locus-tag	class	description
EXW60_RS00005	COG1876	peptidase activity
EXW60_RS00050	COG0741	lytic transglycosylase activity
EXW60_RS00120	COG1522	sequence-specific DNA binding
EXW60_RS00125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW60_RS00130	COG0657	acetylesterase activity
EXW60_RS00140	COG2814	Major facilitator Superfamily
EXW60_RS00145	COG1309	transcriptional regulator
EXW60_RS00175	COG0814	amino acid
EXW60_RS00200	COG1151	hydroxylamine reductase activity
EXW60_RS00235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS00245	COG2072	flavoprotein involved in K transport
EXW60_RS00290	COG1695	Transcriptional regulator
EXW60_RS00295	COG0604	alcohol dehydrogenase
EXW60_RS00300	COG1113	amino acid transport
EXW60_RS00310	COG2814	Major facilitator Superfamily
EXW60_RS00320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW60_RS00325	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS00335	COG0534	Mate efflux family protein
EXW60_RS00340	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS00345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW60_RS00360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW60_RS00365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW60_RS00385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS00390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS00395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS00400	COG3739	integral membrane protein
EXW60_RS00420	COG0583	DNA-binding transcription factor activity
EXW60_RS00445	COG1193	negative regulation of DNA recombination
EXW60_RS00465	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW60_RS00470	COG1164	Oligoendopeptidase f
EXW60_RS00495	COG3781	membrane
EXW60_RS00510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS00570	COG0640	Transcriptional regulator
EXW60_RS00575	COG0604	alcohol dehydrogenase
EXW60_RS00580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW60_RS00585	COG0457	Tetratricopeptide repeat
EXW60_RS00595	COG2808	Putative FMN-binding domain
EXW60_RS00600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW60_RS00610	COG0277	FAD linked oxidase domain protein
EXW60_RS00630	COG1285	pathogenesis
EXW60_RS00640	COG2514	catechol 2,3-dioxygenase activity
EXW60_RS00645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS00650	COG1126	abc transporter atp-binding protein
EXW60_RS00655	COG0765	amino acid transport
EXW60_RS00660	COG2720	vancomycin resistance protein
EXW60_RS00685	COG1278	Cold shock
EXW60_RS00695	COG0716	FMN binding
EXW60_RS00705	COG0494	nUDIX hydrolase
EXW60_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS00735	COG0165	Argininosuccinate lyase
EXW60_RS00750	COG4145	pantothenate transmembrane transporter activity
EXW60_RS00760	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS00765	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS00775	COG1657	PFAM Prenyltransferase squalene oxidase
EXW60_RS00780	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW60_RS00785	COG2962	Rard protein
EXW60_RS00790	COG3326	Membrane
EXW60_RS00795	COG0531	amino acid
EXW60_RS00830	COG2226	methyltransferase
EXW60_RS00835	COG4166	transmembrane transport
EXW60_RS00840	COG4166	transmembrane transport
EXW60_RS00845	COG4166	transmembrane transport
EXW60_RS00855	COG1131	(ABC) transporter
EXW60_RS00875	COG0673	inositol 2-dehydrogenase activity
EXW60_RS00880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW60_RS00885	COG0187	DNA topoisomerase II activity
EXW60_RS00890	COG1832	CoA-binding protein
EXW60_RS00895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW60_RS00900	COG0745	RESPONSE REGULATOR receiver
EXW60_RS00910	COG1328	CTP reductase activity
EXW60_RS00910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW60_RS00920	COG4841	protein insertion into membrane
EXW60_RS00925	COG0824	Thioesterase
EXW60_RS00950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS00970	COG2274	protein secretion by the type I secretion system
EXW60_RS00975	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW60_RS01005	COG2211	Major facilitator Superfamily
EXW60_RS01015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW60_RS01030	COG0183	Belongs to the thiolase family
EXW60_RS01035	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS01040	COG1268	BioY protein
EXW60_RS01045	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS01050	COG1396	sequence-specific DNA binding
EXW60_RS01090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS01100	COG5002	protein histidine kinase activity
EXW60_RS01110	COG0400	carboxylic ester hydrolase activity
EXW60_RS01115	COG0346	lactoylglutathione lyase activity
EXW60_RS01120	COG0069	glutamate synthase activity
EXW60_RS01125	COG1902	pentaerythritol trinitrate reductase activity
EXW60_RS01135	COG1329	Transcriptional regulator
EXW60_RS01140	COG0010	Belongs to the arginase family
EXW60_RS01150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW60_RS01155	COG2986	histidine ammonia-lyase
EXW60_RS01165	COG2226	methyltransferase
EXW60_RS01190	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW60_RS01195	COG0785	Cytochrome C biogenesis protein
EXW60_RS01205	COG1473	amidohydrolase
EXW60_RS01210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW60_RS01215	COG1131	(ABC) transporter
EXW60_RS01225	COG0583	DNA-binding transcription factor activity
EXW60_RS01235	COG1346	cytolysis
EXW60_RS01250	COG0730	response to heat
EXW60_RS01260	COG3409	Peptidoglycan-binding domain 1 protein
EXW60_RS01260	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS01280	COG1132	(ABC) transporter
EXW60_RS01285	COG1132	(ABC) transporter
EXW60_RS01290	COG3763	UPF0154 protein
EXW60_RS01310	COG3639	organic phosphonate transmembrane transporter activity
EXW60_RS01320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS01325	COG0737	Belongs to the 5'-nucleotidase family
EXW60_RS01335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW60_RS01340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW60_RS01355	COG1695	Transcriptional regulator
EXW60_RS01360	COG0174	glutamine synthetase
EXW60_RS01365	COG0789	Transcriptional regulator
EXW60_RS01370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW60_RS01375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW60_RS01380	COG2860	membrane
EXW60_RS01390	COG0464	growth
EXW60_RS01410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW60_RS01420	COG3584	3D domain protein
EXW60_RS01420	COG1388	LysM domain
EXW60_RS01425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW60_RS01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW60_RS01425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW60_RS01430	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW60_RS01435	COG1349	DNA-binding transcription factor activity
EXW60_RS01440	COG1979	alcohol dehydrogenase
EXW60_RS01445	COG2322	membrane
EXW60_RS01455	COG1113	amino acid transport
EXW60_RS01465	COG1473	amidohydrolase
EXW60_RS01470	COG1408	metallophosphoesterase
EXW60_RS01475	COG2116	formate transmembrane transporter activity
EXW60_RS01490	COG2217	Heavy metal translocating P-type atpase
EXW60_RS01495	COG2608	mercury ion transmembrane transporter activity
EXW60_RS01500	COG1937	Protein conserved in bacteria
EXW60_RS01520	COG2819	hydrolase of the alpha beta superfamily
EXW60_RS01525	COG1120	ATPase activity
EXW60_RS01530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS01535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS01540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS01545	COG0708	Exodeoxyribonuclease III
EXW60_RS01550	COG2169	Transcriptional regulator
EXW60_RS01555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW60_RS01560	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW60_RS01565	COG2706	6-phosphogluconolactonase activity
EXW60_RS01570	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW60_RS01575	COG2364	Membrane
EXW60_RS01585	COG0346	lactoylglutathione lyase activity
EXW60_RS01630	COG1346	cytolysis
EXW60_RS01640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS01645	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW60_RS01645	COG0596	Alpha beta hydrolase
EXW60_RS01650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW60_RS01660	COG2188	Transcriptional regulator
EXW60_RS01665	COG2723	6-phospho-beta-galactosidase activity
EXW60_RS01675	COG3773	Cell wall hydrolase
EXW60_RS01685	COG1368	sulfuric ester hydrolase activity
EXW60_RS01690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW60_RS01700	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW60_RS01705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW60_RS01710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW60_RS01720	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW60_RS01725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW60_RS01730	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW60_RS01735	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW60_RS01735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW60_RS01745	COG2359	stage V sporulation protein S
EXW60_RS01750	COG1692	metallophosphoesterase
EXW60_RS01755	COG1418	mRNA catabolic process
EXW60_RS01760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW60_RS01765	COG1058	Belongs to the CinA family
EXW60_RS01765	COG1546	Belongs to the CinA family
EXW60_RS01770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW60_RS01775	COG1426	Protein conserved in bacteria
EXW60_RS01790	COG0300	oxidoreductase activity
EXW60_RS01795	COG0612	Peptidase, M16
EXW60_RS01800	COG0612	Peptidase, M16
EXW60_RS01805	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW60_RS01810	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW60_RS01815	COG3845	ABC transporter
EXW60_RS01820	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW60_RS01825	COG2188	Transcriptional regulator
EXW60_RS01830	COG1674	ftsk spoiiie
EXW60_RS01840	COG0740	serine-type endopeptidase activity
EXW60_RS01845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW60_RS01855	COG0527	aspartate kinase activity
EXW60_RS01860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW60_RS01885	COG4824	toxin secretion phage lysis holin
EXW60_RS02005	COG1278	Cold shock
EXW60_RS02015	COG0582	viral genome integration into host DNA
EXW60_RS02070	COG0305	Participates in initiation and elongation during chromosome replication
EXW60_RS02105	COG1396	sequence-specific DNA binding
EXW60_RS02140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW60_RS02145	COG1873	PFAM PRC-barrel domain
EXW60_RS02150	COG0612	Peptidase, M16
EXW60_RS02155	COG0726	polysaccharide deacetylase
EXW60_RS02160	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW60_RS02170	COG0196	riboflavin kinase activity
EXW60_RS02180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW60_RS02185	COG1550	Protein conserved in bacteria
EXW60_RS02190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW60_RS02195	COG1358	cellular component organization or biogenesis
EXW60_RS02200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW60_RS02205	COG0195	Participates in both transcription termination and antitermination
EXW60_RS02210	COG0779	Required for maturation of 30S ribosomal subunits
EXW60_RS02220	COG0442	prolyl-tRNA aminoacylation
EXW60_RS02225	COG0750	zinc metalloprotease
EXW60_RS02235	COG4589	Belongs to the CDS family
EXW60_RS02245	COG0233	cytoplasmic translational termination
EXW60_RS02250	COG0528	UMP kinase activity
EXW60_RS02255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW60_RS02260	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW60_RS02265	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW60_RS02270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW60_RS02275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW60_RS02280	COG4974	Belongs to the 'phage' integrase family
EXW60_RS02285	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW60_RS02290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW60_RS02295	COG0758	DNA mediated transformation
EXW60_RS02300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW60_RS02305	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW60_RS02310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW60_RS02325	COG0335	large ribosomal subunit rRNA binding
EXW60_RS02330	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW60_RS02335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW60_RS02340	COG1837	Belongs to the UPF0109 family
EXW60_RS02350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW60_RS02355	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW60_RS02360	COG0552	protein localization to endoplasmic reticulum
EXW60_RS02365	COG1196	nuclear chromosome segregation
EXW60_RS02370	COG0571	ribonuclease III activity
EXW60_RS02375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW60_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS02385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW60_RS02390	COG0416	fatty acid biosynthetic process
EXW60_RS02395	COG1349	DNA-binding transcription factor activity
EXW60_RS02395	COG2050	protein possibly involved in aromatic compounds catabolism
EXW60_RS02400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW60_RS02405	COG1461	Dihydroxyacetone kinase
EXW60_RS02410	COG1302	Protein conserved in bacteria
EXW60_RS02425	COG1564	THIamine pyrophosphokinase
EXW60_RS02430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW60_RS02440	COG2815	serine threonine protein kinase
EXW60_RS02440	COG0515	serine threonine protein kinase
EXW60_RS02445	COG0631	protein serine/threonine phosphatase activity
EXW60_RS02450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW60_RS02455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW60_RS02455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW60_RS02460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW60_RS02465	COG0242	peptide deformylase activity
EXW60_RS02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW60_RS02475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW60_RS02480	COG1758	RNA polymerase activity
EXW60_RS02495	COG1561	YicC-like family, N-terminal region
EXW60_RS02500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW60_RS02515	COG0006	proline dipeptidase activity
EXW60_RS02535	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW60_RS02555	COG0167	dihydroorotate dehydrogenase activity
EXW60_RS02560	COG0543	2 iron, 2 sulfur cluster binding
EXW60_RS02565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW60_RS02575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW60_RS02580	COG0540	Belongs to the ATCase OTCase family
EXW60_RS02590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW60_RS02595	COG0564	pseudouridine synthase activity
EXW60_RS02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW60_RS02610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW60_RS02615	COG3599	regulation of cell shape
EXW60_RS02620	COG2302	S4 RNA-binding domain
EXW60_RS02625	COG0762	integral membrane protein
EXW60_RS02630	COG1799	cell septum assembly
EXW60_RS02635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW60_RS02645	COG1873	PFAM PRC-barrel domain
EXW60_RS02650	COG1191	sigma factor activity
EXW60_RS02655	COG1191	sigma factor activity
EXW60_RS02665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW60_RS02670	COG0849	cell division
EXW60_RS02675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW60_RS02690	COG0772	Belongs to the SEDS family
EXW60_RS02695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW60_RS02700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW60_RS02705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW60_RS02710	COG0768	penicillin binding
EXW60_RS02715	COG0768	penicillin binding
EXW60_RS02725	COG0275	rRNA processing
EXW60_RS02730	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW60_RS02735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW60_RS02740	COG0454	-acetyltransferase
EXW60_RS02750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW60_RS02755	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW60_RS02760	COG1323	Belongs to the UPF0348 family
EXW60_RS02765	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW60_RS02770	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW60_RS02775	COG3314	Sporulation integral membrane protein YlbJ
EXW60_RS02785	COG0742	ribosomal rna small subunit methyltransferase
EXW60_RS02795	COG4471	UPF0298 protein
EXW60_RS02800	COG3679	Belongs to the UPF0342 family
EXW60_RS02805	COG0406	alpha-ribazole phosphatase activity
EXW60_RS02820	COG2340	Cysteine-rich secretory protein family
EXW60_RS02830	COG3336	cytochrome c oxidase
EXW60_RS02855	COG0109	protoheme IX farnesyltransferase activity
EXW60_RS02860	COG1612	heme a metabolic process
EXW60_RS02865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW60_RS02870	COG0772	Belongs to the SEDS family
EXW60_RS02875	COG4838	Belongs to the UPF0358 family
EXW60_RS02880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW60_RS02885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW60_RS02895	COG4896	Protein conserved in bacteria
EXW60_RS02910	COG1217	gtp-binding protein TYPA
EXW60_RS02920	COG0483	inositol monophosphate 1-phosphatase activity
EXW60_RS02930	COG4493	Belongs to the UPF0637 family
EXW60_RS02935	COG4476	Belongs to the UPF0223 family
EXW60_RS02940	COG1982	Orn Lys Arg decarboxylase major
EXW60_RS02985	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW60_RS02990	COG0022	dehydrogenase e1 component
EXW60_RS02995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW60_RS03010	COG0561	phosphatase activity
EXW60_RS03015	COG5503	Protein of unknown function (DUF1447)
EXW60_RS03020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW60_RS03025	COG0569	domain protein
EXW60_RS03035	COG1473	amidohydrolase
EXW60_RS03040	COG2171	N-acyltransferase activity
EXW60_RS03045	COG0583	DNA-binding transcription factor activity
EXW60_RS03050	COG0517	IMP dehydrogenase activity
EXW60_RS03060	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW60_RS03070	COG4703	Protein of unknown function (DUF1797)
EXW60_RS03085	COG2200	EAL domain
EXW60_RS03090	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS03095	COG1408	metallophosphoesterase
EXW60_RS03140	COG2814	Major facilitator Superfamily
EXW60_RS03150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW60_RS03160	COG3209	COG3209 Rhs family protein
EXW60_RS03170	COG2205	protein histidine kinase activity
EXW60_RS03180	COG0436	Aminotransferase
EXW60_RS03185	COG1609	Transcriptional regulator
EXW60_RS03190	COG3833	ABC-type maltose transport systems, permease component
EXW60_RS03195	COG1175	transmembrane transport
EXW60_RS03200	COG2182	Extracellular solute-binding protein
EXW60_RS03210	COG0366	Alpha amylase catalytic
EXW60_RS03215	COG3842	ATPase activity
EXW60_RS03255	COG0183	Belongs to the thiolase family
EXW60_RS03285	COG1695	Transcriptional regulator
EXW60_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS03300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW60_RS03305	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW60_RS03310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW60_RS03315	COG0436	Aminotransferase
EXW60_RS03320	COG1850	ribulose-bisphosphate carboxylase activity
EXW60_RS03325	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW60_RS03350	COG2084	Dehydrogenase
EXW60_RS03360	COG2199	diguanylate cyclase activity
EXW60_RS03365	COG0778	Nitroreductase
EXW60_RS03390	COG1263	PTS System
EXW60_RS03390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW60_RS03390	COG2190	(PTS) system
EXW60_RS03395	COG3711	transcriptional antiterminator
EXW60_RS03405	COG2188	Transcriptional regulator
EXW60_RS03410	COG0363	glucosamine-6-phosphate deaminase activity
EXW60_RS03415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW60_RS03425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW60_RS03430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW60_RS03440	COG1547	Domain of unknown function (DUF309)
EXW60_RS03450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW60_RS03455	COG4086	secreted protein
EXW60_RS03460	COG0561	phosphatase activity
EXW60_RS03465	COG0697	spore germination
EXW60_RS03480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW60_RS03520	COG1686	Belongs to the peptidase S11 family
EXW60_RS03525	COG1725	Transcriptional regulator
EXW60_RS03530	COG1131	(ABC) transporter
EXW60_RS03555	COG1846	Transcriptional regulator
EXW60_RS03570	COG0598	Magnesium transport protein CorA
EXW60_RS03585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW60_RS03595	COG4974	Belongs to the 'phage' integrase family
EXW60_RS03605	COG0735	belongs to the Fur family
EXW60_RS03610	COG1300	Membrane
EXW60_RS03630	COG0667	Aldo Keto reductase
EXW60_RS03635	COG0656	L-ascorbic acid biosynthetic process
EXW60_RS03640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW60_RS03640	COG0456	acetyltransferase
EXW60_RS03650	COG1525	nuclease
EXW60_RS03650	COG0737	Belongs to the 5'-nucleotidase family
EXW60_RS03650	COG4085	toxin activity
EXW60_RS03655	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW60_RS03665	COG0596	Alpha beta hydrolase
EXW60_RS03670	COG2056	Na+-H+ antiporter family
EXW60_RS03675	COG1609	Transcriptional regulator
EXW60_RS03680	COG0456	acetyltransferase
EXW60_RS03685	COG1073	alpha beta
EXW60_RS03700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW60_RS03700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW60_RS03705	COG0307	riboflavin synthase, alpha
EXW60_RS03710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW60_RS03710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW60_RS03725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW60_RS03730	COG4106	trans-aconitate 2-methyltransferase activity
EXW60_RS03735	COG2226	methyltransferase
EXW60_RS03735	COG1073	alpha beta
EXW60_RS03740	COG0156	8-amino-7-oxononanoate synthase activity
EXW60_RS03750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW60_RS03760	COG1757	Na H antiporter
EXW60_RS03765	COG0737	Belongs to the 5'-nucleotidase family
EXW60_RS03775	COG1522	sequence-specific DNA binding
EXW60_RS03805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW60_RS03810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW60_RS03820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW60_RS03830	COG0300	oxidoreductase activity
EXW60_RS03835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS03840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW60_RS03845	COG1760	l-serine dehydratase
EXW60_RS03850	COG1760	l-serine dehydratase
EXW60_RS03860	COG1234	tRNA 3'-trailer cleavage
EXW60_RS03875	COG1285	pathogenesis
EXW60_RS03890	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW60_RS03895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS03910	COG1376	ErfK ybiS ycfS ynhG family protein
EXW60_RS03915	COG4129	membrane
EXW60_RS03920	COG1126	abc transporter atp-binding protein
EXW60_RS03925	COG0765	amino acid transport
EXW60_RS03930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS03940	COG2816	NAD+ diphosphatase activity
EXW60_RS03945	COG2323	membrane
EXW60_RS03950	COG0772	Belongs to the SEDS family
EXW60_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW60_RS03960	COG0022	dehydrogenase e1 component
EXW60_RS03965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW60_RS03970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW60_RS03975	COG3426	butyrate kinase activity
EXW60_RS03985	COG0280	phosphate acetyltransferase
EXW60_RS03990	COG3829	transcription factor binding
EXW60_RS03990	COG3290	protein histidine kinase activity
EXW60_RS04000	COG0584	glycerophosphoryl diester phosphodiesterase
EXW60_RS04005	COG3093	addiction module antidote protein HigA
EXW60_RS04045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW60_RS04090	COG0745	RESPONSE REGULATOR receiver
EXW60_RS04095	COG0750	zinc metalloprotease
EXW60_RS04100	COG0497	DNA recombination
EXW60_RS04105	COG1438	arginine binding
EXW60_RS04110	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW60_RS04115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW60_RS04120	COG0142	geranyltranstransferase activity
EXW60_RS04125	COG1722	exodeoxyribonuclease VII activity
EXW60_RS04130	COG1570	exodeoxyribonuclease VII activity
EXW60_RS04135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW60_RS04140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW60_RS04145	COG1302	Protein conserved in bacteria
EXW60_RS04150	COG0439	Biotin carboxylase
EXW60_RS04155	COG0511	ligase activity, forming carbon-carbon bonds
EXW60_RS04200	COG3854	ATPases associated with a variety of cellular activities
EXW60_RS04220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW60_RS04225	COG0006	proline dipeptidase activity
EXW60_RS04230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW60_RS04240	COG3872	metal-dependent enzyme
EXW60_RS04250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW60_RS04255	COG1321	iron dependent repressor
EXW60_RS04285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS04295	COG1609	Transcriptional regulator
EXW60_RS04305	COG2076	Multidrug Resistance protein
EXW60_RS04310	COG2076	Multidrug Resistance protein
EXW60_RS04340	COG1131	(ABC) transporter
EXW60_RS04345	COG1725	Transcriptional regulator
EXW60_RS04360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW60_RS04365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW60_RS04370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW60_RS04375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW60_RS04400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW60_RS04425	COG4970	Tfp pilus assembly protein FimT
EXW60_RS04435	COG1459	type II secretion system
EXW60_RS04440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW60_RS04495	COG1410	methionine synthase
EXW60_RS04495	COG0646	methionine synthase
EXW60_RS04500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW60_RS04500	COG0646	methionine synthase
EXW60_RS04505	COG0626	cystathionine gamma-synthase activity
EXW60_RS04510	COG0626	cystathionine gamma-synthase activity
EXW60_RS04525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS04535	COG1940	carbohydrate kinase activity
EXW60_RS04540	COG4483	Protein conserved in bacteria
EXW60_RS04545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW60_RS04550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW60_RS04555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW60_RS04560	COG0704	Plays a role in the regulation of phosphate uptake
EXW60_RS04570	COG0581	inorganic phosphate transmembrane transporter activity
EXW60_RS04575	COG0573	inorganic phosphate transmembrane transporter activity
EXW60_RS04580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW60_RS04585	COG0768	penicillin binding
EXW60_RS04590	COG0477	Major facilitator Superfamily
EXW60_RS04595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW60_RS04615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW60_RS04620	COG0735	belongs to the Fur family
EXW60_RS04625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW60_RS04630	COG1121	(ABC) transporter
EXW60_RS04635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS04645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW60_RS04660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW60_RS04665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW60_RS04670	COG2384	SAM-dependent methyltransferase
EXW60_RS04680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW60_RS04685	COG0358	DNA primase activity
EXW60_RS04695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW60_RS04700	COG0517	IMP dehydrogenase activity
EXW60_RS04705	COG1381	Involved in DNA repair and RecF pathway recombination
EXW60_RS04715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW60_RS04720	COG0295	cytidine deaminase activity
EXW60_RS04725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW60_RS04730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW60_RS04735	COG1480	7TM receptor with intracellular HD hydrolase
EXW60_RS04740	COG1702	phosphate starvation-inducible protein PhoH
EXW60_RS04755	COG1610	YqeY-like protein
EXW60_RS04760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW60_RS04765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW60_RS04770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW60_RS04780	COG0484	heat shock protein binding
EXW60_RS04785	COG0443	Heat shock 70 kDa protein
EXW60_RS04795	COG1420	regulation of RNA biosynthetic process
EXW60_RS04800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW60_RS04805	COG1733	regulation of RNA biosynthetic process
EXW60_RS04810	COG0481	GTPase activity
EXW60_RS04820	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW60_RS04825	COG0268	Binds directly to 16S ribosomal RNA
EXW60_RS04830	COG1466	dna polymerase III delta subunit
EXW60_RS04840	COG0658	competence protein
EXW60_RS04840	COG2333	competence protein COMEC
EXW60_RS04845	COG2131	deaminase
EXW60_RS04850	COG1555	photosystem II stabilization
EXW60_RS04850	COG1596	polysaccharide export
EXW60_RS04855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW60_RS04860	COG2226	methyltransferase
EXW60_RS04865	COG0799	negative regulation of ribosome biogenesis
EXW60_RS04870	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW60_RS04875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW60_RS04880	COG1534	Rna-binding protein
EXW60_RS04885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW60_RS04890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW60_RS04895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW60_RS04905	COG0688	phosphatidylethanolamine metabolic process
EXW60_RS04915	COG1595	DNA-templated transcription, initiation
EXW60_RS04920	COG2357	RelA SpoT domain protein
EXW60_RS04930	COG1785	Belongs to the alkaline phosphatase family
EXW60_RS04940	COG2267	carboxylic ester hydrolase activity
EXW60_RS04975	COG1404	Belongs to the peptidase S8 family
EXW60_RS04980	COG3186	Phenylalanine-4-hydroxylase
EXW60_RS04985	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW60_RS04990	COG2514	catechol 2,3-dioxygenase activity
EXW60_RS04995	COG2259	Doxx family
EXW60_RS05035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS05045	COG1454	alcohol dehydrogenase
EXW60_RS05045	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS05050	COG0626	cystathionine gamma-synthase activity
EXW60_RS05055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW60_RS05060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW60_RS05065	COG2226	methyltransferase
EXW60_RS05080	COG0768	penicillin binding
EXW60_RS05085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW60_RS05090	COG0572	uridine kinase
EXW60_RS05095	COG0826	peptidase U32
EXW60_RS05100	COG0826	peptidase U32
EXW60_RS05105	COG4122	O-methyltransferase activity
EXW60_RS05110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW60_RS05120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW60_RS05125	COG4472	Bacterial protein of unknown function (DUF965)
EXW60_RS05130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW60_RS05140	COG0628	permease
EXW60_RS05160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW60_RS05170	COG0482	sulfurtransferase activity
EXW60_RS05175	COG1104	cysteine desulfurase activity
EXW60_RS05180	COG1959	2 iron, 2 sulfur cluster binding
EXW60_RS05185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW60_RS05195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW60_RS05200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW60_RS05215	COG1490	D-aminoacyl-tRNA deacylase activity
EXW60_RS05220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW60_RS05225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW60_RS05230	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW60_RS05230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW60_RS05235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW60_RS05240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW60_RS05240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW60_RS05250	COG2244	polysaccharide biosynthetic process
EXW60_RS05255	COG2323	membrane
EXW60_RS05265	COG1862	Preprotein translocase
EXW60_RS05270	COG0343	queuine tRNA-ribosyltransferase activity
EXW60_RS05285	COG2255	four-way junction helicase activity
EXW60_RS05290	COG0632	four-way junction helicase activity
EXW60_RS05295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW60_RS05320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW60_RS05325	COG0157	Belongs to the NadC ModD family
EXW60_RS05330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW60_RS05335	COG1104	cysteine desulfurase activity
EXW60_RS05340	COG1827	regulation of RNA biosynthetic process
EXW60_RS05345	COG2258	MOSC domain
EXW60_RS05350	COG0077	Prephenate dehydratase
EXW60_RS05355	COG0577	efflux transmembrane transporter activity
EXW60_RS05360	COG0577	efflux transmembrane transporter activity
EXW60_RS05365	COG1136	(ABC) transporter
EXW60_RS05370	COG5002	protein histidine kinase activity
EXW60_RS05375	COG0745	RESPONSE REGULATOR receiver
EXW60_RS05380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW60_RS05385	COG3290	protein histidine kinase activity
EXW60_RS05395	COG2868	ribosomal protein
EXW60_RS05405	COG1530	ribonuclease E activity
EXW60_RS05410	COG1994	Peptidase M50
EXW60_RS05415	COG0739	heme binding
EXW60_RS05420	COG2894	cell division
EXW60_RS05425	COG0850	regulation of cytokinetic process
EXW60_RS05440	COG1077	Cell shape determining protein MreB Mrl
EXW60_RS05445	COG2003	Belongs to the UPF0758 family
EXW60_RS05450	COG0424	maF-like protein
EXW60_RS05460	COG0285	dihydrofolate synthase activity
EXW60_RS05475	COG1388	LysM domain
EXW60_RS05480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW60_RS05485	COG0113	porphobilinogen synthase activity
EXW60_RS05490	COG1587	Uroporphyrinogen-III synthase
EXW60_RS05495	COG0181	hydroxymethylbilane synthase activity
EXW60_RS05500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW60_RS05505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW60_RS05510	COG1846	Transcriptional regulator
EXW60_RS05515	COG1764	response to oxidative stress
EXW60_RS05520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW60_RS05530	COG1067	ATP-dependent peptidase activity
EXW60_RS05530	COG0470	DNA polymerase III
EXW60_RS05540	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW60_RS05570	COG0622	Phosphoesterase
EXW60_RS05580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW60_RS05585	COG5401	PFAM Sporulation and spore germination
EXW60_RS05595	COG0477	Major facilitator Superfamily
EXW60_RS05605	COG1309	transcriptional regulator
EXW60_RS05615	COG2197	response regulator
EXW60_RS05620	COG2233	PERMEase
EXW60_RS05625	COG0402	S-adenosylhomocysteine deaminase activity
EXW60_RS05630	COG1983	PspC domain protein
EXW60_RS05635	COG1396	sequence-specific DNA binding
EXW60_RS05640	COG0697	spore germination
EXW60_RS05650	COG1959	2 iron, 2 sulfur cluster binding
EXW60_RS05655	COG1668	transmembrane transport
EXW60_RS05660	COG4152	abc transporter atp-binding protein
EXW60_RS05665	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW60_RS05670	COG1360	Flagellar Motor Protein
EXW60_RS05675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW60_RS05680	COG1876	peptidase activity
EXW60_RS05685	COG0824	Thioesterase
EXW60_RS05690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW60_RS05695	COG1053	succinate dehydrogenase
EXW60_RS05700	COG2009	succinate dehydrogenase
EXW60_RS05705	COG1719	4-vinyl reductase, 4VR
EXW60_RS05710	COG0322	excinuclease ABC activity
EXW60_RS05715	COG3118	belongs to the thioredoxin family
EXW60_RS05720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW60_RS05725	COG2086	electron transfer activity
EXW60_RS05730	COG1024	Enoyl-CoA hydratase
EXW60_RS05735	COG1309	transcriptional regulator
EXW60_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS05765	COG2318	DinB family
EXW60_RS05795	COG1131	(ABC) transporter
EXW60_RS05800	COG2205	protein histidine kinase activity
EXW60_RS05805	COG0745	RESPONSE REGULATOR receiver
EXW60_RS05815	COG4895	conserved protein (DUF2196)
EXW60_RS05820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW60_RS05830	COG2329	Antibiotic biosynthesis monooxygenase
EXW60_RS05835	COG4509	Sortase family
EXW60_RS05840	COG1120	ATPase activity
EXW60_RS05855	COG5386	Cell surface protein
EXW60_RS05865	COG5386	Cell surface protein
EXW60_RS05870	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS05880	COG1193	negative regulation of DNA recombination
EXW60_RS05885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW60_RS05885	COG1796	DNA polymerase
EXW60_RS05890	COG1286	toxin biosynthetic process
EXW60_RS05895	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW60_RS05900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW60_RS05935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW60_RS05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW60_RS05950	COG1418	mRNA catabolic process
EXW60_RS05980	COG2814	Major facilitator Superfamily
EXW60_RS05985	COG1566	PFAM secretion protein HlyD family protein
EXW60_RS05990	COG1309	transcriptional regulator
EXW60_RS05995	COG1363	Peptidase, m42
EXW60_RS06005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW60_RS06020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW60_RS06030	COG1484	DNA-dependent DNA replication
EXW60_RS06035	COG3611	Membrane attachment protein
EXW60_RS06040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW60_RS06045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW60_RS06050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW60_RS06055	COG0237	dephospho-CoA kinase activity
EXW60_RS06060	COG1971	Probably functions as a manganese efflux pump
EXW60_RS06070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW60_RS06070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW60_RS06075	COG5002	protein histidine kinase activity
EXW60_RS06080	COG0745	RESPONSE REGULATOR receiver
EXW60_RS06095	COG0039	L-malate dehydrogenase activity
EXW60_RS06100	COG0538	isocitrate dehydrogenase activity
EXW60_RS06105	COG0372	Belongs to the citrate synthase family
EXW60_RS06115	COG0628	permease
EXW60_RS06120	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW60_RS06130	COG0205	6-phosphofructokinase activity
EXW60_RS06140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW60_RS06145	COG1725	Transcriptional regulator
EXW60_RS06150	COG0281	malic enzyme
EXW60_RS06155	COG0587	DNA-directed DNA polymerase activity
EXW60_RS06170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW60_RS06185	COG4109	DRTGG domain
EXW60_RS06195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW60_RS06200	COG0006	proline dipeptidase activity
EXW60_RS06225	COG0662	Cupin 2, conserved barrel domain protein
EXW60_RS06235	COG1476	TRANSCRIPTIONal
EXW60_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS06255	COG0589	response to stress
EXW60_RS06270	COG0165	Argininosuccinate lyase
EXW60_RS06275	COG0137	argininosuccinate synthase activity
EXW60_RS06290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS06310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW60_RS06315	COG0827	DNA restriction-modification system
EXW60_RS06320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW60_RS06325	COG3874	Sporulation protein YtfJ
EXW60_RS06340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW60_RS06350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW60_RS06365	COG1104	cysteine desulfurase activity
EXW60_RS06370	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW60_RS06380	COG1309	transcriptional regulator
EXW60_RS06385	COG1956	GAF domain-containing protein
EXW60_RS06390	COG0626	cystathionine gamma-synthase activity
EXW60_RS06395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW60_RS06420	COG1595	DNA-templated transcription, initiation
EXW60_RS06430	COG0110	maltose O-acetyltransferase activity
EXW60_RS06435	COG0456	acetyltransferase
EXW60_RS06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW60_RS06445	COG0454	-acetyltransferase
EXW60_RS06450	COG0517	IMP dehydrogenase activity
EXW60_RS06455	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW60_RS06470	COG0745	RESPONSE REGULATOR receiver
EXW60_RS06475	COG5002	protein histidine kinase activity
EXW60_RS06480	COG0666	response to abiotic stimulus
EXW60_RS06490	COG1970	mechanosensitive ion channel activity
EXW60_RS06510	COG1609	Transcriptional regulator
EXW60_RS06525	COG4851	CamS sex pheromone cAM373 precursor
EXW60_RS06530	COG3118	belongs to the thioredoxin family
EXW60_RS06540	COG2309	aminopeptidase activity
EXW60_RS06560	COG0697	spore germination
EXW60_RS06565	COG0789	Transcriptional regulator
EXW60_RS06570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW60_RS06580	COG1674	ftsk spoiiie
EXW60_RS06595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW60_RS06600	COG4848	Belongs to the UPF0354 family
EXW60_RS06605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS06610	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW60_RS06615	COG1363	Peptidase, m42
EXW60_RS06625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS06630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW60_RS06640	COG0510	thiamine kinase activity
EXW60_RS06645	COG1523	belongs to the glycosyl hydrolase 13 family
EXW60_RS06655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW60_RS06660	COG1349	DNA-binding transcription factor activity
EXW60_RS06665	COG1187	pseudouridine synthase activity
EXW60_RS06670	COG2244	polysaccharide biosynthetic process
EXW60_RS06675	COG2081	HI0933 family
EXW60_RS06680	COG2814	Major facilitator Superfamily
EXW60_RS06690	COG3832	glyoxalase III activity
EXW60_RS06710	COG1329	Transcriptional regulator
EXW60_RS06735	COG0314	molybdopterin synthase activity
EXW60_RS06740	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW60_RS06745	COG0303	'Molybdopterin
EXW60_RS06750	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW60_RS06755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW60_RS06760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW60_RS06780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS06790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW60_RS06830	COG0495	leucyl-tRNA aminoacylation
EXW60_RS06835	COG2814	Major facilitator Superfamily
EXW60_RS06840	COG0475	glutathione-regulated potassium exporter activity
EXW60_RS06845	COG0490	domain, Protein
EXW60_RS06850	COG0582	viral genome integration into host DNA
EXW60_RS06860	COG1136	(ABC) transporter
EXW60_RS06880	COG1242	4 iron, 4 sulfur cluster binding
EXW60_RS06885	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW60_RS06900	COG2267	carboxylic ester hydrolase activity
EXW60_RS06905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW60_RS06910	COG0671	phosphoesterase, PA-phosphatase related
EXW60_RS06915	COG0438	transferase activity, transferring glycosyl groups
EXW60_RS06920	COG0746	molybdenum cofactor guanylyltransferase activity
EXW60_RS06925	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW60_RS06940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW60_RS06945	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW60_RS06985	COG5002	protein histidine kinase activity
EXW60_RS06990	COG3852	Histidine kinase
EXW60_RS06995	COG0753	catalase activity
EXW60_RS07000	COG2267	carboxylic ester hydrolase activity
EXW60_RS07010	COG1368	sulfuric ester hydrolase activity
EXW60_RS07020	COG4895	conserved protein (DUF2196)
EXW60_RS07035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW60_RS07040	COG1116	anion transmembrane transporter activity
EXW60_RS07045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW60_RS07065	COG0494	nUDIX hydrolase
EXW60_RS07100	COG2076	Multidrug Resistance protein
EXW60_RS07110	COG0789	Transcriptional regulator
EXW60_RS07115	COG1854	S-ribosylhomocysteine lyase activity
EXW60_RS07125	COG0288	reversible hydration of carbon dioxide
EXW60_RS07130	COG1271	oxidase subunit
EXW60_RS07135	COG1294	oxidase, subunit
EXW60_RS07160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS07180	COG1842	Phage shock protein A
EXW60_RS07205	COG3859	Proton-coupled thiamine transporter YuaJ
EXW60_RS07210	COG5002	protein histidine kinase activity
EXW60_RS07215	COG0745	RESPONSE REGULATOR receiver
EXW60_RS07240	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW60_RS07245	COG1597	lipid kinase activity
EXW60_RS07270	COG4977	sequence-specific DNA binding
EXW60_RS07280	COG0577	efflux transmembrane transporter activity
EXW60_RS07285	COG1136	(ABC) transporter
EXW60_RS07290	COG2207	Transcriptional regulator
EXW60_RS07290	COG3708	Transcriptional regulator
EXW60_RS07300	COG1131	(ABC) transporter
EXW60_RS07310	COG5658	integral membrane protein
EXW60_RS07315	COG0640	Transcriptional regulator
EXW60_RS07320	COG0745	RESPONSE REGULATOR receiver
EXW60_RS07325	COG2205	protein histidine kinase activity
EXW60_RS07330	COG0577	efflux transmembrane transporter activity
EXW60_RS07335	COG0577	efflux transmembrane transporter activity
EXW60_RS07340	COG1136	(ABC) transporter
EXW60_RS07345	COG0577	efflux transmembrane transporter activity
EXW60_RS07360	COG2188	Transcriptional regulator
EXW60_RS07380	COG3964	amidohydrolase
EXW60_RS07410	COG4948	Mandelate Racemase Muconate Lactonizing
EXW60_RS07415	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS07420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW60_RS07425	COG0596	Alpha beta hydrolase
EXW60_RS07430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW60_RS07435	COG1169	isochorismate synthase
EXW60_RS07440	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW60_RS07445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW60_RS07450	COG1278	Cold shock
EXW60_RS07460	COG0789	Transcriptional regulator
EXW60_RS07470	COG0058	SHG alpha-glucan phosphorylase activity
EXW60_RS07480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW60_RS07485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW60_RS07490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW60_RS07630	COG1285	pathogenesis
EXW60_RS07635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW60_RS07645	COG0166	Belongs to the GPI family
EXW60_RS07650	COG2155	Conserved Protein
EXW60_RS07655	COG1098	S1 RNA binding domain
EXW60_RS07660	COG0436	Aminotransferase
EXW60_RS07665	COG1522	sequence-specific DNA binding
EXW60_RS07670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW60_RS07675	COG2267	carboxylic ester hydrolase activity
EXW60_RS07685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW60_RS07705	COG5018	Exonuclease
EXW60_RS07710	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW60_RS07730	COG2050	protein possibly involved in aromatic compounds catabolism
EXW60_RS07740	COG1268	BioY protein
EXW60_RS07745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW60_RS07750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW60_RS07760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW60_RS07765	COG3584	3D domain protein
EXW60_RS07780	COG1252	NADH dehydrogenase
EXW60_RS07785	COG0492	ferredoxin-NADP+ reductase activity
EXW60_RS07790	COG3708	Transcriptional regulator
EXW60_RS07805	COG1683	Conserved Protein
EXW60_RS07825	COG0316	Belongs to the HesB IscA family
EXW60_RS07830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW60_RS07835	COG4844	belongs to the
EXW60_RS07840	COG1252	NADH dehydrogenase
EXW60_RS07850	COG0390	transport system, permease component
EXW60_RS07855	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW60_RS07900	COG4837	Protein of unknown function (DUF1462)
EXW60_RS07905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW60_RS07915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW60_RS07920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW60_RS07930	COG0647	UMP catabolic process
EXW60_RS07940	COG2445	Protein of unknown function DUF86
EXW60_RS07945	COG1494	fructose-1,6-bisphosphatase
EXW60_RS07960	COG4470	Protein conserved in bacteria
EXW60_RS07970	COG0789	Transcriptional regulator
EXW60_RS07975	COG4377	Putative membrane peptidase family (DUF2324)
EXW60_RS07995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW60_RS08000	COG0739	heme binding
EXW60_RS08010	COG3377	Domain of unknown function (DUF1805)
EXW60_RS08015	COG0737	Belongs to the 5'-nucleotidase family
EXW60_RS08020	COG1695	Transcriptional regulator
EXW60_RS08030	COG0719	Fe-S assembly protein
EXW60_RS08035	COG0822	iron-sulfur transferase activity
EXW60_RS08040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW60_RS08045	COG0719	Fe-S assembly protein
EXW60_RS08050	COG0396	ATPase activity
EXW60_RS08055	COG1464	Belongs to the NlpA lipoprotein family
EXW60_RS08060	COG1464	Belongs to the NlpA lipoprotein family
EXW60_RS08065	COG2011	ABC-type metal ion transport system permease component
EXW60_RS08080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS08085	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW60_RS08090	COG0509	glycine decarboxylation via glycine cleavage system
EXW60_RS08095	COG1393	Belongs to the ArsC family
EXW60_RS08150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS08155	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS08160	COG0183	Belongs to the thiolase family
EXW60_RS08165	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW60_RS08165	COG1024	Enoyl-CoA hydratase
EXW60_RS08175	COG1686	Belongs to the peptidase S11 family
EXW60_RS08180	COG0506	proline dehydrogenase activity
EXW60_RS08190	COG0011	TIGRFAM Protein of
EXW60_RS08195	COG0840	transmembrane signaling receptor activity
EXW60_RS08210	COG2814	Major facilitator Superfamily
EXW60_RS08215	COG0531	amino acid
EXW60_RS08240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS08270	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS08280	COG1376	ErfK ybiS ycfS ynhG family protein
EXW60_RS08285	COG0745	RESPONSE REGULATOR receiver
EXW60_RS08290	COG5002	protein histidine kinase activity
EXW60_RS08300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW60_RS08310	COG0840	transmembrane signaling receptor activity
EXW60_RS08315	COG0840	transmembrane signaling receptor activity
EXW60_RS08320	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW60_RS08325	COG3227	Zinc metalloprotease (Elastase)
EXW60_RS08330	COG1741	Belongs to the pirin family
EXW60_RS08345	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS08350	COG0475	glutathione-regulated potassium exporter activity
EXW60_RS08355	COG0490	domain, Protein
EXW60_RS08360	COG1115	amino acid carrier protein
EXW60_RS08365	COG0783	Belongs to the Dps family
EXW60_RS08375	COG2318	DinB family
EXW60_RS08385	COG1611	Belongs to the LOG family
EXW60_RS08395	COG1528	Iron-storage protein
EXW60_RS08400	COG2311	Membrane
EXW60_RS08405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS08410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS08415	COG1115	amino acid carrier protein
EXW60_RS08420	COG2910	NAD(P)H-binding
EXW60_RS08445	COG0656	L-ascorbic acid biosynthetic process
EXW60_RS08450	COG2814	Major facilitator Superfamily
EXW60_RS08455	COG1733	regulation of RNA biosynthetic process
EXW60_RS08465	COG1252	NADH dehydrogenase
EXW60_RS08485	COG0840	transmembrane signaling receptor activity
EXW60_RS08485	COG3290	protein histidine kinase activity
EXW60_RS08495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW60_RS08510	COG3655	Transcriptional regulator
EXW60_RS08525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS08535	COG1733	regulation of RNA biosynthetic process
EXW60_RS08540	COG0778	Nitroreductase
EXW60_RS08545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW60_RS08550	COG4224	UPF0291 protein
EXW60_RS08555	COG1522	sequence-specific DNA binding
EXW60_RS08560	COG0288	reversible hydration of carbon dioxide
EXW60_RS08565	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW60_RS08570	COG2233	PERMEase
EXW60_RS08595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS08615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW60_RS08620	COG0557	exoribonuclease II activity
EXW60_RS08625	COG1647	Serine aminopeptidase, S33
EXW60_RS08630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW60_RS08635	COG1346	cytolysis
EXW60_RS08650	COG0148	phosphopyruvate hydratase activity
EXW60_RS08660	COG0149	triose-phosphate isomerase activity
EXW60_RS08665	COG0126	phosphoglycerate kinase activity
EXW60_RS08670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW60_RS08685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW60_RS08715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW60_RS08730	COG2323	membrane
EXW60_RS08740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW60_RS08745	COG1481	regulation of sporulation
EXW60_RS08750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW60_RS08755	COG1660	Displays ATPase and GTPase activities
EXW60_RS08760	COG1051	belongs to the nudix hydrolase family
EXW60_RS08770	COG0492	ferredoxin-NADP+ reductase activity
EXW60_RS08775	COG0457	Tetratricopeptide repeat
EXW60_RS08780	COG0110	maltose O-acetyltransferase activity
EXW60_RS08785	COG0546	phosphoglycolate phosphatase activity
EXW60_RS08790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW60_RS08795	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW60_RS08800	COG1950	PFAM Membrane protein of
EXW60_RS08810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW60_RS08830	COG0789	Transcriptional regulator
EXW60_RS08865	COG0583	DNA-binding transcription factor activity
EXW60_RS08870	COG0789	Transcriptional regulator
EXW60_RS08875	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW60_RS08880	COG0488	(ABC) transporter
EXW60_RS08890	COG1132	(ABC) transporter
EXW60_RS08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW60_RS08900	COG3409	Peptidoglycan-binding domain 1 protein
EXW60_RS08900	COG0793	Belongs to the peptidase S41A family
EXW60_RS08905	COG2177	Part of the ABC transporter FtsEX involved in
EXW60_RS08910	COG2884	Cell division ATP-binding protein ftsE
EXW60_RS08935	COG1131	(ABC) transporter
EXW60_RS08970	COG1278	Cold shock
EXW60_RS08975	COG1040	competence protein
EXW60_RS08980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW60_RS08985	COG1388	LysM domain
EXW60_RS08985	COG0791	NLP P60 protein
EXW60_RS08990	COG1733	regulation of RNA biosynthetic process
EXW60_RS08995	COG1307	EDD domain protein, DegV family
EXW60_RS09000	COG1739	Uncharacterized protein family UPF0029
EXW60_RS09005	COG1316	TRANSCRIPTIONal
EXW60_RS09010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW60_RS09015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW60_RS09020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW60_RS09030	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW60_RS09030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW60_RS09050	COG1486	melibiose metabolic process
EXW60_RS09055	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW60_RS09060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW60_RS09080	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW60_RS09090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW60_RS09095	COG1301	dicarboxylic acid transport
EXW60_RS09110	COG1511	domain protein
EXW60_RS09115	COG0583	DNA-binding transcription factor activity
EXW60_RS09120	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW60_RS09130	COG1271	oxidase subunit
EXW60_RS09135	COG1294	oxidase, subunit
EXW60_RS09140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW60_RS09145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW60_RS09150	COG1620	l-lactate permease
EXW60_RS09160	COG2389	metal-binding protein
EXW60_RS09170	COG1368	sulfuric ester hydrolase activity
EXW60_RS09180	COG1388	LysM domain
EXW60_RS09180	COG0791	NLP P60 protein
EXW60_RS09185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS09195	COG1215	transferase activity, transferring glycosyl groups
EXW60_RS09200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW60_RS09205	COG3584	3D domain protein
EXW60_RS09205	COG1388	LysM domain
EXW60_RS09230	COG4715	Zinc finger, swim domain protein
EXW60_RS09235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW60_RS09275	COG0577	efflux transmembrane transporter activity
EXW60_RS09280	COG1136	(ABC) transporter
EXW60_RS09315	COG3850	Histidine kinase
EXW60_RS09315	COG5002	protein histidine kinase activity
EXW60_RS09320	COG0745	RESPONSE REGULATOR receiver
EXW60_RS09325	COG1316	TRANSCRIPTIONal
EXW60_RS09355	COG1134	teichoic acid transport
EXW60_RS09360	COG1682	transport, permease protein
EXW60_RS09365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW60_RS09375	COG1215	transferase activity, transferring glycosyl groups
EXW60_RS09390	COG0463	Glycosyl transferase, family 2
EXW60_RS09390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW60_RS09410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW60_RS09420	COG1609	Transcriptional regulator
EXW60_RS09425	COG0726	polysaccharide deacetylase
EXW60_RS09435	COG0739	heme binding
EXW60_RS09450	COG3279	Response regulator of the LytR AlgR family
EXW60_RS09455	COG2385	sporulation resulting in formation of a cellular spore
EXW60_RS09470	COG4836	Membrane
EXW60_RS09475	COG1007	ATP synthesis coupled electron transport
EXW60_RS09480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW60_RS09485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW60_RS09490	COG0713	ATP synthesis coupled electron transport
EXW60_RS09495	COG0839	Belongs to the complex I subunit 6 family
EXW60_RS09505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW60_RS09510	COG0649	NAD binding
EXW60_RS09515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW60_RS09520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW60_RS09525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW60_RS09530	COG3300	MHYT domain
EXW60_RS09530	COG5001	Diguanylate cyclase
EXW60_RS09545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW60_RS09550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW60_RS09555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW60_RS09560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW60_RS09565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW60_RS09570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW60_RS09580	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW60_RS09605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW60_RS09615	COG0698	ribose 5-phosphate isomerase
EXW60_RS09625	COG2190	(PTS) system
EXW60_RS09630	COG2259	Doxx family
EXW60_RS09635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW60_RS09645	COG1971	Probably functions as a manganese efflux pump
EXW60_RS09650	COG0009	L-threonylcarbamoyladenylate synthase
EXW60_RS09665	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW60_RS09670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW60_RS09675	COG1435	thymidine kinase activity
EXW60_RS09685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW60_RS09690	COG1494	fructose-1,6-bisphosphatase
EXW60_RS09710	COG4821	SIS domain
EXW60_RS09715	COG0504	CTP synthase activity
EXW60_RS09720	COG3343	RNA polymerase activity
EXW60_RS09730	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS09735	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS09740	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW60_RS09745	COG0183	Belongs to the thiolase family
EXW60_RS09750	COG0247	lactate metabolic process
EXW60_RS09750	COG2181	nitrate reductase activity
EXW60_RS09755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW60_RS09760	COG4294	response to UV
EXW60_RS09765	COG5001	Diguanylate cyclase
EXW60_RS09765	COG3300	MHYT domain
EXW60_RS09780	COG3227	Zinc metalloprotease (Elastase)
EXW60_RS09785	COG2197	response regulator
EXW60_RS09790	COG4585	Histidine kinase
EXW60_RS09795	COG0842	Transport permease protein
EXW60_RS09800	COG1131	(ABC) transporter
EXW60_RS09805	COG0024	Methionine aminopeptidase
EXW60_RS09815	COG2234	aminopeptidase activity
EXW60_RS09835	COG4506	Protein conserved in bacteria
EXW60_RS09840	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW60_RS09855	COG0010	Belongs to the arginase family
EXW60_RS09860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW60_RS09865	COG2814	Major facilitator Superfamily
EXW60_RS09870	COG0789	Transcriptional regulator
EXW60_RS09875	COG0584	glycerophosphoryl diester phosphodiesterase
EXW60_RS09880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS09890	COG1994	Peptidase M50
EXW60_RS09900	COG1078	dGTPase activity
EXW60_RS09905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS09910	COG1120	ATPase activity
EXW60_RS09915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS09920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS09925	COG4844	belongs to the
EXW60_RS09940	COG0280	phosphate acetyltransferase
EXW60_RS09945	COG3253	May function as heme-dependent peroxidase
EXW60_RS09955	COG3773	Cell wall hydrolase
EXW60_RS09965	COG2363	Small membrane protein
EXW60_RS09980	COG2233	PERMEase
EXW60_RS09985	COG0561	phosphatase activity
EXW60_RS09990	COG2814	Major facilitator Superfamily
EXW60_RS09995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW60_RS10000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW60_RS10005	COG1131	(ABC) transporter
EXW60_RS10010	COG2755	lipolytic protein G-D-S-L family
EXW60_RS10015	COG1609	Transcriptional regulator
EXW60_RS10025	COG0460	homoserine dehydrogenase
EXW60_RS10030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW60_RS10035	COG2873	o-acetylhomoserine
EXW60_RS10045	COG1011	Hydrolase
EXW60_RS10050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW60_RS10060	COG2197	response regulator
EXW60_RS10065	COG2203	Gaf domain
EXW60_RS10065	COG4585	Histidine kinase
EXW60_RS10070	COG0351	phosphomethylpyrimidine kinase
EXW60_RS10075	COG3706	GGDEF domain
EXW60_RS10080	COG2879	small protein
EXW60_RS10085	COG1966	Carbon starvation protein
EXW60_RS10090	COG3279	Response regulator of the LytR AlgR family
EXW60_RS10095	COG0477	Major facilitator Superfamily
EXW60_RS10120	COG0840	transmembrane signaling receptor activity
EXW60_RS10130	COG1607	acyl-coa hydrolase
EXW60_RS10135	COG1216	Glycosyl transferase, family 2
EXW60_RS10145	COG1216	Glycosyl transferase, family 2
EXW60_RS10155	COG4485	Bacterial membrane protein, YfhO
EXW60_RS10160	COG0463	Glycosyl transferase, family 2
EXW60_RS10170	COG1309	transcriptional regulator
EXW60_RS10175	COG0488	(ABC) transporter
EXW60_RS10180	COG1309	transcriptional regulator
EXW60_RS10185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW60_RS10190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW60_RS10190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW60_RS10195	COG0628	permease
EXW60_RS10205	COG1380	Effector of murein hydrolase LrgA
EXW60_RS10210	COG3279	Response regulator of the LytR AlgR family
EXW60_RS10215	COG3275	phosphorelay sensor kinase activity
EXW60_RS10220	COG2814	Major facilitator Superfamily
EXW60_RS10225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW60_RS10230	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW60_RS10235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW60_RS10285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW60_RS10290	COG1272	protein, Hemolysin III
EXW60_RS10315	COG1164	Oligoendopeptidase f
EXW60_RS10325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW60_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW60_RS10340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW60_RS10345	COG4853	Protein conserved in bacteria
EXW60_RS10355	COG5002	protein histidine kinase activity
EXW60_RS10360	COG0745	RESPONSE REGULATOR receiver
EXW60_RS10390	COG0305	Participates in initiation and elongation during chromosome replication
EXW60_RS10395	COG0359	binds to the 23S rRNA
EXW60_RS10400	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW60_RS10405	COG4241	membrane
EXW60_RS10415	COG0629	single-stranded DNA binding
EXW60_RS10420	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW60_RS10425	COG0012	GTP binding
EXW60_RS10430	COG4481	Protein conserved in bacteria
EXW60_RS10435	COG0668	transmembrane transport
EXW60_RS10445	COG1475	DNA binding
EXW60_RS10450	COG1192	Involved in chromosome partitioning
EXW60_RS10455	COG1475	DNA binding
EXW60_RS10460	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW60_RS10465	COG0445	tRNA wobble uridine modification
EXW60_RS10470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW60_RS10475	COG1847	R3H domain protein
EXW60_RS10480	COG0706	membrane insertase activity
EXW60_RS10485	COG0594	ribonuclease P activity
EXW60_RS10490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW60_RS10495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW60_RS10500	COG0592	DNA-directed DNA polymerase activity
EXW60_RS10505	COG2501	S4 domain
EXW60_RS10510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW60_RS10515	COG0187	DNA topoisomerase II activity
EXW60_RS10520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW60_RS10555	COG0516	GMP reductase activity
EXW60_RS10555	COG0517	IMP dehydrogenase activity
EXW60_RS10560	COG1686	Belongs to the peptidase S11 family
EXW60_RS10565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW60_RS10570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW60_RS10590	COG1428	Deoxynucleoside kinase
EXW60_RS10595	COG1428	Deoxynucleoside kinase
EXW60_RS10600	COG1335	isochorismatase
EXW60_RS10605	COG0590	tRNA wobble adenosine to inosine editing
EXW60_RS10615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW60_RS10620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW60_RS10625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW60_RS10670	COG1982	Orn Lys Arg decarboxylase major
EXW60_RS10675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW60_RS10680	COG0470	DNA polymerase III
EXW60_RS10685	COG1774	PSP1 C-terminal conserved region
EXW60_RS10690	COG4467	Involved in initiation control of chromosome replication
EXW60_RS10695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW60_RS10705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW60_RS10710	COG2002	toxin-antitoxin pair type II binding
EXW60_RS10720	COG0084	hydrolase, TatD family'
EXW60_RS10730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW60_RS10740	COG4466	Protein conserved in bacteria
EXW60_RS10750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW60_RS10755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW60_RS10760	COG0251	oxidation-reduction process
EXW60_RS10765	COG2088	sporulation resulting in formation of a cellular spore
EXW60_RS10770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW60_RS10790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW60_RS10795	COG2002	toxin-antitoxin pair type II binding
EXW60_RS10800	COG2244	polysaccharide biosynthetic process
EXW60_RS10805	COG3956	TIGRFAM MazG family protein
EXW60_RS10810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW60_RS10830	COG1098	S1 RNA binding domain
EXW60_RS10845	COG2208	phosphoserine phosphatase activity
EXW60_RS10855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW60_RS10860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW60_RS10865	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW60_RS10870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW60_RS10875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW60_RS10880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW60_RS10885	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW60_RS10890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW60_RS10895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW60_RS10900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW60_RS10905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW60_RS10910	COG1396	sequence-specific DNA binding
EXW60_RS10915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW60_RS10920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW60_RS11005	COG3880	PFAM UvrB UvrC protein
EXW60_RS11010	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW60_RS11015	COG0542	response to heat
EXW60_RS11020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW60_RS11025	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW60_RS11030	COG4956	integral membrane protein (PIN domain superfamily)
EXW60_RS11035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW60_RS11045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW60_RS11050	COG1045	serine acetyltransferase
EXW60_RS11055	COG0215	cysteine-tRNA ligase activity
EXW60_RS11065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW60_RS11070	COG3688	RNA-binding protein containing a PIN domain
EXW60_RS11080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW60_RS11085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW60_RS11090	COG0250	Participates in transcription elongation, termination and antitermination
EXW60_RS11095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW60_RS11100	COG0081	regulation of translation
EXW60_RS11105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW60_RS11110	COG0222	ribosome binding
EXW60_RS11115	COG2813	Specifically methylates the guanine in position
EXW60_RS11120	COG0085	RNA polymerase activity
EXW60_RS11125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW60_RS11130	COG1358	cellular component organization or biogenesis
EXW60_RS11135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW60_RS11140	COG0049	tRNA binding
EXW60_RS11145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW60_RS11150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW60_RS11155	COG0051	transcription antitermination factor activity, RNA binding
EXW60_RS11160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW60_RS11165	COG0088	Forms part of the polypeptide exit tunnel
EXW60_RS11170	COG0089	rRNA binding
EXW60_RS11175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW60_RS11180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW60_RS11185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW60_RS11195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW60_RS11200	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW60_RS11205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW60_RS11210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW60_RS11215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW60_RS11220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW60_RS11230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW60_RS11240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW60_RS11250	COG1841	ribosomal large subunit assembly
EXW60_RS11255	COG0200	Binds to the 23S rRNA
EXW60_RS11260	COG0201	protein transport
EXW60_RS11265	COG0563	adenylate kinase activity
EXW60_RS11270	COG0024	Methionine aminopeptidase
EXW60_RS11280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW60_RS11285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW60_RS11290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW60_RS11315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW60_RS11325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW60_RS11330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW60_RS11340	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS11345	COG0489	protein tyrosine kinase activity
EXW60_RS11355	COG2194	sulfuric ester hydrolase activity
EXW60_RS11360	COG0726	polysaccharide deacetylase
EXW60_RS11440	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW60_RS11445	COG4856	YbbR-like protein
EXW60_RS11450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW60_RS11460	COG1506	peptidase
EXW60_RS11460	COG0823	Involved in the tonB-independent uptake of proteins
EXW60_RS11460	COG4946	Tricorn protease homolog
EXW60_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS11490	COG2011	ABC-type metal ion transport system permease component
EXW60_RS11500	COG1464	Belongs to the NlpA lipoprotein family
EXW60_RS11505	COG0604	alcohol dehydrogenase
EXW60_RS11515	COG0277	FAD linked oxidase domain protein
EXW60_RS11520	COG2271	Major facilitator Superfamily
EXW60_RS11530	COG2814	Major facilitator Superfamily
EXW60_RS11545	COG0601	transmembrane transport
EXW60_RS11550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW60_RS11555	COG0444	Belongs to the ABC transporter superfamily
EXW60_RS11560	COG4608	Belongs to the ABC transporter superfamily
EXW60_RS11565	COG4166	transmembrane transport
EXW60_RS11575	COG2207	Transcriptional regulator
EXW60_RS11590	COG4166	transmembrane transport
EXW60_RS11595	COG4166	transmembrane transport
EXW60_RS11600	COG0656	L-ascorbic acid biosynthetic process
EXW60_RS11605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW60_RS11620	COG4149	molybdate abc transporter
EXW60_RS11625	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW60_RS11630	COG1910	domain protein
EXW60_RS11645	COG0697	spore germination
EXW60_RS11660	COG0204	Acyl-transferase
EXW60_RS11670	COG1609	Transcriptional regulator
EXW60_RS11680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS11695	COG5298	Protein conserved in bacteria
EXW60_RS11715	COG0488	(ABC) transporter
EXW60_RS11725	COG0747	negative chemotaxis
EXW60_RS11730	COG0747	negative chemotaxis
EXW60_RS11735	COG0601	transmembrane transport
EXW60_RS11740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW60_RS11745	COG0444	Belongs to the ABC transporter superfamily
EXW60_RS11750	COG4608	Belongs to the ABC transporter superfamily
EXW60_RS11755	COG0561	phosphatase activity
EXW60_RS11780	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW60_RS11785	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW60_RS11795	COG0531	amino acid
EXW60_RS11800	COG2814	Major facilitator Superfamily
EXW60_RS11810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW60_RS11820	COG4294	response to UV
EXW60_RS11825	COG0705	Rhomboid family
EXW60_RS11830	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW60_RS11835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW60_RS11840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW60_RS11845	COG0864	Transcriptional regulator
EXW60_RS11850	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW60_RS11855	COG2183	response to ionizing radiation
EXW60_RS11955	COG0802	atpase or kinase
EXW60_RS11960	COG1214	PFAM Peptidase M22, glycoprotease
EXW60_RS11965	COG0456	acetyltransferase
EXW60_RS11975	COG0488	(ABC) transporter
EXW60_RS11980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW60_RS11990	COG1266	CAAX protease self-immunity
EXW60_RS11995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW60_RS12000	COG0459	protein refolding
EXW60_RS12005	COG0519	Catalyzes the synthesis of GMP from XMP
EXW60_RS12005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW60_RS12010	COG2252	PERMEase
EXW60_RS12020	COG5002	protein histidine kinase activity
EXW60_RS12045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW60_RS12075	COG2226	methyltransferase
EXW60_RS12135	COG2205	protein histidine kinase activity
EXW60_RS12140	COG0745	RESPONSE REGULATOR receiver
EXW60_RS12160	COG0697	spore germination
EXW60_RS12185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW60_RS12190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW60_RS12195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW60_RS12200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW60_RS12205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW60_RS12210	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW60_RS12215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW60_RS12220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW60_RS12225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW60_RS12230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW60_RS12235	COG0138	bifunctional purine biosynthesis protein purh
EXW60_RS12240	COG0151	Belongs to the GarS family
EXW60_RS12260	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW60_RS12265	COG0210	DNA helicase
EXW60_RS12270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW60_RS12275	COG4851	CamS sex pheromone cAM373 precursor
EXW60_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS12290	COG1335	isochorismatase
EXW60_RS12300	COG2011	ABC-type metal ion transport system permease component
EXW60_RS12305	COG1464	Belongs to the NlpA lipoprotein family
EXW60_RS12320	COG0003	Pfam Anion-transporting ATPase
EXW60_RS12325	COG1846	Transcriptional regulator
EXW60_RS12330	COG4682	membrane
EXW60_RS12340	COG0154	amidase activity
EXW60_RS12345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW60_RS12350	COG1597	lipid kinase activity
EXW60_RS12360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW60_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS12375	COG2076	Multidrug Resistance protein
EXW60_RS12380	COG2309	aminopeptidase activity
EXW60_RS12395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS12405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW60_RS12410	COG5002	protein histidine kinase activity
EXW60_RS12420	COG4807	Protein conserved in bacteria
EXW60_RS12445	COG1757	Na H antiporter
EXW60_RS12450	COG1473	amidohydrolase
EXW60_RS12465	COG0450	alkyl hydroperoxide reductase
EXW60_RS12475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW60_RS12485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS12495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS12500	COG0492	ferredoxin-NADP+ reductase activity
EXW60_RS12510	COG0166	Belongs to the GPI family
EXW60_RS12535	COG5002	protein histidine kinase activity
EXW60_RS12555	COG3541	Predicted nucleotidyltransferase
EXW60_RS12560	COG0723	plastoquinol--plastocyanin reductase activity
EXW60_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW60_RS12570	COG0765	amino acid transport
EXW60_RS12575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS12585	COG0840	transmembrane signaling receptor activity
EXW60_RS12590	COG0277	FAD linked oxidase domain protein
EXW60_RS12595	COG0366	Alpha amylase catalytic
EXW60_RS12600	COG1263	PTS System
EXW60_RS12600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW60_RS12600	COG2190	(PTS) system
EXW60_RS12620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW60_RS12625	COG0352	thiamine-phosphate diphosphorylase activity
EXW60_RS12630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW60_RS12645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW60_RS12650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW60_RS12655	COG1116	anion transmembrane transporter activity
EXW60_RS12660	COG0488	(ABC) transporter
EXW60_RS12695	COG2270	Major facilitator Superfamily
EXW60_RS12725	COG2310	stress, protein
EXW60_RS12730	COG2310	stress, protein
EXW60_RS12735	COG2310	stress, protein
EXW60_RS12740	COG0861	Integral membrane protein TerC family
EXW60_RS12750	COG3853	Toxic anion resistance protein (TelA)
EXW60_RS12760	COG4840	Belongs to the UPF0435 family
EXW60_RS12765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW60_RS12775	COG1295	ribonuclease BN
EXW60_RS12780	COG2217	Heavy metal translocating P-type atpase
EXW60_RS12785	COG0697	spore germination
EXW60_RS12805	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS12820	COG3871	stress protein (general stress protein 26)
EXW60_RS12825	COG0387	Pfam Sodium calcium exchanger
EXW60_RS12835	COG0535	radical SAM domain protein
EXW60_RS12855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW60_RS12875	COG3829	transcription factor binding
EXW60_RS12885	COG0833	amino acid
EXW60_RS12890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW60_RS12910	COG2066	Belongs to the glutaminase family
EXW60_RS12915	COG1263	PTS System
EXW60_RS12915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW60_RS12920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS12935	COG1216	Glycosyl transferase, family 2
EXW60_RS12945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW60_RS12945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW60_RS12950	COG0463	Glycosyl transferase, family 2
EXW60_RS12965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW60_RS12970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW60_RS12985	COG1228	amidohydrolase
EXW60_RS12990	COG1090	epimerase
EXW60_RS12995	COG2137	regulation of response to DNA damage stimulus
EXW60_RS13020	COG1988	membrane-bound metal-dependent
EXW60_RS13025	COG1194	a g-specific adenine glycosylase
EXW60_RS13050	COG3557	Belongs to the UPF0374 family
EXW60_RS13055	COG1132	(ABC) transporter
EXW60_RS13060	COG4129	membrane
EXW60_RS13065	COG0067	glutamate synthase
EXW60_RS13065	COG0069	glutamate synthase activity
EXW60_RS13065	COG0070	glutamate synthase
EXW60_RS13070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW60_RS13075	COG4555	ABC transporter
EXW60_RS13095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW60_RS13100	COG0735	belongs to the Fur family
EXW60_RS13205	COG4974	Belongs to the 'phage' integrase family
EXW60_RS13290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW60_RS13295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW60_RS13315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW60_RS13325	COG2766	serine protein kinase
EXW60_RS13330	COG2718	Belongs to the UPF0229 family
EXW60_RS13345	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW60_RS13350	COG2268	Band 7 protein
EXW60_RS13360	COG3290	protein histidine kinase activity
EXW60_RS13365	COG4565	transcriptional regulatory protein
EXW60_RS13370	COG2851	Citrate transporter
EXW60_RS13395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW60_RS13400	COG3842	ATPase activity
EXW60_RS13405	COG1175	transmembrane transport
EXW60_RS13410	COG0395	ABC-type sugar transport system, permease component
EXW60_RS13420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW60_RS13425	COG0745	RESPONSE REGULATOR receiver
EXW60_RS13430	COG5002	protein histidine kinase activity
EXW60_RS13440	COG4990	cell redox homeostasis
EXW60_RS13450	COG3290	protein histidine kinase activity
EXW60_RS13455	COG4565	transcriptional regulatory protein
EXW60_RS13460	COG3493	citrate carrier protein
EXW60_RS13465	COG0281	malic enzyme
EXW60_RS13475	COG0697	spore germination
EXW60_RS13480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS13490	COG5002	protein histidine kinase activity
EXW60_RS13495	COG0745	RESPONSE REGULATOR receiver
EXW60_RS13500	COG0456	acetyltransferase
EXW60_RS13505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW60_RS13510	COG3383	formate dehydrogenase (NAD+) activity
EXW60_RS13515	COG2427	Protein of unknown function (DUF1641)
EXW60_RS13530	COG0531	amino acid
EXW60_RS13540	COG0640	Transcriptional regulator
EXW60_RS13545	COG2217	Heavy metal translocating P-type atpase
EXW60_RS13550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW60_RS13565	COG3227	Zinc metalloprotease (Elastase)
EXW60_RS13585	COG2720	vancomycin resistance protein
EXW60_RS13590	COG1316	TRANSCRIPTIONal
EXW60_RS13595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS13600	COG0346	lactoylglutathione lyase activity
EXW60_RS13605	COG1253	flavin adenine dinucleotide binding
EXW60_RS13610	COG1027	Aspartate ammonia-lyase
EXW60_RS13615	COG1620	l-lactate permease
EXW60_RS13620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS13635	COG3104	oligopeptide transport
EXW60_RS13640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS13645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS13650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW60_RS13660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW60_RS13665	COG0156	8-amino-7-oxononanoate synthase activity
EXW60_RS13670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW60_RS13680	COG4548	von Willebrand factor, type A
EXW60_RS13685	COG0714	Associated with various cellular activities
EXW60_RS13705	COG0531	amino acid
EXW60_RS13710	COG2188	Transcriptional regulator
EXW60_RS13715	COG1263	PTS System
EXW60_RS13715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW60_RS13720	COG0366	Alpha amylase catalytic
EXW60_RS13735	COG0697	spore germination
EXW60_RS13740	COG4585	Histidine kinase
EXW60_RS13750	COG1404	Belongs to the peptidase S8 family
EXW60_RS13765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW60_RS13770	COG1115	amino acid carrier protein
EXW60_RS13775	COG1126	abc transporter atp-binding protein
EXW60_RS13780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS13785	COG0765	amino acid transport
EXW60_RS13790	COG0765	amino acid transport
EXW60_RS13795	COG0833	amino acid
EXW60_RS13820	COG2378	regulation of single-species biofilm formation
EXW60_RS13825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW60_RS13830	COG5002	protein histidine kinase activity
EXW60_RS13850	COG2814	Major facilitator Superfamily
EXW60_RS13855	COG0659	secondary active sulfate transmembrane transporter activity
EXW60_RS13870	COG0747	negative chemotaxis
EXW60_RS13880	COG0601	transmembrane transport
EXW60_RS13885	COG4608	Belongs to the ABC transporter superfamily
EXW60_RS13895	COG2271	Major facilitator Superfamily
EXW60_RS13900	COG1846	Transcriptional regulator
EXW60_RS13905	COG0477	Major facilitator Superfamily
EXW60_RS13910	COG1609	Transcriptional regulator
EXW60_RS13915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW60_RS13920	COG1869	D-ribose catabolic process
EXW60_RS13930	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW60_RS13935	COG1879	ABC-type sugar transport system periplasmic component
EXW60_RS13965	COG1063	alcohol dehydrogenase
EXW60_RS13980	COG3568	Endonuclease Exonuclease Phosphatase
EXW60_RS14010	COG0840	transmembrane signaling receptor activity
EXW60_RS14015	COG3583	domain protein
EXW60_RS14015	COG3584	3D domain protein
EXW60_RS14020	COG1476	TRANSCRIPTIONal
EXW60_RS14040	COG3104	oligopeptide transport
EXW60_RS14045	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS14060	COG1113	amino acid transport
EXW60_RS14065	COG2252	PERMEase
EXW60_RS14080	COG2153	protein acetylation
EXW60_RS14090	COG0569	domain protein
EXW60_RS14090	COG0475	glutathione-regulated potassium exporter activity
EXW60_RS14100	COG1845	cytochrome c oxidase, subunit III
EXW60_RS14105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW60_RS14115	COG0833	amino acid
EXW60_RS14120	COG4990	cell redox homeostasis
EXW60_RS14135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW60_RS14140	COG0697	spore germination
EXW60_RS14145	COG0531	amino acid
EXW60_RS14155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW60_RS14160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW60_RS14170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW60_RS14175	COG0573	inorganic phosphate transmembrane transporter activity
EXW60_RS14180	COG0581	inorganic phosphate transmembrane transporter activity
EXW60_RS14185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW60_RS14305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW60_RS14320	COG4991	sh3 domain protein
EXW60_RS14320	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS14320	COG3103	Sh3 type 3 domain protein
EXW60_RS14325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW60_RS14330	COG1116	anion transmembrane transporter activity
EXW60_RS14335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW60_RS14340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW60_RS14345	COG0352	thiamine-phosphate diphosphorylase activity
EXW60_RS14350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW60_RS14355	COG2104	thiamine diphosphate biosynthetic process
EXW60_RS14365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW60_RS14370	COG0351	phosphomethylpyrimidine kinase
EXW60_RS14395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW60_RS14400	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW60_RS14405	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW60_RS14410	COG2205	protein histidine kinase activity
EXW60_RS14415	COG2814	Major facilitator Superfamily
EXW60_RS14420	COG1846	Transcriptional regulator
EXW60_RS14440	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW60_RS14445	COG1129	ABC transporter
EXW60_RS14450	COG1879	ABC-type sugar transport system periplasmic component
EXW60_RS14455	COG2252	PERMEase
EXW60_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS14520	COG0778	Nitroreductase
EXW60_RS14525	COG2719	SpoVR family
EXW60_RS14560	COG1937	Protein conserved in bacteria
EXW60_RS14565	COG0425	Belongs to the sulfur carrier protein TusA family
EXW60_RS14565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS14570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS14570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS14575	COG0425	Belongs to the sulfur carrier protein TusA family
EXW60_RS14580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS14580	COG0425	Belongs to the sulfur carrier protein TusA family
EXW60_RS14585	COG2210	Belongs to the sulfur carrier protein TusA family
EXW60_RS14590	COG0730	response to heat
EXW60_RS14600	COG1316	TRANSCRIPTIONal
EXW60_RS14620	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW60_RS14635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW60_RS14635	COG3711	transcriptional antiterminator
EXW60_RS14640	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW60_RS14645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW60_RS14670	COG3584	3D domain protein
EXW60_RS14670	COG1388	LysM domain
EXW60_RS14675	COG0577	efflux transmembrane transporter activity
EXW60_RS14680	COG1136	(ABC) transporter
EXW60_RS14690	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW60_RS14705	COG0577	efflux transmembrane transporter activity
EXW60_RS14710	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS14715	COG3546	catalase activity
EXW60_RS14740	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS14775	COG0531	amino acid
EXW60_RS14790	COG1737	Transcriptional regulator
EXW60_RS14795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW60_RS14800	COG1263	PTS System
EXW60_RS14800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW60_RS14810	COG2259	Doxx family
EXW60_RS14830	COG0697	spore germination
EXW60_RS14835	COG1522	sequence-specific DNA binding
EXW60_RS14845	COG0300	oxidoreductase activity
EXW60_RS14860	COG2076	Multidrug Resistance protein
EXW60_RS14865	COG1309	transcriptional regulator
EXW60_RS14870	COG2814	Major facilitator Superfamily
EXW60_RS14875	COG1733	regulation of RNA biosynthetic process
EXW60_RS14900	COG0693	protein deglycase activity
EXW60_RS14910	COG0531	amino acid
EXW60_RS14915	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS14920	COG1132	(ABC) transporter
EXW60_RS14925	COG1132	(ABC) transporter
EXW60_RS14930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW60_RS14935	COG0765	amino acid transport
EXW60_RS14940	COG1126	abc transporter atp-binding protein
EXW60_RS14955	COG0189	ligase activity
EXW60_RS14965	COG4399	Belongs to the UPF0754 family
EXW60_RS14970	COG3679	Belongs to the UPF0342 family
EXW60_RS14985	COG0028	Belongs to the TPP enzyme family
EXW60_RS14990	COG3527	Alpha-acetolactate decarboxylase
EXW60_RS14995	COG0463	Glycosyl transferase, family 2
EXW60_RS15000	COG1216	Glycosyl transferase, family 2
EXW60_RS15005	COG2094	Belongs to the DNA glycosylase MPG family
EXW60_RS15010	COG0561	phosphatase activity
EXW60_RS15020	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS15020	COG3409	Peptidoglycan-binding domain 1 protein
EXW60_RS15025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW60_RS15030	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS15035	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS15045	COG0789	Transcriptional regulator
EXW60_RS15045	COG4978	Transcriptional regulator
EXW60_RS15055	COG0659	secondary active sulfate transmembrane transporter activity
EXW60_RS15070	COG0653	protein targeting
EXW60_RS15075	COG2244	polysaccharide biosynthetic process
EXW60_RS15085	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS15090	COG4196	transglutaminase domain protein
EXW60_RS15115	COG1024	Enoyl-CoA hydratase
EXW60_RS15135	COG1363	Peptidase, m42
EXW60_RS15150	COG2318	DinB family
EXW60_RS15170	COG0579	oxidoreductase
EXW60_RS15220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW60_RS15225	COG0444	Belongs to the ABC transporter superfamily
EXW60_RS15230	COG4608	Belongs to the ABC transporter superfamily
EXW60_RS15255	COG0477	Major facilitator Superfamily
EXW60_RS15260	COG3290	protein histidine kinase activity
EXW60_RS15265	COG4565	transcriptional regulatory protein
EXW60_RS15270	COG3181	Tripartite tricarboxylate transporter family receptor
EXW60_RS15340	COG0305	Participates in initiation and elongation during chromosome replication
EXW60_RS15375	COG0477	Major facilitator Superfamily
EXW60_RS15415	COG2814	Major facilitator Superfamily
EXW60_RS15420	COG0640	Transcriptional regulator
EXW60_RS15455	COG2376	Dihydroxyacetone kinase
EXW60_RS15465	COG2376	Dihydroxyacetone kinase
EXW60_RS15490	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW60_RS15510	COG2720	vancomycin resistance protein
EXW60_RS15565	COG0825	malonyl-CoA metabolic process
EXW60_RS15585	COG3237	CsbD-like
EXW60_RS15605	COG2172	sigma factor antagonist activity
EXW60_RS15610	COG1191	sigma factor activity
EXW60_RS15620	COG2208	phosphoserine phosphatase activity
EXW60_RS15625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW60_RS15630	COG2205	protein histidine kinase activity
EXW60_RS15630	COG5002	protein histidine kinase activity
EXW60_RS15630	COG0784	Response regulator, receiver
EXW60_RS15665	COG2807	transmembrane transport
EXW60_RS15680	COG4585	Histidine kinase
EXW60_RS15685	COG2197	response regulator
EXW60_RS15715	COG0420	3'-5' exonuclease activity
EXW60_RS15720	COG4717	serine-type aminopeptidase activity
EXW60_RS15725	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW60_RS15765	COG0346	lactoylglutathione lyase activity
EXW60_RS15770	COG0346	lactoylglutathione lyase activity
EXW60_RS15775	COG0457	Tetratricopeptide repeat
EXW60_RS15785	COG2267	carboxylic ester hydrolase activity
EXW60_RS15820	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW60_RS15825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW60_RS15830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW60_RS15835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW60_RS15840	COG1695	Transcriptional regulator
EXW60_RS15860	COG0693	protein deglycase activity
EXW60_RS15865	COG1595	DNA-templated transcription, initiation
EXW60_RS15885	COG3973	AAA domain
EXW60_RS15890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW60_RS15905	COG1846	Transcriptional regulator
EXW60_RS15915	COG0537	adenosine 5'-monophosphoramidase activity
EXW60_RS15920	COG1131	(ABC) transporter
EXW60_RS15925	COG4473	ABC transporter
EXW60_RS15935	COG0247	lactate metabolic process
EXW60_RS15940	COG1139	Iron-sulfur cluster binding protein
EXW60_RS15945	COG1556	Lactate utilization protein
EXW60_RS15965	COG3402	PFAM membrane-flanked domain
EXW60_RS15970	COG3428	Bacterial PH domain
EXW60_RS16010	COG3402	PFAM membrane-flanked domain
EXW60_RS16015	COG3428	Bacterial PH domain
EXW60_RS16020	COG2329	Antibiotic biosynthesis monooxygenase
EXW60_RS16025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS16030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW60_RS16035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW60_RS16040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW60_RS16060	COG1309	transcriptional regulator
EXW60_RS16065	COG1511	domain protein
EXW60_RS16095	COG1609	Transcriptional regulator
EXW60_RS16105	COG1234	tRNA 3'-trailer cleavage
EXW60_RS16110	COG0095	Lipoate-protein ligase
EXW60_RS16120	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS16135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW60_RS16145	COG4208	sulfate ABC transporter
EXW60_RS16180	COG1408	metallophosphoesterase
EXW60_RS16185	COG1078	dGTPase activity
EXW60_RS16200	COG1595	DNA-templated transcription, initiation
EXW60_RS16205	COG2207	Transcriptional regulator
EXW60_RS16205	COG3708	Transcriptional regulator
EXW60_RS16210	COG2205	protein histidine kinase activity
EXW60_RS16215	COG0745	RESPONSE REGULATOR receiver
EXW60_RS16235	COG0501	Belongs to the peptidase M48B family
EXW60_RS16240	COG0840	transmembrane signaling receptor activity
EXW60_RS16245	COG0697	spore germination
EXW60_RS16265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW60_RS16270	COG2224	Isocitrate lyase
EXW60_RS16280	COG1278	Cold shock
EXW60_RS16290	COG4903	ComK protein
EXW60_RS16300	COG0398	Pfam SNARE associated Golgi protein
EXW60_RS16310	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW60_RS16315	COG1074	ATP-dependent DNA helicase activity
EXW60_RS16365	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW60_RS16390	COG0367	asparagine synthase
EXW60_RS16400	COG0753	catalase activity
EXW60_RS16405	COG0004	ammonium transporteR
EXW60_RS16415	COG1666	GTP binding
EXW60_RS16420	COG2996	Protein conserved in bacteria
EXW60_RS16430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW60_RS16455	COG0561	phosphatase activity
EXW60_RS16475	COG2267	carboxylic ester hydrolase activity
EXW60_RS16490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW60_RS16495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW60_RS16500	COG5504	Zn-dependent protease
EXW60_RS16510	COG0180	Tryptophanyl-tRNA synthetase
EXW60_RS16520	COG4166	transmembrane transport
EXW60_RS16525	COG0601	transmembrane transport
EXW60_RS16530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW60_RS16535	COG0444	Belongs to the ABC transporter superfamily
EXW60_RS16540	COG4608	Belongs to the ABC transporter superfamily
EXW60_RS16545	COG0534	Mate efflux family protein
EXW60_RS16550	COG4166	transmembrane transport
EXW60_RS16565	COG0861	Integral membrane protein TerC family
EXW60_RS16570	COG4862	establishment of competence for transformation
EXW60_RS16575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW60_RS16585	COG1164	Oligoendopeptidase f
EXW60_RS16600	COG2346	COG2346, Truncated hemoglobins
EXW60_RS16605	COG4116	CYTH
EXW60_RS16615	COG2357	RelA SpoT domain protein
EXW60_RS16625	COG0564	pseudouridine synthase activity
EXW60_RS16635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW60_RS16640	COG0772	Belongs to the SEDS family
EXW60_RS16645	COG1216	Glycosyl transferase, family 2
EXW60_RS16665	COG0463	Glycosyl transferase, family 2
EXW60_RS16665	COG0457	Tetratricopeptide repeat
EXW60_RS16685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW60_RS16700	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW60_RS16745	COG2153	protein acetylation
EXW60_RS16750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW60_RS16755	COG2382	esterase
EXW60_RS16780	COG5492	domain, Protein
EXW60_RS16785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW60_RS16795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW60_RS16795	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW60_RS16800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW60_RS16805	COG0134	indole-3-glycerol-phosphate synthase activity
EXW60_RS16810	COG0135	phosphoribosylanthranilate isomerase activity
EXW60_RS16815	COG0133	tryptophan synthase activity
EXW60_RS16820	COG0159	tryptophan synthase activity
EXW60_RS16830	COG1620	l-lactate permease
EXW60_RS16835	COG5634	Uncharacterized conserved protein (DUF2278)
EXW60_RS16875	COG2226	methyltransferase
EXW60_RS16895	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW60_RS16900	COG0567	Dehydrogenase, E1 component
EXW60_RS16905	COG1476	TRANSCRIPTIONal
EXW60_RS16930	COG4152	abc transporter atp-binding protein
EXW60_RS16935	COG1668	transmembrane transport
EXW60_RS16955	COG1686	Belongs to the peptidase S11 family
EXW60_RS16960	COG0681	Belongs to the peptidase S26 family
EXW60_RS16995	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS17005	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW60_RS17010	COG1177	transmembrane transport
EXW60_RS17015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW60_RS17025	COG2409	Drug exporters of the RND superfamily
EXW60_RS17035	COG0564	pseudouridine synthase activity
EXW60_RS17045	COG2340	Cysteine-rich secretory protein family
EXW60_RS17050	COG0247	lactate metabolic process
EXW60_RS17055	COG0277	FAD linked oxidase domain protein
EXW60_RS17060	COG3835	regulator
EXW60_RS17070	COG0745	RESPONSE REGULATOR receiver
EXW60_RS17075	COG3850	Histidine kinase
EXW60_RS17075	COG5002	protein histidine kinase activity
EXW60_RS17080	COG2186	Transcriptional regulator
EXW60_RS17085	COG0247	lactate metabolic process
EXW60_RS17090	COG1139	Iron-sulfur cluster binding protein
EXW60_RS17095	COG1556	Lactate utilization protein
EXW60_RS17100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW60_RS17110	COG2116	formate transmembrane transporter activity
EXW60_RS17115	COG0861	Integral membrane protein TerC family
EXW60_RS17120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW60_RS17130	COG2030	dehydratase
EXW60_RS17150	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS17155	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW60_RS17165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW60_RS17180	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW60_RS17185	COG3842	ATPase activity
EXW60_RS17195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW60_RS17200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW60_RS17210	COG1349	DNA-binding transcription factor activity
EXW60_RS17220	COG0235	Class ii aldolase
EXW60_RS17230	COG2861	carbohydrate metabolic process
EXW60_RS17240	COG3852	Histidine kinase
EXW60_RS17245	COG1846	Transcriptional regulator
EXW60_RS17255	COG2318	DinB family
EXW60_RS17260	COG5002	protein histidine kinase activity
EXW60_RS17265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW60_RS17270	COG0720	synthase
EXW60_RS17280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW60_RS17285	COG4873	Protein conserved in bacteria
EXW60_RS17300	COG0456	acetyltransferase
EXW60_RS17315	COG1780	Probably involved in ribonucleotide reductase function
EXW60_RS17330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW60_RS17335	COG0531	amino acid
EXW60_RS17340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW60_RS17355	COG2204	response regulator
EXW60_RS17360	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS17370	COG1725	Transcriptional regulator
EXW60_RS17375	COG1131	(ABC) transporter
EXW60_RS17385	COG1131	(ABC) transporter
EXW60_RS17390	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW60_RS17405	COG1522	sequence-specific DNA binding
EXW60_RS17415	COG1335	isochorismatase
EXW60_RS17425	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW60_RS17430	COG2070	2-Nitropropane dioxygenase
EXW60_RS17435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW60_RS17440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW60_RS17445	COG1696	Membrane protein involved in D-alanine export
EXW60_RS17450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW60_RS17470	COG0716	FMN binding
EXW60_RS17505	COG0534	Mate efflux family protein
EXW60_RS17525	COG1846	Transcriptional regulator
EXW60_RS17540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW60_RS17550	COG3874	Sporulation protein YtfJ
EXW60_RS17570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW60_RS17575	COG0028	Belongs to the TPP enzyme family
EXW60_RS17580	COG0440	acetolactate synthase activity
EXW60_RS17590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW60_RS17600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW60_RS17610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW60_RS17615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW60_RS17625	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW60_RS17630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW60_RS17635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW60_RS17640	COG0107	imidazoleglycerol-phosphate synthase activity
EXW60_RS17650	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW60_RS17655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW60_RS17670	COG1183	phosphatidylcholine synthase activity
EXW60_RS17675	COG1368	sulfuric ester hydrolase activity
EXW60_RS17685	COG0019	diaminopimelate decarboxylase activity
EXW60_RS17695	COG0175	sulfate reduction
EXW60_RS17700	COG2046	Belongs to the sulfate adenylyltransferase family
EXW60_RS17705	COG0529	Catalyzes the synthesis of activated sulfate
EXW60_RS17710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW60_RS17730	COG1648	precorrin-2 dehydrogenase activity
EXW60_RS17735	COG0733	neurotransmitter:sodium symporter activity
EXW60_RS17760	COG1757	Na H antiporter
EXW60_RS17780	COG4758	membrane
EXW60_RS17785	COG4585	Histidine kinase
EXW60_RS17790	COG2197	response regulator
EXW60_RS17800	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS17810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW60_RS17850	COG0730	response to heat
EXW60_RS17855	COG0306	phosphate transporter
EXW60_RS17860	COG1392	Phosphate transport regulator
EXW60_RS17865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS17880	COG3852	Histidine kinase
EXW60_RS17885	COG1801	Protein of unknown function DUF72
EXW60_RS17895	COG0582	viral genome integration into host DNA
EXW60_RS17900	COG5002	protein histidine kinase activity
EXW60_RS17915	COG0392	lysyltransferase activity
EXW60_RS17915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW60_RS17930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW60_RS17935	COG1686	Belongs to the peptidase S11 family
EXW60_RS17940	COG2715	membrane protein required for spore maturation
EXW60_RS17945	COG0700	Nucleoside recognition
EXW60_RS17950	COG1187	pseudouridine synthase activity
EXW60_RS17960	COG1333	cytochrome c biogenesis protein
EXW60_RS17965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW60_RS17970	COG0745	RESPONSE REGULATOR receiver
EXW60_RS17975	COG5002	protein histidine kinase activity
EXW60_RS17980	COG2096	Adenosyltransferase
EXW60_RS17985	COG4942	peptidase
EXW60_RS17995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW60_RS18000	COG1141	Ferredoxin
EXW60_RS18005	COG4955	Helix-turn-helix domain
EXW60_RS18010	COG0514	ATP-dependent DNA helicase (RecQ)
EXW60_RS18015	COG1266	CAAX protease self-immunity
EXW60_RS18025	COG1408	metallophosphoesterase
EXW60_RS18040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW60_RS18060	COG0492	ferredoxin-NADP+ reductase activity
EXW60_RS18065	COG0252	asparaginase activity
EXW60_RS18075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW60_RS18085	COG1304	FMN binding
EXW60_RS18115	COG1160	GTP binding
EXW60_RS18120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW60_RS18140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW60_RS18150	COG0302	gtp cyclohydrolase
EXW60_RS18155	COG0142	geranyltranstransferase activity
EXW60_RS18160	COG2226	methyltransferase
EXW60_RS18165	COG0142	geranyltranstransferase activity
EXW60_RS18180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW60_RS18190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW60_RS18195	COG0457	Tetratricopeptide repeat
EXW60_RS18200	COG5582	Belongs to the UPF0302 family
EXW60_RS18215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW60_RS18230	COG4347	Protein of unknown function (DUF1405)
EXW60_RS18245	COG2738	Putative neutral zinc metallopeptidase
EXW60_RS18255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS18260	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW60_RS18265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW60_RS18270	COG1803	Methylglyoxal synthase
EXW60_RS18275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW60_RS18280	COG0438	transferase activity, transferring glycosyl groups
EXW60_RS18285	COG0617	tRNA 3'-terminal CCA addition
EXW60_RS18295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW60_RS18300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW60_RS18310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW60_RS18310	COG1199	ATP-dependent helicase activity
EXW60_RS18330	COG3935	DnaD domain protein
EXW60_RS18335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW60_RS18345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS18345	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW60_RS18350	COG3331	DNA recombination
EXW60_RS18385	COG4474	Belongs to the UPF0398 family
EXW60_RS18390	COG3599	regulation of cell shape
EXW60_RS18400	COG0116	Belongs to the methyltransferase superfamily
EXW60_RS18410	COG1199	ATP-dependent helicase activity
EXW60_RS18415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW60_RS18425	COG0024	Methionine aminopeptidase
EXW60_RS18435	COG2233	PERMEase
EXW60_RS18440	COG2311	Membrane
EXW60_RS18450	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW60_RS18460	COG0456	acetyltransferase
EXW60_RS18470	COG2897	thiosulfate sulfurtransferase activity
EXW60_RS18510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW60_RS18550	COG1215	transferase activity, transferring glycosyl groups
EXW60_RS18555	COG0438	transferase activity, transferring glycosyl groups
EXW60_RS18570	COG0454	-acetyltransferase
EXW60_RS18590	COG0328	RNA-DNA hybrid ribonuclease activity
EXW60_RS18625	COG3403	YqcI/YcgG family
EXW60_RS18630	COG1280	lysine exporter protein (LysE YggA)
EXW60_RS18645	COG3162	membrane
EXW60_RS18655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW60_RS18665	COG0475	glutathione-regulated potassium exporter activity
EXW60_RS18670	COG0789	Transcriptional regulator
EXW60_RS18670	COG4978	Transcriptional regulator
EXW60_RS18680	COG2323	membrane
EXW60_RS18685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW60_RS18730	COG1923	regulation of RNA biosynthetic process
EXW60_RS18740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW60_RS18745	COG1360	Flagellar Motor Protein
EXW60_RS18750	COG2201	protein-glutamate methylesterase activity
EXW60_RS18755	COG0643	Histidine kinase
EXW60_RS18755	COG2198	Histidine kinase
EXW60_RS18760	COG1776	CheC inhibitor of MCP methylation
EXW60_RS18760	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW60_RS18775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW60_RS18795	COG1256	bacterial-type flagellum assembly
EXW60_RS18800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW60_RS18820	COG1815	bacterial-type flagellum-dependent cell motility
EXW60_RS18825	COG1558	bacterial-type flagellum-dependent cell motility
EXW60_RS18835	COG1766	The M ring may be actively involved in energy transduction
EXW60_RS18840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW60_RS18850	COG1157	protein secretion by the type III secretion system
EXW60_RS18870	COG1749	Flagellar hook protein flgE
EXW60_RS18885	COG0784	Response regulator, receiver
EXW60_RS18885	COG0835	chemotaxis
EXW60_RS18905	COG0861	Integral membrane protein TerC family
EXW60_RS18915	COG3383	formate dehydrogenase (NAD+) activity
EXW60_RS18920	COG2427	Protein of unknown function (DUF1641)
EXW60_RS18925	COG5609	conserved protein (DUF2294)
EXW60_RS18930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW60_RS18940	COG2116	formate transmembrane transporter activity
EXW60_RS18945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW60_RS18950	COG0303	'Molybdopterin
EXW60_RS18955	COG0314	molybdopterin synthase activity
EXW60_RS18960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW60_RS18970	COG0489	protein tyrosine kinase activity
EXW60_RS18975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW60_RS18980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW60_RS18985	COG0741	lytic transglycosylase activity
EXW60_RS18995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW60_RS19000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW60_RS19000	COG1776	CheC inhibitor of MCP methylation
EXW60_RS19010	COG1338	Plays a role in the flagellum-specific transport system
EXW60_RS19015	COG1987	bacterial-type flagellum assembly
EXW60_RS19025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW60_RS19030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW60_RS19035	COG1419	protein localization to endoplasmic reticulum
EXW60_RS19040	COG4786	Flagellar basal body rod
EXW60_RS19045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW60_RS19085	COG2329	Antibiotic biosynthesis monooxygenase
EXW60_RS19100	COG2814	Major facilitator Superfamily
EXW60_RS19110	COG0583	DNA-binding transcription factor activity
EXW60_RS19115	COG3842	ATPase activity
EXW60_RS19165	COG0406	alpha-ribazole phosphatase activity
EXW60_RS19195	COG0367	asparagine synthase
EXW60_RS19225	COG1802	Transcriptional regulator
EXW60_RS19230	COG0697	spore germination
EXW60_RS19245	COG0438	transferase activity, transferring glycosyl groups
EXW60_RS19245	COG1216	Glycosyl transferase, family 2
EXW60_RS19250	COG1757	Na H antiporter
EXW60_RS19270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS19285	COG0534	Mate efflux family protein
EXW60_RS19290	COG3340	Belongs to the peptidase S51 family
EXW60_RS19310	COG0785	Cytochrome C biogenesis protein
EXW60_RS19315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS19330	COG3048	D-serine ammonia-lyase activity
EXW60_RS19335	COG2733	membrane
EXW60_RS19370	COG1131	(ABC) transporter
EXW60_RS19385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW60_RS19390	COG0528	UMP kinase activity
EXW60_RS19400	COG1027	Aspartate ammonia-lyase
EXW60_RS19405	COG0281	malic enzyme
EXW60_RS19410	COG4191	Histidine kinase
EXW60_RS19415	COG0784	Response regulator, receiver
EXW60_RS19420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW60_RS19430	COG2502	aspartate--ammonia ligase
EXW60_RS19435	COG3620	sequence-specific DNA binding
EXW60_RS19465	COG1051	belongs to the nudix hydrolase family
EXW60_RS19470	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS19480	COG2814	Major facilitator Superfamily
EXW60_RS19505	COG1695	Transcriptional regulator
EXW60_RS19520	COG0477	Major facilitator Superfamily
EXW60_RS19535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW60_RS19540	COG2223	nitrite transmembrane transporter activity
EXW60_RS19545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW60_RS19560	COG2244	polysaccharide biosynthetic process
EXW60_RS19565	COG0733	neurotransmitter:sodium symporter activity
EXW60_RS19575	COG5566	PFAM Mor transcription activator
EXW60_RS19580	COG2323	membrane
EXW60_RS19600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW60_RS19605	COG2132	Multicopper oxidase
EXW60_RS19615	COG5002	protein histidine kinase activity
EXW60_RS19620	COG0745	RESPONSE REGULATOR receiver
EXW60_RS19630	COG0129	dihydroxy-acid dehydratase activity
EXW60_RS19635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW60_RS19660	COG2814	Major facilitator Superfamily
EXW60_RS19665	COG3384	dioxygenase
EXW60_RS19710	COG4166	transmembrane transport
EXW60_RS19715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS19735	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW60_RS19740	COG1054	Belongs to the UPF0176 family
EXW60_RS19750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW60_RS19755	COG0531	amino acid
EXW60_RS19780	COG2390	Transcriptional regulator
EXW60_RS19790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW60_RS19795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS19800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW60_RS19805	COG0295	cytidine deaminase activity
EXW60_RS19815	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW60_RS19835	COG0583	DNA-binding transcription factor activity
EXW60_RS19855	COG2132	Multicopper oxidase
EXW60_RS19865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW60_RS19875	COG0583	DNA-binding transcription factor activity
EXW60_RS19895	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS19915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS19925	COG1276	copper resistance
EXW60_RS19925	COG2372	response to copper ion
EXW60_RS19930	COG4549	nuclear export factor GLE1
EXW60_RS19940	COG0697	spore germination
EXW60_RS19945	COG0583	DNA-binding transcription factor activity
EXW60_RS19950	COG1959	2 iron, 2 sulfur cluster binding
EXW60_RS19955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW60_RS19960	COG0778	Nitroreductase
EXW60_RS19970	COG0628	permease
EXW60_RS19985	COG1231	oxidoreductase activity
EXW60_RS19990	COG0523	cobalamin synthesis protein
EXW60_RS20000	COG0411	ABC transporter
EXW60_RS20020	COG0583	DNA-binding transcription factor activity
EXW60_RS20030	COG1942	4-Oxalocrotonate Tautomerase
EXW60_RS20045	COG0346	lactoylglutathione lyase activity
EXW60_RS20055	COG1271	oxidase subunit
EXW60_RS20060	COG1294	oxidase, subunit
EXW60_RS20065	COG4988	ABC transporter
EXW60_RS20070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW60_RS20100	COG1686	Belongs to the peptidase S11 family
EXW60_RS20115	COG1388	LysM domain
EXW60_RS20115	COG0791	NLP P60 protein
EXW60_RS20125	COG1132	(ABC) transporter
EXW60_RS20130	COG0745	RESPONSE REGULATOR receiver
EXW60_RS20135	COG5002	protein histidine kinase activity
EXW60_RS20140	COG0300	oxidoreductase activity
EXW60_RS20145	COG4122	O-methyltransferase activity
EXW60_RS20175	COG0460	homoserine dehydrogenase
EXW60_RS20185	COG0083	homoserine kinase activity
EXW60_RS20200	COG1316	TRANSCRIPTIONal
EXW60_RS20215	COG1285	pathogenesis
EXW60_RS20220	COG1247	-acetyltransferase
EXW60_RS20240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW60_RS20250	COG1082	Xylose isomerase domain protein TIM barrel
EXW60_RS20260	COG2814	Major facilitator Superfamily
EXW60_RS20265	COG1279	arginine transmembrane transporter activity
EXW60_RS20270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS20280	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW60_RS20310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW60_RS20315	COG0577	efflux transmembrane transporter activity
EXW60_RS20320	COG2002	toxin-antitoxin pair type II binding
EXW60_RS20325	COG1404	Belongs to the peptidase S8 family
EXW60_RS20330	COG0640	Transcriptional regulator
EXW60_RS20335	COG0667	Aldo Keto reductase
EXW60_RS20340	COG2814	Major facilitator Superfamily
EXW60_RS20380	COG3949	Membrane
EXW60_RS20385	COG0783	Belongs to the Dps family
EXW60_RS20400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW60_RS20410	COG1231	oxidoreductase activity
EXW60_RS20415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS20420	COG4989	oxidoreductase activity
EXW60_RS20425	COG0523	cobalamin synthesis protein
EXW60_RS20430	COG0456	acetyltransferase
EXW60_RS20435	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW60_RS20450	COG2814	Major facilitator Superfamily
EXW60_RS20455	COG1136	(ABC) transporter
EXW60_RS20460	COG0577	efflux transmembrane transporter activity
EXW60_RS20475	COG1902	pentaerythritol trinitrate reductase activity
EXW60_RS20480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW60_RS20490	COG4166	transmembrane transport
EXW60_RS20495	COG0346	lactoylglutathione lyase activity
EXW60_RS20505	COG0406	alpha-ribazole phosphatase activity
EXW60_RS20515	COG5337	Spore coat protein CotH
EXW60_RS20520	COG1051	belongs to the nudix hydrolase family
EXW60_RS20525	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS20530	COG2244	polysaccharide biosynthetic process
EXW60_RS20540	COG0701	Predicted permease
EXW60_RS20545	COG3689	TIGRFAM TIGR03943 family protein
EXW60_RS20550	COG1607	acyl-coa hydrolase
EXW60_RS20560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW60_RS20575	COG0702	epimerase
EXW60_RS20580	COG2839	Protein conserved in bacteria
EXW60_RS20585	COG1253	flavin adenine dinucleotide binding
EXW60_RS20610	COG1114	Component of the transport system for branched-chain amino acids
EXW60_RS20615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW60_RS20630	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS20640	COG1876	peptidase activity
EXW60_RS20645	COG0494	nUDIX hydrolase
EXW60_RS20665	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS20675	COG0561	phosphatase activity
EXW60_RS20680	COG1846	Transcriptional regulator
EXW60_RS20685	COG2814	Major facilitator Superfamily
EXW60_RS20695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW60_RS20700	COG4106	trans-aconitate 2-methyltransferase activity
EXW60_RS20715	COG1819	glycosyl
EXW60_RS20720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS20725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS20750	COG0456	acetyltransferase
EXW60_RS20790	COG4974	Belongs to the 'phage' integrase family
EXW60_RS20890	COG3874	Sporulation protein YtfJ
EXW60_RS20915	COG2226	methyltransferase
EXW60_RS20945	COG0604	alcohol dehydrogenase
EXW60_RS20950	COG1595	DNA-templated transcription, initiation
EXW60_RS20970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW60_RS20970	COG0426	domain, Protein
EXW60_RS20980	COG0386	Belongs to the glutathione peroxidase family
EXW60_RS20985	COG1305	Transglutaminase-like
EXW60_RS20990	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW60_RS20995	COG0714	Associated with various cellular activities
EXW60_RS21000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW60_RS21005	COG1140	nitrate reductase beta subunit
EXW60_RS21010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW60_RS21015	COG2181	nitrate reductase activity
EXW60_RS21020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW60_RS21025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW60_RS21030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW60_RS21035	COG0303	'Molybdopterin
EXW60_RS21040	COG0314	molybdopterin synthase activity
EXW60_RS21050	COG2223	nitrite transmembrane transporter activity
EXW60_RS21070	COG1648	precorrin-2 dehydrogenase activity
EXW60_RS21080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW60_RS21080	COG1587	Uroporphyrinogen-III synthase
EXW60_RS21085	COG2146	nitrite reductase [NAD(P)H] activity
EXW60_RS21090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW60_RS21095	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW60_RS21125	COG2359	stage V sporulation protein S
EXW60_RS21135	COG1418	mRNA catabolic process
EXW60_RS21140	COG0488	(ABC) transporter
EXW60_RS21170	COG1413	lyase activity
EXW60_RS21185	COG2136	Putative SAM-dependent methyltransferase
EXW60_RS21185	COG2521	methyltransferase
EXW60_RS21190	COG0018	arginyl-trna synthetase
EXW60_RS21240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW60_RS21245	COG0017	Asparaginyl-tRNA synthetase
EXW60_RS21250	COG0733	neurotransmitter:sodium symporter activity
EXW60_RS21275	COG2610	gluconate transmembrane transporter activity
EXW60_RS21285	COG1794	racemase activity, acting on amino acids and derivatives
EXW60_RS21295	COG0456	acetyltransferase
EXW60_RS21300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW60_RS21305	COG1131	(ABC) transporter
EXW60_RS21310	COG4473	ABC transporter
EXW60_RS21320	COG0546	phosphoglycolate phosphatase activity
EXW60_RS21360	COG0768	penicillin binding
EXW60_RS21375	COG1272	protein, Hemolysin III
EXW60_RS21380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW60_RS21385	COG0805	protein transport
EXW60_RS21395	COG1307	EDD domain protein, DegV family
EXW60_RS21400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW60_RS21405	COG1999	signal sequence binding
EXW60_RS21410	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW60_RS21415	COG0367	asparagine synthase
EXW60_RS21430	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW60_RS21435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW60_RS21440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW60_RS21460	COG1335	isochorismatase
EXW60_RS21470	COG0668	transmembrane transport
EXW60_RS21475	COG4585	Histidine kinase
EXW60_RS21475	COG2203	Gaf domain
EXW60_RS21480	COG2197	response regulator
EXW60_RS21485	COG1737	Transcriptional regulator
EXW60_RS21490	COG1064	alcohol dehydrogenase
EXW60_RS21510	COG1070	Carbohydrate kinase
EXW60_RS21520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW60_RS21540	COG0517	IMP dehydrogenase activity
EXW60_RS21540	COG1125	glycine betaine transport
EXW60_RS21545	COG1174	glycine betaine transport
EXW60_RS21580	COG1253	flavin adenine dinucleotide binding
EXW60_RS21585	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS21590	COG5506	Protein of unknown function (DUF1694)
EXW60_RS21605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW60_RS21610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW60_RS21615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW60_RS21620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW60_RS21625	COG0456	acetyltransferase
EXW60_RS21630	COG3829	transcription factor binding
EXW60_RS21635	COG1509	lysine 2,3-aminomutase activity
EXW60_RS21645	COG4479	Belongs to the UPF0346 family
EXW60_RS21670	COG0515	serine threonine protein kinase
EXW60_RS21670	COG3064	Membrane
EXW60_RS21670	COG4991	sh3 domain protein
EXW60_RS21680	COG0671	phosphoesterase, PA-phosphatase related
EXW60_RS21685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW60_RS21690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW60_RS21760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW60_RS21785	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS21805	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW60_RS21805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS21815	COG2814	Major facilitator Superfamily
EXW60_RS21825	COG0372	Belongs to the citrate synthase family
EXW60_RS21830	COG2079	MmgE PrpD family protein
EXW60_RS21835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW60_RS21840	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS21845	COG2084	Dehydrogenase
EXW60_RS21850	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS21855	COG1280	lysine exporter protein (LysE YggA)
EXW60_RS21860	COG1024	Enoyl-CoA hydratase
EXW60_RS21875	COG0420	3'-5' exonuclease activity
EXW60_RS21900	COG2223	nitrite transmembrane transporter activity
EXW60_RS21905	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS21910	COG1169	isochorismate synthase
EXW60_RS21915	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW60_RS21920	COG3433	isochorismatase activity
EXW60_RS21920	COG1535	isochorismatase
EXW60_RS21925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW60_RS21930	COG3251	PFAM MbtH domain protein
EXW60_RS21935	COG2814	Major facilitator Superfamily
EXW60_RS21950	COG0776	regulation of translation
EXW60_RS21960	COG2318	DinB family
EXW60_RS21965	COG1115	amino acid carrier protein
EXW60_RS21980	COG2329	Antibiotic biosynthesis monooxygenase
EXW60_RS21990	COG1187	pseudouridine synthase activity
EXW60_RS21995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW60_RS22000	COG3655	Transcriptional regulator
EXW60_RS22010	COG1136	(ABC) transporter
EXW60_RS22020	COG2814	Major facilitator Superfamily
EXW60_RS22035	COG0028	Belongs to the TPP enzyme family
EXW60_RS22055	COG1253	flavin adenine dinucleotide binding
EXW60_RS22090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW60_RS22110	COG1846	Transcriptional regulator
EXW60_RS22120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS22125	COG1309	transcriptional regulator
EXW60_RS22155	COG1247	-acetyltransferase
EXW60_RS22170	COG1132	(ABC) transporter
EXW60_RS22180	COG1309	transcriptional regulator
EXW60_RS22185	COG2357	RelA SpoT domain protein
EXW60_RS22190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS22220	COG0596	Alpha beta hydrolase
EXW60_RS22225	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW60_RS22235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS22265	COG0583	DNA-binding transcription factor activity
EXW60_RS22270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW60_RS22320	COG0583	DNA-binding transcription factor activity
EXW60_RS22325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW60_RS22330	COG2258	MOSC domain
EXW60_RS22345	COG1132	(ABC) transporter
EXW60_RS22350	COG1132	(ABC) transporter
EXW60_RS22360	COG1396	sequence-specific DNA binding
EXW60_RS22385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW60_RS22395	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW60_RS22400	COG1595	DNA-templated transcription, initiation
EXW60_RS22425	COG1649	PFAM Uncharacterised BCR, COG1649
EXW60_RS22445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW60_RS22450	COG2971	BadF BadG BcrA BcrD
EXW60_RS22500	COG1309	transcriptional regulator
EXW60_RS22515	COG1136	(ABC) transporter
EXW60_RS22515	COG0577	efflux transmembrane transporter activity
EXW60_RS22520	COG0500	methyltransferase
EXW60_RS22520	COG3615	Tellurite resistance protein tehB
EXW60_RS22535	COG0588	phosphoglycerate mutase activity
EXW60_RS22560	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW60_RS22570	COG0110	maltose O-acetyltransferase activity
EXW60_RS22575	COG1136	(ABC) transporter
EXW60_RS22600	COG1686	Belongs to the peptidase S11 family
EXW60_RS22625	COG0768	penicillin binding
EXW60_RS22630	COG0745	RESPONSE REGULATOR receiver
EXW60_RS22635	COG2205	protein histidine kinase activity
EXW60_RS22640	COG1136	(ABC) transporter
EXW60_RS22645	COG0577	efflux transmembrane transporter activity
EXW60_RS22655	COG1595	DNA-templated transcription, initiation
EXW60_RS22665	COG0768	penicillin binding
EXW60_RS22670	COG0768	penicillin binding
EXW60_RS22705	COG1252	NADH dehydrogenase
EXW60_RS22710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS22710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS22755	COG3397	chitin binding
EXW60_RS22760	COG0823	Involved in the tonB-independent uptake of proteins
EXW60_RS22770	COG1408	metallophosphoesterase
EXW60_RS22780	COG1131	(ABC) transporter
EXW60_RS22790	COG1309	transcriptional regulator
EXW60_RS22800	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS22805	COG0439	Biotin carboxylase
EXW60_RS22810	COG0511	ligase activity, forming carbon-carbon bonds
EXW60_RS22815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW60_RS22820	COG1024	Enoyl-CoA hydratase
EXW60_RS22825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW60_RS22830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW60_RS22875	COG0572	uridine kinase
EXW60_RS22910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW60_RS22940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW60_RS22965	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS22970	COG1733	regulation of RNA biosynthetic process
EXW60_RS22995	COG1309	transcriptional regulator
EXW60_RS23025	COG0697	spore germination
EXW60_RS23030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS23060	COG2323	membrane
EXW60_RS23065	COG2132	Multicopper oxidase
EXW60_RS23080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS23085	COG0697	spore germination
EXW60_RS23090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW60_RS23095	COG0201	protein transport
EXW60_RS23105	COG0737	Belongs to the 5'-nucleotidase family
EXW60_RS23110	COG3227	Zinc metalloprotease (Elastase)
EXW60_RS23115	COG1523	belongs to the glycosyl hydrolase 13 family
EXW60_RS23130	COG0076	glutamate decarboxylase activity
EXW60_RS23135	COG0657	acetylesterase activity
EXW60_RS23150	COG0577	efflux transmembrane transporter activity
EXW60_RS23155	COG1136	(ABC) transporter
EXW60_RS23175	COG0745	RESPONSE REGULATOR receiver
EXW60_RS23205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW60_RS23210	COG1183	phosphatidylcholine synthase activity
EXW60_RS23220	COG1132	(ABC) transporter
EXW60_RS23225	COG3961	Belongs to the TPP enzyme family
EXW60_RS23245	COG0322	excinuclease ABC activity
EXW60_RS23270	COG2318	DinB family
EXW60_RS23285	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW60_RS23335	COG0592	DNA-directed DNA polymerase activity
EXW60_RS23340	COG2816	NAD+ diphosphatase activity
EXW60_RS23350	COG2223	nitrite transmembrane transporter activity
EXW60_RS23360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS23370	COG0494	nUDIX hydrolase
EXW60_RS23390	COG0697	spore germination
EXW60_RS23395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS23420	COG1733	regulation of RNA biosynthetic process
EXW60_RS23440	COG1132	(ABC) transporter
EXW60_RS23440	COG2375	cellular response to nickel ion
EXW60_RS23445	COG1132	(ABC) transporter
EXW60_RS23475	COG0768	penicillin binding
EXW60_RS23480	COG0671	phosphoesterase, PA-phosphatase related
EXW60_RS23485	COG0604	alcohol dehydrogenase
EXW60_RS23490	COG5002	protein histidine kinase activity
EXW60_RS23495	COG0745	RESPONSE REGULATOR receiver
EXW60_RS23530	COG1122	ATPase activity
EXW60_RS23535	COG4720	Psort location CytoplasmicMembrane, score
EXW60_RS23555	COG0768	penicillin binding
EXW60_RS23565	COG0561	phosphatase activity
EXW60_RS23610	COG2124	cytochrome p450
EXW60_RS23655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW60_RS23665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS23670	COG0460	homoserine dehydrogenase
EXW60_RS23690	COG0577	efflux transmembrane transporter activity
EXW60_RS23695	COG1136	(ABC) transporter
EXW60_RS23710	COG0488	(ABC) transporter
EXW60_RS23715	COG0667	Aldo Keto reductase
EXW60_RS23720	COG0583	DNA-binding transcription factor activity
EXW60_RS23735	COG2205	protein histidine kinase activity
EXW60_RS23740	COG0745	RESPONSE REGULATOR receiver
EXW60_RS23750	COG3773	Cell wall hydrolase
EXW60_RS23755	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW60_RS23765	COG3386	PFAM SMP-30 Gluconolaconase
EXW60_RS23775	COG0604	alcohol dehydrogenase
EXW60_RS23825	COG2959	enzyme of heme biosynthesis
EXW60_RS23850	COG3483	tryptophan 2,3-dioxygenase activity
EXW60_RS23855	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW60_RS23860	COG3844	kynureninase activity
EXW60_RS23865	COG1309	transcriptional regulator
EXW60_RS23880	COG3284	Transcriptional regulator
EXW60_RS23895	COG1349	DNA-binding transcription factor activity
EXW60_RS23915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW60_RS23920	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW60_RS23925	COG0022	dehydrogenase e1 component
EXW60_RS23930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW60_RS23940	COG2223	nitrite transmembrane transporter activity
EXW60_RS23950	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS23955	COG0456	acetyltransferase
EXW60_RS23955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW60_RS23990	COG4176	ABC-type proline glycine betaine transport system permease component
EXW60_RS23995	COG4175	Glycine betaine
EXW60_RS23995	COG0517	IMP dehydrogenase activity
EXW60_RS24020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW60_RS24025	COG2153	protein acetylation
EXW60_RS24030	COG3397	chitin binding
EXW60_RS24040	COG1819	glycosyl
EXW60_RS24055	COG2205	protein histidine kinase activity
EXW60_RS24060	COG2315	Protein conserved in bacteria
EXW60_RS24105	COG3973	AAA domain
EXW60_RS24115	COG2105	PFAM AIG2 family protein
EXW60_RS24120	COG0514	ATP-dependent DNA helicase (RecQ)
EXW60_RS24145	COG4637	Psort location Cytoplasmic, score
EXW60_RS24155	COG1227	inorganic diphosphatase activity
EXW60_RS24160	COG3397	chitin binding
EXW60_RS24170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW60_RS24175	COG1115	amino acid carrier protein
EXW60_RS24180	COG1012	belongs to the aldehyde dehydrogenase family
EXW60_RS24185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW60_RS24195	COG3938	Belongs to the proline racemase family
EXW60_RS24200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW60_RS24240	COG0586	Pfam SNARE associated Golgi protein
EXW60_RS24255	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW60_RS24260	COG4166	transmembrane transport
EXW60_RS24270	COG4948	Mandelate Racemase Muconate Lactonizing
EXW60_RS24290	COG0667	Aldo Keto reductase
EXW60_RS24335	COG2936	dipeptidyl-peptidase activity
EXW60_RS24345	COG0745	RESPONSE REGULATOR receiver
EXW60_RS24365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW60_RS24400	COG1307	EDD domain protein, DegV family
EXW60_RS24455	COG2814	Major facilitator Superfamily
EXW60_RS24465	COG1664	Polymer-forming cytoskeletal
EXW60_RS24470	COG0789	Transcriptional regulator
EXW60_RS24475	COG4533	DNA binding
EXW60_RS24480	COG0477	Major facilitator Superfamily
EXW60_RS24480	COG2814	Major facilitator Superfamily
EXW60_RS24500	COG2261	transglycosylase associated protein
EXW60_RS24515	COG2226	methyltransferase
EXW60_RS24550	COG0436	Aminotransferase
EXW60_RS24555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW60_RS24580	COG1131	(ABC) transporter
EXW60_RS24585	COG2188	Transcriptional regulator
EXW60_RS24625	COG0628	permease
EXW60_RS24670	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW60_RS24680	COG0697	spore germination
EXW60_RS24685	COG2318	DinB family
EXW60_RS24735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW60_RS24745	COG2814	Major facilitator Superfamily
EXW60_RS24765	COG0488	(ABC) transporter
EXW60_RS24770	COG2409	Drug exporters of the RND superfamily
EXW60_RS24770	COG1033	growth of symbiont in host cell
EXW60_RS24775	COG1309	transcriptional regulator
EXW60_RS24795	COG0287	Prephenate dehydrogenase
EXW60_RS24810	COG1605	Chorismate mutase
EXW60_RS24810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW60_RS24835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW60_RS24860	COG0346	lactoylglutathione lyase activity
EXW60_RS24870	COG0431	NADPH-dependent FMN reductase
EXW60_RS24900	COG0579	oxidoreductase
EXW60_RS24905	COG1879	ABC-type sugar transport system periplasmic component
EXW60_RS24915	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW60_RS24920	COG1129	ABC transporter
EXW60_RS24925	COG2390	Transcriptional regulator
EXW60_RS24945	COG2226	methyltransferase
EXW60_RS24960	COG0346	lactoylglutathione lyase activity
EXW60_RS24965	COG2329	Antibiotic biosynthesis monooxygenase
EXW60_RS24985	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW60_RS24995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW60_RS25000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW60_RS25005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW60_RS25010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW60_RS25015	COG3239	Fatty acid desaturase
EXW60_RS25035	COG3655	Transcriptional regulator
EXW60_RS25080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS25085	COG0346	lactoylglutathione lyase activity
EXW60_RS25105	COG0714	Associated with various cellular activities
EXW60_RS25125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW60_RS25130	COG0753	catalase activity
EXW60_RS25150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW60_RS25170	COG0778	Nitroreductase
EXW60_RS25175	COG1846	Transcriptional regulator
EXW60_RS25190	COG1051	belongs to the nudix hydrolase family
EXW60_RS25195	COG3831	ATPase activity
EXW60_RS25195	COG4884	unkown
EXW60_RS25215	COG2207	Transcriptional regulator
EXW60_RS25220	COG0456	acetyltransferase
EXW60_RS25240	COG0697	spore germination
EXW60_RS25245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW60_RS25255	COG1671	Belongs to the UPF0178 family
EXW60_RS25275	COG0596	Alpha beta hydrolase
EXW60_RS25285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW60_RS25285	COG0456	acetyltransferase
EXW60_RS25310	COG0730	response to heat
EXW60_RS25320	COG0833	amino acid
EXW60_RS25330	COG4335	DNA alkylation repair
EXW60_RS25355	COG0681	Belongs to the peptidase S26 family
EXW60_RS25360	COG0768	penicillin binding
EXW60_RS25370	COG3104	oligopeptide transport
EXW60_RS25375	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW60_RS25390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW60_RS25395	COG1984	allophanate hydrolase subunit 2
EXW60_RS25400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW60_RS25405	COG1414	Transcriptional regulator
EXW60_RS25435	COG1960	acyl-CoA dehydrogenase activity
EXW60_RS25450	COG0346	lactoylglutathione lyase activity
EXW60_RS25460	COG0640	Transcriptional regulator
EXW60_RS25465	COG3314	Sporulation integral membrane protein YlbJ
EXW60_RS25485	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW60_RS25500	COG0574	Belongs to the PEP-utilizing enzyme family
EXW60_RS25500	COG3848	Pyruvate phosphate dikinase
EXW60_RS25510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW60_RS25515	COG1876	peptidase activity
EXW60_RS25525	COG5002	protein histidine kinase activity
EXW60_RS25530	COG0745	RESPONSE REGULATOR receiver
EXW60_RS25535	COG4990	cell redox homeostasis
EXW60_RS25560	COG5002	protein histidine kinase activity
EXW60_RS25565	COG0745	RESPONSE REGULATOR receiver
EXW60_RS25575	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW60_RS25590	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW60_RS25595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW60_RS25600	COG1121	(ABC) transporter
EXW60_RS25625	COG3320	Male sterility
EXW60_RS25625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW60_RS25630	COG1309	transcriptional regulator
EXW60_RS25635	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS25640	COG1522	sequence-specific DNA binding
EXW60_RS25655	COG0346	lactoylglutathione lyase activity
EXW60_RS25680	COG2226	methyltransferase
EXW60_RS25690	COG2814	Major facilitator Superfamily
EXW60_RS25725	COG0745	RESPONSE REGULATOR receiver
EXW60_RS25730	COG5002	protein histidine kinase activity
EXW60_RS25730	COG3850	Histidine kinase
EXW60_RS25760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW60_RS25770	COG2309	aminopeptidase activity
EXW60_RS25780	COG1690	Belongs to the RtcB family
EXW60_RS25790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW60_RS25810	COG1136	(ABC) transporter
EXW60_RS25815	COG0577	efflux transmembrane transporter activity
EXW60_RS25835	COG3850	Histidine kinase
EXW60_RS25835	COG5002	protein histidine kinase activity
EXW60_RS25850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW60_RS25865	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW60_RS25885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW60_RS25915	COG5444	nuclease activity
EXW60_RS25960	COG2814	Major facilitator Superfamily
EXW60_RS26000	COG0477	Major facilitator Superfamily
EXW60_RS26015	COG1846	Transcriptional regulator
EXW60_RS26020	COG2814	Major facilitator Superfamily
EXW60_RS26065	COG0789	Transcriptional regulator
EXW60_RS26100	COG1476	TRANSCRIPTIONal
EXW60_RS26115	COG1288	antiporter activity
EXW60_RS26120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW60_RS26165	COG3718	enzyme involved in inositol metabolism
EXW60_RS26170	COG0191	fructose-bisphosphate aldolase activity
EXW60_RS26195	COG0673	inositol 2-dehydrogenase activity
EXW60_RS26200	COG2814	Major facilitator Superfamily
EXW60_RS26205	COG1609	Transcriptional regulator
EXW60_RS26245	COG2002	toxin-antitoxin pair type II binding
EXW60_RS26270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS26280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS26330	COG4187	Peptidase family M20/M25/M40
EXW60_RS26340	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW60_RS26355	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW60_RS26420	COG1288	antiporter activity
EXW60_RS26425	COG2356	endonuclease I
EXW60_RS26430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW60_RS26445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW60_RS26465	COG1785	Belongs to the alkaline phosphatase family
EXW60_RS26470	COG0778	Nitroreductase
EXW60_RS26475	COG1733	regulation of RNA biosynthetic process
EXW60_RS26495	COG1028	Short-chain dehydrogenase reductase Sdr
EXW60_RS26505	COG1131	(ABC) transporter
EXW60_RS26535	COG1595	DNA-templated transcription, initiation
EXW60_RS26550	COG1011	Hydrolase
EXW60_RS26555	COG2365	Tyrosine phosphatase family
EXW60_RS26580	COG0577	efflux transmembrane transporter activity
EXW60_RS26580	COG1136	(ABC) transporter
EXW60_RS26600	COG0628	permease
EXW60_RS26605	COG2261	transglycosylase associated protein
EXW60_RS26645	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW60_RS26655	COG1253	flavin adenine dinucleotide binding
EXW60_RS26660	COG0789	Transcriptional regulator
EXW60_RS26665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW60_RS26690	COG0697	spore germination
EXW60_RS26700	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW60_RS26705	COG3813	Protein conserved in bacteria
EXW60_RS26710	COG2706	6-phosphogluconolactonase activity
EXW60_RS26715	COG1070	Carbohydrate kinase
EXW60_RS26725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW60_RS26730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW60_RS26735	COG4702	Belongs to the UPF0303 family
EXW60_RS26745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS26765	COG0384	phenazine biosynthesis protein PhzF
EXW60_RS26785	COG0318	PFAM AMP-dependent synthetase and ligase
EXW60_RS26790	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW60_RS26795	COG1733	regulation of RNA biosynthetic process
EXW60_RS26810	COG1191	sigma factor activity
EXW60_RS26860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW60_RS26945	COG2140	Oxalate decarboxylase
EXW60_RS26960	COG0024	Methionine aminopeptidase
EXW60_RS26965	COG1923	regulation of RNA biosynthetic process
EXW60_RS26975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW60_RS26985	COG0776	regulation of translation
EXW60_RS26990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW60_RS26995	COG0367	asparagine synthase
EXW60_RS27015	COG0542	response to heat
EXW60_RS27025	COG3397	chitin binding
EXW60_RS27115	COG1404	Belongs to the peptidase S8 family
EXW60_RS27135	COG2814	Major facilitator Superfamily
EXW60_RS27140	COG2234	aminopeptidase activity
EXW60_RS27150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW60_RS27165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW60_RS27170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW60_RS27175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW60_RS27185	COG0456	acetyltransferase
EXW60_RS27210	COG0741	lytic transglycosylase activity
EXW60_RS27225	COG1674	ftsk spoiiie
EXW60_RS27240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW60_RS27265	COG5002	protein histidine kinase activity
EXW60_RS27285	COG0024	Methionine aminopeptidase
EXW60_RS27310	COG1396	sequence-specific DNA binding
EXW60_RS27485	COG2002	toxin-antitoxin pair type II binding
EXW60_RS27495	COG1923	regulation of RNA biosynthetic process
EXW60_RS27510	COG0582	viral genome integration into host DNA
EXW60_RS27525	COG2732	(Barnase) inhibitor
EXW60_RS27590	COG0662	Cupin 2, conserved barrel domain protein
EXW60_RS27600	COG1923	regulation of RNA biosynthetic process
EXW60_RS27625	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW60_RS27655	COG4974	Belongs to the 'phage' integrase family
EXW60_RS27670	COG1136	(ABC) transporter
EXW60_RS27705	COG0450	alkyl hydroperoxide reductase
EXW60_RS27710	COG0833	amino acid
EXW60_RS27720	COG1982	Orn Lys Arg decarboxylase major
EXW60_RS27740	COG0517	IMP dehydrogenase activity
EXW60_RS27740	COG4175	Glycine betaine
EXW60_RS27745	COG4176	ABC-type proline glycine betaine transport system permease component
EXW60_RS27780	COG3344	reverse transcriptase
EXW60_RS27800	COG1329	Transcriptional regulator
EXW60_RS27835	COG1131	(ABC) transporter
EXW60_RS27840	COG1725	Transcriptional regulator
EXW60_RS27855	COG0745	RESPONSE REGULATOR receiver
EXW60_RS27860	COG2205	protein histidine kinase activity
EXW60_RS27870	COG1136	(ABC) transporter
EXW60_RS27875	COG0577	efflux transmembrane transporter activity
EXW60_RS27890	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW60_RS27890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW60_RS27905	COG1136	(ABC) transporter
EXW60_RS27920	COG1309	transcriptional regulator
EXW60_RS27930	COG3858	chitin binding
EXW60_RS27935	COG0697	spore germination
EXW60_RS27955	COG0697	spore germination
EXW60_RS27965	COG0697	spore germination
EXW60_RS27970	COG2508	Transcriptional regulator
EXW60_RS27970	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW60_RS27995	COG4974	Belongs to the 'phage' integrase family
EXW60_RS28005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW60_RS28015	COG2239	Acts as a magnesium transporter
EXW60_RS28020	COG0772	Belongs to the SEDS family
EXW60_RS28025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS28030	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW60_RS28035	COG1073	alpha beta
EXW60_RS28040	COG2267	carboxylic ester hydrolase activity
EXW60_RS28045	COG1285	pathogenesis
EXW60_RS28050	COG0833	amino acid
EXW60_RS28080	COG0745	RESPONSE REGULATOR receiver
EXW60_RS28100	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW60_RS28125	COG1396	sequence-specific DNA binding
EXW60_RS28170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW60_RS28185	COG2002	toxin-antitoxin pair type II binding
EXW60_RS28265	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW60_RS28290	COG2814	Major facilitator Superfamily
EXW60_RS28340	COG1923	regulation of RNA biosynthetic process
EXW60_RS28350	COG2002	toxin-antitoxin pair type II binding
EXW60_RS28355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW60_RS28355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW60_RS28360	COG1252	NADH dehydrogenase
EXW60_RS28370	COG0697	spore germination
EXW60_RS28400	COG2239	Acts as a magnesium transporter
EXW60_RS28430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW60_RS28440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW60_RS28495	COG1846	Transcriptional regulator
EXW60_RS28530	COG4641	Protein conserved in bacteria
EXW60_RS28535	COG2089	acid synthase
EXW60_RS28550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW60_RS28555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW60_RS28560	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW60_RS28565	COG1086	Polysaccharide biosynthesis protein
EXW60_RS28625	COG0457	Tetratricopeptide repeat
EXW60_RS28660	COG1396	sequence-specific DNA binding
EXW60_RS28760	COG3883	PFAM NLP P60 protein
EXW60_RS28760	COG0791	NLP P60 protein
EXW60_RS28885	COG0582	viral genome integration into host DNA
EXW60_RS28935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW60_RS28985	COG3409	Peptidoglycan-binding domain 1 protein
EXW60_RS28995	COG0582	viral genome integration into host DNA
EXW60_RS29025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW60_RS29050	COG1247	-acetyltransferase
EXW60_RS29055	COG1285	pathogenesis
EXW60_RS29095	COG2076	Multidrug Resistance protein
EXW60_RS29540	COG0657	acetylesterase activity
EXW60_RS29540	COG2755	lipolytic protein G-D-S-L family