locus-tag	class	description
MLA2C4_RS00010	COG0592	DNA-directed DNA polymerase activity
MLA2C4_RS00015	COG2501	S4 domain
MLA2C4_RS00025	COG0187	DNA topoisomerase II activity
MLA2C4_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MLA2C4_RS00065	COG0516	GMP reductase activity
MLA2C4_RS00065	COG0517	IMP dehydrogenase activity
MLA2C4_RS00070	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS00100	COG1428	Deoxynucleoside kinase
MLA2C4_RS00105	COG1428	Deoxynucleoside kinase
MLA2C4_RS00110	COG1335	isochorismatase
MLA2C4_RS00115	COG0590	tRNA wobble adenosine to inosine editing
MLA2C4_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MLA2C4_RS00180	COG1982	Orn Lys Arg decarboxylase major
MLA2C4_RS00190	COG0470	DNA polymerase III
MLA2C4_RS00195	COG1774	PSP1 C-terminal conserved region
MLA2C4_RS00200	COG4467	Involved in initiation control of chromosome replication
MLA2C4_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MLA2C4_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MLA2C4_RS00220	COG2002	toxin-antitoxin pair type II binding
MLA2C4_RS00230	COG0084	hydrolase, TatD family'
MLA2C4_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MLA2C4_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MLA2C4_RS00250	COG4466	Protein conserved in bacteria
MLA2C4_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MLA2C4_RS00270	COG0251	oxidation-reduction process
MLA2C4_RS00275	COG2088	sporulation resulting in formation of a cellular spore
MLA2C4_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MLA2C4_RS00305	COG2002	toxin-antitoxin pair type II binding
MLA2C4_RS00310	COG2244	polysaccharide biosynthetic process
MLA2C4_RS00315	COG3956	TIGRFAM MazG family protein
MLA2C4_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MLA2C4_RS00340	COG1098	S1 RNA binding domain
MLA2C4_RS00355	COG2208	phosphoserine phosphatase activity
MLA2C4_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MLA2C4_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MLA2C4_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLA2C4_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MLA2C4_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
MLA2C4_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLA2C4_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MLA2C4_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MLA2C4_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MLA2C4_RS00420	COG1396	sequence-specific DNA binding
MLA2C4_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MLA2C4_RS00515	COG3880	PFAM UvrB UvrC protein
MLA2C4_RS00525	COG0542	response to heat
MLA2C4_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MLA2C4_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
MLA2C4_RS00560	COG1045	serine acetyltransferase
MLA2C4_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLA2C4_RS00580	COG3688	RNA-binding protein containing a PIN domain
MLA2C4_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MLA2C4_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
MLA2C4_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MLA2C4_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MLA2C4_RS00620	COG0222	ribosome binding
MLA2C4_RS00625	COG2813	Specifically methylates the guanine in position
MLA2C4_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MLA2C4_RS00640	COG1358	cellular component organization or biogenesis
MLA2C4_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MLA2C4_RS00670	COG0051	transcription antitermination factor activity, RNA binding
MLA2C4_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MLA2C4_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
MLA2C4_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MLA2C4_RS00765	COG1841	ribosomal large subunit assembly
MLA2C4_RS00775	COG0201	protein transport
MLA2C4_RS00785	COG0024	Methionine aminopeptidase
MLA2C4_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MLA2C4_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MLA2C4_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS00860	COG0489	protein tyrosine kinase activity
MLA2C4_RS00870	COG2194	sulfuric ester hydrolase activity
MLA2C4_RS00875	COG0726	polysaccharide deacetylase
MLA2C4_RS00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MLA2C4_RS00960	COG4856	YbbR-like protein
MLA2C4_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS01015	COG2011	ABC-type metal ion transport system permease component
MLA2C4_RS01025	COG1464	Belongs to the NlpA lipoprotein family
MLA2C4_RS01030	COG0604	alcohol dehydrogenase
MLA2C4_RS01040	COG0277	FAD linked oxidase domain protein
MLA2C4_RS01045	COG2271	Major facilitator Superfamily
MLA2C4_RS01055	COG2814	Major facilitator Superfamily
MLA2C4_RS01080	COG0601	transmembrane transport
MLA2C4_RS01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLA2C4_RS01090	COG0444	Belongs to the ABC transporter superfamily
MLA2C4_RS01095	COG4608	Belongs to the ABC transporter superfamily
MLA2C4_RS01100	COG4166	transmembrane transport
MLA2C4_RS01110	COG2207	Transcriptional regulator
MLA2C4_RS01125	COG4166	transmembrane transport
MLA2C4_RS01130	COG4166	transmembrane transport
MLA2C4_RS01135	COG0656	L-ascorbic acid biosynthetic process
MLA2C4_RS01150	COG4149	molybdate abc transporter
MLA2C4_RS01155	COG0725	ABC transporter, periplasmic molybdate-binding protein
MLA2C4_RS01160	COG1910	domain protein
MLA2C4_RS01175	COG0697	spore germination
MLA2C4_RS01190	COG0204	Acyl-transferase
MLA2C4_RS01205	COG1609	Transcriptional regulator
MLA2C4_RS01215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS01225	COG0084	hydrolase, TatD family'
MLA2C4_RS01235	COG5298	Protein conserved in bacteria
MLA2C4_RS01255	COG0488	(ABC) transporter
MLA2C4_RS01260	COG4585	Histidine kinase
MLA2C4_RS01265	COG2197	response regulator
MLA2C4_RS01270	COG1131	(ABC) transporter
MLA2C4_RS01275	COG1511	domain protein
MLA2C4_RS01275	COG0842	Transport permease protein
MLA2C4_RS01280	COG0842	Transport permease protein
MLA2C4_RS01290	COG0747	negative chemotaxis
MLA2C4_RS01295	COG0747	negative chemotaxis
MLA2C4_RS01300	COG0601	transmembrane transport
MLA2C4_RS01305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLA2C4_RS01310	COG0444	Belongs to the ABC transporter superfamily
MLA2C4_RS01315	COG4608	Belongs to the ABC transporter superfamily
MLA2C4_RS01320	COG0561	phosphatase activity
MLA2C4_RS01355	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MLA2C4_RS01360	COG0179	Fumarylacetoacetate (FAA) hydrolase
MLA2C4_RS01370	COG0531	amino acid
MLA2C4_RS01385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MLA2C4_RS01395	COG4294	response to UV
MLA2C4_RS01400	COG0705	Rhomboid family
MLA2C4_RS01410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MLA2C4_RS01415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MLA2C4_RS01420	COG0864	Transcriptional regulator
MLA2C4_RS01425	COG2337	Toxic component of a toxin-antitoxin (TA) module
MLA2C4_RS01430	COG2183	response to ionizing radiation
MLA2C4_RS01530	COG0802	atpase or kinase
MLA2C4_RS01535	COG1214	PFAM Peptidase M22, glycoprotease
MLA2C4_RS01540	COG0456	acetyltransferase
MLA2C4_RS01550	COG0488	(ABC) transporter
MLA2C4_RS01555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MLA2C4_RS01565	COG1266	CAAX protease self-immunity
MLA2C4_RS01575	COG0459	protein refolding
MLA2C4_RS01595	COG2252	PERMEase
MLA2C4_RS01605	COG5002	protein histidine kinase activity
MLA2C4_RS01630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MLA2C4_RS01675	COG1215	transferase activity, transferring glycosyl groups
MLA2C4_RS01695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS01700	COG0506	proline dehydrogenase activity
MLA2C4_RS01720	COG0697	spore germination
MLA2C4_RS01745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MLA2C4_RS01750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MLA2C4_RS01755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MLA2C4_RS01765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MLA2C4_RS01780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MLA2C4_RS01790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MLA2C4_RS01800	COG0151	Belongs to the GarS family
MLA2C4_RS01830	COG0210	DNA helicase
MLA2C4_RS01840	COG4851	CamS sex pheromone cAM373 precursor
MLA2C4_RS01855	COG1335	isochorismatase
MLA2C4_RS01870	COG2011	ABC-type metal ion transport system permease component
MLA2C4_RS01875	COG1464	Belongs to the NlpA lipoprotein family
MLA2C4_RS01890	COG0003	Pfam Anion-transporting ATPase
MLA2C4_RS01895	COG1846	Transcriptional regulator
MLA2C4_RS01900	COG4682	membrane
MLA2C4_RS01920	COG1597	lipid kinase activity
MLA2C4_RS01925	COG0546	phosphoglycolate phosphatase activity
MLA2C4_RS01930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MLA2C4_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS01945	COG2076	Multidrug Resistance protein
MLA2C4_RS01950	COG2309	aminopeptidase activity
MLA2C4_RS01965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MLA2C4_RS01980	COG5002	protein histidine kinase activity
MLA2C4_RS01985	COG4807	Protein conserved in bacteria
MLA2C4_RS02010	COG1757	Na H antiporter
MLA2C4_RS02015	COG1473	amidohydrolase
MLA2C4_RS02030	COG0450	alkyl hydroperoxide reductase
MLA2C4_RS02040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MLA2C4_RS02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS02065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS02075	COG0492	ferredoxin-NADP+ reductase activity
MLA2C4_RS02090	COG0166	Belongs to the GPI family
MLA2C4_RS02135	COG3541	Predicted nucleotidyltransferase
MLA2C4_RS02140	COG2814	Major facilitator Superfamily
MLA2C4_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
MLA2C4_RS02145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLA2C4_RS02155	COG0765	amino acid transport
MLA2C4_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS02180	COG0840	transmembrane signaling receptor activity
MLA2C4_RS02190	COG0366	Alpha amylase catalytic
MLA2C4_RS02195	COG1263	PTS System
MLA2C4_RS02195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS02195	COG2190	(PTS) system
MLA2C4_RS02240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLA2C4_RS02255	COG4152	abc transporter atp-binding protein
MLA2C4_RS02260	COG1668	transmembrane transport
MLA2C4_RS02290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MLA2C4_RS02305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLA2C4_RS02315	COG1116	anion transmembrane transporter activity
MLA2C4_RS02325	COG0488	(ABC) transporter
MLA2C4_RS02375	COG2270	Major facilitator Superfamily
MLA2C4_RS02405	COG2310	stress, protein
MLA2C4_RS02410	COG2310	stress, protein
MLA2C4_RS02415	COG2310	stress, protein
MLA2C4_RS02420	COG0861	Integral membrane protein TerC family
MLA2C4_RS02430	COG3853	Toxic anion resistance protein (TelA)
MLA2C4_RS02445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MLA2C4_RS02455	COG1295	ribonuclease BN
MLA2C4_RS02460	COG2217	Heavy metal translocating P-type atpase
MLA2C4_RS02465	COG0697	spore germination
MLA2C4_RS02475	COG0681	Belongs to the peptidase S26 family
MLA2C4_RS02485	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS02500	COG3871	stress protein (general stress protein 26)
MLA2C4_RS02510	COG0387	Pfam Sodium calcium exchanger
MLA2C4_RS02520	COG0535	radical SAM domain protein
MLA2C4_RS02540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MLA2C4_RS02560	COG3829	transcription factor binding
MLA2C4_RS02570	COG0833	amino acid
MLA2C4_RS02575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLA2C4_RS02600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS02600	COG1263	PTS System
MLA2C4_RS02605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MLA2C4_RS02625	COG0463	Glycosyl transferase, family 2
MLA2C4_RS02635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLA2C4_RS02635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MLA2C4_RS02640	COG0463	Glycosyl transferase, family 2
MLA2C4_RS02650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MLA2C4_RS02670	COG1228	amidohydrolase
MLA2C4_RS02675	COG1090	epimerase
MLA2C4_RS02705	COG1988	membrane-bound metal-dependent
MLA2C4_RS02710	COG1194	a g-specific adenine glycosylase
MLA2C4_RS02740	COG1132	(ABC) transporter
MLA2C4_RS02745	COG4129	membrane
MLA2C4_RS02750	COG0067	glutamate synthase
MLA2C4_RS02750	COG0070	glutamate synthase
MLA2C4_RS02750	COG0069	glutamate synthase activity
MLA2C4_RS02760	COG4555	ABC transporter
MLA2C4_RS02780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MLA2C4_RS02785	COG0735	belongs to the Fur family
MLA2C4_RS02900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MLA2C4_RS02930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MLA2C4_RS02940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MLA2C4_RS02950	COG2766	serine protein kinase
MLA2C4_RS02970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MLA2C4_RS02980	COG1585	Membrane protein implicated in regulation of membrane protease activity
MLA2C4_RS02985	COG2268	Band 7 protein
MLA2C4_RS02995	COG3290	protein histidine kinase activity
MLA2C4_RS03000	COG4565	transcriptional regulatory protein
MLA2C4_RS03005	COG2851	Citrate transporter
MLA2C4_RS03035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MLA2C4_RS03040	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS03045	COG5002	protein histidine kinase activity
MLA2C4_RS03055	COG4990	cell redox homeostasis
MLA2C4_RS03065	COG3290	protein histidine kinase activity
MLA2C4_RS03070	COG4565	transcriptional regulatory protein
MLA2C4_RS03075	COG3493	citrate carrier protein
MLA2C4_RS03080	COG0281	malic enzyme
MLA2C4_RS03090	COG0697	spore germination
MLA2C4_RS03095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS03105	COG5002	protein histidine kinase activity
MLA2C4_RS03110	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS03115	COG0454	-acetyltransferase
MLA2C4_RS03115	COG0456	acetyltransferase
MLA2C4_RS03120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MLA2C4_RS03125	COG3383	formate dehydrogenase (NAD+) activity
MLA2C4_RS03130	COG2427	Protein of unknown function (DUF1641)
MLA2C4_RS03145	COG0531	amino acid
MLA2C4_RS03150	COG0640	Transcriptional regulator
MLA2C4_RS03155	COG2217	Heavy metal translocating P-type atpase
MLA2C4_RS03160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MLA2C4_RS03170	COG3227	Zinc metalloprotease (Elastase)
MLA2C4_RS03190	COG2720	vancomycin resistance protein
MLA2C4_RS03195	COG1316	TRANSCRIPTIONal
MLA2C4_RS03200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS03205	COG0346	lactoylglutathione lyase activity
MLA2C4_RS03210	COG1253	flavin adenine dinucleotide binding
MLA2C4_RS03215	COG1027	Aspartate ammonia-lyase
MLA2C4_RS03220	COG1620	l-lactate permease
MLA2C4_RS03235	COG3104	oligopeptide transport
MLA2C4_RS03240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS03245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS03260	COG2226	methyltransferase
MLA2C4_RS03265	COG0156	8-amino-7-oxononanoate synthase activity
MLA2C4_RS03270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLA2C4_RS03280	COG4548	von Willebrand factor, type A
MLA2C4_RS03285	COG0714	Associated with various cellular activities
MLA2C4_RS03290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLA2C4_RS03310	COG0531	amino acid
MLA2C4_RS03315	COG2188	Transcriptional regulator
MLA2C4_RS03320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS03320	COG1263	PTS System
MLA2C4_RS03325	COG0366	Alpha amylase catalytic
MLA2C4_RS03340	COG0697	spore germination
MLA2C4_RS03345	COG4585	Histidine kinase
MLA2C4_RS03350	COG2197	response regulator
MLA2C4_RS03355	COG1404	Belongs to the peptidase S8 family
MLA2C4_RS03370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MLA2C4_RS03375	COG1115	amino acid carrier protein
MLA2C4_RS03380	COG1126	abc transporter atp-binding protein
MLA2C4_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS03390	COG0765	amino acid transport
MLA2C4_RS03395	COG0765	amino acid transport
MLA2C4_RS03400	COG0833	amino acid
MLA2C4_RS03425	COG2378	regulation of single-species biofilm formation
MLA2C4_RS03430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MLA2C4_RS03435	COG5002	protein histidine kinase activity
MLA2C4_RS03450	COG0659	secondary active sulfate transmembrane transporter activity
MLA2C4_RS03475	COG0601	transmembrane transport
MLA2C4_RS03480	COG4608	Belongs to the ABC transporter superfamily
MLA2C4_RS03490	COG2271	Major facilitator Superfamily
MLA2C4_RS03495	COG1846	Transcriptional regulator
MLA2C4_RS03500	COG0477	Major facilitator Superfamily
MLA2C4_RS03505	COG1609	Transcriptional regulator
MLA2C4_RS03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MLA2C4_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLA2C4_RS03530	COG1879	ABC-type sugar transport system periplasmic component
MLA2C4_RS03555	COG1063	alcohol dehydrogenase
MLA2C4_RS03570	COG3568	Endonuclease Exonuclease Phosphatase
MLA2C4_RS03600	COG0840	transmembrane signaling receptor activity
MLA2C4_RS03605	COG3584	3D domain protein
MLA2C4_RS03605	COG3583	domain protein
MLA2C4_RS03610	COG1476	TRANSCRIPTIONal
MLA2C4_RS03630	COG3104	oligopeptide transport
MLA2C4_RS03635	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS03650	COG1113	amino acid transport
MLA2C4_RS03655	COG2252	PERMEase
MLA2C4_RS03670	COG2153	protein acetylation
MLA2C4_RS03680	COG0569	domain protein
MLA2C4_RS03680	COG0475	glutathione-regulated potassium exporter activity
MLA2C4_RS03690	COG1845	cytochrome c oxidase, subunit III
MLA2C4_RS03695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MLA2C4_RS03700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MLA2C4_RS03705	COG0833	amino acid
MLA2C4_RS03710	COG4990	cell redox homeostasis
MLA2C4_RS03725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLA2C4_RS03730	COG0697	spore germination
MLA2C4_RS03735	COG0531	amino acid
MLA2C4_RS03745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MLA2C4_RS03750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MLA2C4_RS03755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MLA2C4_RS03755	COG1918	ferrous iron import across plasma membrane
MLA2C4_RS03760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MLA2C4_RS03765	COG0573	inorganic phosphate transmembrane transporter activity
MLA2C4_RS03770	COG0581	inorganic phosphate transmembrane transporter activity
MLA2C4_RS03780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLA2C4_RS03900	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MLA2C4_RS03920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MLA2C4_RS03925	COG1116	anion transmembrane transporter activity
MLA2C4_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLA2C4_RS03935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLA2C4_RS03940	COG0352	thiamine-phosphate diphosphorylase activity
MLA2C4_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLA2C4_RS03950	COG2104	thiamine diphosphate biosynthetic process
MLA2C4_RS03960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLA2C4_RS03965	COG0351	phosphomethylpyrimidine kinase
MLA2C4_RS04005	COG2205	protein histidine kinase activity
MLA2C4_RS04010	COG2814	Major facilitator Superfamily
MLA2C4_RS04015	COG1846	Transcriptional regulator
MLA2C4_RS04040	COG1136	(ABC) transporter
MLA2C4_RS04050	COG2252	PERMEase
MLA2C4_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS04115	COG0778	Nitroreductase
MLA2C4_RS04130	COG2201	protein-glutamate methylesterase activity
MLA2C4_RS04160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MLA2C4_RS04160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MLA2C4_RS04165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MLA2C4_RS04240	COG3591	Belongs to the peptidase S1B family
MLA2C4_RS04265	COG0446	pyridine nucleotide-disulphide oxidoreductase
MLA2C4_RS04270	COG1937	Protein conserved in bacteria
MLA2C4_RS04280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLA2C4_RS04280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS04285	COG0425	Belongs to the sulfur carrier protein TusA family
MLA2C4_RS04290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLA2C4_RS04290	COG0425	Belongs to the sulfur carrier protein TusA family
MLA2C4_RS04295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLA2C4_RS04300	COG2210	Belongs to the sulfur carrier protein TusA family
MLA2C4_RS04305	COG0730	response to heat
MLA2C4_RS04315	COG1316	TRANSCRIPTIONal
MLA2C4_RS04320	COG0604	alcohol dehydrogenase
MLA2C4_RS04325	COG1283	sodium-dependent phosphate transmembrane transporter activity
MLA2C4_RS04330	COG2814	Major facilitator Superfamily
MLA2C4_RS04345	COG3711	transcriptional antiterminator
MLA2C4_RS04345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLA2C4_RS04350	COG1447	Phosphotransferase system cellobiose-specific component IIA
MLA2C4_RS04355	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MLA2C4_RS04375	COG1388	LysM domain
MLA2C4_RS04375	COG3584	3D domain protein
MLA2C4_RS04380	COG0577	efflux transmembrane transporter activity
MLA2C4_RS04385	COG1136	(ABC) transporter
MLA2C4_RS04395	COG5522	Integral membrane protein (intg_mem_TP0381)
MLA2C4_RS04410	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS04415	COG3546	catalase activity
MLA2C4_RS04450	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS04480	COG0531	amino acid
MLA2C4_RS04490	COG0475	glutathione-regulated potassium exporter activity
MLA2C4_RS04500	COG1737	Transcriptional regulator
MLA2C4_RS04510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS04510	COG1263	PTS System
MLA2C4_RS04520	COG2259	Doxx family
MLA2C4_RS04535	COG0697	spore germination
MLA2C4_RS04540	COG1522	sequence-specific DNA binding
MLA2C4_RS04565	COG2076	Multidrug Resistance protein
MLA2C4_RS04570	COG1309	transcriptional regulator
MLA2C4_RS04575	COG2814	Major facilitator Superfamily
MLA2C4_RS04580	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS04590	COG2249	NAD(P)H dehydrogenase (quinone) activity
MLA2C4_RS04600	COG4533	DNA binding
MLA2C4_RS04605	COG2211	Major facilitator Superfamily
MLA2C4_RS04615	COG0693	protein deglycase activity
MLA2C4_RS04625	COG0531	amino acid
MLA2C4_RS04630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MLA2C4_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS04645	COG1132	(ABC) transporter
MLA2C4_RS04650	COG1132	(ABC) transporter
MLA2C4_RS04660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS04665	COG0765	amino acid transport
MLA2C4_RS04670	COG1126	abc transporter atp-binding protein
MLA2C4_RS04685	COG0189	ligase activity
MLA2C4_RS04715	COG0028	Belongs to the TPP enzyme family
MLA2C4_RS04720	COG3527	Alpha-acetolactate decarboxylase
MLA2C4_RS04735	COG0561	phosphatase activity
MLA2C4_RS04745	COG5632	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS04745	COG3409	Peptidoglycan-binding domain 1 protein
MLA2C4_RS04750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLA2C4_RS04755	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS04765	COG0659	secondary active sulfate transmembrane transporter activity
MLA2C4_RS04780	COG0653	protein targeting
MLA2C4_RS04785	COG2244	polysaccharide biosynthetic process
MLA2C4_RS04795	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS04815	COG1696	Membrane protein involved in D-alanine export
MLA2C4_RS04830	COG1024	Enoyl-CoA hydratase
MLA2C4_RS04850	COG1363	Peptidase, m42
MLA2C4_RS04910	COG0477	Major facilitator Superfamily
MLA2C4_RS04915	COG3290	protein histidine kinase activity
MLA2C4_RS04920	COG4565	transcriptional regulatory protein
MLA2C4_RS04925	COG3181	Tripartite tricarboxylate transporter family receptor
MLA2C4_RS04985	COG0305	Participates in initiation and elongation during chromosome replication
MLA2C4_RS05005	COG0305	Participates in initiation and elongation during chromosome replication
MLA2C4_RS05030	COG0477	Major facilitator Superfamily
MLA2C4_RS05080	COG2226	methyltransferase
MLA2C4_RS05100	COG3711	transcriptional antiterminator
MLA2C4_RS05105	COG2190	(PTS) system
MLA2C4_RS05105	COG1263	PTS System
MLA2C4_RS05105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS05110	COG2723	6-phospho-beta-galactosidase activity
MLA2C4_RS05120	COG1183	phosphatidylcholine synthase activity
MLA2C4_RS05135	COG2814	Major facilitator Superfamily
MLA2C4_RS05140	COG0640	Transcriptional regulator
MLA2C4_RS05170	COG2376	Dihydroxyacetone kinase
MLA2C4_RS05185	COG2376	Dihydroxyacetone kinase
MLA2C4_RS05195	COG1959	2 iron, 2 sulfur cluster binding
MLA2C4_RS05245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLA2C4_RS05270	COG0596	Alpha beta hydrolase
MLA2C4_RS05315	COG2172	sigma factor antagonist activity
MLA2C4_RS05320	COG1191	sigma factor activity
MLA2C4_RS05330	COG2208	phosphoserine phosphatase activity
MLA2C4_RS05335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MLA2C4_RS05340	COG0784	Response regulator, receiver
MLA2C4_RS05340	COG2205	protein histidine kinase activity
MLA2C4_RS05340	COG5002	protein histidine kinase activity
MLA2C4_RS05380	COG4585	Histidine kinase
MLA2C4_RS05385	COG2197	response regulator
MLA2C4_RS05415	COG0420	3'-5' exonuclease activity
MLA2C4_RS05420	COG4717	serine-type aminopeptidase activity
MLA2C4_RS05450	COG0346	lactoylglutathione lyase activity
MLA2C4_RS05455	COG0346	lactoylglutathione lyase activity
MLA2C4_RS05460	COG0457	Tetratricopeptide repeat
MLA2C4_RS05470	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS05500	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MLA2C4_RS05505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MLA2C4_RS05515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MLA2C4_RS05525	COG1595	DNA-templated transcription, initiation
MLA2C4_RS05535	COG0772	Belongs to the SEDS family
MLA2C4_RS05545	COG3973	AAA domain
MLA2C4_RS05555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLA2C4_RS05580	COG0537	adenosine 5'-monophosphoramidase activity
MLA2C4_RS05585	COG1131	(ABC) transporter
MLA2C4_RS05590	COG4473	ABC transporter
MLA2C4_RS05650	COG1309	transcriptional regulator
MLA2C4_RS05655	COG3402	PFAM membrane-flanked domain
MLA2C4_RS05660	COG3428	Bacterial PH domain
MLA2C4_RS05685	COG3402	PFAM membrane-flanked domain
MLA2C4_RS05690	COG3428	Bacterial PH domain
MLA2C4_RS05695	COG2329	Antibiotic biosynthesis monooxygenase
MLA2C4_RS05700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLA2C4_RS05715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MLA2C4_RS05750	COG1309	transcriptional regulator
MLA2C4_RS05755	COG1511	domain protein
MLA2C4_RS05770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS05780	COG2378	regulation of single-species biofilm formation
MLA2C4_RS05785	COG1609	Transcriptional regulator
MLA2C4_RS05795	COG1234	tRNA 3'-trailer cleavage
MLA2C4_RS05800	COG0095	Lipoate-protein ligase
MLA2C4_RS05810	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS05830	COG1073	alpha beta
MLA2C4_RS05835	COG1408	metallophosphoesterase
MLA2C4_RS05840	COG1078	dGTPase activity
MLA2C4_RS05850	COG0477	Major facilitator Superfamily
MLA2C4_RS05860	COG1595	DNA-templated transcription, initiation
MLA2C4_RS05870	COG2207	Transcriptional regulator
MLA2C4_RS05870	COG3708	Transcriptional regulator
MLA2C4_RS05875	COG2205	protein histidine kinase activity
MLA2C4_RS05880	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS05905	COG0501	Belongs to the peptidase M48B family
MLA2C4_RS05910	COG0840	transmembrane signaling receptor activity
MLA2C4_RS05915	COG0697	spore germination
MLA2C4_RS05935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MLA2C4_RS05940	COG2224	Isocitrate lyase
MLA2C4_RS05950	COG1278	Cold shock
MLA2C4_RS05980	COG0398	Pfam SNARE associated Golgi protein
MLA2C4_RS06040	COG0179	Fumarylacetoacetate (FAA) hydrolase
MLA2C4_RS06065	COG0367	asparagine synthase
MLA2C4_RS06075	COG0753	catalase activity
MLA2C4_RS06085	COG0004	ammonium transporteR
MLA2C4_RS06115	COG2996	Protein conserved in bacteria
MLA2C4_RS06120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLA2C4_RS06130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS06145	COG0561	phosphatase activity
MLA2C4_RS06165	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS06180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLA2C4_RS06185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MLA2C4_RS06190	COG5504	Zn-dependent protease
MLA2C4_RS06200	COG0180	Tryptophanyl-tRNA synthetase
MLA2C4_RS06215	COG4166	transmembrane transport
MLA2C4_RS06220	COG0601	transmembrane transport
MLA2C4_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MLA2C4_RS06230	COG0444	Belongs to the ABC transporter superfamily
MLA2C4_RS06235	COG4608	Belongs to the ABC transporter superfamily
MLA2C4_RS06240	COG0534	Mate efflux family protein
MLA2C4_RS06245	COG4166	transmembrane transport
MLA2C4_RS06260	COG0861	Integral membrane protein TerC family
MLA2C4_RS06270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLA2C4_RS06280	COG1164	Oligoendopeptidase f
MLA2C4_RS06290	COG2346	COG2346, Truncated hemoglobins
MLA2C4_RS06295	COG4116	CYTH
MLA2C4_RS06305	COG2357	RelA SpoT domain protein
MLA2C4_RS06315	COG0564	pseudouridine synthase activity
MLA2C4_RS06330	COG0772	Belongs to the SEDS family
MLA2C4_RS06335	COG1216	Glycosyl transferase, family 2
MLA2C4_RS06355	COG0463	Glycosyl transferase, family 2
MLA2C4_RS06355	COG0457	Tetratricopeptide repeat
MLA2C4_RS06375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MLA2C4_RS06390	COG1091	dTDP-4-dehydrorhamnose reductase activity
MLA2C4_RS06435	COG2153	protein acetylation
MLA2C4_RS06445	COG2382	esterase
MLA2C4_RS06475	COG5492	domain, Protein
MLA2C4_RS06480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLA2C4_RS06495	COG0512	Glutamine amidotransferase of anthranilate synthase
MLA2C4_RS06495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MLA2C4_RS06515	COG0133	tryptophan synthase activity
MLA2C4_RS06530	COG1620	l-lactate permease
MLA2C4_RS06535	COG5634	Uncharacterized conserved protein (DUF2278)
MLA2C4_RS06570	COG2226	methyltransferase
MLA2C4_RS06590	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLA2C4_RS06600	COG1476	TRANSCRIPTIONal
MLA2C4_RS06710	COG2003	Belongs to the UPF0758 family
MLA2C4_RS06740	COG0582	viral genome integration into host DNA
MLA2C4_RS06745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLA2C4_RS06795	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS06800	COG0681	Belongs to the peptidase S26 family
MLA2C4_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS06845	COG1176	ABC-type spermidine putrescine transport system, permease component I
MLA2C4_RS06850	COG1177	transmembrane transport
MLA2C4_RS06855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MLA2C4_RS06860	COG0671	phosphoesterase, PA-phosphatase related
MLA2C4_RS06865	COG2409	Drug exporters of the RND superfamily
MLA2C4_RS06875	COG0564	pseudouridine synthase activity
MLA2C4_RS06885	COG2340	Cysteine-rich secretory protein family
MLA2C4_RS06890	COG0247	lactate metabolic process
MLA2C4_RS06895	COG0277	FAD linked oxidase domain protein
MLA2C4_RS06900	COG3835	regulator
MLA2C4_RS06910	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS06915	COG5002	protein histidine kinase activity
MLA2C4_RS06920	COG2186	Transcriptional regulator
MLA2C4_RS06940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MLA2C4_RS06950	COG2116	formate transmembrane transporter activity
MLA2C4_RS06955	COG0861	Integral membrane protein TerC family
MLA2C4_RS06970	COG2030	dehydratase
MLA2C4_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS06995	COG3243	poly(R)-hydroxyalkanoic acid synthase
MLA2C4_RS07005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MLA2C4_RS07020	COG1840	ABC-type Fe3 transport system, periplasmic component
MLA2C4_RS07025	COG3842	ATPase activity
MLA2C4_RS07050	COG1349	DNA-binding transcription factor activity
MLA2C4_RS07060	COG0235	Class ii aldolase
MLA2C4_RS07070	COG2861	carbohydrate metabolic process
MLA2C4_RS07080	COG3852	Histidine kinase
MLA2C4_RS07085	COG1846	Transcriptional regulator
MLA2C4_RS07095	COG2318	DinB family
MLA2C4_RS07105	COG5002	protein histidine kinase activity
MLA2C4_RS07115	COG0720	synthase
MLA2C4_RS07130	COG4873	Protein conserved in bacteria
MLA2C4_RS07165	COG1780	Probably involved in ribonucleotide reductase function
MLA2C4_RS07180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MLA2C4_RS07185	COG1725	Transcriptional regulator
MLA2C4_RS07190	COG1131	(ABC) transporter
MLA2C4_RS07200	COG1131	(ABC) transporter
MLA2C4_RS07205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MLA2C4_RS07210	COG1266	CAAX protease self-immunity
MLA2C4_RS07220	COG1522	sequence-specific DNA binding
MLA2C4_RS07230	COG1335	isochorismatase
MLA2C4_RS07240	COG1619	proteins homologs of microcin C7 resistance protein MccF
MLA2C4_RS07255	COG2070	2-Nitropropane dioxygenase
MLA2C4_RS07260	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MLA2C4_RS07270	COG1696	Membrane protein involved in D-alanine export
MLA2C4_RS07290	COG0716	FMN binding
MLA2C4_RS07335	COG1846	Transcriptional regulator
MLA2C4_RS07345	COG1301	dicarboxylic acid transport
MLA2C4_RS07350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MLA2C4_RS07355	COG4709	membrane
MLA2C4_RS07360	COG3874	Sporulation protein YtfJ
MLA2C4_RS07385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLA2C4_RS07390	COG0028	Belongs to the TPP enzyme family
MLA2C4_RS07395	COG0440	acetolactate synthase activity
MLA2C4_RS07470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MLA2C4_RS07485	COG1183	phosphatidylcholine synthase activity
MLA2C4_RS07490	COG1368	sulfuric ester hydrolase activity
MLA2C4_RS07500	COG0019	diaminopimelate decarboxylase activity
MLA2C4_RS07520	COG0529	Catalyzes the synthesis of activated sulfate
MLA2C4_RS07525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MLA2C4_RS07545	COG1648	precorrin-2 dehydrogenase activity
MLA2C4_RS07555	COG0733	neurotransmitter:sodium symporter activity
MLA2C4_RS07575	COG1757	Na H antiporter
MLA2C4_RS07590	COG4758	membrane
MLA2C4_RS07595	COG4585	Histidine kinase
MLA2C4_RS07600	COG2197	response regulator
MLA2C4_RS07610	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS07620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MLA2C4_RS07660	COG0730	response to heat
MLA2C4_RS07665	COG0306	phosphate transporter
MLA2C4_RS07670	COG1392	Phosphate transport regulator
MLA2C4_RS07675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLA2C4_RS07690	COG3852	Histidine kinase
MLA2C4_RS07695	COG1801	Protein of unknown function DUF72
MLA2C4_RS07705	COG0582	viral genome integration into host DNA
MLA2C4_RS07710	COG5002	protein histidine kinase activity
MLA2C4_RS07725	COG0392	lysyltransferase activity
MLA2C4_RS07725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MLA2C4_RS07740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MLA2C4_RS07745	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS07750	COG2715	membrane protein required for spore maturation
MLA2C4_RS07755	COG0700	Nucleoside recognition
MLA2C4_RS07760	COG1187	pseudouridine synthase activity
MLA2C4_RS07770	COG1333	cytochrome c biogenesis protein
MLA2C4_RS07775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MLA2C4_RS07780	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS07785	COG5002	protein histidine kinase activity
MLA2C4_RS07790	COG2096	Adenosyltransferase
MLA2C4_RS07795	COG1388	LysM domain
MLA2C4_RS07805	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MLA2C4_RS07810	COG1141	Ferredoxin
MLA2C4_RS07820	COG0514	ATP-dependent DNA helicase (RecQ)
MLA2C4_RS07825	COG1266	CAAX protease self-immunity
MLA2C4_RS07835	COG1408	metallophosphoesterase
MLA2C4_RS07845	COG4862	establishment of competence for transformation
MLA2C4_RS07850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MLA2C4_RS07870	COG0492	ferredoxin-NADP+ reductase activity
MLA2C4_RS07875	COG0252	asparaginase activity
MLA2C4_RS07915	COG1160	GTP binding
MLA2C4_RS07940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MLA2C4_RS07955	COG0142	geranyltranstransferase activity
MLA2C4_RS07965	COG0142	geranyltranstransferase activity
MLA2C4_RS07990	COG0457	Tetratricopeptide repeat
MLA2C4_RS08010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MLA2C4_RS08015	COG2010	Cytochrome c
MLA2C4_RS08015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MLA2C4_RS08020	COG4347	Protein of unknown function (DUF1405)
MLA2C4_RS08035	COG2738	Putative neutral zinc metallopeptidase
MLA2C4_RS08045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS08055	COG1694	Mazg nucleotide pyrophosphohydrolase
MLA2C4_RS08070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MLA2C4_RS08075	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS08110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MLA2C4_RS08110	COG1199	ATP-dependent helicase activity
MLA2C4_RS08130	COG3935	DnaD domain protein
MLA2C4_RS08135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MLA2C4_RS08145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLA2C4_RS08145	COG4499	WXG100 protein secretion system (Wss), protein YukC
MLA2C4_RS08200	COG0116	Belongs to the methyltransferase superfamily
MLA2C4_RS08210	COG1199	ATP-dependent helicase activity
MLA2C4_RS08215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MLA2C4_RS08225	COG0024	Methionine aminopeptidase
MLA2C4_RS08235	COG2233	PERMEase
MLA2C4_RS08240	COG2311	Membrane
MLA2C4_RS08245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MLA2C4_RS08255	COG0456	acetyltransferase
MLA2C4_RS08290	COG0754	glutathionylspermidine amidase activity
MLA2C4_RS08305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLA2C4_RS08340	COG0328	RNA-DNA hybrid ribonuclease activity
MLA2C4_RS08375	COG3403	YqcI/YcgG family
MLA2C4_RS08380	COG1280	lysine exporter protein (LysE YggA)
MLA2C4_RS08395	COG3162	membrane
MLA2C4_RS08400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLA2C4_RS08405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLA2C4_RS08415	COG0475	glutathione-regulated potassium exporter activity
MLA2C4_RS08420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MLA2C4_RS08425	COG0789	Transcriptional regulator
MLA2C4_RS08425	COG4978	Transcriptional regulator
MLA2C4_RS08435	COG2323	membrane
MLA2C4_RS08440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MLA2C4_RS08485	COG2814	Major facilitator Superfamily
MLA2C4_RS08505	COG1923	regulation of RNA biosynthetic process
MLA2C4_RS08515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MLA2C4_RS08520	COG1360	Flagellar Motor Protein
MLA2C4_RS08525	COG2201	protein-glutamate methylesterase activity
MLA2C4_RS08530	COG2198	Histidine kinase
MLA2C4_RS08530	COG0643	Histidine kinase
MLA2C4_RS08535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLA2C4_RS08535	COG1776	CheC inhibitor of MCP methylation
MLA2C4_RS08550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MLA2C4_RS08570	COG1256	bacterial-type flagellum assembly
MLA2C4_RS08575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MLA2C4_RS08580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MLA2C4_RS08595	COG1815	bacterial-type flagellum-dependent cell motility
MLA2C4_RS08600	COG1558	bacterial-type flagellum-dependent cell motility
MLA2C4_RS08610	COG1766	The M ring may be actively involved in energy transduction
MLA2C4_RS08615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLA2C4_RS08625	COG1157	protein secretion by the type III secretion system
MLA2C4_RS08645	COG1749	Flagellar hook protein flgE
MLA2C4_RS08660	COG0835	chemotaxis
MLA2C4_RS08660	COG0784	Response regulator, receiver
MLA2C4_RS08670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MLA2C4_RS08675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MLA2C4_RS08675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MLA2C4_RS08680	COG0741	lytic transglycosylase activity
MLA2C4_RS08690	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLA2C4_RS08695	COG1776	CheC inhibitor of MCP methylation
MLA2C4_RS08695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MLA2C4_RS08705	COG1338	Plays a role in the flagellum-specific transport system
MLA2C4_RS08710	COG1987	bacterial-type flagellum assembly
MLA2C4_RS08720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MLA2C4_RS08725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MLA2C4_RS08730	COG1419	protein localization to endoplasmic reticulum
MLA2C4_RS08735	COG4786	Flagellar basal body rod
MLA2C4_RS08740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLA2C4_RS08785	COG2329	Antibiotic biosynthesis monooxygenase
MLA2C4_RS08805	COG3764	Sortase (surface protein transpeptidase)
MLA2C4_RS08810	COG3764	Sortase (surface protein transpeptidase)
MLA2C4_RS08835	COG0583	DNA-binding transcription factor activity
MLA2C4_RS08840	COG3842	ATPase activity
MLA2C4_RS08845	COG0725	ABC transporter, periplasmic molybdate-binding protein
MLA2C4_RS08925	COG0367	asparagine synthase
MLA2C4_RS08955	COG1802	Transcriptional regulator
MLA2C4_RS08960	COG0697	spore germination
MLA2C4_RS08965	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS08965	COG1216	Glycosyl transferase, family 2
MLA2C4_RS08970	COG1757	Na H antiporter
MLA2C4_RS08975	COG0114	fumarate hydratase activity
MLA2C4_RS08990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS09000	COG0534	Mate efflux family protein
MLA2C4_RS09005	COG3340	Belongs to the peptidase S51 family
MLA2C4_RS09025	COG0785	Cytochrome C biogenesis protein
MLA2C4_RS09050	COG2733	membrane
MLA2C4_RS09090	COG1131	(ABC) transporter
MLA2C4_RS09110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLA2C4_RS09135	COG0528	UMP kinase activity
MLA2C4_RS09145	COG1027	Aspartate ammonia-lyase
MLA2C4_RS09150	COG0281	malic enzyme
MLA2C4_RS09155	COG4191	Histidine kinase
MLA2C4_RS09160	COG0784	Response regulator, receiver
MLA2C4_RS09165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MLA2C4_RS09225	COG1051	belongs to the nudix hydrolase family
MLA2C4_RS09230	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS09240	COG2814	Major facilitator Superfamily
MLA2C4_RS09255	COG3842	ATPase activity
MLA2C4_RS09260	COG2508	Transcriptional regulator
MLA2C4_RS09270	COG1175	transmembrane transport
MLA2C4_RS09275	COG0395	ABC-type sugar transport system, permease component
MLA2C4_RS09285	COG2188	Transcriptional regulator
MLA2C4_RS09290	COG2222	sugar isomerase
MLA2C4_RS09305	COG1105	Belongs to the carbohydrate kinase PfkB family
MLA2C4_RS09325	COG0477	Major facilitator Superfamily
MLA2C4_RS09330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLA2C4_RS09340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MLA2C4_RS09345	COG4166	transmembrane transport
MLA2C4_RS09350	COG2223	nitrite transmembrane transporter activity
MLA2C4_RS09355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLA2C4_RS09370	COG2244	polysaccharide biosynthetic process
MLA2C4_RS09375	COG0733	neurotransmitter:sodium symporter activity
MLA2C4_RS09390	COG2323	membrane
MLA2C4_RS09410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLA2C4_RS09415	COG2132	Multicopper oxidase
MLA2C4_RS09425	COG5002	protein histidine kinase activity
MLA2C4_RS09430	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS09440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLA2C4_RS09445	COG0028	Belongs to the TPP enzyme family
MLA2C4_RS09465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MLA2C4_RS09490	COG2814	Major facilitator Superfamily
MLA2C4_RS09495	COG3384	dioxygenase
MLA2C4_RS09510	COG3279	Response regulator of the LytR AlgR family
MLA2C4_RS09515	COG0427	acetyl-CoA hydrolase
MLA2C4_RS09535	COG1073	alpha beta
MLA2C4_RS09545	COG4166	transmembrane transport
MLA2C4_RS09550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS09570	COG1914	H( )-stimulated, divalent metal cation uptake system
MLA2C4_RS09585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MLA2C4_RS09590	COG0531	amino acid
MLA2C4_RS09615	COG2390	Transcriptional regulator
MLA2C4_RS09625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS09630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MLA2C4_RS09645	COG4846	Membrane protein involved in cytochrome C biogenesis
MLA2C4_RS09655	COG0006	proline dipeptidase activity
MLA2C4_RS09660	COG2132	Multicopper oxidase
MLA2C4_RS09675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MLA2C4_RS09700	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS09710	COG4641	Protein conserved in bacteria
MLA2C4_RS09720	COG2372	response to copper ion
MLA2C4_RS09720	COG1276	copper resistance
MLA2C4_RS09725	COG4549	nuclear export factor GLE1
MLA2C4_RS09730	COG0697	spore germination
MLA2C4_RS09735	COG0583	DNA-binding transcription factor activity
MLA2C4_RS09740	COG1959	2 iron, 2 sulfur cluster binding
MLA2C4_RS09745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MLA2C4_RS09750	COG0778	Nitroreductase
MLA2C4_RS09765	COG0628	permease
MLA2C4_RS09775	COG1231	oxidoreductase activity
MLA2C4_RS09780	COG0523	cobalamin synthesis protein
MLA2C4_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS09795	COG2030	dehydratase
MLA2C4_RS09800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLA2C4_RS09835	COG0583	DNA-binding transcription factor activity
MLA2C4_RS09845	COG1942	4-Oxalocrotonate Tautomerase
MLA2C4_RS09865	COG1271	oxidase subunit
MLA2C4_RS09870	COG1294	oxidase, subunit
MLA2C4_RS09875	COG4988	ABC transporter
MLA2C4_RS09880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MLA2C4_RS09885	COG1216	Glycosyl transferase, family 2
MLA2C4_RS09900	COG1619	proteins homologs of microcin C7 resistance protein MccF
MLA2C4_RS09905	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS09920	COG1388	LysM domain
MLA2C4_RS09920	COG0791	NLP P60 protein
MLA2C4_RS09930	COG1132	(ABC) transporter
MLA2C4_RS09935	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS09940	COG5002	protein histidine kinase activity
MLA2C4_RS09945	COG2205	protein histidine kinase activity
MLA2C4_RS09950	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS09975	COG0300	oxidoreductase activity
MLA2C4_RS09980	COG4122	O-methyltransferase activity
MLA2C4_RS10000	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MLA2C4_RS10010	COG0460	homoserine dehydrogenase
MLA2C4_RS10035	COG1316	TRANSCRIPTIONal
MLA2C4_RS10045	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS10050	COG5002	protein histidine kinase activity
MLA2C4_RS10065	COG1285	pathogenesis
MLA2C4_RS10070	COG1247	-acetyltransferase
MLA2C4_RS10090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLA2C4_RS10105	COG1082	Xylose isomerase domain protein TIM barrel
MLA2C4_RS10115	COG2814	Major facilitator Superfamily
MLA2C4_RS10120	COG1279	arginine transmembrane transporter activity
MLA2C4_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS10135	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLA2C4_RS10170	COG0577	efflux transmembrane transporter activity
MLA2C4_RS10175	COG2002	toxin-antitoxin pair type II binding
MLA2C4_RS10180	COG1404	Belongs to the peptidase S8 family
MLA2C4_RS10185	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MLA2C4_RS10190	COG0640	Transcriptional regulator
MLA2C4_RS10195	COG0667	Aldo Keto reductase
MLA2C4_RS10200	COG2814	Major facilitator Superfamily
MLA2C4_RS10230	COG0840	transmembrane signaling receptor activity
MLA2C4_RS10245	COG3949	Membrane
MLA2C4_RS10250	COG0783	Belongs to the Dps family
MLA2C4_RS10265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLA2C4_RS10280	COG1231	oxidoreductase activity
MLA2C4_RS10285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS10290	COG4989	oxidoreductase activity
MLA2C4_RS10295	COG0523	cobalamin synthesis protein
MLA2C4_RS10300	COG0456	acetyltransferase
MLA2C4_RS10305	COG3443	Belongs to the bacterial solute-binding protein 9 family
MLA2C4_RS10305	COG0803	Belongs to the bacterial solute-binding protein 9 family
MLA2C4_RS10310	COG0702	epimerase
MLA2C4_RS10320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MLA2C4_RS10330	COG4166	transmembrane transport
MLA2C4_RS10345	COG0406	alpha-ribazole phosphatase activity
MLA2C4_RS10355	COG5337	Spore coat protein CotH
MLA2C4_RS10360	COG1051	belongs to the nudix hydrolase family
MLA2C4_RS10365	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS10370	COG2244	polysaccharide biosynthetic process
MLA2C4_RS10380	COG0701	Predicted permease
MLA2C4_RS10385	COG3689	TIGRFAM TIGR03943 family protein
MLA2C4_RS10390	COG1607	acyl-coa hydrolase
MLA2C4_RS10415	COG0702	epimerase
MLA2C4_RS10420	COG2839	Protein conserved in bacteria
MLA2C4_RS10425	COG1253	flavin adenine dinucleotide binding
MLA2C4_RS10440	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS10445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLA2C4_RS10465	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS10475	COG1876	peptidase activity
MLA2C4_RS10480	COG0494	nUDIX hydrolase
MLA2C4_RS10490	COG0154	amidase activity
MLA2C4_RS10495	COG2211	Major facilitator Superfamily
MLA2C4_RS10550	COG0561	phosphatase activity
MLA2C4_RS10560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MLA2C4_RS10580	COG1819	glycosyl
MLA2C4_RS10585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS10590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS10620	COG0456	acetyltransferase
MLA2C4_RS10685	COG3874	Sporulation protein YtfJ
MLA2C4_RS10710	COG2226	methyltransferase
MLA2C4_RS10730	COG1082	Xylose isomerase domain protein TIM barrel
MLA2C4_RS10735	COG0346	lactoylglutathione lyase activity
MLA2C4_RS10745	COG0604	alcohol dehydrogenase
MLA2C4_RS10750	COG1595	DNA-templated transcription, initiation
MLA2C4_RS10775	COG0426	domain, Protein
MLA2C4_RS10775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MLA2C4_RS10785	COG0386	Belongs to the glutathione peroxidase family
MLA2C4_RS10790	COG1305	Transglutaminase-like
MLA2C4_RS10795	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MLA2C4_RS10800	COG0714	Associated with various cellular activities
MLA2C4_RS10805	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MLA2C4_RS10840	COG2359	stage V sporulation protein S
MLA2C4_RS10850	COG2856	Zn peptidase
MLA2C4_RS10860	COG0582	viral genome integration into host DNA
MLA2C4_RS10920	COG0457	Tetratricopeptide repeat
MLA2C4_RS10935	COG1418	mRNA catabolic process
MLA2C4_RS10940	COG0488	(ABC) transporter
MLA2C4_RS10955	COG0629	single-stranded DNA binding
MLA2C4_RS10960	COG1413	lyase activity
MLA2C4_RS10975	COG2521	methyltransferase
MLA2C4_RS10975	COG2136	Putative SAM-dependent methyltransferase
MLA2C4_RS10980	COG0018	arginyl-trna synthetase
MLA2C4_RS11010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MLA2C4_RS11015	COG0017	Asparaginyl-tRNA synthetase
MLA2C4_RS11035	COG1674	ftsk spoiiie
MLA2C4_RS11085	COG0733	neurotransmitter:sodium symporter activity
MLA2C4_RS11105	COG2610	gluconate transmembrane transporter activity
MLA2C4_RS11110	COG1454	alcohol dehydrogenase
MLA2C4_RS11115	COG1794	racemase activity, acting on amino acids and derivatives
MLA2C4_RS11125	COG0456	acetyltransferase
MLA2C4_RS11130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MLA2C4_RS11140	COG1131	(ABC) transporter
MLA2C4_RS11145	COG4473	ABC transporter
MLA2C4_RS11155	COG0546	phosphoglycolate phosphatase activity
MLA2C4_RS11180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MLA2C4_RS11200	COG0768	penicillin binding
MLA2C4_RS11210	COG0204	Acyl-transferase
MLA2C4_RS11215	COG1272	protein, Hemolysin III
MLA2C4_RS11225	COG0805	protein transport
MLA2C4_RS11235	COG1307	EDD domain protein, DegV family
MLA2C4_RS11245	COG1999	signal sequence binding
MLA2C4_RS11250	COG0071	Belongs to the small heat shock protein (HSP20) family
MLA2C4_RS11255	COG0367	asparagine synthase
MLA2C4_RS11275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS11280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MLA2C4_RS11300	COG1335	isochorismatase
MLA2C4_RS11305	COG0668	transmembrane transport
MLA2C4_RS11310	COG4585	Histidine kinase
MLA2C4_RS11310	COG2203	Gaf domain
MLA2C4_RS11315	COG2197	response regulator
MLA2C4_RS11320	COG1737	Transcriptional regulator
MLA2C4_RS11325	COG1064	alcohol dehydrogenase
MLA2C4_RS11345	COG1522	sequence-specific DNA binding
MLA2C4_RS11350	COG1070	Carbohydrate kinase
MLA2C4_RS11360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MLA2C4_RS11395	COG0517	IMP dehydrogenase activity
MLA2C4_RS11395	COG1125	glycine betaine transport
MLA2C4_RS11400	COG1174	glycine betaine transport
MLA2C4_RS11435	COG1253	flavin adenine dinucleotide binding
MLA2C4_RS11440	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS11445	COG5506	Protein of unknown function (DUF1694)
MLA2C4_RS11460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLA2C4_RS11465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MLA2C4_RS11470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MLA2C4_RS11475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLA2C4_RS11480	COG0456	acetyltransferase
MLA2C4_RS11485	COG3829	transcription factor binding
MLA2C4_RS11490	COG1509	lysine 2,3-aminomutase activity
MLA2C4_RS11525	COG4991	sh3 domain protein
MLA2C4_RS11525	COG3064	Membrane
MLA2C4_RS11525	COG0515	serine threonine protein kinase
MLA2C4_RS11530	COG4326	sporulation control protein
MLA2C4_RS11535	COG0671	phosphoesterase, PA-phosphatase related
MLA2C4_RS11540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MLA2C4_RS11545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLA2C4_RS11550	COG0582	viral genome integration into host DNA
MLA2C4_RS11575	COG1396	sequence-specific DNA binding
MLA2C4_RS11645	COG5582	Belongs to the UPF0302 family
MLA2C4_RS11650	COG2002	toxin-antitoxin pair type II binding
MLA2C4_RS11765	COG5484	DNA packaging
MLA2C4_RS11765	COG3728	DNA packaging
MLA2C4_RS11770	COG1783	phage Terminase large subunit
MLA2C4_RS11920	COG1787	Restriction endonuclease
MLA2C4_RS11920	COG1715	Restriction endonuclease
MLA2C4_RS12025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MLA2C4_RS12065	COG0300	oxidoreductase activity
MLA2C4_RS12085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLA2C4_RS12085	COG4499	WXG100 protein secretion system (Wss), protein YukC
MLA2C4_RS12095	COG2814	Major facilitator Superfamily
MLA2C4_RS12105	COG0372	Belongs to the citrate synthase family
MLA2C4_RS12110	COG2079	MmgE PrpD family protein
MLA2C4_RS12115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MLA2C4_RS12120	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS12125	COG2084	Dehydrogenase
MLA2C4_RS12135	COG1280	lysine exporter protein (LysE YggA)
MLA2C4_RS12140	COG1024	Enoyl-CoA hydratase
MLA2C4_RS12155	COG0420	3'-5' exonuclease activity
MLA2C4_RS12180	COG2223	nitrite transmembrane transporter activity
MLA2C4_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS12190	COG1169	isochorismate synthase
MLA2C4_RS12195	COG1021	2,3-dihydroxybenzoate-AMP ligase
MLA2C4_RS12200	COG1535	isochorismatase
MLA2C4_RS12200	COG3433	isochorismatase activity
MLA2C4_RS12205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MLA2C4_RS12210	COG3251	PFAM MbtH domain protein
MLA2C4_RS12215	COG2814	Major facilitator Superfamily
MLA2C4_RS12230	COG0776	regulation of translation
MLA2C4_RS12240	COG2318	DinB family
MLA2C4_RS12245	COG1115	amino acid carrier protein
MLA2C4_RS12260	COG2329	Antibiotic biosynthesis monooxygenase
MLA2C4_RS12265	COG1187	pseudouridine synthase activity
MLA2C4_RS12270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MLA2C4_RS12275	COG1136	(ABC) transporter
MLA2C4_RS12285	COG0596	Alpha beta hydrolase
MLA2C4_RS12290	COG2814	Major facilitator Superfamily
MLA2C4_RS12315	COG0028	Belongs to the TPP enzyme family
MLA2C4_RS12325	COG2226	methyltransferase
MLA2C4_RS12330	COG1234	tRNA 3'-trailer cleavage
MLA2C4_RS12355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLA2C4_RS12370	COG1846	Transcriptional regulator
MLA2C4_RS12405	COG1247	-acetyltransferase
MLA2C4_RS12435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MLA2C4_RS12445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS12455	COG1278	Cold shock
MLA2C4_RS12470	COG0010	Belongs to the arginase family
MLA2C4_RS12480	COG0583	DNA-binding transcription factor activity
MLA2C4_RS12485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MLA2C4_RS12500	COG0583	DNA-binding transcription factor activity
MLA2C4_RS12505	COG2258	MOSC domain
MLA2C4_RS12515	COG1132	(ABC) transporter
MLA2C4_RS12520	COG1132	(ABC) transporter
MLA2C4_RS12560	COG1396	sequence-specific DNA binding
MLA2C4_RS12595	COG4824	toxin secretion phage lysis holin
MLA2C4_RS12650	COG1476	TRANSCRIPTIONal
MLA2C4_RS12715	COG1233	COG1233 Phytoene dehydrogenase and related
MLA2C4_RS12720	COG1595	DNA-templated transcription, initiation
MLA2C4_RS12740	COG1649	PFAM Uncharacterised BCR, COG1649
MLA2C4_RS12760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MLA2C4_RS12765	COG2971	BadF BadG BcrA BcrD
MLA2C4_RS12785	COG1846	Transcriptional regulator
MLA2C4_RS12875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLA2C4_RS12875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLA2C4_RS12940	COG2002	toxin-antitoxin pair type II binding
MLA2C4_RS12955	COG0515	serine threonine protein kinase
MLA2C4_RS12955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MLA2C4_RS12970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MLA2C4_RS13100	COG5632	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS13115	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS13185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS13230	COG1309	transcriptional regulator
MLA2C4_RS13245	COG0577	efflux transmembrane transporter activity
MLA2C4_RS13245	COG1136	(ABC) transporter
MLA2C4_RS13250	COG3615	Tellurite resistance protein tehB
MLA2C4_RS13250	COG0500	methyltransferase
MLA2C4_RS13260	COG3961	Belongs to the TPP enzyme family
MLA2C4_RS13265	COG1846	Transcriptional regulator
MLA2C4_RS13295	COG2195	Cleaves the N-terminal amino acid of tripeptides
MLA2C4_RS13315	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS13330	COG0768	penicillin binding
MLA2C4_RS13335	COG1595	DNA-templated transcription, initiation
MLA2C4_RS13345	COG0768	penicillin binding
MLA2C4_RS13350	COG0768	penicillin binding
MLA2C4_RS13360	COG1609	Transcriptional regulator
MLA2C4_RS13365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MLA2C4_RS13370	COG0561	phosphatase activity
MLA2C4_RS13375	COG0673	inositol 2-dehydrogenase activity
MLA2C4_RS13380	COG0738	Major facilitator superfamily
MLA2C4_RS13415	COG1252	NADH dehydrogenase
MLA2C4_RS13435	COG1131	(ABC) transporter
MLA2C4_RS13445	COG1309	transcriptional regulator
MLA2C4_RS13460	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS13465	COG0439	Biotin carboxylase
MLA2C4_RS13470	COG0511	ligase activity, forming carbon-carbon bonds
MLA2C4_RS13475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MLA2C4_RS13480	COG1024	Enoyl-CoA hydratase
MLA2C4_RS13485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MLA2C4_RS13490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLA2C4_RS13505	COG0572	uridine kinase
MLA2C4_RS13515	COG2318	DinB family
MLA2C4_RS13520	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS13545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MLA2C4_RS13565	COG3227	Zinc metalloprotease (Elastase)
MLA2C4_RS13570	COG2207	Transcriptional regulator
MLA2C4_RS13615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MLA2C4_RS13620	COG0789	Transcriptional regulator
MLA2C4_RS13650	COG0693	protein deglycase activity
MLA2C4_RS13665	COG2814	Major facilitator Superfamily
MLA2C4_RS13670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MLA2C4_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS13685	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS13735	COG0697	spore germination
MLA2C4_RS13740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS13760	COG1063	alcohol dehydrogenase
MLA2C4_RS13765	COG2323	membrane
MLA2C4_RS13775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MLA2C4_RS13795	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MLA2C4_RS13800	COG3773	Cell wall hydrolase
MLA2C4_RS13810	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS13815	COG2205	protein histidine kinase activity
MLA2C4_RS13825	COG0583	DNA-binding transcription factor activity
MLA2C4_RS13830	COG0667	Aldo Keto reductase
MLA2C4_RS13835	COG0488	(ABC) transporter
MLA2C4_RS13850	COG1136	(ABC) transporter
MLA2C4_RS13855	COG0577	efflux transmembrane transporter activity
MLA2C4_RS13875	COG0460	homoserine dehydrogenase
MLA2C4_RS13880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS13890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MLA2C4_RS13940	COG4824	toxin secretion phage lysis holin
MLA2C4_RS14020	COG2124	cytochrome p450
MLA2C4_RS14060	COG0675	Transposase, IS605 OrfB family
MLA2C4_RS14070	COG0561	phosphatase activity
MLA2C4_RS14075	COG5002	protein histidine kinase activity
MLA2C4_RS14080	COG0768	penicillin binding
MLA2C4_RS14085	COG1819	glycosyl
MLA2C4_RS14090	COG1794	racemase activity, acting on amino acids and derivatives
MLA2C4_RS14115	COG2205	protein histidine kinase activity
MLA2C4_RS14125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MLA2C4_RS14130	COG0604	alcohol dehydrogenase
MLA2C4_RS14135	COG0671	phosphoesterase, PA-phosphatase related
MLA2C4_RS14140	COG0768	penicillin binding
MLA2C4_RS14180	COG0789	Transcriptional regulator
MLA2C4_RS14185	COG2814	Major facilitator Superfamily
MLA2C4_RS14190	COG0789	Transcriptional regulator
MLA2C4_RS14190	COG4978	Transcriptional regulator
MLA2C4_RS14225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS14230	COG0697	spore germination
MLA2C4_RS14255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MLA2C4_RS14260	COG2223	nitrite transmembrane transporter activity
MLA2C4_RS14280	COG2816	NAD+ diphosphatase activity
MLA2C4_RS14285	COG0592	DNA-directed DNA polymerase activity
MLA2C4_RS14290	COG1051	belongs to the nudix hydrolase family
MLA2C4_RS14310	COG3878	Protein conserved in bacteria
MLA2C4_RS14330	COG4667	esterase of the alpha-beta hydrolase superfamily
MLA2C4_RS14370	COG0322	excinuclease ABC activity
MLA2C4_RS14405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLA2C4_RS14430	COG1011	Hydrolase
MLA2C4_RS14435	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS14440	COG5002	protein histidine kinase activity
MLA2C4_RS14470	COG1136	(ABC) transporter
MLA2C4_RS14475	COG0577	efflux transmembrane transporter activity
MLA2C4_RS14490	COG1523	belongs to the glycosyl hydrolase 13 family
MLA2C4_RS14495	COG3227	Zinc metalloprotease (Elastase)
MLA2C4_RS14515	COG0201	protein transport
MLA2C4_RS14525	COG0697	spore germination
MLA2C4_RS14530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS14535	COG0604	alcohol dehydrogenase
MLA2C4_RS14570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS14585	COG2959	enzyme of heme biosynthesis
MLA2C4_RS14620	COG1309	transcriptional regulator
MLA2C4_RS14650	COG3284	Transcriptional regulator
MLA2C4_RS14660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS14665	COG1349	DNA-binding transcription factor activity
MLA2C4_RS14685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLA2C4_RS14690	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLA2C4_RS14695	COG0022	dehydrogenase e1 component
MLA2C4_RS14700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MLA2C4_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS14715	COG0456	acetyltransferase
MLA2C4_RS14715	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MLA2C4_RS14755	COG4176	ABC-type proline glycine betaine transport system permease component
MLA2C4_RS14760	COG4175	Glycine betaine
MLA2C4_RS14760	COG0517	IMP dehydrogenase activity
MLA2C4_RS14790	COG2153	protein acetylation
MLA2C4_RS14795	COG3397	chitin binding
MLA2C4_RS14800	COG1819	glycosyl
MLA2C4_RS14815	COG2205	protein histidine kinase activity
MLA2C4_RS14820	COG2226	methyltransferase
MLA2C4_RS14825	COG2315	Protein conserved in bacteria
MLA2C4_RS14830	COG2333	competence protein COMEC
MLA2C4_RS14830	COG0658	competence protein
MLA2C4_RS14880	COG3973	AAA domain
MLA2C4_RS14890	COG2105	PFAM AIG2 family protein
MLA2C4_RS14895	COG0514	ATP-dependent DNA helicase (RecQ)
MLA2C4_RS14920	COG4637	Psort location Cytoplasmic, score
MLA2C4_RS14945	COG3397	chitin binding
MLA2C4_RS14965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MLA2C4_RS14970	COG1115	amino acid carrier protein
MLA2C4_RS14975	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS14980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MLA2C4_RS14990	COG3938	Belongs to the proline racemase family
MLA2C4_RS14995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MLA2C4_RS15035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MLA2C4_RS15040	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS15050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MLA2C4_RS15070	COG4166	transmembrane transport
MLA2C4_RS15080	COG4948	Mandelate Racemase Muconate Lactonizing
MLA2C4_RS15130	COG2936	dipeptidyl-peptidase activity
MLA2C4_RS15165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MLA2C4_RS15170	COG1164	Oligoendopeptidase f
MLA2C4_RS15175	COG0531	amino acid
MLA2C4_RS15180	COG1522	sequence-specific DNA binding
MLA2C4_RS15185	COG1307	EDD domain protein, DegV family
MLA2C4_RS15240	COG2814	Major facilitator Superfamily
MLA2C4_RS15250	COG1664	Polymer-forming cytoskeletal
MLA2C4_RS15255	COG0789	Transcriptional regulator
MLA2C4_RS15260	COG4533	DNA binding
MLA2C4_RS15265	COG0477	Major facilitator Superfamily
MLA2C4_RS15265	COG2814	Major facilitator Superfamily
MLA2C4_RS15285	COG2261	transglycosylase associated protein
MLA2C4_RS15300	COG2226	methyltransferase
MLA2C4_RS15340	COG0436	Aminotransferase
MLA2C4_RS15345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MLA2C4_RS15355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MLA2C4_RS15370	COG1131	(ABC) transporter
MLA2C4_RS15415	COG0628	permease
MLA2C4_RS15425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MLA2C4_RS15430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLA2C4_RS15435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLA2C4_RS15450	COG2816	NAD+ diphosphatase activity
MLA2C4_RS15470	COG2746	aminoglycoside 3-N-acetyltransferase activity
MLA2C4_RS15490	COG0697	spore germination
MLA2C4_RS15495	COG2318	DinB family
MLA2C4_RS15500	COG0454	-acetyltransferase
MLA2C4_RS15525	COG0861	Integral membrane protein TerC family
MLA2C4_RS15530	COG1368	sulfuric ester hydrolase activity
MLA2C4_RS15535	COG0488	(ABC) transporter
MLA2C4_RS15540	COG2409	Drug exporters of the RND superfamily
MLA2C4_RS15540	COG1033	growth of symbiont in host cell
MLA2C4_RS15555	COG0287	Prephenate dehydrogenase
MLA2C4_RS15570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MLA2C4_RS15570	COG1605	Chorismate mutase
MLA2C4_RS15625	COG2610	gluconate transmembrane transporter activity
MLA2C4_RS15630	COG1024	Enoyl-CoA hydratase
MLA2C4_RS15640	COG3829	transcription factor binding
MLA2C4_RS15640	COG3290	protein histidine kinase activity
MLA2C4_RS15655	COG1879	ABC-type sugar transport system periplasmic component
MLA2C4_RS15660	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLA2C4_RS15665	COG1172	Belongs to the binding-protein-dependent transport system permease family
MLA2C4_RS15675	COG2390	Transcriptional regulator
MLA2C4_RS15680	COG1070	Carbohydrate kinase
MLA2C4_RS15715	COG2329	Antibiotic biosynthesis monooxygenase
MLA2C4_RS15730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS15745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MLA2C4_RS15750	COG4187	Peptidase family M20/M25/M40
MLA2C4_RS15755	COG1414	Transcriptional regulator
MLA2C4_RS15765	COG0833	amino acid
MLA2C4_RS15775	COG1690	Belongs to the RtcB family
MLA2C4_RS15780	COG3239	Fatty acid desaturase
MLA2C4_RS15790	COG1785	Belongs to the alkaline phosphatase family
MLA2C4_RS15800	COG3655	Transcriptional regulator
MLA2C4_RS15815	COG4377	Putative membrane peptidase family (DUF2324)
MLA2C4_RS15825	COG3279	Response regulator of the LytR AlgR family
MLA2C4_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS15845	COG0346	lactoylglutathione lyase activity
MLA2C4_RS15865	COG0714	Associated with various cellular activities
MLA2C4_RS15885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MLA2C4_RS15890	COG0753	catalase activity
MLA2C4_RS15925	COG0714	Associated with various cellular activities
MLA2C4_RS15940	COG0778	Nitroreductase
MLA2C4_RS15945	COG1846	Transcriptional regulator
MLA2C4_RS15985	COG1725	Transcriptional regulator
MLA2C4_RS16010	COG2207	Transcriptional regulator
MLA2C4_RS16015	COG0037	tRNA processing
MLA2C4_RS16015	COG0590	tRNA wobble adenosine to inosine editing
MLA2C4_RS16020	COG0456	acetyltransferase
MLA2C4_RS16040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS16065	COG0456	acetyltransferase
MLA2C4_RS16065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MLA2C4_RS16090	COG0730	response to heat
MLA2C4_RS16100	COG0833	amino acid
MLA2C4_RS16110	COG4335	DNA alkylation repair
MLA2C4_RS16125	COG0384	phenazine biosynthesis protein PhzF
MLA2C4_RS16145	COG0768	penicillin binding
MLA2C4_RS16180	COG1984	allophanate hydrolase subunit 2
MLA2C4_RS16185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MLA2C4_RS16190	COG1414	Transcriptional regulator
MLA2C4_RS16200	COG3142	Participates in the control of copper homeostasis
MLA2C4_RS16205	COG0860	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS16210	COG0640	Transcriptional regulator
MLA2C4_RS16225	COG0156	8-amino-7-oxononanoate synthase activity
MLA2C4_RS16230	COG2814	Major facilitator Superfamily
MLA2C4_RS16235	COG2226	methyltransferase
MLA2C4_RS16250	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS16265	COG3314	Sporulation integral membrane protein YlbJ
MLA2C4_RS16290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MLA2C4_RS16305	COG3848	Pyruvate phosphate dikinase
MLA2C4_RS16305	COG0574	Belongs to the PEP-utilizing enzyme family
MLA2C4_RS16310	COG1819	glycosyl
MLA2C4_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS16335	COG1063	alcohol dehydrogenase
MLA2C4_RS16345	COG1027	Aspartate ammonia-lyase
MLA2C4_RS16350	COG0252	asparaginase activity
MLA2C4_RS16355	COG1396	sequence-specific DNA binding
MLA2C4_RS16365	COG5002	protein histidine kinase activity
MLA2C4_RS16390	COG2207	Transcriptional regulator
MLA2C4_RS16405	COG0322	excinuclease ABC activity
MLA2C4_RS16410	COG0531	amino acid
MLA2C4_RS16415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MLA2C4_RS16425	COG0531	amino acid
MLA2C4_RS16430	COG0697	spore germination
MLA2C4_RS16440	COG0784	Response regulator, receiver
MLA2C4_RS16445	COG4191	Histidine kinase
MLA2C4_RS16450	COG2066	Belongs to the glutaminase family
MLA2C4_RS16460	COG1115	amino acid carrier protein
MLA2C4_RS16485	COG0737	Belongs to the 5'-nucleotidase family
MLA2C4_RS16490	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS16495	COG1335	isochorismatase
MLA2C4_RS16515	COG0583	DNA-binding transcription factor activity
MLA2C4_RS16570	COG0598	Magnesium transport protein CorA
MLA2C4_RS16625	COG0415	Belongs to the DNA photolyase family
MLA2C4_RS16640	COG0657	acetylesterase activity
MLA2C4_RS16645	COG0288	reversible hydration of carbon dioxide
MLA2C4_RS16655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MLA2C4_RS16660	COG5609	conserved protein (DUF2294)
MLA2C4_RS16685	COG1329	Transcriptional regulator
MLA2C4_RS16705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLA2C4_RS16715	COG1575	Belongs to the MenA family. Type 1 subfamily
MLA2C4_RS16725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MLA2C4_RS16740	COG4641	Protein conserved in bacteria
MLA2C4_RS16765	COG0798	PFAM Bile acid sodium symporter
MLA2C4_RS16770	COG0346	lactoylglutathione lyase activity
MLA2C4_RS16775	COG0640	Transcriptional regulator
MLA2C4_RS16795	COG0825	malonyl-CoA metabolic process
MLA2C4_RS16805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLA2C4_RS16805	COG3320	Male sterility
MLA2C4_RS16810	COG1309	transcriptional regulator
MLA2C4_RS16825	COG0346	lactoylglutathione lyase activity
MLA2C4_RS16850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS16860	COG2814	Major facilitator Superfamily
MLA2C4_RS16870	COG4895	conserved protein (DUF2196)
MLA2C4_RS16915	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS16920	COG5002	protein histidine kinase activity
MLA2C4_RS16920	COG3850	Histidine kinase
MLA2C4_RS16950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MLA2C4_RS16975	COG1476	TRANSCRIPTIONal
MLA2C4_RS16995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MLA2C4_RS17010	COG1136	(ABC) transporter
MLA2C4_RS17015	COG0577	efflux transmembrane transporter activity
MLA2C4_RS17035	COG5002	protein histidine kinase activity
MLA2C4_RS17035	COG3850	Histidine kinase
MLA2C4_RS17045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS17050	COG2271	Major facilitator Superfamily
MLA2C4_RS17055	COG1556	Lactate utilization protein
MLA2C4_RS17060	COG1139	Iron-sulfur cluster binding protein
MLA2C4_RS17070	COG0583	DNA-binding transcription factor activity
MLA2C4_RS17090	COG1619	proteins homologs of microcin C7 resistance protein MccF
MLA2C4_RS17110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MLA2C4_RS17180	COG5632	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS17180	COG3409	Peptidoglycan-binding domain 1 protein
MLA2C4_RS17190	COG2814	Major facilitator Superfamily
MLA2C4_RS17230	COG0477	Major facilitator Superfamily
MLA2C4_RS17245	COG1846	Transcriptional regulator
MLA2C4_RS17250	COG2814	Major facilitator Superfamily
MLA2C4_RS17260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MLA2C4_RS17265	COG1131	(ABC) transporter
MLA2C4_RS17290	COG2031	fatty acid transporter
MLA2C4_RS17300	COG2249	NAD(P)H dehydrogenase (quinone) activity
MLA2C4_RS17335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MLA2C4_RS17355	COG1288	antiporter activity
MLA2C4_RS17365	COG2814	Major facilitator Superfamily
MLA2C4_RS17370	COG1309	transcriptional regulator
MLA2C4_RS17375	COG0789	Transcriptional regulator
MLA2C4_RS17400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MLA2C4_RS17440	COG0583	DNA-binding transcription factor activity
MLA2C4_RS17460	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS17470	COG1131	(ABC) transporter
MLA2C4_RS17495	COG1011	Hydrolase
MLA2C4_RS17505	COG2365	Tyrosine phosphatase family
MLA2C4_RS17525	COG2816	NAD+ diphosphatase activity
MLA2C4_RS17530	COG0346	lactoylglutathione lyase activity
MLA2C4_RS17535	COG1940	carbohydrate kinase activity
MLA2C4_RS17550	COG0110	maltose O-acetyltransferase activity
MLA2C4_RS17560	COG1136	(ABC) transporter
MLA2C4_RS17560	COG0577	efflux transmembrane transporter activity
MLA2C4_RS17575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS17590	COG0628	permease
MLA2C4_RS17605	COG1720	tRNA m6t6A37 methyltransferase activity
MLA2C4_RS17610	COG0500	methyltransferase
MLA2C4_RS17620	COG0477	Major facilitator Superfamily
MLA2C4_RS17655	COG1253	flavin adenine dinucleotide binding
MLA2C4_RS17660	COG0789	Transcriptional regulator
MLA2C4_RS17670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MLA2C4_RS17695	COG0697	spore germination
MLA2C4_RS17700	COG1357	PFAM Pentapeptide repeats (8 copies)
MLA2C4_RS17705	COG3813	Protein conserved in bacteria
MLA2C4_RS17710	COG2706	6-phosphogluconolactonase activity
MLA2C4_RS17715	COG1070	Carbohydrate kinase
MLA2C4_RS17720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MLA2C4_RS17725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MLA2C4_RS17730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MLA2C4_RS17745	COG0814	amino acid
MLA2C4_RS17770	COG1393	Belongs to the ArsC family
MLA2C4_RS17780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS17815	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS17820	COG2249	NAD(P)H dehydrogenase (quinone) activity
MLA2C4_RS17825	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS17840	COG1191	sigma factor activity
MLA2C4_RS17860	COG1266	CAAX protease self-immunity
MLA2C4_RS17865	COG1309	transcriptional regulator
MLA2C4_RS17870	COG1280	lysine exporter protein (LysE YggA)
MLA2C4_RS17910	COG1151	hydroxylamine reductase activity
MLA2C4_RS17920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS17955	COG2072	flavoprotein involved in K transport
MLA2C4_RS17990	COG0604	alcohol dehydrogenase
MLA2C4_RS17995	COG1113	amino acid transport
MLA2C4_RS18000	COG2814	Major facilitator Superfamily
MLA2C4_RS18020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MLA2C4_RS18025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MLA2C4_RS18040	COG1131	(ABC) transporter
MLA2C4_RS18055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS18060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS18065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS18070	COG3739	integral membrane protein
MLA2C4_RS18090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS18105	COG0583	DNA-binding transcription factor activity
MLA2C4_RS18125	COG1193	negative regulation of DNA recombination
MLA2C4_RS18145	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MLA2C4_RS18150	COG1164	Oligoendopeptidase f
MLA2C4_RS18155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MLA2C4_RS18185	COG0584	glycerophosphoryl diester phosphodiesterase
MLA2C4_RS18195	COG0640	Transcriptional regulator
MLA2C4_RS18200	COG0604	alcohol dehydrogenase
MLA2C4_RS18210	COG0457	Tetratricopeptide repeat
MLA2C4_RS18220	COG2808	Putative FMN-binding domain
MLA2C4_RS18225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MLA2C4_RS18235	COG0385	Bile acid
MLA2C4_RS18240	COG0277	FAD linked oxidase domain protein
MLA2C4_RS18255	COG3300	MHYT domain
MLA2C4_RS18255	COG5001	Diguanylate cyclase
MLA2C4_RS18260	COG0488	(ABC) transporter
MLA2C4_RS18265	COG1309	transcriptional regulator
MLA2C4_RS18300	COG1285	pathogenesis
MLA2C4_RS18320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLA2C4_RS18330	COG2514	catechol 2,3-dioxygenase activity
MLA2C4_RS18335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS18340	COG1126	abc transporter atp-binding protein
MLA2C4_RS18345	COG0765	amino acid transport
MLA2C4_RS18350	COG2720	vancomycin resistance protein
MLA2C4_RS18385	COG0716	FMN binding
MLA2C4_RS18395	COG0494	nUDIX hydrolase
MLA2C4_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS18425	COG0165	Argininosuccinate lyase
MLA2C4_RS18440	COG4145	pantothenate transmembrane transporter activity
MLA2C4_RS18450	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS18465	COG1657	PFAM Prenyltransferase squalene oxidase
MLA2C4_RS18470	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MLA2C4_RS18475	COG2962	Rard protein
MLA2C4_RS18480	COG3326	Membrane
MLA2C4_RS18495	COG0489	protein tyrosine kinase activity
MLA2C4_RS18505	COG0314	molybdopterin synthase activity
MLA2C4_RS18510	COG0303	'Molybdopterin
MLA2C4_RS18515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLA2C4_RS18520	COG2116	formate transmembrane transporter activity
MLA2C4_RS18530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MLA2C4_RS18535	COG5609	conserved protein (DUF2294)
MLA2C4_RS18540	COG2427	Protein of unknown function (DUF1641)
MLA2C4_RS18545	COG3383	formate dehydrogenase (NAD+) activity
MLA2C4_RS18585	COG2226	methyltransferase
MLA2C4_RS18595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MLA2C4_RS18600	COG4166	transmembrane transport
MLA2C4_RS18605	COG4166	transmembrane transport
MLA2C4_RS18610	COG1301	dicarboxylic acid transport
MLA2C4_RS18615	COG1316	TRANSCRIPTIONal
MLA2C4_RS18625	COG1595	DNA-templated transcription, initiation
MLA2C4_RS18630	COG0346	lactoylglutathione lyase activity
MLA2C4_RS18640	COG1131	(ABC) transporter
MLA2C4_RS18675	COG0673	inositol 2-dehydrogenase activity
MLA2C4_RS18680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MLA2C4_RS18685	COG0187	DNA topoisomerase II activity
MLA2C4_RS18690	COG1832	CoA-binding protein
MLA2C4_RS18695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLA2C4_RS18700	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS18720	COG4841	protein insertion into membrane
MLA2C4_RS18725	COG0824	Thioesterase
MLA2C4_RS18790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLA2C4_RS18800	COG2274	protein secretion by the type I secretion system
MLA2C4_RS18805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MLA2C4_RS18835	COG2211	Major facilitator Superfamily
MLA2C4_RS18845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MLA2C4_RS18860	COG0183	Belongs to the thiolase family
MLA2C4_RS18865	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS18870	COG1268	BioY protein
MLA2C4_RS18875	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS18915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS18925	COG5002	protein histidine kinase activity
MLA2C4_RS18930	COG0400	carboxylic ester hydrolase activity
MLA2C4_RS18935	COG0346	lactoylglutathione lyase activity
MLA2C4_RS18940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MLA2C4_RS18945	COG0069	glutamate synthase activity
MLA2C4_RS18950	COG1902	pentaerythritol trinitrate reductase activity
MLA2C4_RS18955	COG1329	Transcriptional regulator
MLA2C4_RS18960	COG0010	Belongs to the arginase family
MLA2C4_RS18985	COG2226	methyltransferase
MLA2C4_RS19025	COG3344	reverse transcriptase
MLA2C4_RS19035	COG4846	Membrane protein involved in cytochrome C biogenesis
MLA2C4_RS19040	COG0785	Cytochrome C biogenesis protein
MLA2C4_RS19065	COG1473	amidohydrolase
MLA2C4_RS19075	COG1131	(ABC) transporter
MLA2C4_RS19090	COG0583	DNA-binding transcription factor activity
MLA2C4_RS19100	COG1346	cytolysis
MLA2C4_RS19120	COG5632	N-Acetylmuramoyl-L-alanine amidase
MLA2C4_RS19120	COG3409	Peptidoglycan-binding domain 1 protein
MLA2C4_RS19140	COG1132	(ABC) transporter
MLA2C4_RS19145	COG1132	(ABC) transporter
MLA2C4_RS19150	COG3763	UPF0154 protein
MLA2C4_RS19175	COG3639	organic phosphonate transmembrane transporter activity
MLA2C4_RS19185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS19190	COG0737	Belongs to the 5'-nucleotidase family
MLA2C4_RS19200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MLA2C4_RS19220	COG1695	Transcriptional regulator
MLA2C4_RS19225	COG1132	(ABC) transporter
MLA2C4_RS19255	COG0367	asparagine synthase
MLA2C4_RS19260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MLA2C4_RS19270	COG1181	Belongs to the D-alanine--D-alanine ligase family
MLA2C4_RS19275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MLA2C4_RS19310	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS19320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MLA2C4_RS19320	COG0463	Glycosyl transferase, family 2
MLA2C4_RS19325	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS19330	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS19335	COG1086	Polysaccharide biosynthesis protein
MLA2C4_RS19340	COG0489	protein tyrosine kinase activity
MLA2C4_RS19345	COG3944	biosynthesis protein
MLA2C4_RS19350	COG0174	glutamine synthetase
MLA2C4_RS19355	COG0789	Transcriptional regulator
MLA2C4_RS19360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MLA2C4_RS19365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MLA2C4_RS19370	COG2860	membrane
MLA2C4_RS19375	COG0464	growth
MLA2C4_RS19405	COG1388	LysM domain
MLA2C4_RS19405	COG3584	3D domain protein
MLA2C4_RS19410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MLA2C4_RS19410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MLA2C4_RS19410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLA2C4_RS19415	COG1105	Belongs to the carbohydrate kinase PfkB family
MLA2C4_RS19420	COG1349	DNA-binding transcription factor activity
MLA2C4_RS19425	COG1979	alcohol dehydrogenase
MLA2C4_RS19430	COG2322	membrane
MLA2C4_RS19440	COG1113	amino acid transport
MLA2C4_RS19455	COG1473	amidohydrolase
MLA2C4_RS19460	COG1408	metallophosphoesterase
MLA2C4_RS19465	COG2116	formate transmembrane transporter activity
MLA2C4_RS19475	COG0454	-acetyltransferase
MLA2C4_RS19480	COG2217	Heavy metal translocating P-type atpase
MLA2C4_RS19485	COG2608	mercury ion transmembrane transporter activity
MLA2C4_RS19490	COG1937	Protein conserved in bacteria
MLA2C4_RS19500	COG2819	hydrolase of the alpha beta superfamily
MLA2C4_RS19505	COG1120	ATPase activity
MLA2C4_RS19510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS19515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS19520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS19530	COG0708	Exodeoxyribonuclease III
MLA2C4_RS19535	COG2169	Transcriptional regulator
MLA2C4_RS19540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MLA2C4_RS19545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MLA2C4_RS19555	COG2364	Membrane
MLA2C4_RS19575	COG0346	lactoylglutathione lyase activity
MLA2C4_RS19580	COG5001	Diguanylate cyclase
MLA2C4_RS19580	COG3300	MHYT domain
MLA2C4_RS19620	COG1346	cytolysis
MLA2C4_RS19630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MLA2C4_RS19640	COG2188	Transcriptional regulator
MLA2C4_RS19645	COG2723	6-phospho-beta-galactosidase activity
MLA2C4_RS19650	COG0823	Involved in the tonB-independent uptake of proteins
MLA2C4_RS19655	COG1404	Belongs to the peptidase S8 family
MLA2C4_RS19660	COG3773	Cell wall hydrolase
MLA2C4_RS19675	COG1368	sulfuric ester hydrolase activity
MLA2C4_RS19680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MLA2C4_RS19695	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MLA2C4_RS19720	COG4550	Control of competence regulator ComK, YlbF/YmcA
MLA2C4_RS19730	COG1013	pyruvate-flavodoxin oxidoreductase activity
MLA2C4_RS19735	COG0674	pyruvate-flavodoxin oxidoreductase activity
MLA2C4_RS19735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MLA2C4_RS19745	COG2359	stage V sporulation protein S
MLA2C4_RS19750	COG1692	metallophosphoesterase
MLA2C4_RS19780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MLA2C4_RS19785	COG1426	Protein conserved in bacteria
MLA2C4_RS19800	COG0300	oxidoreductase activity
MLA2C4_RS19805	COG0612	Peptidase, M16
MLA2C4_RS19810	COG0612	Peptidase, M16
MLA2C4_RS19815	COG1079	Belongs to the binding-protein-dependent transport system permease family
MLA2C4_RS19820	COG4603	Belongs to the binding-protein-dependent transport system permease family
MLA2C4_RS19825	COG3845	ABC transporter
MLA2C4_RS19830	COG1744	ABC transporter substrate-binding protein PnrA-like
MLA2C4_RS19835	COG2188	Transcriptional regulator
MLA2C4_RS19845	COG1674	ftsk spoiiie
MLA2C4_RS19855	COG0740	serine-type endopeptidase activity
MLA2C4_RS19860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MLA2C4_RS19870	COG0527	aspartate kinase activity
MLA2C4_RS19875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MLA2C4_RS19880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MLA2C4_RS19885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLA2C4_RS19890	COG1873	PFAM PRC-barrel domain
MLA2C4_RS19895	COG0612	Peptidase, M16
MLA2C4_RS19900	COG0726	polysaccharide deacetylase
MLA2C4_RS19915	COG0196	riboflavin kinase activity
MLA2C4_RS19930	COG1550	Protein conserved in bacteria
MLA2C4_RS19940	COG1358	cellular component organization or biogenesis
MLA2C4_RS19945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MLA2C4_RS19950	COG0195	Participates in both transcription termination and antitermination
MLA2C4_RS19970	COG0750	zinc metalloprotease
MLA2C4_RS19980	COG4589	Belongs to the CDS family
MLA2C4_RS20025	COG4974	Belongs to the 'phage' integrase family
MLA2C4_RS20035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MLA2C4_RS20040	COG0758	DNA mediated transformation
MLA2C4_RS20045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MLA2C4_RS20085	COG1837	Belongs to the UPF0109 family
MLA2C4_RS20095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MLA2C4_RS20105	COG0552	protein localization to endoplasmic reticulum
MLA2C4_RS20110	COG1196	nuclear chromosome segregation
MLA2C4_RS20120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MLA2C4_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS20130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MLA2C4_RS20145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MLA2C4_RS20150	COG1461	Dihydroxyacetone kinase
MLA2C4_RS20155	COG1302	Protein conserved in bacteria
MLA2C4_RS20170	COG1564	THIamine pyrophosphokinase
MLA2C4_RS20175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MLA2C4_RS20185	COG0515	serine threonine protein kinase
MLA2C4_RS20185	COG2815	serine threonine protein kinase
MLA2C4_RS20190	COG0631	protein serine/threonine phosphatase activity
MLA2C4_RS20195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MLA2C4_RS20200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MLA2C4_RS20200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MLA2C4_RS20215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MLA2C4_RS20220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MLA2C4_RS20225	COG1758	RNA polymerase activity
MLA2C4_RS20240	COG1561	YicC-like family, N-terminal region
MLA2C4_RS20245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MLA2C4_RS20265	COG0006	proline dipeptidase activity
MLA2C4_RS20285	COG3069	C4-dicarboxylate transmembrane transporter activity
MLA2C4_RS20345	COG0564	pseudouridine synthase activity
MLA2C4_RS20365	COG3599	regulation of cell shape
MLA2C4_RS20370	COG2302	S4 RNA-binding domain
MLA2C4_RS20375	COG0762	integral membrane protein
MLA2C4_RS20385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MLA2C4_RS20395	COG1873	PFAM PRC-barrel domain
MLA2C4_RS20400	COG1191	sigma factor activity
MLA2C4_RS20405	COG1191	sigma factor activity
MLA2C4_RS20415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MLA2C4_RS20420	COG0849	cell division
MLA2C4_RS20425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MLA2C4_RS20440	COG0772	Belongs to the SEDS family
MLA2C4_RS20455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MLA2C4_RS20460	COG0768	penicillin binding
MLA2C4_RS20465	COG0768	penicillin binding
MLA2C4_RS20470	COG4839	cell division protein FtsL
MLA2C4_RS20485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MLA2C4_RS20500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MLA2C4_RS20505	COG1399	metal-binding, possibly nucleic acid-binding protein
MLA2C4_RS20515	COG3480	Lon protease (S16) C-terminal proteolytic domain
MLA2C4_RS20520	COG1752	Esterase of the alpha-beta hydrolase superfamily
MLA2C4_RS20525	COG3314	Sporulation integral membrane protein YlbJ
MLA2C4_RS20535	COG0742	ribosomal rna small subunit methyltransferase
MLA2C4_RS20550	COG3679	Belongs to the UPF0342 family
MLA2C4_RS20555	COG0406	alpha-ribazole phosphatase activity
MLA2C4_RS20570	COG2340	Cysteine-rich secretory protein family
MLA2C4_RS20580	COG3336	cytochrome c oxidase
MLA2C4_RS20615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MLA2C4_RS20625	COG0772	Belongs to the SEDS family
MLA2C4_RS20630	COG4838	Belongs to the UPF0358 family
MLA2C4_RS20635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MLA2C4_RS20640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MLA2C4_RS20650	COG4896	Protein conserved in bacteria
MLA2C4_RS20665	COG1217	gtp-binding protein TYPA
MLA2C4_RS20675	COG0483	inositol monophosphate 1-phosphatase activity
MLA2C4_RS20695	COG1982	Orn Lys Arg decarboxylase major
MLA2C4_RS20755	COG0022	dehydrogenase e1 component
MLA2C4_RS20760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MLA2C4_RS20775	COG0561	phosphatase activity
MLA2C4_RS20790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MLA2C4_RS20795	COG0569	domain protein
MLA2C4_RS20815	COG0583	DNA-binding transcription factor activity
MLA2C4_RS20820	COG0517	IMP dehydrogenase activity
MLA2C4_RS20830	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MLA2C4_RS20835	COG4703	Protein of unknown function (DUF1797)
MLA2C4_RS20850	COG2200	EAL domain
MLA2C4_RS20855	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS20860	COG1408	metallophosphoesterase
MLA2C4_RS20875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MLA2C4_RS20905	COG0675	Transposase, IS605 OrfB family
MLA2C4_RS20915	COG2814	Major facilitator Superfamily
MLA2C4_RS20940	COG3209	COG3209 Rhs family protein
MLA2C4_RS20950	COG2205	protein histidine kinase activity
MLA2C4_RS20960	COG0436	Aminotransferase
MLA2C4_RS20965	COG1609	Transcriptional regulator
MLA2C4_RS20970	COG3833	ABC-type maltose transport systems, permease component
MLA2C4_RS20975	COG1175	transmembrane transport
MLA2C4_RS20980	COG2182	Extracellular solute-binding protein
MLA2C4_RS20990	COG0366	Alpha amylase catalytic
MLA2C4_RS20995	COG3842	ATPase activity
MLA2C4_RS21035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MLA2C4_RS21040	COG0183	Belongs to the thiolase family
MLA2C4_RS21075	COG1695	Transcriptional regulator
MLA2C4_RS21080	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS21100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MLA2C4_RS21105	COG0436	Aminotransferase
MLA2C4_RS21140	COG2084	Dehydrogenase
MLA2C4_RS21150	COG2199	diguanylate cyclase activity
MLA2C4_RS21155	COG0778	Nitroreductase
MLA2C4_RS21180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MLA2C4_RS21180	COG1263	PTS System
MLA2C4_RS21180	COG2190	(PTS) system
MLA2C4_RS21185	COG3711	transcriptional antiterminator
MLA2C4_RS21195	COG2188	Transcriptional regulator
MLA2C4_RS21205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MLA2C4_RS21235	COG1547	Domain of unknown function (DUF309)
MLA2C4_RS21240	COG0456	acetyltransferase
MLA2C4_RS21250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MLA2C4_RS21255	COG4086	secreted protein
MLA2C4_RS21260	COG0561	phosphatase activity
MLA2C4_RS21265	COG0697	spore germination
MLA2C4_RS21280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLA2C4_RS21305	COG0733	neurotransmitter:sodium symporter activity
MLA2C4_RS21325	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS21335	COG1725	Transcriptional regulator
MLA2C4_RS21340	COG1131	(ABC) transporter
MLA2C4_RS21360	COG1846	Transcriptional regulator
MLA2C4_RS21375	COG0598	Magnesium transport protein CorA
MLA2C4_RS21400	COG4974	Belongs to the 'phage' integrase family
MLA2C4_RS21410	COG0735	belongs to the Fur family
MLA2C4_RS21415	COG1300	Membrane
MLA2C4_RS21440	COG0667	Aldo Keto reductase
MLA2C4_RS21445	COG0656	L-ascorbic acid biosynthetic process
MLA2C4_RS21450	COG0456	acetyltransferase
MLA2C4_RS21450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MLA2C4_RS21460	COG1525	nuclease
MLA2C4_RS21460	COG4085	toxin activity
MLA2C4_RS21460	COG0737	Belongs to the 5'-nucleotidase family
MLA2C4_RS21470	COG0596	Alpha beta hydrolase
MLA2C4_RS21475	COG2056	Na+-H+ antiporter family
MLA2C4_RS21480	COG1609	Transcriptional regulator
MLA2C4_RS21485	COG0456	acetyltransferase
MLA2C4_RS21490	COG1073	alpha beta
MLA2C4_RS21510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLA2C4_RS21510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MLA2C4_RS21515	COG0307	riboflavin synthase, alpha
MLA2C4_RS21540	COG4106	trans-aconitate 2-methyltransferase activity
MLA2C4_RS21545	COG2226	methyltransferase
MLA2C4_RS21545	COG1073	alpha beta
MLA2C4_RS21560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MLA2C4_RS21570	COG1757	Na H antiporter
MLA2C4_RS21575	COG0737	Belongs to the 5'-nucleotidase family
MLA2C4_RS21585	COG1522	sequence-specific DNA binding
MLA2C4_RS21605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MLA2C4_RS21630	COG0300	oxidoreductase activity
MLA2C4_RS21635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS21640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MLA2C4_RS21645	COG1760	l-serine dehydratase
MLA2C4_RS21650	COG1760	l-serine dehydratase
MLA2C4_RS21675	COG1285	pathogenesis
MLA2C4_RS21690	COG2195	Cleaves the N-terminal amino acid of tripeptides
MLA2C4_RS21695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS21705	COG1376	ErfK ybiS ycfS ynhG family protein
MLA2C4_RS21710	COG4129	membrane
MLA2C4_RS21715	COG1126	abc transporter atp-binding protein
MLA2C4_RS21720	COG0765	amino acid transport
MLA2C4_RS21725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MLA2C4_RS21745	COG2323	membrane
MLA2C4_RS21750	COG0772	Belongs to the SEDS family
MLA2C4_RS21755	COG0508	dehydrogenase complex catalyzes the overall conversion of
MLA2C4_RS21760	COG0022	dehydrogenase e1 component
MLA2C4_RS21765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MLA2C4_RS21770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MLA2C4_RS21785	COG0280	phosphate acetyltransferase
MLA2C4_RS21795	COG3290	protein histidine kinase activity
MLA2C4_RS21795	COG3829	transcription factor binding
MLA2C4_RS21805	COG0584	glycerophosphoryl diester phosphodiesterase
MLA2C4_RS21810	COG3093	addiction module antidote protein HigA
MLA2C4_RS21820	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS21830	COG0750	zinc metalloprotease
MLA2C4_RS21835	COG0497	DNA recombination
MLA2C4_RS21845	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MLA2C4_RS21855	COG0142	geranyltranstransferase activity
MLA2C4_RS21880	COG1302	Protein conserved in bacteria
MLA2C4_RS21885	COG0439	Biotin carboxylase
MLA2C4_RS21890	COG0511	ligase activity, forming carbon-carbon bonds
MLA2C4_RS21935	COG3854	ATPases associated with a variety of cellular activities
MLA2C4_RS21960	COG0006	proline dipeptidase activity
MLA2C4_RS21975	COG3872	metal-dependent enzyme
MLA2C4_RS21985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MLA2C4_RS22020	COG0095	Lipoate-protein ligase
MLA2C4_RS22025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLA2C4_RS22035	COG1609	Transcriptional regulator
MLA2C4_RS22045	COG2076	Multidrug Resistance protein
MLA2C4_RS22050	COG2076	Multidrug Resistance protein
MLA2C4_RS22085	COG1131	(ABC) transporter
MLA2C4_RS22090	COG1725	Transcriptional regulator
MLA2C4_RS22105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MLA2C4_RS22120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MLA2C4_RS22175	COG4970	Tfp pilus assembly protein FimT
MLA2C4_RS22185	COG1459	type II secretion system
MLA2C4_RS22190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MLA2C4_RS22240	COG0646	methionine synthase
MLA2C4_RS22240	COG1410	methionine synthase
MLA2C4_RS22245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MLA2C4_RS22245	COG0646	methionine synthase
MLA2C4_RS22250	COG0626	cystathionine gamma-synthase activity
MLA2C4_RS22255	COG0626	cystathionine gamma-synthase activity
MLA2C4_RS22275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS22285	COG1940	carbohydrate kinase activity
MLA2C4_RS22290	COG4483	Protein conserved in bacteria
MLA2C4_RS22295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MLA2C4_RS22300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MLA2C4_RS22305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MLA2C4_RS22310	COG0704	Plays a role in the regulation of phosphate uptake
MLA2C4_RS22320	COG0581	inorganic phosphate transmembrane transporter activity
MLA2C4_RS22325	COG0573	inorganic phosphate transmembrane transporter activity
MLA2C4_RS22330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MLA2C4_RS22335	COG0768	penicillin binding
MLA2C4_RS22340	COG0477	Major facilitator Superfamily
MLA2C4_RS22345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MLA2C4_RS22370	COG0735	belongs to the Fur family
MLA2C4_RS22375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MLA2C4_RS22380	COG1121	(ABC) transporter
MLA2C4_RS22385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS22415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MLA2C4_RS22420	COG2384	SAM-dependent methyltransferase
MLA2C4_RS22425	COG2010	Cytochrome c
MLA2C4_RS22430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MLA2C4_RS22435	COG0358	DNA primase activity
MLA2C4_RS22445	COG0517	IMP dehydrogenase activity
MLA2C4_RS22460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MLA2C4_RS22465	COG0295	cytidine deaminase activity
MLA2C4_RS22470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MLA2C4_RS22480	COG1480	7TM receptor with intracellular HD hydrolase
MLA2C4_RS22485	COG1702	phosphate starvation-inducible protein PhoH
MLA2C4_RS22500	COG1610	YqeY-like protein
MLA2C4_RS22505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MLA2C4_RS22510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MLA2C4_RS22515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MLA2C4_RS22545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MLA2C4_RS22550	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS22575	COG1466	dna polymerase III delta subunit
MLA2C4_RS22585	COG0658	competence protein
MLA2C4_RS22585	COG2333	competence protein COMEC
MLA2C4_RS22590	COG2131	deaminase
MLA2C4_RS22595	COG1596	polysaccharide export
MLA2C4_RS22595	COG1555	photosystem II stabilization
MLA2C4_RS22600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MLA2C4_RS22605	COG2226	methyltransferase
MLA2C4_RS22610	COG0799	negative regulation of ribosome biogenesis
MLA2C4_RS22615	COG1713	HD superfamily hydrolase involved in NAD metabolism
MLA2C4_RS22625	COG1534	Rna-binding protein
MLA2C4_RS22635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MLA2C4_RS22640	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MLA2C4_RS22665	COG1595	DNA-templated transcription, initiation
MLA2C4_RS22675	COG2357	RelA SpoT domain protein
MLA2C4_RS22685	COG1785	Belongs to the alkaline phosphatase family
MLA2C4_RS22695	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS22730	COG1404	Belongs to the peptidase S8 family
MLA2C4_RS22735	COG3186	Phenylalanine-4-hydroxylase
MLA2C4_RS22745	COG2514	catechol 2,3-dioxygenase activity
MLA2C4_RS22750	COG2259	Doxx family
MLA2C4_RS22790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS22805	COG1012	belongs to the aldehyde dehydrogenase family
MLA2C4_RS22805	COG1454	alcohol dehydrogenase
MLA2C4_RS22810	COG0626	cystathionine gamma-synthase activity
MLA2C4_RS22815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MLA2C4_RS22840	COG0768	penicillin binding
MLA2C4_RS22855	COG0826	peptidase U32
MLA2C4_RS22860	COG0826	peptidase U32
MLA2C4_RS22865	COG4122	O-methyltransferase activity
MLA2C4_RS22870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MLA2C4_RS22880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MLA2C4_RS22900	COG0628	permease
MLA2C4_RS22920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MLA2C4_RS22935	COG1104	cysteine desulfurase activity
MLA2C4_RS22940	COG1959	2 iron, 2 sulfur cluster binding
MLA2C4_RS22945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MLA2C4_RS22960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MLA2C4_RS22980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MLA2C4_RS22990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MLA2C4_RS22990	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MLA2C4_RS22995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MLA2C4_RS23000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MLA2C4_RS23000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MLA2C4_RS23010	COG2244	polysaccharide biosynthetic process
MLA2C4_RS23015	COG2323	membrane
MLA2C4_RS23025	COG1862	Preprotein translocase
MLA2C4_RS23055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MLA2C4_RS23065	COG0697	spore germination
MLA2C4_RS23070	COG0640	Transcriptional regulator
MLA2C4_RS23095	COG0157	Belongs to the NadC ModD family
MLA2C4_RS23100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MLA2C4_RS23105	COG1104	cysteine desulfurase activity
MLA2C4_RS23110	COG1827	regulation of RNA biosynthetic process
MLA2C4_RS23115	COG2258	MOSC domain
MLA2C4_RS23120	COG0077	Prephenate dehydratase
MLA2C4_RS23125	COG0577	efflux transmembrane transporter activity
MLA2C4_RS23130	COG0577	efflux transmembrane transporter activity
MLA2C4_RS23135	COG1136	(ABC) transporter
MLA2C4_RS23140	COG5002	protein histidine kinase activity
MLA2C4_RS23145	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS23155	COG3290	protein histidine kinase activity
MLA2C4_RS23165	COG2868	ribosomal protein
MLA2C4_RS23175	COG1530	ribonuclease E activity
MLA2C4_RS23180	COG1994	Peptidase M50
MLA2C4_RS23185	COG0739	heme binding
MLA2C4_RS23190	COG2894	cell division
MLA2C4_RS23210	COG1077	Cell shape determining protein MreB Mrl
MLA2C4_RS23235	COG0285	dihydrofolate synthase activity
MLA2C4_RS23240	COG0525	valine-tRNA ligase activity
MLA2C4_RS23250	COG1388	LysM domain
MLA2C4_RS23260	COG0113	porphobilinogen synthase activity
MLA2C4_RS23265	COG1587	Uroporphyrinogen-III synthase
MLA2C4_RS23275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MLA2C4_RS23285	COG1846	Transcriptional regulator
MLA2C4_RS23290	COG1764	response to oxidative stress
MLA2C4_RS23305	COG0470	DNA polymerase III
MLA2C4_RS23305	COG1067	ATP-dependent peptidase activity
MLA2C4_RS23360	COG0622	Phosphoesterase
MLA2C4_RS23375	COG5401	PFAM Sporulation and spore germination
MLA2C4_RS23385	COG0477	Major facilitator Superfamily
MLA2C4_RS23395	COG1309	transcriptional regulator
MLA2C4_RS23405	COG2197	response regulator
MLA2C4_RS23410	COG2233	PERMEase
MLA2C4_RS23415	COG0402	S-adenosylhomocysteine deaminase activity
MLA2C4_RS23420	COG1983	PspC domain protein
MLA2C4_RS23425	COG1396	sequence-specific DNA binding
MLA2C4_RS23430	COG0697	spore germination
MLA2C4_RS23440	COG1959	2 iron, 2 sulfur cluster binding
MLA2C4_RS23445	COG1668	transmembrane transport
MLA2C4_RS23450	COG4152	abc transporter atp-binding protein
MLA2C4_RS23455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MLA2C4_RS23460	COG1360	Flagellar Motor Protein
MLA2C4_RS23465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MLA2C4_RS23470	COG1876	peptidase activity
MLA2C4_RS23475	COG0824	Thioesterase
MLA2C4_RS23480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MLA2C4_RS23485	COG1053	succinate dehydrogenase
MLA2C4_RS23490	COG2009	succinate dehydrogenase
MLA2C4_RS23495	COG1719	4-vinyl reductase, 4VR
MLA2C4_RS23505	COG3118	belongs to the thioredoxin family
MLA2C4_RS23510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MLA2C4_RS23515	COG2086	electron transfer activity
MLA2C4_RS23520	COG1024	Enoyl-CoA hydratase
MLA2C4_RS23525	COG1309	transcriptional regulator
MLA2C4_RS23530	COG0318	PFAM AMP-dependent synthetase and ligase
MLA2C4_RS23555	COG2318	DinB family
MLA2C4_RS23580	COG1131	(ABC) transporter
MLA2C4_RS23585	COG2205	protein histidine kinase activity
MLA2C4_RS23590	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS23595	COG4895	conserved protein (DUF2196)
MLA2C4_RS23600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MLA2C4_RS23610	COG4509	Sortase family
MLA2C4_RS23615	COG1120	ATPase activity
MLA2C4_RS23630	COG5386	Cell surface protein
MLA2C4_RS23635	COG5386	Cell surface protein
MLA2C4_RS23640	COG1114	Component of the transport system for branched-chain amino acids
MLA2C4_RS23645	COG1187	pseudouridine synthase activity
MLA2C4_RS23655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MLA2C4_RS23655	COG1796	DNA polymerase
MLA2C4_RS23660	COG1286	toxin biosynthetic process
MLA2C4_RS23705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MLA2C4_RS23715	COG1418	mRNA catabolic process
MLA2C4_RS23735	COG2814	Major facilitator Superfamily
MLA2C4_RS23740	COG1566	PFAM secretion protein HlyD family protein
MLA2C4_RS23745	COG1309	transcriptional regulator
MLA2C4_RS23750	COG1363	Peptidase, m42
MLA2C4_RS23760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MLA2C4_RS23775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MLA2C4_RS23785	COG1484	DNA-dependent DNA replication
MLA2C4_RS23790	COG3611	Membrane attachment protein
MLA2C4_RS23800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MLA2C4_RS23810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MLA2C4_RS23815	COG0237	dephospho-CoA kinase activity
MLA2C4_RS23820	COG1971	Probably functions as a manganese efflux pump
MLA2C4_RS23830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLA2C4_RS23830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MLA2C4_RS23835	COG5002	protein histidine kinase activity
MLA2C4_RS23840	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS23860	COG0538	isocitrate dehydrogenase activity
MLA2C4_RS23865	COG0372	Belongs to the citrate synthase family
MLA2C4_RS23880	COG0628	permease
MLA2C4_RS23885	COG3030	protein affecting phage T7 exclusion by the F plasmid
MLA2C4_RS23910	COG1725	Transcriptional regulator
MLA2C4_RS23915	COG0281	malic enzyme
MLA2C4_RS23920	COG0587	DNA-directed DNA polymerase activity
MLA2C4_RS23955	COG4109	DRTGG domain
MLA2C4_RS23965	COG0006	proline dipeptidase activity
MLA2C4_RS24005	COG0662	Cupin 2, conserved barrel domain protein
MLA2C4_RS24015	COG1476	TRANSCRIPTIONal
MLA2C4_RS24030	COG1028	Short-chain dehydrogenase reductase Sdr
MLA2C4_RS24035	COG0589	response to stress
MLA2C4_RS24075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS24095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MLA2C4_RS24100	COG0827	DNA restriction-modification system
MLA2C4_RS24105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MLA2C4_RS24110	COG3874	Sporulation protein YtfJ
MLA2C4_RS24125	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MLA2C4_RS24135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLA2C4_RS24150	COG1104	cysteine desulfurase activity
MLA2C4_RS24160	COG0583	DNA-binding transcription factor activity
MLA2C4_RS24165	COG0697	spore germination
MLA2C4_RS24170	COG1309	transcriptional regulator
MLA2C4_RS24175	COG1956	GAF domain-containing protein
MLA2C4_RS24185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MLA2C4_RS24210	COG1595	DNA-templated transcription, initiation
MLA2C4_RS24220	COG0110	maltose O-acetyltransferase activity
MLA2C4_RS24225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MLA2C4_RS24230	COG0454	-acetyltransferase
MLA2C4_RS24235	COG0517	IMP dehydrogenase activity
MLA2C4_RS24240	COG0123	including yeast histone deacetylase and acetoin utilization protein
MLA2C4_RS24260	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS24265	COG5002	protein histidine kinase activity
MLA2C4_RS24305	COG1609	Transcriptional regulator
MLA2C4_RS24315	COG4851	CamS sex pheromone cAM373 precursor
MLA2C4_RS24320	COG3118	belongs to the thioredoxin family
MLA2C4_RS24330	COG2309	aminopeptidase activity
MLA2C4_RS24355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS24360	COG0697	spore germination
MLA2C4_RS24365	COG0789	Transcriptional regulator
MLA2C4_RS24370	COG1695	Transcriptional regulator
MLA2C4_RS24390	COG1674	ftsk spoiiie
MLA2C4_RS24405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MLA2C4_RS24415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLA2C4_RS24420	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MLA2C4_RS24425	COG1363	Peptidase, m42
MLA2C4_RS24435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS24450	COG0510	thiamine kinase activity
MLA2C4_RS24455	COG1523	belongs to the glycosyl hydrolase 13 family
MLA2C4_RS24465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MLA2C4_RS24470	COG1349	DNA-binding transcription factor activity
MLA2C4_RS24475	COG1187	pseudouridine synthase activity
MLA2C4_RS24480	COG2244	polysaccharide biosynthetic process
MLA2C4_RS24485	COG2081	HI0933 family
MLA2C4_RS24490	COG2814	Major facilitator Superfamily
MLA2C4_RS24505	COG3832	glyoxalase III activity
MLA2C4_RS24530	COG1329	Transcriptional regulator
MLA2C4_RS24555	COG0314	molybdopterin synthase activity
MLA2C4_RS24560	COG1763	Mo-molybdopterin cofactor biosynthetic process
MLA2C4_RS24565	COG0303	'Molybdopterin
MLA2C4_RS24575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MLA2C4_RS24580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MLA2C4_RS24600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MLA2C4_RS24610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MLA2C4_RS24650	COG2814	Major facilitator Superfamily
MLA2C4_RS24655	COG0475	glutathione-regulated potassium exporter activity
MLA2C4_RS24660	COG0490	domain, Protein
MLA2C4_RS24665	COG0582	viral genome integration into host DNA
MLA2C4_RS24675	COG1136	(ABC) transporter
MLA2C4_RS24700	COG1242	4 iron, 4 sulfur cluster binding
MLA2C4_RS24705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MLA2C4_RS24710	COG1131	(ABC) transporter
MLA2C4_RS24720	COG1794	racemase activity, acting on amino acids and derivatives
MLA2C4_RS24730	COG1131	(ABC) transporter
MLA2C4_RS24770	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS24775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MLA2C4_RS24780	COG0671	phosphoesterase, PA-phosphatase related
MLA2C4_RS24785	COG0438	transferase activity, transferring glycosyl groups
MLA2C4_RS24795	COG0521	Mo-molybdopterin cofactor biosynthetic process
MLA2C4_RS24845	COG5002	protein histidine kinase activity
MLA2C4_RS24850	COG4191	Histidine kinase
MLA2C4_RS24855	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS24875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MLA2C4_RS24880	COG1116	anion transmembrane transporter activity
MLA2C4_RS24885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MLA2C4_RS24910	COG0494	nUDIX hydrolase
MLA2C4_RS24950	COG1854	S-ribosylhomocysteine lyase activity
MLA2C4_RS24960	COG0288	reversible hydration of carbon dioxide
MLA2C4_RS24965	COG1271	oxidase subunit
MLA2C4_RS24970	COG1294	oxidase, subunit
MLA2C4_RS24990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS25015	COG1842	Phage shock protein A
MLA2C4_RS25040	COG3859	Proton-coupled thiamine transporter YuaJ
MLA2C4_RS25045	COG5002	protein histidine kinase activity
MLA2C4_RS25050	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS25075	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MLA2C4_RS25080	COG1597	lipid kinase activity
MLA2C4_RS25120	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS25130	COG4977	sequence-specific DNA binding
MLA2C4_RS25140	COG0577	efflux transmembrane transporter activity
MLA2C4_RS25145	COG1136	(ABC) transporter
MLA2C4_RS25150	COG2207	Transcriptional regulator
MLA2C4_RS25150	COG3708	Transcriptional regulator
MLA2C4_RS25155	COG5658	integral membrane protein
MLA2C4_RS25160	COG0640	Transcriptional regulator
MLA2C4_RS25165	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS25170	COG2205	protein histidine kinase activity
MLA2C4_RS25175	COG0577	efflux transmembrane transporter activity
MLA2C4_RS25180	COG0577	efflux transmembrane transporter activity
MLA2C4_RS25185	COG1136	(ABC) transporter
MLA2C4_RS25190	COG0577	efflux transmembrane transporter activity
MLA2C4_RS25205	COG2188	Transcriptional regulator
MLA2C4_RS25225	COG3964	amidohydrolase
MLA2C4_RS25250	COG4948	Mandelate Racemase Muconate Lactonizing
MLA2C4_RS25260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MLA2C4_RS25265	COG0596	Alpha beta hydrolase
MLA2C4_RS25275	COG1169	isochorismate synthase
MLA2C4_RS25280	COG1575	Belongs to the MenA family. Type 1 subfamily
MLA2C4_RS25285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MLA2C4_RS25290	COG1278	Cold shock
MLA2C4_RS25305	COG0058	SHG alpha-glucan phosphorylase activity
MLA2C4_RS25315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MLA2C4_RS25325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MLA2C4_RS25335	COG1404	Belongs to the peptidase S8 family
MLA2C4_RS25350	COG1595	DNA-templated transcription, initiation
MLA2C4_RS25480	COG1285	pathogenesis
MLA2C4_RS25485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MLA2C4_RS25505	COG2155	Conserved Protein
MLA2C4_RS25510	COG1098	S1 RNA binding domain
MLA2C4_RS25515	COG0436	Aminotransferase
MLA2C4_RS25520	COG1522	sequence-specific DNA binding
MLA2C4_RS25525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MLA2C4_RS25530	COG2267	carboxylic ester hydrolase activity
MLA2C4_RS25540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MLA2C4_RS25555	COG5018	Exonuclease
MLA2C4_RS25560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MLA2C4_RS25580	COG2050	protein possibly involved in aromatic compounds catabolism
MLA2C4_RS25590	COG1268	BioY protein
MLA2C4_RS25600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MLA2C4_RS25605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MLA2C4_RS25620	COG3584	3D domain protein
MLA2C4_RS25635	COG1252	NADH dehydrogenase
MLA2C4_RS25645	COG3708	Transcriptional regulator
MLA2C4_RS25660	COG0583	DNA-binding transcription factor activity
MLA2C4_RS25665	COG2814	Major facilitator Superfamily
MLA2C4_RS25675	COG1683	Conserved Protein
MLA2C4_RS25685	COG4122	O-methyltransferase activity
MLA2C4_RS25700	COG0316	Belongs to the HesB IscA family
MLA2C4_RS25715	COG1252	NADH dehydrogenase
MLA2C4_RS25730	COG0390	transport system, permease component
MLA2C4_RS25735	COG2824	Alkylphosphonate utilization operon protein PhnA
MLA2C4_RS25755	COG4837	Protein of unknown function (DUF1462)
MLA2C4_RS25760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MLA2C4_RS25770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MLA2C4_RS25775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MLA2C4_RS25790	COG1136	(ABC) transporter
MLA2C4_RS25790	COG0577	efflux transmembrane transporter activity
MLA2C4_RS25795	COG2249	NAD(P)H dehydrogenase (quinone) activity
MLA2C4_RS25805	COG0647	UMP catabolic process
MLA2C4_RS25815	COG2445	Protein of unknown function DUF86
MLA2C4_RS25820	COG1494	fructose-1,6-bisphosphatase
MLA2C4_RS25835	COG0564	pseudouridine synthase activity
MLA2C4_RS25840	COG4470	Protein conserved in bacteria
MLA2C4_RS25850	COG0789	Transcriptional regulator
MLA2C4_RS25855	COG4377	Putative membrane peptidase family (DUF2324)
MLA2C4_RS25880	COG0739	heme binding
MLA2C4_RS25890	COG3377	Domain of unknown function (DUF1805)
MLA2C4_RS25895	COG0737	Belongs to the 5'-nucleotidase family
MLA2C4_RS25905	COG0719	Fe-S assembly protein
MLA2C4_RS25910	COG0822	iron-sulfur transferase activity
MLA2C4_RS25915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MLA2C4_RS25920	COG0719	Fe-S assembly protein
MLA2C4_RS25925	COG0396	ATPase activity
MLA2C4_RS25930	COG1464	Belongs to the NlpA lipoprotein family
MLA2C4_RS25935	COG1464	Belongs to the NlpA lipoprotein family
MLA2C4_RS25940	COG2011	ABC-type metal ion transport system permease component
MLA2C4_RS25955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MLA2C4_RS25960	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MLA2C4_RS25970	COG1393	Belongs to the ArsC family
MLA2C4_RS26020	COG1309	transcriptional regulator
MLA2C4_RS26025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MLA2C4_RS26030	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS26035	COG0183	Belongs to the thiolase family
MLA2C4_RS26040	COG1024	Enoyl-CoA hydratase
MLA2C4_RS26040	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLA2C4_RS26050	COG1686	Belongs to the peptidase S11 family
MLA2C4_RS26055	COG0506	proline dehydrogenase activity
MLA2C4_RS26065	COG0011	TIGRFAM Protein of
MLA2C4_RS26070	COG0840	transmembrane signaling receptor activity
MLA2C4_RS26110	COG4974	Belongs to the 'phage' integrase family
MLA2C4_RS26120	COG2814	Major facilitator Superfamily
MLA2C4_RS26125	COG0531	amino acid
MLA2C4_RS26150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MLA2C4_RS26190	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS26200	COG1376	ErfK ybiS ycfS ynhG family protein
MLA2C4_RS26205	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS26210	COG5002	protein histidine kinase activity
MLA2C4_RS26240	COG0840	transmembrane signaling receptor activity
MLA2C4_RS26245	COG2151	metal-sulfur cluster biosynthetic enzyme
MLA2C4_RS26250	COG3227	Zinc metalloprotease (Elastase)
MLA2C4_RS26255	COG1741	Belongs to the pirin family
MLA2C4_RS26270	COG0586	Pfam SNARE associated Golgi protein
MLA2C4_RS26275	COG0475	glutathione-regulated potassium exporter activity
MLA2C4_RS26280	COG0490	domain, Protein
MLA2C4_RS26285	COG1115	amino acid carrier protein
MLA2C4_RS26290	COG0783	Belongs to the Dps family
MLA2C4_RS26300	COG1611	Belongs to the LOG family
MLA2C4_RS26320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS26330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS26335	COG1115	amino acid carrier protein
MLA2C4_RS26340	COG1115	amino acid carrier protein
MLA2C4_RS26345	COG2910	NAD(P)H-binding
MLA2C4_RS26360	COG0656	L-ascorbic acid biosynthetic process
MLA2C4_RS26365	COG2814	Major facilitator Superfamily
MLA2C4_RS26370	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS26380	COG1252	NADH dehydrogenase
MLA2C4_RS26385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MLA2C4_RS26390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MLA2C4_RS26400	COG0840	transmembrane signaling receptor activity
MLA2C4_RS26400	COG3290	protein histidine kinase activity
MLA2C4_RS26435	COG0488	(ABC) transporter
MLA2C4_RS26440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MLA2C4_RS26450	COG1335	isochorismatase
MLA2C4_RS26455	COG1522	sequence-specific DNA binding
MLA2C4_RS26460	COG1522	sequence-specific DNA binding
MLA2C4_RS26465	COG0288	reversible hydration of carbon dioxide
MLA2C4_RS26470	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MLA2C4_RS26475	COG2233	PERMEase
MLA2C4_RS26510	COG0697	spore germination
MLA2C4_RS26535	COG0557	exoribonuclease II activity
MLA2C4_RS26540	COG1647	Serine aminopeptidase, S33
MLA2C4_RS26545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MLA2C4_RS26550	COG1346	cytolysis
MLA2C4_RS26565	COG0148	phosphopyruvate hydratase activity
MLA2C4_RS26585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MLA2C4_RS26600	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MLA2C4_RS26625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MLA2C4_RS26640	COG2323	membrane
MLA2C4_RS26650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLA2C4_RS26660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MLA2C4_RS26670	COG1051	belongs to the nudix hydrolase family
MLA2C4_RS26680	COG0492	ferredoxin-NADP+ reductase activity
MLA2C4_RS26685	COG0457	Tetratricopeptide repeat
MLA2C4_RS26690	COG0110	maltose O-acetyltransferase activity
MLA2C4_RS26710	COG1950	PFAM Membrane protein of
MLA2C4_RS26720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MLA2C4_RS26725	COG0556	nucleotide-excision repair
MLA2C4_RS26740	COG0789	Transcriptional regulator
MLA2C4_RS26775	COG0583	DNA-binding transcription factor activity
MLA2C4_RS26785	COG0655	NAD(P)H dehydrogenase (quinone) activity
MLA2C4_RS26790	COG0488	(ABC) transporter
MLA2C4_RS26800	COG1132	(ABC) transporter
MLA2C4_RS26805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLA2C4_RS26810	COG3409	Peptidoglycan-binding domain 1 protein
MLA2C4_RS26810	COG0793	Belongs to the peptidase S41A family
MLA2C4_RS26815	COG2177	Part of the ABC transporter FtsEX involved in
MLA2C4_RS26820	COG2884	Cell division ATP-binding protein ftsE
MLA2C4_RS26850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MLA2C4_RS26855	COG1278	Cold shock
MLA2C4_RS26860	COG1040	competence protein
MLA2C4_RS26865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MLA2C4_RS26870	COG1388	LysM domain
MLA2C4_RS26870	COG0791	NLP P60 protein
MLA2C4_RS26875	COG1733	regulation of RNA biosynthetic process
MLA2C4_RS26880	COG1307	EDD domain protein, DegV family
MLA2C4_RS26885	COG1739	Uncharacterized protein family UPF0029
MLA2C4_RS26890	COG1316	TRANSCRIPTIONal
MLA2C4_RS26895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MLA2C4_RS26900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MLA2C4_RS26905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MLA2C4_RS26915	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MLA2C4_RS26915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MLA2C4_RS26935	COG1486	melibiose metabolic process
MLA2C4_RS26940	COG1447	Phosphotransferase system cellobiose-specific component IIA
MLA2C4_RS26945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MLA2C4_RS26970	COG1447	Phosphotransferase system cellobiose-specific component IIA
MLA2C4_RS26980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MLA2C4_RS26985	COG1301	dicarboxylic acid transport
MLA2C4_RS26995	COG0346	lactoylglutathione lyase activity
MLA2C4_RS27000	COG1511	domain protein
MLA2C4_RS27005	COG0583	DNA-binding transcription factor activity
MLA2C4_RS27010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MLA2C4_RS27015	COG1271	oxidase subunit
MLA2C4_RS27020	COG1294	oxidase, subunit
MLA2C4_RS27025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MLA2C4_RS27035	COG1620	l-lactate permease
MLA2C4_RS27045	COG2389	metal-binding protein
MLA2C4_RS27060	COG1368	sulfuric ester hydrolase activity
MLA2C4_RS27070	COG0791	NLP P60 protein
MLA2C4_RS27070	COG1388	LysM domain
MLA2C4_RS27075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MLA2C4_RS27085	COG1215	transferase activity, transferring glycosyl groups
MLA2C4_RS27090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MLA2C4_RS27100	COG1388	LysM domain
MLA2C4_RS27100	COG3584	3D domain protein
MLA2C4_RS27125	COG4715	Zinc finger, swim domain protein
MLA2C4_RS27130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MLA2C4_RS27170	COG0577	efflux transmembrane transporter activity
MLA2C4_RS27175	COG1136	(ABC) transporter
MLA2C4_RS27200	COG5002	protein histidine kinase activity
MLA2C4_RS27205	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS27210	COG1482	cell wall glycoprotein biosynthetic process
MLA2C4_RS27215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLA2C4_RS27215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MLA2C4_RS27215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MLA2C4_RS27220	COG3711	transcriptional antiterminator
MLA2C4_RS27220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MLA2C4_RS27225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MLA2C4_RS27240	COG1482	cell wall glycoprotein biosynthetic process
MLA2C4_RS27250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MLA2C4_RS27250	COG0662	Cupin 2, conserved barrel domain protein
MLA2C4_RS27280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MLA2C4_RS27285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MLA2C4_RS27295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MLA2C4_RS27300	COG4464	protein tyrosine phosphatase activity
MLA2C4_RS27305	COG0489	protein tyrosine kinase activity
MLA2C4_RS27310	COG3944	biosynthesis protein
MLA2C4_RS27315	COG0489	protein tyrosine kinase activity
MLA2C4_RS27330	COG1609	Transcriptional regulator
MLA2C4_RS27340	COG0739	heme binding
MLA2C4_RS27355	COG3279	Response regulator of the LytR AlgR family
MLA2C4_RS27365	COG2385	sporulation resulting in formation of a cellular spore
MLA2C4_RS27380	COG4836	Membrane
MLA2C4_RS27385	COG1007	ATP synthesis coupled electron transport
MLA2C4_RS27390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLA2C4_RS27395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MLA2C4_RS27405	COG0839	Belongs to the complex I subunit 6 family
MLA2C4_RS27425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MLA2C4_RS27440	COG3300	MHYT domain
MLA2C4_RS27440	COG5001	Diguanylate cyclase
MLA2C4_RS27490	COG0356	it plays a direct role in the translocation of protons across the membrane
MLA2C4_RS27525	COG0698	ribose 5-phosphate isomerase
MLA2C4_RS27535	COG2190	(PTS) system
MLA2C4_RS27540	COG2259	Doxx family
MLA2C4_RS27545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MLA2C4_RS27565	COG0009	L-threonylcarbamoyladenylate synthase
MLA2C4_RS27580	COG2890	protein-(glutamine-N5) methyltransferase activity
MLA2C4_RS27585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MLA2C4_RS27595	COG1435	thymidine kinase activity
MLA2C4_RS27610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MLA2C4_RS27615	COG1494	fructose-1,6-bisphosphatase
MLA2C4_RS27635	COG4821	SIS domain
MLA2C4_RS27655	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS27660	COG1960	acyl-CoA dehydrogenase activity
MLA2C4_RS27665	COG1250	3-hydroxyacyl-CoA dehydrogenase
MLA2C4_RS27670	COG0183	Belongs to the thiolase family
MLA2C4_RS27675	COG2181	nitrate reductase activity
MLA2C4_RS27675	COG0247	lactate metabolic process
MLA2C4_RS27680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MLA2C4_RS27690	COG5001	Diguanylate cyclase
MLA2C4_RS27690	COG3300	MHYT domain
MLA2C4_RS27710	COG2197	response regulator
MLA2C4_RS27715	COG4585	Histidine kinase
MLA2C4_RS27720	COG0842	Transport permease protein
MLA2C4_RS27725	COG1131	(ABC) transporter
MLA2C4_RS27730	COG0024	Methionine aminopeptidase
MLA2C4_RS27735	COG2234	aminopeptidase activity
MLA2C4_RS27765	COG1595	DNA-templated transcription, initiation
MLA2C4_RS27780	COG1619	proteins homologs of microcin C7 resistance protein MccF
MLA2C4_RS27805	COG2814	Major facilitator Superfamily
MLA2C4_RS27810	COG0789	Transcriptional regulator
MLA2C4_RS27815	COG0584	glycerophosphoryl diester phosphodiesterase
MLA2C4_RS27820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MLA2C4_RS27830	COG1994	Peptidase M50
MLA2C4_RS27840	COG1078	dGTPase activity
MLA2C4_RS27845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MLA2C4_RS27850	COG1120	ATPase activity
MLA2C4_RS27855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS27860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MLA2C4_RS27865	COG4844	belongs to the
MLA2C4_RS27880	COG0640	Transcriptional regulator
MLA2C4_RS27885	COG0346	lactoylglutathione lyase activity
MLA2C4_RS27890	COG0798	PFAM Bile acid sodium symporter
MLA2C4_RS27915	COG0280	phosphate acetyltransferase
MLA2C4_RS27930	COG3773	Cell wall hydrolase
MLA2C4_RS27940	COG2363	Small membrane protein
MLA2C4_RS27950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MLA2C4_RS27955	COG2233	PERMEase
MLA2C4_RS27960	COG0561	phosphatase activity
MLA2C4_RS27965	COG2814	Major facilitator Superfamily
MLA2C4_RS27975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MLA2C4_RS27980	COG1131	(ABC) transporter
MLA2C4_RS27985	COG2755	lipolytic protein G-D-S-L family
MLA2C4_RS27990	COG1609	Transcriptional regulator
MLA2C4_RS28000	COG0460	homoserine dehydrogenase
MLA2C4_RS28010	COG2873	o-acetylhomoserine
MLA2C4_RS28020	COG1011	Hydrolase
MLA2C4_RS28025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MLA2C4_RS28035	COG2197	response regulator
MLA2C4_RS28040	COG2203	Gaf domain
MLA2C4_RS28040	COG4585	Histidine kinase
MLA2C4_RS28045	COG0351	phosphomethylpyrimidine kinase
MLA2C4_RS28060	COG2879	small protein
MLA2C4_RS28065	COG1966	Carbon starvation protein
MLA2C4_RS28070	COG3279	Response regulator of the LytR AlgR family
MLA2C4_RS28075	COG0477	Major facilitator Superfamily
MLA2C4_RS28100	COG0840	transmembrane signaling receptor activity
MLA2C4_RS28110	COG1607	acyl-coa hydrolase
MLA2C4_RS28125	COG0488	(ABC) transporter
MLA2C4_RS28145	COG0463	Glycosyl transferase, family 2
MLA2C4_RS28150	COG1309	transcriptional regulator
MLA2C4_RS28155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MLA2C4_RS28160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLA2C4_RS28160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MLA2C4_RS28165	COG0628	permease
MLA2C4_RS28175	COG1380	Effector of murein hydrolase LrgA
MLA2C4_RS28180	COG3279	Response regulator of the LytR AlgR family
MLA2C4_RS28185	COG3275	phosphorelay sensor kinase activity
MLA2C4_RS28190	COG2814	Major facilitator Superfamily
MLA2C4_RS28195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MLA2C4_RS28200	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MLA2C4_RS28210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MLA2C4_RS28260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MLA2C4_RS28265	COG1272	protein, Hemolysin III
MLA2C4_RS28295	COG1164	Oligoendopeptidase f
MLA2C4_RS28325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MLA2C4_RS28330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MLA2C4_RS28335	COG4853	Protein conserved in bacteria
MLA2C4_RS28340	COG4863	YycH protein
MLA2C4_RS28345	COG5002	protein histidine kinase activity
MLA2C4_RS28350	COG0745	RESPONSE REGULATOR receiver
MLA2C4_RS28380	COG0305	Participates in initiation and elongation during chromosome replication
MLA2C4_RS28390	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MLA2C4_RS28395	COG4241	membrane
MLA2C4_RS28405	COG0629	single-stranded DNA binding
MLA2C4_RS28415	COG0012	GTP binding
MLA2C4_RS28420	COG4481	Protein conserved in bacteria
MLA2C4_RS28425	COG0668	transmembrane transport
MLA2C4_RS28435	COG1475	DNA binding
MLA2C4_RS28440	COG1192	Involved in chromosome partitioning
MLA2C4_RS28465	COG1847	R3H domain protein
MLA2C4_RS28470	COG0706	membrane insertase activity
MLA2C4_RS28480	COG0230	Belongs to the bacterial ribosomal protein bL34 family