locus-tag	class	description
EXW58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW58_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW58_RS00015	COG2501	S4 domain
EXW58_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW58_RS00025	COG0187	DNA topoisomerase II activity
EXW58_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW58_RS00065	COG0516	GMP reductase activity
EXW58_RS00065	COG0517	IMP dehydrogenase activity
EXW58_RS00070	COG1686	Belongs to the peptidase S11 family
EXW58_RS00100	COG1428	Deoxynucleoside kinase
EXW58_RS00105	COG1428	Deoxynucleoside kinase
EXW58_RS00110	COG1335	isochorismatase
EXW58_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW58_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW58_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW58_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW58_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW58_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW58_RS00190	COG0470	DNA polymerase III
EXW58_RS00195	COG1774	PSP1 C-terminal conserved region
EXW58_RS00200	COG4467	Involved in initiation control of chromosome replication
EXW58_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW58_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW58_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW58_RS00230	COG0084	hydrolase, TatD family'
EXW58_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW58_RS00250	COG4466	Protein conserved in bacteria
EXW58_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW58_RS00270	COG0251	oxidation-reduction process
EXW58_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW58_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW58_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW58_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW58_RS00310	COG2244	polysaccharide biosynthetic process
EXW58_RS00315	COG3956	TIGRFAM MazG family protein
EXW58_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW58_RS00340	COG1098	S1 RNA binding domain
EXW58_RS00355	COG2208	phosphoserine phosphatase activity
EXW58_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW58_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW58_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW58_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW58_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW58_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW58_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW58_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW58_RS00420	COG1396	sequence-specific DNA binding
EXW58_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW58_RS00515	COG3880	PFAM UvrB UvrC protein
EXW58_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW58_RS00525	COG0542	response to heat
EXW58_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW58_RS00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW58_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW58_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW58_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW58_RS00560	COG1045	serine acetyltransferase
EXW58_RS00565	COG0215	cysteine-tRNA ligase activity
EXW58_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW58_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW58_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW58_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW58_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW58_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW58_RS00610	COG0081	regulation of translation
EXW58_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW58_RS00620	COG0222	ribosome binding
EXW58_RS00625	COG2813	Specifically methylates the guanine in position
EXW58_RS00630	COG0085	RNA polymerase activity
EXW58_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW58_RS00640	COG1358	cellular component organization or biogenesis
EXW58_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW58_RS00650	COG0049	tRNA binding
EXW58_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW58_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW58_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW58_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW58_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EXW58_RS00680	COG0089	rRNA binding
EXW58_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW58_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW58_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW58_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW58_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW58_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW58_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW58_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW58_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW58_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW58_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW58_RS00760	COG1841	ribosomal large subunit assembly
EXW58_RS00765	COG0200	Binds to the 23S rRNA
EXW58_RS00770	COG0201	protein transport
EXW58_RS00775	COG0563	adenylate kinase activity
EXW58_RS00780	COG0024	Methionine aminopeptidase
EXW58_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW58_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW58_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW58_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW58_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW58_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW58_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS00855	COG0489	protein tyrosine kinase activity
EXW58_RS00865	COG2194	sulfuric ester hydrolase activity
EXW58_RS00870	COG0726	polysaccharide deacetylase
EXW58_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW58_RS00955	COG4856	YbbR-like protein
EXW58_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS01010	COG2011	ABC-type metal ion transport system permease component
EXW58_RS01020	COG1464	Belongs to the NlpA lipoprotein family
EXW58_RS01025	COG0604	alcohol dehydrogenase
EXW58_RS01035	COG0277	FAD linked oxidase domain protein
EXW58_RS01040	COG2271	Major facilitator Superfamily
EXW58_RS01050	COG2814	Major facilitator Superfamily
EXW58_RS01070	COG0601	transmembrane transport
EXW58_RS01075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_RS01080	COG0444	Belongs to the ABC transporter superfamily
EXW58_RS01085	COG4608	Belongs to the ABC transporter superfamily
EXW58_RS01090	COG4166	transmembrane transport
EXW58_RS01105	COG2207	Transcriptional regulator
EXW58_RS01120	COG4166	transmembrane transport
EXW58_RS01125	COG4166	transmembrane transport
EXW58_RS01130	COG0656	L-ascorbic acid biosynthetic process
EXW58_RS01135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_RS01145	COG4149	molybdate abc transporter
EXW58_RS01150	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW58_RS01155	COG1910	domain protein
EXW58_RS01170	COG0697	spore germination
EXW58_RS01185	COG0204	Acyl-transferase
EXW58_RS01195	COG1609	Transcriptional regulator
EXW58_RS01205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS01225	COG5298	Protein conserved in bacteria
EXW58_RS01250	COG0488	(ABC) transporter
EXW58_RS01260	COG0747	negative chemotaxis
EXW58_RS01270	COG0601	transmembrane transport
EXW58_RS01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_RS01280	COG0444	Belongs to the ABC transporter superfamily
EXW58_RS01285	COG4608	Belongs to the ABC transporter superfamily
EXW58_RS01290	COG0561	phosphatase activity
EXW58_RS01315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW58_RS01320	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_RS01330	COG0531	amino acid
EXW58_RS01335	COG2814	Major facilitator Superfamily
EXW58_RS01345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW58_RS01355	COG4294	response to UV
EXW58_RS01360	COG0705	Rhomboid family
EXW58_RS01365	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW58_RS01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW58_RS01375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW58_RS01380	COG0864	Transcriptional regulator
EXW58_RS01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW58_RS01390	COG2183	response to ionizing radiation
EXW58_RS01490	COG0802	atpase or kinase
EXW58_RS01495	COG1214	PFAM Peptidase M22, glycoprotease
EXW58_RS01500	COG0456	acetyltransferase
EXW58_RS01510	COG0488	(ABC) transporter
EXW58_RS01515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW58_RS01525	COG1266	CAAX protease self-immunity
EXW58_RS01530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW58_RS01535	COG0459	protein refolding
EXW58_RS01540	COG0519	Catalyzes the synthesis of GMP from XMP
EXW58_RS01540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW58_RS01545	COG2252	PERMEase
EXW58_RS01555	COG5002	protein histidine kinase activity
EXW58_RS01575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW58_RS01615	COG4187	Peptidase family M20/M25/M40
EXW58_RS01635	COG2205	protein histidine kinase activity
EXW58_RS01640	COG0745	RESPONSE REGULATOR receiver
EXW58_RS01660	COG0697	spore germination
EXW58_RS01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW58_RS01690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW58_RS01695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW58_RS01700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW58_RS01705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW58_RS01715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW58_RS01720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW58_RS01725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW58_RS01730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW58_RS01735	COG0138	bifunctional purine biosynthesis protein purh
EXW58_RS01740	COG0151	Belongs to the GarS family
EXW58_RS01760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW58_RS01765	COG0210	DNA helicase
EXW58_RS01770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW58_RS01775	COG4851	CamS sex pheromone cAM373 precursor
EXW58_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS01790	COG1335	isochorismatase
EXW58_RS01800	COG2011	ABC-type metal ion transport system permease component
EXW58_RS01805	COG1464	Belongs to the NlpA lipoprotein family
EXW58_RS01815	COG0003	Pfam Anion-transporting ATPase
EXW58_RS01820	COG1846	Transcriptional regulator
EXW58_RS01825	COG4682	membrane
EXW58_RS01835	COG0154	amidase activity
EXW58_RS01840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW58_RS01845	COG1597	lipid kinase activity
EXW58_RS01855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS01870	COG2076	Multidrug Resistance protein
EXW58_RS01880	COG2309	aminopeptidase activity
EXW58_RS01895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS01905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW58_RS01910	COG5002	protein histidine kinase activity
EXW58_RS01920	COG4807	Protein conserved in bacteria
EXW58_RS01945	COG1757	Na H antiporter
EXW58_RS01950	COG1473	amidohydrolase
EXW58_RS01970	COG0450	alkyl hydroperoxide reductase
EXW58_RS01980	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW58_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS02005	COG0492	ferredoxin-NADP+ reductase activity
EXW58_RS02015	COG0166	Belongs to the GPI family
EXW58_RS02040	COG5002	protein histidine kinase activity
EXW58_RS02055	COG3541	Predicted nucleotidyltransferase
EXW58_RS02060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_RS02060	COG0723	plastoquinol--plastocyanin reductase activity
EXW58_RS02070	COG0765	amino acid transport
EXW58_RS02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS02080	COG1126	abc transporter atp-binding protein
EXW58_RS02085	COG0840	transmembrane signaling receptor activity
EXW58_RS02090	COG0277	FAD linked oxidase domain protein
EXW58_RS02095	COG0366	Alpha amylase catalytic
EXW58_RS02100	COG2190	(PTS) system
EXW58_RS02100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS02100	COG1263	PTS System
EXW58_RS02125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW58_RS02130	COG0352	thiamine-phosphate diphosphorylase activity
EXW58_RS02135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW58_RS02155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_RS02165	COG1116	anion transmembrane transporter activity
EXW58_RS02170	COG0488	(ABC) transporter
EXW58_RS02195	COG2270	Major facilitator Superfamily
EXW58_RS02225	COG2310	stress, protein
EXW58_RS02230	COG2310	stress, protein
EXW58_RS02235	COG2310	stress, protein
EXW58_RS02240	COG0861	Integral membrane protein TerC family
EXW58_RS02250	COG3853	Toxic anion resistance protein (TelA)
EXW58_RS02260	COG4840	Belongs to the UPF0435 family
EXW58_RS02265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW58_RS02275	COG1295	ribonuclease BN
EXW58_RS02280	COG2217	Heavy metal translocating P-type atpase
EXW58_RS02285	COG0697	spore germination
EXW58_RS02310	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS02325	COG3871	stress protein (general stress protein 26)
EXW58_RS02330	COG0387	Pfam Sodium calcium exchanger
EXW58_RS02340	COG0535	radical SAM domain protein
EXW58_RS02360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW58_RS02365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXW58_RS02385	COG3829	transcription factor binding
EXW58_RS02395	COG0833	amino acid
EXW58_RS02400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_RS02425	COG1263	PTS System
EXW58_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS02430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_RS02450	COG0463	Glycosyl transferase, family 2
EXW58_RS02460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_RS02460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW58_RS02480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW58_RS02485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW58_RS02500	COG1228	amidohydrolase
EXW58_RS02505	COG1090	epimerase
EXW58_RS02510	COG2137	regulation of response to DNA damage stimulus
EXW58_RS02535	COG1988	membrane-bound metal-dependent
EXW58_RS02540	COG1194	a g-specific adenine glycosylase
EXW58_RS02560	COG3557	Belongs to the UPF0374 family
EXW58_RS02565	COG1132	(ABC) transporter
EXW58_RS02570	COG4129	membrane
EXW58_RS02575	COG0067	glutamate synthase
EXW58_RS02575	COG0069	glutamate synthase activity
EXW58_RS02575	COG0070	glutamate synthase
EXW58_RS02580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW58_RS02585	COG4555	ABC transporter
EXW58_RS02605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW58_RS02610	COG0735	belongs to the Fur family
EXW58_RS02725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW58_RS02730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW58_RS02750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW58_RS02760	COG2766	serine protein kinase
EXW58_RS02765	COG2718	Belongs to the UPF0229 family
EXW58_RS02780	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW58_RS02785	COG2268	Band 7 protein
EXW58_RS02790	COG3290	protein histidine kinase activity
EXW58_RS02795	COG4565	transcriptional regulatory protein
EXW58_RS02805	COG2851	Citrate transporter
EXW58_RS02825	COG0745	RESPONSE REGULATOR receiver
EXW58_RS02830	COG5002	protein histidine kinase activity
EXW58_RS02840	COG4990	cell redox homeostasis
EXW58_RS02850	COG3290	protein histidine kinase activity
EXW58_RS02855	COG4565	transcriptional regulatory protein
EXW58_RS02860	COG3493	citrate carrier protein
EXW58_RS02865	COG0281	malic enzyme
EXW58_RS02875	COG0697	spore germination
EXW58_RS02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS02890	COG5002	protein histidine kinase activity
EXW58_RS02895	COG0745	RESPONSE REGULATOR receiver
EXW58_RS02900	COG0456	acetyltransferase
EXW58_RS02905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW58_RS02910	COG3383	formate dehydrogenase (NAD+) activity
EXW58_RS02915	COG2427	Protein of unknown function (DUF1641)
EXW58_RS02930	COG0531	amino acid
EXW58_RS02940	COG0640	Transcriptional regulator
EXW58_RS02945	COG2217	Heavy metal translocating P-type atpase
EXW58_RS02950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW58_RS02965	COG3227	Zinc metalloprotease (Elastase)
EXW58_RS02985	COG2720	vancomycin resistance protein
EXW58_RS02990	COG1316	TRANSCRIPTIONal
EXW58_RS02995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS03000	COG0346	lactoylglutathione lyase activity
EXW58_RS03005	COG1253	flavin adenine dinucleotide binding
EXW58_RS03010	COG1027	Aspartate ammonia-lyase
EXW58_RS03015	COG1620	l-lactate permease
EXW58_RS03020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS03035	COG3104	oligopeptide transport
EXW58_RS03040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS03045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS03050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS03065	COG0156	8-amino-7-oxononanoate synthase activity
EXW58_RS03070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_RS03080	COG2801	Transposase and inactivated derivatives
EXW58_RS03090	COG4548	von Willebrand factor, type A
EXW58_RS03095	COG0714	Associated with various cellular activities
EXW58_RS03120	COG0531	amino acid
EXW58_RS03125	COG2188	Transcriptional regulator
EXW58_RS03130	COG1263	PTS System
EXW58_RS03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS03135	COG0366	Alpha amylase catalytic
EXW58_RS03155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW58_RS03160	COG1115	amino acid carrier protein
EXW58_RS03165	COG1126	abc transporter atp-binding protein
EXW58_RS03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS03175	COG0765	amino acid transport
EXW58_RS03180	COG0765	amino acid transport
EXW58_RS03185	COG0833	amino acid
EXW58_RS03200	COG2378	regulation of single-species biofilm formation
EXW58_RS03205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW58_RS03210	COG5002	protein histidine kinase activity
EXW58_RS03225	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_RS03250	COG0601	transmembrane transport
EXW58_RS03255	COG4608	Belongs to the ABC transporter superfamily
EXW58_RS03265	COG2271	Major facilitator Superfamily
EXW58_RS03270	COG1846	Transcriptional regulator
EXW58_RS03275	COG0477	Major facilitator Superfamily
EXW58_RS03280	COG1609	Transcriptional regulator
EXW58_RS03285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW58_RS03290	COG1869	D-ribose catabolic process
EXW58_RS03300	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW58_RS03305	COG1879	ABC-type sugar transport system periplasmic component
EXW58_RS03335	COG1063	alcohol dehydrogenase
EXW58_RS03380	COG0840	transmembrane signaling receptor activity
EXW58_RS03385	COG1388	LysM domain
EXW58_RS03385	COG3584	3D domain protein
EXW58_RS03390	COG1476	TRANSCRIPTIONal
EXW58_RS03410	COG3104	oligopeptide transport
EXW58_RS03415	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS03430	COG1113	amino acid transport
EXW58_RS03435	COG2252	PERMEase
EXW58_RS03450	COG2153	protein acetylation
EXW58_RS03460	COG0569	domain protein
EXW58_RS03460	COG0475	glutathione-regulated potassium exporter activity
EXW58_RS03470	COG1845	cytochrome c oxidase, subunit III
EXW58_RS03475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW58_RS03480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXW58_RS03485	COG0833	amino acid
EXW58_RS03490	COG4990	cell redox homeostasis
EXW58_RS03505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_RS03510	COG0697	spore germination
EXW58_RS03515	COG0531	amino acid
EXW58_RS03530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW58_RS03535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW58_RS03545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW58_RS03550	COG0573	inorganic phosphate transmembrane transporter activity
EXW58_RS03555	COG0581	inorganic phosphate transmembrane transporter activity
EXW58_RS03565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW58_RS03610	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_RS03690	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW58_RS03705	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS03705	COG4991	sh3 domain protein
EXW58_RS03705	COG3103	Sh3 type 3 domain protein
EXW58_RS03710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW58_RS03715	COG1116	anion transmembrane transporter activity
EXW58_RS03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_RS03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW58_RS03730	COG0352	thiamine-phosphate diphosphorylase activity
EXW58_RS03735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_RS03740	COG2104	thiamine diphosphate biosynthetic process
EXW58_RS03745	COG2022	thiamine diphosphate biosynthetic process
EXW58_RS03750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_RS03755	COG0351	phosphomethylpyrimidine kinase
EXW58_RS03785	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW58_RS03790	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW58_RS03795	COG2205	protein histidine kinase activity
EXW58_RS03820	COG1136	(ABC) transporter
EXW58_RS03830	COG2252	PERMEase
EXW58_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS03895	COG0778	Nitroreductase
EXW58_RS03900	COG2719	SpoVR family
EXW58_RS03925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_RS03935	COG1937	Protein conserved in bacteria
EXW58_RS03940	COG0425	Belongs to the sulfur carrier protein TusA family
EXW58_RS03940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_RS03945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_RS03945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS03950	COG0425	Belongs to the sulfur carrier protein TusA family
EXW58_RS03955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_RS03960	COG2210	Belongs to the sulfur carrier protein TusA family
EXW58_RS03965	COG0730	response to heat
EXW58_RS03975	COG1316	TRANSCRIPTIONal
EXW58_RS03980	COG0604	alcohol dehydrogenase
EXW58_RS03985	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW58_RS03995	COG2814	Major facilitator Superfamily
EXW58_RS04005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_RS04005	COG3711	transcriptional antiterminator
EXW58_RS04010	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_RS04015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_RS04045	COG3584	3D domain protein
EXW58_RS04045	COG1388	LysM domain
EXW58_RS04050	COG0577	efflux transmembrane transporter activity
EXW58_RS04055	COG1136	(ABC) transporter
EXW58_RS04070	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS04075	COG3546	catalase activity
EXW58_RS04105	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS04135	COG0531	amino acid
EXW58_RS04140	COG0475	glutathione-regulated potassium exporter activity
EXW58_RS04150	COG1737	Transcriptional regulator
EXW58_RS04160	COG1263	PTS System
EXW58_RS04160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS04170	COG2259	Doxx family
EXW58_RS04195	COG1522	sequence-specific DNA binding
EXW58_RS04220	COG2076	Multidrug Resistance protein
EXW58_RS04225	COG1309	transcriptional regulator
EXW58_RS04230	COG2814	Major facilitator Superfamily
EXW58_RS04235	COG1733	regulation of RNA biosynthetic process
EXW58_RS04270	COG4473	ABC transporter
EXW58_RS04280	COG0531	amino acid
EXW58_RS04285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXW58_RS04290	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS04295	COG1132	(ABC) transporter
EXW58_RS04300	COG1132	(ABC) transporter
EXW58_RS04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS04310	COG0765	amino acid transport
EXW58_RS04315	COG1126	abc transporter atp-binding protein
EXW58_RS04330	COG0189	ligase activity
EXW58_RS04340	COG4399	Belongs to the UPF0754 family
EXW58_RS04345	COG3679	Belongs to the UPF0342 family
EXW58_RS04350	COG0463	Glycosyl transferase, family 2
EXW58_RS04355	COG1216	Glycosyl transferase, family 2
EXW58_RS04360	COG2094	Belongs to the DNA glycosylase MPG family
EXW58_RS04365	COG0561	phosphatase activity
EXW58_RS04375	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS04375	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_RS04380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW58_RS04385	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS04400	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS04410	COG4978	Transcriptional regulator
EXW58_RS04410	COG0789	Transcriptional regulator
EXW58_RS04420	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_RS04425	COG2244	polysaccharide biosynthetic process
EXW58_RS04445	COG1024	Enoyl-CoA hydratase
EXW58_RS04460	COG1363	Peptidase, m42
EXW58_RS04475	COG2801	Transposase and inactivated derivatives
EXW58_RS04490	COG2318	DinB family
EXW58_RS04500	COG1113	amino acid transport
EXW58_RS04505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS04525	COG0579	oxidoreductase
EXW58_RS04530	COG2226	methyltransferase
EXW58_RS04535	COG3290	protein histidine kinase activity
EXW58_RS04535	COG3829	transcription factor binding
EXW58_RS04545	COG1301	dicarboxylic acid transport
EXW58_RS04595	COG0477	Major facilitator Superfamily
EXW58_RS04600	COG3290	protein histidine kinase activity
EXW58_RS04605	COG4565	transcriptional regulatory protein
EXW58_RS04610	COG3181	Tripartite tricarboxylate transporter family receptor
EXW58_RS04640	COG0433	COG0433 Predicted ATPase
EXW58_RS04665	COG1074	ATP-dependent DNA helicase activity
EXW58_RS04675	COG1104	cysteine desulfurase activity
EXW58_RS04710	COG0305	Participates in initiation and elongation during chromosome replication
EXW58_RS04740	COG1842	Phage shock protein A
EXW58_RS04750	COG0477	Major facilitator Superfamily
EXW58_RS04795	COG2814	Major facilitator Superfamily
EXW58_RS04800	COG0640	Transcriptional regulator
EXW58_RS04830	COG2376	Dihydroxyacetone kinase
EXW58_RS04840	COG2376	Dihydroxyacetone kinase
EXW58_RS04860	COG2720	vancomycin resistance protein
EXW58_RS04865	COG1335	isochorismatase
EXW58_RS04880	COG2373	Large extracellular alpha-helical protein
EXW58_RS04920	COG0076	glutamate decarboxylase activity
EXW58_RS04940	COG2807	transmembrane transport
EXW58_RS04945	COG2186	Transcriptional regulator
EXW58_RS04960	COG4585	Histidine kinase
EXW58_RS04965	COG2197	response regulator
EXW58_RS04990	COG0420	3'-5' exonuclease activity
EXW58_RS04995	COG4717	serine-type aminopeptidase activity
EXW58_RS05000	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW58_RS05010	COG1733	regulation of RNA biosynthetic process
EXW58_RS05015	COG0778	Nitroreductase
EXW58_RS05040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_RS05050	COG0346	lactoylglutathione lyase activity
EXW58_RS05055	COG0346	lactoylglutathione lyase activity
EXW58_RS05060	COG2267	carboxylic ester hydrolase activity
EXW58_RS05070	COG2140	Oxalate decarboxylase
EXW58_RS05075	COG3620	sequence-specific DNA binding
EXW58_RS05080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW58_RS05085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW58_RS05090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW58_RS05095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW58_RS05100	COG1595	DNA-templated transcription, initiation
EXW58_RS05115	COG1309	transcriptional regulator
EXW58_RS05120	COG2814	Major facilitator Superfamily
EXW58_RS05125	COG3973	AAA domain
EXW58_RS05155	COG0537	adenosine 5'-monophosphoramidase activity
EXW58_RS05160	COG1131	(ABC) transporter
EXW58_RS05165	COG4473	ABC transporter
EXW58_RS05195	COG0247	lactate metabolic process
EXW58_RS05200	COG1139	Iron-sulfur cluster binding protein
EXW58_RS05205	COG1556	Lactate utilization protein
EXW58_RS05240	COG1309	transcriptional regulator
EXW58_RS05250	COG3402	PFAM membrane-flanked domain
EXW58_RS05255	COG3428	Bacterial PH domain
EXW58_RS05280	COG3402	PFAM membrane-flanked domain
EXW58_RS05285	COG3428	Bacterial PH domain
EXW58_RS05290	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_RS05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_RS05305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW58_RS05310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW58_RS05330	COG1309	transcriptional regulator
EXW58_RS05335	COG1511	domain protein
EXW58_RS05340	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS05340	COG1216	Glycosyl transferase, family 2
EXW58_RS05365	COG2378	regulation of single-species biofilm formation
EXW58_RS05370	COG1609	Transcriptional regulator
EXW58_RS05380	COG1234	tRNA 3'-trailer cleavage
EXW58_RS05385	COG0095	Lipoate-protein ligase
EXW58_RS05395	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS05405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW58_RS05410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW58_RS05415	COG4208	sulfate ABC transporter
EXW58_RS05430	COG1408	metallophosphoesterase
EXW58_RS05435	COG1078	dGTPase activity
EXW58_RS05445	COG2801	Transposase and inactivated derivatives
EXW58_RS05460	COG1595	DNA-templated transcription, initiation
EXW58_RS05465	COG2207	Transcriptional regulator
EXW58_RS05465	COG3708	Transcriptional regulator
EXW58_RS05470	COG2205	protein histidine kinase activity
EXW58_RS05475	COG0745	RESPONSE REGULATOR receiver
EXW58_RS05490	COG0501	Belongs to the peptidase M48B family
EXW58_RS05495	COG0697	spore germination
EXW58_RS05510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW58_RS05515	COG2224	Isocitrate lyase
EXW58_RS05525	COG1278	Cold shock
EXW58_RS05530	COG1216	Glycosyl transferase, family 2
EXW58_RS05545	COG4903	ComK protein
EXW58_RS05555	COG0398	Pfam SNARE associated Golgi protein
EXW58_RS05565	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW58_RS05570	COG1074	ATP-dependent DNA helicase activity
EXW58_RS05620	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_RS05645	COG0367	asparagine synthase
EXW58_RS05655	COG0753	catalase activity
EXW58_RS05660	COG0004	ammonium transporteR
EXW58_RS05675	COG1666	GTP binding
EXW58_RS05680	COG2996	Protein conserved in bacteria
EXW58_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW58_RS05695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS05710	COG0561	phosphatase activity
EXW58_RS05730	COG2267	carboxylic ester hydrolase activity
EXW58_RS05745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_RS05750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW58_RS05755	COG5504	Zn-dependent protease
EXW58_RS05765	COG0180	Tryptophanyl-tRNA synthetase
EXW58_RS05775	COG4166	transmembrane transport
EXW58_RS05780	COG0601	transmembrane transport
EXW58_RS05785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_RS05790	COG0444	Belongs to the ABC transporter superfamily
EXW58_RS05795	COG4608	Belongs to the ABC transporter superfamily
EXW58_RS05800	COG0534	Mate efflux family protein
EXW58_RS05805	COG4166	transmembrane transport
EXW58_RS05820	COG0861	Integral membrane protein TerC family
EXW58_RS05825	COG4862	establishment of competence for transformation
EXW58_RS05830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_RS05840	COG1164	Oligoendopeptidase f
EXW58_RS05850	COG2346	COG2346, Truncated hemoglobins
EXW58_RS05855	COG4116	CYTH
EXW58_RS05865	COG2357	RelA SpoT domain protein
EXW58_RS05875	COG0564	pseudouridine synthase activity
EXW58_RS05885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW58_RS05890	COG0772	Belongs to the SEDS family
EXW58_RS05900	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW58_RS05915	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW58_RS05960	COG2153	protein acetylation
EXW58_RS05965	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW58_RS05970	COG2382	esterase
EXW58_RS05995	COG5492	domain, Protein
EXW58_RS06000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_RS06010	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW58_RS06010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW58_RS06015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW58_RS06020	COG0134	indole-3-glycerol-phosphate synthase activity
EXW58_RS06025	COG0135	phosphoribosylanthranilate isomerase activity
EXW58_RS06035	COG0159	tryptophan synthase activity
EXW58_RS06045	COG1620	l-lactate permease
EXW58_RS06050	COG5634	Uncharacterized conserved protein (DUF2278)
EXW58_RS06085	COG2226	methyltransferase
EXW58_RS06105	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_RS06110	COG0567	Dehydrogenase, E1 component
EXW58_RS06115	COG1476	TRANSCRIPTIONal
EXW58_RS06160	COG1686	Belongs to the peptidase S11 family
EXW58_RS06165	COG0681	Belongs to the peptidase S26 family
EXW58_RS06200	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS06210	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW58_RS06215	COG1177	transmembrane transport
EXW58_RS06220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW58_RS06230	COG2409	Drug exporters of the RND superfamily
EXW58_RS06240	COG0564	pseudouridine synthase activity
EXW58_RS06250	COG2340	Cysteine-rich secretory protein family
EXW58_RS06255	COG0247	lactate metabolic process
EXW58_RS06260	COG0277	FAD linked oxidase domain protein
EXW58_RS06265	COG3835	regulator
EXW58_RS06275	COG0745	RESPONSE REGULATOR receiver
EXW58_RS06280	COG3850	Histidine kinase
EXW58_RS06280	COG5002	protein histidine kinase activity
EXW58_RS06285	COG2186	Transcriptional regulator
EXW58_RS06300	COG1556	Lactate utilization protein
EXW58_RS06305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW58_RS06325	COG2116	formate transmembrane transporter activity
EXW58_RS06330	COG0861	Integral membrane protein TerC family
EXW58_RS06335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_RS06345	COG2030	dehydratase
EXW58_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS06370	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW58_RS06380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_RS06395	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW58_RS06400	COG3842	ATPase activity
EXW58_RS06410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW58_RS06415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW58_RS06425	COG1349	DNA-binding transcription factor activity
EXW58_RS06435	COG0235	Class ii aldolase
EXW58_RS06445	COG2861	carbohydrate metabolic process
EXW58_RS06455	COG3852	Histidine kinase
EXW58_RS06460	COG1846	Transcriptional regulator
EXW58_RS06470	COG2318	DinB family
EXW58_RS06475	COG5002	protein histidine kinase activity
EXW58_RS06485	COG0720	synthase
EXW58_RS06495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW58_RS06500	COG4873	Protein conserved in bacteria
EXW58_RS06515	COG0456	acetyltransferase
EXW58_RS06530	COG1780	Probably involved in ribonucleotide reductase function
EXW58_RS06545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW58_RS06550	COG0531	amino acid
EXW58_RS06565	COG2204	response regulator
EXW58_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS06585	COG1725	Transcriptional regulator
EXW58_RS06590	COG1131	(ABC) transporter
EXW58_RS06600	COG1131	(ABC) transporter
EXW58_RS06605	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_RS06610	COG1266	CAAX protease self-immunity
EXW58_RS06620	COG1522	sequence-specific DNA binding
EXW58_RS06630	COG1335	isochorismatase
EXW58_RS06640	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW58_RS06645	COG2070	2-Nitropropane dioxygenase
EXW58_RS06650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW58_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_RS06660	COG1696	Membrane protein involved in D-alanine export
EXW58_RS06685	COG0716	FMN binding
EXW58_RS06700	COG3173	Aminoglycoside phosphotransferase
EXW58_RS06720	COG0534	Mate efflux family protein
EXW58_RS06740	COG1846	Transcriptional regulator
EXW58_RS06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_RS06765	COG3874	Sporulation protein YtfJ
EXW58_RS06785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS06790	COG0028	Belongs to the TPP enzyme family
EXW58_RS06795	COG0440	acetolactate synthase activity
EXW58_RS06805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_RS06815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW58_RS06825	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW58_RS06830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW58_RS06840	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW58_RS06845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW58_RS06850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW58_RS06855	COG0107	imidazoleglycerol-phosphate synthase activity
EXW58_RS06865	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW58_RS06870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW58_RS06885	COG1183	phosphatidylcholine synthase activity
EXW58_RS06890	COG1368	sulfuric ester hydrolase activity
EXW58_RS06900	COG0019	diaminopimelate decarboxylase activity
EXW58_RS06915	COG2046	Belongs to the sulfate adenylyltransferase family
EXW58_RS06920	COG0529	Catalyzes the synthesis of activated sulfate
EXW58_RS06925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW58_RS06945	COG1648	precorrin-2 dehydrogenase activity
EXW58_RS06950	COG0733	neurotransmitter:sodium symporter activity
EXW58_RS06975	COG1757	Na H antiporter
EXW58_RS06980	COG3344	reverse transcriptase
EXW58_RS06995	COG4758	membrane
EXW58_RS07000	COG4585	Histidine kinase
EXW58_RS07005	COG2197	response regulator
EXW58_RS07015	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS07065	COG0730	response to heat
EXW58_RS07070	COG0306	phosphate transporter
EXW58_RS07075	COG1392	Phosphate transport regulator
EXW58_RS07080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_RS07095	COG3852	Histidine kinase
EXW58_RS07100	COG1801	Protein of unknown function DUF72
EXW58_RS07110	COG0582	viral genome integration into host DNA
EXW58_RS07115	COG5002	protein histidine kinase activity
EXW58_RS07130	COG0392	lysyltransferase activity
EXW58_RS07130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW58_RS07145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW58_RS07150	COG1686	Belongs to the peptidase S11 family
EXW58_RS07155	COG2715	membrane protein required for spore maturation
EXW58_RS07160	COG0700	Nucleoside recognition
EXW58_RS07165	COG1187	pseudouridine synthase activity
EXW58_RS07175	COG1333	cytochrome c biogenesis protein
EXW58_RS07180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW58_RS07185	COG0745	RESPONSE REGULATOR receiver
EXW58_RS07190	COG5002	protein histidine kinase activity
EXW58_RS07195	COG2096	Adenosyltransferase
EXW58_RS07200	COG4942	peptidase
EXW58_RS07210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW58_RS07215	COG1141	Ferredoxin
EXW58_RS07220	COG4955	Helix-turn-helix domain
EXW58_RS07225	COG0514	ATP-dependent DNA helicase (RecQ)
EXW58_RS07230	COG1266	CAAX protease self-immunity
EXW58_RS07240	COG1408	metallophosphoesterase
EXW58_RS07255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW58_RS07270	COG0492	ferredoxin-NADP+ reductase activity
EXW58_RS07275	COG0252	asparaginase activity
EXW58_RS07285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW58_RS07295	COG1304	FMN binding
EXW58_RS07325	COG1160	GTP binding
EXW58_RS07350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_RS07365	COG0142	geranyltranstransferase activity
EXW58_RS07370	COG2226	methyltransferase
EXW58_RS07375	COG0142	geranyltranstransferase activity
EXW58_RS07390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW58_RS07400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW58_RS07405	COG0457	Tetratricopeptide repeat
EXW58_RS07410	COG5582	Belongs to the UPF0302 family
EXW58_RS07425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW58_RS07430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW58_RS07430	COG2010	Cytochrome c
EXW58_RS07435	COG3344	reverse transcriptase
EXW58_RS07440	COG4347	Protein of unknown function (DUF1405)
EXW58_RS07455	COG2738	Putative neutral zinc metallopeptidase
EXW58_RS07465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS07475	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW58_RS07480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW58_RS07485	COG1803	Methylglyoxal synthase
EXW58_RS07490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_RS07495	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS07500	COG0617	tRNA 3'-terminal CCA addition
EXW58_RS07510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW58_RS07515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW58_RS07525	COG1199	ATP-dependent helicase activity
EXW58_RS07525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW58_RS07545	COG3935	DnaD domain protein
EXW58_RS07550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW58_RS07560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_RS07560	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_RS07565	COG3331	DNA recombination
EXW58_RS07600	COG4474	Belongs to the UPF0398 family
EXW58_RS07605	COG3599	regulation of cell shape
EXW58_RS07615	COG0116	Belongs to the methyltransferase superfamily
EXW58_RS07625	COG1199	ATP-dependent helicase activity
EXW58_RS07630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW58_RS07640	COG0024	Methionine aminopeptidase
EXW58_RS07650	COG2233	PERMEase
EXW58_RS07655	COG2311	Membrane
EXW58_RS07665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_RS07675	COG0456	acetyltransferase
EXW58_RS07685	COG2897	thiosulfate sulfurtransferase activity
EXW58_RS07725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_RS07765	COG0328	RNA-DNA hybrid ribonuclease activity
EXW58_RS07800	COG3403	YqcI/YcgG family
EXW58_RS07805	COG1280	lysine exporter protein (LysE YggA)
EXW58_RS07820	COG3162	membrane
EXW58_RS07825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_RS07830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_RS07840	COG0475	glutathione-regulated potassium exporter activity
EXW58_RS07845	COG0789	Transcriptional regulator
EXW58_RS07845	COG4978	Transcriptional regulator
EXW58_RS07855	COG2323	membrane
EXW58_RS07860	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW58_RS07905	COG1923	regulation of RNA biosynthetic process
EXW58_RS07925	COG0861	Integral membrane protein TerC family
EXW58_RS07935	COG3383	formate dehydrogenase (NAD+) activity
EXW58_RS07940	COG2427	Protein of unknown function (DUF1641)
EXW58_RS07945	COG5609	conserved protein (DUF2294)
EXW58_RS07950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW58_RS07960	COG2116	formate transmembrane transporter activity
EXW58_RS07965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_RS07970	COG0303	'Molybdopterin
EXW58_RS07975	COG0314	molybdopterin synthase activity
EXW58_RS07990	COG0489	protein tyrosine kinase activity
EXW58_RS07995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW58_RS08000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW58_RS08010	COG1419	protein localization to endoplasmic reticulum
EXW58_RS08020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_RS08050	COG0412	Dienelactone hydrolase
EXW58_RS08055	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_RS08070	COG3764	Sortase (surface protein transpeptidase)
EXW58_RS08085	COG2801	Transposase and inactivated derivatives
EXW58_RS08115	COG0583	DNA-binding transcription factor activity
EXW58_RS08120	COG3842	ATPase activity
EXW58_RS08160	COG1686	Belongs to the peptidase S11 family
EXW58_RS08185	COG1846	Transcriptional regulator
EXW58_RS08195	COG0367	asparagine synthase
EXW58_RS08225	COG1757	Na H antiporter
EXW58_RS08235	COG0277	FAD linked oxidase domain protein
EXW58_RS08255	COG0534	Mate efflux family protein
EXW58_RS08260	COG3340	Belongs to the peptidase S51 family
EXW58_RS08280	COG0785	Cytochrome C biogenesis protein
EXW58_RS08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS08300	COG3048	D-serine ammonia-lyase activity
EXW58_RS08305	COG2733	membrane
EXW58_RS08340	COG1131	(ABC) transporter
EXW58_RS08360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_RS08365	COG0528	UMP kinase activity
EXW58_RS08375	COG1027	Aspartate ammonia-lyase
EXW58_RS08380	COG0281	malic enzyme
EXW58_RS08385	COG4191	Histidine kinase
EXW58_RS08390	COG0784	Response regulator, receiver
EXW58_RS08395	COG1846	Transcriptional regulator
EXW58_RS08405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_RS08420	COG2502	aspartate--ammonia ligase
EXW58_RS08455	COG2814	Major facilitator Superfamily
EXW58_RS08475	COG1595	DNA-templated transcription, initiation
EXW58_RS08490	COG1695	Transcriptional regulator
EXW58_RS08505	COG0477	Major facilitator Superfamily
EXW58_RS08510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_RS08520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW58_RS08525	COG2223	nitrite transmembrane transporter activity
EXW58_RS08530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_RS08545	COG2244	polysaccharide biosynthetic process
EXW58_RS08550	COG0733	neurotransmitter:sodium symporter activity
EXW58_RS08560	COG5566	PFAM Mor transcription activator
EXW58_RS08565	COG2323	membrane
EXW58_RS08580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_RS08595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW58_RS08620	COG2814	Major facilitator Superfamily
EXW58_RS08625	COG3384	dioxygenase
EXW58_RS08660	COG4166	transmembrane transport
EXW58_RS08670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS08680	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW58_RS08685	COG1054	Belongs to the UPF0176 family
EXW58_RS08695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW58_RS08700	COG0531	amino acid
EXW58_RS08720	COG1280	lysine exporter protein (LysE YggA)
EXW58_RS08735	COG2390	Transcriptional regulator
EXW58_RS08740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW58_RS08745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS08750	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW58_RS08765	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW58_RS08780	COG2267	carboxylic ester hydrolase activity
EXW58_RS08785	COG0583	DNA-binding transcription factor activity
EXW58_RS08800	COG0006	proline dipeptidase activity
EXW58_RS08805	COG2132	Multicopper oxidase
EXW58_RS08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW58_RS08835	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS08845	COG2372	response to copper ion
EXW58_RS08845	COG1276	copper resistance
EXW58_RS08850	COG4549	nuclear export factor GLE1
EXW58_RS08855	COG0697	spore germination
EXW58_RS08860	COG0583	DNA-binding transcription factor activity
EXW58_RS08870	COG1959	2 iron, 2 sulfur cluster binding
EXW58_RS08875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW58_RS08890	COG0628	permease
EXW58_RS08905	COG1231	oxidoreductase activity
EXW58_RS08910	COG0523	cobalamin synthesis protein
EXW58_RS08925	COG2030	dehydratase
EXW58_RS08930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_RS08945	COG0411	ABC transporter
EXW58_RS08965	COG0583	DNA-binding transcription factor activity
EXW58_RS08975	COG1942	4-Oxalocrotonate Tautomerase
EXW58_RS08990	COG0346	lactoylglutathione lyase activity
EXW58_RS09000	COG1271	oxidase subunit
EXW58_RS09005	COG1294	oxidase, subunit
EXW58_RS09010	COG4988	ABC transporter
EXW58_RS09015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW58_RS09045	COG1686	Belongs to the peptidase S11 family
EXW58_RS09055	COG0791	NLP P60 protein
EXW58_RS09055	COG1388	LysM domain
EXW58_RS09065	COG1132	(ABC) transporter
EXW58_RS09070	COG0745	RESPONSE REGULATOR receiver
EXW58_RS09075	COG5002	protein histidine kinase activity
EXW58_RS09080	COG0300	oxidoreductase activity
EXW58_RS09085	COG4122	O-methyltransferase activity
EXW58_RS09115	COG0460	homoserine dehydrogenase
EXW58_RS09125	COG0083	homoserine kinase activity
EXW58_RS09140	COG1316	TRANSCRIPTIONal
EXW58_RS09155	COG1285	pathogenesis
EXW58_RS09160	COG1247	-acetyltransferase
EXW58_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_RS09190	COG1082	Xylose isomerase domain protein TIM barrel
EXW58_RS09200	COG2814	Major facilitator Superfamily
EXW58_RS09205	COG1279	arginine transmembrane transporter activity
EXW58_RS09210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS09215	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW58_RS09250	COG0577	efflux transmembrane transporter activity
EXW58_RS09255	COG2002	toxin-antitoxin pair type II binding
EXW58_RS09260	COG1404	Belongs to the peptidase S8 family
EXW58_RS09295	COG0840	transmembrane signaling receptor activity
EXW58_RS09335	COG3949	Membrane
EXW58_RS09340	COG0783	Belongs to the Dps family
EXW58_RS09355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_RS09365	COG1231	oxidoreductase activity
EXW58_RS09370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS09375	COG4989	oxidoreductase activity
EXW58_RS09380	COG0523	cobalamin synthesis protein
EXW58_RS09385	COG0456	acetyltransferase
EXW58_RS09390	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW58_RS09400	COG0702	epimerase
EXW58_RS09445	COG3331	DNA recombination
EXW58_RS09465	COG1388	LysM domain
EXW58_RS09465	COG4641	Protein conserved in bacteria
EXW58_RS09555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW58_RS09565	COG4166	transmembrane transport
EXW58_RS09580	COG0406	alpha-ribazole phosphatase activity
EXW58_RS09590	COG5337	Spore coat protein CotH
EXW58_RS09595	COG1051	belongs to the nudix hydrolase family
EXW58_RS09600	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS09605	COG2244	polysaccharide biosynthetic process
EXW58_RS09615	COG0701	Predicted permease
EXW58_RS09620	COG3689	TIGRFAM TIGR03943 family protein
EXW58_RS09625	COG1607	acyl-coa hydrolase
EXW58_RS09635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_RS09650	COG0702	epimerase
EXW58_RS09655	COG2839	Protein conserved in bacteria
EXW58_RS09660	COG1253	flavin adenine dinucleotide binding
EXW58_RS09675	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW58_RS09695	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS09705	COG1876	peptidase activity
EXW58_RS09730	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS09735	COG2368	4-hydroxyphenylacetate
EXW58_RS09760	COG0251	oxidation-reduction process
EXW58_RS09770	COG3971	2-oxopent-4-enoate hydratase activity
EXW58_RS09790	COG1942	4-Oxalocrotonate Tautomerase
EXW58_RS09805	COG1846	Transcriptional regulator
EXW58_RS09810	COG2814	Major facilitator Superfamily
EXW58_RS09820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW58_RS09830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS09835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS09860	COG0456	acetyltransferase
EXW58_RS09900	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_RS09980	COG3874	Sporulation protein YtfJ
EXW58_RS10005	COG2226	methyltransferase
EXW58_RS10025	COG0346	lactoylglutathione lyase activity
EXW58_RS10035	COG0604	alcohol dehydrogenase
EXW58_RS10040	COG1595	DNA-templated transcription, initiation
EXW58_RS10055	COG2801	Transposase and inactivated derivatives
EXW58_RS10075	COG0426	domain, Protein
EXW58_RS10075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW58_RS10085	COG0386	Belongs to the glutathione peroxidase family
EXW58_RS10090	COG1305	Transglutaminase-like
EXW58_RS10095	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW58_RS10100	COG0714	Associated with various cellular activities
EXW58_RS10115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW58_RS10120	COG1140	nitrate reductase beta subunit
EXW58_RS10125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW58_RS10130	COG2181	nitrate reductase activity
EXW58_RS10135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW58_RS10140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW58_RS10145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_RS10150	COG0303	'Molybdopterin
EXW58_RS10155	COG0314	molybdopterin synthase activity
EXW58_RS10165	COG2223	nitrite transmembrane transporter activity
EXW58_RS10170	COG1648	precorrin-2 dehydrogenase activity
EXW58_RS10180	COG1587	Uroporphyrinogen-III synthase
EXW58_RS10180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW58_RS10185	COG2146	nitrite reductase [NAD(P)H] activity
EXW58_RS10190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW58_RS10195	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW58_RS10225	COG2359	stage V sporulation protein S
EXW58_RS10285	COG1418	mRNA catabolic process
EXW58_RS10290	COG0488	(ABC) transporter
EXW58_RS10310	COG1413	lyase activity
EXW58_RS10325	COG2136	Putative SAM-dependent methyltransferase
EXW58_RS10325	COG2521	methyltransferase
EXW58_RS10330	COG0018	arginyl-trna synthetase
EXW58_RS10380	COG0017	Asparaginyl-tRNA synthetase
EXW58_RS10385	COG0733	neurotransmitter:sodium symporter activity
EXW58_RS10390	COG2267	carboxylic ester hydrolase activity
EXW58_RS10410	COG2610	gluconate transmembrane transporter activity
EXW58_RS10415	COG1454	alcohol dehydrogenase
EXW58_RS10425	COG0456	acetyltransferase
EXW58_RS10430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW58_RS10440	COG1131	(ABC) transporter
EXW58_RS10445	COG4473	ABC transporter
EXW58_RS10480	COG0671	phosphoesterase, PA-phosphatase related
EXW58_RS10500	COG0768	penicillin binding
EXW58_RS10515	COG1272	protein, Hemolysin III
EXW58_RS10520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW58_RS10525	COG0805	protein transport
EXW58_RS10535	COG1307	EDD domain protein, DegV family
EXW58_RS10540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW58_RS10545	COG1999	signal sequence binding
EXW58_RS10550	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW58_RS10555	COG0367	asparagine synthase
EXW58_RS10570	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS10575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS10580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS10595	COG1335	isochorismatase
EXW58_RS10600	COG1051	belongs to the nudix hydrolase family
EXW58_RS10605	COG0668	transmembrane transport
EXW58_RS10610	COG4585	Histidine kinase
EXW58_RS10610	COG2203	Gaf domain
EXW58_RS10615	COG2197	response regulator
EXW58_RS10620	COG1737	Transcriptional regulator
EXW58_RS10630	COG4974	Belongs to the 'phage' integrase family
EXW58_RS10640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXW58_RS10645	COG1064	alcohol dehydrogenase
EXW58_RS10660	COG1070	Carbohydrate kinase
EXW58_RS10670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW58_RS10690	COG0517	IMP dehydrogenase activity
EXW58_RS10690	COG1125	glycine betaine transport
EXW58_RS10695	COG1174	glycine betaine transport
EXW58_RS10730	COG1253	flavin adenine dinucleotide binding
EXW58_RS10735	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS10745	COG5506	Protein of unknown function (DUF1694)
EXW58_RS10760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_RS10765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW58_RS10770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW58_RS10775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_RS10780	COG0456	acetyltransferase
EXW58_RS10785	COG3829	transcription factor binding
EXW58_RS10790	COG1509	lysine 2,3-aminomutase activity
EXW58_RS10800	COG4479	Belongs to the UPF0346 family
EXW58_RS10825	COG4991	sh3 domain protein
EXW58_RS10825	COG3064	Membrane
EXW58_RS10825	COG0515	serine threonine protein kinase
EXW58_RS10835	COG0671	phosphoesterase, PA-phosphatase related
EXW58_RS10840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW58_RS10845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS10900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW58_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS10945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_RS10945	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_RS10955	COG2814	Major facilitator Superfamily
EXW58_RS10960	COG0372	Belongs to the citrate synthase family
EXW58_RS10965	COG2079	MmgE PrpD family protein
EXW58_RS10970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW58_RS10975	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS10980	COG2084	Dehydrogenase
EXW58_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS10990	COG1280	lysine exporter protein (LysE YggA)
EXW58_RS10995	COG1024	Enoyl-CoA hydratase
EXW58_RS11010	COG0420	3'-5' exonuclease activity
EXW58_RS11015	COG0419	ATPase involved in DNA repair
EXW58_RS11035	COG2223	nitrite transmembrane transporter activity
EXW58_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS11045	COG1169	isochorismate synthase
EXW58_RS11050	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW58_RS11055	COG3433	isochorismatase activity
EXW58_RS11055	COG1535	isochorismatase
EXW58_RS11060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW58_RS11065	COG3251	PFAM MbtH domain protein
EXW58_RS11070	COG2814	Major facilitator Superfamily
EXW58_RS11085	COG0776	regulation of translation
EXW58_RS11095	COG1115	amino acid carrier protein
EXW58_RS11100	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_RS11110	COG1187	pseudouridine synthase activity
EXW58_RS11115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW58_RS11140	COG1136	(ABC) transporter
EXW58_RS11160	COG0028	Belongs to the TPP enzyme family
EXW58_RS11190	COG1253	flavin adenine dinucleotide binding
EXW58_RS11195	COG3344	reverse transcriptase
EXW58_RS11220	COG2267	carboxylic ester hydrolase activity
EXW58_RS11240	COG1846	Transcriptional regulator
EXW58_RS11250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS11255	COG1309	transcriptional regulator
EXW58_RS11265	COG0697	spore germination
EXW58_RS11270	COG0531	amino acid
EXW58_RS11285	COG1247	-acetyltransferase
EXW58_RS11315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW58_RS11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS11355	COG0561	phosphatase activity
EXW58_RS11365	COG0583	DNA-binding transcription factor activity
EXW58_RS11370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW58_RS11395	COG0583	DNA-binding transcription factor activity
EXW58_RS11400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_RS11405	COG2258	MOSC domain
EXW58_RS11420	COG1132	(ABC) transporter
EXW58_RS11425	COG1132	(ABC) transporter
EXW58_RS11430	COG0582	viral genome integration into host DNA
EXW58_RS11455	COG1396	sequence-specific DNA binding
EXW58_RS11535	COG1309	transcriptional regulator
EXW58_RS11550	COG0577	efflux transmembrane transporter activity
EXW58_RS11550	COG1136	(ABC) transporter
EXW58_RS11555	COG0500	methyltransferase
EXW58_RS11555	COG3615	Tellurite resistance protein tehB
EXW58_RS11565	COG0693	protein deglycase activity
EXW58_RS11575	COG0588	phosphoglycerate mutase activity
EXW58_RS11595	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_RS11600	COG0110	maltose O-acetyltransferase activity
EXW58_RS11605	COG0745	RESPONSE REGULATOR receiver
EXW58_RS11610	COG2205	protein histidine kinase activity
EXW58_RS11615	COG1136	(ABC) transporter
EXW58_RS11620	COG0577	efflux transmembrane transporter activity
EXW58_RS11635	COG1136	(ABC) transporter
EXW58_RS11665	COG1686	Belongs to the peptidase S11 family
EXW58_RS11720	COG0768	penicillin binding
EXW58_RS11725	COG1595	DNA-templated transcription, initiation
EXW58_RS11735	COG0768	penicillin binding
EXW58_RS11740	COG0768	penicillin binding
EXW58_RS11790	COG1131	(ABC) transporter
EXW58_RS11800	COG1309	transcriptional regulator
EXW58_RS11805	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS11810	COG0439	Biotin carboxylase
EXW58_RS11815	COG0511	ligase activity, forming carbon-carbon bonds
EXW58_RS11820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_RS11825	COG1024	Enoyl-CoA hydratase
EXW58_RS11830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW58_RS11835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_RS11885	COG0572	uridine kinase
EXW58_RS11895	COG1686	Belongs to the peptidase S11 family
EXW58_RS11920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS11975	COG1733	regulation of RNA biosynthetic process
EXW58_RS11980	COG2226	methyltransferase
EXW58_RS11990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_RS12005	COG1309	transcriptional regulator
EXW58_RS12030	COG0697	spore germination
EXW58_RS12035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS12070	COG2323	membrane
EXW58_RS12075	COG2132	Multicopper oxidase
EXW58_RS12080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS12085	COG0697	spore germination
EXW58_RS12090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_RS12095	COG0201	protein transport
EXW58_RS12105	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS12110	COG3227	Zinc metalloprotease (Elastase)
EXW58_RS12115	COG1523	belongs to the glycosyl hydrolase 13 family
EXW58_RS12120	COG1073	alpha beta
EXW58_RS12130	COG0577	efflux transmembrane transporter activity
EXW58_RS12135	COG1136	(ABC) transporter
EXW58_RS12170	COG5002	protein histidine kinase activity
EXW58_RS12175	COG0745	RESPONSE REGULATOR receiver
EXW58_RS12180	COG1011	Hydrolase
EXW58_RS12200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_RS12205	COG1183	phosphatidylcholine synthase activity
EXW58_RS12210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW58_RS12220	COG1132	(ABC) transporter
EXW58_RS12235	COG3961	Belongs to the TPP enzyme family
EXW58_RS12255	COG0322	excinuclease ABC activity
EXW58_RS12280	COG2318	DinB family
EXW58_RS12295	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW58_RS12370	COG2223	nitrite transmembrane transporter activity
EXW58_RS12380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_RS12390	COG0494	nUDIX hydrolase
EXW58_RS12435	COG2814	Major facilitator Superfamily
EXW58_RS12475	COG0768	penicillin binding
EXW58_RS12480	COG0671	phosphoesterase, PA-phosphatase related
EXW58_RS12485	COG0604	alcohol dehydrogenase
EXW58_RS12490	COG5002	protein histidine kinase activity
EXW58_RS12495	COG0745	RESPONSE REGULATOR receiver
EXW58_RS12505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_RS12515	COG2205	protein histidine kinase activity
EXW58_RS12535	COG4720	Psort location CytoplasmicMembrane, score
EXW58_RS12540	COG1794	racemase activity, acting on amino acids and derivatives
EXW58_RS12545	COG1819	glycosyl
EXW58_RS12555	COG0768	penicillin binding
EXW58_RS12560	COG5002	protein histidine kinase activity
EXW58_RS12565	COG0561	phosphatase activity
EXW58_RS12600	COG2124	cytochrome p450
EXW58_RS12610	COG3344	reverse transcriptase
EXW58_RS12650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW58_RS12660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS12685	COG0577	efflux transmembrane transporter activity
EXW58_RS12690	COG1136	(ABC) transporter
EXW58_RS12700	COG0488	(ABC) transporter
EXW58_RS12705	COG0667	Aldo Keto reductase
EXW58_RS12710	COG0583	DNA-binding transcription factor activity
EXW58_RS12715	COG2205	protein histidine kinase activity
EXW58_RS12720	COG0745	RESPONSE REGULATOR receiver
EXW58_RS12730	COG3773	Cell wall hydrolase
EXW58_RS12735	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW58_RS12745	COG0604	alcohol dehydrogenase
EXW58_RS12775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS12790	COG2959	enzyme of heme biosynthesis
EXW58_RS12815	COG3483	tryptophan 2,3-dioxygenase activity
EXW58_RS12825	COG3844	kynureninase activity
EXW58_RS12830	COG1309	transcriptional regulator
EXW58_RS12865	COG1349	DNA-binding transcription factor activity
EXW58_RS12895	COG2207	Transcriptional regulator
EXW58_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS12905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_RS12905	COG0456	acetyltransferase
EXW58_RS12915	COG2816	NAD+ diphosphatase activity
EXW58_RS12955	COG4176	ABC-type proline glycine betaine transport system permease component
EXW58_RS12960	COG0517	IMP dehydrogenase activity
EXW58_RS12960	COG4175	Glycine betaine
EXW58_RS12985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW58_RS12990	COG2153	protein acetylation
EXW58_RS12995	COG1819	glycosyl
EXW58_RS13015	COG2205	protein histidine kinase activity
EXW58_RS13020	COG2315	Protein conserved in bacteria
EXW58_RS13065	COG3973	AAA domain
EXW58_RS13070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_RS13080	COG3344	reverse transcriptase
EXW58_RS13090	COG0514	ATP-dependent DNA helicase (RecQ)
EXW58_RS13110	COG4637	Psort location Cytoplasmic, score
EXW58_RS13120	COG1227	inorganic diphosphatase activity
EXW58_RS13125	COG2318	DinB family
EXW58_RS13140	COG1162	GTPase activity
EXW58_RS13150	COG1115	amino acid carrier protein
EXW58_RS13155	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS13160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW58_RS13170	COG3938	Belongs to the proline racemase family
EXW58_RS13175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_RS13220	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS13235	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW58_RS13240	COG4166	transmembrane transport
EXW58_RS13250	COG4948	Mandelate Racemase Muconate Lactonizing
EXW58_RS13270	COG0667	Aldo Keto reductase
EXW58_RS13320	COG2936	dipeptidyl-peptidase activity
EXW58_RS13325	COG5002	protein histidine kinase activity
EXW58_RS13330	COG0745	RESPONSE REGULATOR receiver
EXW58_RS13355	COG1164	Oligoendopeptidase f
EXW58_RS13380	COG1307	EDD domain protein, DegV family
EXW58_RS13415	COG2814	Major facilitator Superfamily
EXW58_RS13425	COG1664	Polymer-forming cytoskeletal
EXW58_RS13430	COG0789	Transcriptional regulator
EXW58_RS13435	COG4533	DNA binding
EXW58_RS13440	COG0477	Major facilitator Superfamily
EXW58_RS13440	COG2814	Major facilitator Superfamily
EXW58_RS13455	COG2261	transglycosylase associated protein
EXW58_RS13470	COG2226	methyltransferase
EXW58_RS13505	COG0436	Aminotransferase
EXW58_RS13510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW58_RS13565	COG0628	permease
EXW58_RS13590	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW58_RS13615	COG0697	spore germination
EXW58_RS13635	COG4912	Dna alkylation repair
EXW58_RS13670	COG2814	Major facilitator Superfamily
EXW58_RS13675	COG1368	sulfuric ester hydrolase activity
EXW58_RS13680	COG0488	(ABC) transporter
EXW58_RS13690	COG1309	transcriptional regulator
EXW58_RS13705	COG0287	Prephenate dehydrogenase
EXW58_RS13720	COG1605	Chorismate mutase
EXW58_RS13720	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW58_RS13765	COG0346	lactoylglutathione lyase activity
EXW58_RS13775	COG0277	FAD linked oxidase domain protein
EXW58_RS13795	COG2610	gluconate transmembrane transporter activity
EXW58_RS13800	COG1024	Enoyl-CoA hydratase
EXW58_RS13810	COG3290	protein histidine kinase activity
EXW58_RS13810	COG3829	transcription factor binding
EXW58_RS13820	COG0579	oxidoreductase
EXW58_RS13825	COG1879	ABC-type sugar transport system periplasmic component
EXW58_RS13835	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW58_RS13845	COG2390	Transcriptional regulator
EXW58_RS13850	COG1070	Carbohydrate kinase
EXW58_RS13865	COG2226	methyltransferase
EXW58_RS13890	COG0346	lactoylglutathione lyase activity
EXW58_RS13895	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_RS13915	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW58_RS13920	COG2207	Transcriptional regulator
EXW58_RS13925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS13930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW58_RS13935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW58_RS13940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_RS13945	COG3239	Fatty acid desaturase
EXW58_RS13955	COG3842	ATPase activity
EXW58_RS13980	COG1175	transmembrane transport
EXW58_RS13985	COG1349	DNA-binding transcription factor activity
EXW58_RS13995	COG3655	Transcriptional regulator
EXW58_RS14015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS14020	COG0346	lactoylglutathione lyase activity
EXW58_RS14045	COG0714	Associated with various cellular activities
EXW58_RS14065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW58_RS14070	COG0753	catalase activity
EXW58_RS14095	COG2801	Transposase and inactivated derivatives
EXW58_RS14120	COG0714	Associated with various cellular activities
EXW58_RS14130	COG0778	Nitroreductase
EXW58_RS14135	COG1846	Transcriptional regulator
EXW58_RS14155	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_RS14170	COG0824	Thioesterase
EXW58_RS14175	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS14180	COG0183	Belongs to the thiolase family
EXW58_RS14185	COG1024	Enoyl-CoA hydratase
EXW58_RS14190	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_RS14195	COG2723	6-phospho-beta-galactosidase activity
EXW58_RS14200	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_RS14205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_RS14220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_RS14230	COG2508	Transcriptional regulator
EXW58_RS14235	COG2814	Major facilitator Superfamily
EXW58_RS14270	COG0577	efflux transmembrane transporter activity
EXW58_RS14270	COG1136	(ABC) transporter
EXW58_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS14290	COG1309	transcriptional regulator
EXW58_RS14315	COG0456	acetyltransferase
EXW58_RS14330	COG0697	spore germination
EXW58_RS14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS14355	COG0642	Histidine kinase
EXW58_RS14360	COG0745	RESPONSE REGULATOR receiver
EXW58_RS14365	COG0596	Alpha beta hydrolase
EXW58_RS14375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_RS14375	COG0456	acetyltransferase
EXW58_RS14410	COG0833	amino acid
EXW58_RS14420	COG4335	DNA alkylation repair
EXW58_RS14445	COG0768	penicillin binding
EXW58_RS14460	COG3104	oligopeptide transport
EXW58_RS14465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW58_RS14480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW58_RS14485	COG1984	allophanate hydrolase subunit 2
EXW58_RS14490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW58_RS14495	COG1414	Transcriptional regulator
EXW58_RS14515	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS14550	COG0640	Transcriptional regulator
EXW58_RS14580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW58_RS14600	COG3848	Pyruvate phosphate dikinase
EXW58_RS14600	COG0574	Belongs to the PEP-utilizing enzyme family
EXW58_RS14650	COG0798	PFAM Bile acid sodium symporter
EXW58_RS14655	COG0346	lactoylglutathione lyase activity
EXW58_RS14660	COG0640	Transcriptional regulator
EXW58_RS14675	COG0346	lactoylglutathione lyase activity
EXW58_RS14690	COG0457	Tetratricopeptide repeat
EXW58_RS14705	COG0745	RESPONSE REGULATOR receiver
EXW58_RS14710	COG3850	Histidine kinase
EXW58_RS14710	COG5002	protein histidine kinase activity
EXW58_RS14750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW58_RS14755	COG3344	reverse transcriptase
EXW58_RS14760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW58_RS14770	COG2309	aminopeptidase activity
EXW58_RS14775	COG2226	methyltransferase
EXW58_RS14780	COG1690	Belongs to the RtcB family
EXW58_RS14795	COG0789	Transcriptional regulator
EXW58_RS14810	COG0277	FAD linked oxidase domain protein
EXW58_RS14815	COG1136	(ABC) transporter
EXW58_RS14820	COG0577	efflux transmembrane transporter activity
EXW58_RS14835	COG5002	protein histidine kinase activity
EXW58_RS14835	COG3850	Histidine kinase
EXW58_RS14850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS14890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW58_RS14910	COG1595	DNA-templated transcription, initiation
EXW58_RS14960	COG2814	Major facilitator Superfamily
EXW58_RS14990	COG1876	peptidase activity
EXW58_RS14995	COG2843	Capsule synthesis protein
EXW58_RS15010	COG0477	Major facilitator Superfamily
EXW58_RS15025	COG1846	Transcriptional regulator
EXW58_RS15030	COG2814	Major facilitator Superfamily
EXW58_RS15045	COG2814	Major facilitator Superfamily
EXW58_RS15115	COG0384	phenazine biosynthesis protein PhzF
EXW58_RS15155	COG4187	Peptidase family M20/M25/M40
EXW58_RS15160	COG1414	Transcriptional regulator
EXW58_RS15165	COG0833	amino acid
EXW58_RS15185	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW58_RS15235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW58_RS15240	COG2356	endonuclease I
EXW58_RS15245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_RS15255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW58_RS15275	COG1785	Belongs to the alkaline phosphatase family
EXW58_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS15305	COG1131	(ABC) transporter
EXW58_RS15330	COG1011	Hydrolase
EXW58_RS15335	COG2365	Tyrosine phosphatase family
EXW58_RS15360	COG0346	lactoylglutathione lyase activity
EXW58_RS15365	COG1940	carbohydrate kinase activity
EXW58_RS15370	COG0738	Major facilitator superfamily
EXW58_RS15375	COG0110	maltose O-acetyltransferase activity
EXW58_RS15390	COG0628	permease
EXW58_RS15410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW58_RS15415	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW58_RS15425	COG1253	flavin adenine dinucleotide binding
EXW58_RS15430	COG0789	Transcriptional regulator
EXW58_RS15435	COG0697	spore germination
EXW58_RS15445	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW58_RS15450	COG3813	Protein conserved in bacteria
EXW58_RS15455	COG4702	Belongs to the UPF0303 family
EXW58_RS15465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS15480	COG0494	nUDIX hydrolase
EXW58_RS15505	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW58_RS15510	COG1733	regulation of RNA biosynthetic process
EXW58_RS15525	COG1191	sigma factor activity
EXW58_RS15560	COG5002	protein histidine kinase activity
EXW58_RS15600	COG0814	amino acid
EXW58_RS15620	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS15625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW58_RS15630	COG3800	Transcriptional regulator
EXW58_RS15630	COG1396	sequence-specific DNA binding
EXW58_RS15660	COG1151	hydroxylamine reductase activity
EXW58_RS15690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_RS15700	COG2072	flavoprotein involved in K transport
EXW58_RS15745	COG0604	alcohol dehydrogenase
EXW58_RS15750	COG1113	amino acid transport
EXW58_RS15765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_RS15780	COG0534	Mate efflux family protein
EXW58_RS15785	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS15790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_RS15805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_RS15825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS15830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS15835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS15840	COG3739	integral membrane protein
EXW58_RS15855	COG0583	DNA-binding transcription factor activity
EXW58_RS15875	COG1193	negative regulation of DNA recombination
EXW58_RS15885	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW58_RS15890	COG1164	Oligoendopeptidase f
EXW58_RS15915	COG3781	membrane
EXW58_RS15930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_RS15950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW58_RS15955	COG0457	Tetratricopeptide repeat
EXW58_RS15965	COG2808	Putative FMN-binding domain
EXW58_RS15975	COG0277	FAD linked oxidase domain protein
EXW58_RS15995	COG2514	catechol 2,3-dioxygenase activity
EXW58_RS16000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS16005	COG1126	abc transporter atp-binding protein
EXW58_RS16010	COG0765	amino acid transport
EXW58_RS16015	COG2720	vancomycin resistance protein
EXW58_RS16030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW58_RS16030	COG4451	ribulose bisphosphate carboxylase, small
EXW58_RS16050	COG1278	Cold shock
EXW58_RS16060	COG0716	FMN binding
EXW58_RS16070	COG1051	belongs to the nudix hydrolase family
EXW58_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS16090	COG0165	Argininosuccinate lyase
EXW58_RS16105	COG4145	pantothenate transmembrane transporter activity
EXW58_RS16115	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS16130	COG1657	PFAM Prenyltransferase squalene oxidase
EXW58_RS16135	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW58_RS16140	COG2962	Rard protein
EXW58_RS16145	COG3326	Membrane
EXW58_RS16150	COG0531	amino acid
EXW58_RS16185	COG2226	methyltransferase
EXW58_RS16190	COG4166	transmembrane transport
EXW58_RS16195	COG4166	transmembrane transport
EXW58_RS16200	COG4166	transmembrane transport
EXW58_RS16205	COG1316	TRANSCRIPTIONal
EXW58_RS16215	COG1595	DNA-templated transcription, initiation
EXW58_RS16225	COG1131	(ABC) transporter
EXW58_RS16235	COG0673	inositol 2-dehydrogenase activity
EXW58_RS16240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW58_RS16245	COG0187	DNA topoisomerase II activity
EXW58_RS16250	COG1832	CoA-binding protein
EXW58_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_RS16260	COG0745	RESPONSE REGULATOR receiver
EXW58_RS16270	COG1328	CTP reductase activity
EXW58_RS16280	COG4841	protein insertion into membrane
EXW58_RS16285	COG0824	Thioesterase
EXW58_RS16310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS16330	COG1266	CAAX protease self-immunity
EXW58_RS16335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW58_RS16365	COG2211	Major facilitator Superfamily
EXW58_RS16375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW58_RS16410	COG0183	Belongs to the thiolase family
EXW58_RS16420	COG1268	BioY protein
EXW58_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS16470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS16480	COG5002	protein histidine kinase activity
EXW58_RS16485	COG0400	carboxylic ester hydrolase activity
EXW58_RS16495	COG0069	glutamate synthase activity
EXW58_RS16500	COG1902	pentaerythritol trinitrate reductase activity
EXW58_RS16505	COG1329	Transcriptional regulator
EXW58_RS16510	COG0010	Belongs to the arginase family
EXW58_RS16520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW58_RS16525	COG2986	histidine ammonia-lyase
EXW58_RS16535	COG2226	methyltransferase
EXW58_RS16560	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW58_RS16565	COG0785	Cytochrome C biogenesis protein
EXW58_RS16575	COG1473	amidohydrolase
EXW58_RS16580	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_RS16585	COG1131	(ABC) transporter
EXW58_RS16600	COG0583	DNA-binding transcription factor activity
EXW58_RS16610	COG1346	cytolysis
EXW58_RS16640	COG1132	(ABC) transporter
EXW58_RS16645	COG1132	(ABC) transporter
EXW58_RS16650	COG3763	UPF0154 protein
EXW58_RS16665	COG3639	organic phosphonate transmembrane transporter activity
EXW58_RS16670	COG3639	organic phosphonate transmembrane transporter activity
EXW58_RS16680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS16685	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS16695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW58_RS16700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW58_RS16715	COG1695	Transcriptional regulator
EXW58_RS16720	COG1132	(ABC) transporter
EXW58_RS16750	COG0367	asparagine synthase
EXW58_RS16755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW58_RS16765	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW58_RS16770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_RS16820	COG3344	reverse transcriptase
EXW58_RS16835	COG0463	Glycosyl transferase, family 2
EXW58_RS16835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_RS16840	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS16845	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS16850	COG1086	Polysaccharide biosynthesis protein
EXW58_RS16855	COG0489	protein tyrosine kinase activity
EXW58_RS16865	COG0174	glutamine synthetase
EXW58_RS16870	COG0789	Transcriptional regulator
EXW58_RS16875	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW58_RS16880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW58_RS16885	COG2860	membrane
EXW58_RS16895	COG0464	growth
EXW58_RS16920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW58_RS16930	COG1388	LysM domain
EXW58_RS16930	COG3584	3D domain protein
EXW58_RS16935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW58_RS16935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW58_RS16935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_RS16940	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW58_RS16945	COG1349	DNA-binding transcription factor activity
EXW58_RS16950	COG1979	alcohol dehydrogenase
EXW58_RS16955	COG2322	membrane
EXW58_RS16965	COG1473	amidohydrolase
EXW58_RS16970	COG1408	metallophosphoesterase
EXW58_RS16975	COG2116	formate transmembrane transporter activity
EXW58_RS16990	COG2217	Heavy metal translocating P-type atpase
EXW58_RS16995	COG2608	mercury ion transmembrane transporter activity
EXW58_RS17000	COG1937	Protein conserved in bacteria
EXW58_RS17030	COG2819	hydrolase of the alpha beta superfamily
EXW58_RS17035	COG1120	ATPase activity
EXW58_RS17040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS17045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS17050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS17055	COG0708	Exodeoxyribonuclease III
EXW58_RS17060	COG2169	Transcriptional regulator
EXW58_RS17065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW58_RS17070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW58_RS17075	COG2706	6-phosphogluconolactonase activity
EXW58_RS17080	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_RS17085	COG2364	Membrane
EXW58_RS17100	COG0346	lactoylglutathione lyase activity
EXW58_RS17105	COG3300	MHYT domain
EXW58_RS17105	COG5001	Diguanylate cyclase
EXW58_RS17145	COG1346	cytolysis
EXW58_RS17155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_RS17160	COG2945	thiolester hydrolase activity
EXW58_RS17160	COG0596	Alpha beta hydrolase
EXW58_RS17165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_RS17175	COG3344	reverse transcriptase
EXW58_RS17180	COG2188	Transcriptional regulator
EXW58_RS17185	COG2723	6-phospho-beta-galactosidase activity
EXW58_RS17195	COG3773	Cell wall hydrolase
EXW58_RS17205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_RS17215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW58_RS17220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW58_RS17230	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW58_RS17235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW58_RS17240	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW58_RS17245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW58_RS17245	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW58_RS17255	COG2359	stage V sporulation protein S
EXW58_RS17260	COG1692	metallophosphoesterase
EXW58_RS17265	COG1418	mRNA catabolic process
EXW58_RS17285	COG1546	Belongs to the CinA family
EXW58_RS17285	COG1058	Belongs to the CinA family
EXW58_RS17290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW58_RS17295	COG1426	Protein conserved in bacteria
EXW58_RS17310	COG0300	oxidoreductase activity
EXW58_RS17315	COG0612	Peptidase, M16
EXW58_RS17320	COG0612	Peptidase, M16
EXW58_RS17325	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW58_RS17330	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW58_RS17335	COG3845	ABC transporter
EXW58_RS17340	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW58_RS17345	COG2188	Transcriptional regulator
EXW58_RS17355	COG1674	ftsk spoiiie
EXW58_RS17365	COG0740	serine-type endopeptidase activity
EXW58_RS17370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_RS17380	COG0527	aspartate kinase activity
EXW58_RS17385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW58_RS17390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW58_RS17395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW58_RS17400	COG1873	PFAM PRC-barrel domain
EXW58_RS17405	COG0612	Peptidase, M16
EXW58_RS17410	COG0726	polysaccharide deacetylase
EXW58_RS17415	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW58_RS17425	COG0196	riboflavin kinase activity
EXW58_RS17435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW58_RS17440	COG1550	Protein conserved in bacteria
EXW58_RS17445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW58_RS17450	COG1358	cellular component organization or biogenesis
EXW58_RS17455	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW58_RS17460	COG0195	Participates in both transcription termination and antitermination
EXW58_RS17475	COG0442	prolyl-tRNA aminoacylation
EXW58_RS17480	COG0750	zinc metalloprotease
EXW58_RS17490	COG4589	Belongs to the CDS family
EXW58_RS17500	COG0233	cytoplasmic translational termination
EXW58_RS17505	COG0528	UMP kinase activity
EXW58_RS17510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW58_RS17515	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW58_RS17520	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW58_RS17525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW58_RS17530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW58_RS17535	COG4974	Belongs to the 'phage' integrase family
EXW58_RS17540	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW58_RS17545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW58_RS17550	COG0758	DNA mediated transformation
EXW58_RS17555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW58_RS17560	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW58_RS17565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW58_RS17580	COG0335	large ribosomal subunit rRNA binding
EXW58_RS17585	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW58_RS17590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW58_RS17595	COG1837	Belongs to the UPF0109 family
EXW58_RS17605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW58_RS17615	COG0552	protein localization to endoplasmic reticulum
EXW58_RS17620	COG1196	nuclear chromosome segregation
EXW58_RS17625	COG0571	ribonuclease III activity
EXW58_RS17630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS17640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW58_RS17645	COG0416	fatty acid biosynthetic process
EXW58_RS17655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW58_RS17660	COG1461	Dihydroxyacetone kinase
EXW58_RS17665	COG1302	Protein conserved in bacteria
EXW58_RS17680	COG1564	THIamine pyrophosphokinase
EXW58_RS17685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW58_RS17695	COG0515	serine threonine protein kinase
EXW58_RS17695	COG2815	serine threonine protein kinase
EXW58_RS17700	COG0631	protein serine/threonine phosphatase activity
EXW58_RS17705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW58_RS17710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW58_RS17710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW58_RS17715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW58_RS17720	COG0242	peptide deformylase activity
EXW58_RS17725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW58_RS17730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW58_RS17735	COG1758	RNA polymerase activity
EXW58_RS17750	COG1561	YicC-like family, N-terminal region
EXW58_RS17755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW58_RS17770	COG0006	proline dipeptidase activity
EXW58_RS17785	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW58_RS17810	COG0167	dihydroorotate dehydrogenase activity
EXW58_RS17815	COG0543	2 iron, 2 sulfur cluster binding
EXW58_RS17820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW58_RS17830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW58_RS17835	COG0540	Belongs to the ATCase OTCase family
EXW58_RS17845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW58_RS17850	COG0564	pseudouridine synthase activity
EXW58_RS17870	COG3599	regulation of cell shape
EXW58_RS17875	COG2302	S4 RNA-binding domain
EXW58_RS17880	COG0762	integral membrane protein
EXW58_RS17885	COG1799	cell septum assembly
EXW58_RS17890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW58_RS17900	COG1873	PFAM PRC-barrel domain
EXW58_RS17905	COG1191	sigma factor activity
EXW58_RS17910	COG1191	sigma factor activity
EXW58_RS17920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW58_RS17925	COG0849	cell division
EXW58_RS17930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW58_RS17945	COG0772	Belongs to the SEDS family
EXW58_RS17950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW58_RS17955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW58_RS17960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW58_RS17965	COG0768	penicillin binding
EXW58_RS17970	COG0768	penicillin binding
EXW58_RS17980	COG0275	rRNA processing
EXW58_RS17985	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW58_RS17990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW58_RS17995	COG0454	-acetyltransferase
EXW58_RS18005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW58_RS18010	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW58_RS18015	COG1323	Belongs to the UPF0348 family
EXW58_RS18020	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW58_RS18025	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW58_RS18030	COG3314	Sporulation integral membrane protein YlbJ
EXW58_RS18040	COG0742	ribosomal rna small subunit methyltransferase
EXW58_RS18050	COG4471	UPF0298 protein
EXW58_RS18055	COG3679	Belongs to the UPF0342 family
EXW58_RS18060	COG0406	alpha-ribazole phosphatase activity
EXW58_RS18075	COG2340	Cysteine-rich secretory protein family
EXW58_RS18085	COG3336	cytochrome c oxidase
EXW58_RS18110	COG0109	protoheme IX farnesyltransferase activity
EXW58_RS18115	COG1612	heme a metabolic process
EXW58_RS18120	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW58_RS18125	COG0772	Belongs to the SEDS family
EXW58_RS18130	COG4838	Belongs to the UPF0358 family
EXW58_RS18135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW58_RS18140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW58_RS18150	COG4896	Protein conserved in bacteria
EXW58_RS18165	COG1217	gtp-binding protein TYPA
EXW58_RS18175	COG0483	inositol monophosphate 1-phosphatase activity
EXW58_RS18185	COG4493	Belongs to the UPF0637 family
EXW58_RS18190	COG4476	Belongs to the UPF0223 family
EXW58_RS18195	COG1982	Orn Lys Arg decarboxylase major
EXW58_RS18240	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_RS18245	COG0022	dehydrogenase e1 component
EXW58_RS18250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW58_RS18265	COG0561	phosphatase activity
EXW58_RS18270	COG5503	Protein of unknown function (DUF1447)
EXW58_RS18275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_RS18280	COG0569	domain protein
EXW58_RS18290	COG1473	amidohydrolase
EXW58_RS18295	COG2171	N-acyltransferase activity
EXW58_RS18300	COG0583	DNA-binding transcription factor activity
EXW58_RS18305	COG0517	IMP dehydrogenase activity
EXW58_RS18315	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW58_RS18325	COG4703	Protein of unknown function (DUF1797)
EXW58_RS18340	COG2200	EAL domain
EXW58_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS18350	COG1408	metallophosphoesterase
EXW58_RS18395	COG2814	Major facilitator Superfamily
EXW58_RS18405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW58_RS18415	COG3209	COG3209 Rhs family protein
EXW58_RS18425	COG2205	protein histidine kinase activity
EXW58_RS18435	COG0436	Aminotransferase
EXW58_RS18440	COG1609	Transcriptional regulator
EXW58_RS18445	COG3833	ABC-type maltose transport systems, permease component
EXW58_RS18450	COG1175	transmembrane transport
EXW58_RS18455	COG2182	Extracellular solute-binding protein
EXW58_RS18465	COG0366	Alpha amylase catalytic
EXW58_RS18470	COG3842	ATPase activity
EXW58_RS18510	COG0183	Belongs to the thiolase family
EXW58_RS18545	COG1695	Transcriptional regulator
EXW58_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS18560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW58_RS18570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW58_RS18575	COG0436	Aminotransferase
EXW58_RS18580	COG1850	ribulose-bisphosphate carboxylase activity
EXW58_RS18585	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW58_RS18590	COG0235	Class ii aldolase
EXW58_RS18595	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW58_RS18610	COG2084	Dehydrogenase
EXW58_RS18620	COG2199	diguanylate cyclase activity
EXW58_RS18625	COG0778	Nitroreductase
EXW58_RS18650	COG1263	PTS System
EXW58_RS18650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS18650	COG2190	(PTS) system
EXW58_RS18655	COG3711	transcriptional antiterminator
EXW58_RS18665	COG2188	Transcriptional regulator
EXW58_RS18670	COG0363	glucosamine-6-phosphate deaminase activity
EXW58_RS18675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW58_RS18685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW58_RS18690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW58_RS18700	COG1547	Domain of unknown function (DUF309)
EXW58_RS18710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW58_RS18715	COG4086	secreted protein
EXW58_RS18720	COG0561	phosphatase activity
EXW58_RS18730	COG0697	spore germination
EXW58_RS18745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_RS18785	COG1686	Belongs to the peptidase S11 family
EXW58_RS18790	COG1725	Transcriptional regulator
EXW58_RS18795	COG1131	(ABC) transporter
EXW58_RS18815	COG1846	Transcriptional regulator
EXW58_RS18830	COG0598	Magnesium transport protein CorA
EXW58_RS18845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW58_RS18855	COG4974	Belongs to the 'phage' integrase family
EXW58_RS18865	COG0735	belongs to the Fur family
EXW58_RS18870	COG1300	Membrane
EXW58_RS18890	COG0667	Aldo Keto reductase
EXW58_RS18895	COG0656	L-ascorbic acid biosynthetic process
EXW58_RS18900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_RS18900	COG0456	acetyltransferase
EXW58_RS18910	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS18910	COG1525	nuclease
EXW58_RS18910	COG4085	toxin activity
EXW58_RS18915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW58_RS18925	COG0596	Alpha beta hydrolase
EXW58_RS18930	COG2056	Na+-H+ antiporter family
EXW58_RS18935	COG1609	Transcriptional regulator
EXW58_RS18940	COG0456	acetyltransferase
EXW58_RS18945	COG1073	alpha beta
EXW58_RS18960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW58_RS18960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW58_RS18965	COG0307	riboflavin synthase, alpha
EXW58_RS18970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW58_RS18970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW58_RS18985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW58_RS18995	COG1073	alpha beta
EXW58_RS18995	COG2226	methyltransferase
EXW58_RS19000	COG0156	8-amino-7-oxononanoate synthase activity
EXW58_RS19010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_RS19020	COG1757	Na H antiporter
EXW58_RS19030	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS19040	COG1522	sequence-specific DNA binding
EXW58_RS19060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW58_RS19065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW58_RS19075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW58_RS19085	COG0300	oxidoreductase activity
EXW58_RS19090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS19095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_RS19100	COG1760	l-serine dehydratase
EXW58_RS19105	COG1760	l-serine dehydratase
EXW58_RS19115	COG1234	tRNA 3'-trailer cleavage
EXW58_RS19145	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_RS19150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS19165	COG1376	ErfK ybiS ycfS ynhG family protein
EXW58_RS19170	COG4129	membrane
EXW58_RS19175	COG1126	abc transporter atp-binding protein
EXW58_RS19180	COG0765	amino acid transport
EXW58_RS19185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_RS19195	COG2816	NAD+ diphosphatase activity
EXW58_RS19200	COG2323	membrane
EXW58_RS19205	COG0772	Belongs to the SEDS family
EXW58_RS19210	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_RS19215	COG0022	dehydrogenase e1 component
EXW58_RS19220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW58_RS19225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW58_RS19230	COG3426	butyrate kinase activity
EXW58_RS19240	COG0280	phosphate acetyltransferase
EXW58_RS19245	COG3829	transcription factor binding
EXW58_RS19245	COG3290	protein histidine kinase activity
EXW58_RS19255	COG0584	glycerophosphoryl diester phosphodiesterase
EXW58_RS19260	COG3093	addiction module antidote protein HigA
EXW58_RS19265	COG3344	reverse transcriptase
EXW58_RS19275	COG0745	RESPONSE REGULATOR receiver
EXW58_RS19285	COG0750	zinc metalloprotease
EXW58_RS19290	COG0497	DNA recombination
EXW58_RS19295	COG1438	arginine binding
EXW58_RS19300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW58_RS19305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW58_RS19310	COG0142	geranyltranstransferase activity
EXW58_RS19315	COG1722	exodeoxyribonuclease VII activity
EXW58_RS19325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW58_RS19330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW58_RS19335	COG1302	Protein conserved in bacteria
EXW58_RS19340	COG0439	Biotin carboxylase
EXW58_RS19345	COG0511	ligase activity, forming carbon-carbon bonds
EXW58_RS19390	COG3854	ATPases associated with a variety of cellular activities
EXW58_RS19410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW58_RS19415	COG0006	proline dipeptidase activity
EXW58_RS19430	COG3872	metal-dependent enzyme
EXW58_RS19440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW58_RS19465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_RS19475	COG1609	Transcriptional regulator
EXW58_RS19485	COG2076	Multidrug Resistance protein
EXW58_RS19490	COG2076	Multidrug Resistance protein
EXW58_RS19525	COG1725	Transcriptional regulator
EXW58_RS19540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW58_RS19545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW58_RS19550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW58_RS19555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_RS19585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW58_RS19610	COG4970	Tfp pilus assembly protein FimT
EXW58_RS19615	COG4537	Required for transformation and DNA binding
EXW58_RS19620	COG1459	type II secretion system
EXW58_RS19625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW58_RS19680	COG1410	methionine synthase
EXW58_RS19680	COG0646	methionine synthase
EXW58_RS19685	COG0646	methionine synthase
EXW58_RS19685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW58_RS19690	COG0626	cystathionine gamma-synthase activity
EXW58_RS19695	COG0626	cystathionine gamma-synthase activity
EXW58_RS19715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS19725	COG1940	carbohydrate kinase activity
EXW58_RS19730	COG4483	Protein conserved in bacteria
EXW58_RS19735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW58_RS19740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW58_RS19745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW58_RS19750	COG0704	Plays a role in the regulation of phosphate uptake
EXW58_RS19760	COG0581	inorganic phosphate transmembrane transporter activity
EXW58_RS19765	COG0573	inorganic phosphate transmembrane transporter activity
EXW58_RS19770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW58_RS19775	COG0768	penicillin binding
EXW58_RS19780	COG0477	Major facilitator Superfamily
EXW58_RS19785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW58_RS19805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW58_RS19810	COG0735	belongs to the Fur family
EXW58_RS19815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW58_RS19820	COG1121	(ABC) transporter
EXW58_RS19825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS19835	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW58_RS19855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW58_RS19860	COG2384	SAM-dependent methyltransferase
EXW58_RS19865	COG2010	Cytochrome c
EXW58_RS19870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW58_RS19875	COG0358	DNA primase activity
EXW58_RS19885	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW58_RS19890	COG0517	IMP dehydrogenase activity
EXW58_RS19895	COG1381	Involved in DNA repair and RecF pathway recombination
EXW58_RS19905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW58_RS19910	COG0295	cytidine deaminase activity
EXW58_RS19915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW58_RS19920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW58_RS19925	COG1480	7TM receptor with intracellular HD hydrolase
EXW58_RS19930	COG1702	phosphate starvation-inducible protein PhoH
EXW58_RS19945	COG1610	YqeY-like protein
EXW58_RS19950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW58_RS19955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW58_RS19960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW58_RS19970	COG0484	heat shock protein binding
EXW58_RS19975	COG0443	Heat shock 70 kDa protein
EXW58_RS19985	COG1420	regulation of RNA biosynthetic process
EXW58_RS19990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW58_RS19995	COG1733	regulation of RNA biosynthetic process
EXW58_RS20000	COG0481	GTPase activity
EXW58_RS20010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW58_RS20015	COG0268	Binds directly to 16S ribosomal RNA
EXW58_RS20020	COG1466	dna polymerase III delta subunit
EXW58_RS20030	COG0658	competence protein
EXW58_RS20030	COG2333	competence protein COMEC
EXW58_RS20035	COG2131	deaminase
EXW58_RS20040	COG1555	photosystem II stabilization
EXW58_RS20040	COG1596	polysaccharide export
EXW58_RS20045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_RS20050	COG2226	methyltransferase
EXW58_RS20055	COG0799	negative regulation of ribosome biogenesis
EXW58_RS20060	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW58_RS20065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW58_RS20070	COG1534	Rna-binding protein
EXW58_RS20075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW58_RS20080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW58_RS20085	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW58_RS20095	COG0688	phosphatidylethanolamine metabolic process
EXW58_RS20115	COG2357	RelA SpoT domain protein
EXW58_RS20125	COG1785	Belongs to the alkaline phosphatase family
EXW58_RS20135	COG2267	carboxylic ester hydrolase activity
EXW58_RS20170	COG1404	Belongs to the peptidase S8 family
EXW58_RS20175	COG3186	Phenylalanine-4-hydroxylase
EXW58_RS20185	COG2514	catechol 2,3-dioxygenase activity
EXW58_RS20190	COG2259	Doxx family
EXW58_RS20230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW58_RS20240	COG1454	alcohol dehydrogenase
EXW58_RS20240	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS20245	COG0626	cystathionine gamma-synthase activity
EXW58_RS20250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_RS20255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_RS20260	COG2226	methyltransferase
EXW58_RS20275	COG0768	penicillin binding
EXW58_RS20280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW58_RS20285	COG0572	uridine kinase
EXW58_RS20290	COG0826	peptidase U32
EXW58_RS20295	COG0826	peptidase U32
EXW58_RS20300	COG4122	O-methyltransferase activity
EXW58_RS20305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW58_RS20315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW58_RS20325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW58_RS20330	COG0628	permease
EXW58_RS20350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW58_RS20360	COG0482	sulfurtransferase activity
EXW58_RS20365	COG1104	cysteine desulfurase activity
EXW58_RS20370	COG1959	2 iron, 2 sulfur cluster binding
EXW58_RS20375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW58_RS20385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW58_RS20390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW58_RS20405	COG1490	D-aminoacyl-tRNA deacylase activity
EXW58_RS20410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW58_RS20415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW58_RS20420	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW58_RS20420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW58_RS20425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW58_RS20430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW58_RS20430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW58_RS20440	COG2244	polysaccharide biosynthetic process
EXW58_RS20445	COG2323	membrane
EXW58_RS20455	COG1862	Preprotein translocase
EXW58_RS20460	COG0343	queuine tRNA-ribosyltransferase activity
EXW58_RS20475	COG2255	four-way junction helicase activity
EXW58_RS20480	COG0632	four-way junction helicase activity
EXW58_RS20485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW58_RS20510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW58_RS20515	COG0157	Belongs to the NadC ModD family
EXW58_RS20520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW58_RS20525	COG1104	cysteine desulfurase activity
EXW58_RS20530	COG1827	regulation of RNA biosynthetic process
EXW58_RS20535	COG2258	MOSC domain
EXW58_RS20540	COG0077	Prephenate dehydratase
EXW58_RS20545	COG0577	efflux transmembrane transporter activity
EXW58_RS20550	COG0577	efflux transmembrane transporter activity
EXW58_RS20555	COG1136	(ABC) transporter
EXW58_RS20560	COG5002	protein histidine kinase activity
EXW58_RS20565	COG0745	RESPONSE REGULATOR receiver
EXW58_RS20570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW58_RS20575	COG3290	protein histidine kinase activity
EXW58_RS20585	COG2868	ribosomal protein
EXW58_RS20595	COG1530	ribonuclease E activity
EXW58_RS20600	COG1994	Peptidase M50
EXW58_RS20605	COG0739	heme binding
EXW58_RS20610	COG2894	cell division
EXW58_RS20615	COG0850	regulation of cytokinetic process
EXW58_RS20630	COG1077	Cell shape determining protein MreB Mrl
EXW58_RS20635	COG2003	Belongs to the UPF0758 family
EXW58_RS20640	COG0424	maF-like protein
EXW58_RS20650	COG0285	dihydrofolate synthase activity
EXW58_RS20665	COG1388	LysM domain
EXW58_RS20670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW58_RS20675	COG0113	porphobilinogen synthase activity
EXW58_RS20680	COG1587	Uroporphyrinogen-III synthase
EXW58_RS20685	COG0181	hydroxymethylbilane synthase activity
EXW58_RS20690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW58_RS20695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW58_RS20700	COG1846	Transcriptional regulator
EXW58_RS20705	COG1764	response to oxidative stress
EXW58_RS20710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW58_RS20720	COG0470	DNA polymerase III
EXW58_RS20720	COG1067	ATP-dependent peptidase activity
EXW58_RS20730	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_RS20760	COG0622	Phosphoesterase
EXW58_RS20770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW58_RS20775	COG5401	PFAM Sporulation and spore germination
EXW58_RS20795	COG2197	response regulator
EXW58_RS20800	COG2233	PERMEase
EXW58_RS20805	COG0402	S-adenosylhomocysteine deaminase activity
EXW58_RS20810	COG1983	PspC domain protein
EXW58_RS20815	COG1396	sequence-specific DNA binding
EXW58_RS20820	COG0697	spore germination
EXW58_RS20830	COG1959	2 iron, 2 sulfur cluster binding
EXW58_RS20835	COG1668	transmembrane transport
EXW58_RS20840	COG4152	abc transporter atp-binding protein
EXW58_RS20845	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW58_RS20850	COG1360	Flagellar Motor Protein
EXW58_RS20855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW58_RS20860	COG1876	peptidase activity
EXW58_RS20865	COG0824	Thioesterase
EXW58_RS20870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW58_RS20875	COG1053	succinate dehydrogenase
EXW58_RS20880	COG2009	succinate dehydrogenase
EXW58_RS20885	COG1719	4-vinyl reductase, 4VR
EXW58_RS20890	COG0322	excinuclease ABC activity
EXW58_RS20895	COG3118	belongs to the thioredoxin family
EXW58_RS20900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW58_RS20905	COG2086	electron transfer activity
EXW58_RS20910	COG1024	Enoyl-CoA hydratase
EXW58_RS20915	COG1309	transcriptional regulator
EXW58_RS20920	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS20930	COG2318	DinB family
EXW58_RS20960	COG1131	(ABC) transporter
EXW58_RS20965	COG2205	protein histidine kinase activity
EXW58_RS20970	COG0745	RESPONSE REGULATOR receiver
EXW58_RS20980	COG4895	conserved protein (DUF2196)
EXW58_RS20985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW58_RS20995	COG4509	Sortase family
EXW58_RS21000	COG1120	ATPase activity
EXW58_RS21015	COG5386	Cell surface protein
EXW58_RS21020	COG5386	Cell surface protein
EXW58_RS21025	COG1114	Component of the transport system for branched-chain amino acids
EXW58_RS21030	COG1187	pseudouridine synthase activity
EXW58_RS21035	COG1193	negative regulation of DNA recombination
EXW58_RS21040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW58_RS21040	COG1796	DNA polymerase
EXW58_RS21045	COG1286	toxin biosynthetic process
EXW58_RS21050	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW58_RS21055	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW58_RS21080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW58_RS21085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW58_RS21095	COG1418	mRNA catabolic process
EXW58_RS21115	COG2814	Major facilitator Superfamily
EXW58_RS21120	COG1566	PFAM secretion protein HlyD family protein
EXW58_RS21125	COG1309	transcriptional regulator
EXW58_RS21130	COG1363	Peptidase, m42
EXW58_RS21140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW58_RS21155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW58_RS21165	COG1484	DNA-dependent DNA replication
EXW58_RS21170	COG3611	Membrane attachment protein
EXW58_RS21175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW58_RS21180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW58_RS21185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW58_RS21190	COG0237	dephospho-CoA kinase activity
EXW58_RS21195	COG1971	Probably functions as a manganese efflux pump
EXW58_RS21205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_RS21205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_RS21210	COG5002	protein histidine kinase activity
EXW58_RS21215	COG0745	RESPONSE REGULATOR receiver
EXW58_RS21235	COG0538	isocitrate dehydrogenase activity
EXW58_RS21240	COG0372	Belongs to the citrate synthase family
EXW58_RS21250	COG0628	permease
EXW58_RS21255	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW58_RS21265	COG0205	6-phosphofructokinase activity
EXW58_RS21280	COG1725	Transcriptional regulator
EXW58_RS21285	COG0281	malic enzyme
EXW58_RS21290	COG0587	DNA-directed DNA polymerase activity
EXW58_RS21305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW58_RS21320	COG4109	DRTGG domain
EXW58_RS21330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW58_RS21335	COG0006	proline dipeptidase activity
EXW58_RS21385	COG0662	Cupin 2, conserved barrel domain protein
EXW58_RS21395	COG1476	TRANSCRIPTIONal
EXW58_RS21410	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS21415	COG0589	response to stress
EXW58_RS21435	COG0165	Argininosuccinate lyase
EXW58_RS21440	COG0137	argininosuccinate synthase activity
EXW58_RS21455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS21470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW58_RS21475	COG0827	DNA restriction-modification system
EXW58_RS21480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW58_RS21485	COG3874	Sporulation protein YtfJ
EXW58_RS21500	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW58_RS21510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_RS21525	COG1104	cysteine desulfurase activity
EXW58_RS21530	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW58_RS21545	COG1309	transcriptional regulator
EXW58_RS21550	COG1956	GAF domain-containing protein
EXW58_RS21555	COG0626	cystathionine gamma-synthase activity
EXW58_RS21560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW58_RS21600	COG1595	DNA-templated transcription, initiation
EXW58_RS21610	COG0110	maltose O-acetyltransferase activity
EXW58_RS21615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_RS21620	COG0454	-acetyltransferase
EXW58_RS21625	COG0517	IMP dehydrogenase activity
EXW58_RS21630	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW58_RS21645	COG0745	RESPONSE REGULATOR receiver
EXW58_RS21650	COG5002	protein histidine kinase activity
EXW58_RS21655	COG0666	response to abiotic stimulus
EXW58_RS21685	COG1609	Transcriptional regulator
EXW58_RS21690	COG4851	CamS sex pheromone cAM373 precursor
EXW58_RS21695	COG3118	belongs to the thioredoxin family
EXW58_RS21705	COG2309	aminopeptidase activity
EXW58_RS21725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS21730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW58_RS21740	COG1674	ftsk spoiiie
EXW58_RS21755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW58_RS21760	COG4848	Belongs to the UPF0354 family
EXW58_RS21765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS21770	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW58_RS21775	COG1363	Peptidase, m42
EXW58_RS21785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS21790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW58_RS21800	COG0510	thiamine kinase activity
EXW58_RS21805	COG1523	belongs to the glycosyl hydrolase 13 family
EXW58_RS21815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_RS21820	COG1349	DNA-binding transcription factor activity
EXW58_RS21825	COG1187	pseudouridine synthase activity
EXW58_RS21830	COG2244	polysaccharide biosynthetic process
EXW58_RS21835	COG2081	HI0933 family
EXW58_RS21840	COG2814	Major facilitator Superfamily
EXW58_RS21850	COG3832	glyoxalase III activity
EXW58_RS21870	COG1329	Transcriptional regulator
EXW58_RS21885	COG0314	molybdopterin synthase activity
EXW58_RS21890	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW58_RS21895	COG0303	'Molybdopterin
EXW58_RS21900	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW58_RS21905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_RS21910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW58_RS21930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_RS21940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW58_RS21980	COG0495	leucyl-tRNA aminoacylation
EXW58_RS21985	COG2814	Major facilitator Superfamily
EXW58_RS21990	COG0475	glutathione-regulated potassium exporter activity
EXW58_RS21995	COG0490	domain, Protein
EXW58_RS22000	COG0582	viral genome integration into host DNA
EXW58_RS22010	COG1136	(ABC) transporter
EXW58_RS22025	COG1242	4 iron, 4 sulfur cluster binding
EXW58_RS22030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW58_RS22035	COG1131	(ABC) transporter
EXW58_RS22070	COG2267	carboxylic ester hydrolase activity
EXW58_RS22075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW58_RS22080	COG0671	phosphoesterase, PA-phosphatase related
EXW58_RS22085	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS22095	COG1404	Belongs to the peptidase S8 family
EXW58_RS22100	COG1404	Belongs to the peptidase S8 family
EXW58_RS22110	COG4585	Histidine kinase
EXW58_RS22115	COG0746	molybdenum cofactor guanylyltransferase activity
EXW58_RS22120	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW58_RS22135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW58_RS22140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW58_RS22170	COG5002	protein histidine kinase activity
EXW58_RS22175	COG3852	Histidine kinase
EXW58_RS22180	COG0753	catalase activity
EXW58_RS22185	COG2267	carboxylic ester hydrolase activity
EXW58_RS22190	COG1368	sulfuric ester hydrolase activity
EXW58_RS22195	COG4895	conserved protein (DUF2196)
EXW58_RS22210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW58_RS22215	COG1116	anion transmembrane transporter activity
EXW58_RS22220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_RS22240	COG0494	nUDIX hydrolase
EXW58_RS22270	COG2723	6-phospho-beta-galactosidase activity
EXW58_RS22275	COG2723	6-phospho-beta-galactosidase activity
EXW58_RS22280	COG2190	(PTS) system
EXW58_RS22280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_RS22280	COG1263	PTS System
EXW58_RS22285	COG3711	transcriptional antiterminator
EXW58_RS22295	COG1854	S-ribosylhomocysteine lyase activity
EXW58_RS22305	COG0288	reversible hydration of carbon dioxide
EXW58_RS22310	COG1271	oxidase subunit
EXW58_RS22315	COG1294	oxidase, subunit
EXW58_RS22330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS22355	COG1842	Phage shock protein A
EXW58_RS22380	COG3859	Proton-coupled thiamine transporter YuaJ
EXW58_RS22385	COG5002	protein histidine kinase activity
EXW58_RS22390	COG0745	RESPONSE REGULATOR receiver
EXW58_RS22415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW58_RS22420	COG1597	lipid kinase activity
EXW58_RS22435	COG1136	(ABC) transporter
EXW58_RS22450	COG5002	protein histidine kinase activity
EXW58_RS22460	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS22470	COG0577	efflux transmembrane transporter activity
EXW58_RS22475	COG1136	(ABC) transporter
EXW58_RS22480	COG3708	Transcriptional regulator
EXW58_RS22480	COG2207	Transcriptional regulator
EXW58_RS22485	COG3344	reverse transcriptase
EXW58_RS22495	COG1131	(ABC) transporter
EXW58_RS22500	COG5658	integral membrane protein
EXW58_RS22505	COG0640	Transcriptional regulator
EXW58_RS22510	COG0745	RESPONSE REGULATOR receiver
EXW58_RS22515	COG2205	protein histidine kinase activity
EXW58_RS22520	COG0577	efflux transmembrane transporter activity
EXW58_RS22525	COG0577	efflux transmembrane transporter activity
EXW58_RS22530	COG1136	(ABC) transporter
EXW58_RS22535	COG0577	efflux transmembrane transporter activity
EXW58_RS22545	COG2801	Transposase and inactivated derivatives
EXW58_RS22555	COG2188	Transcriptional regulator
EXW58_RS22575	COG3964	amidohydrolase
EXW58_RS22595	COG4948	Mandelate Racemase Muconate Lactonizing
EXW58_RS22600	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_RS22605	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW58_RS22610	COG0596	Alpha beta hydrolase
EXW58_RS22615	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW58_RS22620	COG1169	isochorismate synthase
EXW58_RS22625	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW58_RS22630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW58_RS22635	COG1278	Cold shock
EXW58_RS22645	COG1051	belongs to the nudix hydrolase family
EXW58_RS22655	COG0058	SHG alpha-glucan phosphorylase activity
EXW58_RS22665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW58_RS22670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW58_RS22675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW58_RS22780	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_RS22815	COG1285	pathogenesis
EXW58_RS22820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW58_RS22830	COG0166	Belongs to the GPI family
EXW58_RS22835	COG2155	Conserved Protein
EXW58_RS22840	COG1098	S1 RNA binding domain
EXW58_RS22845	COG0436	Aminotransferase
EXW58_RS22850	COG1522	sequence-specific DNA binding
EXW58_RS22855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW58_RS22860	COG2267	carboxylic ester hydrolase activity
EXW58_RS22870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW58_RS22890	COG5018	Exonuclease
EXW58_RS22895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW58_RS22920	COG2050	protein possibly involved in aromatic compounds catabolism
EXW58_RS22930	COG1268	BioY protein
EXW58_RS22940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_RS22945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW58_RS22955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW58_RS22960	COG3584	3D domain protein
EXW58_RS22975	COG1252	NADH dehydrogenase
EXW58_RS22980	COG0492	ferredoxin-NADP+ reductase activity
EXW58_RS23000	COG1683	Conserved Protein
EXW58_RS23010	COG0316	Belongs to the HesB IscA family
EXW58_RS23015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW58_RS23020	COG4844	belongs to the
EXW58_RS23025	COG1252	NADH dehydrogenase
EXW58_RS23030	COG2274	protein secretion by the type I secretion system
EXW58_RS23035	COG0390	transport system, permease component
EXW58_RS23040	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW58_RS23060	COG4837	Protein of unknown function (DUF1462)
EXW58_RS23065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW58_RS23075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW58_RS23080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW58_RS23110	COG0647	UMP catabolic process
EXW58_RS23120	COG2445	Protein of unknown function DUF86
EXW58_RS23125	COG1494	fructose-1,6-bisphosphatase
EXW58_RS23145	COG4470	Protein conserved in bacteria
EXW58_RS23155	COG0789	Transcriptional regulator
EXW58_RS23160	COG4377	Putative membrane peptidase family (DUF2324)
EXW58_RS23185	COG0739	heme binding
EXW58_RS23195	COG3377	Domain of unknown function (DUF1805)
EXW58_RS23200	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS23205	COG0719	Fe-S assembly protein
EXW58_RS23210	COG0822	iron-sulfur transferase activity
EXW58_RS23215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW58_RS23220	COG0719	Fe-S assembly protein
EXW58_RS23225	COG0396	ATPase activity
EXW58_RS23230	COG1464	Belongs to the NlpA lipoprotein family
EXW58_RS23235	COG1464	Belongs to the NlpA lipoprotein family
EXW58_RS23240	COG2011	ABC-type metal ion transport system permease component
EXW58_RS23255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_RS23260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW58_RS23265	COG0509	glycine decarboxylation via glycine cleavage system
EXW58_RS23270	COG1393	Belongs to the ArsC family
EXW58_RS23310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS23315	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS23320	COG0183	Belongs to the thiolase family
EXW58_RS23325	COG1024	Enoyl-CoA hydratase
EXW58_RS23325	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_RS23335	COG1686	Belongs to the peptidase S11 family
EXW58_RS23340	COG0506	proline dehydrogenase activity
EXW58_RS23350	COG0011	TIGRFAM Protein of
EXW58_RS23355	COG0840	transmembrane signaling receptor activity
EXW58_RS23370	COG2814	Major facilitator Superfamily
EXW58_RS23375	COG0531	amino acid
EXW58_RS23400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_RS23430	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS23440	COG1376	ErfK ybiS ycfS ynhG family protein
EXW58_RS23445	COG0745	RESPONSE REGULATOR receiver
EXW58_RS23450	COG5002	protein histidine kinase activity
EXW58_RS23465	COG0840	transmembrane signaling receptor activity
EXW58_RS23470	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW58_RS23475	COG3227	Zinc metalloprotease (Elastase)
EXW58_RS23495	COG0586	Pfam SNARE associated Golgi protein
EXW58_RS23500	COG0475	glutathione-regulated potassium exporter activity
EXW58_RS23505	COG0490	domain, Protein
EXW58_RS23510	COG1115	amino acid carrier protein
EXW58_RS23515	COG0783	Belongs to the Dps family
EXW58_RS23525	COG2318	DinB family
EXW58_RS23530	COG1611	Belongs to the LOG family
EXW58_RS23540	COG1528	Iron-storage protein
EXW58_RS23545	COG2311	Membrane
EXW58_RS23550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS23555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS23560	COG1115	amino acid carrier protein
EXW58_RS23565	COG2910	NAD(P)H-binding
EXW58_RS23575	COG0656	L-ascorbic acid biosynthetic process
EXW58_RS23580	COG2814	Major facilitator Superfamily
EXW58_RS23585	COG1733	regulation of RNA biosynthetic process
EXW58_RS23595	COG1252	NADH dehydrogenase
EXW58_RS23655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_RS23680	COG1522	sequence-specific DNA binding
EXW58_RS23685	COG0288	reversible hydration of carbon dioxide
EXW58_RS23690	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW58_RS23695	COG2233	PERMEase
EXW58_RS23715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS23730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW58_RS23735	COG0557	exoribonuclease II activity
EXW58_RS23740	COG1647	Serine aminopeptidase, S33
EXW58_RS23745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW58_RS23750	COG1346	cytolysis
EXW58_RS23775	COG0149	triose-phosphate isomerase activity
EXW58_RS23780	COG0126	phosphoglycerate kinase activity
EXW58_RS23785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW58_RS23800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW58_RS23825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_RS23840	COG2323	membrane
EXW58_RS23850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_RS23855	COG1481	regulation of sporulation
EXW58_RS23860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW58_RS23865	COG1660	Displays ATPase and GTPase activities
EXW58_RS23870	COG1051	belongs to the nudix hydrolase family
EXW58_RS23880	COG0492	ferredoxin-NADP+ reductase activity
EXW58_RS23885	COG0457	Tetratricopeptide repeat
EXW58_RS23890	COG0110	maltose O-acetyltransferase activity
EXW58_RS23895	COG0546	phosphoglycolate phosphatase activity
EXW58_RS23900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW58_RS23905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW58_RS23910	COG1950	PFAM Membrane protein of
EXW58_RS23915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW58_RS23930	COG0789	Transcriptional regulator
EXW58_RS23965	COG0583	DNA-binding transcription factor activity
EXW58_RS23970	COG0789	Transcriptional regulator
EXW58_RS23975	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW58_RS23980	COG0488	(ABC) transporter
EXW58_RS23990	COG1132	(ABC) transporter
EXW58_RS23995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_RS24000	COG0793	Belongs to the peptidase S41A family
EXW58_RS24000	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_RS24005	COG2177	Part of the ABC transporter FtsEX involved in
EXW58_RS24010	COG2884	Cell division ATP-binding protein ftsE
EXW58_RS24045	COG1278	Cold shock
EXW58_RS24050	COG1040	competence protein
EXW58_RS24055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW58_RS24065	COG1733	regulation of RNA biosynthetic process
EXW58_RS24070	COG1307	EDD domain protein, DegV family
EXW58_RS24075	COG1739	Uncharacterized protein family UPF0029
EXW58_RS24080	COG1316	TRANSCRIPTIONal
EXW58_RS24085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW58_RS24090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW58_RS24095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW58_RS24105	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW58_RS24105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW58_RS24130	COG1486	melibiose metabolic process
EXW58_RS24135	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_RS24140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_RS24150	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW58_RS24160	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_RS24170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_RS24175	COG1301	dicarboxylic acid transport
EXW58_RS24190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW58_RS24200	COG1271	oxidase subunit
EXW58_RS24205	COG1294	oxidase, subunit
EXW58_RS24210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW58_RS24220	COG1620	l-lactate permease
EXW58_RS24230	COG2389	metal-binding protein
EXW58_RS24240	COG1368	sulfuric ester hydrolase activity
EXW58_RS24250	COG0791	NLP P60 protein
EXW58_RS24250	COG1388	LysM domain
EXW58_RS24255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_RS24265	COG1215	transferase activity, transferring glycosyl groups
EXW58_RS24270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW58_RS24275	COG1388	LysM domain
EXW58_RS24275	COG3584	3D domain protein
EXW58_RS24295	COG4715	Zinc finger, swim domain protein
EXW58_RS24300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_RS24360	COG0577	efflux transmembrane transporter activity
EXW58_RS24365	COG1136	(ABC) transporter
EXW58_RS24390	COG5002	protein histidine kinase activity
EXW58_RS24390	COG3850	Histidine kinase
EXW58_RS24395	COG0745	RESPONSE REGULATOR receiver
EXW58_RS24400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW58_RS24410	COG1316	TRANSCRIPTIONal
EXW58_RS24415	COG3764	Sortase (surface protein transpeptidase)
EXW58_RS24450	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS24465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW58_RS24470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_RS24475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_RS24480	COG4464	protein tyrosine phosphatase activity
EXW58_RS24490	COG0489	protein tyrosine kinase activity
EXW58_RS24495	COG3944	biosynthesis protein
EXW58_RS24505	COG1132	(ABC) transporter
EXW58_RS24535	COG0367	asparagine synthase
EXW58_RS24540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW58_RS24550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_RS24560	COG1216	Glycosyl transferase, family 2
EXW58_RS24595	COG1215	transferase activity, transferring glycosyl groups
EXW58_RS24615	COG0463	Glycosyl transferase, family 2
EXW58_RS24615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_RS24625	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS24630	COG0438	transferase activity, transferring glycosyl groups
EXW58_RS24635	COG1086	Polysaccharide biosynthesis protein
EXW58_RS24640	COG0489	protein tyrosine kinase activity
EXW58_RS24645	COG3944	biosynthesis protein
EXW58_RS24650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_RS24655	COG1134	teichoic acid transport
EXW58_RS24660	COG1682	transport, permease protein
EXW58_RS24665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_RS24680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_RS24685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW58_RS24695	COG1609	Transcriptional regulator
EXW58_RS24705	COG0739	heme binding
EXW58_RS24720	COG3279	Response regulator of the LytR AlgR family
EXW58_RS24730	COG2385	sporulation resulting in formation of a cellular spore
EXW58_RS24745	COG4836	Membrane
EXW58_RS24750	COG1007	ATP synthesis coupled electron transport
EXW58_RS24755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_RS24760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW58_RS24765	COG0713	ATP synthesis coupled electron transport
EXW58_RS24770	COG0839	Belongs to the complex I subunit 6 family
EXW58_RS24780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW58_RS24785	COG0649	NAD binding
EXW58_RS24790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_RS24795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_RS24800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_RS24805	COG5001	Diguanylate cyclase
EXW58_RS24805	COG3300	MHYT domain
EXW58_RS24820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW58_RS24825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW58_RS24830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW58_RS24835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW58_RS24845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW58_RS24855	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW58_RS24890	COG0698	ribose 5-phosphate isomerase
EXW58_RS24900	COG2190	(PTS) system
EXW58_RS24905	COG2259	Doxx family
EXW58_RS24910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW58_RS24920	COG1971	Probably functions as a manganese efflux pump
EXW58_RS24925	COG0009	L-threonylcarbamoyladenylate synthase
EXW58_RS24940	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW58_RS24945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW58_RS24950	COG1435	thymidine kinase activity
EXW58_RS24960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW58_RS24965	COG1494	fructose-1,6-bisphosphatase
EXW58_RS24985	COG4821	SIS domain
EXW58_RS24990	COG0504	CTP synthase activity
EXW58_RS25005	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS25010	COG1960	acyl-CoA dehydrogenase activity
EXW58_RS25015	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_RS25020	COG0183	Belongs to the thiolase family
EXW58_RS25025	COG0247	lactate metabolic process
EXW58_RS25025	COG2181	nitrate reductase activity
EXW58_RS25030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_RS25035	COG4294	response to UV
EXW58_RS25040	COG5001	Diguanylate cyclase
EXW58_RS25040	COG3300	MHYT domain
EXW58_RS25060	COG3227	Zinc metalloprotease (Elastase)
EXW58_RS25065	COG2197	response regulator
EXW58_RS25070	COG4585	Histidine kinase
EXW58_RS25075	COG0842	Transport permease protein
EXW58_RS25080	COG1131	(ABC) transporter
EXW58_RS25085	COG0024	Methionine aminopeptidase
EXW58_RS25090	COG2234	aminopeptidase activity
EXW58_RS25105	COG4506	Protein conserved in bacteria
EXW58_RS25110	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW58_RS25135	COG2814	Major facilitator Superfamily
EXW58_RS25140	COG0789	Transcriptional regulator
EXW58_RS25145	COG0584	glycerophosphoryl diester phosphodiesterase
EXW58_RS25150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_RS25160	COG1994	Peptidase M50
EXW58_RS25170	COG1078	dGTPase activity
EXW58_RS25175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_RS25180	COG1120	ATPase activity
EXW58_RS25185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS25190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_RS25195	COG4844	belongs to the
EXW58_RS25215	COG0280	phosphate acetyltransferase
EXW58_RS25220	COG3253	May function as heme-dependent peroxidase
EXW58_RS25230	COG3773	Cell wall hydrolase
EXW58_RS25240	COG2363	Small membrane protein
EXW58_RS25250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW58_RS25255	COG2233	PERMEase
EXW58_RS25260	COG0561	phosphatase activity
EXW58_RS25265	COG2814	Major facilitator Superfamily
EXW58_RS25270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW58_RS25275	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_RS25280	COG1131	(ABC) transporter
EXW58_RS25285	COG2755	lipolytic protein G-D-S-L family
EXW58_RS25290	COG1609	Transcriptional regulator
EXW58_RS25300	COG0460	homoserine dehydrogenase
EXW58_RS25305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW58_RS25310	COG2873	o-acetylhomoserine
EXW58_RS25325	COG2197	response regulator
EXW58_RS25330	COG4585	Histidine kinase
EXW58_RS25330	COG2203	Gaf domain
EXW58_RS25335	COG0351	phosphomethylpyrimidine kinase
EXW58_RS25340	COG3706	GGDEF domain
EXW58_RS25345	COG2879	small protein
EXW58_RS25350	COG1966	Carbon starvation protein
EXW58_RS25355	COG3279	Response regulator of the LytR AlgR family
EXW58_RS25360	COG0477	Major facilitator Superfamily
EXW58_RS25385	COG0840	transmembrane signaling receptor activity
EXW58_RS25395	COG1607	acyl-coa hydrolase
EXW58_RS25405	COG1216	Glycosyl transferase, family 2
EXW58_RS25410	COG0488	(ABC) transporter
EXW58_RS25425	COG1309	transcriptional regulator
EXW58_RS25430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW58_RS25435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_RS25435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_RS25455	COG0628	permease
EXW58_RS25465	COG1380	Effector of murein hydrolase LrgA
EXW58_RS25470	COG3279	Response regulator of the LytR AlgR family
EXW58_RS25475	COG3275	phosphorelay sensor kinase activity
EXW58_RS25480	COG2814	Major facilitator Superfamily
EXW58_RS25490	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW58_RS25510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW58_RS25515	COG1272	protein, Hemolysin III
EXW58_RS25540	COG1164	Oligoendopeptidase f
EXW58_RS25555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW58_RS25565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_RS25570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW58_RS25575	COG4853	Protein conserved in bacteria
EXW58_RS25585	COG5002	protein histidine kinase activity
EXW58_RS25590	COG0745	RESPONSE REGULATOR receiver
EXW58_RS25620	COG0305	Participates in initiation and elongation during chromosome replication
EXW58_RS25630	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW58_RS25635	COG4241	membrane
EXW58_RS25645	COG0629	single-stranded DNA binding
EXW58_RS25650	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW58_RS25655	COG0012	GTP binding
EXW58_RS25660	COG4481	Protein conserved in bacteria
EXW58_RS25665	COG0668	transmembrane transport
EXW58_RS25675	COG1475	DNA binding
EXW58_RS25680	COG1192	Involved in chromosome partitioning
EXW58_RS25685	COG1475	DNA binding
EXW58_RS25695	COG0445	tRNA wobble uridine modification
EXW58_RS25700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW58_RS25705	COG1847	R3H domain protein
EXW58_RS25710	COG0706	membrane insertase activity
EXW58_RS25715	COG0594	ribonuclease P activity
EXW58_RS25720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW58_RS25820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW58_RS25860	COG0768	penicillin binding
EXW58_RS25990	COG2801	Transposase and inactivated derivatives
EXW58_RS26030	COG0531	amino acid
EXW58_RS26070	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_RS26150	COG1278	Cold shock
EXW58_RS26245	COG1454	alcohol dehydrogenase
EXW58_RS26245	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_RS26300	COG0302	gtp cyclohydrolase
EXW58_RS26310	COG0720	synthase
EXW58_RS26330	COG4555	ABC transporter
EXW58_RS26340	COG2226	methyltransferase
EXW58_RS26390	COG0697	spore germination
EXW58_RS26395	COG0814	amino acid
EXW58_RS26410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW58_RS26420	COG2707	UPF0756 membrane protein
EXW58_RS26425	COG0596	Alpha beta hydrolase
EXW58_RS26430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_RS26605	COG3655	Transcriptional regulator
EXW58_RS26615	COG4689	acetoacetate decarboxylase
EXW58_RS26620	COG0583	DNA-binding transcription factor activity
EXW58_RS26700	COG3883	PFAM NLP P60 protein
EXW58_RS26700	COG0791	NLP P60 protein
EXW58_RS26825	COG1192	Involved in chromosome partitioning
EXW58_RS26850	COG1278	Cold shock
EXW58_RS26885	COG3620	sequence-specific DNA binding
EXW58_RS26905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW58_RS26920	COG5002	protein histidine kinase activity
EXW58_RS26930	COG0745	RESPONSE REGULATOR receiver
EXW58_RS26950	COG4585	Histidine kinase
EXW58_RS26955	COG2197	response regulator
EXW58_RS26970	COG2801	Transposase and inactivated derivatives
EXW58_RS26980	COG0596	Alpha beta hydrolase
EXW58_RS26985	COG1073	alpha beta
EXW58_RS27080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW58_RS27090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_RS27115	COG2002	toxin-antitoxin pair type II binding
EXW58_RS27210	COG1674	ftsk spoiiie
EXW58_RS27220	COG0741	lytic transglycosylase activity
EXW58_RS27230	COG5002	protein histidine kinase activity
EXW58_RS27235	COG0745	RESPONSE REGULATOR receiver
EXW58_RS27245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_RS27250	COG0577	efflux transmembrane transporter activity
EXW58_RS27255	COG1136	(ABC) transporter
EXW58_RS27290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_RS27315	COG0494	nUDIX hydrolase
EXW58_RS27355	COG1183	phosphatidylcholine synthase activity
EXW58_RS27470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_RS27495	COG2031	fatty acid transporter
EXW58_RS27510	COG2312	Erythromycin esterase
EXW58_RS27535	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_RS27555	COG2070	2-Nitropropane dioxygenase
EXW58_RS27575	COG0582	viral genome integration into host DNA
EXW58_RS27580	COG2801	Transposase and inactivated derivatives
EXW58_RS27650	COG2318	DinB family
EXW58_RS27695	COG1760	l-serine dehydratase
EXW58_RS27700	COG1760	l-serine dehydratase
EXW58_RS27705	COG0814	amino acid
EXW58_RS27715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_RS27740	COG0714	Associated with various cellular activities
EXW58_RS27750	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EXW58_RS27780	COG0737	Belongs to the 5'-nucleotidase family
EXW58_RS27785	COG4974	Belongs to the 'phage' integrase family
EXW58_RS27875	COG1923	regulation of RNA biosynthetic process
EXW58_RS27900	COG0443	Heat shock 70 kDa protein
EXW58_RS27905	COG0457	Tetratricopeptide repeat
EXW58_RS28105	COG1674	ftsk spoiiie
EXW58_RS28110	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_RS28130	COG4842	Belongs to the WXG100 family
EXW58_RS28210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW58_RS28210	COG2755	lipolytic protein G-D-S-L family
EXW58_RS28245	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_RS28245	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW58_RS28255	COG0582	viral genome integration into host DNA
EXW58_RS28315	COG2002	toxin-antitoxin pair type II binding
EXW58_RS28335	COG3227	Zinc metalloprotease (Elastase)
EXW58_RS28345	COG0577	efflux transmembrane transporter activity
EXW58_RS28350	COG1136	(ABC) transporter
EXW58_RS28390	COG2002	toxin-antitoxin pair type II binding
EXW58_RS28450	COG2186	Transcriptional regulator
EXW58_RS28475	COG0662	Cupin 2, conserved barrel domain protein
EXW58_RS28765	COG3584	3D domain protein
EXW58_RS28765	COG1388	LysM domain
EXW58_RS28805	COG1671	Belongs to the UPF0178 family