locus-tag	class	description
D5E69_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5E69_RS00010	COG0592	DNA-directed DNA polymerase activity
D5E69_RS00015	COG2501	S4 domain
D5E69_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5E69_RS00030	COG0187	DNA topoisomerase II activity
D5E69_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5E69_RS00070	COG0386	Belongs to the glutathione peroxidase family
D5E69_RS00080	COG0516	GMP reductase activity
D5E69_RS00080	COG0517	IMP dehydrogenase activity
D5E69_RS00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D5E69_RS00125	COG1428	Deoxynucleoside kinase
D5E69_RS00130	COG1428	Deoxynucleoside kinase
D5E69_RS00140	COG1335	isochorismatase
D5E69_RS00145	COG0590	tRNA wobble adenosine to inosine editing
D5E69_RS00160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5E69_RS00165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5E69_RS00220	COG1982	Orn Lys Arg decarboxylase major
D5E69_RS00225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5E69_RS00230	COG3870	Protein conserved in bacteria
D5E69_RS00235	COG1728	Protein conserved in bacteria
D5E69_RS00240	COG0470	DNA polymerase III
D5E69_RS00245	COG1774	PSP1 C-terminal conserved region
D5E69_RS00250	COG4467	Involved in initiation control of chromosome replication
D5E69_RS00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5E69_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5E69_RS00265	COG2002	toxin-antitoxin pair type II binding
D5E69_RS00275	COG0084	hydrolase, TatD family'
D5E69_RS00300	COG4466	Protein conserved in bacteria
D5E69_RS00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5E69_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_RS00320	COG0251	oxidation-reduction process
D5E69_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5E69_RS00345	COG0193	aminoacyl-tRNA hydrolase activity
D5E69_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5E69_RS00360	COG2002	toxin-antitoxin pair type II binding
D5E69_RS00365	COG2244	polysaccharide biosynthetic process
D5E69_RS00370	COG3956	TIGRFAM MazG family protein
D5E69_RS00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5E69_RS00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5E69_RS00395	COG1098	S1 RNA binding domain
D5E69_RS00410	COG2208	phosphoserine phosphatase activity
D5E69_RS00415	COG2304	oxidoreductase activity
D5E69_RS00420	COG0515	serine threonine protein kinase
D5E69_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5E69_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D5E69_RS00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_RS00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5E69_RS00465	COG0512	Glutamine amidotransferase of anthranilate synthase
D5E69_RS00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5E69_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5E69_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5E69_RS00490	COG1396	sequence-specific DNA binding
D5E69_RS00580	COG3880	PFAM UvrB UvrC protein
D5E69_RS00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D5E69_RS00590	COG0542	response to heat
D5E69_RS00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D5E69_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
D5E69_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5E69_RS00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5E69_RS00625	COG1045	serine acetyltransferase
D5E69_RS00630	COG0215	cysteine-tRNA ligase activity
D5E69_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5E69_RS00645	COG3688	RNA-binding protein containing a PIN domain
D5E69_RS00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5E69_RS00665	COG0250	Participates in transcription elongation, termination and antitermination
D5E69_RS00675	COG0081	regulation of translation
D5E69_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5E69_RS00690	COG2813	Specifically methylates the guanine in position
D5E69_RS00705	COG1358	cellular component organization or biogenesis
D5E69_RS00715	COG0049	tRNA binding
D5E69_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5E69_RS00730	COG0051	transcription antitermination factor activity, RNA binding
D5E69_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5E69_RS00740	COG0088	Forms part of the polypeptide exit tunnel
D5E69_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5E69_RS00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5E69_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5E69_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5E69_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
D5E69_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5E69_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5E69_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5E69_RS00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5E69_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5E69_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5E69_RS00825	COG1841	ribosomal large subunit assembly
D5E69_RS00835	COG0201	protein transport
D5E69_RS00840	COG0563	adenylate kinase activity
D5E69_RS00845	COG0024	Methionine aminopeptidase
D5E69_RS00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D5E69_RS00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5E69_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5E69_RS00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5E69_RS00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5E69_RS00875	COG0202	RNA polymerase activity
D5E69_RS00880	COG0203	ribosomal protein L17
D5E69_RS00885	COG1122	ATPase activity
D5E69_RS00890	COG1122	ATPase activity
D5E69_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D5E69_RS00900	COG0101	tRNA pseudouridine synthase activity
D5E69_RS00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5E69_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5E69_RS00920	COG4282	regulation of fungal-type cell wall biogenesis
D5E69_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS00935	COG0489	protein tyrosine kinase activity
D5E69_RS00945	COG2194	sulfuric ester hydrolase activity
D5E69_RS00950	COG0726	polysaccharide deacetylase
D5E69_RS01025	COG1595	DNA-templated transcription, initiation
D5E69_RS01030	COG5662	AntiSigma factor
D5E69_RS01035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D5E69_RS01040	COG4856	YbbR-like protein
D5E69_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5E69_RS01050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5E69_RS01060	COG2226	methyltransferase
D5E69_RS01070	COG0346	lactoylglutathione lyase activity
D5E69_RS01090	COG0726	polysaccharide deacetylase
D5E69_RS01100	COG0745	RESPONSE REGULATOR receiver
D5E69_RS01105	COG5002	protein histidine kinase activity
D5E69_RS01120	COG0346	lactoylglutathione lyase activity
D5E69_RS01125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_RS01135	COG1733	regulation of RNA biosynthetic process
D5E69_RS01140	COG2814	Major facilitator Superfamily
D5E69_RS01165	COG1510	regulation of RNA biosynthetic process
D5E69_RS01170	COG0517	IMP dehydrogenase activity
D5E69_RS01170	COG4175	Glycine betaine
D5E69_RS01175	COG4176	ABC-type proline glycine betaine transport system permease component
D5E69_RS01180	COG2113	Glycine betaine
D5E69_RS01185	COG0454	-acetyltransferase
D5E69_RS01195	COG0840	transmembrane signaling receptor activity
D5E69_RS01205	COG0577	efflux transmembrane transporter activity
D5E69_RS01210	COG1136	(ABC) transporter
D5E69_RS01210	COG0577	efflux transmembrane transporter activity
D5E69_RS01220	COG5002	protein histidine kinase activity
D5E69_RS01235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_RS01240	COG1116	anion transmembrane transporter activity
D5E69_RS01245	COG1940	carbohydrate kinase activity
D5E69_RS01250	COG0800	Aldolase
D5E69_RS01260	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D5E69_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS01275	COG1414	Transcriptional regulator
D5E69_RS01290	COG1175	transmembrane transport
D5E69_RS01295	COG0395	ABC-type sugar transport system, permease component
D5E69_RS01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_RS01305	COG1609	Transcriptional regulator
D5E69_RS01310	COG0673	inositol 2-dehydrogenase activity
D5E69_RS01325	COG3962	Belongs to the TPP enzyme family
D5E69_RS01330	COG1082	Xylose isomerase domain protein TIM barrel
D5E69_RS01390	COG0601	transmembrane transport
D5E69_RS01395	COG2861	carbohydrate metabolic process
D5E69_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS01405	COG1757	Na H antiporter
D5E69_RS01425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_RS01430	COG4585	Histidine kinase
D5E69_RS01435	COG2197	response regulator
D5E69_RS01440	COG1131	(ABC) transporter
D5E69_RS01470	COG1597	lipid kinase activity
D5E69_RS01475	COG1238	metal cluster binding
D5E69_RS01480	COG0018	arginyl-trna synthetase
D5E69_RS01485	COG0772	Belongs to the SEDS family
D5E69_RS01490	COG1253	flavin adenine dinucleotide binding
D5E69_RS01500	COG1489	DNA binding
D5E69_RS01510	COG4134	Bacterial extracellular solute-binding protein
D5E69_RS01525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D5E69_RS01530	COG0398	Pfam SNARE associated Golgi protein
D5E69_RS01560	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5E69_RS01565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5E69_RS01575	COG0513	Belongs to the DEAD box helicase family
D5E69_RS01580	COG4294	response to UV
D5E69_RS01585	COG3402	PFAM membrane-flanked domain
D5E69_RS01590	COG3428	Bacterial PH domain
D5E69_RS01595	COG0705	Rhomboid family
D5E69_RS01600	COG0736	holo-[acyl-carrier-protein] synthase activity
D5E69_RS01620	COG2337	Toxic component of a toxin-antitoxin (TA) module
D5E69_RS01655	COG1191	sigma factor activity
D5E69_RS01660	COG2208	phosphoserine phosphatase activity
D5E69_RS01665	COG2183	response to ionizing radiation
D5E69_RS01675	COG3091	SprT-like family
D5E69_RS01760	COG0802	atpase or kinase
D5E69_RS01765	COG1214	PFAM Peptidase M22, glycoprotease
D5E69_RS01770	COG0456	acetyltransferase
D5E69_RS01780	COG0488	(ABC) transporter
D5E69_RS01785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D5E69_RS01790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5E69_RS01795	COG0805	protein transport
D5E69_RS01805	COG1266	CAAX protease self-immunity
D5E69_RS01810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5E69_RS01815	COG0459	protein refolding
D5E69_RS01820	COG1940	carbohydrate kinase activity
D5E69_RS01835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS01840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS01840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS01840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS01850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_RS01855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5E69_RS01870	COG4174	ABC transporter (Permease)
D5E69_RS01880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5E69_RS01885	COG3773	Cell wall hydrolase
D5E69_RS01890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS01895	COG0673	inositol 2-dehydrogenase activity
D5E69_RS01905	COG0673	inositol 2-dehydrogenase activity
D5E69_RS01910	COG2226	methyltransferase
D5E69_RS01915	COG3300	MHYT domain
D5E69_RS01915	COG5001	Diguanylate cyclase
D5E69_RS01930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5E69_RS01940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5E69_RS01945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5E69_RS01955	COG0714	Associated with various cellular activities
D5E69_RS01960	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D5E69_RS01970	COG1305	Transglutaminase-like
D5E69_RS01980	COG2252	PERMEase
D5E69_RS01985	COG3711	transcriptional antiterminator
D5E69_RS02010	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D5E69_RS02020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D5E69_RS02025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5E69_RS02030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5E69_RS02040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5E69_RS02045	COG0047	phosphoribosylformylglycinamidine synthase activity
D5E69_RS02050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5E69_RS02055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5E69_RS02065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5E69_RS02075	COG0151	Belongs to the GarS family
D5E69_RS02090	COG1470	cell adhesion involved in biofilm formation
D5E69_RS02095	COG4496	protein, YerC YecD
D5E69_RS02100	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D5E69_RS02105	COG0210	DNA helicase
D5E69_RS02115	COG4851	CamS sex pheromone cAM373 precursor
D5E69_RS02120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5E69_RS02125	COG2224	Isocitrate lyase
D5E69_RS02130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5E69_RS02135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5E69_RS02140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5E69_RS02150	COG0505	Belongs to the CarA family
D5E69_RS02155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5E69_RS02160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5E69_RS02165	COG5506	Protein of unknown function (DUF1694)
D5E69_RS02180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5E69_RS02185	COG0154	amidase activity
D5E69_RS02220	COG1597	lipid kinase activity
D5E69_RS02245	COG0166	Belongs to the GPI family
D5E69_RS02250	COG4895	conserved protein (DUF2196)
D5E69_RS02255	COG1984	allophanate hydrolase subunit 2
D5E69_RS02260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D5E69_RS02265	COG2814	Major facilitator Superfamily
D5E69_RS02280	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_RS02285	COG1131	(ABC) transporter
D5E69_RS02315	COG2966	Psort location CytoplasmicMembrane, score
D5E69_RS02320	COG3610	response to peptide
D5E69_RS02335	COG1132	(ABC) transporter
D5E69_RS02340	COG3871	stress protein (general stress protein 26)
D5E69_RS02380	COG2364	Membrane
D5E69_RS02385	COG1199	ATP-dependent helicase activity
D5E69_RS02390	COG2193	ferroxidase activity
D5E69_RS02405	COG1404	Belongs to the peptidase S8 family
D5E69_RS02410	COG2032	superoxide dismutase activity
D5E69_RS02415	COG0733	neurotransmitter:sodium symporter activity
D5E69_RS02420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_RS02425	COG0488	(ABC) transporter
D5E69_RS02430	COG1609	Transcriptional regulator
D5E69_RS02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_RS02440	COG1869	D-ribose catabolic process
D5E69_RS02445	COG1129	ABC transporter
D5E69_RS02450	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5E69_RS02455	COG1879	ABC-type sugar transport system periplasmic component
D5E69_RS02465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS02470	COG1846	Transcriptional regulator
D5E69_RS02475	COG0477	Major facilitator Superfamily
D5E69_RS02485	COG3396	Phenylacetate-CoA oxygenase
D5E69_RS02500	COG2151	metal-sulfur cluster biosynthetic enzyme
D5E69_RS02515	COG1024	Enoyl-CoA hydratase
D5E69_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS02525	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_RS02530	COG0183	Belongs to the thiolase family
D5E69_RS02540	COG3327	negative regulation of DNA-templated transcription, initiation
D5E69_RS02565	COG4120	Belongs to the binding-protein-dependent transport system permease family
D5E69_RS02570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_RS02610	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D5E69_RS02615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5E69_RS02635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_RS02640	COG0129	dihydroxy-acid dehydratase activity
D5E69_RS02645	COG0028	Belongs to the TPP enzyme family
D5E69_RS02650	COG0440	acetolactate synthase activity
D5E69_RS02655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5E69_RS02660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_RS02670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5E69_RS02675	COG0066	3-isopropylmalate dehydratase activity
D5E69_RS02685	COG0460	homoserine dehydrogenase
D5E69_RS02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5E69_RS02695	COG0083	homoserine kinase activity
D5E69_RS02705	COG3852	Histidine kinase
D5E69_RS02720	COG4106	trans-aconitate 2-methyltransferase activity
D5E69_RS02750	COG1957	nucleoside hydrolase
D5E69_RS02755	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5E69_RS02765	COG3842	ATPase activity
D5E69_RS02770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5E69_RS02775	COG1737	Transcriptional regulator
D5E69_RS02780	COG1070	Carbohydrate kinase
D5E69_RS02790	COG0702	epimerase
D5E69_RS02795	COG1309	transcriptional regulator
D5E69_RS02800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5E69_RS02805	COG2244	polysaccharide biosynthetic process
D5E69_RS02850	COG2197	response regulator
D5E69_RS02870	COG0714	Associated with various cellular activities
D5E69_RS02885	COG1714	RDD family
D5E69_RS02900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS02900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS02900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS02905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS02910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS02915	COG0383	alpha-mannosidase activity
D5E69_RS02920	COG3711	transcriptional antiterminator
D5E69_RS02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS02925	COG0456	acetyltransferase
D5E69_RS02935	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS02945	COG2130	NADP-dependent
D5E69_RS02965	COG0288	reversible hydration of carbon dioxide
D5E69_RS02990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS03000	COG0488	(ABC) transporter
D5E69_RS03015	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D5E69_RS03030	COG1595	DNA-templated transcription, initiation
D5E69_RS03035	COG1077	Cell shape determining protein MreB Mrl
D5E69_RS03040	COG0840	transmembrane signaling receptor activity
D5E69_RS03050	COG1607	acyl-coa hydrolase
D5E69_RS03070	COG2267	carboxylic ester hydrolase activity
D5E69_RS03080	COG2309	aminopeptidase activity
D5E69_RS03085	COG1959	2 iron, 2 sulfur cluster binding
D5E69_RS03105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5E69_RS03110	COG1360	Flagellar Motor Protein
D5E69_RS03125	COG1115	amino acid carrier protein
D5E69_RS03130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS03135	COG4605	iron ion homeostasis
D5E69_RS03140	COG4604	ABC transporter, ATP-binding protein
D5E69_RS03145	COG4607	ABC-type enterochelin transport system periplasmic component
D5E69_RS03150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_RS03155	COG2313	pseudouridylate synthase activity
D5E69_RS03160	COG5002	protein histidine kinase activity
D5E69_RS03175	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D5E69_RS03180	COG0693	protein deglycase activity
D5E69_RS03195	COG1295	ribonuclease BN
D5E69_RS03200	COG1966	Carbon starvation protein
D5E69_RS03215	COG5578	integral membrane protein
D5E69_RS03220	COG1653	transport
D5E69_RS03230	COG0395	ABC-type sugar transport system, permease component
D5E69_RS03255	COG1063	alcohol dehydrogenase
D5E69_RS03260	COG0673	inositol 2-dehydrogenase activity
D5E69_RS03265	COG0673	inositol 2-dehydrogenase activity
D5E69_RS03295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_RS03305	COG1309	transcriptional regulator
D5E69_RS03320	COG1126	abc transporter atp-binding protein
D5E69_RS03345	COG2190	(PTS) system
D5E69_RS03345	COG1263	PTS System
D5E69_RS03345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS03360	COG4208	sulfate ABC transporter
D5E69_RS03370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5E69_RS03380	COG2217	Heavy metal translocating P-type atpase
D5E69_RS03385	COG0477	Major facilitator Superfamily
D5E69_RS03450	COG1131	(ABC) transporter
D5E69_RS03460	COG0387	Pfam Sodium calcium exchanger
D5E69_RS03480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS03485	COG0535	radical SAM domain protein
D5E69_RS03505	COG2323	membrane
D5E69_RS03535	COG2226	methyltransferase
D5E69_RS03540	COG2210	Belongs to the sulfur carrier protein TusA family
D5E69_RS03550	COG0425	Belongs to the sulfur carrier protein TusA family
D5E69_RS03550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_RS03555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_RS03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS03560	COG0425	Belongs to the sulfur carrier protein TusA family
D5E69_RS03580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5E69_RS03605	COG1131	(ABC) transporter
D5E69_RS03620	COG0561	phosphatase activity
D5E69_RS03635	COG0531	amino acid
D5E69_RS03645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS03650	COG1575	Belongs to the MenA family. Type 1 subfamily
D5E69_RS03670	COG1335	isochorismatase
D5E69_RS03675	COG1522	sequence-specific DNA binding
D5E69_RS03700	COG1979	alcohol dehydrogenase
D5E69_RS03705	COG1683	Conserved Protein
D5E69_RS03715	COG1473	amidohydrolase
D5E69_RS03745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS03770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5E69_RS03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5E69_RS03800	COG0494	nUDIX hydrolase
D5E69_RS03815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_RS03820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_RS03835	COG0588	phosphoglycerate mutase activity
D5E69_RS03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_RS03870	COG0456	acetyltransferase
D5E69_RS03930	COG1175	transmembrane transport
D5E69_RS03935	COG0395	ABC-type sugar transport system, permease component
D5E69_RS03955	COG2910	NAD(P)H-binding
D5E69_RS03960	COG1959	2 iron, 2 sulfur cluster binding
D5E69_RS03965	COG2814	Major facilitator Superfamily
D5E69_RS03970	COG0640	Transcriptional regulator
D5E69_RS03980	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_RS03985	COG1178	ABC-type Fe3 transport system permease component
D5E69_RS03990	COG3842	ATPase activity
D5E69_RS03995	COG0456	acetyltransferase
D5E69_RS04005	COG2808	Putative FMN-binding domain
D5E69_RS04010	COG1388	LysM domain
D5E69_RS04020	COG1595	DNA-templated transcription, initiation
D5E69_RS04035	COG1454	alcohol dehydrogenase
D5E69_RS04055	COG0456	acetyltransferase
D5E69_RS04080	COG1609	Transcriptional regulator
D5E69_RS04085	COG0561	phosphatase activity
D5E69_RS04100	COG0210	DNA helicase
D5E69_RS04145	COG2318	DinB family
D5E69_RS04155	COG1846	Transcriptional regulator
D5E69_RS04165	COG0789	Transcriptional regulator
D5E69_RS04170	COG1064	alcohol dehydrogenase
D5E69_RS04190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5E69_RS04195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5E69_RS04215	COG0406	alpha-ribazole phosphatase activity
D5E69_RS04220	COG0110	maltose O-acetyltransferase activity
D5E69_RS04225	COG3420	alginic acid biosynthetic process
D5E69_RS04240	COG1280	lysine exporter protein (LysE YggA)
D5E69_RS04250	COG1136	(ABC) transporter
D5E69_RS04290	COG0583	DNA-binding transcription factor activity
D5E69_RS04295	COG0778	Nitroreductase
D5E69_RS04325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS04345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5E69_RS04350	COG1595	DNA-templated transcription, initiation
D5E69_RS04360	COG2318	DinB family
D5E69_RS04375	COG2169	Transcriptional regulator
D5E69_RS04380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5E69_RS04385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5E69_RS04405	COG2207	Transcriptional regulator
D5E69_RS04405	COG3708	Transcriptional regulator
D5E69_RS04415	COG0583	DNA-binding transcription factor activity
D5E69_RS04420	COG2267	carboxylic ester hydrolase activity
D5E69_RS04440	COG2267	carboxylic ester hydrolase activity
D5E69_RS04460	COG1733	regulation of RNA biosynthetic process
D5E69_RS04470	COG2367	Beta-lactamase
D5E69_RS04500	COG2076	Multidrug Resistance protein
D5E69_RS04505	COG2076	Multidrug Resistance protein
D5E69_RS04510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5E69_RS04515	COG5002	protein histidine kinase activity
D5E69_RS04520	COG0745	RESPONSE REGULATOR receiver
D5E69_RS04530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5E69_RS04535	COG1696	Membrane protein involved in D-alanine export
D5E69_RS04540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5E69_RS04545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D5E69_RS04565	COG1253	flavin adenine dinucleotide binding
D5E69_RS04570	COG1253	flavin adenine dinucleotide binding
D5E69_RS04615	COG1595	DNA-templated transcription, initiation
D5E69_RS04635	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_RS04640	COG3842	ATPase activity
D5E69_RS04665	COG2376	Dihydroxyacetone kinase
D5E69_RS04680	COG5444	nuclease activity
D5E69_RS04710	COG2801	Transposase and inactivated derivatives
D5E69_RS04725	COG0300	oxidoreductase activity
D5E69_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS04755	COG1104	cysteine desulfurase activity
D5E69_RS04810	COG5505	Protein of unknown function (DUF819)
D5E69_RS04885	COG1316	TRANSCRIPTIONal
D5E69_RS04895	COG5002	protein histidine kinase activity
D5E69_RS04900	COG0745	RESPONSE REGULATOR receiver
D5E69_RS04950	COG0305	Participates in initiation and elongation during chromosome replication
D5E69_RS04980	COG3655	Transcriptional regulator
D5E69_RS05005	COG0789	Transcriptional regulator
D5E69_RS05030	COG1131	(ABC) transporter
D5E69_RS05055	COG0165	Argininosuccinate lyase
D5E69_RS05065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_RS05075	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS05080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5E69_RS05085	COG2197	response regulator
D5E69_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS05100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5E69_RS05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS05120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS05180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5E69_RS05215	COG5002	protein histidine kinase activity
D5E69_RS05220	COG0456	acetyltransferase
D5E69_RS05220	COG0454	-acetyltransferase
D5E69_RS05225	COG1378	Sugar-specific transcriptional regulator TrmB
D5E69_RS05230	COG1280	lysine exporter protein (LysE YggA)
D5E69_RS05285	COG1464	Belongs to the NlpA lipoprotein family
D5E69_RS05290	COG2011	ABC-type metal ion transport system permease component
D5E69_RS05295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_RS05300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS05350	COG1063	alcohol dehydrogenase
D5E69_RS05360	COG1695	Transcriptional regulator
D5E69_RS05390	COG1396	sequence-specific DNA binding
D5E69_RS05405	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS05410	COG0840	transmembrane signaling receptor activity
D5E69_RS05420	COG4213	ABC transporter substrate-binding protein
D5E69_RS05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5E69_RS05440	COG2972	Histidine kinase
D5E69_RS05445	COG2207	Transcriptional regulator
D5E69_RS05445	COG4753	response regulator
D5E69_RS05450	COG4213	ABC transporter substrate-binding protein
D5E69_RS05470	COG4224	UPF0291 protein
D5E69_RS05475	COG0577	efflux transmembrane transporter activity
D5E69_RS05490	COG0840	transmembrane signaling receptor activity
D5E69_RS05495	COG2226	methyltransferase
D5E69_RS05545	COG1070	Carbohydrate kinase
D5E69_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_RS05555	COG2207	Transcriptional regulator
D5E69_RS05560	COG0395	ABC-type sugar transport system, permease component
D5E69_RS05565	COG4209	transmembrane transport
D5E69_RS05570	COG5578	integral membrane protein
D5E69_RS05575	COG1653	transport
D5E69_RS05580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_RS05590	COG1073	alpha beta
D5E69_RS05620	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D5E69_RS05635	COG1279	arginine transmembrane transporter activity
D5E69_RS05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_RS05650	COG5002	protein histidine kinase activity
D5E69_RS05650	COG3850	Histidine kinase
D5E69_RS05670	COG0346	lactoylglutathione lyase activity
D5E69_RS05680	COG1131	(ABC) transporter
D5E69_RS05735	COG0592	DNA-directed DNA polymerase activity
D5E69_RS05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_RS05760	COG0596	Alpha beta hydrolase
D5E69_RS05785	COG1408	metallophosphoesterase
D5E69_RS05830	COG1051	belongs to the nudix hydrolase family
D5E69_RS05855	COG0656	L-ascorbic acid biosynthetic process
D5E69_RS05875	COG0384	phenazine biosynthesis protein PhzF
D5E69_RS05880	COG0346	lactoylglutathione lyase activity
D5E69_RS05895	COG1794	racemase activity, acting on amino acids and derivatives
D5E69_RS05900	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS05915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_RS05930	COG1309	transcriptional regulator
D5E69_RS05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS05945	COG1609	Transcriptional regulator
D5E69_RS05950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_RS05955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_RS05965	COG1063	alcohol dehydrogenase
D5E69_RS05980	COG2213	PTS system mannitol-specific
D5E69_RS05980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS05985	COG3711	transcriptional antiterminator
D5E69_RS05990	COG0246	Mannitol dehydrogenase
D5E69_RS06010	COG0640	Transcriptional regulator
D5E69_RS06030	COG1136	(ABC) transporter
D5E69_RS06070	COG2217	Heavy metal translocating P-type atpase
D5E69_RS06075	COG2608	mercury ion transmembrane transporter activity
D5E69_RS06080	COG1937	Protein conserved in bacteria
D5E69_RS06090	COG1280	lysine exporter protein (LysE YggA)
D5E69_RS06095	COG1051	belongs to the nudix hydrolase family
D5E69_RS06100	COG1368	sulfuric ester hydrolase activity
D5E69_RS06110	COG0596	Alpha beta hydrolase
D5E69_RS06115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D5E69_RS06120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D5E69_RS06125	COG1733	regulation of RNA biosynthetic process
D5E69_RS06130	COG1253	flavin adenine dinucleotide binding
D5E69_RS06140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5E69_RS06160	COG5002	protein histidine kinase activity
D5E69_RS06175	COG1477	protein flavinylation
D5E69_RS06185	COG1132	(ABC) transporter
D5E69_RS06190	COG1132	(ABC) transporter
D5E69_RS06200	COG0662	Cupin 2, conserved barrel domain protein
D5E69_RS06205	COG2814	Major facilitator Superfamily
D5E69_RS06240	COG2828	Protein conserved in bacteria
D5E69_RS06245	COG0583	DNA-binding transcription factor activity
D5E69_RS06250	COG2851	Citrate transporter
D5E69_RS06260	COG0583	DNA-binding transcription factor activity
D5E69_RS06265	COG0730	response to heat
D5E69_RS06275	COG0586	Pfam SNARE associated Golgi protein
D5E69_RS06280	COG1846	Transcriptional regulator
D5E69_RS06285	COG2814	Major facilitator Superfamily
D5E69_RS06320	COG3290	protein histidine kinase activity
D5E69_RS06325	COG4565	transcriptional regulatory protein
D5E69_RS06360	COG2153	protein acetylation
D5E69_RS06365	COG0300	oxidoreductase activity
D5E69_RS06400	COG1131	(ABC) transporter
D5E69_RS06405	COG4152	abc transporter atp-binding protein
D5E69_RS06420	COG1164	Oligoendopeptidase f
D5E69_RS06425	COG2267	carboxylic ester hydrolase activity
D5E69_RS06440	COG1247	-acetyltransferase
D5E69_RS06450	COG2323	membrane
D5E69_RS06465	COG0412	Dienelactone hydrolase
D5E69_RS06510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5E69_RS06520	COG2267	carboxylic ester hydrolase activity
D5E69_RS06525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5E69_RS06530	COG0456	acetyltransferase
D5E69_RS06555	COG1131	(ABC) transporter
D5E69_RS06590	COG0501	Belongs to the peptidase M48B family
D5E69_RS06595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5E69_RS06600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D5E69_RS06605	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_RS06610	COG0582	viral genome integration into host DNA
D5E69_RS06625	COG2111	Na H antiporter
D5E69_RS06635	COG0651	ATP synthesis coupled electron transport
D5E69_RS06640	COG1863	multisubunit Na H antiporter MnhE subunit
D5E69_RS06645	COG2212	antiporter activity
D5E69_RS06650	COG1320	monovalent cation:proton antiporter activity
D5E69_RS06665	COG0833	amino acid
D5E69_RS06670	COG2040	homocysteine
D5E69_RS06675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_RS06685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_RS06695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS06705	COG1476	TRANSCRIPTIONal
D5E69_RS06715	COG3239	Fatty acid desaturase
D5E69_RS06720	COG2197	response regulator
D5E69_RS06725	COG1609	Transcriptional regulator
D5E69_RS06735	COG1621	beta-fructofuranosidase activity
D5E69_RS06740	COG0306	phosphate transporter
D5E69_RS06745	COG1392	Phosphate transport regulator
D5E69_RS06750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5E69_RS06760	COG5444	nuclease activity
D5E69_RS06800	COG0789	Transcriptional regulator
D5E69_RS06805	COG1278	Cold shock
D5E69_RS06815	COG2124	cytochrome p450
D5E69_RS06815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5E69_RS06820	COG1309	transcriptional regulator
D5E69_RS06825	COG3290	protein histidine kinase activity
D5E69_RS06830	COG3279	Response regulator of the LytR AlgR family
D5E69_RS06835	COG4555	ABC transporter
D5E69_RS06840	COG1668	transmembrane transport
D5E69_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS06865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5E69_RS06870	COG1115	amino acid carrier protein
D5E69_RS06875	COG2508	Transcriptional regulator
D5E69_RS06875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_RS06880	COG2508	Transcriptional regulator
D5E69_RS06880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_RS06885	COG0686	Belongs to the AlaDH PNT family
D5E69_RS06900	COG1725	Transcriptional regulator
D5E69_RS06905	COG0398	Pfam SNARE associated Golgi protein
D5E69_RS06930	COG0640	Transcriptional regulator
D5E69_RS06945	COG2205	protein histidine kinase activity
D5E69_RS06960	COG1131	(ABC) transporter
D5E69_RS06965	COG1114	Component of the transport system for branched-chain amino acids
D5E69_RS06975	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS06980	COG0604	alcohol dehydrogenase
D5E69_RS07000	COG2207	Transcriptional regulator
D5E69_RS07000	COG3708	Transcriptional regulator
D5E69_RS07035	COG0778	Nitroreductase
D5E69_RS07050	COG0247	lactate metabolic process
D5E69_RS07055	COG0277	FAD linked oxidase domain protein
D5E69_RS07065	COG2971	BadF BadG BcrA BcrD
D5E69_RS07075	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5E69_RS07080	COG1737	Transcriptional regulator
D5E69_RS07100	COG1486	melibiose metabolic process
D5E69_RS07105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5E69_RS07110	COG1649	PFAM Uncharacterised BCR, COG1649
D5E69_RS07120	COG0493	'glutamate synthase
D5E69_RS07125	COG1263	PTS System
D5E69_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS07135	COG1657	PFAM Prenyltransferase squalene oxidase
D5E69_RS07140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D5E69_RS07160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_RS07165	COG2268	Band 7 protein
D5E69_RS07170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5E69_RS07185	COG1073	alpha beta
D5E69_RS07190	COG0277	FAD linked oxidase domain protein
D5E69_RS07195	COG0385	Bile acid
D5E69_RS07205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS07210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS07215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS07220	COG1120	ATPase activity
D5E69_RS07230	COG0861	Integral membrane protein TerC family
D5E69_RS07250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5E69_RS07255	COG2270	Major facilitator Superfamily
D5E69_RS07270	COG0789	Transcriptional regulator
D5E69_RS07275	COG1725	Transcriptional regulator
D5E69_RS07280	COG1131	(ABC) transporter
D5E69_RS07315	COG2186	Transcriptional regulator
D5E69_RS07320	COG0277	FAD linked oxidase domain protein
D5E69_RS07325	COG0247	lactate metabolic process
D5E69_RS07330	COG0579	oxidoreductase
D5E69_RS07335	COG0542	response to heat
D5E69_RS07340	COG0561	phosphatase activity
D5E69_RS07345	COG1132	(ABC) transporter
D5E69_RS07350	COG3695	enzyme binding
D5E69_RS07365	COG1090	epimerase
D5E69_RS07375	COG0300	oxidoreductase activity
D5E69_RS07405	COG1194	a g-specific adenine glycosylase
D5E69_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS07430	COG3557	Belongs to the UPF0374 family
D5E69_RS07435	COG1132	(ABC) transporter
D5E69_RS07440	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS07445	COG4608	Belongs to the ABC transporter superfamily
D5E69_RS07450	COG0747	negative chemotaxis
D5E69_RS07465	COG4129	membrane
D5E69_RS07470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5E69_RS07480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5E69_RS07490	COG2096	Adenosyltransferase
D5E69_RS07495	COG0735	belongs to the Fur family
D5E69_RS07625	COG2972	Histidine kinase
D5E69_RS07640	COG0673	inositol 2-dehydrogenase activity
D5E69_RS07645	COG0673	inositol 2-dehydrogenase activity
D5E69_RS07650	COG1082	Xylose isomerase domain protein TIM barrel
D5E69_RS07655	COG3382	B3 4 domain protein
D5E69_RS07670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5E69_RS07675	COG0778	Nitroreductase
D5E69_RS07680	COG2766	serine protein kinase
D5E69_RS07700	COG2267	carboxylic ester hydrolase activity
D5E69_RS07705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_RS07710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5E69_RS07715	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5E69_RS07730	COG0039	L-malate dehydrogenase activity
D5E69_RS07745	COG2252	PERMEase
D5E69_RS07750	COG1522	sequence-specific DNA binding
D5E69_RS07760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5E69_RS07765	COG4978	Transcriptional regulator
D5E69_RS07765	COG0789	Transcriptional regulator
D5E69_RS07780	COG4988	ABC transporter
D5E69_RS07785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5E69_RS07790	COG0778	Nitroreductase
D5E69_RS07795	COG1609	Transcriptional regulator
D5E69_RS07810	COG2205	protein histidine kinase activity
D5E69_RS07815	COG5002	protein histidine kinase activity
D5E69_RS07820	COG0546	phosphoglycolate phosphatase activity
D5E69_RS07825	COG3973	AAA domain
D5E69_RS07830	COG0656	L-ascorbic acid biosynthetic process
D5E69_RS07835	COG0564	pseudouridine synthase activity
D5E69_RS07850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5E69_RS07855	COG3153	acetyltransferase
D5E69_RS07855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5E69_RS07860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5E69_RS07865	COG2203	Gaf domain
D5E69_RS07865	COG4585	Histidine kinase
D5E69_RS07870	COG2197	response regulator
D5E69_RS07875	COG0431	NADPH-dependent FMN reductase
D5E69_RS07895	COG2719	SpoVR family
D5E69_RS07910	COG4989	oxidoreductase activity
D5E69_RS07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5E69_RS07925	COG0011	TIGRFAM Protein of
D5E69_RS07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_RS07940	COG0084	hydrolase, TatD family'
D5E69_RS07950	COG1533	DNA photolyase activity
D5E69_RS07960	COG1301	dicarboxylic acid transport
D5E69_RS07970	COG0415	Belongs to the DNA photolyase family
D5E69_RS07975	COG0589	response to stress
D5E69_RS07980	COG1132	(ABC) transporter
D5E69_RS07990	COG0702	epimerase
D5E69_RS07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_RS08000	COG0765	amino acid transport
D5E69_RS08005	COG1126	abc transporter atp-binding protein
D5E69_RS08025	COG3842	ATPase activity
D5E69_RS08030	COG2508	Transcriptional regulator
D5E69_RS08035	COG1937	Protein conserved in bacteria
D5E69_RS08060	COG0189	ligase activity
D5E69_RS08065	COG0189	ligase activity
D5E69_RS08070	COG0189	ligase activity
D5E69_RS08075	COG4399	Belongs to the UPF0754 family
D5E69_RS08085	COG0561	phosphatase activity
D5E69_RS08090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5E69_RS08095	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS08100	COG1024	Enoyl-CoA hydratase
D5E69_RS08110	COG0420	3'-5' exonuclease activity
D5E69_RS08115	COG4717	serine-type aminopeptidase activity
D5E69_RS08120	COG3481	metal-dependent phosphohydrolase, HD sub domain
D5E69_RS08130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_RS08165	COG1846	Transcriptional regulator
D5E69_RS08170	COG4980	gas vesicle protein
D5E69_RS08185	COG0537	adenosine 5'-monophosphoramidase activity
D5E69_RS08195	COG1131	(ABC) transporter
D5E69_RS08200	COG4473	ABC transporter
D5E69_RS08220	COG3069	C4-dicarboxylate transmembrane transporter activity
D5E69_RS08225	COG2329	Antibiotic biosynthesis monooxygenase
D5E69_RS08230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5E69_RS08245	COG1309	transcriptional regulator
D5E69_RS08250	COG1511	domain protein
D5E69_RS08265	COG1234	tRNA 3'-trailer cleavage
D5E69_RS08270	COG0095	Lipoate-protein ligase
D5E69_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS08280	COG1024	Enoyl-CoA hydratase
D5E69_RS08290	COG2112	serine threonine protein kinase
D5E69_RS08295	COG2391	methyltransferase activity
D5E69_RS08300	COG1396	sequence-specific DNA binding
D5E69_RS08305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D5E69_RS08315	COG0501	Belongs to the peptidase M48B family
D5E69_RS08320	COG2323	membrane
D5E69_RS08330	COG4903	ComK protein
D5E69_RS08340	COG1506	peptidase
D5E69_RS08340	COG4946	Tricorn protease homolog
D5E69_RS08340	COG0823	Involved in the tonB-independent uptake of proteins
D5E69_RS08345	COG0398	Pfam SNARE associated Golgi protein
D5E69_RS08355	COG2356	endonuclease I
D5E69_RS08360	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D5E69_RS08365	COG1074	ATP-dependent DNA helicase activity
D5E69_RS08400	COG2311	Membrane
D5E69_RS08405	COG0179	Fumarylacetoacetate (FAA) hydrolase
D5E69_RS08420	COG0367	asparagine synthase
D5E69_RS08435	COG1562	ergosterol biosynthetic process
D5E69_RS08440	COG0004	ammonium transporteR
D5E69_RS08445	COG0347	Belongs to the P(II) protein family
D5E69_RS08450	COG0534	Mate efflux family protein
D5E69_RS08460	COG2182	Extracellular solute-binding protein
D5E69_RS08465	COG1175	transmembrane transport
D5E69_RS08470	COG3833	ABC-type maltose transport systems, permease component
D5E69_RS08475	COG0366	Alpha amylase catalytic
D5E69_RS08475	COG1874	Beta-galactosidase
D5E69_RS08480	COG1609	Transcriptional regulator
D5E69_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS08495	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5E69_RS08500	COG1666	GTP binding
D5E69_RS08510	COG1307	EDD domain protein, DegV family
D5E69_RS08515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS08525	COG0561	phosphatase activity
D5E69_RS08530	COG1073	alpha beta
D5E69_RS08535	COG2151	metal-sulfur cluster biosynthetic enzyme
D5E69_RS08540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5E69_RS08545	COG1968	undecaprenyl-diphosphatase activity
D5E69_RS08575	COG2267	carboxylic ester hydrolase activity
D5E69_RS08585	COG1744	ABC transporter substrate-binding protein PnrA-like
D5E69_RS08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS08600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5E69_RS08615	COG0180	Tryptophanyl-tRNA synthetase
D5E69_RS08625	COG4166	transmembrane transport
D5E69_RS08630	COG0601	transmembrane transport
D5E69_RS08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_RS08640	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS08645	COG4608	Belongs to the ABC transporter superfamily
D5E69_RS08655	COG0456	acetyltransferase
D5E69_RS08660	COG1393	Belongs to the ArsC family
D5E69_RS08665	COG4862	establishment of competence for transformation
D5E69_RS08670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_RS08680	COG1164	Oligoendopeptidase f
D5E69_RS08690	COG2346	COG2346, Truncated hemoglobins
D5E69_RS08695	COG0741	lytic transglycosylase activity
D5E69_RS08700	COG4116	CYTH
D5E69_RS08710	COG2357	RelA SpoT domain protein
D5E69_RS08715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5E69_RS08720	COG0564	pseudouridine synthase activity
D5E69_RS08725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5E69_RS08730	COG2239	Acts as a magnesium transporter
D5E69_RS08735	COG0475	glutathione-regulated potassium exporter activity
D5E69_RS08735	COG0569	domain protein
D5E69_RS08745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5E69_RS08775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS08800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS08805	COG2323	membrane
D5E69_RS08810	COG2153	protein acetylation
D5E69_RS08815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5E69_RS08820	COG2382	esterase
D5E69_RS08825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5E69_RS08860	COG0183	Belongs to the thiolase family
D5E69_RS08870	COG1737	Transcriptional regulator
D5E69_RS08875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D5E69_RS08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_RS08885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_RS08890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_RS08900	COG1764	response to oxidative stress
D5E69_RS08905	COG1295	ribonuclease BN
D5E69_RS08910	COG1363	Peptidase, m42
D5E69_RS08915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5E69_RS08920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5E69_RS08925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5E69_RS08930	COG2200	EAL domain
D5E69_RS08945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5E69_RS08955	COG0861	Integral membrane protein TerC family
D5E69_RS08960	COG1191	sigma factor activity
D5E69_RS08975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5E69_RS08990	COG3594	Acyltransferase
D5E69_RS08995	COG5002	protein histidine kinase activity
D5E69_RS09000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5E69_RS09005	COG0640	Transcriptional regulator
D5E69_RS09010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5E69_RS09015	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D5E69_RS09030	COG1850	ribulose-bisphosphate carboxylase activity
D5E69_RS09035	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D5E69_RS09040	COG0235	Class ii aldolase
D5E69_RS09055	COG1846	Transcriptional regulator
D5E69_RS09070	COG3949	Membrane
D5E69_RS09075	COG4873	Protein conserved in bacteria
D5E69_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS09090	COG0714	Associated with various cellular activities
D5E69_RS09115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5E69_RS09120	COG0456	acetyltransferase
D5E69_RS09125	COG0436	Aminotransferase
D5E69_RS09130	COG0598	Magnesium transport protein CorA
D5E69_RS09140	COG0720	synthase
D5E69_RS09155	COG0835	chemotaxis
D5E69_RS09155	COG0784	Response regulator, receiver
D5E69_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS09175	COG2200	EAL domain
D5E69_RS09195	COG4703	Protein of unknown function (DUF1797)
D5E69_RS09200	COG0517	IMP dehydrogenase activity
D5E69_RS09205	COG0583	DNA-binding transcription factor activity
D5E69_RS09215	COG1473	amidohydrolase
D5E69_RS09230	COG1131	(ABC) transporter
D5E69_RS09265	COG2304	oxidoreductase activity
D5E69_RS09270	COG0668	transmembrane transport
D5E69_RS09275	COG1132	(ABC) transporter
D5E69_RS09280	COG1132	(ABC) transporter
D5E69_RS09285	COG1271	oxidase subunit
D5E69_RS09290	COG1294	oxidase, subunit
D5E69_RS09300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5E69_RS09310	COG0561	phosphatase activity
D5E69_RS09330	COG0022	dehydrogenase e1 component
D5E69_RS09335	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_RS09345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS09355	COG0726	polysaccharide deacetylase
D5E69_RS09365	COG1982	Orn Lys Arg decarboxylase major
D5E69_RS09375	COG4476	Belongs to the UPF0223 family
D5E69_RS09380	COG4493	Belongs to the UPF0637 family
D5E69_RS09390	COG0483	inositol monophosphate 1-phosphatase activity
D5E69_RS09415	COG4896	Protein conserved in bacteria
D5E69_RS09430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5E69_RS09435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5E69_RS09440	COG2066	Belongs to the glutaminase family
D5E69_RS09450	COG0772	Belongs to the SEDS family
D5E69_RS09455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5E69_RS09460	COG1612	heme a metabolic process
D5E69_RS09490	COG3336	cytochrome c oxidase
D5E69_RS09515	COG2340	Cysteine-rich secretory protein family
D5E69_RS09520	COG2050	protein possibly involved in aromatic compounds catabolism
D5E69_RS09540	COG3679	Belongs to the UPF0342 family
D5E69_RS09560	COG0742	ribosomal rna small subunit methyltransferase
D5E69_RS09565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5E69_RS09570	COG3314	Sporulation integral membrane protein YlbJ
D5E69_RS09575	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5E69_RS09580	COG3480	Lon protease (S16) C-terminal proteolytic domain
D5E69_RS09590	COG1399	metal-binding, possibly nucleic acid-binding protein
D5E69_RS09600	COG1024	Enoyl-CoA hydratase
D5E69_RS09610	COG0454	-acetyltransferase
D5E69_RS09620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5E69_RS09625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5E69_RS09630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5E69_RS09645	COG2001	Belongs to the MraZ family
D5E69_RS09665	COG0768	penicillin binding
D5E69_RS09680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5E69_RS09695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5E69_RS09700	COG3879	Bacterial protein of unknown function (DUF881)
D5E69_RS09705	COG3879	Bacterial protein of unknown function (DUF881)
D5E69_RS09710	COG3856	small basic protein
D5E69_RS09715	COG0849	cell division
D5E69_RS09720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5E69_RS09730	COG1191	sigma factor activity
D5E69_RS09735	COG1191	sigma factor activity
D5E69_RS09740	COG1873	PFAM PRC-barrel domain
D5E69_RS09750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5E69_RS09755	COG1799	cell septum assembly
D5E69_RS09760	COG0762	integral membrane protein
D5E69_RS09765	COG2302	S4 RNA-binding domain
D5E69_RS09770	COG3599	regulation of cell shape
D5E69_RS09785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5E69_RS09790	COG0564	pseudouridine synthase activity
D5E69_RS09795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D5E69_RS09800	COG2233	PERMEase
D5E69_RS09810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5E69_RS09820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5E69_RS09830	COG0167	dihydroorotate dehydrogenase activity
D5E69_RS09850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5E69_RS09855	COG1561	YicC-like family, N-terminal region
D5E69_RS09860	COG2052	Domain of unknown function (DUF370)
D5E69_RS09865	COG0194	GDP metabolic process
D5E69_RS09875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5E69_RS09880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5E69_RS09885	COG0242	peptide deformylase activity
D5E69_RS09890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5E69_RS09895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5E69_RS09895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5E69_RS09900	COG0631	protein serine/threonine phosphatase activity
D5E69_RS09905	COG2815	serine threonine protein kinase
D5E69_RS09905	COG0515	serine threonine protein kinase
D5E69_RS09910	COG1162	GTPase activity
D5E69_RS09915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_RS09920	COG1564	THIamine pyrophosphokinase
D5E69_RS09930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5E69_RS09935	COG1302	Protein conserved in bacteria
D5E69_RS09940	COG1461	Dihydroxyacetone kinase
D5E69_RS09945	COG1760	l-serine dehydratase
D5E69_RS09955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5E69_RS09960	COG1349	DNA-binding transcription factor activity
D5E69_RS09965	COG0416	fatty acid biosynthetic process
D5E69_RS09970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5E69_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS09980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5E69_RS09990	COG1196	nuclear chromosome segregation
D5E69_RS09995	COG0552	protein localization to endoplasmic reticulum
D5E69_RS10000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D5E69_RS10005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5E69_RS10010	COG0228	four-way junction DNA binding
D5E69_RS10015	COG1837	Belongs to the UPF0109 family
D5E69_RS10025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5E69_RS10030	COG0336	Belongs to the RNA methyltransferase TrmD family
D5E69_RS10035	COG0335	large ribosomal subunit rRNA binding
D5E69_RS10045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5E69_RS10050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5E69_RS10060	COG2257	FlhB HrpN YscU SpaS Family
D5E69_RS10070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5E69_RS10075	COG0758	DNA mediated transformation
D5E69_RS10080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5E69_RS10085	COG4974	Belongs to the 'phage' integrase family
D5E69_RS10090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D5E69_RS10100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_RS10105	COG1815	bacterial-type flagellum-dependent cell motility
D5E69_RS10110	COG1558	bacterial-type flagellum-dependent cell motility
D5E69_RS10115	COG1677	Flagellar hook-basal body complex protein FliE
D5E69_RS10120	COG1766	The M ring may be actively involved in energy transduction
D5E69_RS10125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_RS10130	COG1317	bacterial-type flagellum organization
D5E69_RS10135	COG1157	protein secretion by the type III secretion system
D5E69_RS10140	COG2882	bacterial-type flagellum organization
D5E69_RS10150	COG3144	bacterial-type flagellum assembly
D5E69_RS10155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5E69_RS10160	COG1749	Flagellar hook protein flgE
D5E69_RS10165	COG1582	Flagellar protein (FlbD)
D5E69_RS10170	COG1580	Controls the rotational direction of flagella during chemotaxis
D5E69_RS10175	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_RS10180	COG1776	CheC inhibitor of MCP methylation
D5E69_RS10180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_RS10185	COG2201	protein-glutamate methylesterase activity
D5E69_RS10190	COG3190	flagellar
D5E69_RS10195	COG1338	Plays a role in the flagellum-specific transport system
D5E69_RS10200	COG1987	bacterial-type flagellum assembly
D5E69_RS10205	COG1684	flagellar biosynthetic protein fliR
D5E69_RS10210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5E69_RS10215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5E69_RS10220	COG1419	protein localization to endoplasmic reticulum
D5E69_RS10225	COG0455	bacterial-type flagellum organization
D5E69_RS10235	COG2198	Histidine kinase
D5E69_RS10235	COG0643	Histidine kinase
D5E69_RS10240	COG0835	chemotaxis
D5E69_RS10245	COG1776	CheC inhibitor of MCP methylation
D5E69_RS10250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5E69_RS10255	COG1191	sigma factor activity
D5E69_RS10270	COG0052	Belongs to the universal ribosomal protein uS2 family
D5E69_RS10280	COG0528	UMP kinase activity
D5E69_RS10285	COG0233	cytoplasmic translational termination
D5E69_RS10290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5E69_RS10295	COG4589	Belongs to the CDS family
D5E69_RS10305	COG0750	zinc metalloprotease
D5E69_RS10310	COG0442	prolyl-tRNA aminoacylation
D5E69_RS10315	COG2176	DNA-directed DNA polymerase activity
D5E69_RS10320	COG0779	Required for maturation of 30S ribosomal subunits
D5E69_RS10325	COG0195	Participates in both transcription termination and antitermination
D5E69_RS10330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D5E69_RS10335	COG1358	cellular component organization or biogenesis
D5E69_RS10340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5E69_RS10345	COG1550	Protein conserved in bacteria
D5E69_RS10350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5E69_RS10360	COG0196	riboflavin kinase activity
D5E69_RS10370	COG1185	polyribonucleotide nucleotidyltransferase activity
D5E69_RS10375	COG0726	polysaccharide deacetylase
D5E69_RS10380	COG0612	Peptidase, M16
D5E69_RS10385	COG1873	PFAM PRC-barrel domain
D5E69_RS10390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5E69_RS10395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5E69_RS10400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5E69_RS10405	COG0527	aspartate kinase activity
D5E69_RS10415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5E69_RS10420	COG0740	serine-type endopeptidase activity
D5E69_RS10430	COG1674	ftsk spoiiie
D5E69_RS10430	COG4980	gas vesicle protein
D5E69_RS10435	COG2188	Transcriptional regulator
D5E69_RS10460	COG0612	Peptidase, M16
D5E69_RS10465	COG0612	Peptidase, M16
D5E69_RS10470	COG0300	oxidoreductase activity
D5E69_RS10485	COG1426	Protein conserved in bacteria
D5E69_RS10490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5E69_RS10500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5E69_RS10510	COG1692	metallophosphoesterase
D5E69_RS10515	COG2359	stage V sporulation protein S
D5E69_RS10525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D5E69_RS10525	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5E69_RS10530	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5E69_RS10555	COG1216	Glycosyl transferase, family 2
D5E69_RS10560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_RS10585	COG0438	transferase activity, transferring glycosyl groups
D5E69_RS10595	COG1086	Polysaccharide biosynthesis protein
D5E69_RS10610	COG0438	transferase activity, transferring glycosyl groups
D5E69_RS10610	COG1216	Glycosyl transferase, family 2
D5E69_RS10625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5E69_RS10630	COG4550	Control of competence regulator ComK, YlbF/YmcA
D5E69_RS10640	COG0551	DNA topoisomerase type I activity
D5E69_RS10640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5E69_RS10650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5E69_RS10655	COG2720	vancomycin resistance protein
D5E69_RS10665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5E69_RS10700	COG1923	regulation of RNA biosynthetic process
D5E69_RS10705	COG0464	growth
D5E69_RS10710	COG2860	membrane
D5E69_RS10715	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D5E69_RS10720	COG0789	Transcriptional regulator
D5E69_RS10725	COG0174	glutamine synthetase
D5E69_RS10730	COG0659	secondary active sulfate transmembrane transporter activity
D5E69_RS10740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5E69_RS10745	COG1388	LysM domain
D5E69_RS10750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5E69_RS10755	COG4224	UPF0291 protein
D5E69_RS10775	COG3763	UPF0154 protein
D5E69_RS10780	COG4851	CamS sex pheromone cAM373 precursor
D5E69_RS10785	COG1132	(ABC) transporter
D5E69_RS10790	COG1132	(ABC) transporter
D5E69_RS10800	COG0785	Cytochrome C biogenesis protein
D5E69_RS10805	COG2201	protein-glutamate methylesterase activity
D5E69_RS10810	COG4846	Membrane protein involved in cytochrome C biogenesis
D5E69_RS10820	COG3852	Histidine kinase
D5E69_RS10840	COG0419	ATPase involved in DNA repair
D5E69_RS10850	COG1999	signal sequence binding
D5E69_RS10860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_RS10870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D5E69_RS10885	COG1063	alcohol dehydrogenase
D5E69_RS10895	COG0626	cystathionine gamma-synthase activity
D5E69_RS10900	COG0646	methionine synthase
D5E69_RS10900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5E69_RS10905	COG1410	methionine synthase
D5E69_RS10905	COG0646	methionine synthase
D5E69_RS10910	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_RS10920	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_RS10925	COG0346	lactoylglutathione lyase activity
D5E69_RS10930	COG0400	carboxylic ester hydrolase activity
D5E69_RS10950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5E69_RS10955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D5E69_RS10965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS10970	COG1968	undecaprenyl-diphosphatase activity
D5E69_RS10990	COG1183	phosphatidylcholine synthase activity
D5E69_RS11020	COG5566	PFAM Mor transcription activator
D5E69_RS11030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5E69_RS11035	COG1846	Transcriptional regulator
D5E69_RS11040	COG0778	Nitroreductase
D5E69_RS11060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_RS11075	COG1216	Glycosyl transferase, family 2
D5E69_RS11080	COG0438	transferase activity, transferring glycosyl groups
D5E69_RS11080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_RS11085	COG0730	response to heat
D5E69_RS11090	COG1309	transcriptional regulator
D5E69_RS11095	COG2814	Major facilitator Superfamily
D5E69_RS11115	COG1231	oxidoreductase activity
D5E69_RS11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS11145	COG0204	Acyl-transferase
D5E69_RS11170	COG1113	amino acid transport
D5E69_RS11175	COG2814	Major facilitator Superfamily
D5E69_RS11180	COG1942	4-Oxalocrotonate Tautomerase
D5E69_RS11200	COG1597	lipid kinase activity
D5E69_RS11210	COG0322	excinuclease ABC activity
D5E69_RS11220	COG3275	phosphorelay sensor kinase activity
D5E69_RS11225	COG4753	response regulator
D5E69_RS11225	COG2207	Transcriptional regulator
D5E69_RS11230	COG4977	sequence-specific DNA binding
D5E69_RS11240	COG4209	transmembrane transport
D5E69_RS11245	COG0395	ABC-type sugar transport system, permease component
D5E69_RS11255	COG1621	beta-fructofuranosidase activity
D5E69_RS11260	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D5E69_RS11265	COG1414	Transcriptional regulator
D5E69_RS11270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_RS11275	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_RS11285	COG2610	gluconate transmembrane transporter activity
D5E69_RS11290	COG0109	protoheme IX farnesyltransferase activity
D5E69_RS11295	COG1309	transcriptional regulator
D5E69_RS11300	COG0586	Pfam SNARE associated Golgi protein
D5E69_RS11330	COG0583	DNA-binding transcription factor activity
D5E69_RS11335	COG0372	Belongs to the citrate synthase family
D5E69_RS11340	COG0456	acetyltransferase
D5E69_RS11345	COG3852	Histidine kinase
D5E69_RS11380	COG1253	flavin adenine dinucleotide binding
D5E69_RS11385	COG0789	Transcriptional regulator
D5E69_RS11390	COG2362	D-Aminopeptidase
D5E69_RS11395	COG0601	transmembrane transport
D5E69_RS11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_RS11405	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS11410	COG4166	transmembrane transport
D5E69_RS11420	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_RS11425	COG0791	NLP P60 protein
D5E69_RS11440	COG0500	methyltransferase
D5E69_RS11460	COG1131	(ABC) transporter
D5E69_RS11465	COG4473	ABC transporter
D5E69_RS11470	COG0456	acetyltransferase
D5E69_RS11480	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS11490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5E69_RS11510	COG4326	sporulation control protein
D5E69_RS11545	COG2309	aminopeptidase activity
D5E69_RS11550	COG3152	Membrane
D5E69_RS11555	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D5E69_RS11560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5E69_RS11565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5E69_RS11570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5E69_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS11585	COG0006	proline dipeptidase activity
D5E69_RS11600	COG1380	Effector of murein hydrolase LrgA
D5E69_RS11605	COG1346	cytolysis
D5E69_RS11610	COG0024	Methionine aminopeptidase
D5E69_RS11615	COG1388	LysM domain
D5E69_RS11615	COG3584	3D domain protein
D5E69_RS11620	COG3584	3D domain protein
D5E69_RS11620	COG3583	domain protein
D5E69_RS11625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5E69_RS11660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5E69_RS11665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS11685	COG0824	Thioesterase
D5E69_RS11695	COG4841	protein insertion into membrane
D5E69_RS11700	COG2843	Capsule synthesis protein
D5E69_RS11705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5E69_RS11710	COG2233	PERMEase
D5E69_RS11715	COG1832	CoA-binding protein
D5E69_RS11720	COG0187	DNA topoisomerase II activity
D5E69_RS11730	COG1115	amino acid carrier protein
D5E69_RS11735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_RS11740	COG0697	spore germination
D5E69_RS11755	COG1253	flavin adenine dinucleotide binding
D5E69_RS11785	COG2814	Major facilitator Superfamily
D5E69_RS11810	COG0667	Aldo Keto reductase
D5E69_RS11815	COG1309	transcriptional regulator
D5E69_RS11820	COG0477	Major facilitator Superfamily
D5E69_RS11850	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS11870	COG0778	Nitroreductase
D5E69_RS11885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D5E69_RS11895	COG0726	polysaccharide deacetylase
D5E69_RS11900	COG0693	protein deglycase activity
D5E69_RS11920	COG0561	phosphatase activity
D5E69_RS11935	COG2190	(PTS) system
D5E69_RS11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS11935	COG1263	PTS System
D5E69_RS11940	COG1486	melibiose metabolic process
D5E69_RS11945	COG1737	Transcriptional regulator
D5E69_RS11950	COG2070	2-Nitropropane dioxygenase
D5E69_RS11955	COG2814	Major facilitator Superfamily
D5E69_RS11975	COG1174	glycine betaine transport
D5E69_RS11980	COG1125	glycine betaine transport
D5E69_RS11980	COG0517	IMP dehydrogenase activity
D5E69_RS12000	COG2233	PERMEase
D5E69_RS12005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_RS12010	COG1648	precorrin-2 dehydrogenase activity
D5E69_RS12015	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D5E69_RS12030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5E69_RS12035	COG0529	Catalyzes the synthesis of activated sulfate
D5E69_RS12045	COG0306	phosphate transporter
D5E69_RS12060	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS12065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5E69_RS12070	COG0351	phosphomethylpyrimidine kinase
D5E69_RS12075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5E69_RS12080	COG2022	thiamine diphosphate biosynthetic process
D5E69_RS12090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_RS12095	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_RS12100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5E69_RS12105	COG2197	response regulator
D5E69_RS12110	COG4585	Histidine kinase
D5E69_RS12130	COG4589	Belongs to the CDS family
D5E69_RS12145	COG0708	Exodeoxyribonuclease III
D5E69_RS12155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5E69_RS12160	COG2340	Cysteine-rich secretory protein family
D5E69_RS12165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D5E69_RS12170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5E69_RS12185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D5E69_RS12190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5E69_RS12200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5E69_RS12210	COG0693	protein deglycase activity
D5E69_RS12215	COG2084	Dehydrogenase
D5E69_RS12225	COG0745	RESPONSE REGULATOR receiver
D5E69_RS12230	COG5002	protein histidine kinase activity
D5E69_RS12235	COG4086	secreted protein
D5E69_RS12265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5E69_RS12270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5E69_RS12280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5E69_RS12305	COG1316	TRANSCRIPTIONal
D5E69_RS12315	COG1120	ATPase activity
D5E69_RS12320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS12325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS12335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_RS12360	COG2996	Protein conserved in bacteria
D5E69_RS12365	COG2252	PERMEase
D5E69_RS12380	COG0488	(ABC) transporter
D5E69_RS12385	COG0514	ATP-dependent DNA helicase (RecQ)
D5E69_RS12435	COG1686	Belongs to the peptidase S11 family
D5E69_RS12440	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D5E69_RS12445	COG3853	Toxic anion resistance protein (TelA)
D5E69_RS12450	COG4548	von Willebrand factor, type A
D5E69_RS12455	COG0714	Associated with various cellular activities
D5E69_RS12470	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D5E69_RS12470	COG2105	PFAM AIG2 family protein
D5E69_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS12485	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_RS12500	COG5002	protein histidine kinase activity
D5E69_RS12510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D5E69_RS12515	COG0432	Pfam Uncharacterised protein family UPF0047
D5E69_RS12520	COG3011	Protein conserved in bacteria
D5E69_RS12525	COG0406	alpha-ribazole phosphatase activity
D5E69_RS12550	COG1309	transcriptional regulator
D5E69_RS12555	COG2076	Multidrug Resistance protein
D5E69_RS12560	COG2076	Multidrug Resistance protein
D5E69_RS12575	COG0697	spore germination
D5E69_RS12580	COG0628	permease
D5E69_RS12585	COG2153	protein acetylation
D5E69_RS12590	COG3340	Belongs to the peptidase S51 family
D5E69_RS12595	COG2814	Major facilitator Superfamily
D5E69_RS12600	COG1278	Cold shock
D5E69_RS12660	COG4106	trans-aconitate 2-methyltransferase activity
D5E69_RS12665	COG0159	tryptophan synthase activity
D5E69_RS12680	COG0134	indole-3-glycerol-phosphate synthase activity
D5E69_RS12690	COG0512	Glutamine amidotransferase of anthranilate synthase
D5E69_RS12700	COG1233	COG1233 Phytoene dehydrogenase and related
D5E69_RS12705	COG4145	pantothenate transmembrane transporter activity
D5E69_RS12715	COG0671	phosphoesterase, PA-phosphatase related
D5E69_RS12720	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D5E69_RS12745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5E69_RS12750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5E69_RS12750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5E69_RS12755	COG0307	riboflavin synthase, alpha
D5E69_RS12760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5E69_RS12760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5E69_RS12775	COG4667	esterase of the alpha-beta hydrolase superfamily
D5E69_RS12780	COG0494	nUDIX hydrolase
D5E69_RS12800	COG0586	Pfam SNARE associated Golgi protein
D5E69_RS12830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_RS12840	COG1215	transferase activity, transferring glycosyl groups
D5E69_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS12865	COG2340	Cysteine-rich secretory protein family
D5E69_RS12880	COG0477	Major facilitator Superfamily
D5E69_RS12885	COG1846	Transcriptional regulator
D5E69_RS12890	COG0523	cobalamin synthesis protein
D5E69_RS12900	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_RS12900	COG0793	Belongs to the peptidase S41A family
D5E69_RS12910	COG1876	peptidase activity
D5E69_RS12925	COG4326	sporulation control protein
D5E69_RS12950	COG4479	Belongs to the UPF0346 family
D5E69_RS12960	COG1509	lysine 2,3-aminomutase activity
D5E69_RS12975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5E69_RS12980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5E69_RS12985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5E69_RS12990	COG0840	transmembrane signaling receptor activity
D5E69_RS13000	COG2190	(PTS) system
D5E69_RS13005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_RS13010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_RS13025	COG4698	Protein conserved in bacteria
D5E69_RS13030	COG2755	lipolytic protein G-D-S-L family
D5E69_RS13050	COG1272	protein, Hemolysin III
D5E69_RS13055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5E69_RS13075	COG2136	Putative SAM-dependent methyltransferase
D5E69_RS13075	COG2521	methyltransferase
D5E69_RS13085	COG1413	lyase activity
D5E69_RS13090	COG0488	(ABC) transporter
D5E69_RS13095	COG1418	mRNA catabolic process
D5E69_RS13115	COG2226	methyltransferase
D5E69_RS13125	COG1321	iron dependent repressor
D5E69_RS13130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5E69_RS13135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5E69_RS13135	COG1321	iron dependent repressor
D5E69_RS13140	COG1121	(ABC) transporter
D5E69_RS13145	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5E69_RS13150	COG1278	Cold shock
D5E69_RS13160	COG0328	RNA-DNA hybrid ribonuclease activity
D5E69_RS13165	COG0328	RNA-DNA hybrid ribonuclease activity
D5E69_RS13180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_RS13195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5E69_RS13205	COG1755	Isoprenylcysteine carboxyl methyltransferase
D5E69_RS13210	COG3424	synthase
D5E69_RS13215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5E69_RS13220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5E69_RS13225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D5E69_RS13230	COG1199	ATP-dependent helicase activity
D5E69_RS13240	COG0116	Belongs to the methyltransferase superfamily
D5E69_RS13250	COG3599	regulation of cell shape
D5E69_RS13255	COG4474	Belongs to the UPF0398 family
D5E69_RS13265	COG3359	exonuclease
D5E69_RS13270	COG1111	helicase
D5E69_RS13270	COG1205	dead DEAH box helicase
D5E69_RS13275	COG0071	Belongs to the small heat shock protein (HSP20) family
D5E69_RS13310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_RS13310	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5E69_RS13320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5E69_RS13325	COG3935	DnaD domain protein
D5E69_RS13350	COG1199	ATP-dependent helicase activity
D5E69_RS13350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5E69_RS13360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5E69_RS13370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D5E69_RS13370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D5E69_RS13375	COG0617	tRNA 3'-terminal CCA addition
D5E69_RS13380	COG0438	transferase activity, transferring glycosyl groups
D5E69_RS13385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_RS13390	COG1803	Methylglyoxal synthase
D5E69_RS13395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5E69_RS13400	COG1694	Mazg nucleotide pyrophosphohydrolase
D5E69_RS13410	COG2738	Putative neutral zinc metallopeptidase
D5E69_RS13420	COG4347	Protein of unknown function (DUF1405)
D5E69_RS13430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5E69_RS13470	COG0287	Prephenate dehydrogenase
D5E69_RS13475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5E69_RS13480	COG4401	Chorismate mutase type I
D5E69_RS13485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5E69_RS13490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5E69_RS13495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5E69_RS13500	COG0105	UTP biosynthetic process
D5E69_RS13510	COG2226	methyltransferase
D5E69_RS13515	COG0142	geranyltranstransferase activity
D5E69_RS13525	COG0302	gtp cyclohydrolase
D5E69_RS13530	COG0776	regulation of translation
D5E69_RS13535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5E69_RS13555	COG1160	GTP binding
D5E69_RS13585	COG0539	negative regulation of cytoplasmic translation
D5E69_RS13590	COG0204	Acyl-transferase
D5E69_RS13595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5E69_RS13615	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_RS13615	COG3773	Cell wall hydrolase
D5E69_RS13620	COG2339	peptidase activity
D5E69_RS13625	COG0252	asparaginase activity
D5E69_RS13630	COG0492	ferredoxin-NADP+ reductase activity
D5E69_RS13635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_RS13640	COG4862	establishment of competence for transformation
D5E69_RS13645	COG0789	Transcriptional regulator
D5E69_RS13650	COG1408	metallophosphoesterase
D5E69_RS13675	COG3546	catalase activity
D5E69_RS13685	COG1388	LysM domain
D5E69_RS13690	COG1266	CAAX protease self-immunity
D5E69_RS13695	COG0514	ATP-dependent DNA helicase (RecQ)
D5E69_RS13700	COG4955	Helix-turn-helix domain
D5E69_RS13705	COG1141	Ferredoxin
D5E69_RS13710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D5E69_RS13715	COG0739	heme binding
D5E69_RS13725	COG1595	DNA-templated transcription, initiation
D5E69_RS13730	COG5002	protein histidine kinase activity
D5E69_RS13735	COG0745	RESPONSE REGULATOR receiver
D5E69_RS13740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5E69_RS13745	COG1333	cytochrome c biogenesis protein
D5E69_RS13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS13755	COG1187	pseudouridine synthase activity
D5E69_RS13760	COG0700	Nucleoside recognition
D5E69_RS13770	COG1686	Belongs to the peptidase S11 family
D5E69_RS13775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5E69_RS13785	COG1547	Domain of unknown function (DUF309)
D5E69_RS13800	COG0697	spore germination
D5E69_RS13835	COG1686	Belongs to the peptidase S11 family
D5E69_RS13850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5E69_RS13855	COG4974	Belongs to the 'phage' integrase family
D5E69_RS13865	COG0735	belongs to the Fur family
D5E69_RS13870	COG1300	Membrane
D5E69_RS13885	COG0667	Aldo Keto reductase
D5E69_RS13895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5E69_RS13900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5E69_RS13910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_RS13915	COG1073	alpha beta
D5E69_RS13930	COG4918	Iron-sulphur cluster biosynthesis
D5E69_RS13945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5E69_RS13970	COG0300	oxidoreductase activity
D5E69_RS13975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS13980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5E69_RS13995	COG1234	tRNA 3'-trailer cleavage
D5E69_RS14000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5E69_RS14005	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5E69_RS14010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5E69_RS14020	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5E69_RS14025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5E69_RS14040	COG4129	membrane
D5E69_RS14045	COG1126	abc transporter atp-binding protein
D5E69_RS14050	COG0765	amino acid transport
D5E69_RS14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_RS14065	COG1703	isobutyryl-CoA mutase activity
D5E69_RS14070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS14070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS14075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS14080	COG1404	Belongs to the peptidase S8 family
D5E69_RS14080	COG4412	M6 family metalloprotease domain protein
D5E69_RS14085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_RS14090	COG0022	dehydrogenase e1 component
D5E69_RS14095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5E69_RS14105	COG3426	butyrate kinase activity
D5E69_RS14115	COG0280	phosphate acetyltransferase
D5E69_RS14120	COG3290	protein histidine kinase activity
D5E69_RS14120	COG3829	transcription factor binding
D5E69_RS14130	COG0584	glycerophosphoryl diester phosphodiesterase
D5E69_RS14140	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS14315	COG4974	Belongs to the 'phage' integrase family
D5E69_RS14390	COG0745	RESPONSE REGULATOR receiver
D5E69_RS14395	COG0750	zinc metalloprotease
D5E69_RS14410	COG0531	amino acid
D5E69_RS14415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D5E69_RS14420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5E69_RS14430	COG1722	exodeoxyribonuclease VII activity
D5E69_RS14435	COG1570	exodeoxyribonuclease VII activity
D5E69_RS14455	COG1302	Protein conserved in bacteria
D5E69_RS14460	COG0439	Biotin carboxylase
D5E69_RS14465	COG0511	ligase activity, forming carbon-carbon bonds
D5E69_RS14505	COG3854	ATPases associated with a variety of cellular activities
D5E69_RS14510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5E69_RS14515	COG0006	proline dipeptidase activity
D5E69_RS14520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5E69_RS14535	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5E69_RS14540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5E69_RS14550	COG0583	DNA-binding transcription factor activity
D5E69_RS14555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_RS14560	COG0095	Lipoate-protein ligase
D5E69_RS14565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_RS14570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5E69_RS14575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5E69_RS14580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5E69_RS14585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_RS14605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5E69_RS14625	COG4970	Tfp pilus assembly protein FimT
D5E69_RS14630	COG4537	Required for transformation and DNA binding
D5E69_RS14640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_RS14685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_RS14705	COG0411	ABC transporter
D5E69_RS14720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_RS14725	COG2030	dehydratase
D5E69_RS14740	COG0840	transmembrane signaling receptor activity
D5E69_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS14750	COG1388	LysM domain
D5E69_RS14750	COG3942	CHAP domain
D5E69_RS14760	COG1393	Belongs to the ArsC family
D5E69_RS14770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS14780	COG0011	TIGRFAM Protein of
D5E69_RS14805	COG1940	carbohydrate kinase activity
D5E69_RS14810	COG4483	Protein conserved in bacteria
D5E69_RS14815	COG0697	spore germination
D5E69_RS14825	COG0457	Tetratricopeptide repeat
D5E69_RS14825	COG0705	Rhomboid family
D5E69_RS14835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5E69_RS14840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5E69_RS14850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5E69_RS14870	COG0840	transmembrane signaling receptor activity
D5E69_RS14875	COG0704	Plays a role in the regulation of phosphate uptake
D5E69_RS14880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5E69_RS14885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5E69_RS14890	COG0581	inorganic phosphate transmembrane transporter activity
D5E69_RS14895	COG0573	inorganic phosphate transmembrane transporter activity
D5E69_RS14900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5E69_RS14910	COG0477	Major facilitator Superfamily
D5E69_RS14915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5E69_RS14920	COG2839	Protein conserved in bacteria
D5E69_RS14925	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5E69_RS14930	COG5521	maltodextrose utilization protein MalA
D5E69_RS14935	COG2814	Major facilitator Superfamily
D5E69_RS14945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5E69_RS14950	COG4709	membrane
D5E69_RS14955	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D5E69_RS14965	COG0735	belongs to the Fur family
D5E69_RS14975	COG1121	(ABC) transporter
D5E69_RS14985	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D5E69_RS14990	COG0513	Belongs to the DEAD box helicase family
D5E69_RS15000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5E69_RS15010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5E69_RS15015	COG2384	SAM-dependent methyltransferase
D5E69_RS15020	COG2010	Cytochrome c
D5E69_RS15025	COG1960	acyl-CoA dehydrogenase activity
D5E69_RS15035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5E69_RS15040	COG0358	DNA primase activity
D5E69_RS15045	COG1671	Belongs to the UPF0178 family
D5E69_RS15050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5E69_RS15055	COG0517	IMP dehydrogenase activity
D5E69_RS15060	COG0423	glycine-tRNA ligase activity
D5E69_RS15065	COG1381	Involved in DNA repair and RecF pathway recombination
D5E69_RS15080	COG0295	cytidine deaminase activity
D5E69_RS15085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5E69_RS15095	COG1480	7TM receptor with intracellular HD hydrolase
D5E69_RS15100	COG1702	phosphate starvation-inducible protein PhoH
D5E69_RS15125	COG4864	UPF0365 protein
D5E69_RS15135	COG1610	YqeY-like protein
D5E69_RS15140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5E69_RS15145	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5E69_RS15155	COG0366	Alpha amylase catalytic
D5E69_RS15160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5E69_RS15165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5E69_RS15170	COG2264	protein methyltransferase activity
D5E69_RS15175	COG0484	heat shock protein binding
D5E69_RS15185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5E69_RS15195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5E69_RS15200	COG0481	GTPase activity
D5E69_RS15210	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS15225	COG1466	dna polymerase III delta subunit
D5E69_RS15235	COG2333	competence protein COMEC
D5E69_RS15235	COG0658	competence protein
D5E69_RS15240	COG2333	competence protein COMEC
D5E69_RS15240	COG0658	competence protein
D5E69_RS15245	COG2131	deaminase
D5E69_RS15250	COG1596	polysaccharide export
D5E69_RS15250	COG1555	photosystem II stabilization
D5E69_RS15255	COG2226	methyltransferase
D5E69_RS15260	COG0799	negative regulation of ribosome biogenesis
D5E69_RS15265	COG1713	HD superfamily hydrolase involved in NAD metabolism
D5E69_RS15270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5E69_RS15275	COG1534	Rna-binding protein
D5E69_RS15285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5E69_RS15305	COG1183	phosphatidylcholine synthase activity
D5E69_RS15360	COG0626	cystathionine gamma-synthase activity
D5E69_RS15365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_RS15370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5E69_RS15375	COG2226	methyltransferase
D5E69_RS15390	COG0768	penicillin binding
D5E69_RS15395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5E69_RS15400	COG0572	uridine kinase
D5E69_RS15415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5E69_RS15420	COG3906	Belongs to the UPF0473 family
D5E69_RS15425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5E69_RS15430	COG4472	Bacterial protein of unknown function (DUF965)
D5E69_RS15440	COG0628	permease
D5E69_RS15455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5E69_RS15465	COG0482	sulfurtransferase activity
D5E69_RS15470	COG1104	cysteine desulfurase activity
D5E69_RS15475	COG1959	2 iron, 2 sulfur cluster binding
D5E69_RS15480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5E69_RS15490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D5E69_RS15495	COG1131	(ABC) transporter
D5E69_RS15500	COG1131	(ABC) transporter
D5E69_RS15505	COG1725	Transcriptional regulator
D5E69_RS15515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5E69_RS15520	COG1757	Na H antiporter
D5E69_RS15535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5E69_RS15540	COG0124	histidyl-tRNA synthetase
D5E69_RS15555	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS15555	COG3103	Sh3 type 3 domain protein
D5E69_RS15555	COG4991	sh3 domain protein
D5E69_RS15560	COG1490	D-aminoacyl-tRNA deacylase activity
D5E69_RS15565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_RS15570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_RS15575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5E69_RS15575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D5E69_RS15580	COG5416	Lipopolysaccharide assembly protein A domain
D5E69_RS15585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5E69_RS15585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5E69_RS15595	COG2244	polysaccharide biosynthetic process
D5E69_RS15600	COG2323	membrane
D5E69_RS15610	COG1862	Preprotein translocase
D5E69_RS15620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5E69_RS15635	COG0632	four-way junction helicase activity
D5E69_RS15655	COG1388	LysM domain
D5E69_RS15665	COG0157	Belongs to the NadC ModD family
D5E69_RS15670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5E69_RS15675	COG1104	cysteine desulfurase activity
D5E69_RS15680	COG1827	regulation of RNA biosynthetic process
D5E69_RS15685	COG0077	Prephenate dehydratase
D5E69_RS15690	COG4492	Belongs to the UPF0735 family
D5E69_RS15695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5E69_RS15700	COG3290	protein histidine kinase activity
D5E69_RS15705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5E69_RS15710	COG2868	ribosomal protein
D5E69_RS15715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5E69_RS15720	COG1530	ribonuclease E activity
D5E69_RS15725	COG1994	Peptidase M50
D5E69_RS15730	COG0739	heme binding
D5E69_RS15735	COG2894	cell division
D5E69_RS15740	COG0850	regulation of cytokinetic process
D5E69_RS15750	COG1792	Involved in formation and maintenance of cell shape
D5E69_RS15755	COG1077	Cell shape determining protein MreB Mrl
D5E69_RS15760	COG2003	Belongs to the UPF0758 family
D5E69_RS15790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5E69_RS15810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_RS15830	COG3706	GGDEF domain
D5E69_RS15835	COG0285	dihydrofolate synthase activity
D5E69_RS15840	COG0525	valine-tRNA ligase activity
D5E69_RS15850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_RS15855	COG1388	LysM domain
D5E69_RS15855	COG1388	LysM domain
D5E69_RS15865	COG0450	alkyl hydroperoxide reductase
D5E69_RS15875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5E69_RS15880	COG0113	porphobilinogen synthase activity
D5E69_RS15895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5E69_RS15910	COG1126	abc transporter atp-binding protein
D5E69_RS15920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_RS15925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS15940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5E69_RS15945	COG0470	DNA polymerase III
D5E69_RS15945	COG1067	ATP-dependent peptidase activity
D5E69_RS15950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5E69_RS15955	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5E69_RS15980	COG0622	Phosphoesterase
D5E69_RS15995	COG5401	PFAM Sporulation and spore germination
D5E69_RS16000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5E69_RS16005	COG1846	Transcriptional regulator
D5E69_RS16010	COG2197	response regulator
D5E69_RS16015	COG0824	Thioesterase
D5E69_RS16020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5E69_RS16025	COG1053	succinate dehydrogenase
D5E69_RS16030	COG2009	succinate dehydrogenase
D5E69_RS16035	COG1719	4-vinyl reductase, 4VR
D5E69_RS16045	COG0322	excinuclease ABC activity
D5E69_RS16055	COG3118	belongs to the thioredoxin family
D5E69_RS16060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D5E69_RS16065	COG2086	electron transfer activity
D5E69_RS16070	COG1024	Enoyl-CoA hydratase
D5E69_RS16075	COG1309	transcriptional regulator
D5E69_RS16080	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS16085	COG3766	membrane
D5E69_RS16095	COG1796	DNA polymerase
D5E69_RS16095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5E69_RS16100	COG1286	toxin biosynthetic process
D5E69_RS16105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D5E69_RS16110	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5E69_RS16115	COG0072	phenylalanine-tRNA ligase activity
D5E69_RS16115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5E69_RS16120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5E69_RS16125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5E69_RS16135	COG1335	isochorismatase
D5E69_RS16140	COG1363	Peptidase, m42
D5E69_RS16165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5E69_RS16175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5E69_RS16180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_RS16190	COG1484	DNA-dependent DNA replication
D5E69_RS16195	COG3611	Membrane attachment protein
D5E69_RS16210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5E69_RS16215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5E69_RS16220	COG0237	dephospho-CoA kinase activity
D5E69_RS16225	COG1971	Probably functions as a manganese efflux pump
D5E69_RS16230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5E69_RS16235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_RS16235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_RS16245	COG0330	HflC and HflK could
D5E69_RS16250	COG5002	protein histidine kinase activity
D5E69_RS16255	COG0745	RESPONSE REGULATOR receiver
D5E69_RS16265	COG0039	L-malate dehydrogenase activity
D5E69_RS16270	COG0538	isocitrate dehydrogenase activity
D5E69_RS16275	COG0372	Belongs to the citrate synthase family
D5E69_RS16280	COG2707	UPF0756 membrane protein
D5E69_RS16285	COG0628	permease
D5E69_RS16290	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5E69_RS16300	COG0205	6-phosphofructokinase activity
D5E69_RS16305	COG0825	malonyl-CoA metabolic process
D5E69_RS16310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5E69_RS16315	COG1725	Transcriptional regulator
D5E69_RS16320	COG0281	malic enzyme
D5E69_RS16325	COG0587	DNA-directed DNA polymerase activity
D5E69_RS16340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5E69_RS16350	COG4109	DRTGG domain
D5E69_RS16370	COG0589	response to stress
D5E69_RS16375	COG0165	Argininosuccinate lyase
D5E69_RS16380	COG0137	argininosuccinate synthase activity
D5E69_RS16400	COG0827	DNA restriction-modification system
D5E69_RS16405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5E69_RS16410	COG3874	Sporulation protein YtfJ
D5E69_RS16420	COG1714	RDD family
D5E69_RS16425	COG0616	signal peptide processing
D5E69_RS16430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5E69_RS16435	COG2962	Rard protein
D5E69_RS16440	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D5E69_RS16445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5E69_RS16455	COG0301	tRNA thio-modification
D5E69_RS16460	COG1104	cysteine desulfurase activity
D5E69_RS16465	COG1114	Component of the transport system for branched-chain amino acids
D5E69_RS16470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D5E69_RS16475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5E69_RS16480	COG1309	transcriptional regulator
D5E69_RS16485	COG1956	GAF domain-containing protein
D5E69_RS16495	COG2203	Gaf domain
D5E69_RS16495	COG2199	diguanylate cyclase activity
D5E69_RS16500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5E69_RS16515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5E69_RS16525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5E69_RS16530	COG0454	-acetyltransferase
D5E69_RS16535	COG0517	IMP dehydrogenase activity
D5E69_RS16540	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5E69_RS16545	COG3973	AAA domain
D5E69_RS16565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5E69_RS16565	COG1605	Chorismate mutase
D5E69_RS16570	COG0849	cell division
D5E69_RS16580	COG3118	belongs to the thioredoxin family
D5E69_RS16585	COG4980	gas vesicle protein
D5E69_RS16595	COG2309	aminopeptidase activity
D5E69_RS16600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5E69_RS16610	COG1674	ftsk spoiiie
D5E69_RS16615	COG1674	ftsk spoiiie
D5E69_RS16620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5E69_RS16625	COG4848	Belongs to the UPF0354 family
D5E69_RS16630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS16650	COG3104	oligopeptide transport
D5E69_RS16660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D5E69_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_RS16680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5E69_RS16690	COG0510	thiamine kinase activity
D5E69_RS16695	COG1523	belongs to the glycosyl hydrolase 13 family
D5E69_RS16700	COG1597	lipid kinase activity
D5E69_RS16715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_RS16725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_RS16730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5E69_RS16735	COG1349	DNA-binding transcription factor activity
D5E69_RS16740	COG1187	pseudouridine synthase activity
D5E69_RS16745	COG2244	polysaccharide biosynthetic process
D5E69_RS16750	COG2081	HI0933 family
D5E69_RS16760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_RS16765	COG0495	leucyl-tRNA aminoacylation
D5E69_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS16780	COG3290	protein histidine kinase activity
D5E69_RS16780	COG3829	transcription factor binding
D5E69_RS16785	COG4297	protein containing double-stranded beta helix domain
D5E69_RS16790	COG2814	Major facilitator Superfamily
D5E69_RS16800	COG1242	4 iron, 4 sulfur cluster binding
D5E69_RS16805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5E69_RS16810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5E69_RS16815	COG4412	M6 family metalloprotease domain protein
D5E69_RS16815	COG3291	Pkd domain containing protein
D5E69_RS16825	COG2267	carboxylic ester hydrolase activity
D5E69_RS16830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5E69_RS16835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5E69_RS16865	COG1268	BioY protein
D5E69_RS16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS16885	COG3878	Protein conserved in bacteria
D5E69_RS16895	COG1506	peptidase
D5E69_RS16900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5E69_RS16905	COG1116	anion transmembrane transporter activity
D5E69_RS16910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_RS16915	COG0494	nUDIX hydrolase
D5E69_RS16925	COG4824	toxin secretion phage lysis holin
D5E69_RS16935	COG1253	flavin adenine dinucleotide binding
D5E69_RS16950	COG1854	S-ribosylhomocysteine lyase activity
D5E69_RS16955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5E69_RS16965	COG1271	oxidase subunit
D5E69_RS16970	COG1294	oxidase, subunit
D5E69_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS16995	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_RS17000	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS17005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D5E69_RS17010	COG0596	Alpha beta hydrolase
D5E69_RS17015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D5E69_RS17020	COG1169	isochorismate synthase
D5E69_RS17025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5E69_RS17030	COG0058	SHG alpha-glucan phosphorylase activity
D5E69_RS17035	COG0297	glycogen (starch) synthase activity
D5E69_RS17040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5E69_RS17190	COG1285	pathogenesis
D5E69_RS17195	COG1285	pathogenesis
D5E69_RS17200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS17200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS17200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS17205	COG1105	Belongs to the carbohydrate kinase PfkB family
D5E69_RS17210	COG1349	DNA-binding transcription factor activity
D5E69_RS17215	COG1368	sulfuric ester hydrolase activity
D5E69_RS17220	COG0561	phosphatase activity
D5E69_RS17230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5E69_RS17235	COG0363	glucosamine-6-phosphate deaminase activity
D5E69_RS17240	COG0456	acetyltransferase
D5E69_RS17270	COG1966	Carbon starvation protein
D5E69_RS17275	COG3279	Response regulator of the LytR AlgR family
D5E69_RS17280	COG3275	phosphorelay sensor kinase activity
D5E69_RS17285	COG0697	spore germination
D5E69_RS17290	COG1902	pentaerythritol trinitrate reductase activity
D5E69_RS17295	COG0583	DNA-binding transcription factor activity
D5E69_RS17315	COG2304	oxidoreductase activity
D5E69_RS17320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS17325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5E69_RS17335	COG0367	asparagine synthase
D5E69_RS17345	COG1979	alcohol dehydrogenase
D5E69_RS17350	COG2155	Conserved Protein
D5E69_RS17355	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS17360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_RS17365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5E69_RS17370	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS17375	COG3829	transcription factor binding
D5E69_RS17385	COG0753	catalase activity
D5E69_RS17395	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_RS17400	COG1098	S1 RNA binding domain
D5E69_RS17410	COG0733	neurotransmitter:sodium symporter activity
D5E69_RS17415	COG1396	sequence-specific DNA binding
D5E69_RS17420	COG0436	Aminotransferase
D5E69_RS17425	COG1522	sequence-specific DNA binding
D5E69_RS17430	COG2267	carboxylic ester hydrolase activity
D5E69_RS17435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5E69_RS17440	COG2032	superoxide dismutase activity
D5E69_RS17450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5E69_RS17460	COG5018	Exonuclease
D5E69_RS17465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_RS17480	COG2111	Na H antiporter
D5E69_RS17480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5E69_RS17485	COG2111	Na H antiporter
D5E69_RS17490	COG1006	Multisubunit Na H antiporter MnhC subunit
D5E69_RS17495	COG0651	ATP synthesis coupled electron transport
D5E69_RS17500	COG1863	multisubunit Na H antiporter MnhE subunit
D5E69_RS17505	COG2212	antiporter activity
D5E69_RS17515	COG0778	Nitroreductase
D5E69_RS17520	COG4876	unkown
D5E69_RS17525	COG2050	protein possibly involved in aromatic compounds catabolism
D5E69_RS17535	COG2056	Na+-H+ antiporter family
D5E69_RS17540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5E69_RS17545	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D5E69_RS17550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS17555	COG3584	3D domain protein
D5E69_RS17570	COG2226	methyltransferase
D5E69_RS17575	COG1252	NADH dehydrogenase
D5E69_RS17580	COG0492	ferredoxin-NADP+ reductase activity
D5E69_RS17585	COG0702	epimerase
D5E69_RS17605	COG0316	Belongs to the HesB IscA family
D5E69_RS17615	COG1252	NADH dehydrogenase
D5E69_RS17620	COG4837	Protein of unknown function (DUF1462)
D5E69_RS17625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5E69_RS17630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5E69_RS17635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_RS17640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5E69_RS17655	COG0647	UMP catabolic process
D5E69_RS17660	COG2445	Protein of unknown function DUF86
D5E69_RS17675	COG4470	Protein conserved in bacteria
D5E69_RS17685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5E69_RS17700	COG0733	neurotransmitter:sodium symporter activity
D5E69_RS17705	COG1757	Na H antiporter
D5E69_RS17715	COG0737	Belongs to the 5'-nucleotidase family
D5E69_RS17720	COG1801	Protein of unknown function DUF72
D5E69_RS17730	COG0719	Fe-S assembly protein
D5E69_RS17735	COG0822	iron-sulfur transferase activity
D5E69_RS17740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5E69_RS17745	COG0719	Fe-S assembly protein
D5E69_RS17750	COG0396	ATPase activity
D5E69_RS17755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5E69_RS17760	COG1464	Belongs to the NlpA lipoprotein family
D5E69_RS17765	COG2011	ABC-type metal ion transport system permease component
D5E69_RS17770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_RS17780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS17785	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D5E69_RS17795	COG0509	glycine decarboxylation via glycine cleavage system
D5E69_RS17800	COG1393	Belongs to the ArsC family
D5E69_RS17805	COG1960	acyl-CoA dehydrogenase activity
D5E69_RS17810	COG0183	Belongs to the thiolase family
D5E69_RS17815	COG1024	Enoyl-CoA hydratase
D5E69_RS17815	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_RS17830	COG0506	proline dehydrogenase activity
D5E69_RS17840	COG5577	PFAM Coat F domain
D5E69_RS17875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS17880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_RS17885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_RS17905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS17910	COG1834	amidinotransferase
D5E69_RS17915	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS17930	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5E69_RS17940	COG1846	Transcriptional regulator
D5E69_RS17945	COG1764	response to oxidative stress
D5E69_RS17960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5E69_RS17965	COG2514	catechol 2,3-dioxygenase activity
D5E69_RS17970	COG2259	Doxx family
D5E69_RS17975	COG1733	regulation of RNA biosynthetic process
D5E69_RS17985	COG2814	Major facilitator Superfamily
D5E69_RS17990	COG1846	Transcriptional regulator
D5E69_RS18005	COG1733	regulation of RNA biosynthetic process
D5E69_RS18015	COG3403	YqcI/YcgG family
D5E69_RS18020	COG1280	lysine exporter protein (LysE YggA)
D5E69_RS18025	COG5577	PFAM Coat F domain
D5E69_RS18030	COG1376	ErfK ybiS ycfS ynhG family protein
D5E69_RS18040	COG0460	homoserine dehydrogenase
D5E69_RS18065	COG2234	aminopeptidase activity
D5E69_RS18070	COG0596	Alpha beta hydrolase
D5E69_RS18070	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_RS18080	COG0300	oxidoreductase activity
D5E69_RS18110	COG1131	(ABC) transporter
D5E69_RS18125	COG2076	Multidrug Resistance protein
D5E69_RS18160	COG0471	metal ion transport
D5E69_RS18185	COG0697	spore germination
D5E69_RS18195	COG0346	lactoylglutathione lyase activity
D5E69_RS18200	COG0346	lactoylglutathione lyase activity
D5E69_RS18220	COG1733	regulation of RNA biosynthetic process
D5E69_RS18245	COG1929	Belongs to the glycerate kinase type-1 family
D5E69_RS18255	COG3835	regulator
D5E69_RS18265	COG2244	polysaccharide biosynthetic process
D5E69_RS18315	COG2205	protein histidine kinase activity
D5E69_RS18340	COG5609	conserved protein (DUF2294)
D5E69_RS18345	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5E69_RS18350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5E69_RS18355	COG0346	lactoylglutathione lyase activity
D5E69_RS18360	COG1125	glycine betaine transport
D5E69_RS18360	COG0517	IMP dehydrogenase activity
D5E69_RS18365	COG1174	glycine betaine transport
D5E69_RS18380	COG0463	Glycosyl transferase, family 2
D5E69_RS18390	COG1091	dTDP-4-dehydrorhamnose reductase activity
D5E69_RS18405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D5E69_RS18415	COG0076	glutamate decarboxylase activity
D5E69_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS18435	COG4533	DNA binding
D5E69_RS18445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS18455	COG0028	Belongs to the TPP enzyme family
D5E69_RS18480	COG0596	Alpha beta hydrolase
D5E69_RS18500	COG3764	Sortase (surface protein transpeptidase)
D5E69_RS18540	COG0572	uridine kinase
D5E69_RS18545	COG2309	aminopeptidase activity
D5E69_RS18550	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D5E69_RS18565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5E69_RS18570	COG0557	exoribonuclease II activity
D5E69_RS18575	COG1647	Serine aminopeptidase, S33
D5E69_RS18580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5E69_RS18585	COG0148	phosphopyruvate hydratase activity
D5E69_RS18595	COG0149	triose-phosphate isomerase activity
D5E69_RS18600	COG0126	phosphoglycerate kinase activity
D5E69_RS18620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5E69_RS18635	COG1695	Transcriptional regulator
D5E69_RS18650	COG3850	Histidine kinase
D5E69_RS18650	COG5002	protein histidine kinase activity
D5E69_RS18655	COG0745	RESPONSE REGULATOR receiver
D5E69_RS18660	COG0671	phosphoesterase, PA-phosphatase related
D5E69_RS18665	COG0586	Pfam SNARE associated Golgi protein
D5E69_RS18675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_RS18680	COG0586	Pfam SNARE associated Golgi protein
D5E69_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS18705	COG2202	Pas domain
D5E69_RS18705	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_RS18715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5E69_RS18740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS18745	COG5002	protein histidine kinase activity
D5E69_RS18750	COG0745	RESPONSE REGULATOR receiver
D5E69_RS18775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS18785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5E69_RS18790	COG1660	Displays ATPase and GTPase activities
D5E69_RS18795	COG1051	belongs to the nudix hydrolase family
D5E69_RS18825	COG0492	ferredoxin-NADP+ reductase activity
D5E69_RS18830	COG0457	Tetratricopeptide repeat
D5E69_RS18835	COG0140	phosphoribosyl-ATP diphosphatase activity
D5E69_RS18835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5E69_RS18840	COG0107	imidazoleglycerol-phosphate synthase activity
D5E69_RS18850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5E69_RS18855	COG0131	Imidazoleglycerol-phosphate dehydratase
D5E69_RS18860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D5E69_RS18865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5E69_RS18870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5E69_RS18880	COG0110	maltose O-acetyltransferase activity
D5E69_RS18890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5E69_RS18905	COG1950	PFAM Membrane protein of
D5E69_RS18915	COG3595	metallopeptidase activity
D5E69_RS18920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5E69_RS18925	COG0556	nucleotide-excision repair
D5E69_RS18930	COG4897	Protein conserved in bacteria
D5E69_RS18940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5E69_RS18950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5E69_RS18955	COG0569	domain protein
D5E69_RS18965	COG1301	dicarboxylic acid transport
D5E69_RS18970	COG2059	Chromate
D5E69_RS18975	COG2059	Chromate
D5E69_RS18980	COG0405	Gamma-glutamyltransferase
D5E69_RS18985	COG4608	Belongs to the ABC transporter superfamily
D5E69_RS18990	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS19010	COG1522	sequence-specific DNA binding
D5E69_RS19015	COG1647	Serine aminopeptidase, S33
D5E69_RS19020	COG0583	DNA-binding transcription factor activity
D5E69_RS19025	COG2814	Major facilitator Superfamily
D5E69_RS19030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5E69_RS19040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5E69_RS19050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5E69_RS19055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5E69_RS19060	COG3243	poly(R)-hydroxyalkanoic acid synthase
D5E69_RS19075	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_RS19075	COG0793	Belongs to the peptidase S41A family
D5E69_RS19080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5E69_RS19095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_RS19100	COG2264	protein methyltransferase activity
D5E69_RS19115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5E69_RS19125	COG3104	oligopeptide transport
D5E69_RS19130	COG0739	heme binding
D5E69_RS19135	COG2177	Part of the ABC transporter FtsEX involved in
D5E69_RS19140	COG2884	Cell division ATP-binding protein ftsE
D5E69_RS19150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_RS19160	COG0653	protein targeting
D5E69_RS19165	COG1405	negative regulation of cell septum assembly
D5E69_RS19165	COG3012	SEC-C Motif Domain Protein
D5E69_RS19190	COG1516	flagellar protein fliS
D5E69_RS19195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D5E69_RS19200	COG1334	flagellar protein FlaG
D5E69_RS19210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5E69_RS19215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5E69_RS19220	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D5E69_RS19230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5E69_RS19235	COG1256	bacterial-type flagellum assembly
D5E69_RS19235	COG4786	Flagellar basal body rod
D5E69_RS19255	COG1040	competence protein
D5E69_RS19260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D5E69_RS19275	COG0697	spore germination
D5E69_RS19290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5E69_RS19345	COG0346	lactoylglutathione lyase activity
D5E69_RS19350	COG1227	inorganic diphosphatase activity
D5E69_RS19355	COG0768	penicillin binding
D5E69_RS19365	COG1902	pentaerythritol trinitrate reductase activity
D5E69_RS19370	COG0737	Belongs to the 5'-nucleotidase family
D5E69_RS19385	COG1464	Belongs to the NlpA lipoprotein family
D5E69_RS19390	COG2011	ABC-type metal ion transport system permease component
D5E69_RS19395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_RS19400	COG0745	RESPONSE REGULATOR receiver
D5E69_RS19405	COG3850	Histidine kinase
D5E69_RS19405	COG5002	protein histidine kinase activity
D5E69_RS19410	COG1136	(ABC) transporter
D5E69_RS19420	COG0584	glycerophosphoryl diester phosphodiesterase
D5E69_RS19430	COG0647	UMP catabolic process
D5E69_RS19440	COG3842	ATPase activity
D5E69_RS19470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5E69_RS19490	COG1653	transport
D5E69_RS19495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_RS19510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5E69_RS19515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5E69_RS19520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D5E69_RS19525	COG1473	amidohydrolase
D5E69_RS19540	COG5002	protein histidine kinase activity
D5E69_RS19570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5E69_RS19575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D5E69_RS19590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5E69_RS19600	COG4187	Peptidase family M20/M25/M40
D5E69_RS19605	COG1802	Transcriptional regulator
D5E69_RS19610	COG0277	FAD linked oxidase domain protein
D5E69_RS19615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5E69_RS19620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5E69_RS19625	COG4145	pantothenate transmembrane transporter activity
D5E69_RS19635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D5E69_RS19640	COG1802	Transcriptional regulator
D5E69_RS19645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_RS19655	COG1301	dicarboxylic acid transport
D5E69_RS19675	COG3711	transcriptional antiterminator
D5E69_RS19675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS19680	COG2723	6-phospho-beta-galactosidase activity
D5E69_RS19690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5E69_RS19695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5E69_RS19705	COG4974	Belongs to the 'phage' integrase family
D5E69_RS19870	COG3064	Membrane
D5E69_RS19885	COG0681	Belongs to the peptidase S26 family
D5E69_RS19895	COG1802	Transcriptional regulator
D5E69_RS19900	COG2084	Dehydrogenase
D5E69_RS19910	COG2610	gluconate transmembrane transporter activity
D5E69_RS19915	COG1802	Transcriptional regulator
D5E69_RS19920	COG0471	metal ion transport
D5E69_RS19925	COG0473	3-isopropylmalate dehydrogenase activity
D5E69_RS19935	COG0395	ABC-type sugar transport system, permease component
D5E69_RS19945	COG1653	transport
D5E69_RS19960	COG1404	Belongs to the peptidase S8 family
D5E69_RS19980	COG2814	Major facilitator Superfamily
D5E69_RS19985	COG3829	transcription factor binding
D5E69_RS19985	COG3290	protein histidine kinase activity
D5E69_RS19990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5E69_RS19995	COG1757	Na H antiporter
D5E69_RS20000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5E69_RS20000	COG2755	lipolytic protein G-D-S-L family
D5E69_RS20020	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS20030	COG0601	transmembrane transport
D5E69_RS20050	COG0395	ABC-type sugar transport system, permease component
D5E69_RS20055	COG4209	transmembrane transport
D5E69_RS20060	COG4753	response regulator
D5E69_RS20060	COG2207	Transcriptional regulator
D5E69_RS20065	COG2972	Histidine kinase
D5E69_RS20080	COG0383	alpha-mannosidase activity
D5E69_RS20085	COG5578	integral membrane protein
D5E69_RS20090	COG1940	carbohydrate kinase activity
D5E69_RS20095	COG2723	6-phospho-beta-galactosidase activity
D5E69_RS20100	COG1876	peptidase activity
D5E69_RS20105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS20105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS20105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_RS20110	COG3711	transcriptional antiterminator
D5E69_RS20110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_RS20115	COG1482	cell wall glycoprotein biosynthetic process
D5E69_RS20125	COG0028	Belongs to the TPP enzyme family
D5E69_RS20130	COG0069	glutamate synthase activity
D5E69_RS20140	COG3201	nicotinamide mononucleotide transporter
D5E69_RS20145	COG1335	isochorismatase
D5E69_RS20150	COG1051	belongs to the nudix hydrolase family
D5E69_RS20150	COG1056	cytidyltransferase-related domain
D5E69_RS20155	COG0702	epimerase
D5E69_RS20160	COG3290	protein histidine kinase activity
D5E69_RS20160	COG3829	transcription factor binding
D5E69_RS20165	COG2851	Citrate transporter
D5E69_RS20190	COG0596	Alpha beta hydrolase
D5E69_RS20250	COG0726	polysaccharide deacetylase
D5E69_RS20255	COG1388	LysM domain
D5E69_RS20255	COG3942	CHAP domain
D5E69_RS20305	COG1134	teichoic acid transport
D5E69_RS20310	COG1682	transport, permease protein
D5E69_RS20330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5E69_RS20340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5E69_RS20345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5E69_RS20350	COG3562	capsule polysaccharide
D5E69_RS20360	COG1263	PTS System
D5E69_RS20360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS20360	COG2190	(PTS) system
D5E69_RS20365	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_RS20370	COG2188	Transcriptional regulator
D5E69_RS20390	COG1388	LysM domain
D5E69_RS20390	COG0791	NLP P60 protein
D5E69_RS20400	COG5002	protein histidine kinase activity
D5E69_RS20420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS20420	COG1263	PTS System
D5E69_RS20425	COG0366	Alpha amylase catalytic
D5E69_RS20455	COG2188	Transcriptional regulator
D5E69_RS20460	COG2197	response regulator
D5E69_RS20465	COG4585	Histidine kinase
D5E69_RS20470	COG1739	Uncharacterized protein family UPF0029
D5E69_RS20475	COG1316	TRANSCRIPTIONal
D5E69_RS20480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5E69_RS20490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D5E69_RS20505	COG0438	transferase activity, transferring glycosyl groups
D5E69_RS20510	COG1368	sulfuric ester hydrolase activity
D5E69_RS20515	COG1368	sulfuric ester hydrolase activity
D5E69_RS20520	COG4193	domain, Protein
D5E69_RS20525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_RS20530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5E69_RS20535	COG1215	transferase activity, transferring glycosyl groups
D5E69_RS20545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_RS20550	COG1682	transport, permease protein
D5E69_RS20560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_RS20565	COG0791	NLP P60 protein
D5E69_RS20565	COG1388	LysM domain
D5E69_RS20570	COG1404	Belongs to the peptidase S8 family
D5E69_RS20590	COG0010	Belongs to the arginase family
D5E69_RS20600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D5E69_RS20605	COG2986	histidine ammonia-lyase
D5E69_RS20630	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_RS20635	COG3842	ATPase activity
D5E69_RS20640	COG4149	molybdate abc transporter
D5E69_RS20645	COG0165	Argininosuccinate lyase
D5E69_RS20665	COG1785	Belongs to the alkaline phosphatase family
D5E69_RS20670	COG4715	Zinc finger, swim domain protein
D5E69_RS20675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_RS20685	COG0629	single-stranded DNA binding
D5E69_RS20695	COG1396	sequence-specific DNA binding
D5E69_RS20715	COG3764	Sortase (surface protein transpeptidase)
D5E69_RS20730	COG4786	Flagellar basal body rod
D5E69_RS20735	COG4786	Flagellar basal body rod
D5E69_RS20740	COG1077	Cell shape determining protein MreB Mrl
D5E69_RS20745	COG1609	Transcriptional regulator
D5E69_RS20765	COG0739	heme binding
D5E69_RS20775	COG2385	sporulation resulting in formation of a cellular spore
D5E69_RS20795	COG4836	Membrane
D5E69_RS20810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5E69_RS20815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5E69_RS20820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_RS20825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5E69_RS20830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_RS20835	COG0356	it plays a direct role in the translocation of protons across the membrane
D5E69_RS20850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D5E69_RS20855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5E69_RS20860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5E69_RS20870	COG0698	ribose 5-phosphate isomerase
D5E69_RS20875	COG0840	transmembrane signaling receptor activity
D5E69_RS20885	COG1971	Probably functions as a manganese efflux pump
D5E69_RS20890	COG0246	Mannitol dehydrogenase
D5E69_RS20905	COG2755	lipolytic protein G-D-S-L family
D5E69_RS20910	COG0523	cobalamin synthesis protein
D5E69_RS20920	COG3689	TIGRFAM TIGR03943 family protein
D5E69_RS20925	COG0701	Predicted permease
D5E69_RS20935	COG0673	inositol 2-dehydrogenase activity
D5E69_RS20940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_RS20945	COG0395	ABC-type sugar transport system, permease component
D5E69_RS20950	COG1175	transmembrane transport
D5E69_RS20980	COG4753	response regulator
D5E69_RS20980	COG2207	Transcriptional regulator
D5E69_RS20985	COG2972	Histidine kinase
D5E69_RS21000	COG3718	enzyme involved in inositol metabolism
D5E69_RS21005	COG0009	L-threonylcarbamoyladenylate synthase
D5E69_RS21020	COG2890	protein-(glutamine-N5) methyltransferase activity
D5E69_RS21025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5E69_RS21035	COG1435	thymidine kinase activity
D5E69_RS21045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5E69_RS21050	COG1494	fructose-1,6-bisphosphatase
D5E69_RS21055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5E69_RS21065	COG0191	fructose-bisphosphate aldolase activity
D5E69_RS21070	COG2204	response regulator
D5E69_RS21075	COG4821	SIS domain
D5E69_RS21080	COG4211	Belongs to the binding-protein-dependent transport system permease family
D5E69_RS21085	COG1129	ABC transporter
D5E69_RS21100	COG2801	Transposase and inactivated derivatives
D5E69_RS21110	COG0504	CTP synthase activity
D5E69_RS21115	COG3343	RNA polymerase activity
D5E69_RS21120	COG1703	isobutyryl-CoA mutase activity
D5E69_RS21120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS21120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_RS21130	COG1960	acyl-CoA dehydrogenase activity
D5E69_RS21135	COG1960	acyl-CoA dehydrogenase activity
D5E69_RS21140	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_RS21145	COG0183	Belongs to the thiolase family
D5E69_RS21150	COG2181	nitrate reductase activity
D5E69_RS21150	COG0247	lactate metabolic process
D5E69_RS21155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_RS21190	COG0018	arginyl-trna synthetase
D5E69_RS21195	COG4506	Protein conserved in bacteria
D5E69_RS21200	COG0010	Belongs to the arginase family
D5E69_RS21205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5E69_RS21210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_RS21220	COG1994	Peptidase M50
D5E69_RS21230	COG3465	dGTPase activity
D5E69_RS21255	COG0280	phosphate acetyltransferase
D5E69_RS21270	COG2363	Small membrane protein
D5E69_RS21280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5E69_RS21290	COG0351	phosphomethylpyrimidine kinase
D5E69_RS21295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_RS21300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_RS21335	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS21350	COG2133	pyrroloquinoline quinone binding
D5E69_RS21355	COG0561	phosphatase activity
D5E69_RS21360	COG2031	fatty acid transporter
D5E69_RS21375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5E69_RS21380	COG4191	Histidine kinase
D5E69_RS21390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_RS21395	COG0156	8-amino-7-oxononanoate synthase activity
D5E69_RS21405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5E69_RS21415	COG2364	Membrane
D5E69_RS21420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5E69_RS21425	COG0723	plastoquinol--plastocyanin reductase activity
D5E69_RS21425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_RS21430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_RS21430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_RS21440	COG2910	NAD(P)H-binding
D5E69_RS21445	COG2814	Major facilitator Superfamily
D5E69_RS21555	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_RS21560	COG2610	gluconate transmembrane transporter activity
D5E69_RS21565	COG0583	DNA-binding transcription factor activity
D5E69_RS21590	COG1511	domain protein
D5E69_RS21595	COG0433	COG0433 Predicted ATPase
D5E69_RS21595	COG1674	ftsk spoiiie
D5E69_RS21600	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5E69_RS21605	COG5417	Belongs to the EsaB family
D5E69_RS21615	COG0745	RESPONSE REGULATOR receiver
D5E69_RS21620	COG0642	Histidine kinase
D5E69_RS21625	COG1136	(ABC) transporter
D5E69_RS21630	COG0577	efflux transmembrane transporter activity
D5E69_RS21685	COG0443	Heat shock 70 kDa protein
D5E69_RS21690	COG2214	Heat shock protein DnaJ domain protein
D5E69_RS21705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS21705	COG1263	PTS System
D5E69_RS21705	COG2190	(PTS) system
D5E69_RS21715	COG1846	Transcriptional regulator
D5E69_RS21720	COG1380	Effector of murein hydrolase LrgA
D5E69_RS21725	COG1346	cytolysis
D5E69_RS21745	COG0697	spore germination
D5E69_RS21750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5E69_RS21755	COG2723	6-phospho-beta-galactosidase activity
D5E69_RS21760	COG1263	PTS System
D5E69_RS21760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS21760	COG2190	(PTS) system
D5E69_RS21765	COG3711	transcriptional antiterminator
D5E69_RS21790	COG4565	transcriptional regulatory protein
D5E69_RS21795	COG3290	protein histidine kinase activity
D5E69_RS21800	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5E69_RS21810	COG1349	DNA-binding transcription factor activity
D5E69_RS21835	COG0456	acetyltransferase
D5E69_RS21835	COG1846	Transcriptional regulator
D5E69_RS21840	COG1621	beta-fructofuranosidase activity
D5E69_RS21845	COG1621	beta-fructofuranosidase activity
D5E69_RS21860	COG4753	response regulator
D5E69_RS21860	COG2207	Transcriptional regulator
D5E69_RS21865	COG2972	Histidine kinase
D5E69_RS21870	COG2409	Drug exporters of the RND superfamily
D5E69_RS21870	COG1033	growth of symbiont in host cell
D5E69_RS21875	COG1846	Transcriptional regulator
D5E69_RS21915	COG2135	peptidase activity
D5E69_RS21920	COG2807	transmembrane transport
D5E69_RS21925	COG2186	Transcriptional regulator
D5E69_RS21930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5E69_RS21935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5E69_RS21940	COG0640	Transcriptional regulator
D5E69_RS21945	COG0493	'glutamate synthase
D5E69_RS21945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5E69_RS21970	COG1136	(ABC) transporter
D5E69_RS21990	COG1725	Transcriptional regulator
D5E69_RS22010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_RS22015	COG0730	response to heat
D5E69_RS22040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5E69_RS22045	COG2814	Major facilitator Superfamily
D5E69_RS22070	COG1914	H( )-stimulated, divalent metal cation uptake system
D5E69_RS22080	COG0183	Belongs to the thiolase family
D5E69_RS22085	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_RS22090	COG1268	BioY protein
D5E69_RS22100	COG2723	6-phospho-beta-galactosidase activity
D5E69_RS22105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS22105	COG2190	(PTS) system
D5E69_RS22105	COG1263	PTS System
D5E69_RS22110	COG3711	transcriptional antiterminator
D5E69_RS22115	COG0697	spore germination
D5E69_RS22120	COG0789	Transcriptional regulator
D5E69_RS22135	COG1126	abc transporter atp-binding protein
D5E69_RS22140	COG0765	amino acid transport
D5E69_RS22145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_RS22150	COG3706	GGDEF domain
D5E69_RS22165	COG3395	kinase activity
D5E69_RS22170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5E69_RS22175	COG0300	oxidoreductase activity
D5E69_RS22185	COG0450	alkyl hydroperoxide reductase
D5E69_RS22195	COG1785	Belongs to the alkaline phosphatase family
D5E69_RS22200	COG1113	amino acid transport
D5E69_RS22205	COG0672	)-iron permease
D5E69_RS22215	COG4166	transmembrane transport
D5E69_RS22220	COG4608	Belongs to the ABC transporter superfamily
D5E69_RS22225	COG0444	Belongs to the ABC transporter superfamily
D5E69_RS22230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_RS22235	COG0601	transmembrane transport
D5E69_RS22240	COG2362	D-Aminopeptidase
D5E69_RS22245	COG1522	sequence-specific DNA binding
D5E69_RS22255	COG0823	Involved in the tonB-independent uptake of proteins
D5E69_RS22255	COG4946	Tricorn protease homolog
D5E69_RS22255	COG1506	peptidase
D5E69_RS22260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5E69_RS22270	COG0277	FAD linked oxidase domain protein
D5E69_RS22280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS22280	COG1263	PTS System
D5E69_RS22280	COG2190	(PTS) system
D5E69_RS22285	COG2723	6-phospho-beta-galactosidase activity
D5E69_RS22290	COG3711	transcriptional antiterminator
D5E69_RS22295	COG4682	membrane
D5E69_RS22305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5E69_RS22320	COG3142	Participates in the control of copper homeostasis
D5E69_RS22335	COG1187	pseudouridine synthase activity
D5E69_RS22340	COG1204	response to ionizing radiation
D5E69_RS22370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5E69_RS22380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5E69_RS22385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5E69_RS22390	COG4853	Protein conserved in bacteria
D5E69_RS22395	COG4863	YycH protein
D5E69_RS22400	COG5002	protein histidine kinase activity
D5E69_RS22405	COG0745	RESPONSE REGULATOR receiver
D5E69_RS22410	COG0739	heme binding
D5E69_RS22445	COG1132	(ABC) transporter
D5E69_RS22450	COG0305	Participates in initiation and elongation during chromosome replication
D5E69_RS22455	COG0359	binds to the 23S rRNA
D5E69_RS22460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D5E69_RS22465	COG4241	membrane
D5E69_RS22470	COG0840	transmembrane signaling receptor activity
D5E69_RS22480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D5E69_RS22485	COG0629	single-stranded DNA binding
D5E69_RS22490	COG0360	Binds together with S18 to 16S ribosomal RNA
D5E69_RS22495	COG0012	GTP binding
D5E69_RS22500	COG4481	Protein conserved in bacteria
D5E69_RS22505	COG0668	transmembrane transport
D5E69_RS22520	COG1811	Na channel or pump
D5E69_RS22525	COG1475	DNA binding
D5E69_RS22530	COG1192	Involved in chromosome partitioning
D5E69_RS22535	COG1475	DNA binding
D5E69_RS22540	COG0357	Ribosomal RNA small subunit methyltransferase G
D5E69_RS22550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5E69_RS22555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_RS22560	COG1847	R3H domain protein
D5E69_RS22570	COG0594	ribonuclease P activity
D5E69_RS22575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5E69_RS22595	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_RS22595	COG2247	cell wall binding repeat
D5E69_RS22730	COG1793	dna ligase
D5E69_RS22745	COG1923	regulation of RNA biosynthetic process
D5E69_RS22755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5E69_RS22760	COG2309	aminopeptidase activity
D5E69_RS22820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5E69_RS22835	COG1609	Transcriptional regulator
D5E69_RS22840	COG1263	PTS System
D5E69_RS22840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_RS22845	COG1621	beta-fructofuranosidase activity
D5E69_RS22850	COG3596	GTP binding
D5E69_RS22865	COG2205	protein histidine kinase activity
D5E69_RS22870	COG0745	RESPONSE REGULATOR receiver
D5E69_RS22875	COG1388	LysM domain
D5E69_RS22970	COG0825	malonyl-CoA metabolic process
D5E69_RS22995	COG0629	single-stranded DNA binding
D5E69_RS23215	COG4712	double-strand break repair protein
D5E69_RS23275	COG0739	heme binding
D5E69_RS23295	COG5001	Diguanylate cyclase
D5E69_RS23295	COG3706	GGDEF domain
D5E69_RS23295	COG2203	Gaf domain
D5E69_RS23295	COG4251	negative regulation of phosphorylation
D5E69_RS23305	COG4974	Belongs to the 'phage' integrase family