locus-tag	class	description
CHR53_RS00010	COG0592	DNA-directed DNA polymerase activity
CHR53_RS00015	COG2501	S4 domain
CHR53_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHR53_RS00030	COG0187	DNA topoisomerase II activity
CHR53_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHR53_RS00075	COG0517	IMP dehydrogenase activity
CHR53_RS00075	COG0516	GMP reductase activity
CHR53_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CHR53_RS00105	COG1428	Deoxynucleoside kinase
CHR53_RS00110	COG1428	Deoxynucleoside kinase
CHR53_RS00115	COG3858	chitin binding
CHR53_RS00115	COG1388	LysM domain
CHR53_RS00120	COG1335	isochorismatase
CHR53_RS00125	COG0590	tRNA wobble adenosine to inosine editing
CHR53_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHR53_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHR53_RS00190	COG1982	Orn Lys Arg decarboxylase major
CHR53_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHR53_RS00200	COG3870	Protein conserved in bacteria
CHR53_RS00205	COG0470	DNA polymerase III
CHR53_RS00210	COG1774	PSP1 C-terminal conserved region
CHR53_RS00215	COG4467	Involved in initiation control of chromosome replication
CHR53_RS00220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CHR53_RS00225	COG2827	Endonuclease containing a URI domain
CHR53_RS00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CHR53_RS00235	COG2002	toxin-antitoxin pair type II binding
CHR53_RS00245	COG0084	hydrolase, TatD family'
CHR53_RS00250	COG3583	domain protein
CHR53_RS00250	COG3584	3D domain protein
CHR53_RS00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHR53_RS00270	COG4466	Protein conserved in bacteria
CHR53_RS00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHR53_RS00290	COG0251	oxidation-reduction process
CHR53_RS00295	COG2088	sporulation resulting in formation of a cellular spore
CHR53_RS00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHR53_RS00310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CHR53_RS00325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHR53_RS00330	COG2002	toxin-antitoxin pair type II binding
CHR53_RS00335	COG2244	polysaccharide biosynthetic process
CHR53_RS00340	COG3956	TIGRFAM MazG family protein
CHR53_RS00345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CHR53_RS00365	COG1098	S1 RNA binding domain
CHR53_RS00370	COG2208	phosphoserine phosphatase activity
CHR53_RS00375	COG2304	oxidoreductase activity
CHR53_RS00380	COG0515	serine threonine protein kinase
CHR53_RS00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CHR53_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHR53_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CHR53_RS00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CHR53_RS00410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHR53_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CHR53_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CHR53_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHR53_RS00430	COG1396	sequence-specific DNA binding
CHR53_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHR53_RS00440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHR53_RS00530	COG3880	PFAM UvrB UvrC protein
CHR53_RS00535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CHR53_RS00540	COG0542	response to heat
CHR53_RS00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CHR53_RS00550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CHR53_RS00555	COG4956	integral membrane protein (PIN domain superfamily)
CHR53_RS00560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CHR53_RS00565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CHR53_RS00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHR53_RS00575	COG1045	serine acetyltransferase
CHR53_RS00580	COG0215	cysteine-tRNA ligase activity
CHR53_RS00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHR53_RS00595	COG3688	RNA-binding protein containing a PIN domain
CHR53_RS00605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHR53_RS00610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CHR53_RS00615	COG0250	Participates in transcription elongation, termination and antitermination
CHR53_RS00620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHR53_RS00625	COG0081	regulation of translation
CHR53_RS00630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHR53_RS00635	COG0222	ribosome binding
CHR53_RS00640	COG2813	Specifically methylates the guanine in position
CHR53_RS00650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CHR53_RS00655	COG1358	cellular component organization or biogenesis
CHR53_RS00660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHR53_RS00665	COG0049	tRNA binding
CHR53_RS00670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHR53_RS00675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHR53_RS00685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHR53_RS00690	COG0088	Forms part of the polypeptide exit tunnel
CHR53_RS00700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHR53_RS00705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHR53_RS00715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHR53_RS00720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHR53_RS00735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHR53_RS00740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHR53_RS00745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHR53_RS00760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHR53_RS00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHR53_RS00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHR53_RS00775	COG1841	ribosomal large subunit assembly
CHR53_RS00785	COG0201	protein transport
CHR53_RS00790	COG0563	adenylate kinase activity
CHR53_RS00795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHR53_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHR53_RS00805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHR53_RS00810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHR53_RS00815	COG0202	RNA polymerase activity
CHR53_RS00820	COG0203	ribosomal protein L17
CHR53_RS00825	COG1122	ATPase activity
CHR53_RS00830	COG1122	ATPase activity
CHR53_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CHR53_RS00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHR53_RS00850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CHR53_RS00895	COG2197	response regulator
CHR53_RS00900	COG4585	Histidine kinase
CHR53_RS00900	COG2203	Gaf domain
CHR53_RS00910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CHR53_RS00915	COG0300	oxidoreductase activity
CHR53_RS00920	COG1609	Transcriptional regulator
CHR53_RS00925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR53_RS00935	COG0697	spore germination
CHR53_RS00965	COG0477	Major facilitator Superfamily
CHR53_RS01000	COG1396	sequence-specific DNA binding
CHR53_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS01035	COG3069	C4-dicarboxylate transmembrane transporter activity
CHR53_RS01045	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHR53_RS01050	COG0489	protein tyrosine kinase activity
CHR53_RS01060	COG2194	sulfuric ester hydrolase activity
CHR53_RS01065	COG0726	polysaccharide deacetylase
CHR53_RS01140	COG1609	Transcriptional regulator
CHR53_RS01145	COG1077	Cell shape determining protein MreB Mrl
CHR53_RS01155	COG1595	DNA-templated transcription, initiation
CHR53_RS01160	COG5662	AntiSigma factor
CHR53_RS01165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CHR53_RS01170	COG4856	YbbR-like protein
CHR53_RS01175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHR53_RS01180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHR53_RS01185	COG3162	membrane
CHR53_RS01190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS01200	COG2259	Doxx family
CHR53_RS01205	COG0346	lactoylglutathione lyase activity
CHR53_RS01225	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CHR53_RS01230	COG2213	PTS system mannitol-specific
CHR53_RS01230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHR53_RS01235	COG3711	transcriptional antiterminator
CHR53_RS01240	COG0246	Mannitol dehydrogenase
CHR53_RS01245	COG2309	aminopeptidase activity
CHR53_RS01260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS01265	COG1131	(ABC) transporter
CHR53_RS01280	COG3829	transcription factor binding
CHR53_RS01285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHR53_RS01290	COG0833	amino acid
CHR53_RS01305	COG3858	chitin binding
CHR53_RS01305	COG1388	LysM domain
CHR53_RS01310	COG3511	phospholipase C
CHR53_RS01315	COG0655	NAD(P)H dehydrogenase (quinone) activity
CHR53_RS01320	COG0583	DNA-binding transcription factor activity
CHR53_RS01355	COG2062	phosphohistidine phosphatase, SixA
CHR53_RS01365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CHR53_RS01380	COG3030	protein affecting phage T7 exclusion by the F plasmid
CHR53_RS01385	COG0693	protein deglycase activity
CHR53_RS01400	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CHR53_RS01430	COG0346	lactoylglutathione lyase activity
CHR53_RS01445	COG2318	DinB family
CHR53_RS01450	COG4555	ABC transporter
CHR53_RS01490	COG0697	spore germination
CHR53_RS01495	COG1309	transcriptional regulator
CHR53_RS01505	COG0018	arginyl-trna synthetase
CHR53_RS01515	COG2814	Major facilitator Superfamily
CHR53_RS01520	COG2076	Multidrug Resistance protein
CHR53_RS01525	COG2076	Multidrug Resistance protein
CHR53_RS01530	COG0586	Pfam SNARE associated Golgi protein
CHR53_RS01535	COG0772	Belongs to the SEDS family
CHR53_RS01540	COG2239	Acts as a magnesium transporter
CHR53_RS01550	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHR53_RS01555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHR53_RS01560	COG0513	Belongs to the DEAD box helicase family
CHR53_RS01575	COG0697	spore germination
CHR53_RS01580	COG3402	PFAM membrane-flanked domain
CHR53_RS01585	COG3428	Bacterial PH domain
CHR53_RS01590	COG0705	Rhomboid family
CHR53_RS01595	COG0736	holo-[acyl-carrier-protein] synthase activity
CHR53_RS01600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CHR53_RS01610	COG0864	Transcriptional regulator
CHR53_RS01615	COG2337	Toxic component of a toxin-antitoxin (TA) module
CHR53_RS01620	COG2183	response to ionizing radiation
CHR53_RS01630	COG3091	SprT-like family
CHR53_RS01705	COG0802	atpase or kinase
CHR53_RS01710	COG1214	PFAM Peptidase M22, glycoprotease
CHR53_RS01715	COG0456	acetyltransferase
CHR53_RS01725	COG0488	(ABC) transporter
CHR53_RS01730	COG0315	cyclic pyranopterin monophosphate synthase activity
CHR53_RS01735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CHR53_RS01745	COG1266	CAAX protease self-immunity
CHR53_RS01750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CHR53_RS01755	COG0459	protein refolding
CHR53_RS01760	COG4974	Belongs to the 'phage' integrase family
CHR53_RS01890	COG0745	RESPONSE REGULATOR receiver
CHR53_RS01895	COG5002	protein histidine kinase activity
CHR53_RS01925	COG0501	Belongs to the peptidase M48B family
CHR53_RS01930	COG1472	Belongs to the glycosyl hydrolase 3 family
CHR53_RS01935	COG1278	Cold shock
CHR53_RS01950	COG1733	regulation of RNA biosynthetic process
CHR53_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS01970	COG1131	(ABC) transporter
CHR53_RS02010	COG2508	Transcriptional regulator
CHR53_RS02025	COG0145	ligase activity
CHR53_RS02120	COG2204	response regulator
CHR53_RS02130	COG0028	Belongs to the TPP enzyme family
CHR53_RS02135	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS02140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHR53_RS02145	COG0833	amino acid
CHR53_RS02155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS02165	COG4294	response to UV
CHR53_RS02190	COG1840	ABC-type Fe3 transport system, periplasmic component
CHR53_RS02195	COG3842	ATPase activity
CHR53_RS02220	COG1349	DNA-binding transcription factor activity
CHR53_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS02235	COG3829	transcription factor binding
CHR53_RS02240	COG0657	acetylesterase activity
CHR53_RS02245	COG4638	Rieske (2fe-2S)
CHR53_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS02255	COG0473	3-isopropylmalate dehydrogenase activity
CHR53_RS02260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CHR53_RS02270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS02275	COG0714	Associated with various cellular activities
CHR53_RS02280	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CHR53_RS02285	COG1305	Transglutaminase-like
CHR53_RS02290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CHR53_RS02290	COG0519	Catalyzes the synthesis of GMP from XMP
CHR53_RS02300	COG2252	PERMEase
CHR53_RS02305	COG1131	(ABC) transporter
CHR53_RS02310	COG1511	domain protein
CHR53_RS02310	COG0842	Transport permease protein
CHR53_RS02315	COG0842	Transport permease protein
CHR53_RS02320	COG3711	transcriptional antiterminator
CHR53_RS02325	COG2190	(PTS) system
CHR53_RS02325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR53_RS02325	COG1263	PTS System
CHR53_RS02360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CHR53_RS02365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CHR53_RS02370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CHR53_RS02375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CHR53_RS02380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHR53_RS02385	COG0047	phosphoribosylformylglycinamidine synthase activity
CHR53_RS02390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHR53_RS02395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CHR53_RS02400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CHR53_RS02405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CHR53_RS02415	COG0151	Belongs to the GarS family
CHR53_RS02425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CHR53_RS02430	COG1470	cell adhesion involved in biofilm formation
CHR53_RS02435	COG4496	protein, YerC YecD
CHR53_RS02440	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CHR53_RS02445	COG0210	DNA helicase
CHR53_RS02455	COG4851	CamS sex pheromone cAM373 precursor
CHR53_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS02485	COG4412	M6 family metalloprotease domain protein
CHR53_RS02485	COG1404	Belongs to the peptidase S8 family
CHR53_RS02495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS02515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CHR53_RS02520	COG2224	Isocitrate lyase
CHR53_RS02525	COG3104	oligopeptide transport
CHR53_RS02530	COG5506	Protein of unknown function (DUF1694)
CHR53_RS02540	COG0741	lytic transglycosylase activity
CHR53_RS02545	COG1764	response to oxidative stress
CHR53_RS02555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHR53_RS02560	COG0154	amidase activity
CHR53_RS02570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS02580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHR53_RS02585	COG2226	methyltransferase
CHR53_RS02590	COG1126	abc transporter atp-binding protein
CHR53_RS02595	COG0765	amino acid transport
CHR53_RS02600	COG0765	amino acid transport
CHR53_RS02610	COG1595	DNA-templated transcription, initiation
CHR53_RS02630	COG1597	lipid kinase activity
CHR53_RS02635	COG1335	isochorismatase
CHR53_RS02640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CHR53_RS02645	COG0733	neurotransmitter:sodium symporter activity
CHR53_RS02660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHR53_RS02700	COG0210	DNA helicase
CHR53_RS02735	COG0668	transmembrane transport
CHR53_RS02740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHR53_RS02750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHR53_RS02770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHR53_RS02780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS02800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS02815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHR53_RS02820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHR53_RS02825	COG1120	ATPase activity
CHR53_RS02835	COG1819	glycosyl
CHR53_RS02845	COG1388	LysM domain
CHR53_RS02845	COG0791	NLP P60 protein
CHR53_RS02845	COG3103	Sh3 type 3 domain protein
CHR53_RS02850	COG3227	Zinc metalloprotease (Elastase)
CHR53_RS02855	COG0436	Aminotransferase
CHR53_RS02860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CHR53_RS02865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CHR53_RS02875	COG0833	amino acid
CHR53_RS02880	COG0824	Thioesterase
CHR53_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS02905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CHR53_RS02930	COG0697	spore germination
CHR53_RS02935	COG2814	Major facilitator Superfamily
CHR53_RS02940	COG0583	DNA-binding transcription factor activity
CHR53_RS02945	COG0730	response to heat
CHR53_RS02970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS02975	COG0765	amino acid transport
CHR53_RS02985	COG1619	proteins homologs of microcin C7 resistance protein MccF
CHR53_RS02995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHR53_RS03005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHR53_RS03010	COG0346	lactoylglutathione lyase activity
CHR53_RS03015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CHR53_RS03025	COG0322	excinuclease ABC activity
CHR53_RS03030	COG0386	Belongs to the glutathione peroxidase family
CHR53_RS03035	COG2936	dipeptidyl-peptidase activity
CHR53_RS03040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS03045	COG0765	amino acid transport
CHR53_RS03050	COG1126	abc transporter atp-binding protein
CHR53_RS03055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CHR53_RS03065	COG0589	response to stress
CHR53_RS03080	COG1126	abc transporter atp-binding protein
CHR53_RS03085	COG0765	amino acid transport
CHR53_RS03090	COG0765	amino acid transport
CHR53_RS03095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS03100	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS03105	COG0109	protoheme IX farnesyltransferase activity
CHR53_RS03110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR53_RS03120	COG2190	(PTS) system
CHR53_RS03125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR53_RS03125	COG1263	PTS System
CHR53_RS03130	COG3711	transcriptional antiterminator
CHR53_RS03145	COG3279	Response regulator of the LytR AlgR family
CHR53_RS03150	COG0427	acetyl-CoA hydrolase
CHR53_RS03155	COG0406	alpha-ribazole phosphatase activity
CHR53_RS03170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHR53_RS03175	COG4605	iron ion homeostasis
CHR53_RS03180	COG4604	ABC transporter, ATP-binding protein
CHR53_RS03185	COG4607	ABC-type enterochelin transport system periplasmic component
CHR53_RS03190	COG5002	protein histidine kinase activity
CHR53_RS03195	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CHR53_RS03205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHR53_RS03210	COG0805	protein transport
CHR53_RS03220	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CHR53_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR53_RS03260	COG0733	neurotransmitter:sodium symporter activity
CHR53_RS03265	COG1268	BioY protein
CHR53_RS03270	COG2199	diguanylate cyclase activity
CHR53_RS03275	COG1115	amino acid carrier protein
CHR53_RS03280	COG0590	tRNA wobble adenosine to inosine editing
CHR53_RS03285	COG0656	L-ascorbic acid biosynthetic process
CHR53_RS03295	COG1131	(ABC) transporter
CHR53_RS03315	COG1834	amidinotransferase
CHR53_RS03325	COG4187	Peptidase family M20/M25/M40
CHR53_RS03330	COG0833	amino acid
CHR53_RS03335	COG1823	symporter activity
CHR53_RS03370	COG3209	COG3209 Rhs family protein
CHR53_RS03395	COG1442	glycosyl transferase family 8
CHR53_RS03405	COG1442	glycosyl transferase family 8
CHR53_RS03415	COG1595	DNA-templated transcription, initiation
CHR53_RS03425	COG0436	Aminotransferase
CHR53_RS03430	COG1522	sequence-specific DNA binding
CHR53_RS03435	COG1473	amidohydrolase
CHR53_RS03440	COG1288	antiporter activity
CHR53_RS03455	COG0583	DNA-binding transcription factor activity
CHR53_RS03505	COG0613	PHP domain protein
CHR53_RS03510	COG0463	Glycosyl transferase, family 2
CHR53_RS03525	COG0730	response to heat
CHR53_RS03530	COG0529	Catalyzes the synthesis of activated sulfate
CHR53_RS03555	COG0189	ligase activity
CHR53_RS03565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHR53_RS03575	COG0189	ligase activity
CHR53_RS03580	COG3540	Alkaline phosphatase
CHR53_RS03585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHR53_RS03590	COG0805	protein transport
CHR53_RS03595	COG1704	LemA family
CHR53_RS03610	COG2972	Histidine kinase
CHR53_RS03620	COG1653	transport
CHR53_RS03625	COG1175	transmembrane transport
CHR53_RS03630	COG0395	ABC-type sugar transport system, permease component
CHR53_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS03650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS03655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS03660	COG1653	transport
CHR53_RS03670	COG0395	ABC-type sugar transport system, permease component
CHR53_RS03675	COG3250	beta-galactosidase activity
CHR53_RS03680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CHR53_RS03685	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CHR53_RS03690	COG2017	converts alpha-aldose to the beta-anomer
CHR53_RS03695	COG1609	Transcriptional regulator
CHR53_RS03700	COG0833	amino acid
CHR53_RS03705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS03710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS03730	COG1725	Transcriptional regulator
CHR53_RS03735	COG1131	(ABC) transporter
CHR53_RS03745	COG1595	DNA-templated transcription, initiation
CHR53_RS03750	COG0586	Pfam SNARE associated Golgi protein
CHR53_RS03760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHR53_RS03765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHR53_RS03770	COG1136	(ABC) transporter
CHR53_RS03775	COG1136	(ABC) transporter
CHR53_RS03775	COG0577	efflux transmembrane transporter activity
CHR53_RS03780	COG0745	RESPONSE REGULATOR receiver
CHR53_RS03785	COG5002	protein histidine kinase activity
CHR53_RS03805	COG1473	amidohydrolase
CHR53_RS03810	COG1757	Na H antiporter
CHR53_RS03840	COG1473	amidohydrolase
CHR53_RS03860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CHR53_RS03865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CHR53_RS03875	COG2244	polysaccharide biosynthetic process
CHR53_RS03880	COG0297	glycogen (starch) synthase activity
CHR53_RS03880	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS03885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CHR53_RS03890	COG3307	-O-antigen
CHR53_RS03895	COG3206	protein involved in exopolysaccharide biosynthesis
CHR53_RS03900	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS03905	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS03925	COG1854	S-ribosylhomocysteine lyase activity
CHR53_RS03935	COG1388	LysM domain
CHR53_RS03935	COG3858	chitin binding
CHR53_RS03950	COG1840	ABC-type Fe3 transport system, periplasmic component
CHR53_RS03955	COG3842	ATPase activity
CHR53_RS03960	COG4149	molybdate abc transporter
CHR53_RS03965	COG0165	Argininosuccinate lyase
CHR53_RS03970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHR53_RS03975	COG1757	Na H antiporter
CHR53_RS03985	COG0746	molybdenum cofactor guanylyltransferase activity
CHR53_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS04000	COG2076	Multidrug Resistance protein
CHR53_RS04005	COG2076	Multidrug Resistance protein
CHR53_RS04010	COG1309	transcriptional regulator
CHR53_RS04015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHR53_RS04030	COG0697	spore germination
CHR53_RS04035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS04055	COG1595	DNA-templated transcription, initiation
CHR53_RS04060	COG0590	tRNA wobble adenosine to inosine editing
CHR53_RS04065	COG1131	(ABC) transporter
CHR53_RS04090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS04105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHR53_RS04110	COG1193	negative regulation of DNA recombination
CHR53_RS04130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CHR53_RS04145	COG3541	Predicted nucleotidyltransferase
CHR53_RS04165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CHR53_RS04185	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS04190	COG0671	phosphoesterase, PA-phosphatase related
CHR53_RS04225	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CHR53_RS04230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHR53_RS04235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHR53_RS04240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHR53_RS04245	COG1120	ATPase activity
CHR53_RS04275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHR53_RS04285	COG2860	membrane
CHR53_RS04295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHR53_RS04300	COG2323	membrane
CHR53_RS04360	COG0456	acetyltransferase
CHR53_RS04365	COG2207	Transcriptional regulator
CHR53_RS04365	COG3708	Transcriptional regulator
CHR53_RS04375	COG1902	pentaerythritol trinitrate reductase activity
CHR53_RS04385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHR53_RS04395	COG1607	acyl-coa hydrolase
CHR53_RS04400	COG0322	excinuclease ABC activity
CHR53_RS04450	COG0531	amino acid
CHR53_RS04465	COG0768	penicillin binding
CHR53_RS04470	COG2367	Beta-lactamase
CHR53_RS04490	COG0561	phosphatase activity
CHR53_RS04500	COG0431	NADPH-dependent FMN reductase
CHR53_RS04510	COG0400	carboxylic ester hydrolase activity
CHR53_RS04515	COG1764	response to oxidative stress
CHR53_RS04520	COG0655	NAD(P)H dehydrogenase (quinone) activity
CHR53_RS04545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHR53_RS04555	COG0346	lactoylglutathione lyase activity
CHR53_RS04570	COG0776	regulation of translation
CHR53_RS04580	COG1657	PFAM Prenyltransferase squalene oxidase
CHR53_RS04610	COG1802	Transcriptional regulator
CHR53_RS04615	COG0579	oxidoreductase
CHR53_RS04630	COG3829	transcription factor binding
CHR53_RS04640	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CHR53_RS04655	COG1113	amino acid transport
CHR53_RS04660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS04665	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS04670	COG0583	DNA-binding transcription factor activity
CHR53_RS04675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHR53_RS04680	COG2340	Cysteine-rich secretory protein family
CHR53_RS04685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CHR53_RS04685	COG1017	nitric oxide dioxygenase activity
CHR53_RS04690	COG0640	Transcriptional regulator
CHR53_RS04695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CHR53_RS04700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CHR53_RS04705	COG0039	L-malate dehydrogenase activity
CHR53_RS04730	COG2807	transmembrane transport
CHR53_RS04735	COG1473	amidohydrolase
CHR53_RS04755	COG0196	riboflavin kinase activity
CHR53_RS04765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS04770	COG1113	amino acid transport
CHR53_RS04800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHR53_RS04810	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR53_RS04815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHR53_RS04845	COG0693	protein deglycase activity
CHR53_RS04860	COG0194	GDP metabolic process
CHR53_RS04865	COG1876	peptidase activity
CHR53_RS04870	COG0534	Mate efflux family protein
CHR53_RS04875	COG2132	Multicopper oxidase
CHR53_RS04880	COG0697	spore germination
CHR53_RS04900	COG4682	membrane
CHR53_RS04905	COG0069	glutamate synthase activity
CHR53_RS04910	COG1289	transmembrane transporter activity
CHR53_RS04915	COG1473	amidohydrolase
CHR53_RS04920	COG1473	amidohydrolase
CHR53_RS04925	COG2258	MOSC domain
CHR53_RS04950	COG0277	FAD linked oxidase domain protein
CHR53_RS04955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR53_RS04955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR53_RS04975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHR53_RS04990	COG1011	Hydrolase
CHR53_RS04995	COG1073	alpha beta
CHR53_RS05000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CHR53_RS05005	COG1131	(ABC) transporter
CHR53_RS05020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS05035	COG0745	RESPONSE REGULATOR receiver
CHR53_RS05040	COG5002	protein histidine kinase activity
CHR53_RS05055	COG0772	Belongs to the SEDS family
CHR53_RS05065	COG1279	arginine transmembrane transporter activity
CHR53_RS05070	COG0582	viral genome integration into host DNA
CHR53_RS05080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHR53_RS05080	COG2111	Na H antiporter
CHR53_RS05085	COG1006	Multisubunit Na H antiporter MnhC subunit
CHR53_RS05090	COG0651	ATP synthesis coupled electron transport
CHR53_RS05095	COG1863	multisubunit Na H antiporter MnhE subunit
CHR53_RS05100	COG2212	antiporter activity
CHR53_RS05105	COG1320	monovalent cation:proton antiporter activity
CHR53_RS05115	COG1051	belongs to the nudix hydrolase family
CHR53_RS05120	COG2814	Major facilitator Superfamily
CHR53_RS05125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHR53_RS05140	COG2832	Protein of unknown function (DUF454)
CHR53_RS05145	COG0745	RESPONSE REGULATOR receiver
CHR53_RS05150	COG5002	protein histidine kinase activity
CHR53_RS05150	COG3850	Histidine kinase
CHR53_RS05170	COG3852	Histidine kinase
CHR53_RS05180	COG1595	DNA-templated transcription, initiation
CHR53_RS05210	COG0681	Belongs to the peptidase S26 family
CHR53_RS05215	COG2304	oxidoreductase activity
CHR53_RS05220	COG3340	Belongs to the peptidase S51 family
CHR53_RS05230	COG2808	Putative FMN-binding domain
CHR53_RS05235	COG0456	acetyltransferase
CHR53_RS05240	COG1846	Transcriptional regulator
CHR53_RS05270	COG1686	Belongs to the peptidase S11 family
CHR53_RS05275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CHR53_RS05280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CHR53_RS05285	COG1620	l-lactate permease
CHR53_RS05295	COG2186	Transcriptional regulator
CHR53_RS05300	COG0247	lactate metabolic process
CHR53_RS05305	COG1139	Iron-sulfur cluster binding protein
CHR53_RS05310	COG1556	Lactate utilization protein
CHR53_RS05325	COG1595	DNA-templated transcription, initiation
CHR53_RS05340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CHR53_RS05350	COG1122	ATPase activity
CHR53_RS05355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHR53_RS05360	COG0477	Major facilitator Superfamily
CHR53_RS05395	COG0745	RESPONSE REGULATOR receiver
CHR53_RS05400	COG5000	phosphorelay sensor kinase activity
CHR53_RS05400	COG5002	protein histidine kinase activity
CHR53_RS05430	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CHR53_RS05435	COG2329	Antibiotic biosynthesis monooxygenase
CHR53_RS05460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CHR53_RS05470	COG1176	ABC-type spermidine putrescine transport system, permease component I
CHR53_RS05475	COG3842	ATPase activity
CHR53_RS05485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS05490	COG1309	transcriptional regulator
CHR53_RS05510	COG4708	membrane
CHR53_RS05515	COG1609	Transcriptional regulator
CHR53_RS05525	COG1621	beta-fructofuranosidase activity
CHR53_RS05550	COG1472	Belongs to the glycosyl hydrolase 3 family
CHR53_RS05560	COG1357	PFAM Pentapeptide repeats (8 copies)
CHR53_RS05565	COG2271	Major facilitator Superfamily
CHR53_RS05575	COG2076	Multidrug Resistance protein
CHR53_RS05580	COG2346	COG2346, Truncated hemoglobins
CHR53_RS05585	COG0366	Alpha amylase catalytic
CHR53_RS05595	COG2182	Extracellular solute-binding protein
CHR53_RS05600	COG1175	transmembrane transport
CHR53_RS05605	COG3833	ABC-type maltose transport systems, permease component
CHR53_RS05610	COG1609	Transcriptional regulator
CHR53_RS05615	COG0366	Alpha amylase catalytic
CHR53_RS05620	COG0534	Mate efflux family protein
CHR53_RS05630	COG1612	heme a metabolic process
CHR53_RS05645	COG0385	Bile acid
CHR53_RS05650	COG2233	PERMEase
CHR53_RS05655	COG3832	glyoxalase III activity
CHR53_RS05675	COG0166	Belongs to the GPI family
CHR53_RS05680	COG3189	MarR family transcriptional regulator
CHR53_RS05685	COG1272	protein, Hemolysin III
CHR53_RS05695	COG0697	spore germination
CHR53_RS05700	COG5434	Belongs to the glycosyl hydrolase 28 family
CHR53_RS05710	COG0456	acetyltransferase
CHR53_RS05715	COG0066	3-isopropylmalate dehydratase activity
CHR53_RS05720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CHR53_RS05725	COG0473	3-isopropylmalate dehydrogenase activity
CHR53_RS05730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHR53_RS05735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CHR53_RS05740	COG0440	acetolactate synthase activity
CHR53_RS05745	COG0028	Belongs to the TPP enzyme family
CHR53_RS05750	COG0129	dihydroxy-acid dehydratase activity
CHR53_RS05765	COG0765	amino acid transport
CHR53_RS05790	COG1690	Belongs to the RtcB family
CHR53_RS05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS05805	COG2814	Major facilitator Superfamily
CHR53_RS05815	COG0183	Belongs to the thiolase family
CHR53_RS05825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHR53_RS05835	COG0514	ATP-dependent DNA helicase (RecQ)
CHR53_RS05840	COG1388	LysM domain
CHR53_RS05840	COG3858	chitin binding
CHR53_RS05845	COG1131	(ABC) transporter
CHR53_RS05855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CHR53_RS05860	COG2814	Major facilitator Superfamily
CHR53_RS05865	COG2966	Psort location CytoplasmicMembrane, score
CHR53_RS05870	COG3610	response to peptide
CHR53_RS05875	COG4990	cell redox homeostasis
CHR53_RS05885	COG5002	protein histidine kinase activity
CHR53_RS05890	COG2199	diguanylate cyclase activity
CHR53_RS05890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CHR53_RS05895	COG3344	reverse transcriptase
CHR53_RS05915	COG0243	molybdopterin cofactor binding
CHR53_RS05950	COG2197	response regulator
CHR53_RS05960	COG4585	Histidine kinase
CHR53_RS05970	COG0673	inositol 2-dehydrogenase activity
CHR53_RS05975	COG1114	Component of the transport system for branched-chain amino acids
CHR53_RS05980	COG0348	domain, Protein
CHR53_RS05990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHR53_RS06015	COG0154	amidase activity
CHR53_RS06020	COG0723	plastoquinol--plastocyanin reductase activity
CHR53_RS06020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHR53_RS06030	COG2340	Cysteine-rich secretory protein family
CHR53_RS06045	COG4758	membrane
CHR53_RS06055	COG2197	response regulator
CHR53_RS06060	COG2822	iron ion transport
CHR53_RS06065	COG2837	iron assimilation
CHR53_RS06070	COG0672	)-iron permease
CHR53_RS06075	COG2244	polysaccharide biosynthetic process
CHR53_RS06085	COG0670	Belongs to the BI1 family
CHR53_RS06095	COG2309	aminopeptidase activity
CHR53_RS06105	COG2986	histidine ammonia-lyase
CHR53_RS06120	COG1522	sequence-specific DNA binding
CHR53_RS06120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR53_RS06130	COG1396	sequence-specific DNA binding
CHR53_RS06135	COG0024	Methionine aminopeptidase
CHR53_RS06140	COG4840	Belongs to the UPF0435 family
CHR53_RS06150	COG1295	ribonuclease BN
CHR53_RS06155	COG2217	Heavy metal translocating P-type atpase
CHR53_RS06160	COG0477	Major facilitator Superfamily
CHR53_RS06165	COG0387	Pfam Sodium calcium exchanger
CHR53_RS06200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHR53_RS06210	COG1174	glycine betaine transport
CHR53_RS06235	COG4807	Protein conserved in bacteria
CHR53_RS06240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS06245	COG3275	phosphorelay sensor kinase activity
CHR53_RS06250	COG3279	Response regulator of the LytR AlgR family
CHR53_RS06255	COG3162	membrane
CHR53_RS06260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS06270	COG0517	IMP dehydrogenase activity
CHR53_RS06270	COG4175	Glycine betaine
CHR53_RS06290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS06305	COG2234	aminopeptidase activity
CHR53_RS06315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHR53_RS06325	COG1473	amidohydrolase
CHR53_RS06330	COG2234	aminopeptidase activity
CHR53_RS06335	COG2814	Major facilitator Superfamily
CHR53_RS06350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHR53_RS06360	COG1113	amino acid transport
CHR53_RS06365	COG0701	Predicted permease
CHR53_RS06370	COG3689	TIGRFAM TIGR03943 family protein
CHR53_RS06375	COG1473	amidohydrolase
CHR53_RS06380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHR53_RS06385	COG3002	Belongs to the UPF0753 family
CHR53_RS06390	COG5609	conserved protein (DUF2294)
CHR53_RS06395	COG0288	reversible hydration of carbon dioxide
CHR53_RS06400	COG4191	Histidine kinase
CHR53_RS06405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CHR53_RS06410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CHR53_RS06445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CHR53_RS06445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CHR53_RS06450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHR53_RS06455	COG0010	Belongs to the arginase family
CHR53_RS06460	COG0673	inositol 2-dehydrogenase activity
CHR53_RS06465	COG3104	oligopeptide transport
CHR53_RS06475	COG0789	Transcriptional regulator
CHR53_RS06480	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS06485	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS06490	COG0747	negative chemotaxis
CHR53_RS06495	COG0601	transmembrane transport
CHR53_RS06500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS06505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CHR53_RS06510	COG0710	3-dehydroquinate dehydratase activity
CHR53_RS06520	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS06520	COG1525	nuclease
CHR53_RS06520	COG4085	toxin activity
CHR53_RS06525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CHR53_RS06530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CHR53_RS06535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CHR53_RS06540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHR53_RS06545	COG0505	Belongs to the CarA family
CHR53_RS06550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CHR53_RS06555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHR53_RS06560	COG0137	argininosuccinate synthase activity
CHR53_RS06565	COG0165	Argininosuccinate lyase
CHR53_RS06570	COG3153	acetyltransferase
CHR53_RS06570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHR53_RS06575	COG0456	acetyltransferase
CHR53_RS06585	COG0460	homoserine dehydrogenase
CHR53_RS06605	COG2137	regulation of response to DNA damage stimulus
CHR53_RS06630	COG1988	membrane-bound metal-dependent
CHR53_RS06635	COG1194	a g-specific adenine glycosylase
CHR53_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS06665	COG1132	(ABC) transporter
CHR53_RS06670	COG4129	membrane
CHR53_RS06675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CHR53_RS06680	COG4555	ABC transporter
CHR53_RS06700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CHR53_RS06705	COG0735	belongs to the Fur family
CHR53_RS06850	COG1742	UPF0060 membrane protein
CHR53_RS06855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CHR53_RS06860	COG1683	Conserved Protein
CHR53_RS06865	COG2211	Major facilitator Superfamily
CHR53_RS06890	COG3382	B3 4 domain protein
CHR53_RS06895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CHR53_RS06905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CHR53_RS06910	COG0778	Nitroreductase
CHR53_RS06915	COG2766	serine protein kinase
CHR53_RS06920	COG2718	Belongs to the UPF0229 family
CHR53_RS07005	COG3655	Transcriptional regulator
CHR53_RS07040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR53_RS07040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR53_RS07085	COG1702	phosphate starvation-inducible protein PhoH
CHR53_RS07105	COG0756	dUTP diphosphatase activity
CHR53_RS07110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CHR53_RS07115	COG3584	3D domain protein
CHR53_RS07145	COG4474	Belongs to the UPF0398 family
CHR53_RS07285	COG1652	LysM domain
CHR53_RS07300	COG3628	GPW Gp25 family protein
CHR53_RS07305	COG3299	homolog of phage Mu protein gp47
CHR53_RS07335	COG3409	Peptidoglycan-binding domain 1 protein
CHR53_RS07370	COG0739	heme binding
CHR53_RS07390	COG2340	Cysteine-rich secretory protein family
CHR53_RS07395	COG5002	protein histidine kinase activity
CHR53_RS07405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CHR53_RS07410	COG0363	glucosamine-6-phosphate deaminase activity
CHR53_RS07415	COG2188	Transcriptional regulator
CHR53_RS07425	COG1940	carbohydrate kinase activity
CHR53_RS07430	COG1904	glucuronate isomerase
CHR53_RS07435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHR53_RS07445	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS07450	COG1606	tRNA processing
CHR53_RS07455	COG1070	Carbohydrate kinase
CHR53_RS07460	COG1691	(AIR) carboxylase
CHR53_RS07465	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CHR53_RS07470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CHR53_RS07500	COG2409	Drug exporters of the RND superfamily
CHR53_RS07505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CHR53_RS07510	COG0306	phosphate transporter
CHR53_RS07515	COG1392	Phosphate transport regulator
CHR53_RS07520	COG2261	transglycosylase associated protein
CHR53_RS07525	COG0564	pseudouridine synthase activity
CHR53_RS07535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHR53_RS07545	COG2866	Carboxypeptidase
CHR53_RS07550	COG2719	SpoVR family
CHR53_RS07560	COG3384	dioxygenase
CHR53_RS07565	COG2259	Doxx family
CHR53_RS07575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CHR53_RS07585	COG0686	Belongs to the AlaDH PNT family
CHR53_RS07590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CHR53_RS07590	COG2508	Transcriptional regulator
CHR53_RS07595	COG1113	amino acid transport
CHR53_RS07600	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CHR53_RS07610	COG2733	membrane
CHR53_RS07620	COG4841	protein insertion into membrane
CHR53_RS07640	COG1253	flavin adenine dinucleotide binding
CHR53_RS07645	COG0789	Transcriptional regulator
CHR53_RS07650	COG1253	flavin adenine dinucleotide binding
CHR53_RS07655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS07660	COG3859	Proton-coupled thiamine transporter YuaJ
CHR53_RS07685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR53_RS07705	COG1132	(ABC) transporter
CHR53_RS07710	COG1132	(ABC) transporter
CHR53_RS07715	COG0114	fumarate hydratase activity
CHR53_RS07730	COG3842	ATPase activity
CHR53_RS07735	COG2508	Transcriptional regulator
CHR53_RS07755	COG0189	ligase activity
CHR53_RS07760	COG0189	ligase activity
CHR53_RS07770	COG3679	Belongs to the UPF0342 family
CHR53_RS07775	COG0561	phosphatase activity
CHR53_RS07780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHR53_RS07790	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS07795	COG1024	Enoyl-CoA hydratase
CHR53_RS07805	COG4152	abc transporter atp-binding protein
CHR53_RS07810	COG1668	transmembrane transport
CHR53_RS07815	COG0420	3'-5' exonuclease activity
CHR53_RS07820	COG4717	serine-type aminopeptidase activity
CHR53_RS07825	COG3481	metal-dependent phosphohydrolase, HD sub domain
CHR53_RS07835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHR53_RS07855	COG1846	Transcriptional regulator
CHR53_RS07865	COG0537	adenosine 5'-monophosphoramidase activity
CHR53_RS07870	COG1131	(ABC) transporter
CHR53_RS07875	COG4473	ABC transporter
CHR53_RS07885	COG3069	C4-dicarboxylate transmembrane transporter activity
CHR53_RS07890	COG2329	Antibiotic biosynthesis monooxygenase
CHR53_RS07895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CHR53_RS07900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CHR53_RS07905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CHR53_RS07910	COG1511	domain protein
CHR53_RS07915	COG1234	tRNA 3'-trailer cleavage
CHR53_RS07920	COG0095	Lipoate-protein ligase
CHR53_RS07925	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS07930	COG1024	Enoyl-CoA hydratase
CHR53_RS07935	COG0501	Belongs to the peptidase M48B family
CHR53_RS07945	COG4903	ComK protein
CHR53_RS07960	COG0398	Pfam SNARE associated Golgi protein
CHR53_RS07970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CHR53_RS08010	COG0179	Fumarylacetoacetate (FAA) hydrolase
CHR53_RS08035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHR53_RS08045	COG1874	Beta-galactosidase
CHR53_RS08045	COG0366	Alpha amylase catalytic
CHR53_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS08055	COG1666	GTP binding
CHR53_RS08060	COG2996	Protein conserved in bacteria
CHR53_RS08070	COG1307	EDD domain protein, DegV family
CHR53_RS08075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS08090	COG0561	phosphatase activity
CHR53_RS08095	COG2151	metal-sulfur cluster biosynthetic enzyme
CHR53_RS08105	COG0535	radical SAM domain protein
CHR53_RS08110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHR53_RS08115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CHR53_RS08120	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CHR53_RS08125	COG0303	'Molybdopterin
CHR53_RS08130	COG1763	Mo-molybdopterin cofactor biosynthetic process
CHR53_RS08140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHR53_RS08150	COG0542	response to heat
CHR53_RS08160	COG2267	carboxylic ester hydrolase activity
CHR53_RS08170	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR53_RS08185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR53_RS08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHR53_RS08195	COG5504	Zn-dependent protease
CHR53_RS08200	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS08205	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS08210	COG0747	negative chemotaxis
CHR53_RS08215	COG0601	transmembrane transport
CHR53_RS08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS08230	COG0180	Tryptophanyl-tRNA synthetase
CHR53_RS08235	COG4166	transmembrane transport
CHR53_RS08240	COG0601	transmembrane transport
CHR53_RS08245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS08250	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS08255	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS08265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS08275	COG1393	Belongs to the ArsC family
CHR53_RS08280	COG4862	establishment of competence for transformation
CHR53_RS08285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHR53_RS08295	COG1164	Oligoendopeptidase f
CHR53_RS08305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CHR53_RS08310	COG2346	COG2346, Truncated hemoglobins
CHR53_RS08315	COG4116	CYTH
CHR53_RS08325	COG2357	RelA SpoT domain protein
CHR53_RS08335	COG0564	pseudouridine synthase activity
CHR53_RS08340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHR53_RS08345	COG0475	glutathione-regulated potassium exporter activity
CHR53_RS08345	COG0569	domain protein
CHR53_RS08350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CHR53_RS08380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR53_RS08400	COG0210	DNA helicase
CHR53_RS08405	COG2153	protein acetylation
CHR53_RS08410	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CHR53_RS08415	COG2382	esterase
CHR53_RS08445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CHR53_RS08450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHR53_RS08455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHR53_RS08460	COG4989	oxidoreductase activity
CHR53_RS08480	COG3239	Fatty acid desaturase
CHR53_RS08485	COG4585	Histidine kinase
CHR53_RS08490	COG2197	response regulator
CHR53_RS08495	COG2267	carboxylic ester hydrolase activity
CHR53_RS08505	COG2364	Membrane
CHR53_RS08520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CHR53_RS08525	COG0697	spore germination
CHR53_RS08550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHR53_RS08555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CHR53_RS08560	COG1191	sigma factor activity
CHR53_RS08590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CHR53_RS08595	COG0674	pyruvate-flavodoxin oxidoreductase activity
CHR53_RS08600	COG5002	protein histidine kinase activity
CHR53_RS08605	COG0436	Aminotransferase
CHR53_RS08620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CHR53_RS08625	COG0644	oxidoreductase
CHR53_RS08640	COG2223	nitrite transmembrane transporter activity
CHR53_RS08645	COG3852	Histidine kinase
CHR53_RS08650	COG1846	Transcriptional regulator
CHR53_RS08660	COG0542	response to heat
CHR53_RS08665	COG3949	Membrane
CHR53_RS08675	COG4873	Protein conserved in bacteria
CHR53_RS08685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CHR53_RS08690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHR53_RS08695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CHR53_RS08700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CHR53_RS08710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHR53_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS08725	COG2084	Dehydrogenase
CHR53_RS08735	COG0436	Aminotransferase
CHR53_RS08745	COG1408	metallophosphoesterase
CHR53_RS08750	COG4990	cell redox homeostasis
CHR53_RS08755	COG2200	EAL domain
CHR53_RS08765	COG4703	Protein of unknown function (DUF1797)
CHR53_RS08770	COG0517	IMP dehydrogenase activity
CHR53_RS08775	COG0477	Major facilitator Superfamily
CHR53_RS08780	COG0583	DNA-binding transcription factor activity
CHR53_RS08785	COG2171	N-acyltransferase activity
CHR53_RS08790	COG1473	amidohydrolase
CHR53_RS08795	COG0450	alkyl hydroperoxide reductase
CHR53_RS08800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS08810	COG0569	domain protein
CHR53_RS08820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CHR53_RS08825	COG5503	Protein of unknown function (DUF1447)
CHR53_RS08830	COG0561	phosphatase activity
CHR53_RS08835	COG0242	peptide deformylase activity
CHR53_RS08850	COG0022	dehydrogenase e1 component
CHR53_RS08885	COG1982	Orn Lys Arg decarboxylase major
CHR53_RS08895	COG4476	Belongs to the UPF0223 family
CHR53_RS08900	COG4493	Belongs to the UPF0637 family
CHR53_RS08910	COG0483	inositol monophosphate 1-phosphatase activity
CHR53_RS08920	COG1217	gtp-binding protein TYPA
CHR53_RS08935	COG4896	Protein conserved in bacteria
CHR53_RS08950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CHR53_RS08955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CHR53_RS08965	COG0772	Belongs to the SEDS family
CHR53_RS08970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CHR53_RS08975	COG1612	heme a metabolic process
CHR53_RS08980	COG0109	protoheme IX farnesyltransferase activity
CHR53_RS09005	COG3336	cytochrome c oxidase
CHR53_RS09020	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CHR53_RS09025	COG2340	Cysteine-rich secretory protein family
CHR53_RS09045	COG3679	Belongs to the UPF0342 family
CHR53_RS09050	COG4471	UPF0298 protein
CHR53_RS09055	COG0742	ribosomal rna small subunit methyltransferase
CHR53_RS09060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CHR53_RS09065	COG3314	Sporulation integral membrane protein YlbJ
CHR53_RS09070	COG1752	Esterase of the alpha-beta hydrolase superfamily
CHR53_RS09075	COG3480	Lon protease (S16) C-terminal proteolytic domain
CHR53_RS09080	COG1323	Belongs to the UPF0348 family
CHR53_RS09085	COG1399	metal-binding, possibly nucleic acid-binding protein
CHR53_RS09090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHR53_RS09095	COG1024	Enoyl-CoA hydratase
CHR53_RS09105	COG0454	-acetyltransferase
CHR53_RS09110	COG0439	Biotin carboxylase
CHR53_RS09115	COG0511	ligase activity, forming carbon-carbon bonds
CHR53_RS09120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHR53_RS09125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CHR53_RS09135	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CHR53_RS09140	COG2001	Belongs to the MraZ family
CHR53_RS09155	COG0768	penicillin binding
CHR53_RS09160	COG0768	penicillin binding
CHR53_RS09165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHR53_RS09175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHR53_RS09180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHR53_RS09185	COG0772	Belongs to the SEDS family
CHR53_RS09190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHR53_RS09195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHR53_RS09200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CHR53_RS09205	COG3879	Bacterial protein of unknown function (DUF881)
CHR53_RS09210	COG3879	Bacterial protein of unknown function (DUF881)
CHR53_RS09215	COG3856	small basic protein
CHR53_RS09220	COG0849	cell division
CHR53_RS09225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CHR53_RS09235	COG1191	sigma factor activity
CHR53_RS09240	COG1191	sigma factor activity
CHR53_RS09245	COG1873	PFAM PRC-barrel domain
CHR53_RS09255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CHR53_RS09260	COG1799	cell septum assembly
CHR53_RS09265	COG0762	integral membrane protein
CHR53_RS09270	COG2302	S4 RNA-binding domain
CHR53_RS09275	COG3599	regulation of cell shape
CHR53_RS09295	COG0564	pseudouridine synthase activity
CHR53_RS09300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CHR53_RS09315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CHR53_RS09335	COG0167	dihydroorotate dehydrogenase activity
CHR53_RS09340	COG0284	orotidine-5'-phosphate decarboxylase activity
CHR53_RS09345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHR53_RS09355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CHR53_RS09360	COG1561	YicC-like family, N-terminal region
CHR53_RS09375	COG1758	RNA polymerase activity
CHR53_RS09380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHR53_RS09385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHR53_RS09395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CHR53_RS09400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHR53_RS09400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHR53_RS09405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CHR53_RS09410	COG0631	protein serine/threonine phosphatase activity
CHR53_RS09415	COG0515	serine threonine protein kinase
CHR53_RS09415	COG2815	serine threonine protein kinase
CHR53_RS09420	COG1162	GTPase activity
CHR53_RS09425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CHR53_RS09430	COG1564	THIamine pyrophosphokinase
CHR53_RS09440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHR53_RS09445	COG1302	Protein conserved in bacteria
CHR53_RS09450	COG1461	Dihydroxyacetone kinase
CHR53_RS09455	COG1760	l-serine dehydratase
CHR53_RS09460	COG1760	l-serine dehydratase
CHR53_RS09465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHR53_RS09470	COG1349	DNA-binding transcription factor activity
CHR53_RS09475	COG0416	fatty acid biosynthetic process
CHR53_RS09480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHR53_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS09490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHR53_RS09495	COG0571	ribonuclease III activity
CHR53_RS09500	COG1196	nuclear chromosome segregation
CHR53_RS09505	COG0552	protein localization to endoplasmic reticulum
CHR53_RS09510	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CHR53_RS09515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHR53_RS09525	COG1837	Belongs to the UPF0109 family
CHR53_RS09535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHR53_RS09540	COG0336	Belongs to the RNA methyltransferase TrmD family
CHR53_RS09545	COG0335	large ribosomal subunit rRNA binding
CHR53_RS09555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHR53_RS09565	COG0045	succinate-CoA ligase (ADP-forming) activity
CHR53_RS09570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CHR53_RS09575	COG0758	DNA mediated transformation
CHR53_RS09580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHR53_RS09585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CHR53_RS09595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CHR53_RS09600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CHR53_RS09605	COG0052	Belongs to the universal ribosomal protein uS2 family
CHR53_RS09615	COG0528	UMP kinase activity
CHR53_RS09620	COG0233	cytoplasmic translational termination
CHR53_RS09630	COG4589	Belongs to the CDS family
CHR53_RS09635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CHR53_RS09640	COG0750	zinc metalloprotease
CHR53_RS09645	COG2176	DNA-directed DNA polymerase activity
CHR53_RS09650	COG0779	Required for maturation of 30S ribosomal subunits
CHR53_RS09655	COG0195	Participates in both transcription termination and antitermination
CHR53_RS09660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CHR53_RS09665	COG1358	cellular component organization or biogenesis
CHR53_RS09675	COG1550	Protein conserved in bacteria
CHR53_RS09680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHR53_RS09685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHR53_RS09690	COG0196	riboflavin kinase activity
CHR53_RS09695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHR53_RS09700	COG1185	polyribonucleotide nucleotidyltransferase activity
CHR53_RS09705	COG0726	polysaccharide deacetylase
CHR53_RS09710	COG0612	Peptidase, M16
CHR53_RS09715	COG1873	PFAM PRC-barrel domain
CHR53_RS09720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS09725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHR53_RS09730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHR53_RS09735	COG0527	aspartate kinase activity
CHR53_RS09740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR53_RS09745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CHR53_RS09750	COG0740	serine-type endopeptidase activity
CHR53_RS09760	COG4980	gas vesicle protein
CHR53_RS09760	COG1674	ftsk spoiiie
CHR53_RS09765	COG2188	Transcriptional regulator
CHR53_RS09770	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR53_RS09775	COG3845	ABC transporter
CHR53_RS09780	COG4603	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS09785	COG1079	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS09790	COG0612	Peptidase, M16
CHR53_RS09795	COG0612	Peptidase, M16
CHR53_RS09800	COG0300	oxidoreductase activity
CHR53_RS09815	COG1426	Protein conserved in bacteria
CHR53_RS09820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHR53_RS09825	COG1546	Belongs to the CinA family
CHR53_RS09825	COG1058	Belongs to the CinA family
CHR53_RS09855	COG1692	metallophosphoesterase
CHR53_RS09860	COG2359	stage V sporulation protein S
CHR53_RS09865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CHR53_RS09865	COG0674	pyruvate-flavodoxin oxidoreductase activity
CHR53_RS09870	COG1013	pyruvate-flavodoxin oxidoreductase activity
CHR53_RS09875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHR53_RS09880	COG4550	Control of competence regulator ComK, YlbF/YmcA
CHR53_RS09895	COG0583	DNA-binding transcription factor activity
CHR53_RS09910	COG0196	riboflavin kinase activity
CHR53_RS09915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR53_RS09920	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS09940	COG0789	Transcriptional regulator
CHR53_RS09940	COG4978	Transcriptional regulator
CHR53_RS09945	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS09950	COG0179	Fumarylacetoacetate (FAA) hydrolase
CHR53_RS10010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CHR53_RS10015	COG1234	tRNA 3'-trailer cleavage
CHR53_RS10025	COG2271	Major facilitator Superfamily
CHR53_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS10040	COG0531	amino acid
CHR53_RS10045	COG1234	tRNA 3'-trailer cleavage
CHR53_RS10050	COG1940	carbohydrate kinase activity
CHR53_RS10055	COG2059	Chromate
CHR53_RS10060	COG2059	Chromate
CHR53_RS10065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS10070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CHR53_RS10075	COG3829	transcription factor binding
CHR53_RS10080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CHR53_RS10085	COG3314	Sporulation integral membrane protein YlbJ
CHR53_RS10090	COG1228	amidohydrolase
CHR53_RS10095	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHR53_RS10100	COG2056	Na+-H+ antiporter family
CHR53_RS10105	COG2986	histidine ammonia-lyase
CHR53_RS10110	COG1119	ATPase activity
CHR53_RS10115	COG1280	lysine exporter protein (LysE YggA)
CHR53_RS10120	COG2368	4-hydroxyphenylacetate
CHR53_RS10155	COG2814	Major facilitator Superfamily
CHR53_RS10160	COG0789	Transcriptional regulator
CHR53_RS10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS10195	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR53_RS10210	COG1937	Protein conserved in bacteria
CHR53_RS10215	COG2210	Belongs to the sulfur carrier protein TusA family
CHR53_RS10220	COG1054	Belongs to the UPF0176 family
CHR53_RS10225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS10225	COG0425	Belongs to the sulfur carrier protein TusA family
CHR53_RS10230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS10230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS10235	COG0425	Belongs to the sulfur carrier protein TusA family
CHR53_RS10255	COG1388	LysM domain
CHR53_RS10260	COG5002	protein histidine kinase activity
CHR53_RS10265	COG0745	RESPONSE REGULATOR receiver
CHR53_RS10270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHR53_RS10275	COG3871	stress protein (general stress protein 26)
CHR53_RS10280	COG2155	Conserved Protein
CHR53_RS10285	COG1404	Belongs to the peptidase S8 family
CHR53_RS10300	COG5522	Integral membrane protein (intg_mem_TP0381)
CHR53_RS10305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CHR53_RS10310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHR53_RS10315	COG1077	Cell shape determining protein MreB Mrl
CHR53_RS10320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHR53_RS10325	COG1923	regulation of RNA biosynthetic process
CHR53_RS10330	COG0464	growth
CHR53_RS10335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHR53_RS10340	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CHR53_RS10345	COG0789	Transcriptional regulator
CHR53_RS10350	COG0174	glutamine synthetase
CHR53_RS10360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHR53_RS10365	COG1388	LysM domain
CHR53_RS10370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CHR53_RS10390	COG3763	UPF0154 protein
CHR53_RS10395	COG1132	(ABC) transporter
CHR53_RS10400	COG1132	(ABC) transporter
CHR53_RS10410	COG0785	Cytochrome C biogenesis protein
CHR53_RS10415	COG4846	Membrane protein involved in cytochrome C biogenesis
CHR53_RS10430	COG0322	excinuclease ABC activity
CHR53_RS10480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CHR53_RS10510	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CHR53_RS10520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CHR53_RS10530	COG1473	amidohydrolase
CHR53_RS10535	COG2205	protein histidine kinase activity
CHR53_RS10555	COG0475	glutathione-regulated potassium exporter activity
CHR53_RS10585	COG2814	Major facilitator Superfamily
CHR53_RS10600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS10605	COG4191	Histidine kinase
CHR53_RS10620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS10625	COG0656	L-ascorbic acid biosynthetic process
CHR53_RS10630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS10635	COG2814	Major facilitator Superfamily
CHR53_RS10645	COG1846	Transcriptional regulator
CHR53_RS10650	COG1027	Aspartate ammonia-lyase
CHR53_RS10660	COG2720	vancomycin resistance protein
CHR53_RS10670	COG1695	Transcriptional regulator
CHR53_RS10690	COG0659	secondary active sulfate transmembrane transporter activity
CHR53_RS10710	COG0419	ATPase involved in DNA repair
CHR53_RS10720	COG0110	maltose O-acetyltransferase activity
CHR53_RS10730	COG1573	uracil-dna glycosylase
CHR53_RS10735	COG0406	alpha-ribazole phosphatase activity
CHR53_RS10755	COG1914	H( )-stimulated, divalent metal cation uptake system
CHR53_RS10760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CHR53_RS10765	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CHR53_RS10770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHR53_RS10780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHR53_RS10790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHR53_RS10795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS10800	COG2986	histidine ammonia-lyase
CHR53_RS10810	COG2207	Transcriptional regulator
CHR53_RS10815	COG2056	Na+-H+ antiporter family
CHR53_RS10820	COG1733	regulation of RNA biosynthetic process
CHR53_RS10830	COG2310	stress, protein
CHR53_RS10835	COG2362	D-Aminopeptidase
CHR53_RS10840	COG0601	transmembrane transport
CHR53_RS10845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS10850	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS10855	COG4166	transmembrane transport
CHR53_RS10860	COG1619	proteins homologs of microcin C7 resistance protein MccF
CHR53_RS10865	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS10870	COG0791	NLP P60 protein
CHR53_RS10875	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS10885	COG1115	amino acid carrier protein
CHR53_RS10890	COG2409	Drug exporters of the RND superfamily
CHR53_RS10890	COG1033	growth of symbiont in host cell
CHR53_RS10895	COG1846	Transcriptional regulator
CHR53_RS10905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHR53_RS10925	COG1131	(ABC) transporter
CHR53_RS10930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CHR53_RS10940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHR53_RS10945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CHR53_RS10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHR53_RS10955	COG1696	Membrane protein involved in D-alanine export
CHR53_RS10960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CHR53_RS10970	COG1363	Peptidase, m42
CHR53_RS10980	COG0598	Magnesium transport protein CorA
CHR53_RS10985	COG0697	spore germination
CHR53_RS11000	COG0535	radical SAM domain protein
CHR53_RS11005	COG0398	Pfam SNARE associated Golgi protein
CHR53_RS11015	COG0477	Major facilitator Superfamily
CHR53_RS11030	COG2080	2 iron, 2 sulfur cluster binding
CHR53_RS11035	COG0768	penicillin binding
CHR53_RS11060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CHR53_RS11065	COG0861	Integral membrane protein TerC family
CHR53_RS11070	COG5002	protein histidine kinase activity
CHR53_RS11075	COG0745	RESPONSE REGULATOR receiver
CHR53_RS11080	COG0671	phosphoesterase, PA-phosphatase related
CHR53_RS11085	COG1183	phosphatidylcholine synthase activity
CHR53_RS11090	COG1132	(ABC) transporter
CHR53_RS11095	COG0561	phosphatase activity
CHR53_RS11100	COG0753	catalase activity
CHR53_RS11110	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS11125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHR53_RS11125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHR53_RS11130	COG0307	riboflavin synthase, alpha
CHR53_RS11135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR53_RS11135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR53_RS11140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CHR53_RS11145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHR53_RS11150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHR53_RS11155	COG1120	ATPase activity
CHR53_RS11160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CHR53_RS11170	COG1492	cobalamin metabolic process
CHR53_RS11175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CHR53_RS11190	COG2096	Adenosyltransferase
CHR53_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR53_RS11210	COG1136	(ABC) transporter
CHR53_RS11215	COG0577	efflux transmembrane transporter activity
CHR53_RS11235	COG0697	spore germination
CHR53_RS11245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CHR53_RS11250	COG5002	protein histidine kinase activity
CHR53_RS11255	COG1247	-acetyltransferase
CHR53_RS11265	COG1227	inorganic diphosphatase activity
CHR53_RS11280	COG2818	Glycosylase
CHR53_RS11290	COG2357	RelA SpoT domain protein
CHR53_RS11300	COG2270	Major facilitator Superfamily
CHR53_RS11310	COG1329	Transcriptional regulator
CHR53_RS11330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CHR53_RS11335	COG1228	amidohydrolase
CHR53_RS11340	COG3314	Sporulation integral membrane protein YlbJ
CHR53_RS11365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHR53_RS11370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHR53_RS11375	COG2234	aminopeptidase activity
CHR53_RS11385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CHR53_RS11390	COG0351	phosphomethylpyrimidine kinase
CHR53_RS11405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS11410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CHR53_RS11415	COG1116	anion transmembrane transporter activity
CHR53_RS11420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR53_RS11425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHR53_RS11430	COG1301	dicarboxylic acid transport
CHR53_RS11440	COG3290	protein histidine kinase activity
CHR53_RS11470	COG0534	Mate efflux family protein
CHR53_RS11500	COG2112	serine threonine protein kinase
CHR53_RS11505	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS11510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHR53_RS11535	COG0577	efflux transmembrane transporter activity
CHR53_RS11540	COG1136	(ABC) transporter
CHR53_RS11545	COG2205	protein histidine kinase activity
CHR53_RS11550	COG0745	RESPONSE REGULATOR receiver
CHR53_RS11555	COG1966	Carbon starvation protein
CHR53_RS11595	COG1164	Oligoendopeptidase f
CHR53_RS11615	COG0175	sulfate reduction
CHR53_RS11620	COG0306	phosphate transporter
CHR53_RS11625	COG2046	Belongs to the sulfate adenylyltransferase family
CHR53_RS11630	COG0529	Catalyzes the synthesis of activated sulfate
CHR53_RS11645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CHR53_RS11650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CHR53_RS11655	COG0402	S-adenosylhomocysteine deaminase activity
CHR53_RS11660	COG0412	Dienelactone hydrolase
CHR53_RS11665	COG2217	Heavy metal translocating P-type atpase
CHR53_RS11670	COG2936	dipeptidyl-peptidase activity
CHR53_RS11680	COG2105	PFAM AIG2 family protein
CHR53_RS11680	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CHR53_RS11685	COG0484	heat shock protein binding
CHR53_RS11695	COG1404	Belongs to the peptidase S8 family
CHR53_RS11700	COG1183	phosphatidylcholine synthase activity
CHR53_RS11705	COG2066	Belongs to the glutaminase family
CHR53_RS11710	COG0488	(ABC) transporter
CHR53_RS11725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR53_RS11750	COG0697	spore germination
CHR53_RS11765	COG2267	carboxylic ester hydrolase activity
CHR53_RS11775	COG3858	chitin binding
CHR53_RS11780	COG1114	Component of the transport system for branched-chain amino acids
CHR53_RS11785	COG4895	conserved protein (DUF2196)
CHR53_RS11820	COG1388	LysM domain
CHR53_RS11820	COG0791	NLP P60 protein
CHR53_RS11850	COG0640	Transcriptional regulator
CHR53_RS11885	COG0745	RESPONSE REGULATOR receiver
CHR53_RS11890	COG2205	protein histidine kinase activity
CHR53_RS11895	COG2318	DinB family
CHR53_RS11905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CHR53_RS11910	COG1335	isochorismatase
CHR53_RS11915	COG1522	sequence-specific DNA binding
CHR53_RS11920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHR53_RS11940	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CHR53_RS11950	COG0154	amidase activity
CHR53_RS11965	COG1074	ATP-dependent DNA helicase activity
CHR53_RS11980	COG0745	RESPONSE REGULATOR receiver
CHR53_RS12010	COG0826	peptidase U32
CHR53_RS12015	COG1132	(ABC) transporter
CHR53_RS12020	COG1404	Belongs to the peptidase S8 family
CHR53_RS12085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHR53_RS12100	COG0671	phosphoesterase, PA-phosphatase related
CHR53_RS12105	COG0745	RESPONSE REGULATOR receiver
CHR53_RS12110	COG5002	protein histidine kinase activity
CHR53_RS12110	COG3850	Histidine kinase
CHR53_RS12115	COG0586	Pfam SNARE associated Golgi protein
CHR53_RS12135	COG3773	Cell wall hydrolase
CHR53_RS12140	COG3848	Pyruvate phosphate dikinase
CHR53_RS12140	COG0574	Belongs to the PEP-utilizing enzyme family
CHR53_RS12155	COG0456	acetyltransferase
CHR53_RS12190	COG0791	NLP P60 protein
CHR53_RS12200	COG0861	Integral membrane protein TerC family
CHR53_RS12205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CHR53_RS12210	COG1414	Transcriptional regulator
CHR53_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS12225	COG0179	Fumarylacetoacetate (FAA) hydrolase
CHR53_RS12235	COG2721	sulfolactate sulfo-lyase activity
CHR53_RS12245	COG2721	sulfolactate sulfo-lyase activity
CHR53_RS12250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS12255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS12260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHR53_RS12265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHR53_RS12270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS12280	COG0129	dihydroxy-acid dehydratase activity
CHR53_RS12285	COG1414	Transcriptional regulator
CHR53_RS12295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR53_RS12310	COG0346	lactoylglutathione lyase activity
CHR53_RS12325	COG1476	TRANSCRIPTIONal
CHR53_RS12340	COG0456	acetyltransferase
CHR53_RS12360	COG2234	aminopeptidase activity
CHR53_RS12365	COG2234	aminopeptidase activity
CHR53_RS12370	COG3706	GGDEF domain
CHR53_RS12375	COG2199	diguanylate cyclase activity
CHR53_RS12375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CHR53_RS12380	COG4841	protein insertion into membrane
CHR53_RS12385	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS12390	COG1283	sodium-dependent phosphate transmembrane transporter activity
CHR53_RS12405	COG0477	Major facilitator Superfamily
CHR53_RS12410	COG3842	ATPase activity
CHR53_RS12415	COG1178	ABC-type Fe3 transport system permease component
CHR53_RS12420	COG1840	ABC-type Fe3 transport system, periplasmic component
CHR53_RS12430	COG4176	ABC-type proline glycine betaine transport system permease component
CHR53_RS12440	COG1999	signal sequence binding
CHR53_RS12445	COG1595	DNA-templated transcription, initiation
CHR53_RS12465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CHR53_RS12475	COG0217	transcriptional regulatory protein
CHR53_RS12480	COG0697	spore germination
CHR53_RS12485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHR53_RS12500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CHR53_RS12505	COG2135	peptidase activity
CHR53_RS12510	COG2188	Transcriptional regulator
CHR53_RS12515	COG0366	Alpha amylase catalytic
CHR53_RS12520	COG1263	PTS System
CHR53_RS12520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR53_RS12525	COG0861	Integral membrane protein TerC family
CHR53_RS12540	COG3011	Protein conserved in bacteria
CHR53_RS12550	COG2070	2-Nitropropane dioxygenase
CHR53_RS12565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS12570	COG0765	amino acid transport
CHR53_RS12575	COG3048	D-serine ammonia-lyase activity
CHR53_RS12600	COG1533	DNA photolyase activity
CHR53_RS12605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS12605	COG0425	Belongs to the sulfur carrier protein TusA family
CHR53_RS12610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS12610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS12615	COG0730	response to heat
CHR53_RS12620	COG2210	Belongs to the sulfur carrier protein TusA family
CHR53_RS12635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS12655	COG2814	Major facilitator Superfamily
CHR53_RS12660	COG0488	(ABC) transporter
CHR53_RS12680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHR53_RS12695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CHR53_RS12735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CHR53_RS12740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS12760	COG0464	growth
CHR53_RS12765	COG0824	Thioesterase
CHR53_RS12775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHR53_RS12780	COG3852	Histidine kinase
CHR53_RS12785	COG1832	CoA-binding protein
CHR53_RS12790	COG0187	DNA topoisomerase II activity
CHR53_RS12795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHR53_RS12815	COG1132	(ABC) transporter
CHR53_RS12820	COG0745	RESPONSE REGULATOR receiver
CHR53_RS12825	COG2205	protein histidine kinase activity
CHR53_RS12830	COG1136	(ABC) transporter
CHR53_RS12835	COG0577	efflux transmembrane transporter activity
CHR53_RS12840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CHR53_RS12845	COG2252	PERMEase
CHR53_RS12855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CHR53_RS12855	COG3608	succinylglutamate desuccinylase aspartoacylase
CHR53_RS12860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CHR53_RS12870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHR53_RS12900	COG0163	prenyltransferase activity
CHR53_RS12935	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CHR53_RS12940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CHR53_RS12945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CHR53_RS12950	COG3665	Urea carboxylase-associated protein
CHR53_RS12955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS12960	COG0402	S-adenosylhomocysteine deaminase activity
CHR53_RS12965	COG4974	Belongs to the 'phage' integrase family
CHR53_RS12980	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHR53_RS12990	COG0402	S-adenosylhomocysteine deaminase activity
CHR53_RS12995	COG0402	S-adenosylhomocysteine deaminase activity
CHR53_RS13015	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHR53_RS13030	COG0697	spore germination
CHR53_RS13055	COG5577	PFAM Coat F domain
CHR53_RS13065	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHR53_RS13115	COG1714	RDD family
CHR53_RS13130	COG0714	Associated with various cellular activities
CHR53_RS13150	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS13165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHR53_RS13180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS13190	COG1114	Component of the transport system for branched-chain amino acids
CHR53_RS13195	COG3829	transcription factor binding
CHR53_RS13200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHR53_RS13205	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHR53_RS13235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHR53_RS13240	COG0655	NAD(P)H dehydrogenase (quinone) activity
CHR53_RS13245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CHR53_RS13270	COG0493	'glutamate synthase
CHR53_RS13275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS13280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHR53_RS13285	COG2056	Na+-H+ antiporter family
CHR53_RS13295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS13300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHR53_RS13305	COG2207	Transcriptional regulator
CHR53_RS13315	COG1116	anion transmembrane transporter activity
CHR53_RS13325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHR53_RS13330	COG2204	response regulator
CHR53_RS13345	COG3258	Cytochrome c
CHR53_RS13350	COG0425	Belongs to the sulfur carrier protein TusA family
CHR53_RS13355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS13370	COG2814	Major facilitator Superfamily
CHR53_RS13385	COG2234	aminopeptidase activity
CHR53_RS13395	COG1164	Oligoendopeptidase f
CHR53_RS13400	COG0716	FMN binding
CHR53_RS13405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHR53_RS13410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHR53_RS13425	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS13425	COG4085	toxin activity
CHR53_RS13425	COG1525	nuclease
CHR53_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS13445	COG2720	vancomycin resistance protein
CHR53_RS13455	COG0506	proline dehydrogenase activity
CHR53_RS13465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CHR53_RS13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS13480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS13510	COG2358	TRAP transporter, solute receptor (TAXI family
CHR53_RS13515	COG0312	modulator of DNA gyrase
CHR53_RS13520	COG0312	modulator of DNA gyrase
CHR53_RS13525	COG0778	Nitroreductase
CHR53_RS13525	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CHR53_RS13535	COG0028	Belongs to the TPP enzyme family
CHR53_RS13545	COG0512	Glutamine amidotransferase of anthranilate synthase
CHR53_RS13560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHR53_RS13565	COG0596	Alpha beta hydrolase
CHR53_RS13570	COG1090	epimerase
CHR53_RS13630	COG2235	arginine
CHR53_RS13640	COG0765	amino acid transport
CHR53_RS13645	COG1126	abc transporter atp-binding protein
CHR53_RS13650	COG2235	arginine
CHR53_RS13665	COG2226	methyltransferase
CHR53_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS13680	COG2610	gluconate transmembrane transporter activity
CHR53_RS13685	COG0583	DNA-binding transcription factor activity
CHR53_RS13690	COG2814	Major facilitator Superfamily
CHR53_RS13695	COG1566	PFAM secretion protein HlyD family protein
CHR53_RS13705	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CHR53_RS13725	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13735	COG3829	transcription factor binding
CHR53_RS13735	COG3290	protein histidine kinase activity
CHR53_RS13740	COG0405	Gamma-glutamyltransferase
CHR53_RS13770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CHR53_RS13775	COG1309	transcriptional regulator
CHR53_RS13810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CHR53_RS13840	COG0004	ammonium transporteR
CHR53_RS13845	COG0367	asparagine synthase
CHR53_RS13855	COG0069	glutamate synthase activity
CHR53_RS13855	COG0070	glutamate synthase
CHR53_RS13855	COG0067	glutamate synthase
CHR53_RS13860	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS13870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHR53_RS13880	COG0022	dehydrogenase e1 component
CHR53_RS13885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHR53_RS13895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS13895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHR53_RS13900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS13905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS13910	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS13930	COG2027	D-alanyl-D-alanine carboxypeptidase
CHR53_RS13950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CHR53_RS13955	COG3764	Sortase (surface protein transpeptidase)
CHR53_RS13970	COG2271	Major facilitator Superfamily
CHR53_RS13975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CHR53_RS13985	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS13990	COG0583	DNA-binding transcription factor activity
CHR53_RS13995	COG3852	Histidine kinase
CHR53_RS14020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS14025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHR53_RS14030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHR53_RS14035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHR53_RS14040	COG2318	DinB family
CHR53_RS14045	COG1733	regulation of RNA biosynthetic process
CHR53_RS14050	COG0778	Nitroreductase
CHR53_RS14085	COG1278	Cold shock
CHR53_RS14105	COG3973	AAA domain
CHR53_RS14115	COG2358	TRAP transporter, solute receptor (TAXI family
CHR53_RS14120	COG0513	Belongs to the DEAD box helicase family
CHR53_RS14130	COG0247	lactate metabolic process
CHR53_RS14135	COG0277	FAD linked oxidase domain protein
CHR53_RS14165	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CHR53_RS14175	COG3620	sequence-specific DNA binding
CHR53_RS14180	COG0534	Mate efflux family protein
CHR53_RS14185	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CHR53_RS14195	COG0154	amidase activity
CHR53_RS14200	COG2271	Major facilitator Superfamily
CHR53_RS14210	COG0028	Belongs to the TPP enzyme family
CHR53_RS14215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS14220	COG1414	Transcriptional regulator
CHR53_RS14225	COG1301	dicarboxylic acid transport
CHR53_RS14230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CHR53_RS14250	COG1396	sequence-specific DNA binding
CHR53_RS14285	COG1472	Belongs to the glycosyl hydrolase 3 family
CHR53_RS14295	COG0346	lactoylglutathione lyase activity
CHR53_RS14320	COG0666	response to abiotic stimulus
CHR53_RS14325	COG0590	tRNA wobble adenosine to inosine editing
CHR53_RS14330	COG2233	PERMEase
CHR53_RS14335	COG0583	DNA-binding transcription factor activity
CHR53_RS14350	COG2816	NAD+ diphosphatase activity
CHR53_RS14360	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CHR53_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS14380	COG0492	ferredoxin-NADP+ reductase activity
CHR53_RS14385	COG1959	2 iron, 2 sulfur cluster binding
CHR53_RS14410	COG5577	PFAM Coat F domain
CHR53_RS14415	COG1063	alcohol dehydrogenase
CHR53_RS14425	COG5577	PFAM Coat F domain
CHR53_RS14435	COG1335	isochorismatase
CHR53_RS14450	COG2890	protein-(glutamine-N5) methyltransferase activity
CHR53_RS14495	COG4319	ketosteroid isomerase
CHR53_RS14500	COG2391	methyltransferase activity
CHR53_RS14520	COG1278	Cold shock
CHR53_RS14530	COG3243	poly(R)-hydroxyalkanoic acid synthase
CHR53_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS14555	COG1278	Cold shock
CHR53_RS14570	COG1278	Cold shock
CHR53_RS14580	COG1278	Cold shock
CHR53_RS14590	COG0346	lactoylglutathione lyase activity
CHR53_RS14605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS14660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHR53_RS14675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CHR53_RS14710	COG1595	DNA-templated transcription, initiation
CHR53_RS14725	COG1309	transcriptional regulator
CHR53_RS14795	COG0681	Belongs to the peptidase S26 family
CHR53_RS14810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHR53_RS14835	COG1115	amino acid carrier protein
CHR53_RS14840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CHR53_RS14875	COG1609	Transcriptional regulator
CHR53_RS14880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CHR53_RS14900	COG1733	regulation of RNA biosynthetic process
CHR53_RS14925	COG0778	Nitroreductase
CHR53_RS15000	COG0662	Cupin 2, conserved barrel domain protein
CHR53_RS15045	COG0672	)-iron permease
CHR53_RS15075	COG1254	Belongs to the acylphosphatase family
CHR53_RS15125	COG2318	DinB family
CHR53_RS15160	COG1846	Transcriptional regulator
CHR53_RS15170	COG0776	regulation of translation
CHR53_RS15175	COG2318	DinB family
CHR53_RS15195	COG4974	Belongs to the 'phage' integrase family
CHR53_RS15210	COG4974	Belongs to the 'phage' integrase family
CHR53_RS15215	COG2226	methyltransferase
CHR53_RS15235	COG1278	Cold shock
CHR53_RS15260	COG0154	amidase activity
CHR53_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS15295	COG0477	Major facilitator Superfamily
CHR53_RS15300	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS15305	COG0686	Belongs to the AlaDH PNT family
CHR53_RS15305	COG0686	Belongs to the AlaDH PNT family
CHR53_RS15320	COG0247	lactate metabolic process
CHR53_RS15325	COG0277	FAD linked oxidase domain protein
CHR53_RS15330	COG2808	Putative FMN-binding domain
CHR53_RS15335	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS15340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS15355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS15365	COG0559	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS15375	COG0411	ABC transporter
CHR53_RS15390	COG3829	transcription factor binding
CHR53_RS15400	COG2814	Major facilitator Superfamily
CHR53_RS15460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CHR53_RS15490	COG0758	DNA mediated transformation
CHR53_RS15585	COG0346	lactoylglutathione lyase activity
CHR53_RS15615	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS15625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS15630	COG0601	transmembrane transport
CHR53_RS15635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHR53_RS15640	COG0747	negative chemotaxis
CHR53_RS15645	COG0473	3-isopropylmalate dehydrogenase activity
CHR53_RS15645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CHR53_RS15660	COG1595	DNA-templated transcription, initiation
CHR53_RS15690	COG1525	nuclease
CHR53_RS15700	COG0305	Participates in initiation and elongation during chromosome replication
CHR53_RS15710	COG2814	Major facilitator Superfamily
CHR53_RS15720	COG1705	Flagellar rod assembly protein muramidase FlgJ
CHR53_RS15730	COG0523	cobalamin synthesis protein
CHR53_RS15735	COG3443	Belongs to the bacterial solute-binding protein 9 family
CHR53_RS15735	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHR53_RS15740	COG0701	Predicted permease
CHR53_RS15750	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS15760	COG1053	succinate dehydrogenase
CHR53_RS15765	COG0583	DNA-binding transcription factor activity
CHR53_RS15770	COG3180	Ammonia monooxygenase
CHR53_RS15775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHR53_RS15780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR53_RS15800	COG0477	Major facilitator Superfamily
CHR53_RS15805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CHR53_RS15810	COG2427	Protein of unknown function (DUF1641)
CHR53_RS15815	COG3383	formate dehydrogenase (NAD+) activity
CHR53_RS15835	COG2207	Transcriptional regulator
CHR53_RS15845	COG0488	(ABC) transporter
CHR53_RS15860	COG0400	carboxylic ester hydrolase activity
CHR53_RS15865	COG0346	lactoylglutathione lyase activity
CHR53_RS15870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CHR53_RS15875	COG0346	lactoylglutathione lyase activity
CHR53_RS15880	COG2259	Doxx family
CHR53_RS15885	COG1846	Transcriptional regulator
CHR53_RS15910	COG2851	Citrate transporter
CHR53_RS15940	COG2323	membrane
CHR53_RS15950	COG2814	Major facilitator Superfamily
CHR53_RS15955	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS15965	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS15975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR53_RS15985	COG2030	dehydratase
CHR53_RS16000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHR53_RS16020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CHR53_RS16030	COG1266	CAAX protease self-immunity
CHR53_RS16045	COG2353	YceI-like domain
CHR53_RS16065	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS16070	COG0583	DNA-binding transcription factor activity
CHR53_RS16090	COG1418	mRNA catabolic process
CHR53_RS16095	COG4129	membrane
CHR53_RS16115	COG1556	Lactate utilization protein
CHR53_RS16120	COG1139	Iron-sulfur cluster binding protein
CHR53_RS16130	COG0583	DNA-binding transcription factor activity
CHR53_RS16155	COG5566	PFAM Mor transcription activator
CHR53_RS16175	COG0154	amidase activity
CHR53_RS16180	COG1301	dicarboxylic acid transport
CHR53_RS16190	COG2186	Transcriptional regulator
CHR53_RS16200	COG5658	integral membrane protein
CHR53_RS16205	COG0640	Transcriptional regulator
CHR53_RS16215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHR53_RS16235	COG0656	L-ascorbic acid biosynthetic process
CHR53_RS16240	COG2814	Major facilitator Superfamily
CHR53_RS16245	COG1733	regulation of RNA biosynthetic process
CHR53_RS16255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHR53_RS16260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CHR53_RS16275	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CHR53_RS16280	COG0788	formyltetrahydrofolate deformylase activity
CHR53_RS16285	COG2323	membrane
CHR53_RS16310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CHR53_RS16315	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS16355	COG2814	Major facilitator Superfamily
CHR53_RS16360	COG0602	queuosine metabolic process
CHR53_RS16365	COG0720	synthase
CHR53_RS16375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CHR53_RS16395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CHR53_RS16405	COG5609	conserved protein (DUF2294)
CHR53_RS16420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHR53_RS16425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHR53_RS16430	COG1113	amino acid transport
CHR53_RS16440	COG3681	Belongs to the UPF0597 family
CHR53_RS16445	COG0516	GMP reductase activity
CHR53_RS16455	COG5002	protein histidine kinase activity
CHR53_RS16460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CHR53_RS16470	COG3773	Cell wall hydrolase
CHR53_RS16470	COG3409	Peptidoglycan-binding domain 1 protein
CHR53_RS16480	COG1620	l-lactate permease
CHR53_RS16490	COG0385	Bile acid
CHR53_RS16505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHR53_RS16510	COG2022	thiamine diphosphate biosynthetic process
CHR53_RS16520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHR53_RS16525	COG0352	thiamine-phosphate diphosphorylase activity
CHR53_RS16530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHR53_RS16535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS16540	COG1116	anion transmembrane transporter activity
CHR53_RS16545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR53_RS16550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHR53_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS16585	COG1346	cytolysis
CHR53_RS16595	COG0583	DNA-binding transcription factor activity
CHR53_RS16605	COG1114	Component of the transport system for branched-chain amino acids
CHR53_RS16610	COG0531	amino acid
CHR53_RS16615	COG1285	pathogenesis
CHR53_RS16620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CHR53_RS16625	COG1349	DNA-binding transcription factor activity
CHR53_RS16640	COG0395	ABC-type sugar transport system, permease component
CHR53_RS16650	COG4143	(ABC) transporter
CHR53_RS16655	COG0039	L-malate dehydrogenase activity
CHR53_RS16660	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CHR53_RS16665	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CHR53_RS16685	COG1454	alcohol dehydrogenase
CHR53_RS16685	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS16695	COG4302	ethanolamine ammonia-lyase activity
CHR53_RS16700	COG4303	Ethanolamine ammonia lyase large subunit
CHR53_RS16715	COG4810	utilization protein
CHR53_RS16720	COG3192	ethanolamine utilization protein
CHR53_RS16735	COG4302	ethanolamine ammonia-lyase activity
CHR53_RS16740	COG4303	Ethanolamine ammonia lyase large subunit
CHR53_RS16750	COG0701	Predicted permease
CHR53_RS16755	COG2271	Major facilitator Superfamily
CHR53_RS16775	COG0039	L-malate dehydrogenase activity
CHR53_RS16780	COG0686	Belongs to the AlaDH PNT family
CHR53_RS16785	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CHR53_RS16795	COG4869	propanediol catabolic process
CHR53_RS16810	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CHR53_RS16815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHR53_RS16815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CHR53_RS16825	COG1285	pathogenesis
CHR53_RS16830	COG1349	DNA-binding transcription factor activity
CHR53_RS16835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CHR53_RS16835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHR53_RS16840	COG0477	Major facilitator Superfamily
CHR53_RS16855	COG3842	ATPase activity
CHR53_RS16860	COG1840	ABC-type Fe3 transport system, periplasmic component
CHR53_RS16865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHR53_RS16875	COG1011	Hydrolase
CHR53_RS16880	COG0024	Methionine aminopeptidase
CHR53_RS16885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR53_RS16890	COG4521	taurine ABC transporter
CHR53_RS16895	COG1116	anion transmembrane transporter activity
CHR53_RS16905	COG1113	amino acid transport
CHR53_RS16920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CHR53_RS16925	COG0686	Belongs to the AlaDH PNT family
CHR53_RS16930	COG1725	Transcriptional regulator
CHR53_RS16935	COG0583	DNA-binding transcription factor activity
CHR53_RS16945	COG1228	amidohydrolase
CHR53_RS16965	COG3290	protein histidine kinase activity
CHR53_RS16985	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CHR53_RS16990	COG0454	-acetyltransferase
CHR53_RS17005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS17030	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS17050	COG1695	Transcriptional regulator
CHR53_RS17060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CHR53_RS17065	COG1845	cytochrome c oxidase, subunit III
CHR53_RS17070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CHR53_RS17075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CHR53_RS17090	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS17095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHR53_RS17115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CHR53_RS17125	COG1984	allophanate hydrolase subunit 2
CHR53_RS17135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CHR53_RS17185	COG3835	regulator
CHR53_RS17190	COG0733	neurotransmitter:sodium symporter activity
CHR53_RS17205	COG3835	regulator
CHR53_RS17210	COG0028	Belongs to the TPP enzyme family
CHR53_RS17220	COG0436	Aminotransferase
CHR53_RS17230	COG5337	Spore coat protein CotH
CHR53_RS17240	COG0277	FAD linked oxidase domain protein
CHR53_RS17245	COG0247	lactate metabolic process
CHR53_RS17250	COG0277	FAD linked oxidase domain protein
CHR53_RS17260	COG2027	D-alanyl-D-alanine carboxypeptidase
CHR53_RS17265	COG1388	LysM domain
CHR53_RS17265	COG3858	chitin binding
CHR53_RS17285	COG0574	Belongs to the PEP-utilizing enzyme family
CHR53_RS17285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHR53_RS17290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CHR53_RS17295	COG0517	IMP dehydrogenase activity
CHR53_RS17300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CHR53_RS17355	COG0708	Exodeoxyribonuclease III
CHR53_RS17360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHR53_RS17375	COG1657	PFAM Prenyltransferase squalene oxidase
CHR53_RS17385	COG4413	Urea transporter
CHR53_RS17395	COG0829	nickel cation binding
CHR53_RS17400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CHR53_RS17405	COG0830	nickel cation binding
CHR53_RS17410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CHR53_RS17415	COG0804	urea catabolic process
CHR53_RS17425	COG0831	urea catabolic process
CHR53_RS17430	COG3663	DNA glycosylase
CHR53_RS17445	COG1477	protein flavinylation
CHR53_RS17460	COG0745	RESPONSE REGULATOR receiver
CHR53_RS17465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS17475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHR53_RS17480	COG5002	protein histidine kinase activity
CHR53_RS17480	COG3850	Histidine kinase
CHR53_RS17485	COG0745	RESPONSE REGULATOR receiver
CHR53_RS17495	COG2720	vancomycin resistance protein
CHR53_RS17510	COG0726	polysaccharide deacetylase
CHR53_RS17515	COG2226	methyltransferase
CHR53_RS17530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS17550	COG2323	membrane
CHR53_RS17555	COG0697	spore germination
CHR53_RS17560	COG0833	amino acid
CHR53_RS17580	COG0017	Asparaginyl-tRNA synthetase
CHR53_RS17595	COG3973	AAA domain
CHR53_RS17600	COG2353	YceI-like domain
CHR53_RS17605	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS17610	COG1937	Protein conserved in bacteria
CHR53_RS17635	COG0789	Transcriptional regulator
CHR53_RS17640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHR53_RS17645	COG3594	Acyltransferase
CHR53_RS17650	COG2404	hydrolase activity, acting on ester bonds
CHR53_RS17655	COG5002	protein histidine kinase activity
CHR53_RS17655	COG3850	Histidine kinase
CHR53_RS17675	COG0527	aspartate kinase activity
CHR53_RS17685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHR53_RS17690	COG4120	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS17705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CHR53_RS17715	COG1525	nuclease
CHR53_RS17725	COG3344	reverse transcriptase
CHR53_RS17730	COG1368	sulfuric ester hydrolase activity
CHR53_RS17745	COG0569	domain protein
CHR53_RS17750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHR53_RS17755	COG2223	nitrite transmembrane transporter activity
CHR53_RS17760	COG2223	nitrite transmembrane transporter activity
CHR53_RS17765	COG3383	formate dehydrogenase (NAD+) activity
CHR53_RS17770	COG0243	molybdopterin cofactor binding
CHR53_RS17775	COG5002	protein histidine kinase activity
CHR53_RS17805	COG2181	nitrate reductase activity
CHR53_RS17815	COG1140	nitrate reductase beta subunit
CHR53_RS17820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CHR53_RS17840	COG1999	signal sequence binding
CHR53_RS17845	COG0488	(ABC) transporter
CHR53_RS17865	COG0071	Belongs to the small heat shock protein (HSP20) family
CHR53_RS17870	COG1686	Belongs to the peptidase S11 family
CHR53_RS17875	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CHR53_RS17875	COG0392	lysyltransferase activity
CHR53_RS17885	COG0706	membrane insertase activity
CHR53_RS17895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHR53_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS17920	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHR53_RS17925	COG0567	Dehydrogenase, E1 component
CHR53_RS17930	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CHR53_RS17950	COG0134	indole-3-glycerol-phosphate synthase activity
CHR53_RS17960	COG0512	Glutamine amidotransferase of anthranilate synthase
CHR53_RS17960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CHR53_RS17970	COG2814	Major facilitator Superfamily
CHR53_RS18000	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CHR53_RS18005	COG3285	dna ligase
CHR53_RS18005	COG1793	dna ligase
CHR53_RS18010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CHR53_RS18035	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS18075	COG0793	Belongs to the peptidase S41A family
CHR53_RS18075	COG3409	Peptidoglycan-binding domain 1 protein
CHR53_RS18090	COG4326	sporulation control protein
CHR53_RS18105	COG4479	Belongs to the UPF0346 family
CHR53_RS18115	COG1509	lysine 2,3-aminomutase activity
CHR53_RS18120	COG3829	transcription factor binding
CHR53_RS18125	COG0456	acetyltransferase
CHR53_RS18130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS18135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CHR53_RS18140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CHR53_RS18145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CHR53_RS18150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHR53_RS18165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR53_RS18170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR53_RS18190	COG2755	lipolytic protein G-D-S-L family
CHR53_RS18200	COG1999	signal sequence binding
CHR53_RS18205	COG5002	protein histidine kinase activity
CHR53_RS18215	COG1307	EDD domain protein, DegV family
CHR53_RS18230	COG0681	Belongs to the peptidase S26 family
CHR53_RS18245	COG0805	protein transport
CHR53_RS18250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHR53_RS18260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHR53_RS18275	COG2310	stress, protein
CHR53_RS18280	COG2310	stress, protein
CHR53_RS18285	COG3853	Toxic anion resistance protein (TelA)
CHR53_RS18320	COG0861	Integral membrane protein TerC family
CHR53_RS18325	COG2310	stress, protein
CHR53_RS18340	COG1413	lyase activity
CHR53_RS18345	COG0488	(ABC) transporter
CHR53_RS18350	COG1418	mRNA catabolic process
CHR53_RS18355	COG1307	EDD domain protein, DegV family
CHR53_RS18380	COG1321	iron dependent repressor
CHR53_RS18385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHR53_RS18395	COG1278	Cold shock
CHR53_RS18405	COG0328	RNA-DNA hybrid ribonuclease activity
CHR53_RS18420	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CHR53_RS18430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR53_RS18435	COG2897	thiosulfate sulfurtransferase activity
CHR53_RS18440	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CHR53_RS18445	COG1755	Isoprenylcysteine carboxyl methyltransferase
CHR53_RS18450	COG3424	synthase
CHR53_RS18460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CHR53_RS18465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CHR53_RS18475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CHR53_RS18510	COG2151	metal-sulfur cluster biosynthetic enzyme
CHR53_RS18515	COG1199	ATP-dependent helicase activity
CHR53_RS18520	COG0116	Belongs to the methyltransferase superfamily
CHR53_RS18535	COG4474	Belongs to the UPF0398 family
CHR53_RS18545	COG3359	exonuclease
CHR53_RS18550	COG1205	dead DEAH box helicase
CHR53_RS18550	COG1111	helicase
CHR53_RS18555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHR53_RS18590	COG3331	DNA recombination
CHR53_RS18595	COG4499	WXG100 protein secretion system (Wss), protein YukC
CHR53_RS18595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR53_RS18605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHR53_RS18610	COG3935	DnaD domain protein
CHR53_RS18630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHR53_RS18630	COG1199	ATP-dependent helicase activity
CHR53_RS18635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CHR53_RS18640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CHR53_RS18645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CHR53_RS18660	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS18665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CHR53_RS18670	COG1803	Methylglyoxal synthase
CHR53_RS18675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHR53_RS18680	COG1694	Mazg nucleotide pyrophosphohydrolase
CHR53_RS18685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS18690	COG2738	Putative neutral zinc metallopeptidase
CHR53_RS18700	COG4347	Protein of unknown function (DUF1405)
CHR53_RS18710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CHR53_RS18725	COG5582	Belongs to the UPF0302 family
CHR53_RS18730	COG0457	Tetratricopeptide repeat
CHR53_RS18740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHR53_RS18745	COG0287	Prephenate dehydrogenase
CHR53_RS18750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHR53_RS18755	COG4401	Chorismate mutase type I
CHR53_RS18760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHR53_RS18770	COG0105	UTP biosynthetic process
CHR53_RS18780	COG2226	methyltransferase
CHR53_RS18785	COG0142	geranyltranstransferase activity
CHR53_RS18795	COG0302	gtp cyclohydrolase
CHR53_RS18800	COG0776	regulation of translation
CHR53_RS18805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CHR53_RS18820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHR53_RS18825	COG1160	GTP binding
CHR53_RS18840	COG1304	FMN binding
CHR53_RS18845	COG0539	negative regulation of cytoplasmic translation
CHR53_RS18850	COG2937	Belongs to the GPAT DAPAT family
CHR53_RS18855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CHR53_RS18865	COG2959	enzyme of heme biosynthesis
CHR53_RS18890	COG2339	peptidase activity
CHR53_RS18900	COG0492	ferredoxin-NADP+ reductase activity
CHR53_RS18905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHR53_RS18910	COG4862	establishment of competence for transformation
CHR53_RS18915	COG1408	metallophosphoesterase
CHR53_RS18935	COG3546	catalase activity
CHR53_RS18950	COG1266	CAAX protease self-immunity
CHR53_RS18955	COG0514	ATP-dependent DNA helicase (RecQ)
CHR53_RS18960	COG4955	Helix-turn-helix domain
CHR53_RS18970	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CHR53_RS18975	COG3942	CHAP domain
CHR53_RS18975	COG1388	LysM domain
CHR53_RS18985	COG1595	DNA-templated transcription, initiation
CHR53_RS18990	COG5002	protein histidine kinase activity
CHR53_RS18995	COG0745	RESPONSE REGULATOR receiver
CHR53_RS19000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHR53_RS19005	COG1333	cytochrome c biogenesis protein
CHR53_RS19010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS19015	COG1187	pseudouridine synthase activity
CHR53_RS19020	COG0700	Nucleoside recognition
CHR53_RS19025	COG2715	membrane protein required for spore maturation
CHR53_RS19030	COG1686	Belongs to the peptidase S11 family
CHR53_RS19035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CHR53_RS19045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CHR53_RS19060	COG1547	Domain of unknown function (DUF309)
CHR53_RS19070	COG4086	secreted protein
CHR53_RS19080	COG0697	spore germination
CHR53_RS19105	COG2172	sigma factor antagonist activity
CHR53_RS19115	COG1686	Belongs to the peptidase S11 family
CHR53_RS19130	COG4974	Belongs to the 'phage' integrase family
CHR53_RS19140	COG0735	belongs to the Fur family
CHR53_RS19145	COG1300	Membrane
CHR53_RS19150	COG1379	DNA repair
CHR53_RS19165	COG0667	Aldo Keto reductase
CHR53_RS19175	COG0183	Belongs to the thiolase family
CHR53_RS19180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHR53_RS19185	COG1073	alpha beta
CHR53_RS19205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CHR53_RS19220	COG0300	oxidoreductase activity
CHR53_RS19225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS19230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHR53_RS19235	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS19240	COG1902	pentaerythritol trinitrate reductase activity
CHR53_RS19245	COG1234	tRNA 3'-trailer cleavage
CHR53_RS19250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHR53_RS19255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CHR53_RS19260	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHR53_RS19265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHR53_RS19270	COG0346	lactoylglutathione lyase activity
CHR53_RS19275	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS19280	COG1126	abc transporter atp-binding protein
CHR53_RS19285	COG0765	amino acid transport
CHR53_RS19290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS19310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CHR53_RS19310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CHR53_RS19315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CHR53_RS19320	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHR53_RS19325	COG0022	dehydrogenase e1 component
CHR53_RS19330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHR53_RS19335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHR53_RS19340	COG3426	butyrate kinase activity
CHR53_RS19350	COG0280	phosphate acetyltransferase
CHR53_RS19355	COG3829	transcription factor binding
CHR53_RS19355	COG3290	protein histidine kinase activity
CHR53_RS19365	COG0584	glycerophosphoryl diester phosphodiesterase
CHR53_RS19375	COG0750	zinc metalloprotease
CHR53_RS19380	COG0497	DNA recombination
CHR53_RS19385	COG1438	arginine binding
CHR53_RS19390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CHR53_RS19395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CHR53_RS19405	COG1722	exodeoxyribonuclease VII activity
CHR53_RS19410	COG1570	exodeoxyribonuclease VII activity
CHR53_RS19415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHR53_RS19420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHR53_RS19425	COG1302	Protein conserved in bacteria
CHR53_RS19430	COG0439	Biotin carboxylase
CHR53_RS19435	COG0511	ligase activity, forming carbon-carbon bonds
CHR53_RS19475	COG3854	ATPases associated with a variety of cellular activities
CHR53_RS19485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS19495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHR53_RS19505	COG4555	ABC transporter
CHR53_RS19525	COG1138	Cytochrome C-type biogenesis protein
CHR53_RS19530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CHR53_RS19540	COG2010	Cytochrome c
CHR53_RS19555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHR53_RS19560	COG0006	proline dipeptidase activity
CHR53_RS19570	COG3872	metal-dependent enzyme
CHR53_RS19580	COG1752	Esterase of the alpha-beta hydrolase superfamily
CHR53_RS19585	COG2217	Heavy metal translocating P-type atpase
CHR53_RS19590	COG2608	mercury ion transmembrane transporter activity
CHR53_RS19605	COG0791	NLP P60 protein
CHR53_RS19605	COG1388	LysM domain
CHR53_RS19610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHR53_RS19615	COG0095	Lipoate-protein ligase
CHR53_RS19620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS19625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS19630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHR53_RS19635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CHR53_RS19640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHR53_RS19660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS19700	COG4970	Tfp pilus assembly protein FimT
CHR53_RS19705	COG4537	Required for transformation and DNA binding
CHR53_RS19710	COG1459	type II secretion system
CHR53_RS19715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHR53_RS19720	COG1940	carbohydrate kinase activity
CHR53_RS19735	COG0705	Rhomboid family
CHR53_RS19735	COG0457	Tetratricopeptide repeat
CHR53_RS19755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHR53_RS19780	COG0704	Plays a role in the regulation of phosphate uptake
CHR53_RS19785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHR53_RS19790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHR53_RS19795	COG0581	inorganic phosphate transmembrane transporter activity
CHR53_RS19800	COG0573	inorganic phosphate transmembrane transporter activity
CHR53_RS19805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CHR53_RS19810	COG0768	penicillin binding
CHR53_RS19815	COG0477	Major facilitator Superfamily
CHR53_RS19825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHR53_RS19830	COG5521	maltodextrose utilization protein MalA
CHR53_RS19840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHR53_RS19845	COG4709	membrane
CHR53_RS19850	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CHR53_RS19855	COG0735	belongs to the Fur family
CHR53_RS19860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHR53_RS19865	COG1121	(ABC) transporter
CHR53_RS19875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CHR53_RS19885	COG0513	Belongs to the DEAD box helicase family
CHR53_RS19890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CHR53_RS19895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHR53_RS19900	COG2384	SAM-dependent methyltransferase
CHR53_RS19905	COG2010	Cytochrome c
CHR53_RS19910	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS19915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHR53_RS19920	COG0358	DNA primase activity
CHR53_RS19930	COG0517	IMP dehydrogenase activity
CHR53_RS19935	COG0423	glycine-tRNA ligase activity
CHR53_RS19940	COG1381	Involved in DNA repair and RecF pathway recombination
CHR53_RS19950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CHR53_RS19955	COG0295	cytidine deaminase activity
CHR53_RS19960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CHR53_RS19970	COG1480	7TM receptor with intracellular HD hydrolase
CHR53_RS19975	COG1702	phosphate starvation-inducible protein PhoH
CHR53_RS19995	COG4864	UPF0365 protein
CHR53_RS20000	COG1030	water channel activity
CHR53_RS20005	COG1610	YqeY-like protein
CHR53_RS20015	COG1283	sodium-dependent phosphate transmembrane transporter activity
CHR53_RS20020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHR53_RS20025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CHR53_RS20030	COG2264	protein methyltransferase activity
CHR53_RS20035	COG0484	heat shock protein binding
CHR53_RS20040	COG0443	Heat shock 70 kDa protein
CHR53_RS20045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CHR53_RS20050	COG1420	regulation of RNA biosynthetic process
CHR53_RS20055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHR53_RS20060	COG0481	GTPase activity
CHR53_RS20070	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHR53_RS20080	COG0268	Binds directly to 16S ribosomal RNA
CHR53_RS20085	COG1466	dna polymerase III delta subunit
CHR53_RS20095	COG0658	competence protein
CHR53_RS20095	COG2333	competence protein COMEC
CHR53_RS20100	COG2131	deaminase
CHR53_RS20105	COG1555	photosystem II stabilization
CHR53_RS20105	COG1596	polysaccharide export
CHR53_RS20110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHR53_RS20115	COG2226	methyltransferase
CHR53_RS20120	COG0799	negative regulation of ribosome biogenesis
CHR53_RS20125	COG1713	HD superfamily hydrolase involved in NAD metabolism
CHR53_RS20130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CHR53_RS20135	COG1534	Rna-binding protein
CHR53_RS20145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHR53_RS20150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CHR53_RS20160	COG0688	phosphatidylethanolamine metabolic process
CHR53_RS20165	COG1183	phosphatidylcholine synthase activity
CHR53_RS20200	COG1024	Enoyl-CoA hydratase
CHR53_RS20205	COG0183	Belongs to the thiolase family
CHR53_RS20210	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHR53_RS20215	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS20220	COG1024	Enoyl-CoA hydratase
CHR53_RS20225	COG1024	Enoyl-CoA hydratase
CHR53_RS20250	COG3396	Phenylacetate-CoA oxygenase
CHR53_RS20255	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CHR53_RS20280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHR53_RS20290	COG4946	Tricorn protease homolog
CHR53_RS20290	COG0823	Involved in the tonB-independent uptake of proteins
CHR53_RS20290	COG1506	peptidase
CHR53_RS20295	COG0768	penicillin binding
CHR53_RS20300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHR53_RS20305	COG0572	uridine kinase
CHR53_RS20310	COG0826	peptidase U32
CHR53_RS20315	COG0826	peptidase U32
CHR53_RS20320	COG4122	O-methyltransferase activity
CHR53_RS20325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHR53_RS20330	COG3906	Belongs to the UPF0473 family
CHR53_RS20335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHR53_RS20340	COG4472	Bacterial protein of unknown function (DUF965)
CHR53_RS20345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CHR53_RS20350	COG0628	permease
CHR53_RS20370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHR53_RS20380	COG1113	amino acid transport
CHR53_RS20385	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHR53_RS20405	COG1522	sequence-specific DNA binding
CHR53_RS20415	COG1104	cysteine desulfurase activity
CHR53_RS20420	COG1959	2 iron, 2 sulfur cluster binding
CHR53_RS20425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHR53_RS20430	COG1054	Belongs to the UPF0176 family
CHR53_RS20435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CHR53_RS20440	COG1131	(ABC) transporter
CHR53_RS20450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CHR53_RS20460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHR53_RS20465	COG0124	histidyl-tRNA synthetase
CHR53_RS20470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHR53_RS20470	COG4991	sh3 domain protein
CHR53_RS20470	COG3103	Sh3 type 3 domain protein
CHR53_RS20475	COG1490	D-aminoacyl-tRNA deacylase activity
CHR53_RS20480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHR53_RS20485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHR53_RS20490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHR53_RS20490	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CHR53_RS20495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHR53_RS20495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHR53_RS20505	COG2244	polysaccharide biosynthetic process
CHR53_RS20510	COG2323	membrane
CHR53_RS20520	COG1862	Preprotein translocase
CHR53_RS20540	COG2255	four-way junction helicase activity
CHR53_RS20545	COG0632	four-way junction helicase activity
CHR53_RS20575	COG1827	regulation of RNA biosynthetic process
CHR53_RS20580	COG0077	Prephenate dehydratase
CHR53_RS20585	COG4492	Belongs to the UPF0735 family
CHR53_RS20590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CHR53_RS20595	COG3290	protein histidine kinase activity
CHR53_RS20600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHR53_RS20605	COG2868	ribosomal protein
CHR53_RS20615	COG1530	ribonuclease E activity
CHR53_RS20620	COG1994	Peptidase M50
CHR53_RS20630	COG2894	cell division
CHR53_RS20635	COG0850	regulation of cytokinetic process
CHR53_RS20645	COG1792	Involved in formation and maintenance of cell shape
CHR53_RS20650	COG1077	Cell shape determining protein MreB Mrl
CHR53_RS20655	COG2003	Belongs to the UPF0758 family
CHR53_RS20685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CHR53_RS20695	COG1459	type II secretion system
CHR53_RS20705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHR53_RS20735	COG3706	GGDEF domain
CHR53_RS20740	COG0285	dihydrofolate synthase activity
CHR53_RS20745	COG0525	valine-tRNA ligase activity
CHR53_RS20765	COG1388	LysM domain
CHR53_RS20770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CHR53_RS20775	COG0113	porphobilinogen synthase activity
CHR53_RS20785	COG0181	hydroxymethylbilane synthase activity
CHR53_RS20790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHR53_RS20810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CHR53_RS20815	COG1067	ATP-dependent peptidase activity
CHR53_RS20815	COG0470	DNA polymerase III
CHR53_RS20825	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHR53_RS20830	COG1477	protein flavinylation
CHR53_RS20830	COG0457	Tetratricopeptide repeat
CHR53_RS20840	COG0622	Phosphoesterase
CHR53_RS20845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHR53_RS20855	COG5401	PFAM Sporulation and spore germination
CHR53_RS20860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CHR53_RS20865	COG1846	Transcriptional regulator
CHR53_RS20870	COG2197	response regulator
CHR53_RS20875	COG1523	belongs to the glycosyl hydrolase 13 family
CHR53_RS20880	COG3764	Sortase (surface protein transpeptidase)
CHR53_RS20885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CHR53_RS20890	COG1053	succinate dehydrogenase
CHR53_RS20895	COG2009	succinate dehydrogenase
CHR53_RS20900	COG1719	4-vinyl reductase, 4VR
CHR53_RS20910	COG0322	excinuclease ABC activity
CHR53_RS20915	COG3118	belongs to the thioredoxin family
CHR53_RS20920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CHR53_RS20925	COG2086	electron transfer activity
CHR53_RS20930	COG1024	Enoyl-CoA hydratase
CHR53_RS20935	COG1309	transcriptional regulator
CHR53_RS20940	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS20945	COG3766	membrane
CHR53_RS20950	COG1193	negative regulation of DNA recombination
CHR53_RS20955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CHR53_RS20955	COG1796	DNA polymerase
CHR53_RS20960	COG1286	toxin biosynthetic process
CHR53_RS20965	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CHR53_RS20970	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHR53_RS20975	COG2154	pterin-4-alpha-carbinolamine dehydratase
CHR53_RS20985	COG0072	phenylalanine-tRNA ligase activity
CHR53_RS20985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHR53_RS20990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CHR53_RS20995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHR53_RS21015	COG2207	Transcriptional regulator
CHR53_RS21015	COG1609	Transcriptional regulator
CHR53_RS21020	COG1363	Peptidase, m42
CHR53_RS21025	COG0589	response to stress
CHR53_RS21040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CHR53_RS21045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHR53_RS21050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CHR53_RS21055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHR53_RS21065	COG1484	DNA-dependent DNA replication
CHR53_RS21070	COG3611	Membrane attachment protein
CHR53_RS21075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHR53_RS21085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CHR53_RS21095	COG1971	Probably functions as a manganese efflux pump
CHR53_RS21100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CHR53_RS21105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR53_RS21105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR53_RS21110	COG5002	protein histidine kinase activity
CHR53_RS21115	COG0745	RESPONSE REGULATOR receiver
CHR53_RS21125	COG0039	L-malate dehydrogenase activity
CHR53_RS21130	COG0538	isocitrate dehydrogenase activity
CHR53_RS21135	COG0372	Belongs to the citrate synthase family
CHR53_RS21140	COG0628	permease
CHR53_RS21155	COG0825	malonyl-CoA metabolic process
CHR53_RS21160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CHR53_RS21165	COG2186	Transcriptional regulator
CHR53_RS21170	COG0281	malic enzyme
CHR53_RS21175	COG0587	DNA-directed DNA polymerase activity
CHR53_RS21190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CHR53_RS21200	COG4109	DRTGG domain
CHR53_RS21210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CHR53_RS21215	COG0006	proline dipeptidase activity
CHR53_RS21230	COG0589	response to stress
CHR53_RS21250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CHR53_RS21255	COG0827	DNA restriction-modification system
CHR53_RS21260	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CHR53_RS21265	COG3874	Sporulation protein YtfJ
CHR53_RS21275	COG1714	RDD family
CHR53_RS21280	COG0616	signal peptide processing
CHR53_RS21285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHR53_RS21290	COG2962	Rard protein
CHR53_RS21295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHR53_RS21305	COG0301	tRNA thio-modification
CHR53_RS21310	COG1104	cysteine desulfurase activity
CHR53_RS21315	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CHR53_RS21320	COG1309	transcriptional regulator
CHR53_RS21325	COG1956	GAF domain-containing protein
CHR53_RS21330	COG0626	cystathionine gamma-synthase activity
CHR53_RS21335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHR53_RS21345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHR53_RS21350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHR53_RS21355	COG0454	-acetyltransferase
CHR53_RS21360	COG0517	IMP dehydrogenase activity
CHR53_RS21365	COG0123	including yeast histone deacetylase and acetoin utilization protein
CHR53_RS21375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CHR53_RS21375	COG1605	Chorismate mutase
CHR53_RS21380	COG3118	belongs to the thioredoxin family
CHR53_RS21385	COG4980	gas vesicle protein
CHR53_RS21390	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CHR53_RS21395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHR53_RS21400	COG1674	ftsk spoiiie
CHR53_RS21405	COG4848	Belongs to the UPF0354 family
CHR53_RS21410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS21415	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CHR53_RS21420	COG1363	Peptidase, m42
CHR53_RS21430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS21435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHR53_RS21445	COG0510	thiamine kinase activity
CHR53_RS21450	COG1523	belongs to the glycosyl hydrolase 13 family
CHR53_RS21465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS21470	COG1349	DNA-binding transcription factor activity
CHR53_RS21475	COG1113	amino acid transport
CHR53_RS21490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHR53_RS21495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CHR53_RS21510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHR53_RS21515	COG1187	pseudouridine synthase activity
CHR53_RS21520	COG2244	polysaccharide biosynthetic process
CHR53_RS21525	COG2081	HI0933 family
CHR53_RS21540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHR53_RS21545	COG0495	leucyl-tRNA aminoacylation
CHR53_RS21550	COG2814	Major facilitator Superfamily
CHR53_RS21555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CHR53_RS21575	COG1242	4 iron, 4 sulfur cluster binding
CHR53_RS21580	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CHR53_RS21590	COG2267	carboxylic ester hydrolase activity
CHR53_RS21595	COG0367	asparagine synthase
CHR53_RS21600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHR53_RS21615	COG1506	peptidase
CHR53_RS21620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CHR53_RS21625	COG1116	anion transmembrane transporter activity
CHR53_RS21630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR53_RS21655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CHR53_RS21660	COG0288	reversible hydration of carbon dioxide
CHR53_RS21675	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS21680	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS21685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CHR53_RS21690	COG0596	Alpha beta hydrolase
CHR53_RS21700	COG1169	isochorismate synthase
CHR53_RS21705	COG1575	Belongs to the MenA family. Type 1 subfamily
CHR53_RS21710	COG0058	SHG alpha-glucan phosphorylase activity
CHR53_RS21715	COG0297	glycogen (starch) synthase activity
CHR53_RS21720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHR53_RS21855	COG1285	pathogenesis
CHR53_RS21875	COG1115	amino acid carrier protein
CHR53_RS21880	COG3938	Belongs to the proline racemase family
CHR53_RS21885	COG3938	Belongs to the proline racemase family
CHR53_RS21890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHR53_RS21895	COG3290	protein histidine kinase activity
CHR53_RS21895	COG3829	transcription factor binding
CHR53_RS21925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHR53_RS21940	COG0425	Belongs to the sulfur carrier protein TusA family
CHR53_RS21945	COG0583	DNA-binding transcription factor activity
CHR53_RS21955	COG5577	PFAM Coat F domain
CHR53_RS21970	COG5577	PFAM Coat F domain
CHR53_RS21975	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS21995	COG0083	homoserine kinase activity
CHR53_RS22000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CHR53_RS22005	COG0460	homoserine dehydrogenase
CHR53_RS22010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHR53_RS22025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHR53_RS22035	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS22040	COG3829	transcription factor binding
CHR53_RS22055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHR53_RS22060	COG0531	amino acid
CHR53_RS22065	COG0531	amino acid
CHR53_RS22070	COG3773	Cell wall hydrolase
CHR53_RS22075	COG0783	Belongs to the Dps family
CHR53_RS22080	COG0492	ferredoxin-NADP+ reductase activity
CHR53_RS22085	COG2233	PERMEase
CHR53_RS22090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CHR53_RS22095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHR53_RS22110	COG1349	DNA-binding transcription factor activity
CHR53_RS22115	COG3347	Dehydrogenase
CHR53_RS22115	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS22120	COG1069	ribulokinase activity
CHR53_RS22130	COG1070	Carbohydrate kinase
CHR53_RS22135	COG0235	Class ii aldolase
CHR53_RS22140	COG4221	oxidoreductase activity
CHR53_RS22150	COG1172	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS22155	COG1129	ABC transporter
CHR53_RS22160	COG1349	DNA-binding transcription factor activity
CHR53_RS22165	COG4154	Belongs to the RbsD FucU family
CHR53_RS22170	COG1070	Carbohydrate kinase
CHR53_RS22175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CHR53_RS22185	COG2706	6-phosphogluconolactonase activity
CHR53_RS22190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHR53_RS22195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CHR53_RS22210	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS22215	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS22220	COG0728	peptidoglycan biosynthetic process
CHR53_RS22235	COG0489	protein tyrosine kinase activity
CHR53_RS22240	COG3944	biosynthesis protein
CHR53_RS22250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CHR53_RS22255	COG1086	Polysaccharide biosynthesis protein
CHR53_RS22260	COG0626	cystathionine gamma-synthase activity
CHR53_RS22265	COG0626	cystathionine gamma-synthase activity
CHR53_RS22270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CHR53_RS22270	COG0646	methionine synthase
CHR53_RS22275	COG0646	methionine synthase
CHR53_RS22275	COG1410	methionine synthase
CHR53_RS22285	COG2814	Major facilitator Superfamily
CHR53_RS22295	COG1984	allophanate hydrolase subunit 2
CHR53_RS22300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CHR53_RS22305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CHR53_RS22315	COG2814	Major facilitator Superfamily
CHR53_RS22340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CHR53_RS22350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CHR53_RS22355	COG1113	amino acid transport
CHR53_RS22360	COG1280	lysine exporter protein (LysE YggA)
CHR53_RS22370	COG0463	Glycosyl transferase, family 2
CHR53_RS22380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHR53_RS22395	COG1979	alcohol dehydrogenase
CHR53_RS22400	COG2155	Conserved Protein
CHR53_RS22405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHR53_RS22410	COG1098	S1 RNA binding domain
CHR53_RS22415	COG3620	sequence-specific DNA binding
CHR53_RS22425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CHR53_RS22435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHR53_RS22450	COG2032	superoxide dismutase activity
CHR53_RS22460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHR53_RS22470	COG5018	Exonuclease
CHR53_RS22475	COG2050	protein possibly involved in aromatic compounds catabolism
CHR53_RS22485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHR53_RS22495	COG3584	3D domain protein
CHR53_RS22505	COG1252	NADH dehydrogenase
CHR53_RS22510	COG0492	ferredoxin-NADP+ reductase activity
CHR53_RS22515	COG0316	Belongs to the HesB IscA family
CHR53_RS22525	COG1252	NADH dehydrogenase
CHR53_RS22530	COG4837	Protein of unknown function (DUF1462)
CHR53_RS22535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CHR53_RS22540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHR53_RS22545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CHR53_RS22550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CHR53_RS22555	COG0647	UMP catabolic process
CHR53_RS22560	COG2445	Protein of unknown function DUF86
CHR53_RS22565	COG5001	Diguanylate cyclase
CHR53_RS22565	COG3300	MHYT domain
CHR53_RS22580	COG4470	Protein conserved in bacteria
CHR53_RS22590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CHR53_RS22595	COG0739	heme binding
CHR53_RS22605	COG3377	Domain of unknown function (DUF1805)
CHR53_RS22610	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS22615	COG0730	response to heat
CHR53_RS22620	COG1801	Protein of unknown function DUF72
CHR53_RS22625	COG0719	Fe-S assembly protein
CHR53_RS22630	COG0822	iron-sulfur transferase activity
CHR53_RS22635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHR53_RS22640	COG0719	Fe-S assembly protein
CHR53_RS22645	COG0396	ATPase activity
CHR53_RS22650	COG1464	Belongs to the NlpA lipoprotein family
CHR53_RS22655	COG2011	ABC-type metal ion transport system permease component
CHR53_RS22660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHR53_RS22665	COG2873	o-acetylhomoserine
CHR53_RS22675	COG2271	Major facilitator Superfamily
CHR53_RS22685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHR53_RS22690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CHR53_RS22695	COG0509	glycine decarboxylation via glycine cleavage system
CHR53_RS22700	COG1393	Belongs to the ArsC family
CHR53_RS22705	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS22710	COG0183	Belongs to the thiolase family
CHR53_RS22715	COG1024	Enoyl-CoA hydratase
CHR53_RS22715	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHR53_RS22730	COG1115	amino acid carrier protein
CHR53_RS22735	COG0772	Belongs to the SEDS family
CHR53_RS22750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CHR53_RS22755	COG1910	domain protein
CHR53_RS22775	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS22780	COG2205	protein histidine kinase activity
CHR53_RS22785	COG0745	RESPONSE REGULATOR receiver
CHR53_RS22790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS22795	COG0697	spore germination
CHR53_RS22800	COG2268	Band 7 protein
CHR53_RS22805	COG1585	Membrane protein implicated in regulation of membrane protease activity
CHR53_RS22810	COG1126	abc transporter atp-binding protein
CHR53_RS22815	COG0765	amino acid transport
CHR53_RS22820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR53_RS22835	COG1607	acyl-coa hydrolase
CHR53_RS22855	COG0628	permease
CHR53_RS22860	COG0726	polysaccharide deacetylase
CHR53_RS22935	COG5577	PFAM Coat F domain
CHR53_RS22955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHR53_RS22965	COG2323	membrane
CHR53_RS22985	COG0557	exoribonuclease II activity
CHR53_RS22990	COG1647	Serine aminopeptidase, S33
CHR53_RS22995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CHR53_RS23005	COG0148	phosphopyruvate hydratase activity
CHR53_RS23010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CHR53_RS23020	COG0126	phosphoglycerate kinase activity
CHR53_RS23030	COG2390	Transcriptional regulator
CHR53_RS23040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CHR53_RS23055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHR53_RS23060	COG1481	regulation of sporulation
CHR53_RS23065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CHR53_RS23070	COG1660	Displays ATPase and GTPase activities
CHR53_RS23075	COG1051	belongs to the nudix hydrolase family
CHR53_RS23080	COG0492	ferredoxin-NADP+ reductase activity
CHR53_RS23085	COG0457	Tetratricopeptide repeat
CHR53_RS23090	COG0140	phosphoribosyl-ATP diphosphatase activity
CHR53_RS23090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CHR53_RS23095	COG0107	imidazoleglycerol-phosphate synthase activity
CHR53_RS23100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CHR53_RS23105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CHR53_RS23110	COG0131	Imidazoleglycerol-phosphate dehydratase
CHR53_RS23115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CHR53_RS23120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CHR53_RS23125	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CHR53_RS23135	COG0110	maltose O-acetyltransferase activity
CHR53_RS23145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CHR53_RS23155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CHR53_RS23160	COG1950	PFAM Membrane protein of
CHR53_RS23165	COG3595	metallopeptidase activity
CHR53_RS23175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHR53_RS23180	COG0556	nucleotide-excision repair
CHR53_RS23185	COG4897	Protein conserved in bacteria
CHR53_RS23190	COG4145	pantothenate transmembrane transporter activity
CHR53_RS23195	COG3924	membrane
CHR53_RS23215	COG3361	conserved protein (COG2071)
CHR53_RS23225	COG1294	oxidase, subunit
CHR53_RS23230	COG1271	oxidase subunit
CHR53_RS23265	COG1309	transcriptional regulator
CHR53_RS23270	COG3291	Pkd domain containing protein
CHR53_RS23270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CHR53_RS23275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHR53_RS23280	COG0793	Belongs to the peptidase S41A family
CHR53_RS23280	COG3409	Peptidoglycan-binding domain 1 protein
CHR53_RS23285	COG3883	PFAM NLP P60 protein
CHR53_RS23285	COG0791	NLP P60 protein
CHR53_RS23290	COG2177	Part of the ABC transporter FtsEX involved in
CHR53_RS23295	COG2884	Cell division ATP-binding protein ftsE
CHR53_RS23305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS23345	COG0653	protein targeting
CHR53_RS23360	COG5577	PFAM Coat F domain
CHR53_RS23365	COG1040	competence protein
CHR53_RS23370	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CHR53_RS23385	COG1307	EDD domain protein, DegV family
CHR53_RS23390	COG2197	response regulator
CHR53_RS23395	COG4585	Histidine kinase
CHR53_RS23400	COG1739	Uncharacterized protein family UPF0029
CHR53_RS23405	COG1316	TRANSCRIPTIONal
CHR53_RS23415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHR53_RS23420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CHR53_RS23425	COG1134	teichoic acid transport
CHR53_RS23430	COG1682	transport, permease protein
CHR53_RS23435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHR53_RS23440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CHR53_RS23455	COG4193	domain, Protein
CHR53_RS23460	COG0562	UDP-galactopyranose mutase
CHR53_RS23465	COG0463	Glycosyl transferase, family 2
CHR53_RS23480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHR53_RS23485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHR53_RS23490	COG0463	Glycosyl transferase, family 2
CHR53_RS23490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHR53_RS23500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHR53_RS23500	COG0463	Glycosyl transferase, family 2
CHR53_RS23520	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS23525	COG1316	TRANSCRIPTIONal
CHR53_RS23530	COG1404	Belongs to the peptidase S8 family
CHR53_RS23535	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS23540	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS23555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CHR53_RS23565	COG1876	peptidase activity
CHR53_RS23570	COG3853	Toxic anion resistance protein (TelA)
CHR53_RS23575	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CHR53_RS23585	COG0346	lactoylglutathione lyase activity
CHR53_RS23590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CHR53_RS23620	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CHR53_RS23630	COG0028	Belongs to the TPP enzyme family
CHR53_RS23640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS23645	COG1510	regulation of RNA biosynthetic process
CHR53_RS23650	COG4175	Glycine betaine
CHR53_RS23650	COG0517	IMP dehydrogenase activity
CHR53_RS23655	COG4176	ABC-type proline glycine betaine transport system permease component
CHR53_RS23660	COG2113	Glycine betaine
CHR53_RS23665	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS23680	COG1388	LysM domain
CHR53_RS23680	COG3584	3D domain protein
CHR53_RS23685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CHR53_RS23705	COG2252	PERMEase
CHR53_RS23720	COG0604	alcohol dehydrogenase
CHR53_RS23755	COG0697	spore germination
CHR53_RS23760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHR53_RS23790	COG3142	Participates in the control of copper homeostasis
CHR53_RS23815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR53_RS23815	COG1263	PTS System
CHR53_RS23820	COG1737	Transcriptional regulator
CHR53_RS23830	COG0561	phosphatase activity
CHR53_RS23835	COG3835	regulator
CHR53_RS23840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHR53_RS23845	COG0277	FAD linked oxidase domain protein
CHR53_RS23850	COG0247	lactate metabolic process
CHR53_RS23860	COG1737	Transcriptional regulator
CHR53_RS23865	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CHR53_RS23885	COG0737	Belongs to the 5'-nucleotidase family
CHR53_RS23890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CHR53_RS23895	COG2514	catechol 2,3-dioxygenase activity
CHR53_RS23900	COG2188	Transcriptional regulator
CHR53_RS23905	COG3684	Belongs to the aldolase LacD family
CHR53_RS23920	COG2222	sugar isomerase
CHR53_RS23925	COG1940	carbohydrate kinase activity
CHR53_RS23930	COG0395	ABC-type sugar transport system, permease component
CHR53_RS23935	COG1175	transmembrane transport
CHR53_RS23950	COG1609	Transcriptional regulator
CHR53_RS23965	COG1472	Belongs to the glycosyl hydrolase 3 family
CHR53_RS23970	COG3876	Protein conserved in bacteria
CHR53_RS23980	COG1404	Belongs to the peptidase S8 family
CHR53_RS24110	COG4720	Psort location CytoplasmicMembrane, score
CHR53_RS24120	COG2002	toxin-antitoxin pair type II binding
CHR53_RS24125	COG0069	glutamate synthase activity
CHR53_RS24130	COG0069	glutamate synthase activity
CHR53_RS24135	COG1733	regulation of RNA biosynthetic process
CHR53_RS24140	COG1063	alcohol dehydrogenase
CHR53_RS24150	COG2271	Major facilitator Superfamily
CHR53_RS24155	COG0277	FAD linked oxidase domain protein
CHR53_RS24165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CHR53_RS24170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHR53_RS24175	COG1215	transferase activity, transferring glycosyl groups
CHR53_RS24180	COG1136	(ABC) transporter
CHR53_RS24190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHR53_RS24205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHR53_RS24210	COG1309	transcriptional regulator
CHR53_RS24225	COG0531	amino acid
CHR53_RS24230	COG0697	spore germination
CHR53_RS24240	COG3361	conserved protein (COG2071)
CHR53_RS24245	COG0366	Alpha amylase catalytic
CHR53_RS24250	COG0395	ABC-type sugar transport system, permease component
CHR53_RS24255	COG1175	transmembrane transport
CHR53_RS24270	COG1501	Belongs to the glycosyl hydrolase 31 family
CHR53_RS24275	COG5426	von Willebrand factor, type A
CHR53_RS24280	COG0395	ABC-type sugar transport system, permease component
CHR53_RS24285	COG1175	transmembrane transport
CHR53_RS24315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHR53_RS24315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS24320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS24325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS24330	COG2186	Transcriptional regulator
CHR53_RS24335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CHR53_RS24350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHR53_RS24355	COG0584	glycerophosphoryl diester phosphodiesterase
CHR53_RS24360	COG0583	DNA-binding transcription factor activity
CHR53_RS24365	COG1607	acyl-coa hydrolase
CHR53_RS24415	COG0318	PFAM AMP-dependent synthetase and ligase
CHR53_RS24425	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS24430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHR53_RS24430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS24440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS24445	COG1414	Transcriptional regulator
CHR53_RS24465	COG1191	sigma factor activity
CHR53_RS24470	COG0455	bacterial-type flagellum organization
CHR53_RS24475	COG1419	protein localization to endoplasmic reticulum
CHR53_RS24480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CHR53_RS24485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CHR53_RS24490	COG1684	flagellar biosynthetic protein fliR
CHR53_RS24495	COG1987	bacterial-type flagellum assembly
CHR53_RS24500	COG1338	Plays a role in the flagellum-specific transport system
CHR53_RS24505	COG3190	flagellar
CHR53_RS24510	COG1776	CheC inhibitor of MCP methylation
CHR53_RS24510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHR53_RS24520	COG1157	protein secretion by the type III secretion system
CHR53_RS24530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHR53_RS24535	COG1766	The M ring may be actively involved in energy transduction
CHR53_RS24540	COG1677	Flagellar hook-basal body complex protein FliE
CHR53_RS24545	COG1558	bacterial-type flagellum-dependent cell motility
CHR53_RS24550	COG1815	bacterial-type flagellum-dependent cell motility
CHR53_RS24555	COG1516	flagellar protein fliS
CHR53_RS24565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHR53_RS24565	COG1776	CheC inhibitor of MCP methylation
CHR53_RS24570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHR53_RS24575	COG4786	Flagellar basal body rod
CHR53_RS24580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CHR53_RS24595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CHR53_RS24615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CHR53_RS24640	COG4786	Flagellar basal body rod
CHR53_RS24645	COG4786	Flagellar basal body rod
CHR53_RS24650	COG1728	Protein conserved in bacteria
CHR53_RS24655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CHR53_RS24660	COG1360	Flagellar Motor Protein
CHR53_RS24670	COG2084	Dehydrogenase
CHR53_RS24675	COG3622	Belongs to the hyi family
CHR53_RS24680	COG0683	leucine binding
CHR53_RS24705	COG0753	catalase activity
CHR53_RS24710	COG0011	TIGRFAM Protein of
CHR53_RS24735	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS24740	COG2610	gluconate transmembrane transporter activity
CHR53_RS24745	COG3290	protein histidine kinase activity
CHR53_RS24745	COG3829	transcription factor binding
CHR53_RS24775	COG2197	response regulator
CHR53_RS24780	COG0657	acetylesterase activity
CHR53_RS24785	COG2072	flavoprotein involved in K transport
CHR53_RS24805	COG1695	Transcriptional regulator
CHR53_RS24815	COG0829	nickel cation binding
CHR53_RS24820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CHR53_RS24825	COG0830	nickel cation binding
CHR53_RS24830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CHR53_RS24835	COG0804	urea catabolic process
CHR53_RS24840	COG0832	Belongs to the urease beta subunit family
CHR53_RS24850	COG4413	Urea transporter
CHR53_RS24855	COG5522	Integral membrane protein (intg_mem_TP0381)
CHR53_RS24860	COG3153	acetyltransferase
CHR53_RS24860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHR53_RS24870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CHR53_RS24875	COG0477	Major facilitator Superfamily
CHR53_RS24890	COG2211	Major facilitator Superfamily
CHR53_RS24895	COG0583	DNA-binding transcription factor activity
CHR53_RS24905	COG0786	glutamate:sodium symporter activity
CHR53_RS24915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CHR53_RS24920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHR53_RS24935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHR53_RS24945	COG0784	Response regulator, receiver
CHR53_RS24950	COG4191	Histidine kinase
CHR53_RS24960	COG5002	protein histidine kinase activity
CHR53_RS24970	COG2321	neutral zinc metallopeptidase
CHR53_RS24980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHR53_RS24985	COG0295	cytidine deaminase activity
CHR53_RS24990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CHR53_RS25005	COG0813	purine-nucleoside phosphorylase activity
CHR53_RS25010	COG2814	Major facilitator Superfamily
CHR53_RS25020	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHR53_RS25035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CHR53_RS25040	COG3483	tryptophan 2,3-dioxygenase activity
CHR53_RS25045	COG1113	amino acid transport
CHR53_RS25050	COG3844	kynureninase activity
CHR53_RS25060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR53_RS25065	COG1301	dicarboxylic acid transport
CHR53_RS25070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHR53_RS25090	COG0584	glycerophosphoryl diester phosphodiesterase
CHR53_RS25100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHR53_RS25125	COG2860	membrane
CHR53_RS25130	COG0484	heat shock protein binding
CHR53_RS25145	COG1988	membrane-bound metal-dependent
CHR53_RS25150	COG2824	Alkylphosphonate utilization operon protein PhnA
CHR53_RS25165	COG0450	alkyl hydroperoxide reductase
CHR53_RS25170	COG0450	alkyl hydroperoxide reductase
CHR53_RS25175	COG0667	Aldo Keto reductase
CHR53_RS25185	COG0628	permease
CHR53_RS25190	COG1309	transcriptional regulator
CHR53_RS25195	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS25205	COG0477	Major facilitator Superfamily
CHR53_RS25225	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS25230	COG2318	DinB family
CHR53_RS25255	COG1132	(ABC) transporter
CHR53_RS25260	COG1132	(ABC) transporter
CHR53_RS25265	COG1940	carbohydrate kinase activity
CHR53_RS25275	COG2723	6-phospho-beta-galactosidase activity
CHR53_RS25280	COG2207	Transcriptional regulator
CHR53_RS25280	COG4753	response regulator
CHR53_RS25285	COG2972	Histidine kinase
CHR53_RS25290	COG1653	transport
CHR53_RS25295	COG0395	ABC-type sugar transport system, permease component
CHR53_RS25300	COG4209	transmembrane transport
CHR53_RS25325	COG5578	integral membrane protein
CHR53_RS25335	COG0383	alpha-mannosidase activity
CHR53_RS25355	COG3291	Pkd domain containing protein
CHR53_RS25355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CHR53_RS25360	COG3291	Pkd domain containing protein
CHR53_RS25360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CHR53_RS25365	COG1482	cell wall glycoprotein biosynthetic process
CHR53_RS25375	COG0395	ABC-type sugar transport system, permease component
CHR53_RS25380	COG1175	transmembrane transport
CHR53_RS25390	COG2197	response regulator
CHR53_RS25395	COG2972	Histidine kinase
CHR53_RS25405	COG3250	beta-galactosidase activity
CHR53_RS25415	COG0330	HflC and HflK could
CHR53_RS25420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS25445	COG1414	Transcriptional regulator
CHR53_RS25455	COG1830	Aldolase
CHR53_RS25460	COG1879	ABC-type sugar transport system periplasmic component
CHR53_RS25470	COG1172	Belongs to the binding-protein-dependent transport system permease family
CHR53_RS25485	COG1070	Carbohydrate kinase
CHR53_RS25495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHR53_RS25515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHR53_RS25515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHR53_RS25530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHR53_RS25535	COG4565	transcriptional regulatory protein
CHR53_RS25540	COG3290	protein histidine kinase activity
CHR53_RS25550	COG2207	Transcriptional regulator
CHR53_RS25555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CHR53_RS25560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CHR53_RS25565	COG2086	electron transfer activity
CHR53_RS25570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CHR53_RS25575	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS25580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHR53_RS25585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS25590	COG3800	Transcriptional regulator
CHR53_RS25590	COG1396	sequence-specific DNA binding
CHR53_RS25595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR53_RS25600	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS25625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CHR53_RS25630	COG2188	Transcriptional regulator
CHR53_RS25635	COG1994	Peptidase M50
CHR53_RS25650	COG2814	Major facilitator Superfamily
CHR53_RS25655	COG2897	thiosulfate sulfurtransferase activity
CHR53_RS25660	COG1737	Transcriptional regulator
CHR53_RS25665	COG1473	amidohydrolase
CHR53_RS25675	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS25680	COG3949	Membrane
CHR53_RS25695	COG2066	Belongs to the glutaminase family
CHR53_RS25700	COG1473	amidohydrolase
CHR53_RS25705	COG2271	Major facilitator Superfamily
CHR53_RS25720	COG2188	Transcriptional regulator
CHR53_RS25725	COG4221	oxidoreductase activity
CHR53_RS25740	COG2897	thiosulfate sulfurtransferase activity
CHR53_RS25750	COG1414	Transcriptional regulator
CHR53_RS25755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS25765	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS25770	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS25775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR53_RS25780	COG0601	transmembrane transport
CHR53_RS25785	COG0747	negative chemotaxis
CHR53_RS25790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CHR53_RS25795	COG1984	allophanate hydrolase subunit 2
CHR53_RS25800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CHR53_RS25805	COG1802	Transcriptional regulator
CHR53_RS25815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHR53_RS25820	COG0477	Major facilitator Superfamily
CHR53_RS25825	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS25830	COG1473	amidohydrolase
CHR53_RS25835	COG4948	Mandelate Racemase Muconate Lactonizing
CHR53_RS25840	COG4608	Belongs to the ABC transporter superfamily
CHR53_RS25845	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS25855	COG0601	transmembrane transport
CHR53_RS25875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR53_RS25930	COG1940	carbohydrate kinase activity
CHR53_RS25940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHR53_RS25950	COG0444	Belongs to the ABC transporter superfamily
CHR53_RS25960	COG0601	transmembrane transport
CHR53_RS25965	COG0747	negative chemotaxis
CHR53_RS25985	COG1288	antiporter activity
CHR53_RS25990	COG1473	amidohydrolase
CHR53_RS25995	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS26000	COG0028	Belongs to the TPP enzyme family
CHR53_RS26015	COG1473	amidohydrolase
CHR53_RS26020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHR53_RS26030	COG0436	Aminotransferase
CHR53_RS26080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CHR53_RS26090	COG0196	riboflavin kinase activity
CHR53_RS26095	COG0196	riboflavin kinase activity
CHR53_RS26110	COG0583	DNA-binding transcription factor activity
CHR53_RS26115	COG1115	amino acid carrier protein
CHR53_RS26125	COG1929	Belongs to the glycerate kinase type-1 family
CHR53_RS26130	COG1012	belongs to the aldehyde dehydrogenase family
CHR53_RS26135	COG4670	ketone body catabolic process
CHR53_RS26140	COG1454	alcohol dehydrogenase
CHR53_RS26185	COG1028	Short-chain dehydrogenase reductase Sdr
CHR53_RS26190	COG0183	Belongs to the thiolase family
CHR53_RS26195	COG1609	Transcriptional regulator
CHR53_RS26200	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHR53_RS26225	COG0778	Nitroreductase
CHR53_RS26230	COG1733	regulation of RNA biosynthetic process
CHR53_RS26235	COG4533	DNA binding
CHR53_RS26245	COG3239	Fatty acid desaturase
CHR53_RS26250	COG2197	response regulator
CHR53_RS26260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CHR53_RS26275	COG3829	transcription factor binding
CHR53_RS26290	COG0728	peptidoglycan biosynthetic process
CHR53_RS26305	COG0438	transferase activity, transferring glycosyl groups
CHR53_RS26320	COG0463	Glycosyl transferase, family 2
CHR53_RS26335	COG1086	Polysaccharide biosynthesis protein
CHR53_RS26350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHR53_RS26355	COG1086	Polysaccharide biosynthesis protein
CHR53_RS26360	COG4464	protein tyrosine phosphatase activity
CHR53_RS26365	COG0489	protein tyrosine kinase activity
CHR53_RS26370	COG3944	biosynthesis protein
CHR53_RS26380	COG0668	transmembrane transport
CHR53_RS26395	COG4499	WXG100 protein secretion system (Wss), protein YukC
CHR53_RS26395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR53_RS26435	COG2304	oxidoreductase activity
CHR53_RS26445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHR53_RS26450	COG1473	amidohydrolase
CHR53_RS26470	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CHR53_RS26485	COG1388	LysM domain
CHR53_RS26485	COG0791	NLP P60 protein
CHR53_RS26490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR53_RS26495	COG1473	amidohydrolase
CHR53_RS26500	COG2610	gluconate transmembrane transporter activity
CHR53_RS26505	COG1929	Belongs to the glycerate kinase type-1 family
CHR53_RS26510	COG3835	regulator
CHR53_RS26530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHR53_RS26535	COG3584	3D domain protein
CHR53_RS26535	COG3583	domain protein
CHR53_RS26575	COG3695	enzyme binding
CHR53_RS26580	COG0768	penicillin binding
CHR53_RS26585	COG0739	heme binding
CHR53_RS26595	COG2385	sporulation resulting in formation of a cellular spore
CHR53_RS26610	COG4836	Membrane
CHR53_RS26630	COG2261	transglycosylase associated protein
CHR53_RS26640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CHR53_RS26645	COG2205	protein histidine kinase activity
CHR53_RS26645	COG0784	Response regulator, receiver
CHR53_RS26650	COG0783	Belongs to the Dps family
CHR53_RS26660	COG2208	phosphoserine phosphatase activity
CHR53_RS26665	COG1191	sigma factor activity
CHR53_RS26670	COG2172	sigma factor antagonist activity
CHR53_RS26680	COG2814	Major facilitator Superfamily
CHR53_RS26685	COG1846	Transcriptional regulator
CHR53_RS26690	COG1619	proteins homologs of microcin C7 resistance protein MccF
CHR53_RS26715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHR53_RS26735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHR53_RS26755	COG0598	Magnesium transport protein CorA
CHR53_RS26780	COG0477	Major facilitator Superfamily
CHR53_RS26790	COG1253	flavin adenine dinucleotide binding
CHR53_RS26795	COG0668	transmembrane transport
CHR53_RS26810	COG1007	ATP synthesis coupled electron transport
CHR53_RS26820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHR53_RS26825	COG0713	ATP synthesis coupled electron transport
CHR53_RS26830	COG0839	Belongs to the complex I subunit 6 family
CHR53_RS26840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CHR53_RS26845	COG0649	NAD binding
CHR53_RS26850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHR53_RS26855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHR53_RS26860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CHR53_RS26870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHR53_RS26875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHR53_RS26880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHR53_RS26885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHR53_RS26890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHR53_RS26895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHR53_RS26900	COG0356	it plays a direct role in the translocation of protons across the membrane
CHR53_RS26915	COG1404	Belongs to the peptidase S8 family
CHR53_RS26925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CHR53_RS26940	COG0698	ribose 5-phosphate isomerase
CHR53_RS26950	COG1971	Probably functions as a manganese efflux pump
CHR53_RS26955	COG0009	L-threonylcarbamoyladenylate synthase
CHR53_RS26975	COG2890	protein-(glutamine-N5) methyltransferase activity
CHR53_RS26980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHR53_RS26990	COG1435	thymidine kinase activity
CHR53_RS27000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CHR53_RS27005	COG1494	fructose-1,6-bisphosphatase
CHR53_RS27015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CHR53_RS27020	COG0191	fructose-bisphosphate aldolase activity
CHR53_RS27025	COG2204	response regulator
CHR53_RS27030	COG4821	SIS domain
CHR53_RS27035	COG0504	CTP synthase activity
CHR53_RS27040	COG3343	RNA polymerase activity
CHR53_RS27045	COG1703	isobutyryl-CoA mutase activity
CHR53_RS27045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CHR53_RS27045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CHR53_RS27055	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS27060	COG1960	acyl-CoA dehydrogenase activity
CHR53_RS27065	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHR53_RS27070	COG0183	Belongs to the thiolase family
CHR53_RS27075	COG0247	lactate metabolic process
CHR53_RS27075	COG2181	nitrate reductase activity
CHR53_RS27080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHR53_RS27090	COG4506	Protein conserved in bacteria
CHR53_RS27095	COG0010	Belongs to the arginase family
CHR53_RS27100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CHR53_RS27105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR53_RS27115	COG1994	Peptidase M50
CHR53_RS27130	COG3465	dGTPase activity
CHR53_RS27135	COG1078	dGTPase activity
CHR53_RS27155	COG0280	phosphate acetyltransferase
CHR53_RS27160	COG3253	May function as heme-dependent peroxidase
CHR53_RS27170	COG2363	Small membrane protein
CHR53_RS27180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHR53_RS27190	COG0314	molybdopterin synthase activity
CHR53_RS27195	COG0303	'Molybdopterin
CHR53_RS27200	COG0303	'Molybdopterin
CHR53_RS27220	COG0437	4 iron, 4 sulfur cluster binding
CHR53_RS27230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CHR53_RS27235	COG0351	phosphomethylpyrimidine kinase
CHR53_RS27255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CHR53_RS27295	COG1131	(ABC) transporter
CHR53_RS27305	COG2133	pyrroloquinoline quinone binding
CHR53_RS27310	COG0561	phosphatase activity
CHR53_RS27325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHR53_RS27340	COG0411	ABC transporter
CHR53_RS27360	COG0477	Major facilitator Superfamily
CHR53_RS27365	COG1132	(ABC) transporter
CHR53_RS27370	COG1132	(ABC) transporter
CHR53_RS27390	COG0003	Pfam Anion-transporting ATPase
CHR53_RS27425	COG1131	(ABC) transporter
CHR53_RS27440	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHR53_RS27450	COG0069	glutamate synthase activity
CHR53_RS27455	COG0583	DNA-binding transcription factor activity
CHR53_RS27460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHR53_RS27485	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS27490	COG1376	ErfK ybiS ycfS ynhG family protein
CHR53_RS27495	COG0402	S-adenosylhomocysteine deaminase activity
CHR53_RS27500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CHR53_RS27505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHR53_RS27520	COG3584	3D domain protein
CHR53_RS27520	COG1388	LysM domain
CHR53_RS27525	COG2031	fatty acid transporter
CHR53_RS27530	COG1051	belongs to the nudix hydrolase family
CHR53_RS27540	COG4260	virion core protein, lumpy skin disease virus
CHR53_RS27545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CHR53_RS27550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHR53_RS27555	COG1842	Phage shock protein A
CHR53_RS27585	COG2133	pyrroloquinoline quinone binding
CHR53_RS27590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CHR53_RS27595	COG0157	Belongs to the NadC ModD family
CHR53_RS27600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CHR53_RS27610	COG2814	Major facilitator Superfamily
CHR53_RS27625	COG0579	oxidoreductase
CHR53_RS27630	COG0583	DNA-binding transcription factor activity
CHR53_RS27650	COG0577	efflux transmembrane transporter activity
CHR53_RS27655	COG1136	(ABC) transporter
CHR53_RS27665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHR53_RS27695	COG2391	methyltransferase activity
CHR53_RS27755	COG0778	Nitroreductase
CHR53_RS27760	COG1187	pseudouridine synthase activity
CHR53_RS27765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHR53_RS27775	COG2169	Transcriptional regulator
CHR53_RS27785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHR53_RS27795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHR53_RS27800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHR53_RS27805	COG4853	Protein conserved in bacteria
CHR53_RS27810	COG4863	YycH protein
CHR53_RS27815	COG5002	protein histidine kinase activity
CHR53_RS27820	COG0745	RESPONSE REGULATOR receiver
CHR53_RS27825	COG0741	lytic transglycosylase activity
CHR53_RS27825	COG1196	nuclear chromosome segregation
CHR53_RS27825	COG0739	heme binding
CHR53_RS27855	COG0305	Participates in initiation and elongation during chromosome replication
CHR53_RS27860	COG0359	binds to the 23S rRNA
CHR53_RS27865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CHR53_RS27870	COG4241	membrane
CHR53_RS27875	COG1910	domain protein
CHR53_RS27880	COG0725	ABC transporter, periplasmic molybdate-binding protein
CHR53_RS27885	COG4149	molybdate abc transporter
CHR53_RS27890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHR53_RS27900	COG0360	Binds together with S18 to 16S ribosomal RNA
CHR53_RS27905	COG0012	GTP binding
CHR53_RS27925	COG4193	domain, Protein
CHR53_RS27930	COG0243	molybdopterin cofactor binding
CHR53_RS27935	COG4481	Protein conserved in bacteria
CHR53_RS27940	COG0668	transmembrane transport
CHR53_RS27955	COG1475	DNA binding
CHR53_RS27960	COG1192	Involved in chromosome partitioning
CHR53_RS27965	COG1475	DNA binding
CHR53_RS27970	COG0357	Ribosomal RNA small subunit methyltransferase G
CHR53_RS27975	COG0445	tRNA wobble uridine modification
CHR53_RS27980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CHR53_RS27985	COG1847	R3H domain protein
CHR53_RS27995	COG0594	ribonuclease P activity