locus-tag	class	description
AS52_RS00090	COG1982	Orn Lys Arg decarboxylase major
AS52_RS00095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AS52_RS00100	COG3870	Protein conserved in bacteria
AS52_RS00105	COG0470	DNA polymerase III
AS52_RS00110	COG1774	PSP1 C-terminal conserved region
AS52_RS00115	COG4467	Involved in initiation control of chromosome replication
AS52_RS00120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AS52_RS00125	COG2827	Endonuclease containing a URI domain
AS52_RS00130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AS52_RS00135	COG2002	toxin-antitoxin pair type II binding
AS52_RS00145	COG0084	hydrolase, TatD family'
AS52_RS00155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS52_RS00165	COG4466	Protein conserved in bacteria
AS52_RS00180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_RS00185	COG0251	oxidation-reduction process
AS52_RS00190	COG2088	sporulation resulting in formation of a cellular spore
AS52_RS00195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS52_RS00205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS52_RS00210	COG0193	aminoacyl-tRNA hydrolase activity
AS52_RS00220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS52_RS00225	COG2002	toxin-antitoxin pair type II binding
AS52_RS00230	COG2244	polysaccharide biosynthetic process
AS52_RS00235	COG3956	TIGRFAM MazG family protein
AS52_RS00240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS52_RS00255	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AS52_RS00260	COG1098	S1 RNA binding domain
AS52_RS00280	COG2304	oxidoreductase activity
AS52_RS00285	COG0515	serine threonine protein kinase
AS52_RS00290	COG0037	tRNA processing
AS52_RS00295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AS52_RS00300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS52_RS00305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AS52_RS00310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AS52_RS00315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_RS00320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AS52_RS00325	COG0512	Glutamine amidotransferase of anthranilate synthase
AS52_RS00330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS52_RS00335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS52_RS00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS52_RS00345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AS52_RS00370	COG3880	PFAM UvrB UvrC protein
AS52_RS00375	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AS52_RS00380	COG0542	response to heat
AS52_RS00385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AS52_RS00390	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AS52_RS00395	COG4956	integral membrane protein (PIN domain superfamily)
AS52_RS00400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AS52_RS00410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS52_RS00415	COG1045	serine acetyltransferase
AS52_RS00420	COG0215	cysteine-tRNA ligase activity
AS52_RS00430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS52_RS00435	COG3688	RNA-binding protein containing a PIN domain
AS52_RS00445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS52_RS00450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS52_RS00455	COG0250	Participates in transcription elongation, termination and antitermination
AS52_RS00460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AS52_RS00465	COG0081	regulation of translation
AS52_RS00470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AS52_RS00475	COG0222	ribosome binding
AS52_RS00480	COG2813	Specifically methylates the guanine in position
AS52_RS00485	COG0085	RNA polymerase activity
AS52_RS00490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS52_RS00495	COG1358	cellular component organization or biogenesis
AS52_RS00500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS52_RS00505	COG0049	tRNA binding
AS52_RS00515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS52_RS00520	COG0051	transcription antitermination factor activity, RNA binding
AS52_RS00525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS52_RS00530	COG0088	Forms part of the polypeptide exit tunnel
AS52_RS00535	COG0089	rRNA binding
AS52_RS00540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AS52_RS00545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS52_RS00550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS52_RS00560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AS52_RS00565	COG0255	Belongs to the universal ribosomal protein uL29 family
AS52_RS00570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AS52_RS00575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS52_RS00590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS52_RS00605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AS52_RS00610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS52_RS00615	COG1841	ribosomal large subunit assembly
AS52_RS00625	COG0201	protein transport
AS52_RS00630	COG0563	adenylate kinase activity
AS52_RS00635	COG0024	Methionine aminopeptidase
AS52_RS00640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS52_RS00645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS52_RS00650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AS52_RS00660	COG0202	RNA polymerase activity
AS52_RS00665	COG0203	ribosomal protein L17
AS52_RS00670	COG1122	ATPase activity
AS52_RS00675	COG1122	ATPase activity
AS52_RS00680	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS52_RS00685	COG0101	tRNA pseudouridine synthase activity
AS52_RS00690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS52_RS00705	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS00710	COG0489	protein tyrosine kinase activity
AS52_RS00715	COG0583	DNA-binding transcription factor activity
AS52_RS00725	COG2194	sulfuric ester hydrolase activity
AS52_RS00730	COG0726	polysaccharide deacetylase
AS52_RS00805	COG1595	DNA-templated transcription, initiation
AS52_RS00810	COG5662	AntiSigma factor
AS52_RS00815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS52_RS00825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS52_RS00830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS52_RS00845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS00845	COG2213	PTS system mannitol-specific
AS52_RS00850	COG3711	transcriptional antiterminator
AS52_RS00855	COG0246	Mannitol dehydrogenase
AS52_RS00865	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS00870	COG1970	mechanosensitive ion channel activity
AS52_RS00875	COG1368	sulfuric ester hydrolase activity
AS52_RS00895	COG1177	transmembrane transport
AS52_RS00900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AS52_RS00910	COG0745	RESPONSE REGULATOR receiver
AS52_RS00915	COG5002	protein histidine kinase activity
AS52_RS00930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AS52_RS00930	COG3976	FMN-binding domain protein
AS52_RS00935	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS52_RS00940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS52_RS00945	COG0513	Belongs to the DEAD box helicase family
AS52_RS00950	COG4294	response to UV
AS52_RS00955	COG0705	Rhomboid family
AS52_RS00960	COG0736	holo-[acyl-carrier-protein] synthase activity
AS52_RS00965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS52_RS00970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS52_RS00975	COG0864	Transcriptional regulator
AS52_RS00980	COG2337	Toxic component of a toxin-antitoxin (TA) module
AS52_RS00985	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS00990	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS00995	COG2172	sigma factor antagonist activity
AS52_RS01000	COG2208	phosphoserine phosphatase activity
AS52_RS01005	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS01015	COG1191	sigma factor activity
AS52_RS01020	COG2208	phosphoserine phosphatase activity
AS52_RS01025	COG2183	response to ionizing radiation
AS52_RS01115	COG0802	atpase or kinase
AS52_RS01120	COG1214	PFAM Peptidase M22, glycoprotease
AS52_RS01125	COG0456	acetyltransferase
AS52_RS01135	COG0488	(ABC) transporter
AS52_RS01140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AS52_RS01145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_RS01150	COG0805	protein transport
AS52_RS01160	COG1266	CAAX protease self-immunity
AS52_RS01165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AS52_RS01170	COG0459	protein refolding
AS52_RS01175	COG4974	Belongs to the 'phage' integrase family
AS52_RS01245	COG0714	Associated with various cellular activities
AS52_RS01250	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AS52_RS01255	COG1305	Transglutaminase-like
AS52_RS01260	COG0519	Catalyzes the synthesis of GMP from XMP
AS52_RS01260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS52_RS01265	COG2252	PERMEase
AS52_RS01320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS52_RS01325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS52_RS01330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS52_RS01335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AS52_RS01340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS52_RS01345	COG0047	phosphoribosylformylglycinamidine synthase activity
AS52_RS01350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS52_RS01355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AS52_RS01360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AS52_RS01365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS52_RS01370	COG0138	bifunctional purine biosynthesis protein purh
AS52_RS01375	COG0151	Belongs to the GarS family
AS52_RS01385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS52_RS01390	COG4496	protein, YerC YecD
AS52_RS01395	COG0423	glycine-tRNA ligase activity
AS52_RS01405	COG0210	DNA helicase
AS52_RS01415	COG4851	CamS sex pheromone cAM373 precursor
AS52_RS01425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS52_RS01430	COG0154	amidase activity
AS52_RS01440	COG1597	lipid kinase activity
AS52_RS01455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS01465	COG0166	Belongs to the GPI family
AS52_RS01470	COG1744	ABC transporter substrate-binding protein PnrA-like
AS52_RS01475	COG3852	Histidine kinase
AS52_RS01480	COG0024	Methionine aminopeptidase
AS52_RS01485	COG2706	6-phosphogluconolactonase activity
AS52_RS01495	COG4978	Transcriptional regulator
AS52_RS01495	COG0789	Transcriptional regulator
AS52_RS01500	COG2814	Major facilitator Superfamily
AS52_RS01510	COG1876	peptidase activity
AS52_RS01515	COG1126	abc transporter atp-binding protein
AS52_RS01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_RS01525	COG0765	amino acid transport
AS52_RS01530	COG0765	amino acid transport
AS52_RS01535	COG1113	amino acid transport
AS52_RS01540	COG2733	membrane
AS52_RS01545	COG3212	peptidase
AS52_RS01550	COG3212	peptidase
AS52_RS01555	COG3850	Histidine kinase
AS52_RS01555	COG5002	protein histidine kinase activity
AS52_RS01560	COG0745	RESPONSE REGULATOR receiver
AS52_RS01565	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS01570	COG1764	response to oxidative stress
AS52_RS01575	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AS52_RS01585	COG2259	Doxx family
AS52_RS01590	COG0693	protein deglycase activity
AS52_RS01595	COG2318	DinB family
AS52_RS01605	COG1115	amino acid carrier protein
AS52_RS01620	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AS52_RS01625	COG0598	Magnesium transport protein CorA
AS52_RS01630	COG3290	protein histidine kinase activity
AS52_RS01635	COG4565	transcriptional regulatory protein
AS52_RS01650	COG4191	Histidine kinase
AS52_RS01655	COG0513	Belongs to the DEAD box helicase family
AS52_RS01675	COG4842	Belongs to the WXG100 family
AS52_RS01680	COG5417	Belongs to the EsaB family
AS52_RS01685	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS52_RS01690	COG0433	COG0433 Predicted ATPase
AS52_RS01690	COG1674	ftsk spoiiie
AS52_RS01695	COG1511	domain protein
AS52_RS01710	COG2356	endonuclease I
AS52_RS01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_RS01735	COG0488	(ABC) transporter
AS52_RS01745	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AS52_RS01755	COG1959	2 iron, 2 sulfur cluster binding
AS52_RS01760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS52_RS01760	COG1017	nitric oxide dioxygenase activity
AS52_RS01770	COG0693	protein deglycase activity
AS52_RS01775	COG2340	Cysteine-rich secretory protein family
AS52_RS01780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS52_RS01785	COG4840	Belongs to the UPF0435 family
AS52_RS01790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS52_RS01795	COG4980	gas vesicle protein
AS52_RS01800	COG1295	ribonuclease BN
AS52_RS01805	COG2217	Heavy metal translocating P-type atpase
AS52_RS01815	COG0640	Transcriptional regulator
AS52_RS01825	COG0477	Major facilitator Superfamily
AS52_RS01835	COG3479	Phenolic acid decarboxylase
AS52_RS01845	COG3871	stress protein (general stress protein 26)
AS52_RS01850	COG0387	Pfam Sodium calcium exchanger
AS52_RS01860	COG0535	radical SAM domain protein
AS52_RS01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_RS01885	COG0277	FAD linked oxidase domain protein
AS52_RS01890	COG1113	amino acid transport
AS52_RS01895	COG5002	protein histidine kinase activity
AS52_RS01910	COG1090	epimerase
AS52_RS01920	COG4221	oxidoreductase activity
AS52_RS01940	COG1988	membrane-bound metal-dependent
AS52_RS01945	COG1194	a g-specific adenine glycosylase
AS52_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS01970	COG3557	Belongs to the UPF0374 family
AS52_RS01975	COG1132	(ABC) transporter
AS52_RS01980	COG4129	membrane
AS52_RS01985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS52_RS01990	COG4555	ABC transporter
AS52_RS02010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS52_RS02015	COG0735	belongs to the Fur family
AS52_RS02130	COG3382	B3 4 domain protein
AS52_RS02145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS52_RS02150	COG2766	serine protein kinase
AS52_RS02165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_RS02170	COG0697	spore germination
AS52_RS02195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AS52_RS02205	COG1968	undecaprenyl-diphosphatase activity
AS52_RS02210	COG1301	dicarboxylic acid transport
AS52_RS02215	COG0628	permease
AS52_RS02220	COG0586	Pfam SNARE associated Golgi protein
AS52_RS02225	COG2217	Heavy metal translocating P-type atpase
AS52_RS02235	COG0531	amino acid
AS52_RS02250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AS52_RS02255	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS52_RS02260	COG3842	ATPase activity
AS52_RS02265	COG1175	transmembrane transport
AS52_RS02270	COG0395	ABC-type sugar transport system, permease component
AS52_RS02275	COG1653	transport
AS52_RS02280	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_RS02295	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_RS02340	COG1388	LysM domain
AS52_RS02340	COG3584	3D domain protein
AS52_RS02345	COG1876	peptidase activity
AS52_RS02350	COG3103	Sh3 type 3 domain protein
AS52_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS02355	COG0456	acetyltransferase
AS52_RS02365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS02390	COG1609	Transcriptional regulator
AS52_RS02395	COG2814	Major facilitator Superfamily
AS52_RS02400	COG0673	inositol 2-dehydrogenase activity
AS52_RS02425	COG1609	Transcriptional regulator
AS52_RS02430	COG3718	enzyme involved in inositol metabolism
AS52_RS02440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS02445	COG1522	sequence-specific DNA binding
AS52_RS02465	COG2814	Major facilitator Superfamily
AS52_RS02470	COG1187	pseudouridine synthase activity
AS52_RS02480	COG1942	4-Oxalocrotonate Tautomerase
AS52_RS02490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS52_RS02495	COG0747	negative chemotaxis
AS52_RS02510	COG0084	hydrolase, TatD family'
AS52_RS02515	COG2962	Rard protein
AS52_RS02525	COG0628	permease
AS52_RS02540	COG0604	alcohol dehydrogenase
AS52_RS02545	COG1620	l-lactate permease
AS52_RS02555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_RS02560	COG0840	transmembrane signaling receptor activity
AS52_RS02565	COG0564	pseudouridine synthase activity
AS52_RS02580	COG0673	inositol 2-dehydrogenase activity
AS52_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_RS02590	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS02595	COG3153	acetyltransferase
AS52_RS02595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS02600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS52_RS02605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS52_RS02615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS52_RS02620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS52_RS02625	COG1268	BioY protein
AS52_RS02635	COG2719	SpoVR family
AS52_RS02645	COG1959	2 iron, 2 sulfur cluster binding
AS52_RS02650	COG0604	alcohol dehydrogenase
AS52_RS02660	COG1126	abc transporter atp-binding protein
AS52_RS02665	COG0765	amino acid transport
AS52_RS02670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_RS02675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS52_RS02680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS52_RS02690	COG0352	thiamine-phosphate diphosphorylase activity
AS52_RS02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_RS02710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_RS02715	COG0351	phosphomethylpyrimidine kinase
AS52_RS02730	COG0702	epimerase
AS52_RS02735	COG1253	flavin adenine dinucleotide binding
AS52_RS02750	COG3842	ATPase activity
AS52_RS02755	COG2508	Transcriptional regulator
AS52_RS02770	COG0189	ligase activity
AS52_RS02775	COG0189	ligase activity
AS52_RS02785	COG3679	Belongs to the UPF0342 family
AS52_RS02790	COG0561	phosphatase activity
AS52_RS02795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS52_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS02805	COG1024	Enoyl-CoA hydratase
AS52_RS02820	COG4152	abc transporter atp-binding protein
AS52_RS02825	COG1668	transmembrane transport
AS52_RS02830	COG3481	metal-dependent phosphohydrolase, HD sub domain
AS52_RS02840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_RS02855	COG1846	Transcriptional regulator
AS52_RS02870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AS52_RS02875	COG1695	Transcriptional regulator
AS52_RS02880	COG2153	protein acetylation
AS52_RS02885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS52_RS02885	COG2755	lipolytic protein G-D-S-L family
AS52_RS02890	COG0537	adenosine 5'-monophosphoramidase activity
AS52_RS02895	COG1131	(ABC) transporter
AS52_RS02900	COG4473	ABC transporter
AS52_RS02910	COG1473	amidohydrolase
AS52_RS02915	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS02920	COG3069	C4-dicarboxylate transmembrane transporter activity
AS52_RS02925	COG2329	Antibiotic biosynthesis monooxygenase
AS52_RS02930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_RS02935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS52_RS02940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AS52_RS02945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AS52_RS02950	COG1309	transcriptional regulator
AS52_RS02955	COG0768	penicillin binding
AS52_RS02965	COG2972	Histidine kinase
AS52_RS02975	COG1234	tRNA 3'-trailer cleavage
AS52_RS02980	COG0095	Lipoate-protein ligase
AS52_RS02985	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS02990	COG1024	Enoyl-CoA hydratase
AS52_RS03105	COG0501	Belongs to the peptidase M48B family
AS52_RS03110	COG2224	Isocitrate lyase
AS52_RS03120	COG0823	Involved in the tonB-independent uptake of proteins
AS52_RS03120	COG4946	Tricorn protease homolog
AS52_RS03120	COG1506	peptidase
AS52_RS03125	COG0398	Pfam SNARE associated Golgi protein
AS52_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS03135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AS52_RS03140	COG1074	ATP-dependent DNA helicase activity
AS52_RS03145	COG0420	3'-5' exonuclease activity
AS52_RS03150	COG0419	ATPase involved in DNA repair
AS52_RS03155	COG1403	HNH endonuclease
AS52_RS03190	COG2311	Membrane
AS52_RS03205	COG0367	asparagine synthase
AS52_RS03220	COG1562	ergosterol biosynthetic process
AS52_RS03225	COG0347	Belongs to the P(II) protein family
AS52_RS03230	COG0004	ammonium transporteR
AS52_RS03235	COG1874	Beta-galactosidase
AS52_RS03235	COG0366	Alpha amylase catalytic
AS52_RS03240	COG1609	Transcriptional regulator
AS52_RS03245	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS03250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS52_RS03255	COG4187	Peptidase family M20/M25/M40
AS52_RS03260	COG0833	amino acid
AS52_RS03265	COG3829	transcription factor binding
AS52_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS03275	COG1666	GTP binding
AS52_RS03280	COG2996	Protein conserved in bacteria
AS52_RS03285	COG1307	EDD domain protein, DegV family
AS52_RS03290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS03300	COG0561	phosphatase activity
AS52_RS03305	COG2151	metal-sulfur cluster biosynthetic enzyme
AS52_RS03310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS52_RS03315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AS52_RS03320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS52_RS03325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS52_RS03345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS52_RS03360	COG0542	response to heat
AS52_RS03375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AS52_RS03380	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AS52_RS03385	COG2084	Dehydrogenase
AS52_RS03395	COG2267	carboxylic ester hydrolase activity
AS52_RS03415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS52_RS03420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS52_RS03425	COG5504	Zn-dependent protease
AS52_RS03430	COG0444	Belongs to the ABC transporter superfamily
AS52_RS03435	COG4608	Belongs to the ABC transporter superfamily
AS52_RS03445	COG0601	transmembrane transport
AS52_RS03460	COG0180	Tryptophanyl-tRNA synthetase
AS52_RS03470	COG4166	transmembrane transport
AS52_RS03475	COG0601	transmembrane transport
AS52_RS03480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_RS03485	COG0444	Belongs to the ABC transporter superfamily
AS52_RS03490	COG4608	Belongs to the ABC transporter superfamily
AS52_RS03495	COG0456	acetyltransferase
AS52_RS03500	COG1113	amino acid transport
AS52_RS03505	COG0531	amino acid
AS52_RS03510	COG1393	Belongs to the ArsC family
AS52_RS03515	COG0583	DNA-binding transcription factor activity
AS52_RS03530	COG0861	Integral membrane protein TerC family
AS52_RS03540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS03550	COG1164	Oligoendopeptidase f
AS52_RS03560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS52_RS03565	COG2346	COG2346, Truncated hemoglobins
AS52_RS03570	COG0741	lytic transglycosylase activity
AS52_RS03575	COG4116	CYTH
AS52_RS03585	COG2357	RelA SpoT domain protein
AS52_RS03595	COG0564	pseudouridine synthase activity
AS52_RS03605	COG2239	Acts as a magnesium transporter
AS52_RS03610	COG0569	domain protein
AS52_RS03610	COG0475	glutathione-regulated potassium exporter activity
AS52_RS03655	COG0210	DNA helicase
AS52_RS03665	COG2323	membrane
AS52_RS03670	COG2153	protein acetylation
AS52_RS03680	COG2382	esterase
AS52_RS03695	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS52_RS03705	COG1737	Transcriptional regulator
AS52_RS03710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_RS03715	COG1070	Carbohydrate kinase
AS52_RS03720	COG1953	Uracil, thiamine, allantoin
AS52_RS03740	COG1522	sequence-specific DNA binding
AS52_RS03760	COG1131	(ABC) transporter
AS52_RS03780	COG3142	Participates in the control of copper homeostasis
AS52_RS03790	COG1113	amino acid transport
AS52_RS03800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS03805	COG1309	transcriptional regulator
AS52_RS03810	COG3711	transcriptional antiterminator
AS52_RS03810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS03815	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_RS03820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_RS03825	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_RS03830	COG1486	melibiose metabolic process
AS52_RS03835	COG2204	response regulator
AS52_RS03850	COG3275	phosphorelay sensor kinase activity
AS52_RS03855	COG3279	Response regulator of the LytR AlgR family
AS52_RS03865	COG1346	cytolysis
AS52_RS03880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_RS03885	COG0243	molybdopterin cofactor binding
AS52_RS03890	COG2223	nitrite transmembrane transporter activity
AS52_RS03895	COG3527	Alpha-acetolactate decarboxylase
AS52_RS03900	COG0028	Belongs to the TPP enzyme family
AS52_RS03905	COG4895	conserved protein (DUF2196)
AS52_RS03915	COG1733	regulation of RNA biosynthetic process
AS52_RS03920	COG2814	Major facilitator Superfamily
AS52_RS03925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS03945	COG3052	prosthetic group binding
AS52_RS03960	COG0784	Response regulator, receiver
AS52_RS03965	COG4191	Histidine kinase
AS52_RS03970	COG2066	Belongs to the glutaminase family
AS52_RS03975	COG1115	amino acid carrier protein
AS52_RS03980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_RS03990	COG4297	protein containing double-stranded beta helix domain
AS52_RS03995	COG0531	amino acid
AS52_RS04005	COG1607	acyl-coa hydrolase
AS52_RS04010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS52_RS04025	COG0390	transport system, permease component
AS52_RS04030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS52_RS04045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS52_RS04050	COG1136	(ABC) transporter
AS52_RS04055	COG0577	efflux transmembrane transporter activity
AS52_RS04065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS52_RS04080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_RS04085	COG0833	amino acid
AS52_RS04095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AS52_RS04100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_RS04110	COG0861	Integral membrane protein TerC family
AS52_RS04115	COG1301	dicarboxylic acid transport
AS52_RS04120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AS52_RS04125	COG3290	protein histidine kinase activity
AS52_RS04160	COG0523	cobalamin synthesis protein
AS52_RS04180	COG1063	alcohol dehydrogenase
AS52_RS04205	COG1476	TRANSCRIPTIONal
AS52_RS04215	COG1368	sulfuric ester hydrolase activity
AS52_RS04230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS04235	COG2040	homocysteine
AS52_RS04240	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS52_RS04255	COG2851	Citrate transporter
AS52_RS04260	COG3290	protein histidine kinase activity
AS52_RS04265	COG4565	transcriptional regulatory protein
AS52_RS04270	COG3181	Tripartite tricarboxylate transporter family receptor
AS52_RS04275	COG0583	DNA-binding transcription factor activity
AS52_RS04280	COG3180	Ammonia monooxygenase
AS52_RS04285	COG2226	methyltransferase
AS52_RS04290	COG4176	ABC-type proline glycine betaine transport system permease component
AS52_RS04295	COG0517	IMP dehydrogenase activity
AS52_RS04295	COG4175	Glycine betaine
AS52_RS04300	COG2113	Glycine betaine
AS52_RS04305	COG1309	transcriptional regulator
AS52_RS04310	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS04325	COG0531	amino acid
AS52_RS04330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS52_RS04345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS04355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS52_RS04360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS04365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS04395	COG1737	Transcriptional regulator
AS52_RS04400	COG1263	PTS System
AS52_RS04400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS04415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS52_RS04420	COG2271	Major facilitator Superfamily
AS52_RS04425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_RS04430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS52_RS04435	COG1116	anion transmembrane transporter activity
AS52_RS04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_RS04445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_RS04455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS52_RS04460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AS52_RS04465	COG1733	regulation of RNA biosynthetic process
AS52_RS04500	COG1511	domain protein
AS52_RS04505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS52_RS04510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS52_RS04515	COG1733	regulation of RNA biosynthetic process
AS52_RS04525	COG1132	(ABC) transporter
AS52_RS04530	COG1132	(ABC) transporter
AS52_RS04540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_RS04545	COG3162	membrane
AS52_RS04555	COG1414	Transcriptional regulator
AS52_RS04560	COG0656	L-ascorbic acid biosynthetic process
AS52_RS04565	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AS52_RS04570	COG1846	Transcriptional regulator
AS52_RS04575	COG1566	PFAM secretion protein HlyD family protein
AS52_RS04580	COG2814	Major facilitator Superfamily
AS52_RS04585	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS52_RS04600	COG1609	Transcriptional regulator
AS52_RS04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_RS04615	COG1129	ABC transporter
AS52_RS04620	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS52_RS04625	COG1879	ABC-type sugar transport system periplasmic component
AS52_RS04630	COG1388	LysM domain
AS52_RS04630	COG3584	3D domain protein
AS52_RS04635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS52_RS04640	COG1653	transport
AS52_RS04685	COG0745	RESPONSE REGULATOR receiver
AS52_RS04690	COG5002	protein histidine kinase activity
AS52_RS04700	COG2267	carboxylic ester hydrolase activity
AS52_RS04710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS52_RS04725	COG0402	S-adenosylhomocysteine deaminase activity
AS52_RS04730	COG2252	PERMEase
AS52_RS04735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AS52_RS04740	COG1263	PTS System
AS52_RS04740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS04745	COG0366	Alpha amylase catalytic
AS52_RS04750	COG2188	Transcriptional regulator
AS52_RS04755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_RS04760	COG1984	allophanate hydrolase subunit 2
AS52_RS04765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_RS04770	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_RS04775	COG1272	protein, Hemolysin III
AS52_RS04790	COG0778	Nitroreductase
AS52_RS04795	COG0628	permease
AS52_RS04820	COG0439	Biotin carboxylase
AS52_RS04835	COG0531	amino acid
AS52_RS04840	COG0402	S-adenosylhomocysteine deaminase activity
AS52_RS04845	COG1278	Cold shock
AS52_RS04850	COG2910	NAD(P)H-binding
AS52_RS04855	COG0673	inositol 2-dehydrogenase activity
AS52_RS04860	COG0450	alkyl hydroperoxide reductase
AS52_RS04865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS04880	COG4251	negative regulation of phosphorylation
AS52_RS04880	COG3706	GGDEF domain
AS52_RS04880	COG2203	Gaf domain
AS52_RS04880	COG5001	Diguanylate cyclase
AS52_RS04885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_RS04965	COG1649	PFAM Uncharacterised BCR, COG1649
AS52_RS04970	COG1737	Transcriptional regulator
AS52_RS04990	COG1486	melibiose metabolic process
AS52_RS05000	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_RS05010	COG2971	BadF BadG BcrA BcrD
AS52_RS05015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AS52_RS05025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS52_RS05040	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS05045	COG2226	methyltransferase
AS52_RS05050	COG0583	DNA-binding transcription factor activity
AS52_RS05060	COG0667	Aldo Keto reductase
AS52_RS05075	COG0154	amidase activity
AS52_RS05090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS52_RS05160	COG2199	diguanylate cyclase activity
AS52_RS05160	COG2200	EAL domain
AS52_RS05170	COG1733	regulation of RNA biosynthetic process
AS52_RS05185	COG0385	Bile acid
AS52_RS05195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_RS05200	COG4191	Histidine kinase
AS52_RS05205	COG0784	Response regulator, receiver
AS52_RS05220	COG0791	NLP P60 protein
AS52_RS05220	COG1388	LysM domain
AS52_RS05230	COG2385	sporulation resulting in formation of a cellular spore
AS52_RS05235	COG0656	L-ascorbic acid biosynthetic process
AS52_RS05250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_RS05255	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_RS05275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS52_RS05285	COG0477	Major facilitator Superfamily
AS52_RS05290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_RS05300	COG0640	Transcriptional regulator
AS52_RS05305	COG5658	integral membrane protein
AS52_RS05330	COG3300	MHYT domain
AS52_RS05330	COG5001	Diguanylate cyclase
AS52_RS05335	COG0302	gtp cyclohydrolase
AS52_RS05350	COG5001	Diguanylate cyclase
AS52_RS05350	COG3300	MHYT domain
AS52_RS05375	COG0443	Heat shock 70 kDa protein
AS52_RS05385	COG0484	heat shock protein binding
AS52_RS05400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS52_RS05440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_RS05445	COG1396	sequence-specific DNA binding
AS52_RS05465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS52_RS05485	COG1215	transferase activity, transferring glycosyl groups
AS52_RS05500	COG0840	transmembrane signaling receptor activity
AS52_RS05510	COG2385	sporulation resulting in formation of a cellular spore
AS52_RS05510	COG2247	cell wall binding repeat
AS52_RS05540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_RS05545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS52_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS52_RS05555	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AS52_RS05565	COG0110	maltose O-acetyltransferase activity
AS52_RS05575	COG1215	transferase activity, transferring glycosyl groups
AS52_RS05600	COG0110	maltose O-acetyltransferase activity
AS52_RS05610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS52_RS05625	COG1482	cell wall glycoprotein biosynthetic process
AS52_RS05630	COG3944	biosynthesis protein
AS52_RS05635	COG0489	protein tyrosine kinase activity
AS52_RS05640	COG4464	protein tyrosine phosphatase activity
AS52_RS05645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS52_RS05650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_RS05685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AS52_RS05690	COG1682	transport, permease protein
AS52_RS05695	COG1134	teichoic acid transport
AS52_RS05705	COG1316	TRANSCRIPTIONal
AS52_RS05720	COG4464	protein tyrosine phosphatase activity
AS52_RS05730	COG0028	Belongs to the TPP enzyme family
AS52_RS05735	COG0069	glutamate synthase activity
AS52_RS05745	COG2084	Dehydrogenase
AS52_RS05780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_RS05785	COG2146	nitrite reductase [NAD(P)H] activity
AS52_RS05795	COG2116	formate transmembrane transporter activity
AS52_RS05805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_RS05810	COG4975	Glucose uptake
AS52_RS05825	COG0534	Mate efflux family protein
AS52_RS05835	COG0277	FAD linked oxidase domain protein
AS52_RS05840	COG1316	TRANSCRIPTIONal
AS52_RS05850	COG0598	Magnesium transport protein CorA
AS52_RS05855	COG1404	Belongs to the peptidase S8 family
AS52_RS05870	COG0454	-acetyltransferase
AS52_RS05870	COG0456	acetyltransferase
AS52_RS05875	COG4821	SIS domain
AS52_RS05880	COG2188	Transcriptional regulator
AS52_RS05885	COG0363	glucosamine-6-phosphate deaminase activity
AS52_RS05890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS52_RS05895	COG2190	(PTS) system
AS52_RS05895	COG1263	PTS System
AS52_RS05895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS05900	COG1811	Na channel or pump
AS52_RS05935	COG1131	(ABC) transporter
AS52_RS05940	COG1253	flavin adenine dinucleotide binding
AS52_RS05945	COG0789	Transcriptional regulator
AS52_RS05955	COG0346	lactoylglutathione lyase activity
AS52_RS05960	COG2105	PFAM AIG2 family protein
AS52_RS05960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AS52_RS05990	COG0840	transmembrane signaling receptor activity
AS52_RS05995	COG0456	acetyltransferase
AS52_RS06000	COG1473	amidohydrolase
AS52_RS06010	COG4187	Peptidase family M20/M25/M40
AS52_RS06025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_RS06025	COG0456	acetyltransferase
AS52_RS06040	COG2252	PERMEase
AS52_RS06050	COG3279	Response regulator of the LytR AlgR family
AS52_RS06055	COG4555	ABC transporter
AS52_RS06060	COG1668	transmembrane transport
AS52_RS06070	COG0789	Transcriptional regulator
AS52_RS06075	COG1846	Transcriptional regulator
AS52_RS06080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_RS06080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_RS06100	COG1785	Belongs to the alkaline phosphatase family
AS52_RS06105	COG3279	Response regulator of the LytR AlgR family
AS52_RS06110	COG0784	Response regulator, receiver
AS52_RS06110	COG2205	protein histidine kinase activity
AS52_RS06115	COG0861	Integral membrane protein TerC family
AS52_RS06120	COG1191	sigma factor activity
AS52_RS06150	COG3243	poly(R)-hydroxyalkanoic acid synthase
AS52_RS06155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS52_RS06170	COG2186	Transcriptional regulator
AS52_RS06175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS52_RS06185	COG0247	lactate metabolic process
AS52_RS06190	COG1139	Iron-sulfur cluster binding protein
AS52_RS06195	COG1556	Lactate utilization protein
AS52_RS06200	COG5002	protein histidine kinase activity
AS52_RS06205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS52_RS06210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AS52_RS06215	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AS52_RS06220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS06225	COG0436	Aminotransferase
AS52_RS06230	COG1850	ribulose-bisphosphate carboxylase activity
AS52_RS06235	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AS52_RS06240	COG0235	Class ii aldolase
AS52_RS06245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AS52_RS06255	COG1129	ABC transporter
AS52_RS06260	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS52_RS06285	COG1846	Transcriptional regulator
AS52_RS06295	COG4191	Histidine kinase
AS52_RS06305	COG0542	response to heat
AS52_RS06310	COG1757	Na H antiporter
AS52_RS06320	COG0300	oxidoreductase activity
AS52_RS06325	COG0697	spore germination
AS52_RS06345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS52_RS06350	COG0720	synthase
AS52_RS06360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AS52_RS06365	COG0702	epimerase
AS52_RS06375	COG4873	Protein conserved in bacteria
AS52_RS06395	COG3773	Cell wall hydrolase
AS52_RS06435	COG0646	methionine synthase
AS52_RS06435	COG1410	methionine synthase
AS52_RS06440	COG0646	methionine synthase
AS52_RS06440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AS52_RS06445	COG3949	Membrane
AS52_RS06455	COG0307	riboflavin synthase, alpha
AS52_RS06465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS52_RS06475	COG3711	transcriptional antiterminator
AS52_RS06480	COG1263	PTS System
AS52_RS06480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS06480	COG2190	(PTS) system
AS52_RS06495	COG1346	cytolysis
AS52_RS06505	COG0583	DNA-binding transcription factor activity
AS52_RS06515	COG0456	acetyltransferase
AS52_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS06525	COG0778	Nitroreductase
AS52_RS06530	COG0436	Aminotransferase
AS52_RS06550	COG0835	chemotaxis
AS52_RS06550	COG0784	Response regulator, receiver
AS52_RS06560	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS06580	COG1408	metallophosphoesterase
AS52_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS06590	COG2200	EAL domain
AS52_RS06605	COG4703	Protein of unknown function (DUF1797)
AS52_RS06610	COG0517	IMP dehydrogenase activity
AS52_RS06615	COG0583	DNA-binding transcription factor activity
AS52_RS06620	COG2171	N-acyltransferase activity
AS52_RS06625	COG1473	amidohydrolase
AS52_RS06635	COG0668	transmembrane transport
AS52_RS06640	COG0450	alkyl hydroperoxide reductase
AS52_RS06645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS06650	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_RS06655	COG1132	(ABC) transporter
AS52_RS06660	COG1132	(ABC) transporter
AS52_RS06665	COG0569	domain protein
AS52_RS06670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_RS06675	COG5503	Protein of unknown function (DUF1447)
AS52_RS06680	COG0561	phosphatase activity
AS52_RS06700	COG0022	dehydrogenase e1 component
AS52_RS06705	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_RS06720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS52_RS06725	COG1982	Orn Lys Arg decarboxylase major
AS52_RS06730	COG4476	Belongs to the UPF0223 family
AS52_RS06735	COG4493	Belongs to the UPF0637 family
AS52_RS06745	COG0483	inositol monophosphate 1-phosphatase activity
AS52_RS06755	COG1217	gtp-binding protein TYPA
AS52_RS06770	COG4896	Protein conserved in bacteria
AS52_RS06785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS52_RS06790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS52_RS06795	COG4838	Belongs to the UPF0358 family
AS52_RS06800	COG0772	Belongs to the SEDS family
AS52_RS06805	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS52_RS06810	COG1612	heme a metabolic process
AS52_RS06815	COG0109	protoheme IX farnesyltransferase activity
AS52_RS06840	COG3336	cytochrome c oxidase
AS52_RS06850	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AS52_RS06855	COG2340	Cysteine-rich secretory protein family
AS52_RS06865	COG2738	Putative neutral zinc metallopeptidase
AS52_RS06870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS06875	COG1694	Mazg nucleotide pyrophosphohydrolase
AS52_RS06880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AS52_RS06885	COG1803	Methylglyoxal synthase
AS52_RS06890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_RS06895	COG0438	transferase activity, transferring glycosyl groups
AS52_RS06900	COG0617	tRNA 3'-terminal CCA addition
AS52_RS06905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AS52_RS06905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AS52_RS06915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS52_RS06920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AS52_RS06925	COG1199	ATP-dependent helicase activity
AS52_RS06925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS52_RS06940	COG0436	Aminotransferase
AS52_RS06945	COG0017	Asparaginyl-tRNA synthetase
AS52_RS06950	COG3935	DnaD domain protein
AS52_RS06955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS52_RS06965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_RS06965	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS52_RS06970	COG3331	DNA recombination
AS52_RS07005	COG5337	Spore coat protein CotH
AS52_RS07020	COG0626	cystathionine gamma-synthase activity
AS52_RS07025	COG0626	cystathionine gamma-synthase activity
AS52_RS07040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_RS07065	COG3706	GGDEF domain
AS52_RS07075	COG1111	helicase
AS52_RS07075	COG1205	dead DEAH box helicase
AS52_RS07080	COG3359	exonuclease
AS52_RS07090	COG4474	Belongs to the UPF0398 family
AS52_RS07095	COG3599	regulation of cell shape
AS52_RS07120	COG2197	response regulator
AS52_RS07125	COG0366	Alpha amylase catalytic
AS52_RS07130	COG0116	Belongs to the methyltransferase superfamily
AS52_RS07145	COG1175	transmembrane transport
AS52_RS07155	COG3842	ATPase activity
AS52_RS07165	COG1199	ATP-dependent helicase activity
AS52_RS07170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS52_RS07175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_RS07180	COG2233	PERMEase
AS52_RS07185	COG0583	DNA-binding transcription factor activity
AS52_RS07190	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS07200	COG3424	synthase
AS52_RS07205	COG1755	Isoprenylcysteine carboxyl methyltransferase
AS52_RS07210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS52_RS07215	COG3541	Predicted nucleotidyltransferase
AS52_RS07240	COG0328	RNA-DNA hybrid ribonuclease activity
AS52_RS07245	COG0328	RNA-DNA hybrid ribonuclease activity
AS52_RS07270	COG2814	Major facilitator Superfamily
AS52_RS07280	COG2233	PERMEase
AS52_RS07285	COG2362	D-Aminopeptidase
AS52_RS07290	COG0601	transmembrane transport
AS52_RS07295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_RS07300	COG0444	Belongs to the ABC transporter superfamily
AS52_RS07305	COG4166	transmembrane transport
AS52_RS07310	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS52_RS07315	COG0791	NLP P60 protein
AS52_RS07320	COG4608	Belongs to the ABC transporter superfamily
AS52_RS07340	COG5001	Diguanylate cyclase
AS52_RS07340	COG3300	MHYT domain
AS52_RS07345	COG3689	TIGRFAM TIGR03943 family protein
AS52_RS07350	COG0701	Predicted permease
AS52_RS07355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS52_RS07360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS07365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS07370	COG1120	ATPase activity
AS52_RS07400	COG2197	response regulator
AS52_RS07405	COG4585	Histidine kinase
AS52_RS07410	COG3239	Fatty acid desaturase
AS52_RS07425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS07440	COG1388	LysM domain
AS52_RS07440	COG0791	NLP P60 protein
AS52_RS07445	COG1819	glycosyl
AS52_RS07450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_RS07460	COG2814	Major facilitator Superfamily
AS52_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS07480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS52_RS07485	COG1404	Belongs to the peptidase S8 family
AS52_RS07495	COG1846	Transcriptional regulator
AS52_RS07500	COG1566	PFAM secretion protein HlyD family protein
AS52_RS07505	COG2814	Major facilitator Superfamily
AS52_RS07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS07525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS07530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_RS07535	COG1120	ATPase activity
AS52_RS07540	COG0492	ferredoxin-NADP+ reductase activity
AS52_RS07550	COG2814	Major facilitator Superfamily
AS52_RS07570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_RS07575	COG1733	regulation of RNA biosynthetic process
AS52_RS07580	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AS52_RS07590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_RS07600	COG3448	diguanylate cyclase activity
AS52_RS07600	COG4175	Glycine betaine
AS52_RS07615	COG0469	pyruvate kinase activity
AS52_RS07620	COG0784	Response regulator, receiver
AS52_RS07620	COG2205	protein histidine kinase activity
AS52_RS07625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS52_RS07630	COG2208	phosphoserine phosphatase activity
AS52_RS07640	COG0531	amino acid
AS52_RS07650	COG1011	Hydrolase
AS52_RS07655	COG0405	Gamma-glutamyltransferase
AS52_RS07660	COG1621	beta-fructofuranosidase activity
AS52_RS07665	COG1621	beta-fructofuranosidase activity
AS52_RS07670	COG2193	ferroxidase activity
AS52_RS07675	COG0477	Major facilitator Superfamily
AS52_RS07680	COG0156	8-amino-7-oxononanoate synthase activity
AS52_RS07685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS52_RS07695	COG2814	Major facilitator Superfamily
AS52_RS07710	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS07720	COG1280	lysine exporter protein (LysE YggA)
AS52_RS07725	COG1113	amino acid transport
AS52_RS07730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_RS07750	COG1113	amino acid transport
AS52_RS07765	COG1609	Transcriptional regulator
AS52_RS07780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS52_RS07785	COG1621	beta-fructofuranosidase activity
AS52_RS07790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AS52_RS07790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AS52_RS07795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS07800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS07805	COG3715	PTS system
AS52_RS07810	COG3716	PTS system mannose fructose sorbose family IID component
AS52_RS07815	COG1621	beta-fructofuranosidase activity
AS52_RS07835	COG1464	Belongs to the NlpA lipoprotein family
AS52_RS07840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS52_RS07845	COG2011	ABC-type metal ion transport system permease component
AS52_RS07850	COG1464	Belongs to the NlpA lipoprotein family
AS52_RS07855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS07860	COG0024	Methionine aminopeptidase
AS52_RS07870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS52_RS07880	COG0656	L-ascorbic acid biosynthetic process
AS52_RS07885	COG2986	histidine ammonia-lyase
AS52_RS07895	COG1228	amidohydrolase
AS52_RS07900	COG0010	Belongs to the arginase family
AS52_RS07905	COG1846	Transcriptional regulator
AS52_RS07915	COG1288	antiporter activity
AS52_RS07920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS52_RS07945	COG4221	oxidoreductase activity
AS52_RS07950	COG0789	Transcriptional regulator
AS52_RS07960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS07975	COG2364	Membrane
AS52_RS07980	COG1846	Transcriptional regulator
AS52_RS07985	COG0456	acetyltransferase
AS52_RS07990	COG0640	Transcriptional regulator
AS52_RS08050	COG2190	(PTS) system
AS52_RS08050	COG1263	PTS System
AS52_RS08050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS08055	COG2723	6-phospho-beta-galactosidase activity
AS52_RS08065	COG0574	Belongs to the PEP-utilizing enzyme family
AS52_RS08065	COG3848	Pyruvate phosphate dikinase
AS52_RS08070	COG1309	transcriptional regulator
AS52_RS08075	COG2814	Major facilitator Superfamily
AS52_RS08090	COG0494	nUDIX hydrolase
AS52_RS08105	COG1388	LysM domain
AS52_RS08105	COG0791	NLP P60 protein
AS52_RS08125	COG2318	DinB family
AS52_RS08150	COG0583	DNA-binding transcription factor activity
AS52_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS08200	COG0586	Pfam SNARE associated Golgi protein
AS52_RS08225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_RS08235	COG0697	spore germination
AS52_RS08270	COG0387	Pfam Sodium calcium exchanger
AS52_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS08300	COG1309	transcriptional regulator
AS52_RS08305	COG0861	Integral membrane protein TerC family
AS52_RS08310	COG2188	Transcriptional regulator
AS52_RS08315	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_RS08325	COG2723	6-phospho-beta-galactosidase activity
AS52_RS08335	COG1940	carbohydrate kinase activity
AS52_RS08350	COG1522	sequence-specific DNA binding
AS52_RS08355	COG3813	Protein conserved in bacteria
AS52_RS08395	COG2076	Multidrug Resistance protein
AS52_RS08440	COG1278	Cold shock
AS52_RS08450	COG0028	Belongs to the TPP enzyme family
AS52_RS08485	COG2172	sigma factor antagonist activity
AS52_RS08490	COG1388	LysM domain
AS52_RS08490	COG3858	chitin binding
AS52_RS08495	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS08500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS52_RS08530	COG2226	methyltransferase
AS52_RS08540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS08555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_RS08560	COG0640	Transcriptional regulator
AS52_RS08570	COG0640	Transcriptional regulator
AS52_RS08575	COG0346	lactoylglutathione lyase activity
AS52_RS08580	COG5553	Cysteine dioxygenase type I
AS52_RS08585	COG0697	spore germination
AS52_RS08590	COG1733	regulation of RNA biosynthetic process
AS52_RS08595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS08605	COG2207	Transcriptional regulator
AS52_RS08615	COG2376	Dihydroxyacetone kinase
AS52_RS08645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_RS08725	COG1266	CAAX protease self-immunity
AS52_RS08735	COG2814	Major facilitator Superfamily
AS52_RS08740	COG0789	Transcriptional regulator
AS52_RS08745	COG0667	Aldo Keto reductase
AS52_RS08910	COG2801	Transposase and inactivated derivatives
AS52_RS08930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS52_RS08940	COG4282	regulation of fungal-type cell wall biogenesis
AS52_RS08970	COG3848	Pyruvate phosphate dikinase
AS52_RS08970	COG0574	Belongs to the PEP-utilizing enzyme family
AS52_RS08975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AS52_RS08985	COG0601	transmembrane transport
AS52_RS08990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_RS08995	COG0444	Belongs to the ABC transporter superfamily
AS52_RS09000	COG4608	Belongs to the ABC transporter superfamily
AS52_RS09005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS52_RS09020	COG3852	Histidine kinase
AS52_RS09025	COG4191	Histidine kinase
AS52_RS09030	COG2204	response regulator
AS52_RS09040	COG0477	Major facilitator Superfamily
AS52_RS09045	COG0300	oxidoreductase activity
AS52_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS52_RS09075	COG1454	alcohol dehydrogenase
AS52_RS09085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AS52_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS09135	COG0517	IMP dehydrogenase activity
AS52_RS09150	COG1309	transcriptional regulator
AS52_RS09165	COG1070	Carbohydrate kinase
AS52_RS09170	COG2814	Major facilitator Superfamily
AS52_RS09170	COG0477	Major facilitator Superfamily
AS52_RS09180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS52_RS09185	COG1845	cytochrome c oxidase, subunit III
AS52_RS09190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS52_RS09195	COG0589	response to stress
AS52_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS09205	COG1612	heme a metabolic process
AS52_RS09210	COG2072	flavoprotein involved in K transport
AS52_RS09220	COG2252	PERMEase
AS52_RS09230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS52_RS09235	COG0022	dehydrogenase e1 component
AS52_RS09240	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_RS09245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS52_RS09250	COG3284	Transcriptional regulator
AS52_RS09260	COG1846	Transcriptional regulator
AS52_RS09295	COG0628	permease
AS52_RS09300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_RS09305	COG1904	glucuronate isomerase
AS52_RS09310	COG2211	Major facilitator Superfamily
AS52_RS09315	COG1609	Transcriptional regulator
AS52_RS09320	COG0246	Mannitol dehydrogenase
AS52_RS09325	COG2721	sulfolactate sulfo-lyase activity
AS52_RS09340	COG2211	Major facilitator Superfamily
AS52_RS09360	COG0589	response to stress
AS52_RS09365	COG5002	protein histidine kinase activity
AS52_RS09375	COG1937	Protein conserved in bacteria
AS52_RS09380	COG2608	mercury ion transmembrane transporter activity
AS52_RS09385	COG2217	Heavy metal translocating P-type atpase
AS52_RS09395	COG1388	LysM domain
AS52_RS09400	COG2271	Major facilitator Superfamily
AS52_RS09440	COG0640	Transcriptional regulator
AS52_RS09445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_RS09450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS52_RS09455	COG2050	protein possibly involved in aromatic compounds catabolism
AS52_RS09460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AS52_RS09465	COG2323	membrane
AS52_RS09480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_RS09485	COG0473	3-isopropylmalate dehydrogenase activity
AS52_RS09490	COG2814	Major facilitator Superfamily
AS52_RS09495	COG1733	regulation of RNA biosynthetic process
AS52_RS09500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS52_RS09500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS52_RS09505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS52_RS09505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS52_RS09520	COG2226	methyltransferase
AS52_RS09525	COG5566	PFAM Mor transcription activator
AS52_RS09540	COG0561	phosphatase activity
AS52_RS09545	COG1876	peptidase activity
AS52_RS09585	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AS52_RS09600	COG0386	Belongs to the glutathione peroxidase family
AS52_RS09605	COG1418	mRNA catabolic process
AS52_RS09610	COG0488	(ABC) transporter
AS52_RS09615	COG1413	lyase activity
AS52_RS09620	COG0726	polysaccharide deacetylase
AS52_RS09630	COG2136	Putative SAM-dependent methyltransferase
AS52_RS09630	COG2521	methyltransferase
AS52_RS09640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS09645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_RS09655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AS52_RS09665	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AS52_RS09670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AS52_RS09675	COG0406	alpha-ribazole phosphatase activity
AS52_RS09685	COG2096	Adenosyltransferase
AS52_RS09690	COG2962	Rard protein
AS52_RS09705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS52_RS09710	COG0322	excinuclease ABC activity
AS52_RS09720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_RS09725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_RS09730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_RS09740	COG3011	Protein conserved in bacteria
AS52_RS09745	COG1595	DNA-templated transcription, initiation
AS52_RS09765	COG2002	toxin-antitoxin pair type II binding
AS52_RS09770	COG0534	Mate efflux family protein
AS52_RS09800	COG1368	sulfuric ester hydrolase activity
AS52_RS09810	COG3853	Toxic anion resistance protein (TelA)
AS52_RS09835	COG2234	aminopeptidase activity
AS52_RS09840	COG5002	protein histidine kinase activity
AS52_RS09850	COG1823	symporter activity
AS52_RS09855	COG1523	belongs to the glycosyl hydrolase 13 family
AS52_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS09865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS52_RS09865	COG2124	cytochrome p450
AS52_RS09870	COG2112	serine threonine protein kinase
AS52_RS09880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS52_RS09885	COG1360	Flagellar Motor Protein
AS52_RS09900	COG3361	conserved protein (COG2071)
AS52_RS09905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_RS09910	COG1757	Na H antiporter
AS52_RS09920	COG0833	amino acid
AS52_RS09925	COG3594	Acyltransferase
AS52_RS09930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_RS09935	COG0745	RESPONSE REGULATOR receiver
AS52_RS09940	COG5002	protein histidine kinase activity
AS52_RS09945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS52_RS09950	COG3104	oligopeptide transport
AS52_RS09960	COG0281	malic enzyme
AS52_RS09965	COG3493	citrate carrier protein
AS52_RS09970	COG0561	phosphatase activity
AS52_RS09975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS09985	COG0456	acetyltransferase
AS52_RS09990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AS52_RS09995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_RS10000	COG0765	amino acid transport
AS52_RS10005	COG0765	amino acid transport
AS52_RS10010	COG1126	abc transporter atp-binding protein
AS52_RS10015	COG0196	riboflavin kinase activity
AS52_RS10020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS10030	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS10050	COG2188	Transcriptional regulator
AS52_RS10055	COG1070	Carbohydrate kinase
AS52_RS10060	COG2140	Oxalate decarboxylase
AS52_RS10065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_RS10085	COG0363	glucosamine-6-phosphate deaminase activity
AS52_RS10090	COG0738	Major facilitator superfamily
AS52_RS10115	COG1611	Belongs to the LOG family
AS52_RS10120	COG0281	malic enzyme
AS52_RS10125	COG3402	PFAM membrane-flanked domain
AS52_RS10130	COG3428	Bacterial PH domain
AS52_RS10145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_RS10150	COG0109	protoheme IX farnesyltransferase activity
AS52_RS10155	COG4195	phage-related replication protein
AS52_RS10165	COG0789	Transcriptional regulator
AS52_RS10195	COG0583	DNA-binding transcription factor activity
AS52_RS10200	COG0067	glutamate synthase
AS52_RS10200	COG0070	glutamate synthase
AS52_RS10200	COG0069	glutamate synthase activity
AS52_RS10205	COG0493	'glutamate synthase
AS52_RS10225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AS52_RS10240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS10250	COG1846	Transcriptional regulator
AS52_RS10255	COG1380	Effector of murein hydrolase LrgA
AS52_RS10260	COG1346	cytolysis
AS52_RS10265	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS10280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AS52_RS10285	COG0463	Glycosyl transferase, family 2
AS52_RS10290	COG2246	polysaccharide biosynthetic process
AS52_RS10295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_RS10300	COG0745	RESPONSE REGULATOR receiver
AS52_RS10315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS52_RS10325	COG4208	sulfate ABC transporter
AS52_RS10340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS10350	COG1349	DNA-binding transcription factor activity
AS52_RS10355	COG1105	Belongs to the carbohydrate kinase PfkB family
AS52_RS10360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS52_RS10360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS52_RS10360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS10365	COG0527	aspartate kinase activity
AS52_RS10375	COG2032	superoxide dismutase activity
AS52_RS10380	COG1233	COG1233 Phytoene dehydrogenase and related
AS52_RS10390	COG0300	oxidoreductase activity
AS52_RS10395	COG0640	Transcriptional regulator
AS52_RS10400	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS10405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS52_RS10420	COG0733	neurotransmitter:sodium symporter activity
AS52_RS10425	COG3773	Cell wall hydrolase
AS52_RS10445	COG0673	inositol 2-dehydrogenase activity
AS52_RS10450	COG1082	Xylose isomerase domain protein TIM barrel
AS52_RS10455	COG2094	Belongs to the DNA glycosylase MPG family
AS52_RS10460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS52_RS10470	COG0454	-acetyltransferase
AS52_RS10480	COG2814	Major facilitator Superfamily
AS52_RS10495	COG3871	stress protein (general stress protein 26)
AS52_RS10515	COG1595	DNA-templated transcription, initiation
AS52_RS10520	COG4873	Protein conserved in bacteria
AS52_RS10525	COG0714	Associated with various cellular activities
AS52_RS10530	COG4548	von Willebrand factor, type A
AS52_RS10535	COG0697	spore germination
AS52_RS10545	COG2207	Transcriptional regulator
AS52_RS10550	COG1994	Peptidase M50
AS52_RS10560	COG1119	ATPase activity
AS52_RS10575	COG1657	PFAM Prenyltransferase squalene oxidase
AS52_RS10585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS52_RS10585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS52_RS10605	COG1378	Sugar-specific transcriptional regulator TrmB
AS52_RS10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_RS10640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS10645	COG1279	arginine transmembrane transporter activity
AS52_RS10710	COG1279	arginine transmembrane transporter activity
AS52_RS10740	COG3541	Predicted nucleotidyltransferase
AS52_RS10755	COG1396	sequence-specific DNA binding
AS52_RS10770	COG0494	nUDIX hydrolase
AS52_RS10775	COG1335	isochorismatase
AS52_RS10780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS52_RS10785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS52_RS10790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AS52_RS10795	COG1098	S1 RNA binding domain
AS52_RS10800	COG1404	Belongs to the peptidase S8 family
AS52_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS10810	COG1254	Belongs to the acylphosphatase family
AS52_RS10815	COG2223	nitrite transmembrane transporter activity
AS52_RS10820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS10825	COG0463	Glycosyl transferase, family 2
AS52_RS10835	COG0662	Cupin 2, conserved barrel domain protein
AS52_RS10835	COG2207	Transcriptional regulator
AS52_RS10840	COG0697	spore germination
AS52_RS10845	COG0488	(ABC) transporter
AS52_RS10850	COG0697	spore germination
AS52_RS10855	COG0531	amino acid
AS52_RS10870	COG1131	(ABC) transporter
AS52_RS10875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_RS10880	COG1757	Na H antiporter
AS52_RS10885	COG1609	Transcriptional regulator
AS52_RS10895	COG1533	DNA photolyase activity
AS52_RS10915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS52_RS10915	COG0551	DNA topoisomerase type I activity
AS52_RS10925	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS52_RS10955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS10975	COG1757	Na H antiporter
AS52_RS10980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_RS10990	COG0697	spore germination
AS52_RS11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS11005	COG5002	protein histidine kinase activity
AS52_RS11010	COG2204	response regulator
AS52_RS11020	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS11030	COG1027	Aspartate ammonia-lyase
AS52_RS11035	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS11045	COG1454	alcohol dehydrogenase
AS52_RS11050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS52_RS11055	COG2720	vancomycin resistance protein
AS52_RS11095	COG0514	ATP-dependent DNA helicase (RecQ)
AS52_RS11110	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS11125	COG1575	Belongs to the MenA family. Type 1 subfamily
AS52_RS11145	COG2814	Major facilitator Superfamily
AS52_RS11150	COG0583	DNA-binding transcription factor activity
AS52_RS11155	COG1725	Transcriptional regulator
AS52_RS11160	COG1131	(ABC) transporter
AS52_RS11170	COG1595	DNA-templated transcription, initiation
AS52_RS11185	COG1764	response to oxidative stress
AS52_RS11190	COG1846	Transcriptional regulator
AS52_RS11205	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
AS52_RS11215	COG1388	LysM domain
AS52_RS11215	COG3584	3D domain protein
AS52_RS11235	COG5002	protein histidine kinase activity
AS52_RS11240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_RS11245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS52_RS11250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AS52_RS11265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS52_RS11280	COG2409	Drug exporters of the RND superfamily
AS52_RS11285	COG1834	amidinotransferase
AS52_RS11295	COG1295	ribonuclease BN
AS52_RS11350	COG0346	lactoylglutathione lyase activity
AS52_RS11360	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS11370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_RS11375	COG2176	DNA-directed DNA polymerase activity
AS52_RS11390	COG0114	fumarate hydratase activity
AS52_RS11400	COG3409	Peptidoglycan-binding domain 1 protein
AS52_RS11400	COG3757	hydrolase, family 25
AS52_RS11410	COG5002	protein histidine kinase activity
AS52_RS11450	COG0778	Nitroreductase
AS52_RS11460	COG0300	oxidoreductase activity
AS52_RS11470	COG2610	gluconate transmembrane transporter activity
AS52_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS11480	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS52_RS11495	COG4122	O-methyltransferase activity
AS52_RS11500	COG0583	DNA-binding transcription factor activity
AS52_RS11510	COG1301	dicarboxylic acid transport
AS52_RS11515	COG0019	diaminopimelate decarboxylase activity
AS52_RS11525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_RS11535	COG4191	Histidine kinase
AS52_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS11555	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS11565	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_RS11570	COG1024	Enoyl-CoA hydratase
AS52_RS11585	COG2045	Belongs to the ComB family
AS52_RS11590	COG1960	acyl-CoA dehydrogenase activity
AS52_RS11595	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS11600	COG1024	Enoyl-CoA hydratase
AS52_RS11605	COG0604	alcohol dehydrogenase
AS52_RS11605	COG3321	synthase
AS52_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS11615	COG1141	Ferredoxin
AS52_RS11625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_RS11630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS52_RS11635	COG0183	Belongs to the thiolase family
AS52_RS11640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_RS11645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS52_RS11665	COG1509	lysine 2,3-aminomutase activity
AS52_RS11675	COG0833	amino acid
AS52_RS11680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS11690	COG0456	acetyltransferase
AS52_RS11695	COG1979	alcohol dehydrogenase
AS52_RS11700	COG0738	Major facilitator superfamily
AS52_RS11710	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_RS11715	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS52_RS11720	COG3773	Cell wall hydrolase
AS52_RS11730	COG3119	arylsulfatase activity
AS52_RS11735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS52_RS11745	COG0531	amino acid
AS52_RS11750	COG2814	Major facilitator Superfamily
AS52_RS11755	COG1846	Transcriptional regulator
AS52_RS11760	COG1033	growth of symbiont in host cell
AS52_RS11760	COG2409	Drug exporters of the RND superfamily
AS52_RS11765	COG2202	Pas domain
AS52_RS11765	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS11770	COG3832	glyoxalase III activity
AS52_RS11775	COG0640	Transcriptional regulator
AS52_RS11790	COG2267	carboxylic ester hydrolase activity
AS52_RS11800	COG3386	PFAM SMP-30 Gluconolaconase
AS52_RS11810	COG2368	4-hydroxyphenylacetate
AS52_RS11815	COG3739	integral membrane protein
AS52_RS11825	COG0326	Molecular chaperone. Has ATPase activity
AS52_RS11830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_RS11850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS52_RS11855	COG3757	hydrolase, family 25
AS52_RS11855	COG3409	Peptidoglycan-binding domain 1 protein
AS52_RS11865	COG0697	spore germination
AS52_RS11870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS11885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS11890	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AS52_RS11895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS52_RS11940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_RS11955	COG0494	nUDIX hydrolase
AS52_RS11960	COG0702	epimerase
AS52_RS11965	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS11970	COG1846	Transcriptional regulator
AS52_RS11975	COG2720	vancomycin resistance protein
AS52_RS11980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS52_RS12025	COG0076	glutamate decarboxylase activity
AS52_RS12050	COG2116	formate transmembrane transporter activity
AS52_RS12055	COG5609	conserved protein (DUF2294)
AS52_RS12070	COG2271	Major facilitator Superfamily
AS52_RS12075	COG0277	FAD linked oxidase domain protein
AS52_RS12080	COG0840	transmembrane signaling receptor activity
AS52_RS12100	COG1408	metallophosphoesterase
AS52_RS12105	COG3663	DNA glycosylase
AS52_RS12110	COG3883	PFAM NLP P60 protein
AS52_RS12110	COG0791	NLP P60 protein
AS52_RS12115	COG1587	Uroporphyrinogen-III synthase
AS52_RS12120	COG1414	Transcriptional regulator
AS52_RS12125	COG0439	Biotin carboxylase
AS52_RS12130	COG0511	ligase activity, forming carbon-carbon bonds
AS52_RS12135	COG1984	allophanate hydrolase subunit 2
AS52_RS12140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_RS12145	COG4336	lyase activity
AS52_RS12150	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_RS12155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_RS12255	COG0772	Belongs to the SEDS family
AS52_RS12270	COG1595	DNA-templated transcription, initiation
AS52_RS12290	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS12295	COG1268	BioY protein
AS52_RS12300	COG0183	Belongs to the thiolase family
AS52_RS12320	COG0431	NADPH-dependent FMN reductase
AS52_RS12325	COG2197	response regulator
AS52_RS12330	COG4585	Histidine kinase
AS52_RS12330	COG2203	Gaf domain
AS52_RS12350	COG0697	spore germination
AS52_RS12360	COG2153	protein acetylation
AS52_RS12365	COG0129	dihydroxy-acid dehydratase activity
AS52_RS12370	COG2267	carboxylic ester hydrolase activity
AS52_RS12375	COG1227	inorganic diphosphatase activity
AS52_RS12395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS52_RS12405	COG0204	Acyl-transferase
AS52_RS12410	COG2233	PERMEase
AS52_RS12425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS12440	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_RS12455	COG1011	Hydrolase
AS52_RS12460	COG1846	Transcriptional regulator
AS52_RS12470	COG4974	Belongs to the 'phage' integrase family
AS52_RS12485	COG0531	amino acid
AS52_RS12490	COG4302	ethanolamine ammonia-lyase activity
AS52_RS12495	COG4303	Ethanolamine ammonia lyase large subunit
AS52_RS12500	COG4819	ethanolamine utilization protein
AS52_RS12510	COG0833	amino acid
AS52_RS12520	COG1247	-acetyltransferase
AS52_RS12525	COG1335	isochorismatase
AS52_RS12535	COG3403	YqcI/YcgG family
AS52_RS12540	COG1280	lysine exporter protein (LysE YggA)
AS52_RS12545	COG2267	carboxylic ester hydrolase activity
AS52_RS12550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS52_RS12555	COG0187	DNA topoisomerase II activity
AS52_RS12560	COG1832	CoA-binding protein
AS52_RS12565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS52_RS12570	COG4841	protein insertion into membrane
AS52_RS12575	COG0824	Thioesterase
AS52_RS12600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS12605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS52_RS12625	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AS52_RS12695	COG1183	phosphatidylcholine synthase activity
AS52_RS12710	COG2814	Major facilitator Superfamily
AS52_RS12715	COG1683	Conserved Protein
AS52_RS12720	COG1302	Protein conserved in bacteria
AS52_RS12735	COG1295	ribonuclease BN
AS52_RS12745	COG1115	amino acid carrier protein
AS52_RS12750	COG2814	Major facilitator Superfamily
AS52_RS12760	COG2814	Major facilitator Superfamily
AS52_RS12765	COG0789	Transcriptional regulator
AS52_RS12775	COG0288	reversible hydration of carbon dioxide
AS52_RS12780	COG0659	secondary active sulfate transmembrane transporter activity
AS52_RS12785	COG0745	RESPONSE REGULATOR receiver
AS52_RS12790	COG5002	protein histidine kinase activity
AS52_RS12800	COG4282	regulation of fungal-type cell wall biogenesis
AS52_RS12805	COG0531	amino acid
AS52_RS12815	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS12820	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AS52_RS12890	COG1363	Peptidase, m42
AS52_RS12900	COG1114	Component of the transport system for branched-chain amino acids
AS52_RS12915	COG0004	ammonium transporteR
AS52_RS12930	COG1252	NADH dehydrogenase
AS52_RS12935	COG0679	Auxin Efflux Carrier
AS52_RS12940	COG0281	malic enzyme
AS52_RS12945	COG1473	amidohydrolase
AS52_RS12950	COG2271	Major facilitator Superfamily
AS52_RS12970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AS52_RS12975	COG0163	prenyltransferase activity
AS52_RS12980	COG0583	DNA-binding transcription factor activity
AS52_RS12985	COG0679	Auxin Efflux Carrier
AS52_RS13005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS13010	COG0247	lactate metabolic process
AS52_RS13015	COG0277	FAD linked oxidase domain protein
AS52_RS13020	COG3835	regulator
AS52_RS13025	COG0693	protein deglycase activity
AS52_RS13035	COG2610	gluconate transmembrane transporter activity
AS52_RS13055	COG1131	(ABC) transporter
AS52_RS13065	COG2197	response regulator
AS52_RS13100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS13110	COG0586	Pfam SNARE associated Golgi protein
AS52_RS13115	COG1515	deoxyribonuclease V activity
AS52_RS13120	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_RS13125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS13125	COG3153	acetyltransferase
AS52_RS13135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS13140	COG0531	amino acid
AS52_RS13320	COG5444	nuclease activity
AS52_RS13335	COG0534	Mate efflux family protein
AS52_RS13340	COG1566	PFAM secretion protein HlyD family protein
AS52_RS13350	COG1846	Transcriptional regulator
AS52_RS13355	COG0708	Exodeoxyribonuclease III
AS52_RS13365	COG0673	inositol 2-dehydrogenase activity
AS52_RS13370	COG1349	DNA-binding transcription factor activity
AS52_RS13375	COG3853	Toxic anion resistance protein (TelA)
AS52_RS13385	COG2310	stress, protein
AS52_RS13390	COG2310	stress, protein
AS52_RS13395	COG2310	stress, protein
AS52_RS13400	COG0737	Belongs to the 5'-nucleotidase family
AS52_RS13415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_RS13420	COG1131	(ABC) transporter
AS52_RS13430	COG2084	Dehydrogenase
AS52_RS13435	COG1278	Cold shock
AS52_RS13440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS13445	COG0028	Belongs to the TPP enzyme family
AS52_RS13450	COG1278	Cold shock
AS52_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS13490	COG0427	acetyl-CoA hydrolase
AS52_RS13495	COG3279	Response regulator of the LytR AlgR family
AS52_RS13500	COG2323	membrane
AS52_RS13505	COG2814	Major facilitator Superfamily
AS52_RS13510	COG1388	LysM domain
AS52_RS13510	COG3584	3D domain protein
AS52_RS13515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS52_RS13540	COG3340	Belongs to the peptidase S51 family
AS52_RS13555	COG0277	FAD linked oxidase domain protein
AS52_RS13615	COG1486	melibiose metabolic process
AS52_RS13620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_RS13625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_RS13640	COG0579	oxidoreductase
AS52_RS13845	COG5444	nuclease activity
AS52_RS13865	COG0488	(ABC) transporter
AS52_RS13870	COG1486	melibiose metabolic process
AS52_RS13875	COG0395	ABC-type sugar transport system, permease component
AS52_RS13880	COG1175	transmembrane transport
AS52_RS13885	COG1653	transport
AS52_RS13890	COG1609	Transcriptional regulator
AS52_RS13900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_RS13920	COG0596	Alpha beta hydrolase
AS52_RS13925	COG1929	Belongs to the glycerate kinase type-1 family
AS52_RS13930	COG2610	gluconate transmembrane transporter activity
AS52_RS13935	COG3835	regulator
AS52_RS13940	COG1454	alcohol dehydrogenase
AS52_RS13945	COG3152	Membrane
AS52_RS13960	COG0492	ferredoxin-NADP+ reductase activity
AS52_RS13970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_RS13975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS13980	COG3152	Membrane
AS52_RS13985	COG3152	Membrane
AS52_RS14005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_RS14015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS52_RS14030	COG2390	Transcriptional regulator
AS52_RS14055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS52_RS14065	COG1695	Transcriptional regulator
AS52_RS14070	COG0501	Belongs to the peptidase M48B family
AS52_RS14075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS14080	COG1742	UPF0060 membrane protein
AS52_RS14090	COG2182	Extracellular solute-binding protein
AS52_RS14110	COG2031	fatty acid transporter
AS52_RS14140	COG2391	methyltransferase activity
AS52_RS14155	COG1979	alcohol dehydrogenase
AS52_RS14160	COG0583	DNA-binding transcription factor activity
AS52_RS14175	COG0456	acetyltransferase
AS52_RS14210	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS14215	COG1063	alcohol dehydrogenase
AS52_RS14245	COG0025	NhaP-type Na H and K H
AS52_RS14250	COG1253	flavin adenine dinucleotide binding
AS52_RS14270	COG4608	Belongs to the ABC transporter superfamily
AS52_RS14280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_RS14285	COG0601	transmembrane transport
AS52_RS14290	COG0747	negative chemotaxis
AS52_RS14300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS14315	COG0583	DNA-binding transcription factor activity
AS52_RS14320	COG0697	spore germination
AS52_RS14335	COG0579	oxidoreductase
AS52_RS14340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AS52_RS14345	COG0561	phosphatase activity
AS52_RS14360	COG0668	transmembrane transport
AS52_RS14390	COG2309	aminopeptidase activity
AS52_RS14395	COG1414	Transcriptional regulator
AS52_RS14400	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS52_RS14405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS52_RS14410	COG0277	FAD linked oxidase domain protein
AS52_RS14415	COG0247	lactate metabolic process
AS52_RS14420	COG0277	FAD linked oxidase domain protein
AS52_RS14425	COG1620	l-lactate permease
AS52_RS14435	COG2271	Major facilitator Superfamily
AS52_RS14440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS14450	COG1802	Transcriptional regulator
AS52_RS14465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_RS14470	COG1131	(ABC) transporter
AS52_RS14490	COG1595	DNA-templated transcription, initiation
AS52_RS14515	COG4682	membrane
AS52_RS14530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS14535	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS14540	COG0598	Magnesium transport protein CorA
AS52_RS14545	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS52_RS14555	COG2323	membrane
AS52_RS14560	COG1876	peptidase activity
AS52_RS14570	COG5002	protein histidine kinase activity
AS52_RS14575	COG0745	RESPONSE REGULATOR receiver
AS52_RS14595	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_RS14610	COG2814	Major facilitator Superfamily
AS52_RS14615	COG1764	response to oxidative stress
AS52_RS14625	COG2311	Membrane
AS52_RS14700	COG0347	Belongs to the P(II) protein family
AS52_RS14705	COG0004	ammonium transporteR
AS52_RS14710	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AS52_RS14725	COG0596	Alpha beta hydrolase
AS52_RS14735	COG0456	acetyltransferase
AS52_RS14735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_RS14740	COG1960	acyl-CoA dehydrogenase activity
AS52_RS14780	COG4604	ABC transporter, ATP-binding protein
AS52_RS14785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS14790	COG1492	cobalamin metabolic process
AS52_RS14800	COG0531	amino acid
AS52_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS14815	COG2404	hydrolase activity, acting on ester bonds
AS52_RS14820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS52_RS14830	COG1609	Transcriptional regulator
AS52_RS14840	COG2271	Major facilitator Superfamily
AS52_RS14845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_RS14860	COG1233	COG1233 Phytoene dehydrogenase and related
AS52_RS14865	COG1215	transferase activity, transferring glycosyl groups
AS52_RS14920	COG0831	urea catabolic process
AS52_RS14925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS52_RS14930	COG1388	LysM domain
AS52_RS14930	COG0791	NLP P60 protein
AS52_RS14935	COG1388	LysM domain
AS52_RS14935	COG3584	3D domain protein
AS52_RS14940	COG1388	LysM domain
AS52_RS14940	COG3942	CHAP domain
AS52_RS14945	COG0778	Nitroreductase
AS52_RS14950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_RS14955	COG0586	Pfam SNARE associated Golgi protein
AS52_RS14965	COG0400	carboxylic ester hydrolase activity
AS52_RS14970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_RS14975	COG2244	polysaccharide biosynthetic process
AS52_RS14980	COG0697	spore germination
AS52_RS14985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS15005	COG1132	(ABC) transporter
AS52_RS15030	COG4195	phage-related replication protein
AS52_RS15040	COG0783	Belongs to the Dps family
AS52_RS15050	COG5577	PFAM Coat F domain
AS52_RS15055	COG1253	flavin adenine dinucleotide binding
AS52_RS15070	COG0516	GMP reductase activity
AS52_RS15070	COG0517	IMP dehydrogenase activity
AS52_RS15080	COG0723	plastoquinol--plastocyanin reductase activity
AS52_RS15080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_RS15095	COG0287	Prephenate dehydrogenase
AS52_RS15105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS52_RS15105	COG1605	Chorismate mutase
AS52_RS15115	COG2059	Chromate
AS52_RS15120	COG2059	Chromate
AS52_RS15130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS52_RS15135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_RS15140	COG2508	Transcriptional regulator
AS52_RS15145	COG0011	TIGRFAM Protein of
AS52_RS15150	COG1388	LysM domain
AS52_RS15150	COG0791	NLP P60 protein
AS52_RS15155	COG0753	catalase activity
AS52_RS15165	COG0733	neurotransmitter:sodium symporter activity
AS52_RS15205	COG0730	response to heat
AS52_RS15210	COG1902	pentaerythritol trinitrate reductase activity
AS52_RS15225	COG2205	protein histidine kinase activity
AS52_RS15235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AS52_RS15255	COG0640	Transcriptional regulator
AS52_RS15265	COG0778	Nitroreductase
AS52_RS15280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_RS15285	COG4991	sh3 domain protein
AS52_RS15285	COG3103	Sh3 type 3 domain protein
AS52_RS15285	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS15290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS52_RS15295	COG2002	toxin-antitoxin pair type II binding
AS52_RS15300	COG2318	DinB family
AS52_RS15305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_RS15315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AS52_RS15320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS15335	COG2211	Major facilitator Superfamily
AS52_RS15340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS15345	COG1597	lipid kinase activity
AS52_RS15355	COG0372	Belongs to the citrate synthase family
AS52_RS15360	COG0583	DNA-binding transcription factor activity
AS52_RS15375	COG2202	Pas domain
AS52_RS15375	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS15380	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS15410	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS15415	COG2261	transglycosylase associated protein
AS52_RS15425	COG0740	serine-type endopeptidase activity
AS52_RS15440	COG1027	Aspartate ammonia-lyase
AS52_RS15445	COG0252	asparaginase activity
AS52_RS15450	COG1396	sequence-specific DNA binding
AS52_RS15465	COG0640	Transcriptional regulator
AS52_RS15485	COG0531	amino acid
AS52_RS15490	COG1959	2 iron, 2 sulfur cluster binding
AS52_RS15510	COG0281	malic enzyme
AS52_RS15515	COG2746	aminoglycoside 3-N-acetyltransferase activity
AS52_RS15525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS15540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_RS15545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS52_RS15555	COG0477	Major facilitator Superfamily
AS52_RS15560	COG1846	Transcriptional regulator
AS52_RS15565	COG0789	Transcriptional regulator
AS52_RS15570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS15605	COG1819	glycosyl
AS52_RS15620	COG1902	pentaerythritol trinitrate reductase activity
AS52_RS15630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_RS15645	COG2814	Major facilitator Superfamily
AS52_RS15655	COG1228	amidohydrolase
AS52_RS15665	COG1316	TRANSCRIPTIONal
AS52_RS15670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS15690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS52_RS15700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS52_RS15755	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS15760	COG1280	lysine exporter protein (LysE YggA)
AS52_RS15765	COG0531	amino acid
AS52_RS15780	COG3764	Sortase (surface protein transpeptidase)
AS52_RS15785	COG0730	response to heat
AS52_RS15790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS15795	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AS52_RS15805	COG2130	NADP-dependent
AS52_RS15830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS15845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS52_RS15855	COG0501	Belongs to the peptidase M48B family
AS52_RS15890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AS52_RS15900	COG1309	transcriptional regulator
AS52_RS15905	COG2076	Multidrug Resistance protein
AS52_RS15910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AS52_RS15915	COG1278	Cold shock
AS52_RS15920	COG2323	membrane
AS52_RS15930	COG2910	NAD(P)H-binding
AS52_RS15955	COG4607	ABC-type enterochelin transport system periplasmic component
AS52_RS15960	COG4604	ABC transporter, ATP-binding protein
AS52_RS15965	COG4605	iron ion homeostasis
AS52_RS15970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS15980	COG3773	Cell wall hydrolase
AS52_RS15990	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_RS15995	COG0681	Belongs to the peptidase S26 family
AS52_RS16025	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AS52_RS16030	COG1396	sequence-specific DNA binding
AS52_RS16035	COG0861	Integral membrane protein TerC family
AS52_RS16040	COG1609	Transcriptional regulator
AS52_RS16045	COG1959	2 iron, 2 sulfur cluster binding
AS52_RS16105	COG3773	Cell wall hydrolase
AS52_RS16110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS52_RS16135	COG3546	catalase activity
AS52_RS16155	COG1280	lysine exporter protein (LysE YggA)
AS52_RS16160	COG1917	Cupin 2, conserved barrel domain protein
AS52_RS16160	COG2207	Transcriptional regulator
AS52_RS16165	COG4585	Histidine kinase
AS52_RS16185	COG3209	COG3209 Rhs family protein
AS52_RS16205	COG1819	glycosyl
AS52_RS16220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_RS16230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_RS16245	COG0346	lactoylglutathione lyase activity
AS52_RS16260	COG1136	(ABC) transporter
AS52_RS16265	COG0577	efflux transmembrane transporter activity
AS52_RS16270	COG5002	protein histidine kinase activity
AS52_RS16270	COG3850	Histidine kinase
AS52_RS16280	COG0384	phenazine biosynthesis protein PhzF
AS52_RS16295	COG5002	protein histidine kinase activity
AS52_RS16300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS16325	COG4989	oxidoreductase activity
AS52_RS16410	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AS52_RS16420	COG1301	dicarboxylic acid transport
AS52_RS16425	COG2824	Alkylphosphonate utilization operon protein PhnA
AS52_RS16455	COG0405	Gamma-glutamyltransferase
AS52_RS16460	COG1073	alpha beta
AS52_RS16475	COG0477	Major facilitator Superfamily
AS52_RS16480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS16495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS16505	COG1960	acyl-CoA dehydrogenase activity
AS52_RS16510	COG1063	alcohol dehydrogenase
AS52_RS16515	COG0745	RESPONSE REGULATOR receiver
AS52_RS16520	COG2205	protein histidine kinase activity
AS52_RS16525	COG1136	(ABC) transporter
AS52_RS16530	COG0577	efflux transmembrane transporter activity
AS52_RS16540	COG0412	Dienelactone hydrolase
AS52_RS16545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS16560	COG0730	response to heat
AS52_RS16565	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_RS16570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_RS16570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS16575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_RS16575	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_RS16585	COG1054	Belongs to the UPF0176 family
AS52_RS16590	COG2210	Belongs to the sulfur carrier protein TusA family
AS52_RS16595	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_RS16600	COG1937	Protein conserved in bacteria
AS52_RS16640	COG2188	Transcriptional regulator
AS52_RS16645	COG2723	6-phospho-beta-galactosidase activity
AS52_RS16670	COG1280	lysine exporter protein (LysE YggA)
AS52_RS16685	COG0583	DNA-binding transcription factor activity
AS52_RS16700	COG0346	lactoylglutathione lyase activity
AS52_RS16710	COG3706	GGDEF domain
AS52_RS16715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS52_RS16730	COG0778	Nitroreductase
AS52_RS16735	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS16750	COG1704	LemA family
AS52_RS16770	COG1733	regulation of RNA biosynthetic process
AS52_RS16775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_RS16780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_RS16785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_RS16800	COG2304	oxidoreductase activity
AS52_RS16810	COG0346	lactoylglutathione lyase activity
AS52_RS16815	COG2808	Putative FMN-binding domain
AS52_RS16850	COG4807	Protein conserved in bacteria
AS52_RS16860	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AS52_RS16865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS16870	COG1278	Cold shock
AS52_RS16875	COG1278	Cold shock
AS52_RS16890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS52_RS16895	COG1301	dicarboxylic acid transport
AS52_RS16900	COG2258	MOSC domain
AS52_RS16905	COG2807	transmembrane transport
AS52_RS16910	COG2186	Transcriptional regulator
AS52_RS16945	COG0659	secondary active sulfate transmembrane transporter activity
AS52_RS16955	COG0583	DNA-binding transcription factor activity
AS52_RS16960	COG1063	alcohol dehydrogenase
AS52_RS16980	COG1131	(ABC) transporter
AS52_RS17010	COG0772	Belongs to the SEDS family
AS52_RS17040	COG0561	phosphatase activity
AS52_RS17050	COG2312	Erythromycin esterase
AS52_RS17065	COG2329	Antibiotic biosynthesis monooxygenase
AS52_RS17080	COG5002	protein histidine kinase activity
AS52_RS17085	COG0745	RESPONSE REGULATOR receiver
AS52_RS17100	COG1131	(ABC) transporter
AS52_RS17115	COG0583	DNA-binding transcription factor activity
AS52_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS17135	COG1064	alcohol dehydrogenase
AS52_RS17140	COG0789	Transcriptional regulator
AS52_RS17155	COG0662	Cupin 2, conserved barrel domain protein
AS52_RS17175	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS17180	COG1278	Cold shock
AS52_RS17195	COG0840	transmembrane signaling receptor activity
AS52_RS17195	COG3290	protein histidine kinase activity
AS52_RS17200	COG5001	Diguanylate cyclase
AS52_RS17205	COG1876	peptidase activity
AS52_RS17225	COG0598	Magnesium transport protein CorA
AS52_RS17230	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS17260	COG4335	DNA alkylation repair
AS52_RS17265	COG0454	-acetyltransferase
AS52_RS17275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_RS17285	COG2186	Transcriptional regulator
AS52_RS17305	COG3619	membrane
AS52_RS17315	COG1349	DNA-binding transcription factor activity
AS52_RS17320	COG0561	phosphatase activity
AS52_RS17330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_RS17345	COG1280	lysine exporter protein (LysE YggA)
AS52_RS17370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_RS17370	COG3153	acetyltransferase
AS52_RS17380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS52_RS17405	COG2160	L-arabinose isomerase activity
AS52_RS17420	COG1609	Transcriptional regulator
AS52_RS17425	COG1078	dGTPase activity
AS52_RS17430	COG1999	signal sequence binding
AS52_RS17440	COG1131	(ABC) transporter
AS52_RS17480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_RS17485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_RS17490	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_RS17490	COG1918	ferrous iron import across plasma membrane
AS52_RS17515	COG1846	Transcriptional regulator
AS52_RS17545	COG0697	spore germination
AS52_RS17550	COG0583	DNA-binding transcription factor activity
AS52_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS17560	COG1388	LysM domain
AS52_RS17560	COG0791	NLP P60 protein
AS52_RS17565	COG2258	MOSC domain
AS52_RS17575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_RS17615	COG5646	InterPro IPR014922
AS52_RS17620	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AS52_RS17705	COG1074	ATP-dependent DNA helicase activity
AS52_RS17795	COG1278	Cold shock
AS52_RS17800	COG2814	Major facilitator Superfamily
AS52_RS17810	COG0583	DNA-binding transcription factor activity
AS52_RS17820	COG2807	transmembrane transport
AS52_RS17835	COG0604	alcohol dehydrogenase
AS52_RS17845	COG1733	regulation of RNA biosynthetic process
AS52_RS17860	COG1388	LysM domain
AS52_RS17870	COG2271	Major facilitator Superfamily
AS52_RS17875	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_RS17885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_RS17890	COG1414	Transcriptional regulator
AS52_RS17915	COG1335	isochorismatase
AS52_RS17920	COG0693	protein deglycase activity
AS52_RS17935	COG4978	Transcriptional regulator
AS52_RS17935	COG0789	Transcriptional regulator
AS52_RS17950	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS17955	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_RS17960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS17960	COG2190	(PTS) system
AS52_RS17960	COG1263	PTS System
AS52_RS17970	COG0523	cobalamin synthesis protein
AS52_RS17975	COG0717	Belongs to the dCTP deaminase family
AS52_RS17980	COG0523	cobalamin synthesis protein
AS52_RS17990	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS17995	COG2188	Transcriptional regulator
AS52_RS18005	COG1501	Belongs to the glycosyl hydrolase 31 family
AS52_RS18015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS52_RS18020	COG2211	Major facilitator Superfamily
AS52_RS18035	COG2311	Membrane
AS52_RS18080	COG0047	phosphoribosylformylglycinamidine synthase activity
AS52_RS18085	COG1522	sequence-specific DNA binding
AS52_RS18105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS18110	COG2267	carboxylic ester hydrolase activity
AS52_RS18120	COG1335	isochorismatase
AS52_RS18130	COG0346	lactoylglutathione lyase activity
AS52_RS18165	COG0477	Major facilitator Superfamily
AS52_RS18180	COG0477	Major facilitator Superfamily
AS52_RS18185	COG1309	transcriptional regulator
AS52_RS18195	COG4572	Cation transport regulator
AS52_RS18200	COG1621	beta-fructofuranosidase activity
AS52_RS18205	COG0366	Alpha amylase catalytic
AS52_RS18210	COG1609	Transcriptional regulator
AS52_RS18270	COG1266	CAAX protease self-immunity
AS52_RS18275	COG0156	8-amino-7-oxononanoate synthase activity
AS52_RS18290	COG2190	(PTS) system
AS52_RS18290	COG1263	PTS System
AS52_RS18290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS18295	COG0252	asparaginase activity
AS52_RS18310	COG0686	Belongs to the AlaDH PNT family
AS52_RS18325	COG1695	Transcriptional regulator
AS52_RS18335	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS18340	COG5002	protein histidine kinase activity
AS52_RS18345	COG0745	RESPONSE REGULATOR receiver
AS52_RS18350	COG0745	RESPONSE REGULATOR receiver
AS52_RS18365	COG0583	DNA-binding transcription factor activity
AS52_RS18375	COG2814	Major facilitator Superfamily
AS52_RS18380	COG0110	maltose O-acetyltransferase activity
AS52_RS18390	COG3620	sequence-specific DNA binding
AS52_RS18435	COG2801	Transposase and inactivated derivatives
AS52_RS18480	COG1971	Probably functions as a manganese efflux pump
AS52_RS18485	COG3339	Conserved Protein
AS52_RS18500	COG3708	Transcriptional regulator
AS52_RS18500	COG2207	Transcriptional regulator
AS52_RS18510	COG1733	regulation of RNA biosynthetic process
AS52_RS18530	COG0303	'Molybdopterin
AS52_RS18540	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS52_RS18545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS52_RS18550	COG1079	Belongs to the binding-protein-dependent transport system permease family
AS52_RS18555	COG4603	Belongs to the binding-protein-dependent transport system permease family
AS52_RS18560	COG3845	ABC transporter
AS52_RS18590	COG2828	Protein conserved in bacteria
AS52_RS18595	COG0583	DNA-binding transcription factor activity
AS52_RS18600	COG2851	Citrate transporter
AS52_RS18620	COG0670	Belongs to the BI1 family
AS52_RS18640	COG0791	NLP P60 protein
AS52_RS18645	COG2814	Major facilitator Superfamily
AS52_RS18650	COG1846	Transcriptional regulator
AS52_RS18665	COG1278	Cold shock
AS52_RS18675	COG1113	amino acid transport
AS52_RS18680	COG1113	amino acid transport
AS52_RS18685	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS18690	COG0506	proline dehydrogenase activity
AS52_RS18695	COG3878	Protein conserved in bacteria
AS52_RS18710	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS18715	COG3300	MHYT domain
AS52_RS18715	COG5001	Diguanylate cyclase
AS52_RS18750	COG4640	response to antibiotic
AS52_RS18765	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS52_RS18770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS52_RS18795	COG1247	-acetyltransferase
AS52_RS18810	COG0789	Transcriptional regulator
AS52_RS18815	COG0667	Aldo Keto reductase
AS52_RS18825	COG0789	Transcriptional regulator
AS52_RS18840	COG1621	beta-fructofuranosidase activity
AS52_RS18845	COG4980	gas vesicle protein
AS52_RS18870	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_RS18875	COG0577	efflux transmembrane transporter activity
AS52_RS18880	COG1136	(ABC) transporter
AS52_RS18890	COG0642	Histidine kinase
AS52_RS18895	COG0745	RESPONSE REGULATOR receiver
AS52_RS18905	COG1289	transmembrane transporter activity
AS52_RS18910	COG1937	Protein conserved in bacteria
AS52_RS18915	COG3209	COG3209 Rhs family protein
AS52_RS18930	COG3973	AAA domain
AS52_RS18935	COG1024	Enoyl-CoA hydratase
AS52_RS18940	COG1733	regulation of RNA biosynthetic process
AS52_RS18945	COG2124	cytochrome p450
AS52_RS18950	COG2259	Doxx family
AS52_RS18955	COG0463	Glycosyl transferase, family 2
AS52_RS18965	COG0463	Glycosyl transferase, family 2
AS52_RS18980	COG0791	NLP P60 protein
AS52_RS18980	COG1388	LysM domain
AS52_RS18985	COG0840	transmembrane signaling receptor activity
AS52_RS18990	COG1846	Transcriptional regulator
AS52_RS19000	COG1595	DNA-templated transcription, initiation
AS52_RS19005	COG0726	polysaccharide deacetylase
AS52_RS19010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_RS19020	COG0697	spore germination
AS52_RS19035	COG0833	amino acid
AS52_RS19050	COG0405	Gamma-glutamyltransferase
AS52_RS19060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS52_RS19065	COG0569	domain protein
AS52_RS19075	COG1522	sequence-specific DNA binding
AS52_RS19085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_RS19090	COG0745	RESPONSE REGULATOR receiver
AS52_RS19095	COG2770	Histidine kinase
AS52_RS19095	COG2205	protein histidine kinase activity
AS52_RS19100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS52_RS19105	COG1607	acyl-coa hydrolase
AS52_RS19110	COG1802	Transcriptional regulator
AS52_RS19115	COG0697	spore germination
AS52_RS19125	COG0006	proline dipeptidase activity
AS52_RS19145	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_RS19150	COG5522	Integral membrane protein (intg_mem_TP0381)
AS52_RS19155	COG1174	glycine betaine transport
AS52_RS19160	COG0517	IMP dehydrogenase activity
AS52_RS19160	COG1125	glycine betaine transport
AS52_RS19175	COG2814	Major facilitator Superfamily
AS52_RS19185	COG0395	ABC-type sugar transport system, permease component
AS52_RS19195	COG1653	transport
AS52_RS19205	COG1609	Transcriptional regulator
AS52_RS19210	COG2205	protein histidine kinase activity
AS52_RS19215	COG0730	response to heat
AS52_RS19220	COG1301	dicarboxylic acid transport
AS52_RS19235	COG0753	catalase activity
AS52_RS19260	COG1368	sulfuric ester hydrolase activity
AS52_RS19270	COG0697	spore germination
AS52_RS19275	COG1902	pentaerythritol trinitrate reductase activity
AS52_RS19290	COG1113	amino acid transport
AS52_RS19295	COG5505	Protein of unknown function (DUF819)
AS52_RS19300	COG1309	transcriptional regulator
AS52_RS19310	COG0583	DNA-binding transcription factor activity
AS52_RS19315	COG0730	response to heat
AS52_RS19320	COG1247	-acetyltransferase
AS52_RS19325	COG2910	NAD(P)H-binding
AS52_RS19330	COG1285	pathogenesis
AS52_RS19335	COG4195	phage-related replication protein
AS52_RS19345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_RS19360	COG1113	amino acid transport
AS52_RS19385	COG0463	Glycosyl transferase, family 2
AS52_RS19405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AS52_RS19410	COG2514	catechol 2,3-dioxygenase activity
AS52_RS19430	COG1280	lysine exporter protein (LysE YggA)
AS52_RS19435	COG1115	amino acid carrier protein
AS52_RS19445	COG0385	Bile acid
AS52_RS19450	COG0668	transmembrane transport
AS52_RS19455	COG2340	Cysteine-rich secretory protein family
AS52_RS19460	COG1253	flavin adenine dinucleotide binding
AS52_RS19470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS52_RS19475	COG0589	response to stress
AS52_RS19480	COG0205	6-phosphofructokinase activity
AS52_RS19485	COG1388	LysM domain
AS52_RS19485	COG0791	NLP P60 protein
AS52_RS19500	COG0432	Pfam Uncharacterised protein family UPF0047
AS52_RS19505	COG0697	spore germination
AS52_RS19510	COG0814	amino acid
AS52_RS19535	COG1131	(ABC) transporter
AS52_RS19550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_RS19565	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_RS19575	COG3842	ATPase activity
AS52_RS19590	COG0706	membrane insertase activity
AS52_RS19600	COG1263	PTS System
AS52_RS19600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS19605	COG3711	transcriptional antiterminator
AS52_RS19610	COG2190	(PTS) system
AS52_RS19615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_RS19630	COG0772	Belongs to the SEDS family
AS52_RS19635	COG0659	secondary active sulfate transmembrane transporter activity
AS52_RS19640	COG0813	purine-nucleoside phosphorylase activity
AS52_RS19650	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS19655	COG4326	sporulation control protein
AS52_RS19660	COG0515	serine threonine protein kinase
AS52_RS19675	COG4479	Belongs to the UPF0346 family
AS52_RS19680	COG3594	Acyltransferase
AS52_RS19695	COG1509	lysine 2,3-aminomutase activity
AS52_RS19700	COG0456	acetyltransferase
AS52_RS19705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_RS19710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS52_RS19715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_RS19720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_RS19725	COG1301	dicarboxylic acid transport
AS52_RS19735	COG4191	Histidine kinase
AS52_RS19755	COG2755	lipolytic protein G-D-S-L family
AS52_RS19760	COG1999	signal sequence binding
AS52_RS19770	COG1307	EDD domain protein, DegV family
AS52_RS19780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS52_RS19790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS52_RS19795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS52_RS19800	COG0788	formyltetrahydrofolate deformylase activity
AS52_RS19830	COG0076	glutamate decarboxylase activity
AS52_RS19850	COG0415	Belongs to the DNA photolyase family
AS52_RS19855	COG3852	Histidine kinase
AS52_RS19870	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS19880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS52_RS19890	COG4846	Membrane protein involved in cytochrome C biogenesis
AS52_RS19895	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AS52_RS19900	COG0785	Cytochrome C biogenesis protein
AS52_RS19910	COG1132	(ABC) transporter
AS52_RS19915	COG1132	(ABC) transporter
AS52_RS19935	COG4224	UPF0291 protein
AS52_RS19940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS52_RS19970	COG0463	Glycosyl transferase, family 2
AS52_RS19975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_RS19980	COG0531	amino acid
AS52_RS19990	COG0174	glutamine synthetase
AS52_RS19995	COG0789	Transcriptional regulator
AS52_RS20000	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AS52_RS20005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS52_RS20010	COG2860	membrane
AS52_RS20015	COG0464	growth
AS52_RS20025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AS52_RS20035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AS52_RS20040	COG0531	amino acid
AS52_RS20050	COG4550	Control of competence regulator ComK, YlbF/YmcA
AS52_RS20055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS52_RS20060	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS52_RS20065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS52_RS20065	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS52_RS20075	COG2359	stage V sporulation protein S
AS52_RS20080	COG1692	metallophosphoesterase
AS52_RS20090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS52_RS20095	COG1058	Belongs to the CinA family
AS52_RS20095	COG1546	Belongs to the CinA family
AS52_RS20100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS52_RS20105	COG1426	Protein conserved in bacteria
AS52_RS20120	COG0300	oxidoreductase activity
AS52_RS20125	COG0612	Peptidase, M16
AS52_RS20130	COG0612	Peptidase, M16
AS52_RS20135	COG1079	Belongs to the binding-protein-dependent transport system permease family
AS52_RS20140	COG4603	Belongs to the binding-protein-dependent transport system permease family
AS52_RS20145	COG3845	ABC transporter
AS52_RS20150	COG1744	ABC transporter substrate-binding protein PnrA-like
AS52_RS20155	COG2188	Transcriptional regulator
AS52_RS20160	COG4980	gas vesicle protein
AS52_RS20160	COG1674	ftsk spoiiie
AS52_RS20170	COG0740	serine-type endopeptidase activity
AS52_RS20175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_RS20185	COG0527	aspartate kinase activity
AS52_RS20190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS52_RS20195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS52_RS20200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_RS20205	COG1873	PFAM PRC-barrel domain
AS52_RS20210	COG0612	Peptidase, M16
AS52_RS20215	COG0726	polysaccharide deacetylase
AS52_RS20220	COG1185	polyribonucleotide nucleotidyltransferase activity
AS52_RS20225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AS52_RS20230	COG0196	riboflavin kinase activity
AS52_RS20240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS52_RS20245	COG1550	Protein conserved in bacteria
AS52_RS20255	COG1358	cellular component organization or biogenesis
AS52_RS20260	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AS52_RS20265	COG0195	Participates in both transcription termination and antitermination
AS52_RS20270	COG0779	Required for maturation of 30S ribosomal subunits
AS52_RS20275	COG2176	DNA-directed DNA polymerase activity
AS52_RS20280	COG0442	prolyl-tRNA aminoacylation
AS52_RS20285	COG0750	zinc metalloprotease
AS52_RS20295	COG4589	Belongs to the CDS family
AS52_RS20300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS52_RS20305	COG0233	cytoplasmic translational termination
AS52_RS20315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS52_RS20330	COG1191	sigma factor activity
AS52_RS20335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AS52_RS20340	COG0835	chemotaxis
AS52_RS20345	COG2198	Histidine kinase
AS52_RS20345	COG0643	Histidine kinase
AS52_RS20350	COG2201	protein-glutamate methylesterase activity
AS52_RS20355	COG0455	bacterial-type flagellum organization
AS52_RS20360	COG1419	protein localization to endoplasmic reticulum
AS52_RS20365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS52_RS20370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS52_RS20375	COG1684	flagellar biosynthetic protein fliR
AS52_RS20380	COG1987	bacterial-type flagellum assembly
AS52_RS20385	COG1338	Plays a role in the flagellum-specific transport system
AS52_RS20390	COG3190	flagellar
AS52_RS20395	COG2201	protein-glutamate methylesterase activity
AS52_RS20400	COG1776	CheC inhibitor of MCP methylation
AS52_RS20400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_RS20405	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_RS20415	COG1582	Flagellar protein (FlbD)
AS52_RS20420	COG4786	Flagellar basal body rod
AS52_RS20425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AS52_RS20440	COG2882	bacterial-type flagellum organization
AS52_RS20445	COG1157	protein secretion by the type III secretion system
AS52_RS20450	COG1317	bacterial-type flagellum organization
AS52_RS20455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_RS20460	COG1766	The M ring may be actively involved in energy transduction
AS52_RS20465	COG1677	Flagellar hook-basal body complex protein FliE
AS52_RS20470	COG1558	bacterial-type flagellum-dependent cell motility
AS52_RS20475	COG1815	bacterial-type flagellum-dependent cell motility
AS52_RS20480	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AS52_RS20485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AS52_RS20495	COG4974	Belongs to the 'phage' integrase family
AS52_RS20500	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AS52_RS20505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS52_RS20510	COG0758	DNA mediated transformation
AS52_RS20515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS52_RS20520	COG0045	succinate-CoA ligase (ADP-forming) activity
AS52_RS20540	COG0335	large ribosomal subunit rRNA binding
AS52_RS20550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS52_RS20560	COG1837	Belongs to the UPF0109 family
AS52_RS20565	COG0228	four-way junction DNA binding
AS52_RS20570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS52_RS20580	COG0552	protein localization to endoplasmic reticulum
AS52_RS20585	COG1196	nuclear chromosome segregation
AS52_RS20590	COG0571	ribonuclease III activity
AS52_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS20605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AS52_RS20610	COG0416	fatty acid biosynthetic process
AS52_RS20615	COG1349	DNA-binding transcription factor activity
AS52_RS20620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS52_RS20625	COG1760	l-serine dehydratase
AS52_RS20630	COG1760	l-serine dehydratase
AS52_RS20640	COG1461	Dihydroxyacetone kinase
AS52_RS20645	COG1302	Protein conserved in bacteria
AS52_RS20650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AS52_RS20660	COG1564	THIamine pyrophosphokinase
AS52_RS20665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS52_RS20670	COG1162	GTPase activity
AS52_RS20675	COG2815	serine threonine protein kinase
AS52_RS20675	COG0515	serine threonine protein kinase
AS52_RS20680	COG0631	protein serine/threonine phosphatase activity
AS52_RS20690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS52_RS20690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS52_RS20695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS52_RS20705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS52_RS20710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS52_RS20715	COG1758	RNA polymerase activity
AS52_RS20720	COG0194	GDP metabolic process
AS52_RS20725	COG2052	Domain of unknown function (DUF370)
AS52_RS20730	COG1561	YicC-like family, N-terminal region
AS52_RS20735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS52_RS20745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AS52_RS20760	COG0543	2 iron, 2 sulfur cluster binding
AS52_RS20775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS52_RS20780	COG0540	Belongs to the ATCase OTCase family
AS52_RS20790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AS52_RS20795	COG0564	pseudouridine synthase activity
AS52_RS20800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS52_RS20815	COG3599	regulation of cell shape
AS52_RS20820	COG2302	S4 RNA-binding domain
AS52_RS20825	COG0762	integral membrane protein
AS52_RS20830	COG1799	cell septum assembly
AS52_RS20835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS52_RS20845	COG1873	PFAM PRC-barrel domain
AS52_RS20850	COG1191	sigma factor activity
AS52_RS20855	COG1191	sigma factor activity
AS52_RS20865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS52_RS20870	COG0849	cell division
AS52_RS20875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS52_RS20880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS52_RS20885	COG0772	Belongs to the SEDS family
AS52_RS20890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AS52_RS20895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS52_RS20905	COG0768	penicillin binding
AS52_RS20910	COG0768	penicillin binding
AS52_RS20915	COG4839	cell division protein FtsL
AS52_RS20925	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AS52_RS20935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS52_RS20940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS52_RS20945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS52_RS20950	COG0439	Biotin carboxylase
AS52_RS20955	COG0454	-acetyltransferase
AS52_RS20965	COG1024	Enoyl-CoA hydratase
AS52_RS20970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS52_RS20975	COG1399	metal-binding, possibly nucleic acid-binding protein
AS52_RS20980	COG1323	Belongs to the UPF0348 family
AS52_RS20985	COG3480	Lon protease (S16) C-terminal proteolytic domain
AS52_RS20990	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_RS20995	COG3314	Sporulation integral membrane protein YlbJ
AS52_RS21000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS52_RS21005	COG0742	ribosomal rna small subunit methyltransferase
AS52_RS21015	COG4471	UPF0298 protein
AS52_RS21025	COG3679	Belongs to the UPF0342 family
AS52_RS21045	COG4347	Protein of unknown function (DUF1405)
AS52_RS21055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS52_RS21070	COG5582	Belongs to the UPF0302 family
AS52_RS21075	COG0457	Tetratricopeptide repeat
AS52_RS21085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS52_RS21090	COG0287	Prephenate dehydrogenase
AS52_RS21095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS52_RS21100	COG0159	tryptophan synthase activity
AS52_RS21110	COG0134	indole-3-glycerol-phosphate synthase activity
AS52_RS21115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS52_RS21125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AS52_RS21130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS52_RS21135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS52_RS21140	COG0105	UTP biosynthetic process
AS52_RS21145	COG0142	geranyltranstransferase activity
AS52_RS21150	COG2226	methyltransferase
AS52_RS21155	COG0142	geranyltranstransferase activity
AS52_RS21165	COG0302	gtp cyclohydrolase
AS52_RS21170	COG0776	regulation of translation
AS52_RS21175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS52_RS21205	COG2271	Major facilitator Superfamily
AS52_RS21210	COG1304	FMN binding
AS52_RS21215	COG0539	negative regulation of cytoplasmic translation
AS52_RS21225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS52_RS21235	COG2959	enzyme of heme biosynthesis
AS52_RS21240	COG3773	Cell wall hydrolase
AS52_RS21240	COG3409	Peptidoglycan-binding domain 1 protein
AS52_RS21245	COG2339	peptidase activity
AS52_RS21250	COG0252	asparaginase activity
AS52_RS21255	COG0492	ferredoxin-NADP+ reductase activity
AS52_RS21260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS52_RS21265	COG4862	establishment of competence for transformation
AS52_RS21270	COG0789	Transcriptional regulator
AS52_RS21275	COG1408	metallophosphoesterase
AS52_RS21290	COG1266	CAAX protease self-immunity
AS52_RS21295	COG0514	ATP-dependent DNA helicase (RecQ)
AS52_RS21305	COG1141	Ferredoxin
AS52_RS21310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AS52_RS21315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_RS21320	COG0739	heme binding
AS52_RS21325	COG5002	protein histidine kinase activity
AS52_RS21330	COG0745	RESPONSE REGULATOR receiver
AS52_RS21335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS52_RS21340	COG1333	cytochrome c biogenesis protein
AS52_RS21345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS21350	COG1187	pseudouridine synthase activity
AS52_RS21355	COG0700	Nucleoside recognition
AS52_RS21360	COG2715	membrane protein required for spore maturation
AS52_RS21365	COG1686	Belongs to the peptidase S11 family
AS52_RS21370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS52_RS21375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS52_RS21380	COG1547	Domain of unknown function (DUF309)
AS52_RS21390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS52_RS21395	COG4086	secreted protein
AS52_RS21405	COG0697	spore germination
AS52_RS21420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS52_RS21455	COG1686	Belongs to the peptidase S11 family
AS52_RS21470	COG4974	Belongs to the 'phage' integrase family
AS52_RS21480	COG0735	belongs to the Fur family
AS52_RS21485	COG1300	Membrane
AS52_RS21490	COG0494	nUDIX hydrolase
AS52_RS21500	COG0667	Aldo Keto reductase
AS52_RS21515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_RS21525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS52_RS21530	COG1073	alpha beta
AS52_RS21545	COG0300	oxidoreductase activity
AS52_RS21550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS21555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_RS21560	COG1902	pentaerythritol trinitrate reductase activity
AS52_RS21570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_RS21575	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS21580	COG2508	Transcriptional regulator
AS52_RS21600	COG0167	dihydroorotate dehydrogenase activity
AS52_RS21600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AS52_RS21605	COG0493	'glutamate synthase
AS52_RS21610	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS52_RS21615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS52_RS21625	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_RS21630	COG4129	membrane
AS52_RS21635	COG1126	abc transporter atp-binding protein
AS52_RS21640	COG0765	amino acid transport
AS52_RS21645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_RS21655	COG1703	isobutyryl-CoA mutase activity
AS52_RS21660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS21660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS21665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS21665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS21670	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_RS21675	COG0022	dehydrogenase e1 component
AS52_RS21680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS52_RS21685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS52_RS21700	COG0280	phosphate acetyltransferase
AS52_RS21705	COG3290	protein histidine kinase activity
AS52_RS21705	COG3829	transcription factor binding
AS52_RS21715	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_RS21720	COG3104	oligopeptide transport
AS52_RS21725	COG0745	RESPONSE REGULATOR receiver
AS52_RS21730	COG0750	zinc metalloprotease
AS52_RS21735	COG0497	DNA recombination
AS52_RS21745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AS52_RS21760	COG1722	exodeoxyribonuclease VII activity
AS52_RS21770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS52_RS21775	COG1302	Protein conserved in bacteria
AS52_RS21780	COG0439	Biotin carboxylase
AS52_RS21785	COG0511	ligase activity, forming carbon-carbon bonds
AS52_RS21825	COG3854	ATPases associated with a variety of cellular activities
AS52_RS21835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS52_RS21840	COG0006	proline dipeptidase activity
AS52_RS21845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AS52_RS21855	COG3872	metal-dependent enzyme
AS52_RS21865	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_RS21870	COG1321	iron dependent repressor
AS52_RS21875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_RS21880	COG0095	Lipoate-protein ligase
AS52_RS21885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_RS21895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS52_RS21900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS52_RS21905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS52_RS21935	COG4970	Tfp pilus assembly protein FimT
AS52_RS21940	COG4537	Required for transformation and DNA binding
AS52_RS21945	COG1459	type II secretion system
AS52_RS21950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS52_RS21955	COG1393	Belongs to the ArsC family
AS52_RS21965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS21975	COG2866	Carboxypeptidase
AS52_RS21980	COG1940	carbohydrate kinase activity
AS52_RS21985	COG4483	Protein conserved in bacteria
AS52_RS21990	COG0705	Rhomboid family
AS52_RS21990	COG0457	Tetratricopeptide repeat
AS52_RS22000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS52_RS22010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS52_RS22025	COG0704	Plays a role in the regulation of phosphate uptake
AS52_RS22035	COG0768	penicillin binding
AS52_RS22040	COG0477	Major facilitator Superfamily
AS52_RS22075	COG2839	Protein conserved in bacteria
AS52_RS22090	COG2814	Major facilitator Superfamily
AS52_RS22095	COG1388	LysM domain
AS52_RS22100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AS52_RS22105	COG4709	membrane
AS52_RS22110	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AS52_RS22115	COG0735	belongs to the Fur family
AS52_RS22120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS52_RS22125	COG1121	(ABC) transporter
AS52_RS22135	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AS52_RS22140	COG0513	Belongs to the DEAD box helicase family
AS52_RS22150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AS52_RS22155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS52_RS22160	COG2384	SAM-dependent methyltransferase
AS52_RS22165	COG2010	Cytochrome c
AS52_RS22170	COG1960	acyl-CoA dehydrogenase activity
AS52_RS22175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS52_RS22180	COG0358	DNA primase activity
AS52_RS22185	COG1671	Belongs to the UPF0178 family
AS52_RS22190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AS52_RS22195	COG0517	IMP dehydrogenase activity
AS52_RS22205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS52_RS22210	COG0295	cytidine deaminase activity
AS52_RS22215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AS52_RS22225	COG1480	7TM receptor with intracellular HD hydrolase
AS52_RS22230	COG1702	phosphate starvation-inducible protein PhoH
AS52_RS22255	COG1030	water channel activity
AS52_RS22260	COG1610	YqeY-like protein
AS52_RS22270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS52_RS22275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS52_RS22280	COG2264	protein methyltransferase activity
AS52_RS22295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AS52_RS22300	COG1420	regulation of RNA biosynthetic process
AS52_RS22305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS52_RS22310	COG0481	GTPase activity
AS52_RS22320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AS52_RS22325	COG0268	Binds directly to 16S ribosomal RNA
AS52_RS22330	COG1466	dna polymerase III delta subunit
AS52_RS22340	COG2333	competence protein COMEC
AS52_RS22340	COG0658	competence protein
AS52_RS22345	COG2131	deaminase
AS52_RS22350	COG1555	photosystem II stabilization
AS52_RS22350	COG1596	polysaccharide export
AS52_RS22355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_RS22360	COG2226	methyltransferase
AS52_RS22365	COG0799	negative regulation of ribosome biogenesis
AS52_RS22370	COG1713	HD superfamily hydrolase involved in NAD metabolism
AS52_RS22375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS52_RS22380	COG1534	Rna-binding protein
AS52_RS22385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS52_RS22390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AS52_RS22395	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AS52_RS22405	COG0688	phosphatidylethanolamine metabolic process
AS52_RS22410	COG1183	phosphatidylcholine synthase activity
AS52_RS22425	COG0626	cystathionine gamma-synthase activity
AS52_RS22430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_RS22435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS52_RS22440	COG2226	methyltransferase
AS52_RS22455	COG0768	penicillin binding
AS52_RS22460	COG1335	isochorismatase
AS52_RS22465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS52_RS22470	COG0572	uridine kinase
AS52_RS22475	COG0826	peptidase U32
AS52_RS22480	COG0826	peptidase U32
AS52_RS22485	COG4122	O-methyltransferase activity
AS52_RS22490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS52_RS22495	COG3906	Belongs to the UPF0473 family
AS52_RS22505	COG4472	Bacterial protein of unknown function (DUF965)
AS52_RS22515	COG0628	permease
AS52_RS22525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS52_RS22535	COG0482	sulfurtransferase activity
AS52_RS22540	COG1104	cysteine desulfurase activity
AS52_RS22545	COG1959	2 iron, 2 sulfur cluster binding
AS52_RS22550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS52_RS22555	COG0581	inorganic phosphate transmembrane transporter activity
AS52_RS22560	COG0573	inorganic phosphate transmembrane transporter activity
AS52_RS22565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS52_RS22570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS52_RS22575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS52_RS22580	COG0124	histidyl-tRNA synthetase
AS52_RS22590	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_RS22595	COG1490	D-aminoacyl-tRNA deacylase activity
AS52_RS22600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS52_RS22605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_RS22610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS52_RS22610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AS52_RS22615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS52_RS22615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS52_RS22625	COG2244	polysaccharide biosynthetic process
AS52_RS22630	COG2323	membrane
AS52_RS22640	COG1862	Preprotein translocase
AS52_RS22645	COG0343	queuine tRNA-ribosyltransferase activity
AS52_RS22650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AS52_RS22660	COG2255	four-way junction helicase activity
AS52_RS22665	COG0632	four-way junction helicase activity
AS52_RS22690	COG1388	LysM domain
AS52_RS22695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AS52_RS22700	COG0157	Belongs to the NadC ModD family
AS52_RS22705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS52_RS22710	COG1104	cysteine desulfurase activity
AS52_RS22715	COG1827	regulation of RNA biosynthetic process
AS52_RS22720	COG0077	Prephenate dehydratase
AS52_RS22725	COG4492	Belongs to the UPF0735 family
AS52_RS22730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS52_RS22735	COG3290	protein histidine kinase activity
AS52_RS22745	COG2868	ribosomal protein
AS52_RS22755	COG1530	ribonuclease E activity
AS52_RS22760	COG1994	Peptidase M50
AS52_RS22765	COG0739	heme binding
AS52_RS22770	COG2894	cell division
AS52_RS22775	COG0850	regulation of cytokinetic process
AS52_RS22780	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AS52_RS22785	COG1792	Involved in formation and maintenance of cell shape
AS52_RS22790	COG1077	Cell shape determining protein MreB Mrl
AS52_RS22795	COG2003	Belongs to the UPF0758 family
AS52_RS22800	COG0424	maF-like protein
AS52_RS22810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS52_RS22820	COG2322	membrane
AS52_RS22825	COG0285	dihydrofolate synthase activity
AS52_RS22830	COG0525	valine-tRNA ligase activity
AS52_RS22840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS52_RS22845	COG1388	LysM domain
AS52_RS22850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS52_RS22855	COG0113	porphobilinogen synthase activity
AS52_RS22860	COG1587	Uroporphyrinogen-III synthase
AS52_RS22865	COG0181	hydroxymethylbilane synthase activity
AS52_RS22870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS52_RS22885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AS52_RS22890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AS52_RS22895	COG1067	ATP-dependent peptidase activity
AS52_RS22895	COG0470	DNA polymerase III
AS52_RS22900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AS52_RS22905	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS52_RS22910	COG0457	Tetratricopeptide repeat
AS52_RS22910	COG1477	protein flavinylation
AS52_RS22915	COG0066	3-isopropylmalate dehydratase activity
AS52_RS22920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS52_RS22930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS52_RS22935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS52_RS22940	COG0440	acetolactate synthase activity
AS52_RS22945	COG0028	Belongs to the TPP enzyme family
AS52_RS22955	COG0622	Phosphoesterase
AS52_RS22960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS52_RS22970	COG5401	PFAM Sporulation and spore germination
AS52_RS22975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS52_RS22980	COG1846	Transcriptional regulator
AS52_RS22990	COG0306	phosphate transporter
AS52_RS22995	COG1392	Phosphate transport regulator
AS52_RS23000	COG0768	penicillin binding
AS52_RS23010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_RS23015	COG0431	NADPH-dependent FMN reductase
AS52_RS23020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_RS23025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_RS23030	COG1116	anion transmembrane transporter activity
AS52_RS23035	COG0475	glutathione-regulated potassium exporter activity
AS52_RS23040	COG0490	domain, Protein
AS52_RS23050	COG2197	response regulator
AS52_RS23055	COG0824	Thioesterase
AS52_RS23060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS52_RS23065	COG1053	succinate dehydrogenase
AS52_RS23070	COG2009	succinate dehydrogenase
AS52_RS23075	COG1719	4-vinyl reductase, 4VR
AS52_RS23080	COG0527	aspartate kinase activity
AS52_RS23090	COG3118	belongs to the thioredoxin family
AS52_RS23095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS52_RS23100	COG2086	electron transfer activity
AS52_RS23105	COG1024	Enoyl-CoA hydratase
AS52_RS23110	COG1309	transcriptional regulator
AS52_RS23115	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS23120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS52_RS23125	COG3766	membrane
AS52_RS23130	COG1193	negative regulation of DNA recombination
AS52_RS23135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_RS23135	COG1796	DNA polymerase
AS52_RS23140	COG1286	toxin biosynthetic process
AS52_RS23145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AS52_RS23150	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS52_RS23155	COG0072	phenylalanine-tRNA ligase activity
AS52_RS23155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS52_RS23160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AS52_RS23165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS52_RS23175	COG1363	Peptidase, m42
AS52_RS23195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS52_RS23200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS52_RS23205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS52_RS23210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS52_RS23220	COG1484	DNA-dependent DNA replication
AS52_RS23225	COG3611	Membrane attachment protein
AS52_RS23230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS52_RS23240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS52_RS23245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS52_RS23255	COG1971	Probably functions as a manganese efflux pump
AS52_RS23260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS52_RS23265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_RS23265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_RS23270	COG5002	protein histidine kinase activity
AS52_RS23275	COG0745	RESPONSE REGULATOR receiver
AS52_RS23285	COG0039	L-malate dehydrogenase activity
AS52_RS23290	COG0538	isocitrate dehydrogenase activity
AS52_RS23295	COG0372	Belongs to the citrate synthase family
AS52_RS23300	COG2707	UPF0756 membrane protein
AS52_RS23305	COG0628	permease
AS52_RS23310	COG3030	protein affecting phage T7 exclusion by the F plasmid
AS52_RS23320	COG0825	malonyl-CoA metabolic process
AS52_RS23325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AS52_RS23330	COG2186	Transcriptional regulator
AS52_RS23335	COG0281	malic enzyme
AS52_RS23340	COG0587	DNA-directed DNA polymerase activity
AS52_RS23355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AS52_RS23365	COG4109	DRTGG domain
AS52_RS23375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS52_RS23385	COG0165	Argininosuccinate lyase
AS52_RS23390	COG0137	argininosuccinate synthase activity
AS52_RS23405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS52_RS23410	COG0827	DNA restriction-modification system
AS52_RS23415	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AS52_RS23420	COG3874	Sporulation protein YtfJ
AS52_RS23430	COG1714	RDD family
AS52_RS23435	COG0616	signal peptide processing
AS52_RS23440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS52_RS23445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS52_RS23455	COG0301	tRNA thio-modification
AS52_RS23460	COG1104	cysteine desulfurase activity
AS52_RS23465	COG1114	Component of the transport system for branched-chain amino acids
AS52_RS23470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AS52_RS23475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_RS23480	COG1309	transcriptional regulator
AS52_RS23485	COG1956	GAF domain-containing protein
AS52_RS23500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS52_RS23505	COG0454	-acetyltransferase
AS52_RS23510	COG0517	IMP dehydrogenase activity
AS52_RS23515	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS52_RS23535	COG1605	Chorismate mutase
AS52_RS23535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS52_RS23540	COG3118	belongs to the thioredoxin family
AS52_RS23545	COG4980	gas vesicle protein
AS52_RS23560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS52_RS23570	COG1674	ftsk spoiiie
AS52_RS23575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS52_RS23580	COG4848	Belongs to the UPF0354 family
AS52_RS23585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS23590	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AS52_RS23595	COG1363	Peptidase, m42
AS52_RS23600	COG5584	Small secreted protein
AS52_RS23605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_RS23610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS52_RS23620	COG0510	thiamine kinase activity
AS52_RS23625	COG1523	belongs to the glycosyl hydrolase 13 family
AS52_RS23635	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AS52_RS23640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_RS23645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_RS23650	COG1349	DNA-binding transcription factor activity
AS52_RS23655	COG1187	pseudouridine synthase activity
AS52_RS23660	COG2244	polysaccharide biosynthetic process
AS52_RS23665	COG2081	HI0933 family
AS52_RS23675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_RS23680	COG0495	leucyl-tRNA aminoacylation
AS52_RS23685	COG2610	gluconate transmembrane transporter activity
AS52_RS23690	COG2814	Major facilitator Superfamily
AS52_RS23705	COG1242	4 iron, 4 sulfur cluster binding
AS52_RS23710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AS52_RS23720	COG2267	carboxylic ester hydrolase activity
AS52_RS23725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS52_RS23730	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS23735	COG0438	transferase activity, transferring glycosyl groups
AS52_RS23735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_RS23740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS52_RS23745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AS52_RS23755	COG1506	peptidase
AS52_RS23760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_RS23765	COG1116	anion transmembrane transporter activity
AS52_RS23770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_RS23775	COG0494	nUDIX hydrolase
AS52_RS23785	COG4824	toxin secretion phage lysis holin
AS52_RS23790	COG0783	Belongs to the Dps family
AS52_RS23800	COG0288	reversible hydration of carbon dioxide
AS52_RS23805	COG0523	cobalamin synthesis protein
AS52_RS23815	COG0254	rRNA binding
AS52_RS23820	COG1271	oxidase subunit
AS52_RS23825	COG1294	oxidase, subunit
AS52_RS23830	COG0716	FMN binding
AS52_RS23850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_RS23855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_RS23860	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_RS23865	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS23870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS52_RS23875	COG0596	Alpha beta hydrolase
AS52_RS23880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS52_RS23885	COG1169	isochorismate synthase
AS52_RS23890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS52_RS23900	COG0058	SHG alpha-glucan phosphorylase activity
AS52_RS23905	COG0297	glycogen (starch) synthase activity
AS52_RS23910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS52_RS23915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS52_RS24045	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_RS24050	COG1285	pathogenesis
AS52_RS24070	COG0529	Catalyzes the synthesis of activated sulfate
AS52_RS24080	COG0306	phosphate transporter
AS52_RS24090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS52_RS24095	COG0346	lactoylglutathione lyase activity
AS52_RS24100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS52_RS24110	COG0166	Belongs to the GPI family
AS52_RS24120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS52_RS24120	COG2111	Na H antiporter
AS52_RS24125	COG2111	Na H antiporter
AS52_RS24130	COG1006	Multisubunit Na H antiporter MnhC subunit
AS52_RS24135	COG0651	ATP synthesis coupled electron transport
AS52_RS24140	COG1863	multisubunit Na H antiporter MnhE subunit
AS52_RS24145	COG2212	antiporter activity
AS52_RS24150	COG1320	monovalent cation:proton antiporter activity
AS52_RS24155	COG1979	alcohol dehydrogenase
AS52_RS24160	COG2155	Conserved Protein
AS52_RS24165	COG1098	S1 RNA binding domain
AS52_RS24170	COG0436	Aminotransferase
AS52_RS24175	COG1522	sequence-specific DNA binding
AS52_RS24180	COG2267	carboxylic ester hydrolase activity
AS52_RS24185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS52_RS24190	COG2032	superoxide dismutase activity
AS52_RS24205	COG5018	Exonuclease
AS52_RS24210	COG2050	protein possibly involved in aromatic compounds catabolism
AS52_RS24220	COG1418	mRNA catabolic process
AS52_RS24230	COG2056	Na+-H+ antiporter family
AS52_RS24235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS52_RS24240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AS52_RS24245	COG3584	3D domain protein
AS52_RS24255	COG1252	NADH dehydrogenase
AS52_RS24260	COG0492	ferredoxin-NADP+ reductase activity
AS52_RS24270	COG0316	Belongs to the HesB IscA family
AS52_RS24275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AS52_RS24280	COG4844	belongs to the
AS52_RS24285	COG1252	NADH dehydrogenase
AS52_RS24290	COG4837	Protein of unknown function (DUF1462)
AS52_RS24295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AS52_RS24300	COG0083	homoserine kinase activity
AS52_RS24305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS52_RS24310	COG0460	homoserine dehydrogenase
AS52_RS24315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_RS24320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS52_RS24325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS52_RS24330	COG0647	UMP catabolic process
AS52_RS24335	COG2445	Protein of unknown function DUF86
AS52_RS24345	COG4470	Protein conserved in bacteria
AS52_RS24355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS52_RS24360	COG0739	heme binding
AS52_RS24365	COG0733	neurotransmitter:sodium symporter activity
AS52_RS24375	COG3377	Domain of unknown function (DUF1805)
AS52_RS24380	COG1801	Protein of unknown function DUF72
AS52_RS24385	COG0719	Fe-S assembly protein
AS52_RS24390	COG0822	iron-sulfur transferase activity
AS52_RS24395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS52_RS24400	COG0719	Fe-S assembly protein
AS52_RS24405	COG0396	ATPase activity
AS52_RS24410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS52_RS24415	COG1464	Belongs to the NlpA lipoprotein family
AS52_RS24420	COG2011	ABC-type metal ion transport system permease component
AS52_RS24425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS52_RS24430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_RS24435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS52_RS24445	COG0509	glycine decarboxylation via glycine cleavage system
AS52_RS24450	COG1393	Belongs to the ArsC family
AS52_RS24455	COG1960	acyl-CoA dehydrogenase activity
AS52_RS24460	COG0183	Belongs to the thiolase family
AS52_RS24465	COG1024	Enoyl-CoA hydratase
AS52_RS24465	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_RS24485	COG1120	ATPase activity
AS52_RS24490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS24495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_RS24500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_RS24505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_RS24510	COG1309	transcriptional regulator
AS52_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_RS24525	COG0477	Major facilitator Superfamily
AS52_RS24530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS52_RS24535	COG0583	DNA-binding transcription factor activity
AS52_RS24545	COG0672	)-iron permease
AS52_RS24550	COG3850	Histidine kinase
AS52_RS24550	COG5002	protein histidine kinase activity
AS52_RS24555	COG0745	RESPONSE REGULATOR receiver
AS52_RS24560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_RS24565	COG0671	phosphoesterase, PA-phosphatase related
AS52_RS24570	COG1846	Transcriptional regulator
AS52_RS24575	COG0778	Nitroreductase
AS52_RS24580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AS52_RS24585	COG0314	molybdopterin synthase activity
AS52_RS24590	COG1763	Mo-molybdopterin cofactor biosynthetic process
AS52_RS24595	COG0303	'Molybdopterin
AS52_RS24600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_RS24605	COG0746	molybdenum cofactor guanylyltransferase activity
AS52_RS24615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS52_RS24620	COG5609	conserved protein (DUF2294)
AS52_RS24625	COG3383	formate dehydrogenase (NAD+) activity
AS52_RS24630	COG2427	Protein of unknown function (DUF1641)
AS52_RS24635	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS52_RS24640	COG4149	molybdate abc transporter
AS52_RS24645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS52_RS24650	COG0557	exoribonuclease II activity
AS52_RS24655	COG1647	Serine aminopeptidase, S33
AS52_RS24660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS52_RS24700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS52_RS24720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_RS24730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AS52_RS24735	COG1660	Displays ATPase and GTPase activities
AS52_RS24740	COG1051	belongs to the nudix hydrolase family
AS52_RS24745	COG0492	ferredoxin-NADP+ reductase activity
AS52_RS24750	COG0457	Tetratricopeptide repeat
AS52_RS24755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS52_RS24755	COG0140	phosphoribosyl-ATP diphosphatase activity
AS52_RS24760	COG0107	imidazoleglycerol-phosphate synthase activity
AS52_RS24765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AS52_RS24770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS52_RS24775	COG0131	Imidazoleglycerol-phosphate dehydratase
AS52_RS24780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS52_RS24785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS52_RS24790	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AS52_RS24795	COG0110	maltose O-acetyltransferase activity
AS52_RS24800	COG0546	phosphoglycolate phosphatase activity
AS52_RS24805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AS52_RS24810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AS52_RS24815	COG1950	PFAM Membrane protein of
AS52_RS24825	COG3595	metallopeptidase activity
AS52_RS24835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS52_RS24840	COG0556	nucleotide-excision repair
AS52_RS24845	COG2204	response regulator
AS52_RS24850	COG0506	proline dehydrogenase activity
AS52_RS24855	COG4897	Protein conserved in bacteria
AS52_RS24860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_RS24865	COG3409	Peptidoglycan-binding domain 1 protein
AS52_RS24865	COG0793	Belongs to the peptidase S41A family
AS52_RS24870	COG0739	heme binding
AS52_RS24875	COG2177	Part of the ABC transporter FtsEX involved in
AS52_RS24880	COG2884	Cell division ATP-binding protein ftsE
AS52_RS24885	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS52_RS24895	COG0805	protein transport
AS52_RS24900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_RS24905	COG3540	Alkaline phosphatase
AS52_RS24910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS52_RS24915	COG0653	protein targeting
AS52_RS24925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS52_RS24935	COG1516	flagellar protein fliS
AS52_RS24940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AS52_RS24950	COG1113	amino acid transport
AS52_RS24960	COG1012	belongs to the aldehyde dehydrogenase family
AS52_RS24965	COG1454	alcohol dehydrogenase
AS52_RS24970	COG1510	regulation of RNA biosynthetic process
AS52_RS24975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AS52_RS24980	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AS52_RS24985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS52_RS24990	COG4786	Flagellar basal body rod
AS52_RS24990	COG1256	bacterial-type flagellum assembly
AS52_RS25010	COG1040	competence protein
AS52_RS25015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AS52_RS25020	COG1307	EDD domain protein, DegV family
AS52_RS25025	COG1728	Protein conserved in bacteria
AS52_RS25035	COG2197	response regulator
AS52_RS25040	COG4585	Histidine kinase
AS52_RS25045	COG1739	Uncharacterized protein family UPF0029
AS52_RS25050	COG1316	TRANSCRIPTIONal
AS52_RS25055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS52_RS25060	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS52_RS25065	COG2268	Band 7 protein
AS52_RS25080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_RS25090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS52_RS25095	COG1388	LysM domain
AS52_RS25095	COG0791	NLP P60 protein
AS52_RS25100	COG0629	single-stranded DNA binding
AS52_RS25120	COG4786	Flagellar basal body rod
AS52_RS25125	COG4786	Flagellar basal body rod
AS52_RS25130	COG1077	Cell shape determining protein MreB Mrl
AS52_RS25135	COG1609	Transcriptional regulator
AS52_RS25140	COG0739	heme binding
AS52_RS25145	COG2385	sporulation resulting in formation of a cellular spore
AS52_RS25160	COG4836	Membrane
AS52_RS25165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AS52_RS25170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS52_RS25175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AS52_RS25180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS52_RS25185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS52_RS25190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AS52_RS25195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS52_RS25200	COG0356	it plays a direct role in the translocation of protons across the membrane
AS52_RS25215	COG1404	Belongs to the peptidase S8 family
AS52_RS25220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS52_RS25225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS52_RS25240	COG0698	ribose 5-phosphate isomerase
AS52_RS25250	COG1971	Probably functions as a manganese efflux pump
AS52_RS25255	COG0009	L-threonylcarbamoyladenylate synthase
AS52_RS25275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS52_RS25290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AS52_RS25300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS52_RS25305	COG0191	fructose-bisphosphate aldolase activity
AS52_RS25310	COG2204	response regulator
AS52_RS25315	COG4821	SIS domain
AS52_RS25320	COG0504	CTP synthase activity
AS52_RS25330	COG1703	isobutyryl-CoA mutase activity
AS52_RS25330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS25330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_RS25340	COG1960	acyl-CoA dehydrogenase activity
AS52_RS25345	COG1960	acyl-CoA dehydrogenase activity
AS52_RS25350	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_RS25355	COG0183	Belongs to the thiolase family
AS52_RS25360	COG0247	lactate metabolic process
AS52_RS25360	COG2181	nitrate reductase activity
AS52_RS25365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_RS25370	COG4294	response to UV
AS52_RS25375	COG0018	arginyl-trna synthetase
AS52_RS25385	COG0010	Belongs to the arginase family
AS52_RS25390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS52_RS25395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_RS25405	COG1994	Peptidase M50
AS52_RS25410	COG1942	4-Oxalocrotonate Tautomerase
AS52_RS25415	COG3465	dGTPase activity
AS52_RS25420	COG1078	dGTPase activity
AS52_RS25425	COG4844	belongs to the
AS52_RS25435	COG0095	Lipoate-protein ligase
AS52_RS25440	COG0280	phosphate acetyltransferase
AS52_RS25445	COG3253	May function as heme-dependent peroxidase
AS52_RS25450	COG3773	Cell wall hydrolase
AS52_RS25460	COG2363	Small membrane protein
AS52_RS25470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS52_RS25480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_RS25485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS52_RS25490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AS52_RS25490	COG2508	Transcriptional regulator
AS52_RS25495	COG0686	Belongs to the AlaDH PNT family
AS52_RS25505	COG0351	phosphomethylpyrimidine kinase
AS52_RS25510	COG0561	phosphatase activity
AS52_RS25515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS52_RS25520	COG1263	PTS System
AS52_RS25520	COG2190	(PTS) system
AS52_RS25520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_RS25530	COG0438	transferase activity, transferring glycosyl groups
AS52_RS25545	COG2076	Multidrug Resistance protein
AS52_RS25555	COG0728	peptidoglycan biosynthetic process
AS52_RS25570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AS52_RS25575	COG4988	ABC transporter
AS52_RS25580	COG1294	oxidase, subunit
AS52_RS25585	COG1271	oxidase subunit
AS52_RS25590	COG3610	response to peptide
AS52_RS25595	COG2966	Psort location CytoplasmicMembrane, score
AS52_RS25600	COG1609	Transcriptional regulator
AS52_RS25610	COG2814	Major facilitator Superfamily
AS52_RS25625	COG1966	Carbon starvation protein
AS52_RS25630	COG0753	catalase activity
AS52_RS25645	COG0471	metal ion transport
AS52_RS25650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS52_RS25665	COG3850	Histidine kinase
AS52_RS25665	COG5002	protein histidine kinase activity
AS52_RS25680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS52_RS25685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AS52_RS25690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_RS25695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AS52_RS25700	COG4853	Protein conserved in bacteria
AS52_RS25710	COG5002	protein histidine kinase activity
AS52_RS25715	COG0745	RESPONSE REGULATOR receiver
AS52_RS25740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS52_RS25745	COG0305	Participates in initiation and elongation during chromosome replication
AS52_RS25755	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AS52_RS25765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS52_RS25775	COG0360	Binds together with S18 to 16S ribosomal RNA
AS52_RS25780	COG0012	GTP binding
AS52_RS25785	COG4481	Protein conserved in bacteria
AS52_RS25790	COG0668	transmembrane transport
AS52_RS25795	COG3949	Membrane
AS52_RS25805	COG1475	DNA binding
AS52_RS25810	COG1192	Involved in chromosome partitioning
AS52_RS25815	COG1475	DNA binding
AS52_RS25825	COG0445	tRNA wobble uridine modification
AS52_RS25830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AS52_RS25835	COG1847	R3H domain protein
AS52_RS25840	COG0706	membrane insertase activity
AS52_RS25845	COG0594	ribonuclease P activity
AS52_RS25850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AS52_RS25855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS52_RS25860	COG0592	DNA-directed DNA polymerase activity
AS52_RS25865	COG2501	S4 domain
AS52_RS25870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AS52_RS25875	COG0187	DNA topoisomerase II activity
AS52_RS25880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS52_RS25915	COG0516	GMP reductase activity
AS52_RS25915	COG0517	IMP dehydrogenase activity
AS52_RS25930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AS52_RS25945	COG1428	Deoxynucleoside kinase
AS52_RS25950	COG1428	Deoxynucleoside kinase
AS52_RS25955	COG3858	chitin binding
AS52_RS25955	COG1388	LysM domain
AS52_RS25960	COG1335	isochorismatase
AS52_RS25965	COG0590	tRNA wobble adenosine to inosine editing
AS52_RS25970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS52_RS25975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AS52_RS25980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS52_RS26200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS52_RS26230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS52_RS26250	COG2244	polysaccharide biosynthetic process
AS52_RS26285	COG2208	phosphoserine phosphatase activity
AS52_RS26365	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AS52_RS26395	COG0464	growth