locus-tag	class	description
C0971_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0971_RS00010	COG0592	DNA-directed DNA polymerase activity
C0971_RS00015	COG2501	S4 domain
C0971_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0971_RS00025	COG0187	DNA topoisomerase II activity
C0971_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0971_RS00070	COG0516	GMP reductase activity
C0971_RS00070	COG0517	IMP dehydrogenase activity
C0971_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0971_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0971_RS00100	COG1428	Deoxynucleoside kinase
C0971_RS00105	COG1428	Deoxynucleoside kinase
C0971_RS00110	COG1388	LysM domain
C0971_RS00110	COG3858	chitin binding
C0971_RS00115	COG0590	tRNA wobble adenosine to inosine editing
C0971_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0971_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0971_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0971_RS00180	COG1982	Orn Lys Arg decarboxylase major
C0971_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0971_RS00190	COG3870	Protein conserved in bacteria
C0971_RS00195	COG1728	Protein conserved in bacteria
C0971_RS00200	COG0470	DNA polymerase III
C0971_RS00205	COG1774	PSP1 C-terminal conserved region
C0971_RS00210	COG4467	Involved in initiation control of chromosome replication
C0971_RS00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C0971_RS00220	COG2827	Endonuclease containing a URI domain
C0971_RS00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0971_RS00230	COG2002	toxin-antitoxin pair type II binding
C0971_RS00240	COG0084	hydrolase, TatD family'
C0971_RS00245	COG3583	domain protein
C0971_RS00245	COG3584	3D domain protein
C0971_RS00255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0971_RS00265	COG4466	Protein conserved in bacteria
C0971_RS00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_RS00285	COG0251	oxidation-reduction process
C0971_RS00290	COG2088	sporulation resulting in formation of a cellular spore
C0971_RS00295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0971_RS00305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0971_RS00310	COG0193	aminoacyl-tRNA hydrolase activity
C0971_RS00320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0971_RS00325	COG2002	toxin-antitoxin pair type II binding
C0971_RS00330	COG2244	polysaccharide biosynthetic process
C0971_RS00335	COG3956	TIGRFAM MazG family protein
C0971_RS00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C0971_RS00360	COG1098	S1 RNA binding domain
C0971_RS00370	COG2208	phosphoserine phosphatase activity
C0971_RS00375	COG2304	oxidoreductase activity
C0971_RS00380	COG0515	serine threonine protein kinase
C0971_RS00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C0971_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0971_RS00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0971_RS00410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0971_RS00415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_RS00420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0971_RS00425	COG0512	Glutamine amidotransferase of anthranilate synthase
C0971_RS00430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_RS00435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0971_RS00440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0971_RS00445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0971_RS00450	COG1396	sequence-specific DNA binding
C0971_RS00455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0971_RS00550	COG3880	PFAM UvrB UvrC protein
C0971_RS00555	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C0971_RS00560	COG0542	response to heat
C0971_RS00565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0971_RS00570	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0971_RS00575	COG4956	integral membrane protein (PIN domain superfamily)
C0971_RS00585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0971_RS00590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0971_RS00595	COG1045	serine acetyltransferase
C0971_RS00600	COG0215	cysteine-tRNA ligase activity
C0971_RS00610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0971_RS00615	COG3688	RNA-binding protein containing a PIN domain
C0971_RS00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_RS00630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0971_RS00635	COG0250	Participates in transcription elongation, termination and antitermination
C0971_RS00640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0971_RS00645	COG0081	regulation of translation
C0971_RS00650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0971_RS00655	COG0222	ribosome binding
C0971_RS00660	COG2813	Specifically methylates the guanine in position
C0971_RS00665	COG0085	RNA polymerase activity
C0971_RS00670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0971_RS00675	COG1358	cellular component organization or biogenesis
C0971_RS00680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0971_RS00685	COG0049	tRNA binding
C0971_RS00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0971_RS00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0971_RS00700	COG0051	transcription antitermination factor activity, RNA binding
C0971_RS00705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0971_RS00710	COG0088	Forms part of the polypeptide exit tunnel
C0971_RS00720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0971_RS00725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0971_RS00730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0971_RS00735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0971_RS00740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0971_RS00745	COG0255	Belongs to the universal ribosomal protein uL29 family
C0971_RS00755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0971_RS00760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0971_RS00780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0971_RS00785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0971_RS00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0971_RS00795	COG1841	ribosomal large subunit assembly
C0971_RS00805	COG0201	protein transport
C0971_RS00810	COG0563	adenylate kinase activity
C0971_RS00815	COG0024	Methionine aminopeptidase
C0971_RS00820	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C0971_RS00825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0971_RS00830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0971_RS00835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0971_RS00840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0971_RS00850	COG0203	ribosomal protein L17
C0971_RS00855	COG1122	ATPase activity
C0971_RS00860	COG1122	ATPase activity
C0971_RS00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C0971_RS00880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0971_RS00885	COG0582	viral genome integration into host DNA
C0971_RS00900	COG2855	membrane
C0971_RS00905	COG0583	DNA-binding transcription factor activity
C0971_RS00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_RS00945	COG0489	protein tyrosine kinase activity
C0971_RS00955	COG2194	sulfuric ester hydrolase activity
C0971_RS00960	COG0726	polysaccharide deacetylase
C0971_RS01055	COG1595	DNA-templated transcription, initiation
C0971_RS01060	COG5662	AntiSigma factor
C0971_RS01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C0971_RS01070	COG4856	YbbR-like protein
C0971_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0971_RS01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0971_RS01085	COG1113	amino acid transport
C0971_RS01105	COG1132	(ABC) transporter
C0971_RS01115	COG2267	carboxylic ester hydrolase activity
C0971_RS01125	COG3711	transcriptional antiterminator
C0971_RS01140	COG0346	lactoylglutathione lyase activity
C0971_RS01150	COG0352	thiamine-phosphate diphosphorylase activity
C0971_RS01155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_RS01165	COG2022	thiamine diphosphate biosynthetic process
C0971_RS01170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0971_RS01175	COG1070	Carbohydrate kinase
C0971_RS01190	COG1174	glycine betaine transport
C0971_RS01195	COG1125	glycine betaine transport
C0971_RS01195	COG0517	IMP dehydrogenase activity
C0971_RS01200	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C0971_RS01215	COG0531	amino acid
C0971_RS01220	COG2135	peptidase activity
C0971_RS01225	COG2239	Acts as a magnesium transporter
C0971_RS01235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0971_RS01240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_RS01245	COG1120	ATPase activity
C0971_RS01250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0971_RS01265	COG1492	cobalamin metabolic process
C0971_RS01270	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C0971_RS01285	COG2096	Adenosyltransferase
C0971_RS01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0971_RS01320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0971_RS01330	COG0513	Belongs to the DEAD box helicase family
C0971_RS01335	COG3402	PFAM membrane-flanked domain
C0971_RS01340	COG3428	Bacterial PH domain
C0971_RS01345	COG0705	Rhomboid family
C0971_RS01350	COG0736	holo-[acyl-carrier-protein] synthase activity
C0971_RS01355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0971_RS01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0971_RS01365	COG0864	Transcriptional regulator
C0971_RS01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
C0971_RS01375	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_RS01380	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_RS01385	COG2172	sigma factor antagonist activity
C0971_RS01390	COG2208	phosphoserine phosphatase activity
C0971_RS01395	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_RS01405	COG1191	sigma factor activity
C0971_RS01410	COG2208	phosphoserine phosphatase activity
C0971_RS01415	COG2183	response to ionizing radiation
C0971_RS01425	COG3091	SprT-like family
C0971_RS01515	COG0802	atpase or kinase
C0971_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
C0971_RS01525	COG0456	acetyltransferase
C0971_RS01535	COG0488	(ABC) transporter
C0971_RS01540	COG0315	cyclic pyranopterin monophosphate synthase activity
C0971_RS01545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C0971_RS01555	COG1266	CAAX protease self-immunity
C0971_RS01560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0971_RS01565	COG0459	protein refolding
C0971_RS01605	COG2304	oxidoreductase activity
C0971_RS01615	COG0463	Glycosyl transferase, family 2
C0971_RS01625	COG0714	Associated with various cellular activities
C0971_RS01630	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C0971_RS01635	COG1305	Transglutaminase-like
C0971_RS01640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0971_RS01640	COG0519	Catalyzes the synthesis of GMP from XMP
C0971_RS01645	COG2252	PERMEase
C0971_RS01650	COG3711	transcriptional antiterminator
C0971_RS01655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0971_RS01655	COG1263	PTS System
C0971_RS01655	COG2190	(PTS) system
C0971_RS01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0971_RS01690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0971_RS01695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0971_RS01700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0971_RS01705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0971_RS01710	COG0047	phosphoribosylformylglycinamidine synthase activity
C0971_RS01715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0971_RS01720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0971_RS01725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0971_RS01730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0971_RS01735	COG0138	bifunctional purine biosynthesis protein purh
C0971_RS01740	COG0151	Belongs to the GarS family
C0971_RS01755	COG1470	cell adhesion involved in biofilm formation
C0971_RS01760	COG4496	protein, YerC YecD
C0971_RS01765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C0971_RS01770	COG0210	DNA helicase
C0971_RS01775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0971_RS01780	COG4851	CamS sex pheromone cAM373 precursor
C0971_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS01790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0971_RS01795	COG2224	Isocitrate lyase
C0971_RS01805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0971_RS01810	COG0154	amidase activity
C0971_RS01840	COG0789	Transcriptional regulator
C0971_RS01845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0971_RS01850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0971_RS01860	COG1968	undecaprenyl-diphosphatase activity
C0971_RS01865	COG1597	lipid kinase activity
C0971_RS01870	COG1404	Belongs to the peptidase S8 family
C0971_RS01875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C0971_RS01885	COG0183	Belongs to the thiolase family
C0971_RS01890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_RS01895	COG1960	acyl-CoA dehydrogenase activity
C0971_RS01900	COG1464	Belongs to the NlpA lipoprotein family
C0971_RS01905	COG0531	amino acid
C0971_RS01910	COG3540	Alkaline phosphatase
C0971_RS01940	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C0971_RS01960	COG0579	oxidoreductase
C0971_RS01990	COG0583	DNA-binding transcription factor activity
C0971_RS01995	COG0070	glutamate synthase
C0971_RS01995	COG0069	glutamate synthase activity
C0971_RS01995	COG0067	glutamate synthase
C0971_RS02000	COG0493	'glutamate synthase
C0971_RS02005	COG1278	Cold shock
C0971_RS02010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_RS02015	COG2814	Major facilitator Superfamily
C0971_RS02020	COG2720	vancomycin resistance protein
C0971_RS02025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0971_RS02030	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C0971_RS02035	COG3853	Toxic anion resistance protein (TelA)
C0971_RS02045	COG4549	nuclear export factor GLE1
C0971_RS02050	COG2372	response to copper ion
C0971_RS02050	COG1276	copper resistance
C0971_RS02080	COG0010	Belongs to the arginase family
C0971_RS02095	COG0656	L-ascorbic acid biosynthetic process
C0971_RS02100	COG1309	transcriptional regulator
C0971_RS02105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_RS02110	COG0765	amino acid transport
C0971_RS02115	COG1126	abc transporter atp-binding protein
C0971_RS02135	COG0640	Transcriptional regulator
C0971_RS02140	COG0346	lactoylglutathione lyase activity
C0971_RS02145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0971_RS02150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0971_RS02155	COG0640	Transcriptional regulator
C0971_RS02165	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C0971_RS02205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_RS02215	COG0805	protein transport
C0971_RS02230	COG0523	cobalamin synthesis protein
C0971_RS02235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_RS02250	COG1755	Isoprenylcysteine carboxyl methyltransferase
C0971_RS02315	COG0475	glutathione-regulated potassium exporter activity
C0971_RS02360	COG0004	ammonium transporteR
C0971_RS02410	COG5577	PFAM Coat F domain
C0971_RS02425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0971_RS02495	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C0971_RS02515	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_RS02525	COG0463	Glycosyl transferase, family 2
C0971_RS02545	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS02565	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C0971_RS02575	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0971_RS02585	COG0375	protein maturation
C0971_RS02590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0971_RS02595	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C0971_RS02600	COG0298	carbon dioxide binding
C0971_RS02605	COG0409	Hydrogenase expression formation protein
C0971_RS02615	COG0671	phosphoesterase, PA-phosphatase related
C0971_RS02620	COG5002	protein histidine kinase activity
C0971_RS02625	COG0745	RESPONSE REGULATOR receiver
C0971_RS02645	COG1151	hydroxylamine reductase activity
C0971_RS02650	COG0437	4 iron, 4 sulfur cluster binding
C0971_RS02655	COG0651	ATP synthesis coupled electron transport
C0971_RS02660	COG0650	Formate hydrogenlyase subunit 4
C0971_RS02665	COG4237	Hydrogenase 4 membrane
C0971_RS02670	COG0651	ATP synthesis coupled electron transport
C0971_RS02675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0971_RS02680	COG3261	NADH dehydrogenase
C0971_RS02680	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C0971_RS02685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_RS02690	COG3260	NADH ubiquinone oxidoreductase 20
C0971_RS02700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0971_RS02705	COG0375	protein maturation
C0971_RS02710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0971_RS02715	COG1509	lysine 2,3-aminomutase activity
C0971_RS02745	COG1587	Uroporphyrinogen-III synthase
C0971_RS02750	COG0175	sulfate reduction
C0971_RS02755	COG2046	Belongs to the sulfate adenylyltransferase family
C0971_RS02760	COG0529	Catalyzes the synthesis of activated sulfate
C0971_RS02765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_RS02785	COG1648	precorrin-2 dehydrogenase activity
C0971_RS02790	COG0730	response to heat
C0971_RS02795	COG1388	LysM domain
C0971_RS02795	COG3584	3D domain protein
C0971_RS02800	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS02800	COG1454	alcohol dehydrogenase
C0971_RS02805	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS02805	COG1454	alcohol dehydrogenase
C0971_RS02820	COG0310	cobalt ion transport
C0971_RS02830	COG1122	ATPase activity
C0971_RS02840	COG0535	radical SAM domain protein
C0971_RS02855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0971_RS02860	COG1984	allophanate hydrolase subunit 2
C0971_RS02865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C0971_RS02870	COG1114	Component of the transport system for branched-chain amino acids
C0971_RS02890	COG0514	ATP-dependent DNA helicase (RecQ)
C0971_RS02895	COG3858	chitin binding
C0971_RS02895	COG1388	LysM domain
C0971_RS02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_RS02910	COG0765	amino acid transport
C0971_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS02925	COG5002	protein histidine kinase activity
C0971_RS02950	COG2879	small protein
C0971_RS02955	COG1966	Carbon starvation protein
C0971_RS02960	COG2176	DNA-directed DNA polymerase activity
C0971_RS02970	COG0004	ammonium transporteR
C0971_RS02985	COG2706	6-phosphogluconolactonase activity
C0971_RS02995	COG2814	Major facilitator Superfamily
C0971_RS03020	COG0765	amino acid transport
C0971_RS03030	COG2966	Psort location CytoplasmicMembrane, score
C0971_RS03035	COG3610	response to peptide
C0971_RS03040	COG2207	Transcriptional regulator
C0971_RS03045	COG1653	transport
C0971_RS03065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0971_RS03070	COG3773	Cell wall hydrolase
C0971_RS03080	COG0573	inorganic phosphate transmembrane transporter activity
C0971_RS03085	COG0581	inorganic phosphate transmembrane transporter activity
C0971_RS03090	COG0789	Transcriptional regulator
C0971_RS03105	COG0346	lactoylglutathione lyase activity
C0971_RS03125	COG0745	RESPONSE REGULATOR receiver
C0971_RS03130	COG2205	protein histidine kinase activity
C0971_RS03145	COG3275	phosphorelay sensor kinase activity
C0971_RS03155	COG1966	Carbon starvation protein
C0971_RS03160	COG0531	amino acid
C0971_RS03165	COG2848	UPF0210 protein
C0971_RS03170	COG3830	Belongs to the UPF0237 family
C0971_RS03175	COG0351	phosphomethylpyrimidine kinase
C0971_RS03185	COG0513	Belongs to the DEAD box helicase family
C0971_RS03190	COG0626	cystathionine gamma-synthase activity
C0971_RS03200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_RS03205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS03215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_RS03220	COG0460	homoserine dehydrogenase
C0971_RS03225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0971_RS03250	COG2197	response regulator
C0971_RS03255	COG3104	oligopeptide transport
C0971_RS03260	COG2244	polysaccharide biosynthetic process
C0971_RS03265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0971_RS03270	COG1254	Belongs to the acylphosphatase family
C0971_RS03275	COG2309	aminopeptidase activity
C0971_RS03290	COG2080	2 iron, 2 sulfur cluster binding
C0971_RS03300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0971_RS03305	COG0789	Transcriptional regulator
C0971_RS03330	COG5002	protein histidine kinase activity
C0971_RS03340	COG1842	Phage shock protein A
C0971_RS03345	COG0494	nUDIX hydrolase
C0971_RS03350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C0971_RS03375	COG2986	histidine ammonia-lyase
C0971_RS03390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0971_RS03395	COG1360	Flagellar Motor Protein
C0971_RS03400	COG0024	Methionine aminopeptidase
C0971_RS03405	COG4840	Belongs to the UPF0435 family
C0971_RS03415	COG1295	ribonuclease BN
C0971_RS03420	COG2217	Heavy metal translocating P-type atpase
C0971_RS03425	COG0477	Major facilitator Superfamily
C0971_RS03430	COG0387	Pfam Sodium calcium exchanger
C0971_RS03440	COG0535	radical SAM domain protein
C0971_RS03455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C0971_RS03460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0971_RS03480	COG0701	Predicted permease
C0971_RS03485	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0971_RS03500	COG2226	methyltransferase
C0971_RS03505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0971_RS03510	COG1228	amidohydrolase
C0971_RS03515	COG0010	Belongs to the arginase family
C0971_RS03530	COG1090	epimerase
C0971_RS03560	COG1988	membrane-bound metal-dependent
C0971_RS03570	COG1194	a g-specific adenine glycosylase
C0971_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_RS03600	COG1132	(ABC) transporter
C0971_RS03610	COG4129	membrane
C0971_RS03615	COG0069	glutamate synthase activity
C0971_RS03615	COG0067	glutamate synthase
C0971_RS03615	COG0070	glutamate synthase
C0971_RS03620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0971_RS03625	COG4555	ABC transporter
C0971_RS03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0971_RS03650	COG0735	belongs to the Fur family
C0971_RS03760	COG4974	Belongs to the 'phage' integrase family
C0971_RS03785	COG1715	Restriction endonuclease
C0971_RS03800	COG4974	Belongs to the 'phage' integrase family
C0971_RS03810	COG0367	asparagine synthase
C0971_RS03855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C0971_RS03860	COG0573	inorganic phosphate transmembrane transporter activity
C0971_RS03865	COG0581	inorganic phosphate transmembrane transporter activity
C0971_RS03875	COG3382	B3 4 domain protein
C0971_RS03880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C0971_RS03890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0971_RS03895	COG0778	Nitroreductase
C0971_RS03900	COG2766	serine protein kinase
C0971_RS03905	COG2718	Belongs to the UPF0229 family
C0971_RS03910	COG2094	Belongs to the DNA glycosylase MPG family
C0971_RS03915	COG0628	permease
C0971_RS03920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_RS03925	COG0306	phosphate transporter
C0971_RS03930	COG1392	Phosphate transport regulator
C0971_RS03935	COG0655	NAD(P)H dehydrogenase (quinone) activity
C0971_RS03940	COG2261	transglycosylase associated protein
C0971_RS03945	COG0564	pseudouridine synthase activity
C0971_RS03960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0971_RS03965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0971_RS03980	COG2719	SpoVR family
C0971_RS03985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_RS03990	COG1271	oxidase subunit
C0971_RS03995	COG1294	oxidase, subunit
C0971_RS04000	COG4988	ABC transporter
C0971_RS04005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0971_RS04030	COG1940	carbohydrate kinase activity
C0971_RS04035	COG0561	phosphatase activity
C0971_RS04040	COG3689	TIGRFAM TIGR03943 family protein
C0971_RS04045	COG0701	Predicted permease
C0971_RS04050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_RS04055	COG0745	RESPONSE REGULATOR receiver
C0971_RS04060	COG3850	Histidine kinase
C0971_RS04060	COG5002	protein histidine kinase activity
C0971_RS04065	COG1368	sulfuric ester hydrolase activity
C0971_RS04070	COG1253	flavin adenine dinucleotide binding
C0971_RS04075	COG0789	Transcriptional regulator
C0971_RS04080	COG1253	flavin adenine dinucleotide binding
C0971_RS04085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0971_RS04090	COG3852	Histidine kinase
C0971_RS04095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0971_RS04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_RS04125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0971_RS04130	COG0114	fumarate hydratase activity
C0971_RS04145	COG3842	ATPase activity
C0971_RS04150	COG2508	Transcriptional regulator
C0971_RS04165	COG0189	ligase activity
C0971_RS04170	COG0189	ligase activity
C0971_RS04180	COG3679	Belongs to the UPF0342 family
C0971_RS04185	COG0561	phosphatase activity
C0971_RS04190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0971_RS04195	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_RS04200	COG1024	Enoyl-CoA hydratase
C0971_RS04210	COG4152	abc transporter atp-binding protein
C0971_RS04215	COG1668	transmembrane transport
C0971_RS04220	COG0420	3'-5' exonuclease activity
C0971_RS04225	COG4717	serine-type aminopeptidase activity
C0971_RS04230	COG3481	metal-dependent phosphohydrolase, HD sub domain
C0971_RS04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0971_RS04260	COG1846	Transcriptional regulator
C0971_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
C0971_RS04295	COG1131	(ABC) transporter
C0971_RS04300	COG4473	ABC transporter
C0971_RS04310	COG1473	amidohydrolase
C0971_RS04320	COG2329	Antibiotic biosynthesis monooxygenase
C0971_RS04350	COG1346	cytolysis
C0971_RS04355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0971_RS04360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0971_RS04365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C0971_RS04370	COG1309	transcriptional regulator
C0971_RS04375	COG1511	domain protein
C0971_RS04385	COG1234	tRNA 3'-trailer cleavage
C0971_RS04400	COG1024	Enoyl-CoA hydratase
C0971_RS04415	COG1122	ATPase activity
C0971_RS04420	COG1396	sequence-specific DNA binding
C0971_RS04425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0971_RS04435	COG0501	Belongs to the peptidase M48B family
C0971_RS04450	COG5582	Belongs to the UPF0302 family
C0971_RS04455	COG4903	ComK protein
C0971_RS04470	COG0398	Pfam SNARE associated Golgi protein
C0971_RS04480	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C0971_RS04520	COG2311	Membrane
C0971_RS04525	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0971_RS04535	COG4585	Histidine kinase
C0971_RS04540	COG2197	response regulator
C0971_RS04545	COG1131	(ABC) transporter
C0971_RS04565	COG0367	asparagine synthase
C0971_RS04575	COG0366	Alpha amylase catalytic
C0971_RS04575	COG1874	Beta-galactosidase
C0971_RS04585	COG1666	GTP binding
C0971_RS04590	COG2996	Protein conserved in bacteria
C0971_RS04600	COG1307	EDD domain protein, DegV family
C0971_RS04605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_RS04625	COG0561	phosphatase activity
C0971_RS04630	COG1073	alpha beta
C0971_RS04635	COG2151	metal-sulfur cluster biosynthetic enzyme
C0971_RS04640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0971_RS04645	COG0303	'Molybdopterin
C0971_RS04650	COG1763	Mo-molybdopterin cofactor biosynthetic process
C0971_RS04655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0971_RS04660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0971_RS04665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0971_RS04675	COG0505	Belongs to the CarA family
C0971_RS04685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0971_RS04695	COG0542	response to heat
C0971_RS04705	COG2267	carboxylic ester hydrolase activity
C0971_RS04715	COG1744	ABC transporter substrate-binding protein PnrA-like
C0971_RS04725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0971_RS04730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0971_RS04735	COG5504	Zn-dependent protease
C0971_RS04760	COG0180	Tryptophanyl-tRNA synthetase
C0971_RS04765	COG4166	transmembrane transport
C0971_RS04770	COG0601	transmembrane transport
C0971_RS04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0971_RS04780	COG0444	Belongs to the ABC transporter superfamily
C0971_RS04785	COG4608	Belongs to the ABC transporter superfamily
C0971_RS04795	COG1393	Belongs to the ArsC family
C0971_RS04800	COG4862	establishment of competence for transformation
C0971_RS04805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0971_RS04815	COG1164	Oligoendopeptidase f
C0971_RS04820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0971_RS04825	COG2346	COG2346, Truncated hemoglobins
C0971_RS04830	COG0741	lytic transglycosylase activity
C0971_RS04835	COG4116	CYTH
C0971_RS04845	COG2357	RelA SpoT domain protein
C0971_RS04855	COG0564	pseudouridine synthase activity
C0971_RS04860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0971_RS04865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0971_RS04890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0971_RS04915	COG2153	protein acetylation
C0971_RS04920	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C0971_RS04925	COG0765	amino acid transport
C0971_RS04930	COG0765	amino acid transport
C0971_RS04935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_RS04940	COG1126	abc transporter atp-binding protein
C0971_RS04970	COG0701	Predicted permease
C0971_RS04975	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0971_RS05045	COG2197	response regulator
C0971_RS05050	COG4585	Histidine kinase
C0971_RS05055	COG1131	(ABC) transporter
C0971_RS05065	COG0842	Transport permease protein
C0971_RS05070	COG0693	protein deglycase activity
C0971_RS05075	COG1846	Transcriptional regulator
C0971_RS05080	COG4377	Putative membrane peptidase family (DUF2324)
C0971_RS05085	COG0626	cystathionine gamma-synthase activity
C0971_RS05095	COG2733	membrane
C0971_RS05100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0971_RS05105	COG2376	Dihydroxyacetone kinase
C0971_RS05115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0971_RS05115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS05115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C0971_RS05125	COG0753	catalase activity
C0971_RS05130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_RS05135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0971_RS05140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0971_RS05145	COG0438	transferase activity, transferring glycosyl groups
C0971_RS05160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_RS05165	COG0438	transferase activity, transferring glycosyl groups
C0971_RS05170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_RS05180	COG4242	Belongs to the peptidase S51 family
C0971_RS05185	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0971_RS05185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0971_RS05205	COG3773	Cell wall hydrolase
C0971_RS05215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0971_RS05230	COG1191	sigma factor activity
C0971_RS05270	COG3594	Acyltransferase
C0971_RS05275	COG0840	transmembrane signaling receptor activity
C0971_RS05280	COG5002	protein histidine kinase activity
C0971_RS05285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0971_RS05290	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C0971_RS05295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0971_RS05300	COG0436	Aminotransferase
C0971_RS05305	COG1850	ribulose-bisphosphate carboxylase activity
C0971_RS05310	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C0971_RS05315	COG0235	Class ii aldolase
C0971_RS05320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C0971_RS05330	COG2223	nitrite transmembrane transporter activity
C0971_RS05335	COG3852	Histidine kinase
C0971_RS05340	COG1846	Transcriptional regulator
C0971_RS05350	COG0542	response to heat
C0971_RS05355	COG3949	Membrane
C0971_RS05375	COG4873	Protein conserved in bacteria
C0971_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_RS05405	COG2084	Dehydrogenase
C0971_RS05410	COG0436	Aminotransferase
C0971_RS05420	COG1714	RDD family
C0971_RS05430	COG0835	chemotaxis
C0971_RS05430	COG0784	Response regulator, receiver
C0971_RS05440	COG5001	Diguanylate cyclase
C0971_RS05440	COG3300	MHYT domain
C0971_RS05445	COG1408	metallophosphoesterase
C0971_RS05450	COG4990	cell redox homeostasis
C0971_RS05455	COG2200	EAL domain
C0971_RS05475	COG4703	Protein of unknown function (DUF1797)
C0971_RS05480	COG0517	IMP dehydrogenase activity
C0971_RS05485	COG0477	Major facilitator Superfamily
C0971_RS05490	COG0583	DNA-binding transcription factor activity
C0971_RS05495	COG2171	N-acyltransferase activity
C0971_RS05500	COG1473	amidohydrolase
C0971_RS05505	COG0450	alkyl hydroperoxide reductase
C0971_RS05510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_RS05520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0971_RS05525	COG5503	Protein of unknown function (DUF1447)
C0971_RS05545	COG0022	dehydrogenase e1 component
C0971_RS05550	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_RS05575	COG1982	Orn Lys Arg decarboxylase major
C0971_RS05585	COG4476	Belongs to the UPF0223 family
C0971_RS05595	COG0483	inositol monophosphate 1-phosphatase activity
C0971_RS05600	COG1914	H( )-stimulated, divalent metal cation uptake system
C0971_RS05610	COG1217	gtp-binding protein TYPA
C0971_RS05625	COG4896	Protein conserved in bacteria
C0971_RS05640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0971_RS05645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0971_RS05650	COG4838	Belongs to the UPF0358 family
C0971_RS05655	COG0772	Belongs to the SEDS family
C0971_RS05660	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C0971_RS05665	COG1612	heme a metabolic process
C0971_RS05695	COG3336	cytochrome c oxidase
C0971_RS05705	COG0628	permease
C0971_RS05715	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C0971_RS05720	COG2340	Cysteine-rich secretory protein family
C0971_RS05745	COG3679	Belongs to the UPF0342 family
C0971_RS05750	COG4471	UPF0298 protein
C0971_RS05765	COG0742	ribosomal rna small subunit methyltransferase
C0971_RS05770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0971_RS05775	COG3314	Sporulation integral membrane protein YlbJ
C0971_RS05780	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0971_RS05785	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0971_RS05790	COG1323	Belongs to the UPF0348 family
C0971_RS05795	COG1399	metal-binding, possibly nucleic acid-binding protein
C0971_RS05800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0971_RS05805	COG1024	Enoyl-CoA hydratase
C0971_RS05815	COG0439	Biotin carboxylase
C0971_RS05820	COG0511	ligase activity, forming carbon-carbon bonds
C0971_RS05825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0971_RS05830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0971_RS05840	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C0971_RS05845	COG2001	Belongs to the MraZ family
C0971_RS05855	COG4839	cell division protein FtsL
C0971_RS05860	COG0768	penicillin binding
C0971_RS05865	COG0768	penicillin binding
C0971_RS05875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0971_RS05880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0971_RS05885	COG0772	Belongs to the SEDS family
C0971_RS05890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0971_RS05895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0971_RS05900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0971_RS05905	COG3879	Bacterial protein of unknown function (DUF881)
C0971_RS05910	COG3879	Bacterial protein of unknown function (DUF881)
C0971_RS05915	COG3856	small basic protein
C0971_RS05920	COG0849	cell division
C0971_RS05925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0971_RS05935	COG1191	sigma factor activity
C0971_RS05940	COG1191	sigma factor activity
C0971_RS05945	COG1873	PFAM PRC-barrel domain
C0971_RS05950	COG1496	oxidoreductase activity
C0971_RS05955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0971_RS05960	COG1799	cell septum assembly
C0971_RS05965	COG0762	integral membrane protein
C0971_RS05970	COG2302	S4 RNA-binding domain
C0971_RS05975	COG3599	regulation of cell shape
C0971_RS05980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0971_RS05985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0971_RS05990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0971_RS05995	COG0564	pseudouridine synthase activity
C0971_RS06000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0971_RS06010	COG0540	Belongs to the ATCase OTCase family
C0971_RS06015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0971_RS06025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0971_RS06030	COG0543	2 iron, 2 sulfur cluster binding
C0971_RS06035	COG0167	dihydroorotate dehydrogenase activity
C0971_RS06055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0971_RS06060	COG1561	YicC-like family, N-terminal region
C0971_RS06070	COG0194	GDP metabolic process
C0971_RS06075	COG1758	RNA polymerase activity
C0971_RS06080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0971_RS06085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0971_RS06095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0971_RS06100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0971_RS06100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0971_RS06105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0971_RS06110	COG0631	protein serine/threonine phosphatase activity
C0971_RS06115	COG0515	serine threonine protein kinase
C0971_RS06115	COG2815	serine threonine protein kinase
C0971_RS06125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0971_RS06130	COG1564	THIamine pyrophosphokinase
C0971_RS06145	COG1302	Protein conserved in bacteria
C0971_RS06150	COG1461	Dihydroxyacetone kinase
C0971_RS06155	COG1760	l-serine dehydratase
C0971_RS06160	COG1760	l-serine dehydratase
C0971_RS06165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0971_RS06170	COG1349	DNA-binding transcription factor activity
C0971_RS06175	COG0416	fatty acid biosynthetic process
C0971_RS06180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0971_RS06185	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_RS06190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0971_RS06200	COG1196	nuclear chromosome segregation
C0971_RS06205	COG0552	protein localization to endoplasmic reticulum
C0971_RS06215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0971_RS06220	COG0228	four-way junction DNA binding
C0971_RS06225	COG1837	Belongs to the UPF0109 family
C0971_RS06235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0971_RS06240	COG0336	Belongs to the RNA methyltransferase TrmD family
C0971_RS06245	COG0335	large ribosomal subunit rRNA binding
C0971_RS06255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0971_RS06260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0971_RS06275	COG0045	succinate-CoA ligase (ADP-forming) activity
C0971_RS06280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0971_RS06285	COG0758	DNA mediated transformation
C0971_RS06290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0971_RS06295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C0971_RS06300	COG4974	Belongs to the 'phage' integrase family
C0971_RS06305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0971_RS06310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C0971_RS06315	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C0971_RS06320	COG1815	bacterial-type flagellum-dependent cell motility
C0971_RS06325	COG1558	bacterial-type flagellum-dependent cell motility
C0971_RS06330	COG1677	Flagellar hook-basal body complex protein FliE
C0971_RS06335	COG1766	The M ring may be actively involved in energy transduction
C0971_RS06340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_RS06345	COG1317	bacterial-type flagellum organization
C0971_RS06350	COG1157	protein secretion by the type III secretion system
C0971_RS06355	COG2882	bacterial-type flagellum organization
C0971_RS06370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0971_RS06375	COG4786	Flagellar basal body rod
C0971_RS06380	COG1582	Flagellar protein (FlbD)
C0971_RS06385	COG1580	Controls the rotational direction of flagella during chemotaxis
C0971_RS06390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_RS06395	COG1776	CheC inhibitor of MCP methylation
C0971_RS06395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_RS06400	COG2201	protein-glutamate methylesterase activity
C0971_RS06405	COG3190	flagellar
C0971_RS06410	COG1338	Plays a role in the flagellum-specific transport system
C0971_RS06415	COG1987	bacterial-type flagellum assembly
C0971_RS06420	COG1684	flagellar biosynthetic protein fliR
C0971_RS06425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0971_RS06430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0971_RS06435	COG1419	protein localization to endoplasmic reticulum
C0971_RS06440	COG0455	bacterial-type flagellum organization
C0971_RS06445	COG2201	protein-glutamate methylesterase activity
C0971_RS06450	COG0643	Histidine kinase
C0971_RS06450	COG2198	Histidine kinase
C0971_RS06455	COG0835	chemotaxis
C0971_RS06460	COG1776	CheC inhibitor of MCP methylation
C0971_RS06470	COG1191	sigma factor activity
C0971_RS06480	COG0052	Belongs to the universal ribosomal protein uS2 family
C0971_RS06485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0971_RS06490	COG0528	UMP kinase activity
C0971_RS06495	COG0233	cytoplasmic translational termination
C0971_RS06500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0971_RS06505	COG4589	Belongs to the CDS family
C0971_RS06510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0971_RS06515	COG0750	zinc metalloprotease
C0971_RS06525	COG2176	DNA-directed DNA polymerase activity
C0971_RS06530	COG0779	Required for maturation of 30S ribosomal subunits
C0971_RS06535	COG0195	Participates in both transcription termination and antitermination
C0971_RS06540	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C0971_RS06545	COG1358	cellular component organization or biogenesis
C0971_RS06555	COG1550	Protein conserved in bacteria
C0971_RS06560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0971_RS06565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0971_RS06570	COG0196	riboflavin kinase activity
C0971_RS06575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0971_RS06580	COG1185	polyribonucleotide nucleotidyltransferase activity
C0971_RS06585	COG0726	polysaccharide deacetylase
C0971_RS06595	COG1873	PFAM PRC-barrel domain
C0971_RS06600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0971_RS06605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0971_RS06610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0971_RS06615	COG0527	aspartate kinase activity
C0971_RS06620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0971_RS06625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0971_RS06630	COG0740	serine-type endopeptidase activity
C0971_RS06640	COG4980	gas vesicle protein
C0971_RS06640	COG1674	ftsk spoiiie
C0971_RS06645	COG2188	Transcriptional regulator
C0971_RS06650	COG1744	ABC transporter substrate-binding protein PnrA-like
C0971_RS06655	COG3845	ABC transporter
C0971_RS06660	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0971_RS06665	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0971_RS06670	COG0612	Peptidase, M16
C0971_RS06675	COG0612	Peptidase, M16
C0971_RS06680	COG0300	oxidoreductase activity
C0971_RS06695	COG1426	Protein conserved in bacteria
C0971_RS06700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0971_RS06705	COG1058	Belongs to the CinA family
C0971_RS06705	COG1546	Belongs to the CinA family
C0971_RS06715	COG1418	mRNA catabolic process
C0971_RS06720	COG1692	metallophosphoesterase
C0971_RS06725	COG2359	stage V sporulation protein S
C0971_RS06730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0971_RS06730	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0971_RS06735	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0971_RS06740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0971_RS06745	COG4550	Control of competence regulator ComK, YlbF/YmcA
C0971_RS06760	COG0346	lactoylglutathione lyase activity
C0971_RS06765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0971_RS06770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0971_RS06775	COG1077	Cell shape determining protein MreB Mrl
C0971_RS06780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0971_RS06785	COG1923	regulation of RNA biosynthetic process
C0971_RS06790	COG0464	growth
C0971_RS06795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0971_RS06800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C0971_RS06805	COG0789	Transcriptional regulator
C0971_RS06810	COG0174	glutamine synthetase
C0971_RS06840	COG2124	cytochrome p450
C0971_RS06845	COG1611	Belongs to the LOG family
C0971_RS06855	COG1247	-acetyltransferase
C0971_RS06890	COG2323	membrane
C0971_RS06895	COG4451	ribulose bisphosphate carboxylase, small
C0971_RS06895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0971_RS06920	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0971_RS06925	COG2323	membrane
C0971_RS06935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0971_RS06945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0971_RS06950	COG4224	UPF0291 protein
C0971_RS06965	COG3763	UPF0154 protein
C0971_RS06980	COG1132	(ABC) transporter
C0971_RS06985	COG1132	(ABC) transporter
C0971_RS06995	COG0785	Cytochrome C biogenesis protein
C0971_RS07000	COG2201	protein-glutamate methylesterase activity
C0971_RS07005	COG4846	Membrane protein involved in cytochrome C biogenesis
C0971_RS07035	COG0420	3'-5' exonuclease activity
C0971_RS07040	COG0419	ATPase involved in DNA repair
C0971_RS07055	COG5146	pantothenate kinase activity
C0971_RS07065	COG0702	epimerase
C0971_RS07070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_RS07075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0971_RS07080	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C0971_RS07085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0971_RS07110	COG3344	reverse transcriptase
C0971_RS07115	COG0604	alcohol dehydrogenase
C0971_RS07140	COG1247	-acetyltransferase
C0971_RS07150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_RS07155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0971_RS07165	COG0791	NLP P60 protein
C0971_RS07165	COG1388	LysM domain
C0971_RS07180	COG1088	dTDP-glucose 4,6-dehydratase activity
C0971_RS07190	COG1086	Polysaccharide biosynthesis protein
C0971_RS07195	COG0463	Glycosyl transferase, family 2
C0971_RS07195	COG1216	Glycosyl transferase, family 2
C0971_RS07245	COG0438	transferase activity, transferring glycosyl groups
C0971_RS07310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0971_RS07320	COG2223	nitrite transmembrane transporter activity
C0971_RS07325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_RS07330	COG0243	molybdopterin cofactor binding
C0971_RS07335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_RS07340	COG2146	nitrite reductase [NAD(P)H] activity
C0971_RS07360	COG0156	8-amino-7-oxononanoate synthase activity
C0971_RS07365	COG2267	carboxylic ester hydrolase activity
C0971_RS07430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0971_RS07460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_RS07495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0971_RS07500	COG1116	anion transmembrane transporter activity
C0971_RS07505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS07510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_RS07540	COG1294	oxidase, subunit
C0971_RS07555	COG3118	belongs to the thioredoxin family
C0971_RS07560	COG0730	response to heat
C0971_RS07570	COG0425	Belongs to the sulfur carrier protein TusA family
C0971_RS07570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_RS07575	COG2210	Belongs to the sulfur carrier protein TusA family
C0971_RS07580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_RS07580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_RS07585	COG0425	Belongs to the sulfur carrier protein TusA family
C0971_RS07590	COG2210	Belongs to the sulfur carrier protein TusA family
C0971_RS07595	COG1937	Protein conserved in bacteria
C0971_RS07600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_RS07630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0971_RS07635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0971_RS07650	COG2267	carboxylic ester hydrolase activity
C0971_RS07685	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C0971_RS07685	COG1605	Chorismate mutase
C0971_RS07720	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C0971_RS07725	COG2267	carboxylic ester hydrolase activity
C0971_RS07795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS07800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS07805	COG3414	Phosphotransferase system galactitol-specific IIB component
C0971_RS07810	COG3775	system Galactitol-specific IIC component
C0971_RS07815	COG1063	alcohol dehydrogenase
C0971_RS07825	COG1063	alcohol dehydrogenase
C0971_RS07830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C0971_RS07835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_RS07860	COG0824	Thioesterase
C0971_RS07870	COG4841	protein insertion into membrane
C0971_RS07900	COG1136	(ABC) transporter
C0971_RS07905	COG0577	efflux transmembrane transporter activity
C0971_RS07905	COG1136	(ABC) transporter
C0971_RS07915	COG0745	RESPONSE REGULATOR receiver
C0971_RS07920	COG5002	protein histidine kinase activity
C0971_RS07960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0971_RS07960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0971_RS07965	COG3973	AAA domain
C0971_RS07970	COG0477	Major facilitator Superfamily
C0971_RS07975	COG5002	protein histidine kinase activity
C0971_RS07980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0971_RS08000	COG1832	CoA-binding protein
C0971_RS08005	COG0187	DNA topoisomerase II activity
C0971_RS08010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0971_RS08060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0971_RS08065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0971_RS08090	COG0456	acetyltransferase
C0971_RS08095	COG0697	spore germination
C0971_RS08100	COG1819	glycosyl
C0971_RS08120	COG5002	protein histidine kinase activity
C0971_RS08135	COG0789	Transcriptional regulator
C0971_RS08140	COG2814	Major facilitator Superfamily
C0971_RS08155	COG0477	Major facilitator Superfamily
C0971_RS08160	COG0584	glycerophosphoryl diester phosphodiesterase
C0971_RS08170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_RS08175	COG1116	anion transmembrane transporter activity
C0971_RS08180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS08185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_RS08190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_RS08195	COG0196	riboflavin kinase activity
C0971_RS08200	COG0196	riboflavin kinase activity
C0971_RS08210	COG1960	acyl-CoA dehydrogenase activity
C0971_RS08225	COG2197	response regulator
C0971_RS08230	COG4585	Histidine kinase
C0971_RS08235	COG3239	Fatty acid desaturase
C0971_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_RS08250	COG0483	inositol monophosphate 1-phosphatase activity
C0971_RS08255	COG1757	Na H antiporter
C0971_RS08260	COG0693	protein deglycase activity
C0971_RS08285	COG0531	amino acid
C0971_RS08295	COG3663	DNA glycosylase
C0971_RS08300	COG0477	Major facilitator Superfamily
C0971_RS08305	COG1846	Transcriptional regulator
C0971_RS08310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_RS08320	COG0531	amino acid
C0971_RS08325	COG0531	amino acid
C0971_RS08330	COG5577	PFAM Coat F domain
C0971_RS08335	COG3647	Membrane
C0971_RS08345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0971_RS08355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0971_RS08375	COG1119	ATPase activity
C0971_RS08385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_RS08390	COG2720	vancomycin resistance protein
C0971_RS08395	COG1418	mRNA catabolic process
C0971_RS08405	COG1664	Polymer-forming cytoskeletal
C0971_RS08410	COG1664	Polymer-forming cytoskeletal
C0971_RS08415	COG0789	Transcriptional regulator
C0971_RS08420	COG1714	RDD family
C0971_RS08435	COG3584	3D domain protein
C0971_RS08435	COG1388	LysM domain
C0971_RS08465	COG2814	Major facilitator Superfamily
C0971_RS08470	COG0303	'Molybdopterin
C0971_RS08475	COG2068	MobA-Related Protein
C0971_RS08480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0971_RS08505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0971_RS08505	COG3608	succinylglutamate desuccinylase aspartoacylase
C0971_RS08525	COG1346	cytolysis
C0971_RS08530	COG1380	Effector of murein hydrolase LrgA
C0971_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS08545	COG0488	(ABC) transporter
C0971_RS08560	COG4149	molybdate abc transporter
C0971_RS08565	COG1388	LysM domain
C0971_RS08565	COG0791	NLP P60 protein
C0971_RS08575	COG0697	spore germination
C0971_RS08590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0971_RS08595	COG1268	BioY protein
C0971_RS08605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0971_RS08610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0971_RS08620	COG1253	flavin adenine dinucleotide binding
C0971_RS08665	COG0432	Pfam Uncharacterised protein family UPF0047
C0971_RS08680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_RS08685	COG0567	Dehydrogenase, E1 component
C0971_RS08695	COG1960	acyl-CoA dehydrogenase activity
C0971_RS08710	COG2323	membrane
C0971_RS08720	COG1309	transcriptional regulator
C0971_RS08725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_RS08745	COG0681	Belongs to the peptidase S26 family
C0971_RS08755	COG4637	Psort location Cytoplasmic, score
C0971_RS08760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0971_RS08770	COG0456	acetyltransferase
C0971_RS08780	COG1525	nuclease
C0971_RS08805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS08820	COG0626	cystathionine gamma-synthase activity
C0971_RS08825	COG0626	cystathionine gamma-synthase activity
C0971_RS08830	COG0646	methionine synthase
C0971_RS08830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0971_RS08835	COG0646	methionine synthase
C0971_RS08835	COG1410	methionine synthase
C0971_RS08840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_RS08845	COG1607	acyl-coa hydrolase
C0971_RS08855	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0971_RS08860	COG2267	carboxylic ester hydrolase activity
C0971_RS08870	COG0768	penicillin binding
C0971_RS08880	COG1131	(ABC) transporter
C0971_RS08885	COG1725	Transcriptional regulator
C0971_RS08890	COG0697	spore germination
C0971_RS08900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0971_RS08910	COG0586	Pfam SNARE associated Golgi protein
C0971_RS08925	COG3383	formate dehydrogenase (NAD+) activity
C0971_RS08930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0971_RS08935	COG1464	Belongs to the NlpA lipoprotein family
C0971_RS08940	COG2011	ABC-type metal ion transport system permease component
C0971_RS08945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0971_RS08950	COG0778	Nitroreductase
C0971_RS08955	COG0535	radical SAM domain protein
C0971_RS08960	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0971_RS08970	COG0494	nUDIX hydrolase
C0971_RS08995	COG1842	Phage shock protein A
C0971_RS09005	COG4608	Belongs to the ABC transporter superfamily
C0971_RS09010	COG0791	NLP P60 protein
C0971_RS09015	COG4948	Mandelate Racemase Muconate Lactonizing
C0971_RS09020	COG1619	proteins homologs of microcin C7 resistance protein MccF
C0971_RS09025	COG4166	transmembrane transport
C0971_RS09030	COG0444	Belongs to the ABC transporter superfamily
C0971_RS09035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0971_RS09040	COG0601	transmembrane transport
C0971_RS09045	COG2362	D-Aminopeptidase
C0971_RS09050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0971_RS09055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0971_RS09060	COG0527	aspartate kinase activity
C0971_RS09075	COG2861	carbohydrate metabolic process
C0971_RS09090	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0971_RS09110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0971_RS09115	COG0672	)-iron permease
C0971_RS09120	COG2837	iron assimilation
C0971_RS09125	COG2822	iron ion transport
C0971_RS09130	COG0778	Nitroreductase
C0971_RS09135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0971_RS09140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0971_RS09150	COG0561	phosphatase activity
C0971_RS09155	COG0140	phosphoribosyl-ATP diphosphatase activity
C0971_RS09155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0971_RS09160	COG0284	orotidine-5'-phosphate decarboxylase activity
C0971_RS09170	COG4948	Mandelate Racemase Muconate Lactonizing
C0971_RS09180	COG1473	amidohydrolase
C0971_RS09190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_RS09215	COG1657	PFAM Prenyltransferase squalene oxidase
C0971_RS09220	COG3300	MHYT domain
C0971_RS09220	COG5001	Diguanylate cyclase
C0971_RS09230	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C0971_RS09235	COG0431	NADPH-dependent FMN reductase
C0971_RS09240	COG5583	Uncharacterized small protein (DUF2292)
C0971_RS09265	COG0840	transmembrane signaling receptor activity
C0971_RS09275	COG0720	synthase
C0971_RS09285	COG0243	molybdopterin cofactor binding
C0971_RS09295	COG2132	Multicopper oxidase
C0971_RS09300	COG0133	tryptophan synthase activity
C0971_RS09305	COG0791	NLP P60 protein
C0971_RS09305	COG3883	PFAM NLP P60 protein
C0971_RS09320	COG1061	Type III restriction enzyme res subunit
C0971_RS09355	COG0494	nUDIX hydrolase
C0971_RS09370	COG2766	serine protein kinase
C0971_RS09375	COG2718	Belongs to the UPF0229 family
C0971_RS09380	COG2719	SpoVR family
C0971_RS09415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0971_RS09430	COG0531	amino acid
C0971_RS09435	COG1113	amino acid transport
C0971_RS09450	COG5646	InterPro IPR014922
C0971_RS09455	COG5646	InterPro IPR014922
C0971_RS09465	COG0475	glutathione-regulated potassium exporter activity
C0971_RS09480	COG0672	)-iron permease
C0971_RS09485	COG2217	Heavy metal translocating P-type atpase
C0971_RS09490	COG2608	mercury ion transmembrane transporter activity
C0971_RS09505	COG0004	ammonium transporteR
C0971_RS09515	COG1742	UPF0060 membrane protein
C0971_RS09520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_RS09525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_RS09530	COG0716	FMN binding
C0971_RS09540	COG2318	DinB family
C0971_RS09570	COG0475	glutathione-regulated potassium exporter activity
C0971_RS09585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C0971_RS09585	COG0456	acetyltransferase
C0971_RS09610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_RS09640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS09645	COG2002	toxin-antitoxin pair type II binding
C0971_RS09655	COG0477	Major facilitator Superfamily
C0971_RS09660	COG0673	inositol 2-dehydrogenase activity
C0971_RS09670	COG0561	phosphatase activity
C0971_RS09675	COG0084	hydrolase, TatD family'
C0971_RS09685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS09695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_RS09700	COG1131	(ABC) transporter
C0971_RS09705	COG0842	Transport permease protein
C0971_RS09710	COG4585	Histidine kinase
C0971_RS09715	COG2197	response regulator
C0971_RS09735	COG1929	Belongs to the glycerate kinase type-1 family
C0971_RS09745	COG2080	2 iron, 2 sulfur cluster binding
C0971_RS09755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C0971_RS09765	COG1408	metallophosphoesterase
C0971_RS09770	COG0726	polysaccharide deacetylase
C0971_RS09805	COG2200	EAL domain
C0971_RS09805	COG2203	Gaf domain
C0971_RS09805	COG2199	diguanylate cyclase activity
C0971_RS09885	COG1388	LysM domain
C0971_RS09885	COG0791	NLP P60 protein
C0971_RS09890	COG5280	Phage tail tape measure protein TP901
C0971_RS09890	COG3953	SLT domain
C0971_RS09975	COG5484	DNA packaging
C0971_RS10015	COG2201	protein-glutamate methylesterase activity
C0971_RS10025	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C0971_RS10050	COG1484	DNA-dependent DNA replication
C0971_RS10065	COG3723	Recombinational DNA repair protein, rece pathway
C0971_RS10070	COG5377	YqaJ viral recombinase family
C0971_RS10115	COG1396	sequence-specific DNA binding
C0971_RS10145	COG0582	viral genome integration into host DNA
C0971_RS10175	COG0134	indole-3-glycerol-phosphate synthase activity
C0971_RS10180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0971_RS10185	COG0512	Glutamine amidotransferase of anthranilate synthase
C0971_RS10185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0971_RS10200	COG2814	Major facilitator Superfamily
C0971_RS10205	COG0596	Alpha beta hydrolase
C0971_RS10225	COG1131	(ABC) transporter
C0971_RS10230	COG1846	Transcriptional regulator
C0971_RS10235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0971_RS10235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0971_RS10235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS10240	COG1105	Belongs to the carbohydrate kinase PfkB family
C0971_RS10245	COG1349	DNA-binding transcription factor activity
C0971_RS10250	COG2259	Doxx family
C0971_RS10255	COG1959	2 iron, 2 sulfur cluster binding
C0971_RS10260	COG1331	Highly conserved protein containing a thioredoxin domain
C0971_RS10265	COG1331	Highly conserved protein containing a thioredoxin domain
C0971_RS10270	COG0456	acetyltransferase
C0971_RS10275	COG1279	arginine transmembrane transporter activity
C0971_RS10280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_RS10290	COG0805	protein transport
C0971_RS10335	COG2814	Major facilitator Superfamily
C0971_RS10345	COG0659	secondary active sulfate transmembrane transporter activity
C0971_RS10360	COG4191	Histidine kinase
C0971_RS10385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0971_RS10390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C0971_RS10420	COG0586	Pfam SNARE associated Golgi protein
C0971_RS10425	COG1376	ErfK ybiS ycfS ynhG family protein
C0971_RS10430	COG1793	dna ligase
C0971_RS10430	COG3285	dna ligase
C0971_RS10450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0971_RS10455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0971_RS10455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0971_RS10460	COG0307	riboflavin synthase, alpha
C0971_RS10465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0971_RS10465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0971_RS10475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_RS10510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0971_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_RS10535	COG2340	Cysteine-rich secretory protein family
C0971_RS10590	COG5002	protein histidine kinase activity
C0971_RS10595	COG0745	RESPONSE REGULATOR receiver
C0971_RS10630	COG1316	TRANSCRIPTIONal
C0971_RS10635	COG0793	Belongs to the peptidase S41A family
C0971_RS10635	COG3409	Peptidoglycan-binding domain 1 protein
C0971_RS10640	COG1876	peptidase activity
C0971_RS10660	COG4326	sporulation control protein
C0971_RS10680	COG4479	Belongs to the UPF0346 family
C0971_RS10690	COG1509	lysine 2,3-aminomutase activity
C0971_RS10695	COG3829	transcription factor binding
C0971_RS10700	COG0456	acetyltransferase
C0971_RS10705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0971_RS10710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0971_RS10715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0971_RS10720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_RS10750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0971_RS10760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0971_RS10760	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C0971_RS10770	COG2755	lipolytic protein G-D-S-L family
C0971_RS10775	COG1999	signal sequence binding
C0971_RS10785	COG0805	protein transport
C0971_RS10790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0971_RS10795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0971_RS10800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0971_RS10815	COG0861	Integral membrane protein TerC family
C0971_RS10825	COG2136	Putative SAM-dependent methyltransferase
C0971_RS10825	COG2521	methyltransferase
C0971_RS10835	COG0129	dihydroxy-acid dehydratase activity
C0971_RS10840	COG1413	lyase activity
C0971_RS10845	COG0488	(ABC) transporter
C0971_RS10850	COG1418	mRNA catabolic process
C0971_RS10855	COG1307	EDD domain protein, DegV family
C0971_RS10885	COG1321	iron dependent repressor
C0971_RS10895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0971_RS10900	COG0277	FAD linked oxidase domain protein
C0971_RS10930	COG0328	RNA-DNA hybrid ribonuclease activity
C0971_RS10950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_RS10960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0971_RS10980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C0971_RS10985	COG1755	Isoprenylcysteine carboxyl methyltransferase
C0971_RS10990	COG3424	synthase
C0971_RS11000	COG2233	PERMEase
C0971_RS11005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_RS11015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0971_RS11020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0971_RS11025	COG0697	spore germination
C0971_RS11030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C0971_RS11035	COG1199	ATP-dependent helicase activity
C0971_RS11050	COG0116	Belongs to the methyltransferase superfamily
C0971_RS11055	COG5001	Diguanylate cyclase
C0971_RS11055	COG3300	MHYT domain
C0971_RS11075	COG3359	exonuclease
C0971_RS11080	COG1111	helicase
C0971_RS11080	COG1205	dead DEAH box helicase
C0971_RS11085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0971_RS11090	COG1151	hydroxylamine reductase activity
C0971_RS11125	COG3331	DNA recombination
C0971_RS11130	COG4499	WXG100 protein secretion system (Wss), protein YukC
C0971_RS11130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_RS11145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0971_RS11150	COG3935	DnaD domain protein
C0971_RS11155	COG0017	Asparaginyl-tRNA synthetase
C0971_RS11160	COG0436	Aminotransferase
C0971_RS11175	COG1199	ATP-dependent helicase activity
C0971_RS11175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0971_RS11180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C0971_RS11185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0971_RS11190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0971_RS11200	COG0617	tRNA 3'-terminal CCA addition
C0971_RS11205	COG0438	transferase activity, transferring glycosyl groups
C0971_RS11210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_RS11215	COG1803	Methylglyoxal synthase
C0971_RS11220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0971_RS11225	COG1694	Mazg nucleotide pyrophosphohydrolase
C0971_RS11230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_RS11235	COG2738	Putative neutral zinc metallopeptidase
C0971_RS11245	COG4347	Protein of unknown function (DUF1405)
C0971_RS11270	COG5582	Belongs to the UPF0302 family
C0971_RS11275	COG0457	Tetratricopeptide repeat
C0971_RS11285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0971_RS11290	COG0287	Prephenate dehydrogenase
C0971_RS11295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0971_RS11305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0971_RS11310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0971_RS11315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0971_RS11320	COG0105	UTP biosynthetic process
C0971_RS11325	COG0142	geranyltranstransferase activity
C0971_RS11330	COG2226	methyltransferase
C0971_RS11335	COG0142	geranyltranstransferase activity
C0971_RS11345	COG0302	gtp cyclohydrolase
C0971_RS11350	COG0776	regulation of translation
C0971_RS11360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C0971_RS11380	COG1160	GTP binding
C0971_RS11405	COG1304	FMN binding
C0971_RS11410	COG0539	negative regulation of cytoplasmic translation
C0971_RS11420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0971_RS11435	COG2959	enzyme of heme biosynthesis
C0971_RS11440	COG3773	Cell wall hydrolase
C0971_RS11440	COG3409	Peptidoglycan-binding domain 1 protein
C0971_RS11445	COG2339	peptidase activity
C0971_RS11455	COG0492	ferredoxin-NADP+ reductase activity
C0971_RS11460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0971_RS11465	COG4862	establishment of competence for transformation
C0971_RS11470	COG1408	metallophosphoesterase
C0971_RS11480	COG1388	LysM domain
C0971_RS11485	COG1266	CAAX protease self-immunity
C0971_RS11490	COG0514	ATP-dependent DNA helicase (RecQ)
C0971_RS11495	COG4955	Helix-turn-helix domain
C0971_RS11500	COG4955	Helix-turn-helix domain
C0971_RS11510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C0971_RS11515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0971_RS11520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_RS11525	COG0739	heme binding
C0971_RS11535	COG1595	DNA-templated transcription, initiation
C0971_RS11545	COG5002	protein histidine kinase activity
C0971_RS11550	COG0745	RESPONSE REGULATOR receiver
C0971_RS11555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0971_RS11560	COG1333	cytochrome c biogenesis protein
C0971_RS11570	COG1187	pseudouridine synthase activity
C0971_RS11575	COG0700	Nucleoside recognition
C0971_RS11580	COG2715	membrane protein required for spore maturation
C0971_RS11585	COG1686	Belongs to the peptidase S11 family
C0971_RS11590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0971_RS11600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0971_RS11605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0971_RS11615	COG1547	Domain of unknown function (DUF309)
C0971_RS11630	COG0697	spore germination
C0971_RS11650	COG2172	sigma factor antagonist activity
C0971_RS11660	COG1686	Belongs to the peptidase S11 family
C0971_RS11680	COG4974	Belongs to the 'phage' integrase family
C0971_RS11690	COG0735	belongs to the Fur family
C0971_RS11695	COG1300	Membrane
C0971_RS11700	COG1379	DNA repair
C0971_RS11710	COG0667	Aldo Keto reductase
C0971_RS11725	COG1959	2 iron, 2 sulfur cluster binding
C0971_RS11730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0971_RS11735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0971_RS11745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0971_RS11755	COG1073	alpha beta
C0971_RS11760	COG1294	oxidase, subunit
C0971_RS11765	COG1271	oxidase subunit
C0971_RS11770	COG4918	Iron-sulphur cluster biosynthesis
C0971_RS11780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0971_RS11790	COG0300	oxidoreductase activity
C0971_RS11795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_RS11800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0971_RS11805	COG1902	pentaerythritol trinitrate reductase activity
C0971_RS11810	COG1234	tRNA 3'-trailer cleavage
C0971_RS11815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0971_RS11820	COG4086	secreted protein
C0971_RS11825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0971_RS11830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0971_RS11835	COG0835	chemotaxis
C0971_RS11840	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0971_RS11845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0971_RS11850	COG0346	lactoylglutathione lyase activity
C0971_RS11860	COG1126	abc transporter atp-binding protein
C0971_RS11865	COG0765	amino acid transport
C0971_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_RS11890	COG1703	isobutyryl-CoA mutase activity
C0971_RS11895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_RS11895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_RS11905	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_RS11910	COG0022	dehydrogenase e1 component
C0971_RS11915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0971_RS11920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0971_RS11925	COG3426	butyrate kinase activity
C0971_RS11935	COG0280	phosphate acetyltransferase
C0971_RS11940	COG3290	protein histidine kinase activity
C0971_RS11940	COG3829	transcription factor binding
C0971_RS11950	COG0584	glycerophosphoryl diester phosphodiesterase
C0971_RS12020	COG0750	zinc metalloprotease
C0971_RS12025	COG0497	DNA recombination
C0971_RS12030	COG1438	arginine binding
C0971_RS12035	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C0971_RS12040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0971_RS12050	COG1722	exodeoxyribonuclease VII activity
C0971_RS12055	COG1570	exodeoxyribonuclease VII activity
C0971_RS12060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0971_RS12065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0971_RS12070	COG1302	Protein conserved in bacteria
C0971_RS12075	COG0439	Biotin carboxylase
C0971_RS12080	COG0511	ligase activity, forming carbon-carbon bonds
C0971_RS12120	COG3854	ATPases associated with a variety of cellular activities
C0971_RS12135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0971_RS12140	COG0006	proline dipeptidase activity
C0971_RS12145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0971_RS12155	COG3872	metal-dependent enzyme
C0971_RS12165	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0971_RS12170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_RS12180	COG3344	reverse transcriptase
C0971_RS12190	COG0095	Lipoate-protein ligase
C0971_RS12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_RS12210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0971_RS12215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0971_RS12220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_RS12260	COG4537	Required for transformation and DNA binding
C0971_RS12265	COG1459	type II secretion system
C0971_RS12270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0971_RS12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_RS12315	COG1368	sulfuric ester hydrolase activity
C0971_RS12320	COG1940	carbohydrate kinase activity
C0971_RS12335	COG0457	Tetratricopeptide repeat
C0971_RS12335	COG0705	Rhomboid family
C0971_RS12340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0971_RS12345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_RS12375	COG0704	Plays a role in the regulation of phosphate uptake
C0971_RS12385	COG0768	penicillin binding
C0971_RS12390	COG0477	Major facilitator Superfamily
C0971_RS12405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0971_RS12425	COG0248	Ppx GppA phosphatase
C0971_RS12435	COG2839	Protein conserved in bacteria
C0971_RS12440	COG5521	maltodextrose utilization protein MalA
C0971_RS12445	COG2814	Major facilitator Superfamily
C0971_RS12455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0971_RS12460	COG4709	membrane
C0971_RS12465	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C0971_RS12470	COG0735	belongs to the Fur family
C0971_RS12475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0971_RS12480	COG1121	(ABC) transporter
C0971_RS12485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_RS12495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C0971_RS12500	COG0513	Belongs to the DEAD box helicase family
C0971_RS12510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0971_RS12515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0971_RS12520	COG2384	SAM-dependent methyltransferase
C0971_RS12525	COG2010	Cytochrome c
C0971_RS12530	COG1960	acyl-CoA dehydrogenase activity
C0971_RS12535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0971_RS12540	COG0358	DNA primase activity
C0971_RS12545	COG1671	Belongs to the UPF0178 family
C0971_RS12550	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0971_RS12550	COG0392	lysyltransferase activity
C0971_RS12555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0971_RS12560	COG0517	IMP dehydrogenase activity
C0971_RS12565	COG0423	glycine-tRNA ligase activity
C0971_RS12570	COG1381	Involved in DNA repair and RecF pathway recombination
C0971_RS12590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0971_RS12600	COG1480	7TM receptor with intracellular HD hydrolase
C0971_RS12605	COG1702	phosphate starvation-inducible protein PhoH
C0971_RS12625	COG4864	UPF0365 protein
C0971_RS12630	COG1030	water channel activity
C0971_RS12635	COG1610	YqeY-like protein
C0971_RS12645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0971_RS12650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0971_RS12655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0971_RS12660	COG2264	protein methyltransferase activity
C0971_RS12670	COG0443	Heat shock 70 kDa protein
C0971_RS12680	COG1420	regulation of RNA biosynthetic process
C0971_RS12685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0971_RS12690	COG0481	GTPase activity
C0971_RS12700	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_RS12710	COG0268	Binds directly to 16S ribosomal RNA
C0971_RS12715	COG1466	dna polymerase III delta subunit
C0971_RS12725	COG0658	competence protein
C0971_RS12725	COG2333	competence protein COMEC
C0971_RS12730	COG2131	deaminase
C0971_RS12735	COG1555	photosystem II stabilization
C0971_RS12735	COG1596	polysaccharide export
C0971_RS12740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0971_RS12745	COG2226	methyltransferase
C0971_RS12750	COG0799	negative regulation of ribosome biogenesis
C0971_RS12755	COG1713	HD superfamily hydrolase involved in NAD metabolism
C0971_RS12760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0971_RS12765	COG1534	Rna-binding protein
C0971_RS12775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0971_RS12780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C0971_RS12790	COG0688	phosphatidylethanolamine metabolic process
C0971_RS12810	COG0626	cystathionine gamma-synthase activity
C0971_RS12815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_RS12820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0971_RS12825	COG2226	methyltransferase
C0971_RS12840	COG0768	penicillin binding
C0971_RS12850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0971_RS12855	COG0572	uridine kinase
C0971_RS12860	COG0826	peptidase U32
C0971_RS12865	COG0826	peptidase U32
C0971_RS12870	COG4122	O-methyltransferase activity
C0971_RS12875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0971_RS12880	COG3906	Belongs to the UPF0473 family
C0971_RS12890	COG4472	Bacterial protein of unknown function (DUF965)
C0971_RS12895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0971_RS12900	COG0628	permease
C0971_RS12915	COG3881	PFAM PRC-barrel domain
C0971_RS12920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0971_RS12930	COG0482	sulfurtransferase activity
C0971_RS12935	COG1104	cysteine desulfurase activity
C0971_RS12940	COG1959	2 iron, 2 sulfur cluster binding
C0971_RS12945	COG2364	Membrane
C0971_RS12950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0971_RS12960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0971_RS12965	COG0124	histidyl-tRNA synthetase
C0971_RS12975	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_RS12975	COG3103	Sh3 type 3 domain protein
C0971_RS12975	COG4991	sh3 domain protein
C0971_RS12980	COG1490	D-aminoacyl-tRNA deacylase activity
C0971_RS12985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0971_RS12990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_RS12995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0971_RS12995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C0971_RS13000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0971_RS13005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0971_RS13005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0971_RS13015	COG2244	polysaccharide biosynthetic process
C0971_RS13020	COG2323	membrane
C0971_RS13030	COG1309	transcriptional regulator
C0971_RS13035	COG2814	Major facilitator Superfamily
C0971_RS13040	COG2814	Major facilitator Superfamily
C0971_RS13045	COG1862	Preprotein translocase
C0971_RS13055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0971_RS13070	COG0632	four-way junction helicase activity
C0971_RS13080	COG0217	transcriptional regulatory protein
C0971_RS13100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0971_RS13105	COG0157	Belongs to the NadC ModD family
C0971_RS13110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0971_RS13115	COG1104	cysteine desulfurase activity
C0971_RS13120	COG0077	Prephenate dehydratase
C0971_RS13125	COG4492	Belongs to the UPF0735 family
C0971_RS13130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0971_RS13135	COG3290	protein histidine kinase activity
C0971_RS13140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0971_RS13145	COG2868	ribosomal protein
C0971_RS13150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0971_RS13160	COG1994	Peptidase M50
C0971_RS13165	COG0739	heme binding
C0971_RS13170	COG2894	cell division
C0971_RS13175	COG0850	regulation of cytokinetic process
C0971_RS13185	COG1792	Involved in formation and maintenance of cell shape
C0971_RS13190	COG1077	Cell shape determining protein MreB Mrl
C0971_RS13195	COG2003	Belongs to the UPF0758 family
C0971_RS13235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0971_RS13255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0971_RS13280	COG0285	dihydrofolate synthase activity
C0971_RS13285	COG0525	valine-tRNA ligase activity
C0971_RS13295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_RS13300	COG1388	LysM domain
C0971_RS13300	COG1388	LysM domain
C0971_RS13305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0971_RS13310	COG0113	porphobilinogen synthase activity
C0971_RS13315	COG1587	Uroporphyrinogen-III synthase
C0971_RS13320	COG0181	hydroxymethylbilane synthase activity
C0971_RS13325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0971_RS13340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0971_RS13345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0971_RS13350	COG0470	DNA polymerase III
C0971_RS13350	COG1067	ATP-dependent peptidase activity
C0971_RS13355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0971_RS13360	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0971_RS13365	COG1477	protein flavinylation
C0971_RS13365	COG0457	Tetratricopeptide repeat
C0971_RS13370	COG0066	3-isopropylmalate dehydratase activity
C0971_RS13375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0971_RS13380	COG0473	3-isopropylmalate dehydrogenase activity
C0971_RS13385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0971_RS13390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0971_RS13395	COG0440	acetolactate synthase activity
C0971_RS13400	COG0028	Belongs to the TPP enzyme family
C0971_RS13405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_RS13420	COG0622	Phosphoesterase
C0971_RS13430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0971_RS13435	COG5401	PFAM Sporulation and spore germination
C0971_RS13445	COG1846	Transcriptional regulator
C0971_RS13450	COG2031	fatty acid transporter
C0971_RS13455	COG2197	response regulator
C0971_RS13460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0971_RS13465	COG1053	succinate dehydrogenase
C0971_RS13470	COG2009	succinate dehydrogenase
C0971_RS13475	COG1719	4-vinyl reductase, 4VR
C0971_RS13485	COG0322	excinuclease ABC activity
C0971_RS13490	COG3118	belongs to the thioredoxin family
C0971_RS13495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C0971_RS13500	COG2086	electron transfer activity
C0971_RS13505	COG1024	Enoyl-CoA hydratase
C0971_RS13510	COG1309	transcriptional regulator
C0971_RS13515	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_RS13520	COG3766	membrane
C0971_RS13525	COG1193	negative regulation of DNA recombination
C0971_RS13530	COG1796	DNA polymerase
C0971_RS13530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_RS13535	COG1286	toxin biosynthetic process
C0971_RS13540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C0971_RS13545	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0971_RS13550	COG0072	phenylalanine-tRNA ligase activity
C0971_RS13550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0971_RS13555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0971_RS13560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0971_RS13570	COG1363	Peptidase, m42
C0971_RS13590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0971_RS13595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0971_RS13600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0971_RS13605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0971_RS13615	COG1484	DNA-dependent DNA replication
C0971_RS13620	COG3611	Membrane attachment protein
C0971_RS13625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0971_RS13630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C0971_RS13635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0971_RS13640	COG0237	dephospho-CoA kinase activity
C0971_RS13645	COG1971	Probably functions as a manganese efflux pump
C0971_RS13650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0971_RS13655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_RS13655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_RS13675	COG5002	protein histidine kinase activity
C0971_RS13680	COG0745	RESPONSE REGULATOR receiver
C0971_RS13685	COG0039	L-malate dehydrogenase activity
C0971_RS13690	COG0538	isocitrate dehydrogenase activity
C0971_RS13695	COG0372	Belongs to the citrate synthase family
C0971_RS13700	COG2707	UPF0756 membrane protein
C0971_RS13705	COG0628	permease
C0971_RS13710	COG3030	protein affecting phage T7 exclusion by the F plasmid
C0971_RS13725	COG0825	malonyl-CoA metabolic process
C0971_RS13730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0971_RS13735	COG1725	Transcriptional regulator
C0971_RS13740	COG0281	malic enzyme
C0971_RS13745	COG0587	DNA-directed DNA polymerase activity
C0971_RS13760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0971_RS13770	COG4109	DRTGG domain
C0971_RS13780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0971_RS13785	COG0006	proline dipeptidase activity
C0971_RS13800	COG0165	Argininosuccinate lyase
C0971_RS13805	COG0137	argininosuccinate synthase activity
C0971_RS13815	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0971_RS13825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0971_RS13830	COG0827	DNA restriction-modification system
C0971_RS13835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C0971_RS13840	COG3874	Sporulation protein YtfJ
C0971_RS13850	COG1714	RDD family
C0971_RS13855	COG0616	signal peptide processing
C0971_RS13860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0971_RS13865	COG2962	Rard protein
C0971_RS13870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_RS13880	COG0301	tRNA thio-modification
C0971_RS13885	COG1104	cysteine desulfurase activity
C0971_RS13890	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C0971_RS13895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_RS13900	COG1309	transcriptional regulator
C0971_RS13905	COG1956	GAF domain-containing protein
C0971_RS13910	COG2199	diguanylate cyclase activity
C0971_RS13910	COG2203	Gaf domain
C0971_RS13915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0971_RS13920	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS13935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_RS13945	COG0454	-acetyltransferase
C0971_RS13950	COG0517	IMP dehydrogenase activity
C0971_RS13955	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0971_RS13965	COG1605	Chorismate mutase
C0971_RS13965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C0971_RS13975	COG4980	gas vesicle protein
C0971_RS13985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0971_RS13990	COG1674	ftsk spoiiie
C0971_RS13990	COG1674	ftsk spoiiie
C0971_RS13995	COG4848	Belongs to the UPF0354 family
C0971_RS14000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_RS14005	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C0971_RS14010	COG1363	Peptidase, m42
C0971_RS14020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0971_RS14030	COG0510	thiamine kinase activity
C0971_RS14035	COG1523	belongs to the glycosyl hydrolase 13 family
C0971_RS14050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_RS14055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0971_RS14065	COG1131	(ABC) transporter
C0971_RS14075	COG1349	DNA-binding transcription factor activity
C0971_RS14080	COG1187	pseudouridine synthase activity
C0971_RS14090	COG2244	polysaccharide biosynthetic process
C0971_RS14095	COG2081	HI0933 family
C0971_RS14105	COG3162	membrane
C0971_RS14110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0971_RS14120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_RS14130	COG0495	leucyl-tRNA aminoacylation
C0971_RS14135	COG2814	Major facilitator Superfamily
C0971_RS14150	COG1242	4 iron, 4 sulfur cluster binding
C0971_RS14155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C0971_RS14165	COG2267	carboxylic ester hydrolase activity
C0971_RS14170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0971_RS14175	COG4990	cell redox homeostasis
C0971_RS14180	COG0367	asparagine synthase
C0971_RS14185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0971_RS14205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_RS14210	COG1116	anion transmembrane transporter activity
C0971_RS14215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS14220	COG0494	nUDIX hydrolase
C0971_RS14235	COG1937	Protein conserved in bacteria
C0971_RS14250	COG0640	Transcriptional regulator
C0971_RS14265	COG3546	catalase activity
C0971_RS14270	COG1854	S-ribosylhomocysteine lyase activity
C0971_RS14275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0971_RS14280	COG0288	reversible hydration of carbon dioxide
C0971_RS14290	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_RS14295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0971_RS14300	COG0596	Alpha beta hydrolase
C0971_RS14305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0971_RS14310	COG1169	isochorismate synthase
C0971_RS14315	COG1575	Belongs to the MenA family. Type 1 subfamily
C0971_RS14320	COG0058	SHG alpha-glucan phosphorylase activity
C0971_RS14325	COG0297	glycogen (starch) synthase activity
C0971_RS14330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0971_RS14335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0971_RS14480	COG1285	pathogenesis
C0971_RS14490	COG1733	regulation of RNA biosynthetic process
C0971_RS14515	COG3832	glyoxalase III activity
C0971_RS14520	COG0640	Transcriptional regulator
C0971_RS14525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C0971_RS14565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0971_RS14605	COG0004	ammonium transporteR
C0971_RS14615	COG2076	Multidrug Resistance protein
C0971_RS14625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_RS14630	COG0671	phosphoesterase, PA-phosphatase related
C0971_RS14635	COG0586	Pfam SNARE associated Golgi protein
C0971_RS14640	COG0745	RESPONSE REGULATOR receiver
C0971_RS14645	COG3850	Histidine kinase
C0971_RS14645	COG5002	protein histidine kinase activity
C0971_RS14660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0971_RS14670	COG2124	cytochrome p450
C0971_RS14675	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0971_RS14710	COG3883	PFAM NLP P60 protein
C0971_RS14710	COG0791	NLP P60 protein
C0971_RS14765	COG0456	acetyltransferase
C0971_RS14770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0971_RS14770	COG3153	acetyltransferase
C0971_RS14775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0971_RS14790	COG1979	alcohol dehydrogenase
C0971_RS14795	COG2155	Conserved Protein
C0971_RS14800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0971_RS14805	COG1098	S1 RNA binding domain
C0971_RS14810	COG0436	Aminotransferase
C0971_RS14815	COG1522	sequence-specific DNA binding
C0971_RS14820	COG2267	carboxylic ester hydrolase activity
C0971_RS14825	COG0861	Integral membrane protein TerC family
C0971_RS14830	COG2032	superoxide dismutase activity
C0971_RS14840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0971_RS14850	COG2050	protein possibly involved in aromatic compounds catabolism
C0971_RS14855	COG0586	Pfam SNARE associated Golgi protein
C0971_RS14870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0971_RS14880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C0971_RS14890	COG3584	3D domain protein
C0971_RS14900	COG0494	nUDIX hydrolase
C0971_RS14905	COG1252	NADH dehydrogenase
C0971_RS14915	COG0316	Belongs to the HesB IscA family
C0971_RS14925	COG4844	belongs to the
C0971_RS14930	COG1252	NADH dehydrogenase
C0971_RS14945	COG4837	Protein of unknown function (DUF1462)
C0971_RS14960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0971_RS14965	COG0460	homoserine dehydrogenase
C0971_RS14970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_RS14975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0971_RS14980	COG0647	UMP catabolic process
C0971_RS14985	COG2445	Protein of unknown function DUF86
C0971_RS14990	COG2199	diguanylate cyclase activity
C0971_RS14990	COG3287	FIST C domain
C0971_RS14990	COG2200	EAL domain
C0971_RS15005	COG4470	Protein conserved in bacteria
C0971_RS15015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0971_RS15020	COG0739	heme binding
C0971_RS15060	COG0737	Belongs to the 5'-nucleotidase family
C0971_RS15065	COG1801	Protein of unknown function DUF72
C0971_RS15070	COG0719	Fe-S assembly protein
C0971_RS15075	COG0822	iron-sulfur transferase activity
C0971_RS15080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0971_RS15085	COG0719	Fe-S assembly protein
C0971_RS15090	COG0396	ATPase activity
C0971_RS15100	COG1464	Belongs to the NlpA lipoprotein family
C0971_RS15105	COG2011	ABC-type metal ion transport system permease component
C0971_RS15110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0971_RS15115	COG2873	o-acetylhomoserine
C0971_RS15120	COG3118	belongs to the thioredoxin family
C0971_RS15125	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C0971_RS15130	COG0509	glycine decarboxylation via glycine cleavage system
C0971_RS15135	COG1393	Belongs to the ArsC family
C0971_RS15140	COG1960	acyl-CoA dehydrogenase activity
C0971_RS15145	COG0183	Belongs to the thiolase family
C0971_RS15150	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0971_RS15150	COG1024	Enoyl-CoA hydratase
C0971_RS15170	COG3361	conserved protein (COG2071)
C0971_RS15180	COG1120	ATPase activity
C0971_RS15185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_RS15190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0971_RS15215	COG0772	Belongs to the SEDS family
C0971_RS15220	COG0656	L-ascorbic acid biosynthetic process
C0971_RS15230	COG3764	Sortase (surface protein transpeptidase)
C0971_RS15235	COG0702	epimerase
C0971_RS15260	COG0598	Magnesium transport protein CorA
C0971_RS15270	COG2172	sigma factor antagonist activity
C0971_RS15275	COG4191	Histidine kinase
C0971_RS15280	COG0789	Transcriptional regulator
C0971_RS15285	COG2514	catechol 2,3-dioxygenase activity
C0971_RS15290	COG1227	inorganic diphosphatase activity
C0971_RS15300	COG1959	2 iron, 2 sulfur cluster binding
C0971_RS15305	COG0482	sulfurtransferase activity
C0971_RS15315	COG2814	Major facilitator Superfamily
C0971_RS15320	COG0583	DNA-binding transcription factor activity
C0971_RS15325	COG1511	domain protein
C0971_RS15330	COG0531	amino acid
C0971_RS15345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C0971_RS15350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C0971_RS15360	COG2205	protein histidine kinase activity
C0971_RS15370	COG0210	DNA helicase
C0971_RS15465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0971_RS15470	COG0557	exoribonuclease II activity
C0971_RS15475	COG1647	Serine aminopeptidase, S33
C0971_RS15480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0971_RS15485	COG0148	phosphopyruvate hydratase activity
C0971_RS15490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0971_RS15495	COG0149	triose-phosphate isomerase activity
C0971_RS15500	COG0126	phosphoglycerate kinase activity
C0971_RS15505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0971_RS15520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C0971_RS15605	COG3953	SLT domain
C0971_RS15605	COG5280	Phage tail tape measure protein TP901
C0971_RS15655	COG0740	serine-type endopeptidase activity
C0971_RS15745	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C0971_RS15785	COG1484	DNA-dependent DNA replication
C0971_RS15790	COG3935	DnaD domain protein
C0971_RS15800	COG3723	Recombinational DNA repair protein, rece pathway
C0971_RS15805	COG5377	YqaJ viral recombinase family
C0971_RS15840	COG1396	sequence-specific DNA binding
C0971_RS15870	COG0740	serine-type endopeptidase activity
C0971_RS15875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_RS15880	COG1481	regulation of sporulation
C0971_RS15885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C0971_RS15890	COG1660	Displays ATPase and GTPase activities
C0971_RS15895	COG1051	belongs to the nudix hydrolase family
C0971_RS15900	COG0492	ferredoxin-NADP+ reductase activity
C0971_RS15905	COG0457	Tetratricopeptide repeat
C0971_RS15910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0971_RS15910	COG0140	phosphoribosyl-ATP diphosphatase activity
C0971_RS15915	COG0107	imidazoleglycerol-phosphate synthase activity
C0971_RS15920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0971_RS15925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0971_RS15930	COG0131	Imidazoleglycerol-phosphate dehydratase
C0971_RS15935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0971_RS15940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0971_RS15945	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C0971_RS15950	COG0110	maltose O-acetyltransferase activity
C0971_RS15960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C0971_RS15970	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C0971_RS15975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0971_RS15980	COG0363	glucosamine-6-phosphate deaminase activity
C0971_RS15990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C0971_RS15995	COG1950	PFAM Membrane protein of
C0971_RS16000	COG3595	metallopeptidase activity
C0971_RS16005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0971_RS16010	COG0556	nucleotide-excision repair
C0971_RS16015	COG4897	Protein conserved in bacteria
C0971_RS16020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_RS16025	COG1309	transcriptional regulator
C0971_RS16040	COG2318	DinB family
C0971_RS16050	COG0531	amino acid
C0971_RS16055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_RS16060	COG0793	Belongs to the peptidase S41A family
C0971_RS16060	COG3409	Peptidoglycan-binding domain 1 protein
C0971_RS16065	COG1733	regulation of RNA biosynthetic process
C0971_RS16075	COG3883	PFAM NLP P60 protein
C0971_RS16075	COG0791	NLP P60 protein
C0971_RS16080	COG2177	Part of the ABC transporter FtsEX involved in
C0971_RS16085	COG2884	Cell division ATP-binding protein ftsE
C0971_RS16095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_RS16105	COG0653	protein targeting
C0971_RS16110	COG3012	SEC-C Motif Domain Protein
C0971_RS16110	COG1405	negative regulation of cell septum assembly
C0971_RS16115	COG2059	Chromate
C0971_RS16120	COG2059	Chromate
C0971_RS16135	COG1516	flagellar protein fliS
C0971_RS16140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C0971_RS16145	COG1334	flagellar protein FlaG
C0971_RS16175	COG4974	Belongs to the 'phage' integrase family
C0971_RS16210	COG0358	DNA primase activity
C0971_RS16250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C0971_RS16255	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C0971_RS16265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0971_RS16270	COG1256	bacterial-type flagellum assembly
C0971_RS16270	COG4786	Flagellar basal body rod
C0971_RS16290	COG1040	competence protein
C0971_RS16295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C0971_RS16305	COG1307	EDD domain protein, DegV family
C0971_RS16310	COG2197	response regulator
C0971_RS16315	COG4585	Histidine kinase
C0971_RS16320	COG1739	Uncharacterized protein family UPF0029
C0971_RS16325	COG1316	TRANSCRIPTIONal
C0971_RS16330	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_RS16340	COG2385	sporulation resulting in formation of a cellular spore
C0971_RS16340	COG2247	cell wall binding repeat
C0971_RS16345	COG0438	transferase activity, transferring glycosyl groups
C0971_RS16350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_RS16355	COG0438	transferase activity, transferring glycosyl groups
C0971_RS16380	COG2171	N-acyltransferase activity
C0971_RS16390	COG0673	inositol 2-dehydrogenase activity
C0971_RS16405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0971_RS16410	COG0653	protein targeting
C0971_RS16420	COG1388	LysM domain
C0971_RS16420	COG0791	NLP P60 protein
C0971_RS16435	COG2340	Cysteine-rich secretory protein family
C0971_RS16440	COG1696	Membrane protein involved in D-alanine export
C0971_RS16485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0971_RS16500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0971_RS16500	COG2199	diguanylate cyclase activity
C0971_RS16515	COG0840	transmembrane signaling receptor activity
C0971_RS16550	COG0431	NADPH-dependent FMN reductase
C0971_RS16560	COG2144	transferase activity, transferring acyl groups
C0971_RS16565	COG0438	transferase activity, transferring glycosyl groups
C0971_RS16585	COG2153	protein acetylation
C0971_RS16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_RS16610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_RS16615	COG4521	taurine ABC transporter
C0971_RS16625	COG1116	anion transmembrane transporter activity
C0971_RS16630	COG2175	clavaminate synthase activity
C0971_RS16635	COG2076	Multidrug Resistance protein
C0971_RS16655	COG0697	spore germination
C0971_RS16675	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C0971_RS16675	COG0662	Cupin 2, conserved barrel domain protein
C0971_RS16695	COG0830	nickel cation binding
C0971_RS16700	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C0971_RS16705	COG0804	urea catabolic process
C0971_RS16710	COG0832	Belongs to the urease beta subunit family
C0971_RS16715	COG0831	urea catabolic process
C0971_RS16725	COG0411	ABC transporter
C0971_RS16745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0971_RS16775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C0971_RS16800	COG0438	transferase activity, transferring glycosyl groups
C0971_RS16815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0971_RS16820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_RS16830	COG4464	protein tyrosine phosphatase activity
C0971_RS16835	COG0489	protein tyrosine kinase activity
C0971_RS16840	COG3944	biosynthesis protein
C0971_RS16865	COG1192	Involved in chromosome partitioning
C0971_RS16870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0971_RS16875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_RS16930	COG2247	cell wall binding repeat
C0971_RS16930	COG2385	sporulation resulting in formation of a cellular spore
C0971_RS16940	COG2207	Transcriptional regulator
C0971_RS16945	COG2814	Major facilitator Superfamily
C0971_RS16950	COG0656	L-ascorbic acid biosynthetic process
C0971_RS16975	COG0737	Belongs to the 5'-nucleotidase family
C0971_RS17010	COG4974	Belongs to the 'phage' integrase family
C0971_RS17015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0971_RS17040	COG4974	Belongs to the 'phage' integrase family
C0971_RS17080	COG0793	Belongs to the peptidase S41A family
C0971_RS17090	COG1388	LysM domain
C0971_RS17090	COG0791	NLP P60 protein
C0971_RS17100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_RS17120	COG1012	belongs to the aldehyde dehydrogenase family
C0971_RS17125	COG0861	Integral membrane protein TerC family
C0971_RS17135	COG0629	single-stranded DNA binding
C0971_RS17165	COG4786	Flagellar basal body rod
C0971_RS17170	COG4786	Flagellar basal body rod
C0971_RS17175	COG1077	Cell shape determining protein MreB Mrl
C0971_RS17180	COG1609	Transcriptional regulator
C0971_RS17185	COG0739	heme binding
C0971_RS17195	COG2048	Heterodisulfide reductase, subunit B
C0971_RS17200	COG4565	transcriptional regulatory protein
C0971_RS17205	COG4565	transcriptional regulatory protein
C0971_RS17210	COG3290	protein histidine kinase activity
C0971_RS17220	COG2385	sporulation resulting in formation of a cellular spore
C0971_RS17235	COG4836	Membrane
C0971_RS17240	COG1007	ATP synthesis coupled electron transport
C0971_RS17245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_RS17250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0971_RS17255	COG0713	ATP synthesis coupled electron transport
C0971_RS17260	COG0839	Belongs to the complex I subunit 6 family
C0971_RS17270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0971_RS17280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_RS17285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_RS17290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_RS17295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0971_RS17300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0971_RS17305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0971_RS17310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0971_RS17315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0971_RS17320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0971_RS17325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0971_RS17330	COG0356	it plays a direct role in the translocation of protons across the membrane
C0971_RS17345	COG1404	Belongs to the peptidase S8 family
C0971_RS17355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0971_RS17370	COG0698	ribose 5-phosphate isomerase
C0971_RS17375	COG0840	transmembrane signaling receptor activity
C0971_RS17385	COG1971	Probably functions as a manganese efflux pump
C0971_RS17390	COG0009	L-threonylcarbamoyladenylate synthase
C0971_RS17400	COG2890	protein-(glutamine-N5) methyltransferase activity
C0971_RS17405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0971_RS17410	COG1435	thymidine kinase activity
C0971_RS17420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0971_RS17425	COG1494	fructose-1,6-bisphosphatase
C0971_RS17430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0971_RS17435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0971_RS17440	COG0191	fructose-bisphosphate aldolase activity
C0971_RS17445	COG2204	response regulator
C0971_RS17450	COG4821	SIS domain
C0971_RS17455	COG0504	CTP synthase activity
C0971_RS17460	COG3343	RNA polymerase activity
C0971_RS17470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_RS17470	COG1703	isobutyryl-CoA mutase activity
C0971_RS17470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_RS17480	COG1960	acyl-CoA dehydrogenase activity
C0971_RS17485	COG1960	acyl-CoA dehydrogenase activity
C0971_RS17490	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0971_RS17495	COG0183	Belongs to the thiolase family
C0971_RS17500	COG2181	nitrate reductase activity
C0971_RS17500	COG0247	lactate metabolic process
C0971_RS17505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0971_RS17515	COG0018	arginyl-trna synthetase
C0971_RS17520	COG4506	Protein conserved in bacteria
C0971_RS17525	COG0010	Belongs to the arginase family
C0971_RS17530	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0971_RS17535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_RS17545	COG1994	Peptidase M50
C0971_RS17555	COG3465	dGTPase activity
C0971_RS17560	COG1078	dGTPase activity
C0971_RS17565	COG4844	belongs to the
C0971_RS17580	COG0280	phosphate acetyltransferase
C0971_RS17585	COG3253	May function as heme-dependent peroxidase
C0971_RS17595	COG2363	Small membrane protein
C0971_RS17605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0971_RS17610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C0971_RS17615	COG0314	molybdopterin synthase activity
C0971_RS17620	COG0746	molybdenum cofactor guanylyltransferase activity
C0971_RS17625	COG0351	phosphomethylpyrimidine kinase
C0971_RS17630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_RS17635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_RS17645	COG1131	(ABC) transporter
C0971_RS17650	COG0842	Transport permease protein
C0971_RS17650	COG1511	domain protein
C0971_RS17680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0971_RS17685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_RS17690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_RS17690	COG0723	plastoquinol--plastocyanin reductase activity
C0971_RS17695	COG0492	ferredoxin-NADP+ reductase activity
C0971_RS17710	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0971_RS17720	COG3118	belongs to the thioredoxin family
C0971_RS17745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0971_RS17765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_RS17770	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C0971_RS17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_RS17780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_RS17785	COG1120	ATPase activity
C0971_RS17805	COG1131	(ABC) transporter
C0971_RS17810	COG1309	transcriptional regulator
C0971_RS17815	COG3842	ATPase activity
C0971_RS17820	COG3833	ABC-type maltose transport systems, permease component
C0971_RS17840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0971_RS17860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0971_RS17870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_RS17875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C0971_RS17880	COG4853	Protein conserved in bacteria
C0971_RS17885	COG4863	YycH protein
C0971_RS17890	COG5002	protein histidine kinase activity
C0971_RS17895	COG0745	RESPONSE REGULATOR receiver
C0971_RS17920	COG2814	Major facilitator Superfamily
C0971_RS17925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0971_RS17930	COG0305	Participates in initiation and elongation during chromosome replication
C0971_RS17935	COG0359	binds to the 23S rRNA
C0971_RS17940	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C0971_RS17945	COG4241	membrane
C0971_RS17955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0971_RS17960	COG0629	single-stranded DNA binding
C0971_RS17965	COG0360	Binds together with S18 to 16S ribosomal RNA
C0971_RS17970	COG0438	transferase activity, transferring glycosyl groups
C0971_RS17980	COG0012	GTP binding
C0971_RS17985	COG4481	Protein conserved in bacteria
C0971_RS17990	COG0668	transmembrane transport
C0971_RS18005	COG1475	DNA binding
C0971_RS18010	COG1192	Involved in chromosome partitioning
C0971_RS18015	COG1475	DNA binding
C0971_RS18020	COG0357	Ribosomal RNA small subunit methyltransferase G
C0971_RS18025	COG0445	tRNA wobble uridine modification
C0971_RS18030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0971_RS18035	COG1847	R3H domain protein
C0971_RS18045	COG0594	ribonuclease P activity
C0971_RS18050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C0971_RS18060	COG1923	regulation of RNA biosynthetic process
C0971_RS18095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0971_RS18130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0971_RS18135	COG0191	fructose-bisphosphate aldolase activity
C0971_RS18140	COG1494	fructose-1,6-bisphosphatase