizing
ETK49_RS11035	COG2814	Major facilitator Superfamily
ETK49_RS11040	COG0463	Glycosyl transferase, family 2
ETK49_RS11055	COG0493	'glutamate synthase
ETK49_RS11060	COG0070	glutamate synthase
ETK49_RS11060	COG0067	glutamate synthase
ETK49_RS11060	COG0069	glutamate synthase activity
ETK49_RS11065	COG0583	DNA-binding transcription factor activity
ETK49_RS11085	COG1846	Transcriptional regulator
ETK49_RS11095	COG1132	(ABC) transporter
ETK49_RS11105	COG0300	oxidoreductase activity
ETK49_RS11110	COG0574	Belongs to the PEP-utilizing enzyme family
ETK49_RS11110	COG3848	Pyruvate phosphate dikinase
ETK49_RS11120	COG0477	Major facilitator Superfamily
ETK49_RS11125	COG0243	molybdopterin cofactor binding
ETK49_RS11130	COG1846	Transcriptional regulator
ETK49_RS11140	COG0531	amino acid
ETK49_RS11150	COG0531	amino acid
ETK49_RS11155	COG0531	amino acid
ETK49_RS11160	COG0697	spore germination
ETK49_RS11165	COG0488	(ABC) transporter
ETK49_RS11170	COG0840	transmembrane signaling receptor activity
ETK49_RS11175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK49_RS11180	COG1404	Belongs to the peptidase S8 family
ETK49_RS11190	COG1309	transcriptional regulator
ETK49_RS11195	COG1846	Transcriptional regulator
ETK49_RS11225	COG1309	transcriptional regulator
ETK49_RS11230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS11235	COG3708	Transcriptional regulator
ETK49_RS11245	COG2378	regulation of single-species biofilm formation
ETK49_RS11255	COG0640	Transcriptional regulator
ETK49_RS11260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS11270	COG0531	amino acid
ETK49_RS11275	COG0741	lytic transglycosylase activity
ETK49_RS11280	COG1086	Polysaccharide biosynthesis protein
ETK49_RS11300	COG2322	membrane
ETK49_RS11315	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS11320	COG3584	3D domain protein
ETK49_RS11320	COG1388	LysM domain
ETK49_RS11325	COG0514	ATP-dependent DNA helicase (RecQ)
ETK49_RS11345	COG2315	Protein conserved in bacteria
ETK49_RS11365	COG2427	Protein of unknown function (DUF1641)
ETK49_RS11390	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ETK49_RS11440	COG0402	S-adenosylhomocysteine deaminase activity
ETK49_RS11455	COG2267	carboxylic ester hydrolase activity
ETK49_RS11470	COG1280	lysine exporter protein (LysE YggA)
ETK49_RS11475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ETK49_RS11485	COG0574	Belongs to the PEP-utilizing enzyme family
ETK49_RS11485	COG3848	Pyruvate phosphate dikinase
ETK49_RS11490	COG1309	transcriptional regulator
ETK49_RS11505	COG2318	DinB family
ETK49_RS11510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ETK49_RS11515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK49_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS11535	COG2814	Major facilitator Superfamily
ETK49_RS11550	COG1657	PFAM Prenyltransferase squalene oxidase
ETK49_RS11555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ETK49_RS11565	COG0733	neurotransmitter:sodium symporter activity
ETK49_RS11570	COG0385	Bile acid
ETK49_RS11575	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK49_RS11580	COG0567	Dehydrogenase, E1 component
ETK49_RS11585	COG4548	von Willebrand factor, type A
ETK49_RS11590	COG0714	Associated with various cellular activities
ETK49_RS11595	COG2032	superoxide dismutase activity
ETK49_RS11600	COG1388	LysM domain
ETK49_RS11600	COG0791	NLP P60 protein
ETK49_RS11610	COG0534	Mate efflux family protein
ETK49_RS11615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK49_RS11620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK49_RS11630	COG2962	Rard protein
ETK49_RS11640	COG4305	rare lipoprotein A
ETK49_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS11655	COG1733	regulation of RNA biosynthetic process
ETK49_RS11660	COG0778	Nitroreductase
ETK49_RS11665	COG0400	carboxylic ester hydrolase activity
ETK49_RS11675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS11685	COG0793	Belongs to the peptidase S41A family
ETK49_RS11685	COG3409	Peptidoglycan-binding domain 1 protein
ETK49_RS11690	COG2226	methyltransferase
ETK49_RS11700	COG1876	peptidase activity
ETK49_RS11705	COG0813	purine-nucleoside phosphorylase activity
ETK49_RS11710	COG0701	Predicted permease
ETK49_RS11730	COG0671	phosphoesterase, PA-phosphatase related
ETK49_RS11745	COG4479	Belongs to the UPF0346 family
ETK49_RS11755	COG1509	lysine 2,3-aminomutase activity
ETK49_RS11760	COG0456	acetyltransferase
ETK49_RS11765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK49_RS11770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ETK49_RS11775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ETK49_RS11780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK49_RS11795	COG0456	acetyltransferase
ETK49_RS11800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK49_RS11805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK49_RS11810	COG1846	Transcriptional regulator
ETK49_RS11820	COG3706	GGDEF domain
ETK49_RS11825	COG0534	Mate efflux family protein
ETK49_RS11840	COG4698	Protein conserved in bacteria
ETK49_RS11845	COG2755	lipolytic protein G-D-S-L family
ETK49_RS11850	COG1999	signal sequence binding
ETK49_RS11865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ETK49_RS11870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ETK49_RS11875	COG1272	protein, Hemolysin III
ETK49_RS11880	COG0204	Acyl-transferase
ETK49_RS11885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ETK49_RS11890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ETK49_RS11900	COG2521	methyltransferase
ETK49_RS11900	COG2136	Putative SAM-dependent methyltransferase
ETK49_RS11910	COG0129	dihydroxy-acid dehydratase activity
ETK49_RS11915	COG1413	lyase activity
ETK49_RS11920	COG1418	mRNA catabolic process
ETK49_RS11925	COG0386	Belongs to the glutathione peroxidase family
ETK49_RS11930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ETK49_RS11935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ETK49_RS11940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK49_RS11950	COG1278	Cold shock
ETK49_RS11970	COG0328	RNA-DNA hybrid ribonuclease activity
ETK49_RS11975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ETK49_RS11980	COG0328	RNA-DNA hybrid ribonuclease activity
ETK49_RS11990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK49_RS12000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ETK49_RS12010	COG1755	Isoprenylcysteine carboxyl methyltransferase
ETK49_RS12015	COG3424	synthase
ETK49_RS12020	COG0456	acetyltransferase
ETK49_RS12025	COG2233	PERMEase
ETK49_RS12030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK49_RS12035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ETK49_RS12040	COG1199	ATP-dependent helicase activity
ETK49_RS12050	COG0116	Belongs to the methyltransferase superfamily
ETK49_RS12060	COG3599	regulation of cell shape
ETK49_RS12065	COG4474	Belongs to the UPF0398 family
ETK49_RS12075	COG3359	exonuclease
ETK49_RS12080	COG1111	helicase
ETK49_RS12080	COG1205	dead DEAH box helicase
ETK49_RS12085	COG2190	(PTS) system
ETK49_RS12090	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK49_RS12125	COG3331	DNA recombination
ETK49_RS12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK49_RS12130	COG4499	WXG100 protein secretion system (Wss), protein YukC
ETK49_RS12140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ETK49_RS12145	COG3935	DnaD domain protein
ETK49_RS12150	COG0017	Asparaginyl-tRNA synthetase
ETK49_RS12155	COG0436	Aminotransferase
ETK49_RS12160	COG5353	protein conserved in bacteria
ETK49_RS12170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ETK49_RS12170	COG1199	ATP-dependent helicase activity
ETK49_RS12175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ETK49_RS12180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ETK49_RS12185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ETK49_RS12200	COG0617	tRNA 3'-terminal CCA addition
ETK49_RS12205	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS12210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK49_RS12215	COG1803	Methylglyoxal synthase
ETK49_RS12220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ETK49_RS12225	COG1694	Mazg nucleotide pyrophosphohydrolase
ETK49_RS12230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS12240	COG4347	Protein of unknown function (DUF1405)
ETK49_RS12245	COG2010	Cytochrome c
ETK49_RS12245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ETK49_RS12250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ETK49_RS12255	COG0723	plastoquinol--plastocyanin reductase activity
ETK49_RS12265	COG5582	Belongs to the UPF0302 family
ETK49_RS12270	COG0457	Tetratricopeptide repeat
ETK49_RS12275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ETK49_RS12280	COG0287	Prephenate dehydrogenase
ETK49_RS12285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ETK49_RS12290	COG0159	tryptophan synthase activity
ETK49_RS12295	COG0133	tryptophan synthase activity
ETK49_RS12300	COG0135	phosphoribosylanthranilate isomerase activity
ETK49_RS12305	COG0134	indole-3-glycerol-phosphate synthase activity
ETK49_RS12310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETK49_RS12315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETK49_RS12320	COG4401	Chorismate mutase type I
ETK49_RS12325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ETK49_RS12330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ETK49_RS12335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ETK49_RS12340	COG0105	UTP biosynthetic process
ETK49_RS12345	COG0142	geranyltranstransferase activity
ETK49_RS12350	COG2226	methyltransferase
ETK49_RS12355	COG0142	geranyltranstransferase activity
ETK49_RS12370	COG0776	regulation of translation
ETK49_RS12375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ETK49_RS12395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ETK49_RS12400	COG1160	GTP binding
ETK49_RS12425	COG1304	FMN binding
ETK49_RS12430	COG0539	negative regulation of cytoplasmic translation
ETK49_RS12435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ETK49_RS12440	COG2959	enzyme of heme biosynthesis
ETK49_RS12445	COG3773	Cell wall hydrolase
ETK49_RS12445	COG3409	Peptidoglycan-binding domain 1 protein
ETK49_RS12450	COG2339	peptidase activity
ETK49_RS12460	COG0492	ferredoxin-NADP+ reductase activity
ETK49_RS12465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETK49_RS12470	COG4862	establishment of competence for transformation
ETK49_RS12475	COG1408	metallophosphoesterase
ETK49_RS12485	COG1388	LysM domain
ETK49_RS12490	COG1266	CAAX protease self-immunity
ETK49_RS12495	COG0514	ATP-dependent DNA helicase (RecQ)
ETK49_RS12500	COG4955	Helix-turn-helix domain
ETK49_RS12505	COG1141	Ferredoxin
ETK49_RS12510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ETK49_RS12515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ETK49_RS12520	COG0739	heme binding
ETK49_RS12530	COG1595	DNA-templated transcription, initiation
ETK49_RS12535	COG1316	TRANSCRIPTIONal
ETK49_RS12550	COG5002	protein histidine kinase activity
ETK49_RS12555	COG0745	RESPONSE REGULATOR receiver
ETK49_RS12560	COG5002	protein histidine kinase activity
ETK49_RS12565	COG0745	RESPONSE REGULATOR receiver
ETK49_RS12570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ETK49_RS12575	COG1333	cytochrome c biogenesis protein
ETK49_RS12580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS12585	COG1187	pseudouridine synthase activity
ETK49_RS12590	COG0700	Nucleoside recognition
ETK49_RS12595	COG2715	membrane protein required for spore maturation
ETK49_RS12600	COG1686	Belongs to the peptidase S11 family
ETK49_RS12610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ETK49_RS12615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ETK49_RS12625	COG1547	Domain of unknown function (DUF309)
ETK49_RS12630	COG0456	acetyltransferase
ETK49_RS12635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ETK49_RS12640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ETK49_RS12640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ETK49_RS12645	COG0307	riboflavin synthase, alpha
ETK49_RS12650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETK49_RS12650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETK49_RS12675	COG0457	Tetratricopeptide repeat
ETK49_RS12680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ETK49_RS12685	COG4086	secreted protein
ETK49_RS12690	COG4195	phage-related replication protein
ETK49_RS12695	COG0019	diaminopimelate decarboxylase activity
ETK49_RS12705	COG0697	spore germination
ETK49_RS12720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK49_RS12755	COG1686	Belongs to the peptidase S11 family
ETK49_RS12760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ETK49_RS12765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ETK49_RS12770	COG4974	Belongs to the 'phage' integrase family
ETK49_RS12780	COG0735	belongs to the Fur family
ETK49_RS12785	COG1300	Membrane
ETK49_RS12790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS12810	COG2153	protein acetylation
ETK49_RS12815	COG1379	DNA repair
ETK49_RS12820	COG0494	nUDIX hydrolase
ETK49_RS12830	COG1309	transcriptional regulator
ETK49_RS12840	COG0667	Aldo Keto reductase
ETK49_RS12850	COG1073	alpha beta
ETK49_RS12860	COG4918	Iron-sulphur cluster biosynthesis
ETK49_RS12870	COG0456	acetyltransferase
ETK49_RS12870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ETK49_RS12875	COG2329	Antibiotic biosynthesis monooxygenase
ETK49_RS12885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ETK49_RS12895	COG0747	negative chemotaxis
ETK49_RS12900	COG0601	transmembrane transport
ETK49_RS12910	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS12920	COG0534	Mate efflux family protein
ETK49_RS12935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK49_RS12950	COG0346	lactoylglutathione lyase activity
ETK49_RS12955	COG1072	(Pantothenic acid kinase))
ETK49_RS12970	COG1131	(ABC) transporter
ETK49_RS12990	COG4195	phage-related replication protein
ETK49_RS13000	COG0300	oxidoreductase activity
ETK49_RS13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS13010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK49_RS13015	COG4187	Peptidase family M20/M25/M40
ETK49_RS13020	COG1902	pentaerythritol trinitrate reductase activity
ETK49_RS13025	COG0596	Alpha beta hydrolase
ETK49_RS13030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ETK49_RS13035	COG1234	tRNA 3'-trailer cleavage
ETK49_RS13040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ETK49_RS13055	COG2358	TRAP transporter, solute receptor (TAXI family
ETK49_RS13060	COG2188	Transcriptional regulator
ETK49_RS13065	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS13070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS13075	COG1447	Phosphotransferase system cellobiose-specific component IIA
ETK49_RS13080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS13085	COG1785	Belongs to the alkaline phosphatase family
ETK49_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS13095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ETK49_RS13100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK49_RS13110	COG0706	membrane insertase activity
ETK49_RS13115	COG2195	Cleaves the N-terminal amino acid of tripeptides
ETK49_RS13120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ETK49_RS13125	COG4129	membrane
ETK49_RS13130	COG1126	abc transporter atp-binding protein
ETK49_RS13135	COG0765	amino acid transport
ETK49_RS13140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK49_RS13150	COG1597	lipid kinase activity
ETK49_RS13155	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK49_RS13160	COG0022	dehydrogenase e1 component
ETK49_RS13165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK49_RS13170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK49_RS13175	COG3426	butyrate kinase activity
ETK49_RS13185	COG0280	phosphate acetyltransferase
ETK49_RS13190	COG3290	protein histidine kinase activity
ETK49_RS13190	COG3829	transcription factor binding
ETK49_RS13200	COG0584	glycerophosphoryl diester phosphodiesterase
ETK49_RS13205	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS13220	COG1045	serine acetyltransferase
ETK49_RS13230	COG0745	RESPONSE REGULATOR receiver
ETK49_RS13235	COG0750	zinc metalloprotease
ETK49_RS13240	COG0497	DNA recombination
ETK49_RS13245	COG1438	arginine binding
ETK49_RS13250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ETK49_RS13255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ETK49_RS13260	COG0142	geranyltranstransferase activity
ETK49_RS13265	COG1722	exodeoxyribonuclease VII activity
ETK49_RS13270	COG1570	exodeoxyribonuclease VII activity
ETK49_RS13275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ETK49_RS13280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ETK49_RS13285	COG1302	Protein conserved in bacteria
ETK49_RS13290	COG0439	Biotin carboxylase
ETK49_RS13295	COG0511	ligase activity, forming carbon-carbon bonds
ETK49_RS13335	COG3854	ATPases associated with a variety of cellular activities
ETK49_RS13345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ETK49_RS13350	COG0006	proline dipeptidase activity
ETK49_RS13355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ETK49_RS13365	COG3872	metal-dependent enzyme
ETK49_RS13375	COG1752	Esterase of the alpha-beta hydrolase superfamily
ETK49_RS13380	COG1321	iron dependent repressor
ETK49_RS13385	COG0095	Lipoate-protein ligase
ETK49_RS13390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK49_RS13395	COG2113	Glycine betaine
ETK49_RS13400	COG4176	ABC-type proline glycine betaine transport system permease component
ETK49_RS13405	COG0517	IMP dehydrogenase activity
ETK49_RS13405	COG4175	Glycine betaine
ETK49_RS13410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ETK49_RS13415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ETK49_RS13420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ETK49_RS13425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ETK49_RS13450	COG0681	Belongs to the peptidase S26 family
ETK49_RS13475	COG4940	Competence protein ComGF
ETK49_RS13485	COG4970	Tfp pilus assembly protein FimT
ETK49_RS13490	COG4537	Required for transformation and DNA binding
ETK49_RS13495	COG1459	type II secretion system
ETK49_RS13500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ETK49_RS13505	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK49_RS13515	COG1393	Belongs to the ArsC family
ETK49_RS13525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS13535	COG0011	TIGRFAM Protein of
ETK49_RS13545	COG2866	Carboxypeptidase
ETK49_RS13550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS13555	COG1368	sulfuric ester hydrolase activity
ETK49_RS13560	COG1940	carbohydrate kinase activity
ETK49_RS13565	COG4483	Protein conserved in bacteria
ETK49_RS13570	COG0697	spore germination
ETK49_RS13575	COG0705	Rhomboid family
ETK49_RS13575	COG0457	Tetratricopeptide repeat
ETK49_RS13580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ETK49_RS13585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ETK49_RS13590	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS13605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ETK49_RS13610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETK49_RS13615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETK49_RS13620	COG0581	inorganic phosphate transmembrane transporter activity
ETK49_RS13625	COG0573	inorganic phosphate transmembrane transporter activity
ETK49_RS13630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ETK49_RS13635	COG0768	penicillin binding
ETK49_RS13640	COG0477	Major facilitator Superfamily
ETK49_RS13645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ETK49_RS13650	COG2839	Protein conserved in bacteria
ETK49_RS13655	COG5521	maltodextrose utilization protein MalA
ETK49_RS13660	COG1388	LysM domain
ETK49_RS13665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ETK49_RS13670	COG4709	membrane
ETK49_RS13675	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ETK49_RS13680	COG0735	belongs to the Fur family
ETK49_RS13685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETK49_RS13690	COG1121	(ABC) transporter
ETK49_RS13695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS13705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ETK49_RS13710	COG0513	Belongs to the DEAD box helicase family
ETK49_RS13720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ETK49_RS13725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ETK49_RS13730	COG2384	SAM-dependent methyltransferase
ETK49_RS13780	COG5444	nuclease activity
ETK49_RS13795	COG2010	Cytochrome c
ETK49_RS13800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ETK49_RS13805	COG0358	DNA primase activity
ETK49_RS13810	COG1671	Belongs to the UPF0178 family
ETK49_RS13815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ETK49_RS13820	COG0517	IMP dehydrogenase activity
ETK49_RS13825	COG0751	glycine-tRNA ligase activity
ETK49_RS13830	COG0752	glycyl-tRNA synthetase alpha subunit
ETK49_RS13835	COG1381	Involved in DNA repair and RecF pathway recombination
ETK49_RS13845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ETK49_RS13850	COG0295	cytidine deaminase activity
ETK49_RS13855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ETK49_RS13860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ETK49_RS13865	COG1480	7TM receptor with intracellular HD hydrolase
ETK49_RS13870	COG1702	phosphate starvation-inducible protein PhoH
ETK49_RS13875	COG0561	phosphatase activity
ETK49_RS13890	COG4864	UPF0365 protein
ETK49_RS13895	COG1030	water channel activity
ETK49_RS13900	COG1610	YqeY-like protein
ETK49_RS13905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ETK49_RS13910	COG1283	sodium-dependent phosphate transmembrane transporter activity
ETK49_RS13915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ETK49_RS13920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETK49_RS13925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ETK49_RS13930	COG2264	protein methyltransferase activity
ETK49_RS13935	COG0484	heat shock protein binding
ETK49_RS13940	COG0443	Heat shock 70 kDa protein
ETK49_RS13945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ETK49_RS13950	COG1420	regulation of RNA biosynthetic process
ETK49_RS13955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETK49_RS13960	COG0481	GTPase activity
ETK49_RS13970	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS13975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ETK49_RS13980	COG0268	Binds directly to 16S ribosomal RNA
ETK49_RS13985	COG1466	dna polymerase III delta subunit
ETK49_RS13995	COG2333	competence protein COMEC
ETK49_RS13995	COG0658	competence protein
ETK49_RS14000	COG2131	deaminase
ETK49_RS14005	COG1555	photosystem II stabilization
ETK49_RS14005	COG1596	polysaccharide export
ETK49_RS14010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK49_RS14015	COG2226	methyltransferase
ETK49_RS14020	COG0799	negative regulation of ribosome biogenesis
ETK49_RS14025	COG1713	HD superfamily hydrolase involved in NAD metabolism
ETK49_RS14030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ETK49_RS14035	COG1534	Rna-binding protein
ETK49_RS14040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ETK49_RS14045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ETK49_RS14050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ETK49_RS14060	COG2755	lipolytic protein G-D-S-L family
ETK49_RS14070	COG5609	conserved protein (DUF2294)
ETK49_RS14075	COG3383	formate dehydrogenase (NAD+) activity
ETK49_RS14080	COG2427	Protein of unknown function (DUF1641)
ETK49_RS14100	COG0457	Tetratricopeptide repeat
ETK49_RS14105	COG5444	nuclease activity
ETK49_RS14135	COG1793	dna ligase
ETK49_RS14225	COG0629	single-stranded DNA binding
ETK49_RS14270	COG0739	heme binding
ETK49_RS14390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ETK49_RS14480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK49_RS14510	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS14525	COG1247	-acetyltransferase
ETK49_RS14540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ETK49_RS14545	COG3616	Alanine racemase, N-terminal domain
ETK49_RS14550	COG0251	oxidation-reduction process
ETK49_RS14560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK49_RS14565	COG0251	oxidation-reduction process
ETK49_RS14585	COG0789	Transcriptional regulator
ETK49_RS14585	COG4978	Transcriptional regulator
ETK49_RS14590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK49_RS14590	COG0425	Belongs to the sulfur carrier protein TusA family
ETK49_RS14600	COG2197	response regulator
ETK49_RS14605	COG4585	Histidine kinase
ETK49_RS14610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS14620	COG0425	Belongs to the sulfur carrier protein TusA family
ETK49_RS14625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS14625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK49_RS14630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK49_RS14630	COG0425	Belongs to the sulfur carrier protein TusA family
ETK49_RS14635	COG2210	Belongs to the sulfur carrier protein TusA family
ETK49_RS14640	COG1937	Protein conserved in bacteria
ETK49_RS14685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ETK49_RS14690	COG0113	porphobilinogen synthase activity
ETK49_RS14695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ETK49_RS14700	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ETK49_RS14710	COG3239	Fatty acid desaturase
ETK49_RS14715	COG4585	Histidine kinase
ETK49_RS14720	COG2197	response regulator
ETK49_RS14725	COG0492	ferredoxin-NADP+ reductase activity
ETK49_RS14730	COG0747	negative chemotaxis
ETK49_RS14735	COG0601	transmembrane transport
ETK49_RS14740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK49_RS14745	COG0444	Belongs to the ABC transporter superfamily
ETK49_RS14750	COG4608	Belongs to the ABC transporter superfamily
ETK49_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS14790	COG0730	response to heat
ETK49_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS14815	COG3716	PTS system mannose fructose sorbose family IID component
ETK49_RS14820	COG3715	PTS system
ETK49_RS14825	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS14830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS14835	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ETK49_RS14835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ETK49_RS14860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ETK49_RS14865	COG0656	L-ascorbic acid biosynthetic process
ETK49_RS14870	COG2814	Major facilitator Superfamily
ETK49_RS14875	COG1733	regulation of RNA biosynthetic process
ETK49_RS14880	COG3340	Belongs to the peptidase S51 family
ETK49_RS14885	COG1587	Uroporphyrinogen-III synthase
ETK49_RS14895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS14900	COG0583	DNA-binding transcription factor activity
ETK49_RS14905	COG2814	Major facilitator Superfamily
ETK49_RS14915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ETK49_RS14915	COG2124	cytochrome p450
ETK49_RS14920	COG1309	transcriptional regulator
ETK49_RS14925	COG1404	Belongs to the peptidase S8 family
ETK49_RS14930	COG2226	methyltransferase
ETK49_RS14950	COG0626	cystathionine gamma-synthase activity
ETK49_RS14955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK49_RS14960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ETK49_RS14965	COG2226	methyltransferase
ETK49_RS14980	COG0768	penicillin binding
ETK49_RS14985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ETK49_RS14990	COG0572	uridine kinase
ETK49_RS14995	COG0826	peptidase U32
ETK49_RS15000	COG0826	peptidase U32
ETK49_RS15005	COG4122	O-methyltransferase activity
ETK49_RS15010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ETK49_RS15015	COG3906	Belongs to the UPF0473 family
ETK49_RS15020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ETK49_RS15025	COG4472	Bacterial protein of unknown function (DUF965)
ETK49_RS15050	COG3881	PFAM PRC-barrel domain
ETK49_RS15055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ETK49_RS15060	COG0457	Tetratricopeptide repeat
ETK49_RS15065	COG0482	sulfurtransferase activity
ETK49_RS15070	COG1104	cysteine desulfurase activity
ETK49_RS15075	COG1959	2 iron, 2 sulfur cluster binding
ETK49_RS15080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ETK49_RS15085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ETK49_RS15095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ETK49_RS15100	COG0124	histidyl-tRNA synthetase
ETK49_RS15105	COG4991	sh3 domain protein
ETK49_RS15105	COG3103	Sh3 type 3 domain protein
ETK49_RS15105	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS15110	COG1490	D-aminoacyl-tRNA deacylase activity
ETK49_RS15115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ETK49_RS15120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK49_RS15125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ETK49_RS15125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ETK49_RS15130	COG5416	Lipopolysaccharide assembly protein A domain
ETK49_RS15135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETK49_RS15135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETK49_RS15145	COG2244	polysaccharide biosynthetic process
ETK49_RS15150	COG2323	membrane
ETK49_RS15160	COG1862	Preprotein translocase
ETK49_RS15165	COG0343	queuine tRNA-ribosyltransferase activity
ETK49_RS15170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ETK49_RS15180	COG2255	four-way junction helicase activity
ETK49_RS15185	COG0632	four-way junction helicase activity
ETK49_RS15195	COG2112	serine threonine protein kinase
ETK49_RS15205	COG2318	DinB family
ETK49_RS15210	COG4195	phage-related replication protein
ETK49_RS15225	COG0217	transcriptional regulatory protein
ETK49_RS15235	COG1388	LysM domain
ETK49_RS15240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ETK49_RS15245	COG0157	Belongs to the NadC ModD family
ETK49_RS15250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ETK49_RS15255	COG1104	cysteine desulfurase activity
ETK49_RS15260	COG1827	regulation of RNA biosynthetic process
ETK49_RS15265	COG0077	Prephenate dehydratase
ETK49_RS15270	COG4492	Belongs to the UPF0735 family
ETK49_RS15275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ETK49_RS15280	COG3290	protein histidine kinase activity
ETK49_RS15285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ETK49_RS15290	COG2868	ribosomal protein
ETK49_RS15295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ETK49_RS15300	COG1994	Peptidase M50
ETK49_RS15305	COG0739	heme binding
ETK49_RS15310	COG3832	glyoxalase III activity
ETK49_RS15315	COG0640	Transcriptional regulator
ETK49_RS15320	COG2894	cell division
ETK49_RS15325	COG0850	regulation of cytokinetic process
ETK49_RS15330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ETK49_RS15340	COG1077	Cell shape determining protein MreB Mrl
ETK49_RS15345	COG2003	Belongs to the UPF0758 family
ETK49_RS15350	COG0424	maF-like protein
ETK49_RS15360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ETK49_RS15365	COG0285	dihydrofolate synthase activity
ETK49_RS15370	COG0525	valine-tRNA ligase activity
ETK49_RS15380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK49_RS15385	COG1388	LysM domain
ETK49_RS15390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETK49_RS15395	COG0113	porphobilinogen synthase activity
ETK49_RS15400	COG1587	Uroporphyrinogen-III synthase
ETK49_RS15405	COG0181	hydroxymethylbilane synthase activity
ETK49_RS15410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ETK49_RS15415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ETK49_RS15425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ETK49_RS15430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ETK49_RS15435	COG0470	DNA polymerase III
ETK49_RS15435	COG1067	ATP-dependent peptidase activity
ETK49_RS15440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ETK49_RS15445	COG0544	peptidyl-prolyl cis-trans isomerase activity
ETK49_RS15450	COG0457	Tetratricopeptide repeat
ETK49_RS15450	COG1477	protein flavinylation
ETK49_RS15455	COG0066	3-isopropylmalate dehydratase activity
ETK49_RS15460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ETK49_RS15465	COG0473	3-isopropylmalate dehydrogenase activity
ETK49_RS15470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ETK49_RS15475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ETK49_RS15480	COG0440	acetolactate synthase activity
ETK49_RS15485	COG0028	Belongs to the TPP enzyme family
ETK49_RS15490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK49_RS15500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETK49_RS15520	COG5518	Phage portal protein
ETK49_RS15565	COG5444	nuclease activity
ETK49_RS15570	COG0457	Tetratricopeptide repeat
ETK49_RS15590	COG0622	Phosphoesterase
ETK49_RS15595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ETK49_RS15600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ETK49_RS15605	COG5401	PFAM Sporulation and spore germination
ETK49_RS15610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ETK49_RS15615	COG1846	Transcriptional regulator
ETK49_RS15620	COG2197	response regulator
ETK49_RS15625	COG4221	oxidoreductase activity
ETK49_RS15630	COG0824	Thioesterase
ETK49_RS15635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ETK49_RS15640	COG1053	succinate dehydrogenase
ETK49_RS15645	COG2009	succinate dehydrogenase
ETK49_RS15650	COG1719	4-vinyl reductase, 4VR
ETK49_RS15655	COG0527	aspartate kinase activity
ETK49_RS15665	COG0322	excinuclease ABC activity
ETK49_RS15670	COG3118	belongs to the thioredoxin family
ETK49_RS15675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ETK49_RS15680	COG2086	electron transfer activity
ETK49_RS15685	COG1024	Enoyl-CoA hydratase
ETK49_RS15690	COG1309	transcriptional regulator
ETK49_RS15695	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS15700	COG3766	membrane
ETK49_RS15705	COG1193	negative regulation of DNA recombination
ETK49_RS15710	COG1796	DNA polymerase
ETK49_RS15710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETK49_RS15715	COG1286	toxin biosynthetic process
ETK49_RS15720	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ETK49_RS15725	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ETK49_RS15755	COG1137	ATPase activity
ETK49_RS15770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK49_RS15770	COG0072	phenylalanine-tRNA ligase activity
ETK49_RS15775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ETK49_RS15780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETK49_RS15790	COG1966	Carbon starvation protein
ETK49_RS15805	COG0395	ABC-type sugar transport system, permease component
ETK49_RS15810	COG1175	transmembrane transport
ETK49_RS15815	COG1653	transport
ETK49_RS15820	COG0371	Dehydrogenase
ETK49_RS15825	COG0235	Class ii aldolase
ETK49_RS15830	COG1069	ribulokinase activity
ETK49_RS15835	COG2160	L-arabinose isomerase activity
ETK49_RS15840	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK49_RS15845	COG1363	Peptidase, m42
ETK49_RS15855	COG3326	Membrane
ETK49_RS15860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ETK49_RS15865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ETK49_RS15870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ETK49_RS15875	COG1346	cytolysis
ETK49_RS15885	COG3540	Alkaline phosphatase
ETK49_RS15890	COG3279	Response regulator of the LytR AlgR family
ETK49_RS15895	COG3275	phosphorelay sensor kinase activity
ETK49_RS15905	COG1011	Hydrolase
ETK49_RS15910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ETK49_RS15920	COG0398	Pfam SNARE associated Golgi protein
ETK49_RS15925	COG1484	DNA-dependent DNA replication
ETK49_RS15930	COG3611	Membrane attachment protein
ETK49_RS15935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ETK49_RS15950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ETK49_RS15955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ETK49_RS15960	COG3866	Pectate lyase
ETK49_RS15965	COG0237	dephospho-CoA kinase activity
ETK49_RS15970	COG1971	Probably functions as a manganese efflux pump
ETK49_RS15975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ETK49_RS15980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK49_RS15980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK49_RS15985	COG5002	protein histidine kinase activity
ETK49_RS15990	COG0745	RESPONSE REGULATOR receiver
ETK49_RS15995	COG0039	L-malate dehydrogenase activity
ETK49_RS16000	COG0538	isocitrate dehydrogenase activity
ETK49_RS16005	COG0372	Belongs to the citrate synthase family
ETK49_RS16010	COG2707	UPF0756 membrane protein
ETK49_RS16015	COG0628	permease
ETK49_RS16020	COG3030	protein affecting phage T7 exclusion by the F plasmid
ETK49_RS16030	COG0205	6-phosphofructokinase activity
ETK49_RS16035	COG0825	malonyl-CoA metabolic process
ETK49_RS16040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ETK49_RS16045	COG0281	malic enzyme
ETK49_RS16050	COG0587	DNA-directed DNA polymerase activity
ETK49_RS16070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ETK49_RS16080	COG4109	DRTGG domain
ETK49_RS16085	COG1695	Transcriptional regulator
ETK49_RS16090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ETK49_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS16100	COG0165	Argininosuccinate lyase
ETK49_RS16105	COG0137	argininosuccinate synthase activity
ETK49_RS16110	COG0521	Mo-molybdopterin cofactor biosynthetic process
ETK49_RS16115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ETK49_RS16120	COG0827	DNA restriction-modification system
ETK49_RS16125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ETK49_RS16130	COG3874	Sporulation protein YtfJ
ETK49_RS16140	COG1714	RDD family
ETK49_RS16145	COG0616	signal peptide processing
ETK49_RS16150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ETK49_RS16155	COG1566	PFAM secretion protein HlyD family protein
ETK49_RS16160	COG0477	Major facilitator Superfamily
ETK49_RS16170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETK49_RS16180	COG0301	tRNA thio-modification
ETK49_RS16185	COG1104	cysteine desulfurase activity
ETK49_RS16190	COG1114	Component of the transport system for branched-chain amino acids
ETK49_RS16195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ETK49_RS16200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETK49_RS16205	COG1309	transcriptional regulator
ETK49_RS16210	COG1956	GAF domain-containing protein
ETK49_RS16215	COG2203	Gaf domain
ETK49_RS16215	COG2199	diguanylate cyclase activity
ETK49_RS16220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ETK49_RS16235	COG3152	Membrane
ETK49_RS16240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ETK49_RS16245	COG1522	sequence-specific DNA binding
ETK49_RS16250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ETK49_RS16255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETK49_RS16260	COG0454	-acetyltransferase
ETK49_RS16265	COG0517	IMP dehydrogenase activity
ETK49_RS16270	COG0123	including yeast histone deacetylase and acetoin utilization protein
ETK49_RS16275	COG1360	Flagellar Motor Protein
ETK49_RS16280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ETK49_RS16285	COG1609	Transcriptional regulator
ETK49_RS16290	COG1605	Chorismate mutase
ETK49_RS16290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ETK49_RS16300	COG3118	belongs to the thioredoxin family
ETK49_RS16305	COG4980	gas vesicle protein
ETK49_RS16310	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ETK49_RS16315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ETK49_RS16320	COG1674	ftsk spoiiie
ETK49_RS16325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK49_RS16330	COG4848	Belongs to the UPF0354 family
ETK49_RS16335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS16345	COG1363	Peptidase, m42
ETK49_RS16350	COG5584	Small secreted protein
ETK49_RS16355	COG0281	malic enzyme
ETK49_RS16360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK49_RS16365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ETK49_RS16375	COG0510	thiamine kinase activity
ETK49_RS16380	COG1523	belongs to the glycosyl hydrolase 13 family
ETK49_RS16385	COG1597	lipid kinase activity
ETK49_RS16395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ETK49_RS16400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK49_RS16415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK49_RS16420	COG2252	PERMEase
ETK49_RS16425	COG1349	DNA-binding transcription factor activity
ETK49_RS16430	COG1187	pseudouridine synthase activity
ETK49_RS16435	COG2244	polysaccharide biosynthetic process
ETK49_RS16440	COG2081	HI0933 family
ETK49_RS16445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ETK49_RS16455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK49_RS16470	COG5578	integral membrane protein
ETK49_RS16475	COG0673	inositol 2-dehydrogenase activity
ETK49_RS16480	COG1653	transport
ETK49_RS16485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ETK49_RS16490	COG4209	transmembrane transport
ETK49_RS16495	COG2207	Transcriptional regulator
ETK49_RS16500	COG1653	transport
ETK49_RS16505	COG0395	ABC-type sugar transport system, permease component
ETK49_RS16510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK49_RS16515	COG1073	alpha beta
ETK49_RS16525	COG0583	DNA-binding transcription factor activity
ETK49_RS16530	COG0346	lactoylglutathione lyase activity
ETK49_RS16535	COG0495	leucyl-tRNA aminoacylation
ETK49_RS16545	COG2814	Major facilitator Superfamily
ETK49_RS16555	COG2433	Pfam Transposase IS66
ETK49_RS16560	COG0577	efflux transmembrane transporter activity
ETK49_RS16565	COG1136	(ABC) transporter
ETK49_RS16575	COG1131	(ABC) transporter
ETK49_RS16580	COG1725	Transcriptional regulator
ETK49_RS16590	COG1242	4 iron, 4 sulfur cluster binding
ETK49_RS16595	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ETK49_RS16600	COG1301	dicarboxylic acid transport
ETK49_RS16610	COG2267	carboxylic ester hydrolase activity
ETK49_RS16615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ETK49_RS16620	COG0671	phosphoesterase, PA-phosphatase related
ETK49_RS16625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK49_RS16625	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS16630	COG0367	asparagine synthase
ETK49_RS16635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ETK49_RS16640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ETK49_RS16655	COG1506	peptidase
ETK49_RS16660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ETK49_RS16665	COG1116	anion transmembrane transporter activity
ETK49_RS16670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ETK49_RS16675	COG0494	nUDIX hydrolase
ETK49_RS16685	COG4824	toxin secretion phage lysis holin
ETK49_RS16690	COG0783	Belongs to the Dps family
ETK49_RS16705	COG1854	S-ribosylhomocysteine lyase activity
ETK49_RS16710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ETK49_RS16715	COG0288	reversible hydration of carbon dioxide
ETK49_RS16720	COG0523	cobalamin synthesis protein
ETK49_RS16725	COG0803	Belongs to the bacterial solute-binding protein 9 family
ETK49_RS16730	COG0254	rRNA binding
ETK49_RS16735	COG1271	oxidase subunit
ETK49_RS16740	COG1294	oxidase, subunit
ETK49_RS16755	COG4948	Mandelate Racemase Muconate Lactonizing
ETK49_RS16760	COG0318	PFAM AMP-dependent synthetase and ligase
ETK49_RS16765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ETK49_RS16770	COG0596	Alpha beta hydrolase
ETK49_RS16775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ETK49_RS16780	COG1169	isochorismate synthase
ETK49_RS16785	COG1575	Belongs to the MenA family. Type 1 subfamily
ETK49_RS16790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK49_RS16795	COG0058	SHG alpha-glucan phosphorylase activity
ETK49_RS16800	COG0297	glycogen (starch) synthase activity
ETK49_RS16805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ETK49_RS16810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ETK49_RS16940	COG1609	Transcriptional regulator
ETK49_RS16945	COG3859	Proton-coupled thiamine transporter YuaJ
ETK49_RS16950	COG3764	Sortase (surface protein transpeptidase)
ETK49_RS16965	COG0457	Tetratricopeptide repeat
ETK49_RS16970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ETK49_RS16975	COG0569	domain protein
ETK49_RS16980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETK49_RS16990	COG2318	DinB family
ETK49_RS17000	COG1454	alcohol dehydrogenase
ETK49_RS17005	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS17010	COG1510	regulation of RNA biosynthetic process
ETK49_RS17020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ETK49_RS17025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ETK49_RS17030	COG2140	Oxalate decarboxylase
ETK49_RS17075	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ETK49_RS17085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK49_RS17090	COG0726	polysaccharide deacetylase
ETK49_RS17095	COG1408	metallophosphoesterase
ETK49_RS17100	COG1968	undecaprenyl-diphosphatase activity
ETK49_RS17105	COG0628	permease
ETK49_RS17110	COG0673	inositol 2-dehydrogenase activity
ETK49_RS17115	COG0693	protein deglycase activity
ETK49_RS17120	COG0840	transmembrane signaling receptor activity
ETK49_RS17125	COG0840	transmembrane signaling receptor activity
ETK49_RS17130	COG0840	transmembrane signaling receptor activity
ETK49_RS17140	COG2070	2-Nitropropane dioxygenase
ETK49_RS17145	COG0432	Pfam Uncharacterised protein family UPF0047
ETK49_RS17150	COG0366	Alpha amylase catalytic
ETK49_RS17165	COG5297	Belongs to the glycosyl hydrolase family 6
ETK49_RS17170	COG1253	flavin adenine dinucleotide binding
ETK49_RS17175	COG2738	Putative neutral zinc metallopeptidase
ETK49_RS17190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ETK49_RS17205	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ETK49_RS17215	COG0166	Belongs to the GPI family
ETK49_RS17220	COG1979	alcohol dehydrogenase
ETK49_RS17225	COG2155	Conserved Protein
ETK49_RS17230	COG1098	S1 RNA binding domain
ETK49_RS17235	COG0436	Aminotransferase
ETK49_RS17240	COG1522	sequence-specific DNA binding
ETK49_RS17245	COG2267	carboxylic ester hydrolase activity
ETK49_RS17260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ETK49_RS17275	COG5018	Exonuclease
ETK49_RS17280	COG2814	Major facilitator Superfamily
ETK49_RS17285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK49_RS17290	COG3011	Protein conserved in bacteria
ETK49_RS17300	COG3290	protein histidine kinase activity
ETK49_RS17305	COG4565	transcriptional regulatory protein
ETK49_RS17315	COG1183	phosphatidylcholine synthase activity
ETK49_RS17320	COG0586	Pfam SNARE associated Golgi protein
ETK49_RS17325	COG0688	phosphatidylethanolamine metabolic process
ETK49_RS17330	COG3493	citrate carrier protein
ETK49_RS17340	COG2111	Na H antiporter
ETK49_RS17340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETK49_RS17345	COG2111	Na H antiporter
ETK49_RS17350	COG1006	Multisubunit Na H antiporter MnhC subunit
ETK49_RS17355	COG0651	ATP synthesis coupled electron transport
ETK49_RS17360	COG1863	multisubunit Na H antiporter MnhE subunit
ETK49_RS17365	COG2212	antiporter activity
ETK49_RS17370	COG1320	monovalent cation:proton antiporter activity
ETK49_RS17375	COG2050	protein possibly involved in aromatic compounds catabolism
ETK49_RS17380	COG2197	response regulator
ETK49_RS17385	COG4585	Histidine kinase
ETK49_RS17395	COG0142	geranyltranstransferase activity
ETK49_RS17415	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ETK49_RS17420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ETK49_RS17425	COG1335	isochorismatase
ETK49_RS17430	COG5506	Protein of unknown function (DUF1694)
ETK49_RS17445	COG0628	permease
ETK49_RS17450	COG1959	2 iron, 2 sulfur cluster binding
ETK49_RS17455	COG0657	acetylesterase activity
ETK49_RS17465	COG1418	mRNA catabolic process
ETK49_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS17480	COG1511	domain protein
ETK49_RS17485	COG1674	ftsk spoiiie
ETK49_RS17485	COG0433	COG0433 Predicted ATPase
ETK49_RS17490	COG4499	WXG100 protein secretion system (Wss), protein YukC
ETK49_RS17495	COG5417	Belongs to the EsaB family
ETK49_RS17500	COG4842	Belongs to the WXG100 family
ETK49_RS17505	COG1115	amino acid carrier protein
ETK49_RS17510	COG2508	Transcriptional regulator
ETK49_RS17510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ETK49_RS17515	COG0686	Belongs to the AlaDH PNT family
ETK49_RS17525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ETK49_RS17530	COG1268	BioY protein
ETK49_RS17535	COG2056	Na+-H+ antiporter family
ETK49_RS17540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ETK49_RS17545	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ETK49_RS17550	COG3584	3D domain protein
ETK49_RS17560	COG1252	NADH dehydrogenase
ETK49_RS17565	COG0492	ferredoxin-NADP+ reductase activity
ETK49_RS17580	COG0456	acetyltransferase
ETK49_RS17585	COG0316	Belongs to the HesB IscA family
ETK49_RS17590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ETK49_RS17595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK49_RS17600	COG4844	belongs to the
ETK49_RS17605	COG1252	NADH dehydrogenase
ETK49_RS17610	COG5646	InterPro IPR014922
ETK49_RS17620	COG0457	Tetratricopeptide repeat
ETK49_RS17625	COG3479	Phenolic acid decarboxylase
ETK49_RS17635	COG4837	Protein of unknown function (DUF1462)
ETK49_RS17640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ETK49_RS17645	COG1506	peptidase
ETK49_RS17645	COG0823	Involved in the tonB-independent uptake of proteins
ETK49_RS17645	COG4946	Tricorn protease homolog
ETK49_RS17650	COG0083	homoserine kinase activity
ETK49_RS17655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ETK49_RS17660	COG0460	homoserine dehydrogenase
ETK49_RS17670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK49_RS17675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ETK49_RS17680	COG0647	UMP catabolic process
ETK49_RS17685	COG2445	Protein of unknown function DUF86
ETK49_RS17690	COG4470	Protein conserved in bacteria
ETK49_RS17705	COG0739	heme binding
ETK49_RS17715	COG0733	neurotransmitter:sodium symporter activity
ETK49_RS17725	COG3377	Domain of unknown function (DUF1805)
ETK49_RS17730	COG0737	Belongs to the 5'-nucleotidase family
ETK49_RS17735	COG0730	response to heat
ETK49_RS17740	COG1801	Protein of unknown function DUF72
ETK49_RS17750	COG3226	Transcriptional regulator
ETK49_RS17760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ETK49_RS17765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK49_RS17770	COG2508	Transcriptional regulator
ETK49_RS17775	COG2814	Major facilitator Superfamily
ETK49_RS17780	COG1288	antiporter activity
ETK49_RS17785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETK49_RS17790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETK49_RS17795	COG2356	endonuclease I
ETK49_RS17805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ETK49_RS17820	COG0457	Tetratricopeptide repeat
ETK49_RS17825	COG0719	Fe-S assembly protein
ETK49_RS17830	COG0822	iron-sulfur transferase activity
ETK49_RS17835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ETK49_RS17840	COG0719	Fe-S assembly protein
ETK49_RS17845	COG0396	ATPase activity
ETK49_RS17855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ETK49_RS17860	COG1464	Belongs to the NlpA lipoprotein family
ETK49_RS17865	COG2011	ABC-type metal ion transport system permease component
ETK49_RS17870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ETK49_RS17880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK49_RS17885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ETK49_RS17895	COG0509	glycine decarboxylation via glycine cleavage system
ETK49_RS17900	COG1393	Belongs to the ArsC family
ETK49_RS17905	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS17910	COG0183	Belongs to the thiolase family
ETK49_RS17915	COG1250	3-hydroxyacyl-CoA dehydrogenase
ETK49_RS17915	COG1024	Enoyl-CoA hydratase
ETK49_RS17930	COG5577	PFAM Coat F domain
ETK49_RS17945	COG1120	ATPase activity
ETK49_RS17950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS17955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS17960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS17975	COG1686	Belongs to the peptidase S11 family
ETK49_RS17980	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS17985	COG0783	Belongs to the Dps family
ETK49_RS17990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK49_RS17995	COG0745	RESPONSE REGULATOR receiver
ETK49_RS18000	COG2770	Histidine kinase
ETK49_RS18000	COG2205	protein histidine kinase activity
ETK49_RS18005	COG1309	transcriptional regulator
ETK49_RS18010	COG0114	fumarate hydratase activity
ETK49_RS18020	COG0697	spore germination
ETK49_RS18025	COG0814	amino acid
ETK49_RS18040	COG2197	response regulator
ETK49_RS18045	COG4585	Histidine kinase
ETK49_RS18050	COG4758	membrane
ETK49_RS18060	COG1842	Phage shock protein A
ETK49_RS18065	COG4758	membrane
ETK49_RS18070	COG4677	pectinesterase activity
ETK49_RS18075	COG2096	Adenosyltransferase
ETK49_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS18090	COG1454	alcohol dehydrogenase
ETK49_RS18095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETK49_RS18100	COG1120	ATPase activity
ETK49_RS18105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS18110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS18115	COG1802	Transcriptional regulator
ETK49_RS18120	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS18125	COG2258	MOSC domain
ETK49_RS18130	COG0583	DNA-binding transcription factor activity
ETK49_RS18140	COG2721	sulfolactate sulfo-lyase activity
ETK49_RS18145	COG0246	Mannitol dehydrogenase
ETK49_RS18150	COG1609	Transcriptional regulator
ETK49_RS18155	COG2211	Major facilitator Superfamily
ETK49_RS18160	COG1904	glucuronate isomerase
ETK49_RS18165	COG2205	protein histidine kinase activity
ETK49_RS18170	COG0745	RESPONSE REGULATOR receiver
ETK49_RS18175	COG1120	ATPase activity
ETK49_RS18180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS18185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS18190	COG0531	amino acid
ETK49_RS18200	COG1988	membrane-bound metal-dependent
ETK49_RS18205	COG1368	sulfuric ester hydrolase activity
ETK49_RS18210	COG2814	Major facilitator Superfamily
ETK49_RS18215	COG0656	L-ascorbic acid biosynthetic process
ETK49_RS18220	COG1940	carbohydrate kinase activity
ETK49_RS18225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ETK49_RS18235	COG3973	AAA domain
ETK49_RS18240	COG2860	membrane
ETK49_RS18245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ETK49_RS18245	COG0456	acetyltransferase
ETK49_RS18250	COG0456	acetyltransferase
ETK49_RS18255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ETK49_RS18260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ETK49_RS18265	COG2217	Heavy metal translocating P-type atpase
ETK49_RS18275	COG1175	transmembrane transport
ETK49_RS18280	COG0395	ABC-type sugar transport system, permease component
ETK49_RS18285	COG1501	Belongs to the glycosyl hydrolase 31 family
ETK49_RS18290	COG1472	Belongs to the glycosyl hydrolase 3 family
ETK49_RS18295	COG1121	(ABC) transporter
ETK49_RS18300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETK49_RS18305	COG0803	Belongs to the bacterial solute-binding protein 9 family
ETK49_RS18320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ETK49_RS18320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ETK49_RS18325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS18325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS18325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK49_RS18340	COG2217	Heavy metal translocating P-type atpase
ETK49_RS18345	COG2608	mercury ion transmembrane transporter activity
ETK49_RS18350	COG1937	Protein conserved in bacteria
ETK49_RS18355	COG0693	protein deglycase activity
ETK49_RS18360	COG1349	DNA-binding transcription factor activity
ETK49_RS18365	COG1070	Carbohydrate kinase
ETK49_RS18370	COG4952	isomerase
ETK49_RS18380	COG3347	Dehydrogenase
ETK49_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS18385	COG2814	Major facilitator Superfamily
ETK49_RS18390	COG2814	Major facilitator Superfamily
ETK49_RS18400	COG2124	cytochrome p450
ETK49_RS18410	COG1846	Transcriptional regulator
ETK49_RS18420	COG0673	inositol 2-dehydrogenase activity
ETK49_RS18425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ETK49_RS18430	COG1054	Belongs to the UPF0176 family
ETK49_RS18440	COG1191	sigma factor activity
ETK49_RS18450	COG2140	Oxalate decarboxylase
ETK49_RS18490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ETK49_RS18505	COG0457	Tetratricopeptide repeat
ETK49_RS18510	COG5444	nuclease activity
ETK49_RS18550	COG5434	Belongs to the glycosyl hydrolase 28 family
ETK49_RS18555	COG1705	Flagellar rod assembly protein muramidase FlgJ
ETK49_RS18565	COG5280	Phage tail tape measure protein TP901
ETK49_RS18565	COG3953	SLT domain
ETK49_RS18625	COG1802	Transcriptional regulator
ETK49_RS18625	COG4626	Terminase
ETK49_RS18785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ETK49_RS18790	COG0557	exoribonuclease II activity
ETK49_RS18795	COG1647	Serine aminopeptidase, S33
ETK49_RS18800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ETK49_RS18805	COG2002	toxin-antitoxin pair type II binding
ETK49_RS18810	COG1476	TRANSCRIPTIONal
ETK49_RS18815	COG1396	sequence-specific DNA binding
ETK49_RS18820	COG1396	sequence-specific DNA binding
ETK49_RS18825	COG1174	glycine betaine transport
ETK49_RS18830	COG1732	Glycine betaine
ETK49_RS18835	COG1174	glycine betaine transport
ETK49_RS18840	COG0517	IMP dehydrogenase activity
ETK49_RS18840	COG1125	glycine betaine transport
ETK49_RS18845	COG1510	regulation of RNA biosynthetic process
ETK49_RS18850	COG2095	MarC family integral membrane protein
ETK49_RS18865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS18880	COG0693	protein deglycase activity
ETK49_RS18885	COG0148	phosphopyruvate hydratase activity
ETK49_RS18890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ETK49_RS18895	COG0149	triose-phosphate isomerase activity
ETK49_RS18900	COG0126	phosphoglycerate kinase activity
ETK49_RS18910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ETK49_RS18915	COG2390	Transcriptional regulator
ETK49_RS18920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK49_RS18925	COG1113	amino acid transport
ETK49_RS18945	COG1556	Lactate utilization protein
ETK49_RS18950	COG1139	Iron-sulfur cluster binding protein
ETK49_RS18955	COG0247	lactate metabolic process
ETK49_RS18960	COG2186	Transcriptional regulator
ETK49_RS18965	COG1620	l-lactate permease
ETK49_RS18970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ETK49_RS18980	COG5039	Polysaccharide pyruvyl transferase
ETK49_RS18985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK49_RS18990	COG0110	maltose O-acetyltransferase activity
ETK49_RS18995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ETK49_RS19000	COG2244	polysaccharide biosynthetic process
ETK49_RS19005	COG1216	Glycosyl transferase, family 2
ETK49_RS19010	COG5039	Polysaccharide pyruvyl transferase
ETK49_RS19015	COG1216	Glycosyl transferase, family 2
ETK49_RS19025	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS19030	COG1215	transferase activity, transferring glycosyl groups
ETK49_RS19035	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS19040	COG1086	Polysaccharide biosynthesis protein
ETK49_RS19045	COG0489	protein tyrosine kinase activity
ETK49_RS19050	COG3944	biosynthesis protein
ETK49_RS19055	COG1396	sequence-specific DNA binding
ETK49_RS19060	COG2249	NAD(P)H dehydrogenase (quinone) activity
ETK49_RS19065	COG2271	Major facilitator Superfamily
ETK49_RS19075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ETK49_RS19090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETK49_RS19100	COG1733	regulation of RNA biosynthetic process
ETK49_RS19105	COG1902	pentaerythritol trinitrate reductase activity
ETK49_RS19110	COG1621	beta-fructofuranosidase activity
ETK49_RS19115	COG1621	beta-fructofuranosidase activity
ETK49_RS19130	COG0740	serine-type endopeptidase activity
ETK49_RS19145	COG1611	Belongs to the LOG family
ETK49_RS19150	COG1694	Mazg nucleotide pyrophosphohydrolase
ETK49_RS19155	COG1078	dGTPase activity
ETK49_RS19160	COG0659	secondary active sulfate transmembrane transporter activity
ETK49_RS19165	COG0288	reversible hydration of carbon dioxide
ETK49_RS19170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETK49_RS19175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ETK49_RS19180	COG0640	Transcriptional regulator
ETK49_RS19190	COG2732	(Barnase) inhibitor
ETK49_RS19195	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ETK49_RS19200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS19205	COG1481	regulation of sporulation
ETK49_RS19210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ETK49_RS19215	COG1660	Displays ATPase and GTPase activities
ETK49_RS19220	COG1051	belongs to the nudix hydrolase family
ETK49_RS19230	COG0492	ferredoxin-NADP+ reductase activity
ETK49_RS19235	COG0457	Tetratricopeptide repeat
ETK49_RS19240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK49_RS19245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ETK49_RS19245	COG0140	phosphoribosyl-ATP diphosphatase activity
ETK49_RS19250	COG0107	imidazoleglycerol-phosphate synthase activity
ETK49_RS19255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ETK49_RS19260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ETK49_RS19265	COG0131	Imidazoleglycerol-phosphate dehydratase
ETK49_RS19270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ETK49_RS19275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ETK49_RS19280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ETK49_RS19285	COG4990	cell redox homeostasis
ETK49_RS19290	COG5297	Belongs to the glycosyl hydrolase family 6
ETK49_RS19295	COG0110	maltose O-acetyltransferase activity
ETK49_RS19300	COG0546	phosphoglycolate phosphatase activity
ETK49_RS19305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ETK49_RS19310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ETK49_RS19315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ETK49_RS19320	COG1846	Transcriptional regulator
ETK49_RS19325	COG2814	Major facilitator Superfamily
ETK49_RS19330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ETK49_RS19335	COG1950	PFAM Membrane protein of
ETK49_RS19340	COG1983	PspC domain protein
ETK49_RS19345	COG3595	metallopeptidase activity
ETK49_RS19365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ETK49_RS19370	COG0556	nucleotide-excision repair
ETK49_RS19375	COG4897	Protein conserved in bacteria
ETK49_RS19385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK49_RS19395	COG3409	Peptidoglycan-binding domain 1 protein
ETK49_RS19395	COG0793	Belongs to the peptidase S41A family
ETK49_RS19400	COG0473	3-isopropylmalate dehydrogenase activity
ETK49_RS19405	COG0791	NLP P60 protein
ETK49_RS19405	COG3883	PFAM NLP P60 protein
ETK49_RS19410	COG2177	Part of the ABC transporter FtsEX involved in
ETK49_RS19415	COG2884	Cell division ATP-binding protein ftsE
ETK49_RS19425	COG2010	Cytochrome c
ETK49_RS19430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS19440	COG0653	protein targeting
ETK49_RS19445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ETK49_RS19460	COG1516	flagellar protein fliS
ETK49_RS19465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ETK49_RS19470	COG1334	flagellar protein FlaG
ETK49_RS19475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETK49_RS19480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ETK49_RS19485	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ETK49_RS19495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETK49_RS19500	COG4786	Flagellar basal body rod
ETK49_RS19500	COG1256	bacterial-type flagellum assembly
ETK49_RS19505	COG3418	PFAM FlgN family protein
ETK49_RS19510	COG2747	anti-sigma28 factor FlgM
ETK49_RS19520	COG1040	competence protein
ETK49_RS19530	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ETK49_RS19535	COG1307	EDD domain protein, DegV family
ETK49_RS19540	COG2197	response regulator
ETK49_RS19545	COG4585	Histidine kinase
ETK49_RS19550	COG1739	Uncharacterized protein family UPF0029
ETK49_RS19555	COG1316	TRANSCRIPTIONal
ETK49_RS19565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ETK49_RS19570	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS19575	COG1215	transferase activity, transferring glycosyl groups
ETK49_RS19580	COG3206	protein involved in exopolysaccharide biosynthesis
ETK49_RS19585	COG3307	-O-antigen
ETK49_RS19590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK49_RS19595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ETK49_RS19600	COG0438	transferase activity, transferring glycosyl groups
ETK49_RS19600	COG0297	glycogen (starch) synthase activity
ETK49_RS19605	COG2244	polysaccharide biosynthetic process
ETK49_RS19615	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK49_RS19615	COG2247	cell wall binding repeat
ETK49_RS19620	COG2247	cell wall binding repeat
ETK49_RS19620	COG2385	sporulation resulting in formation of a cellular spore
ETK49_RS19630	COG1316	TRANSCRIPTIONal
ETK49_RS19640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ETK49_RS19645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ETK49_RS19650	COG1134	teichoic acid transport
ETK49_RS19655	COG1682	transport, permease protein
ETK49_RS19670	COG0463	Glycosyl transferase, family 2
ETK49_RS19670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ETK49_RS19675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ETK49_RS19680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ETK49_RS19685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ETK49_RS19690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ETK49_RS19695	COG4193	domain, Protein
ETK49_RS19700	COG1482	cell wall glycoprotein biosynthetic process
ETK49_RS19720	COG0800	Aldolase
ETK49_RS19725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK49_RS19730	COG1609	Transcriptional regulator
ETK49_RS19735	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ETK49_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS19745	COG1063	alcohol dehydrogenase
ETK49_RS19755	COG1316	TRANSCRIPTIONal
ETK49_RS19760	COG0561	phosphatase activity
ETK49_RS19765	COG0791	NLP P60 protein
ETK49_RS19770	COG2843	Capsule synthesis protein
ETK49_RS19780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ETK49_RS19785	COG1609	Transcriptional regulator
ETK49_RS19790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK49_RS19795	COG1869	D-ribose catabolic process
ETK49_RS19800	COG1129	ABC transporter
ETK49_RS19805	COG1172	Belongs to the binding-protein-dependent transport system permease family
ETK49_RS19810	COG1879	ABC-type sugar transport system periplasmic component
ETK49_RS19820	COG3527	Alpha-acetolactate decarboxylase
ETK49_RS19825	COG0028	Belongs to the TPP enzyme family
ETK49_RS19830	COG0583	DNA-binding transcription factor activity
ETK49_RS19835	COG0405	Gamma-glutamyltransferase
ETK49_RS19840	COG1522	sequence-specific DNA binding
ETK49_RS19845	COG2059	Chromate
ETK49_RS19850	COG2059	Chromate
ETK49_RS19855	COG4464	protein tyrosine phosphatase activity
ETK49_RS19860	COG3944	biosynthesis protein
ETK49_RS19870	COG4715	Zinc finger, swim domain protein
ETK49_RS19875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ETK49_RS19880	COG0561	phosphatase activity
ETK49_RS19885	COG1349	DNA-binding transcription factor activity
ETK49_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS19905	COG3732	PTS system glucitol sorbitol-specific
ETK49_RS19925	COG0629	single-stranded DNA binding
ETK49_RS19940	COG1970	mechanosensitive ion channel activity
ETK49_RS19945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETK49_RS19950	COG4786	Flagellar basal body rod
ETK49_RS19955	COG4786	Flagellar basal body rod
ETK49_RS19960	COG1077	Cell shape determining protein MreB Mrl
ETK49_RS19965	COG1609	Transcriptional regulator
ETK49_RS19975	COG1846	Transcriptional regulator
ETK49_RS19980	COG2814	Major facilitator Superfamily
ETK49_RS19985	COG0671	phosphoesterase, PA-phosphatase related
ETK49_RS19990	COG1227	inorganic diphosphatase activity
ETK49_RS19995	COG3546	catalase activity
ETK49_RS20000	COG3361	conserved protein (COG2071)
ETK49_RS20005	COG0517	IMP dehydrogenase activity
ETK49_RS20010	COG0598	Magnesium transport protein CorA
ETK49_RS20015	COG1253	flavin adenine dinucleotide binding
ETK49_RS20020	COG0004	ammonium transporteR
ETK49_RS20025	COG0347	Belongs to the P(II) protein family
ETK49_RS20030	COG0740	serine-type endopeptidase activity
ETK49_RS20040	COG0739	heme binding
ETK49_RS20045	COG1247	-acetyltransferase
ETK49_RS20055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK49_RS20060	COG0477	Major facilitator Superfamily
ETK49_RS20065	COG3251	PFAM MbtH domain protein
ETK49_RS20070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK49_RS20075	COG3433	isochorismatase activity
ETK49_RS20075	COG1535	isochorismatase
ETK49_RS20080	COG1021	2,3-dihydroxybenzoate-AMP ligase
ETK49_RS20085	COG1169	isochorismate synthase
ETK49_RS20090	COG1028	Short-chain dehydrogenase reductase Sdr
ETK49_RS20095	COG2819	hydrolase of the alpha beta superfamily
ETK49_RS20100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS20105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK49_RS20110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS20115	COG2207	Transcriptional regulator
ETK49_RS20115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS20125	COG2910	NAD(P)H-binding
ETK49_RS20130	COG1959	2 iron, 2 sulfur cluster binding
ETK49_RS20140	COG1994	Peptidase M50
ETK49_RS20145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ETK49_RS20150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ETK49_RS20155	COG2223	nitrite transmembrane transporter activity
ETK49_RS20160	COG3383	formate dehydrogenase (NAD+) activity
ETK49_RS20165	COG2304	oxidoreductase activity
ETK49_RS20170	COG2304	oxidoreductase activity
ETK49_RS20175	COG2385	sporulation resulting in formation of a cellular spore
ETK49_RS20180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ETK49_RS20190	COG4836	Membrane
ETK49_RS20195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ETK49_RS20200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ETK49_RS20205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ETK49_RS20210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ETK49_RS20215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ETK49_RS20220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ETK49_RS20225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ETK49_RS20245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ETK49_RS20250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ETK49_RS20255	COG4475	Protein of unknown function (DUF436)
ETK49_RS20260	COG0698	ribose 5-phosphate isomerase
ETK49_RS20265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK49_RS20270	COG1971	Probably functions as a manganese efflux pump
ETK49_RS20275	COG0009	L-threonylcarbamoyladenylate synthase
ETK49_RS20280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ETK49_RS20290	COG0738	Major facilitator superfamily
ETK49_RS20295	COG0673	inositol 2-dehydrogenase activity
ETK49_RS20300	COG0561	phosphatase activity
ETK49_RS20305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK49_RS20310	COG1609	Transcriptional regulator
ETK49_RS20315	COG2890	protein-(glutamine-N5) methyltransferase activity
ETK49_RS20320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ETK49_RS20325	COG0346	lactoylglutathione lyase activity
ETK49_RS20330	COG0789	Transcriptional regulator
ETK49_RS20335	COG0679	Auxin Efflux Carrier
ETK49_RS20340	COG0281	malic enzyme
ETK49_RS20345	COG1435	thymidine kinase activity
ETK49_RS20350	COG0254	rRNA binding
ETK49_RS20355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ETK49_RS20360	COG1494	fructose-1,6-bisphosphatase
ETK49_RS20365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ETK49_RS20370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ETK49_RS20375	COG0191	fructose-bisphosphate aldolase activity
ETK49_RS20380	COG2204	response regulator
ETK49_RS20385	COG4821	SIS domain
ETK49_RS20395	COG0504	CTP synthase activity
ETK49_RS20400	COG3343	RNA polymerase activity
ETK49_RS20405	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS20410	COG1960	acyl-CoA dehydrogenase activity
ETK49_RS20415	COG1250	3-hydroxyacyl-CoA dehydrogenase
ETK49_RS20420	COG0183	Belongs to the thiolase family
ETK49_RS20425	COG0247	lactate metabolic process
ETK49_RS20425	COG2181	nitrate reductase activity
ETK49_RS20430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK49_RS20440	COG0018	arginyl-trna synthetase
ETK49_RS20445	COG4506	Protein conserved in bacteria
ETK49_RS20450	COG0010	Belongs to the arginase family
ETK49_RS20455	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ETK49_RS20470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK49_RS20480	COG1994	Peptidase M50
ETK49_RS20485	COG1942	4-Oxalocrotonate Tautomerase
ETK49_RS20495	COG3465	dGTPase activity
ETK49_RS20500	COG1078	dGTPase activity
ETK49_RS20505	COG4844	belongs to the
ETK49_RS20530	COG2814	Major facilitator Superfamily
ETK49_RS20555	COG1414	Transcriptional regulator
ETK49_RS20565	COG0280	phosphate acetyltransferase
ETK49_RS20570	COG3253	May function as heme-dependent peroxidase
ETK49_RS20585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETK49_RS20605	COG1131	(ABC) transporter
ETK49_RS20620	COG2363	Small membrane protein
ETK49_RS20625	COG2233	PERMEase
ETK49_RS20635	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS20640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ETK49_RS20645	COG1216	Glycosyl transferase, family 2
ETK49_RS20650	COG0351	phosphomethylpyrimidine kinase
ETK49_RS20660	COG1621	beta-fructofuranosidase activity
ETK49_RS20665	COG1263	PTS System
ETK49_RS20665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS20670	COG3711	transcriptional antiterminator
ETK49_RS20680	COG1404	Belongs to the peptidase S8 family
ETK49_RS20690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK49_RS20695	COG0778	Nitroreductase
ETK49_RS20700	COG1473	amidohydrolase
ETK49_RS20705	COG0772	Belongs to the SEDS family
ETK49_RS20710	COG0772	Belongs to the SEDS family
ETK49_RS20715	COG3314	Sporulation integral membrane protein YlbJ
ETK49_RS20735	COG0456	acetyltransferase
ETK49_RS20770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ETK49_RS20780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ETK49_RS20785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ETK49_RS20790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETK49_RS20810	COG3162	membrane
ETK49_RS20815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS20820	COG1070	Carbohydrate kinase
ETK49_RS20825	COG2115	Belongs to the xylose isomerase family
ETK49_RS20835	COG0352	thiamine-phosphate diphosphorylase activity
ETK49_RS20840	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ETK49_RS20845	COG0583	DNA-binding transcription factor activity
ETK49_RS20860	COG1380	Effector of murein hydrolase LrgA
ETK49_RS20865	COG1346	cytolysis
ETK49_RS20875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK49_RS20880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ETK49_RS20885	COG0346	lactoylglutathione lyase activity
ETK49_RS20890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETK49_RS20895	COG1442	glycosyl transferase family 8
ETK49_RS20905	COG4585	Histidine kinase
ETK49_RS20910	COG2197	response regulator
ETK49_RS20915	COG2409	Drug exporters of the RND superfamily
ETK49_RS20920	COG5522	Integral membrane protein (intg_mem_TP0381)
ETK49_RS20925	COG2271	Major facilitator Superfamily
ETK49_RS20930	COG4948	Mandelate Racemase Muconate Lactonizing
ETK49_RS20935	COG0800	Aldolase
ETK49_RS20940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK49_RS20950	COG2234	aminopeptidase activity
ETK49_RS20955	COG0477	Major facilitator Superfamily
ETK49_RS20965	COG2357	RelA SpoT domain protein
ETK49_RS20980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK49_RS20985	COG1696	Membrane protein involved in D-alanine export
ETK49_RS20990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ETK49_RS20995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ETK49_RS21000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK49_RS21005	COG2814	Major facilitator Superfamily
ETK49_RS21010	COG1486	melibiose metabolic process
ETK49_RS21015	COG1447	Phosphotransferase system cellobiose-specific component IIA
ETK49_RS21020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS21025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS21030	COG3711	transcriptional antiterminator
ETK49_RS21030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK49_RS21035	COG2094	Belongs to the DNA glycosylase MPG family
ETK49_RS21045	COG0372	Belongs to the citrate synthase family
ETK49_RS21050	COG2079	MmgE PrpD family protein
ETK49_RS21055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ETK49_RS21070	COG1132	(ABC) transporter
ETK49_RS21075	COG2755	lipolytic protein G-D-S-L family
ETK49_RS21090	COG2814	Major facilitator Superfamily
ETK49_RS21095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK49_RS21100	COG1131	(ABC) transporter
ETK49_RS21120	COG1595	DNA-templated transcription, initiation
ETK49_RS21125	COG2814	Major facilitator Superfamily
ETK49_RS21130	COG0753	catalase activity
ETK49_RS21135	COG0753	catalase activity
ETK49_RS21140	COG0735	belongs to the Fur family
ETK49_RS21145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ETK49_RS21150	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK49_RS21155	COG1131	(ABC) transporter
ETK49_RS21170	COG1131	(ABC) transporter
ETK49_RS21225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ETK49_RS21230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ETK49_RS21235	COG4988	ABC transporter
ETK49_RS21240	COG1294	oxidase, subunit
ETK49_RS21245	COG1271	oxidase subunit
ETK49_RS21255	COG2116	formate transmembrane transporter activity
ETK49_RS21265	COG0281	malic enzyme
ETK49_RS21270	COG1757	Na H antiporter
ETK49_RS21275	COG1027	Aspartate ammonia-lyase
ETK49_RS21280	COG0252	asparaginase activity
ETK49_RS21285	COG1396	sequence-specific DNA binding
ETK49_RS21290	COG2706	6-phosphogluconolactonase activity
ETK49_RS21295	COG0745	RESPONSE REGULATOR receiver
ETK49_RS21300	COG2205	protein histidine kinase activity
ETK49_RS21310	COG1136	(ABC) transporter
ETK49_RS21315	COG0577	efflux transmembrane transporter activity
ETK49_RS21320	COG5294	Protein conserved in bacteria
ETK49_RS21330	COG0726	polysaccharide deacetylase
ETK49_RS21335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK49_RS21345	COG1215	transferase activity, transferring glycosyl groups
ETK49_RS21355	COG3493	citrate carrier protein
ETK49_RS21360	COG0584	glycerophosphoryl diester phosphodiesterase
ETK49_RS21375	COG1368	sulfuric ester hydrolase activity
ETK49_RS21385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK49_RS21400	COG2235	arginine
ETK49_RS21405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ETK49_RS21415	COG0549	Belongs to the carbamate kinase family
ETK49_RS21425	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS21430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK49_RS21440	COG1595	DNA-templated transcription, initiation
ETK49_RS21450	COG2195	Cleaves the N-terminal amino acid of tripeptides
ETK49_RS21460	COG1621	beta-fructofuranosidase activity
ETK49_RS21465	COG2223	nitrite transmembrane transporter activity
ETK49_RS21470	COG1609	Transcriptional regulator
ETK49_RS21485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETK49_RS21490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ETK49_RS21495	COG0463	Glycosyl transferase, family 2
ETK49_RS21500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETK49_RS21525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK49_RS21530	COG0753	catalase activity
ETK49_RS21530	COG0693	protein deglycase activity
ETK49_RS21540	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS21545	COG2190	(PTS) system
ETK49_RS21545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS21545	COG1263	PTS System
ETK49_RS21550	COG3711	transcriptional antiterminator
ETK49_RS21555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ETK49_RS21560	COG1122	ATPase activity
ETK49_RS21565	COG4721	ABC-type cobalt transport system, permease component
ETK49_RS21570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ETK49_RS21575	COG2224	Isocitrate lyase
ETK49_RS21580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ETK49_RS21590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ETK49_RS21595	COG0577	efflux transmembrane transporter activity
ETK49_RS21600	COG1136	(ABC) transporter
ETK49_RS21605	COG2205	protein histidine kinase activity
ETK49_RS21610	COG0745	RESPONSE REGULATOR receiver
ETK49_RS21615	COG2723	6-phospho-beta-galactosidase activity
ETK49_RS21620	COG2190	(PTS) system
ETK49_RS21620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS21620	COG1263	PTS System
ETK49_RS21630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ETK49_RS21635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ETK49_RS21640	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK49_RS21645	COG0513	Belongs to the DEAD box helicase family
ETK49_RS21675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ETK49_RS21680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK49_RS21685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ETK49_RS21690	COG2390	Transcriptional regulator
ETK49_RS21700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ETK49_RS21705	COG3706	GGDEF domain
ETK49_RS21710	COG5298	Protein conserved in bacteria
ETK49_RS21715	COG1215	transferase activity, transferring glycosyl groups
ETK49_RS21725	COG3977	Valine--pyruvate aminotransferase
ETK49_RS21740	COG1181	Belongs to the D-alanine--D-alanine ligase family
ETK49_RS21750	COG0191	fructose-bisphosphate aldolase activity
ETK49_RS21755	COG1082	Xylose isomerase domain protein TIM barrel
ETK49_RS21760	COG1082	Xylose isomerase domain protein TIM barrel
ETK49_RS21765	COG0673	inositol 2-dehydrogenase activity
ETK49_RS21770	COG2814	Major facilitator Superfamily
ETK49_RS21775	COG1082	Xylose isomerase domain protein TIM barrel
ETK49_RS21780	COG3962	Belongs to the TPP enzyme family
ETK49_RS21785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK49_RS21790	COG3718	enzyme involved in inositol metabolism
ETK49_RS21795	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS21800	COG1349	DNA-binding transcription factor activity
ETK49_RS21805	COG0667	Aldo Keto reductase
ETK49_RS21815	COG2271	Major facilitator Superfamily
ETK49_RS21820	COG0326	Molecular chaperone. Has ATPase activity
ETK49_RS21825	COG0488	(ABC) transporter
ETK49_RS21830	COG0561	phosphatase activity
ETK49_RS21850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK49_RS21880	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ETK49_RS21885	COG0577	efflux transmembrane transporter activity
ETK49_RS21890	COG1136	(ABC) transporter
ETK49_RS21895	COG2205	protein histidine kinase activity
ETK49_RS21900	COG0745	RESPONSE REGULATOR receiver
ETK49_RS21910	COG0840	transmembrane signaling receptor activity
ETK49_RS21910	COG5278	phosphoserine phosphatase activity
ETK49_RS21915	COG1115	amino acid carrier protein
ETK49_RS21920	COG0686	Belongs to the AlaDH PNT family
ETK49_RS21925	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ETK49_RS21930	COG1874	Beta-galactosidase
ETK49_RS21935	COG3833	ABC-type maltose transport systems, permease component
ETK49_RS21940	COG1175	transmembrane transport
ETK49_RS21945	COG2182	Extracellular solute-binding protein
ETK49_RS21950	COG1609	Transcriptional regulator
ETK49_RS21960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETK49_RS21965	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ETK49_RS21970	COG1940	carbohydrate kinase activity
ETK49_RS21995	COG1012	belongs to the aldehyde dehydrogenase family
ETK49_RS21995	COG1454	alcohol dehydrogenase
ETK49_RS22000	COG0450	alkyl hydroperoxide reductase
ETK49_RS22005	COG3634	alkyl hydroperoxide reductase activity
ETK49_RS22030	COG1131	(ABC) transporter
ETK49_RS22035	COG0842	Transport permease protein
ETK49_RS22040	COG4585	Histidine kinase
ETK49_RS22045	COG2197	response regulator
ETK49_RS22070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ETK49_RS22085	COG0456	acetyltransferase
ETK49_RS22100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK49_RS22105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ETK49_RS22110	COG4853	Protein conserved in bacteria
ETK49_RS22115	COG4863	YycH protein
ETK49_RS22120	COG5002	protein histidine kinase activity
ETK49_RS22125	COG0745	RESPONSE REGULATOR receiver
ETK49_RS22150	COG1051	belongs to the nudix hydrolase family
ETK49_RS22155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ETK49_RS22165	COG0305	Participates in initiation and elongation during chromosome replication
ETK49_RS22180	COG3093	addiction module antidote protein HigA
ETK49_RS22185	COG2807	transmembrane transport
ETK49_RS22190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ETK49_RS22195	COG0363	glucosamine-6-phosphate deaminase activity
ETK49_RS22200	COG2188	Transcriptional regulator
ETK49_RS22205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ETK49_RS22210	COG1263	PTS System
ETK49_RS22210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK49_RS22215	COG0359	binds to the 23S rRNA
ETK49_RS22220	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ETK49_RS22225	COG4241	membrane
ETK49_RS22230	COG5577	PFAM Coat F domain
ETK49_RS22235	COG0589	response to stress
ETK49_RS22240	COG0659	secondary active sulfate transmembrane transporter activity
ETK49_RS22245	COG2271	Major facilitator Superfamily
ETK49_RS22250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ETK49_RS22255	COG0629	single-stranded DNA binding
ETK49_RS22260	COG0360	Binds together with S18 to 16S ribosomal RNA
ETK49_RS22265	COG0012	GTP binding
ETK49_RS22275	COG4481	Protein conserved in bacteria
ETK49_RS22280	COG3949	Membrane
ETK49_RS22290	COG1475	DNA binding
ETK49_RS22295	COG1192	Involved in chromosome partitioning
ETK49_RS22300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ETK49_RS22310	COG1475	DNA binding
ETK49_RS22315	COG0357	Ribosomal RNA small subunit methyltransferase G
ETK49_RS22320	COG0445	tRNA wobble uridine modification
ETK49_RS22325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ETK49_RS22330	COG1847	R3H domain protein
ETK49_RS22335	COG0706	membrane insertase activity
ETK49_RS22340	COG0594	ribonuclease P activity