locus-tag	class	description
HW369_RS00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW369_RS00010	COG0187	DNA topoisomerase II activity
HW369_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW369_RS00020	COG2501	S4 domain
HW369_RS00025	COG0592	DNA-directed DNA polymerase activity
HW369_RS00030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW369_RS00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HW369_RS00040	COG0594	ribonuclease P activity
HW369_RS00045	COG0706	membrane insertase activity
HW369_RS00050	COG1847	R3H domain protein
HW369_RS00055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW369_RS00060	COG0445	tRNA wobble uridine modification
HW369_RS00070	COG1475	DNA binding
HW369_RS00075	COG1192	Involved in chromosome partitioning
HW369_RS00080	COG1475	DNA binding
HW369_RS00090	COG3949	Membrane
HW369_RS00095	COG0668	transmembrane transport
HW369_RS00100	COG4481	Protein conserved in bacteria
HW369_RS00105	COG0012	GTP binding
HW369_RS00110	COG0360	Binds together with S18 to 16S ribosomal RNA
HW369_RS00120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW369_RS00130	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HW369_RS00140	COG0305	Participates in initiation and elongation during chromosome replication
HW369_RS00145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW369_RS00170	COG0745	RESPONSE REGULATOR receiver
HW369_RS00175	COG5002	protein histidine kinase activity
HW369_RS00185	COG4853	Protein conserved in bacteria
HW369_RS00190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW369_RS00195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW369_RS00205	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HW369_RS00210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW369_RS00220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW369_RS00225	COG0471	metal ion transport
HW369_RS00240	COG5002	protein histidine kinase activity
HW369_RS00245	COG0753	catalase activity
HW369_RS00250	COG1966	Carbon starvation protein
HW369_RS00265	COG2814	Major facilitator Superfamily
HW369_RS00275	COG1609	Transcriptional regulator
HW369_RS00280	COG2966	Psort location CytoplasmicMembrane, score
HW369_RS00285	COG3610	response to peptide
HW369_RS00290	COG1271	oxidase subunit
HW369_RS00295	COG1294	oxidase, subunit
HW369_RS00300	COG4988	ABC transporter
HW369_RS00305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW369_RS00320	COG0728	peptidoglycan biosynthetic process
HW369_RS00330	COG2076	Multidrug Resistance protein
HW369_RS00345	COG0438	transferase activity, transferring glycosyl groups
HW369_RS00355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS00355	COG1263	PTS System
HW369_RS00355	COG2190	(PTS) system
HW369_RS00360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW369_RS00365	COG0561	phosphatase activity
HW369_RS00370	COG0351	phosphomethylpyrimidine kinase
HW369_RS00380	COG0686	Belongs to the AlaDH PNT family
HW369_RS00385	COG2508	Transcriptional regulator
HW369_RS00385	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW369_RS00390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW369_RS00395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW369_RS00405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HW369_RS00415	COG2363	Small membrane protein
HW369_RS00425	COG3773	Cell wall hydrolase
HW369_RS00430	COG3253	May function as heme-dependent peroxidase
HW369_RS00435	COG0280	phosphate acetyltransferase
HW369_RS00440	COG0095	Lipoate-protein ligase
HW369_RS00450	COG4844	belongs to the
HW369_RS00455	COG1078	dGTPase activity
HW369_RS00460	COG3465	dGTPase activity
HW369_RS00465	COG1942	4-Oxalocrotonate Tautomerase
HW369_RS00470	COG1994	Peptidase M50
HW369_RS00480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW369_RS00485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW369_RS00490	COG0010	Belongs to the arginase family
HW369_RS00495	COG4506	Protein conserved in bacteria
HW369_RS00500	COG0018	arginyl-trna synthetase
HW369_RS00510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS00515	COG2181	nitrate reductase activity
HW369_RS00515	COG0247	lactate metabolic process
HW369_RS00520	COG0183	Belongs to the thiolase family
HW369_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW369_RS00530	COG1960	acyl-CoA dehydrogenase activity
HW369_RS00535	COG1960	acyl-CoA dehydrogenase activity
HW369_RS00545	COG1703	isobutyryl-CoA mutase activity
HW369_RS00545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS00545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS00555	COG0504	CTP synthase activity
HW369_RS00560	COG4821	SIS domain
HW369_RS00565	COG2204	response regulator
HW369_RS00570	COG0191	fructose-bisphosphate aldolase activity
HW369_RS00575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW369_RS00585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW369_RS00600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW369_RS00620	COG0009	L-threonylcarbamoyladenylate synthase
HW369_RS00625	COG1971	Probably functions as a manganese efflux pump
HW369_RS00640	COG0698	ribose 5-phosphate isomerase
HW369_RS00655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW369_RS00660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW369_RS00665	COG1404	Belongs to the peptidase S8 family
HW369_RS00680	COG0356	it plays a direct role in the translocation of protons across the membrane
HW369_RS00685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW369_RS00690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW369_RS00695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW369_RS00700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW369_RS00705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW369_RS00710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW369_RS00715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW369_RS00720	COG4836	Membrane
HW369_RS00735	COG2385	sporulation resulting in formation of a cellular spore
HW369_RS00740	COG0739	heme binding
HW369_RS00745	COG1609	Transcriptional regulator
HW369_RS00750	COG1077	Cell shape determining protein MreB Mrl
HW369_RS00755	COG4786	Flagellar basal body rod
HW369_RS00760	COG4786	Flagellar basal body rod
HW369_RS00780	COG0629	single-stranded DNA binding
HW369_RS00785	COG0791	NLP P60 protein
HW369_RS00785	COG1388	LysM domain
HW369_RS00790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW369_RS00800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW369_RS00810	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HW369_RS00815	COG2268	Band 7 protein
HW369_RS00820	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW369_RS00825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW369_RS00830	COG1316	TRANSCRIPTIONal
HW369_RS00835	COG1739	Uncharacterized protein family UPF0029
HW369_RS00840	COG4585	Histidine kinase
HW369_RS00845	COG2197	response regulator
HW369_RS00855	COG1728	Protein conserved in bacteria
HW369_RS00860	COG1307	EDD domain protein, DegV family
HW369_RS00865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HW369_RS00870	COG1040	competence protein
HW369_RS00890	COG1256	bacterial-type flagellum assembly
HW369_RS00890	COG4786	Flagellar basal body rod
HW369_RS00895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW369_RS00900	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HW369_RS00905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW369_RS00910	COG1510	regulation of RNA biosynthetic process
HW369_RS00915	COG1454	alcohol dehydrogenase
HW369_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS00930	COG1113	amino acid transport
HW369_RS00940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW369_RS00945	COG1516	flagellar protein fliS
HW369_RS00955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW369_RS00960	COG0456	acetyltransferase
HW369_RS00965	COG0653	protein targeting
HW369_RS00975	COG3540	Alkaline phosphatase
HW369_RS00980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW369_RS00985	COG0805	protein transport
HW369_RS00995	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW369_RS01000	COG2884	Cell division ATP-binding protein ftsE
HW369_RS01005	COG2177	Part of the ABC transporter FtsEX involved in
HW369_RS01010	COG0739	heme binding
HW369_RS01015	COG3409	Peptidoglycan-binding domain 1 protein
HW369_RS01015	COG0793	Belongs to the peptidase S41A family
HW369_RS01020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW369_RS01025	COG4897	Protein conserved in bacteria
HW369_RS01030	COG0506	proline dehydrogenase activity
HW369_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS01040	COG2204	response regulator
HW369_RS01045	COG0556	nucleotide-excision repair
HW369_RS01050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW369_RS01060	COG3595	metallopeptidase activity
HW369_RS01070	COG1950	PFAM Membrane protein of
HW369_RS01075	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW369_RS01080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HW369_RS01085	COG0546	phosphoglycolate phosphatase activity
HW369_RS01090	COG0110	maltose O-acetyltransferase activity
HW369_RS01095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HW369_RS01100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW369_RS01105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW369_RS01110	COG0131	Imidazoleglycerol-phosphate dehydratase
HW369_RS01115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW369_RS01120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW369_RS01125	COG0107	imidazoleglycerol-phosphate synthase activity
HW369_RS01130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW369_RS01130	COG0140	phosphoribosyl-ATP diphosphatase activity
HW369_RS01135	COG0457	Tetratricopeptide repeat
HW369_RS01140	COG0492	ferredoxin-NADP+ reductase activity
HW369_RS01145	COG1051	belongs to the nudix hydrolase family
HW369_RS01150	COG1660	Displays ATPase and GTPase activities
HW369_RS01155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW369_RS01165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW369_RS01185	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW369_RS01225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW369_RS01230	COG1647	Serine aminopeptidase, S33
HW369_RS01235	COG0557	exoribonuclease II activity
HW369_RS01240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW369_RS01250	COG4149	molybdate abc transporter
HW369_RS01255	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW369_RS01260	COG2427	Protein of unknown function (DUF1641)
HW369_RS01265	COG3383	formate dehydrogenase (NAD+) activity
HW369_RS01270	COG5609	conserved protein (DUF2294)
HW369_RS01275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW369_RS01285	COG0746	molybdenum cofactor guanylyltransferase activity
HW369_RS01290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW369_RS01295	COG0303	'Molybdopterin
HW369_RS01300	COG1763	Mo-molybdopterin cofactor biosynthetic process
HW369_RS01305	COG0314	molybdopterin synthase activity
HW369_RS01310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW369_RS01315	COG0778	Nitroreductase
HW369_RS01320	COG1846	Transcriptional regulator
HW369_RS01330	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS01335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW369_RS01340	COG0745	RESPONSE REGULATOR receiver
HW369_RS01345	COG5002	protein histidine kinase activity
HW369_RS01345	COG3850	Histidine kinase
HW369_RS01355	COG0583	DNA-binding transcription factor activity
HW369_RS01360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW369_RS01365	COG0477	Major facilitator Superfamily
HW369_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS01380	COG1309	transcriptional regulator
HW369_RS01385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW369_RS01400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW369_RS01405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS01410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS01415	COG1120	ATPase activity
HW369_RS01440	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW369_RS01440	COG1024	Enoyl-CoA hydratase
HW369_RS01445	COG0183	Belongs to the thiolase family
HW369_RS01450	COG1960	acyl-CoA dehydrogenase activity
HW369_RS01455	COG1393	Belongs to the ArsC family
HW369_RS01460	COG0509	glycine decarboxylation via glycine cleavage system
HW369_RS01470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HW369_RS01475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS01480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW369_RS01485	COG2011	ABC-type metal ion transport system permease component
HW369_RS01490	COG1464	Belongs to the NlpA lipoprotein family
HW369_RS01495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW369_RS01500	COG0396	ATPase activity
HW369_RS01505	COG0719	Fe-S assembly protein
HW369_RS01510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW369_RS01515	COG0822	iron-sulfur transferase activity
HW369_RS01520	COG0719	Fe-S assembly protein
HW369_RS01525	COG1801	Protein of unknown function DUF72
HW369_RS01530	COG3377	Domain of unknown function (DUF1805)
HW369_RS01540	COG0733	neurotransmitter:sodium symporter activity
HW369_RS01550	COG0739	heme binding
HW369_RS01555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW369_RS01565	COG4470	Protein conserved in bacteria
HW369_RS01575	COG2445	Protein of unknown function DUF86
HW369_RS01580	COG0647	UMP catabolic process
HW369_RS01585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW369_RS01590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW369_RS01595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW369_RS01600	COG0460	homoserine dehydrogenase
HW369_RS01605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW369_RS01610	COG0083	homoserine kinase activity
HW369_RS01615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HW369_RS01620	COG4837	Protein of unknown function (DUF1462)
HW369_RS01625	COG1252	NADH dehydrogenase
HW369_RS01630	COG4844	belongs to the
HW369_RS01635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW369_RS01640	COG0316	Belongs to the HesB IscA family
HW369_RS01650	COG0492	ferredoxin-NADP+ reductase activity
HW369_RS01655	COG1252	NADH dehydrogenase
HW369_RS01665	COG3584	3D domain protein
HW369_RS01670	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HW369_RS01675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW369_RS01680	COG2056	Na+-H+ antiporter family
HW369_RS01690	COG1418	mRNA catabolic process
HW369_RS01700	COG2050	protein possibly involved in aromatic compounds catabolism
HW369_RS01705	COG5018	Exonuclease
HW369_RS01720	COG2032	superoxide dismutase activity
HW369_RS01725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW369_RS01730	COG2267	carboxylic ester hydrolase activity
HW369_RS01735	COG1522	sequence-specific DNA binding
HW369_RS01740	COG0436	Aminotransferase
HW369_RS01745	COG1098	S1 RNA binding domain
HW369_RS01750	COG2155	Conserved Protein
HW369_RS01755	COG1979	alcohol dehydrogenase
HW369_RS01760	COG1320	monovalent cation:proton antiporter activity
HW369_RS01765	COG2212	antiporter activity
HW369_RS01770	COG1863	multisubunit Na H antiporter MnhE subunit
HW369_RS01775	COG0651	ATP synthesis coupled electron transport
HW369_RS01780	COG1006	Multisubunit Na H antiporter MnhC subunit
HW369_RS01785	COG2111	Na H antiporter
HW369_RS01790	COG2111	Na H antiporter
HW369_RS01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW369_RS01800	COG0166	Belongs to the GPI family
HW369_RS01810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW369_RS01815	COG0346	lactoylglutathione lyase activity
HW369_RS01820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW369_RS01830	COG0306	phosphate transporter
HW369_RS01840	COG0529	Catalyzes the synthesis of activated sulfate
HW369_RS01860	COG1285	pathogenesis
HW369_RS01865	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS02000	COG2340	Cysteine-rich secretory protein family
HW369_RS02030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW369_RS02035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW369_RS02040	COG0297	glycogen (starch) synthase activity
HW369_RS02045	COG0058	SHG alpha-glucan phosphorylase activity
HW369_RS02055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW369_RS02060	COG1169	isochorismate synthase
HW369_RS02065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW369_RS02070	COG0596	Alpha beta hydrolase
HW369_RS02075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW369_RS02080	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS02085	COG4948	Mandelate Racemase Muconate Lactonizing
HW369_RS02090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW369_RS02095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW369_RS02120	COG0716	FMN binding
HW369_RS02125	COG1294	oxidase, subunit
HW369_RS02130	COG1271	oxidase subunit
HW369_RS02135	COG0254	rRNA binding
HW369_RS02145	COG0523	cobalamin synthesis protein
HW369_RS02150	COG0288	reversible hydration of carbon dioxide
HW369_RS02155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW369_RS02165	COG0783	Belongs to the Dps family
HW369_RS02170	COG4824	toxin secretion phage lysis holin
HW369_RS02180	COG0494	nUDIX hydrolase
HW369_RS02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW369_RS02190	COG1116	anion transmembrane transporter activity
HW369_RS02195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW369_RS02200	COG1506	peptidase
HW369_RS02210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HW369_RS02215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW369_RS02220	COG0438	transferase activity, transferring glycosyl groups
HW369_RS02220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW369_RS02225	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS02230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW369_RS02235	COG2267	carboxylic ester hydrolase activity
HW369_RS02245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HW369_RS02250	COG1242	4 iron, 4 sulfur cluster binding
HW369_RS02265	COG2814	Major facilitator Superfamily
HW369_RS02270	COG2610	gluconate transmembrane transporter activity
HW369_RS02275	COG0495	leucyl-tRNA aminoacylation
HW369_RS02280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW369_RS02290	COG2081	HI0933 family
HW369_RS02295	COG2244	polysaccharide biosynthetic process
HW369_RS02300	COG1187	pseudouridine synthase activity
HW369_RS02305	COG1349	DNA-binding transcription factor activity
HW369_RS02310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW369_RS02315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW369_RS02320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW369_RS02330	COG1523	belongs to the glycosyl hydrolase 13 family
HW369_RS02335	COG0510	thiamine kinase activity
HW369_RS02345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW369_RS02350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS02355	COG5584	Small secreted protein
HW369_RS02360	COG1363	Peptidase, m42
HW369_RS02365	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HW369_RS02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS02375	COG4848	Belongs to the UPF0354 family
HW369_RS02380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW369_RS02385	COG1674	ftsk spoiiie
HW369_RS02395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW369_RS02410	COG4980	gas vesicle protein
HW369_RS02415	COG3118	belongs to the thioredoxin family
HW369_RS02420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW369_RS02420	COG1605	Chorismate mutase
HW369_RS02440	COG0123	including yeast histone deacetylase and acetoin utilization protein
HW369_RS02445	COG0517	IMP dehydrogenase activity
HW369_RS02450	COG0454	-acetyltransferase
HW369_RS02455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW369_RS02470	COG1956	GAF domain-containing protein
HW369_RS02475	COG1309	transcriptional regulator
HW369_RS02480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW369_RS02485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HW369_RS02490	COG1114	Component of the transport system for branched-chain amino acids
HW369_RS02495	COG1104	cysteine desulfurase activity
HW369_RS02500	COG0301	tRNA thio-modification
HW369_RS02510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HW369_RS02515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW369_RS02520	COG0616	signal peptide processing
HW369_RS02525	COG1714	RDD family
HW369_RS02535	COG3874	Sporulation protein YtfJ
HW369_RS02540	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW369_RS02545	COG0827	DNA restriction-modification system
HW369_RS02550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW369_RS02565	COG0137	argininosuccinate synthase activity
HW369_RS02570	COG0165	Argininosuccinate lyase
HW369_RS02585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW369_RS02600	COG4109	DRTGG domain
HW369_RS02610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HW369_RS02625	COG0587	DNA-directed DNA polymerase activity
HW369_RS02630	COG0281	malic enzyme
HW369_RS02635	COG2186	Transcriptional regulator
HW369_RS02640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW369_RS02645	COG0825	malonyl-CoA metabolic process
HW369_RS02655	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW369_RS02660	COG0628	permease
HW369_RS02665	COG2707	UPF0756 membrane protein
HW369_RS02670	COG0372	Belongs to the citrate synthase family
HW369_RS02675	COG0538	isocitrate dehydrogenase activity
HW369_RS02680	COG0039	L-malate dehydrogenase activity
HW369_RS02690	COG0745	RESPONSE REGULATOR receiver
HW369_RS02695	COG5002	protein histidine kinase activity
HW369_RS02700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW369_RS02700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW369_RS02705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW369_RS02710	COG1971	Probably functions as a manganese efflux pump
HW369_RS02715	COG0237	dephospho-CoA kinase activity
HW369_RS02720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW369_RS02725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW369_RS02735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW369_RS02740	COG3611	Membrane attachment protein
HW369_RS02745	COG1484	DNA-dependent DNA replication
HW369_RS02755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW369_RS02760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW369_RS02765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW369_RS02770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW369_RS02790	COG1363	Peptidase, m42
HW369_RS02800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW369_RS02805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW369_RS02810	COG0072	phenylalanine-tRNA ligase activity
HW369_RS02810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW369_RS02815	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW369_RS02820	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HW369_RS02825	COG1286	toxin biosynthetic process
HW369_RS02830	COG1796	DNA polymerase
HW369_RS02830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW369_RS02835	COG1193	negative regulation of DNA recombination
HW369_RS02840	COG3766	membrane
HW369_RS02845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW369_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS02855	COG1309	transcriptional regulator
HW369_RS02860	COG1024	Enoyl-CoA hydratase
HW369_RS02865	COG2086	electron transfer activity
HW369_RS02870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW369_RS02875	COG3118	belongs to the thioredoxin family
HW369_RS02885	COG0527	aspartate kinase activity
HW369_RS02890	COG1719	4-vinyl reductase, 4VR
HW369_RS02895	COG2009	succinate dehydrogenase
HW369_RS02900	COG1053	succinate dehydrogenase
HW369_RS02905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW369_RS02910	COG0824	Thioesterase
HW369_RS02915	COG2197	response regulator
HW369_RS02925	COG0490	domain, Protein
HW369_RS02930	COG0475	glutathione-regulated potassium exporter activity
HW369_RS02935	COG1116	anion transmembrane transporter activity
HW369_RS02940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW369_RS02945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW369_RS02950	COG0431	NADPH-dependent FMN reductase
HW369_RS02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS02960	COG0768	penicillin binding
HW369_RS02965	COG1392	Phosphate transport regulator
HW369_RS02970	COG0306	phosphate transporter
HW369_RS02980	COG1846	Transcriptional regulator
HW369_RS02985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW369_RS02990	COG5401	PFAM Sporulation and spore germination
HW369_RS03000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW369_RS03005	COG0622	Phosphoesterase
HW369_RS03015	COG0028	Belongs to the TPP enzyme family
HW369_RS03020	COG0440	acetolactate synthase activity
HW369_RS03025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW369_RS03030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW369_RS03040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW369_RS03045	COG0066	3-isopropylmalate dehydratase activity
HW369_RS03050	COG1477	protein flavinylation
HW369_RS03050	COG0457	Tetratricopeptide repeat
HW369_RS03055	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW369_RS03060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW369_RS03065	COG1067	ATP-dependent peptidase activity
HW369_RS03065	COG0470	DNA polymerase III
HW369_RS03070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW369_RS03075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HW369_RS03090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW369_RS03095	COG0181	hydroxymethylbilane synthase activity
HW369_RS03100	COG1587	Uroporphyrinogen-III synthase
HW369_RS03105	COG0113	porphobilinogen synthase activity
HW369_RS03110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW369_RS03115	COG1388	LysM domain
HW369_RS03120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW369_RS03130	COG0525	valine-tRNA ligase activity
HW369_RS03135	COG0285	dihydrofolate synthase activity
HW369_RS03140	COG2322	membrane
HW369_RS03150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HW369_RS03160	COG0424	maF-like protein
HW369_RS03165	COG2003	Belongs to the UPF0758 family
HW369_RS03170	COG1077	Cell shape determining protein MreB Mrl
HW369_RS03175	COG1792	Involved in formation and maintenance of cell shape
HW369_RS03180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HW369_RS03185	COG0850	regulation of cytokinetic process
HW369_RS03190	COG2894	cell division
HW369_RS03195	COG0739	heme binding
HW369_RS03200	COG1994	Peptidase M50
HW369_RS03205	COG1530	ribonuclease E activity
HW369_RS03215	COG2868	ribosomal protein
HW369_RS03225	COG3290	protein histidine kinase activity
HW369_RS03230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW369_RS03235	COG4492	Belongs to the UPF0735 family
HW369_RS03240	COG0077	Prephenate dehydratase
HW369_RS03245	COG1827	regulation of RNA biosynthetic process
HW369_RS03250	COG1104	cysteine desulfurase activity
HW369_RS03255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW369_RS03260	COG0157	Belongs to the NadC ModD family
HW369_RS03265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HW369_RS03270	COG1388	LysM domain
HW369_RS03295	COG0632	four-way junction helicase activity
HW369_RS03300	COG2255	four-way junction helicase activity
HW369_RS03310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HW369_RS03315	COG0343	queuine tRNA-ribosyltransferase activity
HW369_RS03320	COG1862	Preprotein translocase
HW369_RS03330	COG2323	membrane
HW369_RS03335	COG2244	polysaccharide biosynthetic process
HW369_RS03345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW369_RS03345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW369_RS03350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW369_RS03350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW369_RS03355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW369_RS03360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW369_RS03365	COG1490	D-aminoacyl-tRNA deacylase activity
HW369_RS03370	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS03380	COG0124	histidyl-tRNA synthetase
HW369_RS03385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW369_RS03395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW369_RS03400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW369_RS03405	COG0573	inorganic phosphate transmembrane transporter activity
HW369_RS03410	COG0581	inorganic phosphate transmembrane transporter activity
HW369_RS03415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW369_RS03420	COG1959	2 iron, 2 sulfur cluster binding
HW369_RS03425	COG1104	cysteine desulfurase activity
HW369_RS03430	COG0482	sulfurtransferase activity
HW369_RS03440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW369_RS03455	COG0628	permease
HW369_RS03465	COG4472	Bacterial protein of unknown function (DUF965)
HW369_RS03475	COG3906	Belongs to the UPF0473 family
HW369_RS03480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW369_RS03485	COG4122	O-methyltransferase activity
HW369_RS03490	COG0826	peptidase U32
HW369_RS03495	COG0826	peptidase U32
HW369_RS03500	COG0572	uridine kinase
HW369_RS03505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW369_RS03510	COG1335	isochorismatase
HW369_RS03515	COG0768	penicillin binding
HW369_RS03530	COG2226	methyltransferase
HW369_RS03535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW369_RS03540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW369_RS03545	COG0626	cystathionine gamma-synthase activity
HW369_RS03570	COG1183	phosphatidylcholine synthase activity
HW369_RS03575	COG0688	phosphatidylethanolamine metabolic process
HW369_RS03585	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HW369_RS03590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW369_RS03595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW369_RS03600	COG1534	Rna-binding protein
HW369_RS03605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW369_RS03610	COG1713	HD superfamily hydrolase involved in NAD metabolism
HW369_RS03615	COG0799	negative regulation of ribosome biogenesis
HW369_RS03620	COG2226	methyltransferase
HW369_RS03625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW369_RS03630	COG1555	photosystem II stabilization
HW369_RS03630	COG1596	polysaccharide export
HW369_RS03635	COG2131	deaminase
HW369_RS03640	COG0658	competence protein
HW369_RS03640	COG2333	competence protein COMEC
HW369_RS03650	COG1466	dna polymerase III delta subunit
HW369_RS03655	COG0268	Binds directly to 16S ribosomal RNA
HW369_RS03660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HW369_RS03670	COG0481	GTPase activity
HW369_RS03675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW369_RS03680	COG1420	regulation of RNA biosynthetic process
HW369_RS03685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW369_RS03700	COG2264	protein methyltransferase activity
HW369_RS03705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW369_RS03710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW369_RS03720	COG1610	YqeY-like protein
HW369_RS03725	COG1030	water channel activity
HW369_RS03750	COG1702	phosphate starvation-inducible protein PhoH
HW369_RS03755	COG1480	7TM receptor with intracellular HD hydrolase
HW369_RS03765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW369_RS03770	COG0295	cytidine deaminase activity
HW369_RS03775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW369_RS03790	COG0517	IMP dehydrogenase activity
HW369_RS03795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW369_RS03800	COG1671	Belongs to the UPF0178 family
HW369_RS03805	COG0358	DNA primase activity
HW369_RS03810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW369_RS03815	COG1960	acyl-CoA dehydrogenase activity
HW369_RS03820	COG2010	Cytochrome c
HW369_RS03825	COG2384	SAM-dependent methyltransferase
HW369_RS03830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW369_RS03835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW369_RS03845	COG0513	Belongs to the DEAD box helicase family
HW369_RS03850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HW369_RS03860	COG1121	(ABC) transporter
HW369_RS03865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW369_RS03870	COG0735	belongs to the Fur family
HW369_RS03875	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HW369_RS03880	COG4709	membrane
HW369_RS03885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW369_RS03890	COG1388	LysM domain
HW369_RS03895	COG2814	Major facilitator Superfamily
HW369_RS03905	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW369_RS03910	COG2839	Protein conserved in bacteria
HW369_RS03945	COG0477	Major facilitator Superfamily
HW369_RS03950	COG0768	penicillin binding
HW369_RS03960	COG0704	Plays a role in the regulation of phosphate uptake
HW369_RS03975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HW369_RS03985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW369_RS04000	COG0457	Tetratricopeptide repeat
HW369_RS04000	COG0705	Rhomboid family
HW369_RS04005	COG4483	Protein conserved in bacteria
HW369_RS04010	COG1940	carbohydrate kinase activity
HW369_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS04035	COG1393	Belongs to the ArsC family
HW369_RS04040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW369_RS04045	COG1459	type II secretion system
HW369_RS04050	COG4537	Required for transformation and DNA binding
HW369_RS04055	COG4970	Tfp pilus assembly protein FimT
HW369_RS04085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW369_RS04090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW369_RS04095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW369_RS04105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW369_RS04110	COG0095	Lipoate-protein ligase
HW369_RS04120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW369_RS04125	COG1321	iron dependent repressor
HW369_RS04130	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW369_RS04140	COG3872	metal-dependent enzyme
HW369_RS04150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HW369_RS04155	COG0006	proline dipeptidase activity
HW369_RS04160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW369_RS04170	COG3854	ATPases associated with a variety of cellular activities
HW369_RS04210	COG0511	ligase activity, forming carbon-carbon bonds
HW369_RS04215	COG0439	Biotin carboxylase
HW369_RS04220	COG1302	Protein conserved in bacteria
HW369_RS04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW369_RS04235	COG1722	exodeoxyribonuclease VII activity
HW369_RS04250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW369_RS04260	COG0497	DNA recombination
HW369_RS04265	COG0750	zinc metalloprotease
HW369_RS04270	COG0745	RESPONSE REGULATOR receiver
HW369_RS04275	COG3104	oligopeptide transport
HW369_RS04280	COG3093	addiction module antidote protein HigA
HW369_RS04285	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS04295	COG3829	transcription factor binding
HW369_RS04295	COG3290	protein histidine kinase activity
HW369_RS04300	COG0280	phosphate acetyltransferase
HW369_RS04315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW369_RS04320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW369_RS04325	COG0022	dehydrogenase e1 component
HW369_RS04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW369_RS04335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS04335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS04340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS04340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW369_RS04345	COG1703	isobutyryl-CoA mutase activity
HW369_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW369_RS04360	COG0765	amino acid transport
HW369_RS04365	COG1126	abc transporter atp-binding protein
HW369_RS04370	COG4129	membrane
HW369_RS04375	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS04390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW369_RS04395	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW369_RS04400	COG0493	'glutamate synthase
HW369_RS04405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW369_RS04405	COG0167	dihydroorotate dehydrogenase activity
HW369_RS04425	COG2508	Transcriptional regulator
HW369_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS04435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW369_RS04445	COG1902	pentaerythritol trinitrate reductase activity
HW369_RS04450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW369_RS04455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS04460	COG0300	oxidoreductase activity
HW369_RS04475	COG1073	alpha beta
HW369_RS04480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW369_RS04490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW369_RS04495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW369_RS04505	COG0667	Aldo Keto reductase
HW369_RS04515	COG0494	nUDIX hydrolase
HW369_RS04520	COG1300	Membrane
HW369_RS04525	COG0735	belongs to the Fur family
HW369_RS04535	COG4974	Belongs to the 'phage' integrase family
HW369_RS04550	COG1686	Belongs to the peptidase S11 family
HW369_RS04585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW369_RS04600	COG0697	spore germination
HW369_RS04610	COG4086	secreted protein
HW369_RS04615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW369_RS04625	COG1547	Domain of unknown function (DUF309)
HW369_RS04635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW369_RS04640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW369_RS04645	COG1686	Belongs to the peptidase S11 family
HW369_RS04650	COG2715	membrane protein required for spore maturation
HW369_RS04655	COG0700	Nucleoside recognition
HW369_RS04660	COG1187	pseudouridine synthase activity
HW369_RS04665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS04670	COG1333	cytochrome c biogenesis protein
HW369_RS04675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW369_RS04680	COG0745	RESPONSE REGULATOR receiver
HW369_RS04685	COG5002	protein histidine kinase activity
HW369_RS04690	COG0739	heme binding
HW369_RS04695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW369_RS04700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HW369_RS04705	COG1141	Ferredoxin
HW369_RS04715	COG0514	ATP-dependent DNA helicase (RecQ)
HW369_RS04720	COG1266	CAAX protease self-immunity
HW369_RS04735	COG1408	metallophosphoesterase
HW369_RS04740	COG0789	Transcriptional regulator
HW369_RS04745	COG4862	establishment of competence for transformation
HW369_RS04750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW369_RS04755	COG0492	ferredoxin-NADP+ reductase activity
HW369_RS04760	COG0252	asparaginase activity
HW369_RS04765	COG2339	peptidase activity
HW369_RS04770	COG3773	Cell wall hydrolase
HW369_RS04770	COG3409	Peptidoglycan-binding domain 1 protein
HW369_RS04775	COG2959	enzyme of heme biosynthesis
HW369_RS04790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW369_RS04800	COG0539	negative regulation of cytoplasmic translation
HW369_RS04805	COG1304	FMN binding
HW369_RS04810	COG2271	Major facilitator Superfamily
HW369_RS04845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW369_RS04850	COG0776	regulation of translation
HW369_RS04855	COG0302	gtp cyclohydrolase
HW369_RS04865	COG0142	geranyltranstransferase activity
HW369_RS04870	COG2226	methyltransferase
HW369_RS04875	COG0142	geranyltranstransferase activity
HW369_RS04880	COG0105	UTP biosynthetic process
HW369_RS04885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW369_RS04890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW369_RS04895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW369_RS04905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW369_RS04910	COG0134	indole-3-glycerol-phosphate synthase activity
HW369_RS04915	COG0135	phosphoribosylanthranilate isomerase activity
HW369_RS04925	COG0159	tryptophan synthase activity
HW369_RS04930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW369_RS04935	COG0287	Prephenate dehydrogenase
HW369_RS04940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW369_RS04945	COG0457	Tetratricopeptide repeat
HW369_RS04950	COG5582	Belongs to the UPF0302 family
HW369_RS04965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW369_RS04975	COG4347	Protein of unknown function (DUF1405)
HW369_RS04995	COG3679	Belongs to the UPF0342 family
HW369_RS05005	COG4471	UPF0298 protein
HW369_RS05015	COG0742	ribosomal rna small subunit methyltransferase
HW369_RS05020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW369_RS05025	COG3314	Sporulation integral membrane protein YlbJ
HW369_RS05030	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW369_RS05035	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW369_RS05040	COG1323	Belongs to the UPF0348 family
HW369_RS05045	COG1399	metal-binding, possibly nucleic acid-binding protein
HW369_RS05050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW369_RS05055	COG1024	Enoyl-CoA hydratase
HW369_RS05065	COG0454	-acetyltransferase
HW369_RS05070	COG0439	Biotin carboxylase
HW369_RS05075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW369_RS05080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW369_RS05085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW369_RS05095	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HW369_RS05105	COG4839	cell division protein FtsL
HW369_RS05110	COG0768	penicillin binding
HW369_RS05115	COG0768	penicillin binding
HW369_RS05120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW369_RS05125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW369_RS05130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW369_RS05135	COG0772	Belongs to the SEDS family
HW369_RS05140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW369_RS05145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW369_RS05150	COG0849	cell division
HW369_RS05155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW369_RS05165	COG1191	sigma factor activity
HW369_RS05170	COG1191	sigma factor activity
HW369_RS05175	COG1873	PFAM PRC-barrel domain
HW369_RS05185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW369_RS05190	COG1799	cell septum assembly
HW369_RS05195	COG0762	integral membrane protein
HW369_RS05200	COG2302	S4 RNA-binding domain
HW369_RS05205	COG3599	regulation of cell shape
HW369_RS05220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW369_RS05225	COG0564	pseudouridine synthase activity
HW369_RS05230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW369_RS05240	COG0540	Belongs to the ATCase OTCase family
HW369_RS05245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW369_RS05260	COG0543	2 iron, 2 sulfur cluster binding
HW369_RS05275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW369_RS05285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW369_RS05290	COG1561	YicC-like family, N-terminal region
HW369_RS05295	COG2052	Domain of unknown function (DUF370)
HW369_RS05300	COG0194	GDP metabolic process
HW369_RS05305	COG1758	RNA polymerase activity
HW369_RS05310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW369_RS05315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW369_RS05325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW369_RS05330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW369_RS05330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW369_RS05340	COG0631	protein serine/threonine phosphatase activity
HW369_RS05345	COG2815	serine threonine protein kinase
HW369_RS05345	COG0515	serine threonine protein kinase
HW369_RS05350	COG1162	GTPase activity
HW369_RS05355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW369_RS05360	COG1564	THIamine pyrophosphokinase
HW369_RS05370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW369_RS05375	COG1302	Protein conserved in bacteria
HW369_RS05380	COG1461	Dihydroxyacetone kinase
HW369_RS05390	COG1760	l-serine dehydratase
HW369_RS05395	COG1760	l-serine dehydratase
HW369_RS05400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW369_RS05405	COG1349	DNA-binding transcription factor activity
HW369_RS05410	COG0416	fatty acid biosynthetic process
HW369_RS05415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW369_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS05430	COG0571	ribonuclease III activity
HW369_RS05435	COG1196	nuclear chromosome segregation
HW369_RS05440	COG0552	protein localization to endoplasmic reticulum
HW369_RS05450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW369_RS05455	COG0228	four-way junction DNA binding
HW369_RS05460	COG1837	Belongs to the UPF0109 family
HW369_RS05470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW369_RS05480	COG0335	large ribosomal subunit rRNA binding
HW369_RS05500	COG0045	succinate-CoA ligase (ADP-forming) activity
HW369_RS05505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW369_RS05510	COG0758	DNA mediated transformation
HW369_RS05515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW369_RS05520	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW369_RS05525	COG4974	Belongs to the 'phage' integrase family
HW369_RS05535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HW369_RS05540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW369_RS05545	COG1815	bacterial-type flagellum-dependent cell motility
HW369_RS05550	COG1558	bacterial-type flagellum-dependent cell motility
HW369_RS05555	COG1677	Flagellar hook-basal body complex protein FliE
HW369_RS05560	COG1766	The M ring may be actively involved in energy transduction
HW369_RS05565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW369_RS05570	COG1317	bacterial-type flagellum organization
HW369_RS05575	COG1157	protein secretion by the type III secretion system
HW369_RS05580	COG2882	bacterial-type flagellum organization
HW369_RS05595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW369_RS05600	COG4786	Flagellar basal body rod
HW369_RS05605	COG1582	Flagellar protein (FlbD)
HW369_RS05615	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW369_RS05620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW369_RS05620	COG1776	CheC inhibitor of MCP methylation
HW369_RS05625	COG2201	protein-glutamate methylesterase activity
HW369_RS05630	COG3190	flagellar
HW369_RS05635	COG1338	Plays a role in the flagellum-specific transport system
HW369_RS05640	COG1987	bacterial-type flagellum assembly
HW369_RS05645	COG1684	flagellar biosynthetic protein fliR
HW369_RS05650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW369_RS05655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW369_RS05660	COG1419	protein localization to endoplasmic reticulum
HW369_RS05665	COG0455	bacterial-type flagellum organization
HW369_RS05670	COG2201	protein-glutamate methylesterase activity
HW369_RS05675	COG0643	Histidine kinase
HW369_RS05675	COG2198	Histidine kinase
HW369_RS05680	COG0835	chemotaxis
HW369_RS05685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HW369_RS05690	COG1191	sigma factor activity
HW369_RS05705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW369_RS05715	COG0233	cytoplasmic translational termination
HW369_RS05725	COG4589	Belongs to the CDS family
HW369_RS05735	COG0750	zinc metalloprotease
HW369_RS05740	COG0442	prolyl-tRNA aminoacylation
HW369_RS05745	COG2176	DNA-directed DNA polymerase activity
HW369_RS05750	COG0779	Required for maturation of 30S ribosomal subunits
HW369_RS05755	COG0195	Participates in both transcription termination and antitermination
HW369_RS05760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HW369_RS05765	COG1358	cellular component organization or biogenesis
HW369_RS05775	COG1550	Protein conserved in bacteria
HW369_RS05780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW369_RS05790	COG0196	riboflavin kinase activity
HW369_RS05795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW369_RS05800	COG1185	polyribonucleotide nucleotidyltransferase activity
HW369_RS05805	COG0726	polysaccharide deacetylase
HW369_RS05810	COG0612	Peptidase, M16
HW369_RS05815	COG1873	PFAM PRC-barrel domain
HW369_RS05820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW369_RS05825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW369_RS05830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW369_RS05835	COG0527	aspartate kinase activity
HW369_RS05845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW369_RS05850	COG0740	serine-type endopeptidase activity
HW369_RS05860	COG4980	gas vesicle protein
HW369_RS05860	COG1674	ftsk spoiiie
HW369_RS05865	COG2188	Transcriptional regulator
HW369_RS05870	COG1744	ABC transporter substrate-binding protein PnrA-like
HW369_RS05875	COG3845	ABC transporter
HW369_RS05880	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW369_RS05885	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW369_RS05890	COG0612	Peptidase, M16
HW369_RS05895	COG0612	Peptidase, M16
HW369_RS05900	COG0300	oxidoreductase activity
HW369_RS05915	COG1426	Protein conserved in bacteria
HW369_RS05920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW369_RS05925	COG1546	Belongs to the CinA family
HW369_RS05925	COG1058	Belongs to the CinA family
HW369_RS05930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW369_RS05940	COG1692	metallophosphoesterase
HW369_RS05945	COG2359	stage V sporulation protein S
HW369_RS05960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW369_RS05960	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW369_RS05965	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW369_RS05970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW369_RS05975	COG4550	Control of competence regulator ComK, YlbF/YmcA
HW369_RS05985	COG0531	amino acid
HW369_RS05990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW369_RS06000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW369_RS06010	COG0464	growth
HW369_RS06015	COG2860	membrane
HW369_RS06020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW369_RS06025	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HW369_RS06030	COG0789	Transcriptional regulator
HW369_RS06035	COG0174	glutamine synthetase
HW369_RS06045	COG0531	amino acid
HW369_RS06050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW369_RS06055	COG0463	Glycosyl transferase, family 2
HW369_RS06090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW369_RS06095	COG4224	UPF0291 protein
HW369_RS06115	COG1132	(ABC) transporter
HW369_RS06120	COG1132	(ABC) transporter
HW369_RS06130	COG0785	Cytochrome C biogenesis protein
HW369_RS06135	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HW369_RS06140	COG4846	Membrane protein involved in cytochrome C biogenesis
HW369_RS06150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW369_RS06160	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS06180	COG3852	Histidine kinase
HW369_RS06185	COG0415	Belongs to the DNA photolyase family
HW369_RS06205	COG0076	glutamate decarboxylase activity
HW369_RS06235	COG0788	formyltetrahydrofolate deformylase activity
HW369_RS06240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW369_RS06245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW369_RS06255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW369_RS06265	COG1307	EDD domain protein, DegV family
HW369_RS06275	COG1999	signal sequence binding
HW369_RS06280	COG2755	lipolytic protein G-D-S-L family
HW369_RS06310	COG4191	Histidine kinase
HW369_RS06320	COG1301	dicarboxylic acid transport
HW369_RS06325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW369_RS06330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW369_RS06335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW369_RS06340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW369_RS06345	COG0456	acetyltransferase
HW369_RS06350	COG1509	lysine 2,3-aminomutase activity
HW369_RS06365	COG3594	Acyltransferase
HW369_RS06370	COG4479	Belongs to the UPF0346 family
HW369_RS06395	COG2815	serine threonine protein kinase
HW369_RS06395	COG0515	serine threonine protein kinase
HW369_RS06400	COG4326	sporulation control protein
HW369_RS06405	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS06420	COG0813	purine-nucleoside phosphorylase activity
HW369_RS06425	COG0659	secondary active sulfate transmembrane transporter activity
HW369_RS06430	COG0772	Belongs to the SEDS family
HW369_RS06445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW369_RS06455	COG2190	(PTS) system
HW369_RS06460	COG3711	transcriptional antiterminator
HW369_RS06465	COG1263	PTS System
HW369_RS06465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS06470	COG0706	membrane insertase activity
HW369_RS06485	COG1121	(ABC) transporter
HW369_RS06495	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS06510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS06525	COG1131	(ABC) transporter
HW369_RS06550	COG0814	amino acid
HW369_RS06555	COG0697	spore germination
HW369_RS06560	COG0432	Pfam Uncharacterised protein family UPF0047
HW369_RS06570	COG1388	LysM domain
HW369_RS06570	COG0791	NLP P60 protein
HW369_RS06575	COG0205	6-phosphofructokinase activity
HW369_RS06585	COG0589	response to stress
HW369_RS06590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW369_RS06600	COG1253	flavin adenine dinucleotide binding
HW369_RS06605	COG2340	Cysteine-rich secretory protein family
HW369_RS06610	COG0668	transmembrane transport
HW369_RS06615	COG0385	Bile acid
HW369_RS06625	COG1115	amino acid carrier protein
HW369_RS06630	COG1280	lysine exporter protein (LysE YggA)
HW369_RS06650	COG2514	catechol 2,3-dioxygenase activity
HW369_RS06655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW369_RS06675	COG0463	Glycosyl transferase, family 2
HW369_RS06705	COG1113	amino acid transport
HW369_RS06720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS06730	COG4195	phage-related replication protein
HW369_RS06740	COG1285	pathogenesis
HW369_RS06745	COG2910	NAD(P)H-binding
HW369_RS06755	COG0730	response to heat
HW369_RS06760	COG0583	DNA-binding transcription factor activity
HW369_RS06770	COG1309	transcriptional regulator
HW369_RS06775	COG5505	Protein of unknown function (DUF819)
HW369_RS06780	COG1113	amino acid transport
HW369_RS06795	COG1902	pentaerythritol trinitrate reductase activity
HW369_RS06800	COG0697	spore germination
HW369_RS06810	COG1368	sulfuric ester hydrolase activity
HW369_RS06830	COG0753	catalase activity
HW369_RS06845	COG1301	dicarboxylic acid transport
HW369_RS06850	COG0730	response to heat
HW369_RS06855	COG2205	protein histidine kinase activity
HW369_RS06860	COG1609	Transcriptional regulator
HW369_RS06870	COG1653	transport
HW369_RS06880	COG0395	ABC-type sugar transport system, permease component
HW369_RS06890	COG2814	Major facilitator Superfamily
HW369_RS06905	COG0517	IMP dehydrogenase activity
HW369_RS06905	COG1125	glycine betaine transport
HW369_RS06910	COG1174	glycine betaine transport
HW369_RS06915	COG5522	Integral membrane protein (intg_mem_TP0381)
HW369_RS06920	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW369_RS06940	COG0006	proline dipeptidase activity
HW369_RS06950	COG0697	spore germination
HW369_RS06955	COG1802	Transcriptional regulator
HW369_RS06960	COG1607	acyl-coa hydrolase
HW369_RS06965	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HW369_RS06970	COG2205	protein histidine kinase activity
HW369_RS06970	COG2770	Histidine kinase
HW369_RS06975	COG0745	RESPONSE REGULATOR receiver
HW369_RS06980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW369_RS06990	COG1522	sequence-specific DNA binding
HW369_RS07000	COG0569	domain protein
HW369_RS07005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW369_RS07025	COG0405	Gamma-glutamyltransferase
HW369_RS07035	COG0833	amino acid
HW369_RS07050	COG0697	spore germination
HW369_RS07060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS07065	COG0726	polysaccharide deacetylase
HW369_RS07070	COG1595	DNA-templated transcription, initiation
HW369_RS07080	COG1846	Transcriptional regulator
HW369_RS07085	COG0840	transmembrane signaling receptor activity
HW369_RS07090	COG1388	LysM domain
HW369_RS07090	COG0791	NLP P60 protein
HW369_RS07105	COG0463	Glycosyl transferase, family 2
HW369_RS07120	COG2259	Doxx family
HW369_RS07125	COG2124	cytochrome p450
HW369_RS07130	COG1733	regulation of RNA biosynthetic process
HW369_RS07135	COG1024	Enoyl-CoA hydratase
HW369_RS07140	COG3973	AAA domain
HW369_RS07155	COG3209	COG3209 Rhs family protein
HW369_RS07160	COG1937	Protein conserved in bacteria
HW369_RS07165	COG1289	transmembrane transporter activity
HW369_RS07180	COG0642	Histidine kinase
HW369_RS07190	COG1136	(ABC) transporter
HW369_RS07195	COG0577	efflux transmembrane transporter activity
HW369_RS07200	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW369_RS07225	COG4980	gas vesicle protein
HW369_RS07230	COG1621	beta-fructofuranosidase activity
HW369_RS07255	COG0789	Transcriptional regulator
HW369_RS07265	COG0667	Aldo Keto reductase
HW369_RS07270	COG0789	Transcriptional regulator
HW369_RS07295	COG1247	-acetyltransferase
HW369_RS07325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW369_RS07330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HW369_RS07345	COG4640	response to antibiotic
HW369_RS07385	COG3300	MHYT domain
HW369_RS07385	COG5001	Diguanylate cyclase
HW369_RS07390	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS07410	COG3878	Protein conserved in bacteria
HW369_RS07415	COG0506	proline dehydrogenase activity
HW369_RS07420	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS07425	COG1113	amino acid transport
HW369_RS07430	COG1113	amino acid transport
HW369_RS07445	COG1278	Cold shock
HW369_RS07465	COG1846	Transcriptional regulator
HW369_RS07470	COG2814	Major facilitator Superfamily
HW369_RS07475	COG0791	NLP P60 protein
HW369_RS07495	COG0670	Belongs to the BI1 family
HW369_RS07515	COG2851	Citrate transporter
HW369_RS07520	COG0583	DNA-binding transcription factor activity
HW369_RS07525	COG2828	Protein conserved in bacteria
HW369_RS07545	COG2244	polysaccharide biosynthetic process
HW369_RS07565	COG3845	ABC transporter
HW369_RS07570	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW369_RS07575	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW369_RS07580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW369_RS07585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW369_RS07595	COG0303	'Molybdopterin
HW369_RS07610	COG0667	Aldo Keto reductase
HW369_RS07615	COG0789	Transcriptional regulator
HW369_RS07620	COG4221	oxidoreductase activity
HW369_RS07630	COG3339	Conserved Protein
HW369_RS07635	COG1971	Probably functions as a manganese efflux pump
HW369_RS07755	COG3620	sequence-specific DNA binding
HW369_RS07765	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW369_RS07775	COG2814	Major facilitator Superfamily
HW369_RS07785	COG0583	DNA-binding transcription factor activity
HW369_RS07795	COG1695	Transcriptional regulator
HW369_RS07810	COG0686	Belongs to the AlaDH PNT family
HW369_RS07825	COG0252	asparaginase activity
HW369_RS07845	COG0156	8-amino-7-oxononanoate synthase activity
HW369_RS07850	COG1266	CAAX protease self-immunity
HW369_RS07865	COG1309	transcriptional regulator
HW369_RS07870	COG0577	efflux transmembrane transporter activity
HW369_RS07875	COG1136	(ABC) transporter
HW369_RS07895	COG0583	DNA-binding transcription factor activity
HW369_RS07910	COG1609	Transcriptional regulator
HW369_RS07915	COG0366	Alpha amylase catalytic
HW369_RS07920	COG1621	beta-fructofuranosidase activity
HW369_RS07925	COG4572	Cation transport regulator
HW369_RS07930	COG1309	transcriptional regulator
HW369_RS07935	COG0477	Major facilitator Superfamily
HW369_RS07950	COG0477	Major facilitator Superfamily
HW369_RS07965	COG2259	Doxx family
HW369_RS07970	COG0346	lactoylglutathione lyase activity
HW369_RS07980	COG1335	isochorismatase
HW369_RS07990	COG2267	carboxylic ester hydrolase activity
HW369_RS08015	COG0456	acetyltransferase
HW369_RS08015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW369_RS08025	COG1396	sequence-specific DNA binding
HW369_RS08045	COG2311	Membrane
HW369_RS08055	COG3708	Transcriptional regulator
HW369_RS08055	COG2207	Transcriptional regulator
HW369_RS08060	COG2211	Major facilitator Superfamily
HW369_RS08065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW369_RS08075	COG1501	Belongs to the glycosyl hydrolase 31 family
HW369_RS08085	COG2188	Transcriptional regulator
HW369_RS08090	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS08100	COG0523	cobalamin synthesis protein
HW369_RS08105	COG0717	Belongs to the dCTP deaminase family
HW369_RS08110	COG0523	cobalamin synthesis protein
HW369_RS08140	COG1414	Transcriptional regulator
HW369_RS08145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS08155	COG4948	Mandelate Racemase Muconate Lactonizing
HW369_RS08160	COG2271	Major facilitator Superfamily
HW369_RS08170	COG0693	protein deglycase activity
HW369_RS08175	COG1335	isochorismatase
HW369_RS08185	COG0583	DNA-binding transcription factor activity
HW369_RS08190	COG2807	transmembrane transport
HW369_RS08195	COG0702	epimerase
HW369_RS08205	COG3964	amidohydrolase
HW369_RS08225	COG2188	Transcriptional regulator
HW369_RS08235	COG1070	Carbohydrate kinase
HW369_RS08240	COG0434	BtpA family
HW369_RS08245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS08255	COG0697	spore germination
HW369_RS08275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW369_RS08300	COG4282	regulation of fungal-type cell wall biogenesis
HW369_RS08390	COG1132	(ABC) transporter
HW369_RS08405	COG1131	(ABC) transporter
HW369_RS08420	COG2002	toxin-antitoxin pair type II binding
HW369_RS08425	COG0745	RESPONSE REGULATOR receiver
HW369_RS08430	COG2205	protein histidine kinase activity
HW369_RS08435	COG2095	MarC family integral membrane protein
HW369_RS08445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW369_RS08450	COG2258	MOSC domain
HW369_RS08455	COG0791	NLP P60 protein
HW369_RS08455	COG1388	LysM domain
HW369_RS08460	COG0697	spore germination
HW369_RS08495	COG1846	Transcriptional regulator
HW369_RS08525	COG1918	ferrous iron import across plasma membrane
HW369_RS08525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW369_RS08530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW369_RS08535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW369_RS08560	COG1078	dGTPase activity
HW369_RS08565	COG1609	Transcriptional regulator
HW369_RS08580	COG2160	L-arabinose isomerase activity
HW369_RS08585	COG2814	Major facilitator Superfamily
HW369_RS08600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW369_RS08610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW369_RS08610	COG3153	acetyltransferase
HW369_RS08670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW369_RS08680	COG0561	phosphatase activity
HW369_RS08685	COG1349	DNA-binding transcription factor activity
HW369_RS08695	COG3619	membrane
HW369_RS08700	COG1247	-acetyltransferase
HW369_RS08715	COG2186	Transcriptional regulator
HW369_RS08745	COG0454	-acetyltransferase
HW369_RS08750	COG4335	DNA alkylation repair
HW369_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS08785	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS08790	COG0598	Magnesium transport protein CorA
HW369_RS08810	COG1876	peptidase activity
HW369_RS08815	COG5001	Diguanylate cyclase
HW369_RS08820	COG3290	protein histidine kinase activity
HW369_RS08820	COG0840	transmembrane signaling receptor activity
HW369_RS08830	COG1278	Cold shock
HW369_RS08835	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS08860	COG0662	Cupin 2, conserved barrel domain protein
HW369_RS08875	COG0789	Transcriptional regulator
HW369_RS08880	COG1064	alcohol dehydrogenase
HW369_RS08895	COG2814	Major facilitator Superfamily
HW369_RS08900	COG1082	Xylose isomerase domain protein TIM barrel
HW369_RS08905	COG0191	fructose-bisphosphate aldolase activity
HW369_RS08910	COG1349	DNA-binding transcription factor activity
HW369_RS08915	COG3962	Belongs to the TPP enzyme family
HW369_RS08920	COG3718	enzyme involved in inositol metabolism
HW369_RS08940	COG0673	inositol 2-dehydrogenase activity
HW369_RS08945	COG1082	Xylose isomerase domain protein TIM barrel
HW369_RS08950	COG1609	Transcriptional regulator
HW369_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS08995	COG0659	secondary active sulfate transmembrane transporter activity
HW369_RS09005	COG3655	Transcriptional regulator
HW369_RS09040	COG1131	(ABC) transporter
HW369_RS09055	COG0745	RESPONSE REGULATOR receiver
HW369_RS09060	COG5002	protein histidine kinase activity
HW369_RS09075	COG2329	Antibiotic biosynthesis monooxygenase
HW369_RS09090	COG2312	Erythromycin esterase
HW369_RS09135	COG0772	Belongs to the SEDS family
HW369_RS09180	COG1063	alcohol dehydrogenase
HW369_RS09185	COG0583	DNA-binding transcription factor activity
HW369_RS09195	COG0659	secondary active sulfate transmembrane transporter activity
HW369_RS09225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW369_RS09235	COG1278	Cold shock
HW369_RS09245	COG1278	Cold shock
HW369_RS09250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS09255	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HW369_RS09265	COG4807	Protein conserved in bacteria
HW369_RS09305	COG2808	Putative FMN-binding domain
HW369_RS09310	COG0346	lactoylglutathione lyase activity
HW369_RS09320	COG2304	oxidoreductase activity
HW369_RS09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS09340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW369_RS09345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW369_RS09350	COG1733	regulation of RNA biosynthetic process
HW369_RS09365	COG0726	polysaccharide deacetylase
HW369_RS09370	COG1704	LemA family
HW369_RS09390	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS09395	COG0778	Nitroreductase
HW369_RS09415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW369_RS09425	COG3711	transcriptional antiterminator
HW369_RS09430	COG1263	PTS System
HW369_RS09430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS09430	COG2190	(PTS) system
HW369_RS09435	COG2723	6-phospho-beta-galactosidase activity
HW369_RS09440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW369_RS09450	COG0346	lactoylglutathione lyase activity
HW369_RS09455	COG0583	DNA-binding transcription factor activity
HW369_RS09465	COG3695	enzyme binding
HW369_RS09475	COG1280	lysine exporter protein (LysE YggA)
HW369_RS09500	COG2723	6-phospho-beta-galactosidase activity
HW369_RS09505	COG2188	Transcriptional regulator
HW369_RS09525	COG0583	DNA-binding transcription factor activity
HW369_RS09550	COG1937	Protein conserved in bacteria
HW369_RS09555	COG0425	Belongs to the sulfur carrier protein TusA family
HW369_RS09560	COG2210	Belongs to the sulfur carrier protein TusA family
HW369_RS09565	COG1054	Belongs to the UPF0176 family
HW369_RS09575	COG0425	Belongs to the sulfur carrier protein TusA family
HW369_RS09575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW369_RS09580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW369_RS09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS09585	COG0425	Belongs to the sulfur carrier protein TusA family
HW369_RS09590	COG0730	response to heat
HW369_RS09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS09615	COG0412	Dienelactone hydrolase
HW369_RS09625	COG0577	efflux transmembrane transporter activity
HW369_RS09630	COG1136	(ABC) transporter
HW369_RS09635	COG0642	Histidine kinase
HW369_RS09640	COG0745	RESPONSE REGULATOR receiver
HW369_RS09645	COG1063	alcohol dehydrogenase
HW369_RS09670	COG1073	alpha beta
HW369_RS09705	COG2824	Alkylphosphonate utilization operon protein PhnA
HW369_RS09710	COG1301	dicarboxylic acid transport
HW369_RS09720	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW369_RS09795	COG2207	Transcriptional regulator
HW369_RS09795	COG1917	Cupin 2, conserved barrel domain protein
HW369_RS09800	COG0697	spore germination
HW369_RS09810	COG4989	oxidoreductase activity
HW369_RS09830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS09835	COG5002	protein histidine kinase activity
HW369_RS09860	COG3850	Histidine kinase
HW369_RS09860	COG5002	protein histidine kinase activity
HW369_RS09865	COG0577	efflux transmembrane transporter activity
HW369_RS09870	COG1136	(ABC) transporter
HW369_RS09880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW369_RS09885	COG0346	lactoylglutathione lyase activity
HW369_RS09915	COG1819	glycosyl
HW369_RS09935	COG3209	COG3209 Rhs family protein
HW369_RS09950	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS09955	COG2197	response regulator
HW369_RS09960	COG2203	Gaf domain
HW369_RS09960	COG4585	Histidine kinase
HW369_RS09965	COG2207	Transcriptional regulator
HW369_RS09965	COG1917	Cupin 2, conserved barrel domain protein
HW369_RS09970	COG1280	lysine exporter protein (LysE YggA)
HW369_RS09990	COG3546	catalase activity
HW369_RS10015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW369_RS10020	COG3773	Cell wall hydrolase
HW369_RS10080	COG1959	2 iron, 2 sulfur cluster binding
HW369_RS10085	COG1609	Transcriptional regulator
HW369_RS10090	COG0861	Integral membrane protein TerC family
HW369_RS10095	COG1396	sequence-specific DNA binding
HW369_RS10100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW369_RS10110	COG1193	negative regulation of DNA recombination
HW369_RS10135	COG0681	Belongs to the peptidase S26 family
HW369_RS10140	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW369_RS10155	COG3773	Cell wall hydrolase
HW369_RS10160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS10165	COG4605	iron ion homeostasis
HW369_RS10170	COG4604	ABC transporter, ATP-binding protein
HW369_RS10175	COG4607	ABC-type enterochelin transport system periplasmic component
HW369_RS10205	COG2910	NAD(P)H-binding
HW369_RS10225	COG1278	Cold shock
HW369_RS10230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW369_RS10235	COG2076	Multidrug Resistance protein
HW369_RS10240	COG1309	transcriptional regulator
HW369_RS10250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HW369_RS10290	COG0501	Belongs to the peptidase M48B family
HW369_RS10300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW369_RS10315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS10340	COG2130	NADP-dependent
HW369_RS10355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS10360	COG0730	response to heat
HW369_RS10365	COG3764	Sortase (surface protein transpeptidase)
HW369_RS10380	COG0531	amino acid
HW369_RS10385	COG1280	lysine exporter protein (LysE YggA)
HW369_RS10450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW369_RS10460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HW369_RS10480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS10485	COG1316	TRANSCRIPTIONal
HW369_RS10495	COG1228	amidohydrolase
HW369_RS10505	COG2814	Major facilitator Superfamily
HW369_RS10520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW369_RS10530	COG1902	pentaerythritol trinitrate reductase activity
HW369_RS10555	COG1819	glycosyl
HW369_RS10590	COG0456	acetyltransferase
HW369_RS10590	COG1214	PFAM Peptidase M22, glycoprotease
HW369_RS10595	COG0789	Transcriptional regulator
HW369_RS10600	COG1846	Transcriptional regulator
HW369_RS10605	COG0477	Major facilitator Superfamily
HW369_RS10620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW369_RS10625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW369_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS10640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS10650	COG2746	aminoglycoside 3-N-acetyltransferase activity
HW369_RS10655	COG0281	malic enzyme
HW369_RS10675	COG1959	2 iron, 2 sulfur cluster binding
HW369_RS10680	COG0531	amino acid
HW369_RS10700	COG0640	Transcriptional regulator
HW369_RS10720	COG1396	sequence-specific DNA binding
HW369_RS10725	COG0252	asparaginase activity
HW369_RS10730	COG1027	Aspartate ammonia-lyase
HW369_RS10745	COG0740	serine-type endopeptidase activity
HW369_RS10760	COG2261	transglycosylase associated protein
HW369_RS10765	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS10795	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS10800	COG2202	Pas domain
HW369_RS10800	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS10820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS10825	COG0697	spore germination
HW369_RS10830	COG0583	DNA-binding transcription factor activity
HW369_RS10835	COG0372	Belongs to the citrate synthase family
HW369_RS10845	COG1597	lipid kinase activity
HW369_RS10850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS10855	COG2211	Major facilitator Superfamily
HW369_RS10870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS10875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HW369_RS10885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW369_RS10890	COG2318	DinB family
HW369_RS10895	COG2002	toxin-antitoxin pair type II binding
HW369_RS10900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW369_RS10905	COG4991	sh3 domain protein
HW369_RS10905	COG3103	Sh3 type 3 domain protein
HW369_RS10905	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS10910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW369_RS10925	COG0778	Nitroreductase
HW369_RS10935	COG0640	Transcriptional regulator
HW369_RS10965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HW369_RS10975	COG2205	protein histidine kinase activity
HW369_RS10990	COG1902	pentaerythritol trinitrate reductase activity
HW369_RS10995	COG0730	response to heat
HW369_RS11040	COG0733	neurotransmitter:sodium symporter activity
HW369_RS11050	COG0753	catalase activity
HW369_RS11055	COG0791	NLP P60 protein
HW369_RS11055	COG1388	LysM domain
HW369_RS11060	COG0011	TIGRFAM Protein of
HW369_RS11065	COG2508	Transcriptional regulator
HW369_RS11070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW369_RS11075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW369_RS11085	COG2059	Chromate
HW369_RS11090	COG2059	Chromate
HW369_RS11100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW369_RS11100	COG1605	Chorismate mutase
HW369_RS11110	COG0287	Prephenate dehydrogenase
HW369_RS11125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW369_RS11125	COG0723	plastoquinol--plastocyanin reductase activity
HW369_RS11140	COG0517	IMP dehydrogenase activity
HW369_RS11140	COG0516	GMP reductase activity
HW369_RS11155	COG1253	flavin adenine dinucleotide binding
HW369_RS11160	COG5577	PFAM Coat F domain
HW369_RS11170	COG0783	Belongs to the Dps family
HW369_RS11210	COG1132	(ABC) transporter
HW369_RS11230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS11235	COG0697	spore germination
HW369_RS11240	COG2244	polysaccharide biosynthetic process
HW369_RS11245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW369_RS11250	COG0400	carboxylic ester hydrolase activity
HW369_RS11260	COG0586	Pfam SNARE associated Golgi protein
HW369_RS11265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW369_RS11270	COG0778	Nitroreductase
HW369_RS11275	COG3583	domain protein
HW369_RS11275	COG3584	3D domain protein
HW369_RS11280	COG0791	NLP P60 protein
HW369_RS11280	COG1388	LysM domain
HW369_RS11285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW369_RS11290	COG0831	urea catabolic process
HW369_RS11305	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HW369_RS11345	COG0463	Glycosyl transferase, family 2
HW369_RS11350	COG1233	COG1233 Phytoene dehydrogenase and related
HW369_RS11365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS11370	COG2271	Major facilitator Superfamily
HW369_RS11380	COG1609	Transcriptional regulator
HW369_RS11390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW369_RS11395	COG2404	hydrolase activity, acting on ester bonds
HW369_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS11410	COG0531	amino acid
HW369_RS11420	COG1492	cobalamin metabolic process
HW369_RS11425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS11430	COG4604	ABC transporter, ATP-binding protein
HW369_RS11465	COG1960	acyl-CoA dehydrogenase activity
HW369_RS11470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW369_RS11470	COG0456	acetyltransferase
HW369_RS11490	COG0596	Alpha beta hydrolase
HW369_RS11505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HW369_RS11510	COG0004	ammonium transporteR
HW369_RS11515	COG0347	Belongs to the P(II) protein family
HW369_RS11575	COG2311	Membrane
HW369_RS11585	COG1764	response to oxidative stress
HW369_RS11590	COG2814	Major facilitator Superfamily
HW369_RS11600	COG0567	Dehydrogenase, E1 component
HW369_RS11605	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW369_RS11625	COG0745	RESPONSE REGULATOR receiver
HW369_RS11630	COG5002	protein histidine kinase activity
HW369_RS11640	COG1876	peptidase activity
HW369_RS11645	COG2323	membrane
HW369_RS11655	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW369_RS11660	COG0598	Magnesium transport protein CorA
HW369_RS11665	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS11670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS11685	COG4682	membrane
HW369_RS11710	COG1595	DNA-templated transcription, initiation
HW369_RS11730	COG1131	(ABC) transporter
HW369_RS11735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW369_RS11760	COG1620	l-lactate permease
HW369_RS11765	COG0277	FAD linked oxidase domain protein
HW369_RS11770	COG0247	lactate metabolic process
HW369_RS11775	COG0277	FAD linked oxidase domain protein
HW369_RS11780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW369_RS11785	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW369_RS11790	COG1414	Transcriptional regulator
HW369_RS11795	COG2309	aminopeptidase activity
HW369_RS11830	COG0668	transmembrane transport
HW369_RS11845	COG0561	phosphatase activity
HW369_RS11850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW369_RS11855	COG0579	oxidoreductase
HW369_RS11865	COG1525	nuclease
HW369_RS11885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS11895	COG0747	negative chemotaxis
HW369_RS11900	COG0601	transmembrane transport
HW369_RS11905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW369_RS11915	COG4608	Belongs to the ABC transporter superfamily
HW369_RS11935	COG1253	flavin adenine dinucleotide binding
HW369_RS11940	COG0025	NhaP-type Na H and K H
HW369_RS11965	COG1063	alcohol dehydrogenase
HW369_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS12000	COG2211	Major facilitator Superfamily
HW369_RS12020	COG0583	DNA-binding transcription factor activity
HW369_RS12025	COG1979	alcohol dehydrogenase
HW369_RS12040	COG2391	methyltransferase activity
HW369_RS12085	COG2182	Extracellular solute-binding protein
HW369_RS12095	COG1742	UPF0060 membrane protein
HW369_RS12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS12105	COG0501	Belongs to the peptidase M48B family
HW369_RS12110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW369_RS12140	COG2390	Transcriptional regulator
HW369_RS12155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HW369_RS12160	COG0295	cytidine deaminase activity
HW369_RS12165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW369_RS12185	COG3152	Membrane
HW369_RS12190	COG3152	Membrane
HW369_RS12200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW369_RS12215	COG0492	ferredoxin-NADP+ reductase activity
HW369_RS12225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW369_RS12230	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS12245	COG1819	glycosyl
HW369_RS12260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS12295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS12300	COG1278	Cold shock
HW369_RS12335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW369_RS12380	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HW369_RS12385	COG5646	InterPro IPR014922
HW369_RS12475	COG3152	Membrane
HW369_RS12480	COG1454	alcohol dehydrogenase
HW369_RS12485	COG3835	regulator
HW369_RS12490	COG2610	gluconate transmembrane transporter activity
HW369_RS12495	COG1929	Belongs to the glycerate kinase type-1 family
HW369_RS12500	COG0596	Alpha beta hydrolase
HW369_RS12520	COG1609	Transcriptional regulator
HW369_RS12525	COG1653	transport
HW369_RS12530	COG1175	transmembrane transport
HW369_RS12535	COG0395	ABC-type sugar transport system, permease component
HW369_RS12540	COG1486	melibiose metabolic process
HW369_RS12545	COG0488	(ABC) transporter
HW369_RS12565	COG5444	nuclease activity
HW369_RS12655	COG0579	oxidoreductase
HW369_RS12770	COG0277	FAD linked oxidase domain protein
HW369_RS12785	COG3340	Belongs to the peptidase S51 family
HW369_RS12810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW369_RS12815	COG1388	LysM domain
HW369_RS12815	COG3584	3D domain protein
HW369_RS12820	COG2814	Major facilitator Superfamily
HW369_RS12825	COG2323	membrane
HW369_RS12830	COG3279	Response regulator of the LytR AlgR family
HW369_RS12845	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS12875	COG1278	Cold shock
HW369_RS12880	COG0028	Belongs to the TPP enzyme family
HW369_RS12890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS12895	COG1278	Cold shock
HW369_RS12900	COG2084	Dehydrogenase
HW369_RS12910	COG1131	(ABC) transporter
HW369_RS12915	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW369_RS12925	COG0737	Belongs to the 5'-nucleotidase family
HW369_RS12930	COG2310	stress, protein
HW369_RS12935	COG2310	stress, protein
HW369_RS12940	COG2310	stress, protein
HW369_RS12950	COG3853	Toxic anion resistance protein (TelA)
HW369_RS12955	COG1349	DNA-binding transcription factor activity
HW369_RS12960	COG0673	inositol 2-dehydrogenase activity
HW369_RS12980	COG0708	Exodeoxyribonuclease III
HW369_RS12985	COG1846	Transcriptional regulator
HW369_RS12995	COG1566	PFAM secretion protein HlyD family protein
HW369_RS13000	COG0534	Mate efflux family protein
HW369_RS13125	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS13130	COG1515	deoxyribonuclease V activity
HW369_RS13135	COG0586	Pfam SNARE associated Golgi protein
HW369_RS13145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS13180	COG2197	response regulator
HW369_RS13190	COG1131	(ABC) transporter
HW369_RS13210	COG2610	gluconate transmembrane transporter activity
HW369_RS13220	COG0693	protein deglycase activity
HW369_RS13225	COG3835	regulator
HW369_RS13230	COG0277	FAD linked oxidase domain protein
HW369_RS13235	COG0247	lactate metabolic process
HW369_RS13240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS13260	COG0679	Auxin Efflux Carrier
HW369_RS13265	COG0583	DNA-binding transcription factor activity
HW369_RS13270	COG0163	prenyltransferase activity
HW369_RS13275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HW369_RS13295	COG2271	Major facilitator Superfamily
HW369_RS13300	COG1473	amidohydrolase
HW369_RS13305	COG0281	malic enzyme
HW369_RS13310	COG0679	Auxin Efflux Carrier
HW369_RS13315	COG1252	NADH dehydrogenase
HW369_RS13330	COG0004	ammonium transporteR
HW369_RS13350	COG1114	Component of the transport system for branched-chain amino acids
HW369_RS13360	COG1363	Peptidase, m42
HW369_RS13435	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HW369_RS13440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS13450	COG0531	amino acid
HW369_RS13455	COG4282	regulation of fungal-type cell wall biogenesis
HW369_RS13470	COG5002	protein histidine kinase activity
HW369_RS13475	COG0745	RESPONSE REGULATOR receiver
HW369_RS13480	COG0659	secondary active sulfate transmembrane transporter activity
HW369_RS13485	COG0288	reversible hydration of carbon dioxide
HW369_RS13495	COG0789	Transcriptional regulator
HW369_RS13500	COG2814	Major facilitator Superfamily
HW369_RS13510	COG2814	Major facilitator Superfamily
HW369_RS13520	COG1295	ribonuclease BN
HW369_RS13535	COG1302	Protein conserved in bacteria
HW369_RS13540	COG1683	Conserved Protein
HW369_RS13545	COG2814	Major facilitator Superfamily
HW369_RS13560	COG1183	phosphatidylcholine synthase activity
HW369_RS13630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HW369_RS13650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW369_RS13655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS13685	COG0824	Thioesterase
HW369_RS13690	COG4841	protein insertion into membrane
HW369_RS13695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW369_RS13700	COG1832	CoA-binding protein
HW369_RS13705	COG0187	DNA topoisomerase II activity
HW369_RS13710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW369_RS13715	COG2267	carboxylic ester hydrolase activity
HW369_RS13720	COG1280	lysine exporter protein (LysE YggA)
HW369_RS13725	COG3403	YqcI/YcgG family
HW369_RS13735	COG1335	isochorismatase
HW369_RS13740	COG1247	-acetyltransferase
HW369_RS13750	COG0833	amino acid
HW369_RS13760	COG4819	ethanolamine utilization protein
HW369_RS13765	COG4303	Ethanolamine ammonia lyase large subunit
HW369_RS13770	COG4302	ethanolamine ammonia-lyase activity
HW369_RS13775	COG0531	amino acid
HW369_RS13790	COG4974	Belongs to the 'phage' integrase family
HW369_RS13800	COG1846	Transcriptional regulator
HW369_RS13805	COG1011	Hydrolase
HW369_RS13820	COG1914	H( )-stimulated, divalent metal cation uptake system
HW369_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS13850	COG2233	PERMEase
HW369_RS13855	COG0204	Acyl-transferase
HW369_RS13865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW369_RS13885	COG1227	inorganic diphosphatase activity
HW369_RS13890	COG2267	carboxylic ester hydrolase activity
HW369_RS13895	COG0129	dihydroxy-acid dehydratase activity
HW369_RS13900	COG2153	protein acetylation
HW369_RS13910	COG0697	spore germination
HW369_RS13930	COG2203	Gaf domain
HW369_RS13930	COG4585	Histidine kinase
HW369_RS13935	COG2197	response regulator
HW369_RS13940	COG0431	NADPH-dependent FMN reductase
HW369_RS13960	COG0183	Belongs to the thiolase family
HW369_RS13965	COG1268	BioY protein
HW369_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS13985	COG0463	Glycosyl transferase, family 2
HW369_RS14010	COG0596	Alpha beta hydrolase
HW369_RS14015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS14045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HW369_RS14050	COG1914	H( )-stimulated, divalent metal cation uptake system
HW369_RS14055	COG4336	lyase activity
HW369_RS14060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW369_RS14065	COG1984	allophanate hydrolase subunit 2
HW369_RS14070	COG0511	ligase activity, forming carbon-carbon bonds
HW369_RS14075	COG0439	Biotin carboxylase
HW369_RS14080	COG1414	Transcriptional regulator
HW369_RS14085	COG1587	Uroporphyrinogen-III synthase
HW369_RS14090	COG3883	PFAM NLP P60 protein
HW369_RS14090	COG0791	NLP P60 protein
HW369_RS14095	COG3663	DNA glycosylase
HW369_RS14100	COG1408	metallophosphoesterase
HW369_RS14120	COG0840	transmembrane signaling receptor activity
HW369_RS14130	COG0277	FAD linked oxidase domain protein
HW369_RS14135	COG2271	Major facilitator Superfamily
HW369_RS14150	COG5609	conserved protein (DUF2294)
HW369_RS14155	COG2116	formate transmembrane transporter activity
HW369_RS14255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW369_RS14260	COG2720	vancomycin resistance protein
HW369_RS14265	COG1846	Transcriptional regulator
HW369_RS14270	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS14275	COG0702	epimerase
HW369_RS14280	COG0494	nUDIX hydrolase
HW369_RS14295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW369_RS14345	COG1136	(ABC) transporter
HW369_RS14350	COG3011	Protein conserved in bacteria
HW369_RS14365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW369_RS14375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW369_RS14380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS14395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS14400	COG0697	spore germination
HW369_RS14410	COG3757	hydrolase, family 25
HW369_RS14410	COG3409	Peptidoglycan-binding domain 1 protein
HW369_RS14415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW369_RS14440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW369_RS14445	COG0326	Molecular chaperone. Has ATPase activity
HW369_RS14455	COG3739	integral membrane protein
HW369_RS14460	COG2368	4-hydroxyphenylacetate
HW369_RS14470	COG3386	PFAM SMP-30 Gluconolaconase
HW369_RS14480	COG2267	carboxylic ester hydrolase activity
HW369_RS14495	COG0640	Transcriptional regulator
HW369_RS14500	COG3832	glyoxalase III activity
HW369_RS14505	COG2202	Pas domain
HW369_RS14505	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS14510	COG2188	Transcriptional regulator
HW369_RS14515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS14520	COG0395	ABC-type sugar transport system, permease component
HW369_RS14525	COG1175	transmembrane transport
HW369_RS14530	COG1653	transport
HW369_RS14535	COG2222	sugar isomerase
HW369_RS14540	COG3842	ATPase activity
HW369_RS14550	COG1033	growth of symbiont in host cell
HW369_RS14550	COG2409	Drug exporters of the RND superfamily
HW369_RS14555	COG1846	Transcriptional regulator
HW369_RS14560	COG2814	Major facilitator Superfamily
HW369_RS14565	COG0531	amino acid
HW369_RS14575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW369_RS14580	COG3119	arylsulfatase activity
HW369_RS14590	COG3773	Cell wall hydrolase
HW369_RS14595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW369_RS14605	COG3977	Valine--pyruvate aminotransferase
HW369_RS14625	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW369_RS14630	COG0738	Major facilitator superfamily
HW369_RS14635	COG1979	alcohol dehydrogenase
HW369_RS14650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS14655	COG0833	amino acid
HW369_RS14665	COG1509	lysine 2,3-aminomutase activity
HW369_RS14685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW369_RS14690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW369_RS14695	COG0183	Belongs to the thiolase family
HW369_RS14705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW369_RS14715	COG1141	Ferredoxin
HW369_RS14730	COG1024	Enoyl-CoA hydratase
HW369_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS14740	COG1960	acyl-CoA dehydrogenase activity
HW369_RS14745	COG2045	Belongs to the ComB family
HW369_RS14760	COG1024	Enoyl-CoA hydratase
HW369_RS14765	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW369_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS14795	COG4191	Histidine kinase
HW369_RS14805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW369_RS14815	COG0019	diaminopimelate decarboxylase activity
HW369_RS14820	COG1301	dicarboxylic acid transport
HW369_RS14830	COG0583	DNA-binding transcription factor activity
HW369_RS14835	COG4122	O-methyltransferase activity
HW369_RS14860	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW369_RS14865	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS14870	COG2610	gluconate transmembrane transporter activity
HW369_RS14880	COG2851	Citrate transporter
HW369_RS14885	COG4565	transcriptional regulatory protein
HW369_RS14890	COG3290	protein histidine kinase activity
HW369_RS14895	COG0300	oxidoreductase activity
HW369_RS14905	COG0778	Nitroreductase
HW369_RS14945	COG5002	protein histidine kinase activity
HW369_RS14955	COG3757	hydrolase, family 25
HW369_RS14955	COG3409	Peptidoglycan-binding domain 1 protein
HW369_RS14965	COG0114	fumarate hydratase activity
HW369_RS14980	COG2176	DNA-directed DNA polymerase activity
HW369_RS14990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW369_RS15000	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS15010	COG0346	lactoylglutathione lyase activity
HW369_RS15015	COG0110	maltose O-acetyltransferase activity
HW369_RS15055	COG1295	ribonuclease BN
HW369_RS15065	COG1834	amidinotransferase
HW369_RS15070	COG2409	Drug exporters of the RND superfamily
HW369_RS15085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HW369_RS15100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW369_RS15105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW369_RS15110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW369_RS15115	COG5002	protein histidine kinase activity
HW369_RS15135	COG1388	LysM domain
HW369_RS15135	COG3584	3D domain protein
HW369_RS15145	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HW369_RS15160	COG1846	Transcriptional regulator
HW369_RS15165	COG1764	response to oxidative stress
HW369_RS15180	COG1595	DNA-templated transcription, initiation
HW369_RS15190	COG1131	(ABC) transporter
HW369_RS15195	COG1725	Transcriptional regulator
HW369_RS15200	COG0583	DNA-binding transcription factor activity
HW369_RS15210	COG2814	Major facilitator Superfamily
HW369_RS15230	COG1575	Belongs to the MenA family. Type 1 subfamily
HW369_RS15250	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS15265	COG0514	ATP-dependent DNA helicase (RecQ)
HW369_RS15305	COG2720	vancomycin resistance protein
HW369_RS15315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS15325	COG0697	spore germination
HW369_RS15335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS15340	COG1757	Na H antiporter
HW369_RS15360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS15385	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW369_RS15390	COG0551	DNA topoisomerase type I activity
HW369_RS15390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW369_RS15410	COG1533	DNA photolyase activity
HW369_RS15425	COG1609	Transcriptional regulator
HW369_RS15430	COG1757	Na H antiporter
HW369_RS15435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW369_RS15440	COG1131	(ABC) transporter
HW369_RS15455	COG0531	amino acid
HW369_RS15460	COG0697	spore germination
HW369_RS15465	COG0488	(ABC) transporter
HW369_RS15470	COG0697	spore germination
HW369_RS15475	COG2207	Transcriptional regulator
HW369_RS15475	COG0662	Cupin 2, conserved barrel domain protein
HW369_RS15490	COG0772	Belongs to the SEDS family
HW369_RS15495	COG0598	Magnesium transport protein CorA
HW369_RS15505	COG4974	Belongs to the 'phage' integrase family
HW369_RS15510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS15515	COG2223	nitrite transmembrane transporter activity
HW369_RS15520	COG1254	Belongs to the acylphosphatase family
HW369_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS15530	COG1404	Belongs to the peptidase S8 family
HW369_RS15535	COG1098	S1 RNA binding domain
HW369_RS15540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW369_RS15545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW369_RS15550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW369_RS15555	COG1335	isochorismatase
HW369_RS15560	COG0494	nUDIX hydrolase
HW369_RS15575	COG1396	sequence-specific DNA binding
HW369_RS15595	COG3541	Predicted nucleotidyltransferase
HW369_RS15620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS15650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW369_RS15655	COG1378	Sugar-specific transcriptional regulator TrmB
HW369_RS15670	COG0384	phenazine biosynthesis protein PhzF
HW369_RS15680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW369_RS15680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW369_RS15690	COG1657	PFAM Prenyltransferase squalene oxidase
HW369_RS15710	COG1119	ATPase activity
HW369_RS15715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS15720	COG1994	Peptidase M50
HW369_RS15725	COG2207	Transcriptional regulator
HW369_RS15735	COG0697	spore germination
HW369_RS15740	COG4548	von Willebrand factor, type A
HW369_RS15745	COG0714	Associated with various cellular activities
HW369_RS15750	COG4873	Protein conserved in bacteria
HW369_RS15755	COG1595	DNA-templated transcription, initiation
HW369_RS15780	COG3871	stress protein (general stress protein 26)
HW369_RS15790	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HW369_RS15795	COG2814	Major facilitator Superfamily
HW369_RS15805	COG0454	-acetyltransferase
HW369_RS15815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW369_RS15820	COG2094	Belongs to the DNA glycosylase MPG family
HW369_RS15825	COG1082	Xylose isomerase domain protein TIM barrel
HW369_RS15830	COG0673	inositol 2-dehydrogenase activity
HW369_RS15850	COG3773	Cell wall hydrolase
HW369_RS15855	COG0733	neurotransmitter:sodium symporter activity
HW369_RS15870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW369_RS15875	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS15880	COG0640	Transcriptional regulator
HW369_RS15885	COG0300	oxidoreductase activity
HW369_RS15895	COG1233	COG1233 Phytoene dehydrogenase and related
HW369_RS15900	COG2032	superoxide dismutase activity
HW369_RS15910	COG0527	aspartate kinase activity
HW369_RS15915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW369_RS15915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW369_RS15915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW369_RS15920	COG1105	Belongs to the carbohydrate kinase PfkB family
HW369_RS15925	COG1349	DNA-binding transcription factor activity
HW369_RS15940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS15965	COG0745	RESPONSE REGULATOR receiver
HW369_RS15980	COG5583	Uncharacterized small protein (DUF2292)
HW369_RS15990	COG0745	RESPONSE REGULATOR receiver
HW369_RS15995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW369_RS16000	COG2246	polysaccharide biosynthetic process
HW369_RS16005	COG0463	Glycosyl transferase, family 2
HW369_RS16010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HW369_RS16025	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS16030	COG1346	cytolysis
HW369_RS16035	COG1380	Effector of murein hydrolase LrgA
HW369_RS16040	COG1846	Transcriptional regulator
HW369_RS16050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS16065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW369_RS16085	COG0493	'glutamate synthase
HW369_RS16090	COG0067	glutamate synthase
HW369_RS16090	COG0069	glutamate synthase activity
HW369_RS16090	COG0070	glutamate synthase
HW369_RS16095	COG0583	DNA-binding transcription factor activity
HW369_RS16130	COG0789	Transcriptional regulator
HW369_RS16145	COG4195	phage-related replication protein
HW369_RS16150	COG0109	protoheme IX farnesyltransferase activity
HW369_RS16155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS16170	COG3428	Bacterial PH domain
HW369_RS16175	COG3402	PFAM membrane-flanked domain
HW369_RS16180	COG0281	malic enzyme
HW369_RS16185	COG1611	Belongs to the LOG family
HW369_RS16225	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS16235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS16240	COG0196	riboflavin kinase activity
HW369_RS16245	COG1126	abc transporter atp-binding protein
HW369_RS16250	COG0765	amino acid transport
HW369_RS16255	COG0765	amino acid transport
HW369_RS16260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW369_RS16265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW369_RS16270	COG0456	acetyltransferase
HW369_RS16280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS16285	COG0561	phosphatase activity
HW369_RS16290	COG3493	citrate carrier protein
HW369_RS16295	COG0281	malic enzyme
HW369_RS16305	COG3104	oligopeptide transport
HW369_RS16310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW369_RS16315	COG5002	protein histidine kinase activity
HW369_RS16320	COG0745	RESPONSE REGULATOR receiver
HW369_RS16330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW369_RS16335	COG3594	Acyltransferase
HW369_RS16340	COG0833	amino acid
HW369_RS16350	COG1757	Na H antiporter
HW369_RS16355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW369_RS16360	COG3361	conserved protein (COG2071)
HW369_RS16375	COG1360	Flagellar Motor Protein
HW369_RS16380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW369_RS16395	COG2112	serine threonine protein kinase
HW369_RS16400	COG2124	cytochrome p450
HW369_RS16405	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS16410	COG1523	belongs to the glycosyl hydrolase 13 family
HW369_RS16415	COG1823	symporter activity
HW369_RS16425	COG5002	protein histidine kinase activity
HW369_RS16430	COG2234	aminopeptidase activity
HW369_RS16460	COG3853	Toxic anion resistance protein (TelA)
HW369_RS16470	COG1368	sulfuric ester hydrolase activity
HW369_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS16500	COG0534	Mate efflux family protein
HW369_RS16505	COG2002	toxin-antitoxin pair type II binding
HW369_RS16525	COG1595	DNA-templated transcription, initiation
HW369_RS16530	COG3011	Protein conserved in bacteria
HW369_RS16535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW369_RS16540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW369_RS16545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW369_RS16550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW369_RS16560	COG0322	excinuclease ABC activity
HW369_RS16565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW369_RS16585	COG2962	Rard protein
HW369_RS16590	COG2096	Adenosyltransferase
HW369_RS16600	COG0406	alpha-ribazole phosphatase activity
HW369_RS16605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HW369_RS16610	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HW369_RS16620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HW369_RS16630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW369_RS16635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS16645	COG2521	methyltransferase
HW369_RS16645	COG2136	Putative SAM-dependent methyltransferase
HW369_RS16655	COG0726	polysaccharide deacetylase
HW369_RS16660	COG1413	lyase activity
HW369_RS16665	COG0488	(ABC) transporter
HW369_RS16670	COG1418	mRNA catabolic process
HW369_RS16675	COG0386	Belongs to the glutathione peroxidase family
HW369_RS16690	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HW369_RS16740	COG1876	peptidase activity
HW369_RS16745	COG0561	phosphatase activity
HW369_RS16760	COG5566	PFAM Mor transcription activator
HW369_RS16770	COG2264	protein methyltransferase activity
HW369_RS16790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW369_RS16790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW369_RS16795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW369_RS16795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW369_RS16800	COG1733	regulation of RNA biosynthetic process
HW369_RS16805	COG2814	Major facilitator Superfamily
HW369_RS16810	COG0473	3-isopropylmalate dehydrogenase activity
HW369_RS16815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW369_RS16830	COG2323	membrane
HW369_RS16835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HW369_RS16840	COG2050	protein possibly involved in aromatic compounds catabolism
HW369_RS16845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW369_RS16850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW369_RS16855	COG0640	Transcriptional regulator
HW369_RS16890	COG2271	Major facilitator Superfamily
HW369_RS16895	COG1388	LysM domain
HW369_RS16905	COG2217	Heavy metal translocating P-type atpase
HW369_RS16910	COG2608	mercury ion transmembrane transporter activity
HW369_RS16915	COG1937	Protein conserved in bacteria
HW369_RS16920	COG0745	RESPONSE REGULATOR receiver
HW369_RS16925	COG5002	protein histidine kinase activity
HW369_RS16940	COG0589	response to stress
HW369_RS16965	COG2211	Major facilitator Superfamily
HW369_RS16975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW369_RS16980	COG0628	permease
HW369_RS17020	COG1846	Transcriptional regulator
HW369_RS17035	COG3284	Transcriptional regulator
HW369_RS17040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW369_RS17045	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW369_RS17050	COG0022	dehydrogenase e1 component
HW369_RS17055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW369_RS17065	COG2252	PERMEase
HW369_RS17075	COG2072	flavoprotein involved in K transport
HW369_RS17080	COG1612	heme a metabolic process
HW369_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS17090	COG0589	response to stress
HW369_RS17100	COG1845	cytochrome c oxidase, subunit III
HW369_RS17105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW369_RS17115	COG1309	transcriptional regulator
HW369_RS17130	COG0517	IMP dehydrogenase activity
HW369_RS17165	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS17185	COG0477	Major facilitator Superfamily
HW369_RS17200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW369_RS17205	COG4608	Belongs to the ABC transporter superfamily
HW369_RS17210	COG0444	Belongs to the ABC transporter superfamily
HW369_RS17215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW369_RS17220	COG0601	transmembrane transport
HW369_RS17230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW369_RS17235	COG0574	Belongs to the PEP-utilizing enzyme family
HW369_RS17235	COG3848	Pyruvate phosphate dikinase
HW369_RS17275	COG2002	toxin-antitoxin pair type II binding
HW369_RS17300	COG1902	pentaerythritol trinitrate reductase activity
HW369_RS17305	COG0640	Transcriptional regulator
HW369_RS17325	COG2207	Transcriptional regulator
HW369_RS17330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW369_RS17340	COG1051	belongs to the nudix hydrolase family
HW369_RS17405	COG1714	RDD family
HW369_RS17435	COG2186	Transcriptional regulator
HW369_RS17445	COG5505	Protein of unknown function (DUF819)
HW369_RS17465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW369_RS17475	COG0583	DNA-binding transcription factor activity
HW369_RS17485	COG2807	transmembrane transport
HW369_RS17500	COG1733	regulation of RNA biosynthetic process
HW369_RS17540	COG2318	DinB family
HW369_RS17555	COG1522	sequence-specific DNA binding
HW369_RS17560	COG2271	Major facilitator Superfamily
HW369_RS17565	COG1846	Transcriptional regulator
HW369_RS17565	COG0456	acetyltransferase
HW369_RS17575	COG0697	spore germination
HW369_RS17580	COG0789	Transcriptional regulator
HW369_RS17585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS17590	COG0697	spore germination
HW369_RS17605	COG0814	amino acid
HW369_RS17610	COG0697	spore germination
HW369_RS17625	COG1309	transcriptional regulator
HW369_RS17630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS17675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW369_RS17685	COG1114	Component of the transport system for branched-chain amino acids
HW369_RS17690	COG0488	(ABC) transporter
HW369_RS17695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW369_RS17700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW369_RS17710	COG0151	Belongs to the GarS family
HW369_RS17730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW369_RS17815	COG2261	transglycosylase associated protein
HW369_RS17835	COG2217	Heavy metal translocating P-type atpase
HW369_RS17850	COG0701	Predicted permease
HW369_RS17860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW369_RS17865	COG2814	Major facilitator Superfamily
HW369_RS17870	COG1846	Transcriptional regulator
HW369_RS17895	COG2318	DinB family
HW369_RS17905	COG0840	transmembrane signaling receptor activity
HW369_RS17910	COG0753	catalase activity
HW369_RS17915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW369_RS17920	COG0577	efflux transmembrane transporter activity
HW369_RS17925	COG1136	(ABC) transporter
HW369_RS17930	COG2205	protein histidine kinase activity
HW369_RS17935	COG0745	RESPONSE REGULATOR receiver
HW369_RS17980	COG0517	IMP dehydrogenase activity
HW369_RS18030	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS18040	COG1785	Belongs to the alkaline phosphatase family
HW369_RS18050	COG1994	Peptidase M50
HW369_RS18065	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW369_RS18110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW369_RS18115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW369_RS18120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HW369_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS18135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW369_RS18140	COG0736	holo-[acyl-carrier-protein] synthase activity
HW369_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS18165	COG0789	Transcriptional regulator
HW369_RS18170	COG0697	spore germination
HW369_RS18175	COG2318	DinB family
HW369_RS18185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW369_RS18195	COG0346	lactoylglutathione lyase activity
HW369_RS18230	COG0583	DNA-binding transcription factor activity
HW369_RS18255	COG3239	Fatty acid desaturase
HW369_RS18285	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS18325	COG0640	Transcriptional regulator
HW369_RS18330	COG1396	sequence-specific DNA binding
HW369_RS18340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW369_RS18355	COG0306	phosphate transporter
HW369_RS18360	COG0346	lactoylglutathione lyase activity
HW369_RS18365	COG0640	Transcriptional regulator
HW369_RS18375	COG0640	Transcriptional regulator
HW369_RS18380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW369_RS18435	COG0697	spore germination
HW369_RS18440	COG0789	Transcriptional regulator
HW369_RS18450	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS18475	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS18490	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS18495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW369_RS18495	COG1017	nitric oxide dioxygenase activity
HW369_RS18505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS18510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS18520	COG0697	spore germination
HW369_RS18540	COG2002	toxin-antitoxin pair type II binding
HW369_RS18555	COG1253	flavin adenine dinucleotide binding
HW369_RS18560	COG2738	Putative neutral zinc metallopeptidase
HW369_RS18565	COG0789	Transcriptional regulator
HW369_RS18590	COG0745	RESPONSE REGULATOR receiver
HW369_RS18595	COG2205	protein histidine kinase activity
HW369_RS18615	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HW369_RS18630	COG2312	Erythromycin esterase
HW369_RS18635	COG2318	DinB family
HW369_RS18640	COG1476	TRANSCRIPTIONal
HW369_RS18670	COG1846	Transcriptional regulator
HW369_RS18680	COG2076	Multidrug Resistance protein
HW369_RS18685	COG2318	DinB family
HW369_RS18695	COG0477	Major facilitator Superfamily
HW369_RS18705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS18710	COG1846	Transcriptional regulator
HW369_RS18715	COG1733	regulation of RNA biosynthetic process
HW369_RS18720	COG2085	NADP oxidoreductase coenzyme F420-dependent
HW369_RS18730	COG1609	Transcriptional regulator
HW369_RS18735	COG0673	inositol 2-dehydrogenase activity
HW369_RS18740	COG1082	Xylose isomerase domain protein TIM barrel
HW369_RS18745	COG2814	Major facilitator Superfamily
HW369_RS18750	COG0640	Transcriptional regulator
HW369_RS18755	COG1063	alcohol dehydrogenase
HW369_RS18790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW369_RS18805	COG1393	Belongs to the ArsC family
HW369_RS18830	COG1994	Peptidase M50
HW369_RS18880	COG0772	Belongs to the SEDS family
HW369_RS18910	COG3655	Transcriptional regulator
HW369_RS18965	COG5002	protein histidine kinase activity
HW369_RS18970	COG0546	phosphoglycolate phosphatase activity
HW369_RS19035	COG1113	amino acid transport
HW369_RS19070	COG1027	Aspartate ammonia-lyase
HW369_RS19085	COG2376	Dihydroxyacetone kinase
HW369_RS19095	COG2207	Transcriptional regulator
HW369_RS19105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS19110	COG1733	regulation of RNA biosynthetic process
HW369_RS19120	COG0697	spore germination
HW369_RS19125	COG5553	Cysteine dioxygenase type I
HW369_RS19130	COG0346	lactoylglutathione lyase activity
HW369_RS19135	COG0640	Transcriptional regulator
HW369_RS19140	COG0640	Transcriptional regulator
HW369_RS19145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW369_RS19165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS19170	COG2226	methyltransferase
HW369_RS19200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW369_RS19205	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS19210	COG1388	LysM domain
HW369_RS19210	COG3858	chitin binding
HW369_RS19215	COG0477	Major facilitator Superfamily
HW369_RS19220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS19225	COG2172	sigma factor antagonist activity
HW369_RS19245	COG0534	Mate efflux family protein
HW369_RS19250	COG4608	Belongs to the ABC transporter superfamily
HW369_RS19255	COG0444	Belongs to the ABC transporter superfamily
HW369_RS19260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW369_RS19265	COG0601	transmembrane transport
HW369_RS19270	COG0747	negative chemotaxis
HW369_RS19275	COG0583	DNA-binding transcription factor activity
HW369_RS19280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW369_RS19290	COG2323	membrane
HW369_RS19295	COG0517	IMP dehydrogenase activity
HW369_RS19320	COG0028	Belongs to the TPP enzyme family
HW369_RS19330	COG1278	Cold shock
HW369_RS19340	COG0513	Belongs to the DEAD box helicase family
HW369_RS19350	COG1278	Cold shock
HW369_RS19390	COG0697	spore germination
HW369_RS19400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW369_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS19455	COG0583	DNA-binding transcription factor activity
HW369_RS19490	COG2318	DinB family
HW369_RS19515	COG0698	ribose 5-phosphate isomerase
HW369_RS19535	COG2186	Transcriptional regulator
HW369_RS19540	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS19545	COG3958	Transketolase
HW369_RS19550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW369_RS19555	COG2814	Major facilitator Superfamily
HW369_RS19560	COG1309	transcriptional regulator
HW369_RS19565	COG0574	Belongs to the PEP-utilizing enzyme family
HW369_RS19565	COG3848	Pyruvate phosphate dikinase
HW369_RS19610	COG0640	Transcriptional regulator
HW369_RS19615	COG0456	acetyltransferase
HW369_RS19620	COG1846	Transcriptional regulator
HW369_RS19625	COG2364	Membrane
HW369_RS19640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS19645	COG0789	Transcriptional regulator
HW369_RS19665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW369_RS19670	COG1288	antiporter activity
HW369_RS19675	COG0473	3-isopropylmalate dehydrogenase activity
HW369_RS19690	COG1846	Transcriptional regulator
HW369_RS19695	COG0010	Belongs to the arginase family
HW369_RS19700	COG1228	amidohydrolase
HW369_RS19710	COG2986	histidine ammonia-lyase
HW369_RS19715	COG0656	L-ascorbic acid biosynthetic process
HW369_RS19725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW369_RS19735	COG0024	Methionine aminopeptidase
HW369_RS19740	COG1621	beta-fructofuranosidase activity
HW369_RS19745	COG3716	PTS system mannose fructose sorbose family IID component
HW369_RS19750	COG3715	PTS system
HW369_RS19755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS19760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW369_RS19765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HW369_RS19765	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HW369_RS19770	COG1621	beta-fructofuranosidase activity
HW369_RS19775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HW369_RS19790	COG1609	Transcriptional regulator
HW369_RS19810	COG1113	amino acid transport
HW369_RS19845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW369_RS19860	COG1113	amino acid transport
HW369_RS19865	COG1280	lysine exporter protein (LysE YggA)
HW369_RS19875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS19880	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS19895	COG2814	Major facilitator Superfamily
HW369_RS19905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW369_RS19910	COG0156	8-amino-7-oxononanoate synthase activity
HW369_RS19915	COG0477	Major facilitator Superfamily
HW369_RS19920	COG2193	ferroxidase activity
HW369_RS19925	COG1621	beta-fructofuranosidase activity
HW369_RS19930	COG1621	beta-fructofuranosidase activity
HW369_RS19935	COG0405	Gamma-glutamyltransferase
HW369_RS19940	COG1011	Hydrolase
HW369_RS19950	COG0531	amino acid
HW369_RS19960	COG2208	phosphoserine phosphatase activity
HW369_RS19965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW369_RS19970	COG0784	Response regulator, receiver
HW369_RS19970	COG2205	protein histidine kinase activity
HW369_RS19985	COG3448	diguanylate cyclase activity
HW369_RS19985	COG4175	Glycine betaine
HW369_RS19995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW369_RS20005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW369_RS20010	COG1733	regulation of RNA biosynthetic process
HW369_RS20015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW369_RS20045	COG4974	Belongs to the 'phage' integrase family
HW369_RS20085	COG1309	transcriptional regulator
HW369_RS20090	COG0861	Integral membrane protein TerC family
HW369_RS20100	COG5577	PFAM Coat F domain
HW369_RS20110	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS20120	COG1522	sequence-specific DNA binding
HW369_RS20125	COG3813	Protein conserved in bacteria
HW369_RS20165	COG2076	Multidrug Resistance protein
HW369_RS20215	COG1522	sequence-specific DNA binding
HW369_RS20220	COG3469	chitinase activity
HW369_RS20230	COG0697	spore germination
HW369_RS20285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW369_RS20290	COG2814	Major facilitator Superfamily
HW369_RS20300	COG0492	ferredoxin-NADP+ reductase activity
HW369_RS20305	COG1120	ATPase activity
HW369_RS20310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW369_RS20315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS20320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS20345	COG2814	Major facilitator Superfamily
HW369_RS20350	COG1566	PFAM secretion protein HlyD family protein
HW369_RS20355	COG1846	Transcriptional regulator
HW369_RS20365	COG1404	Belongs to the peptidase S8 family
HW369_RS20370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW369_RS20375	COG1785	Belongs to the alkaline phosphatase family
HW369_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS20395	COG2814	Major facilitator Superfamily
HW369_RS20405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW369_RS20410	COG1819	glycosyl
HW369_RS20415	COG0791	NLP P60 protein
HW369_RS20415	COG1388	LysM domain
HW369_RS20430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS20440	COG2205	protein histidine kinase activity
HW369_RS20445	COG3239	Fatty acid desaturase
HW369_RS20450	COG4585	Histidine kinase
HW369_RS20455	COG2197	response regulator
HW369_RS20480	COG1120	ATPase activity
HW369_RS20485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS20490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS20495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HW369_RS20500	COG0701	Predicted permease
HW369_RS20505	COG3689	TIGRFAM TIGR03943 family protein
HW369_RS20510	COG3300	MHYT domain
HW369_RS20510	COG5001	Diguanylate cyclase
HW369_RS20530	COG4608	Belongs to the ABC transporter superfamily
HW369_RS20535	COG0791	NLP P60 protein
HW369_RS20540	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW369_RS20545	COG4166	transmembrane transport
HW369_RS20550	COG0444	Belongs to the ABC transporter superfamily
HW369_RS20555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW369_RS20560	COG0601	transmembrane transport
HW369_RS20565	COG2362	D-Aminopeptidase
HW369_RS20570	COG2233	PERMEase
HW369_RS20580	COG2814	Major facilitator Superfamily
HW369_RS20605	COG0328	RNA-DNA hybrid ribonuclease activity
HW369_RS20610	COG0328	RNA-DNA hybrid ribonuclease activity
HW369_RS20635	COG3541	Predicted nucleotidyltransferase
HW369_RS20640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW369_RS20645	COG1755	Isoprenylcysteine carboxyl methyltransferase
HW369_RS20650	COG3424	synthase
HW369_RS20660	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS20665	COG0583	DNA-binding transcription factor activity
HW369_RS20670	COG2233	PERMEase
HW369_RS20675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW369_RS20680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HW369_RS20685	COG1199	ATP-dependent helicase activity
HW369_RS20695	COG3842	ATPase activity
HW369_RS20705	COG1175	transmembrane transport
HW369_RS20720	COG0116	Belongs to the methyltransferase superfamily
HW369_RS20725	COG0366	Alpha amylase catalytic
HW369_RS20730	COG2197	response regulator
HW369_RS20760	COG3599	regulation of cell shape
HW369_RS20765	COG4474	Belongs to the UPF0398 family
HW369_RS20775	COG3359	exonuclease
HW369_RS20780	COG1205	dead DEAH box helicase
HW369_RS20780	COG1111	helicase
HW369_RS20790	COG3706	GGDEF domain
HW369_RS20820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW369_RS20835	COG0626	cystathionine gamma-synthase activity
HW369_RS20840	COG0626	cystathionine gamma-synthase activity
HW369_RS20855	COG5337	Spore coat protein CotH
HW369_RS20905	COG3331	DNA recombination
HW369_RS20910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW369_RS20910	COG4499	WXG100 protein secretion system (Wss), protein YukC
HW369_RS20920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW369_RS20925	COG3935	DnaD domain protein
HW369_RS20930	COG0017	Asparaginyl-tRNA synthetase
HW369_RS20935	COG0436	Aminotransferase
HW369_RS20955	COG1199	ATP-dependent helicase activity
HW369_RS20955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW369_RS20960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW369_RS20965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW369_RS20975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HW369_RS20975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HW369_RS20980	COG0617	tRNA 3'-terminal CCA addition
HW369_RS20985	COG0438	transferase activity, transferring glycosyl groups
HW369_RS20990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW369_RS20995	COG1803	Methylglyoxal synthase
HW369_RS21000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW369_RS21005	COG1694	Mazg nucleotide pyrophosphohydrolase
HW369_RS21010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS21015	COG2738	Putative neutral zinc metallopeptidase
HW369_RS21025	COG2340	Cysteine-rich secretory protein family
HW369_RS21030	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HW369_RS21040	COG3336	cytochrome c oxidase
HW369_RS21065	COG0109	protoheme IX farnesyltransferase activity
HW369_RS21070	COG1612	heme a metabolic process
HW369_RS21075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW369_RS21080	COG0772	Belongs to the SEDS family
HW369_RS21085	COG4838	Belongs to the UPF0358 family
HW369_RS21090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW369_RS21095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW369_RS21110	COG4896	Protein conserved in bacteria
HW369_RS21125	COG1217	gtp-binding protein TYPA
HW369_RS21135	COG0483	inositol monophosphate 1-phosphatase activity
HW369_RS21145	COG4493	Belongs to the UPF0637 family
HW369_RS21150	COG4476	Belongs to the UPF0223 family
HW369_RS21155	COG1982	Orn Lys Arg decarboxylase major
HW369_RS21165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW369_RS21180	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW369_RS21185	COG0022	dehydrogenase e1 component
HW369_RS21210	COG0561	phosphatase activity
HW369_RS21215	COG5503	Protein of unknown function (DUF1447)
HW369_RS21220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW369_RS21225	COG0569	domain protein
HW369_RS21230	COG1132	(ABC) transporter
HW369_RS21235	COG1132	(ABC) transporter
HW369_RS21240	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HW369_RS21245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS21250	COG0450	alkyl hydroperoxide reductase
HW369_RS21255	COG0668	transmembrane transport
HW369_RS21265	COG1473	amidohydrolase
HW369_RS21270	COG2171	N-acyltransferase activity
HW369_RS21275	COG0583	DNA-binding transcription factor activity
HW369_RS21280	COG0517	IMP dehydrogenase activity
HW369_RS21285	COG4703	Protein of unknown function (DUF1797)
HW369_RS21300	COG2200	EAL domain
HW369_RS21305	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS21310	COG1408	metallophosphoesterase
HW369_RS21325	COG0248	Ppx GppA phosphatase
HW369_RS21330	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS21340	COG0784	Response regulator, receiver
HW369_RS21340	COG0835	chemotaxis
HW369_RS21360	COG0436	Aminotransferase
HW369_RS21365	COG0778	Nitroreductase
HW369_RS21370	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS21375	COG0456	acetyltransferase
HW369_RS21385	COG0583	DNA-binding transcription factor activity
HW369_RS21395	COG1346	cytolysis
HW369_RS21410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS21410	COG2190	(PTS) system
HW369_RS21410	COG1263	PTS System
HW369_RS21415	COG3711	transcriptional antiterminator
HW369_RS21425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW369_RS21435	COG0307	riboflavin synthase, alpha
HW369_RS21440	COG3949	Membrane
HW369_RS21445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW369_RS21445	COG0646	methionine synthase
HW369_RS21450	COG1410	methionine synthase
HW369_RS21450	COG0646	methionine synthase
HW369_RS21490	COG3773	Cell wall hydrolase
HW369_RS21510	COG4873	Protein conserved in bacteria
HW369_RS21520	COG0702	epimerase
HW369_RS21525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW369_RS21535	COG0720	synthase
HW369_RS21540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HW369_RS21560	COG0697	spore germination
HW369_RS21565	COG0300	oxidoreductase activity
HW369_RS21575	COG1757	Na H antiporter
HW369_RS21580	COG0542	response to heat
HW369_RS21590	COG4191	Histidine kinase
HW369_RS21600	COG1846	Transcriptional regulator
HW369_RS21630	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW369_RS21635	COG1129	ABC transporter
HW369_RS21645	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HW369_RS21650	COG0235	Class ii aldolase
HW369_RS21655	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HW369_RS21660	COG1850	ribulose-bisphosphate carboxylase activity
HW369_RS21665	COG0436	Aminotransferase
HW369_RS21670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW369_RS21675	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HW369_RS21680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW369_RS21690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW369_RS21695	COG5002	protein histidine kinase activity
HW369_RS21700	COG1556	Lactate utilization protein
HW369_RS21705	COG1139	Iron-sulfur cluster binding protein
HW369_RS21710	COG0247	lactate metabolic process
HW369_RS21720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW369_RS21725	COG2186	Transcriptional regulator
HW369_RS21745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW369_RS21750	COG3243	poly(R)-hydroxyalkanoic acid synthase
HW369_RS21780	COG1191	sigma factor activity
HW369_RS21785	COG0861	Integral membrane protein TerC family
HW369_RS21790	COG2205	protein histidine kinase activity
HW369_RS21790	COG0784	Response regulator, receiver
HW369_RS21795	COG3279	Response regulator of the LytR AlgR family
HW369_RS21800	COG1785	Belongs to the alkaline phosphatase family
HW369_RS21820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW369_RS21820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW369_RS21825	COG1846	Transcriptional regulator
HW369_RS21830	COG0789	Transcriptional regulator
HW369_RS21840	COG1668	transmembrane transport
HW369_RS21845	COG4555	ABC transporter
HW369_RS21860	COG2252	PERMEase
HW369_RS21880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW369_RS21880	COG0456	acetyltransferase
HW369_RS21895	COG4187	Peptidase family M20/M25/M40
HW369_RS21905	COG1473	amidohydrolase
HW369_RS21910	COG0456	acetyltransferase
HW369_RS21915	COG0840	transmembrane signaling receptor activity
HW369_RS21955	COG2105	PFAM AIG2 family protein
HW369_RS21955	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HW369_RS21960	COG0346	lactoylglutathione lyase activity
HW369_RS21970	COG0789	Transcriptional regulator
HW369_RS21975	COG1253	flavin adenine dinucleotide binding
HW369_RS21980	COG1131	(ABC) transporter
HW369_RS22015	COG1811	Na channel or pump
HW369_RS22020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS22020	COG2190	(PTS) system
HW369_RS22020	COG1263	PTS System
HW369_RS22025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW369_RS22030	COG0363	glucosamine-6-phosphate deaminase activity
HW369_RS22035	COG2188	Transcriptional regulator
HW369_RS22040	COG4821	SIS domain
HW369_RS22065	COG1404	Belongs to the peptidase S8 family
HW369_RS22070	COG0598	Magnesium transport protein CorA
HW369_RS22080	COG1316	TRANSCRIPTIONal
HW369_RS22095	COG0534	Mate efflux family protein
HW369_RS22115	COG4975	Glucose uptake
HW369_RS22120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS22130	COG2116	formate transmembrane transporter activity
HW369_RS22140	COG2146	nitrite reductase [NAD(P)H] activity
HW369_RS22145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW369_RS22175	COG2084	Dehydrogenase
HW369_RS22185	COG0069	glutamate synthase activity
HW369_RS22190	COG0028	Belongs to the TPP enzyme family
HW369_RS22200	COG4464	protein tyrosine phosphatase activity
HW369_RS22215	COG1316	TRANSCRIPTIONal
HW369_RS22225	COG1134	teichoic acid transport
HW369_RS22230	COG1682	transport, permease protein
HW369_RS22235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW369_RS22270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW369_RS22275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW369_RS22285	COG4464	protein tyrosine phosphatase activity
HW369_RS22290	COG0489	protein tyrosine kinase activity
HW369_RS22295	COG3944	biosynthesis protein
HW369_RS22300	COG1482	cell wall glycoprotein biosynthetic process
HW369_RS22315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW369_RS22325	COG0110	maltose O-acetyltransferase activity
HW369_RS22335	COG1216	Glycosyl transferase, family 2
HW369_RS22340	COG2244	polysaccharide biosynthetic process
HW369_RS22345	COG1215	transferase activity, transferring glycosyl groups
HW369_RS22355	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HW369_RS22360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW369_RS22365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW369_RS22370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW369_RS22385	COG2247	cell wall binding repeat
HW369_RS22385	COG2385	sporulation resulting in formation of a cellular spore
HW369_RS22390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW369_RS22395	COG1396	sequence-specific DNA binding
HW369_RS22410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW369_RS22450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW369_RS22465	COG3300	MHYT domain
HW369_RS22465	COG5001	Diguanylate cyclase
HW369_RS22480	COG0302	gtp cyclohydrolase
HW369_RS22485	COG5001	Diguanylate cyclase
HW369_RS22485	COG3300	MHYT domain
HW369_RS22510	COG5658	integral membrane protein
HW369_RS22515	COG0640	Transcriptional regulator
HW369_RS22530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW369_RS22535	COG0477	Major facilitator Superfamily
HW369_RS22545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW369_RS22565	COG4948	Mandelate Racemase Muconate Lactonizing
HW369_RS22575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW369_RS22590	COG0656	L-ascorbic acid biosynthetic process
HW369_RS22600	COG2385	sporulation resulting in formation of a cellular spore
HW369_RS22610	COG1388	LysM domain
HW369_RS22610	COG0791	NLP P60 protein
HW369_RS22625	COG0784	Response regulator, receiver
HW369_RS22630	COG4191	Histidine kinase
HW369_RS22640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW369_RS22650	COG0385	Bile acid
HW369_RS22665	COG1733	regulation of RNA biosynthetic process
HW369_RS22675	COG2199	diguanylate cyclase activity
HW369_RS22675	COG2200	EAL domain
HW369_RS22745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW369_RS22755	COG0154	amidase activity
HW369_RS22770	COG0667	Aldo Keto reductase
HW369_RS22785	COG0583	DNA-binding transcription factor activity
HW369_RS22790	COG2226	methyltransferase
HW369_RS22795	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS22810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HW369_RS22820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HW369_RS22825	COG2971	BadF BadG BcrA BcrD
HW369_RS22835	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW369_RS22845	COG1486	melibiose metabolic process
HW369_RS22865	COG1737	Transcriptional regulator
HW369_RS22870	COG1649	PFAM Uncharacterised BCR, COG1649
HW369_RS22955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW369_RS22960	COG5001	Diguanylate cyclase
HW369_RS22960	COG3706	GGDEF domain
HW369_RS22960	COG2203	Gaf domain
HW369_RS22960	COG4251	negative regulation of phosphorylation
HW369_RS22980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW369_RS22985	COG0450	alkyl hydroperoxide reductase
HW369_RS22990	COG0673	inositol 2-dehydrogenase activity
HW369_RS22995	COG2910	NAD(P)H-binding
HW369_RS23000	COG1278	Cold shock
HW369_RS23005	COG1131	(ABC) transporter
HW369_RS23015	COG0402	S-adenosylhomocysteine deaminase activity
HW369_RS23020	COG0531	amino acid
HW369_RS23035	COG0439	Biotin carboxylase
HW369_RS23050	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS23055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW369_RS23060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW369_RS23065	COG2271	Major facilitator Superfamily
HW369_RS23095	COG0628	permease
HW369_RS23100	COG0778	Nitroreductase
HW369_RS23115	COG1272	protein, Hemolysin III
HW369_RS23120	COG1914	H( )-stimulated, divalent metal cation uptake system
HW369_RS23125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HW369_RS23130	COG1984	allophanate hydrolase subunit 2
HW369_RS23135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW369_RS23140	COG2188	Transcriptional regulator
HW369_RS23145	COG0366	Alpha amylase catalytic
HW369_RS23150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS23150	COG1263	PTS System
HW369_RS23160	COG0710	3-dehydroquinate dehydratase activity
HW369_RS23170	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS23175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW369_RS23180	COG1609	Transcriptional regulator
HW369_RS23185	COG2252	PERMEase
HW369_RS23195	COG0402	S-adenosylhomocysteine deaminase activity
HW369_RS23210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW369_RS23220	COG2267	carboxylic ester hydrolase activity
HW369_RS23230	COG5002	protein histidine kinase activity
HW369_RS23235	COG0745	RESPONSE REGULATOR receiver
HW369_RS23280	COG1653	transport
HW369_RS23285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW369_RS23290	COG3583	domain protein
HW369_RS23290	COG3584	3D domain protein
HW369_RS23295	COG1879	ABC-type sugar transport system periplasmic component
HW369_RS23300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW369_RS23305	COG1129	ABC transporter
HW369_RS23315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW369_RS23320	COG1609	Transcriptional regulator
HW369_RS23335	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW369_RS23340	COG2814	Major facilitator Superfamily
HW369_RS23345	COG1566	PFAM secretion protein HlyD family protein
HW369_RS23350	COG1846	Transcriptional regulator
HW369_RS23355	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HW369_RS23360	COG0656	L-ascorbic acid biosynthetic process
HW369_RS23365	COG1414	Transcriptional regulator
HW369_RS23375	COG3162	membrane
HW369_RS23380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW369_RS23390	COG1132	(ABC) transporter
HW369_RS23395	COG1132	(ABC) transporter
HW369_RS23400	COG3321	synthase
HW369_RS23400	COG0604	alcohol dehydrogenase
HW369_RS23405	COG1733	regulation of RNA biosynthetic process
HW369_RS23410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW369_RS23415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW369_RS23420	COG1511	domain protein
HW369_RS23425	COG0456	acetyltransferase
HW369_RS23455	COG1733	regulation of RNA biosynthetic process
HW369_RS23460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW369_RS23465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW369_RS23470	COG1141	Ferredoxin
HW369_RS23475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW369_RS23480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW369_RS23485	COG1116	anion transmembrane transporter activity
HW369_RS23490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW369_RS23495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW369_RS23505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW369_RS23505	COG1263	PTS System
HW369_RS23510	COG1737	Transcriptional regulator
HW369_RS23545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS23550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW369_RS23555	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HW369_RS23560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW369_RS23565	COG0531	amino acid
HW369_RS23580	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS23585	COG1309	transcriptional regulator
HW369_RS23590	COG2113	Glycine betaine
HW369_RS23595	COG0517	IMP dehydrogenase activity
HW369_RS23595	COG4175	Glycine betaine
HW369_RS23600	COG4176	ABC-type proline glycine betaine transport system permease component
HW369_RS23605	COG2226	methyltransferase
HW369_RS23610	COG3180	Ammonia monooxygenase
HW369_RS23615	COG0583	DNA-binding transcription factor activity
HW369_RS23625	COG3181	Tripartite tricarboxylate transporter family receptor
HW369_RS23630	COG4565	transcriptional regulatory protein
HW369_RS23635	COG3290	protein histidine kinase activity
HW369_RS23640	COG2851	Citrate transporter
HW369_RS23655	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW369_RS23660	COG2040	homocysteine
HW369_RS23665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW369_RS23680	COG1368	sulfuric ester hydrolase activity
HW369_RS23690	COG1476	TRANSCRIPTIONal
HW369_RS23730	COG3290	protein histidine kinase activity
HW369_RS23735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW369_RS23740	COG1301	dicarboxylic acid transport
HW369_RS23750	COG0861	Integral membrane protein TerC family
HW369_RS23760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW369_RS23765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HW369_RS23775	COG0833	amino acid
HW369_RS23780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW369_RS23795	COG1063	alcohol dehydrogenase
HW369_RS23800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW369_RS23810	COG0577	efflux transmembrane transporter activity
HW369_RS23815	COG1136	(ABC) transporter
HW369_RS23820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW369_RS23835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW369_RS23840	COG0390	transport system, permease component
HW369_RS23855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HW369_RS23860	COG1607	acyl-coa hydrolase
HW369_RS23870	COG0531	amino acid
HW369_RS23875	COG4297	protein containing double-stranded beta helix domain
HW369_RS23885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW369_RS23890	COG1115	amino acid carrier protein
HW369_RS23895	COG2066	Belongs to the glutaminase family
HW369_RS23900	COG4191	Histidine kinase
HW369_RS23905	COG0784	Response regulator, receiver
HW369_RS23920	COG3052	prosthetic group binding
HW369_RS23945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW369_RS23950	COG2814	Major facilitator Superfamily
HW369_RS23955	COG1733	regulation of RNA biosynthetic process
HW369_RS23965	COG4895	conserved protein (DUF2196)
HW369_RS23975	COG0028	Belongs to the TPP enzyme family
HW369_RS23980	COG3527	Alpha-acetolactate decarboxylase
HW369_RS23990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW369_RS23990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW369_RS23995	COG0028	Belongs to the TPP enzyme family
HW369_RS23995	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HW369_RS24005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW369_RS24020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW369_RS24025	COG2223	nitrite transmembrane transporter activity
HW369_RS24030	COG0243	molybdopterin cofactor binding
HW369_RS24035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW369_RS24045	COG1346	cytolysis
HW369_RS24055	COG3279	Response regulator of the LytR AlgR family
HW369_RS24060	COG3275	phosphorelay sensor kinase activity
HW369_RS24065	COG1486	melibiose metabolic process
HW369_RS24070	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW369_RS24075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW369_RS24080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW369_RS24085	COG3711	transcriptional antiterminator
HW369_RS24085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW369_RS24095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW369_RS24105	COG1113	amino acid transport
HW369_RS24110	COG3142	Participates in the control of copper homeostasis
HW369_RS24135	COG1522	sequence-specific DNA binding
HW369_RS24155	COG1953	Uracil, thiamine, allantoin
HW369_RS24160	COG1070	Carbohydrate kinase
HW369_RS24165	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HW369_RS24170	COG1737	Transcriptional regulator
HW369_RS24180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW369_RS24190	COG2382	esterase
HW369_RS24200	COG2153	protein acetylation
HW369_RS24205	COG2323	membrane
HW369_RS24215	COG0210	DNA helicase
HW369_RS24270	COG0475	glutathione-regulated potassium exporter activity
HW369_RS24270	COG0569	domain protein
HW369_RS24275	COG2239	Acts as a magnesium transporter
HW369_RS24285	COG0564	pseudouridine synthase activity
HW369_RS24295	COG2357	RelA SpoT domain protein
HW369_RS24305	COG4116	CYTH
HW369_RS24310	COG0741	lytic transglycosylase activity
HW369_RS24315	COG2346	COG2346, Truncated hemoglobins
HW369_RS24320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW369_RS24330	COG1164	Oligoendopeptidase f
HW369_RS24340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS24350	COG0861	Integral membrane protein TerC family
HW369_RS24365	COG0583	DNA-binding transcription factor activity
HW369_RS24370	COG1393	Belongs to the ArsC family
HW369_RS24375	COG0531	amino acid
HW369_RS24385	COG1113	amino acid transport
HW369_RS24390	COG0456	acetyltransferase
HW369_RS24395	COG4608	Belongs to the ABC transporter superfamily
HW369_RS24400	COG0444	Belongs to the ABC transporter superfamily
HW369_RS24405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW369_RS24410	COG0601	transmembrane transport
HW369_RS24415	COG4166	transmembrane transport
HW369_RS24420	COG0180	Tryptophanyl-tRNA synthetase
HW369_RS24435	COG0601	transmembrane transport
HW369_RS24445	COG4608	Belongs to the ABC transporter superfamily
HW369_RS24450	COG0444	Belongs to the ABC transporter superfamily
HW369_RS24455	COG5504	Zn-dependent protease
HW369_RS24460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW369_RS24465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW369_RS24485	COG2267	carboxylic ester hydrolase activity
HW369_RS24495	COG2084	Dehydrogenase
HW369_RS24500	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW369_RS24505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW369_RS24520	COG0542	response to heat
HW369_RS24535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW369_RS24555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW369_RS24560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HW369_RS24565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW369_RS24570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW369_RS24575	COG2151	metal-sulfur cluster biosynthetic enzyme
HW369_RS24580	COG0561	phosphatase activity
HW369_RS24595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS24600	COG1307	EDD domain protein, DegV family
HW369_RS24610	COG2996	Protein conserved in bacteria
HW369_RS24615	COG1666	GTP binding
HW369_RS24620	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS24625	COG3829	transcription factor binding
HW369_RS24630	COG0833	amino acid
HW369_RS24635	COG4187	Peptidase family M20/M25/M40
HW369_RS24640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW369_RS24645	COG1012	belongs to the aldehyde dehydrogenase family
HW369_RS24650	COG1609	Transcriptional regulator
HW369_RS24655	COG0366	Alpha amylase catalytic
HW369_RS24655	COG1874	Beta-galactosidase
HW369_RS24660	COG0004	ammonium transporteR
HW369_RS24665	COG0347	Belongs to the P(II) protein family
HW369_RS24670	COG1562	ergosterol biosynthetic process
HW369_RS24685	COG0367	asparagine synthase
HW369_RS24700	COG2311	Membrane
HW369_RS24735	COG1403	HNH endonuclease
HW369_RS24740	COG0419	ATPase involved in DNA repair
HW369_RS24745	COG0420	3'-5' exonuclease activity
HW369_RS24750	COG1074	ATP-dependent DNA helicase activity
HW369_RS24755	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HW369_RS24760	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS24765	COG0398	Pfam SNARE associated Golgi protein
HW369_RS24770	COG0823	Involved in the tonB-independent uptake of proteins
HW369_RS24770	COG1506	peptidase
HW369_RS24770	COG4946	Tricorn protease homolog
HW369_RS24780	COG2224	Isocitrate lyase
HW369_RS24785	COG0501	Belongs to the peptidase M48B family
HW369_RS24935	COG0277	FAD linked oxidase domain protein
HW369_RS25005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW369_RS25015	COG0673	inositol 2-dehydrogenase activity
HW369_RS25070	COG1215	transferase activity, transferring glycosyl groups
HW369_RS25110	COG0438	transferase activity, transferring glycosyl groups
HW369_RS25160	COG1024	Enoyl-CoA hydratase
HW369_RS25165	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS25170	COG0095	Lipoate-protein ligase
HW369_RS25175	COG1234	tRNA 3'-trailer cleavage
HW369_RS25190	COG2972	Histidine kinase
HW369_RS25200	COG0768	penicillin binding
HW369_RS25205	COG1309	transcriptional regulator
HW369_RS25210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW369_RS25215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW369_RS25220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW369_RS25225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW369_RS25230	COG2329	Antibiotic biosynthesis monooxygenase
HW369_RS25235	COG3069	C4-dicarboxylate transmembrane transporter activity
HW369_RS25240	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS25245	COG1473	amidohydrolase
HW369_RS25255	COG4473	ABC transporter
HW369_RS25260	COG1131	(ABC) transporter
HW369_RS25265	COG0537	adenosine 5'-monophosphoramidase activity
HW369_RS25270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW369_RS25270	COG2755	lipolytic protein G-D-S-L family
HW369_RS25275	COG2153	protein acetylation
HW369_RS25280	COG1695	Transcriptional regulator
HW369_RS25285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HW369_RS25300	COG1846	Transcriptional regulator
HW369_RS25325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW369_RS25335	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW369_RS25340	COG1668	transmembrane transport
HW369_RS25345	COG4152	abc transporter atp-binding protein
HW369_RS25360	COG1024	Enoyl-CoA hydratase
HW369_RS25365	COG0318	PFAM AMP-dependent synthetase and ligase
HW369_RS25370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW369_RS25375	COG0561	phosphatase activity
HW369_RS25380	COG3679	Belongs to the UPF0342 family
HW369_RS25390	COG0189	ligase activity
HW369_RS25395	COG0189	ligase activity
HW369_RS25410	COG2508	Transcriptional regulator
HW369_RS25415	COG3842	ATPase activity
HW369_RS25430	COG1253	flavin adenine dinucleotide binding
HW369_RS25435	COG0702	epimerase
HW369_RS25450	COG0351	phosphomethylpyrimidine kinase
HW369_RS25455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW369_RS25470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW369_RS25475	COG0352	thiamine-phosphate diphosphorylase activity
HW369_RS25485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW369_RS25490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW369_RS25495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW369_RS25500	COG0765	amino acid transport
HW369_RS25505	COG1126	abc transporter atp-binding protein
HW369_RS25515	COG0604	alcohol dehydrogenase
HW369_RS25520	COG1959	2 iron, 2 sulfur cluster binding
HW369_RS25530	COG2719	SpoVR family
HW369_RS25540	COG1268	BioY protein
HW369_RS25545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW369_RS25550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW369_RS25560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW369_RS25565	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HW369_RS25570	COG3153	acetyltransferase
HW369_RS25570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW369_RS25575	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS25580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW369_RS25595	COG0564	pseudouridine synthase activity
HW369_RS25600	COG0840	transmembrane signaling receptor activity
HW369_RS25605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW369_RS25615	COG1620	l-lactate permease
HW369_RS25620	COG0604	alcohol dehydrogenase
HW369_RS25635	COG0628	permease
HW369_RS25645	COG2962	Rard protein
HW369_RS25650	COG0084	hydrolase, TatD family'
HW369_RS25665	COG2851	Citrate transporter
HW369_RS25680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW369_RS25685	COG1942	4-Oxalocrotonate Tautomerase
HW369_RS25700	COG1187	pseudouridine synthase activity
HW369_RS25705	COG1309	transcriptional regulator
HW369_RS25710	COG2814	Major facilitator Superfamily
HW369_RS25730	COG1522	sequence-specific DNA binding
HW369_RS25735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS25750	COG1609	Transcriptional regulator
HW369_RS25775	COG0673	inositol 2-dehydrogenase activity
HW369_RS25780	COG2814	Major facilitator Superfamily
HW369_RS25785	COG1609	Transcriptional regulator
HW369_RS25810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW369_RS25815	COG0456	acetyltransferase
HW369_RS25815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW369_RS25825	COG3103	Sh3 type 3 domain protein
HW369_RS25835	COG1876	peptidase activity
HW369_RS25840	COG3583	domain protein
HW369_RS25840	COG3584	3D domain protein
HW369_RS25870	COG4948	Mandelate Racemase Muconate Lactonizing
HW369_RS25885	COG0584	glycerophosphoryl diester phosphodiesterase
HW369_RS25900	COG1175	transmembrane transport
HW369_RS25905	COG3842	ATPase activity
HW369_RS25910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HW369_RS25915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HW369_RS25930	COG0531	amino acid
HW369_RS25935	COG2217	Heavy metal translocating P-type atpase
HW369_RS25940	COG0586	Pfam SNARE associated Golgi protein
HW369_RS25945	COG0628	permease
HW369_RS25950	COG1301	dicarboxylic acid transport
HW369_RS25955	COG1968	undecaprenyl-diphosphatase activity
HW369_RS25965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HW369_RS25975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW369_RS25990	COG2766	serine protein kinase
HW369_RS25995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW369_RS26010	COG3382	B3 4 domain protein
HW369_RS26115	COG0735	belongs to the Fur family
HW369_RS26120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW369_RS26140	COG4555	ABC transporter
HW369_RS26145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW369_RS26150	COG4129	membrane
HW369_RS26155	COG1132	(ABC) transporter
HW369_RS26160	COG3557	Belongs to the UPF0374 family
HW369_RS26175	COG1028	Short-chain dehydrogenase reductase Sdr
HW369_RS26185	COG1194	a g-specific adenine glycosylase
HW369_RS26190	COG1988	membrane-bound metal-dependent
HW369_RS26210	COG4221	oxidoreductase activity
HW369_RS26220	COG1090	epimerase
HW369_RS26240	COG5002	protein histidine kinase activity
HW369_RS26245	COG1113	amino acid transport
HW369_RS26250	COG0277	FAD linked oxidase domain protein
HW369_RS26255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW369_RS26275	COG0535	radical SAM domain protein
HW369_RS26285	COG0387	Pfam Sodium calcium exchanger
HW369_RS26290	COG3871	stress protein (general stress protein 26)
HW369_RS26300	COG3479	Phenolic acid decarboxylase
HW369_RS26305	COG0477	Major facilitator Superfamily
HW369_RS26315	COG0640	Transcriptional regulator
HW369_RS26325	COG2217	Heavy metal translocating P-type atpase
HW369_RS26330	COG1295	ribonuclease BN
HW369_RS26335	COG4980	gas vesicle protein
HW369_RS26340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW369_RS26345	COG4840	Belongs to the UPF0435 family
HW369_RS26350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW369_RS26355	COG2340	Cysteine-rich secretory protein family
HW369_RS26360	COG0693	protein deglycase activity
HW369_RS26370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW369_RS26370	COG1017	nitric oxide dioxygenase activity
HW369_RS26375	COG1959	2 iron, 2 sulfur cluster binding
HW369_RS26385	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HW369_RS26395	COG0488	(ABC) transporter
HW369_RS26410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW369_RS26420	COG2356	endonuclease I
HW369_RS26435	COG1511	domain protein
HW369_RS26440	COG0433	COG0433 Predicted ATPase
HW369_RS26440	COG1674	ftsk spoiiie
HW369_RS26445	COG4499	WXG100 protein secretion system (Wss), protein YukC
HW369_RS26450	COG5417	Belongs to the EsaB family
HW369_RS26455	COG4842	Belongs to the WXG100 family
HW369_RS26475	COG0513	Belongs to the DEAD box helicase family
HW369_RS26480	COG4191	Histidine kinase
HW369_RS26495	COG4565	transcriptional regulatory protein
HW369_RS26500	COG3290	protein histidine kinase activity
HW369_RS26505	COG0598	Magnesium transport protein CorA
HW369_RS26510	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HW369_RS26525	COG1115	amino acid carrier protein
HW369_RS26535	COG2318	DinB family
HW369_RS26540	COG0693	protein deglycase activity
HW369_RS26545	COG2259	Doxx family
HW369_RS26555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HW369_RS26560	COG1764	response to oxidative stress
HW369_RS26565	COG0671	phosphoesterase, PA-phosphatase related
HW369_RS26580	COG2311	Membrane
HW369_RS26585	COG0745	RESPONSE REGULATOR receiver
HW369_RS26590	COG2205	protein histidine kinase activity
HW369_RS26595	COG0745	RESPONSE REGULATOR receiver
HW369_RS26600	COG3850	Histidine kinase
HW369_RS26600	COG5002	protein histidine kinase activity
HW369_RS26605	COG3212	peptidase
HW369_RS26610	COG3212	peptidase
HW369_RS26615	COG2733	membrane
HW369_RS26620	COG1113	amino acid transport
HW369_RS26625	COG0765	amino acid transport
HW369_RS26630	COG0765	amino acid transport
HW369_RS26635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW369_RS26640	COG1126	abc transporter atp-binding protein
HW369_RS26645	COG1876	peptidase activity
HW369_RS26655	COG2814	Major facilitator Superfamily
HW369_RS26660	COG0789	Transcriptional regulator
HW369_RS26660	COG4978	Transcriptional regulator
HW369_RS26670	COG2706	6-phosphogluconolactonase activity
HW369_RS26675	COG0024	Methionine aminopeptidase
HW369_RS26680	COG3852	Histidine kinase
HW369_RS26685	COG1744	ABC transporter substrate-binding protein PnrA-like
HW369_RS26690	COG0166	Belongs to the GPI family
HW369_RS26700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW369_RS26710	COG1597	lipid kinase activity
HW369_RS26720	COG0154	amidase activity
HW369_RS26725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW369_RS26735	COG4851	CamS sex pheromone cAM373 precursor
HW369_RS26745	COG0210	DNA helicase
HW369_RS26755	COG0423	glycine-tRNA ligase activity
HW369_RS26760	COG4496	protein, YerC YecD
HW369_RS26765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW369_RS26775	COG0151	Belongs to the GarS family
HW369_RS26780	COG0138	bifunctional purine biosynthesis protein purh
HW369_RS26785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW369_RS26790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW369_RS26795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW369_RS26800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW369_RS26805	COG0047	phosphoribosylformylglycinamidine synthase activity
HW369_RS26810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW369_RS26815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW369_RS26820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW369_RS26825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW369_RS26830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW369_RS26840	COG2252	PERMEase
HW369_RS26845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW369_RS26845	COG0519	Catalyzes the synthesis of GMP from XMP
HW369_RS26850	COG1305	Transglutaminase-like
HW369_RS26855	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HW369_RS26860	COG0714	Associated with various cellular activities
HW369_RS26865	COG0459	protein refolding
HW369_RS26870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW369_RS26875	COG1266	CAAX protease self-immunity
HW369_RS26885	COG0805	protein transport
HW369_RS26890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW369_RS26895	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HW369_RS26900	COG0488	(ABC) transporter
HW369_RS26910	COG0456	acetyltransferase
HW369_RS26915	COG1214	PFAM Peptidase M22, glycoprotease
HW369_RS26920	COG0802	atpase or kinase
HW369_RS27005	COG2183	response to ionizing radiation
HW369_RS27010	COG2208	phosphoserine phosphatase activity
HW369_RS27015	COG1191	sigma factor activity
HW369_RS27025	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS27030	COG2208	phosphoserine phosphatase activity
HW369_RS27035	COG2172	sigma factor antagonist activity
HW369_RS27040	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS27045	COG1366	Belongs to the anti-sigma-factor antagonist family
HW369_RS27050	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW369_RS27055	COG0864	Transcriptional regulator
HW369_RS27065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HW369_RS27070	COG0736	holo-[acyl-carrier-protein] synthase activity
HW369_RS27075	COG0705	Rhomboid family
HW369_RS27080	COG4294	response to UV
HW369_RS27085	COG0513	Belongs to the DEAD box helicase family
HW369_RS27090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW369_RS27095	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW369_RS27105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW369_RS27110	COG1177	transmembrane transport
HW369_RS27130	COG1368	sulfuric ester hydrolase activity
HW369_RS27135	COG1970	mechanosensitive ion channel activity
HW369_RS27140	COG1376	ErfK ybiS ycfS ynhG family protein
HW369_RS27150	COG0246	Mannitol dehydrogenase
HW369_RS27155	COG3711	transcriptional antiterminator
HW369_RS27160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW369_RS27160	COG2213	PTS system mannitol-specific
HW369_RS27175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW369_RS27180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW369_RS27190	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW369_RS27195	COG5662	AntiSigma factor
HW369_RS27200	COG1595	DNA-templated transcription, initiation
HW369_RS27255	COG0726	polysaccharide deacetylase
HW369_RS27260	COG2194	sulfuric ester hydrolase activity
HW369_RS27270	COG0583	DNA-binding transcription factor activity
HW369_RS27275	COG0489	protein tyrosine kinase activity
HW369_RS27280	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW369_RS27295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW369_RS27300	COG0101	tRNA pseudouridine synthase activity
HW369_RS27305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW369_RS27310	COG1122	ATPase activity
HW369_RS27315	COG1122	ATPase activity
HW369_RS27320	COG0203	ribosomal protein L17
HW369_RS27325	COG0202	RNA polymerase activity
HW369_RS27335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW369_RS27340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW369_RS27345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW369_RS27350	COG0024	Methionine aminopeptidase
HW369_RS27355	COG0563	adenylate kinase activity
HW369_RS27360	COG0201	protein transport
HW369_RS27370	COG1841	ribosomal large subunit assembly
HW369_RS27375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW369_RS27380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW369_RS27390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW369_RS27395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW369_RS27410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW369_RS27415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW369_RS27420	COG0255	Belongs to the universal ribosomal protein uL29 family
HW369_RS27425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW369_RS27435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW369_RS27440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW369_RS27445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW369_RS27450	COG0089	rRNA binding
HW369_RS27455	COG0088	Forms part of the polypeptide exit tunnel
HW369_RS27460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW369_RS27465	COG0051	transcription antitermination factor activity, RNA binding
HW369_RS27470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW369_RS27480	COG0049	tRNA binding
HW369_RS27485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW369_RS27490	COG1358	cellular component organization or biogenesis
HW369_RS27495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW369_RS27500	COG0085	RNA polymerase activity
HW369_RS27505	COG2813	Specifically methylates the guanine in position
HW369_RS27510	COG0222	ribosome binding
HW369_RS27515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW369_RS27520	COG0081	regulation of translation
HW369_RS27525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW369_RS27530	COG0250	Participates in transcription elongation, termination and antitermination
HW369_RS27535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW369_RS27540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW369_RS27550	COG3688	RNA-binding protein containing a PIN domain
HW369_RS27555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW369_RS27565	COG0215	cysteine-tRNA ligase activity
HW369_RS27570	COG1045	serine acetyltransferase
HW369_RS27575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW369_RS27585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW369_RS27590	COG4956	integral membrane protein (PIN domain superfamily)
HW369_RS27595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HW369_RS27600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW369_RS27605	COG0542	response to heat
HW369_RS27610	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HW369_RS27615	COG3880	PFAM UvrB UvrC protein
HW369_RS27625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW369_RS27630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW369_RS27635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW369_RS27640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW369_RS27645	COG0512	Glutamine amidotransferase of anthranilate synthase
HW369_RS27650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW369_RS27655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW369_RS27660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HW369_RS27665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HW369_RS27670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW369_RS27680	COG0515	serine threonine protein kinase
HW369_RS27685	COG2304	oxidoreductase activity
HW369_RS27705	COG1098	S1 RNA binding domain
HW369_RS27710	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HW369_RS27725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW369_RS27730	COG3956	TIGRFAM MazG family protein
HW369_RS27735	COG2244	polysaccharide biosynthetic process
HW369_RS27740	COG2002	toxin-antitoxin pair type II binding
HW369_RS27745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW369_RS27755	COG0193	aminoacyl-tRNA hydrolase activity
HW369_RS27760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW369_RS27770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW369_RS27775	COG2088	sporulation resulting in formation of a cellular spore
HW369_RS27780	COG0251	oxidation-reduction process
HW369_RS27785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW369_RS27800	COG4466	Protein conserved in bacteria
HW369_RS27810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW369_RS27820	COG0084	hydrolase, TatD family'
HW369_RS27830	COG2002	toxin-antitoxin pair type II binding
HW369_RS27835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW369_RS27840	COG2827	Endonuclease containing a URI domain
HW369_RS27845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HW369_RS27850	COG4467	Involved in initiation control of chromosome replication
HW369_RS27855	COG1774	PSP1 C-terminal conserved region
HW369_RS27860	COG0470	DNA polymerase III
HW369_RS27865	COG3870	Protein conserved in bacteria
HW369_RS27870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW369_RS27875	COG1982	Orn Lys Arg decarboxylase major
HW369_RS27920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW369_RS27925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HW369_RS27930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW369_RS27940	COG0590	tRNA wobble adenosine to inosine editing
HW369_RS27945	COG1335	isochorismatase
HW369_RS27950	COG1388	LysM domain
HW369_RS27950	COG3858	chitin binding
HW369_RS27955	COG1428	Deoxynucleoside kinase
HW369_RS27960	COG1428	Deoxynucleoside kinase
HW369_RS27975	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW369_RS27990	COG0516	GMP reductase activity
HW369_RS27990	COG0517	IMP dehydrogenase activity