locus-tag	class	description
HFZ78_RS00010	COG1175	transmembrane transport
HFZ78_RS00015	COG1653	transport
HFZ78_RS00020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS00025	COG2188	Transcriptional regulator
HFZ78_RS00040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HFZ78_RS00080	COG0842	Transport permease protein
HFZ78_RS00090	COG1131	(ABC) transporter
HFZ78_RS00165	COG1175	transmembrane transport
HFZ78_RS00180	COG5578	integral membrane protein
HFZ78_RS00210	COG4638	Rieske (2fe-2S)
HFZ78_RS00225	COG0028	Belongs to the TPP enzyme family
HFZ78_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS00245	COG2223	nitrite transmembrane transporter activity
HFZ78_RS00250	COG1414	Transcriptional regulator
HFZ78_RS00265	COG2323	membrane
HFZ78_RS00295	COG2259	Doxx family
HFZ78_RS00310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFZ78_RS00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_RS00325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFZ78_RS00330	COG0640	Transcriptional regulator
HFZ78_RS00345	COG3347	Dehydrogenase
HFZ78_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS00350	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS00360	COG1653	transport
HFZ78_RS00365	COG0626	cystathionine gamma-synthase activity
HFZ78_RS00380	COG3300	MHYT domain
HFZ78_RS00380	COG5001	Diguanylate cyclase
HFZ78_RS00390	COG4977	sequence-specific DNA binding
HFZ78_RS00390	COG1917	Cupin 2, conserved barrel domain protein
HFZ78_RS00395	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ78_RS00400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ78_RS00405	COG1984	allophanate hydrolase subunit 2
HFZ78_RS00415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS00415	COG1263	PTS System
HFZ78_RS00420	COG1737	Transcriptional regulator
HFZ78_RS00430	COG0561	phosphatase activity
HFZ78_RS00435	COG0277	FAD linked oxidase domain protein
HFZ78_RS00440	COG0247	lactate metabolic process
HFZ78_RS00445	COG4977	sequence-specific DNA binding
HFZ78_RS00450	COG2986	histidine ammonia-lyase
HFZ78_RS00455	COG0477	Major facilitator Superfamily
HFZ78_RS00460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS00470	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_RS00475	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS00480	COG4638	Rieske (2fe-2S)
HFZ78_RS00500	COG0598	Magnesium transport protein CorA
HFZ78_RS00525	COG5002	protein histidine kinase activity
HFZ78_RS00530	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS00550	COG1183	phosphatidylcholine synthase activity
HFZ78_RS00555	COG2217	Heavy metal translocating P-type atpase
HFZ78_RS00570	COG1760	l-serine dehydratase
HFZ78_RS00575	COG1760	l-serine dehydratase
HFZ78_RS00580	COG1113	amino acid transport
HFZ78_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS00595	COG3858	chitin binding
HFZ78_RS00595	COG1388	LysM domain
HFZ78_RS00605	COG1940	carbohydrate kinase activity
HFZ78_RS00615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HFZ78_RS00615	COG2199	diguanylate cyclase activity
HFZ78_RS00645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFZ78_RS00650	COG4172	Belongs to the ABC transporter superfamily
HFZ78_RS00655	COG4721	ABC-type cobalt transport system, permease component
HFZ78_RS00660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFZ78_RS00665	COG3135	benzoate transporter
HFZ78_RS00670	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_RS00675	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS00680	COG1129	ABC transporter
HFZ78_RS00685	COG1869	D-ribose catabolic process
HFZ78_RS00690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS00695	COG1609	Transcriptional regulator
HFZ78_RS00720	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_RS00725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HFZ78_RS00780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS00800	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_RS00805	COG0288	reversible hydration of carbon dioxide
HFZ78_RS00810	COG1846	Transcriptional regulator
HFZ78_RS00815	COG1764	response to oxidative stress
HFZ78_RS00820	COG4086	secreted protein
HFZ78_RS00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_RS00835	COG0805	protein transport
HFZ78_RS00845	COG1414	Transcriptional regulator
HFZ78_RS00850	COG2814	Major facilitator Superfamily
HFZ78_RS00885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_RS00890	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_RS00890	COG1525	nuclease
HFZ78_RS00890	COG4085	toxin activity
HFZ78_RS00925	COG0390	transport system, permease component
HFZ78_RS00930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_RS00940	COG0385	Bile acid
HFZ78_RS01110	COG4499	WXG100 protein secretion system (Wss), protein YukC
HFZ78_RS01110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_RS01115	COG0383	alpha-mannosidase activity
HFZ78_RS01120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS01120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS01125	COG1737	Transcriptional regulator
HFZ78_RS01130	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_RS01135	COG1482	cell wall glycoprotein biosynthetic process
HFZ78_RS01140	COG1842	Phage shock protein A
HFZ78_RS01165	COG2084	Dehydrogenase
HFZ78_RS01175	COG2610	gluconate transmembrane transporter activity
HFZ78_RS01180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_RS01185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_RS01215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFZ78_RS01220	COG1486	melibiose metabolic process
HFZ78_RS01225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_RS01230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_RS01240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_RS01255	COG4821	SIS domain
HFZ78_RS01270	COG2971	BadF BadG BcrA BcrD
HFZ78_RS01345	COG4187	Peptidase family M20/M25/M40
HFZ78_RS01350	COG1802	Transcriptional regulator
HFZ78_RS01355	COG0436	Aminotransferase
HFZ78_RS01360	COG2271	Major facilitator Superfamily
HFZ78_RS01365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFZ78_RS01375	COG1834	amidinotransferase
HFZ78_RS01380	COG0697	spore germination
HFZ78_RS01385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS01440	COG1388	LysM domain
HFZ78_RS01440	COG3584	3D domain protein
HFZ78_RS01445	COG1132	(ABC) transporter
HFZ78_RS01450	COG1132	(ABC) transporter
HFZ78_RS01455	COG1940	carbohydrate kinase activity
HFZ78_RS01460	COG1940	carbohydrate kinase activity
HFZ78_RS01465	COG2723	6-phospho-beta-galactosidase activity
HFZ78_RS01470	COG2207	Transcriptional regulator
HFZ78_RS01470	COG4753	response regulator
HFZ78_RS01475	COG2972	Histidine kinase
HFZ78_RS01485	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS01490	COG4209	transmembrane transport
HFZ78_RS01515	COG0383	alpha-mannosidase activity
HFZ78_RS01535	COG2814	Major facilitator Superfamily
HFZ78_RS01545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFZ78_RS01550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFZ78_RS01570	COG0463	Glycosyl transferase, family 2
HFZ78_RS01570	COG0457	Tetratricopeptide repeat
HFZ78_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS01600	COG1126	abc transporter atp-binding protein
HFZ78_RS01605	COG0833	amino acid
HFZ78_RS01610	COG2986	histidine ammonia-lyase
HFZ78_RS01620	COG0252	asparaginase activity
HFZ78_RS01630	COG3739	integral membrane protein
HFZ78_RS01640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_RS01645	COG1131	(ABC) transporter
HFZ78_RS01650	COG3655	Transcriptional regulator
HFZ78_RS01665	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_RS01665	COG2247	cell wall binding repeat
HFZ78_RS01690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HFZ78_RS01705	COG1134	teichoic acid transport
HFZ78_RS01710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFZ78_RS01845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HFZ78_RS01845	COG0662	Cupin 2, conserved barrel domain protein
HFZ78_RS01855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_RS01870	COG0110	maltose O-acetyltransferase activity
HFZ78_RS01890	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS01920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HFZ78_RS01925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS01930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFZ78_RS01935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFZ78_RS01940	COG4464	protein tyrosine phosphatase activity
HFZ78_RS01945	COG0489	protein tyrosine kinase activity
HFZ78_RS01950	COG3944	biosynthesis protein
HFZ78_RS01965	COG1388	LysM domain
HFZ78_RS01965	COG0791	NLP P60 protein
HFZ78_RS01970	COG3152	Membrane
HFZ78_RS01985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS01990	COG0791	NLP P60 protein
HFZ78_RS01990	COG1388	LysM domain
HFZ78_RS02015	COG2188	Transcriptional regulator
HFZ78_RS02020	COG2723	6-phospho-beta-galactosidase activity
HFZ78_RS02025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_RS02030	COG1609	Transcriptional regulator
HFZ78_RS02035	COG0477	Major facilitator Superfamily
HFZ78_RS02100	COG2076	Multidrug Resistance protein
HFZ78_RS02105	COG2076	Multidrug Resistance protein
HFZ78_RS02110	COG0561	phosphatase activity
HFZ78_RS02145	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_RS02150	COG1131	(ABC) transporter
HFZ78_RS02180	COG1392	Phosphate transport regulator
HFZ78_RS02200	COG3540	Alkaline phosphatase
HFZ78_RS02230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_RS02255	COG2226	methyltransferase
HFZ78_RS02260	COG0656	L-ascorbic acid biosynthetic process
HFZ78_RS02265	COG2814	Major facilitator Superfamily
HFZ78_RS02270	COG1733	regulation of RNA biosynthetic process
HFZ78_RS02280	COG1388	LysM domain
HFZ78_RS02280	COG3584	3D domain protein
HFZ78_RS02290	COG1396	sequence-specific DNA binding
HFZ78_RS02300	COG0629	single-stranded DNA binding
HFZ78_RS02325	COG1077	Cell shape determining protein MreB Mrl
HFZ78_RS02330	COG1609	Transcriptional regulator
HFZ78_RS02340	COG3695	enzyme binding
HFZ78_RS02355	COG0768	penicillin binding
HFZ78_RS02365	COG0739	heme binding
HFZ78_RS02385	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_RS02400	COG4836	Membrane
HFZ78_RS02420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_RS02425	COG0783	Belongs to the Dps family
HFZ78_RS02430	COG2208	phosphoserine phosphatase activity
HFZ78_RS02435	COG1191	sigma factor activity
HFZ78_RS02440	COG2172	sigma factor antagonist activity
HFZ78_RS02445	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_RS02450	COG2208	phosphoserine phosphatase activity
HFZ78_RS02455	COG2172	sigma factor antagonist activity
HFZ78_RS02460	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_RS02465	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_RS02480	COG0598	Magnesium transport protein CorA
HFZ78_RS02495	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_RS02500	COG1253	flavin adenine dinucleotide binding
HFZ78_RS02505	COG0668	transmembrane transport
HFZ78_RS02520	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HFZ78_RS02525	COG1007	ATP synthesis coupled electron transport
HFZ78_RS02535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFZ78_RS02540	COG0713	ATP synthesis coupled electron transport
HFZ78_RS02545	COG0839	Belongs to the complex I subunit 6 family
HFZ78_RS02555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFZ78_RS02560	COG0649	NAD binding
HFZ78_RS02565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_RS02570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_RS02575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_RS02590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFZ78_RS02595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFZ78_RS02600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFZ78_RS02605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ78_RS02610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFZ78_RS02615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ78_RS02620	COG0356	it plays a direct role in the translocation of protons across the membrane
HFZ78_RS02635	COG1404	Belongs to the peptidase S8 family
HFZ78_RS02645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFZ78_RS02660	COG0698	ribose 5-phosphate isomerase
HFZ78_RS02670	COG1971	Probably functions as a manganese efflux pump
HFZ78_RS02675	COG0009	L-threonylcarbamoyladenylate synthase
HFZ78_RS02695	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ78_RS02700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFZ78_RS02710	COG1435	thymidine kinase activity
HFZ78_RS02720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HFZ78_RS02725	COG1494	fructose-1,6-bisphosphatase
HFZ78_RS02740	COG0191	fructose-bisphosphate aldolase activity
HFZ78_RS02745	COG2204	response regulator
HFZ78_RS02750	COG4821	SIS domain
HFZ78_RS02755	COG0504	CTP synthase activity
HFZ78_RS02760	COG3343	RNA polymerase activity
HFZ78_RS02770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS02770	COG1703	isobutyryl-CoA mutase activity
HFZ78_RS02770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS02780	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS02785	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS02790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_RS02795	COG0183	Belongs to the thiolase family
HFZ78_RS02800	COG0247	lactate metabolic process
HFZ78_RS02800	COG2181	nitrate reductase activity
HFZ78_RS02805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_RS02830	COG0010	Belongs to the arginase family
HFZ78_RS02835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HFZ78_RS02840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_RS02850	COG1994	Peptidase M50
HFZ78_RS02860	COG3465	dGTPase activity
HFZ78_RS02865	COG1078	dGTPase activity
HFZ78_RS02870	COG4844	belongs to the
HFZ78_RS02885	COG0280	phosphate acetyltransferase
HFZ78_RS02900	COG2363	Small membrane protein
HFZ78_RS02910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_RS02915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HFZ78_RS02920	COG0314	molybdopterin synthase activity
HFZ78_RS02925	COG1910	domain protein
HFZ78_RS02930	COG0303	'Molybdopterin
HFZ78_RS02935	COG0746	molybdenum cofactor guanylyltransferase activity
HFZ78_RS02945	COG0351	phosphomethylpyrimidine kinase
HFZ78_RS02950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_RS02960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS02970	COG4263	nitrous-oxide reductase activity
HFZ78_RS02990	COG1131	(ABC) transporter
HFZ78_RS03000	COG2133	pyrroloquinoline quinone binding
HFZ78_RS03005	COG0561	phosphatase activity
HFZ78_RS03035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFZ78_RS03050	COG0411	ABC transporter
HFZ78_RS03070	COG0477	Major facilitator Superfamily
HFZ78_RS03075	COG1132	(ABC) transporter
HFZ78_RS03080	COG1132	(ABC) transporter
HFZ78_RS03115	COG1131	(ABC) transporter
HFZ78_RS03130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFZ78_RS03165	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_RS03170	COG1187	pseudouridine synthase activity
HFZ78_RS03185	COG4989	oxidoreductase activity
HFZ78_RS03190	COG3584	3D domain protein
HFZ78_RS03190	COG1388	LysM domain
HFZ78_RS03200	COG1473	amidohydrolase
HFZ78_RS03205	COG2190	(PTS) system
HFZ78_RS03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS03205	COG1263	PTS System
HFZ78_RS03210	COG2222	sugar isomerase
HFZ78_RS03215	COG2188	Transcriptional regulator
HFZ78_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS03230	COG1126	abc transporter atp-binding protein
HFZ78_RS03235	COG0765	amino acid transport
HFZ78_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS03245	COG0246	Mannitol dehydrogenase
HFZ78_RS03255	COG2721	sulfolactate sulfo-lyase activity
HFZ78_RS03260	COG1063	alcohol dehydrogenase
HFZ78_RS03265	COG2271	Major facilitator Superfamily
HFZ78_RS03270	COG1802	Transcriptional regulator
HFZ78_RS03285	COG0246	Mannitol dehydrogenase
HFZ78_RS03290	COG1312	Catalyzes the dehydration of D-mannonate
HFZ78_RS03295	COG1063	alcohol dehydrogenase
HFZ78_RS03300	COG2271	Major facilitator Superfamily
HFZ78_RS03305	COG2040	homocysteine
HFZ78_RS03310	COG0833	amino acid
HFZ78_RS03315	COG1404	Belongs to the peptidase S8 family
HFZ78_RS03330	COG0183	Belongs to the thiolase family
HFZ78_RS03335	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS03340	COG1268	BioY protein
HFZ78_RS03365	COG0778	Nitroreductase
HFZ78_RS03385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_RS03390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFZ78_RS03395	COG4853	Protein conserved in bacteria
HFZ78_RS03400	COG4863	YycH protein
HFZ78_RS03405	COG5002	protein histidine kinase activity
HFZ78_RS03410	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS03450	COG0305	Participates in initiation and elongation during chromosome replication
HFZ78_RS03460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HFZ78_RS03470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFZ78_RS03475	COG0629	single-stranded DNA binding
HFZ78_RS03480	COG0360	Binds together with S18 to 16S ribosomal RNA
HFZ78_RS03485	COG0012	GTP binding
HFZ78_RS03495	COG0243	molybdopterin cofactor binding
HFZ78_RS03500	COG4481	Protein conserved in bacteria
HFZ78_RS03505	COG0668	transmembrane transport
HFZ78_RS03520	COG1475	DNA binding
HFZ78_RS03525	COG1192	Involved in chromosome partitioning
HFZ78_RS03530	COG1475	DNA binding
HFZ78_RS03540	COG0445	tRNA wobble uridine modification
HFZ78_RS03545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HFZ78_RS03550	COG1847	R3H domain protein
HFZ78_RS03560	COG0594	ribonuclease P activity
HFZ78_RS03575	COG0592	DNA-directed DNA polymerase activity
HFZ78_RS03580	COG2501	S4 domain
HFZ78_RS03585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ78_RS03595	COG0187	DNA topoisomerase II activity
HFZ78_RS03600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ78_RS03635	COG0517	IMP dehydrogenase activity
HFZ78_RS03635	COG0516	GMP reductase activity
HFZ78_RS03650	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HFZ78_RS03665	COG1428	Deoxynucleoside kinase
HFZ78_RS03670	COG1428	Deoxynucleoside kinase
HFZ78_RS03675	COG1388	LysM domain
HFZ78_RS03675	COG3858	chitin binding
HFZ78_RS03680	COG1335	isochorismatase
HFZ78_RS03685	COG0590	tRNA wobble adenosine to inosine editing
HFZ78_RS03695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFZ78_RS03700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFZ78_RS03705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFZ78_RS03750	COG1982	Orn Lys Arg decarboxylase major
HFZ78_RS03755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HFZ78_RS03760	COG3870	Protein conserved in bacteria
HFZ78_RS03765	COG0470	DNA polymerase III
HFZ78_RS03770	COG1774	PSP1 C-terminal conserved region
HFZ78_RS03775	COG4467	Involved in initiation control of chromosome replication
HFZ78_RS03780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HFZ78_RS03790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFZ78_RS03795	COG2002	toxin-antitoxin pair type II binding
HFZ78_RS03805	COG0084	hydrolase, TatD family'
HFZ78_RS03810	COG3583	domain protein
HFZ78_RS03810	COG3584	3D domain protein
HFZ78_RS03820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFZ78_RS03830	COG4466	Protein conserved in bacteria
HFZ78_RS03845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_RS03850	COG0251	oxidation-reduction process
HFZ78_RS03855	COG2088	sporulation resulting in formation of a cellular spore
HFZ78_RS03860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFZ78_RS03870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HFZ78_RS03875	COG0193	aminoacyl-tRNA hydrolase activity
HFZ78_RS03885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFZ78_RS03890	COG2002	toxin-antitoxin pair type II binding
HFZ78_RS03895	COG2244	polysaccharide biosynthetic process
HFZ78_RS03900	COG3956	TIGRFAM MazG family protein
HFZ78_RS03905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFZ78_RS03925	COG1098	S1 RNA binding domain
HFZ78_RS03930	COG2208	phosphoserine phosphatase activity
HFZ78_RS03935	COG2304	oxidoreductase activity
HFZ78_RS03940	COG0515	serine threonine protein kinase
HFZ78_RS03955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_RS03960	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HFZ78_RS03965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFZ78_RS03970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_RS03975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_RS03980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFZ78_RS03985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFZ78_RS03990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFZ78_RS03995	COG1396	sequence-specific DNA binding
HFZ78_RS04000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ78_RS04090	COG3880	PFAM UvrB UvrC protein
HFZ78_RS04095	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HFZ78_RS04100	COG0542	response to heat
HFZ78_RS04105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HFZ78_RS04115	COG4956	integral membrane protein (PIN domain superfamily)
HFZ78_RS04120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HFZ78_RS04125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HFZ78_RS04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFZ78_RS04135	COG1045	serine acetyltransferase
HFZ78_RS04140	COG0215	cysteine-tRNA ligase activity
HFZ78_RS04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFZ78_RS04155	COG3688	RNA-binding protein containing a PIN domain
HFZ78_RS04165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_RS04170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFZ78_RS04175	COG0250	Participates in transcription elongation, termination and antitermination
HFZ78_RS04180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HFZ78_RS04185	COG0081	regulation of translation
HFZ78_RS04190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HFZ78_RS04195	COG0222	ribosome binding
HFZ78_RS04200	COG2813	Specifically methylates the guanine in position
HFZ78_RS04215	COG1358	cellular component organization or biogenesis
HFZ78_RS04220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFZ78_RS04225	COG0049	tRNA binding
HFZ78_RS04230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HFZ78_RS04235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFZ78_RS04245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HFZ78_RS04250	COG0088	Forms part of the polypeptide exit tunnel
HFZ78_RS04260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFZ78_RS04275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFZ78_RS04280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HFZ78_RS04295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFZ78_RS04300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFZ78_RS04320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFZ78_RS04330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFZ78_RS04335	COG1841	ribosomal large subunit assembly
HFZ78_RS04345	COG0201	protein transport
HFZ78_RS04350	COG0563	adenylate kinase activity
HFZ78_RS04355	COG0024	Methionine aminopeptidase
HFZ78_RS04360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFZ78_RS04365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFZ78_RS04370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFZ78_RS04375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HFZ78_RS04380	COG0202	RNA polymerase activity
HFZ78_RS04385	COG0203	ribosomal protein L17
HFZ78_RS04390	COG1122	ATPase activity
HFZ78_RS04395	COG1122	ATPase activity
HFZ78_RS04400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFZ78_RS04405	COG0101	tRNA pseudouridine synthase activity
HFZ78_RS04410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HFZ78_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFZ78_RS04430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFZ78_RS04440	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HFZ78_RS04445	COG0535	radical SAM domain protein
HFZ78_RS04455	COG0517	IMP dehydrogenase activity
HFZ78_RS04465	COG1027	Aspartate ammonia-lyase
HFZ78_RS04470	COG4191	Histidine kinase
HFZ78_RS04475	COG0784	Response regulator, receiver
HFZ78_RS04485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFZ78_RS04505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS04515	COG2197	response regulator
HFZ78_RS04520	COG2203	Gaf domain
HFZ78_RS04520	COG4585	Histidine kinase
HFZ78_RS04525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFZ78_RS04530	COG0300	oxidoreductase activity
HFZ78_RS04545	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_RS04550	COG0489	protein tyrosine kinase activity
HFZ78_RS04560	COG2194	sulfuric ester hydrolase activity
HFZ78_RS04565	COG0726	polysaccharide deacetylase
HFZ78_RS04635	COG1595	DNA-templated transcription, initiation
HFZ78_RS04640	COG5662	AntiSigma factor
HFZ78_RS04645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HFZ78_RS04650	COG4856	YbbR-like protein
HFZ78_RS04655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFZ78_RS04660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFZ78_RS04670	COG3711	transcriptional antiterminator
HFZ78_RS04675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS04685	COG5002	protein histidine kinase activity
HFZ78_RS04690	COG1846	Transcriptional regulator
HFZ78_RS04695	COG2259	Doxx family
HFZ78_RS04700	COG0346	lactoylglutathione lyase activity
HFZ78_RS04705	COG0346	lactoylglutathione lyase activity
HFZ78_RS04710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HFZ78_RS04725	COG4555	ABC transporter
HFZ78_RS04740	COG1309	transcriptional regulator
HFZ78_RS04755	COG0018	arginyl-trna synthetase
HFZ78_RS04765	COG0531	amino acid
HFZ78_RS04775	COG0586	Pfam SNARE associated Golgi protein
HFZ78_RS04780	COG2239	Acts as a magnesium transporter
HFZ78_RS04795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFZ78_RS04800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFZ78_RS04810	COG4294	response to UV
HFZ78_RS04815	COG3402	PFAM membrane-flanked domain
HFZ78_RS04820	COG3428	Bacterial PH domain
HFZ78_RS04825	COG0705	Rhomboid family
HFZ78_RS04830	COG0736	holo-[acyl-carrier-protein] synthase activity
HFZ78_RS04835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFZ78_RS04845	COG0864	Transcriptional regulator
HFZ78_RS04850	COG2337	Toxic component of a toxin-antitoxin (TA) module
HFZ78_RS04855	COG2183	response to ionizing radiation
HFZ78_RS04865	COG3091	SprT-like family
HFZ78_RS04940	COG0802	atpase or kinase
HFZ78_RS04945	COG1214	PFAM Peptidase M22, glycoprotease
HFZ78_RS04950	COG0456	acetyltransferase
HFZ78_RS04960	COG0488	(ABC) transporter
HFZ78_RS04965	COG0315	cyclic pyranopterin monophosphate synthase activity
HFZ78_RS04970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HFZ78_RS04975	COG0281	malic enzyme
HFZ78_RS04980	COG0730	response to heat
HFZ78_RS04985	COG3290	protein histidine kinase activity
HFZ78_RS04990	COG4565	transcriptional regulatory protein
HFZ78_RS04995	COG3493	citrate carrier protein
HFZ78_RS05000	COG0281	malic enzyme
HFZ78_RS05005	COG0789	Transcriptional regulator
HFZ78_RS05010	COG1664	Polymer-forming cytoskeletal
HFZ78_RS05015	COG1664	Polymer-forming cytoskeletal
HFZ78_RS05020	COG2814	Major facilitator Superfamily
HFZ78_RS05030	COG1266	CAAX protease self-immunity
HFZ78_RS05040	COG0459	protein refolding
HFZ78_RS05045	COG1486	melibiose metabolic process
HFZ78_RS05060	COG1175	transmembrane transport
HFZ78_RS05065	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS05085	COG3459	Glycosyltransferase 36 associated
HFZ78_RS05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_RS05095	COG1607	acyl-coa hydrolase
HFZ78_RS05105	COG4191	Histidine kinase
HFZ78_RS05115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS05120	COG1115	amino acid carrier protein
HFZ78_RS05125	COG0517	IMP dehydrogenase activity
HFZ78_RS05135	COG1819	glycosyl
HFZ78_RS05150	COG0457	Tetratricopeptide repeat
HFZ78_RS05155	COG1063	alcohol dehydrogenase
HFZ78_RS05160	COG2211	Major facilitator Superfamily
HFZ78_RS05165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS05255	COG0714	Associated with various cellular activities
HFZ78_RS05260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HFZ78_RS05265	COG1305	Transglutaminase-like
HFZ78_RS05270	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ78_RS05270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFZ78_RS05275	COG2252	PERMEase
HFZ78_RS05280	COG3711	transcriptional antiterminator
HFZ78_RS05285	COG1263	PTS System
HFZ78_RS05285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS05285	COG2190	(PTS) system
HFZ78_RS05305	COG0668	transmembrane transport
HFZ78_RS05315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFZ78_RS05320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFZ78_RS05325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFZ78_RS05330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFZ78_RS05335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_RS05340	COG0047	phosphoribosylformylglycinamidine synthase activity
HFZ78_RS05350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFZ78_RS05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFZ78_RS05370	COG0151	Belongs to the GarS family
HFZ78_RS05385	COG1470	cell adhesion involved in biofilm formation
HFZ78_RS05390	COG4496	protein, YerC YecD
HFZ78_RS05395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HFZ78_RS05400	COG0210	DNA helicase
HFZ78_RS05405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFZ78_RS05410	COG4851	CamS sex pheromone cAM373 precursor
HFZ78_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS05440	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_RS05445	COG1587	Uroporphyrinogen-III synthase
HFZ78_RS05445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFZ78_RS05455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFZ78_RS05460	COG2224	Isocitrate lyase
HFZ78_RS05465	COG5506	Protein of unknown function (DUF1694)
HFZ78_RS05470	COG1764	response to oxidative stress
HFZ78_RS05480	COG0741	lytic transglycosylase activity
HFZ78_RS05485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ78_RS05490	COG0154	amidase activity
HFZ78_RS05495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ78_RS05500	COG0346	lactoylglutathione lyase activity
HFZ78_RS05510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS05525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFZ78_RS05555	COG1597	lipid kinase activity
HFZ78_RS05560	COG1335	isochorismatase
HFZ78_RS05565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFZ78_RS05590	COG0791	NLP P60 protein
HFZ78_RS05590	COG1388	LysM domain
HFZ78_RS05615	COG5002	protein histidine kinase activity
HFZ78_RS05620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HFZ78_RS05630	COG2197	response regulator
HFZ78_RS05650	COG1268	BioY protein
HFZ78_RS05655	COG2972	Histidine kinase
HFZ78_RS05660	COG4753	response regulator
HFZ78_RS05660	COG2207	Transcriptional regulator
HFZ78_RS05665	COG1653	transport
HFZ78_RS05675	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS05680	COG5578	integral membrane protein
HFZ78_RS05685	COG3507	Belongs to the glycosyl hydrolase 43 family
HFZ78_RS05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS05700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS05705	COG1120	ATPase activity
HFZ78_RS05725	COG2235	arginine
HFZ78_RS05735	COG0833	amino acid
HFZ78_RS05740	COG4187	Peptidase family M20/M25/M40
HFZ78_RS05745	COG1785	Belongs to the alkaline phosphatase family
HFZ78_RS05760	COG2207	Transcriptional regulator
HFZ78_RS05760	COG4753	response regulator
HFZ78_RS05765	COG2972	Histidine kinase
HFZ78_RS05785	COG3250	beta-galactosidase activity
HFZ78_RS05795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HFZ78_RS05800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ78_RS05805	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HFZ78_RS05810	COG2017	converts alpha-aldose to the beta-anomer
HFZ78_RS05815	COG1609	Transcriptional regulator
HFZ78_RS05825	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS05830	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS05840	COG2972	Histidine kinase
HFZ78_RS05845	COG2201	protein-glutamate methylesterase activity
HFZ78_RS05855	COG1129	ABC transporter
HFZ78_RS05860	COG4211	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS05875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS05880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS05885	COG2610	gluconate transmembrane transporter activity
HFZ78_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS05895	COG3290	protein histidine kinase activity
HFZ78_RS05895	COG3829	transcription factor binding
HFZ78_RS05900	COG1132	(ABC) transporter
HFZ78_RS05910	COG5002	protein histidine kinase activity
HFZ78_RS05925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_RS05930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFZ78_RS05935	COG1823	symporter activity
HFZ78_RS05940	COG2514	catechol 2,3-dioxygenase activity
HFZ78_RS05965	COG2972	Histidine kinase
HFZ78_RS05975	COG2207	Transcriptional regulator
HFZ78_RS05975	COG4753	response regulator
HFZ78_RS05985	COG1175	transmembrane transport
HFZ78_RS05990	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS06005	COG3250	beta-galactosidase activity
HFZ78_RS06010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_RS06025	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_RS06030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_RS06060	COG5002	protein histidine kinase activity
HFZ78_RS06065	COG0561	phosphatase activity
HFZ78_RS06070	COG1609	Transcriptional regulator
HFZ78_RS06150	COG1609	Transcriptional regulator
HFZ78_RS06155	COG0366	Alpha amylase catalytic
HFZ78_RS06160	COG1653	transport
HFZ78_RS06165	COG1175	transmembrane transport
HFZ78_RS06170	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS06175	COG1063	alcohol dehydrogenase
HFZ78_RS06180	COG1082	Xylose isomerase domain protein TIM barrel
HFZ78_RS06185	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS06190	COG1554	hydrolase, family 65, central catalytic
HFZ78_RS06195	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_RS06200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFZ78_RS06220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFZ78_RS06230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS06270	COG1216	Glycosyl transferase, family 2
HFZ78_RS06295	COG2046	Belongs to the sulfate adenylyltransferase family
HFZ78_RS06300	COG0730	response to heat
HFZ78_RS06310	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS06325	COG1086	Polysaccharide biosynthesis protein
HFZ78_RS06340	COG3239	Fatty acid desaturase
HFZ78_RS06345	COG2197	response regulator
HFZ78_RS06350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_RS06400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS06415	COG1609	Transcriptional regulator
HFZ78_RS06420	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFZ78_RS06425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFZ78_RS06430	COG2824	Alkylphosphonate utilization operon protein PhnA
HFZ78_RS06440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFZ78_RS06450	COG2323	membrane
HFZ78_RS06455	COG0025	NhaP-type Na H and K H
HFZ78_RS06460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_RS06480	COG0347	Belongs to the P(II) protein family
HFZ78_RS06485	COG0004	ammonium transporteR
HFZ78_RS06490	COG1988	membrane-bound metal-dependent
HFZ78_RS06495	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS06500	COG1785	Belongs to the alkaline phosphatase family
HFZ78_RS06520	COG2508	Transcriptional regulator
HFZ78_RS06530	COG1228	amidohydrolase
HFZ78_RS06540	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_RS06545	COG1953	Uracil, thiamine, allantoin
HFZ78_RS06555	COG2207	Transcriptional regulator
HFZ78_RS06555	COG4753	response regulator
HFZ78_RS06560	COG2972	Histidine kinase
HFZ78_RS06565	COG4608	Belongs to the ABC transporter superfamily
HFZ78_RS06570	COG0444	Belongs to the ABC transporter superfamily
HFZ78_RS06590	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_RS06595	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_RS06600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFZ78_RS06605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_RS06610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFZ78_RS06630	COG2267	carboxylic ester hydrolase activity
HFZ78_RS06635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HFZ78_RS06650	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS06665	COG3123	guanosine phosphorylase activity
HFZ78_RS06690	COG1473	amidohydrolase
HFZ78_RS06695	COG1473	amidohydrolase
HFZ78_RS06715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_RS06740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFZ78_RS06745	COG1309	transcriptional regulator
HFZ78_RS06765	COG0604	alcohol dehydrogenase
HFZ78_RS06790	COG2271	Major facilitator Superfamily
HFZ78_RS06800	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS06805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFZ78_RS06810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_RS06815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFZ78_RS06815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HFZ78_RS06820	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_RS06830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_RS06835	COG2723	6-phospho-beta-galactosidase activity
HFZ78_RS06840	COG4191	Histidine kinase
HFZ78_RS06870	COG1414	Transcriptional regulator
HFZ78_RS06880	COG2721	sulfolactate sulfo-lyase activity
HFZ78_RS06885	COG2721	sulfolactate sulfo-lyase activity
HFZ78_RS06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_RS06900	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS06915	COG0861	Integral membrane protein TerC family
HFZ78_RS06930	COG1335	isochorismatase
HFZ78_RS06960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFZ78_RS06975	COG0531	amino acid
HFZ78_RS06980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HFZ78_RS06985	COG1309	transcriptional regulator
HFZ78_RS06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS07005	COG2368	4-hydroxyphenylacetate
HFZ78_RS07025	COG0196	riboflavin kinase activity
HFZ78_RS07030	COG0477	Major facilitator Superfamily
HFZ78_RS07040	COG0531	amino acid
HFZ78_RS07060	COG0531	amino acid
HFZ78_RS07065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS07075	COG3829	transcription factor binding
HFZ78_RS07075	COG3290	protein histidine kinase activity
HFZ78_RS07080	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS07090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFZ78_RS07095	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS07100	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_RS07105	COG1129	ABC transporter
HFZ78_RS07110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS07115	COG1070	Carbohydrate kinase
HFZ78_RS07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS07125	COG2188	Transcriptional regulator
HFZ78_RS07140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_RS07145	COG0697	spore germination
HFZ78_RS07150	COG3118	belongs to the thioredoxin family
HFZ78_RS07155	COG0583	DNA-binding transcription factor activity
HFZ78_RS07170	COG3964	amidohydrolase
HFZ78_RS07190	COG2188	Transcriptional regulator
HFZ78_RS07200	COG0693	protein deglycase activity
HFZ78_RS07230	COG0579	oxidoreductase
HFZ78_RS07250	COG0534	Mate efflux family protein
HFZ78_RS07255	COG3773	Cell wall hydrolase
HFZ78_RS07270	COG1764	response to oxidative stress
HFZ78_RS07280	COG2323	membrane
HFZ78_RS07315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFZ78_RS07325	COG1349	DNA-binding transcription factor activity
HFZ78_RS07355	COG1595	DNA-templated transcription, initiation
HFZ78_RS07370	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS07380	COG0196	riboflavin kinase activity
HFZ78_RS07385	COG3384	dioxygenase
HFZ78_RS07405	COG2807	transmembrane transport
HFZ78_RS07435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS07455	COG4191	Histidine kinase
HFZ78_RS07460	COG0784	Response regulator, receiver
HFZ78_RS07465	COG0281	malic enzyme
HFZ78_RS07475	COG5002	protein histidine kinase activity
HFZ78_RS07505	COG2132	Multicopper oxidase
HFZ78_RS07525	COG2720	vancomycin resistance protein
HFZ78_RS07535	COG0697	spore germination
HFZ78_RS07555	COG1070	Carbohydrate kinase
HFZ78_RS07560	COG2814	Major facilitator Superfamily
HFZ78_RS07560	COG0477	Major facilitator Superfamily
HFZ78_RS07570	COG1940	carbohydrate kinase activity
HFZ78_RS07575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_RS07580	COG2340	Cysteine-rich secretory protein family
HFZ78_RS07620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HFZ78_RS07625	COG0656	L-ascorbic acid biosynthetic process
HFZ78_RS07630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_RS07660	COG2814	Major facilitator Superfamily
HFZ78_RS07670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_RS07675	COG2267	carboxylic ester hydrolase activity
HFZ78_RS07700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFZ78_RS07710	COG4208	sulfate ABC transporter
HFZ78_RS07730	COG1070	Carbohydrate kinase
HFZ78_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS07760	COG3347	Dehydrogenase
HFZ78_RS07765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFZ78_RS07775	COG1070	Carbohydrate kinase
HFZ78_RS07785	COG2258	MOSC domain
HFZ78_RS07805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS07810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFZ78_RS07830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ78_RS07860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HFZ78_RS07885	COG0640	Transcriptional regulator
HFZ78_RS07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS07895	COG1309	transcriptional regulator
HFZ78_RS07925	COG0346	lactoylglutathione lyase activity
HFZ78_RS07930	COG2076	Multidrug Resistance protein
HFZ78_RS07935	COG2076	Multidrug Resistance protein
HFZ78_RS07960	COG2972	Histidine kinase
HFZ78_RS07965	COG2207	Transcriptional regulator
HFZ78_RS07965	COG4753	response regulator
HFZ78_RS07975	COG4753	response regulator
HFZ78_RS07975	COG2207	Transcriptional regulator
HFZ78_RS07995	COG4209	transmembrane transport
HFZ78_RS08000	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS08010	COG1621	beta-fructofuranosidase activity
HFZ78_RS08015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS08020	COG0561	phosphatase activity
HFZ78_RS08025	COG1609	Transcriptional regulator
HFZ78_RS08030	COG4209	transmembrane transport
HFZ78_RS08035	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS08040	COG1653	transport
HFZ78_RS08045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS08055	COG1621	beta-fructofuranosidase activity
HFZ78_RS08065	COG1621	beta-fructofuranosidase activity
HFZ78_RS08070	COG1621	beta-fructofuranosidase activity
HFZ78_RS08085	COG1621	beta-fructofuranosidase activity
HFZ78_RS08090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS08090	COG1263	PTS System
HFZ78_RS08095	COG3711	transcriptional antiterminator
HFZ78_RS08105	COG1609	Transcriptional regulator
HFZ78_RS08110	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS08115	COG2207	Transcriptional regulator
HFZ78_RS08125	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS08140	COG0366	Alpha amylase catalytic
HFZ78_RS08145	COG1609	Transcriptional regulator
HFZ78_RS08150	COG1653	transport
HFZ78_RS08155	COG1175	transmembrane transport
HFZ78_RS08160	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS08180	COG0385	Bile acid
HFZ78_RS08200	COG0590	tRNA wobble adenosine to inosine editing
HFZ78_RS08205	COG2068	MobA-Related Protein
HFZ78_RS08215	COG3195	allantoin biosynthetic process
HFZ78_RS08215	COG3648	Uricase
HFZ78_RS08220	COG2351	hydroxyisourate hydrolase activity
HFZ78_RS08225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFZ78_RS08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_RS08235	COG0831	urea catabolic process
HFZ78_RS08240	COG0832	Belongs to the urease beta subunit family
HFZ78_RS08250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HFZ78_RS08255	COG0830	nickel cation binding
HFZ78_RS08265	COG0829	nickel cation binding
HFZ78_RS08285	COG0166	Belongs to the GPI family
HFZ78_RS08290	COG3189	MarR family transcriptional regulator
HFZ78_RS08305	COG5434	Belongs to the glycosyl hydrolase 28 family
HFZ78_RS08320	COG0456	acetyltransferase
HFZ78_RS08325	COG0066	3-isopropylmalate dehydratase activity
HFZ78_RS08330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HFZ78_RS08335	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_RS08340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_RS08345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HFZ78_RS08350	COG0440	acetolactate synthase activity
HFZ78_RS08355	COG0028	Belongs to the TPP enzyme family
HFZ78_RS08360	COG0129	dihydroxy-acid dehydratase activity
HFZ78_RS08365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_RS08370	COG2176	DNA-directed DNA polymerase activity
HFZ78_RS08380	COG0004	ammonium transporteR
HFZ78_RS08385	COG0789	Transcriptional regulator
HFZ78_RS08410	COG0765	amino acid transport
HFZ78_RS08430	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS08440	COG1690	Belongs to the RtcB family
HFZ78_RS08450	COG2814	Major facilitator Superfamily
HFZ78_RS08460	COG3829	transcription factor binding
HFZ78_RS08460	COG3290	protein histidine kinase activity
HFZ78_RS08475	COG0183	Belongs to the thiolase family
HFZ78_RS08485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ78_RS08495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFZ78_RS08500	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_RS08505	COG2116	formate transmembrane transporter activity
HFZ78_RS08510	COG0535	radical SAM domain protein
HFZ78_RS08520	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS08525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_RS08530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_RS08535	COG2271	Major facilitator Superfamily
HFZ78_RS08545	COG1129	ABC transporter
HFZ78_RS08550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS08560	COG2222	sugar isomerase
HFZ78_RS08565	COG1653	transport
HFZ78_RS08570	COG1175	transmembrane transport
HFZ78_RS08575	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS08580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS08585	COG2188	Transcriptional regulator
HFZ78_RS08590	COG2966	Psort location CytoplasmicMembrane, score
HFZ78_RS08595	COG3610	response to peptide
HFZ78_RS08600	COG4990	cell redox homeostasis
HFZ78_RS08605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFZ78_RS08635	COG3275	phosphorelay sensor kinase activity
HFZ78_RS08640	COG3279	Response regulator of the LytR AlgR family
HFZ78_RS08645	COG1966	Carbon starvation protein
HFZ78_RS08650	COG0531	amino acid
HFZ78_RS08655	COG5002	protein histidine kinase activity
HFZ78_RS08660	COG3437	response regulator, receiver
HFZ78_RS08675	COG0243	molybdopterin cofactor binding
HFZ78_RS08710	COG2197	response regulator
HFZ78_RS08730	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS08735	COG0348	domain, Protein
HFZ78_RS08760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS08770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS08780	COG0513	Belongs to the DEAD box helicase family
HFZ78_RS08785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_RS08785	COG0723	plastoquinol--plastocyanin reductase activity
HFZ78_RS08800	COG2340	Cysteine-rich secretory protein family
HFZ78_RS08810	COG1842	Phage shock protein A
HFZ78_RS08825	COG2197	response regulator
HFZ78_RS08840	COG2244	polysaccharide biosynthetic process
HFZ78_RS08850	COG3186	Phenylalanine-4-hydroxylase
HFZ78_RS08855	COG0670	Belongs to the BI1 family
HFZ78_RS08865	COG2309	aminopeptidase activity
HFZ78_RS08875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_RS08875	COG0551	DNA topoisomerase type I activity
HFZ78_RS08880	COG2986	histidine ammonia-lyase
HFZ78_RS08895	COG1396	sequence-specific DNA binding
HFZ78_RS08900	COG0024	Methionine aminopeptidase
HFZ78_RS08905	COG4840	Belongs to the UPF0435 family
HFZ78_RS08915	COG1295	ribonuclease BN
HFZ78_RS08920	COG2217	Heavy metal translocating P-type atpase
HFZ78_RS08925	COG0477	Major facilitator Superfamily
HFZ78_RS08930	COG0387	Pfam Sodium calcium exchanger
HFZ78_RS08935	COG2364	Membrane
HFZ78_RS08965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFZ78_RS08970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_RS08975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_RS08990	COG0531	amino acid
HFZ78_RS09005	COG0569	domain protein
HFZ78_RS09010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_RS09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ78_RS09050	COG0667	Aldo Keto reductase
HFZ78_RS09055	COG0778	Nitroreductase
HFZ78_RS09075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ78_RS09110	COG0697	spore germination
HFZ78_RS09140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFZ78_RS09165	COG0640	Transcriptional regulator
HFZ78_RS09190	COG4807	Protein conserved in bacteria
HFZ78_RS09195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFZ78_RS09205	COG1414	Transcriptional regulator
HFZ78_RS09215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_RS09220	COG2610	gluconate transmembrane transporter activity
HFZ78_RS09230	COG1846	Transcriptional regulator
HFZ78_RS09235	COG0386	Belongs to the glutathione peroxidase family
HFZ78_RS09255	COG0322	excinuclease ABC activity
HFZ78_RS09260	COG3104	oligopeptide transport
HFZ78_RS09265	COG0789	Transcriptional regulator
HFZ78_RS09270	COG0444	Belongs to the ABC transporter superfamily
HFZ78_RS09275	COG4608	Belongs to the ABC transporter superfamily
HFZ78_RS09280	COG0747	negative chemotaxis
HFZ78_RS09295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFZ78_RS09300	COG0710	3-dehydroquinate dehydratase activity
HFZ78_RS09310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HFZ78_RS09315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFZ78_RS09320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFZ78_RS09325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_RS09330	COG0505	Belongs to the CarA family
HFZ78_RS09335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_RS09340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HFZ78_RS09345	COG0137	argininosuccinate synthase activity
HFZ78_RS09350	COG0165	Argininosuccinate lyase
HFZ78_RS09355	COG3153	acetyltransferase
HFZ78_RS09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ78_RS09360	COG0456	acetyltransferase
HFZ78_RS09370	COG0460	homoserine dehydrogenase
HFZ78_RS09385	COG1090	epimerase
HFZ78_RS09390	COG2137	regulation of response to DNA damage stimulus
HFZ78_RS09415	COG1988	membrane-bound metal-dependent
HFZ78_RS09420	COG1194	a g-specific adenine glycosylase
HFZ78_RS09430	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS09450	COG1132	(ABC) transporter
HFZ78_RS09455	COG4129	membrane
HFZ78_RS09460	COG0067	glutamate synthase
HFZ78_RS09460	COG0069	glutamate synthase activity
HFZ78_RS09460	COG0070	glutamate synthase
HFZ78_RS09465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFZ78_RS09470	COG4555	ABC transporter
HFZ78_RS09490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFZ78_RS09495	COG0735	belongs to the Fur family
HFZ78_RS09610	COG3382	B3 4 domain protein
HFZ78_RS09615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFZ78_RS09625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFZ78_RS09630	COG0778	Nitroreductase
HFZ78_RS09635	COG2766	serine protein kinase
HFZ78_RS09645	COG3142	Participates in the control of copper homeostasis
HFZ78_RS09655	COG0784	Response regulator, receiver
HFZ78_RS09660	COG4191	Histidine kinase
HFZ78_RS09670	COG2190	(PTS) system
HFZ78_RS09670	COG1263	PTS System
HFZ78_RS09670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS09675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFZ78_RS09680	COG0363	glucosamine-6-phosphate deaminase activity
HFZ78_RS09685	COG2188	Transcriptional regulator
HFZ78_RS09690	COG4821	SIS domain
HFZ78_RS09695	COG2340	Cysteine-rich secretory protein family
HFZ78_RS09700	COG5002	protein histidine kinase activity
HFZ78_RS09705	COG5001	Diguanylate cyclase
HFZ78_RS09705	COG4251	negative regulation of phosphorylation
HFZ78_RS09705	COG3706	GGDEF domain
HFZ78_RS09705	COG2203	Gaf domain
HFZ78_RS09715	COG2211	Major facilitator Superfamily
HFZ78_RS09720	COG2211	Major facilitator Superfamily
HFZ78_RS09725	COG1940	carbohydrate kinase activity
HFZ78_RS09730	COG1904	glucuronate isomerase
HFZ78_RS09735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFZ78_RS09750	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS09765	COG1940	carbohydrate kinase activity
HFZ78_RS09780	COG1606	tRNA processing
HFZ78_RS09785	COG1070	Carbohydrate kinase
HFZ78_RS09790	COG1691	(AIR) carboxylase
HFZ78_RS09795	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HFZ78_RS09800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HFZ78_RS09805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFZ78_RS09815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_RS09825	COG2409	Drug exporters of the RND superfamily
HFZ78_RS09830	COG2390	Transcriptional regulator
HFZ78_RS09835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFZ78_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS09900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_RS09905	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS09925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS09930	COG0306	phosphate transporter
HFZ78_RS09935	COG1392	Phosphate transport regulator
HFZ78_RS09940	COG2261	transglycosylase associated protein
HFZ78_RS09945	COG0564	pseudouridine synthase activity
HFZ78_RS09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFZ78_RS09970	COG2719	SpoVR family
HFZ78_RS09975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_RS09975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_RS09980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ78_RS09980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ78_RS10010	COG1215	transferase activity, transferring glycosyl groups
HFZ78_RS10030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_RS10035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFZ78_RS10040	COG0686	Belongs to the AlaDH PNT family
HFZ78_RS10045	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFZ78_RS10045	COG2508	Transcriptional regulator
HFZ78_RS10050	COG1113	amino acid transport
HFZ78_RS10060	COG1309	transcriptional regulator
HFZ78_RS10065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HFZ78_RS10075	COG2733	membrane
HFZ78_RS10090	COG1253	flavin adenine dinucleotide binding
HFZ78_RS10095	COG1253	flavin adenine dinucleotide binding
HFZ78_RS10100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS10105	COG3852	Histidine kinase
HFZ78_RS10130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_RS10135	COG1132	(ABC) transporter
HFZ78_RS10140	COG1132	(ABC) transporter
HFZ78_RS10145	COG0702	epimerase
HFZ78_RS10165	COG3842	ATPase activity
HFZ78_RS10170	COG2508	Transcriptional regulator
HFZ78_RS10190	COG0189	ligase activity
HFZ78_RS10195	COG0189	ligase activity
HFZ78_RS10205	COG3679	Belongs to the UPF0342 family
HFZ78_RS10210	COG0561	phosphatase activity
HFZ78_RS10215	COG1024	Enoyl-CoA hydratase
HFZ78_RS10225	COG4152	abc transporter atp-binding protein
HFZ78_RS10230	COG1668	transmembrane transport
HFZ78_RS10235	COG0420	3'-5' exonuclease activity
HFZ78_RS10240	COG4717	serine-type aminopeptidase activity
HFZ78_RS10245	COG3481	metal-dependent phosphohydrolase, HD sub domain
HFZ78_RS10255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_RS10280	COG1846	Transcriptional regulator
HFZ78_RS10295	COG0537	adenosine 5'-monophosphoramidase activity
HFZ78_RS10300	COG1131	(ABC) transporter
HFZ78_RS10305	COG4473	ABC transporter
HFZ78_RS10315	COG1473	amidohydrolase
HFZ78_RS10325	COG3069	C4-dicarboxylate transmembrane transporter activity
HFZ78_RS10330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HFZ78_RS10345	COG1511	domain protein
HFZ78_RS10350	COG1234	tRNA 3'-trailer cleavage
HFZ78_RS10355	COG0095	Lipoate-protein ligase
HFZ78_RS10360	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS10365	COG0501	Belongs to the peptidase M48B family
HFZ78_RS10375	COG4903	ComK protein
HFZ78_RS10390	COG0398	Pfam SNARE associated Golgi protein
HFZ78_RS10400	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HFZ78_RS10470	COG0455	bacterial-type flagellum organization
HFZ78_RS10490	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS10515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_RS10525	COG0367	asparagine synthase
HFZ78_RS10530	COG0366	Alpha amylase catalytic
HFZ78_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS10540	COG1666	GTP binding
HFZ78_RS10545	COG2996	Protein conserved in bacteria
HFZ78_RS10555	COG1307	EDD domain protein, DegV family
HFZ78_RS10560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS10575	COG0561	phosphatase activity
HFZ78_RS10580	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ78_RS10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS10595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFZ78_RS10600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HFZ78_RS10605	COG0303	'Molybdopterin
HFZ78_RS10610	COG1763	Mo-molybdopterin cofactor biosynthetic process
HFZ78_RS10620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS10630	COG0542	response to heat
HFZ78_RS10640	COG2267	carboxylic ester hydrolase activity
HFZ78_RS10650	COG1744	ABC transporter substrate-binding protein PnrA-like
HFZ78_RS10660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_RS10670	COG5504	Zn-dependent protease
HFZ78_RS10675	COG0444	Belongs to the ABC transporter superfamily
HFZ78_RS10680	COG4608	Belongs to the ABC transporter superfamily
HFZ78_RS10685	COG0747	negative chemotaxis
HFZ78_RS10690	COG0601	transmembrane transport
HFZ78_RS10695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_RS10705	COG0180	Tryptophanyl-tRNA synthetase
HFZ78_RS10715	COG4166	transmembrane transport
HFZ78_RS10720	COG0601	transmembrane transport
HFZ78_RS10725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_RS10730	COG0444	Belongs to the ABC transporter superfamily
HFZ78_RS10735	COG4608	Belongs to the ABC transporter superfamily
HFZ78_RS10745	COG1393	Belongs to the ArsC family
HFZ78_RS10750	COG4862	establishment of competence for transformation
HFZ78_RS10755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_RS10765	COG1164	Oligoendopeptidase f
HFZ78_RS10775	COG2346	COG2346, Truncated hemoglobins
HFZ78_RS10780	COG4116	CYTH
HFZ78_RS10790	COG2357	RelA SpoT domain protein
HFZ78_RS10800	COG0564	pseudouridine synthase activity
HFZ78_RS10805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFZ78_RS10810	COG0569	domain protein
HFZ78_RS10810	COG0475	glutathione-regulated potassium exporter activity
HFZ78_RS10815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFZ78_RS10850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_RS10870	COG0210	DNA helicase
HFZ78_RS10875	COG2153	protein acetylation
HFZ78_RS10880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HFZ78_RS10885	COG2382	esterase
HFZ78_RS10910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS10920	COG0183	Belongs to the thiolase family
HFZ78_RS10925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_RS10945	COG0456	acetyltransferase
HFZ78_RS10950	COG1509	lysine 2,3-aminomutase activity
HFZ78_RS10960	COG0833	amino acid
HFZ78_RS10965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HFZ78_RS10970	COG0109	protoheme IX farnesyltransferase activity
HFZ78_RS10980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFZ78_RS10985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_RS11000	COG1704	LemA family
HFZ78_RS11010	COG0628	permease
HFZ78_RS11015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HFZ78_RS11045	COG5578	integral membrane protein
HFZ78_RS11050	COG1175	transmembrane transport
HFZ78_RS11065	COG2972	Histidine kinase
HFZ78_RS11080	COG1940	carbohydrate kinase activity
HFZ78_RS11085	COG2222	sugar isomerase
HFZ78_RS11095	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_RS11100	COG3684	Belongs to the aldolase LacD family
HFZ78_RS11105	COG0800	Aldolase
HFZ78_RS11115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HFZ78_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS11145	COG2211	Major facilitator Superfamily
HFZ78_RS11195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS11200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFZ78_RS11235	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_RS11240	COG2267	carboxylic ester hydrolase activity
HFZ78_RS11245	COG4585	Histidine kinase
HFZ78_RS11250	COG2197	response regulator
HFZ78_RS11255	COG2814	Major facilitator Superfamily
HFZ78_RS11260	COG2267	carboxylic ester hydrolase activity
HFZ78_RS11270	COG5002	protein histidine kinase activity
HFZ78_RS11270	COG3850	Histidine kinase
HFZ78_RS11275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFZ78_RS11280	COG0512	Glutamine amidotransferase of anthranilate synthase
HFZ78_RS11285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_RS11290	COG3541	Predicted nucleotidyltransferase
HFZ78_RS11295	COG2372	response to copper ion
HFZ78_RS11295	COG1276	copper resistance
HFZ78_RS11305	COG2364	Membrane
HFZ78_RS11310	COG0436	Aminotransferase
HFZ78_RS11325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HFZ78_RS11345	COG1968	undecaprenyl-diphosphatase activity
HFZ78_RS11355	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_RS11370	COG3339	Conserved Protein
HFZ78_RS11375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_RS11385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFZ78_RS11395	COG1191	sigma factor activity
HFZ78_RS11430	COG1620	l-lactate permease
HFZ78_RS11435	COG2186	Transcriptional regulator
HFZ78_RS11440	COG0247	lactate metabolic process
HFZ78_RS11445	COG1139	Iron-sulfur cluster binding protein
HFZ78_RS11450	COG1556	Lactate utilization protein
HFZ78_RS11460	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFZ78_RS11470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HFZ78_RS11475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ78_RS11480	COG0436	Aminotransferase
HFZ78_RS11485	COG1850	ribulose-bisphosphate carboxylase activity
HFZ78_RS11490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HFZ78_RS11495	COG0235	Class ii aldolase
HFZ78_RS11500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HFZ78_RS11520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_RS11525	COG0644	oxidoreductase
HFZ78_RS11540	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HFZ78_RS11545	COG2223	nitrite transmembrane transporter activity
HFZ78_RS11550	COG1846	Transcriptional regulator
HFZ78_RS11560	COG0542	response to heat
HFZ78_RS11565	COG3949	Membrane
HFZ78_RS11575	COG4873	Protein conserved in bacteria
HFZ78_RS11590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ78_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS11615	COG2084	Dehydrogenase
HFZ78_RS11625	COG0436	Aminotransferase
HFZ78_RS11640	COG1408	metallophosphoesterase
HFZ78_RS11645	COG4990	cell redox homeostasis
HFZ78_RS11650	COG2200	EAL domain
HFZ78_RS11655	COG4703	Protein of unknown function (DUF1797)
HFZ78_RS11660	COG0517	IMP dehydrogenase activity
HFZ78_RS11665	COG0477	Major facilitator Superfamily
HFZ78_RS11670	COG0583	DNA-binding transcription factor activity
HFZ78_RS11675	COG2171	N-acyltransferase activity
HFZ78_RS11680	COG1473	amidohydrolase
HFZ78_RS11685	COG0450	alkyl hydroperoxide reductase
HFZ78_RS11690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS11700	COG0569	domain protein
HFZ78_RS11705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_RS11715	COG0561	phosphatase activity
HFZ78_RS11770	COG1982	Orn Lys Arg decarboxylase major
HFZ78_RS11780	COG4476	Belongs to the UPF0223 family
HFZ78_RS11785	COG4493	Belongs to the UPF0637 family
HFZ78_RS11795	COG0483	inositol monophosphate 1-phosphatase activity
HFZ78_RS11820	COG4896	Protein conserved in bacteria
HFZ78_RS11835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HFZ78_RS11840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ78_RS11845	COG4838	Belongs to the UPF0358 family
HFZ78_RS11850	COG0772	Belongs to the SEDS family
HFZ78_RS11855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFZ78_RS11860	COG1612	heme a metabolic process
HFZ78_RS11865	COG0109	protoheme IX farnesyltransferase activity
HFZ78_RS11890	COG3336	cytochrome c oxidase
HFZ78_RS11905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HFZ78_RS11910	COG2340	Cysteine-rich secretory protein family
HFZ78_RS11940	COG3679	Belongs to the UPF0342 family
HFZ78_RS11945	COG4471	UPF0298 protein
HFZ78_RS11955	COG0742	ribosomal rna small subunit methyltransferase
HFZ78_RS11960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFZ78_RS11965	COG3314	Sporulation integral membrane protein YlbJ
HFZ78_RS11970	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_RS11975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HFZ78_RS11980	COG1323	Belongs to the UPF0348 family
HFZ78_RS11985	COG1399	metal-binding, possibly nucleic acid-binding protein
HFZ78_RS11995	COG1024	Enoyl-CoA hydratase
HFZ78_RS12005	COG0454	-acetyltransferase
HFZ78_RS12010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_RS12015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFZ78_RS12025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HFZ78_RS12030	COG2001	Belongs to the MraZ family
HFZ78_RS12040	COG4839	cell division protein FtsL
HFZ78_RS12050	COG0768	penicillin binding
HFZ78_RS12065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFZ78_RS12070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFZ78_RS12075	COG0772	Belongs to the SEDS family
HFZ78_RS12080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFZ78_RS12085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFZ78_RS12090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFZ78_RS12095	COG3879	Bacterial protein of unknown function (DUF881)
HFZ78_RS12100	COG3879	Bacterial protein of unknown function (DUF881)
HFZ78_RS12105	COG3856	small basic protein
HFZ78_RS12110	COG0849	cell division
HFZ78_RS12115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_RS12125	COG1191	sigma factor activity
HFZ78_RS12130	COG1191	sigma factor activity
HFZ78_RS12135	COG1873	PFAM PRC-barrel domain
HFZ78_RS12145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFZ78_RS12150	COG1799	cell septum assembly
HFZ78_RS12155	COG0762	integral membrane protein
HFZ78_RS12160	COG2302	S4 RNA-binding domain
HFZ78_RS12165	COG3599	regulation of cell shape
HFZ78_RS12170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFZ78_RS12185	COG0564	pseudouridine synthase activity
HFZ78_RS12190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HFZ78_RS12200	COG0540	Belongs to the ATCase OTCase family
HFZ78_RS12215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_RS12225	COG0167	dihydroorotate dehydrogenase activity
HFZ78_RS12230	COG0284	orotidine-5'-phosphate decarboxylase activity
HFZ78_RS12235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HFZ78_RS12245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFZ78_RS12250	COG1561	YicC-like family, N-terminal region
HFZ78_RS12260	COG0194	GDP metabolic process
HFZ78_RS12270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFZ78_RS12275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFZ78_RS12290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFZ78_RS12290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ78_RS12295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFZ78_RS12300	COG0631	protein serine/threonine phosphatase activity
HFZ78_RS12305	COG2815	serine threonine protein kinase
HFZ78_RS12305	COG0515	serine threonine protein kinase
HFZ78_RS12310	COG1162	GTPase activity
HFZ78_RS12315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFZ78_RS12320	COG1564	THIamine pyrophosphokinase
HFZ78_RS12330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFZ78_RS12335	COG1302	Protein conserved in bacteria
HFZ78_RS12340	COG1461	Dihydroxyacetone kinase
HFZ78_RS12345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFZ78_RS12350	COG1349	DNA-binding transcription factor activity
HFZ78_RS12355	COG0416	fatty acid biosynthetic process
HFZ78_RS12360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFZ78_RS12365	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS12380	COG1196	nuclear chromosome segregation
HFZ78_RS12385	COG0552	protein localization to endoplasmic reticulum
HFZ78_RS12390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HFZ78_RS12395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFZ78_RS12405	COG1837	Belongs to the UPF0109 family
HFZ78_RS12415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFZ78_RS12420	COG0336	Belongs to the RNA methyltransferase TrmD family
HFZ78_RS12440	COG1760	l-serine dehydratase
HFZ78_RS12445	COG1760	l-serine dehydratase
HFZ78_RS12460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFZ78_RS12465	COG0758	DNA mediated transformation
HFZ78_RS12470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_RS12475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HFZ78_RS12480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HFZ78_RS12485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HFZ78_RS12490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFZ78_RS12500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFZ78_RS12505	COG0528	UMP kinase activity
HFZ78_RS12510	COG0233	cytoplasmic translational termination
HFZ78_RS12520	COG4589	Belongs to the CDS family
HFZ78_RS12525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HFZ78_RS12530	COG0750	zinc metalloprotease
HFZ78_RS12535	COG2176	DNA-directed DNA polymerase activity
HFZ78_RS12540	COG0779	Required for maturation of 30S ribosomal subunits
HFZ78_RS12545	COG0195	Participates in both transcription termination and antitermination
HFZ78_RS12550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HFZ78_RS12555	COG1358	cellular component organization or biogenesis
HFZ78_RS12565	COG1550	Protein conserved in bacteria
HFZ78_RS12570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFZ78_RS12575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFZ78_RS12580	COG0196	riboflavin kinase activity
HFZ78_RS12585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFZ78_RS12590	COG1185	polyribonucleotide nucleotidyltransferase activity
HFZ78_RS12595	COG0726	polysaccharide deacetylase
HFZ78_RS12600	COG0612	Peptidase, M16
HFZ78_RS12605	COG1873	PFAM PRC-barrel domain
HFZ78_RS12610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_RS12615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFZ78_RS12620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFZ78_RS12625	COG0527	aspartate kinase activity
HFZ78_RS12630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_RS12635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_RS12640	COG0740	serine-type endopeptidase activity
HFZ78_RS12650	COG1674	ftsk spoiiie
HFZ78_RS12650	COG4980	gas vesicle protein
HFZ78_RS12655	COG2188	Transcriptional regulator
HFZ78_RS12680	COG0612	Peptidase, M16
HFZ78_RS12685	COG0612	Peptidase, M16
HFZ78_RS12690	COG0300	oxidoreductase activity
HFZ78_RS12705	COG1426	Protein conserved in bacteria
HFZ78_RS12710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFZ78_RS12715	COG1058	Belongs to the CinA family
HFZ78_RS12715	COG1546	Belongs to the CinA family
HFZ78_RS12720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFZ78_RS12730	COG1692	metallophosphoesterase
HFZ78_RS12735	COG2359	stage V sporulation protein S
HFZ78_RS12740	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFZ78_RS12740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFZ78_RS12745	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFZ78_RS12750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ78_RS12755	COG4550	Control of competence regulator ComK, YlbF/YmcA
HFZ78_RS12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS12775	COG2112	serine threonine protein kinase
HFZ78_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS12795	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS12870	COG1053	succinate dehydrogenase
HFZ78_RS12875	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS12880	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS12885	COG0196	riboflavin kinase activity
HFZ78_RS12895	COG1053	succinate dehydrogenase
HFZ78_RS12900	COG0300	oxidoreductase activity
HFZ78_RS12925	COG2086	electron transfer activity
HFZ78_RS12930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_RS12935	COG1119	ATPase activity
HFZ78_RS12950	COG2972	Histidine kinase
HFZ78_RS12960	COG4213	ABC transporter substrate-binding protein
HFZ78_RS12970	COG4214	carbohydrate transport
HFZ78_RS12975	COG3347	Dehydrogenase
HFZ78_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS12985	COG0697	spore germination
HFZ78_RS12990	COG1070	Carbohydrate kinase
HFZ78_RS12995	COG4806	L-rhamnose isomerase
HFZ78_RS13000	COG1349	DNA-binding transcription factor activity
HFZ78_RS13005	COG3507	Belongs to the glycosyl hydrolase 43 family
HFZ78_RS13015	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS13020	COG2814	Major facilitator Superfamily
HFZ78_RS13030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HFZ78_RS13035	COG2972	Histidine kinase
HFZ78_RS13040	COG2207	Transcriptional regulator
HFZ78_RS13050	COG4209	transmembrane transport
HFZ78_RS13055	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS13060	COG5578	integral membrane protein
HFZ78_RS13065	COG3408	Glycogen debranching enzyme
HFZ78_RS13085	COG2207	Transcriptional regulator
HFZ78_RS13085	COG1917	Cupin 2, conserved barrel domain protein
HFZ78_RS13090	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS13105	COG3959	Transketolase, thiamine diphosphate binding domain
HFZ78_RS13110	COG3958	Transketolase
HFZ78_RS13115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_RS13125	COG0583	DNA-binding transcription factor activity
HFZ78_RS13130	COG0567	Dehydrogenase, E1 component
HFZ78_RS13135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_RS13150	COG0583	DNA-binding transcription factor activity
HFZ78_RS13155	COG0583	DNA-binding transcription factor activity
HFZ78_RS13170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_RS13205	COG1335	isochorismatase
HFZ78_RS13225	COG0346	lactoylglutathione lyase activity
HFZ78_RS13235	COG0400	carboxylic ester hydrolase activity
HFZ78_RS13240	COG2267	carboxylic ester hydrolase activity
HFZ78_RS13255	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS13270	COG5522	Integral membrane protein (intg_mem_TP0381)
HFZ78_RS13275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HFZ78_RS13280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFZ78_RS13285	COG1077	Cell shape determining protein MreB Mrl
HFZ78_RS13290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFZ78_RS13295	COG1923	regulation of RNA biosynthetic process
HFZ78_RS13300	COG0464	growth
HFZ78_RS13305	COG2860	membrane
HFZ78_RS13310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFZ78_RS13320	COG0789	Transcriptional regulator
HFZ78_RS13325	COG0174	glutamine synthetase
HFZ78_RS13335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFZ78_RS13340	COG1388	LysM domain
HFZ78_RS13345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_RS13365	COG3763	UPF0154 protein
HFZ78_RS13370	COG1132	(ABC) transporter
HFZ78_RS13375	COG1132	(ABC) transporter
HFZ78_RS13385	COG0785	Cytochrome C biogenesis protein
HFZ78_RS13390	COG4846	Membrane protein involved in cytochrome C biogenesis
HFZ78_RS13405	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS13465	COG1401	restriction endodeoxyribonuclease activity
HFZ78_RS13470	COG4268	DNA restriction-modification system
HFZ78_RS13510	COG0582	viral genome integration into host DNA
HFZ78_RS13555	COG0778	Nitroreductase
HFZ78_RS13575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_RS13580	COG4224	UPF0291 protein
HFZ78_RS13585	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_RS13615	COG1278	Cold shock
HFZ78_RS13635	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS13700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS13710	COG0697	spore germination
HFZ78_RS13740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFZ78_RS13745	COG0110	maltose O-acetyltransferase activity
HFZ78_RS13760	COG2205	protein histidine kinase activity
HFZ78_RS13765	COG2364	Membrane
HFZ78_RS13770	COG2153	protein acetylation
HFZ78_RS13775	COG1846	Transcriptional regulator
HFZ78_RS13780	COG0456	acetyltransferase
HFZ78_RS13810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HFZ78_RS13825	COG1393	Belongs to the ArsC family
HFZ78_RS13830	COG1846	Transcriptional regulator
HFZ78_RS13835	COG2259	Doxx family
HFZ78_RS13840	COG0346	lactoylglutathione lyase activity
HFZ78_RS13845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS13850	COG0346	lactoylglutathione lyase activity
HFZ78_RS13855	COG0400	carboxylic ester hydrolase activity
HFZ78_RS13860	COG2259	Doxx family
HFZ78_RS13870	COG1741	Belongs to the pirin family
HFZ78_RS13885	COG0583	DNA-binding transcription factor activity
HFZ78_RS13890	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS13895	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS13900	COG1454	alcohol dehydrogenase
HFZ78_RS13905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HFZ78_RS13910	COG2271	Major facilitator Superfamily
HFZ78_RS13925	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_RS13930	COG1024	Enoyl-CoA hydratase
HFZ78_RS13935	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HFZ78_RS13940	COG0457	Tetratricopeptide repeat
HFZ78_RS13945	COG1404	Belongs to the peptidase S8 family
HFZ78_RS13965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_RS13970	COG2323	membrane
HFZ78_RS13980	COG1309	transcriptional regulator
HFZ78_RS13985	COG2814	Major facilitator Superfamily
HFZ78_RS14005	COG2972	Histidine kinase
HFZ78_RS14010	COG3279	Response regulator of the LytR AlgR family
HFZ78_RS14015	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_RS14025	COG3940	Belongs to the glycosyl hydrolase 43 family
HFZ78_RS14030	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_RS14035	COG1129	ABC transporter
HFZ78_RS14040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS14050	COG5492	domain, Protein
HFZ78_RS14105	COG1876	peptidase activity
HFZ78_RS14120	COG1404	Belongs to the peptidase S8 family
HFZ78_RS14130	COG0697	spore germination
HFZ78_RS14135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS14145	COG0583	DNA-binding transcription factor activity
HFZ78_RS14155	COG0583	DNA-binding transcription factor activity
HFZ78_RS14160	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS14170	COG2271	Major facilitator Superfamily
HFZ78_RS14205	COG2271	Major facilitator Superfamily
HFZ78_RS14215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS14220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS14250	COG0583	DNA-binding transcription factor activity
HFZ78_RS14260	COG0583	DNA-binding transcription factor activity
HFZ78_RS14265	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS14275	COG0596	Alpha beta hydrolase
HFZ78_RS14290	COG2271	Major facilitator Superfamily
HFZ78_RS14305	COG0583	DNA-binding transcription factor activity
HFZ78_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS14320	COG0300	oxidoreductase activity
HFZ78_RS14325	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS14330	COG2030	dehydratase
HFZ78_RS14340	COG2086	electron transfer activity
HFZ78_RS14345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_RS14350	COG0439	Biotin carboxylase
HFZ78_RS14355	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_RS14360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_RS14370	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_RS14375	COG5002	protein histidine kinase activity
HFZ78_RS14390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS14390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS14395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS14395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS14400	COG0183	Belongs to the thiolase family
HFZ78_RS14440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_RS14455	COG1573	uracil-dna glycosylase
HFZ78_RS14480	COG3835	regulator
HFZ78_RS14485	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS14490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_RS14495	COG0439	Biotin carboxylase
HFZ78_RS14500	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_RS14505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_RS14510	COG1024	Enoyl-CoA hydratase
HFZ78_RS14515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_RS14520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS14525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS14530	COG2094	Belongs to the DNA glycosylase MPG family
HFZ78_RS14545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_RS14550	COG1609	Transcriptional regulator
HFZ78_RS14590	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_RS14610	COG1175	transmembrane transport
HFZ78_RS14625	COG2972	Histidine kinase
HFZ78_RS14630	COG2207	Transcriptional regulator
HFZ78_RS14630	COG4753	response regulator
HFZ78_RS14640	COG1113	amino acid transport
HFZ78_RS14645	COG2814	Major facilitator Superfamily
HFZ78_RS14655	COG2188	Transcriptional regulator
HFZ78_RS14660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_RS14665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_RS14670	COG1486	melibiose metabolic process
HFZ78_RS14675	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_RS14705	COG1396	sequence-specific DNA binding
HFZ78_RS14710	COG0252	asparaginase activity
HFZ78_RS14720	COG2755	lipolytic protein G-D-S-L family
HFZ78_RS14725	COG3290	protein histidine kinase activity
HFZ78_RS14730	COG4565	transcriptional regulatory protein
HFZ78_RS14735	COG2851	Citrate transporter
HFZ78_RS14760	COG2814	Major facilitator Superfamily
HFZ78_RS14765	COG2368	4-hydroxyphenylacetate
HFZ78_RS14770	COG0196	riboflavin kinase activity
HFZ78_RS14775	COG0431	NADPH-dependent FMN reductase
HFZ78_RS14800	COG3971	2-oxopent-4-enoate hydratase activity
HFZ78_RS14810	COG3844	kynureninase activity
HFZ78_RS14815	COG1113	amino acid transport
HFZ78_RS14820	COG3483	tryptophan 2,3-dioxygenase activity
HFZ78_RS14825	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_RS14835	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_RS14850	COG1533	DNA photolyase activity
HFZ78_RS14855	COG0477	Major facilitator Superfamily
HFZ78_RS14860	COG1309	transcriptional regulator
HFZ78_RS14865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ78_RS14870	COG1368	sulfuric ester hydrolase activity
HFZ78_RS14880	COG0697	spore germination
HFZ78_RS14905	COG0175	sulfate reduction
HFZ78_RS14910	COG0306	phosphate transporter
HFZ78_RS14920	COG0529	Catalyzes the synthesis of activated sulfate
HFZ78_RS14930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS14935	COG2814	Major facilitator Superfamily
HFZ78_RS14940	COG1846	Transcriptional regulator
HFZ78_RS14945	COG1027	Aspartate ammonia-lyase
HFZ78_RS14955	COG2720	vancomycin resistance protein
HFZ78_RS14965	COG3829	transcription factor binding
HFZ78_RS14970	COG0833	amino acid
HFZ78_RS14980	COG1695	Transcriptional regulator
HFZ78_RS15010	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_RS15030	COG0419	ATPase involved in DNA repair
HFZ78_RS15060	COG2310	stress, protein
HFZ78_RS15065	COG1033	growth of symbiont in host cell
HFZ78_RS15065	COG2409	Drug exporters of the RND superfamily
HFZ78_RS15070	COG1846	Transcriptional regulator
HFZ78_RS15080	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS15085	COG5002	protein histidine kinase activity
HFZ78_RS15095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFZ78_RS15110	COG2304	oxidoreductase activity
HFZ78_RS15135	COG1131	(ABC) transporter
HFZ78_RS15140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_RS15155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_RS15160	COG1363	Peptidase, m42
HFZ78_RS15170	COG0598	Magnesium transport protein CorA
HFZ78_RS15180	COG0791	NLP P60 protein
HFZ78_RS15180	COG1388	LysM domain
HFZ78_RS15185	COG0398	Pfam SNARE associated Golgi protein
HFZ78_RS15200	COG1272	protein, Hemolysin III
HFZ78_RS15205	COG0477	Major facilitator Superfamily
HFZ78_RS15210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ78_RS15220	COG2080	2 iron, 2 sulfur cluster binding
HFZ78_RS15230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFZ78_RS15235	COG0861	Integral membrane protein TerC family
HFZ78_RS15240	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_RS15245	COG1183	phosphatidylcholine synthase activity
HFZ78_RS15250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFZ78_RS15255	COG1845	cytochrome c oxidase, subunit III
HFZ78_RS15260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_RS15275	COG0071	Belongs to the small heat shock protein (HSP20) family
HFZ78_RS15290	COG0561	phosphatase activity
HFZ78_RS15295	COG1278	Cold shock
HFZ78_RS15300	COG4895	conserved protein (DUF2196)
HFZ78_RS15310	COG0753	catalase activity
HFZ78_RS15320	COG0307	riboflavin synthase, alpha
HFZ78_RS15325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_RS15325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_RS15330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HFZ78_RS15335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_RS15340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS15345	COG1120	ATPase activity
HFZ78_RS15350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HFZ78_RS15355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ78_RS15360	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HFZ78_RS15365	COG1492	cobalamin metabolic process
HFZ78_RS15370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HFZ78_RS15385	COG2096	Adenosyltransferase
HFZ78_RS15400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_RS15405	COG1136	(ABC) transporter
HFZ78_RS15410	COG0577	efflux transmembrane transporter activity
HFZ78_RS15420	COG2211	Major facilitator Superfamily
HFZ78_RS15435	COG0697	spore germination
HFZ78_RS15445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS15450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS15455	COG5002	protein histidine kinase activity
HFZ78_RS15460	COG1247	-acetyltransferase
HFZ78_RS15480	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS15505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFZ78_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS15515	COG0183	Belongs to the thiolase family
HFZ78_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS15555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_RS15560	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS15565	COG1454	alcohol dehydrogenase
HFZ78_RS15575	COG1227	inorganic diphosphatase activity
HFZ78_RS15580	COG2233	PERMEase
HFZ78_RS15590	COG0561	phosphatase activity
HFZ78_RS15605	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ78_RS15625	COG2357	RelA SpoT domain protein
HFZ78_RS15630	COG0516	GMP reductase activity
HFZ78_RS15630	COG0517	IMP dehydrogenase activity
HFZ78_RS15640	COG1408	metallophosphoesterase
HFZ78_RS15660	COG2270	Major facilitator Superfamily
HFZ78_RS15690	COG3290	protein histidine kinase activity
HFZ78_RS15695	COG4565	transcriptional regulatory protein
HFZ78_RS15715	COG0322	excinuclease ABC activity
HFZ78_RS15720	COG2310	stress, protein
HFZ78_RS15740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HFZ78_RS15745	COG1228	amidohydrolase
HFZ78_RS15750	COG0010	Belongs to the arginase family
HFZ78_RS15760	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_RS15770	COG4191	Histidine kinase
HFZ78_RS15775	COG2204	response regulator
HFZ78_RS15850	COG1301	dicarboxylic acid transport
HFZ78_RS15860	COG3290	protein histidine kinase activity
HFZ78_RS15870	COG0351	phosphomethylpyrimidine kinase
HFZ78_RS15885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_RS15890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFZ78_RS15895	COG1116	anion transmembrane transporter activity
HFZ78_RS15900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_RS15905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_RS15930	COG1278	Cold shock
HFZ78_RS15940	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_RS15950	COG0640	Transcriptional regulator
HFZ78_RS15955	COG0534	Mate efflux family protein
HFZ78_RS15975	COG1609	Transcriptional regulator
HFZ78_RS15980	COG1263	PTS System
HFZ78_RS15980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS15985	COG1621	beta-fructofuranosidase activity
HFZ78_RS16000	COG0454	-acetyltransferase
HFZ78_RS16005	COG4319	ketosteroid isomerase
HFZ78_RS16010	COG2329	Antibiotic biosynthesis monooxygenase
HFZ78_RS16035	COG1349	DNA-binding transcription factor activity
HFZ78_RS16040	COG4549	nuclear export factor GLE1
HFZ78_RS16050	COG3180	Ammonia monooxygenase
HFZ78_RS16075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFZ78_RS16085	COG3883	PFAM NLP P60 protein
HFZ78_RS16085	COG0791	NLP P60 protein
HFZ78_RS16100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_RS16125	COG0326	Molecular chaperone. Has ATPase activity
HFZ78_RS16130	COG0346	lactoylglutathione lyase activity
HFZ78_RS16135	COG0667	Aldo Keto reductase
HFZ78_RS16145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_RS16150	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFZ78_RS16155	COG1687	branched-chain amino acid
HFZ78_RS16170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ78_RS16175	COG0431	NADPH-dependent FMN reductase
HFZ78_RS16180	COG0196	riboflavin kinase activity
HFZ78_RS16190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_RS16220	COG0531	amino acid
HFZ78_RS16225	COG0583	DNA-binding transcription factor activity
HFZ78_RS16230	COG0697	spore germination
HFZ78_RS16235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_RS16240	COG1522	sequence-specific DNA binding
HFZ78_RS16280	COG1609	Transcriptional regulator
HFZ78_RS16290	COG0720	synthase
HFZ78_RS16295	COG0602	queuosine metabolic process
HFZ78_RS16305	COG0352	thiamine-phosphate diphosphorylase activity
HFZ78_RS16310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_RS16315	COG2104	thiamine diphosphate biosynthetic process
HFZ78_RS16320	COG2022	thiamine diphosphate biosynthetic process
HFZ78_RS16325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_RS16340	COG0586	Pfam SNARE associated Golgi protein
HFZ78_RS16365	COG0730	response to heat
HFZ78_RS16395	COG3655	Transcriptional regulator
HFZ78_RS16400	COG1309	transcriptional regulator
HFZ78_RS16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_RS16420	COG0702	epimerase
HFZ78_RS16430	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ78_RS16430	COG3848	Pyruvate phosphate dikinase
HFZ78_RS16440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFZ78_RS16485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS16495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_RS16530	COG2207	Transcriptional regulator
HFZ78_RS16545	COG4978	Transcriptional regulator
HFZ78_RS16545	COG0789	Transcriptional regulator
HFZ78_RS16550	COG1811	Na channel or pump
HFZ78_RS16555	COG1335	isochorismatase
HFZ78_RS16560	COG0702	epimerase
HFZ78_RS16585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_RS16590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS16595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS16600	COG3338	carbonate dehydratase activity
HFZ78_RS16610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ78_RS16620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HFZ78_RS16625	COG3608	succinylglutamate desuccinylase aspartoacylase
HFZ78_RS16625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ78_RS16630	COG0789	Transcriptional regulator
HFZ78_RS16635	COG1064	alcohol dehydrogenase
HFZ78_RS16640	COG0583	DNA-binding transcription factor activity
HFZ78_RS16645	COG4221	oxidoreductase activity
HFZ78_RS16670	COG2814	Major facilitator Superfamily
HFZ78_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS16680	COG1064	alcohol dehydrogenase
HFZ78_RS16690	COG0110	maltose O-acetyltransferase activity
HFZ78_RS16700	COG1309	transcriptional regulator
HFZ78_RS16705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFZ78_RS16710	COG2814	Major facilitator Superfamily
HFZ78_RS16730	COG0165	Argininosuccinate lyase
HFZ78_RS16740	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS16750	COG2267	carboxylic ester hydrolase activity
HFZ78_RS16800	COG2801	Transposase and inactivated derivatives
HFZ78_RS16825	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS16830	COG0110	maltose O-acetyltransferase activity
HFZ78_RS16845	COG2169	Transcriptional regulator
HFZ78_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS16885	COG4585	Histidine kinase
HFZ78_RS16890	COG2197	response regulator
HFZ78_RS16895	COG2211	Major facilitator Superfamily
HFZ78_RS16900	COG2207	Transcriptional regulator
HFZ78_RS16905	COG2723	6-phospho-beta-galactosidase activity
HFZ78_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS16915	COG3250	beta-galactosidase activity
HFZ78_RS16920	COG4977	sequence-specific DNA binding
HFZ78_RS16925	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS16960	COG2197	response regulator
HFZ78_RS16980	COG0697	spore germination
HFZ78_RS16985	COG0814	amino acid
HFZ78_RS17010	COG1309	transcriptional regulator
HFZ78_RS17025	COG4978	Transcriptional regulator
HFZ78_RS17025	COG0789	Transcriptional regulator
HFZ78_RS17030	COG2814	Major facilitator Superfamily
HFZ78_RS17035	COG2323	membrane
HFZ78_RS17050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_RS17075	COG1335	isochorismatase
HFZ78_RS17125	COG1846	Transcriptional regulator
HFZ78_RS17145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ78_RS17170	COG5002	protein histidine kinase activity
HFZ78_RS17200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFZ78_RS17220	COG0583	DNA-binding transcription factor activity
HFZ78_RS17230	COG0697	spore germination
HFZ78_RS17265	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFZ78_RS17270	COG3052	prosthetic group binding
HFZ78_RS17285	COG2364	Membrane
HFZ78_RS17290	COG1846	Transcriptional regulator
HFZ78_RS17295	COG0456	acetyltransferase
HFZ78_RS17300	COG2808	Putative FMN-binding domain
HFZ78_RS17365	COG1113	amino acid transport
HFZ78_RS17405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS17420	COG1846	Transcriptional regulator
HFZ78_RS17425	COG2259	Doxx family
HFZ78_RS17430	COG0346	lactoylglutathione lyase activity
HFZ78_RS17435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS17445	COG0400	carboxylic ester hydrolase activity
HFZ78_RS17450	COG2259	Doxx family
HFZ78_RS17455	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_RS17525	COG2323	membrane
HFZ78_RS17550	COG0412	Dienelactone hydrolase
HFZ78_RS17565	COG1247	-acetyltransferase
HFZ78_RS17575	COG0222	ribosome binding
HFZ78_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS17605	COG2076	Multidrug Resistance protein
HFZ78_RS17610	COG2076	Multidrug Resistance protein
HFZ78_RS17615	COG1388	LysM domain
HFZ78_RS17615	COG3942	CHAP domain
HFZ78_RS17645	COG0589	response to stress
HFZ78_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS17665	COG0604	alcohol dehydrogenase
HFZ78_RS17665	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS17665	COG3321	synthase
HFZ78_RS17670	COG0747	negative chemotaxis
HFZ78_RS17675	COG0601	transmembrane transport
HFZ78_RS17680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_RS17685	COG0444	Belongs to the ABC transporter superfamily
HFZ78_RS17690	COG4608	Belongs to the ABC transporter superfamily
HFZ78_RS17695	COG0534	Mate efflux family protein
HFZ78_RS17765	COG1492	cobalamin metabolic process
HFZ78_RS17770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFZ78_RS17775	COG1587	Uroporphyrinogen-III synthase
HFZ78_RS17775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFZ78_RS17785	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HFZ78_RS17800	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HFZ78_RS17805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFZ78_RS17810	COG1473	amidohydrolase
HFZ78_RS17820	COG0701	Predicted permease
HFZ78_RS17865	COG1937	Protein conserved in bacteria
HFZ78_RS17870	COG2608	mercury ion transmembrane transporter activity
HFZ78_RS17880	COG2217	Heavy metal translocating P-type atpase
HFZ78_RS17895	COG0789	Transcriptional regulator
HFZ78_RS17895	COG4978	Transcriptional regulator
HFZ78_RS17900	COG0531	amino acid
HFZ78_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS17925	COG2271	Major facilitator Superfamily
HFZ78_RS17945	COG0460	homoserine dehydrogenase
HFZ78_RS17950	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS17955	COG0833	amino acid
HFZ78_RS17960	COG1823	symporter activity
HFZ78_RS17985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_RS18015	COG3443	Belongs to the bacterial solute-binding protein 9 family
HFZ78_RS18055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_RS18060	COG0523	cobalamin synthesis protein
HFZ78_RS18070	COG0701	Predicted permease
HFZ78_RS18075	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_RS18120	COG1175	transmembrane transport
HFZ78_RS18135	COG2207	Transcriptional regulator
HFZ78_RS18135	COG4753	response regulator
HFZ78_RS18160	COG0019	diaminopimelate decarboxylase activity
HFZ78_RS18180	COG0640	Transcriptional regulator
HFZ78_RS18190	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HFZ78_RS18195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_RS18200	COG0156	8-amino-7-oxononanoate synthase activity
HFZ78_RS18215	COG1988	membrane-bound metal-dependent
HFZ78_RS18245	COG0202	RNA polymerase activity
HFZ78_RS18280	COG2801	Transposase and inactivated derivatives
HFZ78_RS18305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFZ78_RS18330	COG0523	cobalamin synthesis protein
HFZ78_RS18335	COG0523	cobalamin synthesis protein
HFZ78_RS18340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_RS18350	COG1469	GTP cyclohydrolase I activity
HFZ78_RS18380	COG4303	Ethanolamine ammonia lyase large subunit
HFZ78_RS18385	COG4302	ethanolamine ammonia-lyase activity
HFZ78_RS18395	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS18395	COG1454	alcohol dehydrogenase
HFZ78_RS18410	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HFZ78_RS18415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HFZ78_RS18420	COG0039	L-malate dehydrogenase activity
HFZ78_RS18425	COG0531	amino acid
HFZ78_RS18430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_RS18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_RS18450	COG0084	hydrolase, TatD family'
HFZ78_RS18520	COG1525	nuclease
HFZ78_RS18530	COG1393	Belongs to the ArsC family
HFZ78_RS18570	COG2169	Transcriptional regulator
HFZ78_RS18570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFZ78_RS18615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_RS18625	COG0305	Participates in initiation and elongation during chromosome replication
HFZ78_RS18650	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS18775	COG1401	restriction endodeoxyribonuclease activity
HFZ78_RS18790	COG1074	ATP-dependent DNA helicase activity
HFZ78_RS18805	COG0210	DNA helicase
HFZ78_RS18820	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_RS18825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFZ78_RS18865	COG1309	transcriptional regulator
HFZ78_RS18870	COG3118	belongs to the thioredoxin family
HFZ78_RS18910	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS18915	COG1404	Belongs to the peptidase S8 family
HFZ78_RS18915	COG4412	M6 family metalloprotease domain protein
HFZ78_RS18920	COG0583	DNA-binding transcription factor activity
HFZ78_RS18935	COG2188	Transcriptional regulator
HFZ78_RS18940	COG1840	ABC-type Fe3 transport system, periplasmic component
HFZ78_RS18950	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ78_RS18955	COG1177	transmembrane transport
HFZ78_RS18975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_RS18985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS18995	COG0069	glutamate synthase activity
HFZ78_RS18995	COG0067	glutamate synthase
HFZ78_RS18995	COG0070	glutamate synthase
HFZ78_RS19000	COG0493	'glutamate synthase
HFZ78_RS19005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_RS19010	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_RS19015	COG2116	formate transmembrane transporter activity
HFZ78_RS19025	COG2814	Major facilitator Superfamily
HFZ78_RS19055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_RS19065	COG0697	spore germination
HFZ78_RS19080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS19090	COG2801	Transposase and inactivated derivatives
HFZ78_RS19095	COG0506	proline dehydrogenase activity
HFZ78_RS19100	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS19105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS19135	COG1733	regulation of RNA biosynthetic process
HFZ78_RS19140	COG0778	Nitroreductase
HFZ78_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS19180	COG4221	oxidoreductase activity
HFZ78_RS19185	COG2207	Transcriptional regulator
HFZ78_RS19215	COG2085	NADP oxidoreductase coenzyme F420-dependent
HFZ78_RS19220	COG1733	regulation of RNA biosynthetic process
HFZ78_RS19225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_RS19270	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HFZ78_RS19385	COG0640	Transcriptional regulator
HFZ78_RS19400	COG0242	peptide deformylase activity
HFZ78_RS19415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_RS19425	COG0583	DNA-binding transcription factor activity
HFZ78_RS19430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_RS19430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_RS19440	COG1301	dicarboxylic acid transport
HFZ78_RS19470	COG2318	DinB family
HFZ78_RS19475	COG2318	DinB family
HFZ78_RS19510	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS19515	COG2814	Major facilitator Superfamily
HFZ78_RS19555	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_RS19560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS19560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS19560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS19565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS19570	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS19575	COG0069	glutamate synthase activity
HFZ78_RS19580	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS19640	COG1942	4-Oxalocrotonate Tautomerase
HFZ78_RS19695	COG0583	DNA-binding transcription factor activity
HFZ78_RS19705	COG0456	acetyltransferase
HFZ78_RS19715	COG2315	Protein conserved in bacteria
HFZ78_RS19735	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HFZ78_RS19740	COG5002	protein histidine kinase activity
HFZ78_RS19750	COG0583	DNA-binding transcription factor activity
HFZ78_RS19755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS19775	COG0789	Transcriptional regulator
HFZ78_RS19780	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS19785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFZ78_RS19800	COG0697	spore germination
HFZ78_RS19805	COG3275	phosphorelay sensor kinase activity
HFZ78_RS19810	COG3279	Response regulator of the LytR AlgR family
HFZ78_RS19815	COG2223	nitrite transmembrane transporter activity
HFZ78_RS19825	COG0697	spore germination
HFZ78_RS19865	COG5001	Diguanylate cyclase
HFZ78_RS19880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFZ78_RS19900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HFZ78_RS19930	COG0531	amino acid
HFZ78_RS19935	COG0697	spore germination
HFZ78_RS19995	COG2318	DinB family
HFZ78_RS20010	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS20015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS20020	COG0583	DNA-binding transcription factor activity
HFZ78_RS20030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFZ78_RS20045	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS20060	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS20065	COG0789	Transcriptional regulator
HFZ78_RS20130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_RS20140	COG3655	Transcriptional regulator
HFZ78_RS20150	COG0517	IMP dehydrogenase activity
HFZ78_RS20160	COG3773	Cell wall hydrolase
HFZ78_RS20165	COG0493	'glutamate synthase
HFZ78_RS20170	COG0167	dihydroorotate dehydrogenase activity
HFZ78_RS20195	COG3835	regulator
HFZ78_RS20200	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS20205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_RS20230	COG0400	carboxylic ester hydrolase activity
HFZ78_RS20235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HFZ78_RS20240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFZ78_RS20255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_RS20260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_RS20305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_RS20305	COG0596	Alpha beta hydrolase
HFZ78_RS20315	COG2259	Doxx family
HFZ78_RS20320	COG3384	dioxygenase
HFZ78_RS20335	COG3858	chitin binding
HFZ78_RS20345	COG1164	Oligoendopeptidase f
HFZ78_RS20355	COG1215	transferase activity, transferring glycosyl groups
HFZ78_RS20355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HFZ78_RS20375	COG0714	Associated with various cellular activities
HFZ78_RS20390	COG1714	RDD family
HFZ78_RS20410	COG0477	Major facilitator Superfamily
HFZ78_RS20420	COG1309	transcriptional regulator
HFZ78_RS20430	COG2814	Major facilitator Superfamily
HFZ78_RS20440	COG2207	Transcriptional regulator
HFZ78_RS20450	COG0656	L-ascorbic acid biosynthetic process
HFZ78_RS20465	COG1309	transcriptional regulator
HFZ78_RS20470	COG0534	Mate efflux family protein
HFZ78_RS20525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ78_RS20530	COG0187	DNA topoisomerase II activity
HFZ78_RS20535	COG1832	CoA-binding protein
HFZ78_RS20550	COG4753	response regulator
HFZ78_RS20550	COG2207	Transcriptional regulator
HFZ78_RS20555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HFZ78_RS20575	COG0824	Thioesterase
HFZ78_RS20580	COG0464	growth
HFZ78_RS20600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS20605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HFZ78_RS20620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFZ78_RS20660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS20680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_RS20685	COG2233	PERMEase
HFZ78_RS20695	COG2233	PERMEase
HFZ78_RS20700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS20715	COG0488	(ABC) transporter
HFZ78_RS20725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HFZ78_RS20730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFZ78_RS20735	COG3639	organic phosphonate transmembrane transporter activity
HFZ78_RS20750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS20765	COG0701	Predicted permease
HFZ78_RS20770	COG3689	TIGRFAM TIGR03943 family protein
HFZ78_RS20775	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_RS20780	COG0701	Predicted permease
HFZ78_RS20795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_RS20805	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS20810	COG1215	transferase activity, transferring glycosyl groups
HFZ78_RS20815	COG3206	protein involved in exopolysaccharide biosynthesis
HFZ78_RS20820	COG3307	-O-antigen
HFZ78_RS20825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS20830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_RS20835	COG0297	glycogen (starch) synthase activity
HFZ78_RS20835	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS20840	COG2244	polysaccharide biosynthetic process
HFZ78_RS20850	COG1253	flavin adenine dinucleotide binding
HFZ78_RS20855	COG0789	Transcriptional regulator
HFZ78_RS20860	COG0024	Methionine aminopeptidase
HFZ78_RS20880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_RS20890	COG5337	Spore coat protein CotH
HFZ78_RS20915	COG3011	Protein conserved in bacteria
HFZ78_RS20935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS20935	COG1263	PTS System
HFZ78_RS20940	COG0366	Alpha amylase catalytic
HFZ78_RS20945	COG2188	Transcriptional regulator
HFZ78_RS20950	COG2135	peptidase activity
HFZ78_RS20955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFZ78_RS20965	COG0456	acetyltransferase
HFZ78_RS21005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFZ78_RS21015	COG0697	spore germination
HFZ78_RS21025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFZ78_RS21030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HFZ78_RS21040	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_RS21045	COG0765	amino acid transport
HFZ78_RS21050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS21055	COG1126	abc transporter atp-binding protein
HFZ78_RS21060	COG3829	transcription factor binding
HFZ78_RS21070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS21075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_RS21080	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS21090	COG0477	Major facilitator Superfamily
HFZ78_RS21095	COG5002	protein histidine kinase activity
HFZ78_RS21105	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_RS21110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_RS21115	COG0243	molybdopterin cofactor binding
HFZ78_RS21120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_RS21125	COG2223	nitrite transmembrane transporter activity
HFZ78_RS21140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS21145	COG0529	Catalyzes the synthesis of activated sulfate
HFZ78_RS21150	COG2046	Belongs to the sulfate adenylyltransferase family
HFZ78_RS21155	COG0175	sulfate reduction
HFZ78_RS21165	COG1809	phosphosulfolactate synthase activity
HFZ78_RS21170	COG2814	Major facilitator Superfamily
HFZ78_RS21180	COG0730	response to heat
HFZ78_RS21185	COG0697	spore germination
HFZ78_RS21210	COG1357	PFAM Pentapeptide repeats (8 copies)
HFZ78_RS21220	COG0861	Integral membrane protein TerC family
HFZ78_RS21245	COG1522	sequence-specific DNA binding
HFZ78_RS21245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS21255	COG1247	-acetyltransferase
HFZ78_RS21265	COG2329	Antibiotic biosynthesis monooxygenase
HFZ78_RS21280	COG0183	Belongs to the thiolase family
HFZ78_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS21295	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS21300	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_RS21315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_RS21320	COG1231	oxidoreductase activity
HFZ78_RS21335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_RS21345	COG1216	Glycosyl transferase, family 2
HFZ78_RS21355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_RS21360	COG1279	arginine transmembrane transporter activity
HFZ78_RS21365	COG0604	alcohol dehydrogenase
HFZ78_RS21375	COG0477	Major facilitator Superfamily
HFZ78_RS21395	COG0697	spore germination
HFZ78_RS21400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS21405	COG4932	domain protein
HFZ78_RS21405	COG1388	LysM domain
HFZ78_RS21410	COG4191	Histidine kinase
HFZ78_RS21430	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_RS21445	COG0561	phosphatase activity
HFZ78_RS21465	COG0668	transmembrane transport
HFZ78_RS21490	COG1378	Sugar-specific transcriptional regulator TrmB
HFZ78_RS21495	COG1280	lysine exporter protein (LysE YggA)
HFZ78_RS21510	COG1733	regulation of RNA biosynthetic process
HFZ78_RS21520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ78_RS21540	COG1280	lysine exporter protein (LysE YggA)
HFZ78_RS21560	COG1587	Uroporphyrinogen-III synthase
HFZ78_RS21585	COG2814	Major facilitator Superfamily
HFZ78_RS21600	COG1346	cytolysis
HFZ78_RS21605	COG1380	Effector of murein hydrolase LrgA
HFZ78_RS21615	COG0716	FMN binding
HFZ78_RS21620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_RS21625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_RS21630	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_RS21630	COG4085	toxin activity
HFZ78_RS21630	COG1525	nuclease
HFZ78_RS21635	COG2720	vancomycin resistance protein
HFZ78_RS21640	COG2116	formate transmembrane transporter activity
HFZ78_RS21645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFZ78_RS21650	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_RS21660	COG0506	proline dehydrogenase activity
HFZ78_RS21665	COG2186	Transcriptional regulator
HFZ78_RS21670	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_RS21680	COG2084	Dehydrogenase
HFZ78_RS21685	COG2610	gluconate transmembrane transporter activity
HFZ78_RS21690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_RS21695	COG3835	regulator
HFZ78_RS21705	COG1098	S1 RNA binding domain
HFZ78_RS21710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_RS21715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_RS21720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_RS21725	COG2318	DinB family
HFZ78_RS21735	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS21735	COG1454	alcohol dehydrogenase
HFZ78_RS21755	COG0765	amino acid transport
HFZ78_RS21760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS21765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFZ78_RS21775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_RS21860	COG1802	Transcriptional regulator
HFZ78_RS21865	COG2059	Chromate
HFZ78_RS21870	COG2059	Chromate
HFZ78_RS21915	COG3069	C4-dicarboxylate transmembrane transporter activity
HFZ78_RS21920	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HFZ78_RS21940	COG0306	phosphate transporter
HFZ78_RS21945	COG2072	flavoprotein involved in K transport
HFZ78_RS21955	COG2197	response regulator
HFZ78_RS21960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS21985	COG0028	Belongs to the TPP enzyme family
HFZ78_RS21995	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_RS22000	COG1289	transmembrane transporter activity
HFZ78_RS22005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFZ78_RS22045	COG2226	methyltransferase
HFZ78_RS22055	COG1116	anion transmembrane transporter activity
HFZ78_RS22060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_RS22065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_RS22095	COG0788	formyltetrahydrofolate deformylase activity
HFZ78_RS22110	COG0534	Mate efflux family protein
HFZ78_RS22115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_RS22120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFZ78_RS22125	COG2070	2-Nitropropane dioxygenase
HFZ78_RS22165	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS22170	COG3118	belongs to the thioredoxin family
HFZ78_RS22190	COG0493	'glutamate synthase
HFZ78_RS22195	COG0070	glutamate synthase
HFZ78_RS22195	COG0069	glutamate synthase activity
HFZ78_RS22195	COG0067	glutamate synthase
HFZ78_RS22200	COG0583	DNA-binding transcription factor activity
HFZ78_RS22205	COG0151	Belongs to the GarS family
HFZ78_RS22210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFZ78_RS22215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HFZ78_RS22220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_RS22225	COG0047	phosphoribosylformylglycinamidine synthase activity
HFZ78_RS22230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_RS22235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFZ78_RS22240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFZ78_RS22245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFZ78_RS22260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_RS22280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ78_RS22285	COG1414	Transcriptional regulator
HFZ78_RS22290	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS22305	COG0788	formyltetrahydrofolate deformylase activity
HFZ78_RS22310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ78_RS22320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFZ78_RS22325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_RS22330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_RS22335	COG0509	glycine decarboxylation via glycine cleavage system
HFZ78_RS22345	COG1760	l-serine dehydratase
HFZ78_RS22350	COG1760	l-serine dehydratase
HFZ78_RS22355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFZ78_RS22360	COG1113	amino acid transport
HFZ78_RS22375	COG4753	response regulator
HFZ78_RS22375	COG2207	Transcriptional regulator
HFZ78_RS22380	COG2972	Histidine kinase
HFZ78_RS22385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ78_RS22405	COG0531	amino acid
HFZ78_RS22410	COG0697	spore germination
HFZ78_RS22435	COG1733	regulation of RNA biosynthetic process
HFZ78_RS22445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_RS22455	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS22465	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_RS22475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_RS22540	COG1126	abc transporter atp-binding protein
HFZ78_RS22545	COG0765	amino acid transport
HFZ78_RS22550	COG0765	amino acid transport
HFZ78_RS22555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS22570	COG2828	Protein conserved in bacteria
HFZ78_RS22575	COG0583	DNA-binding transcription factor activity
HFZ78_RS22590	COG3180	Ammonia monooxygenase
HFZ78_RS22595	COG0583	DNA-binding transcription factor activity
HFZ78_RS22600	COG1053	succinate dehydrogenase
HFZ78_RS22610	COG3103	Sh3 type 3 domain protein
HFZ78_RS22610	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_RS22610	COG4991	sh3 domain protein
HFZ78_RS22615	COG0523	cobalamin synthesis protein
HFZ78_RS22625	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFZ78_RS22630	COG0717	Belongs to the dCTP deaminase family
HFZ78_RS22635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_RS22650	COG3411	Ferredoxin
HFZ78_RS22655	COG0523	cobalamin synthesis protein
HFZ78_RS22660	COG0822	iron-sulfur transferase activity
HFZ78_RS22670	COG0701	Predicted permease
HFZ78_RS22675	COG1121	(ABC) transporter
HFZ78_RS22680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ78_RS22685	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_RS22690	COG0735	belongs to the Fur family
HFZ78_RS22725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_RS22745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS22750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS22755	COG0604	alcohol dehydrogenase
HFZ78_RS22760	COG2814	Major facilitator Superfamily
HFZ78_RS22765	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS22780	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_RS22790	COG1846	Transcriptional regulator
HFZ78_RS22795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS22820	COG1404	Belongs to the peptidase S8 family
HFZ78_RS22825	COG0583	DNA-binding transcription factor activity
HFZ78_RS22830	COG1876	peptidase activity
HFZ78_RS22845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_RS22890	COG1764	response to oxidative stress
HFZ78_RS22895	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_RS22900	COG0400	carboxylic ester hydrolase activity
HFZ78_RS22910	COG0346	lactoylglutathione lyase activity
HFZ78_RS22915	COG1846	Transcriptional regulator
HFZ78_RS22920	COG1393	Belongs to the ArsC family
HFZ78_RS22930	COG1388	LysM domain
HFZ78_RS22930	COG3858	chitin binding
HFZ78_RS22940	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_RS22950	COG0346	lactoylglutathione lyase activity
HFZ78_RS22960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_RS22970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFZ78_RS22985	COG1914	H( )-stimulated, divalent metal cation uptake system
HFZ78_RS22995	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HFZ78_RS23015	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HFZ78_RS23025	COG5002	protein histidine kinase activity
HFZ78_RS23045	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFZ78_RS23065	COG0778	Nitroreductase
HFZ78_RS23070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_RS23075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HFZ78_RS23080	COG1263	PTS System
HFZ78_RS23080	COG2190	(PTS) system
HFZ78_RS23080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_RS23095	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_RS23100	COG0281	malic enzyme
HFZ78_RS23120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFZ78_RS23125	COG3383	formate dehydrogenase (NAD+) activity
HFZ78_RS23130	COG5609	conserved protein (DUF2294)
HFZ78_RS23140	COG1619	proteins homologs of microcin C7 resistance protein MccF
HFZ78_RS23145	COG1525	nuclease
HFZ78_RS23160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFZ78_RS23165	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HFZ78_RS23175	COG0393	Putative heavy-metal-binding
HFZ78_RS23180	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS23185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ78_RS23195	COG3973	AAA domain
HFZ78_RS23210	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_RS23225	COG5002	protein histidine kinase activity
HFZ78_RS23230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HFZ78_RS23235	COG0784	Response regulator, receiver
HFZ78_RS23235	COG2205	protein histidine kinase activity
HFZ78_RS23240	COG0028	Belongs to the TPP enzyme family
HFZ78_RS23245	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ78_RS23260	COG0765	amino acid transport
HFZ78_RS23270	COG1473	amidohydrolase
HFZ78_RS23305	COG0765	amino acid transport
HFZ78_RS23310	COG0765	amino acid transport
HFZ78_RS23315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS23320	COG1126	abc transporter atp-binding protein
HFZ78_RS23325	COG1113	amino acid transport
HFZ78_RS23330	COG3773	Cell wall hydrolase
HFZ78_RS23335	COG2321	neutral zinc metallopeptidase
HFZ78_RS23340	COG1609	Transcriptional regulator
HFZ78_RS23345	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS23355	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS23360	COG4946	Tricorn protease homolog
HFZ78_RS23360	COG1506	peptidase
HFZ78_RS23360	COG0823	Involved in the tonB-independent uptake of proteins
HFZ78_RS23400	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS23405	COG0653	protein targeting
HFZ78_RS23430	COG1733	regulation of RNA biosynthetic process
HFZ78_RS23445	COG1979	alcohol dehydrogenase
HFZ78_RS23450	COG0500	methyltransferase
HFZ78_RS23465	COG2738	Putative neutral zinc metallopeptidase
HFZ78_RS23470	COG0561	phosphatase activity
HFZ78_RS23475	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ78_RS23480	COG0667	Aldo Keto reductase
HFZ78_RS23490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HFZ78_RS23500	COG0697	spore germination
HFZ78_RS23505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS23530	COG2222	sugar isomerase
HFZ78_RS23535	COG0697	spore germination
HFZ78_RS23540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_RS23545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_RS23550	COG2188	Transcriptional regulator
HFZ78_RS23555	COG0129	dihydroxy-acid dehydratase activity
HFZ78_RS23565	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS23570	COG1486	melibiose metabolic process
HFZ78_RS23595	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS23600	COG1175	transmembrane transport
HFZ78_RS23610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_RS23615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS23620	COG2271	Major facilitator Superfamily
HFZ78_RS23640	COG3338	carbonate dehydratase activity
HFZ78_RS23655	COG1288	antiporter activity
HFZ78_RS23660	COG1473	amidohydrolase
HFZ78_RS23665	COG0583	DNA-binding transcription factor activity
HFZ78_RS23705	COG0667	Aldo Keto reductase
HFZ78_RS23740	COG4221	oxidoreductase activity
HFZ78_RS23755	COG2801	Transposase and inactivated derivatives
HFZ78_RS23795	COG0281	malic enzyme
HFZ78_RS23805	COG1024	Enoyl-CoA hydratase
HFZ78_RS23825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS23840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFZ78_RS23845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFZ78_RS23875	COG2003	Belongs to the UPF0758 family
HFZ78_RS23885	COG4873	Protein conserved in bacteria
HFZ78_RS24050	COG0583	DNA-binding transcription factor activity
HFZ78_RS24080	COG0583	DNA-binding transcription factor activity
HFZ78_RS24125	COG0242	peptide deformylase activity
HFZ78_RS24185	COG0477	Major facilitator Superfamily
HFZ78_RS24200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_RS24235	COG0194	GDP metabolic process
HFZ78_RS24240	COG0450	alkyl hydroperoxide reductase
HFZ78_RS24255	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS24270	COG0561	phosphatase activity
HFZ78_RS24280	COG1278	Cold shock
HFZ78_RS24285	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_RS24295	COG1011	Hydrolase
HFZ78_RS24310	COG0346	lactoylglutathione lyase activity
HFZ78_RS24360	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS24365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_RS24380	COG5337	Spore coat protein CotH
HFZ78_RS24390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFZ78_RS24420	COG2027	D-alanyl-D-alanine carboxypeptidase
HFZ78_RS24430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFZ78_RS24450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ78_RS24450	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ78_RS24455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HFZ78_RS24460	COG0517	IMP dehydrogenase activity
HFZ78_RS24530	COG2226	methyltransferase
HFZ78_RS24535	COG0708	Exodeoxyribonuclease III
HFZ78_RS24540	COG2861	carbohydrate metabolic process
HFZ78_RS24545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFZ78_RS24560	COG1657	PFAM Prenyltransferase squalene oxidase
HFZ78_RS24565	COG3663	DNA glycosylase
HFZ78_RS24570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS24575	COG1757	Na H antiporter
HFZ78_RS24585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_RS24590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_RS24595	COG3850	Histidine kinase
HFZ78_RS24595	COG5002	protein histidine kinase activity
HFZ78_RS24600	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS24610	COG1024	Enoyl-CoA hydratase
HFZ78_RS24615	COG2045	Belongs to the ComB family
HFZ78_RS24625	COG1309	transcriptional regulator
HFZ78_RS24630	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS24635	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS24640	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS24650	COG2720	vancomycin resistance protein
HFZ78_RS24660	COG2226	methyltransferase
HFZ78_RS24670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS24690	COG2323	membrane
HFZ78_RS24695	COG0697	spore germination
HFZ78_RS24705	COG0778	Nitroreductase
HFZ78_RS24710	COG1733	regulation of RNA biosynthetic process
HFZ78_RS24715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS24720	COG0833	amino acid
HFZ78_RS24735	COG0017	Asparaginyl-tRNA synthetase
HFZ78_RS24760	COG3973	AAA domain
HFZ78_RS24775	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_RS24800	COG0561	phosphatase activity
HFZ78_RS24815	COG0789	Transcriptional regulator
HFZ78_RS24820	COG3594	Acyltransferase
HFZ78_RS24825	COG2404	hydrolase activity, acting on ester bonds
HFZ78_RS24835	COG0778	Nitroreductase
HFZ78_RS24845	COG1136	(ABC) transporter
HFZ78_RS24850	COG0577	efflux transmembrane transporter activity
HFZ78_RS24855	COG5002	protein histidine kinase activity
HFZ78_RS24855	COG3850	Histidine kinase
HFZ78_RS24890	COG0527	aspartate kinase activity
HFZ78_RS24910	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_RS24915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_RS24920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HFZ78_RS24925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFZ78_RS24930	COG4120	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS24940	COG0475	glutathione-regulated potassium exporter activity
HFZ78_RS24955	COG1418	mRNA catabolic process
HFZ78_RS24960	COG1525	nuclease
HFZ78_RS24965	COG1368	sulfuric ester hydrolase activity
HFZ78_RS24985	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS24990	COG0569	domain protein
HFZ78_RS24995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_RS25000	COG2223	nitrite transmembrane transporter activity
HFZ78_RS25005	COG2223	nitrite transmembrane transporter activity
HFZ78_RS25010	COG3383	formate dehydrogenase (NAD+) activity
HFZ78_RS25015	COG0243	molybdopterin cofactor binding
HFZ78_RS25020	COG5002	protein histidine kinase activity
HFZ78_RS25050	COG1346	cytolysis
HFZ78_RS25055	COG1380	Effector of murein hydrolase LrgA
HFZ78_RS25060	COG1999	signal sequence binding
HFZ78_RS25065	COG0488	(ABC) transporter
HFZ78_RS25080	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFZ78_RS25085	COG4149	molybdate abc transporter
HFZ78_RS25090	COG1686	Belongs to the peptidase S11 family
HFZ78_RS25095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFZ78_RS25095	COG0392	lysyltransferase activity
HFZ78_RS25110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFZ78_RS25130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFZ78_RS25155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HFZ78_RS25185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFZ78_RS25185	COG0512	Glutamine amidotransferase of anthranilate synthase
HFZ78_RS25190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFZ78_RS25195	COG2814	Major facilitator Superfamily
HFZ78_RS25200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS25200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS25200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_RS25205	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_RS25210	COG1349	DNA-binding transcription factor activity
HFZ78_RS25245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HFZ78_RS25250	COG3285	dna ligase
HFZ78_RS25250	COG1793	dna ligase
HFZ78_RS25255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HFZ78_RS25285	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_RS25315	COG0523	cobalamin synthesis protein
HFZ78_RS25320	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_RS25320	COG0793	Belongs to the peptidase S41A family
HFZ78_RS25330	COG2217	Heavy metal translocating P-type atpase
HFZ78_RS25345	COG4326	sporulation control protein
HFZ78_RS25350	COG0515	serine threonine protein kinase
HFZ78_RS25370	COG4479	Belongs to the UPF0346 family
HFZ78_RS25380	COG1509	lysine 2,3-aminomutase activity
HFZ78_RS25385	COG3829	transcription factor binding
HFZ78_RS25390	COG0456	acetyltransferase
HFZ78_RS25395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_RS25400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS25405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS25410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_RS25415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_RS25420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HFZ78_RS25435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ78_RS25440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ78_RS25460	COG2755	lipolytic protein G-D-S-L family
HFZ78_RS25465	COG1999	signal sequence binding
HFZ78_RS25485	COG1307	EDD domain protein, DegV family
HFZ78_RS25495	COG0805	protein transport
HFZ78_RS25500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_RS25510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFZ78_RS25525	COG2310	stress, protein
HFZ78_RS25530	COG2310	stress, protein
HFZ78_RS25535	COG3853	Toxic anion resistance protein (TelA)
HFZ78_RS25570	COG0861	Integral membrane protein TerC family
HFZ78_RS25575	COG2310	stress, protein
HFZ78_RS25590	COG1413	lyase activity
HFZ78_RS25595	COG0488	(ABC) transporter
HFZ78_RS25600	COG1418	mRNA catabolic process
HFZ78_RS25605	COG1307	EDD domain protein, DegV family
HFZ78_RS25620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HFZ78_RS25630	COG1321	iron dependent repressor
HFZ78_RS25635	COG0551	DNA topoisomerase type I activity
HFZ78_RS25635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_RS25645	COG1278	Cold shock
HFZ78_RS25655	COG0328	RNA-DNA hybrid ribonuclease activity
HFZ78_RS25660	COG0328	RNA-DNA hybrid ribonuclease activity
HFZ78_RS25675	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HFZ78_RS25700	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS25715	COG1357	PFAM Pentapeptide repeats (8 copies)
HFZ78_RS25715	COG0515	serine threonine protein kinase
HFZ78_RS25720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_RS25730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HFZ78_RS25735	COG1755	Isoprenylcysteine carboxyl methyltransferase
HFZ78_RS25740	COG3424	synthase
HFZ78_RS25750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFZ78_RS25755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_RS25760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFZ78_RS25795	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ78_RS25800	COG1199	ATP-dependent helicase activity
HFZ78_RS25805	COG0116	Belongs to the methyltransferase superfamily
HFZ78_RS25820	COG4474	Belongs to the UPF0398 family
HFZ78_RS25830	COG3359	exonuclease
HFZ78_RS25835	COG1111	helicase
HFZ78_RS25835	COG1205	dead DEAH box helicase
HFZ78_RS25840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS25845	COG1151	hydroxylamine reductase activity
HFZ78_RS25880	COG3331	DNA recombination
HFZ78_RS25885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_RS25885	COG4499	WXG100 protein secretion system (Wss), protein YukC
HFZ78_RS25895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFZ78_RS25900	COG3935	DnaD domain protein
HFZ78_RS25925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFZ78_RS25925	COG1199	ATP-dependent helicase activity
HFZ78_RS25930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HFZ78_RS25935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HFZ78_RS25950	COG0617	tRNA 3'-terminal CCA addition
HFZ78_RS25955	COG0438	transferase activity, transferring glycosyl groups
HFZ78_RS25960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_RS25965	COG1803	Methylglyoxal synthase
HFZ78_RS25970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HFZ78_RS25975	COG1694	Mazg nucleotide pyrophosphohydrolase
HFZ78_RS25980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS25990	COG4347	Protein of unknown function (DUF1405)
HFZ78_RS26000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HFZ78_RS26015	COG5582	Belongs to the UPF0302 family
HFZ78_RS26020	COG0457	Tetratricopeptide repeat
HFZ78_RS26030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFZ78_RS26035	COG0287	Prephenate dehydrogenase
HFZ78_RS26040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ78_RS26050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HFZ78_RS26060	COG0105	UTP biosynthetic process
HFZ78_RS26065	COG0142	geranyltranstransferase activity
HFZ78_RS26070	COG2226	methyltransferase
HFZ78_RS26085	COG0302	gtp cyclohydrolase
HFZ78_RS26090	COG0776	regulation of translation
HFZ78_RS26095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HFZ78_RS26115	COG1160	GTP binding
HFZ78_RS26130	COG1304	FMN binding
HFZ78_RS26135	COG0539	negative regulation of cytoplasmic translation
HFZ78_RS26145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HFZ78_RS26155	COG2959	enzyme of heme biosynthesis
HFZ78_RS26160	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_RS26160	COG3773	Cell wall hydrolase
HFZ78_RS26165	COG2339	peptidase activity
HFZ78_RS26175	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_RS26180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS26185	COG4862	establishment of competence for transformation
HFZ78_RS26190	COG1408	metallophosphoesterase
HFZ78_RS26210	COG3546	catalase activity
HFZ78_RS26220	COG1388	LysM domain
HFZ78_RS26220	COG4641	Protein conserved in bacteria
HFZ78_RS26225	COG1266	CAAX protease self-immunity
HFZ78_RS26230	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_RS26245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HFZ78_RS26255	COG1388	LysM domain
HFZ78_RS26255	COG0791	NLP P60 protein
HFZ78_RS26265	COG1595	DNA-templated transcription, initiation
HFZ78_RS26270	COG5002	protein histidine kinase activity
HFZ78_RS26275	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS26280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_RS26285	COG1333	cytochrome c biogenesis protein
HFZ78_RS26290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS26295	COG1187	pseudouridine synthase activity
HFZ78_RS26300	COG0700	Nucleoside recognition
HFZ78_RS26305	COG2715	membrane protein required for spore maturation
HFZ78_RS26310	COG1686	Belongs to the peptidase S11 family
HFZ78_RS26315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFZ78_RS26330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFZ78_RS26345	COG1547	Domain of unknown function (DUF309)
HFZ78_RS26355	COG4086	secreted protein
HFZ78_RS26365	COG0697	spore germination
HFZ78_RS26390	COG2172	sigma factor antagonist activity
HFZ78_RS26395	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_RS26400	COG1686	Belongs to the peptidase S11 family
HFZ78_RS26420	COG4974	Belongs to the 'phage' integrase family
HFZ78_RS26430	COG0735	belongs to the Fur family
HFZ78_RS26435	COG1300	Membrane
HFZ78_RS26440	COG1379	DNA repair
HFZ78_RS26455	COG0667	Aldo Keto reductase
HFZ78_RS26465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_RS26470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_RS26480	COG1073	alpha beta
HFZ78_RS26485	COG4918	Iron-sulphur cluster biosynthesis
HFZ78_RS26495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ78_RS26505	COG3852	Histidine kinase
HFZ78_RS26510	COG0300	oxidoreductase activity
HFZ78_RS26515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS26520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_RS26525	COG1216	Glycosyl transferase, family 2
HFZ78_RS26530	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_RS26535	COG1234	tRNA 3'-trailer cleavage
HFZ78_RS26540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFZ78_RS26545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ78_RS26550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFZ78_RS26555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_RS26560	COG0346	lactoylglutathione lyase activity
HFZ78_RS26570	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_RS26580	COG1126	abc transporter atp-binding protein
HFZ78_RS26585	COG0765	amino acid transport
HFZ78_RS26590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS26605	COG1703	isobutyryl-CoA mutase activity
HFZ78_RS26610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS26610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS26615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_RS26620	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_RS26625	COG0022	dehydrogenase e1 component
HFZ78_RS26630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFZ78_RS26635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ78_RS26650	COG0280	phosphate acetyltransferase
HFZ78_RS26655	COG3829	transcription factor binding
HFZ78_RS26655	COG3290	protein histidine kinase activity
HFZ78_RS26665	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_RS26670	COG3093	addiction module antidote protein HigA
HFZ78_RS26675	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS26680	COG0750	zinc metalloprotease
HFZ78_RS26685	COG0497	DNA recombination
HFZ78_RS26690	COG1438	arginine binding
HFZ78_RS26695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HFZ78_RS26700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFZ78_RS26720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFZ78_RS26725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ78_RS26730	COG1302	Protein conserved in bacteria
HFZ78_RS26735	COG0439	Biotin carboxylase
HFZ78_RS26740	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_RS26780	COG3854	ATPases associated with a variety of cellular activities
HFZ78_RS26790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS26800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_RS26810	COG4555	ABC transporter
HFZ78_RS26830	COG1138	Cytochrome C-type biogenesis protein
HFZ78_RS26835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HFZ78_RS26860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFZ78_RS26865	COG0006	proline dipeptidase activity
HFZ78_RS26875	COG3872	metal-dependent enzyme
HFZ78_RS26885	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_RS26890	COG0791	NLP P60 protein
HFZ78_RS26890	COG1388	LysM domain
HFZ78_RS26895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_RS26900	COG0095	Lipoate-protein ligase
HFZ78_RS26905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFZ78_RS26915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_RS26920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFZ78_RS26925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_RS26935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFZ78_RS26940	COG1459	type II secretion system
HFZ78_RS26945	COG4537	Required for transformation and DNA binding
HFZ78_RS26950	COG4970	Tfp pilus assembly protein FimT
HFZ78_RS26990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS27000	COG0011	TIGRFAM Protein of
HFZ78_RS27010	COG1940	carbohydrate kinase activity
HFZ78_RS27020	COG0705	Rhomboid family
HFZ78_RS27020	COG0457	Tetratricopeptide repeat
HFZ78_RS27040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFZ78_RS27045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_RS27065	COG0704	Plays a role in the regulation of phosphate uptake
HFZ78_RS27070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_RS27075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_RS27080	COG0581	inorganic phosphate transmembrane transporter activity
HFZ78_RS27085	COG0573	inorganic phosphate transmembrane transporter activity
HFZ78_RS27090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFZ78_RS27100	COG0477	Major facilitator Superfamily
HFZ78_RS27110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_RS27120	COG2839	Protein conserved in bacteria
HFZ78_RS27125	COG5521	maltodextrose utilization protein MalA
HFZ78_RS27135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HFZ78_RS27140	COG4709	membrane
HFZ78_RS27145	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HFZ78_RS27155	COG0735	belongs to the Fur family
HFZ78_RS27160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ78_RS27165	COG1121	(ABC) transporter
HFZ78_RS27175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HFZ78_RS27190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HFZ78_RS27195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFZ78_RS27200	COG2384	SAM-dependent methyltransferase
HFZ78_RS27205	COG2010	Cytochrome c
HFZ78_RS27210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFZ78_RS27215	COG0358	DNA primase activity
HFZ78_RS27225	COG0517	IMP dehydrogenase activity
HFZ78_RS27230	COG0423	glycine-tRNA ligase activity
HFZ78_RS27235	COG1381	Involved in DNA repair and RecF pathway recombination
HFZ78_RS27245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFZ78_RS27250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HFZ78_RS27260	COG1480	7TM receptor with intracellular HD hydrolase
HFZ78_RS27265	COG1702	phosphate starvation-inducible protein PhoH
HFZ78_RS27285	COG4864	UPF0365 protein
HFZ78_RS27290	COG1030	water channel activity
HFZ78_RS27295	COG1610	YqeY-like protein
HFZ78_RS27305	COG1283	sodium-dependent phosphate transmembrane transporter activity
HFZ78_RS27310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFZ78_RS27315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ78_RS27320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFZ78_RS27335	COG0443	Heat shock 70 kDa protein
HFZ78_RS27340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFZ78_RS27345	COG1420	regulation of RNA biosynthetic process
HFZ78_RS27350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFZ78_RS27355	COG0481	GTPase activity
HFZ78_RS27365	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_RS27375	COG0268	Binds directly to 16S ribosomal RNA
HFZ78_RS27380	COG1466	dna polymerase III delta subunit
HFZ78_RS27390	COG0658	competence protein
HFZ78_RS27390	COG2333	competence protein COMEC
HFZ78_RS27395	COG2131	deaminase
HFZ78_RS27400	COG1555	photosystem II stabilization
HFZ78_RS27400	COG1596	polysaccharide export
HFZ78_RS27405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_RS27410	COG2226	methyltransferase
HFZ78_RS27415	COG0799	negative regulation of ribosome biogenesis
HFZ78_RS27420	COG1713	HD superfamily hydrolase involved in NAD metabolism
HFZ78_RS27425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFZ78_RS27430	COG1534	Rna-binding protein
HFZ78_RS27440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HFZ78_RS27445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HFZ78_RS27455	COG0688	phosphatidylethanolamine metabolic process
HFZ78_RS27460	COG1183	phosphatidylcholine synthase activity
HFZ78_RS27475	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS27500	COG0626	cystathionine gamma-synthase activity
HFZ78_RS27505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_RS27510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFZ78_RS27520	COG0768	penicillin binding
HFZ78_RS27525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFZ78_RS27530	COG0572	uridine kinase
HFZ78_RS27545	COG4122	O-methyltransferase activity
HFZ78_RS27550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFZ78_RS27555	COG3906	Belongs to the UPF0473 family
HFZ78_RS27560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFZ78_RS27565	COG4472	Bacterial protein of unknown function (DUF965)
HFZ78_RS27570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_RS27575	COG0628	permease
HFZ78_RS27595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFZ78_RS27610	COG1104	cysteine desulfurase activity
HFZ78_RS27615	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_RS27620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFZ78_RS27625	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_RS27630	COG1131	(ABC) transporter
HFZ78_RS27640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFZ78_RS27650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HFZ78_RS27655	COG0124	histidyl-tRNA synthetase
HFZ78_RS27665	COG4991	sh3 domain protein
HFZ78_RS27665	COG3103	Sh3 type 3 domain protein
HFZ78_RS27665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_RS27670	COG2070	2-Nitropropane dioxygenase
HFZ78_RS27685	COG1024	Enoyl-CoA hydratase
HFZ78_RS27690	COG0183	Belongs to the thiolase family
HFZ78_RS27695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_RS27700	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS27705	COG1024	Enoyl-CoA hydratase
HFZ78_RS27735	COG3396	Phenylacetate-CoA oxygenase
HFZ78_RS27740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFZ78_RS27745	COG3162	membrane
HFZ78_RS27750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS27760	COG1490	D-aminoacyl-tRNA deacylase activity
HFZ78_RS27765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFZ78_RS27770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_RS27775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HFZ78_RS27775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFZ78_RS27780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ78_RS27780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ78_RS27790	COG2244	polysaccharide biosynthetic process
HFZ78_RS27795	COG2323	membrane
HFZ78_RS27805	COG1862	Preprotein translocase
HFZ78_RS27815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFZ78_RS27825	COG0632	four-way junction helicase activity
HFZ78_RS27850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFZ78_RS27855	COG0157	Belongs to the NadC ModD family
HFZ78_RS27860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFZ78_RS27865	COG1104	cysteine desulfurase activity
HFZ78_RS27870	COG1827	regulation of RNA biosynthetic process
HFZ78_RS27875	COG0077	Prephenate dehydratase
HFZ78_RS27880	COG4492	Belongs to the UPF0735 family
HFZ78_RS27885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFZ78_RS27890	COG3290	protein histidine kinase activity
HFZ78_RS27895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HFZ78_RS27900	COG2868	ribosomal protein
HFZ78_RS27905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HFZ78_RS27910	COG1530	ribonuclease E activity
HFZ78_RS27915	COG1994	Peptidase M50
HFZ78_RS27920	COG0739	heme binding
HFZ78_RS27925	COG2894	cell division
HFZ78_RS27930	COG0850	regulation of cytokinetic process
HFZ78_RS27940	COG1792	Involved in formation and maintenance of cell shape
HFZ78_RS27945	COG1077	Cell shape determining protein MreB Mrl
HFZ78_RS27950	COG2003	Belongs to the UPF0758 family
HFZ78_RS27985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HFZ78_RS27990	COG0285	dihydrofolate synthase activity
HFZ78_RS27995	COG0525	valine-tRNA ligase activity
HFZ78_RS28010	COG1388	LysM domain
HFZ78_RS28010	COG1388	LysM domain
HFZ78_RS28015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFZ78_RS28020	COG0113	porphobilinogen synthase activity
HFZ78_RS28030	COG0181	hydroxymethylbilane synthase activity
HFZ78_RS28035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_RS28055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFZ78_RS28060	COG0470	DNA polymerase III
HFZ78_RS28060	COG1067	ATP-dependent peptidase activity
HFZ78_RS28070	COG0544	peptidyl-prolyl cis-trans isomerase activity
HFZ78_RS28075	COG1477	protein flavinylation
HFZ78_RS28075	COG0457	Tetratricopeptide repeat
HFZ78_RS28085	COG0622	Phosphoesterase
HFZ78_RS28090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFZ78_RS28095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HFZ78_RS28100	COG5401	PFAM Sporulation and spore germination
HFZ78_RS28110	COG1846	Transcriptional regulator
HFZ78_RS28115	COG4841	protein insertion into membrane
HFZ78_RS28120	COG3852	Histidine kinase
HFZ78_RS28125	COG4191	Histidine kinase
HFZ78_RS28135	COG2197	response regulator
HFZ78_RS28145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFZ78_RS28150	COG1053	succinate dehydrogenase
HFZ78_RS28155	COG2009	succinate dehydrogenase
HFZ78_RS28160	COG1719	4-vinyl reductase, 4VR
HFZ78_RS28170	COG0322	excinuclease ABC activity
HFZ78_RS28175	COG3118	belongs to the thioredoxin family
HFZ78_RS28180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_RS28185	COG2086	electron transfer activity
HFZ78_RS28190	COG1024	Enoyl-CoA hydratase
HFZ78_RS28195	COG1309	transcriptional regulator
HFZ78_RS28200	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS28205	COG3766	membrane
HFZ78_RS28215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFZ78_RS28215	COG1796	DNA polymerase
HFZ78_RS28220	COG1286	toxin biosynthetic process
HFZ78_RS28225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HFZ78_RS28235	COG2154	pterin-4-alpha-carbinolamine dehydratase
HFZ78_RS28240	COG0072	phenylalanine-tRNA ligase activity
HFZ78_RS28240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFZ78_RS28245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFZ78_RS28250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFZ78_RS28260	COG1363	Peptidase, m42
HFZ78_RS28270	COG0697	spore germination
HFZ78_RS28280	COG0756	dUTP diphosphatase activity
HFZ78_RS28290	COG3326	Membrane
HFZ78_RS28295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFZ78_RS28300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HFZ78_RS28305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HFZ78_RS28310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFZ78_RS28320	COG1484	DNA-dependent DNA replication
HFZ78_RS28325	COG3611	Membrane attachment protein
HFZ78_RS28330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFZ78_RS28340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HFZ78_RS28345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFZ78_RS28350	COG0237	dephospho-CoA kinase activity
HFZ78_RS28355	COG1971	Probably functions as a manganese efflux pump
HFZ78_RS28360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFZ78_RS28365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_RS28365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_RS28370	COG5002	protein histidine kinase activity
HFZ78_RS28375	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS28390	COG0039	L-malate dehydrogenase activity
HFZ78_RS28395	COG0538	isocitrate dehydrogenase activity
HFZ78_RS28400	COG0372	Belongs to the citrate synthase family
HFZ78_RS28405	COG2707	UPF0756 membrane protein
HFZ78_RS28410	COG0628	permease
HFZ78_RS28415	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFZ78_RS28430	COG0825	malonyl-CoA metabolic process
HFZ78_RS28440	COG2186	Transcriptional regulator
HFZ78_RS28445	COG0281	malic enzyme
HFZ78_RS28450	COG0587	DNA-directed DNA polymerase activity
HFZ78_RS28465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HFZ78_RS28475	COG4109	DRTGG domain
HFZ78_RS28485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_RS28490	COG0006	proline dipeptidase activity
HFZ78_RS28515	COG0589	response to stress
HFZ78_RS28525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFZ78_RS28535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFZ78_RS28540	COG0827	DNA restriction-modification system
HFZ78_RS28545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HFZ78_RS28550	COG3874	Sporulation protein YtfJ
HFZ78_RS28560	COG1714	RDD family
HFZ78_RS28565	COG0616	signal peptide processing
HFZ78_RS28570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFZ78_RS28575	COG2962	Rard protein
HFZ78_RS28580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_RS28590	COG0301	tRNA thio-modification
HFZ78_RS28595	COG1104	cysteine desulfurase activity
HFZ78_RS28600	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HFZ78_RS28605	COG1309	transcriptional regulator
HFZ78_RS28610	COG1956	GAF domain-containing protein
HFZ78_RS28615	COG0626	cystathionine gamma-synthase activity
HFZ78_RS28620	COG2203	Gaf domain
HFZ78_RS28620	COG2199	diguanylate cyclase activity
HFZ78_RS28625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HFZ78_RS28655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_RS28660	COG0454	-acetyltransferase
HFZ78_RS28665	COG0517	IMP dehydrogenase activity
HFZ78_RS28670	COG0123	including yeast histone deacetylase and acetoin utilization protein
HFZ78_RS28680	COG1605	Chorismate mutase
HFZ78_RS28680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HFZ78_RS28685	COG3118	belongs to the thioredoxin family
HFZ78_RS28700	COG2309	aminopeptidase activity
HFZ78_RS28705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFZ78_RS28710	COG1674	ftsk spoiiie
HFZ78_RS28715	COG4848	Belongs to the UPF0354 family
HFZ78_RS28720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS28725	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HFZ78_RS28730	COG1363	Peptidase, m42
HFZ78_RS28735	COG5584	Small secreted protein
HFZ78_RS28740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_RS28745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFZ78_RS28755	COG0510	thiamine kinase activity
HFZ78_RS28760	COG1523	belongs to the glycosyl hydrolase 13 family
HFZ78_RS28765	COG1597	lipid kinase activity
HFZ78_RS28775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_RS28785	COG1349	DNA-binding transcription factor activity
HFZ78_RS28790	COG1113	amino acid transport
HFZ78_RS28795	COG0583	DNA-binding transcription factor activity
HFZ78_RS28805	COG0640	Transcriptional regulator
HFZ78_RS28815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ78_RS28820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HFZ78_RS28825	COG0783	Belongs to the Dps family
HFZ78_RS28830	COG0726	polysaccharide deacetylase
HFZ78_RS28835	COG1187	pseudouridine synthase activity
HFZ78_RS28840	COG2244	polysaccharide biosynthetic process
HFZ78_RS28845	COG2081	HI0933 family
HFZ78_RS28870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFZ78_RS28875	COG0495	leucyl-tRNA aminoacylation
HFZ78_RS28880	COG2814	Major facilitator Superfamily
HFZ78_RS28885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HFZ78_RS28905	COG1242	4 iron, 4 sulfur cluster binding
HFZ78_RS28910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HFZ78_RS28920	COG2267	carboxylic ester hydrolase activity
HFZ78_RS28925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFZ78_RS28930	COG0367	asparagine synthase
HFZ78_RS28935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HFZ78_RS28950	COG1506	peptidase
HFZ78_RS28955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_RS28960	COG1116	anion transmembrane transporter activity
HFZ78_RS28965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_RS28970	COG0494	nUDIX hydrolase
HFZ78_RS28990	COG1854	S-ribosylhomocysteine lyase activity
HFZ78_RS28995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HFZ78_RS29000	COG0288	reversible hydration of carbon dioxide
HFZ78_RS29010	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ78_RS29015	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS29020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFZ78_RS29025	COG0596	Alpha beta hydrolase
HFZ78_RS29030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HFZ78_RS29035	COG1169	isochorismate synthase
HFZ78_RS29040	COG1575	Belongs to the MenA family. Type 1 subfamily
HFZ78_RS29045	COG0058	SHG alpha-glucan phosphorylase activity
HFZ78_RS29050	COG0297	glycogen (starch) synthase activity
HFZ78_RS29055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFZ78_RS29190	COG1285	pathogenesis
HFZ78_RS29200	COG3162	membrane
HFZ78_RS29205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_RS29220	COG0583	DNA-binding transcription factor activity
HFZ78_RS29225	COG1063	alcohol dehydrogenase
HFZ78_RS29230	COG5577	PFAM Coat F domain
HFZ78_RS29245	COG5577	PFAM Coat F domain
HFZ78_RS29250	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_RS29260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_RS29275	COG0559	Belongs to the binding-protein-dependent transport system permease family
HFZ78_RS29305	COG0083	homoserine kinase activity
HFZ78_RS29310	COG0460	homoserine dehydrogenase
HFZ78_RS29315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ78_RS29325	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS29330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFZ78_RS29340	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_RS29345	COG3290	protein histidine kinase activity
HFZ78_RS29345	COG3829	transcription factor binding
HFZ78_RS29360	COG0531	amino acid
HFZ78_RS29370	COG0783	Belongs to the Dps family
HFZ78_RS29390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HFZ78_RS29395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFZ78_RS29410	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS29415	COG1175	transmembrane transport
HFZ78_RS29420	COG1653	transport
HFZ78_RS29425	COG5578	integral membrane protein
HFZ78_RS29435	COG1132	(ABC) transporter
HFZ78_RS29440	COG1132	(ABC) transporter
HFZ78_RS29460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFZ78_RS29475	COG3250	beta-galactosidase activity
HFZ78_RS29480	COG3250	beta-galactosidase activity
HFZ78_RS29485	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS29490	COG0673	inositol 2-dehydrogenase activity
HFZ78_RS29495	COG1349	DNA-binding transcription factor activity
HFZ78_RS29520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_RS29525	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS29530	COG1175	transmembrane transport
HFZ78_RS29535	COG1653	transport
HFZ78_RS29570	COG1940	carbohydrate kinase activity
HFZ78_RS29575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HFZ78_RS29580	COG3395	kinase activity
HFZ78_RS29585	COG0235	Class ii aldolase
HFZ78_RS29590	COG0383	alpha-mannosidase activity
HFZ78_RS29620	COG0395	ABC-type sugar transport system, permease component
HFZ78_RS29630	COG1609	Transcriptional regulator
HFZ78_RS29635	COG5578	integral membrane protein
HFZ78_RS29645	COG0383	alpha-mannosidase activity
HFZ78_RS29660	COG1069	ribulokinase activity
HFZ78_RS29680	COG1175	transmembrane transport
HFZ78_RS29685	COG1653	transport
HFZ78_RS29690	COG4753	response regulator
HFZ78_RS29690	COG2207	Transcriptional regulator
HFZ78_RS29695	COG2972	Histidine kinase
HFZ78_RS29700	COG1501	Belongs to the glycosyl hydrolase 31 family
HFZ78_RS29710	COG1175	transmembrane transport
HFZ78_RS29715	COG2182	Extracellular solute-binding protein
HFZ78_RS29720	COG3275	phosphorelay sensor kinase activity
HFZ78_RS29725	COG2207	Transcriptional regulator
HFZ78_RS29725	COG4753	response regulator
HFZ78_RS29730	COG1482	cell wall glycoprotein biosynthetic process
HFZ78_RS29735	COG2706	6-phosphogluconolactonase activity
HFZ78_RS29740	COG2323	membrane
HFZ78_RS29755	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HFZ78_RS29775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFZ78_RS29790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFZ78_RS29800	COG1215	transferase activity, transferring glycosyl groups
HFZ78_RS29825	COG0489	protein tyrosine kinase activity
HFZ78_RS29830	COG3944	biosynthesis protein
HFZ78_RS29840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS29850	COG0626	cystathionine gamma-synthase activity
HFZ78_RS29855	COG0626	cystathionine gamma-synthase activity
HFZ78_RS29860	COG0646	methionine synthase
HFZ78_RS29860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFZ78_RS29865	COG0646	methionine synthase
HFZ78_RS29865	COG1410	methionine synthase
HFZ78_RS29870	COG1846	Transcriptional regulator
HFZ78_RS29875	COG2814	Major facilitator Superfamily
HFZ78_RS29880	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_RS29885	COG0346	lactoylglutathione lyase activity
HFZ78_RS29890	COG2814	Major facilitator Superfamily
HFZ78_RS29925	COG0598	Magnesium transport protein CorA
HFZ78_RS29930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFZ78_RS29945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFZ78_RS29955	COG1113	amino acid transport
HFZ78_RS29960	COG1280	lysine exporter protein (LysE YggA)
HFZ78_RS29970	COG0463	Glycosyl transferase, family 2
HFZ78_RS29985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFZ78_RS30000	COG1979	alcohol dehydrogenase
HFZ78_RS30005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_RS30010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_RS30015	COG1098	S1 RNA binding domain
HFZ78_RS30035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_RS30045	COG2032	superoxide dismutase activity
HFZ78_RS30055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFZ78_RS30065	COG5018	Exonuclease
HFZ78_RS30070	COG2050	protein possibly involved in aromatic compounds catabolism
HFZ78_RS30080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFZ78_RS30085	COG3584	3D domain protein
HFZ78_RS30105	COG1252	NADH dehydrogenase
HFZ78_RS30120	COG0316	Belongs to the HesB IscA family
HFZ78_RS30130	COG1252	NADH dehydrogenase
HFZ78_RS30140	COG4837	Protein of unknown function (DUF1462)
HFZ78_RS30145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HFZ78_RS30150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFZ78_RS30155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFZ78_RS30160	COG0647	UMP catabolic process
HFZ78_RS30165	COG2445	Protein of unknown function DUF86
HFZ78_RS30180	COG4470	Protein conserved in bacteria
HFZ78_RS30190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFZ78_RS30195	COG0739	heme binding
HFZ78_RS30205	COG3377	Domain of unknown function (DUF1805)
HFZ78_RS30210	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_RS30215	COG0730	response to heat
HFZ78_RS30220	COG1801	Protein of unknown function DUF72
HFZ78_RS30225	COG0719	Fe-S assembly protein
HFZ78_RS30230	COG0822	iron-sulfur transferase activity
HFZ78_RS30235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFZ78_RS30240	COG0719	Fe-S assembly protein
HFZ78_RS30245	COG0396	ATPase activity
HFZ78_RS30250	COG1464	Belongs to the NlpA lipoprotein family
HFZ78_RS30255	COG2011	ABC-type metal ion transport system permease component
HFZ78_RS30260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFZ78_RS30265	COG2873	o-acetylhomoserine
HFZ78_RS30280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_RS30285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HFZ78_RS30295	COG0509	glycine decarboxylation via glycine cleavage system
HFZ78_RS30300	COG1393	Belongs to the ArsC family
HFZ78_RS30305	COG1960	acyl-CoA dehydrogenase activity
HFZ78_RS30310	COG0183	Belongs to the thiolase family
HFZ78_RS30315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_RS30315	COG1024	Enoyl-CoA hydratase
HFZ78_RS30330	COG5577	PFAM Coat F domain
HFZ78_RS30345	COG1120	ATPase activity
HFZ78_RS30350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS30355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_RS30360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_RS30365	COG0772	Belongs to the SEDS family
HFZ78_RS30380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_RS30385	COG1910	domain protein
HFZ78_RS30400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFZ78_RS30410	COG2205	protein histidine kinase activity
HFZ78_RS30415	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS30420	COG5002	protein histidine kinase activity
HFZ78_RS30420	COG3850	Histidine kinase
HFZ78_RS30425	COG2268	Band 7 protein
HFZ78_RS30430	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFZ78_RS30435	COG1126	abc transporter atp-binding protein
HFZ78_RS30440	COG0765	amino acid transport
HFZ78_RS30445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS30455	COG1607	acyl-coa hydrolase
HFZ78_RS30475	COG0628	permease
HFZ78_RS30480	COG0726	polysaccharide deacetylase
HFZ78_RS30505	COG5577	PFAM Coat F domain
HFZ78_RS30520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HFZ78_RS30525	COG0557	exoribonuclease II activity
HFZ78_RS30530	COG1647	Serine aminopeptidase, S33
HFZ78_RS30535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFZ78_RS30540	COG0148	phosphopyruvate hydratase activity
HFZ78_RS30545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFZ78_RS30555	COG0126	phosphoglycerate kinase activity
HFZ78_RS30575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HFZ78_RS30590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_RS30595	COG1481	regulation of sporulation
HFZ78_RS30600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HFZ78_RS30605	COG1660	Displays ATPase and GTPase activities
HFZ78_RS30610	COG1051	belongs to the nudix hydrolase family
HFZ78_RS30615	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_RS30620	COG0457	Tetratricopeptide repeat
HFZ78_RS30625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFZ78_RS30625	COG0140	phosphoribosyl-ATP diphosphatase activity
HFZ78_RS30630	COG0107	imidazoleglycerol-phosphate synthase activity
HFZ78_RS30635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HFZ78_RS30640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFZ78_RS30645	COG0131	Imidazoleglycerol-phosphate dehydratase
HFZ78_RS30650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFZ78_RS30655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFZ78_RS30660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HFZ78_RS30665	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_RS30670	COG0110	maltose O-acetyltransferase activity
HFZ78_RS30675	COG0546	phosphoglycolate phosphatase activity
HFZ78_RS30680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_RS30685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFZ78_RS30690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFZ78_RS30695	COG1950	PFAM Membrane protein of
HFZ78_RS30700	COG3595	metallopeptidase activity
HFZ78_RS30710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFZ78_RS30715	COG0556	nucleotide-excision repair
HFZ78_RS30720	COG4897	Protein conserved in bacteria
HFZ78_RS30725	COG4145	pantothenate transmembrane transporter activity
HFZ78_RS30740	COG1388	LysM domain
HFZ78_RS30760	COG2608	mercury ion transmembrane transporter activity
HFZ78_RS30800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_RS30805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_RS30810	COG0765	amino acid transport
HFZ78_RS30815	COG1126	abc transporter atp-binding protein
HFZ78_RS30820	COG1294	oxidase, subunit
HFZ78_RS30825	COG1271	oxidase subunit
HFZ78_RS30830	COG3336	cytochrome c oxidase
HFZ78_RS30840	COG0463	Glycosyl transferase, family 2
HFZ78_RS30855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFZ78_RS30860	COG0586	Pfam SNARE associated Golgi protein
HFZ78_RS30870	COG3850	Histidine kinase
HFZ78_RS30870	COG5002	protein histidine kinase activity
HFZ78_RS30875	COG0745	RESPONSE REGULATOR receiver
HFZ78_RS30890	COG1131	(ABC) transporter
HFZ78_RS30905	COG5577	PFAM Coat F domain
HFZ78_RS30915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_RS30920	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_RS30920	COG0793	Belongs to the peptidase S41A family
HFZ78_RS30925	COG3883	PFAM NLP P60 protein
HFZ78_RS30925	COG0791	NLP P60 protein
HFZ78_RS30930	COG2177	Part of the ABC transporter FtsEX involved in
HFZ78_RS30935	COG2884	Cell division ATP-binding protein ftsE
HFZ78_RS30945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS30960	COG1405	negative regulation of cell septum assembly
HFZ78_RS30960	COG3012	SEC-C Motif Domain Protein
HFZ78_RS30985	COG3005	denitrification pathway
HFZ78_RS30995	COG0653	protein targeting
HFZ78_RS31005	COG5577	PFAM Coat F domain
HFZ78_RS31010	COG1040	competence protein
HFZ78_RS31015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HFZ78_RS31035	COG1307	EDD domain protein, DegV family
HFZ78_RS31040	COG2197	response regulator
HFZ78_RS31045	COG4585	Histidine kinase
HFZ78_RS31050	COG1739	Uncharacterized protein family UPF0029
HFZ78_RS31055	COG1316	TRANSCRIPTIONal
HFZ78_RS31060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFZ78_RS31075	COG1682	transport, permease protein
HFZ78_RS31080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HFZ78_RS31085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HFZ78_RS31115	COG4193	domain, Protein
HFZ78_RS31165	COG1316	TRANSCRIPTIONal
HFZ78_RS31170	COG3583	domain protein
HFZ78_RS31170	COG3584	3D domain protein
HFZ78_RS31175	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_RS31270	COG1216	Glycosyl transferase, family 2
HFZ78_RS31345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_RS31350	COG0463	Glycosyl transferase, family 2
HFZ78_RS31370	COG1876	peptidase activity
HFZ78_RS31375	COG3853	Toxic anion resistance protein (TelA)
HFZ78_RS31380	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HFZ78_RS31390	COG0346	lactoylglutathione lyase activity
HFZ78_RS31395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HFZ78_RS31400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_RS31415	COG0606	chelatase, subunit chli
HFZ78_RS31435	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HFZ78_RS31445	COG0243	molybdopterin cofactor binding
HFZ78_RS31450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_RS31455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ78_RS31465	COG0577	efflux transmembrane transporter activity
HFZ78_RS31465	COG1136	(ABC) transporter
HFZ78_RS31470	COG1136	(ABC) transporter
HFZ78_RS31485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFZ78_RS31490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ78_RS31505	COG2356	endonuclease I
HFZ78_RS31510	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_RS31515	COG1522	sequence-specific DNA binding
HFZ78_RS31520	COG0436	Aminotransferase
HFZ78_RS31525	COG3706	GGDEF domain
HFZ78_RS31530	COG2252	PERMEase
HFZ78_RS31565	COG2222	sugar isomerase
HFZ78_RS31575	COG2222	sugar isomerase
HFZ78_RS31580	COG2814	Major facilitator Superfamily