locus-tag class description G5C61_RS00010 ENOG41082BV acetyltransferase G5C61_RS00015 ENOG4105C01 Dihydroxy-acid dehydratase G5C61_RS00020 ENOG4105E5G Alpha beta hydrolase fold G5C61_RS00025 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase G5C61_RS00040 ENOG4105CM2 brancheD-chain amino acid aminotransferase G5C61_RS00050 ENOG4105F6E Acyl-transferase G5C61_RS00065 ENOG4105VT2 5-hydroxyisourate hydrolase G5C61_RS00070 ENOG4108MK9 spermidine N(1)-acetyltransferase G5C61_RS00085 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G5C61_RS00105 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS00115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G5C61_RS00130 ENOG4107R55 ethanolamine transporter G5C61_RS00135 ENOG4107FQ9 ethanolamine ammonia-lyase G5C61_RS00140 ENOG4105CPD ethanolamine ammonia-lyase G5C61_RS00145 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase G5C61_RS00155 ENOG4108IQI permease G5C61_RS00165 ENOG4108Z7F N-acetyltransferase G5C61_RS00190 ENOG4107S9D Alpha beta hydrolase G5C61_RS00200 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G5C61_RS00205 ENOG4105K4P CoA-binding domain protein G5C61_RS00210 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G5C61_RS00215 ENOG4105W8X HesB YadR YfhF-family protein G5C61_RS00230 ENOG41067CD Small, acid-soluble spore protein Tlp G5C61_RS00240 ENOG41075ZD Small, acid-soluble spore protein N G5C61_RS00250 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G5C61_RS00255 ENOG4108I0Z Aconitate hydratase G5C61_RS00260 ENOG410746C Acid-soluble spore protein O G5C61_RS00265 ENOG4107DZX Small, acid-soluble spore protein P G5C61_RS00275 ENOG4105FDF Could be involved in DNA repair (By similarity) G5C61_RS00310 ENOG4105C7W Xanthine dehydrogenase G5C61_RS00320 ENOG4105XRQ Xanthine dehydrogenase accessory factor G5C61_RS00375 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G5C61_RS00390 ENOG4105F27 Major Facilitator G5C61_RS00395 ENOG4105EWC Purine nucleoside phosphorylase G5C61_RS00410 ENOG4107U9T Pfam:Ribonuclease_BN G5C61_RS00430 ENOG4105C6X Major Facilitator G5C61_RS00440 ENOG4105DXB Major Facilitator superfamily G5C61_RS00445 ENOG4107SWG transcriptional regulator MERR family G5C61_RS00455 ENOG4108V2W Carbonate dehydratase G5C61_RS00460 ENOG4105CHH sulfate transporter G5C61_RS00465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS00470 ENOG4105BZU Histidine kinase G5C61_RS00490 ENOG4107QTZ amino acid G5C61_RS00500 ENOG4108ZRV stage ii sporulation protein p G5C61_RS00505 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G5C61_RS00515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G5C61_RS00520 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G5C61_RS00525 ENOG4108P62 biosynthesis protein (CbiG) G5C61_RS00530 ENOG4105CIA precorrin-4 C(11)-methyltransferase G5C61_RS00540 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase G5C61_RS00545 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) G5C61_RS00550 ENOG41081F0 Precorrin-8x methylmutase G5C61_RS00555 ENOG4108JTQ reductase G5C61_RS00560 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G5C61_RS00565 ENOG4105E4R Precorrin-3B C17-methyltransferase G5C61_RS00580 ENOG4105DER m42 family G5C61_RS00630 ENOG4107TT2 Auxin Efflux Carrier G5C61_RS00635 ENOG4105C6K Malic enzyme G5C61_RS00650 ENOG41069ZX G5C61_RS00655 ENOG41069ZX G5C61_RS00660 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G5C61_RS00665 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G5C61_RS00670 ENOG4106P55 Transcriptional regulator G5C61_RS00675 ENOG4107TT2 Auxin Efflux Carrier G5C61_RS00695 ENOG4105DEN Luciferase family G5C61_RS00700 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G5C61_RS00705 ENOG4105CQB FAD linked oxidase domain protein G5C61_RS00715 ENOG4107R7Y intracellular protease Pfpi family G5C61_RS00730 ENOG4105CY2 Citrate transporter G5C61_RS00735 ENOG4105C0A alcohol dehydrogenase G5C61_RS00750 ENOG4105CJ1 ABC, transporter G5C61_RS00760 ENOG4105WH1 Two component transcriptional regulator luxr family G5C61_RS00765 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G5C61_RS00795 ENOG4105DEN Luciferase family G5C61_RS00805 ENOG4107T5V SNARE associated Golgi G5C61_RS00810 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G5C61_RS00815 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G5C61_RS00835 ENOG4105CUB amino acid G5C61_RS00955 ENOG4105UQX Mate efflux family protein G5C61_RS00960 ENOG4105CW7 secretion protein, HlyD family G5C61_RS00970 ENOG4105FS7 Transcriptional regulator G5C61_RS00975 ENOG4105CGK Exodeoxyribonuclease III G5C61_RS00990 ENOG41090KN UPF0303 protein G5C61_RS00995 ENOG4105D9R oxidoreductase G5C61_RS01000 ENOG4105E98 transcriptional regulator DeoR family G5C61_RS01010 ENOG4108TTB tellurium resistance protein G5C61_RS01015 ENOG4106FN3 tellurium resistance protein G5C61_RS01020 ENOG4106FN3 tellurium resistance protein G5C61_RS01025 ENOG4108N0M stress protein G5C61_RS01030 ENOG4105CGH 5'-nucleotidase G5C61_RS01045 ENOG4108TU7 Inherit from COG: (ABC) transporter G5C61_RS01050 ENOG4105CJ1 ABC, transporter G5C61_RS01060 ENOG4106KE4 Dehydrogenase G5C61_RS01065 ENOG4105VEQ Cold shock protein G5C61_RS01070 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS01080 ENOG4105VEQ Cold shock protein G5C61_RS01120 ENOG4105CYC Transferase G5C61_RS01125 ENOG4105DY9 regulatoR G5C61_RS01130 ENOG4105H67 Protein of unknown function (DUF421) G5C61_RS01135 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS01140 ENOG41069ER domain protein G5C61_RS01145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G5C61_RS01175 ENOG4105EC3 peptidase S51, dipeptidase E G5C61_RS01230 ENOG4105DWT malate dehydrogenase (quinone) G5C61_RS01245 ENOG4107EV6 Inherit from COG: YD repeat protein G5C61_RS01300 ENOG4108UB7 G5C61_RS01325 ENOG4105BZW Glycerate kinase G5C61_RS01330 ENOG4107QQ0 gntp family G5C61_RS01335 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR G5C61_RS01340 ENOG4108JUB Transcriptional regulator G5C61_RS01350 ENOG4105C0A alcohol dehydrogenase G5C61_RS01355 ENOG4105KAF membrAne G5C61_RS01375 ENOG4105CUB amino acid G5C61_RS01380 ENOG4105F1J Homogentisate 1,2-dioxygenase G5C61_RS01385 ENOG4105CIH Imidazole acetol-phosphate transaminase G5C61_RS01400 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase G5C61_RS01430 ENOG4105RHY Pfam:UPF0157 G5C61_RS01435 ENOG4108NIW Leucine export protein LeuE G5C61_RS01470 ENOG4105DQ6 Transposase G5C61_RS01485 ENOG4105QIV RNA polymerase G5C61_RS01500 ENOG41083I7 UPF0145 protein G5C61_RS01575 ENOG4105E1K spore germination protein G5C61_RS01585 ENOG4108UQV Membrane G5C61_RS01590 ENOG4108Z5V transcriptional regulator, merr family G5C61_RS01595 ENOG4107EPV Aminotransferase class V G5C61_RS01600 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G5C61_RS01615 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase G5C61_RS01625 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) G5C61_RS01635 ENOG4105D52 delta-aminolevulinic acid dehydratase G5C61_RS01645 ENOG4105N80 Ferric uptake regulator, Fur family G5C61_RS01665 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G5C61_RS01680 ENOG4105CKI cobalamin synthesis protein G5C61_RS01690 ENOG4105DIK (ABC) transporter G5C61_RS01695 ENOG4105DSE periplasmic solute binding protein G5C61_RS01700 ENOG4108PJD permease G5C61_RS01710 ENOG4105CKI cobalamin synthesis protein G5C61_RS01720 ENOG4108S9F abc transporter, atp-binding protein G5C61_RS01725 ENOG4108RZA ABC transporter G5C61_RS01730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS01735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS01740 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G5C61_RS01770 ENOG4105SX7 Transporter G5C61_RS01805 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS01810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS01815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS01820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G5C61_RS01825 ENOG4108J59 Extracellular solute-binding protein, family 5 G5C61_RS01830 ENOG4105C3M thioredoxin reductase G5C61_RS01850 ENOG4105KAF membrAne G5C61_RS01855 ENOG4105KAF membrAne G5C61_RS01870 ENOG4105IW1 AmiS UreI transporter G5C61_RS01875 ENOG4105D9N nucleoside G5C61_RS01885 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G5C61_RS01900 ENOG4107RHR regulatoR G5C61_RS01930 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G5C61_RS01935 ENOG4105D0M Protease HtpX homolog G5C61_RS01940 ENOG41069FQ Metallo-beta-lactamase superfamily G5C61_RS01945 ENOG4105KK4 UPF0060 membrane protein G5C61_RS01955 ENOG4107FKK extracellular solute-binding protein family 1 G5C61_RS01975 ENOG4105CRW Short chain fatty acid transporter G5C61_RS02000 ENOG4105CUC YeeE YedE family protein G5C61_RS02015 ENOG4107QW4 alcohol dehydrogenase G5C61_RS02020 ENOG4107V2S Transcriptional regulator G5C61_RS02035 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G5C61_RS02070 ENOG4105CHR reductase G5C61_RS02075 ENOG4105CPQ Dehydrogenase G5C61_RS02100 ENOG4107SUZ Sodium/hydrogen exchanger family G5C61_RS02105 ENOG4105C37 (CBS) domain G5C61_RS02130 ENOG4108JQ7 (ABC) transporter G5C61_RS02140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS02145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS02150 ENOG4107RRN ABC transporter substrate-binding protein G5C61_RS02160 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) G5C61_RS02175 ENOG4107Y9E nuclease G5C61_RS02185 ENOG4105DWT malate dehydrogenase (quinone) G5C61_RS02190 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G5C61_RS02195 ENOG4105J7I hydrolase G5C61_RS02210 ENOG4105D8X mechanosensitive ion channel G5C61_RS02255 ENOG4107HP6 Transcriptional regulator G5C61_RS02265 ENOG4105C82 Malate synthase G5C61_RS02270 ENOG4105CQB FAD linked oxidase domain protein G5C61_RS02275 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G5C61_RS02280 ENOG4105CQB FAD linked oxidase domain protein G5C61_RS02285 ENOG4105DAA L-lactate G5C61_RS02310 ENOG4105DA5 (ABC) transporter G5C61_RS02315 ENOG41069JR G5C61_RS02355 ENOG4107I77 yiaA/B two helix domain G5C61_RS02370 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G5C61_RS02380 ENOG4105D7N magnesium and cobalt transport protein CorA G5C61_RS02385 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G5C61_RS02395 ENOG4105H67 Protein of unknown function (DUF421) G5C61_RS02400 ENOG4108VXD carboxy-peptidase G5C61_RS02410 ENOG4105BZU Histidine kinase G5C61_RS02415 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G5C61_RS02435 ENOG4105C7S Dehydrogenase G5C61_RS02440 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G5C61_RS02455 ENOG4108X3M OsmC Ohr family protein G5C61_RS02465 ENOG4105DHF Membrane G5C61_RS02510 ENOG4105BZU Histidine kinase G5C61_RS02515 ENOG4105CFC Transporter G5C61_RS02535 ENOG4105D74 hydrolase G5C61_RS02550 ENOG4105RHY Pfam:UPF0157 G5C61_RS02555 ENOG4105FDT acyl-CoA dehydrogenase G5C61_RS02595 ENOG4108IPW abc transporter atp-binding protein G5C61_RS02600 ENOG4105EHG Permease protein G5C61_RS02605 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G5C61_RS02615 ENOG4107QTZ amino acid G5C61_RS02625 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G5C61_RS02635 ENOG41080HJ 6-phospho 3-hexuloisomerase G5C61_RS02655 ENOG4105DJB Major Facilitator Superfamily G5C61_RS02660 ENOG4105D7K pfkb domain protein G5C61_RS02675 ENOG4105EWK phytoene G5C61_RS02735 ENOG4108YZ9 Urea amidohydrolase subunit gamma G5C61_RS02740 ENOG4108I0Q anthranilate phosphoribosyltransferase G5C61_RS02750 ENOG41069ER domain protein G5C61_RS02755 ENOG4108DBC nitroreductase G5C61_RS02765 ENOG4107ZTW SNARE associated Golgi G5C61_RS02775 ENOG4105FBA Phospholipase Carboxylesterase G5C61_RS02780 ENOG4105BZ4 penicillin-binding protein G5C61_RS02790 ENOG4105T38 integral membrane protein G5C61_RS02815 ENOG4105BZ1 (ABC) transporter G5C61_RS02840 ENOG4105K7W phage-related replication protein G5C61_RS02855 ENOG4108RMU ferritin dps family protein G5C61_RS02870 ENOG4105C37 (CBS) domain G5C61_RS02885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G5C61_RS02915 ENOG4105EVN Prephenate dehydrogenase G5C61_RS02925 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G5C61_RS02935 ENOG4105FGV Chromate G5C61_RS02940 ENOG4105CAH Chromate G5C61_RS02945 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G5C61_RS02950 ENOG4105C5R Aminotransferase G5C61_RS02960 ENOG4105G9B Transcriptional regulator G5C61_RS02985 ENOG4105C8J )-transporter G5C61_RS03030 ENOG410635A Membrane G5C61_RS03035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G5C61_RS03040 ENOG4105C3F Signal peptidase i G5C61_RS03095 ENOG4105YVS arsR family transcriptional regulator G5C61_RS03105 ENOG4108DBC nitroreductase G5C61_RS03120 ENOG4105RHY Pfam:UPF0157 G5C61_RS03125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G5C61_RS03130 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G5C61_RS03145 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G5C61_RS03160 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G5C61_RS03165 ENOG4108JYZ YitT family G5C61_RS03185 ENOG4107AYK membrAne G5C61_RS03190 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) G5C61_RS03200 ENOG4105BZN citrate synthase G5C61_RS03205 ENOG4105CMU LysR family (Transcriptional regulator G5C61_RS03210 ENOG4105FDR Membrane G5C61_RS03240 ENOG4105BZU Histidine kinase G5C61_RS03280 ENOG4107BMA Transglycosylase associated protein G5C61_RS03295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G5C61_RS03310 ENOG4108IJ0 Aspartate ammonia-lyase G5C61_RS03315 ENOG4105HDK L-asparaginase G5C61_RS03320 ENOG4108IMY Transcriptional regulator G5C61_RS03335 ENOG4105CT4 transporter G5C61_RS03340 ENOG4105WAB arsR family transcriptional regulator G5C61_RS03360 ENOG4107QTZ amino acid G5C61_RS03365 ENOG4108Z40 Transcriptional regulator G5C61_RS03385 ENOG4105C6K Malic enzyme G5C61_RS03390 ENOG4108AQF aminoglycoside N(3)-acetyltransferase G5C61_RS03400 ENOG41068WN G5C61_RS03410 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G5C61_RS03415 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G5C61_RS03430 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS03435 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS03440 ENOG4107TXC Transcriptional regulator G5C61_RS03445 ENOG4108MK9 spermidine N(1)-acetyltransferase G5C61_RS03495 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G5C61_RS03520 ENOG4105VCH membrane G5C61_RS03530 ENOG4105CI2 imidazolone-5-propionate hydrolase G5C61_RS03540 ENOG4108KGH TRANSCRIPTIONal G5C61_RS03545 ENOG41068WN G5C61_RS03565 ENOG41060D1 Quinol oxidase G5C61_RS03575 ENOG4105BZ9 Cytochrome C oxidase, subunit I G5C61_RS03620 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase G5C61_RS03640 ENOG410829K Lysine exporter protein (Lyse ygga) G5C61_RS03645 ENOG4107QTZ amino acid G5C61_RS03670 ENOG41087NI Sulfite exporter TauE/SafE G5C61_RS03690 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G5C61_RS03710 ENOG4108JYZ YitT family G5C61_RS03730 ENOG4108R9S DSBA oxidoreductase G5C61_RS03735 ENOG4105D0M Protease HtpX homolog G5C61_RS03775 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G5C61_RS03785 ENOG4105Y7M Transcriptional regulator, TetR family G5C61_RS03790 ENOG410814C multidrug resistance protein G5C61_RS03795 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G5C61_RS03800 ENOG4105VEQ Cold shock protein G5C61_RS03805 ENOG4108QY0 Membrane G5C61_RS03820 ENOG4108RYK Nad-dependent epimerase dehydratase G5C61_RS03850 ENOG4105WEF catalase G5C61_RS03860 ENOG4108IPW abc transporter atp-binding protein G5C61_RS03865 ENOG4105CM4 permease protein G5C61_RS03870 ENOG4105DHS permease protein G5C61_RS03875 ENOG4105F0V Cell wall hydrolase G5C61_RS03905 ENOG4105CPQ Dehydrogenase G5C61_RS03910 ENOG4105DT3 PTS system, galactitol-specific IIc component G5C61_RS03915 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) G5C61_RS03930 ENOG4105NF4 modulator of drug activity G5C61_RS03935 ENOG4105C3F Signal peptidase i G5C61_RS03955 ENOG4105C98 muts2 protein G5C61_RS03965 ENOG4108UMN azlc family G5C61_RS03970 ENOG4108JCI Transcriptional regulator G5C61_RS03975 ENOG4108ZCF integral membrane protein G5C61_RS03985 ENOG41062ES Transcriptional regulator G5C61_RS04000 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G5C61_RS04025 ENOG4107ETC gas vesicle protein G5C61_RS04030 ENOG4108XNA Gas vesicle G5C61_RS04035 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G5C61_RS04045 ENOG4105NAE bifunctional deaminase-reductase domain protein G5C61_RS04055 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G5C61_RS04060 ENOG41067SE Tetr family transcriptional regulator G5C61_RS04070 ENOG4105WEF catalase G5C61_RS04090 ENOG4105N14 lysine exporter protein LysE YggA G5C61_RS04095 ENOG4106AXJ AraC family transcriptional regulator G5C61_RS04100 ENOG4108XG2 Histidine kinase G5C61_RS04155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G5C61_RS04170 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily G5C61_RS04185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G5C61_RS04190 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) G5C61_RS04195 ENOG4105BZU Histidine kinase G5C61_RS04220 ENOG4105BZU Histidine kinase G5C61_RS04225 ENOG4105D9U N-acetyltransferase G5C61_RS04250 ENOG4107QM2 Aldo Keto reductase G5C61_RS04260 ENOG4108UZ3 Transporter G5C61_RS04265 ENOG4108MCI Transcriptional regulator, ARAC family G5C61_RS04280 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G5C61_RS04290 ENOG4107ETC gas vesicle protein G5C61_RS04320 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G5C61_RS04335 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G5C61_RS04340 ENOG4107KM7 Heat induced stress protein YflT G5C61_RS04350 ENOG4105EGI Transcriptional regulator G5C61_RS04355 ENOG41081I9 integral membrane protein G5C61_RS04365 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G5C61_RS04395 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G5C61_RS04400 ENOG4105F6J Alpha beta hydrolase fold G5C61_RS04410 ENOG4108IYU L-aspartate oxidase G5C61_RS04415 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G5C61_RS04420 ENOG4106FTQ Taurine ABC transporter, periplasmic G5C61_RS04425 ENOG4108IY8 ABC, transporter G5C61_RS04435 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS04460 ENOG4105FBW Monooxygenase G5C61_RS04465 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS04475 ENOG4105CJZ response regulator G5C61_RS04480 ENOG4105EWM Histidine kinase G5C61_RS04485 ENOG4105C19 ABC transporter G5C61_RS04505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS04515 ENOG41087NI Sulfite exporter TauE/SafE G5C61_RS04520 ENOG4105VFE sira family G5C61_RS04525 ENOG4107TPS domain protein G5C61_RS04530 ENOG4105VFE sira family G5C61_RS04545 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase G5C61_RS04550 ENOG4105VFE sira family G5C61_RS04555 ENOG4105XTG Pfam:DUF156 G5C61_RS04575 ENOG4105GZI Transcriptional regulator G5C61_RS04595 ENOG4108S3Y transcriptional regulator G5C61_RS04605 ENOG4105CS2 ec 3.2.1.21 G5C61_RS04620 ENOG4105X3H Excalibur domain protein G5C61_RS04635 ENOG4105N14 lysine exporter protein LysE YggA G5C61_RS04650 ENOG4107RSM transcriptional regulator G5C61_RS04670 ENOG4105BZU Histidine kinase G5C61_RS04675 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein G5C61_RS04690 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G5C61_RS04695 ENOG4108TVJ Nitroreductase G5C61_RS04700 ENOG4105C26 Dehydrogenase G5C61_RS04720 ENOG4108V0P LemA family G5C61_RS04730 ENOG4105KVH Transcriptional regulator G5C61_RS04735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G5C61_RS04740 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G5C61_RS04745 ENOG41068WN G5C61_RS04795 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G5C61_RS04810 ENOG4108W15 Protein of unknown function (DUF1456) G5C61_RS04820 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 G5C61_RS04830 ENOG4105VEQ Cold shock protein G5C61_RS04840 ENOG4105VEQ Cold shock protein G5C61_RS04845 ENOG4105CSH Transporter G5C61_RS04850 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G5C61_RS04860 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS04900 ENOG4105CHH sulfate transporter G5C61_RS04910 ENOG4105CT4 transporter G5C61_RS04920 ENOG4105C8M UPF0272 protein G5C61_RS04925 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase G5C61_RS04935 ENOG4105DMW Dehydrogenase reductase G5C61_RS04945 ENOG4105D2H Uronic isomerase G5C61_RS04980 ENOG4105KAC Antibiotic biosynthesis monooxygenase G5C61_RS05000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS05015 ENOG4105CJ1 ABC, transporter G5C61_RS05030 ENOG4105VMP Transcriptional regulator G5C61_RS05040 ENOG4105EGI Transcriptional regulator G5C61_RS05060 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS05065 ENOG4105F0H myo-inositol catabolism protein G5C61_RS05070 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G5C61_RS05090 ENOG4105DH8 myo-inositol catabolism G5C61_RS05095 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G5C61_RS05115 ENOG4105D2N Aldolase G5C61_RS05120 ENOG4107VG4 Xylose isomerase domain protein TIM barrel G5C61_RS05125 ENOG4107QNK )-transporter G5C61_RS05130 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G5C61_RS05140 ENOG4105DQ4 alcohol dehydrogenase G5C61_RS05145 ENOG4105VUF Transcriptional regulator G5C61_RS05160 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein G5C61_RS05185 ENOG4105VEQ Cold shock protein G5C61_RS05190 ENOG4105C8Q Methyl-accepting chemotaxis G5C61_RS05195 ENOG4108VXD carboxy-peptidase G5C61_RS05200 ENOG4107QKS N-acylglucosamine 2-epimerase G5C61_RS05220 ENOG4106SCS STAS domain G5C61_RS05230 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G5C61_RS05245 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G5C61_RS05260 ENOG4105F1N DNA alkylation repair G5C61_RS05315 ENOG4105XPP Protein of unknown function (DUF1275) G5C61_RS05325 ENOG4105E98 transcriptional regulator DeoR family G5C61_RS05330 ENOG410667J hydrolase G5C61_RS05340 ENOG4105C5I Dehydrogenase G5C61_RS05390 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G5C61_RS05400 ENOG4107QNK )-transporter G5C61_RS05405 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) G5C61_RS05415 ENOG4105CMG Carbohydrate kinase G5C61_RS05420 ENOG4105CMD Transcriptional regulator, GntR family G5C61_RS05425 ENOG4107TVP HD domain protein G5C61_RS05440 ENOG4105CE1 Ferrous iron transport protein b G5C61_RS05445 ENOG4105CE1 Ferrous iron transport protein b G5C61_RS05450 ENOG4105CE1 Ferrous iron transport protein b G5C61_RS05465 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G5C61_RS05520 ENOG4108RPX mosc domain containing protein G5C61_RS05525 ENOG4105D9N nucleoside G5C61_RS05560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G5C61_RS05580 ENOG41069DP small acid-soluble spore protein G5C61_RS05595 ENOG4105XEA Tetr family transcriptional regulator G5C61_RS05600 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) G5C61_RS05605 ENOG4105C85 amino acid G5C61_RS05610 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G5C61_RS05615 ENOG4106IPI cyclase, family G5C61_RS05620 ENOG41069HH 4-oxalocrotonate tautomerase G5C61_RS05650 ENOG4105KME endoribonuclease L-psp G5C61_RS05665 ENOG4107V0Z fmn reductase G5C61_RS05670 ENOG4105U1N riboflavin G5C61_RS05675 ENOG4105EFA 4-hydroxyphenylacetate G5C61_RS05730 ENOG4108ZMX Domain of unknown function (DU1801) G5C61_RS05740 ENOG4105D7V transposase G5C61_RS05780 ENOG4107SCJ type I restriction enzyme EcoKI subunit R G5C61_RS05785 ENOG4105M6F mutator MutT protein G5C61_RS05810 ENOG4105DJ2 Major Facilitator Superfamily G5C61_RS05815 ENOG4105GZI Transcriptional regulator G5C61_RS05865 ENOG4105DJB Major Facilitator Superfamily G5C61_RS05870 ENOG4105CXK mandelate racemase muconate lactonizing G5C61_RS05880 ENOG4105D7K pfkb domain protein G5C61_RS05885 ENOG4105J4Q Transcriptional regulator G5C61_RS05905 ENOG4105CI1 PTS System G5C61_RS05910 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) G5C61_RS05920 ENOG4105CKI cobalamin synthesis protein G5C61_RS05925 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G5C61_RS05930 ENOG4105DHP deoxycytidine triphosphate deaminase G5C61_RS05935 ENOG4105DIK (ABC) transporter G5C61_RS05940 ENOG4105DSE periplasmic solute binding protein G5C61_RS05945 ENOG4105CKI cobalamin synthesis protein G5C61_RS05965 ENOG4105MDS 4-oxalocrotonate tautomerase G5C61_RS05970 ENOG4107V2S Transcriptional regulator G5C61_RS06015 ENOG4105CHJ isochorismatase hydrolase G5C61_RS06025 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase G5C61_RS06030 ENOG4108VGI doxx family G5C61_RS06045 ENOG4105C94 Transporter G5C61_RS06065 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G5C61_RS06070 ENOG4105KNY Microcompartments protein G5C61_RS06075 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml G5C61_RS06090 ENOG4105KNY Microcompartments protein G5C61_RS06095 ENOG4105C0A alcohol dehydrogenase G5C61_RS06100 ENOG4106D67 ethanolamine utilization protein G5C61_RS06105 ENOG4107FQ9 ethanolamine ammonia-lyase G5C61_RS06110 ENOG4105CPD ethanolamine ammonia-lyase G5C61_RS06115 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase G5C61_RS06120 ENOG4106S4J ethanolamine utilization protein EutP G5C61_RS06125 ENOG4105M3W utilization protein G5C61_RS06130 ENOG4105ENY Ethanolamine utilization protein eutH G5C61_RS06160 ENOG4105KBX Transcriptional regulator, TetR family G5C61_RS06165 ENOG4105KPY Small multidrug resistance protein G5C61_RS06170 ENOG4105RXJ G5C61_RS06180 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS06195 ENOG4105ST3 Transcriptional regulator G5C61_RS06215 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G5C61_RS06220 ENOG4105DWV Homoserine O-trans-acetylase G5C61_RS06230 ENOG4108NGU Transcriptional regulator G5C61_RS06245 ENOG4105CT4 transporter G5C61_RS06250 ENOG4105CPQ Dehydrogenase G5C61_RS06255 ENOG4105PGZ NB-ARC domain G5C61_RS06285 ENOG4107FCW Abortive infection protein G5C61_RS06300 ENOG4108JYZ YitT family G5C61_RS06315 ENOG4107RB3 L-asparaginase G5C61_RS06335 ENOG4105K7K Transcriptional regulator G5C61_RS06345 ENOG4108W5M transcriptional regulator G5C61_RS06355 ENOG4105F27 Major Facilitator G5C61_RS06360 ENOG4105WDR G5C61_RS06365 ENOG4107KM7 Heat induced stress protein YflT G5C61_RS06375 ENOG4105C6K Malic enzyme G5C61_RS06430 ENOG4105YWU small acid-soluble spore protein G5C61_RS06440 ENOG4107R3K hydrolase G5C61_RS06455 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G5C61_RS06460 ENOG4105E1K spore germination protein G5C61_RS06465 ENOG4108Q5U germination protein, ger(x)c family G5C61_RS06495 ENOG4105YWU small acid-soluble spore protein G5C61_RS06540 ENOG4105CVM Molybdenum cofactor synthesis domain protein G5C61_RS06550 ENOG4108RIR Molybdenum cofactor biosynthesis protein G5C61_RS06580 ENOG4105C7F AcnD-accessory protein PrpF G5C61_RS06585 ENOG4108KAM Transcriptional regulator G5C61_RS06610 ENOG4106I4J membrane G5C61_RS06615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G5C61_RS06630 ENOG4105K4H Nlp p60 protein G5C61_RS06635 ENOG4105CZM Major Facilitator G5C61_RS06640 ENOG4107MII Sugar-specific transcriptional regulator TrmB G5C61_RS06650 ENOG4105QIV RNA polymerase G5C61_RS06660 ENOG4105VEQ Cold shock protein G5C61_RS06685 ENOG4105C85 amino acid G5C61_RS06690 ENOG4105C26 Dehydrogenase G5C61_RS06700 ENOG4108XI2 Domain of unknown function (DUF1963) G5C61_RS06720 ENOG4108ZRV stage ii sporulation protein p G5C61_RS06760 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) G5C61_RS06800 ENOG4105WCN acetyltransferase G5C61_RS06820 ENOG4105VUF Transcriptional regulator G5C61_RS06825 ENOG4105CPC Aldo Keto reductase G5C61_RS06835 ENOG4107SWG transcriptional regulator MERR family G5C61_RS06860 ENOG4108HKT sucrose-6-phosphate hydrolase G5C61_RS06900 ENOG4105C19 ABC transporter G5C61_RS06910 ENOG4105EWM Histidine kinase G5C61_RS06915 ENOG4105CJZ response regulator G5C61_RS06925 ENOG4105ME7 Membrane G5C61_RS06930 ENOG4105XTG Pfam:DUF156 G5C61_RS06935 ENOG4105WFK nuclease G5C61_RS06945 ENOG4105EEM helicase G5C61_RS06950 ENOG4105E39 Enoyl-CoA hydratase G5C61_RS06955 ENOG4105KVH Transcriptional regulator G5C61_RS06970 ENOG4106A3M Cytochrome p-450 G5C61_RS06980 ENOG4105CKK Glycosyl transferase, family 2 G5C61_RS06985 ENOG4107QQG Dehydrogenase G5C61_RS06990 ENOG4105CKK Glycosyl transferase, family 2 G5C61_RS07010 ENOG4106YBV Methyl-accepting chemotaxis G5C61_RS07025 ENOG4105JVQ RNA Polymerase G5C61_RS07030 ENOG4108ZJ4 polysaccharide deacetylase G5C61_RS07045 ENOG4108IQI permease G5C61_RS07055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G5C61_RS07075 ENOG4105CZN Potassium uptake protein G5C61_RS07080 ENOG4107ZYR domain protein G5C61_RS07100 ENOG4105C0H protease G5C61_RS07110 ENOG4105F3H Histidine kinase G5C61_RS07120 ENOG4108S4H thioesterase Superfamily protein G5C61_RS07125 ENOG4105DRR Transcriptional regulator, GntR family G5C61_RS07135 ENOG41064HX Suppressor of fused protein (SUFU) G5C61_RS07140 ENOG4105DC7 peptidase M24 G5C61_RS07150 ENOG4108RCF TRANSCRIPTIONal G5C61_RS07160 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G5C61_RS07175 ENOG4105E90 ABC transporter G5C61_RS07180 ENOG4108IJ8 ABC transporter G5C61_RS07195 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS07205 ENOG4108HGU Histidine kinase G5C61_RS07210 ENOG4107TSN permease G5C61_RS07215 ENOG4105CK2 sodium dicarboxylate symporter G5C61_RS07225 ENOG4105EA8 2-Nitropropane dioxygenase G5C61_RS07230 ENOG4105CH6 catalase G5C61_RS07245 ENOG4108RCF TRANSCRIPTIONal G5C61_RS07250 ENOG4105E0M Sulfatase G5C61_RS07265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G5C61_RS07285 ENOG4105JHY Membrane G5C61_RS07290 ENOG4105J7D transcriptional regulator G5C61_RS07300 ENOG4107RSM transcriptional regulator G5C61_RS07315 ENOG4108RYK Nad-dependent epimerase dehydratase G5C61_RS07325 ENOG4105KT7 mgtC SapB transporter G5C61_RS07330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G5C61_RS07335 ENOG4105K7W phage-related replication protein G5C61_RS07345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS07360 ENOG4105C85 amino acid G5C61_RS07410 ENOG4105C1Q protoporphyrinogen oxidase G5C61_RS07415 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase G5C61_RS07420 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) G5C61_RS07435 ENOG4108NIW Leucine export protein LeuE G5C61_RS07455 ENOG4105D64 Mechanosensitive ion channel G5C61_RS07460 ENOG4105K4I Scp-like extracellular G5C61_RS07465 ENOG4105C37 (CBS) domain G5C61_RS07475 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G5C61_RS07480 ENOG4107YZX Universal stress protein G5C61_RS07490 ENOG4105CTQ phosphohexokinase G5C61_RS07500 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C G5C61_RS07505 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G5C61_RS07520 ENOG4108NHD germination protein G5C61_RS07540 ENOG4105DVE abc transporter atp-binding protein G5C61_RS07555 ENOG4108JYZ YitT family G5C61_RS07570 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G5C61_RS07600 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G5C61_RS07610 ENOG4105C5Y PTS System G5C61_RS07625 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G5C61_RS07645 ENOG4105CHH sulfate transporter G5C61_RS07650 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G5C61_RS07660 ENOG4106Z5R G5C61_RS07665 ENOG410841Q phosphoesterase PA-phosphatase related protein G5C61_RS07670 ENOG4108N23 SpoOM-related protein G5C61_RS07675 ENOG4105D9P serine threonine protein kinase G5C61_RS07700 ENOG4105VSD UPF0346 protein G5C61_RS07705 ENOG4108TGC Acyltransferase G5C61_RS07710 ENOG4105F0I Aminotransferase G5C61_RS07720 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G5C61_RS07725 ENOG4108TSC N-acetyltransferase G5C61_RS07730 ENOG4107S4Y M20 DapE family protein YgeY G5C61_RS07745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G5C61_RS07760 ENOG4105BZU Histidine kinase G5C61_RS07790 ENOG41090WU lipolytic protein G-D-S-L family G5C61_RS07795 ENOG4108KF3 Electron transport protein SCO1 SenC G5C61_RS07805 ENOG4108RCR degv family G5C61_RS07815 ENOG4105C7B Threonine dehydratase G5C61_RS07825 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G5C61_RS07830 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G5C61_RS07835 ENOG4105CIY formyltetrahydrofolate deformylase G5C61_RS07840 ENOG4105CMG Carbohydrate kinase G5C61_RS07870 ENOG4105DY8 decarboxylase G5C61_RS07890 ENOG4105CVP deoxyribo-dipyrimidine photolyase G5C61_RS07895 ENOG4105BZU Histidine kinase G5C61_RS07920 ENOG4105C26 Dehydrogenase G5C61_RS07930 ENOG4108JPW Aminotransferase G5C61_RS07945 ENOG4108U5N UPF0316 protein G5C61_RS07950 ENOG4107QIV Cytochrome c biogenesis protein G5C61_RS07960 ENOG4105BZ1 (ABC) transporter G5C61_RS07965 ENOG4105BZ1 (ABC) transporter G5C61_RS07970 ENOG4105VXM UPF0154 protein G5C61_RS07985 ENOG4105VPS UPF0291 protein G5C61_RS07990 ENOG4108SVB resolvase G5C61_RS08000 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G5C61_RS08010 ENOG41076HS cation diffusion facilitator family transporter G5C61_RS08015 ENOG4105C0X amino acid G5C61_RS08025 ENOG4105C5F glutamine synthetase G5C61_RS08030 ENOG4105KV4 Transcriptional regulator G5C61_RS08035 ENOG4105CXI aluminum resistance protein G5C61_RS08040 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G5C61_RS08045 ENOG4105EN6 Membrane G5C61_RS08050 ENOG4106F1P AAA ATPase, central domain protein G5C61_RS08060 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G5C61_RS08065 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G5C61_RS08070 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G5C61_RS08075 ENOG4105CUB amino acid G5C61_RS08090 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G5C61_RS08095 ENOG4105DQU oxidoreductase, subunit beta G5C61_RS08100 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G5C61_RS08115 ENOG4105MCT stage V sporulation protein S G5C61_RS08120 ENOG4105D48 metallophosphoesterase G5C61_RS08130 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G5C61_RS08135 ENOG4105CEV competence damage-inducible protein G5C61_RS08140 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G5C61_RS08155 ENOG4105XZV Protein of unknown function (DUF3243) G5C61_RS08160 ENOG4108RKS Short-chain dehydrogenase reductase Sdr G5C61_RS08180 ENOG4105UIB (ABC) transporter G5C61_RS08185 ENOG4108JQ9 ABC transporter G5C61_RS08190 ENOG4105DIH basic membrane G5C61_RS08195 ENOG4105FDP GntR family transcriptional regulator G5C61_RS08200 ENOG4105CNU cell division protein FtsK G5C61_RS08210 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit G5C61_RS08220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G5C61_RS08230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G5C61_RS08235 ENOG4108S0H Dipicolinic acid synthetase, b subunit G5C61_RS08240 ENOG4105E35 Dipicolinate synthase subunit A G5C61_RS08250 ENOG4105C1V Peptidase, M16 G5C61_RS08260 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G5C61_RS08265 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G5C61_RS08270 ENOG4105DTN riboflavin biosynthesis protein ribF G5C61_RS08285 ENOG4105W7A Protein of unknown function (DUF503) G5C61_RS08290 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G5C61_RS08295 ENOG4105VHM ribosomal protein G5C61_RS08300 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination G5C61_RS08305 ENOG4105CHV Transcription elongation factor NusA G5C61_RS08310 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G5C61_RS08315 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) G5C61_RS08320 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G5C61_RS08325 ENOG4105DZP Membrane-associated zinc metalloprotease G5C61_RS08330 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G5C61_RS08335 ENOG4105KNE Phosphatidate cytidylyltransferase G5C61_RS08340 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G5C61_RS08345 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G5C61_RS08350 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G5C61_RS08355 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G5C61_RS08360 ENOG4105CE9 30S ribosomal protein S2 G5C61_RS08370 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS08375 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) G5C61_RS08380 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis G5C61_RS08385 ENOG4105CBS Chea signal transduction histidine kinase G5C61_RS08390 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G5C61_RS08400 ENOG4105FZW flagellar biosynthesis regulator FlhF G5C61_RS08405 ENOG4105D7B Flagellar biosynthesis protein flha G5C61_RS08410 ENOG4105D00 flagellar biosynthetic protein flhB G5C61_RS08415 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G5C61_RS08420 ENOG4105VS8 Flagellar biosynthetic protein fliq G5C61_RS08425 ENOG4105CN7 Flagellar biosynthetic protein FliP G5C61_RS08435 ENOG4107YTP response regulator receiver protein G5C61_RS08440 ENOG4105DD5 Flagellar motor switch protein G5C61_RS08445 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G5C61_RS08455 ENOG41068WV flagellar FlbD family protein G5C61_RS08460 ENOG4108JQA flagellar G5C61_RS08465 ENOG410822I Flagellar hook capping protein G5C61_RS08480 ENOG4106YF4 Flagellar biosynthesis chaperone G5C61_RS08495 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G5C61_RS08500 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G5C61_RS08505 ENOG4105VQ0 flagellar hook-basal body complex protein fliE G5C61_RS08510 ENOG4108ZC9 flagellar basal-body rod protein flgc G5C61_RS08515 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G5C61_RS08520 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) G5C61_RS08525 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G5C61_RS08530 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G5C61_RS08535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G5C61_RS08545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G5C61_RS08550 ENOG4105C79 DNA protecting protein DprA G5C61_RS08555 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G5C61_RS08560 ENOG4105CMV Succinyl-CoA synthetase subunit beta G5C61_RS08580 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G5C61_RS08590 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G5C61_RS08600 ENOG4105VB6 UPF0109 protein G5C61_RS08605 ENOG4105K5M 30s ribosomal protein S16 G5C61_RS08615 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) G5C61_RS08620 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G5C61_RS08625 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G5C61_RS08640 ENOG4105CHR reductase G5C61_RS08645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G5C61_RS08650 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G5C61_RS08655 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) G5C61_RS08660 ENOG4105CB5 ATP-dependent DNA helicase recG G5C61_RS08665 ENOG4105EJQ L-serine dehydratase G5C61_RS08680 ENOG4105DP4 dak2 domain fusion protein ylov G5C61_RS08685 ENOG4108ZAA Alkaline-shock protein G5C61_RS08690 ENOG4105VB9 50S ribosomal protein l28 G5C61_RS08700 ENOG4105FJ0 thiamine G5C61_RS08705 ENOG4105DJV ribulose-phosphate 3-epimerase G5C61_RS08710 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G5C61_RS08715 ENOG4105D9P serine threonine protein kinase G5C61_RS08720 ENOG4108ZF3 Phosphatase G5C61_RS08725 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G5C61_RS08730 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G5C61_RS08735 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G5C61_RS08745 ENOG4105C25 Primosomal protein n' G5C61_RS08750 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G5C61_RS08760 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G5C61_RS08765 ENOG4105KC4 UPF0296 protein G5C61_RS08770 ENOG4105DSJ YicC domain protein G5C61_RS08785 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G5C61_RS08800 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) G5C61_RS08815 ENOG4105CD3 dihydroorotase G5C61_RS08830 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G5C61_RS08835 ENOG4105C34 Pseudouridine synthase G5C61_RS08840 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G5C61_RS08860 ENOG4105DBK s4 domain protein G5C61_RS08865 ENOG41067XK integral membrane protein G5C61_RS08870 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G5C61_RS08875 ENOG4105DFA alanine racemase domain protein G5C61_RS08880 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G5C61_RS08885 ENOG4105WR5 sporulation protein, YlmC YmxH family G5C61_RS08895 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS08900 ENOG4108AWX Sporulation factor SpoIIGA G5C61_RS08905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G5C61_RS08910 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G5C61_RS08915 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) G5C61_RS08920 ENOG4105D4A Cell wall formation (By similarity) G5C61_RS08925 ENOG4105CNI cell division protein FtsW G5C61_RS08930 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G5C61_RS08935 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G5C61_RS08940 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G5C61_RS08945 ENOG4105CJN penicillin-binding protein G5C61_RS08950 ENOG4105CJN penicillin-binding protein G5C61_RS08955 ENOG41068DC Essential cell division protein (By similarity) G5C61_RS08965 ENOG41074B2 UPF0747 protein G5C61_RS08980 ENOG4107QX3 carboxylase G5C61_RS08985 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G5C61_RS08990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G5C61_RS08995 ENOG4108YG3 N-acetyltransferase G5C61_RS09005 ENOG4105E39 Enoyl-CoA hydratase G5C61_RS09010 ENOG41067VY 50S ribosomal protein L32 G5C61_RS09015 ENOG4105KNH Nucleic acid-binding protein G5C61_RS09020 ENOG4105CDE UPF0348 protein G5C61_RS09025 ENOG41063PX domain protein G5C61_RS09030 ENOG4105D78 K07001 NTE family protein G5C61_RS09035 ENOG4105H20 Sporulation integral membrane protein YlbJ G5C61_RS09040 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G5C61_RS09045 ENOG4106H78 methyltransferase G5C61_RS09055 ENOG4105WUC UPF0298 protein G5C61_RS09090 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit G5C61_RS09095 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G5C61_RS09100 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) G5C61_RS09110 ENOG4108SXZ UPF0302 protein G5C61_RS09115 ENOG41068YB TPR repeat-containing protein G5C61_RS09120 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G5C61_RS09130 ENOG4105CIH Imidazole acetol-phosphate transaminase G5C61_RS09135 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G5C61_RS09145 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G5C61_RS09150 ENOG4105DK0 Indole-3-glycerol phosphate synthase G5C61_RS09155 ENOG4108I0Q anthranilate phosphoribosyltransferase G5C61_RS09165 ENOG4105D49 3-dehydroquinate synthase G5C61_RS09170 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G5C61_RS09175 ENOG4105BZU Histidine kinase G5C61_RS09180 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G5C61_RS09185 ENOG4105EAH synthase G5C61_RS09190 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G5C61_RS09195 ENOG4105XXQ heptaprenyl diphosphate synthase component I G5C61_RS09200 ENOG4105WP2 Tryptophan RNA-binding attenuator protein G5C61_RS09205 ENOG4105EUJ GTP cyclohydrolase i G5C61_RS09210 ENOG4105K70 DNA-binding protein G5C61_RS09215 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) G5C61_RS09230 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G5C61_RS09250 ENOG4105DJB Major Facilitator Superfamily G5C61_RS09255 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G5C61_RS09260 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G5C61_RS09265 ENOG4105E9Q Acyl-transferase G5C61_RS09270 ENOG4105CAT Cytidine monophosphate kinase G5C61_RS09285 ENOG4105MSI germination protein ypeb G5C61_RS09290 ENOG4105F0V Cell wall hydrolase G5C61_RS09300 ENOG4107RB3 L-asparaginase G5C61_RS09305 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase G5C61_RS09315 ENOG4108S6Z Negative regulator of genetic competence G5C61_RS09320 ENOG4108XDN Transcriptional regulator G5C61_RS09325 ENOG4107RGJ metallophosphoesterase G5C61_RS09340 ENOG4105I7S Abortive infection protein G5C61_RS09345 ENOG4105C9U ATP-dependent DNA helicase RecQ G5C61_RS09360 ENOG4108SAX Membrane G5C61_RS09365 ENOG4108JQ1 Dehydrogenase G5C61_RS09370 ENOG4105DR5 peptidase G5C61_RS09375 ENOG4105BZU Histidine kinase G5C61_RS09380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS09385 ENOG4105CRE cytochrome C G5C61_RS09390 ENOG4107TWT Cytochrome c biogenesis protein G5C61_RS09395 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G5C61_RS09400 ENOG4105FE9 pseudouridine synthase G5C61_RS09410 ENOG4108JIC nucleoside recognition domain protein G5C61_RS09415 ENOG4105DZ1 carboxypeptidase G5C61_RS09420 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G5C61_RS09425 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G5C61_RS09445 ENOG4107ZE5 PPIases accelerate the folding of proteins G5C61_RS09450 ENOG4105PTM secreted protein G5C61_RS09465 ENOG4105G6R Stage v sporulation protein ae G5C61_RS09475 ENOG4105CZ3 stage V sporulation protein ad G5C61_RS09480 ENOG41090VF Stage v sporulation protein ac G5C61_RS09495 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS09500 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G5C61_RS09505 ENOG41082AN stage II sporulation protein G5C61_RS09510 ENOG4105DZ1 carboxypeptidase G5C61_RS09525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G5C61_RS09535 ENOG4105I3K Ferric uptake regulator, Fur family G5C61_RS09540 ENOG4105MZ9 stage II sporulation protein m G5C61_RS09545 ENOG4108YZ4 nudix hydrolase G5C61_RS09555 ENOG4105CPC Aldo Keto reductase G5C61_RS09565 ENOG4108IIH CoA-transferase subunit B G5C61_RS09570 ENOG4105D6N CoA-transferase, subunit a G5C61_RS09575 ENOG4105CHU acetyl-coa acetyltransferase G5C61_RS09580 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G5C61_RS09600 ENOG4108IXY short-chain dehydrogenase reductase G5C61_RS09605 ENOG41069FQ Metallo-beta-lactamase superfamily G5C61_RS09610 ENOG4105II7 pyrroline-5-carboxylate reductase G5C61_RS09615 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G5C61_RS09620 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G5C61_RS09625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G5C61_RS09630 ENOG4105C26 Dehydrogenase G5C61_RS09635 ENOG4105G9B Transcriptional regulator G5C61_RS09655 ENOG4107SJI Dehydrogenase G5C61_RS09660 ENOG4105BZ8 glutamate synthase G5C61_RS09665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G5C61_RS09670 ENOG4108HNZ carboxyl transferase G5C61_RS09685 ENOG4108VZI ErfK ybiS ycfS ynhG family protein G5C61_RS09690 ENOG4108QEG Membrane G5C61_RS09695 ENOG4105CDA abc transporter atp-binding protein G5C61_RS09700 ENOG4105E5Q amino acid AbC transporter G5C61_RS09705 ENOG4108HW3 (ABC) transporter G5C61_RS09710 ENOG4108Y6J UPF0403 protein G5C61_RS09715 ENOG4105DJT lAO AO transport system ATPase G5C61_RS09720 ENOG4105D5P Methylmalonyl-coA mutase G5C61_RS09730 ENOG4105C7S Dehydrogenase G5C61_RS09735 ENOG4105CPP Dehydrogenase, E1 component G5C61_RS09755 ENOG4107RDP Dehydrogenase G5C61_RS09765 ENOG4108JUB Transcriptional regulator G5C61_RS09770 ENOG4106CCJ Protein of unknown function (DUF2627) G5C61_RS09775 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G5C61_RS09785 ENOG4105DUX Transporter G5C61_RS09790 ENOG4107QQR Sporulation G5C61_RS09795 ENOG4105S1Z Stage IV sporulation protein B G5C61_RS09800 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G5C61_RS09810 ENOG4105DX0 Hemolysin A G5C61_RS09825 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G5C61_RS09835 ENOG4105M7K Involved in the transcription termination process (By similarity) G5C61_RS09840 ENOG4108ZSR alkaline shock protein G5C61_RS09845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G5C61_RS09865 ENOG410644B Stage III sporulation protein af G5C61_RS09875 ENOG4105KQ4 Stage iii sporulation protein ad G5C61_RS09880 ENOG4108CQH stage III sporulation protein AC G5C61_RS09885 ENOG4105KR5 Stage iii sporulation protein G5C61_RS09890 ENOG4105CD2 stage iii sporulation protein aa G5C61_RS09900 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G5C61_RS09905 ENOG4105DC7 peptidase M24 G5C61_RS09910 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G5C61_RS09920 ENOG4105CBJ Metal-dependent enzyme G5C61_RS09935 ENOG4105KST dependent repressor G5C61_RS09940 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G5C61_RS09955 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) G5C61_RS09960 ENOG4105WZW rhodanese family G5C61_RS09970 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G5C61_RS09975 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G5C61_RS09980 ENOG4105C0D helicase G5C61_RS10015 ENOG4106855 Competence protein G5C61_RS10040 ENOG4105C5X domain protein G5C61_RS10055 ENOG4105DKQ ROK family G5C61_RS10065 ENOG4107ZXI Rhomboid family G5C61_RS10080 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G5C61_RS10085 ENOG410861F 50S ribosomal protein L33 G5C61_RS10105 ENOG4108UTW Plays a role in the regulation of phosphate uptake G5C61_RS10110 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS10115 ENOG4107RF6 penicillin-binding protein G5C61_RS10155 ENOG4105SXS Protein of unknown function (DUF456) G5C61_RS10165 ENOG4107RCC Major Facilitator Superfamily G5C61_RS10175 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G5C61_RS10180 ENOG41063Y9 G5C61_RS10185 ENOG4108U5J '-nucleotidase G5C61_RS10190 ENOG4105N80 Ferric uptake regulator, Fur family G5C61_RS10195 ENOG4105FAV ABC, transporter G5C61_RS10200 ENOG4105FDK ABC transporter G5C61_RS10210 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G5C61_RS10225 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G5C61_RS10230 ENOG4105EGD dinuclear metal center protein, YbgI family G5C61_RS10245 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS10250 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS10255 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G5C61_RS10260 ENOG4107XJU UPF0178 protein G5C61_RS10265 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G5C61_RS10275 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G5C61_RS10285 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G5C61_RS10290 ENOG4105KG3 cytidine deaminase G5C61_RS10295 ENOG4107YR5 Diacylglycerol kinase G5C61_RS10300 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G5C61_RS10305 ENOG4105CTJ Metal Dependent Phosphohydrolase G5C61_RS10310 ENOG4105C9A Phoh family G5C61_RS10320 ENOG41068P3 sporulation protein YqfC G5C61_RS10335 ENOG4105F7J membrane-bound serine protease G5C61_RS10340 ENOG4105KTH gatB Yqey G5C61_RS10350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G5C61_RS10355 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G5C61_RS10360 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G5C61_RS10365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G5C61_RS10375 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G5C61_RS10380 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G5C61_RS10385 ENOG4105CSA Coproporphyrinogen iii oxidase G5C61_RS10390 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G5C61_RS10405 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) G5C61_RS10410 ENOG4105TQK DNA polymerase iii, delta' subunit G5C61_RS10420 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G5C61_RS10425 ENOG4108UK2 deaminase G5C61_RS10430 ENOG4105KQC Competence protein G5C61_RS10440 ENOG4105DXX methyltransferase G5C61_RS10445 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G5C61_RS10450 ENOG4108WF2 Metal Dependent Phosphohydrolase G5C61_RS10455 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G5C61_RS10460 ENOG410812S Rna-binding protein G5C61_RS10465 ENOG4105E2X shikimate dehydrogenase G5C61_RS10470 ENOG4105CQW ribosome biogenesis GTPase YqeH G5C61_RS10475 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase G5C61_RS10485 ENOG4105DJ4 phosphatidylserine decarboxylase G5C61_RS10490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G5C61_RS10500 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS10515 ENOG4105C28 cystathionine G5C61_RS10525 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G5C61_RS10530 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) G5C61_RS10545 ENOG4107XRG penicillin-binding protein G5C61_RS10550 ENOG4105D3W isochorismatase G5C61_RS10555 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G5C61_RS10560 ENOG4105DBI uridine monophosphokinase G5C61_RS10565 ENOG4105CFP Peptidase U32 G5C61_RS10570 ENOG4105XYU peptidase (U32 family) G5C61_RS10580 ENOG4105HHA aminodeoxychorismate lyase G5C61_RS10585 ENOG4105VPH UPF0473 protein G5C61_RS10595 ENOG4105VBH UPF0297 protein G5C61_RS10600 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G5C61_RS10605 ENOG4105C02 permease G5C61_RS10615 ENOG41060CR G5C61_RS10620 ENOG4105C7H Helicase, RecD TraA family G5C61_RS10630 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G5C61_RS10635 ENOG4105C3J Cysteine desulfurase G5C61_RS10645 ENOG4105D1H recombination factor protein RarA G5C61_RS10650 ENOG4105E2Z phosphate ABC transporter (Permease G5C61_RS10655 ENOG4105C8U phosphate abc transporter G5C61_RS10660 ENOG4105CVA phosphate G5C61_RS10665 ENOG4105CUZ uba thif-type nad fad binding protein G5C61_RS10675 ENOG4105C9M aspartyl-trna synthetase G5C61_RS10680 ENOG4105CUT histidyl-tRNA synthetase G5C61_RS10690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G5C61_RS10695 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G5C61_RS10700 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G5C61_RS10705 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G5C61_RS10710 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G5C61_RS10715 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G5C61_RS10725 ENOG4105CKP Polysaccharide Biosynthesis Protein G5C61_RS10730 ENOG4108QG2 Membrane G5C61_RS10735 ENOG4105NAP G5C61_RS10740 ENOG4105VIE preprotein translocase, subunit YajC G5C61_RS10750 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G5C61_RS10755 ENOG41061AI Protein of unknown function (DUF2905) G5C61_RS10760 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G5C61_RS10790 ENOG4106678 morphogenetic protein associated with SpoVID G5C61_RS10795 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G5C61_RS10800 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G5C61_RS10805 ENOG4108IYU L-aspartate oxidase G5C61_RS10820 ENOG4105CQC Prephenate dehydratase G5C61_RS10825 ENOG41090I5 UPF0735 ACT domain-containing protein G5C61_RS10830 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G5C61_RS10840 ENOG4105K46 50S ribosomal protein l27 G5C61_RS10845 ENOG4105X36 (ribosomal) protein G5C61_RS10855 ENOG4105C03 ribonuclease G5C61_RS10870 ENOG4107QMS site-determining protein G5C61_RS10875 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G5C61_RS10880 ENOG4105YHC Rod shape-determining protein MreD G5C61_RS10885 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G5C61_RS10890 ENOG4105DFF Rod shape-determining protein mreb G5C61_RS10895 ENOG4105W5Q DNA repair protein (RadC G5C61_RS10910 ENOG4106A3R peptidase G5C61_RS10920 ENOG4108SJC Membrane G5C61_RS10925 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G5C61_RS10930 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G5C61_RS10940 ENOG4106AR7 Spore coat protein G5C61_RS10945 ENOG41068KH stage VI sporulation protein D G5C61_RS10950 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G5C61_RS10955 ENOG4105D52 delta-aminolevulinic acid dehydratase G5C61_RS10965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G5C61_RS10975 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G5C61_RS10985 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G5C61_RS10990 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G5C61_RS10995 ENOG4108IUQ atp-dependent protease G5C61_RS11000 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G5C61_RS11005 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G5C61_RS11015 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G5C61_RS11020 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G5C61_RS11030 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G5C61_RS11035 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G5C61_RS11040 ENOG4108ZP8 Acetolactate synthase small subunit G5C61_RS11045 ENOG4105C7K acetolactate synthase G5C61_RS11055 ENOG4105M59 Phosphodiesterase, mj0936 family G5C61_RS11065 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G5C61_RS11070 ENOG4108XJQ germination protein G5C61_RS11075 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G5C61_RS11080 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS11085 ENOG4108QCI YvbH-like oligomerisation region G5C61_RS11090 ENOG4105CJ3 phosphate transporter G5C61_RS11095 ENOG4107GRR phosphate transport regulator G5C61_RS11100 ENOG4107RVG penicillin-binding protein G5C61_RS11110 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G5C61_RS11115 ENOG4108UZX fmn reductase G5C61_RS11120 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G5C61_RS11125 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein G5C61_RS11130 ENOG4105D7T ABC transporter G5C61_RS11135 ENOG4107S91 Sodium hydrogen exchanger G5C61_RS11140 ENOG4105NCW Trka-c domain protein G5C61_RS11150 ENOG4105PFC Transcriptional regulator G5C61_RS11160 ENOG4105E33 succinate dehydrogenase G5C61_RS11170 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit G5C61_RS11180 ENOG4105CFH Aspartokinase G5C61_RS11190 ENOG4105K63 Thioredoxin G5C61_RS11195 ENOG4105C10 Electron transfer flavoprotein G5C61_RS11200 ENOG4105BZJ Electron transfer flavoprotein G5C61_RS11205 ENOG41060WC Enoyl-CoA hydratase G5C61_RS11210 ENOG4107Z3H Transcriptional regulator, TetR family G5C61_RS11215 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS11230 ENOG4105C98 muts2 protein G5C61_RS11235 ENOG4105DCG PHP domain protein G5C61_RS11245 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) G5C61_RS11250 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G5C61_RS11255 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G5C61_RS11265 ENOG4108RWN rrna methyltransferase G5C61_RS11270 ENOG41067MF small acid-soluble spore protein G5C61_RS11275 ENOG4105CN9 Peptidase m42 family protein G5C61_RS11295 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G5C61_RS11300 ENOG4105VJV 50s ribosomal protein L35 G5C61_RS11305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G5C61_RS11310 ENOG4105C22 threonyL-tRNA synthetase G5C61_RS11315 ENOG4108TDW sporulation protein YtxC G5C61_RS11330 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G5C61_RS11340 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G5C61_RS11345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G5C61_RS11350 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G5C61_RS11360 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G5C61_RS11365 ENOG4105C2M dna polymerase I G5C61_RS11370 ENOG4105BZU Histidine kinase G5C61_RS11375 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G5C61_RS11385 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G5C61_RS11390 ENOG4108HMX isocitrate dehydrogenase (NADP) G5C61_RS11395 ENOG4105BZN citrate synthase G5C61_RS11400 ENOG4107CWS Protein of unknown function (DUF441) G5C61_RS11405 ENOG4108REF Sporulation integral membrane protein ytvi G5C61_RS11410 ENOG4105FS0 cytoplasmic membrane protein G5C61_RS11415 ENOG4105CA9 Pyruvate kinase G5C61_RS11420 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G5C61_RS11425 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G5C61_RS11430 ENOG4107YCY Transcriptional regulator G5C61_RS11435 ENOG4105C6K Malic enzyme G5C61_RS11440 ENOG4105C0B DNA polymerase III (alpha subunit) G5C61_RS11445 ENOG4105VV2 G5C61_RS11455 ENOG4105SFS phosphoesterase RecJ domain protein G5C61_RS11480 ENOG4105E8R UPF0173 metal-dependent hydrolase G5C61_RS11495 ENOG4105CH7 arginosuccinase G5C61_RS11500 ENOG4105CDH Citrulline--aspartate ligase G5C61_RS11515 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G5C61_RS11525 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G5C61_RS11530 ENOG4105KBJ sporulation protein ytfj G5C61_RS11540 ENOG4105VK3 rdd domain containing protein G5C61_RS11545 ENOG4105D07 Signal peptide peptidase, SppA G5C61_RS11550 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G5C61_RS11555 ENOG4105EFZ amidohydrolase G5C61_RS11565 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) G5C61_RS11580 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) G5C61_RS11585 ENOG4108W76 histidinol phosphate phosphatase hisj family G5C61_RS11590 ENOG4105U5Y Transcriptional regulator G5C61_RS11600 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G5C61_RS11615 ENOG4105F1V Acetoin utilization protein G5C61_RS11620 ENOG4105W87 Cbs domain G5C61_RS11625 ENOG4105DGU Histone deacetylase G5C61_RS11630 ENOG4106VK6 Flagellar motor protein G5C61_RS11635 ENOG4105E14 MotA TolQ exbB proton channel G5C61_RS11640 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS11645 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G5C61_RS11670 ENOG4105DFU Cell wall formation (By similarity) G5C61_RS11685 ENOG4108VDD TRNA binding domain protein G5C61_RS11690 ENOG4108NKM UPF0354 protein G5C61_RS11700 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G5C61_RS11715 ENOG4105C8F Beta-lactamase domain protein G5C61_RS11720 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G5C61_RS11730 ENOG4108V15 phosphotransferase enzyme family G5C61_RS11735 ENOG4108IUM Glycogen debranching enzyme G5C61_RS11745 ENOG4107F58 2'-5' rna ligase G5C61_RS11750 ENOG4105C6T cysteine synthase G5C61_RS11755 ENOG4107QSE Dipeptidase G5C61_RS11760 ENOG4105YW5 deoR family transcriptional regulator G5C61_RS11775 ENOG4105CBX hi0933 family G5C61_RS11785 ENOG41085GJ domain protein G5C61_RS11790 ENOG4105C8T Leucyl-tRNA synthetase G5C61_RS11800 ENOG4105CY2 Citrate transporter G5C61_RS11805 ENOG410605W Major Facilitator G5C61_RS11820 ENOG4105N5T Radical SAM Protein G5C61_RS11835 ENOG4105E8V Alpha Beta Hydrolase Fold protein G5C61_RS11840 ENOG4108Z0R Transferase G5C61_RS11845 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G5C61_RS11850 ENOG4105BZF Glycosyl transferase (Group 1 G5C61_RS11855 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G5C61_RS11860 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase G5C61_RS11875 ENOG4105D2X ABC transporter substrate-binding protein G5C61_RS11885 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component G5C61_RS11905 ENOG4108RMU ferritin dps family protein G5C61_RS11910 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) G5C61_RS11915 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G5C61_RS11920 ENOG4108V2W Carbonate dehydratase G5C61_RS11925 ENOG4105CKI cobalamin synthesis protein G5C61_RS11935 ENOG4105NRA 50s ribosomal protein l31 type b G5C61_RS11950 ENOG4105NQC Flavodoxin G5C61_RS11975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G5C61_RS11980 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G5C61_RS11985 ENOG4105DTQ mandelate racemase muconate lactonizing G5C61_RS11990 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS11995 ENOG4108IPT Naphthoate synthase G5C61_RS12000 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G5C61_RS12005 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) G5C61_RS12010 ENOG4105E4F Isochorismate synthase G5C61_RS12030 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G5C61_RS12170 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS12175 ENOG4105KT7 mgtC SapB transporter G5C61_RS12180 ENOG4108Z73 Siroheme synthase G5C61_RS12185 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G5C61_RS12190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G5C61_RS12195 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) G5C61_RS12225 ENOG4107PBV potassium channel G5C61_RS12235 ENOG4107QYV phosphohexose isomerase G5C61_RS12245 ENOG4105D65 subunit l G5C61_RS12250 ENOG4105HC0 Na H antiporter G5C61_RS12255 ENOG4108ZE9 Monovalent cation H antiporter subunit C G5C61_RS12260 ENOG4108JPZ Monovalent cation H antiporter subunit D G5C61_RS12265 ENOG4105SC1 monovalent cation H antiporter subunit E G5C61_RS12275 ENOG4105KJM monovalent cation h antiporter subunit g G5C61_RS12280 ENOG4107QW4 alcohol dehydrogenase G5C61_RS12285 ENOG4105WG9 Conserved Protein G5C61_RS12295 ENOG4105CHM Aminotransferase G5C61_RS12300 ENOG4108ZB6 transcriptional regulator AsnC family G5C61_RS12305 ENOG4108MUZ hydrolase G5C61_RS12310 ENOG4105C87 Aminotransferase class I and II G5C61_RS12315 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G5C61_RS12325 ENOG4105Y38 Kinase-associated protein B G5C61_RS12335 ENOG4105KA0 thioesterase Superfamily protein G5C61_RS12360 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G5C61_RS12370 ENOG41069ER domain protein G5C61_RS12380 ENOG4105CEP NADH dehydrogenase G5C61_RS12395 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G5C61_RS12405 ENOG4105ZKE UPF0349 protein G5C61_RS12420 ENOG41083MR nifu domain-containing protein G5C61_RS12425 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G5C61_RS12430 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G5C61_RS12435 ENOG4105D6E homoserine dehydrogenase G5C61_RS12440 ENOG4105C5I Dehydrogenase G5C61_RS12450 ENOG4108W5N phosphatidylglycerophosphatase a G5C61_RS12455 ENOG4105D4U had-superfamily hydrolase, subfamily iia G5C61_RS12470 ENOG4105MMD transcriptional regulator G5C61_RS12475 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) G5C61_RS12480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G5C61_RS12485 ENOG4105FAA peptidase M23 G5C61_RS12495 ENOG4105C8J )-transporter G5C61_RS12500 ENOG4108YTE sporulation protein YunB G5C61_RS12505 ENOG4105KZD Domain of unknown function (DUF1805) G5C61_RS12510 ENOG4105I3N Conserved Protein G5C61_RS12515 ENOG4105DIW FeS assembly protein SUFB G5C61_RS12520 ENOG4108UNV SUF system FeS assembly protein, NifU family G5C61_RS12525 ENOG4105C9B Cysteine desulfurase G5C61_RS12530 ENOG4105JRK feS assembly protein SufD G5C61_RS12535 ENOG4105C3K feS assembly ATPase SufC G5C61_RS12545 ENOG4105D01 (LipO)protein G5C61_RS12550 ENOG4108UMI ABC transporter, permease G5C61_RS12555 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS12575 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G5C61_RS12580 ENOG41080E8 Transcriptional regulator, Spx MgsR family G5C61_RS12585 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS12590 ENOG4105CHU acetyl-coa acetyltransferase G5C61_RS12620 ENOG4105E0A ABC, transporter G5C61_RS12625 ENOG4108IHU transport system permease protein G5C61_RS12630 ENOG4105DQ5 transport system permease protein G5C61_RS12635 ENOG4108MES Periplasmic binding protein G5C61_RS12655 ENOG41067SE Tetr family transcriptional regulator G5C61_RS12665 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G5C61_RS12670 ENOG41079KZ Major Facilitator Superfamily G5C61_RS12675 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G5C61_RS12685 ENOG41062D9 Histidine kinase G5C61_RS12690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS12700 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G5C61_RS12705 ENOG4105FS7 Transcriptional regulator G5C61_RS12710 ENOG4108TVJ Nitroreductase G5C61_RS12715 ENOG41067WU Molybdopterin converting factor (Subunit 1) G5C61_RS12720 ENOG4108ZAF Molybdopterin G5C61_RS12725 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein G5C61_RS12730 ENOG4105CVM Molybdenum cofactor synthesis domain protein G5C61_RS12735 ENOG4105D06 uba thif-type nad fad binding protein G5C61_RS12740 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G5C61_RS12750 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G5C61_RS12755 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) G5C61_RS12760 ENOG4108JB9 formate dehydrogenase G5C61_RS12770 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G5C61_RS12775 ENOG4105E0C molybdate abc transporter G5C61_RS12785 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G5C61_RS12790 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G5C61_RS12800 ENOG4105XZU Preprotein translocase, subunit SecG G5C61_RS12840 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS12860 ENOG4105KRI phosphocarrier protein (HPr G5C61_RS12870 ENOG4105CHW UPF0052 protein G5C61_RS12875 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G5C61_RS12880 ENOG4108Z4K mutator MutT protein G5C61_RS12885 ENOG4105C3M thioredoxin reductase G5C61_RS12895 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G5C61_RS12900 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G5C61_RS12905 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G5C61_RS12910 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G5C61_RS12915 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G5C61_RS12920 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G5C61_RS12925 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G5C61_RS12930 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G5C61_RS12935 ENOG4108S4C acetyltransferase G5C61_RS12940 ENOG4107XGZ Hydrolase G5C61_RS12945 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G5C61_RS12950 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G5C61_RS12955 ENOG41086DT Membrane protein of unknown function G5C61_RS12965 ENOG4108PY7 G5C61_RS12975 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G5C61_RS12980 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G5C61_RS12985 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G5C61_RS13005 ENOG4105CN1 protease G5C61_RS13015 ENOG4105CRP Part of the ABC transporter FtsEX involved in G5C61_RS13020 ENOG4105CAK Cell division ATP-binding protein ftsE G5C61_RS13025 ENOG4108WS4 fmn reductase G5C61_RS13035 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G5C61_RS13040 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G5C61_RS13045 ENOG4105DGI Alkaline phosphatase G5C61_RS13055 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G5C61_RS13060 ENOG4105SUU thioesterase domain G5C61_RS13065 ENOG4105MS2 ribosomal subunit Interface protein G5C61_RS13075 ENOG4105MQ3 flagellar protein FliS G5C61_RS13080 ENOG4107RT6 flagellar hook-associated G5C61_RS13090 ENOG4105C85 amino acid G5C61_RS13105 ENOG4108JB8 alcohol dehydrogenase G5C61_RS13110 ENOG4105TRT Transcriptional regulator G5C61_RS13115 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G5C61_RS13120 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) G5C61_RS13125 ENOG4105DTJ flagellar hook-associated protein G5C61_RS13130 ENOG4105E1Q flagellar hook-associated protein G5C61_RS13150 ENOG41081UC Inherit from COG: Competence protein G5C61_RS13165 ENOG4105XVJ Protein of unknown function (DUF327) G5C61_RS13175 ENOG4105WH1 Two component transcriptional regulator luxr family G5C61_RS13180 ENOG4105BZU Histidine kinase G5C61_RS13185 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G5C61_RS13190 ENOG4108KGH TRANSCRIPTIONal G5C61_RS13195 ENOG4105ESV Glycosyl transferase, family 4 G5C61_RS13205 ENOG4105DZ6 Band 7 protein G5C61_RS13220 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G5C61_RS13230 ENOG4105C0D helicase G5C61_RS13240 ENOG4105Z8H single-stranded DNA-binding protein G5C61_RS13260 ENOG4105CGA flagellar basal-body rod protein FlgG G5C61_RS13270 ENOG4105DFF Rod shape-determining protein mreb G5C61_RS13275 ENOG4105MT0 Sporulation transcriptional regulator spoiiid G5C61_RS13280 ENOG4105FRN stage II sporulation protein G5C61_RS13300 ENOG4106778 Protein of unknown function (DUF1146) G5C61_RS13305 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G5C61_RS13310 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G5C61_RS13315 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G5C61_RS13320 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G5C61_RS13325 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G5C61_RS13330 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) G5C61_RS13335 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G5C61_RS13340 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) G5C61_RS13345 ENOG41062M3 atp synthase G5C61_RS13355 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin G5C61_RS13360 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G5C61_RS13365 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G5C61_RS13380 ENOG4108YZG isomerase G5C61_RS13395 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G5C61_RS13405 ENOG4108ZXQ stage ii sporulation protein r G5C61_RS13410 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G5C61_RS13415 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G5C61_RS13425 ENOG4105VFB Binds the 23S rRNA (By similarity) G5C61_RS13430 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G5C61_RS13435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G5C61_RS13440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G5C61_RS13445 ENOG4105D2N Aldolase G5C61_RS13460 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G5C61_RS13470 ENOG4105D5P Methylmalonyl-coA mutase G5C61_RS13480 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS13485 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS13490 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G5C61_RS13500 ENOG4105DF6 Fe-S oxidoreductase G5C61_RS13515 ENOG4105C75 arginyL-tRNA synthetase G5C61_RS13520 ENOG410684U Domain of unknown function (DUF1934) G5C61_RS13525 ENOG4105CYW agmatinase G5C61_RS13530 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G5C61_RS13535 ENOG4105BZ4 penicillin-binding protein G5C61_RS13540 ENOG4108XFG YwhD family G5C61_RS13545 ENOG4108Z4T Peptidase M50 G5C61_RS13550 ENOG41069HH 4-oxalocrotonate tautomerase G5C61_RS13560 ENOG4105DCI Phosphohydrolase G5C61_RS13570 ENOG4108VCI transcription factor, rsfa family G5C61_RS13580 ENOG4108IJ2 phosphate acetyltransferase G5C61_RS13585 ENOG4107JTW chlorite dismutase G5C61_RS13590 ENOG4108VKI Cell wall hydrolase G5C61_RS13610 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G5C61_RS13620 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G5C61_RS13625 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G5C61_RS13630 ENOG4108K8K Transcriptional regulator G5C61_RS13635 ENOG4105DCF alanine dehydrogenase G5C61_RS13645 ENOG4105DWF phosphomethylpyrimidine kinase G5C61_RS13650 ENOG4105J7I hydrolase G5C61_RS13655 ENOG4107URF beta-phospho-glucomutase G5C61_RS13660 ENOG4105CI1 PTS System G5C61_RS13670 ENOG4105CPK Glycosyl transferase (Group 1 G5C61_RS13675 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 G5C61_RS13685 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G5C61_RS13695 ENOG4105CJR Integral membrane protein (MviN G5C61_RS13710 ENOG4108JJ8 (ABC) transporter G5C61_RS13715 ENOG4108JJ9 ABC, transporter G5C61_RS13720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G5C61_RS13725 ENOG4105C4M (Ubiquinol oxidase) subunit I G5C61_RS13730 ENOG4107XM3 UPF0442 protein G5C61_RS13735 ENOG4105DWK Membrane G5C61_RS13740 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS13785 ENOG4107QPK )-transporter G5C61_RS13790 ENOG4105DR4 Methyltransferase G5C61_RS13805 ENOG4105BZU Histidine kinase G5C61_RS13825 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G5C61_RS13835 ENOG4105C0H protease G5C61_RS13840 ENOG4105Q2H domain protein G5C61_RS13855 ENOG4105BZU Histidine kinase G5C61_RS13860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS13885 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G5C61_RS13890 ENOG4105CDU Replicative dna helicase G5C61_RS13900 ENOG4105BZR domain protein G5C61_RS13910 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G5C61_RS13915 ENOG4108UUM single-stranded DNA-binding protein G5C61_RS13925 ENOG4105C3G gtp-binding protein G5C61_RS13930 ENOG4105VDK protein, conserved in bacteria G5C61_RS13935 ENOG4105D8X mechanosensitive ion channel G5C61_RS13945 ENOG4108ZDA Sporulation protein YyaC G5C61_RS13950 ENOG4105FA0 parb-like partition protein G5C61_RS13955 ENOG4107QJE Chromosome Partitioning Protein G5C61_RS13960 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) G5C61_RS13970 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G5C61_RS13975 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G5C61_RS13985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G5C61_RS13990 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G5C61_RS13995 ENOG4105VG0 50S ribosomal protein l34 G5C61_RS14000 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G5C61_RS14005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G5C61_RS14010 ENOG410848D S4 domain protein YaaA G5C61_RS14020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G5C61_RS14025 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G5C61_RS14060 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G5C61_RS14070 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G5C61_RS14075 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G5C61_RS14090 ENOG4105ZMH deoxynucleoside kinase G5C61_RS14100 ENOG4105VRS hydrolase family 18 G5C61_RS14105 ENOG4105GTG Isochorismatase G5C61_RS14110 ENOG4108Z6B deaminase G5C61_RS14120 ENOG4105C6E dna polymerase iii G5C61_RS14125 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G5C61_RS14130 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G5C61_RS14140 ENOG41067KS pro-sigma K processing G5C61_RS14235 ENOG4105CXN decarboxylase G5C61_RS14240 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G5C61_RS14245 ENOG4105X0R protein from nitrogen regulatory protein P-II G5C61_RS14250 ENOG4105FA2 dna polymerase iii G5C61_RS14255 ENOG4105MA4 psp1 domain protein G5C61_RS14260 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) G5C61_RS14265 ENOG41060K3 Methyltransferase G5C61_RS14270 ENOG4105VC4 domain protein G5C61_RS14275 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G5C61_RS14280 ENOG4105KRN Transcriptional regulator, abrb family G5C61_RS14285 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G5C61_RS14290 ENOG4105F8V Hydrolase, tatD family G5C61_RS14295 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) G5C61_RS14300 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G5C61_RS14305 ENOG4105XFA sporulation peptidase YabG G5C61_RS14310 ENOG4105W42 Veg protein G5C61_RS14325 ENOG4105DFT pur operon repressor G5C61_RS14330 ENOG4105KME endoribonuclease L-psp G5C61_RS14335 ENOG4105K4W Could be involved in septation (By similarity) G5C61_RS14340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G5C61_RS14350 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G5C61_RS14355 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G5C61_RS14365 ENOG4108JA2 transcriptioN-repair coupling factor G5C61_RS14370 ENOG4108M14 stage v sporulation protein t G5C61_RS14380 ENOG4108IY2 MazG family G5C61_RS14385 ENOG41082I2 s4 domain protein G5C61_RS14390 ENOG4105VYY sporulation protein yabp G5C61_RS14405 ENOG41060GV RNA binding s1 domain protein G5C61_RS14420 ENOG4105G3A stage ii sporulation protein e G5C61_RS14435 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G5C61_RS14440 ENOG4108UGV hypoxanthine phosphoribosyltransferase G5C61_RS14445 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G5C61_RS14450 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G5C61_RS14455 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G5C61_RS14460 ENOG4105C6T cysteine synthase G5C61_RS14465 ENOG4105CRQ synthase (Component I) G5C61_RS14470 ENOG4105DDQ anthranilate synthase G5C61_RS14475 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 G5C61_RS14480 ENOG4105KRF dihydroneopterin aldolase G5C61_RS14485 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G5C61_RS14490 ENOG4105CRK lysyL-tRNA synthetase G5C61_RS14515 ENOG4108Z0C Uvrb UvrC protein G5C61_RS14520 ENOG41066A3 ATP guanido phosphotransferase G5C61_RS14530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G5C61_RS14535 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G5C61_RS14540 ENOG4105CTP PilT protein domain protein G5C61_RS14545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G5C61_RS14550 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G5C61_RS14555 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G5C61_RS14560 ENOG4105D7W serine acetyltransferase G5C61_RS14565 ENOG4105C8N cysteinyl-tRNA synthetase G5C61_RS14575 ENOG4105C2N RNA methyltransferase TrmH family group 3 G5C61_RS14580 ENOG4105M0M Tetracycline resistance protein G5C61_RS14585 ENOG4105QIV RNA polymerase G5C61_RS14590 ENOG41087NY 50S ribosomal protein L33 G5C61_RS14600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G5C61_RS14610 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G5C61_RS14615 ENOG4108VZM 50s ribosomal protein L10 G5C61_RS14625 ENOG4107Y49 methyltransferase G5C61_RS14630 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G5C61_RS14635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G5C61_RS14640 ENOG4105XPM ribosomal protein G5C61_RS14645 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G5C61_RS14650 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G5C61_RS14660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G5C61_RS14670 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G5C61_RS14675 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G5C61_RS14680 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G5C61_RS14685 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G5C61_RS14690 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G5C61_RS14695 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G5C61_RS14700 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G5C61_RS14705 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G5C61_RS14710 ENOG41082SA 50s ribosomal protein l29 G5C61_RS14715 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G5C61_RS14720 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G5C61_RS14735 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G5C61_RS14740 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G5C61_RS14745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G5C61_RS14750 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G5C61_RS14755 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G5C61_RS14760 ENOG4105VPB 50S ribosomal protein L30 G5C61_RS14765 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G5C61_RS14770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G5C61_RS14775 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G5C61_RS14780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G5C61_RS14785 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G5C61_RS14790 ENOG41067V7 50S ribosomal protein L36 G5C61_RS14795 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G5C61_RS14805 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G5C61_RS14810 ENOG4108ZT0 50S ribosomal protein l17 G5C61_RS14815 ENOG4108JJB ABC transporter G5C61_RS14820 ENOG4108JJB ABC transporter G5C61_RS14825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) G5C61_RS14830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G5C61_RS14835 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G5C61_RS14855 ENOG4105D1F ATP-binding protein G5C61_RS14860 ENOG4108KSA LysR family transcriptional regulator G5C61_RS14875 ENOG4108NMV polysaccharide deacetylase G5C61_RS14955 ENOG4105EMN RNA polymerase sigma factor G5C61_RS14965 ENOG4105C8B TIGR00159 family G5C61_RS14975 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G5C61_RS14980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G5C61_RS14990 ENOG4105K4H Nlp p60 protein G5C61_RS14995 ENOG4105CTS PTS system mannitol-specific G5C61_RS15000 ENOG4105ETD TRANSCRIPTIONal G5C61_RS15005 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase G5C61_RS15015 ENOG4108VZI ErfK ybiS ycfS ynhG family protein G5C61_RS15020 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G5C61_RS15025 ENOG4107T7U Sulfatase G5C61_RS15045 ENOG4105D38 putrescine abc transporter G5C61_RS15050 ENOG4107RUE extracellular solute-binding protein family 1 G5C61_RS15060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS15065 ENOG4105US7 Histidine kinase G5C61_RS15075 ENOG41081YB ApbE family G5C61_RS15080 ENOG4105I7V membrAne G5C61_RS15085 ENOG4105CPF Cell wall formation (By similarity) G5C61_RS15090 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) G5C61_RS15095 ENOG4105C1J atp-dependent rna helicase G5C61_RS15110 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G5C61_RS15115 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein G5C61_RS15120 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G5C61_RS15130 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) G5C61_RS15135 ENOG4107MMM Anti-sigma-factor antagonist G5C61_RS15140 ENOG4105FUA antagonist G5C61_RS15145 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G5C61_RS15150 ENOG4107SGM protein serine threonine phosphatase G5C61_RS15155 ENOG4105WN5 stage II sporulation protein G5C61_RS15170 ENOG41064BQ Phosphatase G5C61_RS15270 ENOG4105K8N protein family UPF0079, ATPase G5C61_RS15275 ENOG41072GX Peptidase M22 Glycoprotease G5C61_RS15280 ENOG410801F ribosomal-protein-alanine acetyltransferase G5C61_RS15285 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G5C61_RS15290 ENOG4105C5H ABC transporter G5C61_RS15295 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) G5C61_RS15300 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G5C61_RS15305 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G5C61_RS15315 ENOG4108TYN CAAX amino terminal protease family protein G5C61_RS15320 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G5C61_RS15325 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G5C61_RS15330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G5C61_RS15335 ENOG4107S2N Type III effector Hrp-dependent G5C61_RS15340 ENOG4105C0A alcohol dehydrogenase G5C61_RS15345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G5C61_RS15350 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G5C61_RS15375 ENOG4105CHR reductase G5C61_RS15380 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G5C61_RS15395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G5C61_RS15400 ENOG4105C7N Xanthine uracil vitamin C permease G5C61_RS15440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G5C61_RS15445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G5C61_RS15450 ENOG4105C83 adenylosuccinate lyase G5C61_RS15455 ENOG4105C8V SAICAR synthetase G5C61_RS15460 ENOG4105VR9 phosphoribosylformylglycinamidine synthase G5C61_RS15465 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G5C61_RS15470 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G5C61_RS15480 ENOG4105CXB phosphoribosylaminoimidazole synthetase G5C61_RS15485 ENOG4108V3E phosphoribosylglycinamide formyltransferase G5C61_RS15490 ENOG4105DC1 bifunctional purine biosynthesis protein purh G5C61_RS15495 ENOG4105C12 Phosphoribosylglycinamide synthetase G5C61_RS15510 ENOG4105KGF protein, YerC YecD G5C61_RS15515 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G5C61_RS15525 ENOG4105C4R Atp-dependent dna helicase G5C61_RS15530 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G5C61_RS15545 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G5C61_RS15550 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G5C61_RS15555 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G5C61_RS15560 ENOG4105CBD Diacylglycerol kinase G5C61_RS15565 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G5C61_RS15570 ENOG4107AYK membrAne G5C61_RS15585 ENOG4107RMD Basic membrane lipoprotein G5C61_RS15590 ENOG4105BZU Histidine kinase G5C61_RS15595 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G5C61_RS15600 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G5C61_RS15605 ENOG4105EA8 2-Nitropropane dioxygenase G5C61_RS15610 ENOG4108Z5V transcriptional regulator, merr family G5C61_RS15615 ENOG4105C2C drug resistance transporter, Bcr CflA G5C61_RS15630 ENOG4105CDA abc transporter atp-binding protein G5C61_RS15635 ENOG4105CT1 (ABC) transporter G5C61_RS15640 ENOG4105EAD ABC transporter G5C61_RS15645 ENOG4105DRP amino acid AbC transporter G5C61_RS15655 ENOG4106BRA Membrane G5C61_RS15670 ENOG41062D9 Histidine kinase G5C61_RS15675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS15685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G5C61_RS15705 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G5C61_RS15710 ENOG4108ZHJ Organic hydroperoxide resistance protein G5C61_RS15730 ENOG4107R7Y intracellular protease Pfpi family G5C61_RS15740 ENOG4106DF1 G5C61_RS15750 ENOG4105BZG amino acid carrier protein G5C61_RS15770 ENOG4105D7N magnesium and cobalt transport protein CorA G5C61_RS15780 ENOG4108MRH transcriptional regulatory protein G5C61_RS15795 ENOG4105BZU Histidine kinase G5C61_RS15800 ENOG4105FDU atp-dependent rna helicase G5C61_RS15810 ENOG4108IBT Inherit from COG: transposase G5C61_RS15860 ENOG4108K8S endonuclease I G5C61_RS15870 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G5C61_RS15885 ENOG4105C5H ABC transporter G5C61_RS15890 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G5C61_RS15905 ENOG4105KPV Transcriptional regulator G5C61_RS15910 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G5C61_RS15915 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) G5C61_RS15920 ENOG4108Z0Z intracellular protease Pfpi family G5C61_RS15925 ENOG4105K4I Scp-like extracellular G5C61_RS15930 ENOG4105CPN adenine deaminase G5C61_RS15940 ENOG4105KJF protein tyrosine phosphatase G5C61_RS15950 ENOG4107U9T Pfam:Ribonuclease_BN G5C61_RS15955 ENOG4105C59 p-type ATPase G5C61_RS15965 ENOG4105KTU Transcriptional regulator, arsr family G5C61_RS15970 ENOG4105PGM cation diffusion facilitator family transporter G5C61_RS15975 ENOG4108ISG Major Facilitator G5C61_RS15980 ENOG4105NI3 Protein of unknown function (DUF3237) G5C61_RS15985 ENOG4105PY6 Phenolic acid decarboxylase G5C61_RS15995 ENOG410606W general stress protein G5C61_RS16000 ENOG4105UPD Calcium Proton G5C61_RS16030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G5C61_RS16040 ENOG4105C85 amino acid G5C61_RS16045 ENOG4105BZU Histidine kinase G5C61_RS16065 ENOG4105ECP epimerase G5C61_RS16075 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr G5C61_RS16085 ENOG4105XHU Acid-soluble spore protein K G5C61_RS16095 ENOG41067AE Membrane-bound metal-dependent hydrolase G5C61_RS16100 ENOG4105CEN a g-specific adenine glycosylase G5C61_RS16105 ENOG4106BXE G5C61_RS16110 ENOG4105CAN Short-chain dehydrogenase reductase Sdr G5C61_RS16125 ENOG4105EVI UPF0374 protein G5C61_RS16130 ENOG4105BZ1 (ABC) transporter G5C61_RS16135 ENOG4107NBY Membrane G5C61_RS16145 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G5C61_RS16150 ENOG4108IUW ABC transporter G5C61_RS16170 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G5C61_RS16175 ENOG4105G5W regulator Fur family G5C61_RS16180 ENOG4105TUA UPF0295 protein G5C61_RS16295 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G5C61_RS16305 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G5C61_RS16310 ENOG4105CYN Serine protein kinase G5C61_RS16325 ENOG41076HS cation diffusion facilitator family transporter G5C61_RS16340 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G5C61_RS16350 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G5C61_RS16360 ENOG4108REF Sporulation integral membrane protein ytvi G5C61_RS16365 ENOG4107T5V SNARE associated Golgi G5C61_RS16370 ENOG4105EU9 G5C61_RS16375 ENOG4105CUB amino acid G5C61_RS16395 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G5C61_RS16405 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G5C61_RS16420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G5C61_RS16435 ENOG4105DTQ mandelate racemase muconate lactonizing G5C61_RS16480 ENOG41069ER domain protein G5C61_RS16485 ENOG4108VXD carboxy-peptidase G5C61_RS16505 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G5C61_RS16510 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G5C61_RS16525 ENOG4105YWU small acid-soluble spore protein G5C61_RS16530 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS16535 ENOG4105IE8 Alpha-ketoglutarate permease G5C61_RS16540 ENOG4105CK5 oxidoreductase G5C61_RS16565 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS16580 ENOG4108JYZ YitT family G5C61_RS16605 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS16610 ENOG4105J7D transcriptional regulator G5C61_RS16615 ENOG4105FE9 pseudouridine synthase G5C61_RS16630 ENOG41090U3 tautomerase G5C61_RS16635 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G5C61_RS16650 ENOG4105D4T Citrate transporter G5C61_RS16665 ENOG4108RE7 deoxyribonuclease G5C61_RS16675 ENOG4105FR1 rard protein G5C61_RS16700 ENOG4105CB2 alcohol dehydrogenase G5C61_RS16705 ENOG4105DAA L-lactate G5C61_RS16710 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G5C61_RS16720 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer G5C61_RS16725 ENOG4108YBP pseudouridine synthase G5C61_RS16735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G5C61_RS16740 ENOG4108PXI ErfK YbiS YcfS YnhG G5C61_RS16745 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G5C61_RS16750 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G5C61_RS16760 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G5C61_RS16765 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G5C61_RS16785 ENOG4105ED1 spovr family G5C61_RS16795 ENOG4108Z40 Transcriptional regulator G5C61_RS16810 ENOG4105CDA abc transporter atp-binding protein G5C61_RS16815 ENOG4105DRP amino acid AbC transporter G5C61_RS16840 ENOG4108VEU Thiamine monophosphate synthase G5C61_RS16845 ENOG41080HI glycine oxidase G5C61_RS16860 ENOG4105D06 uba thif-type nad fad binding protein G5C61_RS16865 ENOG4105DWF phosphomethylpyrimidine kinase G5C61_RS16870 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G5C61_RS16890 ENOG4105YWU small acid-soluble spore protein G5C61_RS16920 ENOG410839P G5C61_RS16935 ENOG4105WZB UPF0342 protein G5C61_RS16945 ENOG4105D4P Coproporphyrinogen iii oxidase G5C61_RS16950 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS16955 ENOG4105CGU Enoyl-CoA hydratase G5C61_RS16960 ENOG4105K70 DNA-binding protein G5C61_RS16970 ENOG4108IUX (ABC) transporter G5C61_RS16975 ENOG4105RHA ABC transporter, permease G5C61_RS16980 ENOG4105EQI Metal Dependent Phosphohydrolase G5C61_RS16990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G5C61_RS17015 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) G5C61_RS17025 ENOG4105NBU tryptophan transport protein G5C61_RS17030 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G5C61_RS17035 ENOG4105U3E Transcriptional regulator G5C61_RS17040 ENOG4107YB6 acetyltransferase, (GNAT) family G5C61_RS17045 ENOG4105EXC Acyl-transferase G5C61_RS17050 ENOG4105K59 histidine triad (HIT) protein G5C61_RS17075 ENOG410841Q phosphoesterase PA-phosphatase related protein G5C61_RS17085 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation G5C61_RS17090 ENOG4105BZ4 penicillin-binding protein G5C61_RS17095 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G5C61_RS17100 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G5C61_RS17105 ENOG4105C1Q protoporphyrinogen oxidase G5C61_RS17115 ENOG4107RF6 penicillin-binding protein G5C61_RS17125 ENOG4105C2F Histidine kinase G5C61_RS17140 ENOG4108RQ5 Beta-lactamase domain-containing protein G5C61_RS17145 ENOG4105DF9 Lipoate-protein, ligase G5C61_RS17150 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS17155 ENOG4105E39 Enoyl-CoA hydratase G5C61_RS17270 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 G5C61_RS17285 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G5C61_RS17295 ENOG4105CHR reductase G5C61_RS17305 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G5C61_RS17315 ENOG4105EYH Exonuclease G5C61_RS17360 ENOG4105YHS UPF0344 protein G5C61_RS17370 ENOG4105CAQ asparagine synthetase G5C61_RS17385 ENOG4105FE1 phytoene synthase G5C61_RS17390 ENOG4108YZA Nitrogen regulatory protein pii G5C61_RS17400 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G5C61_RS17405 ENOG4105FKQ transcriptional regulator G5C61_RS17410 ENOG4105C26 Dehydrogenase G5C61_RS17415 ENOG4105C8Y Acetylornithine aminotransferase G5C61_RS17430 ENOG4108JUB Transcriptional regulator G5C61_RS17440 ENOG4108VPT UPF0234 protein G5C61_RS17445 ENOG4105QNR S1 RNA binding domain protein G5C61_RS17455 ENOG4105EPR degv family G5C61_RS17460 ENOG4107AYK membrAne G5C61_RS17475 ENOG4108KP7 hydrolase G5C61_RS17480 ENOG4105VG1 fes assembly suf system protein G5C61_RS17485 ENOG4107V6Q Cyclic nucleotide-binding domain G5C61_RS17490 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G5C61_RS17495 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G5C61_RS17500 ENOG4105CAS nag kinase G5C61_RS17520 ENOG4105DBV ornithine carbamoyltransferase G5C61_RS17540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G5C61_RS17555 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G5C61_RS17560 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase G5C61_RS17565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G5C61_RS17595 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G5C61_RS17600 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G5C61_RS17610 ENOG4105C3U ABC transporter G5C61_RS17615 ENOG4108JQ7 (ABC) transporter G5C61_RS17635 ENOG4108KU1 UPF0736 protein G5C61_RS17640 ENOG4105C31 Tryptophanyl-tRNA synthetase G5C61_RS17645 ENOG4108J59 Extracellular solute-binding protein, family 5 G5C61_RS17650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS17655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS17665 ENOG4108JQ7 (ABC) transporter G5C61_RS17675 ENOG4105C85 amino acid G5C61_RS17685 ENOG4105D5Q Arginine ornithine antiporter G5C61_RS17690 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) G5C61_RS17695 ENOG4107RSM transcriptional regulator G5C61_RS17710 ENOG4108ZCF integral membrane protein G5C61_RS17720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G5C61_RS17730 ENOG4105DPN Oligoendopeptidase f G5C61_RS17740 ENOG4105T58 Dithiol-disulfide isomerase G5C61_RS17745 ENOG4108Z18 K06886 hemoglobin G5C61_RS17750 ENOG4105E4C Lytic transglycosylase catalytic G5C61_RS17755 ENOG4105MIX Adenylate cyclase G5C61_RS17775 ENOG4105EMS pseudouridine synthase G5C61_RS17780 ENOG4107S1Q Phosphatase G5C61_RS17785 ENOG4105CJW magnesium transporter G5C61_RS17850 ENOG4105ENA helicase G5C61_RS17860 ENOG4105H67 Protein of unknown function (DUF421) G5C61_RS17870 ENOG4108ZMI UPF0477 protein G5C61_RS17895 ENOG4106KNT transcriptional regulator G5C61_RS17905 ENOG4105CMG Carbohydrate kinase G5C61_RS17910 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G5C61_RS17915 ENOG4105C6Z Gluconate G5C61_RS17935 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G5C61_RS17940 ENOG4107ZXU DSBA oxidoreductase G5C61_RS17955 ENOG4105C1J atp-dependent rna helicase G5C61_RS17960 ENOG4106N3A copper homeostasis protein cutc G5C61_RS17965 ENOG4105C85 amino acid G5C61_RS17975 ENOG4108W8B Beta-lactamase domain protein G5C61_RS17985 ENOG4105EMD TRANSCRIPTIONal G5C61_RS17990 ENOG4105VZJ PTS System G5C61_RS17995 ENOG4105CK1 PTS System G5C61_RS18000 ENOG4105VCP PTS System G5C61_RS18005 ENOG4105F8D glycoside hydrolase family 4 G5C61_RS18010 ENOG4108HRK Histidine kinase G5C61_RS18015 ENOG4105DY9 regulatoR G5C61_RS18020 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) G5C61_RS18025 ENOG41067MG lrgb family G5C61_RS18035 ENOG4108IFG nitrite reductase, (NAD(P)H) G5C61_RS18040 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G5C61_RS18050 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G5C61_RS18065 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) G5C61_RS18090 ENOG4107FQX Alpha-acetolactate decarboxylase G5C61_RS18115 ENOG4105KVH Transcriptional regulator G5C61_RS18120 ENOG4105F27 Major Facilitator G5C61_RS18125 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G5C61_RS18145 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) G5C61_RS18170 ENOG4105CSV Glutaminase G5C61_RS18180 ENOG4105E1V na solute symporter G5C61_RS18190 ENOG4105Q95 Cupin 2, conserved barrel domain protein G5C61_RS18195 ENOG4107QTZ amino acid G5C61_RS18205 ENOG4108S4H thioesterase Superfamily protein G5C61_RS18210 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G5C61_RS18225 ENOG4105C4B ABC transporter, permease G5C61_RS18230 ENOG4108IXI (ABC) transporter G5C61_RS18245 ENOG4107X8C Efflux transporter RND family MFP subunit G5C61_RS18250 ENOG4105C19 ABC transporter G5C61_RS18255 ENOG4107RBB ABC transporter, permease G5C61_RS18265 ENOG4105EEI dihydropteroate synthase G5C61_RS18270 ENOG4105E2A Dehydrogenase G5C61_RS18290 ENOG4108IQI permease G5C61_RS18300 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G5C61_RS18305 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G5C61_RS18315 ENOG4108ZCF integral membrane protein G5C61_RS18325 ENOG4105CK2 sodium dicarboxylate symporter G5C61_RS18330 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G5C61_RS18335 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G5C61_RS18340 ENOG4108MRH transcriptional regulatory protein G5C61_RS18345 ENOG4105CSC Glucose uptake protein G5C61_RS18350 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G5C61_RS18370 ENOG4107D63 G5C61_RS18375 ENOG4105VZ8 Transcriptional regulator G5C61_RS18385 ENOG4105E0M Sulfatase G5C61_RS18400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS18405 ENOG4108J5H Homocysteine s-methyltransferase G5C61_RS18410 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G5C61_RS18425 ENOG4105D4T Citrate transporter G5C61_RS18435 ENOG4108MRH transcriptional regulatory protein G5C61_RS18450 ENOG4108KAM Transcriptional regulator G5C61_RS18455 ENOG4108KK1 membrane protein AbrB duplication G5C61_RS18460 ENOG41089UC methyltransferase, type 11 G5C61_RS18465 ENOG4107SQ8 Glycine betaine G5C61_RS18470 ENOG4108IJ7 Glycine betaine G5C61_RS18490 ENOG4105C8Y Acetylornithine aminotransferase G5C61_RS18500 ENOG4105CUB amino acid G5C61_RS18505 ENOG4107YBY Hydrolase G5C61_RS18510 ENOG4105D01 (LipO)protein G5C61_RS18515 ENOG4108UMI ABC transporter, permease G5C61_RS18520 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS18530 ENOG4107T8P acyl-Coa dehydrogenase G5C61_RS18535 ENOG4105FBW Monooxygenase G5C61_RS18540 ENOG4107T8P acyl-Coa dehydrogenase G5C61_RS18545 ENOG4108HUF Transporter G5C61_RS18550 ENOG4105DQ5 transport system permease protein G5C61_RS18555 ENOG4108U1V ABC transporter, permease G5C61_RS18565 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G5C61_RS18580 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G5C61_RS18605 ENOG4105ETU transcriptional activator (TenA G5C61_RS18615 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G5C61_RS18630 ENOG41080HJ 6-phospho 3-hexuloisomerase G5C61_RS18635 ENOG4108VA3 3-hexulose-6-phosphate synthase G5C61_RS18640 ENOG4105KVH Transcriptional regulator G5C61_RS18675 ENOG4105ECB domain protein G5C61_RS18680 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G5C61_RS18685 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G5C61_RS18690 ENOG4105KVH Transcriptional regulator G5C61_RS18700 ENOG4105BZ1 (ABC) transporter G5C61_RS18705 ENOG4105BZ1 (ABC) transporter G5C61_RS18725 ENOG4105MI2 G5C61_RS18730 ENOG4107HP6 Transcriptional regulator G5C61_RS18740 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G5C61_RS18745 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS18750 ENOG4105CW7 secretion protein, HlyD family G5C61_RS18755 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS18760 ENOG4105CS1 NAD(P)H quinone oxidoreductase G5C61_RS18775 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS18785 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G5C61_RS18790 ENOG4105C2J ABC transporter G5C61_RS18795 ENOG4105CNN ABC, transporter G5C61_RS18800 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G5C61_RS18805 ENOG41069ER domain protein G5C61_RS18810 ENOG4107XC4 flavin reductase domain protein, FMN-binding G5C61_RS18850 ENOG4107QJZ Glycosyl transferase, family 2 G5C61_RS18860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS18865 ENOG4105BZU Histidine kinase G5C61_RS18885 ENOG4108JPW Aminotransferase G5C61_RS18900 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G5C61_RS18905 ENOG4105C7N Xanthine uracil vitamin C permease G5C61_RS18910 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS18915 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G5C61_RS18930 ENOG4105FF2 Type I DHQase G5C61_RS18945 ENOG4105C5Y PTS System G5C61_RS18950 ENOG4105CG3 alpha amylase, catalytic region G5C61_RS18955 ENOG4107414 GntR family transcriptional regulator G5C61_RS18960 ENOG4105P4J Allophanate hydrolase, subunit 1 G5C61_RS18970 ENOG4105E7W lamb ycsf family protein G5C61_RS18975 ENOG4105C5A transporter G5C61_RS18980 ENOG4108UT2 hemolysin iii G5C61_RS18995 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G5C61_RS19000 ENOG4106F5Q Membrane G5C61_RS19030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G5C61_RS19035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G5C61_RS19055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G5C61_RS19070 ENOG4105CUB amino acid G5C61_RS19075 ENOG4105DZC cytosine deaminase G5C61_RS19085 ENOG4105CJ1 ABC, transporter G5C61_RS19090 ENOG4105VEQ Cold shock protein G5C61_RS19095 ENOG4108RYK Nad-dependent epimerase dehydratase G5C61_RS19100 ENOG4105EE0 oxidoreductase G5C61_RS19105 ENOG4105D3R alkyl hydroperoxide reductase G5C61_RS19110 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G5C61_RS19135 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G5C61_RS19220 ENOG4105F32 YngK protein G5C61_RS19225 ENOG4106KNT transcriptional regulator G5C61_RS19245 ENOG4105F8D glycoside hydrolase family 4 G5C61_RS19255 ENOG4105VCP PTS System G5C61_RS19265 ENOG4105RD7 BadF BadG BcrA BcrD G5C61_RS19270 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G5C61_RS19275 ENOG4106ETB IIa component G5C61_RS19285 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G5C61_RS19300 ENOG4105E66 phosphoriboisomerase A G5C61_RS19315 ENOG4108VZI ErfK ybiS ycfS ynhG family protein G5C61_RS19320 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G5C61_RS19325 ENOG4108WAV Transcriptional regulator G5C61_RS19340 ENOG4105CPC Aldo Keto reductase G5C61_RS19355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G5C61_RS19365 ENOG4105CMR udp-glucose 4-epimerase G5C61_RS19410 ENOG4105BZU Histidine kinase G5C61_RS19415 ENOG4105BZU Histidine kinase G5C61_RS19420 ENOG4105KVH Transcriptional regulator G5C61_RS19425 ENOG4105CSC Glucose uptake protein G5C61_RS19430 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G5C61_RS19435 ENOG4105C09 Bile acid G5C61_RS19440 ENOG4106CAD Protein of unknown function (DUF3311) G5C61_RS19445 ENOG4105E1V na solute symporter G5C61_RS19480 ENOG4105JFG SpoIID LytB domain protein G5C61_RS19485 ENOG4105CV8 reductase G5C61_RS19505 ENOG4105DTQ mandelate racemase muconate lactonizing G5C61_RS19525 ENOG4108JPW Aminotransferase G5C61_RS19535 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS19555 ENOG41082BM Transcriptional regulator, arsr family G5C61_RS19585 ENOG4105BZU Histidine kinase G5C61_RS19590 ENOG4105EUJ GTP cyclohydrolase i G5C61_RS19595 ENOG4108JU3 Alkyl hydroperoxide reductase G5C61_RS19600 ENOG4105I03 Flagellin G5C61_RS19635 ENOG4107RVV histidinol phosphate phosphatase, hisj family G5C61_RS19640 ENOG4108IMY Transcriptional regulator G5C61_RS19660 ENOG4108RB3 Capsular polysaccharide biosynthesis protein G5C61_RS19665 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G5C61_RS19670 ENOG4105D3Q Sugar transferase G5C61_RS19675 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase G5C61_RS19685 ENOG4105ER6 polysaccharide biosynthesis protein G5C61_RS19700 ENOG4107RZX Teichoic acid biosynthesis protein G5C61_RS19720 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G5C61_RS19725 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G5C61_RS19735 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G5C61_RS19740 ENOG4105HTX biosynthesis protein G5C61_RS19745 ENOG4107YJ4 chain length determinant protein G5C61_RS19750 ENOG4108KGH TRANSCRIPTIONal G5C61_RS19760 ENOG4108RB3 Capsular polysaccharide biosynthesis protein G5C61_RS19780 ENOG4105CBC glutamate synthase G5C61_RS19790 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G5C61_RS19800 ENOG4105C6Z Gluconate G5C61_RS19820 ENOG4108IFG nitrite reductase, (NAD(P)H) G5C61_RS19825 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit G5C61_RS19830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G5C61_RS19835 ENOG4108QTI )-transporter G5C61_RS19845 ENOG4105D7K pfkb domain protein G5C61_RS19870 ENOG4107QJQ Mate efflux family protein G5C61_RS19880 ENOG4108KGH TRANSCRIPTIONal G5C61_RS19890 ENOG4105D7N magnesium and cobalt transport protein CorA G5C61_RS19895 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G5C61_RS19925 ENOG4108SU4 UPF0309 protein G5C61_RS19935 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G5C61_RS19940 ENOG4105CE4 GlcNAc 6-P deacetylase G5C61_RS19945 ENOG4105CI1 PTS System G5C61_RS19950 ENOG4108UQV Membrane G5C61_RS19985 ENOG4105CJ1 ABC, transporter G5C61_RS19990 ENOG4105C37 (CBS) domain G5C61_RS20005 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G5C61_RS20085 ENOG4105RHY Pfam:UPF0157 G5C61_RS20100 ENOG4105C7N Xanthine uracil vitamin C permease G5C61_RS20110 ENOG4107Y7X LytTR G5C61_RS20115 ENOG4108IUW ABC transporter G5C61_RS20120 ENOG4108SDH ABC, transporter G5C61_RS20140 ENOG4105E0X reductase G5C61_RS20145 ENOG4108B31 Spore germination protein G5C61_RS20160 ENOG4105G6Z alkaline phosphatase G5C61_RS20165 ENOG4105DY9 regulatoR G5C61_RS20170 ENOG4105BZU Histidine kinase G5C61_RS20175 ENOG4107TS3 membrane protein, TerC G5C61_RS20180 ENOG4108WZW RNA polymerase sigma G5C61_RS20185 ENOG410681C small acid-soluble spore protein G5C61_RS20205 ENOG4105CHR reductase G5C61_RS20235 ENOG4105JXH GntR family transcriptional regulator G5C61_RS20240 ENOG4105DAP Nicotinate phosphoribosyltransferase G5C61_RS20245 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G5C61_RS20250 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G5C61_RS20255 ENOG4107QR9 Iron-sulfur cluster binding protein G5C61_RS20260 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) G5C61_RS20265 ENOG4105BZU Histidine kinase G5C61_RS20270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G5C61_RS20280 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G5C61_RS20285 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) G5C61_RS20290 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G5C61_RS20300 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate G5C61_RS20305 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) G5C61_RS20310 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) G5C61_RS20315 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G5C61_RS20325 ENOG4105C2J ABC transporter G5C61_RS20330 ENOG4105CNN ABC, transporter G5C61_RS20355 ENOG41090MY MarR family Transcriptional regulator G5C61_RS20365 ENOG4105BZU Histidine kinase G5C61_RS20380 ENOG4105DFD Na H antiporter G5C61_RS20395 ENOG4105E1K spore germination protein G5C61_RS20415 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G5C61_RS20420 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase G5C61_RS20425 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G5C61_RS20430 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G5C61_RS20435 ENOG4105K4T epimerase G5C61_RS20465 ENOG4105F0V Cell wall hydrolase G5C61_RS20515 ENOG4108K88 Membrane G5C61_RS20525 ENOG4108R6K riboflavin synthase, subunit alpha G5C61_RS20535 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G5C61_RS20545 ENOG4105CID antiterminator G5C61_RS20555 ENOG4105KRI phosphocarrier protein (HPr G5C61_RS20560 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G5C61_RS20565 ENOG41067MG lrgb family G5C61_RS20570 ENOG4105VAW lrga family G5C61_RS20575 ENOG4105CMU LysR family (Transcriptional regulator G5C61_RS20590 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G5C61_RS20600 ENOG4105CHM Aminotransferase G5C61_RS20620 ENOG4107R88 Chemotaxis protein (CheV) G5C61_RS20625 ENOG4105UIN G5C61_RS20630 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein G5C61_RS20640 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G5C61_RS20655 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G5C61_RS20660 ENOG4105EPM Diguanylate phosphodiesterase G5C61_RS20675 ENOG4107IN1 Protein of unknown function (DUF1797) G5C61_RS20690 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G5C61_RS20695 ENOG4105CH2 amidohydrolase G5C61_RS20705 ENOG4105D8X mechanosensitive ion channel G5C61_RS20710 ENOG4105D3R alkyl hydroperoxide reductase G5C61_RS20715 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G5C61_RS20725 ENOG4105BZ1 (ABC) transporter G5C61_RS20730 ENOG4105BZ1 (ABC) transporter G5C61_RS20735 ENOG4107ZYR domain protein G5C61_RS20740 ENOG4105CN5 Metallo-Beta-Lactamase G5C61_RS20745 ENOG4106EHS UPF0356 protein G5C61_RS20750 ENOG4108X4Q Hydrolase G5C61_RS20775 ENOG4105CPP Dehydrogenase, E1 component G5C61_RS20780 ENOG4105C7S Dehydrogenase G5C61_RS20795 ENOG4105C94 Transporter G5C61_RS20805 ENOG4105CXN decarboxylase G5C61_RS20810 ENOG4105WBI UPF0223 protein G5C61_RS20825 ENOG4105ECY inositol monophosphatase G5C61_RS20835 ENOG4105CI3 gtp-binding protein typa G5C61_RS20840 ENOG4105QA2 G5C61_RS20865 ENOG4108IAB Phoh family G5C61_RS20880 ENOG4105CNI cell division protein FtsW G5C61_RS20885 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G5C61_RS20890 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) G5C61_RS20895 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G5C61_RS20935 ENOG41080XQ Signal transduction protein with cbs domains G5C61_RS20940 ENOG4106UY4 Inherit from COG: Scp-like extracellular G5C61_RS20955 ENOG4108JYZ YitT family G5C61_RS20960 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase G5C61_RS20965 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G5C61_RS20970 ENOG4108Z5K methylglyoxal synthase G5C61_RS20975 ENOG4105FJR Lmbe family G5C61_RS20980 ENOG4105CPK Glycosyl transferase (Group 1 G5C61_RS20985 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G5C61_RS20990 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G5C61_RS21000 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G5C61_RS21005 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G5C61_RS21010 ENOG4105DVT helicase G5C61_RS21020 ENOG4105YAC G5C61_RS21030 ENOG4105CHM Aminotransferase G5C61_RS21045 ENOG4105CSM endonuclease III G5C61_RS21055 ENOG4105BZ4 penicillin-binding protein G5C61_RS21110 ENOG4106UIA G5C61_RS21120 ENOG4105C28 cystathionine G5C61_RS21125 ENOG4105C28 cystathionine G5C61_RS21140 ENOG4105CK7 Sodium proline symporter G5C61_RS21170 ENOG4105BZU Histidine kinase G5C61_RS21180 ENOG4108I5C dEAD DEAH box helicase G5C61_RS21185 ENOG4107X2U Inherit from COG: Exonuclease-like protein G5C61_RS21195 ENOG4106F55 Protein of unknown function (DUF1273) G5C61_RS21200 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) G5C61_RS21225 ENOG4105ENE Histidine kinase G5C61_RS21230 ENOG4105WH1 Two component transcriptional regulator luxr family G5C61_RS21240 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G5C61_RS21255 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G5C61_RS21275 ENOG4105DVT helicase G5C61_RS21280 ENOG4105CTD carboxy-peptidase G5C61_RS21285 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) G5C61_RS21290 ENOG4105C2W permease G5C61_RS21295 ENOG4105F04 LysR family Transcriptional regulator G5C61_RS21300 ENOG4105C26 Dehydrogenase G5C61_RS21310 ENOG41065KQ synthase G5C61_RS21320 ENOG410890F Dynamin family G5C61_RS21325 ENOG410756H nucleotidyltransferase G5C61_RS21350 ENOG41081VK Ribonuclease G5C61_RS21395 ENOG4108ME1 Peptidase M55 D-aminopeptidase G5C61_RS21400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS21405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS21410 ENOG4105C3U ABC transporter G5C61_RS21420 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G5C61_RS21425 ENOG4107SN7 NLP P60 protein G5C61_RS21430 ENOG4108JQ7 (ABC) transporter G5C61_RS21445 ENOG4105KNA -acetyltransferase G5C61_RS21450 ENOG4105BZU Histidine kinase G5C61_RS21465 ENOG4108HUF Transporter G5C61_RS21470 ENOG4105DQ5 transport system permease protein G5C61_RS21475 ENOG4108U1V ABC transporter, permease G5C61_RS21480 ENOG4105E0A ABC, transporter G5C61_RS21505 ENOG4108S01 response regulator G5C61_RS21510 ENOG4108ZGX Histidine kinase G5C61_RS21515 ENOG4105ECK Fatty Acid Desaturase G5C61_RS21525 ENOG4105IIP Membrane G5C61_RS21530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G5C61_RS21535 ENOG4108TM9 integral membrane protein G5C61_RS21545 ENOG4105K4H Nlp p60 protein G5C61_RS21550 ENOG41087PP glycosyltransferase MGT family G5C61_RS21555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G5C61_RS21575 ENOG4105CHR reductase G5C61_RS21580 ENOG41069H0 dihydroorotase EC 3.5.2.3 G5C61_RS21600 ENOG4105FDP GntR family transcriptional regulator G5C61_RS21605 ENOG4105C6Z Gluconate G5C61_RS21610 ENOG4106P19 photosystem i assembly btpa G5C61_RS21620 ENOG4105G6Z alkaline phosphatase G5C61_RS21625 ENOG4107ZXU DSBA oxidoreductase G5C61_RS21640 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS21645 ENOG4105CW7 secretion protein, HlyD family G5C61_RS21650 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS21675 ENOG4105EHG Permease protein G5C61_RS21680 ENOG4105DQ5 transport system permease protein G5C61_RS21690 ENOG4105E0A ABC, transporter G5C61_RS21700 ENOG4105C28 cystathionine G5C61_RS21705 ENOG4105C2C drug resistance transporter, Bcr CflA G5C61_RS21720 ENOG4105ENE Histidine kinase G5C61_RS21725 ENOG4108VB1 regulatoR G5C61_RS21730 ENOG4105EYF MMPL domain protein G5C61_RS21750 ENOG4105C5H ABC transporter G5C61_RS21765 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G5C61_RS21785 ENOG4105GZI Transcriptional regulator G5C61_RS21795 ENOG4108RWP Major Facilitator Superfamily protein G5C61_RS21800 ENOG4108VZI ErfK ybiS ycfS ynhG family protein G5C61_RS21820 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G5C61_RS21825 ENOG4105KVH Transcriptional regulator G5C61_RS21830 ENOG4108VA3 3-hexulose-6-phosphate synthase G5C61_RS21840 ENOG4105F76 Sarcosine oxidase G5C61_RS21845 ENOG4105DVW rieske (2Fe-2S) G5C61_RS21850 ENOG4108IJ7 Glycine betaine G5C61_RS21865 ENOG4105CA9 Pyruvate kinase G5C61_RS21875 ENOG4105BZU Histidine kinase G5C61_RS21880 ENOG4108MJI response regulator G5C61_RS21890 ENOG4105CUB amino acid G5C61_RS21905 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G5C61_RS21910 ENOG4105EDQ levansucrase EC 2.4.1.10 G5C61_RS21915 ENOG4108HKT sucrose-6-phosphate hydrolase G5C61_RS21920 ENOG4108UQY Iron-storage protein G5C61_RS21925 ENOG4105C0R drug resistance transporter emrb qaca subfamily G5C61_RS21935 ENOG4105EXW epimerase dehydratase G5C61_RS21940 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) G5C61_RS21945 ENOG4107RGD Major Facilitator superfamily G5C61_RS21960 ENOG4105C26 Dehydrogenase G5C61_RS21995 ENOG4105CN5 Metallo-Beta-Lactamase G5C61_RS22040 ENOG4105YWU small acid-soluble spore protein G5C61_RS22045 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS22050 ENOG4105CNG UPF0061 protein G5C61_RS22055 ENOG4105EDQ levansucrase EC 2.4.1.10 G5C61_RS22060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G5C61_RS22065 ENOG4105YHU PTS system G5C61_RS22070 ENOG4108IQ3 PTS system G5C61_RS22075 ENOG4105ETZ PTS System G5C61_RS22080 ENOG4105F3R pts system mannose fructose sorbose family iid G5C61_RS22085 ENOG4108HKT sucrose-6-phosphate hydrolase G5C61_RS22105 ENOG4105D01 (LipO)protein G5C61_RS22110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS22115 ENOG4108UMI ABC transporter, permease G5C61_RS22130 ENOG4107T8P acyl-Coa dehydrogenase G5C61_RS22135 ENOG4105D01 (LipO)protein G5C61_RS22140 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G5C61_RS22145 ENOG4108UMI ABC transporter, permease G5C61_RS22160 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) G5C61_RS22170 ENOG4108UIN ybak prolyl-trna synthetase associated region G5C61_RS22185 ENOG4105C84 Histidine ammonia-lyase G5C61_RS22195 ENOG4105CI2 imidazolone-5-propionate hydrolase G5C61_RS22200 ENOG4108903 Formimidoylglutamase G5C61_RS22205 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G5C61_RS22220 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G5C61_RS22230 ENOG4105DYB Isoaspartyl dipeptidase G5C61_RS22255 ENOG4105VUF Transcriptional regulator G5C61_RS22265 ENOG4105KNA -acetyltransferase G5C61_RS22285 ENOG4108U05 Transcriptional regulator G5C61_RS22290 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 G5C61_RS22325 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 G5C61_RS22335 ENOG4105MKU Transcriptional regulator G5C61_RS22345 ENOG4105CV1 Transketolase (EC 2.2.1.1) G5C61_RS22350 ENOG4108IUS Transketolase G5C61_RS22360 ENOG41073TP transcriptional regulator G5C61_RS22380 ENOG4108YZG isomerase G5C61_RS22385 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G5C61_RS22435 ENOG4107V2S Transcriptional regulator G5C61_RS22455 ENOG4108PSK reductase G5C61_RS22475 ENOG4107ZTW SNARE associated Golgi G5C61_RS22500 ENOG4105E1K spore germination protein G5C61_RS22505 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF G5C61_RS22525 ENOG4105C0A alcohol dehydrogenase G5C61_RS22535 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS22545 ENOG4105CY2 Citrate transporter G5C61_RS22550 ENOG4105CHR reductase G5C61_RS22555 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G5C61_RS22560 ENOG4107RT3 EamA-like transporter family G5C61_RS22565 ENOG4105GZI Transcriptional regulator G5C61_RS22570 ENOG4105EYF MMPL domain protein G5C61_RS22580 ENOG4107TS3 membrane protein, TerC G5C61_RS22615 ENOG4105XDF Protein of unknown function (DUF1272) G5C61_RS22640 ENOG4105KPY Small multidrug resistance protein G5C61_RS22660 ENOG4105VEQ Cold shock protein G5C61_RS22670 ENOG4105C1J atp-dependent rna helicase G5C61_RS22675 ENOG4105VEQ Cold shock protein G5C61_RS22725 ENOG4106GRI small acid-soluble spore protein H G5C61_RS22745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G5C61_RS22750 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G5C61_RS22755 ENOG41080XP Cbs domain G5C61_RS22795 ENOG41080XP Cbs domain G5C61_RS22825 ENOG4105DJ2 Major Facilitator Superfamily G5C61_RS22855 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G5C61_RS22860 ENOG4107U9B transcriptional regulator G5C61_RS22865 ENOG4105DXI Major Facilitator superfamily G5C61_RS22875 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein G5C61_RS22880 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G5C61_RS22900 ENOG4108I0C methyltransferase G5C61_RS22905 ENOG4105VUF Transcriptional regulator G5C61_RS22910 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G5C61_RS22920 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G5C61_RS22935 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G5C61_RS22940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G5C61_RS22945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G5C61_RS22955 ENOG4108JQ7 (ABC) transporter G5C61_RS22960 ENOG4107R73 Mate efflux family protein G5C61_RS22965 ENOG4108MK9 spermidine N(1)-acetyltransferase G5C61_RS22985 ENOG4105CZN Potassium uptake protein G5C61_RS22990 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) G5C61_RS22995 ENOG4108T5E Copper resistance protein G5C61_RS23000 ENOG4105KTB nuclear export factor GLE1 G5C61_RS23010 ENOG4108PJD permease G5C61_RS23020 ENOG4108PJD permease G5C61_RS23025 ENOG4105DSE periplasmic solute binding protein G5C61_RS23030 ENOG4105DIK (ABC) transporter G5C61_RS23040 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) G5C61_RS23065 ENOG4105D06 uba thif-type nad fad binding protein G5C61_RS23105 ENOG4105D5G Transposase G5C61_RS23110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS23125 ENOG4105KME endoribonuclease L-psp G5C61_RS23135 ENOG4105C2C drug resistance transporter, Bcr CflA G5C61_RS23145 ENOG4106SCS STAS domain G5C61_RS23160 ENOG4105CPC Aldo Keto reductase G5C61_RS23170 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G5C61_RS23175 ENOG4105ST3 Transcriptional regulator G5C61_RS23190 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G5C61_RS23195 ENOG4105C2C drug resistance transporter, Bcr CflA G5C61_RS23210 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS23220 ENOG4105DCM major facilitator superfamily G5C61_RS23230 ENOG4105JAB phenazine biosynthesis protein, phzf family G5C61_RS23255 ENOG4105ST3 Transcriptional regulator G5C61_RS23265 ENOG4105C3M thioredoxin reductase G5C61_RS23290 ENOG41080V3 Major Facilitator superfamily G5C61_RS23310 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G5C61_RS23355 ENOG4105C59 p-type ATPase G5C61_RS23380 ENOG4108UZ3 Transporter G5C61_RS23385 ENOG4108SXZ UPF0302 protein G5C61_RS23390 ENOG4105KVH Transcriptional regulator G5C61_RS23400 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G5C61_RS23405 ENOG4108R6W Transcriptional regulator, ARAC family G5C61_RS23415 ENOG4105CMT Dihydroxyacetone kinase G5C61_RS23425 ENOG4108IJ0 Aspartate ammonia-lyase G5C61_RS23470 ENOG4105VEQ Cold shock protein G5C61_RS23490 ENOG4105CNI cell division protein FtsW G5C61_RS23515 ENOG4105E2A Dehydrogenase G5C61_RS23520 ENOG4105PGS Spore coat protein G5C61_RS23535 ENOG4105BZU Histidine kinase G5C61_RS23540 ENOG4108NEV two component transcriptional regulator, LytTR family G5C61_RS23545 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS23560 ENOG4105CIB oxidoreductase Domain protein G5C61_RS23565 ENOG4107QP6 Xylose isomerase domain protein TIM barrel G5C61_RS23570 ENOG4105IE8 Alpha-ketoglutarate permease G5C61_RS23590 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G5C61_RS23650 ENOG4105DYS nad(p)h dehydrogenase (quinone) G5C61_RS23725 ENOG4105E1F short-chain dehydrogenase reductase G5C61_RS23735 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G5C61_RS23740 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G5C61_RS23745 ENOG4105C54 Major Facilitator superfamily G5C61_RS23750 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS23760 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G5C61_RS23765 ENOG4105DRS transport system, permease G5C61_RS23775 ENOG4108HKT sucrose-6-phosphate hydrolase G5C61_RS23780 ENOG4105D7K pfkb domain protein G5C61_RS23785 ENOG4108UW5 maltose o-acetyltransferase G5C61_RS23800 ENOG4107Z3H Transcriptional regulator, TetR family G5C61_RS23815 ENOG4108W6C Dehydrogenase G5C61_RS23820 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G5C61_RS23830 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G5C61_RS23835 ENOG4107QNK )-transporter G5C61_RS23840 ENOG4105ETE Transcriptional regulator (LacI family G5C61_RS23850 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G5C61_RS23865 ENOG4105CPC Aldo Keto reductase G5C61_RS23870 ENOG4105CF7 AraC family transcriptional regulator G5C61_RS23885 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G5C61_RS23900 ENOG4108Z66 YbaK ebsC protein G5C61_RS23915 ENOG4105BZU Histidine kinase G5C61_RS23920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G5C61_RS23930 ENOG4105CSH Transporter G5C61_RS23955 ENOG4105C26 Dehydrogenase G5C61_RS23985 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G5C61_RS23990 ENOG41080XP Cbs domain G5C61_RS24005 ENOG4105DG4 malate L-lactate dehydrogenase G5C61_RS24010 ENOG4105CPQ Dehydrogenase G5C61_RS24015 ENOG4108UHU Aldolase G5C61_RS24020 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) G5C61_RS24025 ENOG4105DMW Dehydrogenase reductase G5C61_RS24035 ENOG4108I5G Major Facilitator superfamily G5C61_RS24040 ENOG4105UEI Transcriptional Regulator AraC Family G5C61_RS24045 ENOG4105CTX dehydratase G5C61_RS24050 ENOG4105CPQ Dehydrogenase G5C61_RS24055 ENOG4107QZW Altronate oxidoreductase G5C61_RS24065 ENOG4105YA8 Transcriptional regulator G5C61_RS24080 ENOG4105CMG Carbohydrate kinase G5C61_RS24085 ENOG4107QNK )-transporter G5C61_RS24090 ENOG4108JUB Transcriptional regulator G5C61_RS24095 ENOG4105D4T Citrate transporter G5C61_RS24120 ENOG4107YZX Universal stress protein G5C61_RS24125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G5C61_RS24130 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) G5C61_RS24135 ENOG4105E1J oxidoreductase G5C61_RS24150 ENOG4105C7N Xanthine uracil vitamin C permease G5C61_RS24160 ENOG4107RUY (E1 component), alpha subunit G5C61_RS24170 ENOG4107QKR Dehydrogenase G5C61_RS24180 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G5C61_RS24190 ENOG4105C28 cystathionine G5C61_RS24210 ENOG4105CTX dehydratase G5C61_RS24220 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G5C61_RS24225 ENOG4105C26 Dehydrogenase G5C61_RS24230 ENOG4105DJB Major Facilitator Superfamily G5C61_RS24235 ENOG4105EQX glucarate dehydratase G5C61_RS24240 ENOG41073TP transcriptional regulator G5C61_RS24260 ENOG4105C02 permease G5C61_RS24265 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G5C61_RS24280 ENOG4105CT4 transporter G5C61_RS24295 ENOG4107YZX Universal stress protein G5C61_RS24300 ENOG4105BZU Histidine kinase G5C61_RS24310 ENOG4105VPX protein, conserved in bacteria G5C61_RS24315 ENOG410681U heavy metal transport detoxification protein G5C61_RS24320 ENOG4105C59 p-type ATPase G5C61_RS24330 ENOG41090UD (LipO)protein G5C61_RS24365 ENOG41082YX Transcriptional regulator, arsr family G5C61_RS24370 ENOG4107R5R arsenical pump membrane protein G5C61_RS24380 ENOG4108VUY thioesterase Superfamily protein G5C61_RS24385 ENOG41081VB Hydrolase G5C61_RS24390 ENOG4108QY0 Membrane G5C61_RS24405 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G5C61_RS24410 ENOG4105DRR Transcriptional regulator, GntR family G5C61_RS24415 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G5C61_RS24420 ENOG4105CZM Major Facilitator G5C61_RS24425 ENOG4105KVH Transcriptional regulator G5C61_RS24430 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G5C61_RS24460 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G5C61_RS24470 ENOG4105X5K response regulator receiver protein G5C61_RS24480 ENOG4105KHC sulfurtransferase G5C61_RS24535 ENOG4105CVG Homoserine O-transsuccinylase G5C61_RS24550 ENOG4108V06 Glutathione peroxidase G5C61_RS24560 ENOG4105C5H ABC transporter G5C61_RS24570 ENOG4108ZJ4 polysaccharide deacetylase G5C61_RS24575 ENOG4108Y6J UPF0403 protein G5C61_RS24580 ENOG4107YX5 Pfam:DUF548 G5C61_RS24590 ENOG4105SZ6 Thioredoxin G5C61_RS24595 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G5C61_RS24605 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G5C61_RS24610 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G5C61_RS24615 ENOG4108YZT Adenosylcobinamide kinase G5C61_RS24620 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G5C61_RS24625 ENOG4105CVJ phosphoglycerate mutase G5C61_RS24635 ENOG4108WBT adenosyltransferase G5C61_RS24640 ENOG4105FR1 rard protein G5C61_RS24655 ENOG4105CKI cobalamin synthesis protein G5C61_RS24660 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G5C61_RS24665 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G5C61_RS24690 ENOG4105II7 pyrroline-5-carboxylate reductase G5C61_RS24695 ENOG4105KIR Thiol-disulfide oxidoreductase dcc G5C61_RS24715 ENOG4105KRN Transcriptional regulator, abrb family G5C61_RS24720 ENOG4107QMU Mate efflux family protein G5C61_RS24725 ENOG4105CHR reductase G5C61_RS24760 ENOG4105CDW Resistance protein G5C61_RS24795 ENOG4105BZU Histidine kinase G5C61_RS24805 ENOG4107R6U sodium dicarboxylate symporter G5C61_RS24810 ENOG4108IUM Glycogen debranching enzyme G5C61_RS24815 ENOG4105C26 Dehydrogenase G5C61_RS24820 ENOG41068W2 Cytochrome p-450 G5C61_RS24840 ENOG4105E14 MotA TolQ exbB proton channel G5C61_RS24845 ENOG4105ER2 Ompa motb domain protein G5C61_RS24860 ENOG4108NA0 Uncharacterized conserved protein (COG2071) G5C61_RS24865 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G5C61_RS24870 ENOG4105DFD Na H antiporter G5C61_RS24885 ENOG4108TGC Acyltransferase G5C61_RS24890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G5C61_RS24900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS24905 ENOG4105US7 Histidine kinase G5C61_RS24910 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) G5C61_RS24915 ENOG4105DUX Transporter G5C61_RS24925 ENOG4105C6K Malic enzyme G5C61_RS24935 ENOG410667J hydrolase G5C61_RS24940 ENOG4105DEN Luciferase family G5C61_RS24975 ENOG4105CDA abc transporter atp-binding protein G5C61_RS24995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G5C61_RS25035 ENOG4108URH decarboxylase G5C61_RS25045 ENOG410905X membrane-flanked domain protein G5C61_RS25050 ENOG4105CKV Membrane G5C61_RS25065 ENOG4105D7K pfkb domain protein G5C61_RS25070 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G5C61_RS25075 ENOG4105K7W phage-related replication protein G5C61_RS25090 ENOG4107SWG transcriptional regulator MERR family G5C61_RS25115 ENOG41069DP small acid-soluble spore protein G5C61_RS25120 ENOG4108R1P G5C61_RS25125 ENOG4105C5Q Transcriptional regulator G5C61_RS25130 ENOG4105CBC glutamate synthase G5C61_RS25135 ENOG4105BZ8 glutamate synthase G5C61_RS25155 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G5C61_RS25170 ENOG4107RZC phospholipase d G5C61_RS25180 ENOG41061AU MarR family Transcriptional regulator G5C61_RS25190 ENOG41067MG lrgb family G5C61_RS25210 ENOG4105EDW glycosyl transferase, family 39 G5C61_RS25215 ENOG4105CKK Glycosyl transferase, family 2 G5C61_RS25225 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G5C61_RS25230 ENOG4105EFI regulatoR G5C61_RS25255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G5C61_RS25280 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) G5C61_RS25295 ENOG4105E98 transcriptional regulator DeoR family G5C61_RS25300 ENOG4105DE4 1-phosphofructokinase G5C61_RS25305 ENOG4105DM4 PTS System G5C61_RS25310 ENOG4105CFH Aspartokinase G5C61_RS25320 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G5C61_RS25335 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G5C61_RS25340 ENOG41082YX Transcriptional regulator, arsr family G5C61_RS25345 ENOG4105C26 Dehydrogenase G5C61_RS25350 ENOG4105ETU transcriptional activator (TenA G5C61_RS25365 ENOG4105C8J )-transporter G5C61_RS25370 ENOG4105F0V Cell wall hydrolase G5C61_RS25390 ENOG4105CK5 oxidoreductase G5C61_RS25395 ENOG4107QP6 Xylose isomerase domain protein TIM barrel G5C61_RS25400 ENOG4108VX5 3-methyladenine DNA glycosylase G5C61_RS25405 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G5C61_RS25415 ENOG4105I4A GCN5-related N-acetyltransferase G5C61_RS25420 ENOG41062JF Transcriptional regulator G5C61_RS25440 ENOG410606W general stress protein G5C61_RS25475 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G5C61_RS25480 ENOG4107T89 von Willebrand factor, type A G5C61_RS25485 ENOG4108UZ3 Transporter G5C61_RS25495 ENOG41075H3 AraC family transcriptional regulator G5C61_RS25505 ENOG4108428 Inherit from COG: -acetyltransferase G5C61_RS25510 ENOG4105DKW ABC transporter G5C61_RS25525 ENOG4105EWU Squalene--hopene cyclase G5C61_RS25535 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G5C61_RS25545 ENOG4105JAB phenazine biosynthesis protein, phzf family G5C61_RS25560 ENOG4108NGU Transcriptional regulator G5C61_RS25565 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G5C61_RS25570 ENOG4105EMU Dehydrogenase G5C61_RS25595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS25600 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G5C61_RS25645 ENOG4107YJ4 chain length determinant protein G5C61_RS25660 ENOG4108PQP glycosyl transferase group 1 G5C61_RS25665 ENOG4108KMV Glycosyl transferase (Group 1 G5C61_RS25670 ENOG4108SHN Glycosyl transferase, family 2 G5C61_RS25675 ENOG41068W6 Capsular polysaccharide biosynthesis protein G5C61_RS25680 ENOG4105CMR udp-glucose 4-epimerase G5C61_RS25690 ENOG4105D3Q Sugar transferase G5C61_RS25695 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family G5C61_RS25700 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G5C61_RS25705 ENOG4108IMY Transcriptional regulator G5C61_RS25725 ENOG4105CPK Glycosyl transferase (Group 1 G5C61_RS25790 ENOG4105BZ1 (ABC) transporter G5C61_RS25815 ENOG4105BZ1 (ABC) transporter G5C61_RS25825 ENOG4105DIN metallophosphoesterase G5C61_RS25840 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G5C61_RS25850 ENOG4105DAP Nicotinate phosphoribosyltransferase G5C61_RS25855 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G5C61_RS25860 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G5C61_RS25865 ENOG41060GV RNA binding s1 domain protein G5C61_RS25870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin G5C61_RS25875 ENOG4105DTD Dehydrogenase G5C61_RS25880 ENOG410855V Acylphosphatase G5C61_RS25885 ENOG4105EU0 Major facilitator Superfamily G5C61_RS25890 ENOG4105DEN Luciferase family G5C61_RS25900 ENOG4105FTV AraC Family Transcriptional Regulator G5C61_RS25905 ENOG4108RNG Permease of the drug metabolite transporter G5C61_RS25910 ENOG4105C5H ABC transporter G5C61_RS25920 ENOG4108Q8B Spore germination protein G5C61_RS25925 ENOG4108NHD germination protein G5C61_RS25930 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ G5C61_RS25935 ENOG4105CJ1 ABC, transporter G5C61_RS25945 ENOG4107S6Z Na H antiporter G5C61_RS25960 ENOG4105F6S Spore photoproduct lyase G5C61_RS25980 ENOG4105C9U ATP-dependent DNA helicase RecQ G5C61_RS25990 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase G5C61_RS26010 ENOG4107RZC phospholipase d G5C61_RS26030 ENOG4107S6Z Na H antiporter G5C61_RS26060 ENOG41073R8 VanW family G5C61_RS26100 ENOG4105C9U ATP-dependent DNA helicase RecQ G5C61_RS26130 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G5C61_RS26145 ENOG4105KWG Pfam:DUF1696 G5C61_RS26150 ENOG4105D94 Major Facilitator Superfamily G5C61_RS26155 ENOG4105DUM transcriptional regulator, lysR family G5C61_RS26160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G5C61_RS26165 ENOG4105DVE abc transporter atp-binding protein G5C61_RS26175 ENOG4105EMN RNA polymerase sigma factor G5C61_RS26190 ENOG4108ZHJ Organic hydroperoxide resistance protein G5C61_RS26195 ENOG4105K56 Transcriptional regulator G5C61_RS26210 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) G5C61_RS26220 ENOG41069ER domain protein G5C61_RS26240 ENOG4105BZU Histidine kinase G5C61_RS26245 ENOG4105II7 pyrroline-5-carboxylate reductase G5C61_RS26250 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G5C61_RS26255 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G5C61_RS26270 ENOG4105JSC dimethylmenaquinone methyltransferase G5C61_RS26285 ENOG4108I9W Membrane G5C61_RS26290 ENOG4107TUM Amidinotransferase G5C61_RS26300 ENOG4107U9T Pfam:Ribonuclease_BN G5C61_RS26400 ENOG4108UW5 maltose o-acetyltransferase G5C61_RS26415 ENOG4106SCS STAS domain G5C61_RS26420 ENOG4106CAD Protein of unknown function (DUF3311) G5C61_RS26425 ENOG4105E1V na solute symporter G5C61_RS26435 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) G5C61_RS26450 ENOG4105C9Q fumarate hydratase class II G5C61_RS26460 ENOG4107YXZ hydrolase, family 25 G5C61_RS26470 ENOG4105BZU Histidine kinase G5C61_RS26510 ENOG4108RCM Nitroreductase G5C61_RS26520 ENOG4108IXY short-chain dehydrogenase reductase G5C61_RS26525 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G5C61_RS26530 ENOG4108V9W transcriptional regulatory protein G5C61_RS26535 ENOG4105D4T Citrate transporter G5C61_RS26545 ENOG4105CY2 Citrate transporter G5C61_RS26550 ENOG4105DTD Dehydrogenase G5C61_RS26555 ENOG4105CIN aminoacyl-histidine dipeptidase G5C61_RS26585 ENOG4105CMU LysR family (Transcriptional regulator G5C61_RS26595 ENOG4105CK2 sodium dicarboxylate symporter G5C61_RS26600 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G5C61_RS26610 ENOG4107VFR oxidoreductase G5C61_RS26620 ENOG4105BZU Histidine kinase G5C61_RS26635 ENOG4105CHR reductase G5C61_RS26640 ENOG4105CEY Amp-dependent synthetase and ligase G5C61_RS26655 ENOG4105E39 Enoyl-CoA hydratase G5C61_RS26670 ENOG4108N5B 2-phosphosulfolactate phosphatase G5C61_RS26675 ENOG4105C1G acyl-Coa dehydrogenase G5C61_RS26680 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G5C61_RS26685 ENOG4105CGU Enoyl-CoA hydratase G5C61_RS26690 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G5C61_RS26695 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G5C61_RS26710 ENOG4105D6N CoA-transferase, subunit a G5C61_RS26715 ENOG4107QNJ CoA-transferase subunit B G5C61_RS26720 ENOG4105CHU acetyl-coa acetyltransferase G5C61_RS26725 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G5C61_RS26730 ENOG4108JPW Aminotransferase G5C61_RS26750 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G5C61_RS26760 ENOG4108IQI permease G5C61_RS26765 ENOG4106XGU G5C61_RS26770 ENOG4105KD7 acetyltransferase G5C61_RS26800 ENOG4105CPF Cell wall formation (By similarity) G5C61_RS26810 ENOG4108594 Permease of the drug metabolite transporter G5C61_RS26820 ENOG4105JKW Valine--pyruvate aminotransferase G5C61_RS26830 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G5C61_RS26835 ENOG4105F0V Cell wall hydrolase G5C61_RS26840 ENOG4105CBG Sulfatase G5C61_RS26855 ENOG4105CUB amino acid G5C61_RS26860 ENOG4105F27 Major Facilitator G5C61_RS26865 ENOG41062A4 Transcriptional regulator G5C61_RS26870 ENOG4105EYF MMPL domain protein G5C61_RS26885 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine G5C61_RS26890 ENOG4105XN3 extracellular solute-binding protein family 1 G5C61_RS26895 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G5C61_RS26900 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G5C61_RS26905 ENOG4108KPW sugar kinase G5C61_RS26910 ENOG4105FDP GntR family transcriptional regulator G5C61_RS26915 ENOG4105BZU Histidine kinase G5C61_RS26925 ENOG41082BM Transcriptional regulator, arsr family G5C61_RS26935 ENOG4107YUH hydrolase G5C61_RS26945 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G5C61_RS26960 ENOG4105NX3 Membrane G5C61_RS26970 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G5C61_RS26975 ENOG4108JQ1 Dehydrogenase G5C61_RS27005 ENOG4107YXZ hydrolase, family 25 G5C61_RS27015 ENOG4107Y9U Membrane G5C61_RS27035 ENOG4105WS7 Cation transport regulator G5C61_RS27040 ENOG4105EUZ Beta-lactamase domain protein G5C61_RS27050 ENOG4105D82 Glutamate dehydrogenase G5C61_RS27060 ENOG4107P26 G5C61_RS27135 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G5C61_RS27140 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G5C61_RS27150 ENOG4105P8F nudix hydrolase G5C61_RS27165 ENOG41067TZ transcriptional regulator, MarR family G5C61_RS27170 ENOG41073R8 VanW family G5C61_RS27175 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G5C61_RS27200 ENOG4105CVK Glutamate decarboxylase G5C61_RS27230 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) G5C61_RS27250 ENOG4105IQ5 FAD linked oxidase domain protein G5C61_RS27260 ENOG4105C8Q Methyl-accepting chemotaxis G5C61_RS27270 ENOG4108RE9 Phosphodiesterase G5C61_RS27280 ENOG4105DIN metallophosphoesterase G5C61_RS27285 ENOG4108VCA G U mismatch-specific DNA glycosylase G5C61_RS27295 ENOG4105EXQ uroporphyrinogen iii synthase hem4 G5C61_RS27300 ENOG4107258 Transcriptional regulator G5C61_RS27305 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G5C61_RS27320 ENOG4105P4J Allophanate hydrolase, subunit 1 G5C61_RS27325 ENOG4105CFM UPF0317 protein G5C61_RS27330 ENOG4105C5A transporter G5C61_RS27335 ENOG4105E7W lamb ycsf family protein G5C61_RS27340 ENOG4105CG3 alpha amylase, catalytic region G5C61_RS27385 ENOG4107F3J Amp-dependent synthetase and ligase G5C61_RS27390 ENOG4107ZYJ bioY protein G5C61_RS27400 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) G5C61_RS27420 ENOG4105WH1 Two component transcriptional regulator luxr family G5C61_RS27425 ENOG4105BZU Histidine kinase G5C61_RS27450 ENOG4107PBV potassium channel G5C61_RS27465 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase G5C61_RS27470 ENOG4106UW1 Major Facilitator superfamily G5C61_RS27475 ENOG4108HCJ Hydrolase G5C61_RS27480 ENOG4105F8D glycoside hydrolase family 4 G5C61_RS27490 ENOG4105CID antiterminator G5C61_RS27495 ENOG4105C5Y PTS System G5C61_RS27500 ENOG4105CS2 ec 3.2.1.21 G5C61_RS27510 ENOG4105CVJ phosphoglycerate mutase G5C61_RS27515 ENOG4105FCD Major Facilitator G5C61_RS27540 ENOG41062IR nudix hydrolase G5C61_RS27560 ENOG41082W1 Cupin 2, conserved barrel domain protein G5C61_RS27620 ENOG4105HHM rdd domain containing protein G5C61_RS27640 ENOG41087PP glycosyltransferase MGT family G5C61_RS27645 ENOG4105YWU small acid-soluble spore protein G5C61_RS27660 ENOG4108RAV Conserved protein G5C61_RS27670 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) G5C61_RS27680 ENOG41080XP Cbs domain G5C61_RS27695 ENOG4107YZX Universal stress protein G5C61_RS27710 ENOG4105C19 ABC transporter G5C61_RS27720 ENOG4105BZU Histidine kinase G5C61_RS27770 ENOG4108URH decarboxylase G5C61_RS27775 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain G5C61_RS27780 ENOG4105DFD Na H antiporter G5C61_RS27825 ENOG4107KM7 Heat induced stress protein YflT G5C61_RS27840 ENOG41069H0 dihydroorotase EC 3.5.2.3 G5C61_RS27850 ENOG4105JSC dimethylmenaquinone methyltransferase G5C61_RS27860 ENOG4105D4T Citrate transporter G5C61_RS27870 ENOG4105E1K spore germination protein G5C61_RS27905 ENOG4105EKQ RNA-directed DNA polymerase G5C61_RS27960 ENOG4108B31 Spore germination protein G5C61_RS27965 ENOG4105E1K spore germination protein G5C61_RS27995 ENOG4105EMU Dehydrogenase G5C61_RS28000 ENOG4105VUF Transcriptional regulator G5C61_RS28025 ENOG4105C0X amino acid G5C61_RS28030 ENOG4105D7N magnesium and cobalt transport protein CorA G5C61_RS28045 ENOG4105CNI cell division protein FtsW G5C61_RS28065 ENOG4107ZYR domain protein G5C61_RS28070 ENOG4105CZN Potassium uptake protein