locus-tag	class	description
GVI46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GVI46_RS00010	COG0592	DNA-directed DNA polymerase activity
GVI46_RS00015	COG2501	S4 domain
GVI46_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GVI46_RS00025	COG0187	DNA topoisomerase II activity
GVI46_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GVI46_RS00065	COG0517	IMP dehydrogenase activity
GVI46_RS00065	COG0516	GMP reductase activity
GVI46_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GVI46_RS00095	COG1428	Deoxynucleoside kinase
GVI46_RS00100	COG1428	Deoxynucleoside kinase
GVI46_RS00105	COG1388	LysM domain
GVI46_RS00105	COG3858	chitin binding
GVI46_RS00110	COG1335	isochorismatase
GVI46_RS00115	COG0590	tRNA wobble adenosine to inosine editing
GVI46_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GVI46_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GVI46_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GVI46_RS00240	COG1982	Orn Lys Arg decarboxylase major
GVI46_RS00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GVI46_RS00250	COG3870	Protein conserved in bacteria
GVI46_RS00255	COG0470	DNA polymerase III
GVI46_RS00260	COG1774	PSP1 C-terminal conserved region
GVI46_RS00265	COG4467	Involved in initiation control of chromosome replication
GVI46_RS00270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GVI46_RS00275	COG2827	Endonuclease containing a URI domain
GVI46_RS00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GVI46_RS00285	COG2002	toxin-antitoxin pair type II binding
GVI46_RS00295	COG0084	hydrolase, TatD family'
GVI46_RS00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GVI46_RS00315	COG4466	Protein conserved in bacteria
GVI46_RS00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GVI46_RS00335	COG0251	oxidation-reduction process
GVI46_RS00340	COG2088	sporulation resulting in formation of a cellular spore
GVI46_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GVI46_RS00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GVI46_RS00360	COG0193	aminoacyl-tRNA hydrolase activity
GVI46_RS00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GVI46_RS00375	COG2002	toxin-antitoxin pair type II binding
GVI46_RS00380	COG2244	polysaccharide biosynthetic process
GVI46_RS00385	COG3956	TIGRFAM MazG family protein
GVI46_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GVI46_RS00405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GVI46_RS00410	COG1098	S1 RNA binding domain
GVI46_RS00430	COG2304	oxidoreductase activity
GVI46_RS00435	COG0515	serine threonine protein kinase
GVI46_RS00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GVI46_RS00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GVI46_RS00460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GVI46_RS00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GVI46_RS00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GVI46_RS00475	COG0512	Glutamine amidotransferase of anthranilate synthase
GVI46_RS00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GVI46_RS00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GVI46_RS00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GVI46_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GVI46_RS00520	COG3880	PFAM UvrB UvrC protein
GVI46_RS00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GVI46_RS00530	COG0542	response to heat
GVI46_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GVI46_RS00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GVI46_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
GVI46_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GVI46_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVI46_RS00565	COG1045	serine acetyltransferase
GVI46_RS00570	COG0215	cysteine-tRNA ligase activity
GVI46_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GVI46_RS00585	COG3688	RNA-binding protein containing a PIN domain
GVI46_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GVI46_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GVI46_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
GVI46_RS00615	COG0081	regulation of translation
GVI46_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GVI46_RS00630	COG2813	Specifically methylates the guanine in position
GVI46_RS00635	COG0085	RNA polymerase activity
GVI46_RS00645	COG1358	cellular component organization or biogenesis
GVI46_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GVI46_RS00655	COG0049	tRNA binding
GVI46_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GVI46_RS00670	COG0051	transcription antitermination factor activity, RNA binding
GVI46_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GVI46_RS00680	COG0088	Forms part of the polypeptide exit tunnel
GVI46_RS00685	COG0089	rRNA binding
GVI46_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GVI46_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GVI46_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GVI46_RS00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GVI46_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GVI46_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
GVI46_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GVI46_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GVI46_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GVI46_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GVI46_RS00765	COG1841	ribosomal large subunit assembly
GVI46_RS00775	COG0201	protein transport
GVI46_RS00780	COG0563	adenylate kinase activity
GVI46_RS00785	COG0024	Methionine aminopeptidase
GVI46_RS00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GVI46_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GVI46_RS00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GVI46_RS00810	COG0202	RNA polymerase activity
GVI46_RS00815	COG0203	ribosomal protein L17
GVI46_RS00820	COG1122	ATPase activity
GVI46_RS00825	COG1122	ATPase activity
GVI46_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GVI46_RS00835	COG0101	tRNA pseudouridine synthase activity
GVI46_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GVI46_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS00860	COG0489	protein tyrosine kinase activity
GVI46_RS00865	COG0583	DNA-binding transcription factor activity
GVI46_RS00875	COG2194	sulfuric ester hydrolase activity
GVI46_RS00880	COG0726	polysaccharide deacetylase
GVI46_RS00960	COG1595	DNA-templated transcription, initiation
GVI46_RS00965	COG5662	AntiSigma factor
GVI46_RS00970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GVI46_RS00980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVI46_RS00985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GVI46_RS00995	COG0791	NLP P60 protein
GVI46_RS00995	COG3103	Sh3 type 3 domain protein
GVI46_RS00995	COG1388	LysM domain
GVI46_RS01000	COG2213	PTS system mannitol-specific
GVI46_RS01000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS01005	COG3711	transcriptional antiterminator
GVI46_RS01010	COG0246	Mannitol dehydrogenase
GVI46_RS01020	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS01025	COG1970	mechanosensitive ion channel activity
GVI46_RS01030	COG1368	sulfuric ester hydrolase activity
GVI46_RS01045	COG1176	ABC-type spermidine putrescine transport system, permease component I
GVI46_RS01050	COG1177	transmembrane transport
GVI46_RS01055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GVI46_RS01065	COG0745	RESPONSE REGULATOR receiver
GVI46_RS01070	COG5002	protein histidine kinase activity
GVI46_RS01085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GVI46_RS01085	COG3976	FMN-binding domain protein
GVI46_RS01090	COG1181	Belongs to the D-alanine--D-alanine ligase family
GVI46_RS01095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GVI46_RS01100	COG0513	Belongs to the DEAD box helicase family
GVI46_RS01105	COG4294	response to UV
GVI46_RS01110	COG0705	Rhomboid family
GVI46_RS01115	COG0736	holo-[acyl-carrier-protein] synthase activity
GVI46_RS01120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GVI46_RS01125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GVI46_RS01130	COG0864	Transcriptional regulator
GVI46_RS01135	COG2337	Toxic component of a toxin-antitoxin (TA) module
GVI46_RS01140	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS01145	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS01150	COG2172	sigma factor antagonist activity
GVI46_RS01155	COG2208	phosphoserine phosphatase activity
GVI46_RS01160	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS01170	COG1191	sigma factor activity
GVI46_RS01175	COG2208	phosphoserine phosphatase activity
GVI46_RS01180	COG2183	response to ionizing radiation
GVI46_RS01275	COG0802	atpase or kinase
GVI46_RS01280	COG1214	PFAM Peptidase M22, glycoprotease
GVI46_RS01285	COG0456	acetyltransferase
GVI46_RS01295	COG0488	(ABC) transporter
GVI46_RS01300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GVI46_RS01305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVI46_RS01310	COG0805	protein transport
GVI46_RS01320	COG1266	CAAX protease self-immunity
GVI46_RS01325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GVI46_RS01335	COG0714	Associated with various cellular activities
GVI46_RS01340	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GVI46_RS01345	COG1305	Transglutaminase-like
GVI46_RS01350	COG0519	Catalyzes the synthesis of GMP from XMP
GVI46_RS01350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GVI46_RS01355	COG2252	PERMEase
GVI46_RS01410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GVI46_RS01415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GVI46_RS01420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GVI46_RS01425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GVI46_RS01430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GVI46_RS01435	COG0047	phosphoribosylformylglycinamidine synthase activity
GVI46_RS01440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GVI46_RS01445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GVI46_RS01450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GVI46_RS01455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GVI46_RS01460	COG0138	bifunctional purine biosynthesis protein purh
GVI46_RS01465	COG0151	Belongs to the GarS family
GVI46_RS01475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GVI46_RS01480	COG4496	protein, YerC YecD
GVI46_RS01485	COG0423	glycine-tRNA ligase activity
GVI46_RS01495	COG0210	DNA helicase
GVI46_RS01505	COG4851	CamS sex pheromone cAM373 precursor
GVI46_RS01515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GVI46_RS01520	COG0154	amidase activity
GVI46_RS01530	COG1597	lipid kinase activity
GVI46_RS01540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS01550	COG0166	Belongs to the GPI family
GVI46_RS01555	COG1744	ABC transporter substrate-binding protein PnrA-like
GVI46_RS01560	COG3852	Histidine kinase
GVI46_RS01565	COG0024	Methionine aminopeptidase
GVI46_RS01570	COG2706	6-phosphogluconolactonase activity
GVI46_RS01580	COG0789	Transcriptional regulator
GVI46_RS01580	COG4978	Transcriptional regulator
GVI46_RS01585	COG2814	Major facilitator Superfamily
GVI46_RS01595	COG1876	peptidase activity
GVI46_RS01600	COG1126	abc transporter atp-binding protein
GVI46_RS01605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS01610	COG0765	amino acid transport
GVI46_RS01615	COG0765	amino acid transport
GVI46_RS01620	COG1113	amino acid transport
GVI46_RS01625	COG2733	membrane
GVI46_RS01630	COG3212	peptidase
GVI46_RS01635	COG3212	peptidase
GVI46_RS01640	COG5002	protein histidine kinase activity
GVI46_RS01640	COG3850	Histidine kinase
GVI46_RS01645	COG0745	RESPONSE REGULATOR receiver
GVI46_RS01650	COG2205	protein histidine kinase activity
GVI46_RS01655	COG0745	RESPONSE REGULATOR receiver
GVI46_RS01660	COG2311	Membrane
GVI46_RS01675	COG0671	phosphoesterase, PA-phosphatase related
GVI46_RS01680	COG1764	response to oxidative stress
GVI46_RS01685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GVI46_RS01695	COG2259	Doxx family
GVI46_RS01700	COG0693	protein deglycase activity
GVI46_RS01710	COG2318	DinB family
GVI46_RS01720	COG1115	amino acid carrier protein
GVI46_RS01735	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GVI46_RS01740	COG0598	Magnesium transport protein CorA
GVI46_RS01745	COG3290	protein histidine kinase activity
GVI46_RS01750	COG4565	transcriptional regulatory protein
GVI46_RS01765	COG4191	Histidine kinase
GVI46_RS01770	COG0513	Belongs to the DEAD box helicase family
GVI46_RS01790	COG4842	Belongs to the WXG100 family
GVI46_RS01795	COG5417	Belongs to the EsaB family
GVI46_RS01800	COG4499	WXG100 protein secretion system (Wss), protein YukC
GVI46_RS01805	COG0433	COG0433 Predicted ATPase
GVI46_RS01805	COG1674	ftsk spoiiie
GVI46_RS01810	COG1511	domain protein
GVI46_RS01825	COG2356	endonuclease I
GVI46_RS01835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVI46_RS01850	COG0488	(ABC) transporter
GVI46_RS01860	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GVI46_RS01870	COG1959	2 iron, 2 sulfur cluster binding
GVI46_RS01875	COG1017	nitric oxide dioxygenase activity
GVI46_RS01875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GVI46_RS01885	COG0693	protein deglycase activity
GVI46_RS01890	COG2340	Cysteine-rich secretory protein family
GVI46_RS01895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GVI46_RS01900	COG4840	Belongs to the UPF0435 family
GVI46_RS01905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GVI46_RS01910	COG4980	gas vesicle protein
GVI46_RS01915	COG1295	ribonuclease BN
GVI46_RS01920	COG2217	Heavy metal translocating P-type atpase
GVI46_RS01930	COG0640	Transcriptional regulator
GVI46_RS01940	COG0477	Major facilitator Superfamily
GVI46_RS01950	COG3479	Phenolic acid decarboxylase
GVI46_RS01960	COG3871	stress protein (general stress protein 26)
GVI46_RS01965	COG0387	Pfam Sodium calcium exchanger
GVI46_RS01975	COG0535	radical SAM domain protein
GVI46_RS01995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVI46_RS02005	COG1113	amino acid transport
GVI46_RS02010	COG5002	protein histidine kinase activity
GVI46_RS02030	COG1090	epimerase
GVI46_RS02040	COG4221	oxidoreductase activity
GVI46_RS02060	COG1988	membrane-bound metal-dependent
GVI46_RS02065	COG1194	a g-specific adenine glycosylase
GVI46_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS02090	COG3557	Belongs to the UPF0374 family
GVI46_RS02095	COG1132	(ABC) transporter
GVI46_RS02100	COG4129	membrane
GVI46_RS02105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GVI46_RS02110	COG4555	ABC transporter
GVI46_RS02130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GVI46_RS02135	COG0735	belongs to the Fur family
GVI46_RS02250	COG3382	B3 4 domain protein
GVI46_RS02265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GVI46_RS02270	COG2766	serine protein kinase
GVI46_RS02285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GVI46_RS02300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GVI46_RS02310	COG1968	undecaprenyl-diphosphatase activity
GVI46_RS02315	COG1301	dicarboxylic acid transport
GVI46_RS02325	COG0586	Pfam SNARE associated Golgi protein
GVI46_RS02330	COG2217	Heavy metal translocating P-type atpase
GVI46_RS02335	COG0531	amino acid
GVI46_RS02355	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GVI46_RS02365	COG1175	transmembrane transport
GVI46_RS02375	COG1653	transport
GVI46_RS02380	COG0584	glycerophosphoryl diester phosphodiesterase
GVI46_RS02395	COG4948	Mandelate Racemase Muconate Lactonizing
GVI46_RS02440	COG1388	LysM domain
GVI46_RS02440	COG3584	3D domain protein
GVI46_RS02445	COG1876	peptidase activity
GVI46_RS02455	COG3103	Sh3 type 3 domain protein
GVI46_RS02460	COG0456	acetyltransferase
GVI46_RS02460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS02465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS02485	COG1609	Transcriptional regulator
GVI46_RS02490	COG2814	Major facilitator Superfamily
GVI46_RS02495	COG0673	inositol 2-dehydrogenase activity
GVI46_RS02520	COG1609	Transcriptional regulator
GVI46_RS02535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS02540	COG1522	sequence-specific DNA binding
GVI46_RS02555	COG2814	Major facilitator Superfamily
GVI46_RS02560	COG1309	transcriptional regulator
GVI46_RS02565	COG1187	pseudouridine synthase activity
GVI46_RS02575	COG1942	4-Oxalocrotonate Tautomerase
GVI46_RS02580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GVI46_RS02585	COG0747	negative chemotaxis
GVI46_RS02605	COG0084	hydrolase, TatD family'
GVI46_RS02610	COG2962	Rard protein
GVI46_RS02620	COG0628	permease
GVI46_RS02635	COG0604	alcohol dehydrogenase
GVI46_RS02640	COG1620	l-lactate permease
GVI46_RS02650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GVI46_RS02655	COG0840	transmembrane signaling receptor activity
GVI46_RS02660	COG0564	pseudouridine synthase activity
GVI46_RS02670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVI46_RS02675	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS02680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS02680	COG3153	acetyltransferase
GVI46_RS02685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GVI46_RS02690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GVI46_RS02700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GVI46_RS02705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVI46_RS02710	COG1268	BioY protein
GVI46_RS02720	COG2719	SpoVR family
GVI46_RS02730	COG1959	2 iron, 2 sulfur cluster binding
GVI46_RS02735	COG0604	alcohol dehydrogenase
GVI46_RS02745	COG1126	abc transporter atp-binding protein
GVI46_RS02750	COG0765	amino acid transport
GVI46_RS02755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS02760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GVI46_RS02765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GVI46_RS02775	COG0352	thiamine-phosphate diphosphorylase activity
GVI46_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVI46_RS02795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GVI46_RS02800	COG0351	phosphomethylpyrimidine kinase
GVI46_RS02815	COG0702	epimerase
GVI46_RS02820	COG1253	flavin adenine dinucleotide binding
GVI46_RS02835	COG3842	ATPase activity
GVI46_RS02840	COG2508	Transcriptional regulator
GVI46_RS02855	COG0189	ligase activity
GVI46_RS02860	COG0189	ligase activity
GVI46_RS02870	COG3679	Belongs to the UPF0342 family
GVI46_RS02875	COG0561	phosphatase activity
GVI46_RS02880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GVI46_RS02885	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS02890	COG1024	Enoyl-CoA hydratase
GVI46_RS02905	COG4152	abc transporter atp-binding protein
GVI46_RS02910	COG1668	transmembrane transport
GVI46_RS02920	COG3481	metal-dependent phosphohydrolase, HD sub domain
GVI46_RS02930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVI46_RS02955	COG1846	Transcriptional regulator
GVI46_RS02970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GVI46_RS02975	COG1695	Transcriptional regulator
GVI46_RS02980	COG2153	protein acetylation
GVI46_RS02985	COG2755	lipolytic protein G-D-S-L family
GVI46_RS02985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GVI46_RS02990	COG0537	adenosine 5'-monophosphoramidase activity
GVI46_RS02995	COG1131	(ABC) transporter
GVI46_RS03000	COG4473	ABC transporter
GVI46_RS03010	COG1473	amidohydrolase
GVI46_RS03015	COG0671	phosphoesterase, PA-phosphatase related
GVI46_RS03020	COG3069	C4-dicarboxylate transmembrane transporter activity
GVI46_RS03025	COG2329	Antibiotic biosynthesis monooxygenase
GVI46_RS03030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVI46_RS03035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GVI46_RS03050	COG1309	transcriptional regulator
GVI46_RS03065	COG2972	Histidine kinase
GVI46_RS03080	COG1234	tRNA 3'-trailer cleavage
GVI46_RS03085	COG0095	Lipoate-protein ligase
GVI46_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS03095	COG1024	Enoyl-CoA hydratase
GVI46_RS03210	COG0501	Belongs to the peptidase M48B family
GVI46_RS03215	COG2224	Isocitrate lyase
GVI46_RS03225	COG0823	Involved in the tonB-independent uptake of proteins
GVI46_RS03225	COG1506	peptidase
GVI46_RS03225	COG4946	Tricorn protease homolog
GVI46_RS03230	COG0398	Pfam SNARE associated Golgi protein
GVI46_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS03240	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GVI46_RS03245	COG1074	ATP-dependent DNA helicase activity
GVI46_RS03250	COG0420	3'-5' exonuclease activity
GVI46_RS03255	COG0419	ATPase involved in DNA repair
GVI46_RS03260	COG1403	HNH endonuclease
GVI46_RS03310	COG0367	asparagine synthase
GVI46_RS03325	COG1562	ergosterol biosynthetic process
GVI46_RS03330	COG0347	Belongs to the P(II) protein family
GVI46_RS03335	COG0004	ammonium transporteR
GVI46_RS03340	COG0366	Alpha amylase catalytic
GVI46_RS03340	COG1874	Beta-galactosidase
GVI46_RS03345	COG1609	Transcriptional regulator
GVI46_RS03350	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS03355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GVI46_RS03360	COG4187	Peptidase family M20/M25/M40
GVI46_RS03365	COG0833	amino acid
GVI46_RS03370	COG3829	transcription factor binding
GVI46_RS03375	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS03380	COG1666	GTP binding
GVI46_RS03385	COG2996	Protein conserved in bacteria
GVI46_RS03395	COG1307	EDD domain protein, DegV family
GVI46_RS03400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS03410	COG0561	phosphatase activity
GVI46_RS03415	COG2151	metal-sulfur cluster biosynthetic enzyme
GVI46_RS03420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GVI46_RS03425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GVI46_RS03430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GVI46_RS03435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GVI46_RS03455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GVI46_RS03470	COG0542	response to heat
GVI46_RS03485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GVI46_RS03490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GVI46_RS03495	COG2084	Dehydrogenase
GVI46_RS03505	COG2267	carboxylic ester hydrolase activity
GVI46_RS03525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GVI46_RS03530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GVI46_RS03535	COG5504	Zn-dependent protease
GVI46_RS03540	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS03545	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS03555	COG0601	transmembrane transport
GVI46_RS03570	COG0180	Tryptophanyl-tRNA synthetase
GVI46_RS03575	COG4166	transmembrane transport
GVI46_RS03580	COG0601	transmembrane transport
GVI46_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GVI46_RS03590	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS03595	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS03600	COG0456	acetyltransferase
GVI46_RS03605	COG1113	amino acid transport
GVI46_RS03610	COG0531	amino acid
GVI46_RS03615	COG1393	Belongs to the ArsC family
GVI46_RS03620	COG0583	DNA-binding transcription factor activity
GVI46_RS03635	COG0861	Integral membrane protein TerC family
GVI46_RS03640	COG4862	establishment of competence for transformation
GVI46_RS03645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS03655	COG1164	Oligoendopeptidase f
GVI46_RS03670	COG2346	COG2346, Truncated hemoglobins
GVI46_RS03675	COG0741	lytic transglycosylase activity
GVI46_RS03680	COG4116	CYTH
GVI46_RS03690	COG2357	RelA SpoT domain protein
GVI46_RS03695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GVI46_RS03700	COG0564	pseudouridine synthase activity
GVI46_RS03710	COG2239	Acts as a magnesium transporter
GVI46_RS03715	COG0569	domain protein
GVI46_RS03715	COG0475	glutathione-regulated potassium exporter activity
GVI46_RS03770	COG0210	DNA helicase
GVI46_RS03780	COG2323	membrane
GVI46_RS03785	COG2153	protein acetylation
GVI46_RS03795	COG2382	esterase
GVI46_RS03805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GVI46_RS03815	COG1737	Transcriptional regulator
GVI46_RS03820	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GVI46_RS03825	COG1070	Carbohydrate kinase
GVI46_RS03830	COG1953	Uracil, thiamine, allantoin
GVI46_RS03850	COG1522	sequence-specific DNA binding
GVI46_RS03860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GVI46_RS03875	COG3142	Participates in the control of copper homeostasis
GVI46_RS03880	COG1113	amino acid transport
GVI46_RS03895	COG1309	transcriptional regulator
GVI46_RS03900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS03900	COG3711	transcriptional antiterminator
GVI46_RS03905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GVI46_RS03910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GVI46_RS03915	COG1447	Phosphotransferase system cellobiose-specific component IIA
GVI46_RS03920	COG1486	melibiose metabolic process
GVI46_RS03925	COG3275	phosphorelay sensor kinase activity
GVI46_RS03930	COG3279	Response regulator of the LytR AlgR family
GVI46_RS03940	COG1346	cytolysis
GVI46_RS03950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVI46_RS03955	COG0243	molybdopterin cofactor binding
GVI46_RS03960	COG2223	nitrite transmembrane transporter activity
GVI46_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GVI46_RS04005	COG3527	Alpha-acetolactate decarboxylase
GVI46_RS04010	COG0028	Belongs to the TPP enzyme family
GVI46_RS04020	COG4895	conserved protein (DUF2196)
GVI46_RS04030	COG1733	regulation of RNA biosynthetic process
GVI46_RS04035	COG2814	Major facilitator Superfamily
GVI46_RS04040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS04060	COG3052	prosthetic group binding
GVI46_RS04075	COG0784	Response regulator, receiver
GVI46_RS04080	COG4191	Histidine kinase
GVI46_RS04085	COG2066	Belongs to the glutaminase family
GVI46_RS04090	COG1115	amino acid carrier protein
GVI46_RS04095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVI46_RS04105	COG4297	protein containing double-stranded beta helix domain
GVI46_RS04110	COG0531	amino acid
GVI46_RS04120	COG1607	acyl-coa hydrolase
GVI46_RS04125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GVI46_RS04140	COG0390	transport system, permease component
GVI46_RS04145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GVI46_RS04160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVI46_RS04165	COG1136	(ABC) transporter
GVI46_RS04170	COG0577	efflux transmembrane transporter activity
GVI46_RS04180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GVI46_RS04185	COG1063	alcohol dehydrogenase
GVI46_RS04200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GVI46_RS04205	COG0833	amino acid
GVI46_RS04215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GVI46_RS04220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GVI46_RS04230	COG0861	Integral membrane protein TerC family
GVI46_RS04235	COG1301	dicarboxylic acid transport
GVI46_RS04240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GVI46_RS04245	COG3290	protein histidine kinase activity
GVI46_RS04285	COG1476	TRANSCRIPTIONal
GVI46_RS04295	COG1368	sulfuric ester hydrolase activity
GVI46_RS04310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS04315	COG2040	homocysteine
GVI46_RS04320	COG0179	Fumarylacetoacetate (FAA) hydrolase
GVI46_RS04330	COG2851	Citrate transporter
GVI46_RS04335	COG3290	protein histidine kinase activity
GVI46_RS04340	COG4565	transcriptional regulatory protein
GVI46_RS04345	COG3181	Tripartite tricarboxylate transporter family receptor
GVI46_RS04355	COG0583	DNA-binding transcription factor activity
GVI46_RS04360	COG3180	Ammonia monooxygenase
GVI46_RS04365	COG2226	methyltransferase
GVI46_RS04375	COG4175	Glycine betaine
GVI46_RS04375	COG0517	IMP dehydrogenase activity
GVI46_RS04380	COG2113	Glycine betaine
GVI46_RS04385	COG1309	transcriptional regulator
GVI46_RS04405	COG0531	amino acid
GVI46_RS04410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GVI46_RS04415	COG1464	Belongs to the NlpA lipoprotein family
GVI46_RS04420	COG2011	ABC-type metal ion transport system permease component
GVI46_RS04425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GVI46_RS04440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS04450	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GVI46_RS04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS04460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS04485	COG1737	Transcriptional regulator
GVI46_RS04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS04490	COG1263	PTS System
GVI46_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVI46_RS04505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GVI46_RS04510	COG1116	anion transmembrane transporter activity
GVI46_RS04515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GVI46_RS04520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GVI46_RS04530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GVI46_RS04535	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GVI46_RS04540	COG1733	regulation of RNA biosynthetic process
GVI46_RS04575	COG1511	domain protein
GVI46_RS04585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GVI46_RS04590	COG1733	regulation of RNA biosynthetic process
GVI46_RS04600	COG1132	(ABC) transporter
GVI46_RS04605	COG1132	(ABC) transporter
GVI46_RS04615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVI46_RS04620	COG3162	membrane
GVI46_RS04630	COG1414	Transcriptional regulator
GVI46_RS04635	COG0656	L-ascorbic acid biosynthetic process
GVI46_RS04640	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GVI46_RS04645	COG1846	Transcriptional regulator
GVI46_RS04650	COG1566	PFAM secretion protein HlyD family protein
GVI46_RS04655	COG2814	Major facilitator Superfamily
GVI46_RS04660	COG0655	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS04675	COG1609	Transcriptional regulator
GVI46_RS04680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS04690	COG1129	ABC transporter
GVI46_RS04695	COG1172	Belongs to the binding-protein-dependent transport system permease family
GVI46_RS04700	COG1879	ABC-type sugar transport system periplasmic component
GVI46_RS04705	COG3584	3D domain protein
GVI46_RS04705	COG3583	domain protein
GVI46_RS04710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GVI46_RS04715	COG1653	transport
GVI46_RS04740	COG3706	GGDEF domain
GVI46_RS04740	COG0745	RESPONSE REGULATOR receiver
GVI46_RS04760	COG0745	RESPONSE REGULATOR receiver
GVI46_RS04765	COG5002	protein histidine kinase activity
GVI46_RS04800	COG0402	S-adenosylhomocysteine deaminase activity
GVI46_RS04805	COG2252	PERMEase
GVI46_RS04815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GVI46_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS04830	COG0710	3-dehydroquinate dehydratase activity
GVI46_RS04840	COG1263	PTS System
GVI46_RS04840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS04845	COG0366	Alpha amylase catalytic
GVI46_RS04850	COG2188	Transcriptional regulator
GVI46_RS04855	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GVI46_RS04860	COG1984	allophanate hydrolase subunit 2
GVI46_RS04865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GVI46_RS04870	COG1914	H( )-stimulated, divalent metal cation uptake system
GVI46_RS04875	COG1272	protein, Hemolysin III
GVI46_RS04890	COG0778	Nitroreductase
GVI46_RS04895	COG0628	permease
GVI46_RS04915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GVI46_RS04920	COG2271	Major facilitator Superfamily
GVI46_RS04925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GVI46_RS04930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GVI46_RS04935	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS04945	COG0402	S-adenosylhomocysteine deaminase activity
GVI46_RS04950	COG1278	Cold shock
GVI46_RS04955	COG2910	NAD(P)H-binding
GVI46_RS04960	COG0673	inositol 2-dehydrogenase activity
GVI46_RS04965	COG0450	alkyl hydroperoxide reductase
GVI46_RS04970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS05000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVI46_RS05005	COG2076	Multidrug Resistance protein
GVI46_RS05010	COG2076	Multidrug Resistance protein
GVI46_RS05080	COG1649	PFAM Uncharacterised BCR, COG1649
GVI46_RS05085	COG1737	Transcriptional regulator
GVI46_RS05105	COG1486	melibiose metabolic process
GVI46_RS05115	COG1447	Phosphotransferase system cellobiose-specific component IIA
GVI46_RS05125	COG2971	BadF BadG BcrA BcrD
GVI46_RS05130	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GVI46_RS05135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS05145	COG3037	sugar-specific permease SgaT UlaA
GVI46_RS05150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GVI46_RS05150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS05160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GVI46_RS05175	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS05185	COG0583	DNA-binding transcription factor activity
GVI46_RS05195	COG0667	Aldo Keto reductase
GVI46_RS05210	COG0154	amidase activity
GVI46_RS05220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GVI46_RS05260	COG2199	diguanylate cyclase activity
GVI46_RS05260	COG2200	EAL domain
GVI46_RS05270	COG1733	regulation of RNA biosynthetic process
GVI46_RS05285	COG0385	Bile acid
GVI46_RS05295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVI46_RS05300	COG4191	Histidine kinase
GVI46_RS05305	COG0784	Response regulator, receiver
GVI46_RS05320	COG1388	LysM domain
GVI46_RS05320	COG0791	NLP P60 protein
GVI46_RS05330	COG2385	sporulation resulting in formation of a cellular spore
GVI46_RS05335	COG0656	L-ascorbic acid biosynthetic process
GVI46_RS05350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GVI46_RS05355	COG4948	Mandelate Racemase Muconate Lactonizing
GVI46_RS05390	COG0477	Major facilitator Superfamily
GVI46_RS05395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GVI46_RS05405	COG0640	Transcriptional regulator
GVI46_RS05410	COG5658	integral membrane protein
GVI46_RS05430	COG5001	Diguanylate cyclase
GVI46_RS05430	COG3300	MHYT domain
GVI46_RS05435	COG0302	gtp cyclohydrolase
GVI46_RS05450	COG5001	Diguanylate cyclase
GVI46_RS05450	COG3300	MHYT domain
GVI46_RS05455	COG0531	amino acid
GVI46_RS05475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GVI46_RS05510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GVI46_RS05520	COG1396	sequence-specific DNA binding
GVI46_RS05540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GVI46_RS05560	COG1215	transferase activity, transferring glycosyl groups
GVI46_RS05575	COG2247	cell wall binding repeat
GVI46_RS05575	COG2385	sporulation resulting in formation of a cellular spore
GVI46_RS05585	COG4464	protein tyrosine phosphatase activity
GVI46_RS05590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVI46_RS05595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GVI46_RS05600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GVI46_RS05605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GVI46_RS05625	COG0438	transferase activity, transferring glycosyl groups
GVI46_RS05630	COG0438	transferase activity, transferring glycosyl groups
GVI46_RS05645	COG1215	transferase activity, transferring glycosyl groups
GVI46_RS05665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GVI46_RS05685	COG1482	cell wall glycoprotein biosynthetic process
GVI46_RS05690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVI46_RS05695	COG3944	biosynthesis protein
GVI46_RS05700	COG0489	protein tyrosine kinase activity
GVI46_RS05705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVI46_RS05720	COG1216	Glycosyl transferase, family 2
GVI46_RS05720	COG1442	glycosyl transferase family 8
GVI46_RS05740	COG1682	transport, permease protein
GVI46_RS05745	COG1134	teichoic acid transport
GVI46_RS05750	COG1316	TRANSCRIPTIONal
GVI46_RS05770	COG0028	Belongs to the TPP enzyme family
GVI46_RS05775	COG0069	glutamate synthase activity
GVI46_RS05785	COG2084	Dehydrogenase
GVI46_RS05815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVI46_RS05820	COG2146	nitrite reductase [NAD(P)H] activity
GVI46_RS05830	COG2116	formate transmembrane transporter activity
GVI46_RS05840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS05845	COG4975	Glucose uptake
GVI46_RS05860	COG0534	Mate efflux family protein
GVI46_RS05870	COG1316	TRANSCRIPTIONal
GVI46_RS05880	COG0598	Magnesium transport protein CorA
GVI46_RS05885	COG1404	Belongs to the peptidase S8 family
GVI46_RS05910	COG4821	SIS domain
GVI46_RS05920	COG0363	glucosamine-6-phosphate deaminase activity
GVI46_RS05925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GVI46_RS05930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS05930	COG1263	PTS System
GVI46_RS05930	COG2190	(PTS) system
GVI46_RS05935	COG1811	Na channel or pump
GVI46_RS05940	COG3961	Belongs to the TPP enzyme family
GVI46_RS05975	COG1131	(ABC) transporter
GVI46_RS05980	COG1253	flavin adenine dinucleotide binding
GVI46_RS05985	COG0789	Transcriptional regulator
GVI46_RS05995	COG0346	lactoylglutathione lyase activity
GVI46_RS06000	COG2105	PFAM AIG2 family protein
GVI46_RS06000	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GVI46_RS06060	COG4187	Peptidase family M20/M25/M40
GVI46_RS06075	COG0456	acetyltransferase
GVI46_RS06075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GVI46_RS06095	COG2252	PERMEase
GVI46_RS06105	COG3279	Response regulator of the LytR AlgR family
GVI46_RS06110	COG4555	ABC transporter
GVI46_RS06115	COG1668	transmembrane transport
GVI46_RS06125	COG0789	Transcriptional regulator
GVI46_RS06130	COG1846	Transcriptional regulator
GVI46_RS06135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVI46_RS06135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVI46_RS06155	COG1785	Belongs to the alkaline phosphatase family
GVI46_RS06160	COG3279	Response regulator of the LytR AlgR family
GVI46_RS06165	COG0784	Response regulator, receiver
GVI46_RS06165	COG2205	protein histidine kinase activity
GVI46_RS06170	COG0861	Integral membrane protein TerC family
GVI46_RS06175	COG1191	sigma factor activity
GVI46_RS06205	COG3243	poly(R)-hydroxyalkanoic acid synthase
GVI46_RS06210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GVI46_RS06220	COG2186	Transcriptional regulator
GVI46_RS06225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GVI46_RS06235	COG0247	lactate metabolic process
GVI46_RS06240	COG1139	Iron-sulfur cluster binding protein
GVI46_RS06245	COG1556	Lactate utilization protein
GVI46_RS06250	COG5002	protein histidine kinase activity
GVI46_RS06255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GVI46_RS06260	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GVI46_RS06265	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GVI46_RS06270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS06275	COG0436	Aminotransferase
GVI46_RS06280	COG1850	ribulose-bisphosphate carboxylase activity
GVI46_RS06285	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GVI46_RS06290	COG0235	Class ii aldolase
GVI46_RS06295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GVI46_RS06305	COG1129	ABC transporter
GVI46_RS06310	COG1172	Belongs to the binding-protein-dependent transport system permease family
GVI46_RS06335	COG1846	Transcriptional regulator
GVI46_RS06345	COG4191	Histidine kinase
GVI46_RS06355	COG0542	response to heat
GVI46_RS06370	COG0300	oxidoreductase activity
GVI46_RS06375	COG0697	spore germination
GVI46_RS06395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GVI46_RS06400	COG0720	synthase
GVI46_RS06410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GVI46_RS06415	COG0702	epimerase
GVI46_RS06425	COG4873	Protein conserved in bacteria
GVI46_RS06445	COG3773	Cell wall hydrolase
GVI46_RS06485	COG0646	methionine synthase
GVI46_RS06485	COG1410	methionine synthase
GVI46_RS06490	COG0646	methionine synthase
GVI46_RS06490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GVI46_RS06495	COG3949	Membrane
GVI46_RS06505	COG0307	riboflavin synthase, alpha
GVI46_RS06515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GVI46_RS06525	COG3711	transcriptional antiterminator
GVI46_RS06530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS06530	COG1263	PTS System
GVI46_RS06530	COG2190	(PTS) system
GVI46_RS06545	COG1346	cytolysis
GVI46_RS06555	COG0583	DNA-binding transcription factor activity
GVI46_RS06565	COG0456	acetyltransferase
GVI46_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS06575	COG0778	Nitroreductase
GVI46_RS06580	COG0436	Aminotransferase
GVI46_RS06600	COG0784	Response regulator, receiver
GVI46_RS06600	COG0835	chemotaxis
GVI46_RS06610	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS06630	COG1408	metallophosphoesterase
GVI46_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS06640	COG2200	EAL domain
GVI46_RS06655	COG4703	Protein of unknown function (DUF1797)
GVI46_RS06660	COG0517	IMP dehydrogenase activity
GVI46_RS06665	COG0583	DNA-binding transcription factor activity
GVI46_RS06670	COG2171	N-acyltransferase activity
GVI46_RS06675	COG1473	amidohydrolase
GVI46_RS06685	COG0668	transmembrane transport
GVI46_RS06690	COG0450	alkyl hydroperoxide reductase
GVI46_RS06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS06700	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GVI46_RS06705	COG1132	(ABC) transporter
GVI46_RS06710	COG1132	(ABC) transporter
GVI46_RS06715	COG0569	domain protein
GVI46_RS06720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GVI46_RS06730	COG0561	phosphatase activity
GVI46_RS06755	COG0022	dehydrogenase e1 component
GVI46_RS06760	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVI46_RS06785	COG1982	Orn Lys Arg decarboxylase major
GVI46_RS06790	COG4476	Belongs to the UPF0223 family
GVI46_RS06795	COG4493	Belongs to the UPF0637 family
GVI46_RS06805	COG0483	inositol monophosphate 1-phosphatase activity
GVI46_RS06830	COG4896	Protein conserved in bacteria
GVI46_RS06845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GVI46_RS06850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GVI46_RS06855	COG4838	Belongs to the UPF0358 family
GVI46_RS06860	COG0772	Belongs to the SEDS family
GVI46_RS06865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GVI46_RS06870	COG1612	heme a metabolic process
GVI46_RS06875	COG0109	protoheme IX farnesyltransferase activity
GVI46_RS06900	COG3336	cytochrome c oxidase
GVI46_RS06910	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GVI46_RS06915	COG2340	Cysteine-rich secretory protein family
GVI46_RS06925	COG2738	Putative neutral zinc metallopeptidase
GVI46_RS06930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS06935	COG1694	Mazg nucleotide pyrophosphohydrolase
GVI46_RS06940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GVI46_RS06945	COG1803	Methylglyoxal synthase
GVI46_RS06950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GVI46_RS06955	COG0438	transferase activity, transferring glycosyl groups
GVI46_RS06960	COG0617	tRNA 3'-terminal CCA addition
GVI46_RS06965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GVI46_RS06965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GVI46_RS06975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GVI46_RS06980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GVI46_RS06985	COG1199	ATP-dependent helicase activity
GVI46_RS06985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GVI46_RS07005	COG0436	Aminotransferase
GVI46_RS07010	COG0017	Asparaginyl-tRNA synthetase
GVI46_RS07015	COG3935	DnaD domain protein
GVI46_RS07020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GVI46_RS07030	COG4499	WXG100 protein secretion system (Wss), protein YukC
GVI46_RS07030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVI46_RS07035	COG3331	DNA recombination
GVI46_RS07070	COG5337	Spore coat protein CotH
GVI46_RS07085	COG0626	cystathionine gamma-synthase activity
GVI46_RS07090	COG0626	cystathionine gamma-synthase activity
GVI46_RS07105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVI46_RS07115	COG1278	Cold shock
GVI46_RS07125	COG3706	GGDEF domain
GVI46_RS07135	COG1205	dead DEAH box helicase
GVI46_RS07135	COG1111	helicase
GVI46_RS07140	COG3359	exonuclease
GVI46_RS07150	COG4474	Belongs to the UPF0398 family
GVI46_RS07155	COG3599	regulation of cell shape
GVI46_RS07185	COG2197	response regulator
GVI46_RS07190	COG0366	Alpha amylase catalytic
GVI46_RS07195	COG0116	Belongs to the methyltransferase superfamily
GVI46_RS07210	COG1175	transmembrane transport
GVI46_RS07220	COG3842	ATPase activity
GVI46_RS07230	COG1199	ATP-dependent helicase activity
GVI46_RS07235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GVI46_RS07240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GVI46_RS07245	COG2233	PERMEase
GVI46_RS07250	COG0583	DNA-binding transcription factor activity
GVI46_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS07265	COG3424	synthase
GVI46_RS07270	COG1755	Isoprenylcysteine carboxyl methyltransferase
GVI46_RS07275	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GVI46_RS07280	COG3541	Predicted nucleotidyltransferase
GVI46_RS07305	COG0328	RNA-DNA hybrid ribonuclease activity
GVI46_RS07310	COG0328	RNA-DNA hybrid ribonuclease activity
GVI46_RS07335	COG2814	Major facilitator Superfamily
GVI46_RS07345	COG2233	PERMEase
GVI46_RS07350	COG2362	D-Aminopeptidase
GVI46_RS07355	COG0601	transmembrane transport
GVI46_RS07360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GVI46_RS07365	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS07370	COG4166	transmembrane transport
GVI46_RS07375	COG1619	proteins homologs of microcin C7 resistance protein MccF
GVI46_RS07380	COG0791	NLP P60 protein
GVI46_RS07385	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS07405	COG3300	MHYT domain
GVI46_RS07405	COG5001	Diguanylate cyclase
GVI46_RS07430	COG2197	response regulator
GVI46_RS07435	COG4585	Histidine kinase
GVI46_RS07440	COG3239	Fatty acid desaturase
GVI46_RS07445	COG2205	protein histidine kinase activity
GVI46_RS07455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS07470	COG1388	LysM domain
GVI46_RS07470	COG0791	NLP P60 protein
GVI46_RS07475	COG1819	glycosyl
GVI46_RS07480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVI46_RS07495	COG2814	Major facilitator Superfamily
GVI46_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS07510	COG3964	amidohydrolase
GVI46_RS07530	COG2188	Transcriptional regulator
GVI46_RS07540	COG0434	BtpA family
GVI46_RS07545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GVI46_RS07555	COG1785	Belongs to the alkaline phosphatase family
GVI46_RS07560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GVI46_RS07565	COG1404	Belongs to the peptidase S8 family
GVI46_RS07575	COG1846	Transcriptional regulator
GVI46_RS07580	COG1566	PFAM secretion protein HlyD family protein
GVI46_RS07585	COG2814	Major facilitator Superfamily
GVI46_RS07590	COG1846	Transcriptional regulator
GVI46_RS07610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS07615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS07620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GVI46_RS07625	COG1120	ATPase activity
GVI46_RS07640	COG2814	Major facilitator Superfamily
GVI46_RS07660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GVI46_RS07665	COG1733	regulation of RNA biosynthetic process
GVI46_RS07670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GVI46_RS07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVI46_RS07690	COG4175	Glycine betaine
GVI46_RS07690	COG3448	diguanylate cyclase activity
GVI46_RS07695	COG4176	ABC-type proline glycine betaine transport system permease component
GVI46_RS07710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GVI46_RS07715	COG2208	phosphoserine phosphatase activity
GVI46_RS07725	COG0531	amino acid
GVI46_RS07735	COG1011	Hydrolase
GVI46_RS07740	COG0405	Gamma-glutamyltransferase
GVI46_RS07750	COG1621	beta-fructofuranosidase activity
GVI46_RS07755	COG1621	beta-fructofuranosidase activity
GVI46_RS07760	COG2193	ferroxidase activity
GVI46_RS07765	COG0477	Major facilitator Superfamily
GVI46_RS07770	COG0156	8-amino-7-oxononanoate synthase activity
GVI46_RS07775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GVI46_RS07785	COG2814	Major facilitator Superfamily
GVI46_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS07805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS07815	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS07820	COG1113	amino acid transport
GVI46_RS07830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GVI46_RS07860	COG1113	amino acid transport
GVI46_RS07880	COG1609	Transcriptional regulator
GVI46_RS07885	COG2223	nitrite transmembrane transporter activity
GVI46_RS07895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GVI46_RS07900	COG1621	beta-fructofuranosidase activity
GVI46_RS07905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GVI46_RS07905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GVI46_RS07910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS07915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS07920	COG3715	PTS system
GVI46_RS07925	COG3716	PTS system mannose fructose sorbose family IID component
GVI46_RS07930	COG1621	beta-fructofuranosidase activity
GVI46_RS07935	COG0765	amino acid transport
GVI46_RS07940	COG0765	amino acid transport
GVI46_RS07945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS07950	COG1464	Belongs to the NlpA lipoprotein family
GVI46_RS07955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GVI46_RS07960	COG2011	ABC-type metal ion transport system permease component
GVI46_RS07980	COG1464	Belongs to the NlpA lipoprotein family
GVI46_RS07985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GVI46_RS07990	COG2011	ABC-type metal ion transport system permease component
GVI46_RS07995	COG1464	Belongs to the NlpA lipoprotein family
GVI46_RS08005	COG0024	Methionine aminopeptidase
GVI46_RS08025	COG0596	Alpha beta hydrolase
GVI46_RS08030	COG0697	spore germination
GVI46_RS08045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GVI46_RS08050	COG0531	amino acid
GVI46_RS08065	COG2723	6-phospho-beta-galactosidase activity
GVI46_RS08070	COG2188	Transcriptional regulator
GVI46_RS08085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GVI46_RS08095	COG0656	L-ascorbic acid biosynthetic process
GVI46_RS08100	COG2986	histidine ammonia-lyase
GVI46_RS08105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GVI46_RS08110	COG1228	amidohydrolase
GVI46_RS08115	COG0010	Belongs to the arginase family
GVI46_RS08120	COG1846	Transcriptional regulator
GVI46_RS08125	COG1957	nucleoside hydrolase
GVI46_RS08130	COG0473	3-isopropylmalate dehydrogenase activity
GVI46_RS08135	COG1288	antiporter activity
GVI46_RS08140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GVI46_RS08170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS08190	COG2364	Membrane
GVI46_RS08195	COG1846	Transcriptional regulator
GVI46_RS08200	COG0456	acetyltransferase
GVI46_RS08235	COG3848	Pyruvate phosphate dikinase
GVI46_RS08235	COG0574	Belongs to the PEP-utilizing enzyme family
GVI46_RS08240	COG1309	transcriptional regulator
GVI46_RS08245	COG2814	Major facilitator Superfamily
GVI46_RS08250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GVI46_RS08255	COG3958	Transketolase
GVI46_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS08265	COG2186	Transcriptional regulator
GVI46_RS08285	COG0698	ribose 5-phosphate isomerase
GVI46_RS08310	COG1388	LysM domain
GVI46_RS08310	COG0791	NLP P60 protein
GVI46_RS08315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GVI46_RS08330	COG2318	DinB family
GVI46_RS08350	COG0583	DNA-binding transcription factor activity
GVI46_RS08355	COG0596	Alpha beta hydrolase
GVI46_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS08400	COG0726	polysaccharide deacetylase
GVI46_RS08405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GVI46_RS08415	COG0697	spore germination
GVI46_RS08420	COG4977	sequence-specific DNA binding
GVI46_RS08430	COG0387	Pfam Sodium calcium exchanger
GVI46_RS08435	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS08450	COG1309	transcriptional regulator
GVI46_RS08455	COG0861	Integral membrane protein TerC family
GVI46_RS08465	COG5577	PFAM Coat F domain
GVI46_RS08475	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS08485	COG1522	sequence-specific DNA binding
GVI46_RS08490	COG3813	Protein conserved in bacteria
GVI46_RS08515	COG2076	Multidrug Resistance protein
GVI46_RS08530	COG1278	Cold shock
GVI46_RS08540	COG0513	Belongs to the DEAD box helicase family
GVI46_RS08545	COG1278	Cold shock
GVI46_RS08560	COG0028	Belongs to the TPP enzyme family
GVI46_RS08595	COG0747	negative chemotaxis
GVI46_RS08600	COG0601	transmembrane transport
GVI46_RS08605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GVI46_RS08610	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS08615	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS08620	COG0534	Mate efflux family protein
GVI46_RS08640	COG2172	sigma factor antagonist activity
GVI46_RS08650	COG0477	Major facilitator Superfamily
GVI46_RS08655	COG3858	chitin binding
GVI46_RS08655	COG1388	LysM domain
GVI46_RS08660	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS08690	COG2226	methyltransferase
GVI46_RS08705	COG1733	regulation of RNA biosynthetic process
GVI46_RS08710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS08725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS08730	COG3420	alginic acid biosynthetic process
GVI46_RS08750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GVI46_RS08755	COG0640	Transcriptional regulator
GVI46_RS08760	COG0640	Transcriptional regulator
GVI46_RS08765	COG0346	lactoylglutathione lyase activity
GVI46_RS08770	COG0475	glutathione-regulated potassium exporter activity
GVI46_RS08770	COG0589	response to stress
GVI46_RS08780	COG3011	Protein conserved in bacteria
GVI46_RS08805	COG0583	DNA-binding transcription factor activity
GVI46_RS08810	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GVI46_RS08820	COG0753	catalase activity
GVI46_RS08835	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS08840	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS08860	COG0384	phenazine biosynthesis protein PhzF
GVI46_RS08870	COG5577	PFAM Coat F domain
GVI46_RS08880	COG1063	alcohol dehydrogenase
GVI46_RS08885	COG5577	PFAM Coat F domain
GVI46_RS08900	COG0784	Response regulator, receiver
GVI46_RS08900	COG2205	protein histidine kinase activity
GVI46_RS08920	COG0673	inositol 2-dehydrogenase activity
GVI46_RS08925	COG0673	inositol 2-dehydrogenase activity
GVI46_RS08930	COG1082	Xylose isomerase domain protein TIM barrel
GVI46_RS08935	COG2814	Major facilitator Superfamily
GVI46_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS08960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS08975	COG0384	phenazine biosynthesis protein PhzF
GVI46_RS08980	COG1694	Mazg nucleotide pyrophosphohydrolase
GVI46_RS08990	COG2226	methyltransferase
GVI46_RS09000	COG0789	Transcriptional regulator
GVI46_RS09005	COG1278	Cold shock
GVI46_RS09060	COG1113	amino acid transport
GVI46_RS09070	COG2207	Transcriptional regulator
GVI46_RS09080	COG2376	Dihydroxyacetone kinase
GVI46_RS09105	COG3545	Serine hydrolase
GVI46_RS09110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GVI46_RS09120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GVI46_RS09135	COG1278	Cold shock
GVI46_RS09145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS09150	COG0697	spore germination
GVI46_RS09165	COG2226	methyltransferase
GVI46_RS09175	COG1335	isochorismatase
GVI46_RS09180	COG0138	bifunctional purine biosynthesis protein purh
GVI46_RS09185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS09190	COG1114	Component of the transport system for branched-chain amino acids
GVI46_RS09200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GVI46_RS09210	COG4282	regulation of fungal-type cell wall biogenesis
GVI46_RS09225	COG1017	nitric oxide dioxygenase activity
GVI46_RS09225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GVI46_RS09235	COG3848	Pyruvate phosphate dikinase
GVI46_RS09235	COG0574	Belongs to the PEP-utilizing enzyme family
GVI46_RS09240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GVI46_RS09250	COG0601	transmembrane transport
GVI46_RS09260	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS09265	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS09270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GVI46_RS09280	COG0477	Major facilitator Superfamily
GVI46_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS09335	COG0517	IMP dehydrogenase activity
GVI46_RS09355	COG1309	transcriptional regulator
GVI46_RS09370	COG1070	Carbohydrate kinase
GVI46_RS09375	COG2814	Major facilitator Superfamily
GVI46_RS09375	COG0477	Major facilitator Superfamily
GVI46_RS09385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GVI46_RS09390	COG1845	cytochrome c oxidase, subunit III
GVI46_RS09400	COG0589	response to stress
GVI46_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS09410	COG1612	heme a metabolic process
GVI46_RS09415	COG2072	flavoprotein involved in K transport
GVI46_RS09425	COG2252	PERMEase
GVI46_RS09430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GVI46_RS09435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GVI46_RS09440	COG0022	dehydrogenase e1 component
GVI46_RS09445	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVI46_RS09450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVI46_RS09455	COG3284	Transcriptional regulator
GVI46_RS09460	COG1063	alcohol dehydrogenase
GVI46_RS09475	COG1846	Transcriptional regulator
GVI46_RS09485	COG2721	sulfolactate sulfo-lyase activity
GVI46_RS09495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GVI46_RS09500	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS09505	COG2271	Major facilitator Superfamily
GVI46_RS09510	COG4948	Mandelate Racemase Muconate Lactonizing
GVI46_RS09515	COG2186	Transcriptional regulator
GVI46_RS09535	COG0628	permease
GVI46_RS09540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVI46_RS09550	COG2211	Major facilitator Superfamily
GVI46_RS09570	COG0589	response to stress
GVI46_RS09575	COG5002	protein histidine kinase activity
GVI46_RS09585	COG1937	Protein conserved in bacteria
GVI46_RS09590	COG2608	mercury ion transmembrane transporter activity
GVI46_RS09595	COG2217	Heavy metal translocating P-type atpase
GVI46_RS09605	COG1388	LysM domain
GVI46_RS09610	COG2271	Major facilitator Superfamily
GVI46_RS09640	COG0640	Transcriptional regulator
GVI46_RS09645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GVI46_RS09650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GVI46_RS09650	COG0551	DNA topoisomerase type I activity
GVI46_RS09655	COG5444	nuclease activity
GVI46_RS09675	COG2050	protein possibly involved in aromatic compounds catabolism
GVI46_RS09680	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GVI46_RS09685	COG2323	membrane
GVI46_RS09700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GVI46_RS09705	COG1802	Transcriptional regulator
GVI46_RS09710	COG0473	3-isopropylmalate dehydrogenase activity
GVI46_RS09715	COG2814	Major facilitator Superfamily
GVI46_RS09720	COG1733	regulation of RNA biosynthetic process
GVI46_RS09725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GVI46_RS09725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GVI46_RS09730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVI46_RS09730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVI46_RS09755	COG5566	PFAM Mor transcription activator
GVI46_RS09770	COG0561	phosphatase activity
GVI46_RS09775	COG1876	peptidase activity
GVI46_RS09780	COG0726	polysaccharide deacetylase
GVI46_RS09820	COG0582	viral genome integration into host DNA
GVI46_RS09875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GVI46_RS09915	COG1484	DNA-dependent DNA replication
GVI46_RS09990	COG3677	Transposase
GVI46_RS10020	COG5484	DNA packaging
GVI46_RS10020	COG3728	DNA packaging
GVI46_RS10110	COG3953	SLT domain
GVI46_RS10110	COG5280	Phage tail tape measure protein TP901
GVI46_RS10220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GVI46_RS10235	COG0386	Belongs to the glutathione peroxidase family
GVI46_RS10240	COG1418	mRNA catabolic process
GVI46_RS10245	COG0488	(ABC) transporter
GVI46_RS10250	COG1413	lyase activity
GVI46_RS10255	COG0726	polysaccharide deacetylase
GVI46_RS10265	COG2136	Putative SAM-dependent methyltransferase
GVI46_RS10265	COG2521	methyltransferase
GVI46_RS10275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS10280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GVI46_RS10290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GVI46_RS10295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GVI46_RS10305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GVI46_RS10310	COG0406	alpha-ribazole phosphatase activity
GVI46_RS10320	COG2096	Adenosyltransferase
GVI46_RS10325	COG2962	Rard protein
GVI46_RS10335	COG0523	cobalamin synthesis protein
GVI46_RS10340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GVI46_RS10345	COG0322	excinuclease ABC activity
GVI46_RS10355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GVI46_RS10360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GVI46_RS10365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GVI46_RS10375	COG3011	Protein conserved in bacteria
GVI46_RS10380	COG1595	DNA-templated transcription, initiation
GVI46_RS10400	COG2002	toxin-antitoxin pair type II binding
GVI46_RS10405	COG0534	Mate efflux family protein
GVI46_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS10435	COG1368	sulfuric ester hydrolase activity
GVI46_RS10445	COG3853	Toxic anion resistance protein (TelA)
GVI46_RS10460	COG0726	polysaccharide deacetylase
GVI46_RS10470	COG2234	aminopeptidase activity
GVI46_RS10475	COG5002	protein histidine kinase activity
GVI46_RS10485	COG1823	symporter activity
GVI46_RS10490	COG1523	belongs to the glycosyl hydrolase 13 family
GVI46_RS10495	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS10500	COG2124	cytochrome p450
GVI46_RS10505	COG2112	serine threonine protein kinase
GVI46_RS10515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GVI46_RS10520	COG1360	Flagellar Motor Protein
GVI46_RS10535	COG3361	conserved protein (COG2071)
GVI46_RS10540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVI46_RS10545	COG1757	Na H antiporter
GVI46_RS10555	COG0833	amino acid
GVI46_RS10560	COG3594	Acyltransferase
GVI46_RS10565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVI46_RS10570	COG0745	RESPONSE REGULATOR receiver
GVI46_RS10575	COG5002	protein histidine kinase activity
GVI46_RS10580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GVI46_RS10585	COG3104	oligopeptide transport
GVI46_RS10595	COG0281	malic enzyme
GVI46_RS10600	COG3493	citrate carrier protein
GVI46_RS10605	COG0561	phosphatase activity
GVI46_RS10610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS10625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GVI46_RS10630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS10635	COG0765	amino acid transport
GVI46_RS10640	COG0765	amino acid transport
GVI46_RS10645	COG1126	abc transporter atp-binding protein
GVI46_RS10650	COG0196	riboflavin kinase activity
GVI46_RS10655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS10665	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS10705	COG1611	Belongs to the LOG family
GVI46_RS10710	COG0281	malic enzyme
GVI46_RS10715	COG3402	PFAM membrane-flanked domain
GVI46_RS10720	COG3428	Bacterial PH domain
GVI46_RS10735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS10740	COG0109	protoheme IX farnesyltransferase activity
GVI46_RS10745	COG4195	phage-related replication protein
GVI46_RS10755	COG0789	Transcriptional regulator
GVI46_RS10790	COG0583	DNA-binding transcription factor activity
GVI46_RS10795	COG0070	glutamate synthase
GVI46_RS10795	COG0067	glutamate synthase
GVI46_RS10795	COG0069	glutamate synthase activity
GVI46_RS10800	COG0493	'glutamate synthase
GVI46_RS10820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GVI46_RS10835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS10845	COG1846	Transcriptional regulator
GVI46_RS10850	COG1380	Effector of murein hydrolase LrgA
GVI46_RS10855	COG1346	cytolysis
GVI46_RS10860	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS10875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GVI46_RS10880	COG0463	Glycosyl transferase, family 2
GVI46_RS10890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVI46_RS10895	COG0745	RESPONSE REGULATOR receiver
GVI46_RS10905	COG5583	Uncharacterized small protein (DUF2292)
GVI46_RS10915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GVI46_RS10925	COG4208	sulfate ABC transporter
GVI46_RS10940	COG0745	RESPONSE REGULATOR receiver
GVI46_RS10965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS10975	COG1349	DNA-binding transcription factor activity
GVI46_RS10980	COG1105	Belongs to the carbohydrate kinase PfkB family
GVI46_RS10985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GVI46_RS10985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS10985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GVI46_RS10990	COG0527	aspartate kinase activity
GVI46_RS11000	COG2032	superoxide dismutase activity
GVI46_RS11005	COG1233	COG1233 Phytoene dehydrogenase and related
GVI46_RS11015	COG0300	oxidoreductase activity
GVI46_RS11020	COG0640	Transcriptional regulator
GVI46_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS11030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GVI46_RS11045	COG0733	neurotransmitter:sodium symporter activity
GVI46_RS11055	COG3773	Cell wall hydrolase
GVI46_RS11075	COG0673	inositol 2-dehydrogenase activity
GVI46_RS11080	COG1082	Xylose isomerase domain protein TIM barrel
GVI46_RS11085	COG2094	Belongs to the DNA glycosylase MPG family
GVI46_RS11090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GVI46_RS11100	COG0454	-acetyltransferase
GVI46_RS11110	COG2814	Major facilitator Superfamily
GVI46_RS11125	COG3871	stress protein (general stress protein 26)
GVI46_RS11150	COG1595	DNA-templated transcription, initiation
GVI46_RS11160	COG0714	Associated with various cellular activities
GVI46_RS11165	COG4548	von Willebrand factor, type A
GVI46_RS11170	COG0697	spore germination
GVI46_RS11180	COG2207	Transcriptional regulator
GVI46_RS11185	COG1994	Peptidase M50
GVI46_RS11190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS11195	COG1119	ATPase activity
GVI46_RS11210	COG1657	PFAM Prenyltransferase squalene oxidase
GVI46_RS11220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GVI46_RS11220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GVI46_RS11230	COG0384	phenazine biosynthesis protein PhzF
GVI46_RS11245	COG1378	Sugar-specific transcriptional regulator TrmB
GVI46_RS11250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GVI46_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS11275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS11280	COG1279	arginine transmembrane transporter activity
GVI46_RS11310	COG1396	sequence-specific DNA binding
GVI46_RS11325	COG0494	nUDIX hydrolase
GVI46_RS11330	COG1335	isochorismatase
GVI46_RS11335	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GVI46_RS11340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GVI46_RS11345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GVI46_RS11350	COG1098	S1 RNA binding domain
GVI46_RS11355	COG1404	Belongs to the peptidase S8 family
GVI46_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS11365	COG1254	Belongs to the acylphosphatase family
GVI46_RS11370	COG2223	nitrite transmembrane transporter activity
GVI46_RS11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS11385	COG2207	Transcriptional regulator
GVI46_RS11385	COG0662	Cupin 2, conserved barrel domain protein
GVI46_RS11390	COG0697	spore germination
GVI46_RS11395	COG0488	(ABC) transporter
GVI46_RS11400	COG0697	spore germination
GVI46_RS11405	COG0531	amino acid
GVI46_RS11420	COG1131	(ABC) transporter
GVI46_RS11425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GVI46_RS11430	COG1757	Na H antiporter
GVI46_RS11435	COG1609	Transcriptional regulator
GVI46_RS11445	COG1533	DNA photolyase activity
GVI46_RS11465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GVI46_RS11465	COG0551	DNA topoisomerase type I activity
GVI46_RS11475	COG0446	pyridine nucleotide-disulphide oxidoreductase
GVI46_RS11500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS11520	COG1757	Na H antiporter
GVI46_RS11525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GVI46_RS11535	COG0697	spore germination
GVI46_RS11545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS11555	COG2720	vancomycin resistance protein
GVI46_RS11595	COG0514	ATP-dependent DNA helicase (RecQ)
GVI46_RS11625	COG1575	Belongs to the MenA family. Type 1 subfamily
GVI46_RS11630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GVI46_RS11645	COG2814	Major facilitator Superfamily
GVI46_RS11650	COG0583	DNA-binding transcription factor activity
GVI46_RS11655	COG1725	Transcriptional regulator
GVI46_RS11660	COG1131	(ABC) transporter
GVI46_RS11670	COG1595	DNA-templated transcription, initiation
GVI46_RS11685	COG1764	response to oxidative stress
GVI46_RS11690	COG1846	Transcriptional regulator
GVI46_RS11705	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GVI46_RS11715	COG1388	LysM domain
GVI46_RS11715	COG3584	3D domain protein
GVI46_RS11735	COG5002	protein histidine kinase activity
GVI46_RS11740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GVI46_RS11745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GVI46_RS11750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GVI46_RS11765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GVI46_RS11780	COG2409	Drug exporters of the RND superfamily
GVI46_RS11785	COG1834	amidinotransferase
GVI46_RS11795	COG1295	ribonuclease BN
GVI46_RS11870	COG0110	maltose O-acetyltransferase activity
GVI46_RS11875	COG0346	lactoylglutathione lyase activity
GVI46_RS11885	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS11895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GVI46_RS11905	COG2176	DNA-directed DNA polymerase activity
GVI46_RS11920	COG0114	fumarate hydratase activity
GVI46_RS11930	COG3409	Peptidoglycan-binding domain 1 protein
GVI46_RS11930	COG3757	hydrolase, family 25
GVI46_RS11940	COG5002	protein histidine kinase activity
GVI46_RS11980	COG0778	Nitroreductase
GVI46_RS11990	COG0300	oxidoreductase activity
GVI46_RS12000	COG2610	gluconate transmembrane transporter activity
GVI46_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS12010	COG2195	Cleaves the N-terminal amino acid of tripeptides
GVI46_RS12040	COG0583	DNA-binding transcription factor activity
GVI46_RS12050	COG1301	dicarboxylic acid transport
GVI46_RS12055	COG0019	diaminopimelate decarboxylase activity
GVI46_RS12065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVI46_RS12075	COG4191	Histidine kinase
GVI46_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS12095	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS12105	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVI46_RS12110	COG1024	Enoyl-CoA hydratase
GVI46_RS12125	COG2045	Belongs to the ComB family
GVI46_RS12130	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS12140	COG1024	Enoyl-CoA hydratase
GVI46_RS12155	COG1141	Ferredoxin
GVI46_RS12165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GVI46_RS12175	COG0183	Belongs to the thiolase family
GVI46_RS12180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GVI46_RS12205	COG1509	lysine 2,3-aminomutase activity
GVI46_RS12215	COG0833	amino acid
GVI46_RS12220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS12235	COG1979	alcohol dehydrogenase
GVI46_RS12240	COG0738	Major facilitator superfamily
GVI46_RS12245	COG1181	Belongs to the D-alanine--D-alanine ligase family
GVI46_RS12265	COG3977	Valine--pyruvate aminotransferase
GVI46_RS12270	COG3773	Cell wall hydrolase
GVI46_RS12295	COG0531	amino acid
GVI46_RS12300	COG2814	Major facilitator Superfamily
GVI46_RS12305	COG1846	Transcriptional regulator
GVI46_RS12310	COG2409	Drug exporters of the RND superfamily
GVI46_RS12310	COG1033	growth of symbiont in host cell
GVI46_RS12315	COG3842	ATPase activity
GVI46_RS12320	COG2222	sugar isomerase
GVI46_RS12325	COG1653	transport
GVI46_RS12330	COG1175	transmembrane transport
GVI46_RS12335	COG0395	ABC-type sugar transport system, permease component
GVI46_RS12340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS12345	COG2188	Transcriptional regulator
GVI46_RS12350	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS12350	COG2202	Pas domain
GVI46_RS12355	COG3832	glyoxalase III activity
GVI46_RS12360	COG0640	Transcriptional regulator
GVI46_RS12370	COG2267	carboxylic ester hydrolase activity
GVI46_RS12380	COG3386	PFAM SMP-30 Gluconolaconase
GVI46_RS12390	COG2368	4-hydroxyphenylacetate
GVI46_RS12395	COG3739	integral membrane protein
GVI46_RS12405	COG0326	Molecular chaperone. Has ATPase activity
GVI46_RS12410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GVI46_RS12425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GVI46_RS12440	COG0697	spore germination
GVI46_RS12445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS12460	COG4572	Cation transport regulator
GVI46_RS12465	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GVI46_RS12470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GVI46_RS12485	COG3011	Protein conserved in bacteria
GVI46_RS12490	COG1136	(ABC) transporter
GVI46_RS12550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GVI46_RS12565	COG0494	nUDIX hydrolase
GVI46_RS12570	COG0702	epimerase
GVI46_RS12575	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS12580	COG1846	Transcriptional regulator
GVI46_RS12585	COG2720	vancomycin resistance protein
GVI46_RS12590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GVI46_RS12615	COG0076	glutamate decarboxylase activity
GVI46_RS12645	COG2116	formate transmembrane transporter activity
GVI46_RS12650	COG5609	conserved protein (DUF2294)
GVI46_RS12665	COG2271	Major facilitator Superfamily
GVI46_RS12670	COG0277	FAD linked oxidase domain protein
GVI46_RS12680	COG0840	transmembrane signaling receptor activity
GVI46_RS12690	COG0622	Phosphoesterase
GVI46_RS12700	COG1408	metallophosphoesterase
GVI46_RS12705	COG3663	DNA glycosylase
GVI46_RS12710	COG0791	NLP P60 protein
GVI46_RS12710	COG3883	PFAM NLP P60 protein
GVI46_RS12715	COG1587	Uroporphyrinogen-III synthase
GVI46_RS12720	COG1414	Transcriptional regulator
GVI46_RS12725	COG0439	Biotin carboxylase
GVI46_RS12730	COG0511	ligase activity, forming carbon-carbon bonds
GVI46_RS12735	COG1984	allophanate hydrolase subunit 2
GVI46_RS12740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GVI46_RS12745	COG4336	lyase activity
GVI46_RS12750	COG1914	H( )-stimulated, divalent metal cation uptake system
GVI46_RS12755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GVI46_RS12770	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS12775	COG1268	BioY protein
GVI46_RS12780	COG0183	Belongs to the thiolase family
GVI46_RS12800	COG0431	NADPH-dependent FMN reductase
GVI46_RS12805	COG2197	response regulator
GVI46_RS12810	COG4585	Histidine kinase
GVI46_RS12810	COG2203	Gaf domain
GVI46_RS12830	COG0697	spore germination
GVI46_RS12840	COG2153	protein acetylation
GVI46_RS12845	COG0129	dihydroxy-acid dehydratase activity
GVI46_RS12850	COG2267	carboxylic ester hydrolase activity
GVI46_RS12855	COG1227	inorganic diphosphatase activity
GVI46_RS12875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GVI46_RS12885	COG0204	Acyl-transferase
GVI46_RS12890	COG2233	PERMEase
GVI46_RS12895	COG3195	allantoin biosynthetic process
GVI46_RS12895	COG3648	Uricase
GVI46_RS12920	COG1914	H( )-stimulated, divalent metal cation uptake system
GVI46_RS12940	COG1846	Transcriptional regulator
GVI46_RS12950	COG4974	Belongs to the 'phage' integrase family
GVI46_RS12970	COG0531	amino acid
GVI46_RS12975	COG4302	ethanolamine ammonia-lyase activity
GVI46_RS12980	COG4303	Ethanolamine ammonia lyase large subunit
GVI46_RS12985	COG4819	ethanolamine utilization protein
GVI46_RS12995	COG0833	amino acid
GVI46_RS13005	COG1247	-acetyltransferase
GVI46_RS13010	COG1335	isochorismatase
GVI46_RS13020	COG3403	YqcI/YcgG family
GVI46_RS13025	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS13030	COG2267	carboxylic ester hydrolase activity
GVI46_RS13035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GVI46_RS13040	COG0187	DNA topoisomerase II activity
GVI46_RS13045	COG1832	CoA-binding protein
GVI46_RS13050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GVI46_RS13055	COG4841	protein insertion into membrane
GVI46_RS13060	COG0824	Thioesterase
GVI46_RS13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS13095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GVI46_RS13115	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GVI46_RS13150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GVI46_RS13155	COG2068	MobA-Related Protein
GVI46_RS13160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GVI46_RS13215	COG1183	phosphatidylcholine synthase activity
GVI46_RS13230	COG2814	Major facilitator Superfamily
GVI46_RS13235	COG1683	Conserved Protein
GVI46_RS13240	COG1302	Protein conserved in bacteria
GVI46_RS13255	COG1295	ribonuclease BN
GVI46_RS13265	COG1115	amino acid carrier protein
GVI46_RS13270	COG2814	Major facilitator Superfamily
GVI46_RS13280	COG2814	Major facilitator Superfamily
GVI46_RS13285	COG0789	Transcriptional regulator
GVI46_RS13295	COG0288	reversible hydration of carbon dioxide
GVI46_RS13300	COG0659	secondary active sulfate transmembrane transporter activity
GVI46_RS13305	COG0745	RESPONSE REGULATOR receiver
GVI46_RS13310	COG5002	protein histidine kinase activity
GVI46_RS13320	COG0477	Major facilitator Superfamily
GVI46_RS13325	COG4282	regulation of fungal-type cell wall biogenesis
GVI46_RS13330	COG0531	amino acid
GVI46_RS13340	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS13345	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GVI46_RS13415	COG1363	Peptidase, m42
GVI46_RS13425	COG1114	Component of the transport system for branched-chain amino acids
GVI46_RS13445	COG0004	ammonium transporteR
GVI46_RS13460	COG1252	NADH dehydrogenase
GVI46_RS13465	COG0679	Auxin Efflux Carrier
GVI46_RS13470	COG0281	malic enzyme
GVI46_RS13475	COG1473	amidohydrolase
GVI46_RS13480	COG2271	Major facilitator Superfamily
GVI46_RS13500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GVI46_RS13505	COG0163	prenyltransferase activity
GVI46_RS13510	COG0583	DNA-binding transcription factor activity
GVI46_RS13515	COG0679	Auxin Efflux Carrier
GVI46_RS13535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS13540	COG0247	lactate metabolic process
GVI46_RS13545	COG0277	FAD linked oxidase domain protein
GVI46_RS13550	COG3835	regulator
GVI46_RS13555	COG0693	protein deglycase activity
GVI46_RS13565	COG2610	gluconate transmembrane transporter activity
GVI46_RS13585	COG1131	(ABC) transporter
GVI46_RS13595	COG2197	response regulator
GVI46_RS13630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS13640	COG0586	Pfam SNARE associated Golgi protein
GVI46_RS13645	COG1515	deoxyribonuclease V activity
GVI46_RS13650	COG0584	glycerophosphoryl diester phosphodiesterase
GVI46_RS13655	COG3153	acetyltransferase
GVI46_RS13655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS13665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS13670	COG0531	amino acid
GVI46_RS13725	COG5444	nuclease activity
GVI46_RS13740	COG0534	Mate efflux family protein
GVI46_RS13745	COG1566	PFAM secretion protein HlyD family protein
GVI46_RS13755	COG1846	Transcriptional regulator
GVI46_RS13760	COG0708	Exodeoxyribonuclease III
GVI46_RS13775	COG0673	inositol 2-dehydrogenase activity
GVI46_RS13780	COG1349	DNA-binding transcription factor activity
GVI46_RS13785	COG3853	Toxic anion resistance protein (TelA)
GVI46_RS13795	COG2310	stress, protein
GVI46_RS13800	COG2310	stress, protein
GVI46_RS13805	COG2310	stress, protein
GVI46_RS13810	COG0737	Belongs to the 5'-nucleotidase family
GVI46_RS13825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GVI46_RS13830	COG1131	(ABC) transporter
GVI46_RS13840	COG2084	Dehydrogenase
GVI46_RS13845	COG1278	Cold shock
GVI46_RS13850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS13855	COG0028	Belongs to the TPP enzyme family
GVI46_RS13860	COG1278	Cold shock
GVI46_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS13900	COG0427	acetyl-CoA hydrolase
GVI46_RS13905	COG3279	Response regulator of the LytR AlgR family
GVI46_RS13910	COG2323	membrane
GVI46_RS13915	COG2814	Major facilitator Superfamily
GVI46_RS13920	COG3584	3D domain protein
GVI46_RS13920	COG1388	LysM domain
GVI46_RS13925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GVI46_RS13950	COG3340	Belongs to the peptidase S51 family
GVI46_RS13975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GVI46_RS14005	COG2318	DinB family
GVI46_RS14015	COG0579	oxidoreductase
GVI46_RS14040	COG1486	melibiose metabolic process
GVI46_RS14070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVI46_RS14090	COG1929	Belongs to the glycerate kinase type-1 family
GVI46_RS14095	COG2610	gluconate transmembrane transporter activity
GVI46_RS14100	COG3835	regulator
GVI46_RS14105	COG1454	alcohol dehydrogenase
GVI46_RS14110	COG3152	Membrane
GVI46_RS14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS14140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS14145	COG3152	Membrane
GVI46_RS14165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GVI46_RS14170	COG0295	cytidine deaminase activity
GVI46_RS14175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GVI46_RS14190	COG2390	Transcriptional regulator
GVI46_RS14220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GVI46_RS14230	COG1695	Transcriptional regulator
GVI46_RS14235	COG0501	Belongs to the peptidase M48B family
GVI46_RS14240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS14245	COG1742	UPF0060 membrane protein
GVI46_RS14250	COG2182	Extracellular solute-binding protein
GVI46_RS14270	COG2031	fatty acid transporter
GVI46_RS14295	COG2391	methyltransferase activity
GVI46_RS14310	COG1979	alcohol dehydrogenase
GVI46_RS14315	COG0583	DNA-binding transcription factor activity
GVI46_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS14365	COG1063	alcohol dehydrogenase
GVI46_RS14390	COG0025	NhaP-type Na H and K H
GVI46_RS14395	COG1253	flavin adenine dinucleotide binding
GVI46_RS14405	COG4325	translation initiation factor activity
GVI46_RS14420	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS14430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GVI46_RS14435	COG0601	transmembrane transport
GVI46_RS14440	COG0747	negative chemotaxis
GVI46_RS14470	COG1525	nuclease
GVI46_RS14480	COG0579	oxidoreductase
GVI46_RS14485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GVI46_RS14490	COG0561	phosphatase activity
GVI46_RS14505	COG0668	transmembrane transport
GVI46_RS14535	COG2309	aminopeptidase activity
GVI46_RS14540	COG1414	Transcriptional regulator
GVI46_RS14545	COG0179	Fumarylacetoacetate (FAA) hydrolase
GVI46_RS14550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GVI46_RS14555	COG0277	FAD linked oxidase domain protein
GVI46_RS14560	COG0247	lactate metabolic process
GVI46_RS14565	COG0277	FAD linked oxidase domain protein
GVI46_RS14570	COG1620	l-lactate permease
GVI46_RS14595	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GVI46_RS14600	COG1131	(ABC) transporter
GVI46_RS14620	COG1595	DNA-templated transcription, initiation
GVI46_RS14640	COG4682	membrane
GVI46_RS14655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS14660	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS14665	COG0598	Magnesium transport protein CorA
GVI46_RS14680	COG2323	membrane
GVI46_RS14685	COG1876	peptidase activity
GVI46_RS14700	COG5002	protein histidine kinase activity
GVI46_RS14705	COG0745	RESPONSE REGULATOR receiver
GVI46_RS14725	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVI46_RS14740	COG2814	Major facilitator Superfamily
GVI46_RS14745	COG1764	response to oxidative stress
GVI46_RS14755	COG2311	Membrane
GVI46_RS14805	COG0559	Belongs to the binding-protein-dependent transport system permease family
GVI46_RS14815	COG0347	Belongs to the P(II) protein family
GVI46_RS14820	COG0004	ammonium transporteR
GVI46_RS14825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GVI46_RS14840	COG0596	Alpha beta hydrolase
GVI46_RS14860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GVI46_RS14860	COG0456	acetyltransferase
GVI46_RS14865	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS14905	COG4604	ABC transporter, ATP-binding protein
GVI46_RS14910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS14915	COG1492	cobalamin metabolic process
GVI46_RS14925	COG0531	amino acid
GVI46_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS14940	COG2404	hydrolase activity, acting on ester bonds
GVI46_RS14945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GVI46_RS14955	COG1609	Transcriptional regulator
GVI46_RS14965	COG2271	Major facilitator Superfamily
GVI46_RS14970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS14985	COG1233	COG1233 Phytoene dehydrogenase and related
GVI46_RS14990	COG0463	Glycosyl transferase, family 2
GVI46_RS15045	COG0831	urea catabolic process
GVI46_RS15050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GVI46_RS15055	COG0791	NLP P60 protein
GVI46_RS15055	COG1388	LysM domain
GVI46_RS15060	COG1388	LysM domain
GVI46_RS15060	COG3584	3D domain protein
GVI46_RS15065	COG0778	Nitroreductase
GVI46_RS15070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GVI46_RS15075	COG0586	Pfam SNARE associated Golgi protein
GVI46_RS15085	COG0400	carboxylic ester hydrolase activity
GVI46_RS15090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVI46_RS15095	COG2244	polysaccharide biosynthetic process
GVI46_RS15100	COG0697	spore germination
GVI46_RS15105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS15125	COG1132	(ABC) transporter
GVI46_RS15150	COG4195	phage-related replication protein
GVI46_RS15160	COG0783	Belongs to the Dps family
GVI46_RS15170	COG5577	PFAM Coat F domain
GVI46_RS15175	COG1253	flavin adenine dinucleotide binding
GVI46_RS15190	COG0516	GMP reductase activity
GVI46_RS15190	COG0517	IMP dehydrogenase activity
GVI46_RS15200	COG0723	plastoquinol--plastocyanin reductase activity
GVI46_RS15200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVI46_RS15215	COG0287	Prephenate dehydrogenase
GVI46_RS15225	COG1605	Chorismate mutase
GVI46_RS15225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GVI46_RS15235	COG2059	Chromate
GVI46_RS15240	COG2059	Chromate
GVI46_RS15250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GVI46_RS15255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVI46_RS15260	COG2508	Transcriptional regulator
GVI46_RS15265	COG0011	TIGRFAM Protein of
GVI46_RS15270	COG1388	LysM domain
GVI46_RS15270	COG0791	NLP P60 protein
GVI46_RS15275	COG0753	catalase activity
GVI46_RS15285	COG0733	neurotransmitter:sodium symporter activity
GVI46_RS15325	COG0730	response to heat
GVI46_RS15330	COG1902	pentaerythritol trinitrate reductase activity
GVI46_RS15345	COG2205	protein histidine kinase activity
GVI46_RS15385	COG0640	Transcriptional regulator
GVI46_RS15395	COG0778	Nitroreductase
GVI46_RS15410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GVI46_RS15415	COG3103	Sh3 type 3 domain protein
GVI46_RS15415	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS15415	COG4991	sh3 domain protein
GVI46_RS15420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GVI46_RS15425	COG2002	toxin-antitoxin pair type II binding
GVI46_RS15430	COG2318	DinB family
GVI46_RS15435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVI46_RS15450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GVI46_RS15455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS15470	COG2211	Major facilitator Superfamily
GVI46_RS15475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS15480	COG1597	lipid kinase activity
GVI46_RS15490	COG0372	Belongs to the citrate synthase family
GVI46_RS15495	COG0583	DNA-binding transcription factor activity
GVI46_RS15500	COG0697	spore germination
GVI46_RS15505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS15525	COG2202	Pas domain
GVI46_RS15525	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS15530	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS15560	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS15565	COG2261	transglycosylase associated protein
GVI46_RS15575	COG0740	serine-type endopeptidase activity
GVI46_RS15590	COG1027	Aspartate ammonia-lyase
GVI46_RS15595	COG0252	asparaginase activity
GVI46_RS15600	COG1396	sequence-specific DNA binding
GVI46_RS15615	COG0640	Transcriptional regulator
GVI46_RS15635	COG0531	amino acid
GVI46_RS15640	COG1959	2 iron, 2 sulfur cluster binding
GVI46_RS15660	COG0281	malic enzyme
GVI46_RS15665	COG2746	aminoglycoside 3-N-acetyltransferase activity
GVI46_RS15675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS15690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVI46_RS15695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GVI46_RS15705	COG0477	Major facilitator Superfamily
GVI46_RS15710	COG1846	Transcriptional regulator
GVI46_RS15715	COG0789	Transcriptional regulator
GVI46_RS15720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS15755	COG1819	glycosyl
GVI46_RS15775	COG1902	pentaerythritol trinitrate reductase activity
GVI46_RS15785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GVI46_RS15800	COG2814	Major facilitator Superfamily
GVI46_RS15810	COG1228	amidohydrolase
GVI46_RS15820	COG1316	TRANSCRIPTIONal
GVI46_RS15825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS15845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GVI46_RS15855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GVI46_RS15860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GVI46_RS15915	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS15925	COG0531	amino acid
GVI46_RS15940	COG3764	Sortase (surface protein transpeptidase)
GVI46_RS15945	COG0730	response to heat
GVI46_RS15950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS15955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GVI46_RS15965	COG2130	NADP-dependent
GVI46_RS15985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS16000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GVI46_RS16010	COG0501	Belongs to the peptidase M48B family
GVI46_RS16045	COG0131	Imidazoleglycerol-phosphate dehydratase
GVI46_RS16045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GVI46_RS16060	COG2076	Multidrug Resistance protein
GVI46_RS16065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GVI46_RS16070	COG1278	Cold shock
GVI46_RS16075	COG2323	membrane
GVI46_RS16085	COG2910	NAD(P)H-binding
GVI46_RS16105	COG3546	catalase activity
GVI46_RS16110	COG4607	ABC-type enterochelin transport system periplasmic component
GVI46_RS16115	COG4604	ABC transporter, ATP-binding protein
GVI46_RS16120	COG4605	iron ion homeostasis
GVI46_RS16125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS16130	COG3773	Cell wall hydrolase
GVI46_RS16150	COG1063	alcohol dehydrogenase
GVI46_RS16155	COG3775	system Galactitol-specific IIC component
GVI46_RS16160	COG3414	Phosphotransferase system galactitol-specific IIB component
GVI46_RS16165	COG3414	Phosphotransferase system galactitol-specific IIB component
GVI46_RS16180	COG2249	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS16205	COG1349	DNA-binding transcription factor activity
GVI46_RS16220	COG1193	negative regulation of DNA recombination
GVI46_RS16230	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GVI46_RS16235	COG1396	sequence-specific DNA binding
GVI46_RS16240	COG0861	Integral membrane protein TerC family
GVI46_RS16245	COG1609	Transcriptional regulator
GVI46_RS16250	COG1959	2 iron, 2 sulfur cluster binding
GVI46_RS16310	COG3773	Cell wall hydrolase
GVI46_RS16315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GVI46_RS16340	COG3546	catalase activity
GVI46_RS16360	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS16370	COG4585	Histidine kinase
GVI46_RS16380	COG0584	glycerophosphoryl diester phosphodiesterase
GVI46_RS16395	COG3209	COG3209 Rhs family protein
GVI46_RS16415	COG1819	glycosyl
GVI46_RS16420	COG0456	acetyltransferase
GVI46_RS16435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GVI46_RS16445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GVI46_RS16465	COG0346	lactoylglutathione lyase activity
GVI46_RS16470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GVI46_RS16485	COG1136	(ABC) transporter
GVI46_RS16490	COG0577	efflux transmembrane transporter activity
GVI46_RS16495	COG3850	Histidine kinase
GVI46_RS16495	COG5002	protein histidine kinase activity
GVI46_RS16520	COG5002	protein histidine kinase activity
GVI46_RS16525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS16530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVI46_RS16555	COG4989	oxidoreductase activity
GVI46_RS16565	COG0697	spore germination
GVI46_RS16570	COG1917	Cupin 2, conserved barrel domain protein
GVI46_RS16570	COG2207	Transcriptional regulator
GVI46_RS16645	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GVI46_RS16655	COG1301	dicarboxylic acid transport
GVI46_RS16660	COG2824	Alkylphosphonate utilization operon protein PhnA
GVI46_RS16690	COG0405	Gamma-glutamyltransferase
GVI46_RS16695	COG1073	alpha beta
GVI46_RS16710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GVI46_RS16715	COG4521	taurine ABC transporter
GVI46_RS16720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GVI46_RS16725	COG2175	clavaminate synthase activity
GVI46_RS16730	COG2814	Major facilitator Superfamily
GVI46_RS16750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS16760	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS16765	COG1063	alcohol dehydrogenase
GVI46_RS16770	COG0745	RESPONSE REGULATOR receiver
GVI46_RS16775	COG0642	Histidine kinase
GVI46_RS16780	COG1136	(ABC) transporter
GVI46_RS16785	COG0577	efflux transmembrane transporter activity
GVI46_RS16795	COG0412	Dienelactone hydrolase
GVI46_RS16800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS16815	COG0730	response to heat
GVI46_RS16820	COG0425	Belongs to the sulfur carrier protein TusA family
GVI46_RS16825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS16825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVI46_RS16830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVI46_RS16830	COG0425	Belongs to the sulfur carrier protein TusA family
GVI46_RS16840	COG2210	Belongs to the sulfur carrier protein TusA family
GVI46_RS16845	COG0425	Belongs to the sulfur carrier protein TusA family
GVI46_RS16850	COG1937	Protein conserved in bacteria
GVI46_RS16870	COG0583	DNA-binding transcription factor activity
GVI46_RS16885	COG2188	Transcriptional regulator
GVI46_RS16895	COG2723	6-phospho-beta-galactosidase activity
GVI46_RS16920	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS16935	COG0583	DNA-binding transcription factor activity
GVI46_RS16940	COG2814	Major facilitator Superfamily
GVI46_RS16945	COG0346	lactoylglutathione lyase activity
GVI46_RS16960	COG2723	6-phospho-beta-galactosidase activity
GVI46_RS16970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GVI46_RS16985	COG0778	Nitroreductase
GVI46_RS16990	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS17010	COG1704	LemA family
GVI46_RS17020	COG1733	regulation of RNA biosynthetic process
GVI46_RS17025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GVI46_RS17030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GVI46_RS17035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GVI46_RS17050	COG2304	oxidoreductase activity
GVI46_RS17060	COG0346	lactoylglutathione lyase activity
GVI46_RS17065	COG2808	Putative FMN-binding domain
GVI46_RS17105	COG4807	Protein conserved in bacteria
GVI46_RS17115	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GVI46_RS17120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS17125	COG1278	Cold shock
GVI46_RS17130	COG1278	Cold shock
GVI46_RS17145	COG0747	negative chemotaxis
GVI46_RS17150	COG0601	transmembrane transport
GVI46_RS17155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GVI46_RS17160	COG0444	Belongs to the ABC transporter superfamily
GVI46_RS17165	COG4608	Belongs to the ABC transporter superfamily
GVI46_RS17175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GVI46_RS17180	COG1301	dicarboxylic acid transport
GVI46_RS17195	COG0477	Major facilitator Superfamily
GVI46_RS17240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GVI46_RS17245	COG0659	secondary active sulfate transmembrane transporter activity
GVI46_RS17255	COG2211	Major facilitator Superfamily
GVI46_RS17260	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GVI46_RS17265	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GVI46_RS17270	COG1691	(AIR) carboxylase
GVI46_RS17275	COG1606	tRNA processing
GVI46_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS17290	COG1904	glucuronate isomerase
GVI46_RS17335	COG0561	phosphatase activity
GVI46_RS17345	COG2312	Erythromycin esterase
GVI46_RS17360	COG2329	Antibiotic biosynthesis monooxygenase
GVI46_RS17400	COG3655	Transcriptional regulator
GVI46_RS17410	COG0583	DNA-binding transcription factor activity
GVI46_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS17430	COG1609	Transcriptional regulator
GVI46_RS17435	COG1082	Xylose isomerase domain protein TIM barrel
GVI46_RS17440	COG0673	inositol 2-dehydrogenase activity
GVI46_RS17460	COG3718	enzyme involved in inositol metabolism
GVI46_RS17465	COG3962	Belongs to the TPP enzyme family
GVI46_RS17470	COG1349	DNA-binding transcription factor activity
GVI46_RS17475	COG0191	fructose-bisphosphate aldolase activity
GVI46_RS17480	COG1082	Xylose isomerase domain protein TIM barrel
GVI46_RS17485	COG2814	Major facilitator Superfamily
GVI46_RS17500	COG1064	alcohol dehydrogenase
GVI46_RS17505	COG0789	Transcriptional regulator
GVI46_RS17520	COG0662	Cupin 2, conserved barrel domain protein
GVI46_RS17535	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS17540	COG1278	Cold shock
GVI46_RS17560	COG1876	peptidase activity
GVI46_RS17580	COG0598	Magnesium transport protein CorA
GVI46_RS17585	COG1366	Belongs to the anti-sigma-factor antagonist family
GVI46_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS17625	COG4335	DNA alkylation repair
GVI46_RS17630	COG0454	-acetyltransferase
GVI46_RS17650	COG2814	Major facilitator Superfamily
GVI46_RS17655	COG3848	Pyruvate phosphate dikinase
GVI46_RS17655	COG0574	Belongs to the PEP-utilizing enzyme family
GVI46_RS17660	COG0574	Belongs to the PEP-utilizing enzyme family
GVI46_RS17660	COG3848	Pyruvate phosphate dikinase
GVI46_RS17675	COG2186	Transcriptional regulator
GVI46_RS17695	COG3619	membrane
GVI46_RS17700	COG1349	DNA-binding transcription factor activity
GVI46_RS17705	COG0561	phosphatase activity
GVI46_RS17715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GVI46_RS17740	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS17755	COG3153	acetyltransferase
GVI46_RS17755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVI46_RS17765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GVI46_RS17785	COG2814	Major facilitator Superfamily
GVI46_RS17790	COG2160	L-arabinose isomerase activity
GVI46_RS17805	COG1609	Transcriptional regulator
GVI46_RS17810	COG1078	dGTPase activity
GVI46_RS17830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GVI46_RS17835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GVI46_RS17840	COG1918	ferrous iron import across plasma membrane
GVI46_RS17840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GVI46_RS17865	COG1846	Transcriptional regulator
GVI46_RS17900	COG0697	spore germination
GVI46_RS17905	COG0791	NLP P60 protein
GVI46_RS17905	COG1388	LysM domain
GVI46_RS17910	COG2258	MOSC domain
GVI46_RS17915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GVI46_RS17950	COG4974	Belongs to the 'phage' integrase family
GVI46_RS17990	COG1309	transcriptional regulator
GVI46_RS17995	COG3844	kynureninase activity
GVI46_RS18000	COG1113	amino acid transport
GVI46_RS18005	COG3483	tryptophan 2,3-dioxygenase activity
GVI46_RS18010	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GVI46_RS18015	COG1942	4-Oxalocrotonate Tautomerase
GVI46_RS18045	COG0251	oxidation-reduction process
GVI46_RS18060	COG0431	NADPH-dependent FMN reductase
GVI46_RS18065	COG0196	riboflavin kinase activity
GVI46_RS18070	COG2368	4-hydroxyphenylacetate
GVI46_RS18090	COG0789	Transcriptional regulator
GVI46_RS18125	COG5646	InterPro IPR014922
GVI46_RS18155	COG2814	Major facilitator Superfamily
GVI46_RS18165	COG0583	DNA-binding transcription factor activity
GVI46_RS18175	COG2807	transmembrane transport
GVI46_RS18180	COG0583	DNA-binding transcription factor activity
GVI46_RS18185	COG0583	DNA-binding transcription factor activity
GVI46_RS18195	COG2258	MOSC domain
GVI46_RS18210	COG0477	Major facilitator Superfamily
GVI46_RS18215	COG0583	DNA-binding transcription factor activity
GVI46_RS18220	COG2070	2-Nitropropane dioxygenase
GVI46_RS18225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GVI46_RS18240	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS18250	COG2271	Major facilitator Superfamily
GVI46_RS18255	COG4948	Mandelate Racemase Muconate Lactonizing
GVI46_RS18265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVI46_RS18270	COG1414	Transcriptional regulator
GVI46_RS18275	COG1476	TRANSCRIPTIONal
GVI46_RS18310	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS18325	COG1501	Belongs to the glycosyl hydrolase 31 family
GVI46_RS18335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GVI46_RS18345	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GVI46_RS18355	COG0300	oxidoreductase activity
GVI46_RS18365	COG0596	Alpha beta hydrolase
GVI46_RS18365	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVI46_RS18370	COG1309	transcriptional regulator
GVI46_RS18380	COG1733	regulation of RNA biosynthetic process
GVI46_RS18385	COG2249	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GVI46_RS18395	COG2226	methyltransferase
GVI46_RS18410	COG1942	4-Oxalocrotonate Tautomerase
GVI46_RS18415	COG0583	DNA-binding transcription factor activity
GVI46_RS18420	COG0047	phosphoribosylformylglycinamidine synthase activity
GVI46_RS18425	COG1522	sequence-specific DNA binding
GVI46_RS18435	COG2267	carboxylic ester hydrolase activity
GVI46_RS18445	COG1335	isochorismatase
GVI46_RS18455	COG0346	lactoylglutathione lyase activity
GVI46_RS18460	COG2259	Doxx family
GVI46_RS18465	COG0039	L-malate dehydrogenase activity
GVI46_RS18475	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GVI46_RS18490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GVI46_RS18495	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS18495	COG1454	alcohol dehydrogenase
GVI46_RS18500	COG4816	utilization protein
GVI46_RS18505	COG4302	ethanolamine ammonia-lyase activity
GVI46_RS18510	COG4303	Ethanolamine ammonia lyase large subunit
GVI46_RS18520	COG4917	ethanolamine utilization protein
GVI46_RS18525	COG4810	utilization protein
GVI46_RS18530	COG3192	ethanolamine utilization protein
GVI46_RS18560	COG1309	transcriptional regulator
GVI46_RS18565	COG2076	Multidrug Resistance protein
GVI46_RS18575	COG0477	Major facilitator Superfamily
GVI46_RS18580	COG1609	Transcriptional regulator
GVI46_RS18585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GVI46_RS18605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GVI46_RS18615	COG2851	Citrate transporter
GVI46_RS18625	COG0477	Major facilitator Superfamily
GVI46_RS18635	COG0477	Major facilitator Superfamily
GVI46_RS18640	COG1309	transcriptional regulator
GVI46_RS18660	COG2318	DinB family
GVI46_RS18665	COG0156	8-amino-7-oxononanoate synthase activity
GVI46_RS18670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVI46_RS18690	COG1378	Sugar-specific transcriptional regulator TrmB
GVI46_RS18695	COG0697	spore germination
GVI46_RS18705	COG0583	DNA-binding transcription factor activity
GVI46_RS18740	COG1266	CAAX protease self-immunity
GVI46_RS18760	COG0252	asparaginase activity
GVI46_RS18780	COG1695	Transcriptional regulator
GVI46_RS18785	COG0656	L-ascorbic acid biosynthetic process
GVI46_RS18795	COG0583	DNA-binding transcription factor activity
GVI46_RS18805	COG2814	Major facilitator Superfamily
GVI46_RS18815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GVI46_RS18825	COG0281	malic enzyme
GVI46_RS18830	COG2404	hydrolase activity, acting on ester bonds
GVI46_RS18890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GVI46_RS18955	COG3339	Conserved Protein
GVI46_RS18970	COG2207	Transcriptional regulator
GVI46_RS18970	COG3708	Transcriptional regulator
GVI46_RS18985	COG1357	PFAM Pentapeptide repeats (8 copies)
GVI46_RS18995	COG2249	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS19000	COG1733	regulation of RNA biosynthetic process
GVI46_RS19030	COG0303	'Molybdopterin
GVI46_RS19040	COG0521	Mo-molybdopterin cofactor biosynthetic process
GVI46_RS19045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GVI46_RS19075	COG2244	polysaccharide biosynthetic process
GVI46_RS19095	COG2828	Protein conserved in bacteria
GVI46_RS19100	COG0583	DNA-binding transcription factor activity
GVI46_RS19105	COG2851	Citrate transporter
GVI46_RS19120	COG0670	Belongs to the BI1 family
GVI46_RS19140	COG0791	NLP P60 protein
GVI46_RS19145	COG2814	Major facilitator Superfamily
GVI46_RS19150	COG1846	Transcriptional regulator
GVI46_RS19170	COG1278	Cold shock
GVI46_RS19185	COG1113	amino acid transport
GVI46_RS19190	COG1113	amino acid transport
GVI46_RS19195	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS19200	COG0506	proline dehydrogenase activity
GVI46_RS19205	COG3878	Protein conserved in bacteria
GVI46_RS19220	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS19225	COG5001	Diguanylate cyclase
GVI46_RS19225	COG3300	MHYT domain
GVI46_RS19275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GVI46_RS19280	COG5609	conserved protein (DUF2294)
GVI46_RS19285	COG3223	Belongs to the PsiE family
GVI46_RS19290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GVI46_RS19315	COG0454	-acetyltransferase
GVI46_RS19330	COG0789	Transcriptional regulator
GVI46_RS19335	COG0667	Aldo Keto reductase
GVI46_RS19345	COG0789	Transcriptional regulator
GVI46_RS19370	COG1621	beta-fructofuranosidase activity
GVI46_RS19375	COG4980	gas vesicle protein
GVI46_RS19400	COG1752	Esterase of the alpha-beta hydrolase superfamily
GVI46_RS19405	COG0577	efflux transmembrane transporter activity
GVI46_RS19410	COG1136	(ABC) transporter
GVI46_RS19420	COG0642	Histidine kinase
GVI46_RS19425	COG0745	RESPONSE REGULATOR receiver
GVI46_RS19435	COG1289	transmembrane transporter activity
GVI46_RS19440	COG1937	Protein conserved in bacteria
GVI46_RS19445	COG3209	COG3209 Rhs family protein
GVI46_RS19455	COG3973	AAA domain
GVI46_RS19460	COG1024	Enoyl-CoA hydratase
GVI46_RS19465	COG1733	regulation of RNA biosynthetic process
GVI46_RS19480	COG2124	cytochrome p450
GVI46_RS19485	COG2259	Doxx family
GVI46_RS19490	COG0463	Glycosyl transferase, family 2
GVI46_RS19500	COG0463	Glycosyl transferase, family 2
GVI46_RS19515	COG0791	NLP P60 protein
GVI46_RS19515	COG1388	LysM domain
GVI46_RS19520	COG0840	transmembrane signaling receptor activity
GVI46_RS19525	COG1846	Transcriptional regulator
GVI46_RS19535	COG1595	DNA-templated transcription, initiation
GVI46_RS19540	COG0726	polysaccharide deacetylase
GVI46_RS19560	COG0833	amino acid
GVI46_RS19570	COG0405	Gamma-glutamyltransferase
GVI46_RS19590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GVI46_RS19595	COG0569	domain protein
GVI46_RS19605	COG1522	sequence-specific DNA binding
GVI46_RS19615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVI46_RS19620	COG0745	RESPONSE REGULATOR receiver
GVI46_RS19625	COG2770	Histidine kinase
GVI46_RS19625	COG2205	protein histidine kinase activity
GVI46_RS19630	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GVI46_RS19635	COG1607	acyl-coa hydrolase
GVI46_RS19640	COG1802	Transcriptional regulator
GVI46_RS19645	COG0697	spore germination
GVI46_RS19655	COG0006	proline dipeptidase activity
GVI46_RS19665	COG1316	TRANSCRIPTIONal
GVI46_RS19675	COG2249	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS19680	COG5522	Integral membrane protein (intg_mem_TP0381)
GVI46_RS19685	COG1174	glycine betaine transport
GVI46_RS19690	COG1125	glycine betaine transport
GVI46_RS19690	COG0517	IMP dehydrogenase activity
GVI46_RS19705	COG2814	Major facilitator Superfamily
GVI46_RS19715	COG0395	ABC-type sugar transport system, permease component
GVI46_RS19740	COG2205	protein histidine kinase activity
GVI46_RS19745	COG0730	response to heat
GVI46_RS19750	COG1301	dicarboxylic acid transport
GVI46_RS19785	COG1316	TRANSCRIPTIONal
GVI46_RS19790	COG1368	sulfuric ester hydrolase activity
GVI46_RS19800	COG0697	spore germination
GVI46_RS19805	COG1902	pentaerythritol trinitrate reductase activity
GVI46_RS19820	COG1113	amino acid transport
GVI46_RS19825	COG5505	Protein of unknown function (DUF819)
GVI46_RS19830	COG1309	transcriptional regulator
GVI46_RS19840	COG0583	DNA-binding transcription factor activity
GVI46_RS19845	COG0730	response to heat
GVI46_RS19850	COG1247	-acetyltransferase
GVI46_RS19855	COG2910	NAD(P)H-binding
GVI46_RS19860	COG1285	pathogenesis
GVI46_RS19865	COG2226	methyltransferase
GVI46_RS19870	COG4195	phage-related replication protein
GVI46_RS19875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GVI46_RS19890	COG1113	amino acid transport
GVI46_RS19920	COG0463	Glycosyl transferase, family 2
GVI46_RS19945	COG2514	catechol 2,3-dioxygenase activity
GVI46_RS19965	COG1280	lysine exporter protein (LysE YggA)
GVI46_RS19970	COG1115	amino acid carrier protein
GVI46_RS19980	COG0385	Bile acid
GVI46_RS19985	COG0668	transmembrane transport
GVI46_RS19990	COG2340	Cysteine-rich secretory protein family
GVI46_RS19995	COG1253	flavin adenine dinucleotide binding
GVI46_RS20005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GVI46_RS20010	COG0589	response to stress
GVI46_RS20015	COG0205	6-phosphofructokinase activity
GVI46_RS20020	COG0791	NLP P60 protein
GVI46_RS20020	COG1388	LysM domain
GVI46_RS20030	COG0432	Pfam Uncharacterised protein family UPF0047
GVI46_RS20035	COG0697	spore germination
GVI46_RS20040	COG0814	amino acid
GVI46_RS20065	COG1131	(ABC) transporter
GVI46_RS20080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GVI46_RS20095	COG0584	glycerophosphoryl diester phosphodiesterase
GVI46_RS20105	COG1131	(ABC) transporter
GVI46_RS20130	COG1263	PTS System
GVI46_RS20130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS20135	COG3711	transcriptional antiterminator
GVI46_RS20140	COG2190	(PTS) system
GVI46_RS20145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GVI46_RS20160	COG0772	Belongs to the SEDS family
GVI46_RS20165	COG0659	secondary active sulfate transmembrane transporter activity
GVI46_RS20170	COG0813	purine-nucleoside phosphorylase activity
GVI46_RS20180	COG0671	phosphoesterase, PA-phosphatase related
GVI46_RS20185	COG4326	sporulation control protein
GVI46_RS20190	COG2815	serine threonine protein kinase
GVI46_RS20190	COG0515	serine threonine protein kinase
GVI46_RS20215	COG4479	Belongs to the UPF0346 family
GVI46_RS20225	COG3594	Acyltransferase
GVI46_RS20240	COG1509	lysine 2,3-aminomutase activity
GVI46_RS20245	COG0456	acetyltransferase
GVI46_RS20250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVI46_RS20255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GVI46_RS20260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GVI46_RS20265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GVI46_RS20270	COG1301	dicarboxylic acid transport
GVI46_RS20280	COG4191	Histidine kinase
GVI46_RS20305	COG2755	lipolytic protein G-D-S-L family
GVI46_RS20310	COG1999	signal sequence binding
GVI46_RS20320	COG1307	EDD domain protein, DegV family
GVI46_RS20330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GVI46_RS20340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GVI46_RS20345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GVI46_RS20350	COG0788	formyltetrahydrofolate deformylase activity
GVI46_RS20380	COG0076	glutamate decarboxylase activity
GVI46_RS20400	COG0415	Belongs to the DNA photolyase family
GVI46_RS20405	COG3852	Histidine kinase
GVI46_RS20420	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS20430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GVI46_RS20440	COG4846	Membrane protein involved in cytochrome C biogenesis
GVI46_RS20445	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GVI46_RS20450	COG0785	Cytochrome C biogenesis protein
GVI46_RS20460	COG1132	(ABC) transporter
GVI46_RS20465	COG1132	(ABC) transporter
GVI46_RS20485	COG4224	UPF0291 protein
GVI46_RS20490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GVI46_RS20515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GVI46_RS20520	COG0531	amino acid
GVI46_RS20530	COG0174	glutamine synthetase
GVI46_RS20535	COG0789	Transcriptional regulator
GVI46_RS20540	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GVI46_RS20545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GVI46_RS20550	COG2860	membrane
GVI46_RS20555	COG0464	growth
GVI46_RS20565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GVI46_RS20575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GVI46_RS20580	COG0531	amino acid
GVI46_RS20590	COG4550	Control of competence regulator ComK, YlbF/YmcA
GVI46_RS20595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVI46_RS20600	COG1013	pyruvate-flavodoxin oxidoreductase activity
GVI46_RS20605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GVI46_RS20605	COG0674	pyruvate-flavodoxin oxidoreductase activity
GVI46_RS20620	COG2359	stage V sporulation protein S
GVI46_RS20625	COG1692	metallophosphoesterase
GVI46_RS20635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GVI46_RS20640	COG1546	Belongs to the CinA family
GVI46_RS20640	COG1058	Belongs to the CinA family
GVI46_RS20645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GVI46_RS20650	COG1426	Protein conserved in bacteria
GVI46_RS20665	COG0300	oxidoreductase activity
GVI46_RS20670	COG0612	Peptidase, M16
GVI46_RS20675	COG0612	Peptidase, M16
GVI46_RS20700	COG2188	Transcriptional regulator
GVI46_RS20705	COG1674	ftsk spoiiie
GVI46_RS20705	COG4980	gas vesicle protein
GVI46_RS20715	COG0740	serine-type endopeptidase activity
GVI46_RS20720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GVI46_RS20730	COG0527	aspartate kinase activity
GVI46_RS20735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GVI46_RS20740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GVI46_RS20745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GVI46_RS20750	COG1873	PFAM PRC-barrel domain
GVI46_RS20755	COG0612	Peptidase, M16
GVI46_RS20760	COG0726	polysaccharide deacetylase
GVI46_RS20765	COG1185	polyribonucleotide nucleotidyltransferase activity
GVI46_RS20770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GVI46_RS20775	COG0196	riboflavin kinase activity
GVI46_RS20790	COG1550	Protein conserved in bacteria
GVI46_RS20800	COG1358	cellular component organization or biogenesis
GVI46_RS20805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GVI46_RS20810	COG0195	Participates in both transcription termination and antitermination
GVI46_RS20815	COG0779	Required for maturation of 30S ribosomal subunits
GVI46_RS20820	COG2176	DNA-directed DNA polymerase activity
GVI46_RS20825	COG0442	prolyl-tRNA aminoacylation
GVI46_RS20830	COG0750	zinc metalloprotease
GVI46_RS20840	COG4589	Belongs to the CDS family
GVI46_RS20850	COG0233	cytoplasmic translational termination
GVI46_RS20855	COG0528	UMP kinase activity
GVI46_RS20860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GVI46_RS20875	COG1191	sigma factor activity
GVI46_RS20880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GVI46_RS20885	COG0835	chemotaxis
GVI46_RS20890	COG0643	Histidine kinase
GVI46_RS20890	COG2198	Histidine kinase
GVI46_RS20895	COG2201	protein-glutamate methylesterase activity
GVI46_RS20900	COG0455	bacterial-type flagellum organization
GVI46_RS20905	COG1419	protein localization to endoplasmic reticulum
GVI46_RS20910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GVI46_RS20915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GVI46_RS20920	COG1684	flagellar biosynthetic protein fliR
GVI46_RS20925	COG1987	bacterial-type flagellum assembly
GVI46_RS20930	COG1338	Plays a role in the flagellum-specific transport system
GVI46_RS20935	COG3190	flagellar
GVI46_RS20940	COG2201	protein-glutamate methylesterase activity
GVI46_RS20945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVI46_RS20945	COG1776	CheC inhibitor of MCP methylation
GVI46_RS20950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVI46_RS20960	COG1582	Flagellar protein (FlbD)
GVI46_RS20965	COG4786	Flagellar basal body rod
GVI46_RS20970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GVI46_RS20985	COG2882	bacterial-type flagellum organization
GVI46_RS20990	COG1157	protein secretion by the type III secretion system
GVI46_RS20995	COG1317	bacterial-type flagellum organization
GVI46_RS21000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVI46_RS21005	COG1766	The M ring may be actively involved in energy transduction
GVI46_RS21010	COG1677	Flagellar hook-basal body complex protein FliE
GVI46_RS21015	COG1558	bacterial-type flagellum-dependent cell motility
GVI46_RS21020	COG1815	bacterial-type flagellum-dependent cell motility
GVI46_RS21025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GVI46_RS21030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GVI46_RS21040	COG4974	Belongs to the 'phage' integrase family
GVI46_RS21050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GVI46_RS21055	COG0758	DNA mediated transformation
GVI46_RS21060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GVI46_RS21065	COG0045	succinate-CoA ligase (ADP-forming) activity
GVI46_RS21085	COG0335	large ribosomal subunit rRNA binding
GVI46_RS21095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GVI46_RS21105	COG1837	Belongs to the UPF0109 family
GVI46_RS21110	COG0228	four-way junction DNA binding
GVI46_RS21115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GVI46_RS21125	COG0552	protein localization to endoplasmic reticulum
GVI46_RS21130	COG1196	nuclear chromosome segregation
GVI46_RS21140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GVI46_RS21145	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS21150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GVI46_RS21155	COG0416	fatty acid biosynthetic process
GVI46_RS21160	COG1349	DNA-binding transcription factor activity
GVI46_RS21165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GVI46_RS21170	COG1760	l-serine dehydratase
GVI46_RS21175	COG1760	l-serine dehydratase
GVI46_RS21185	COG1461	Dihydroxyacetone kinase
GVI46_RS21190	COG1302	Protein conserved in bacteria
GVI46_RS21195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GVI46_RS21205	COG1564	THIamine pyrophosphokinase
GVI46_RS21210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GVI46_RS21215	COG1162	GTPase activity
GVI46_RS21220	COG0515	serine threonine protein kinase
GVI46_RS21220	COG2815	serine threonine protein kinase
GVI46_RS21225	COG0631	protein serine/threonine phosphatase activity
GVI46_RS21235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GVI46_RS21235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GVI46_RS21240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GVI46_RS21250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GVI46_RS21255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GVI46_RS21260	COG1758	RNA polymerase activity
GVI46_RS21265	COG0194	GDP metabolic process
GVI46_RS21270	COG2052	Domain of unknown function (DUF370)
GVI46_RS21275	COG1561	YicC-like family, N-terminal region
GVI46_RS21280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GVI46_RS21290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GVI46_RS21320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GVI46_RS21335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GVI46_RS21340	COG0564	pseudouridine synthase activity
GVI46_RS21345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GVI46_RS21360	COG3599	regulation of cell shape
GVI46_RS21365	COG2302	S4 RNA-binding domain
GVI46_RS21370	COG0762	integral membrane protein
GVI46_RS21375	COG1799	cell septum assembly
GVI46_RS21380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GVI46_RS21390	COG1873	PFAM PRC-barrel domain
GVI46_RS21395	COG1191	sigma factor activity
GVI46_RS21400	COG1191	sigma factor activity
GVI46_RS21410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GVI46_RS21415	COG0849	cell division
GVI46_RS21420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GVI46_RS21425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GVI46_RS21430	COG0772	Belongs to the SEDS family
GVI46_RS21435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GVI46_RS21440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GVI46_RS21445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GVI46_RS21450	COG0768	penicillin binding
GVI46_RS21460	COG4839	cell division protein FtsL
GVI46_RS21470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GVI46_RS21480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GVI46_RS21485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GVI46_RS21490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GVI46_RS21495	COG0439	Biotin carboxylase
GVI46_RS21500	COG0454	-acetyltransferase
GVI46_RS21510	COG1024	Enoyl-CoA hydratase
GVI46_RS21515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GVI46_RS21520	COG1399	metal-binding, possibly nucleic acid-binding protein
GVI46_RS21525	COG1323	Belongs to the UPF0348 family
GVI46_RS21530	COG3480	Lon protease (S16) C-terminal proteolytic domain
GVI46_RS21535	COG1752	Esterase of the alpha-beta hydrolase superfamily
GVI46_RS21540	COG3314	Sporulation integral membrane protein YlbJ
GVI46_RS21545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GVI46_RS21550	COG0742	ribosomal rna small subunit methyltransferase
GVI46_RS21560	COG4471	UPF0298 protein
GVI46_RS21570	COG3679	Belongs to the UPF0342 family
GVI46_RS21590	COG4347	Protein of unknown function (DUF1405)
GVI46_RS21600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GVI46_RS21615	COG5582	Belongs to the UPF0302 family
GVI46_RS21620	COG0457	Tetratricopeptide repeat
GVI46_RS21625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GVI46_RS21630	COG0287	Prephenate dehydrogenase
GVI46_RS21635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GVI46_RS21640	COG0159	tryptophan synthase activity
GVI46_RS21650	COG0135	phosphoribosylanthranilate isomerase activity
GVI46_RS21655	COG0134	indole-3-glycerol-phosphate synthase activity
GVI46_RS21660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GVI46_RS21670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GVI46_RS21675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GVI46_RS21680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GVI46_RS21685	COG0105	UTP biosynthetic process
GVI46_RS21690	COG0142	geranyltranstransferase activity
GVI46_RS21695	COG2226	methyltransferase
GVI46_RS21700	COG0142	geranyltranstransferase activity
GVI46_RS21710	COG0302	gtp cyclohydrolase
GVI46_RS21715	COG0776	regulation of translation
GVI46_RS21720	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GVI46_RS21755	COG2271	Major facilitator Superfamily
GVI46_RS21760	COG1304	FMN binding
GVI46_RS21765	COG0539	negative regulation of cytoplasmic translation
GVI46_RS21775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GVI46_RS21790	COG2959	enzyme of heme biosynthesis
GVI46_RS21795	COG3773	Cell wall hydrolase
GVI46_RS21795	COG3409	Peptidoglycan-binding domain 1 protein
GVI46_RS21800	COG2339	peptidase activity
GVI46_RS21805	COG0252	asparaginase activity
GVI46_RS21810	COG0492	ferredoxin-NADP+ reductase activity
GVI46_RS21815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GVI46_RS21820	COG4862	establishment of competence for transformation
GVI46_RS21825	COG0789	Transcriptional regulator
GVI46_RS21830	COG1408	metallophosphoesterase
GVI46_RS21845	COG1266	CAAX protease self-immunity
GVI46_RS21850	COG0514	ATP-dependent DNA helicase (RecQ)
GVI46_RS21860	COG1141	Ferredoxin
GVI46_RS21865	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GVI46_RS21870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GVI46_RS21875	COG0739	heme binding
GVI46_RS21880	COG5002	protein histidine kinase activity
GVI46_RS21885	COG0745	RESPONSE REGULATOR receiver
GVI46_RS21890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GVI46_RS21895	COG1333	cytochrome c biogenesis protein
GVI46_RS21900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS21905	COG1187	pseudouridine synthase activity
GVI46_RS21910	COG0700	Nucleoside recognition
GVI46_RS21915	COG2715	membrane protein required for spore maturation
GVI46_RS21920	COG1686	Belongs to the peptidase S11 family
GVI46_RS21925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GVI46_RS21930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GVI46_RS21940	COG1547	Domain of unknown function (DUF309)
GVI46_RS21950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GVI46_RS21955	COG4086	secreted protein
GVI46_RS21965	COG0697	spore germination
GVI46_RS21980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GVI46_RS22015	COG1686	Belongs to the peptidase S11 family
GVI46_RS22030	COG4974	Belongs to the 'phage' integrase family
GVI46_RS22040	COG0735	belongs to the Fur family
GVI46_RS22045	COG1300	Membrane
GVI46_RS22050	COG0494	nUDIX hydrolase
GVI46_RS22060	COG0667	Aldo Keto reductase
GVI46_RS22070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GVI46_RS22075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GVI46_RS22085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GVI46_RS22090	COG1073	alpha beta
GVI46_RS22105	COG0300	oxidoreductase activity
GVI46_RS22110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS22115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GVI46_RS22120	COG1902	pentaerythritol trinitrate reductase activity
GVI46_RS22130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GVI46_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS22140	COG2508	Transcriptional regulator
GVI46_RS22160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GVI46_RS22160	COG0167	dihydroorotate dehydrogenase activity
GVI46_RS22165	COG0493	'glutamate synthase
GVI46_RS22170	COG2195	Cleaves the N-terminal amino acid of tripeptides
GVI46_RS22175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GVI46_RS22180	COG0346	lactoylglutathione lyase activity
GVI46_RS22190	COG1376	ErfK ybiS ycfS ynhG family protein
GVI46_RS22195	COG4129	membrane
GVI46_RS22200	COG1126	abc transporter atp-binding protein
GVI46_RS22205	COG0765	amino acid transport
GVI46_RS22210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GVI46_RS22220	COG1703	isobutyryl-CoA mutase activity
GVI46_RS22225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GVI46_RS22225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GVI46_RS22235	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVI46_RS22240	COG0022	dehydrogenase e1 component
GVI46_RS22245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GVI46_RS22250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVI46_RS22265	COG0280	phosphate acetyltransferase
GVI46_RS22270	COG3829	transcription factor binding
GVI46_RS22270	COG3290	protein histidine kinase activity
GVI46_RS22280	COG0584	glycerophosphoryl diester phosphodiesterase
GVI46_RS22285	COG3093	addiction module antidote protein HigA
GVI46_RS22290	COG3104	oligopeptide transport
GVI46_RS22295	COG0745	RESPONSE REGULATOR receiver
GVI46_RS22300	COG0750	zinc metalloprotease
GVI46_RS22305	COG0497	DNA recombination
GVI46_RS22315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GVI46_RS22330	COG1722	exodeoxyribonuclease VII activity
GVI46_RS22340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GVI46_RS22345	COG1302	Protein conserved in bacteria
GVI46_RS22350	COG0439	Biotin carboxylase
GVI46_RS22355	COG0511	ligase activity, forming carbon-carbon bonds
GVI46_RS22395	COG3854	ATPases associated with a variety of cellular activities
GVI46_RS22405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GVI46_RS22410	COG0006	proline dipeptidase activity
GVI46_RS22415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GVI46_RS22425	COG3872	metal-dependent enzyme
GVI46_RS22435	COG1752	Esterase of the alpha-beta hydrolase superfamily
GVI46_RS22440	COG1321	iron dependent repressor
GVI46_RS22445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVI46_RS22450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVI46_RS22455	COG0095	Lipoate-protein ligase
GVI46_RS22460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVI46_RS22470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GVI46_RS22475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GVI46_RS22480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GVI46_RS22510	COG4970	Tfp pilus assembly protein FimT
GVI46_RS22515	COG4537	Required for transformation and DNA binding
GVI46_RS22520	COG1459	type II secretion system
GVI46_RS22525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GVI46_RS22530	COG1393	Belongs to the ArsC family
GVI46_RS22540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS22555	COG1940	carbohydrate kinase activity
GVI46_RS22560	COG4483	Protein conserved in bacteria
GVI46_RS22565	COG0705	Rhomboid family
GVI46_RS22565	COG0457	Tetratricopeptide repeat
GVI46_RS22575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GVI46_RS22585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GVI46_RS22600	COG0704	Plays a role in the regulation of phosphate uptake
GVI46_RS22615	COG0477	Major facilitator Superfamily
GVI46_RS22650	COG2839	Protein conserved in bacteria
GVI46_RS22660	COG2814	Major facilitator Superfamily
GVI46_RS22665	COG1388	LysM domain
GVI46_RS22670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GVI46_RS22675	COG4709	membrane
GVI46_RS22680	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GVI46_RS22685	COG0735	belongs to the Fur family
GVI46_RS22690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GVI46_RS22695	COG1121	(ABC) transporter
GVI46_RS22705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GVI46_RS22710	COG0513	Belongs to the DEAD box helicase family
GVI46_RS22720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GVI46_RS22725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GVI46_RS22730	COG2384	SAM-dependent methyltransferase
GVI46_RS22735	COG2010	Cytochrome c
GVI46_RS22740	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS22745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GVI46_RS22750	COG0358	DNA primase activity
GVI46_RS22755	COG1671	Belongs to the UPF0178 family
GVI46_RS22760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GVI46_RS22765	COG0517	IMP dehydrogenase activity
GVI46_RS22780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GVI46_RS22785	COG0295	cytidine deaminase activity
GVI46_RS22790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GVI46_RS22800	COG1480	7TM receptor with intracellular HD hydrolase
GVI46_RS22805	COG1702	phosphate starvation-inducible protein PhoH
GVI46_RS22830	COG1030	water channel activity
GVI46_RS22835	COG1610	YqeY-like protein
GVI46_RS22840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GVI46_RS22845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVI46_RS22850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GVI46_RS22855	COG2264	protein methyltransferase activity
GVI46_RS22870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GVI46_RS22875	COG1420	regulation of RNA biosynthetic process
GVI46_RS22880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GVI46_RS22885	COG0481	GTPase activity
GVI46_RS22895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GVI46_RS22900	COG0268	Binds directly to 16S ribosomal RNA
GVI46_RS22905	COG1466	dna polymerase III delta subunit
GVI46_RS22915	COG0658	competence protein
GVI46_RS22915	COG2333	competence protein COMEC
GVI46_RS22920	COG2131	deaminase
GVI46_RS22925	COG1555	photosystem II stabilization
GVI46_RS22925	COG1596	polysaccharide export
GVI46_RS22930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GVI46_RS22935	COG2226	methyltransferase
GVI46_RS22940	COG0799	negative regulation of ribosome biogenesis
GVI46_RS22945	COG1713	HD superfamily hydrolase involved in NAD metabolism
GVI46_RS22950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GVI46_RS22955	COG1534	Rna-binding protein
GVI46_RS22960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GVI46_RS22965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GVI46_RS22970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GVI46_RS22980	COG0688	phosphatidylethanolamine metabolic process
GVI46_RS22985	COG1183	phosphatidylcholine synthase activity
GVI46_RS22990	COG1191	sigma factor activity
GVI46_RS23005	COG0626	cystathionine gamma-synthase activity
GVI46_RS23010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GVI46_RS23015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GVI46_RS23020	COG2226	methyltransferase
GVI46_RS23035	COG0768	penicillin binding
GVI46_RS23040	COG1335	isochorismatase
GVI46_RS23045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GVI46_RS23050	COG0572	uridine kinase
GVI46_RS23070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GVI46_RS23075	COG3906	Belongs to the UPF0473 family
GVI46_RS23085	COG4472	Bacterial protein of unknown function (DUF965)
GVI46_RS23095	COG0628	permease
GVI46_RS23110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVI46_RS23120	COG0482	sulfurtransferase activity
GVI46_RS23125	COG1104	cysteine desulfurase activity
GVI46_RS23130	COG1959	2 iron, 2 sulfur cluster binding
GVI46_RS23135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GVI46_RS23140	COG0581	inorganic phosphate transmembrane transporter activity
GVI46_RS23145	COG0573	inorganic phosphate transmembrane transporter activity
GVI46_RS23150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GVI46_RS23155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GVI46_RS23165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GVI46_RS23170	COG0124	histidyl-tRNA synthetase
GVI46_RS23180	COG0860	N-Acetylmuramoyl-L-alanine amidase
GVI46_RS23185	COG1490	D-aminoacyl-tRNA deacylase activity
GVI46_RS23190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GVI46_RS23195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GVI46_RS23200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GVI46_RS23200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GVI46_RS23205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GVI46_RS23205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GVI46_RS23215	COG2244	polysaccharide biosynthetic process
GVI46_RS23220	COG2323	membrane
GVI46_RS23230	COG1862	Preprotein translocase
GVI46_RS23240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GVI46_RS23250	COG2255	four-way junction helicase activity
GVI46_RS23280	COG1388	LysM domain
GVI46_RS23285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GVI46_RS23290	COG0157	Belongs to the NadC ModD family
GVI46_RS23295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GVI46_RS23300	COG1104	cysteine desulfurase activity
GVI46_RS23305	COG1827	regulation of RNA biosynthetic process
GVI46_RS23310	COG0077	Prephenate dehydratase
GVI46_RS23315	COG4492	Belongs to the UPF0735 family
GVI46_RS23320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GVI46_RS23325	COG3290	protein histidine kinase activity
GVI46_RS23335	COG2868	ribosomal protein
GVI46_RS23345	COG1530	ribonuclease E activity
GVI46_RS23350	COG1994	Peptidase M50
GVI46_RS23355	COG0739	heme binding
GVI46_RS23360	COG2894	cell division
GVI46_RS23365	COG0850	regulation of cytokinetic process
GVI46_RS23370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GVI46_RS23375	COG1792	Involved in formation and maintenance of cell shape
GVI46_RS23380	COG1077	Cell shape determining protein MreB Mrl
GVI46_RS23385	COG2003	Belongs to the UPF0758 family
GVI46_RS23390	COG0424	maF-like protein
GVI46_RS23400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GVI46_RS23410	COG2322	membrane
GVI46_RS23415	COG0285	dihydrofolate synthase activity
GVI46_RS23420	COG0525	valine-tRNA ligase activity
GVI46_RS23430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GVI46_RS23435	COG1388	LysM domain
GVI46_RS23440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GVI46_RS23445	COG0113	porphobilinogen synthase activity
GVI46_RS23450	COG1587	Uroporphyrinogen-III synthase
GVI46_RS23455	COG0181	hydroxymethylbilane synthase activity
GVI46_RS23460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GVI46_RS23475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GVI46_RS23480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GVI46_RS23485	COG1067	ATP-dependent peptidase activity
GVI46_RS23485	COG0470	DNA polymerase III
GVI46_RS23490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GVI46_RS23495	COG0544	peptidyl-prolyl cis-trans isomerase activity
GVI46_RS23500	COG0457	Tetratricopeptide repeat
GVI46_RS23500	COG1477	protein flavinylation
GVI46_RS23505	COG0066	3-isopropylmalate dehydratase activity
GVI46_RS23510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GVI46_RS23520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GVI46_RS23525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GVI46_RS23530	COG0440	acetolactate synthase activity
GVI46_RS23535	COG0028	Belongs to the TPP enzyme family
GVI46_RS23545	COG0622	Phosphoesterase
GVI46_RS23560	COG5401	PFAM Sporulation and spore germination
GVI46_RS23565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GVI46_RS23570	COG1846	Transcriptional regulator
GVI46_RS23580	COG0306	phosphate transporter
GVI46_RS23585	COG1392	Phosphate transport regulator
GVI46_RS23590	COG0768	penicillin binding
GVI46_RS23600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GVI46_RS23605	COG0431	NADPH-dependent FMN reductase
GVI46_RS23610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GVI46_RS23615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GVI46_RS23620	COG1116	anion transmembrane transporter activity
GVI46_RS23625	COG0475	glutathione-regulated potassium exporter activity
GVI46_RS23630	COG0490	domain, Protein
GVI46_RS23640	COG2197	response regulator
GVI46_RS23645	COG0824	Thioesterase
GVI46_RS23650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GVI46_RS23655	COG1053	succinate dehydrogenase
GVI46_RS23660	COG2009	succinate dehydrogenase
GVI46_RS23665	COG1719	4-vinyl reductase, 4VR
GVI46_RS23670	COG0527	aspartate kinase activity
GVI46_RS23680	COG3118	belongs to the thioredoxin family
GVI46_RS23685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GVI46_RS23690	COG2086	electron transfer activity
GVI46_RS23695	COG1024	Enoyl-CoA hydratase
GVI46_RS23700	COG1309	transcriptional regulator
GVI46_RS23705	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS23710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GVI46_RS23715	COG3766	membrane
GVI46_RS23720	COG1193	negative regulation of DNA recombination
GVI46_RS23725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GVI46_RS23725	COG1796	DNA polymerase
GVI46_RS23730	COG1286	toxin biosynthetic process
GVI46_RS23735	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GVI46_RS23740	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GVI46_RS23745	COG0072	phenylalanine-tRNA ligase activity
GVI46_RS23745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GVI46_RS23755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GVI46_RS23765	COG1363	Peptidase, m42
GVI46_RS23785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GVI46_RS23790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GVI46_RS23795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GVI46_RS23800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GVI46_RS23810	COG1484	DNA-dependent DNA replication
GVI46_RS23815	COG3611	Membrane attachment protein
GVI46_RS23820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GVI46_RS23830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GVI46_RS23835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GVI46_RS23840	COG0237	dephospho-CoA kinase activity
GVI46_RS23845	COG1971	Probably functions as a manganese efflux pump
GVI46_RS23850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GVI46_RS23855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GVI46_RS23855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GVI46_RS23860	COG5002	protein histidine kinase activity
GVI46_RS23865	COG0745	RESPONSE REGULATOR receiver
GVI46_RS23875	COG0039	L-malate dehydrogenase activity
GVI46_RS23880	COG0538	isocitrate dehydrogenase activity
GVI46_RS23885	COG0372	Belongs to the citrate synthase family
GVI46_RS23890	COG2707	UPF0756 membrane protein
GVI46_RS23895	COG0628	permease
GVI46_RS23900	COG3030	protein affecting phage T7 exclusion by the F plasmid
GVI46_RS23910	COG0825	malonyl-CoA metabolic process
GVI46_RS23915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GVI46_RS23920	COG2186	Transcriptional regulator
GVI46_RS23925	COG0281	malic enzyme
GVI46_RS23930	COG0587	DNA-directed DNA polymerase activity
GVI46_RS23945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GVI46_RS23955	COG4109	DRTGG domain
GVI46_RS23970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GVI46_RS23980	COG0165	Argininosuccinate lyase
GVI46_RS23985	COG0137	argininosuccinate synthase activity
GVI46_RS24000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GVI46_RS24005	COG0827	DNA restriction-modification system
GVI46_RS24010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GVI46_RS24015	COG3874	Sporulation protein YtfJ
GVI46_RS24025	COG1714	RDD family
GVI46_RS24030	COG0616	signal peptide processing
GVI46_RS24035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GVI46_RS24040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GVI46_RS24050	COG0301	tRNA thio-modification
GVI46_RS24055	COG1104	cysteine desulfurase activity
GVI46_RS24060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GVI46_RS24065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GVI46_RS24070	COG1309	transcriptional regulator
GVI46_RS24075	COG1956	GAF domain-containing protein
GVI46_RS24085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GVI46_RS24090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GVI46_RS24095	COG0454	-acetyltransferase
GVI46_RS24100	COG0517	IMP dehydrogenase activity
GVI46_RS24105	COG0123	including yeast histone deacetylase and acetoin utilization protein
GVI46_RS24125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GVI46_RS24125	COG1605	Chorismate mutase
GVI46_RS24130	COG3118	belongs to the thioredoxin family
GVI46_RS24135	COG4980	gas vesicle protein
GVI46_RS24150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GVI46_RS24160	COG1674	ftsk spoiiie
GVI46_RS24165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GVI46_RS24170	COG4848	Belongs to the UPF0354 family
GVI46_RS24175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS24180	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GVI46_RS24185	COG1363	Peptidase, m42
GVI46_RS24190	COG5584	Small secreted protein
GVI46_RS24195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVI46_RS24200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GVI46_RS24210	COG0510	thiamine kinase activity
GVI46_RS24215	COG1523	belongs to the glycosyl hydrolase 13 family
GVI46_RS24225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GVI46_RS24230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GVI46_RS24235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVI46_RS24240	COG1349	DNA-binding transcription factor activity
GVI46_RS24245	COG1187	pseudouridine synthase activity
GVI46_RS24250	COG2244	polysaccharide biosynthetic process
GVI46_RS24255	COG2081	HI0933 family
GVI46_RS24265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVI46_RS24270	COG0495	leucyl-tRNA aminoacylation
GVI46_RS24280	COG2610	gluconate transmembrane transporter activity
GVI46_RS24285	COG2814	Major facilitator Superfamily
GVI46_RS24300	COG1242	4 iron, 4 sulfur cluster binding
GVI46_RS24305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GVI46_RS24315	COG2267	carboxylic ester hydrolase activity
GVI46_RS24320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GVI46_RS24325	COG0671	phosphoesterase, PA-phosphatase related
GVI46_RS24330	COG0438	transferase activity, transferring glycosyl groups
GVI46_RS24335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GVI46_RS24340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GVI46_RS24350	COG1506	peptidase
GVI46_RS24355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GVI46_RS24360	COG1116	anion transmembrane transporter activity
GVI46_RS24365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GVI46_RS24370	COG0494	nUDIX hydrolase
GVI46_RS24380	COG4824	toxin secretion phage lysis holin
GVI46_RS24385	COG0783	Belongs to the Dps family
GVI46_RS24395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GVI46_RS24400	COG0288	reversible hydration of carbon dioxide
GVI46_RS24405	COG0523	cobalamin synthesis protein
GVI46_RS24415	COG0254	rRNA binding
GVI46_RS24420	COG1271	oxidase subunit
GVI46_RS24425	COG1294	oxidase, subunit
GVI46_RS24430	COG0716	FMN binding
GVI46_RS24455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVI46_RS24460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVI46_RS24465	COG4948	Mandelate Racemase Muconate Lactonizing
GVI46_RS24470	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS24475	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GVI46_RS24480	COG0596	Alpha beta hydrolase
GVI46_RS24485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GVI46_RS24490	COG1169	isochorismate synthase
GVI46_RS24495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GVI46_RS24505	COG0058	SHG alpha-glucan phosphorylase activity
GVI46_RS24510	COG0297	glycogen (starch) synthase activity
GVI46_RS24515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GVI46_RS24650	COG0318	PFAM AMP-dependent synthetase and ligase
GVI46_RS24655	COG1285	pathogenesis
GVI46_RS24675	COG0529	Catalyzes the synthesis of activated sulfate
GVI46_RS24685	COG0306	phosphate transporter
GVI46_RS24695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GVI46_RS24700	COG0346	lactoylglutathione lyase activity
GVI46_RS24705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GVI46_RS24715	COG0166	Belongs to the GPI family
GVI46_RS24725	COG2111	Na H antiporter
GVI46_RS24725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GVI46_RS24730	COG2111	Na H antiporter
GVI46_RS24735	COG1006	Multisubunit Na H antiporter MnhC subunit
GVI46_RS24740	COG0651	ATP synthesis coupled electron transport
GVI46_RS24745	COG1863	multisubunit Na H antiporter MnhE subunit
GVI46_RS24750	COG2212	antiporter activity
GVI46_RS24755	COG1320	monovalent cation:proton antiporter activity
GVI46_RS24760	COG1979	alcohol dehydrogenase
GVI46_RS24765	COG2155	Conserved Protein
GVI46_RS24770	COG1098	S1 RNA binding domain
GVI46_RS24775	COG0436	Aminotransferase
GVI46_RS24780	COG1522	sequence-specific DNA binding
GVI46_RS24785	COG2267	carboxylic ester hydrolase activity
GVI46_RS24790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GVI46_RS24795	COG2032	superoxide dismutase activity
GVI46_RS24810	COG5018	Exonuclease
GVI46_RS24815	COG2050	protein possibly involved in aromatic compounds catabolism
GVI46_RS24825	COG1418	mRNA catabolic process
GVI46_RS24835	COG2056	Na+-H+ antiporter family
GVI46_RS24840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GVI46_RS24845	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GVI46_RS24850	COG3584	3D domain protein
GVI46_RS24860	COG1252	NADH dehydrogenase
GVI46_RS24865	COG0492	ferredoxin-NADP+ reductase activity
GVI46_RS24875	COG0316	Belongs to the HesB IscA family
GVI46_RS24880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GVI46_RS24885	COG4844	belongs to the
GVI46_RS24890	COG1252	NADH dehydrogenase
GVI46_RS24895	COG4837	Protein of unknown function (DUF1462)
GVI46_RS24900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GVI46_RS24905	COG0083	homoserine kinase activity
GVI46_RS24910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GVI46_RS24915	COG0460	homoserine dehydrogenase
GVI46_RS24920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GVI46_RS24925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GVI46_RS24930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GVI46_RS24935	COG0647	UMP catabolic process
GVI46_RS24940	COG2445	Protein of unknown function DUF86
GVI46_RS24950	COG4470	Protein conserved in bacteria
GVI46_RS24960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GVI46_RS24965	COG0739	heme binding
GVI46_RS24975	COG0733	neurotransmitter:sodium symporter activity
GVI46_RS24985	COG3377	Domain of unknown function (DUF1805)
GVI46_RS24990	COG1801	Protein of unknown function DUF72
GVI46_RS24995	COG0719	Fe-S assembly protein
GVI46_RS25000	COG0822	iron-sulfur transferase activity
GVI46_RS25005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GVI46_RS25010	COG0719	Fe-S assembly protein
GVI46_RS25015	COG0396	ATPase activity
GVI46_RS25020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GVI46_RS25025	COG1464	Belongs to the NlpA lipoprotein family
GVI46_RS25030	COG2011	ABC-type metal ion transport system permease component
GVI46_RS25035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GVI46_RS25040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVI46_RS25045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GVI46_RS25055	COG0509	glycine decarboxylation via glycine cleavage system
GVI46_RS25060	COG1393	Belongs to the ArsC family
GVI46_RS25065	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS25070	COG0183	Belongs to the thiolase family
GVI46_RS25075	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVI46_RS25075	COG1024	Enoyl-CoA hydratase
GVI46_RS25100	COG1120	ATPase activity
GVI46_RS25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVI46_RS25115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GVI46_RS25125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GVI46_RS25130	COG1309	transcriptional regulator
GVI46_RS25140	COG1028	Short-chain dehydrogenase reductase Sdr
GVI46_RS25145	COG0477	Major facilitator Superfamily
GVI46_RS25155	COG5002	protein histidine kinase activity
GVI46_RS25155	COG3850	Histidine kinase
GVI46_RS25160	COG0745	RESPONSE REGULATOR receiver
GVI46_RS25165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GVI46_RS25170	COG0671	phosphoesterase, PA-phosphatase related
GVI46_RS25175	COG1846	Transcriptional regulator
GVI46_RS25180	COG0778	Nitroreductase
GVI46_RS25185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GVI46_RS25190	COG0314	molybdopterin synthase activity
GVI46_RS25195	COG1763	Mo-molybdopterin cofactor biosynthetic process
GVI46_RS25200	COG0303	'Molybdopterin
GVI46_RS25205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GVI46_RS25210	COG0746	molybdenum cofactor guanylyltransferase activity
GVI46_RS25220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GVI46_RS25225	COG5609	conserved protein (DUF2294)
GVI46_RS25230	COG3383	formate dehydrogenase (NAD+) activity
GVI46_RS25235	COG2427	Protein of unknown function (DUF1641)
GVI46_RS25240	COG0725	ABC transporter, periplasmic molybdate-binding protein
GVI46_RS25245	COG4149	molybdate abc transporter
GVI46_RS25255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GVI46_RS25260	COG0557	exoribonuclease II activity
GVI46_RS25265	COG1647	Serine aminopeptidase, S33
GVI46_RS25270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GVI46_RS25280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GVI46_RS25310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GVI46_RS25330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVI46_RS25340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GVI46_RS25345	COG1660	Displays ATPase and GTPase activities
GVI46_RS25350	COG1051	belongs to the nudix hydrolase family
GVI46_RS25355	COG0492	ferredoxin-NADP+ reductase activity
GVI46_RS25360	COG0457	Tetratricopeptide repeat
GVI46_RS25365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GVI46_RS25365	COG0140	phosphoribosyl-ATP diphosphatase activity
GVI46_RS25370	COG0107	imidazoleglycerol-phosphate synthase activity
GVI46_RS25375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GVI46_RS25380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GVI46_RS25385	COG0131	Imidazoleglycerol-phosphate dehydratase
GVI46_RS25390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GVI46_RS25395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GVI46_RS25400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GVI46_RS25405	COG0110	maltose O-acetyltransferase activity
GVI46_RS25410	COG0546	phosphoglycolate phosphatase activity
GVI46_RS25415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GVI46_RS25420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GVI46_RS25425	COG1950	PFAM Membrane protein of
GVI46_RS25435	COG3595	metallopeptidase activity
GVI46_RS25445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GVI46_RS25450	COG0556	nucleotide-excision repair
GVI46_RS25455	COG2204	response regulator
GVI46_RS25460	COG1012	belongs to the aldehyde dehydrogenase family
GVI46_RS25465	COG0506	proline dehydrogenase activity
GVI46_RS25470	COG4897	Protein conserved in bacteria
GVI46_RS25475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVI46_RS25480	COG0793	Belongs to the peptidase S41A family
GVI46_RS25480	COG3409	Peptidoglycan-binding domain 1 protein
GVI46_RS25485	COG0739	heme binding
GVI46_RS25490	COG2177	Part of the ABC transporter FtsEX involved in
GVI46_RS25495	COG2884	Cell division ATP-binding protein ftsE
GVI46_RS25500	COG0655	NAD(P)H dehydrogenase (quinone) activity
GVI46_RS25510	COG0805	protein transport
GVI46_RS25515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVI46_RS25520	COG3540	Alkaline phosphatase
GVI46_RS25530	COG0653	protein targeting
GVI46_RS25535	COG0456	acetyltransferase
GVI46_RS25540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GVI46_RS25550	COG1516	flagellar protein fliS
GVI46_RS25555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GVI46_RS25565	COG1113	amino acid transport
GVI46_RS25580	COG1454	alcohol dehydrogenase
GVI46_RS25585	COG1510	regulation of RNA biosynthetic process
GVI46_RS25590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GVI46_RS25595	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GVI46_RS25600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GVI46_RS25605	COG4786	Flagellar basal body rod
GVI46_RS25605	COG1256	bacterial-type flagellum assembly
GVI46_RS25625	COG1040	competence protein
GVI46_RS25630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GVI46_RS25635	COG1307	EDD domain protein, DegV family
GVI46_RS25640	COG1728	Protein conserved in bacteria
GVI46_RS25650	COG2197	response regulator
GVI46_RS25655	COG4585	Histidine kinase
GVI46_RS25660	COG1739	Uncharacterized protein family UPF0029
GVI46_RS25665	COG1316	TRANSCRIPTIONal
GVI46_RS25670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GVI46_RS25675	COG1585	Membrane protein implicated in regulation of membrane protease activity
GVI46_RS25680	COG2268	Band 7 protein
GVI46_RS25685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GVI46_RS25695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVI46_RS25705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GVI46_RS25710	COG0791	NLP P60 protein
GVI46_RS25710	COG1388	LysM domain
GVI46_RS25715	COG0629	single-stranded DNA binding
GVI46_RS25735	COG4786	Flagellar basal body rod
GVI46_RS25740	COG4786	Flagellar basal body rod
GVI46_RS25745	COG1077	Cell shape determining protein MreB Mrl
GVI46_RS25750	COG1609	Transcriptional regulator
GVI46_RS25755	COG0739	heme binding
GVI46_RS25760	COG2385	sporulation resulting in formation of a cellular spore
GVI46_RS25775	COG4836	Membrane
GVI46_RS25780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GVI46_RS25785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GVI46_RS25790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GVI46_RS25795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GVI46_RS25800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GVI46_RS25805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GVI46_RS25810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GVI46_RS25815	COG0356	it plays a direct role in the translocation of protons across the membrane
GVI46_RS25830	COG1404	Belongs to the peptidase S8 family
GVI46_RS25835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GVI46_RS25840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GVI46_RS25855	COG0698	ribose 5-phosphate isomerase
GVI46_RS25865	COG1971	Probably functions as a manganese efflux pump
GVI46_RS25870	COG0009	L-threonylcarbamoyladenylate synthase
GVI46_RS25890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GVI46_RS25905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GVI46_RS25915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GVI46_RS25920	COG0191	fructose-bisphosphate aldolase activity
GVI46_RS25925	COG2204	response regulator
GVI46_RS25930	COG4821	SIS domain
GVI46_RS25935	COG0504	CTP synthase activity
GVI46_RS25945	COG1703	isobutyryl-CoA mutase activity
GVI46_RS25945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GVI46_RS25945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GVI46_RS25955	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS25960	COG1960	acyl-CoA dehydrogenase activity
GVI46_RS25965	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVI46_RS25970	COG0183	Belongs to the thiolase family
GVI46_RS25975	COG0247	lactate metabolic process
GVI46_RS25975	COG2181	nitrate reductase activity
GVI46_RS25980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GVI46_RS25995	COG4506	Protein conserved in bacteria
GVI46_RS26000	COG0010	Belongs to the arginase family
GVI46_RS26005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GVI46_RS26010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GVI46_RS26020	COG1994	Peptidase M50
GVI46_RS26025	COG1942	4-Oxalocrotonate Tautomerase
GVI46_RS26030	COG3465	dGTPase activity
GVI46_RS26035	COG1078	dGTPase activity
GVI46_RS26040	COG4844	belongs to the
GVI46_RS26050	COG0095	Lipoate-protein ligase
GVI46_RS26055	COG0280	phosphate acetyltransferase
GVI46_RS26065	COG3773	Cell wall hydrolase
GVI46_RS26075	COG2363	Small membrane protein
GVI46_RS26085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GVI46_RS26095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GVI46_RS26100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GVI46_RS26105	COG2508	Transcriptional regulator
GVI46_RS26105	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GVI46_RS26110	COG0686	Belongs to the AlaDH PNT family
GVI46_RS26120	COG0351	phosphomethylpyrimidine kinase
GVI46_RS26125	COG0561	phosphatase activity
GVI46_RS26130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GVI46_RS26135	COG2190	(PTS) system
GVI46_RS26135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVI46_RS26135	COG1263	PTS System
GVI46_RS26145	COG0438	transferase activity, transferring glycosyl groups
GVI46_RS26160	COG2076	Multidrug Resistance protein
GVI46_RS26170	COG0728	peptidoglycan biosynthetic process
GVI46_RS26185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GVI46_RS26190	COG4988	ABC transporter
GVI46_RS26195	COG1294	oxidase, subunit
GVI46_RS26200	COG1271	oxidase subunit
GVI46_RS26205	COG3610	response to peptide
GVI46_RS26210	COG2966	Psort location CytoplasmicMembrane, score
GVI46_RS26215	COG1609	Transcriptional regulator
GVI46_RS26225	COG2814	Major facilitator Superfamily
GVI46_RS26240	COG1966	Carbon starvation protein
GVI46_RS26245	COG0753	catalase activity
GVI46_RS26255	COG0471	metal ion transport
GVI46_RS26260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GVI46_RS26270	COG0745	RESPONSE REGULATOR receiver
GVI46_RS26275	COG5002	protein histidine kinase activity
GVI46_RS26290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GVI46_RS26295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GVI46_RS26305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVI46_RS26310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GVI46_RS26315	COG4853	Protein conserved in bacteria
GVI46_RS26325	COG5002	protein histidine kinase activity
GVI46_RS26330	COG0745	RESPONSE REGULATOR receiver
GVI46_RS26355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GVI46_RS26360	COG0305	Participates in initiation and elongation during chromosome replication
GVI46_RS26370	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GVI46_RS26380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GVI46_RS26395	COG0012	GTP binding
GVI46_RS26400	COG4481	Protein conserved in bacteria
GVI46_RS26405	COG0668	transmembrane transport
GVI46_RS26410	COG3949	Membrane
GVI46_RS26420	COG1475	DNA binding
GVI46_RS26425	COG1192	Involved in chromosome partitioning
GVI46_RS26430	COG1475	DNA binding
GVI46_RS26440	COG0445	tRNA wobble uridine modification
GVI46_RS26445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GVI46_RS26450	COG1847	R3H domain protein
GVI46_RS26455	COG0706	membrane insertase activity
GVI46_RS26460	COG0594	ribonuclease P activity
GVI46_RS26465	COG0230	Belongs to the bacterial ribosomal protein bL34 family