locus-tag	class	description
D9842_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS00040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9842_RS00060	COG0583	DNA-binding transcription factor activity
D9842_RS00070	COG2207	Transcriptional regulator
D9842_RS00075	COG1472	Belongs to the glycosyl hydrolase 3 family
D9842_RS00080	COG0671	phosphoesterase, PA-phosphatase related
D9842_RS00085	COG2112	serine threonine protein kinase
D9842_RS00090	COG2814	Major facilitator Superfamily
D9842_RS00100	COG2508	Transcriptional regulator
D9842_RS00105	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS00110	COG1024	Enoyl-CoA hydratase
D9842_RS00115	COG0183	Belongs to the thiolase family
D9842_RS00120	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS00125	COG0824	Thioesterase
D9842_RS00130	COG1960	acyl-CoA dehydrogenase activity
D9842_RS00140	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9842_RS00160	COG1414	Transcriptional regulator
D9842_RS00165	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9842_RS00180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9842_RS00185	COG3314	Sporulation integral membrane protein YlbJ
D9842_RS00190	COG2972	Histidine kinase
D9842_RS00195	COG4753	response regulator
D9842_RS00195	COG2207	Transcriptional regulator
D9842_RS00205	COG0747	negative chemotaxis
D9842_RS00215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS00225	COG0444	Belongs to the ABC transporter superfamily
D9842_RS00230	COG4608	Belongs to the ABC transporter superfamily
D9842_RS00245	COG2211	Major facilitator Superfamily
D9842_RS00250	COG0583	DNA-binding transcription factor activity
D9842_RS00255	COG0183	Belongs to the thiolase family
D9842_RS00260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9842_RS00265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9842_RS00285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9842_RS00290	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS00295	COG0531	amino acid
D9842_RS00300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9842_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS00320	COG0833	amino acid
D9842_RS00360	COG1609	Transcriptional regulator
D9842_RS00365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9842_RS00370	COG0800	Aldolase
D9842_RS00375	COG1312	Catalyzes the dehydration of D-mannonate
D9842_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS00385	COG1349	DNA-binding transcription factor activity
D9842_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS00395	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D9842_RS00400	COG5578	integral membrane protein
D9842_RS00405	COG1175	transmembrane transport
D9842_RS00410	COG0395	ABC-type sugar transport system, permease component
D9842_RS00415	COG1653	transport
D9842_RS00420	COG2972	Histidine kinase
D9842_RS00425	COG2207	Transcriptional regulator
D9842_RS00425	COG4753	response regulator
D9842_RS00470	COG2323	membrane
D9842_RS00490	COG4974	Belongs to the 'phage' integrase family
D9842_RS00535	COG5002	protein histidine kinase activity
D9842_RS00540	COG0745	RESPONSE REGULATOR receiver
D9842_RS00550	COG0247	lactate metabolic process
D9842_RS00555	COG1139	Iron-sulfur cluster binding protein
D9842_RS00560	COG1556	Lactate utilization protein
D9842_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS00565	COG3347	Dehydrogenase
D9842_RS00570	COG1349	DNA-binding transcription factor activity
D9842_RS00580	COG1070	Carbohydrate kinase
D9842_RS00585	COG4806	L-rhamnose isomerase
D9842_RS00595	COG2972	Histidine kinase
D9842_RS00600	COG2207	Transcriptional regulator
D9842_RS00600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9842_RS00605	COG1129	ABC transporter
D9842_RS00610	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9842_RS00635	COG2252	PERMEase
D9842_RS00640	COG0534	Mate efflux family protein
D9842_RS00650	COG2972	Histidine kinase
D9842_RS00655	COG2207	Transcriptional regulator
D9842_RS00655	COG4753	response regulator
D9842_RS00660	COG1653	transport
D9842_RS00665	COG1175	transmembrane transport
D9842_RS00670	COG0395	ABC-type sugar transport system, permease component
D9842_RS00675	COG5578	integral membrane protein
D9842_RS00680	COG1653	transport
D9842_RS00685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9842_RS00690	COG2755	lipolytic protein G-D-S-L family
D9842_RS00695	COG1874	Beta-galactosidase
D9842_RS00700	COG1486	melibiose metabolic process
D9842_RS00710	COG3401	FG-GAP repeat protein
D9842_RS00715	COG3507	Belongs to the glycosyl hydrolase 43 family
D9842_RS00730	COG1609	Transcriptional regulator
D9842_RS00750	COG0395	ABC-type sugar transport system, permease component
D9842_RS00755	COG3534	alpha-L-arabinofuranosidase
D9842_RS00760	COG3940	Belongs to the glycosyl hydrolase 43 family
D9842_RS00765	COG3507	Belongs to the glycosyl hydrolase 43 family
D9842_RS00770	COG1069	ribulokinase activity
D9842_RS00785	COG3534	alpha-L-arabinofuranosidase
D9842_RS00795	COG3507	Belongs to the glycosyl hydrolase 43 family
D9842_RS00815	COG1349	DNA-binding transcription factor activity
D9842_RS00825	COG0431	NADPH-dependent FMN reductase
D9842_RS00830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9842_RS00835	COG2207	Transcriptional regulator
D9842_RS00835	COG1609	Transcriptional regulator
D9842_RS00845	COG0656	L-ascorbic acid biosynthetic process
D9842_RS00865	COG1653	transport
D9842_RS00870	COG2972	Histidine kinase
D9842_RS00875	COG2207	Transcriptional regulator
D9842_RS00875	COG4753	response regulator
D9842_RS00880	COG3711	transcriptional antiterminator
D9842_RS00885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9842_RS00885	COG1263	PTS System
D9842_RS00895	COG1621	beta-fructofuranosidase activity
D9842_RS00905	COG2721	sulfolactate sulfo-lyase activity
D9842_RS00910	COG0246	Mannitol dehydrogenase
D9842_RS00915	COG1904	glucuronate isomerase
D9842_RS00920	COG1937	Protein conserved in bacteria
D9842_RS00930	COG0697	spore germination
D9842_RS00955	COG2233	PERMEase
D9842_RS00970	COG2351	hydroxyisourate hydrolase activity
D9842_RS00975	COG4191	Histidine kinase
D9842_RS00980	COG2508	Transcriptional regulator
D9842_RS00985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9842_RS00990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D9842_RS00995	COG0154	amidase activity
D9842_RS01010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9842_RS01015	COG0405	Gamma-glutamyltransferase
D9842_RS01025	COG1522	sequence-specific DNA binding
D9842_RS01030	COG2059	Chromate
D9842_RS01035	COG2059	Chromate
D9842_RS01050	COG1834	amidinotransferase
D9842_RS01070	COG1609	Transcriptional regulator
D9842_RS01075	COG0366	Alpha amylase catalytic
D9842_RS01080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS01085	COG1309	transcriptional regulator
D9842_RS01090	COG0534	Mate efflux family protein
D9842_RS01095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9842_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS01110	COG0561	phosphatase activity
D9842_RS01115	COG4895	conserved protein (DUF2196)
D9842_RS01140	COG1136	(ABC) transporter
D9842_RS01145	COG0577	efflux transmembrane transporter activity
D9842_RS01145	COG1136	(ABC) transporter
D9842_RS01180	COG3480	Lon protease (S16) C-terminal proteolytic domain
D9842_RS01185	COG0673	inositol 2-dehydrogenase activity
D9842_RS01195	COG0673	inositol 2-dehydrogenase activity
D9842_RS01200	COG1609	Transcriptional regulator
D9842_RS01205	COG1609	Transcriptional regulator
D9842_RS01220	COG1175	transmembrane transport
D9842_RS01240	COG2205	protein histidine kinase activity
D9842_RS01255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9842_RS01260	COG0493	'glutamate synthase
D9842_RS01265	COG0167	dihydroorotate dehydrogenase activity
D9842_RS01265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D9842_RS01285	COG2508	Transcriptional regulator
D9842_RS01290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9842_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS01300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9842_RS01315	COG1116	anion transmembrane transporter activity
D9842_RS01320	COG5278	phosphoserine phosphatase activity
D9842_RS01320	COG0840	transmembrane signaling receptor activity
D9842_RS01325	COG0531	amino acid
D9842_RS01335	COG3665	Urea carboxylase-associated protein
D9842_RS01340	COG0439	Biotin carboxylase
D9842_RS01355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9842_RS01370	COG1216	Glycosyl transferase, family 2
D9842_RS01425	COG1999	signal sequence binding
D9842_RS01430	COG0785	Cytochrome C biogenesis protein
D9842_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS01465	COG5578	integral membrane protein
D9842_RS01480	COG0506	proline dehydrogenase activity
D9842_RS01485	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS01495	COG2268	Band 7 protein
D9842_RS01500	COG2508	Transcriptional regulator
D9842_RS01515	COG0561	phosphatase activity
D9842_RS01520	COG1278	Cold shock
D9842_RS01530	COG2318	DinB family
D9842_RS01540	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS01545	COG1113	amino acid transport
D9842_RS01555	COG1280	lysine exporter protein (LysE YggA)
D9842_RS01560	COG1119	ATPase activity
D9842_RS01565	COG3829	transcription factor binding
D9842_RS01575	COG1509	lysine 2,3-aminomutase activity
D9842_RS01585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9842_RS01590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9842_RS01595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9842_RS01600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9842_RS01605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9842_RS01610	COG2323	membrane
D9842_RS01625	COG1595	DNA-templated transcription, initiation
D9842_RS01770	COG2502	aspartate--ammonia ligase
D9842_RS01800	COG3153	acetyltransferase
D9842_RS01800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS01805	COG0456	acetyltransferase
D9842_RS01825	COG0514	ATP-dependent DNA helicase (RecQ)
D9842_RS01840	COG0596	Alpha beta hydrolase
D9842_RS01865	COG2706	6-phosphogluconolactonase activity
D9842_RS01870	COG1132	(ABC) transporter
D9842_RS01880	COG2116	formate transmembrane transporter activity
D9842_RS01890	COG3829	transcription factor binding
D9842_RS01895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9842_RS01900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9842_RS01910	COG3314	Sporulation integral membrane protein YlbJ
D9842_RS01915	COG1609	Transcriptional regulator
D9842_RS01920	COG1011	Hydrolase
D9842_RS01935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9842_RS01945	COG2084	Dehydrogenase
D9842_RS01950	COG0698	ribose 5-phosphate isomerase
D9842_RS01960	COG1175	transmembrane transport
D9842_RS01965	COG0395	ABC-type sugar transport system, permease component
D9842_RS01970	COG1609	Transcriptional regulator
D9842_RS01975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9842_RS01980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9842_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS01995	COG1929	Belongs to the glycerate kinase type-1 family
D9842_RS02000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9842_RS02015	COG2720	vancomycin resistance protein
D9842_RS02030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D9842_RS02035	COG0385	Bile acid
D9842_RS02040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9842_RS02045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D9842_RS02050	COG1116	anion transmembrane transporter activity
D9842_RS02055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9842_RS02060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9842_RS02080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9842_RS02085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9842_RS02090	COG2329	Antibiotic biosynthesis monooxygenase
D9842_RS02100	COG0347	Belongs to the P(II) protein family
D9842_RS02105	COG0004	ammonium transporteR
D9842_RS02150	COG1363	Peptidase, m42
D9842_RS02175	COG1131	(ABC) transporter
D9842_RS02190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9842_RS02195	COG4974	Belongs to the 'phage' integrase family
D9842_RS02205	COG0028	Belongs to the TPP enzyme family
D9842_RS02210	COG3764	Sortase (surface protein transpeptidase)
D9842_RS02220	COG0697	spore germination
D9842_RS02240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9842_RS02245	COG2258	MOSC domain
D9842_RS02255	COG0789	Transcriptional regulator
D9842_RS02270	COG3541	Predicted nucleotidyltransferase
D9842_RS02275	COG1846	Transcriptional regulator
D9842_RS02285	COG1793	dna ligase
D9842_RS02285	COG3285	dna ligase
D9842_RS02290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9842_RS02295	COG1523	belongs to the glycosyl hydrolase 13 family
D9842_RS02300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D9842_RS02310	COG0586	Pfam SNARE associated Golgi protein
D9842_RS02315	COG1191	sigma factor activity
D9842_RS02335	COG0501	Belongs to the peptidase M48B family
D9842_RS02340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9842_RS02360	COG3594	Acyltransferase
D9842_RS02365	COG5002	protein histidine kinase activity
D9842_RS02370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9842_RS02375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9842_RS02380	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D9842_RS02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS02390	COG0436	Aminotransferase
D9842_RS02395	COG1850	ribulose-bisphosphate carboxylase activity
D9842_RS02400	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D9842_RS02405	COG0235	Class ii aldolase
D9842_RS02410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9842_RS02415	COG0488	(ABC) transporter
D9842_RS02425	COG2861	carbohydrate metabolic process
D9842_RS02440	COG1846	Transcriptional regulator
D9842_RS02445	COG1360	Flagellar Motor Protein
D9842_RS02450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9842_RS02465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9842_RS02470	COG0542	response to heat
D9842_RS02475	COG3949	Membrane
D9842_RS02480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9842_RS02490	COG1253	flavin adenine dinucleotide binding
D9842_RS02500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9842_RS02505	COG0720	synthase
D9842_RS02510	COG0602	queuosine metabolic process
D9842_RS02515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9842_RS02525	COG4873	Protein conserved in bacteria
D9842_RS02530	COG4667	esterase of the alpha-beta hydrolase superfamily
D9842_RS02540	COG3773	Cell wall hydrolase
D9842_RS02560	COG2244	polysaccharide biosynthetic process
D9842_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS02570	COG2217	Heavy metal translocating P-type atpase
D9842_RS02580	COG0463	Glycosyl transferase, family 2
D9842_RS02590	COG0006	proline dipeptidase activity
D9842_RS02595	COG1525	nuclease
D9842_RS02600	COG2200	EAL domain
D9842_RS02630	COG3711	transcriptional antiterminator
D9842_RS02635	COG2190	(PTS) system
D9842_RS02635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9842_RS02635	COG1263	PTS System
D9842_RS02640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS02645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9842_RS02655	COG1533	DNA photolyase activity
D9842_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS02670	COG2084	Dehydrogenase
D9842_RS02675	COG0768	penicillin binding
D9842_RS02680	COG1960	acyl-CoA dehydrogenase activity
D9842_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS02695	COG1309	transcriptional regulator
D9842_RS02700	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS02705	COG1024	Enoyl-CoA hydratase
D9842_RS02725	COG1960	acyl-CoA dehydrogenase activity
D9842_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS02735	COG1024	Enoyl-CoA hydratase
D9842_RS02745	COG4191	Histidine kinase
D9842_RS02750	COG0436	Aminotransferase
D9842_RS02755	COG0598	Magnesium transport protein CorA
D9842_RS02765	COG2318	DinB family
D9842_RS02775	COG2203	Gaf domain
D9842_RS02775	COG2199	diguanylate cyclase activity
D9842_RS02800	COG0835	chemotaxis
D9842_RS02800	COG0784	Response regulator, receiver
D9842_RS02815	COG3437	response regulator, receiver
D9842_RS02815	COG2770	Histidine kinase
D9842_RS02820	COG2814	Major facilitator Superfamily
D9842_RS02825	COG1376	ErfK ybiS ycfS ynhG family protein
D9842_RS02830	COG0248	Ppx GppA phosphatase
D9842_RS02840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9842_RS02845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9842_RS02850	COG5001	Diguanylate cyclase
D9842_RS02850	COG3300	MHYT domain
D9842_RS02855	COG1408	metallophosphoesterase
D9842_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS02865	COG2200	EAL domain
D9842_RS02880	COG4703	Protein of unknown function (DUF1797)
D9842_RS02885	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D9842_RS02895	COG0517	IMP dehydrogenase activity
D9842_RS02900	COG0477	Major facilitator Superfamily
D9842_RS02910	COG0583	DNA-binding transcription factor activity
D9842_RS02915	COG2171	N-acyltransferase activity
D9842_RS02920	COG1473	amidohydrolase
D9842_RS02930	COG0668	transmembrane transport
D9842_RS02935	COG0450	alkyl hydroperoxide reductase
D9842_RS02940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS02945	COG0746	molybdenum cofactor guanylyltransferase activity
D9842_RS02950	COG0303	'Molybdopterin
D9842_RS02955	COG1763	Mo-molybdopterin cofactor biosynthetic process
D9842_RS02960	COG0314	molybdopterin synthase activity
D9842_RS02965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9842_RS02970	COG4149	molybdate abc transporter
D9842_RS02985	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D9842_RS02985	COG0392	lysyltransferase activity
D9842_RS03000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9842_RS03005	COG0004	ammonium transporteR
D9842_RS03015	COG2176	DNA-directed DNA polymerase activity
D9842_RS03020	COG0840	transmembrane signaling receptor activity
D9842_RS03040	COG1970	mechanosensitive ion channel activity
D9842_RS03045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D9842_RS03050	COG1132	(ABC) transporter
D9842_RS03055	COG1132	(ABC) transporter
D9842_RS03060	COG2851	Citrate transporter
D9842_RS03065	COG3290	protein histidine kinase activity
D9842_RS03070	COG4565	transcriptional regulatory protein
D9842_RS03075	COG3181	Tripartite tricarboxylate transporter family receptor
D9842_RS03095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9842_RS03100	COG1136	(ABC) transporter
D9842_RS03105	COG0577	efflux transmembrane transporter activity
D9842_RS03110	COG1349	DNA-binding transcription factor activity
D9842_RS03115	COG1105	Belongs to the carbohydrate kinase PfkB family
D9842_RS03120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9842_RS03120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9842_RS03120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS03125	COG1764	response to oxidative stress
D9842_RS03150	COG1966	Carbon starvation protein
D9842_RS03155	COG1279	arginine transmembrane transporter activity
D9842_RS03160	COG1266	CAAX protease self-immunity
D9842_RS03170	COG5577	PFAM Coat F domain
D9842_RS03175	COG0488	(ABC) transporter
D9842_RS03185	COG3275	phosphorelay sensor kinase activity
D9842_RS03190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9842_RS03195	COG0523	cobalamin synthesis protein
D9842_RS03200	COG2309	aminopeptidase activity
D9842_RS03205	COG1960	acyl-CoA dehydrogenase activity
D9842_RS03215	COG1077	Cell shape determining protein MreB Mrl
D9842_RS03225	COG0514	ATP-dependent DNA helicase (RecQ)
D9842_RS03230	COG3180	Ammonia monooxygenase
D9842_RS03235	COG0569	domain protein
D9842_RS03240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9842_RS03245	COG5503	Protein of unknown function (DUF1447)
D9842_RS03250	COG0697	spore germination
D9842_RS03255	COG0242	peptide deformylase activity
D9842_RS03270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9842_RS03275	COG0022	dehydrogenase e1 component
D9842_RS03280	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9842_RS03285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9842_RS03290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS03300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9842_RS03320	COG1982	Orn Lys Arg decarboxylase major
D9842_RS03330	COG4476	Belongs to the UPF0223 family
D9842_RS03335	COG4493	Belongs to the UPF0637 family
D9842_RS03345	COG0483	inositol monophosphate 1-phosphatase activity
D9842_RS03360	COG1217	gtp-binding protein TYPA
D9842_RS03375	COG4896	Protein conserved in bacteria
D9842_RS03390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9842_RS03395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9842_RS03400	COG4838	Belongs to the UPF0358 family
D9842_RS03405	COG0772	Belongs to the SEDS family
D9842_RS03410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D9842_RS03415	COG1612	heme a metabolic process
D9842_RS03425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9842_RS03425	COG2010	Cytochrome c
D9842_RS03430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9842_RS03435	COG1845	cytochrome c oxidase, subunit III
D9842_RS03445	COG3336	cytochrome c oxidase
D9842_RS03460	COG0628	permease
D9842_RS03475	COG2340	Cysteine-rich secretory protein family
D9842_RS03500	COG3679	Belongs to the UPF0342 family
D9842_RS03515	COG0742	ribosomal rna small subunit methyltransferase
D9842_RS03520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9842_RS03525	COG3314	Sporulation integral membrane protein YlbJ
D9842_RS03530	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9842_RS03535	COG3480	Lon protease (S16) C-terminal proteolytic domain
D9842_RS03540	COG1323	Belongs to the UPF0348 family
D9842_RS03545	COG1399	metal-binding, possibly nucleic acid-binding protein
D9842_RS03550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9842_RS03555	COG1024	Enoyl-CoA hydratase
D9842_RS03565	COG0454	-acetyltransferase
D9842_RS03570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9842_RS03580	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D9842_RS03585	COG2001	Belongs to the MraZ family
D9842_RS03590	COG0275	rRNA processing
D9842_RS03595	COG4839	cell division protein FtsL
D9842_RS03600	COG0768	penicillin binding
D9842_RS03605	COG0768	penicillin binding
D9842_RS03615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9842_RS03620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9842_RS03625	COG0772	Belongs to the SEDS family
D9842_RS03630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9842_RS03635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9842_RS03640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9842_RS03645	COG3879	Bacterial protein of unknown function (DUF881)
D9842_RS03650	COG3879	Bacterial protein of unknown function (DUF881)
D9842_RS03655	COG3856	small basic protein
D9842_RS03660	COG0849	cell division
D9842_RS03665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9842_RS03675	COG1191	sigma factor activity
D9842_RS03680	COG1191	sigma factor activity
D9842_RS03685	COG1873	PFAM PRC-barrel domain
D9842_RS03695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D9842_RS03700	COG1799	cell septum assembly
D9842_RS03705	COG0762	integral membrane protein
D9842_RS03710	COG2302	S4 RNA-binding domain
D9842_RS03715	COG3599	regulation of cell shape
D9842_RS03720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9842_RS03730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9842_RS03735	COG0564	pseudouridine synthase activity
D9842_RS03740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D9842_RS03750	COG0540	Belongs to the ATCase OTCase family
D9842_RS03755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9842_RS03760	COG0505	Belongs to the CarA family
D9842_RS03765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9842_RS03770	COG0543	2 iron, 2 sulfur cluster binding
D9842_RS03780	COG0284	orotidine-5'-phosphate decarboxylase activity
D9842_RS03800	COG0306	phosphate transporter
D9842_RS03810	COG0529	Catalyzes the synthesis of activated sulfate
D9842_RS03820	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D9842_RS03825	COG1648	precorrin-2 dehydrogenase activity
D9842_RS03840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9842_RS03845	COG1561	YicC-like family, N-terminal region
D9842_RS03850	COG2052	Domain of unknown function (DUF370)
D9842_RS03855	COG0194	GDP metabolic process
D9842_RS03865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9842_RS03870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9842_RS03885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9842_RS03885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9842_RS03890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9842_RS03895	COG0631	protein serine/threonine phosphatase activity
D9842_RS03900	COG2815	serine threonine protein kinase
D9842_RS03900	COG0515	serine threonine protein kinase
D9842_RS03905	COG1162	GTPase activity
D9842_RS03910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9842_RS03920	COG1564	THIamine pyrophosphokinase
D9842_RS03930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9842_RS03935	COG1302	Protein conserved in bacteria
D9842_RS03940	COG1461	Dihydroxyacetone kinase
D9842_RS03945	COG1760	l-serine dehydratase
D9842_RS03950	COG1760	l-serine dehydratase
D9842_RS03955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9842_RS03960	COG1349	DNA-binding transcription factor activity
D9842_RS03965	COG0416	fatty acid biosynthetic process
D9842_RS03970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9842_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS03980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9842_RS03985	COG0571	ribonuclease III activity
D9842_RS03990	COG1196	nuclear chromosome segregation
D9842_RS03995	COG0552	protein localization to endoplasmic reticulum
D9842_RS04005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9842_RS04010	COG0228	four-way junction DNA binding
D9842_RS04015	COG1837	Belongs to the UPF0109 family
D9842_RS04025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9842_RS04030	COG0336	Belongs to the RNA methyltransferase TrmD family
D9842_RS04035	COG0335	large ribosomal subunit rRNA binding
D9842_RS04050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9842_RS04060	COG2257	FlhB HrpN YscU SpaS Family
D9842_RS04065	COG0045	succinate-CoA ligase (ADP-forming) activity
D9842_RS04070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9842_RS04075	COG0758	DNA mediated transformation
D9842_RS04080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9842_RS04085	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D9842_RS04090	COG4974	Belongs to the 'phage' integrase family
D9842_RS04095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9842_RS04100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9842_RS04105	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9842_RS04110	COG1815	bacterial-type flagellum-dependent cell motility
D9842_RS04115	COG1558	bacterial-type flagellum-dependent cell motility
D9842_RS04120	COG1677	Flagellar hook-basal body complex protein FliE
D9842_RS04125	COG1766	The M ring may be actively involved in energy transduction
D9842_RS04130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9842_RS04135	COG1317	bacterial-type flagellum organization
D9842_RS04140	COG1157	protein secretion by the type III secretion system
D9842_RS04145	COG2882	bacterial-type flagellum organization
D9842_RS04155	COG3144	bacterial-type flagellum assembly
D9842_RS04160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9842_RS04170	COG4786	Flagellar basal body rod
D9842_RS04175	COG1582	Flagellar protein (FlbD)
D9842_RS04180	COG1580	Controls the rotational direction of flagella during chemotaxis
D9842_RS04185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9842_RS04190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9842_RS04190	COG1776	CheC inhibitor of MCP methylation
D9842_RS04195	COG2201	protein-glutamate methylesterase activity
D9842_RS04200	COG3190	flagellar
D9842_RS04205	COG1338	Plays a role in the flagellum-specific transport system
D9842_RS04210	COG1987	bacterial-type flagellum assembly
D9842_RS04215	COG1684	flagellar biosynthetic protein fliR
D9842_RS04220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9842_RS04225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9842_RS04230	COG1419	protein localization to endoplasmic reticulum
D9842_RS04235	COG0455	bacterial-type flagellum organization
D9842_RS04240	COG2201	protein-glutamate methylesterase activity
D9842_RS04245	COG0643	Histidine kinase
D9842_RS04245	COG2198	Histidine kinase
D9842_RS04250	COG0835	chemotaxis
D9842_RS04255	COG1776	CheC inhibitor of MCP methylation
D9842_RS04260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9842_RS04265	COG1191	sigma factor activity
D9842_RS04285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9842_RS04295	COG0233	cytoplasmic translational termination
D9842_RS04300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9842_RS04305	COG4589	Belongs to the CDS family
D9842_RS04310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9842_RS04315	COG0750	zinc metalloprotease
D9842_RS04325	COG2176	DNA-directed DNA polymerase activity
D9842_RS04330	COG0779	Required for maturation of 30S ribosomal subunits
D9842_RS04335	COG0195	Participates in both transcription termination and antitermination
D9842_RS04340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D9842_RS04345	COG1358	cellular component organization or biogenesis
D9842_RS04350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9842_RS04355	COG1550	Protein conserved in bacteria
D9842_RS04360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9842_RS04365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9842_RS04370	COG0196	riboflavin kinase activity
D9842_RS04380	COG1185	polyribonucleotide nucleotidyltransferase activity
D9842_RS04385	COG0726	polysaccharide deacetylase
D9842_RS04390	COG0612	Peptidase, M16
D9842_RS04395	COG1873	PFAM PRC-barrel domain
D9842_RS04400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9842_RS04405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9842_RS04410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9842_RS04415	COG0527	aspartate kinase activity
D9842_RS04425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9842_RS04430	COG0740	serine-type endopeptidase activity
D9842_RS04440	COG1674	ftsk spoiiie
D9842_RS04440	COG4980	gas vesicle protein
D9842_RS04445	COG2188	Transcriptional regulator
D9842_RS04450	COG1744	ABC transporter substrate-binding protein PnrA-like
D9842_RS04455	COG3845	ABC transporter
D9842_RS04460	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9842_RS04465	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9842_RS04475	COG2814	Major facilitator Superfamily
D9842_RS04480	COG0612	Peptidase, M16
D9842_RS04485	COG0612	Peptidase, M16
D9842_RS04490	COG0300	oxidoreductase activity
D9842_RS04505	COG1426	Protein conserved in bacteria
D9842_RS04510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9842_RS04515	COG1058	Belongs to the CinA family
D9842_RS04515	COG1546	Belongs to the CinA family
D9842_RS04520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D9842_RS04525	COG3344	reverse transcriptase
D9842_RS04530	COG1418	mRNA catabolic process
D9842_RS04535	COG1692	metallophosphoesterase
D9842_RS04540	COG2359	stage V sporulation protein S
D9842_RS04550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D9842_RS04550	COG0674	pyruvate-flavodoxin oxidoreductase activity
D9842_RS04555	COG1013	pyruvate-flavodoxin oxidoreductase activity
D9842_RS04560	COG1063	alcohol dehydrogenase
D9842_RS04565	COG0156	8-amino-7-oxononanoate synthase activity
D9842_RS04570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9842_RS04575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9842_RS04580	COG4550	Control of competence regulator ComK, YlbF/YmcA
D9842_RS04585	COG0025	NhaP-type Na H and K H
D9842_RS04595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9842_RS04600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9842_RS04605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9842_RS04620	COG0464	growth
D9842_RS04640	COG2860	membrane
D9842_RS04645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9842_RS04650	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D9842_RS04655	COG0789	Transcriptional regulator
D9842_RS04660	COG0174	glutamine synthetase
D9842_RS04665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9842_RS04670	COG1388	LysM domain
D9842_RS04675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9842_RS04680	COG4224	UPF0291 protein
D9842_RS04690	COG3763	UPF0154 protein
D9842_RS04775	COG1793	dna ligase
D9842_RS04780	COG1278	Cold shock
D9842_RS04790	COG0785	Cytochrome C biogenesis protein
D9842_RS04795	COG2201	protein-glutamate methylesterase activity
D9842_RS04800	COG4846	Membrane protein involved in cytochrome C biogenesis
D9842_RS04815	COG5577	PFAM Coat F domain
D9842_RS04825	COG2207	Transcriptional regulator
D9842_RS04830	COG0673	inositol 2-dehydrogenase activity
D9842_RS04855	COG2200	EAL domain
D9842_RS04860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9842_RS04870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9842_RS04900	COG0840	transmembrane signaling receptor activity
D9842_RS04905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9842_RS04915	COG2755	lipolytic protein G-D-S-L family
D9842_RS04930	COG0671	phosphoesterase, PA-phosphatase related
D9842_RS04940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9842_RS04945	COG1454	alcohol dehydrogenase
D9842_RS04955	COG1607	acyl-coa hydrolase
D9842_RS04970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D9842_RS04975	COG1335	isochorismatase
D9842_RS04980	COG2514	catechol 2,3-dioxygenase activity
D9842_RS04995	COG5002	protein histidine kinase activity
D9842_RS05005	COG0071	Belongs to the small heat shock protein (HSP20) family
D9842_RS05025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9842_RS05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS05050	COG0824	Thioesterase
D9842_RS05060	COG4841	protein insertion into membrane
D9842_RS05065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9842_RS05070	COG1832	CoA-binding protein
D9842_RS05075	COG0187	DNA topoisomerase II activity
D9842_RS05080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9842_RS05090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9842_RS05105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9842_RS05110	COG0390	transport system, permease component
D9842_RS05115	COG2072	flavoprotein involved in K transport
D9842_RS05120	COG1683	Conserved Protein
D9842_RS05125	COG1609	Transcriptional regulator
D9842_RS05130	COG0561	phosphatase activity
D9842_RS05145	COG0861	Integral membrane protein TerC family
D9842_RS05185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9842_RS05190	COG2188	Transcriptional regulator
D9842_RS05200	COG1129	ABC transporter
D9842_RS05205	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9842_RS05210	COG0656	L-ascorbic acid biosynthetic process
D9842_RS05215	COG1070	Carbohydrate kinase
D9842_RS05220	COG2140	Oxalate decarboxylase
D9842_RS05225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9842_RS05240	COG0363	glucosamine-6-phosphate deaminase activity
D9842_RS05245	COG1129	ABC transporter
D9842_RS05250	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9842_RS05255	COG1879	ABC-type sugar transport system periplasmic component
D9842_RS05260	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS05270	COG1733	regulation of RNA biosynthetic process
D9842_RS05275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9842_RS05280	COG2271	Major facilitator Superfamily
D9842_RS05290	COG2186	Transcriptional regulator
D9842_RS05295	COG1312	Catalyzes the dehydration of D-mannonate
D9842_RS05315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9842_RS05320	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS05325	COG2721	sulfolactate sulfo-lyase activity
D9842_RS05355	COG0346	lactoylglutathione lyase activity
D9842_RS05360	COG0745	RESPONSE REGULATOR receiver
D9842_RS05365	COG5002	protein histidine kinase activity
D9842_RS05390	COG3829	transcription factor binding
D9842_RS05390	COG3290	protein histidine kinase activity
D9842_RS05405	COG2851	Citrate transporter
D9842_RS05415	COG1131	(ABC) transporter
D9842_RS05430	COG0662	Cupin 2, conserved barrel domain protein
D9842_RS05440	COG0604	alcohol dehydrogenase
D9842_RS05445	COG0129	dihydroxy-acid dehydratase activity
D9842_RS05450	COG3773	Cell wall hydrolase
D9842_RS05465	COG4443	Transcriptional Coactivator p15 (PC4)
D9842_RS05470	COG2814	Major facilitator Superfamily
D9842_RS05475	COG0656	L-ascorbic acid biosynthetic process
D9842_RS05480	COG3695	enzyme binding
D9842_RS05485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9842_RS05500	COG1309	transcriptional regulator
D9842_RS05505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9842_RS05510	COG0596	Alpha beta hydrolase
D9842_RS05515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS05520	COG1937	Protein conserved in bacteria
D9842_RS05525	COG2217	Heavy metal translocating P-type atpase
D9842_RS05530	COG2217	Heavy metal translocating P-type atpase
D9842_RS05540	COG0384	phenazine biosynthesis protein PhzF
D9842_RS05550	COG0747	negative chemotaxis
D9842_RS05565	COG0444	Belongs to the ABC transporter superfamily
D9842_RS05570	COG4608	Belongs to the ABC transporter superfamily
D9842_RS05575	COG0534	Mate efflux family protein
D9842_RS05595	COG0733	neurotransmitter:sodium symporter activity
D9842_RS05605	COG1388	LysM domain
D9842_RS05605	COG0791	NLP P60 protein
D9842_RS05615	COG5002	protein histidine kinase activity
D9842_RS05620	COG2204	response regulator
D9842_RS05630	COG3706	GGDEF domain
D9842_RS05635	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS05650	COG2323	membrane
D9842_RS05665	COG0456	acetyltransferase
D9842_RS05705	COG3706	GGDEF domain
D9842_RS05720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9842_RS05730	COG0105	UTP biosynthetic process
D9842_RS05735	COG3845	ABC transporter
D9842_RS05740	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9842_RS05745	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9842_RS05770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D9842_RS05775	COG1228	amidohydrolase
D9842_RS05780	COG0010	Belongs to the arginase family
D9842_RS05785	COG0589	response to stress
D9842_RS05790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9842_RS05805	COG0693	protein deglycase activity
D9842_RS05810	COG3835	regulator
D9842_RS05815	COG0277	FAD linked oxidase domain protein
D9842_RS05820	COG0247	lactate metabolic process
D9842_RS05830	COG2358	TRAP transporter, solute receptor (TAXI family
D9842_RS05845	COG0435	Glutathione S-transferase
D9842_RS05925	COG1492	cobalamin metabolic process
D9842_RS05930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D9842_RS05940	COG0778	Nitroreductase
D9842_RS05945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D9842_RS05950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9842_RS05960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D9842_RS05965	COG0406	alpha-ribazole phosphatase activity
D9842_RS05985	COG0778	Nitroreductase
D9842_RS05990	COG0310	cobalt ion transport
D9842_RS06005	COG1122	ATPase activity
D9842_RS06020	COG0697	spore germination
D9842_RS06025	COG0531	amino acid
D9842_RS06040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9842_RS06060	COG2816	NAD+ diphosphatase activity
D9842_RS06065	COG2223	nitrite transmembrane transporter activity
D9842_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9842_RS06075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9842_RS06090	COG3290	protein histidine kinase activity
D9842_RS06090	COG3829	transcription factor binding
D9842_RS06095	COG2376	Dihydroxyacetone kinase
D9842_RS06100	COG1461	Dihydroxyacetone kinase
D9842_RS06110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS06115	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D9842_RS06120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D9842_RS06135	COG1063	alcohol dehydrogenase
D9842_RS06145	COG4974	Belongs to the 'phage' integrase family
D9842_RS06150	COG0346	lactoylglutathione lyase activity
D9842_RS06160	COG1309	transcriptional regulator
D9842_RS06170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9842_RS06180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9842_RS06210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D9842_RS06220	COG2226	methyltransferase
D9842_RS06235	COG0386	Belongs to the glutathione peroxidase family
D9842_RS06240	COG1846	Transcriptional regulator
D9842_RS06245	COG0583	DNA-binding transcription factor activity
D9842_RS06250	COG2226	methyltransferase
D9842_RS06255	COG0725	ABC transporter, periplasmic molybdate-binding protein
D9842_RS06275	COG1595	DNA-templated transcription, initiation
D9842_RS06305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D9842_RS06315	COG3300	MHYT domain
D9842_RS06315	COG5001	Diguanylate cyclase
D9842_RS06335	COG0840	transmembrane signaling receptor activity
D9842_RS06350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9842_RS06360	COG0456	acetyltransferase
D9842_RS06380	COG3401	FG-GAP repeat protein
D9842_RS06385	COG5001	Diguanylate cyclase
D9842_RS06385	COG3300	MHYT domain
D9842_RS06390	COG1131	(ABC) transporter
D9842_RS06405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9842_RS06415	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9842_RS06420	COG0022	dehydrogenase e1 component
D9842_RS06425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9842_RS06430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9842_RS06435	COG3284	Transcriptional regulator
D9842_RS06445	COG4977	sequence-specific DNA binding
D9842_RS06495	COG1131	(ABC) transporter
D9842_RS06500	COG2188	Transcriptional regulator
D9842_RS06520	COG0583	DNA-binding transcription factor activity
D9842_RS06525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9842_RS06530	COG1131	(ABC) transporter
D9842_RS06540	COG0653	protein targeting
D9842_RS06560	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D9842_RS06565	COG1970	mechanosensitive ion channel activity
D9842_RS06570	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D9842_RS06595	COG0805	protein transport
D9842_RS06600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9842_RS06630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9842_RS06640	COG3711	transcriptional antiterminator
D9842_RS06650	COG1201	RNA secondary structure unwinding
D9842_RS06715	COG1205	dead DEAH box helicase
D9842_RS06715	COG1111	helicase
D9842_RS06720	COG1205	dead DEAH box helicase
D9842_RS06720	COG1111	helicase
D9842_RS06795	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D9842_RS06815	COG0210	DNA helicase
D9842_RS06840	COG1160	GTP binding
D9842_RS06860	COG3764	Sortase (surface protein transpeptidase)
D9842_RS06885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9842_RS06895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9842_RS06900	COG2188	Transcriptional regulator
D9842_RS06905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9842_RS06910	COG0395	ABC-type sugar transport system, permease component
D9842_RS06915	COG1175	transmembrane transport
D9842_RS06920	COG1653	transport
D9842_RS06925	COG2222	sugar isomerase
D9842_RS06975	COG1472	Belongs to the glycosyl hydrolase 3 family
D9842_RS06980	COG1472	Belongs to the glycosyl hydrolase 3 family
D9842_RS06985	COG2197	response regulator
D9842_RS07000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D9842_RS07015	COG1136	(ABC) transporter
D9842_RS07020	COG3850	Histidine kinase
D9842_RS07020	COG5002	protein histidine kinase activity
D9842_RS07045	COG0494	nUDIX hydrolase
D9842_RS07055	COG0243	molybdopterin cofactor binding
D9842_RS07065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9842_RS07070	COG3655	Transcriptional regulator
D9842_RS07090	COG2814	Major facilitator Superfamily
D9842_RS07100	COG0395	ABC-type sugar transport system, permease component
D9842_RS07105	COG1175	transmembrane transport
D9842_RS07110	COG1653	transport
D9842_RS07115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9842_RS07120	COG2188	Transcriptional regulator
D9842_RS07135	COG4684	Psort location CytoplasmicMembrane, score
D9842_RS07210	COG5444	nuclease activity
D9842_RS07225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9842_RS07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9842_RS07230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9842_RS07260	COG0024	Methionine aminopeptidase
D9842_RS07285	COG2312	Erythromycin esterase
D9842_RS07300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS07390	COG3620	sequence-specific DNA binding
D9842_RS07400	COG2814	Major facilitator Superfamily
D9842_RS07405	COG4978	Transcriptional regulator
D9842_RS07405	COG0789	Transcriptional regulator
D9842_RS07410	COG1126	abc transporter atp-binding protein
D9842_RS07415	COG0765	amino acid transport
D9842_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9842_RS07440	COG1404	Belongs to the peptidase S8 family
D9842_RS07445	COG0095	Lipoate-protein ligase
D9842_RS07455	COG2814	Major facilitator Superfamily
D9842_RS07470	COG1595	DNA-templated transcription, initiation
D9842_RS07495	COG1051	belongs to the nudix hydrolase family
D9842_RS07500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9842_RS07505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D9842_RS07510	COG1555	photosystem II stabilization
D9842_RS07510	COG1596	polysaccharide export
D9842_RS07525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9842_RS07580	COG0412	Dienelactone hydrolase
D9842_RS07600	COG0768	penicillin binding
D9842_RS07625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9842_RS07660	COG0772	Belongs to the SEDS family
D9842_RS07700	COG4682	membrane
D9842_RS07710	COG0604	alcohol dehydrogenase
D9842_RS07765	COG2247	cell wall binding repeat
D9842_RS07765	COG2385	sporulation resulting in formation of a cellular spore
D9842_RS07775	COG1088	dTDP-glucose 4,6-dehydratase activity
D9842_RS07780	COG1442	glycosyl transferase family 8
D9842_RS07785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9842_RS07790	COG1216	Glycosyl transferase, family 2
D9842_RS07825	COG5566	PFAM Mor transcription activator
D9842_RS07835	COG3153	acetyltransferase
D9842_RS07835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS07845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS07845	COG3153	acetyltransferase
D9842_RS07850	COG0531	amino acid
D9842_RS07860	COG1011	Hydrolase
D9842_RS07880	COG0454	-acetyltransferase
D9842_RS07895	COG0740	serine-type endopeptidase activity
D9842_RS07965	COG0697	spore germination
D9842_RS07985	COG0305	Participates in initiation and elongation during chromosome replication
D9842_RS07995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9842_RS08000	COG0697	spore germination
D9842_RS08005	COG5001	Diguanylate cyclase
D9842_RS08010	COG2814	Major facilitator Superfamily
D9842_RS08025	COG3246	L-lysine catabolic process to acetate
D9842_RS08035	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS08060	COG3408	Glycogen debranching enzyme
D9842_RS08065	COG2211	Major facilitator Superfamily
D9842_RS08085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D9842_RS08125	COG1309	transcriptional regulator
D9842_RS08130	COG1917	Cupin 2, conserved barrel domain protein
D9842_RS08135	COG2814	Major facilitator Superfamily
D9842_RS08175	COG0697	spore germination
D9842_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS08205	COG0456	acetyltransferase
D9842_RS08210	COG1846	Transcriptional regulator
D9842_RS08215	COG5609	conserved protein (DUF2294)
D9842_RS08225	COG0288	reversible hydration of carbon dioxide
D9842_RS08230	COG3002	Belongs to the UPF0753 family
D9842_RS08235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9842_RS08280	COG2814	Major facilitator Superfamily
D9842_RS08380	COG0456	acetyltransferase
D9842_RS08420	COG2323	membrane
D9842_RS08445	COG3773	Cell wall hydrolase
D9842_RS08455	COG1388	LysM domain
D9842_RS08455	COG3409	Peptidoglycan-binding domain 1 protein
D9842_RS08455	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9842_RS08480	COG0768	penicillin binding
D9842_RS08485	COG0697	spore germination
D9842_RS08490	COG0662	Cupin 2, conserved barrel domain protein
D9842_RS08490	COG2207	Transcriptional regulator
D9842_RS08540	COG5002	protein histidine kinase activity
D9842_RS08545	COG0745	RESPONSE REGULATOR receiver
D9842_RS08550	COG3336	cytochrome c oxidase
D9842_RS08565	COG5504	Zn-dependent protease
D9842_RS08575	COG1846	Transcriptional regulator
D9842_RS08580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS08600	COG2226	methyltransferase
D9842_RS08655	COG0693	protein deglycase activity
D9842_RS08710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9842_RS08720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9842_RS08725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9842_RS08730	COG0204	Acyl-transferase
D9842_RS08735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9842_RS08765	COG1595	DNA-templated transcription, initiation
D9842_RS08780	COG1811	Na channel or pump
D9842_RS08785	COG0789	Transcriptional regulator
D9842_RS08785	COG4978	Transcriptional regulator
D9842_RS08795	COG2723	6-phospho-beta-galactosidase activity
D9842_RS08805	COG0768	penicillin binding
D9842_RS08810	COG0768	penicillin binding
D9842_RS08830	COG0346	lactoylglutathione lyase activity
D9842_RS08845	COG3739	integral membrane protein
D9842_RS08850	COG3655	Transcriptional regulator
D9842_RS08865	COG2205	protein histidine kinase activity
D9842_RS08880	COG0745	RESPONSE REGULATOR receiver
D9842_RS08895	COG1846	Transcriptional regulator
D9842_RS08915	COG1742	UPF0060 membrane protein
D9842_RS08940	COG2814	Major facilitator Superfamily
D9842_RS09015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS09030	COG1595	DNA-templated transcription, initiation
D9842_RS09060	COG4129	membrane
D9842_RS09070	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D9842_RS09075	COG2755	lipolytic protein G-D-S-L family
D9842_RS09125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9842_RS09130	COG1819	glycosyl
D9842_RS09170	COG3773	Cell wall hydrolase
D9842_RS09180	COG0584	glycerophosphoryl diester phosphodiesterase
D9842_RS09210	COG2211	Major facilitator Superfamily
D9842_RS09220	COG2223	nitrite transmembrane transporter activity
D9842_RS09225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9842_RS09235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9842_RS09245	COG1357	PFAM Pentapeptide repeats (8 copies)
D9842_RS09265	COG2199	diguanylate cyclase activity
D9842_RS09265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9842_RS09270	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D9842_RS09270	COG2105	PFAM AIG2 family protein
D9842_RS09275	COG3546	catalase activity
D9842_RS09280	COG2205	protein histidine kinase activity
D9842_RS09360	COG2267	carboxylic ester hydrolase activity
D9842_RS09385	COG0243	molybdopterin cofactor binding
D9842_RS09400	COG0456	acetyltransferase
D9842_RS09420	COG1070	Carbohydrate kinase
D9842_RS09425	COG2610	gluconate transmembrane transporter activity
D9842_RS09430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D9842_RS09435	COG1737	Transcriptional regulator
D9842_RS09440	COG1164	Oligoendopeptidase f
D9842_RS09450	COG1024	Enoyl-CoA hydratase
D9842_RS09455	COG0439	Biotin carboxylase
D9842_RS09460	COG1960	acyl-CoA dehydrogenase activity
D9842_RS09465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9842_RS09470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9842_RS09475	COG0511	ligase activity, forming carbon-carbon bonds
D9842_RS09480	COG5506	Protein of unknown function (DUF1694)
D9842_RS09485	COG0003	Pfam Anion-transporting ATPase
D9842_RS09495	COG1966	Carbon starvation protein
D9842_RS09570	COG5444	nuclease activity
D9842_RS09590	COG1511	domain protein
D9842_RS09595	COG0433	COG0433 Predicted ATPase
D9842_RS09595	COG1674	ftsk spoiiie
D9842_RS09600	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9842_RS09605	COG5417	Belongs to the EsaB family
D9842_RS09625	COG3123	guanosine phosphorylase activity
D9842_RS09635	COG0708	Exodeoxyribonuclease III
D9842_RS09640	COG5553	Cysteine dioxygenase type I
D9842_RS09645	COG0697	spore germination
D9842_RS09675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9842_RS09700	COG2814	Major facilitator Superfamily
D9842_RS09705	COG0657	acetylesterase activity
D9842_RS09720	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS09725	COG1960	acyl-CoA dehydrogenase activity
D9842_RS09730	COG0183	Belongs to the thiolase family
D9842_RS09735	COG1960	acyl-CoA dehydrogenase activity
D9842_RS09740	COG0183	Belongs to the thiolase family
D9842_RS09775	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS09785	COG3383	formate dehydrogenase (NAD+) activity
D9842_RS09795	COG2223	nitrite transmembrane transporter activity
D9842_RS09800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9842_RS09805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9842_RS09815	COG1960	acyl-CoA dehydrogenase activity
D9842_RS09825	COG2353	YceI-like domain
D9842_RS09830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9842_RS09835	COG0702	epimerase
D9842_RS09840	COG2027	D-alanyl-D-alanine carboxypeptidase
D9842_RS09845	COG0656	L-ascorbic acid biosynthetic process
D9842_RS09855	COG2135	peptidase activity
D9842_RS09860	COG0400	carboxylic ester hydrolase activity
D9842_RS09865	COG0346	lactoylglutathione lyase activity
D9842_RS09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9842_RS09895	COG2199	diguanylate cyclase activity
D9842_RS09900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9842_RS09905	COG0516	GMP reductase activity
D9842_RS09905	COG0517	IMP dehydrogenase activity
D9842_RS09910	COG2176	DNA-directed DNA polymerase activity
D9842_RS09930	COG0640	Transcriptional regulator
D9842_RS09950	COG1011	Hydrolase
D9842_RS09960	COG2080	2 iron, 2 sulfur cluster binding
D9842_RS09965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9842_RS09970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9842_RS09975	COG2068	MobA-Related Protein
D9842_RS09980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9842_RS09985	COG0402	S-adenosylhomocysteine deaminase activity
D9842_RS09990	COG0561	phosphatase activity
D9842_RS09995	COG2720	vancomycin resistance protein
D9842_RS10000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9842_RS10005	COG0436	Aminotransferase
D9842_RS10015	COG2814	Major facilitator Superfamily
D9842_RS10020	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D9842_RS10025	COG0778	Nitroreductase
D9842_RS10050	COG1063	alcohol dehydrogenase
D9842_RS10065	COG5002	protein histidine kinase activity
D9842_RS10070	COG0493	'glutamate synthase
D9842_RS10075	COG0067	glutamate synthase
D9842_RS10075	COG0070	glutamate synthase
D9842_RS10075	COG0069	glutamate synthase activity
D9842_RS10080	COG0583	DNA-binding transcription factor activity
D9842_RS10090	COG0584	glycerophosphoryl diester phosphodiesterase
D9842_RS10095	COG0778	Nitroreductase
D9842_RS10110	COG3973	AAA domain
D9842_RS10115	COG4085	toxin activity
D9842_RS10115	COG1525	nuclease
D9842_RS10115	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS10140	COG2017	converts alpha-aldose to the beta-anomer
D9842_RS10145	COG0596	Alpha beta hydrolase
D9842_RS10160	COG2340	Cysteine-rich secretory protein family
D9842_RS10170	COG1830	Aldolase
D9842_RS10205	COG2323	membrane
D9842_RS10210	COG2311	Membrane
D9842_RS10225	COG2112	serine threonine protein kinase
D9842_RS10230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9842_RS10245	COG2404	hydrolase activity, acting on ester bonds
D9842_RS10250	COG1247	-acetyltransferase
D9842_RS10265	COG2211	Major facilitator Superfamily
D9842_RS10270	COG1657	PFAM Prenyltransferase squalene oxidase
D9842_RS10275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9842_RS10280	COG0733	neurotransmitter:sodium symporter activity
D9842_RS10285	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9842_RS10295	COG4548	von Willebrand factor, type A
D9842_RS10300	COG0714	Associated with various cellular activities
D9842_RS10305	COG2032	superoxide dismutase activity
D9842_RS10310	COG0791	NLP P60 protein
D9842_RS10310	COG1388	LysM domain
D9842_RS10320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9842_RS10325	COG0534	Mate efflux family protein
D9842_RS10330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9842_RS10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9842_RS10345	COG2962	Rard protein
D9842_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS10365	COG1733	regulation of RNA biosynthetic process
D9842_RS10370	COG0778	Nitroreductase
D9842_RS10375	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9842_RS10380	COG3409	Peptidoglycan-binding domain 1 protein
D9842_RS10380	COG0793	Belongs to the peptidase S41A family
D9842_RS10390	COG2226	methyltransferase
D9842_RS10400	COG3663	DNA glycosylase
D9842_RS10405	COG1876	peptidase activity
D9842_RS10420	COG0671	phosphoesterase, PA-phosphatase related
D9842_RS10430	COG0789	Transcriptional regulator
D9842_RS10440	COG0217	transcriptional regulatory protein
D9842_RS10450	COG0386	Belongs to the glutathione peroxidase family
D9842_RS10455	COG4326	sporulation control protein
D9842_RS10460	COG3064	Membrane
D9842_RS10460	COG0515	serine threonine protein kinase
D9842_RS10460	COG4991	sh3 domain protein
D9842_RS10490	COG4479	Belongs to the UPF0346 family
D9842_RS10495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9842_RS10505	COG0346	lactoylglutathione lyase activity
D9842_RS10510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9842_RS10510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9842_RS10515	COG1846	Transcriptional regulator
D9842_RS10530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9842_RS10540	COG4698	Protein conserved in bacteria
D9842_RS10545	COG2755	lipolytic protein G-D-S-L family
D9842_RS10550	COG1999	signal sequence binding
D9842_RS10570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9842_RS10580	COG1272	protein, Hemolysin III
D9842_RS10590	COG2608	mercury ion transmembrane transporter activity
D9842_RS10595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9842_RS10620	COG2521	methyltransferase
D9842_RS10620	COG2136	Putative SAM-dependent methyltransferase
D9842_RS10630	COG0129	dihydroxy-acid dehydratase activity
D9842_RS10635	COG1413	lyase activity
D9842_RS10640	COG1418	mRNA catabolic process
D9842_RS10650	COG0386	Belongs to the glutathione peroxidase family
D9842_RS10665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9842_RS10670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9842_RS10675	COG1988	membrane-bound metal-dependent
D9842_RS10690	COG1278	Cold shock
D9842_RS10715	COG0328	RNA-DNA hybrid ribonuclease activity
D9842_RS10735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9842_RS10750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9842_RS10755	COG1755	Isoprenylcysteine carboxyl methyltransferase
D9842_RS10760	COG3424	synthase
D9842_RS10805	COG1278	Cold shock
D9842_RS10815	COG2233	PERMEase
D9842_RS10820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9842_RS10825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D9842_RS10830	COG1199	ATP-dependent helicase activity
D9842_RS10845	COG0116	Belongs to the methyltransferase superfamily
D9842_RS10870	COG3359	exonuclease
D9842_RS10875	COG1111	helicase
D9842_RS10875	COG1205	dead DEAH box helicase
D9842_RS10925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9842_RS10925	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9842_RS10935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9842_RS10940	COG3935	DnaD domain protein
D9842_RS10945	COG0017	Asparaginyl-tRNA synthetase
D9842_RS10960	COG1199	ATP-dependent helicase activity
D9842_RS10960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9842_RS10965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9842_RS10970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9842_RS10975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9842_RS10985	COG0617	tRNA 3'-terminal CCA addition
D9842_RS10990	COG0438	transferase activity, transferring glycosyl groups
D9842_RS10995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9842_RS11000	COG1803	Methylglyoxal synthase
D9842_RS11005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9842_RS11010	COG1694	Mazg nucleotide pyrophosphohydrolase
D9842_RS11015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9842_RS11025	COG4347	Protein of unknown function (DUF1405)
D9842_RS11030	COG2010	Cytochrome c
D9842_RS11030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9842_RS11035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9842_RS11040	COG0723	plastoquinol--plastocyanin reductase activity
D9842_RS11050	COG5582	Belongs to the UPF0302 family
D9842_RS11055	COG0457	Tetratricopeptide repeat
D9842_RS11070	COG0287	Prephenate dehydrogenase
D9842_RS11075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9842_RS11080	COG0159	tryptophan synthase activity
D9842_RS11085	COG0133	tryptophan synthase activity
D9842_RS11090	COG0135	phosphoribosylanthranilate isomerase activity
D9842_RS11095	COG0134	indole-3-glycerol-phosphate synthase activity
D9842_RS11100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9842_RS11105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9842_RS11110	COG4401	Chorismate mutase type I
D9842_RS11115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9842_RS11120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9842_RS11125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9842_RS11130	COG0105	UTP biosynthetic process
D9842_RS11135	COG0142	geranyltranstransferase activity
D9842_RS11140	COG2226	methyltransferase
D9842_RS11145	COG0142	geranyltranstransferase activity
D9842_RS11155	COG0302	gtp cyclohydrolase
D9842_RS11160	COG0776	regulation of translation
D9842_RS11165	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9842_RS11185	COG1160	GTP binding
D9842_RS11210	COG1304	FMN binding
D9842_RS11215	COG0539	negative regulation of cytoplasmic translation
D9842_RS11220	COG0204	Acyl-transferase
D9842_RS11225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9842_RS11230	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D9842_RS11235	COG2959	enzyme of heme biosynthesis
D9842_RS11240	COG3409	Peptidoglycan-binding domain 1 protein
D9842_RS11240	COG3773	Cell wall hydrolase
D9842_RS11245	COG2339	peptidase activity
D9842_RS11250	COG0252	asparaginase activity
D9842_RS11255	COG0492	ferredoxin-NADP+ reductase activity
D9842_RS11260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9842_RS11265	COG4862	establishment of competence for transformation
D9842_RS11275	COG1408	metallophosphoesterase
D9842_RS11290	COG1266	CAAX protease self-immunity
D9842_RS11295	COG0514	ATP-dependent DNA helicase (RecQ)
D9842_RS11300	COG4955	Helix-turn-helix domain
D9842_RS11305	COG1141	Ferredoxin
D9842_RS11310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D9842_RS11315	COG0739	heme binding
D9842_RS11325	COG1595	DNA-templated transcription, initiation
D9842_RS11330	COG2096	Adenosyltransferase
D9842_RS11335	COG5002	protein histidine kinase activity
D9842_RS11340	COG0745	RESPONSE REGULATOR receiver
D9842_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9842_RS11350	COG1333	cytochrome c biogenesis protein
D9842_RS11355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS11360	COG1187	pseudouridine synthase activity
D9842_RS11365	COG0700	Nucleoside recognition
D9842_RS11370	COG2715	membrane protein required for spore maturation
D9842_RS11375	COG1686	Belongs to the peptidase S11 family
D9842_RS11385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9842_RS11400	COG1547	Domain of unknown function (DUF309)
D9842_RS11415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9842_RS11415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9842_RS11420	COG0307	riboflavin synthase, alpha
D9842_RS11425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9842_RS11430	COG4086	secreted protein
D9842_RS11435	COG0019	diaminopimelate decarboxylase activity
D9842_RS11440	COG0697	spore germination
D9842_RS11455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9842_RS11475	COG1191	sigma factor activity
D9842_RS11480	COG2172	sigma factor antagonist activity
D9842_RS11485	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS11490	COG1686	Belongs to the peptidase S11 family
D9842_RS11515	COG4974	Belongs to the 'phage' integrase family
D9842_RS11525	COG0735	belongs to the Fur family
D9842_RS11530	COG1300	Membrane
D9842_RS11540	COG1379	DNA repair
D9842_RS11545	COG0494	nUDIX hydrolase
D9842_RS11555	COG0667	Aldo Keto reductase
D9842_RS11565	COG1073	alpha beta
D9842_RS11570	COG1115	amino acid carrier protein
D9842_RS11650	COG4918	Iron-sulphur cluster biosynthesis
D9842_RS11660	COG2755	lipolytic protein G-D-S-L family
D9842_RS11665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9842_RS11680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS11685	COG0300	oxidoreductase activity
D9842_RS11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS11695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9842_RS11715	COG1902	pentaerythritol trinitrate reductase activity
D9842_RS11720	COG1234	tRNA 3'-trailer cleavage
D9842_RS11725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9842_RS11735	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS11740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9842_RS11745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9842_RS11795	COG2340	Cysteine-rich secretory protein family
D9842_RS11800	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9842_RS11805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9842_RS11810	COG0346	lactoylglutathione lyase activity
D9842_RS11815	COG1376	ErfK ybiS ycfS ynhG family protein
D9842_RS11820	COG4129	membrane
D9842_RS11825	COG1126	abc transporter atp-binding protein
D9842_RS11830	COG0765	amino acid transport
D9842_RS11835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9842_RS11850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9842_RS11850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9842_RS11855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9842_RS11860	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9842_RS11865	COG0022	dehydrogenase e1 component
D9842_RS11870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9842_RS11875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9842_RS11880	COG3426	butyrate kinase activity
D9842_RS11890	COG0280	phosphate acetyltransferase
D9842_RS11895	COG3829	transcription factor binding
D9842_RS11895	COG3290	protein histidine kinase activity
D9842_RS11905	COG0584	glycerophosphoryl diester phosphodiesterase
D9842_RS11910	COG3093	addiction module antidote protein HigA
D9842_RS11915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9842_RS11925	COG0745	RESPONSE REGULATOR receiver
D9842_RS11935	COG0750	zinc metalloprotease
D9842_RS11940	COG0497	DNA recombination
D9842_RS11945	COG1438	arginine binding
D9842_RS11950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D9842_RS11955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9842_RS11965	COG0142	geranyltranstransferase activity
D9842_RS11970	COG1722	exodeoxyribonuclease VII activity
D9842_RS11975	COG1570	exodeoxyribonuclease VII activity
D9842_RS11980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9842_RS11990	COG1302	Protein conserved in bacteria
D9842_RS11995	COG0439	Biotin carboxylase
D9842_RS12000	COG0511	ligase activity, forming carbon-carbon bonds
D9842_RS12040	COG3854	ATPases associated with a variety of cellular activities
D9842_RS12050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9842_RS12055	COG0006	proline dipeptidase activity
D9842_RS12060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9842_RS12070	COG3872	metal-dependent enzyme
D9842_RS12080	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9842_RS12085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS12090	COG0601	transmembrane transport
D9842_RS12095	COG0747	negative chemotaxis
D9842_RS12100	COG4608	Belongs to the ABC transporter superfamily
D9842_RS12105	COG0444	Belongs to the ABC transporter superfamily
D9842_RS12110	COG1321	iron dependent repressor
D9842_RS12115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9842_RS12120	COG2852	Protein conserved in bacteria
D9842_RS12130	COG0095	Lipoate-protein ligase
D9842_RS12135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS12145	COG4536	flavin adenine dinucleotide binding
D9842_RS12155	COG0840	transmembrane signaling receptor activity
D9842_RS12170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9842_RS12175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9842_RS12180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9842_RS12195	COG1396	sequence-specific DNA binding
D9842_RS12220	COG1132	(ABC) transporter
D9842_RS12235	COG1408	metallophosphoesterase
D9842_RS12250	COG1132	(ABC) transporter
D9842_RS12265	COG0367	asparagine synthase
D9842_RS12270	COG0463	Glycosyl transferase, family 2
D9842_RS12275	COG0438	transferase activity, transferring glycosyl groups
D9842_RS12280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9842_RS12295	COG1696	Membrane protein involved in D-alanine export
D9842_RS12305	COG1083	cytidylyl-transferase
D9842_RS12315	COG2089	acid synthase
D9842_RS12330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D9842_RS12335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9842_RS12335	COG0517	IMP dehydrogenase activity
D9842_RS12340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D9842_RS12365	COG1216	Glycosyl transferase, family 2
D9842_RS12370	COG1132	(ABC) transporter
D9842_RS12390	COG1396	sequence-specific DNA binding
D9842_RS12395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9842_RS12400	COG0110	maltose O-acetyltransferase activity
D9842_RS12405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9842_RS12415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9842_RS12425	COG0489	protein tyrosine kinase activity
D9842_RS12435	COG1396	sequence-specific DNA binding
D9842_RS12490	COG4537	Required for transformation and DNA binding
D9842_RS12495	COG1459	type II secretion system
D9842_RS12500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9842_RS12510	COG1393	Belongs to the ArsC family
D9842_RS12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS12530	COG0011	TIGRFAM Protein of
D9842_RS12545	COG1368	sulfuric ester hydrolase activity
D9842_RS12550	COG1940	carbohydrate kinase activity
D9842_RS12555	COG4483	Protein conserved in bacteria
D9842_RS12560	COG1966	Carbon starvation protein
D9842_RS12565	COG0697	spore germination
D9842_RS12575	COG0705	Rhomboid family
D9842_RS12575	COG0457	Tetratricopeptide repeat
D9842_RS12585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9842_RS12590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9842_RS12615	COG0704	Plays a role in the regulation of phosphate uptake
D9842_RS12620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9842_RS12625	COG0581	inorganic phosphate transmembrane transporter activity
D9842_RS12630	COG0573	inorganic phosphate transmembrane transporter activity
D9842_RS12635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9842_RS12640	COG0477	Major facilitator Superfamily
D9842_RS12650	COG2839	Protein conserved in bacteria
D9842_RS12660	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9842_RS12665	COG5521	maltodextrose utilization protein MalA
D9842_RS12670	COG1388	LysM domain
D9842_RS12675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9842_RS12685	COG4709	membrane
D9842_RS12690	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D9842_RS12695	COG0735	belongs to the Fur family
D9842_RS12700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9842_RS12705	COG1121	(ABC) transporter
D9842_RS12715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D9842_RS12720	COG0513	Belongs to the DEAD box helicase family
D9842_RS12735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9842_RS12740	COG2384	SAM-dependent methyltransferase
D9842_RS12745	COG2010	Cytochrome c
D9842_RS12755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9842_RS12760	COG0358	DNA primase activity
D9842_RS12765	COG1671	Belongs to the UPF0178 family
D9842_RS12770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9842_RS12775	COG0517	IMP dehydrogenase activity
D9842_RS12780	COG0751	glycine-tRNA ligase activity
D9842_RS12790	COG1381	Involved in DNA repair and RecF pathway recombination
D9842_RS12800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9842_RS12805	COG0295	cytidine deaminase activity
D9842_RS12810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D9842_RS12815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9842_RS12820	COG1480	7TM receptor with intracellular HD hydrolase
D9842_RS12825	COG1702	phosphate starvation-inducible protein PhoH
D9842_RS12850	COG4864	UPF0365 protein
D9842_RS12855	COG1030	water channel activity
D9842_RS12860	COG1610	YqeY-like protein
D9842_RS12865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9842_RS12870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9842_RS12875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9842_RS12880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9842_RS12885	COG2264	protein methyltransferase activity
D9842_RS12890	COG0484	heat shock protein binding
D9842_RS12895	COG0443	Heat shock 70 kDa protein
D9842_RS12900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9842_RS12905	COG1420	regulation of RNA biosynthetic process
D9842_RS12910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9842_RS12915	COG0481	GTPase activity
D9842_RS12925	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS12930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D9842_RS12935	COG0268	Binds directly to 16S ribosomal RNA
D9842_RS12940	COG1466	dna polymerase III delta subunit
D9842_RS12950	COG2333	competence protein COMEC
D9842_RS12950	COG0658	competence protein
D9842_RS12955	COG2131	deaminase
D9842_RS12960	COG1596	polysaccharide export
D9842_RS12960	COG1555	photosystem II stabilization
D9842_RS12965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9842_RS12970	COG2226	methyltransferase
D9842_RS12975	COG0799	negative regulation of ribosome biogenesis
D9842_RS12980	COG1713	HD superfamily hydrolase involved in NAD metabolism
D9842_RS12985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9842_RS12990	COG1534	Rna-binding protein
D9842_RS12995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9842_RS13000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9842_RS13005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D9842_RS13030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9842_RS13045	COG0768	penicillin binding
D9842_RS13050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9842_RS13055	COG0572	uridine kinase
D9842_RS13060	COG0826	peptidase U32
D9842_RS13065	COG0826	peptidase U32
D9842_RS13070	COG4122	O-methyltransferase activity
D9842_RS13080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9842_RS13085	COG3906	Belongs to the UPF0473 family
D9842_RS13095	COG4472	Bacterial protein of unknown function (DUF965)
D9842_RS13100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9842_RS13105	COG0628	permease
D9842_RS13120	COG3881	PFAM PRC-barrel domain
D9842_RS13125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9842_RS13135	COG0482	sulfurtransferase activity
D9842_RS13140	COG1104	cysteine desulfurase activity
D9842_RS13145	COG1959	2 iron, 2 sulfur cluster binding
D9842_RS13150	COG2364	Membrane
D9842_RS13155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9842_RS13165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9842_RS13175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9842_RS13180	COG0124	histidyl-tRNA synthetase
D9842_RS13185	COG4991	sh3 domain protein
D9842_RS13185	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS13185	COG3103	Sh3 type 3 domain protein
D9842_RS13190	COG1490	D-aminoacyl-tRNA deacylase activity
D9842_RS13195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9842_RS13200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9842_RS13205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D9842_RS13205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D9842_RS13210	COG5416	Lipopolysaccharide assembly protein A domain
D9842_RS13215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9842_RS13220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9842_RS13220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9842_RS13230	COG2244	polysaccharide biosynthetic process
D9842_RS13235	COG2323	membrane
D9842_RS13250	COG1862	Preprotein translocase
D9842_RS13260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9842_RS13270	COG2255	four-way junction helicase activity
D9842_RS13275	COG0632	four-way junction helicase activity
D9842_RS13290	COG1388	LysM domain
D9842_RS13300	COG0157	Belongs to the NadC ModD family
D9842_RS13305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9842_RS13310	COG1104	cysteine desulfurase activity
D9842_RS13315	COG1827	regulation of RNA biosynthetic process
D9842_RS13320	COG0077	Prephenate dehydratase
D9842_RS13325	COG4492	Belongs to the UPF0735 family
D9842_RS13335	COG3290	protein histidine kinase activity
D9842_RS13345	COG2868	ribosomal protein
D9842_RS13350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9842_RS13360	COG1994	Peptidase M50
D9842_RS13365	COG0739	heme binding
D9842_RS13370	COG2894	cell division
D9842_RS13375	COG0850	regulation of cytokinetic process
D9842_RS13380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D9842_RS13385	COG1792	Involved in formation and maintenance of cell shape
D9842_RS13390	COG1077	Cell shape determining protein MreB Mrl
D9842_RS13395	COG2003	Belongs to the UPF0758 family
D9842_RS13425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D9842_RS13445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9842_RS13490	COG0285	dihydrofolate synthase activity
D9842_RS13495	COG0525	valine-tRNA ligase activity
D9842_RS13505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9842_RS13510	COG1388	LysM domain
D9842_RS13510	COG1388	LysM domain
D9842_RS13515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9842_RS13520	COG0113	porphobilinogen synthase activity
D9842_RS13525	COG1587	Uroporphyrinogen-III synthase
D9842_RS13530	COG0181	hydroxymethylbilane synthase activity
D9842_RS13535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9842_RS13555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9842_RS13560	COG0470	DNA polymerase III
D9842_RS13560	COG1067	ATP-dependent peptidase activity
D9842_RS13565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9842_RS13570	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9842_RS13575	COG1477	protein flavinylation
D9842_RS13575	COG0457	Tetratricopeptide repeat
D9842_RS13580	COG0066	3-isopropylmalate dehydratase activity
D9842_RS13585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9842_RS13590	COG0473	3-isopropylmalate dehydrogenase activity
D9842_RS13595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9842_RS13600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9842_RS13605	COG0440	acetolactate synthase activity
D9842_RS13610	COG0028	Belongs to the TPP enzyme family
D9842_RS13615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9842_RS13625	COG0622	Phosphoesterase
D9842_RS13630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9842_RS13635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9842_RS13640	COG5401	PFAM Sporulation and spore germination
D9842_RS13650	COG1846	Transcriptional regulator
D9842_RS13655	COG2197	response regulator
D9842_RS13660	COG0824	Thioesterase
D9842_RS13665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D9842_RS13670	COG1053	succinate dehydrogenase
D9842_RS13675	COG2009	succinate dehydrogenase
D9842_RS13680	COG1719	4-vinyl reductase, 4VR
D9842_RS13695	COG3118	belongs to the thioredoxin family
D9842_RS13700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9842_RS13705	COG2086	electron transfer activity
D9842_RS13710	COG1024	Enoyl-CoA hydratase
D9842_RS13715	COG1309	transcriptional regulator
D9842_RS13720	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS13725	COG3766	membrane
D9842_RS13730	COG1193	negative regulation of DNA recombination
D9842_RS13735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9842_RS13735	COG1796	DNA polymerase
D9842_RS13740	COG1286	toxin biosynthetic process
D9842_RS13745	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D9842_RS13750	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9842_RS13755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9842_RS13755	COG0072	phenylalanine-tRNA ligase activity
D9842_RS13760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9842_RS13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9842_RS13775	COG1363	Peptidase, m42
D9842_RS13790	COG0398	Pfam SNARE associated Golgi protein
D9842_RS13795	COG3326	Membrane
D9842_RS13800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9842_RS13810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9842_RS13815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9842_RS13825	COG1484	DNA-dependent DNA replication
D9842_RS13830	COG3611	Membrane attachment protein
D9842_RS13845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9842_RS13850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9842_RS13860	COG1971	Probably functions as a manganese efflux pump
D9842_RS13865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9842_RS13870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9842_RS13870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9842_RS13875	COG0330	HflC and HflK could
D9842_RS13880	COG0330	HflC and HflK could
D9842_RS13885	COG5002	protein histidine kinase activity
D9842_RS13890	COG0745	RESPONSE REGULATOR receiver
D9842_RS13905	COG0538	isocitrate dehydrogenase activity
D9842_RS13910	COG0372	Belongs to the citrate synthase family
D9842_RS13915	COG2707	UPF0756 membrane protein
D9842_RS13920	COG0628	permease
D9842_RS13925	COG3030	protein affecting phage T7 exclusion by the F plasmid
D9842_RS13930	COG0469	pyruvate kinase activity
D9842_RS13935	COG0205	6-phosphofructokinase activity
D9842_RS13940	COG0825	malonyl-CoA metabolic process
D9842_RS13945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9842_RS13950	COG1725	Transcriptional regulator
D9842_RS13955	COG0281	malic enzyme
D9842_RS13960	COG0587	DNA-directed DNA polymerase activity
D9842_RS13980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D9842_RS13990	COG4109	DRTGG domain
D9842_RS14000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D9842_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS14015	COG0165	Argininosuccinate lyase
D9842_RS14020	COG0137	argininosuccinate synthase activity
D9842_RS14030	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9842_RS14045	COG0827	DNA restriction-modification system
D9842_RS14050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D9842_RS14055	COG3874	Sporulation protein YtfJ
D9842_RS14065	COG1714	RDD family
D9842_RS14070	COG0616	signal peptide processing
D9842_RS14075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9842_RS14080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D9842_RS14085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9842_RS14095	COG0301	tRNA thio-modification
D9842_RS14100	COG1104	cysteine desulfurase activity
D9842_RS14105	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D9842_RS14110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9842_RS14115	COG1309	transcriptional regulator
D9842_RS14120	COG1956	GAF domain-containing protein
D9842_RS14125	COG2203	Gaf domain
D9842_RS14125	COG2199	diguanylate cyclase activity
D9842_RS14130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9842_RS14135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9842_RS14145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9842_RS14150	COG0454	-acetyltransferase
D9842_RS14155	COG0517	IMP dehydrogenase activity
D9842_RS14160	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9842_RS14170	COG1609	Transcriptional regulator
D9842_RS14175	COG1605	Chorismate mutase
D9842_RS14175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D9842_RS14180	COG0849	cell division
D9842_RS14185	COG3118	belongs to the thioredoxin family
D9842_RS14190	COG4980	gas vesicle protein
D9842_RS14195	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D9842_RS14200	COG2309	aminopeptidase activity
D9842_RS14205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9842_RS14215	COG1674	ftsk spoiiie
D9842_RS14220	COG4848	Belongs to the UPF0354 family
D9842_RS14225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS14240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9842_RS14260	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D9842_RS14265	COG1363	Peptidase, m42
D9842_RS14270	COG5584	Small secreted protein
D9842_RS14275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS14280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9842_RS14290	COG0510	thiamine kinase activity
D9842_RS14295	COG1523	belongs to the glycosyl hydrolase 13 family
D9842_RS14300	COG1597	lipid kinase activity
D9842_RS14310	COG1346	cytolysis
D9842_RS14315	COG1380	Effector of murein hydrolase LrgA
D9842_RS14325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9842_RS14330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9842_RS14335	COG2252	PERMEase
D9842_RS14340	COG0024	Methionine aminopeptidase
D9842_RS14345	COG4473	ABC transporter
D9842_RS14350	COG1131	(ABC) transporter
D9842_RS14355	COG1349	DNA-binding transcription factor activity
D9842_RS14360	COG1187	pseudouridine synthase activity
D9842_RS14365	COG2244	polysaccharide biosynthetic process
D9842_RS14370	COG2081	HI0933 family
D9842_RS14380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS14385	COG0495	leucyl-tRNA aminoacylation
D9842_RS14390	COG2814	Major facilitator Superfamily
D9842_RS14395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS14400	COG0577	efflux transmembrane transporter activity
D9842_RS14405	COG1136	(ABC) transporter
D9842_RS14415	COG1131	(ABC) transporter
D9842_RS14420	COG1725	Transcriptional regulator
D9842_RS14440	COG1242	4 iron, 4 sulfur cluster binding
D9842_RS14445	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D9842_RS14455	COG2267	carboxylic ester hydrolase activity
D9842_RS14460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9842_RS14465	COG0671	phosphoesterase, PA-phosphatase related
D9842_RS14470	COG0438	transferase activity, transferring glycosyl groups
D9842_RS14485	COG0745	RESPONSE REGULATOR receiver
D9842_RS14490	COG5002	protein histidine kinase activity
D9842_RS14495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9842_RS14500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D9842_RS14515	COG1506	peptidase
D9842_RS14520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9842_RS14525	COG1116	anion transmembrane transporter activity
D9842_RS14530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9842_RS14535	COG0494	nUDIX hydrolase
D9842_RS14550	COG0783	Belongs to the Dps family
D9842_RS14565	COG0701	Predicted permease
D9842_RS14570	COG1469	GTP cyclohydrolase I activity
D9842_RS14575	COG1854	S-ribosylhomocysteine lyase activity
D9842_RS14580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9842_RS14585	COG0288	reversible hydration of carbon dioxide
D9842_RS14600	COG1271	oxidase subunit
D9842_RS14605	COG1294	oxidase, subunit
D9842_RS14615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9842_RS14620	COG1321	iron dependent repressor
D9842_RS14620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9842_RS14625	COG1121	(ABC) transporter
D9842_RS14635	COG4948	Mandelate Racemase Muconate Lactonizing
D9842_RS14640	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS14645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9842_RS14650	COG0596	Alpha beta hydrolase
D9842_RS14655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D9842_RS14660	COG1169	isochorismate synthase
D9842_RS14665	COG1575	Belongs to the MenA family. Type 1 subfamily
D9842_RS14670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9842_RS14675	COG0385	Bile acid
D9842_RS14690	COG0058	SHG alpha-glucan phosphorylase activity
D9842_RS14695	COG0297	glycogen (starch) synthase activity
D9842_RS14700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9842_RS14705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9842_RS14840	COG3859	Proton-coupled thiamine transporter YuaJ
D9842_RS14860	COG2318	DinB family
D9842_RS14865	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS14875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D9842_RS14880	COG3386	PFAM SMP-30 Gluconolaconase
D9842_RS14885	COG1132	(ABC) transporter
D9842_RS14900	COG4876	unkown
D9842_RS14910	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS14910	COG1525	nuclease
D9842_RS14910	COG4085	toxin activity
D9842_RS14935	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS14955	COG3403	YqcI/YcgG family
D9842_RS14960	COG1335	isochorismatase
D9842_RS14965	COG0697	spore germination
D9842_RS14975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9842_RS14980	COG0010	Belongs to the arginase family
D9842_RS14990	COG1116	anion transmembrane transporter activity
D9842_RS15020	COG1054	Belongs to the UPF0176 family
D9842_RS15035	COG3584	3D domain protein
D9842_RS15035	COG1388	LysM domain
D9842_RS15040	COG2207	Transcriptional regulator
D9842_RS15040	COG3708	Transcriptional regulator
D9842_RS15050	COG5522	Integral membrane protein (intg_mem_TP0381)
D9842_RS15060	COG0861	Integral membrane protein TerC family
D9842_RS15070	COG3239	Fatty acid desaturase
D9842_RS15075	COG4585	Histidine kinase
D9842_RS15080	COG2197	response regulator
D9842_RS15095	COG1388	LysM domain
D9842_RS15095	COG0791	NLP P60 protein
D9842_RS15115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9842_RS15120	COG1309	transcriptional regulator
D9842_RS15125	COG3706	GGDEF domain
D9842_RS15130	COG1309	transcriptional regulator
D9842_RS15140	COG1227	inorganic diphosphatase activity
D9842_RS15145	COG2070	2-Nitropropane dioxygenase
D9842_RS15150	COG1301	dicarboxylic acid transport
D9842_RS15155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9842_RS15160	COG3290	protein histidine kinase activity
D9842_RS15170	COG2264	protein methyltransferase activity
D9842_RS15180	COG0667	Aldo Keto reductase
D9842_RS15185	COG1733	regulation of RNA biosynthetic process
D9842_RS15200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9842_RS15205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9842_RS15210	COG4585	Histidine kinase
D9842_RS15225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9842_RS15230	COG1278	Cold shock
D9842_RS15245	COG1033	growth of symbiont in host cell
D9842_RS15245	COG2409	Drug exporters of the RND superfamily
D9842_RS15250	COG1846	Transcriptional regulator
D9842_RS15270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS15285	COG0432	Pfam Uncharacterised protein family UPF0047
D9842_RS15290	COG5002	protein histidine kinase activity
D9842_RS15295	COG0745	RESPONSE REGULATOR receiver
D9842_RS15320	COG2738	Putative neutral zinc metallopeptidase
D9842_RS15330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9842_RS15340	COG0166	Belongs to the GPI family
D9842_RS15345	COG1979	alcohol dehydrogenase
D9842_RS15350	COG2155	Conserved Protein
D9842_RS15355	COG1098	S1 RNA binding domain
D9842_RS15370	COG0436	Aminotransferase
D9842_RS15375	COG1522	sequence-specific DNA binding
D9842_RS15380	COG2267	carboxylic ester hydrolase activity
D9842_RS15395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D9842_RS15400	COG2205	protein histidine kinase activity
D9842_RS15405	COG2032	superoxide dismutase activity
D9842_RS15420	COG5018	Exonuclease
D9842_RS15425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9842_RS15430	COG3011	Protein conserved in bacteria
D9842_RS15445	COG2111	Na H antiporter
D9842_RS15445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9842_RS15450	COG2111	Na H antiporter
D9842_RS15455	COG1006	Multisubunit Na H antiporter MnhC subunit
D9842_RS15460	COG0651	ATP synthesis coupled electron transport
D9842_RS15465	COG1863	multisubunit Na H antiporter MnhE subunit
D9842_RS15470	COG2212	antiporter activity
D9842_RS15475	COG1320	monovalent cation:proton antiporter activity
D9842_RS15480	COG2050	protein possibly involved in aromatic compounds catabolism
D9842_RS15485	COG4585	Histidine kinase
D9842_RS15490	COG0142	geranyltranstransferase activity
D9842_RS15505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9842_RS15510	COG2368	4-hydroxyphenylacetate
D9842_RS15525	COG0628	permease
D9842_RS15530	COG1253	flavin adenine dinucleotide binding
D9842_RS15535	COG2738	Putative neutral zinc metallopeptidase
D9842_RS15540	COG0789	Transcriptional regulator
D9842_RS15550	COG1418	mRNA catabolic process
D9842_RS15560	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS15565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9842_RS15565	COG2508	Transcriptional regulator
D9842_RS15570	COG0686	Belongs to the AlaDH PNT family
D9842_RS15585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9842_RS15590	COG1268	BioY protein
D9842_RS15600	COG2056	Na+-H+ antiporter family
D9842_RS15610	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D9842_RS15615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9842_RS15620	COG3584	3D domain protein
D9842_RS15635	COG1252	NADH dehydrogenase
D9842_RS15645	COG0316	Belongs to the HesB IscA family
D9842_RS15650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9842_RS15665	COG1252	NADH dehydrogenase
D9842_RS15670	COG4837	Protein of unknown function (DUF1462)
D9842_RS15675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9842_RS15680	COG0083	homoserine kinase activity
D9842_RS15685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9842_RS15690	COG0460	homoserine dehydrogenase
D9842_RS15695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9842_RS15705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9842_RS15710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9842_RS15715	COG0647	UMP catabolic process
D9842_RS15720	COG2445	Protein of unknown function DUF86
D9842_RS15725	COG5001	Diguanylate cyclase
D9842_RS15740	COG4470	Protein conserved in bacteria
D9842_RS15750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9842_RS15755	COG0739	heme binding
D9842_RS15765	COG0733	neurotransmitter:sodium symporter activity
D9842_RS15770	COG1757	Na H antiporter
D9842_RS15780	COG3377	Domain of unknown function (DUF1805)
D9842_RS15785	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS15790	COG1801	Protein of unknown function DUF72
D9842_RS15795	COG0719	Fe-S assembly protein
D9842_RS15800	COG0822	iron-sulfur transferase activity
D9842_RS15805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9842_RS15810	COG0719	Fe-S assembly protein
D9842_RS15815	COG0396	ATPase activity
D9842_RS15820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9842_RS15825	COG1464	Belongs to the NlpA lipoprotein family
D9842_RS15830	COG2011	ABC-type metal ion transport system permease component
D9842_RS15835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9842_RS15840	COG2873	o-acetylhomoserine
D9842_RS15850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS15855	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D9842_RS15865	COG0509	glycine decarboxylation via glycine cleavage system
D9842_RS15870	COG1393	Belongs to the ArsC family
D9842_RS15875	COG1960	acyl-CoA dehydrogenase activity
D9842_RS15880	COG0183	Belongs to the thiolase family
D9842_RS15885	COG1024	Enoyl-CoA hydratase
D9842_RS15885	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS15905	COG5577	PFAM Coat F domain
D9842_RS15920	COG1120	ATPase activity
D9842_RS15925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS15930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS15935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9842_RS15945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9842_RS15950	COG0569	domain protein
D9842_RS15960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9842_RS15965	COG1686	Belongs to the peptidase S11 family
D9842_RS15975	COG2076	Multidrug Resistance protein
D9842_RS15980	COG2076	Multidrug Resistance protein
D9842_RS15990	COG3546	catalase activity
D9842_RS16000	COG4191	Histidine kinase
D9842_RS16005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9842_RS16010	COG0745	RESPONSE REGULATOR receiver
D9842_RS16015	COG2770	Histidine kinase
D9842_RS16015	COG2205	protein histidine kinase activity
D9842_RS16020	COG0114	fumarate hydratase activity
D9842_RS16025	COG2814	Major facilitator Superfamily
D9842_RS16025	COG0477	Major facilitator Superfamily
D9842_RS16030	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9842_RS16035	COG1193	negative regulation of DNA recombination
D9842_RS16060	COG5002	protein histidine kinase activity
D9842_RS16070	COG1842	Phage shock protein A
D9842_RS16075	COG2608	mercury ion transmembrane transporter activity
D9842_RS16085	COG2814	Major facilitator Superfamily
D9842_RS16090	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9842_RS16090	COG1388	LysM domain
D9842_RS16100	COG0840	transmembrane signaling receptor activity
D9842_RS16105	COG0840	transmembrane signaling receptor activity
D9842_RS16110	COG4213	ABC transporter substrate-binding protein
D9842_RS16115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9842_RS16125	COG0693	protein deglycase activity
D9842_RS16130	COG2390	Transcriptional regulator
D9842_RS16135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9842_RS16145	COG3852	Histidine kinase
D9842_RS16175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9842_RS16180	COG0523	cobalamin synthesis protein
D9842_RS16185	COG3883	PFAM NLP P60 protein
D9842_RS16185	COG0791	NLP P60 protein
D9842_RS16190	COG4335	DNA alkylation repair
D9842_RS16195	COG2197	response regulator
D9842_RS16200	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS16205	COG2201	protein-glutamate methylesterase activity
D9842_RS16210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9842_RS16215	COG0840	transmembrane signaling receptor activity
D9842_RS16220	COG2198	Histidine kinase
D9842_RS16220	COG0643	Histidine kinase
D9842_RS16225	COG0784	Response regulator, receiver
D9842_RS16225	COG0835	chemotaxis
D9842_RS16230	COG2201	protein-glutamate methylesterase activity
D9842_RS16245	COG0784	Response regulator, receiver
D9842_RS16245	COG4191	Histidine kinase
D9842_RS16255	COG3290	protein histidine kinase activity
D9842_RS16255	COG0840	transmembrane signaling receptor activity
D9842_RS16270	COG2208	phosphoserine phosphatase activity
D9842_RS16280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9842_RS16285	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D9842_RS16305	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS16310	COG2814	Major facilitator Superfamily
D9842_RS16315	COG1968	undecaprenyl-diphosphatase activity
D9842_RS16325	COG0346	lactoylglutathione lyase activity
D9842_RS16330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9842_RS16335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9842_RS16345	COG3711	transcriptional antiterminator
D9842_RS16350	COG2723	6-phospho-beta-galactosidase activity
D9842_RS16355	COG1263	PTS System
D9842_RS16355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9842_RS16355	COG2190	(PTS) system
D9842_RS16365	COG0784	Response regulator, receiver
D9842_RS16365	COG2205	protein histidine kinase activity
D9842_RS16365	COG5002	protein histidine kinase activity
D9842_RS16370	COG3279	Response regulator of the LytR AlgR family
D9842_RS16380	COG1917	Cupin 2, conserved barrel domain protein
D9842_RS16380	COG2207	Transcriptional regulator
D9842_RS16385	COG0697	spore germination
D9842_RS16390	COG4989	oxidoreductase activity
D9842_RS16440	COG1686	Belongs to the peptidase S11 family
D9842_RS16450	COG2723	6-phospho-beta-galactosidase activity
D9842_RS16485	COG0579	oxidoreductase
D9842_RS16490	COG0842	Transport permease protein
D9842_RS16495	COG0842	Transport permease protein
D9842_RS16495	COG1511	domain protein
D9842_RS16500	COG1131	(ABC) transporter
D9842_RS16505	COG2197	response regulator
D9842_RS16510	COG4585	Histidine kinase
D9842_RS16520	COG0657	acetylesterase activity
D9842_RS16525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9842_RS16545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS16565	COG2233	PERMEase
D9842_RS16570	COG2267	carboxylic ester hydrolase activity
D9842_RS16580	COG1522	sequence-specific DNA binding
D9842_RS16585	COG3813	Protein conserved in bacteria
D9842_RS16590	COG1335	isochorismatase
D9842_RS16600	COG2226	methyltransferase
D9842_RS16625	COG0840	transmembrane signaling receptor activity
D9842_RS16645	COG4565	transcriptional regulatory protein
D9842_RS16650	COG3290	protein histidine kinase activity
D9842_RS16720	COG1196	nuclear chromosome segregation
D9842_RS16740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9842_RS16745	COG0557	exoribonuclease II activity
D9842_RS16750	COG1647	Serine aminopeptidase, S33
D9842_RS16755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9842_RS16760	COG3842	ATPase activity
D9842_RS16765	COG0395	ABC-type sugar transport system, permease component
D9842_RS16775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D9842_RS16785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9842_RS16785	COG1796	DNA polymerase
D9842_RS16795	COG0148	phosphopyruvate hydratase activity
D9842_RS16815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9842_RS16830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9842_RS16855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS16860	COG1481	regulation of sporulation
D9842_RS16865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D9842_RS16870	COG1660	Displays ATPase and GTPase activities
D9842_RS16875	COG1051	belongs to the nudix hydrolase family
D9842_RS16880	COG0492	ferredoxin-NADP+ reductase activity
D9842_RS16885	COG0457	Tetratricopeptide repeat
D9842_RS16895	COG0140	phosphoribosyl-ATP diphosphatase activity
D9842_RS16895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9842_RS16900	COG0107	imidazoleglycerol-phosphate synthase activity
D9842_RS16905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9842_RS16910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9842_RS16915	COG0131	Imidazoleglycerol-phosphate dehydratase
D9842_RS16920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9842_RS16925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9842_RS16930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9842_RS16935	COG0110	maltose O-acetyltransferase activity
D9842_RS16940	COG0546	phosphoglycolate phosphatase activity
D9842_RS16945	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D9842_RS16950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9842_RS16955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D9842_RS16965	COG2247	cell wall binding repeat
D9842_RS16965	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS16970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9842_RS16975	COG1950	PFAM Membrane protein of
D9842_RS16980	COG1983	PspC domain protein
D9842_RS16985	COG3595	metallopeptidase activity
D9842_RS17005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9842_RS17015	COG4897	Protein conserved in bacteria
D9842_RS17020	COG0456	acetyltransferase
D9842_RS17025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9842_RS17030	COG0306	phosphate transporter
D9842_RS17035	COG1392	Phosphate transport regulator
D9842_RS17040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9842_RS17045	COG1309	transcriptional regulator
D9842_RS17055	COG1482	cell wall glycoprotein biosynthetic process
D9842_RS17060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9842_RS17080	COG3711	transcriptional antiterminator
D9842_RS17090	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9842_RS17100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9842_RS17115	COG3731	PTS system glucitol sorbitol-specific IIA component
D9842_RS17120	COG3732	PTS system glucitol sorbitol-specific
D9842_RS17185	COG0840	transmembrane signaling receptor activity
D9842_RS17190	COG4191	Histidine kinase
D9842_RS17200	COG0840	transmembrane signaling receptor activity
D9842_RS17200	COG3290	protein histidine kinase activity
D9842_RS17210	COG0288	reversible hydration of carbon dioxide
D9842_RS17220	COG5609	conserved protein (DUF2294)
D9842_RS17230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9842_RS17240	COG0598	Magnesium transport protein CorA
D9842_RS17255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9842_RS17270	COG1280	lysine exporter protein (LysE YggA)
D9842_RS17285	COG1393	Belongs to the ArsC family
D9842_RS17290	COG2814	Major facilitator Superfamily
D9842_RS17315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D9842_RS17320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9842_RS17330	COG1082	Xylose isomerase domain protein TIM barrel
D9842_RS17340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9842_RS17345	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS17370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS17375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS17380	COG2329	Antibiotic biosynthesis monooxygenase
D9842_RS17395	COG1522	sequence-specific DNA binding
D9842_RS17400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D9842_RS17415	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS17430	COG0659	secondary active sulfate transmembrane transporter activity
D9842_RS17435	COG0659	secondary active sulfate transmembrane transporter activity
D9842_RS17440	COG0589	response to stress
D9842_RS17460	COG0395	ABC-type sugar transport system, permease component
D9842_RS17465	COG4209	transmembrane transport
D9842_RS17470	COG1653	transport
D9842_RS17475	COG4753	response regulator
D9842_RS17475	COG2207	Transcriptional regulator
D9842_RS17480	COG3275	phosphorelay sensor kinase activity
D9842_RS17495	COG1522	sequence-specific DNA binding
D9842_RS17500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9842_RS17510	COG0793	Belongs to the peptidase S41A family
D9842_RS17510	COG3409	Peptidoglycan-binding domain 1 protein
D9842_RS17515	COG0739	heme binding
D9842_RS17520	COG2177	Part of the ABC transporter FtsEX involved in
D9842_RS17525	COG2884	Cell division ATP-binding protein ftsE
D9842_RS17530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D9842_RS17530	COG2199	diguanylate cyclase activity
D9842_RS17535	COG2010	Cytochrome c
D9842_RS17540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9842_RS17550	COG0653	protein targeting
D9842_RS17555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9842_RS17560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9842_RS17575	COG1516	flagellar protein fliS
D9842_RS17580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9842_RS17580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9842_RS17585	COG1334	flagellar protein FlaG
D9842_RS17595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9842_RS17610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9842_RS17615	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D9842_RS17625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9842_RS17630	COG1256	bacterial-type flagellum assembly
D9842_RS17630	COG4786	Flagellar basal body rod
D9842_RS17635	COG3418	PFAM FlgN family protein
D9842_RS17650	COG1040	competence protein
D9842_RS17660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D9842_RS17670	COG1307	EDD domain protein, DegV family
D9842_RS17675	COG2197	response regulator
D9842_RS17680	COG4585	Histidine kinase
D9842_RS17685	COG1739	Uncharacterized protein family UPF0029
D9842_RS17690	COG1316	TRANSCRIPTIONal
D9842_RS17695	COG2247	cell wall binding repeat
D9842_RS17695	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS17705	COG2385	sporulation resulting in formation of a cellular spore
D9842_RS17705	COG2247	cell wall binding repeat
D9842_RS17720	COG0482	sulfurtransferase activity
D9842_RS17730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9842_RS17755	COG0653	protein targeting
D9842_RS17770	COG1388	LysM domain
D9842_RS17770	COG0791	NLP P60 protein
D9842_RS17795	COG3858	chitin binding
D9842_RS17820	COG1785	Belongs to the alkaline phosphatase family
D9842_RS17880	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS17885	COG1376	ErfK ybiS ycfS ynhG family protein
D9842_RS17905	COG2247	cell wall binding repeat
D9842_RS17905	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS17920	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS17935	COG0840	transmembrane signaling receptor activity
D9842_RS17940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9842_RS17955	COG2197	response regulator
D9842_RS17960	COG4585	Histidine kinase
D9842_RS17970	COG3227	Zinc metalloprotease (Elastase)
D9842_RS17995	COG3279	Response regulator of the LytR AlgR family
D9842_RS18000	COG0784	Response regulator, receiver
D9842_RS18000	COG2198	Histidine kinase
D9842_RS18000	COG5002	protein histidine kinase activity
D9842_RS18010	COG0840	transmembrane signaling receptor activity
D9842_RS18085	COG5444	nuclease activity
D9842_RS18180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9842_RS18190	COG1378	Sugar-specific transcriptional regulator TrmB
D9842_RS18205	COG0402	S-adenosylhomocysteine deaminase activity
D9842_RS18210	COG0840	transmembrane signaling receptor activity
D9842_RS18240	COG1501	Belongs to the glycosyl hydrolase 31 family
D9842_RS18245	COG4977	sequence-specific DNA binding
D9842_RS18250	COG0840	transmembrane signaling receptor activity
D9842_RS18275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9842_RS18305	COG0606	chelatase, subunit chli
D9842_RS18360	COG0840	transmembrane signaling receptor activity
D9842_RS18420	COG2340	Cysteine-rich secretory protein family
D9842_RS18440	COG0577	efflux transmembrane transporter activity
D9842_RS18445	COG1136	(ABC) transporter
D9842_RS18445	COG0577	efflux transmembrane transporter activity
D9842_RS18460	COG5002	protein histidine kinase activity
D9842_RS18460	COG3850	Histidine kinase
D9842_RS18465	COG0745	RESPONSE REGULATOR receiver
D9842_RS18485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9842_RS18490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9842_RS18495	COG1215	transferase activity, transferring glycosyl groups
D9842_RS18500	COG0438	transferase activity, transferring glycosyl groups
D9842_RS18510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9842_RS18515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9842_RS18520	COG1316	TRANSCRIPTIONal
D9842_RS18560	COG3853	Toxic anion resistance protein (TelA)
D9842_RS18565	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D9842_RS18570	COG1405	negative regulation of cell septum assembly
D9842_RS18570	COG3012	SEC-C Motif Domain Protein
D9842_RS18575	COG1114	Component of the transport system for branched-chain amino acids
D9842_RS18580	COG1114	Component of the transport system for branched-chain amino acids
D9842_RS18595	COG5001	Diguanylate cyclase
D9842_RS18595	COG3300	MHYT domain
D9842_RS18665	COG1757	Na H antiporter
D9842_RS18675	COG2186	Transcriptional regulator
D9842_RS18690	COG0395	ABC-type sugar transport system, permease component
D9842_RS18740	COG1175	transmembrane transport
D9842_RS18750	COG2207	Transcriptional regulator
D9842_RS18750	COG4753	response regulator
D9842_RS18755	COG2972	Histidine kinase
D9842_RS18765	COG4715	Zinc finger, swim domain protein
D9842_RS18770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9842_RS18785	COG0629	single-stranded DNA binding
D9842_RS18795	COG3620	sequence-specific DNA binding
D9842_RS18805	COG3546	catalase activity
D9842_RS18835	COG4786	Flagellar basal body rod
D9842_RS18840	COG4786	Flagellar basal body rod
D9842_RS18855	COG1077	Cell shape determining protein MreB Mrl
D9842_RS18860	COG1609	Transcriptional regulator
D9842_RS18865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9842_RS18885	COG0739	heme binding
D9842_RS18895	COG2385	sporulation resulting in formation of a cellular spore
D9842_RS18905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9842_RS18915	COG4836	Membrane
D9842_RS18930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9842_RS18935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9842_RS18940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9842_RS18945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9842_RS18950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9842_RS18955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9842_RS18960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9842_RS18965	COG0356	it plays a direct role in the translocation of protons across the membrane
D9842_RS18980	COG1404	Belongs to the peptidase S8 family
D9842_RS18985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9842_RS18990	COG5002	protein histidine kinase activity
D9842_RS18995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9842_RS19005	COG0698	ribose 5-phosphate isomerase
D9842_RS19010	COG0840	transmembrane signaling receptor activity
D9842_RS19025	COG0701	Predicted permease
D9842_RS19030	COG0523	cobalamin synthesis protein
D9842_RS19040	COG1971	Probably functions as a manganese efflux pump
D9842_RS19045	COG0009	L-threonylcarbamoyladenylate synthase
D9842_RS19050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9842_RS19075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9842_RS19080	COG0346	lactoylglutathione lyase activity
D9842_RS19085	COG4608	Belongs to the ABC transporter superfamily
D9842_RS19090	COG0444	Belongs to the ABC transporter superfamily
D9842_RS19095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS19100	COG0601	transmembrane transport
D9842_RS19105	COG0747	negative chemotaxis
D9842_RS19110	COG0789	Transcriptional regulator
D9842_RS19120	COG1435	thymidine kinase activity
D9842_RS19130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9842_RS19135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9842_RS19140	COG0191	fructose-bisphosphate aldolase activity
D9842_RS19145	COG2204	response regulator
D9842_RS19150	COG4821	SIS domain
D9842_RS19155	COG1414	Transcriptional regulator
D9842_RS19160	COG0439	Biotin carboxylase
D9842_RS19165	COG0511	ligase activity, forming carbon-carbon bonds
D9842_RS19170	COG1984	allophanate hydrolase subunit 2
D9842_RS19175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9842_RS19180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9842_RS19185	COG1914	H( )-stimulated, divalent metal cation uptake system
D9842_RS19190	COG3547	Transposase (IS116 IS110 IS902 family)
D9842_RS19195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9842_RS19200	COG0840	transmembrane signaling receptor activity
D9842_RS19215	COG0395	ABC-type sugar transport system, permease component
D9842_RS19220	COG1175	transmembrane transport
D9842_RS19225	COG1653	transport
D9842_RS19230	COG0504	CTP synthase activity
D9842_RS19235	COG3343	RNA polymerase activity
D9842_RS19240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9842_RS19240	COG1703	isobutyryl-CoA mutase activity
D9842_RS19240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D9842_RS19250	COG1960	acyl-CoA dehydrogenase activity
D9842_RS19255	COG1960	acyl-CoA dehydrogenase activity
D9842_RS19260	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9842_RS19265	COG0183	Belongs to the thiolase family
D9842_RS19270	COG2181	nitrate reductase activity
D9842_RS19270	COG0247	lactate metabolic process
D9842_RS19275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9842_RS19290	COG0018	arginyl-trna synthetase
D9842_RS19295	COG4506	Protein conserved in bacteria
D9842_RS19305	COG2340	Cysteine-rich secretory protein family
D9842_RS19310	COG0010	Belongs to the arginase family
D9842_RS19315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9842_RS19320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9842_RS19330	COG1994	Peptidase M50
D9842_RS19335	COG3465	dGTPase activity
D9842_RS19340	COG1078	dGTPase activity
D9842_RS19345	COG4844	belongs to the
D9842_RS19355	COG2217	Heavy metal translocating P-type atpase
D9842_RS19375	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D9842_RS19380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS19390	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS19395	COG0280	phosphate acetyltransferase
D9842_RS19400	COG3253	May function as heme-dependent peroxidase
D9842_RS19415	COG2363	Small membrane protein
D9842_RS19435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9842_RS19440	COG1216	Glycosyl transferase, family 2
D9842_RS19450	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D9842_RS19455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9842_RS19460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D9842_RS19465	COG2207	Transcriptional regulator
D9842_RS19480	COG0492	ferredoxin-NADP+ reductase activity
D9842_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS19500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS19510	COG0778	Nitroreductase
D9842_RS19515	COG0477	Major facilitator Superfamily
D9842_RS19525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9842_RS19535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9842_RS19540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9842_RS19555	COG0346	lactoylglutathione lyase activity
D9842_RS19560	COG0551	DNA topoisomerase type I activity
D9842_RS19560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9842_RS19565	COG0488	(ABC) transporter
D9842_RS19575	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS19580	COG2197	response regulator
D9842_RS19585	COG4585	Histidine kinase
D9842_RS19605	COG0723	plastoquinol--plastocyanin reductase activity
D9842_RS19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9842_RS19615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9842_RS19615	COG1587	Uroporphyrinogen-III synthase
D9842_RS19620	COG2146	nitrite reductase [NAD(P)H] activity
D9842_RS19625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9842_RS19635	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS19640	COG0243	molybdopterin cofactor binding
D9842_RS19645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9842_RS19650	COG2223	nitrite transmembrane transporter activity
D9842_RS19655	COG0281	malic enzyme
D9842_RS19660	COG1846	Transcriptional regulator
D9842_RS19665	COG2814	Major facilitator Superfamily
D9842_RS19670	COG0667	Aldo Keto reductase
D9842_RS19680	COG1587	Uroporphyrinogen-III synthase
D9842_RS19685	COG0788	formyltetrahydrofolate deformylase activity
D9842_RS19695	COG2966	Psort location CytoplasmicMembrane, score
D9842_RS19710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9842_RS19725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9842_RS19725	COG1263	PTS System
D9842_RS19730	COG0366	Alpha amylase catalytic
D9842_RS19735	COG2188	Transcriptional regulator
D9842_RS19740	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9842_RS19745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9842_RS19755	COG2270	Major facilitator Superfamily
D9842_RS19760	COG2323	membrane
D9842_RS19765	COG1132	(ABC) transporter
D9842_RS19770	COG1132	(ABC) transporter
D9842_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS19790	COG0492	ferredoxin-NADP+ reductase activity
D9842_RS19795	COG1120	ATPase activity
D9842_RS19810	COG1902	pentaerythritol trinitrate reductase activity
D9842_RS19820	COG0745	RESPONSE REGULATOR receiver
D9842_RS19825	COG2205	protein histidine kinase activity
D9842_RS19830	COG1136	(ABC) transporter
D9842_RS19835	COG0577	efflux transmembrane transporter activity
D9842_RS19860	COG0737	Belongs to the 5'-nucleotidase family
D9842_RS19865	COG1620	l-lactate permease
D9842_RS19870	COG0039	L-malate dehydrogenase activity
D9842_RS19875	COG0561	phosphatase activity
D9842_RS19885	COG3775	system Galactitol-specific IIC component
D9842_RS19890	COG3414	Phosphotransferase system galactitol-specific IIB component
D9842_RS19895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS19895	COG2213	PTS system mannitol-specific
D9842_RS19905	COG3414	Phosphotransferase system galactitol-specific IIB component
D9842_RS19910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS19915	COG0823	Involved in the tonB-independent uptake of proteins
D9842_RS19920	COG0542	response to heat
D9842_RS19925	COG0450	alkyl hydroperoxide reductase
D9842_RS19930	COG3634	alkyl hydroperoxide reductase activity
D9842_RS19935	COG0322	excinuclease ABC activity
D9842_RS19945	COG3507	Belongs to the glycosyl hydrolase 43 family
D9842_RS19950	COG1132	(ABC) transporter
D9842_RS19960	COG4191	Histidine kinase
D9842_RS19965	COG2040	homocysteine
D9842_RS19970	COG1126	abc transporter atp-binding protein
D9842_RS19975	COG0765	amino acid transport
D9842_RS19980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9842_RS19990	COG1388	LysM domain
D9842_RS19990	COG0741	lytic transglycosylase activity
D9842_RS20000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS20005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS20010	COG1120	ATPase activity
D9842_RS20050	COG2197	response regulator
D9842_RS20055	COG2199	diguanylate cyclase activity
D9842_RS20060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9842_RS20070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9842_RS20075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9842_RS20080	COG4853	Protein conserved in bacteria
D9842_RS20085	COG4863	YycH protein
D9842_RS20090	COG5002	protein histidine kinase activity
D9842_RS20095	COG0745	RESPONSE REGULATOR receiver
D9842_RS20100	COG1196	nuclear chromosome segregation
D9842_RS20100	COG0741	lytic transglycosylase activity
D9842_RS20100	COG0739	heme binding
D9842_RS20130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9842_RS20135	COG0305	Participates in initiation and elongation during chromosome replication
D9842_RS20140	COG0359	binds to the 23S rRNA
D9842_RS20145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D9842_RS20150	COG4241	membrane
D9842_RS20155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9842_RS20160	COG0629	single-stranded DNA binding
D9842_RS20165	COG0360	Binds together with S18 to 16S ribosomal RNA
D9842_RS20180	COG0012	GTP binding
D9842_RS20185	COG0243	molybdopterin cofactor binding
D9842_RS20190	COG4481	Protein conserved in bacteria
D9842_RS20195	COG0668	transmembrane transport
D9842_RS20200	COG3949	Membrane
D9842_RS20210	COG1811	Na channel or pump
D9842_RS20215	COG1475	DNA binding
D9842_RS20220	COG1192	Involved in chromosome partitioning
D9842_RS20225	COG1475	DNA binding
D9842_RS20230	COG0357	Ribosomal RNA small subunit methyltransferase G
D9842_RS20235	COG0445	tRNA wobble uridine modification
D9842_RS20240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9842_RS20245	COG1847	R3H domain protein
D9842_RS20255	COG0594	ribonuclease P activity
D9842_RS20260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9842_RS20265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9842_RS20270	COG0592	DNA-directed DNA polymerase activity
D9842_RS20275	COG2501	S4 domain
D9842_RS20280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9842_RS20290	COG0187	DNA topoisomerase II activity
D9842_RS20295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9842_RS20335	COG0516	GMP reductase activity
D9842_RS20335	COG0517	IMP dehydrogenase activity
D9842_RS20340	COG1686	Belongs to the peptidase S11 family
D9842_RS20345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D9842_RS20350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D9842_RS20355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9842_RS20365	COG1428	Deoxynucleoside kinase
D9842_RS20370	COG1428	Deoxynucleoside kinase
D9842_RS20375	COG3858	chitin binding
D9842_RS20375	COG1388	LysM domain
D9842_RS20380	COG1335	isochorismatase
D9842_RS20385	COG0590	tRNA wobble adenosine to inosine editing
D9842_RS20395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9842_RS20400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9842_RS20405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9842_RS20450	COG1982	Orn Lys Arg decarboxylase major
D9842_RS20455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9842_RS20460	COG3870	Protein conserved in bacteria
D9842_RS20465	COG1728	Protein conserved in bacteria
D9842_RS20470	COG0470	DNA polymerase III
D9842_RS20475	COG1774	PSP1 C-terminal conserved region
D9842_RS20480	COG4467	Involved in initiation control of chromosome replication
D9842_RS20485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D9842_RS20490	COG2827	Endonuclease containing a URI domain
D9842_RS20495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9842_RS20500	COG2002	toxin-antitoxin pair type II binding
D9842_RS20510	COG0084	hydrolase, TatD family'
D9842_RS20515	COG3583	domain protein
D9842_RS20515	COG3584	3D domain protein
D9842_RS20525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9842_RS20535	COG4466	Protein conserved in bacteria
D9842_RS20550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9842_RS20555	COG0251	oxidation-reduction process
D9842_RS20560	COG2088	sporulation resulting in formation of a cellular spore
D9842_RS20565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9842_RS20570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9842_RS20580	COG0193	aminoacyl-tRNA hydrolase activity
D9842_RS20590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9842_RS20595	COG2002	toxin-antitoxin pair type II binding
D9842_RS20600	COG2244	polysaccharide biosynthetic process
D9842_RS20605	COG3956	TIGRFAM MazG family protein
D9842_RS20610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9842_RS20630	COG1098	S1 RNA binding domain
D9842_RS20645	COG2208	phosphoserine phosphatase activity
D9842_RS20650	COG2304	oxidoreductase activity
D9842_RS20655	COG0515	serine threonine protein kinase
D9842_RS20660	COG0037	tRNA processing
D9842_RS20665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D9842_RS20670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9842_RS20675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9842_RS20680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9842_RS20685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9842_RS20690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9842_RS20695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9842_RS20700	COG0512	Glutamine amidotransferase of anthranilate synthase
D9842_RS20705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9842_RS20710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9842_RS20715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9842_RS20720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9842_RS20725	COG1396	sequence-specific DNA binding
D9842_RS20730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9842_RS20820	COG1285	pathogenesis
D9842_RS20830	COG3880	PFAM UvrB UvrC protein
D9842_RS20835	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D9842_RS20840	COG0542	response to heat
D9842_RS20845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D9842_RS20850	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D9842_RS20855	COG4956	integral membrane protein (PIN domain superfamily)
D9842_RS20860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D9842_RS20865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D9842_RS20870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9842_RS20875	COG1045	serine acetyltransferase
D9842_RS20880	COG0215	cysteine-tRNA ligase activity
D9842_RS20885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D9842_RS20890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9842_RS20895	COG3688	RNA-binding protein containing a PIN domain
D9842_RS20910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9842_RS20915	COG0250	Participates in transcription elongation, termination and antitermination
D9842_RS20920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9842_RS20925	COG0081	regulation of translation
D9842_RS20930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9842_RS20935	COG0222	ribosome binding
D9842_RS20940	COG2813	Specifically methylates the guanine in position
D9842_RS20945	COG0085	RNA polymerase activity
D9842_RS20950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9842_RS20955	COG1358	cellular component organization or biogenesis
D9842_RS20965	COG0049	tRNA binding
D9842_RS20970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9842_RS20975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9842_RS20980	COG0051	transcription antitermination factor activity, RNA binding
D9842_RS20985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9842_RS20990	COG0088	Forms part of the polypeptide exit tunnel
D9842_RS20995	COG0089	rRNA binding
D9842_RS21000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9842_RS21005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9842_RS21010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9842_RS21015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9842_RS21020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9842_RS21025	COG0255	Belongs to the universal ribosomal protein uL29 family
D9842_RS21030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9842_RS21035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9842_RS21040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9842_RS21050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9842_RS21055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9842_RS21075	COG1841	ribosomal large subunit assembly
D9842_RS21080	COG0200	Binds to the 23S rRNA
D9842_RS21085	COG0201	protein transport
D9842_RS21090	COG0563	adenylate kinase activity
D9842_RS21095	COG0024	Methionine aminopeptidase
D9842_RS21105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9842_RS21110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9842_RS21115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9842_RS21130	COG0203	ribosomal protein L17
D9842_RS21135	COG1122	ATPase activity
D9842_RS21140	COG1122	ATPase activity
D9842_RS21145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D9842_RS21150	COG0101	tRNA pseudouridine synthase activity
D9842_RS21155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9842_RS21160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9842_RS21170	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS21175	COG0489	protein tyrosine kinase activity
D9842_RS21185	COG2194	sulfuric ester hydrolase activity
D9842_RS21190	COG0726	polysaccharide deacetylase
D9842_RS21265	COG1595	DNA-templated transcription, initiation
D9842_RS21270	COG5662	AntiSigma factor
D9842_RS21275	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9842_RS21280	COG4856	YbbR-like protein
D9842_RS21285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9842_RS21295	COG1309	transcriptional regulator
D9842_RS21305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D9842_RS21315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9842_RS21320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D9842_RS21335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9842_RS21345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9842_RS21345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9842_RS21360	COG0697	spore germination
D9842_RS21370	COG1280	lysine exporter protein (LysE YggA)
D9842_RS21375	COG2226	methyltransferase
D9842_RS21380	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D9842_RS21395	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9842_RS21400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9842_RS21410	COG0513	Belongs to the DEAD box helicase family
D9842_RS21415	COG2311	Membrane
D9842_RS21420	COG0745	RESPONSE REGULATOR receiver
D9842_RS21425	COG2205	protein histidine kinase activity
D9842_RS21430	COG4294	response to UV
D9842_RS21435	COG3402	PFAM membrane-flanked domain
D9842_RS21440	COG3428	Bacterial PH domain
D9842_RS21445	COG0705	Rhomboid family
D9842_RS21450	COG0736	holo-[acyl-carrier-protein] synthase activity
D9842_RS21455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9842_RS21460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9842_RS21465	COG0864	Transcriptional regulator
D9842_RS21470	COG2337	Toxic component of a toxin-antitoxin (TA) module
D9842_RS21475	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS21480	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS21485	COG2172	sigma factor antagonist activity
D9842_RS21490	COG2208	phosphoserine phosphatase activity
D9842_RS21495	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS21505	COG1191	sigma factor activity
D9842_RS21510	COG2208	phosphoserine phosphatase activity
D9842_RS21515	COG2183	response to ionizing radiation
D9842_RS21525	COG3091	SprT-like family
D9842_RS21610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9842_RS21615	COG0802	atpase or kinase
D9842_RS21620	COG1214	PFAM Peptidase M22, glycoprotease
D9842_RS21625	COG0456	acetyltransferase
D9842_RS21635	COG0488	(ABC) transporter
D9842_RS21640	COG0315	cyclic pyranopterin monophosphate synthase activity
D9842_RS21645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D9842_RS21650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9842_RS21655	COG0805	protein transport
D9842_RS21665	COG1266	CAAX protease self-immunity
D9842_RS21675	COG0459	protein refolding
D9842_RS21705	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D9842_RS21715	COG1510	regulation of RNA biosynthetic process
D9842_RS21720	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS21725	COG1175	transmembrane transport
D9842_RS21730	COG0395	ABC-type sugar transport system, permease component
D9842_RS21735	COG5578	integral membrane protein
D9842_RS21740	COG1653	transport
D9842_RS21755	COG3940	Belongs to the glycosyl hydrolase 43 family
D9842_RS21760	COG2723	6-phospho-beta-galactosidase activity
D9842_RS21775	COG3290	protein histidine kinase activity
D9842_RS21780	COG4565	transcriptional regulatory protein
D9842_RS21785	COG3181	Tripartite tricarboxylate transporter family receptor
D9842_RS21810	COG0714	Associated with various cellular activities
D9842_RS21815	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D9842_RS21820	COG1305	Transglutaminase-like
D9842_RS21825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9842_RS21825	COG0519	Catalyzes the synthesis of GMP from XMP
D9842_RS21830	COG2252	PERMEase
D9842_RS21855	COG0463	Glycosyl transferase, family 2
D9842_RS21880	COG0584	glycerophosphoryl diester phosphodiesterase
D9842_RS21915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D9842_RS21920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9842_RS21925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9842_RS21935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9842_RS21940	COG0047	phosphoribosylformylglycinamidine synthase activity
D9842_RS21945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9842_RS21950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9842_RS21955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9842_RS21960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9842_RS21965	COG0138	bifunctional purine biosynthesis protein purh
D9842_RS21970	COG0151	Belongs to the GarS family
D9842_RS21980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9842_RS21985	COG1470	cell adhesion involved in biofilm formation
D9842_RS21990	COG4496	protein, YerC YecD
D9842_RS21995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D9842_RS22000	COG0210	DNA helicase
D9842_RS22010	COG4851	CamS sex pheromone cAM373 precursor
D9842_RS22015	COG1012	belongs to the aldehyde dehydrogenase family
D9842_RS22025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9842_RS22035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9842_RS22040	COG0154	amidase activity
D9842_RS22050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9842_RS22055	COG1597	lipid kinase activity
D9842_RS22060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9842_RS22070	COG0154	amidase activity
D9842_RS22075	COG2271	Major facilitator Superfamily
D9842_RS22110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9842_RS22115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9842_RS22120	COG1335	isochorismatase
D9842_RS22130	COG0784	Response regulator, receiver
D9842_RS22130	COG5002	protein histidine kinase activity
D9842_RS22135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9842_RS22140	COG4191	Histidine kinase
D9842_RS22145	COG2116	formate transmembrane transporter activity
D9842_RS22150	COG0596	Alpha beta hydrolase
D9842_RS22155	COG2208	phosphoserine phosphatase activity
D9842_RS22160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D9842_RS22170	COG1595	DNA-templated transcription, initiation
D9842_RS22175	COG4807	Protein conserved in bacteria
D9842_RS22185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9842_RS22190	COG3104	oligopeptide transport
D9842_RS22195	COG1874	Beta-galactosidase
D9842_RS22200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D9842_RS22210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D9842_RS22215	COG1309	transcriptional regulator
D9842_RS22220	COG0477	Major facilitator Superfamily
D9842_RS22225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9842_RS22250	COG4191	Histidine kinase
D9842_RS22275	COG1309	transcriptional regulator
D9842_RS22285	COG5002	protein histidine kinase activity
D9842_RS22290	COG5582	Belongs to the UPF0302 family
D9842_RS22305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9842_RS22310	COG0667	Aldo Keto reductase
D9842_RS22330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D9842_RS22335	COG0697	spore germination
D9842_RS22345	COG0561	phosphatase activity
D9842_RS22350	COG1349	DNA-binding transcription factor activity
D9842_RS22355	COG3290	protein histidine kinase activity
D9842_RS22360	COG4565	transcriptional regulatory protein
D9842_RS22365	COG3493	citrate carrier protein
D9842_RS22375	COG0730	response to heat
D9842_RS22380	COG0166	Belongs to the GPI family
D9842_RS22395	COG3852	Histidine kinase
D9842_RS22415	COG1129	ABC transporter
D9842_RS22420	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9842_RS22430	COG0765	amino acid transport
D9842_RS22440	COG0527	aspartate kinase activity
D9842_RS22445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9842_RS22475	COG2205	protein histidine kinase activity
D9842_RS22480	COG1388	LysM domain
D9842_RS22480	COG3584	3D domain protein
D9842_RS22485	COG2223	nitrite transmembrane transporter activity
D9842_RS22490	COG1668	transmembrane transport
D9842_RS22495	COG4555	ABC transporter
D9842_RS22500	COG3279	Response regulator of the LytR AlgR family
D9842_RS22515	COG1132	(ABC) transporter
D9842_RS22520	COG1132	(ABC) transporter
D9842_RS22530	COG3842	ATPase activity
D9842_RS22535	COG1175	transmembrane transport
D9842_RS22550	COG0584	glycerophosphoryl diester phosphodiesterase
D9842_RS22555	COG1115	amino acid carrier protein
D9842_RS22565	COG1131	(ABC) transporter
D9842_RS22570	COG1725	Transcriptional regulator
D9842_RS22575	COG0840	transmembrane signaling receptor activity
D9842_RS22580	COG0488	(ABC) transporter
D9842_RS22590	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D9842_RS22620	COG1073	alpha beta
D9842_RS22625	COG4608	Belongs to the ABC transporter superfamily
D9842_RS22635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS22640	COG0601	transmembrane transport
D9842_RS22655	COG0693	protein deglycase activity
D9842_RS22660	COG4840	Belongs to the UPF0435 family
D9842_RS22665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9842_RS22675	COG1295	ribonuclease BN
D9842_RS22685	COG0477	Major facilitator Superfamily
D9842_RS22695	COG3871	stress protein (general stress protein 26)
D9842_RS22700	COG2364	Membrane
D9842_RS22710	COG0668	transmembrane transport
D9842_RS22715	COG0535	radical SAM domain protein
D9842_RS22740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D9842_RS22745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9842_RS22765	COG5002	protein histidine kinase activity
D9842_RS22935	COG2124	cytochrome p450
D9842_RS22940	COG1231	oxidoreductase activity
D9842_RS22945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9842_RS22955	COG1609	Transcriptional regulator
D9842_RS22970	COG0673	inositol 2-dehydrogenase activity
D9842_RS22980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9842_RS22990	COG0513	Belongs to the DEAD box helicase family
D9842_RS23020	COG1090	epimerase
D9842_RS23025	COG2137	regulation of response to DNA damage stimulus
D9842_RS23045	COG1988	membrane-bound metal-dependent
D9842_RS23050	COG1194	a g-specific adenine glycosylase
D9842_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS23075	COG3557	Belongs to the UPF0374 family
D9842_RS23080	COG1132	(ABC) transporter
D9842_RS23085	COG4129	membrane
D9842_RS23095	COG4555	ABC transporter
D9842_RS23115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9842_RS23120	COG2309	aminopeptidase activity
D9842_RS23130	COG0735	belongs to the Fur family
D9842_RS23295	COG2115	Belongs to the xylose isomerase family
D9842_RS23300	COG1070	Carbohydrate kinase
D9842_RS23315	COG2972	Histidine kinase
D9842_RS23320	COG2207	Transcriptional regulator
D9842_RS23320	COG4753	response regulator
D9842_RS23325	COG1653	transport
D9842_RS23330	COG1175	transmembrane transport
D9842_RS23335	COG0395	ABC-type sugar transport system, permease component
D9842_RS23350	COG1366	Belongs to the anti-sigma-factor antagonist family
D9842_RS23355	COG0477	Major facilitator Superfamily
D9842_RS23360	COG1309	transcriptional regulator
D9842_RS23365	COG3852	Histidine kinase
D9842_RS23385	COG3382	B3 4 domain protein
D9842_RS23400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9842_RS23405	COG2766	serine protein kinase
D9842_RS23415	COG1253	flavin adenine dinucleotide binding
D9842_RS23420	COG1653	transport
D9842_RS23425	COG1175	transmembrane transport
D9842_RS23430	COG0395	ABC-type sugar transport system, permease component
D9842_RS23440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9842_RS23450	COG2814	Major facilitator Superfamily
D9842_RS23465	COG4191	Histidine kinase
D9842_RS23475	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9842_RS23495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9842_RS23500	COG4605	iron ion homeostasis
D9842_RS23505	COG4604	ABC transporter, ATP-binding protein
D9842_RS23510	COG4607	ABC-type enterochelin transport system periplasmic component
D9842_RS23515	COG2249	NAD(P)H dehydrogenase (quinone) activity
D9842_RS23520	COG3764	Sortase (surface protein transpeptidase)
D9842_RS23525	COG0805	protein transport
D9842_RS23530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9842_RS23540	COG0564	pseudouridine synthase activity
D9842_RS23560	COG0517	IMP dehydrogenase activity
D9842_RS23565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9842_RS23565	COG3153	acetyltransferase
D9842_RS23570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9842_RS23575	COG2203	Gaf domain
D9842_RS23575	COG4585	Histidine kinase
D9842_RS23580	COG2197	response regulator
D9842_RS23585	COG0431	NADPH-dependent FMN reductase
D9842_RS23595	COG2866	Carboxypeptidase
D9842_RS23605	COG1959	2 iron, 2 sulfur cluster binding
D9842_RS23615	COG2719	SpoVR family
D9842_RS23620	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9842_RS23625	COG1937	Protein conserved in bacteria
D9842_RS23630	COG0425	Belongs to the sulfur carrier protein TusA family
D9842_RS23635	COG2210	Belongs to the sulfur carrier protein TusA family
D9842_RS23645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS23645	COG0425	Belongs to the sulfur carrier protein TusA family
D9842_RS23650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS23650	COG0425	Belongs to the sulfur carrier protein TusA family
D9842_RS23655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9842_RS23655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9842_RS23660	COG0730	response to heat
D9842_RS23665	COG0640	Transcriptional regulator
D9842_RS23670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9842_RS23675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9842_RS23680	COG0346	lactoylglutathione lyase activity
D9842_RS23685	COG0640	Transcriptional regulator
D9842_RS23700	COG0561	phosphatase activity
D9842_RS23705	COG0673	inositol 2-dehydrogenase activity
D9842_RS23710	COG0753	catalase activity
D9842_RS23750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9842_RS23755	COG0586	Pfam SNARE associated Golgi protein
D9842_RS23770	COG1011	Hydrolase
D9842_RS23780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9842_RS23785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9842_RS23790	COG1757	Na H antiporter
D9842_RS23795	COG0840	transmembrane signaling receptor activity
D9842_RS23800	COG0589	response to stress
D9842_RS23815	COG0393	Putative heavy-metal-binding
D9842_RS23820	COG0702	epimerase
D9842_RS23835	COG3842	ATPase activity
D9842_RS23840	COG2508	Transcriptional regulator
D9842_RS23860	COG0189	ligase activity
D9842_RS23865	COG0189	ligase activity
D9842_RS23875	COG4399	Belongs to the UPF0754 family
D9842_RS23880	COG3679	Belongs to the UPF0342 family
D9842_RS23885	COG0561	phosphatase activity
D9842_RS23895	COG4589	Belongs to the CDS family
D9842_RS23910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9842_RS23915	COG1024	Enoyl-CoA hydratase
D9842_RS23925	COG0420	3'-5' exonuclease activity
D9842_RS23930	COG4717	serine-type aminopeptidase activity
D9842_RS23935	COG3481	metal-dependent phosphohydrolase, HD sub domain
D9842_RS23945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9842_RS23990	COG1846	Transcriptional regulator
D9842_RS24010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9842_RS24020	COG0537	adenosine 5'-monophosphoramidase activity
D9842_RS24025	COG1131	(ABC) transporter
D9842_RS24030	COG4473	ABC transporter
D9842_RS24040	COG1473	amidohydrolase
D9842_RS24045	COG0671	phosphoesterase, PA-phosphatase related
D9842_RS24055	COG0667	Aldo Keto reductase
D9842_RS24060	COG3069	C4-dicarboxylate transmembrane transporter activity
D9842_RS24065	COG2329	Antibiotic biosynthesis monooxygenase
D9842_RS24070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9842_RS24075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9842_RS24080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9842_RS24085	COG0154	amidase activity
D9842_RS24095	COG1309	transcriptional regulator
D9842_RS24100	COG1511	domain protein
D9842_RS24105	COG0004	ammonium transporteR
D9842_RS24110	COG1609	Transcriptional regulator
D9842_RS24120	COG1234	tRNA 3'-trailer cleavage
D9842_RS24125	COG0318	PFAM AMP-dependent synthetase and ligase
D9842_RS24135	COG4120	Belongs to the binding-protein-dependent transport system permease family
D9842_RS24140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9842_RS24140	COG1116	anion transmembrane transporter activity
D9842_RS24150	COG0363	glucosamine-6-phosphate deaminase activity
D9842_RS24155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9842_RS24160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9842_RS24160	COG1263	PTS System
D9842_RS24165	COG2188	Transcriptional regulator
D9842_RS24175	COG4821	SIS domain
D9842_RS24180	COG1396	sequence-specific DNA binding
D9842_RS24185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D9842_RS24195	COG0501	Belongs to the peptidase M48B family
D9842_RS24200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9842_RS24205	COG2224	Isocitrate lyase
D9842_RS24215	COG4903	ComK protein
D9842_RS24230	COG0398	Pfam SNARE associated Golgi protein
D9842_RS24235	COG0681	Belongs to the peptidase S26 family
D9842_RS24245	COG0183	Belongs to the thiolase family
D9842_RS24255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D9842_RS24260	COG1074	ATP-dependent DNA helicase activity
D9842_RS24265	COG0420	3'-5' exonuclease activity
D9842_RS24270	COG0419	ATPase involved in DNA repair
D9842_RS24275	COG1403	HNH endonuclease
D9842_RS24320	COG0084	hydrolase, TatD family'
D9842_RS24325	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9842_RS24340	COG0367	asparagine synthase
D9842_RS24350	COG0534	Mate efflux family protein
D9842_RS24355	COG2207	Transcriptional regulator
D9842_RS24355	COG1917	Cupin 2, conserved barrel domain protein
D9842_RS24375	COG1028	Short-chain dehydrogenase reductase Sdr
D9842_RS24395	COG1410	methionine synthase
D9842_RS24395	COG0646	methionine synthase
D9842_RS24400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9842_RS24400	COG0646	methionine synthase
D9842_RS24405	COG1666	GTP binding
D9842_RS24410	COG2996	Protein conserved in bacteria
D9842_RS24415	COG1744	ABC transporter substrate-binding protein PnrA-like
D9842_RS24420	COG0840	transmembrane signaling receptor activity
D9842_RS24430	COG1307	EDD domain protein, DegV family
D9842_RS24435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9842_RS24450	COG0561	phosphatase activity
D9842_RS24455	COG1073	alpha beta
D9842_RS24460	COG2151	metal-sulfur cluster biosynthetic enzyme
D9842_RS24465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9842_RS24470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9842_RS24485	COG0505	Belongs to the CarA family
D9842_RS24490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9842_RS24495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9842_RS24525	COG2267	carboxylic ester hydrolase activity
D9842_RS24535	COG1744	ABC transporter substrate-binding protein PnrA-like
D9842_RS24550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9842_RS24555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9842_RS24560	COG5504	Zn-dependent protease
D9842_RS24570	COG0180	Tryptophanyl-tRNA synthetase
D9842_RS24580	COG4166	transmembrane transport
D9842_RS24585	COG0601	transmembrane transport
D9842_RS24590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9842_RS24595	COG0444	Belongs to the ABC transporter superfamily
D9842_RS24600	COG4608	Belongs to the ABC transporter superfamily
D9842_RS24605	COG0456	acetyltransferase
D9842_RS24610	COG1393	Belongs to the ArsC family
D9842_RS24615	COG0861	Integral membrane protein TerC family
D9842_RS24620	COG4862	establishment of competence for transformation
D9842_RS24625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9842_RS24640	COG1164	Oligoendopeptidase f
D9842_RS24650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9842_RS24655	COG2346	COG2346, Truncated hemoglobins
D9842_RS24660	COG0741	lytic transglycosylase activity
D9842_RS24665	COG4116	CYTH
D9842_RS24675	COG2357	RelA SpoT domain protein
D9842_RS24680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9842_RS24685	COG0564	pseudouridine synthase activity
D9842_RS24695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9842_RS24700	COG0772	Belongs to the SEDS family
D9842_RS24705	COG2239	Acts as a magnesium transporter
D9842_RS24710	COG0569	domain protein
D9842_RS24710	COG0475	glutathione-regulated potassium exporter activity
D9842_RS24715	COG0352	thiamine-phosphate diphosphorylase activity
D9842_RS24720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9842_RS24725	COG2104	thiamine diphosphate biosynthetic process
D9842_RS24730	COG2022	thiamine diphosphate biosynthetic process
D9842_RS24735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9842_RS24740	COG0351	phosphomethylpyrimidine kinase
D9842_RS24745	COG0352	thiamine-phosphate diphosphorylase activity
D9842_RS24750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9842_RS24755	COG5001	Diguanylate cyclase
D9842_RS24755	COG4251	negative regulation of phosphorylation
D9842_RS24755	COG3706	GGDEF domain
D9842_RS24755	COG2203	Gaf domain
D9842_RS24800	COG2323	membrane
D9842_RS24820	COG0210	DNA helicase
D9842_RS24835	COG2323	membrane
D9842_RS24845	COG2153	protein acetylation
D9842_RS24855	COG2382	esterase
D9842_RS24880	COG1999	signal sequence binding
D9842_RS24885	COG0626	cystathionine gamma-synthase activity
D9842_RS24890	COG0626	cystathionine gamma-synthase activity
D9842_RS24900	COG5577	PFAM Coat F domain
D9842_RS24910	COG1063	alcohol dehydrogenase
D9842_RS24915	COG5577	PFAM Coat F domain
D9842_RS24925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9842_RS24930	COG2358	TRAP transporter, solute receptor (TAXI family
D9842_RS24950	COG0582	viral genome integration into host DNA
D9842_RS24990	COG2207	Transcriptional regulator
D9842_RS24990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9842_RS24995	COG3275	phosphorelay sensor kinase activity
D9842_RS25005	COG1609	Transcriptional regulator
D9842_RS25015	COG1129	ABC transporter
D9842_RS25020	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9842_RS25025	COG0673	inositol 2-dehydrogenase activity
D9842_RS25030	COG1082	Xylose isomerase domain protein TIM barrel
D9842_RS25035	COG1063	alcohol dehydrogenase
D9842_RS25050	COG1879	ABC-type sugar transport system periplasmic component
D9842_RS25055	COG0673	inositol 2-dehydrogenase activity
D9842_RS25060	COG1959	2 iron, 2 sulfur cluster binding
D9842_RS25070	COG2972	Histidine kinase
D9842_RS25075	COG3279	Response regulator of the LytR AlgR family
D9842_RS25085	COG4209	transmembrane transport
D9842_RS25090	COG0395	ABC-type sugar transport system, permease component
D9842_RS25100	COG0789	Transcriptional regulator
D9842_RS25100	COG4978	Transcriptional regulator
D9842_RS25105	COG2814	Major facilitator Superfamily
D9842_RS25115	COG2259	Doxx family
D9842_RS25120	COG2514	catechol 2,3-dioxygenase activity
D9842_RS25125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9842_RS25130	COG0697	spore germination
D9842_RS25140	COG2208	phosphoserine phosphatase activity
D9842_RS25145	COG0596	Alpha beta hydrolase
D9842_RS25160	COG2814	Major facilitator Superfamily
D9842_RS25175	COG2814	Major facilitator Superfamily
D9842_RS25185	COG0254	rRNA binding
D9842_RS25205	COG0701	Predicted permease
D9842_RS25215	COG0822	iron-sulfur transferase activity
D9842_RS25225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9842_RS25230	COG0861	Integral membrane protein TerC family
D9842_RS25235	COG0789	Transcriptional regulator
D9842_RS25240	COG1253	flavin adenine dinucleotide binding
D9842_RS25255	COG2357	RelA SpoT domain protein
D9842_RS25270	COG0477	Major facilitator Superfamily
D9842_RS25275	COG0583	DNA-binding transcription factor activity
D9842_RS25305	COG0531	amino acid
D9842_RS25315	COG1846	Transcriptional regulator
D9842_RS25320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9842_RS25330	COG0657	acetylesterase activity
D9842_RS25330	COG2755	lipolytic protein G-D-S-L family
D9842_RS25335	COG0673	inositol 2-dehydrogenase activity
D9842_RS25345	COG0395	ABC-type sugar transport system, permease component
D9842_RS25355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9842_RS25360	COG2972	Histidine kinase
D9842_RS25365	COG4753	response regulator
D9842_RS25365	COG2207	Transcriptional regulator
D9842_RS25380	COG3866	Pectate lyase
D9842_RS25395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9842_RS25400	COG0772	Belongs to the SEDS family
D9842_RS25405	COG0772	Belongs to the SEDS family
D9842_RS25410	COG3339	Conserved Protein
D9842_RS25430	COG1510	regulation of RNA biosynthetic process
D9842_RS25435	COG0517	IMP dehydrogenase activity
D9842_RS25435	COG4175	Glycine betaine
D9842_RS25440	COG4176	ABC-type proline glycine betaine transport system permease component
D9842_RS25445	COG2113	Glycine betaine
D9842_RS25450	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9842_RS25475	COG1368	sulfuric ester hydrolase activity
D9842_RS25480	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9842_RS25490	COG2304	oxidoreductase activity
D9842_RS25495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS25495	COG3711	transcriptional antiterminator
D9842_RS25500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9842_RS25500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9842_RS25500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9842_RS25505	COG1482	cell wall glycoprotein biosynthetic process
D9842_RS25510	COG0300	oxidoreductase activity
D9842_RS25515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9842_RS25520	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D9842_RS25525	COG1733	regulation of RNA biosynthetic process
D9842_RS25535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9842_RS25540	COG2207	Transcriptional regulator
D9842_RS25540	COG4753	response regulator
D9842_RS25545	COG2972	Histidine kinase
D9842_RS25565	COG3250	beta-galactosidase activity