locus-tag	class	description
EXW27_RS00005	COG1802	Transcriptional regulator
EXW27_RS00005	COG4626	Terminase
EXW27_RS00015	COG0740	serine-type endopeptidase activity
EXW27_RS00140	COG1846	Transcriptional regulator
EXW27_RS00145	COG0778	Nitroreductase
EXW27_RS00165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW27_RS00175	COG0753	catalase activity
EXW27_RS00180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW27_RS00200	COG0714	Associated with various cellular activities
EXW27_RS00230	COG0346	lactoylglutathione lyase activity
EXW27_RS00235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS00250	COG3279	Response regulator of the LytR AlgR family
EXW27_RS00260	COG4377	Putative membrane peptidase family (DUF2324)
EXW27_RS00275	COG3655	Transcriptional regulator
EXW27_RS00285	COG1349	DNA-binding transcription factor activity
EXW27_RS00290	COG1175	transmembrane transport
EXW27_RS00315	COG3842	ATPase activity
EXW27_RS00325	COG3239	Fatty acid desaturase
EXW27_RS00330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW27_RS00335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW27_RS00340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW27_RS00345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS00365	COG2329	Antibiotic biosynthesis monooxygenase
EXW27_RS00385	COG2226	methyltransferase
EXW27_RS00405	COG2390	Transcriptional regulator
EXW27_RS00410	COG1129	ABC transporter
EXW27_RS00425	COG1879	ABC-type sugar transport system periplasmic component
EXW27_RS00430	COG0579	oxidoreductase
EXW27_RS00455	COG0431	NADPH-dependent FMN reductase
EXW27_RS00465	COG0346	lactoylglutathione lyase activity
EXW27_RS00510	COG1605	Chorismate mutase
EXW27_RS00510	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW27_RS00525	COG0287	Prephenate dehydrogenase
EXW27_RS00550	COG1309	transcriptional regulator
EXW27_RS00555	COG1033	growth of symbiont in host cell
EXW27_RS00555	COG2409	Drug exporters of the RND superfamily
EXW27_RS00560	COG0488	(ABC) transporter
EXW27_RS00575	COG1368	sulfuric ester hydrolase activity
EXW27_RS00580	COG2814	Major facilitator Superfamily
EXW27_RS00630	COG0697	spore germination
EXW27_RS00640	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW27_RS00685	COG0628	permease
EXW27_RS00730	COG2188	Transcriptional regulator
EXW27_RS00735	COG1131	(ABC) transporter
EXW27_RS00765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW27_RS00770	COG0436	Aminotransferase
EXW27_RS00805	COG2226	methyltransferase
EXW27_RS00820	COG2261	transglycosylase associated protein
EXW27_RS00840	COG0477	Major facilitator Superfamily
EXW27_RS00840	COG2814	Major facilitator Superfamily
EXW27_RS00845	COG4533	DNA binding
EXW27_RS00850	COG0789	Transcriptional regulator
EXW27_RS00855	COG1664	Polymer-forming cytoskeletal
EXW27_RS00865	COG2814	Major facilitator Superfamily
EXW27_RS00880	COG1335	isochorismatase
EXW27_RS00905	COG1307	EDD domain protein, DegV family
EXW27_RS00920	COG1522	sequence-specific DNA binding
EXW27_RS00925	COG0531	amino acid
EXW27_RS00930	COG1164	Oligoendopeptidase f
EXW27_RS00960	COG0745	RESPONSE REGULATOR receiver
EXW27_RS00970	COG2936	dipeptidyl-peptidase activity
EXW27_RS01010	COG0667	Aldo Keto reductase
EXW27_RS01030	COG4948	Mandelate Racemase Muconate Lactonizing
EXW27_RS01040	COG4166	transmembrane transport
EXW27_RS01045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW27_RS01060	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS01100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW27_RS01105	COG3938	Belongs to the proline racemase family
EXW27_RS01115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW27_RS01120	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS01125	COG1115	amino acid carrier protein
EXW27_RS01130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW27_RS01150	COG2318	DinB family
EXW27_RS01155	COG3397	chitin binding
EXW27_RS01160	COG1227	inorganic diphosphatase activity
EXW27_RS01170	COG4637	Psort location Cytoplasmic, score
EXW27_RS01195	COG0514	ATP-dependent DNA helicase (RecQ)
EXW27_RS01210	COG3973	AAA domain
EXW27_RS01270	COG2315	Protein conserved in bacteria
EXW27_RS01275	COG2226	methyltransferase
EXW27_RS01280	COG2205	protein histidine kinase activity
EXW27_RS01300	COG1819	glycosyl
EXW27_RS01310	COG3397	chitin binding
EXW27_RS01315	COG2153	protein acetylation
EXW27_RS01320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW27_RS01345	COG0517	IMP dehydrogenase activity
EXW27_RS01345	COG4175	Glycine betaine
EXW27_RS01350	COG4176	ABC-type proline glycine betaine transport system permease component
EXW27_RS01380	COG0456	acetyltransferase
EXW27_RS01380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW27_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS01405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW27_RS01410	COG0022	dehydrogenase e1 component
EXW27_RS01415	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW27_RS01420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW27_RS01435	COG1959	2 iron, 2 sulfur cluster binding
EXW27_RS01455	COG1349	DNA-binding transcription factor activity
EXW27_RS01470	COG3284	Transcriptional regulator
EXW27_RS01485	COG1309	transcriptional regulator
EXW27_RS01490	COG3844	kynureninase activity
EXW27_RS01495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW27_RS01500	COG3483	tryptophan 2,3-dioxygenase activity
EXW27_RS01525	COG2959	enzyme of heme biosynthesis
EXW27_RS01540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS01580	COG3386	PFAM SMP-30 Gluconolaconase
EXW27_RS01590	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW27_RS01595	COG3773	Cell wall hydrolase
EXW27_RS01605	COG0745	RESPONSE REGULATOR receiver
EXW27_RS01610	COG2205	protein histidine kinase activity
EXW27_RS01615	COG0583	DNA-binding transcription factor activity
EXW27_RS01620	COG0667	Aldo Keto reductase
EXW27_RS01625	COG0488	(ABC) transporter
EXW27_RS01635	COG1136	(ABC) transporter
EXW27_RS01640	COG0577	efflux transmembrane transporter activity
EXW27_RS01660	COG0460	homoserine dehydrogenase
EXW27_RS01665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS01675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW27_RS01720	COG2124	cytochrome p450
EXW27_RS01765	COG0561	phosphatase activity
EXW27_RS01770	COG5002	protein histidine kinase activity
EXW27_RS01775	COG0768	penicillin binding
EXW27_RS01785	COG1819	glycosyl
EXW27_RS01790	COG1794	racemase activity, acting on amino acids and derivatives
EXW27_RS01795	COG4720	Psort location CytoplasmicMembrane, score
EXW27_RS01800	COG1122	ATPase activity
EXW27_RS01815	COG2205	protein histidine kinase activity
EXW27_RS01825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW27_RS01835	COG0745	RESPONSE REGULATOR receiver
EXW27_RS01840	COG5002	protein histidine kinase activity
EXW27_RS01845	COG0604	alcohol dehydrogenase
EXW27_RS01850	COG0671	phosphoesterase, PA-phosphatase related
EXW27_RS01855	COG0768	penicillin binding
EXW27_RS01895	COG2814	Major facilitator Superfamily
EXW27_RS01910	COG0584	glycerophosphoryl diester phosphodiesterase
EXW27_RS01925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS01930	COG0697	spore germination
EXW27_RS01960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW27_RS01970	COG2223	nitrite transmembrane transporter activity
EXW27_RS01980	COG2816	NAD+ diphosphatase activity
EXW27_RS01985	COG0592	DNA-directed DNA polymerase activity
EXW27_RS01990	COG1051	belongs to the nudix hydrolase family
EXW27_RS02015	COG3878	Protein conserved in bacteria
EXW27_RS02040	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW27_RS02055	COG2318	DinB family
EXW27_RS02080	COG0322	excinuclease ABC activity
EXW27_RS02100	COG3961	Belongs to the TPP enzyme family
EXW27_RS02110	COG1132	(ABC) transporter
EXW27_RS02120	COG1183	phosphatidylcholine synthase activity
EXW27_RS02125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW27_RS02145	COG1011	Hydrolase
EXW27_RS02150	COG0745	RESPONSE REGULATOR receiver
EXW27_RS02155	COG5002	protein histidine kinase activity
EXW27_RS02185	COG1136	(ABC) transporter
EXW27_RS02190	COG0577	efflux transmembrane transporter activity
EXW27_RS02200	COG1073	alpha beta
EXW27_RS02205	COG0657	acetylesterase activity
EXW27_RS02210	COG0076	glutamate decarboxylase activity
EXW27_RS02225	COG1523	belongs to the glycosyl hydrolase 13 family
EXW27_RS02230	COG3227	Zinc metalloprotease (Elastase)
EXW27_RS02235	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS02245	COG0201	protein transport
EXW27_RS02265	COG0697	spore germination
EXW27_RS02270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS02285	COG2323	membrane
EXW27_RS02320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS02325	COG0697	spore germination
EXW27_RS02355	COG1309	transcriptional regulator
EXW27_RS02380	COG1733	regulation of RNA biosynthetic process
EXW27_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS02410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW27_RS02435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW27_RS02460	COG1686	Belongs to the peptidase S11 family
EXW27_RS02515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW27_RS02520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW27_RS02525	COG1024	Enoyl-CoA hydratase
EXW27_RS02530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW27_RS02535	COG0511	ligase activity, forming carbon-carbon bonds
EXW27_RS02540	COG0439	Biotin carboxylase
EXW27_RS02545	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS02555	COG1309	transcriptional regulator
EXW27_RS02565	COG1131	(ABC) transporter
EXW27_RS02575	COG1408	metallophosphoesterase
EXW27_RS02585	COG0823	Involved in the tonB-independent uptake of proteins
EXW27_RS02590	COG3397	chitin binding
EXW27_RS02620	COG0697	spore germination
EXW27_RS02635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW27_RS02650	COG2239	Acts as a magnesium transporter
EXW27_RS02660	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS02735	COG2723	6-phospho-beta-galactosidase activity
EXW27_RS02750	COG1136	(ABC) transporter
EXW27_RS02770	COG0577	efflux transmembrane transporter activity
EXW27_RS02775	COG1136	(ABC) transporter
EXW27_RS02800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS02800	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW27_RS02815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS02815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS02820	COG1252	NADH dehydrogenase
EXW27_RS02855	COG0768	penicillin binding
EXW27_RS02860	COG0768	penicillin binding
EXW27_RS02870	COG1595	DNA-templated transcription, initiation
EXW27_RS02880	COG0577	efflux transmembrane transporter activity
EXW27_RS02885	COG1136	(ABC) transporter
EXW27_RS02890	COG2205	protein histidine kinase activity
EXW27_RS02895	COG0745	RESPONSE REGULATOR receiver
EXW27_RS02900	COG0768	penicillin binding
EXW27_RS02925	COG1686	Belongs to the peptidase S11 family
EXW27_RS02950	COG1136	(ABC) transporter
EXW27_RS02955	COG0110	maltose O-acetyltransferase activity
EXW27_RS02965	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW27_RS02990	COG0588	phosphoglycerate mutase activity
EXW27_RS03000	COG0693	protein deglycase activity
EXW27_RS03010	COG0500	methyltransferase
EXW27_RS03010	COG3615	Tellurite resistance protein tehB
EXW27_RS03015	COG1136	(ABC) transporter
EXW27_RS03030	COG1309	transcriptional regulator
EXW27_RS03070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW27_RS03080	COG2971	BadF BadG BcrA BcrD
EXW27_RS03085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW27_RS03105	COG1649	PFAM Uncharacterised BCR, COG1649
EXW27_RS03130	COG1595	DNA-templated transcription, initiation
EXW27_RS03135	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW27_RS03170	COG1396	sequence-specific DNA binding
EXW27_RS03195	COG0189	ligase activity
EXW27_RS03210	COG1132	(ABC) transporter
EXW27_RS03215	COG1132	(ABC) transporter
EXW27_RS03230	COG2258	MOSC domain
EXW27_RS03235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS03240	COG0583	DNA-binding transcription factor activity
EXW27_RS03255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW27_RS03260	COG0583	DNA-binding transcription factor activity
EXW27_RS03270	COG0561	phosphatase activity
EXW27_RS03295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS03305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW27_RS03335	COG1247	-acetyltransferase
EXW27_RS03365	COG1309	transcriptional regulator
EXW27_RS03370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS03380	COG1846	Transcriptional regulator
EXW27_RS03400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW27_RS03440	COG1253	flavin adenine dinucleotide binding
EXW27_RS03460	COG0028	Belongs to the TPP enzyme family
EXW27_RS03475	COG0596	Alpha beta hydrolase
EXW27_RS03485	COG1136	(ABC) transporter
EXW27_RS03495	COG3655	Transcriptional regulator
EXW27_RS03500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW27_RS03505	COG1187	pseudouridine synthase activity
EXW27_RS03515	COG2329	Antibiotic biosynthesis monooxygenase
EXW27_RS03530	COG1115	amino acid carrier protein
EXW27_RS03535	COG2318	DinB family
EXW27_RS03545	COG0776	regulation of translation
EXW27_RS03560	COG2814	Major facilitator Superfamily
EXW27_RS03565	COG3251	PFAM MbtH domain protein
EXW27_RS03570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW27_RS03575	COG3433	isochorismatase activity
EXW27_RS03575	COG1535	isochorismatase
EXW27_RS03580	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW27_RS03585	COG1169	isochorismate synthase
EXW27_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS03595	COG2223	nitrite transmembrane transporter activity
EXW27_RS03620	COG0420	3'-5' exonuclease activity
EXW27_RS03635	COG1024	Enoyl-CoA hydratase
EXW27_RS03640	COG1280	lysine exporter protein (LysE YggA)
EXW27_RS03645	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS03650	COG2084	Dehydrogenase
EXW27_RS03655	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS03660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW27_RS03665	COG2079	MmgE PrpD family protein
EXW27_RS03670	COG0372	Belongs to the citrate synthase family
EXW27_RS03690	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW27_RS03690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS03740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW27_RS03795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS03800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW27_RS03805	COG0671	phosphoesterase, PA-phosphatase related
EXW27_RS03815	COG4991	sh3 domain protein
EXW27_RS03815	COG0515	serine threonine protein kinase
EXW27_RS03815	COG3064	Membrane
EXW27_RS03840	COG4479	Belongs to the UPF0346 family
EXW27_RS03850	COG1509	lysine 2,3-aminomutase activity
EXW27_RS03855	COG3829	transcription factor binding
EXW27_RS03860	COG0456	acetyltransferase
EXW27_RS03865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW27_RS03870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW27_RS03875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW27_RS03880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW27_RS03895	COG5506	Protein of unknown function (DUF1694)
EXW27_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS03905	COG1253	flavin adenine dinucleotide binding
EXW27_RS03940	COG1174	glycine betaine transport
EXW27_RS03945	COG0517	IMP dehydrogenase activity
EXW27_RS03945	COG1125	glycine betaine transport
EXW27_RS03965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW27_RS03975	COG1070	Carbohydrate kinase
EXW27_RS03990	COG1064	alcohol dehydrogenase
EXW27_RS04010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXW27_RS04015	COG1737	Transcriptional regulator
EXW27_RS04020	COG2197	response regulator
EXW27_RS04025	COG2203	Gaf domain
EXW27_RS04025	COG4585	Histidine kinase
EXW27_RS04030	COG0668	transmembrane transport
EXW27_RS04040	COG1335	isochorismatase
EXW27_RS04060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS04065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS04070	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS04085	COG0367	asparagine synthase
EXW27_RS04090	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW27_RS04095	COG1999	signal sequence binding
EXW27_RS04100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW27_RS04115	COG0805	protein transport
EXW27_RS04120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW27_RS04125	COG1272	protein, Hemolysin III
EXW27_RS04130	COG0204	Acyl-transferase
EXW27_RS04140	COG0768	penicillin binding
EXW27_RS04155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW27_RS04170	COG0546	phosphoglycolate phosphatase activity
EXW27_RS04180	COG4473	ABC transporter
EXW27_RS04185	COG1131	(ABC) transporter
EXW27_RS04195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW27_RS04200	COG0456	acetyltransferase
EXW27_RS04210	COG1794	racemase activity, acting on amino acids and derivatives
EXW27_RS04220	COG2610	gluconate transmembrane transporter activity
EXW27_RS04245	COG0733	neurotransmitter:sodium symporter activity
EXW27_RS04250	COG0017	Asparaginyl-tRNA synthetase
EXW27_RS04300	COG0018	arginyl-trna synthetase
EXW27_RS04305	COG2521	methyltransferase
EXW27_RS04305	COG2136	Putative SAM-dependent methyltransferase
EXW27_RS04320	COG1413	lyase activity
EXW27_RS04380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW27_RS04410	COG0488	(ABC) transporter
EXW27_RS04415	COG1418	mRNA catabolic process
EXW27_RS04435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS04440	COG0582	viral genome integration into host DNA
EXW27_RS04485	COG2359	stage V sporulation protein S
EXW27_RS04520	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW27_RS04525	COG0714	Associated with various cellular activities
EXW27_RS04530	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW27_RS04535	COG1305	Transglutaminase-like
EXW27_RS04540	COG0386	Belongs to the glutathione peroxidase family
EXW27_RS04550	COG0426	domain, Protein
EXW27_RS04550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW27_RS04575	COG1595	DNA-templated transcription, initiation
EXW27_RS04580	COG0604	alcohol dehydrogenase
EXW27_RS04610	COG2226	methyltransferase
EXW27_RS04635	COG3874	Sporulation protein YtfJ
EXW27_RS04695	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW27_RS04730	COG0456	acetyltransferase
EXW27_RS04755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS04760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS04765	COG1819	glycosyl
EXW27_RS04780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW27_RS04790	COG0561	phosphatase activity
EXW27_RS04800	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS04815	COG2211	Major facilitator Superfamily
EXW27_RS04830	COG1876	peptidase activity
EXW27_RS04840	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS04855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW27_RS04860	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS04885	COG1253	flavin adenine dinucleotide binding
EXW27_RS04890	COG2839	Protein conserved in bacteria
EXW27_RS04895	COG0702	epimerase
EXW27_RS04910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW27_RS04920	COG1607	acyl-coa hydrolase
EXW27_RS04925	COG3689	TIGRFAM TIGR03943 family protein
EXW27_RS04930	COG0701	Predicted permease
EXW27_RS04940	COG2244	polysaccharide biosynthetic process
EXW27_RS04945	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS04950	COG1051	belongs to the nudix hydrolase family
EXW27_RS04955	COG5337	Spore coat protein CotH
EXW27_RS04965	COG0406	alpha-ribazole phosphatase activity
EXW27_RS04975	COG0346	lactoylglutathione lyase activity
EXW27_RS04980	COG4166	transmembrane transport
EXW27_RS04990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW27_RS04995	COG1902	pentaerythritol trinitrate reductase activity
EXW27_RS05000	COG2205	protein histidine kinase activity
EXW27_RS05005	COG0745	RESPONSE REGULATOR receiver
EXW27_RS05010	COG0577	efflux transmembrane transporter activity
EXW27_RS05015	COG1136	(ABC) transporter
EXW27_RS05020	COG2814	Major facilitator Superfamily
EXW27_RS05040	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW27_RS05045	COG0456	acetyltransferase
EXW27_RS05050	COG0523	cobalamin synthesis protein
EXW27_RS05055	COG4989	oxidoreductase activity
EXW27_RS05060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS05065	COG1231	oxidoreductase activity
EXW27_RS05075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW27_RS05090	COG0783	Belongs to the Dps family
EXW27_RS05095	COG3949	Membrane
EXW27_RS05140	COG0667	Aldo Keto reductase
EXW27_RS05145	COG0640	Transcriptional regulator
EXW27_RS05150	COG1404	Belongs to the peptidase S8 family
EXW27_RS05155	COG2002	toxin-antitoxin pair type II binding
EXW27_RS05160	COG0577	efflux transmembrane transporter activity
EXW27_RS05165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW27_RS05195	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW27_RS05205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS05210	COG1279	arginine transmembrane transporter activity
EXW27_RS05215	COG2814	Major facilitator Superfamily
EXW27_RS05225	COG1082	Xylose isomerase domain protein TIM barrel
EXW27_RS05235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW27_RS05255	COG1247	-acetyltransferase
EXW27_RS05260	COG1285	pathogenesis
EXW27_RS05280	COG1316	TRANSCRIPTIONal
EXW27_RS05295	COG0083	homoserine kinase activity
EXW27_RS05305	COG0460	homoserine dehydrogenase
EXW27_RS05335	COG4122	O-methyltransferase activity
EXW27_RS05340	COG0300	oxidoreductase activity
EXW27_RS05345	COG5002	protein histidine kinase activity
EXW27_RS05350	COG0745	RESPONSE REGULATOR receiver
EXW27_RS05355	COG1132	(ABC) transporter
EXW27_RS05365	COG0791	NLP P60 protein
EXW27_RS05365	COG1388	LysM domain
EXW27_RS05380	COG1686	Belongs to the peptidase S11 family
EXW27_RS05410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW27_RS05415	COG4988	ABC transporter
EXW27_RS05420	COG1294	oxidase, subunit
EXW27_RS05425	COG1271	oxidase subunit
EXW27_RS05435	COG0346	lactoylglutathione lyase activity
EXW27_RS05460	COG0583	DNA-binding transcription factor activity
EXW27_RS05480	COG0411	ABC transporter
EXW27_RS05495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW27_RS05500	COG2030	dehydratase
EXW27_RS05505	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS05515	COG0523	cobalamin synthesis protein
EXW27_RS05520	COG1231	oxidoreductase activity
EXW27_RS05535	COG0628	permease
EXW27_RS05550	COG0778	Nitroreductase
EXW27_RS05555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW27_RS05560	COG1959	2 iron, 2 sulfur cluster binding
EXW27_RS05565	COG0583	DNA-binding transcription factor activity
EXW27_RS05570	COG0697	spore germination
EXW27_RS05580	COG4549	nuclear export factor GLE1
EXW27_RS05585	COG2372	response to copper ion
EXW27_RS05585	COG1276	copper resistance
EXW27_RS05595	COG4641	Protein conserved in bacteria
EXW27_RS05605	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS05625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW27_RS05635	COG2132	Multicopper oxidase
EXW27_RS05640	COG0006	proline dipeptidase activity
EXW27_RS05660	COG0583	DNA-binding transcription factor activity
EXW27_RS05675	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW27_RS05690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW27_RS05695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS05700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW27_RS05710	COG2390	Transcriptional regulator
EXW27_RS05715	COG4257	antibiotic catabolic process
EXW27_RS05730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW27_RS05765	COG0531	amino acid
EXW27_RS05770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW27_RS05780	COG1054	Belongs to the UPF0176 family
EXW27_RS05785	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW27_RS05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS05800	COG4166	transmembrane transport
EXW27_RS05845	COG3384	dioxygenase
EXW27_RS05850	COG2814	Major facilitator Superfamily
EXW27_RS05875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW27_RS05880	COG0129	dihydroxy-acid dehydratase activity
EXW27_RS05895	COG0028	Belongs to the TPP enzyme family
EXW27_RS05900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS05910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW27_RS05925	COG2323	membrane
EXW27_RS05930	COG5566	PFAM Mor transcription activator
EXW27_RS05940	COG0733	neurotransmitter:sodium symporter activity
EXW27_RS05945	COG2244	polysaccharide biosynthetic process
EXW27_RS05960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW27_RS05965	COG2223	nitrite transmembrane transporter activity
EXW27_RS05970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW27_RS05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW27_RS05985	COG0477	Major facilitator Superfamily
EXW27_RS05990	COG0640	Transcriptional regulator
EXW27_RS05995	COG2814	Major facilitator Superfamily
EXW27_RS06005	COG1695	Transcriptional regulator
EXW27_RS06030	COG2814	Major facilitator Superfamily
EXW27_RS06040	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS06045	COG1051	belongs to the nudix hydrolase family
EXW27_RS06085	COG2502	aspartate--ammonia ligase
EXW27_RS06095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW27_RS06105	COG1846	Transcriptional regulator
EXW27_RS06110	COG0784	Response regulator, receiver
EXW27_RS06115	COG4191	Histidine kinase
EXW27_RS06120	COG0281	malic enzyme
EXW27_RS06125	COG1027	Aspartate ammonia-lyase
EXW27_RS06135	COG0528	UMP kinase activity
EXW27_RS06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW27_RS06155	COG1131	(ABC) transporter
EXW27_RS06190	COG2733	membrane
EXW27_RS06195	COG3048	D-serine ammonia-lyase activity
EXW27_RS06210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS06215	COG0785	Cytochrome C biogenesis protein
EXW27_RS06235	COG3340	Belongs to the peptidase S51 family
EXW27_RS06240	COG0534	Mate efflux family protein
EXW27_RS06260	COG0277	FAD linked oxidase domain protein
EXW27_RS06270	COG1757	Na H antiporter
EXW27_RS06275	COG1216	Glycosyl transferase, family 2
EXW27_RS06275	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS06285	COG0697	spore germination
EXW27_RS06290	COG1802	Transcriptional regulator
EXW27_RS06320	COG0367	asparagine synthase
EXW27_RS06350	COG0406	alpha-ribazole phosphatase activity
EXW27_RS06400	COG3842	ATPase activity
EXW27_RS06405	COG0583	DNA-binding transcription factor activity
EXW27_RS06415	COG2814	Major facilitator Superfamily
EXW27_RS06430	COG2329	Antibiotic biosynthesis monooxygenase
EXW27_RS06435	COG0412	Dienelactone hydrolase
EXW27_RS06465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW27_RS06470	COG4786	Flagellar basal body rod
EXW27_RS06475	COG1419	protein localization to endoplasmic reticulum
EXW27_RS06480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW27_RS06485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW27_RS06495	COG1987	bacterial-type flagellum assembly
EXW27_RS06500	COG1338	Plays a role in the flagellum-specific transport system
EXW27_RS06510	COG1776	CheC inhibitor of MCP methylation
EXW27_RS06510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW27_RS06515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW27_RS06525	COG0741	lytic transglycosylase activity
EXW27_RS06530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW27_RS06535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW27_RS06540	COG0489	protein tyrosine kinase activity
EXW27_RS06550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW27_RS06555	COG0314	molybdopterin synthase activity
EXW27_RS06560	COG0303	'Molybdopterin
EXW27_RS06565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW27_RS06570	COG2116	formate transmembrane transporter activity
EXW27_RS06580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW27_RS06585	COG5609	conserved protein (DUF2294)
EXW27_RS06590	COG2427	Protein of unknown function (DUF1641)
EXW27_RS06595	COG3383	formate dehydrogenase (NAD+) activity
EXW27_RS06605	COG0861	Integral membrane protein TerC family
EXW27_RS06625	COG0784	Response regulator, receiver
EXW27_RS06625	COG0835	chemotaxis
EXW27_RS06640	COG1749	Flagellar hook protein flgE
EXW27_RS06660	COG1157	protein secretion by the type III secretion system
EXW27_RS06670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW27_RS06675	COG1766	The M ring may be actively involved in energy transduction
EXW27_RS06685	COG1558	bacterial-type flagellum-dependent cell motility
EXW27_RS06690	COG1815	bacterial-type flagellum-dependent cell motility
EXW27_RS06710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW27_RS06715	COG1256	bacterial-type flagellum assembly
EXW27_RS06735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW27_RS06750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW27_RS06750	COG1776	CheC inhibitor of MCP methylation
EXW27_RS06755	COG2198	Histidine kinase
EXW27_RS06755	COG0643	Histidine kinase
EXW27_RS06760	COG2201	protein-glutamate methylesterase activity
EXW27_RS06765	COG1360	Flagellar Motor Protein
EXW27_RS06770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW27_RS06780	COG1923	regulation of RNA biosynthetic process
EXW27_RS06835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW27_RS06840	COG2323	membrane
EXW27_RS06850	COG4978	Transcriptional regulator
EXW27_RS06850	COG0789	Transcriptional regulator
EXW27_RS06855	COG0475	glutathione-regulated potassium exporter activity
EXW27_RS06865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW27_RS06870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW27_RS06875	COG3162	membrane
EXW27_RS06890	COG1280	lysine exporter protein (LysE YggA)
EXW27_RS06895	COG3403	YqcI/YcgG family
EXW27_RS06930	COG0328	RNA-DNA hybrid ribonuclease activity
EXW27_RS06950	COG0454	-acetyltransferase
EXW27_RS06965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW27_RS07005	COG2897	thiosulfate sulfurtransferase activity
EXW27_RS07015	COG0456	acetyltransferase
EXW27_RS07025	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW27_RS07035	COG2311	Membrane
EXW27_RS07040	COG2233	PERMEase
EXW27_RS07050	COG0024	Methionine aminopeptidase
EXW27_RS07060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW27_RS07065	COG1199	ATP-dependent helicase activity
EXW27_RS07075	COG0116	Belongs to the methyltransferase superfamily
EXW27_RS07085	COG3599	regulation of cell shape
EXW27_RS07090	COG4474	Belongs to the UPF0398 family
EXW27_RS07125	COG3331	DNA recombination
EXW27_RS07130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS07130	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW27_RS07140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW27_RS07145	COG3935	DnaD domain protein
EXW27_RS07165	COG1199	ATP-dependent helicase activity
EXW27_RS07165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW27_RS07175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW27_RS07180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW27_RS07190	COG0617	tRNA 3'-terminal CCA addition
EXW27_RS07195	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS07200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW27_RS07205	COG1803	Methylglyoxal synthase
EXW27_RS07210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW27_RS07215	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW27_RS07220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS07230	COG2738	Putative neutral zinc metallopeptidase
EXW27_RS07245	COG4347	Protein of unknown function (DUF1405)
EXW27_RS07260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW27_RS07275	COG5582	Belongs to the UPF0302 family
EXW27_RS07280	COG0457	Tetratricopeptide repeat
EXW27_RS07285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW27_RS07295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW27_RS07310	COG0142	geranyltranstransferase activity
EXW27_RS07315	COG2226	methyltransferase
EXW27_RS07320	COG0142	geranyltranstransferase activity
EXW27_RS07325	COG0302	gtp cyclohydrolase
EXW27_RS07335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW27_RS07355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW27_RS07360	COG1160	GTP binding
EXW27_RS07390	COG1304	FMN binding
EXW27_RS07400	COG2801	Transposase and inactivated derivatives
EXW27_RS07410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW27_RS07420	COG0252	asparaginase activity
EXW27_RS07425	COG0492	ferredoxin-NADP+ reductase activity
EXW27_RS07445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW27_RS07460	COG1408	metallophosphoesterase
EXW27_RS07470	COG1266	CAAX protease self-immunity
EXW27_RS07475	COG0514	ATP-dependent DNA helicase (RecQ)
EXW27_RS07480	COG4955	Helix-turn-helix domain
EXW27_RS07485	COG1141	Ferredoxin
EXW27_RS07490	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW27_RS07500	COG4942	peptidase
EXW27_RS07505	COG2096	Adenosyltransferase
EXW27_RS07510	COG5002	protein histidine kinase activity
EXW27_RS07515	COG0745	RESPONSE REGULATOR receiver
EXW27_RS07520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW27_RS07525	COG1333	cytochrome c biogenesis protein
EXW27_RS07535	COG1187	pseudouridine synthase activity
EXW27_RS07540	COG0700	Nucleoside recognition
EXW27_RS07545	COG2715	membrane protein required for spore maturation
EXW27_RS07550	COG1686	Belongs to the peptidase S11 family
EXW27_RS07555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW27_RS07570	COG0392	lysyltransferase activity
EXW27_RS07570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW27_RS07585	COG5002	protein histidine kinase activity
EXW27_RS07590	COG0582	viral genome integration into host DNA
EXW27_RS07605	COG1801	Protein of unknown function DUF72
EXW27_RS07610	COG3852	Histidine kinase
EXW27_RS07625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS07630	COG1392	Phosphate transport regulator
EXW27_RS07635	COG0306	phosphate transporter
EXW27_RS07640	COG0730	response to heat
EXW27_RS07680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW27_RS07690	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS07700	COG2197	response regulator
EXW27_RS07705	COG4585	Histidine kinase
EXW27_RS07710	COG4758	membrane
EXW27_RS07725	COG1757	Na H antiporter
EXW27_RS07750	COG0733	neurotransmitter:sodium symporter activity
EXW27_RS07755	COG1648	precorrin-2 dehydrogenase activity
EXW27_RS07775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW27_RS07780	COG0529	Catalyzes the synthesis of activated sulfate
EXW27_RS07785	COG2046	Belongs to the sulfate adenylyltransferase family
EXW27_RS07790	COG0175	sulfate reduction
EXW27_RS07800	COG0019	diaminopimelate decarboxylase activity
EXW27_RS07810	COG1368	sulfuric ester hydrolase activity
EXW27_RS07815	COG1183	phosphatidylcholine synthase activity
EXW27_RS07830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW27_RS07835	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW27_RS07845	COG0107	imidazoleglycerol-phosphate synthase activity
EXW27_RS07850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW27_RS07855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW27_RS07860	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW27_RS07870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW27_RS07875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW27_RS07885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW27_RS07895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW27_RS07905	COG0440	acetolactate synthase activity
EXW27_RS07910	COG0028	Belongs to the TPP enzyme family
EXW27_RS07915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS07940	COG3874	Sporulation protein YtfJ
EXW27_RS07950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW27_RS07955	COG1301	dicarboxylic acid transport
EXW27_RS07965	COG1846	Transcriptional regulator
EXW27_RS07990	COG0534	Mate efflux family protein
EXW27_RS08025	COG0716	FMN binding
EXW27_RS08050	COG1696	Membrane protein involved in D-alanine export
EXW27_RS08055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW27_RS08060	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW27_RS08065	COG2070	2-Nitropropane dioxygenase
EXW27_RS08070	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW27_RS08080	COG1335	isochorismatase
EXW27_RS08090	COG1522	sequence-specific DNA binding
EXW27_RS08100	COG1266	CAAX protease self-immunity
EXW27_RS08105	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW27_RS08110	COG1131	(ABC) transporter
EXW27_RS08120	COG1131	(ABC) transporter
EXW27_RS08125	COG1725	Transcriptional regulator
EXW27_RS08135	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS08140	COG2204	response regulator
EXW27_RS08155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW27_RS08160	COG0531	amino acid
EXW27_RS08165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW27_RS08180	COG1780	Probably involved in ribonucleotide reductase function
EXW27_RS08195	COG0456	acetyltransferase
EXW27_RS08210	COG4873	Protein conserved in bacteria
EXW27_RS08215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW27_RS08225	COG0720	synthase
EXW27_RS08230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW27_RS08235	COG5002	protein histidine kinase activity
EXW27_RS08240	COG2318	DinB family
EXW27_RS08250	COG1846	Transcriptional regulator
EXW27_RS08255	COG3852	Histidine kinase
EXW27_RS08265	COG2861	carbohydrate metabolic process
EXW27_RS08275	COG0235	Class ii aldolase
EXW27_RS08285	COG1349	DNA-binding transcription factor activity
EXW27_RS08295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW27_RS08300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW27_RS08310	COG3842	ATPase activity
EXW27_RS08315	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW27_RS08330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW27_RS08340	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW27_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS08365	COG2030	dehydratase
EXW27_RS08375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW27_RS08380	COG0861	Integral membrane protein TerC family
EXW27_RS08385	COG2116	formate transmembrane transporter activity
EXW27_RS08395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW27_RS08400	COG1556	Lactate utilization protein
EXW27_RS08405	COG1139	Iron-sulfur cluster binding protein
EXW27_RS08410	COG0247	lactate metabolic process
EXW27_RS08415	COG2186	Transcriptional regulator
EXW27_RS08420	COG5002	protein histidine kinase activity
EXW27_RS08425	COG0745	RESPONSE REGULATOR receiver
EXW27_RS08435	COG3835	regulator
EXW27_RS08440	COG0277	FAD linked oxidase domain protein
EXW27_RS08445	COG0247	lactate metabolic process
EXW27_RS08450	COG2340	Cysteine-rich secretory protein family
EXW27_RS08460	COG0564	pseudouridine synthase activity
EXW27_RS08470	COG2409	Drug exporters of the RND superfamily
EXW27_RS08480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW27_RS08485	COG1177	transmembrane transport
EXW27_RS08490	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW27_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS08535	COG0681	Belongs to the peptidase S26 family
EXW27_RS08540	COG1686	Belongs to the peptidase S11 family
EXW27_RS08560	COG1668	transmembrane transport
EXW27_RS08565	COG4152	abc transporter atp-binding protein
EXW27_RS08590	COG1476	TRANSCRIPTIONal
EXW27_RS08595	COG0567	Dehydrogenase, E1 component
EXW27_RS08600	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW27_RS08730	COG5634	Uncharacterized conserved protein (DUF2278)
EXW27_RS08735	COG1620	l-lactate permease
EXW27_RS08745	COG0159	tryptophan synthase activity
EXW27_RS08750	COG0133	tryptophan synthase activity
EXW27_RS08755	COG0135	phosphoribosylanthranilate isomerase activity
EXW27_RS08760	COG0134	indole-3-glycerol-phosphate synthase activity
EXW27_RS08765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW27_RS08770	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW27_RS08770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW27_RS08780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW27_RS08785	COG5492	domain, Protein
EXW27_RS08810	COG2382	esterase
EXW27_RS08815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW27_RS08820	COG2153	protein acetylation
EXW27_RS08865	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW27_RS08880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW27_RS08900	COG0457	Tetratricopeptide repeat
EXW27_RS08900	COG0463	Glycosyl transferase, family 2
EXW27_RS08920	COG1216	Glycosyl transferase, family 2
EXW27_RS08925	COG0772	Belongs to the SEDS family
EXW27_RS08930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW27_RS08940	COG0564	pseudouridine synthase activity
EXW27_RS08950	COG2357	RelA SpoT domain protein
EXW27_RS08960	COG4116	CYTH
EXW27_RS08965	COG2346	COG2346, Truncated hemoglobins
EXW27_RS08975	COG1164	Oligoendopeptidase f
EXW27_RS08985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW27_RS08990	COG4862	establishment of competence for transformation
EXW27_RS08995	COG0861	Integral membrane protein TerC family
EXW27_RS09010	COG4166	transmembrane transport
EXW27_RS09015	COG0534	Mate efflux family protein
EXW27_RS09020	COG4608	Belongs to the ABC transporter superfamily
EXW27_RS09025	COG0444	Belongs to the ABC transporter superfamily
EXW27_RS09030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW27_RS09035	COG0601	transmembrane transport
EXW27_RS09040	COG4166	transmembrane transport
EXW27_RS09050	COG0180	Tryptophanyl-tRNA synthetase
EXW27_RS09060	COG5504	Zn-dependent protease
EXW27_RS09065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW27_RS09070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW27_RS09090	COG2267	carboxylic ester hydrolase activity
EXW27_RS09110	COG0561	phosphatase activity
EXW27_RS09125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS09135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW27_RS09145	COG2996	Protein conserved in bacteria
EXW27_RS09150	COG1666	GTP binding
EXW27_RS09160	COG0004	ammonium transporteR
EXW27_RS09165	COG0753	catalase activity
EXW27_RS09175	COG0367	asparagine synthase
EXW27_RS09200	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW27_RS09250	COG1074	ATP-dependent DNA helicase activity
EXW27_RS09255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW27_RS09265	COG0398	Pfam SNARE associated Golgi protein
EXW27_RS09270	COG4903	ComK protein
EXW27_RS09280	COG1278	Cold shock
EXW27_RS09290	COG2224	Isocitrate lyase
EXW27_RS09295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW27_RS09320	COG0697	spore germination
EXW27_RS09325	COG0501	Belongs to the peptidase M48B family
EXW27_RS09340	COG0745	RESPONSE REGULATOR receiver
EXW27_RS09345	COG2205	protein histidine kinase activity
EXW27_RS09350	COG2207	Transcriptional regulator
EXW27_RS09350	COG3708	Transcriptional regulator
EXW27_RS09355	COG1595	DNA-templated transcription, initiation
EXW27_RS09365	COG1078	dGTPase activity
EXW27_RS09370	COG1408	metallophosphoesterase
EXW27_RS09385	COG4208	sulfate ABC transporter
EXW27_RS09390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW27_RS09395	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW27_RS09410	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS09420	COG0095	Lipoate-protein ligase
EXW27_RS09425	COG1234	tRNA 3'-trailer cleavage
EXW27_RS09435	COG1609	Transcriptional regulator
EXW27_RS09475	COG1511	domain protein
EXW27_RS09480	COG1309	transcriptional regulator
EXW27_RS09500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW27_RS09505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW27_RS09510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW27_RS09515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS09520	COG2329	Antibiotic biosynthesis monooxygenase
EXW27_RS09525	COG3428	Bacterial PH domain
EXW27_RS09530	COG3402	PFAM membrane-flanked domain
EXW27_RS09545	COG3428	Bacterial PH domain
EXW27_RS09550	COG3402	PFAM membrane-flanked domain
EXW27_RS09570	COG1556	Lactate utilization protein
EXW27_RS09575	COG1139	Iron-sulfur cluster binding protein
EXW27_RS09580	COG0247	lactate metabolic process
EXW27_RS09590	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW27_RS09595	COG0531	amino acid
EXW27_RS09610	COG4473	ABC transporter
EXW27_RS09615	COG1131	(ABC) transporter
EXW27_RS09620	COG0537	adenosine 5'-monophosphoramidase activity
EXW27_RS09630	COG1846	Transcriptional regulator
EXW27_RS09645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW27_RS09650	COG3973	AAA domain
EXW27_RS09665	COG1595	DNA-templated transcription, initiation
EXW27_RS09685	COG1695	Transcriptional regulator
EXW27_RS09690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW27_RS09695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW27_RS09700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW27_RS09705	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW27_RS09710	COG3620	sequence-specific DNA binding
EXW27_RS09715	COG2140	Oxalate decarboxylase
EXW27_RS09725	COG2267	carboxylic ester hydrolase activity
EXW27_RS09735	COG0457	Tetratricopeptide repeat
EXW27_RS09740	COG0346	lactoylglutathione lyase activity
EXW27_RS09745	COG0346	lactoylglutathione lyase activity
EXW27_RS09755	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW27_RS09760	COG4717	serine-type aminopeptidase activity
EXW27_RS09765	COG0420	3'-5' exonuclease activity
EXW27_RS09795	COG2197	response regulator
EXW27_RS09800	COG4585	Histidine kinase
EXW27_RS09810	COG2186	Transcriptional regulator
EXW27_RS09815	COG2807	transmembrane transport
EXW27_RS09845	COG2205	protein histidine kinase activity
EXW27_RS09845	COG0784	Response regulator, receiver
EXW27_RS09845	COG5002	protein histidine kinase activity
EXW27_RS09850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW27_RS09855	COG2208	phosphoserine phosphatase activity
EXW27_RS09865	COG1191	sigma factor activity
EXW27_RS09870	COG2172	sigma factor antagonist activity
EXW27_RS09890	COG3237	CsbD-like
EXW27_RS09910	COG0825	malonyl-CoA metabolic process
EXW27_RS09920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EXW27_RS09920	COG3266	domain, Protein
EXW27_RS09920	COG4932	domain protein
EXW27_RS09925	COG2318	DinB family
EXW27_RS09930	COG2378	regulation of single-species biofilm formation
EXW27_RS09945	COG0582	viral genome integration into host DNA
EXW27_RS09955	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS09955	COG4085	toxin activity
EXW27_RS09955	COG1525	nuclease
EXW27_RS09975	COG0076	glutamate decarboxylase activity
EXW27_RS09995	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS10000	COG1335	isochorismatase
EXW27_RS10015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW27_RS10030	COG2376	Dihydroxyacetone kinase
EXW27_RS10040	COG2376	Dihydroxyacetone kinase
EXW27_RS10060	COG0640	Transcriptional regulator
EXW27_RS10065	COG2814	Major facilitator Superfamily
EXW27_RS10125	COG1183	phosphatidylcholine synthase activity
EXW27_RS10135	COG0456	acetyltransferase
EXW27_RS10140	COG2723	6-phospho-beta-galactosidase activity
EXW27_RS10145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS10145	COG2190	(PTS) system
EXW27_RS10145	COG1263	PTS System
EXW27_RS10150	COG3711	transcriptional antiterminator
EXW27_RS10185	COG0477	Major facilitator Superfamily
EXW27_RS10215	COG0305	Participates in initiation and elongation during chromosome replication
EXW27_RS10240	COG3181	Tripartite tricarboxylate transporter family receptor
EXW27_RS10245	COG4565	transcriptional regulatory protein
EXW27_RS10250	COG3290	protein histidine kinase activity
EXW27_RS10255	COG0477	Major facilitator Superfamily
EXW27_RS10410	COG4608	Belongs to the ABC transporter superfamily
EXW27_RS10415	COG0444	Belongs to the ABC transporter superfamily
EXW27_RS10420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW27_RS10425	COG0601	transmembrane transport
EXW27_RS10460	COG0579	oxidoreductase
EXW27_RS10480	COG2318	DinB family
EXW27_RS10490	COG2801	Transposase and inactivated derivatives
EXW27_RS10505	COG1363	Peptidase, m42
EXW27_RS10520	COG1024	Enoyl-CoA hydratase
EXW27_RS10535	COG1696	Membrane protein involved in D-alanine export
EXW27_RS10555	COG2244	polysaccharide biosynthetic process
EXW27_RS10565	COG0659	secondary active sulfate transmembrane transporter activity
EXW27_RS10575	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS10580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW27_RS10590	COG0561	phosphatase activity
EXW27_RS10595	COG2094	Belongs to the DNA glycosylase MPG family
EXW27_RS10600	COG1216	Glycosyl transferase, family 2
EXW27_RS10605	COG0463	Glycosyl transferase, family 2
EXW27_RS10610	COG3527	Alpha-acetolactate decarboxylase
EXW27_RS10615	COG0028	Belongs to the TPP enzyme family
EXW27_RS10630	COG2801	Transposase and inactivated derivatives
EXW27_RS10640	COG3679	Belongs to the UPF0342 family
EXW27_RS10645	COG4399	Belongs to the UPF0754 family
EXW27_RS10655	COG0189	ligase activity
EXW27_RS10675	COG1126	abc transporter atp-binding protein
EXW27_RS10680	COG0765	amino acid transport
EXW27_RS10685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS10690	COG1132	(ABC) transporter
EXW27_RS10695	COG1132	(ABC) transporter
EXW27_RS10705	COG0531	amino acid
EXW27_RS10720	COG2814	Major facilitator Superfamily
EXW27_RS10725	COG4533	DNA binding
EXW27_RS10735	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW27_RS10745	COG1733	regulation of RNA biosynthetic process
EXW27_RS10750	COG2814	Major facilitator Superfamily
EXW27_RS10755	COG1309	transcriptional regulator
EXW27_RS10760	COG2076	Multidrug Resistance protein
EXW27_RS10775	COG0300	oxidoreductase activity
EXW27_RS10785	COG1522	sequence-specific DNA binding
EXW27_RS10790	COG0697	spore germination
EXW27_RS10810	COG2259	Doxx family
EXW27_RS10820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS10820	COG1263	PTS System
EXW27_RS10825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW27_RS10830	COG1737	Transcriptional regulator
EXW27_RS10840	COG0475	glutathione-regulated potassium exporter activity
EXW27_RS10845	COG0531	amino acid
EXW27_RS10875	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS10905	COG3546	catalase activity
EXW27_RS10910	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS10925	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW27_RS10935	COG1136	(ABC) transporter
EXW27_RS10940	COG0577	efflux transmembrane transporter activity
EXW27_RS10945	COG3584	3D domain protein
EXW27_RS10945	COG1388	LysM domain
EXW27_RS10970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW27_RS10975	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW27_RS10980	COG3711	transcriptional antiterminator
EXW27_RS10980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW27_RS10990	COG2814	Major facilitator Superfamily
EXW27_RS10995	COG0604	alcohol dehydrogenase
EXW27_RS11000	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW27_RS11005	COG0604	alcohol dehydrogenase
EXW27_RS11010	COG1316	TRANSCRIPTIONal
EXW27_RS11020	COG0730	response to heat
EXW27_RS11025	COG2210	Belongs to the sulfur carrier protein TusA family
EXW27_RS11030	COG0425	Belongs to the sulfur carrier protein TusA family
EXW27_RS11030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS11035	COG0425	Belongs to the sulfur carrier protein TusA family
EXW27_RS11040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS11040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS11045	COG0425	Belongs to the sulfur carrier protein TusA family
EXW27_RS11045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS11050	COG1937	Protein conserved in bacteria
EXW27_RS11070	COG2719	SpoVR family
EXW27_RS11075	COG0778	Nitroreductase
EXW27_RS11125	COG1609	Transcriptional regulator
EXW27_RS11130	COG1263	PTS System
EXW27_RS11130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS11135	COG1621	beta-fructofuranosidase activity
EXW27_RS11140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW27_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS11160	COG2252	PERMEase
EXW27_RS11165	COG1879	ABC-type sugar transport system periplasmic component
EXW27_RS11170	COG1129	ABC transporter
EXW27_RS11175	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW27_RS11195	COG1846	Transcriptional regulator
EXW27_RS11200	COG2814	Major facilitator Superfamily
EXW27_RS11205	COG2205	protein histidine kinase activity
EXW27_RS11210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW27_RS11215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW27_RS11220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW27_RS11245	COG0351	phosphomethylpyrimidine kinase
EXW27_RS11250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW27_RS11255	COG2022	thiamine diphosphate biosynthetic process
EXW27_RS11260	COG2104	thiamine diphosphate biosynthetic process
EXW27_RS11265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW27_RS11270	COG0352	thiamine-phosphate diphosphorylase activity
EXW27_RS11275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW27_RS11280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW27_RS11285	COG1116	anion transmembrane transporter activity
EXW27_RS11290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW27_RS11295	COG4991	sh3 domain protein
EXW27_RS11295	COG3103	Sh3 type 3 domain protein
EXW27_RS11295	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS11310	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW27_RS11430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW27_RS11440	COG0581	inorganic phosphate transmembrane transporter activity
EXW27_RS11445	COG0573	inorganic phosphate transmembrane transporter activity
EXW27_RS11450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW27_RS11460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW27_RS11465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW27_RS11475	COG0531	amino acid
EXW27_RS11480	COG0697	spore germination
EXW27_RS11485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW27_RS11500	COG4990	cell redox homeostasis
EXW27_RS11505	COG0833	amino acid
EXW27_RS11515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW27_RS11520	COG1845	cytochrome c oxidase, subunit III
EXW27_RS11530	COG0475	glutathione-regulated potassium exporter activity
EXW27_RS11530	COG0569	domain protein
EXW27_RS11540	COG2153	protein acetylation
EXW27_RS11555	COG2252	PERMEase
EXW27_RS11560	COG1113	amino acid transport
EXW27_RS11575	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS11580	COG3104	oligopeptide transport
EXW27_RS11600	COG1476	TRANSCRIPTIONal
EXW27_RS11605	COG3584	3D domain protein
EXW27_RS11605	COG3583	domain protein
EXW27_RS11610	COG0840	transmembrane signaling receptor activity
EXW27_RS11640	COG3568	Endonuclease Exonuclease Phosphatase
EXW27_RS11655	COG1063	alcohol dehydrogenase
EXW27_RS11685	COG1879	ABC-type sugar transport system periplasmic component
EXW27_RS11690	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW27_RS11700	COG1869	D-ribose catabolic process
EXW27_RS11705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW27_RS11710	COG1609	Transcriptional regulator
EXW27_RS11715	COG0477	Major facilitator Superfamily
EXW27_RS11720	COG1846	Transcriptional regulator
EXW27_RS11725	COG2271	Major facilitator Superfamily
EXW27_RS11740	COG0659	secondary active sulfate transmembrane transporter activity
EXW27_RS11755	COG5002	protein histidine kinase activity
EXW27_RS11760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW27_RS11765	COG2378	regulation of single-species biofilm formation
EXW27_RS11775	COG0833	amino acid
EXW27_RS11780	COG0765	amino acid transport
EXW27_RS11785	COG0765	amino acid transport
EXW27_RS11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS11795	COG1126	abc transporter atp-binding protein
EXW27_RS11800	COG1115	amino acid carrier protein
EXW27_RS11805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW27_RS11820	COG1404	Belongs to the peptidase S8 family
EXW27_RS11825	COG2197	response regulator
EXW27_RS11830	COG4585	Histidine kinase
EXW27_RS11835	COG0697	spore germination
EXW27_RS11850	COG0366	Alpha amylase catalytic
EXW27_RS11855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS11855	COG1263	PTS System
EXW27_RS11860	COG2188	Transcriptional regulator
EXW27_RS11865	COG0531	amino acid
EXW27_RS11885	COG0714	Associated with various cellular activities
EXW27_RS11890	COG4548	von Willebrand factor, type A
EXW27_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW27_RS11905	COG0156	8-amino-7-oxononanoate synthase activity
EXW27_RS11920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS11925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS11930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS11935	COG3104	oligopeptide transport
EXW27_RS11950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS11955	COG1620	l-lactate permease
EXW27_RS11960	COG1027	Aspartate ammonia-lyase
EXW27_RS11965	COG1253	flavin adenine dinucleotide binding
EXW27_RS11970	COG0346	lactoylglutathione lyase activity
EXW27_RS11975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS11980	COG1316	TRANSCRIPTIONal
EXW27_RS11985	COG2720	vancomycin resistance protein
EXW27_RS12005	COG3227	Zinc metalloprotease (Elastase)
EXW27_RS12020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW27_RS12025	COG2217	Heavy metal translocating P-type atpase
EXW27_RS12030	COG0640	Transcriptional regulator
EXW27_RS12040	COG0531	amino acid
EXW27_RS12055	COG2427	Protein of unknown function (DUF1641)
EXW27_RS12060	COG3383	formate dehydrogenase (NAD+) activity
EXW27_RS12065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW27_RS12070	COG0456	acetyltransferase
EXW27_RS12075	COG0745	RESPONSE REGULATOR receiver
EXW27_RS12080	COG5002	protein histidine kinase activity
EXW27_RS12090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS12095	COG0697	spore germination
EXW27_RS12105	COG0281	malic enzyme
EXW27_RS12110	COG3493	citrate carrier protein
EXW27_RS12115	COG4565	transcriptional regulatory protein
EXW27_RS12120	COG3290	protein histidine kinase activity
EXW27_RS12130	COG4990	cell redox homeostasis
EXW27_RS12140	COG5002	protein histidine kinase activity
EXW27_RS12145	COG0745	RESPONSE REGULATOR receiver
EXW27_RS12150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW27_RS12160	COG0395	ABC-type sugar transport system, permease component
EXW27_RS12165	COG1175	transmembrane transport
EXW27_RS12170	COG3842	ATPase activity
EXW27_RS12175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW27_RS12200	COG2851	Citrate transporter
EXW27_RS12205	COG4565	transcriptional regulatory protein
EXW27_RS12210	COG3290	protein histidine kinase activity
EXW27_RS12220	COG2268	Band 7 protein
EXW27_RS12225	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW27_RS12240	COG2718	Belongs to the UPF0229 family
EXW27_RS12245	COG2766	serine protein kinase
EXW27_RS12255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW27_RS12275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW27_RS12280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW27_RS12400	COG0735	belongs to the Fur family
EXW27_RS12405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW27_RS12425	COG4555	ABC transporter
EXW27_RS12430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW27_RS12435	COG0070	glutamate synthase
EXW27_RS12435	COG0067	glutamate synthase
EXW27_RS12435	COG0069	glutamate synthase activity
EXW27_RS12440	COG4129	membrane
EXW27_RS12445	COG1132	(ABC) transporter
EXW27_RS12450	COG3557	Belongs to the UPF0374 family
EXW27_RS12470	COG1194	a g-specific adenine glycosylase
EXW27_RS12475	COG1988	membrane-bound metal-dependent
EXW27_RS12500	COG2137	regulation of response to DNA damage stimulus
EXW27_RS12505	COG1090	epimerase
EXW27_RS12510	COG1228	amidohydrolase
EXW27_RS12525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW27_RS12530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW27_RS12545	COG0463	Glycosyl transferase, family 2
EXW27_RS12550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW27_RS12550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW27_RS12560	COG1216	Glycosyl transferase, family 2
EXW27_RS12580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW27_RS12585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS12585	COG1263	PTS System
EXW27_RS12590	COG2066	Belongs to the glutaminase family
EXW27_RS12610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW27_RS12615	COG0833	amino acid
EXW27_RS12625	COG3829	transcription factor binding
EXW27_RS12645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW27_RS12665	COG0535	radical SAM domain protein
EXW27_RS12675	COG0387	Pfam Sodium calcium exchanger
EXW27_RS12680	COG3871	stress protein (general stress protein 26)
EXW27_RS12695	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS12715	COG0697	spore germination
EXW27_RS12720	COG2217	Heavy metal translocating P-type atpase
EXW27_RS12725	COG1295	ribonuclease BN
EXW27_RS12735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW27_RS12740	COG4840	Belongs to the UPF0435 family
EXW27_RS12750	COG3853	Toxic anion resistance protein (TelA)
EXW27_RS12760	COG0861	Integral membrane protein TerC family
EXW27_RS12765	COG2310	stress, protein
EXW27_RS12770	COG2310	stress, protein
EXW27_RS12775	COG2310	stress, protein
EXW27_RS12805	COG2270	Major facilitator Superfamily
EXW27_RS12850	COG0488	(ABC) transporter
EXW27_RS12855	COG1116	anion transmembrane transporter activity
EXW27_RS12860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW27_RS12865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW27_RS12880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW27_RS12885	COG0352	thiamine-phosphate diphosphorylase activity
EXW27_RS12890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW27_RS12905	COG2801	Transposase and inactivated derivatives
EXW27_RS12920	COG1263	PTS System
EXW27_RS12920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS12920	COG2190	(PTS) system
EXW27_RS12925	COG0366	Alpha amylase catalytic
EXW27_RS12930	COG0277	FAD linked oxidase domain protein
EXW27_RS12935	COG0840	transmembrane signaling receptor activity
EXW27_RS12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS12950	COG0765	amino acid transport
EXW27_RS12960	COG0723	plastoquinol--plastocyanin reductase activity
EXW27_RS12960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW27_RS12965	COG2814	Major facilitator Superfamily
EXW27_RS12970	COG3541	Predicted nucleotidyltransferase
EXW27_RS12990	COG5002	protein histidine kinase activity
EXW27_RS13015	COG0166	Belongs to the GPI family
EXW27_RS13025	COG0492	ferredoxin-NADP+ reductase activity
EXW27_RS13030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS13035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS13040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS13050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW27_RS13060	COG0450	alkyl hydroperoxide reductase
EXW27_RS13075	COG1473	amidohydrolase
EXW27_RS13080	COG1757	Na H antiporter
EXW27_RS13105	COG4807	Protein conserved in bacteria
EXW27_RS13110	COG5002	protein histidine kinase activity
EXW27_RS13115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW27_RS13125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS13140	COG2309	aminopeptidase activity
EXW27_RS13145	COG2076	Multidrug Resistance protein
EXW27_RS13150	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS13160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS13165	COG0546	phosphoglycolate phosphatase activity
EXW27_RS13170	COG1597	lipid kinase activity
EXW27_RS13175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW27_RS13180	COG0154	amidase activity
EXW27_RS13190	COG4682	membrane
EXW27_RS13195	COG1846	Transcriptional regulator
EXW27_RS13200	COG0003	Pfam Anion-transporting ATPase
EXW27_RS13215	COG1464	Belongs to the NlpA lipoprotein family
EXW27_RS13220	COG2011	ABC-type metal ion transport system permease component
EXW27_RS13230	COG1335	isochorismatase
EXW27_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS13245	COG4851	CamS sex pheromone cAM373 precursor
EXW27_RS13250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW27_RS13255	COG0210	DNA helicase
EXW27_RS13260	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW27_RS13280	COG0151	Belongs to the GarS family
EXW27_RS13285	COG0138	bifunctional purine biosynthesis protein purh
EXW27_RS13290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW27_RS13295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW27_RS13300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW27_RS13305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW27_RS13310	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW27_RS13315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW27_RS13320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW27_RS13325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW27_RS13330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW27_RS13335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW27_RS13360	COG0697	spore germination
EXW27_RS13380	COG0745	RESPONSE REGULATOR receiver
EXW27_RS13385	COG2205	protein histidine kinase activity
EXW27_RS13450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW27_RS13470	COG5002	protein histidine kinase activity
EXW27_RS13480	COG2252	PERMEase
EXW27_RS13485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW27_RS13485	COG0519	Catalyzes the synthesis of GMP from XMP
EXW27_RS13490	COG0459	protein refolding
EXW27_RS13495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW27_RS13500	COG1266	CAAX protease self-immunity
EXW27_RS13510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW27_RS13515	COG0488	(ABC) transporter
EXW27_RS13525	COG0456	acetyltransferase
EXW27_RS13530	COG1214	PFAM Peptidase M22, glycoprotease
EXW27_RS13535	COG0802	atpase or kinase
EXW27_RS13635	COG2183	response to ionizing radiation
EXW27_RS13640	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW27_RS13645	COG0864	Transcriptional regulator
EXW27_RS13655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW27_RS13660	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW27_RS13665	COG0705	Rhomboid family
EXW27_RS13670	COG4294	response to UV
EXW27_RS13680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW27_RS13690	COG2814	Major facilitator Superfamily
EXW27_RS13695	COG0531	amino acid
EXW27_RS13705	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW27_RS13710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW27_RS13745	COG0561	phosphatase activity
EXW27_RS13750	COG4608	Belongs to the ABC transporter superfamily
EXW27_RS13755	COG0444	Belongs to the ABC transporter superfamily
EXW27_RS13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW27_RS13765	COG0601	transmembrane transport
EXW27_RS13775	COG0747	negative chemotaxis
EXW27_RS13785	COG0842	Transport permease protein
EXW27_RS13790	COG0842	Transport permease protein
EXW27_RS13790	COG1511	domain protein
EXW27_RS13795	COG1131	(ABC) transporter
EXW27_RS13800	COG2197	response regulator
EXW27_RS13805	COG4585	Histidine kinase
EXW27_RS13810	COG0488	(ABC) transporter
EXW27_RS13830	COG5298	Protein conserved in bacteria
EXW27_RS13845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS13855	COG1609	Transcriptional regulator
EXW27_RS13865	COG0204	Acyl-transferase
EXW27_RS13880	COG0697	spore germination
EXW27_RS13895	COG1910	domain protein
EXW27_RS13900	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW27_RS13905	COG4149	molybdate abc transporter
EXW27_RS13920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW27_RS13925	COG0656	L-ascorbic acid biosynthetic process
EXW27_RS13930	COG4166	transmembrane transport
EXW27_RS13935	COG4166	transmembrane transport
EXW27_RS13950	COG2207	Transcriptional regulator
EXW27_RS13960	COG4166	transmembrane transport
EXW27_RS13965	COG4608	Belongs to the ABC transporter superfamily
EXW27_RS13970	COG0444	Belongs to the ABC transporter superfamily
EXW27_RS13975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW27_RS13980	COG0601	transmembrane transport
EXW27_RS14000	COG2814	Major facilitator Superfamily
EXW27_RS14010	COG2271	Major facilitator Superfamily
EXW27_RS14015	COG0277	FAD linked oxidase domain protein
EXW27_RS14025	COG0604	alcohol dehydrogenase
EXW27_RS14030	COG1464	Belongs to the NlpA lipoprotein family
EXW27_RS14040	COG2011	ABC-type metal ion transport system permease component
EXW27_RS14045	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS14070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW27_RS14075	COG4856	YbbR-like protein
EXW27_RS14080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW27_RS14160	COG0726	polysaccharide deacetylase
EXW27_RS14165	COG2194	sulfuric ester hydrolase activity
EXW27_RS14175	COG0489	protein tyrosine kinase activity
EXW27_RS14180	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS14190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW27_RS14195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW27_RS14205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW27_RS14230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW27_RS14235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW27_RS14240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW27_RS14250	COG0024	Methionine aminopeptidase
EXW27_RS14255	COG0563	adenylate kinase activity
EXW27_RS14260	COG0201	protein transport
EXW27_RS14265	COG0200	Binds to the 23S rRNA
EXW27_RS14270	COG1841	ribosomal large subunit assembly
EXW27_RS14280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW27_RS14290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW27_RS14300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW27_RS14305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW27_RS14315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW27_RS14320	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW27_RS14335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW27_RS14340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW27_RS14345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW27_RS14350	COG0089	rRNA binding
EXW27_RS14355	COG0088	Forms part of the polypeptide exit tunnel
EXW27_RS14360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW27_RS14365	COG0051	transcription antitermination factor activity, RNA binding
EXW27_RS14370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW27_RS14375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW27_RS14385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW27_RS14390	COG1358	cellular component organization or biogenesis
EXW27_RS14395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW27_RS14400	COG0085	RNA polymerase activity
EXW27_RS14405	COG2813	Specifically methylates the guanine in position
EXW27_RS14410	COG0222	ribosome binding
EXW27_RS14415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW27_RS14420	COG0081	regulation of translation
EXW27_RS14425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW27_RS14430	COG0250	Participates in transcription elongation, termination and antitermination
EXW27_RS14435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW27_RS14440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW27_RS14450	COG3688	RNA-binding protein containing a PIN domain
EXW27_RS14455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW27_RS14465	COG0215	cysteine-tRNA ligase activity
EXW27_RS14470	COG1045	serine acetyltransferase
EXW27_RS14475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW27_RS14485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW27_RS14490	COG4956	integral membrane protein (PIN domain superfamily)
EXW27_RS14495	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW27_RS14500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW27_RS14505	COG0542	response to heat
EXW27_RS14510	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW27_RS14515	COG3880	PFAM UvrB UvrC protein
EXW27_RS14600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW27_RS14605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW27_RS14610	COG1396	sequence-specific DNA binding
EXW27_RS14615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW27_RS14620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW27_RS14625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW27_RS14630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW27_RS14635	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW27_RS14640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW27_RS14645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW27_RS14650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW27_RS14655	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW27_RS14660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW27_RS14665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW27_RS14675	COG2208	phosphoserine phosphatase activity
EXW27_RS14690	COG1098	S1 RNA binding domain
EXW27_RS14710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW27_RS14715	COG3956	TIGRFAM MazG family protein
EXW27_RS14720	COG2244	polysaccharide biosynthetic process
EXW27_RS14725	COG2002	toxin-antitoxin pair type II binding
EXW27_RS14730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW27_RS14750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW27_RS14755	COG2088	sporulation resulting in formation of a cellular spore
EXW27_RS14760	COG0251	oxidation-reduction process
EXW27_RS14765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW27_RS14770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW27_RS14780	COG4466	Protein conserved in bacteria
EXW27_RS14790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW27_RS14800	COG0084	hydrolase, TatD family'
EXW27_RS14810	COG2002	toxin-antitoxin pair type II binding
EXW27_RS14815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW27_RS14825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW27_RS14830	COG4467	Involved in initiation control of chromosome replication
EXW27_RS14835	COG1774	PSP1 C-terminal conserved region
EXW27_RS14840	COG0470	DNA polymerase III
EXW27_RS14845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW27_RS14850	COG1982	Orn Lys Arg decarboxylase major
EXW27_RS14895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW27_RS14900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW27_RS14905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW27_RS14915	COG0590	tRNA wobble adenosine to inosine editing
EXW27_RS14920	COG1335	isochorismatase
EXW27_RS14925	COG1428	Deoxynucleoside kinase
EXW27_RS14930	COG1428	Deoxynucleoside kinase
EXW27_RS14950	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW27_RS14955	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW27_RS14960	COG1686	Belongs to the peptidase S11 family
EXW27_RS14965	COG0517	IMP dehydrogenase activity
EXW27_RS14965	COG0516	GMP reductase activity
EXW27_RS15000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW27_RS15005	COG0187	DNA topoisomerase II activity
EXW27_RS15010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW27_RS15015	COG2501	S4 domain
EXW27_RS15020	COG0592	DNA-directed DNA polymerase activity
EXW27_RS15025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW27_RS15030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW27_RS15035	COG0594	ribonuclease P activity
EXW27_RS15040	COG0706	membrane insertase activity
EXW27_RS15045	COG1847	R3H domain protein
EXW27_RS15050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW27_RS15055	COG0445	tRNA wobble uridine modification
EXW27_RS15060	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW27_RS15065	COG1475	DNA binding
EXW27_RS15070	COG1192	Involved in chromosome partitioning
EXW27_RS15075	COG1475	DNA binding
EXW27_RS15085	COG0668	transmembrane transport
EXW27_RS15090	COG4481	Protein conserved in bacteria
EXW27_RS15095	COG0012	GTP binding
EXW27_RS15100	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW27_RS15105	COG0629	single-stranded DNA binding
EXW27_RS15115	COG4241	membrane
EXW27_RS15120	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW27_RS15125	COG0359	binds to the 23S rRNA
EXW27_RS15130	COG0305	Participates in initiation and elongation during chromosome replication
EXW27_RS15160	COG0745	RESPONSE REGULATOR receiver
EXW27_RS15165	COG5002	protein histidine kinase activity
EXW27_RS15175	COG4853	Protein conserved in bacteria
EXW27_RS15180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW27_RS15185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW27_RS15195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW27_RS15205	COG1164	Oligoendopeptidase f
EXW27_RS15230	COG1272	protein, Hemolysin III
EXW27_RS15235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW27_RS15285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW27_RS15290	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW27_RS15295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW27_RS15300	COG2814	Major facilitator Superfamily
EXW27_RS15305	COG3275	phosphorelay sensor kinase activity
EXW27_RS15310	COG3279	Response regulator of the LytR AlgR family
EXW27_RS15315	COG1380	Effector of murein hydrolase LrgA
EXW27_RS15325	COG0628	permease
EXW27_RS15330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW27_RS15330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW27_RS15335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW27_RS15340	COG1309	transcriptional regulator
EXW27_RS15345	COG0488	(ABC) transporter
EXW27_RS15355	COG1216	Glycosyl transferase, family 2
EXW27_RS15370	COG1216	Glycosyl transferase, family 2
EXW27_RS15375	COG1607	acyl-coa hydrolase
EXW27_RS15385	COG0840	transmembrane signaling receptor activity
EXW27_RS15410	COG0477	Major facilitator Superfamily
EXW27_RS15415	COG3279	Response regulator of the LytR AlgR family
EXW27_RS15420	COG1966	Carbon starvation protein
EXW27_RS15425	COG2879	small protein
EXW27_RS15430	COG3706	GGDEF domain
EXW27_RS15435	COG0351	phosphomethylpyrimidine kinase
EXW27_RS15440	COG4585	Histidine kinase
EXW27_RS15440	COG2203	Gaf domain
EXW27_RS15445	COG2197	response regulator
EXW27_RS15460	COG2873	o-acetylhomoserine
EXW27_RS15465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW27_RS15470	COG0460	homoserine dehydrogenase
EXW27_RS15480	COG1609	Transcriptional regulator
EXW27_RS15485	COG2755	lipolytic protein G-D-S-L family
EXW27_RS15490	COG1131	(ABC) transporter
EXW27_RS15495	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW27_RS15500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW27_RS15505	COG2814	Major facilitator Superfamily
EXW27_RS15510	COG0561	phosphatase activity
EXW27_RS15515	COG2233	PERMEase
EXW27_RS15530	COG2363	Small membrane protein
EXW27_RS15540	COG3773	Cell wall hydrolase
EXW27_RS15550	COG3253	May function as heme-dependent peroxidase
EXW27_RS15555	COG0280	phosphate acetyltransferase
EXW27_RS15570	COG4844	belongs to the
EXW27_RS15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS15585	COG1120	ATPase activity
EXW27_RS15590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS15595	COG1078	dGTPase activity
EXW27_RS15605	COG1994	Peptidase M50
EXW27_RS15615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW27_RS15620	COG0584	glycerophosphoryl diester phosphodiesterase
EXW27_RS15625	COG0789	Transcriptional regulator
EXW27_RS15630	COG2814	Major facilitator Superfamily
EXW27_RS15635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW27_RS15640	COG0010	Belongs to the arginase family
EXW27_RS15655	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW27_RS15660	COG4506	Protein conserved in bacteria
EXW27_RS15675	COG2234	aminopeptidase activity
EXW27_RS15680	COG0024	Methionine aminopeptidase
EXW27_RS15685	COG1131	(ABC) transporter
EXW27_RS15690	COG0842	Transport permease protein
EXW27_RS15695	COG4585	Histidine kinase
EXW27_RS15700	COG2197	response regulator
EXW27_RS15705	COG3227	Zinc metalloprotease (Elastase)
EXW27_RS15720	COG3300	MHYT domain
EXW27_RS15720	COG5001	Diguanylate cyclase
EXW27_RS15725	COG4294	response to UV
EXW27_RS15730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW27_RS15735	COG0247	lactate metabolic process
EXW27_RS15735	COG2181	nitrate reductase activity
EXW27_RS15740	COG0183	Belongs to the thiolase family
EXW27_RS15745	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW27_RS15750	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS15755	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS15765	COG3343	RNA polymerase activity
EXW27_RS15770	COG0504	CTP synthase activity
EXW27_RS15775	COG4821	SIS domain
EXW27_RS15795	COG1494	fructose-1,6-bisphosphatase
EXW27_RS15800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW27_RS15810	COG1435	thymidine kinase activity
EXW27_RS15815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW27_RS15820	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW27_RS15835	COG0009	L-threonylcarbamoyladenylate synthase
EXW27_RS15840	COG1971	Probably functions as a manganese efflux pump
EXW27_RS15850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW27_RS15855	COG2259	Doxx family
EXW27_RS15860	COG2190	(PTS) system
EXW27_RS15870	COG0698	ribose 5-phosphate isomerase
EXW27_RS15880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW27_RS15905	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW27_RS15915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW27_RS15920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW27_RS15925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW27_RS15930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW27_RS15935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW27_RS15940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW27_RS15955	COG5001	Diguanylate cyclase
EXW27_RS15955	COG3300	MHYT domain
EXW27_RS15960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW27_RS15965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW27_RS15970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW27_RS15975	COG0649	NAD binding
EXW27_RS15980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW27_RS15990	COG0839	Belongs to the complex I subunit 6 family
EXW27_RS15995	COG0713	ATP synthesis coupled electron transport
EXW27_RS16000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW27_RS16005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW27_RS16010	COG1007	ATP synthesis coupled electron transport
EXW27_RS16015	COG4836	Membrane
EXW27_RS16030	COG2385	sporulation resulting in formation of a cellular spore
EXW27_RS16035	COG3279	Response regulator of the LytR AlgR family
EXW27_RS16050	COG0739	heme binding
EXW27_RS16060	COG1609	Transcriptional regulator
EXW27_RS16075	COG0489	protein tyrosine kinase activity
EXW27_RS16080	COG3944	biosynthesis protein
EXW27_RS16085	COG0489	protein tyrosine kinase activity
EXW27_RS16090	COG4464	protein tyrosine phosphatase activity
EXW27_RS16095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW27_RS16120	COG1215	transferase activity, transferring glycosyl groups
EXW27_RS16125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW27_RS16130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW27_RS16135	COG1316	TRANSCRIPTIONal
EXW27_RS16145	COG0745	RESPONSE REGULATOR receiver
EXW27_RS16150	COG3850	Histidine kinase
EXW27_RS16150	COG5002	protein histidine kinase activity
EXW27_RS16175	COG1136	(ABC) transporter
EXW27_RS16180	COG0577	efflux transmembrane transporter activity
EXW27_RS16220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW27_RS16225	COG4715	Zinc finger, swim domain protein
EXW27_RS16250	COG3584	3D domain protein
EXW27_RS16250	COG1388	LysM domain
EXW27_RS16255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW27_RS16260	COG1215	transferase activity, transferring glycosyl groups
EXW27_RS16270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS16275	COG1388	LysM domain
EXW27_RS16275	COG0791	NLP P60 protein
EXW27_RS16285	COG1368	sulfuric ester hydrolase activity
EXW27_RS16295	COG2389	metal-binding protein
EXW27_RS16305	COG1620	l-lactate permease
EXW27_RS16315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW27_RS16320	COG1294	oxidase, subunit
EXW27_RS16325	COG1271	oxidase subunit
EXW27_RS16335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW27_RS16340	COG0583	DNA-binding transcription factor activity
EXW27_RS16345	COG1511	domain protein
EXW27_RS16360	COG1301	dicarboxylic acid transport
EXW27_RS16365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW27_RS16375	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW27_RS16395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW27_RS16400	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW27_RS16405	COG1486	melibiose metabolic process
EXW27_RS16425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW27_RS16425	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW27_RS16435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW27_RS16440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW27_RS16445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW27_RS16450	COG1316	TRANSCRIPTIONal
EXW27_RS16455	COG1739	Uncharacterized protein family UPF0029
EXW27_RS16460	COG1307	EDD domain protein, DegV family
EXW27_RS16465	COG1733	regulation of RNA biosynthetic process
EXW27_RS16475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW27_RS16480	COG1040	competence protein
EXW27_RS16485	COG1278	Cold shock
EXW27_RS16520	COG1131	(ABC) transporter
EXW27_RS16545	COG2884	Cell division ATP-binding protein ftsE
EXW27_RS16550	COG2177	Part of the ABC transporter FtsEX involved in
EXW27_RS16555	COG0793	Belongs to the peptidase S41A family
EXW27_RS16555	COG3409	Peptidoglycan-binding domain 1 protein
EXW27_RS16560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW27_RS16565	COG1132	(ABC) transporter
EXW27_RS16575	COG0488	(ABC) transporter
EXW27_RS16580	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW27_RS16585	COG0789	Transcriptional regulator
EXW27_RS16590	COG0583	DNA-binding transcription factor activity
EXW27_RS16625	COG0789	Transcriptional regulator
EXW27_RS16645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW27_RS16650	COG1950	PFAM Membrane protein of
EXW27_RS16655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW27_RS16660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW27_RS16665	COG0546	phosphoglycolate phosphatase activity
EXW27_RS16670	COG0110	maltose O-acetyltransferase activity
EXW27_RS16675	COG0457	Tetratricopeptide repeat
EXW27_RS16680	COG0492	ferredoxin-NADP+ reductase activity
EXW27_RS16690	COG1051	belongs to the nudix hydrolase family
EXW27_RS16695	COG1660	Displays ATPase and GTPase activities
EXW27_RS16700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW27_RS16705	COG1481	regulation of sporulation
EXW27_RS16710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW27_RS16720	COG2323	membrane
EXW27_RS16735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW27_RS16775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW27_RS16790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW27_RS16795	COG0126	phosphoglycerate kinase activity
EXW27_RS16800	COG0149	triose-phosphate isomerase activity
EXW27_RS16810	COG0148	phosphopyruvate hydratase activity
EXW27_RS16825	COG1346	cytolysis
EXW27_RS16830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW27_RS16835	COG1647	Serine aminopeptidase, S33
EXW27_RS16840	COG0557	exoribonuclease II activity
EXW27_RS16845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW27_RS16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS16890	COG2233	PERMEase
EXW27_RS16895	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW27_RS16900	COG0288	reversible hydration of carbon dioxide
EXW27_RS16905	COG1522	sequence-specific DNA binding
EXW27_RS16915	COG1522	sequence-specific DNA binding
EXW27_RS16920	COG1335	isochorismatase
EXW27_RS16925	COG4224	UPF0291 protein
EXW27_RS16930	COG0778	Nitroreductase
EXW27_RS16935	COG1733	regulation of RNA biosynthetic process
EXW27_RS16945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS16950	COG0488	(ABC) transporter
EXW27_RS16980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW27_RS16990	COG0840	transmembrane signaling receptor activity
EXW27_RS16990	COG3290	protein histidine kinase activity
EXW27_RS17010	COG1252	NADH dehydrogenase
EXW27_RS17020	COG1733	regulation of RNA biosynthetic process
EXW27_RS17025	COG2814	Major facilitator Superfamily
EXW27_RS17030	COG0656	L-ascorbic acid biosynthetic process
EXW27_RS17040	COG2910	NAD(P)H-binding
EXW27_RS17045	COG1115	amino acid carrier protein
EXW27_RS17050	COG1115	amino acid carrier protein
EXW27_RS17055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS17060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW27_RS17070	COG1528	Iron-storage protein
EXW27_RS17080	COG1611	Belongs to the LOG family
EXW27_RS17085	COG2318	DinB family
EXW27_RS17095	COG0783	Belongs to the Dps family
EXW27_RS17100	COG1115	amino acid carrier protein
EXW27_RS17105	COG0490	domain, Protein
EXW27_RS17110	COG0475	glutathione-regulated potassium exporter activity
EXW27_RS17115	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS17130	COG1741	Belongs to the pirin family
EXW27_RS17135	COG3227	Zinc metalloprotease (Elastase)
EXW27_RS17140	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW27_RS17145	COG0840	transmembrane signaling receptor activity
EXW27_RS17150	COG0840	transmembrane signaling receptor activity
EXW27_RS17160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW27_RS17170	COG5002	protein histidine kinase activity
EXW27_RS17175	COG0745	RESPONSE REGULATOR receiver
EXW27_RS17180	COG1376	ErfK ybiS ycfS ynhG family protein
EXW27_RS17190	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS17220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS17245	COG0531	amino acid
EXW27_RS17250	COG2814	Major facilitator Superfamily
EXW27_RS17265	COG0840	transmembrane signaling receptor activity
EXW27_RS17270	COG0011	TIGRFAM Protein of
EXW27_RS17280	COG0506	proline dehydrogenase activity
EXW27_RS17285	COG1686	Belongs to the peptidase S11 family
EXW27_RS17295	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW27_RS17295	COG1024	Enoyl-CoA hydratase
EXW27_RS17300	COG0183	Belongs to the thiolase family
EXW27_RS17305	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS17320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS17360	COG1393	Belongs to the ArsC family
EXW27_RS17365	COG0509	glycine decarboxylation via glycine cleavage system
EXW27_RS17370	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW27_RS17375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS17385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW27_RS17390	COG2011	ABC-type metal ion transport system permease component
EXW27_RS17395	COG1464	Belongs to the NlpA lipoprotein family
EXW27_RS17400	COG1464	Belongs to the NlpA lipoprotein family
EXW27_RS17405	COG0396	ATPase activity
EXW27_RS17410	COG0719	Fe-S assembly protein
EXW27_RS17415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW27_RS17420	COG0822	iron-sulfur transferase activity
EXW27_RS17425	COG0719	Fe-S assembly protein
EXW27_RS17435	COG1695	Transcriptional regulator
EXW27_RS17440	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS17445	COG3377	Domain of unknown function (DUF1805)
EXW27_RS17455	COG0739	heme binding
EXW27_RS17460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW27_RS17480	COG4377	Putative membrane peptidase family (DUF2324)
EXW27_RS17485	COG0789	Transcriptional regulator
EXW27_RS17495	COG4470	Protein conserved in bacteria
EXW27_RS17510	COG1494	fructose-1,6-bisphosphatase
EXW27_RS17515	COG2445	Protein of unknown function DUF86
EXW27_RS17525	COG0647	UMP catabolic process
EXW27_RS17535	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW27_RS17540	COG1136	(ABC) transporter
EXW27_RS17540	COG0577	efflux transmembrane transporter activity
EXW27_RS17555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW27_RS17560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW27_RS17570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW27_RS17575	COG4837	Protein of unknown function (DUF1462)
EXW27_RS17605	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW27_RS17610	COG0390	transport system, permease component
EXW27_RS17620	COG1252	NADH dehydrogenase
EXW27_RS17625	COG4844	belongs to the
EXW27_RS17630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW27_RS17635	COG0316	Belongs to the HesB IscA family
EXW27_RS17655	COG1683	Conserved Protein
EXW27_RS17670	COG3708	Transcriptional regulator
EXW27_RS17675	COG0492	ferredoxin-NADP+ reductase activity
EXW27_RS17680	COG1252	NADH dehydrogenase
EXW27_RS17695	COG3584	3D domain protein
EXW27_RS17700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW27_RS17710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW27_RS17715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW27_RS17725	COG1268	BioY protein
EXW27_RS17735	COG2050	protein possibly involved in aromatic compounds catabolism
EXW27_RS17755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW27_RS17760	COG5018	Exonuclease
EXW27_RS17780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW27_RS17790	COG2267	carboxylic ester hydrolase activity
EXW27_RS17795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW27_RS17800	COG1522	sequence-specific DNA binding
EXW27_RS17805	COG0436	Aminotransferase
EXW27_RS17810	COG1098	S1 RNA binding domain
EXW27_RS17815	COG2155	Conserved Protein
EXW27_RS17820	COG0166	Belongs to the GPI family
EXW27_RS17830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW27_RS17835	COG1285	pathogenesis
EXW27_RS17985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW27_RS17990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW27_RS17995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW27_RS18005	COG0058	SHG alpha-glucan phosphorylase activity
EXW27_RS18015	COG0789	Transcriptional regulator
EXW27_RS18025	COG1278	Cold shock
EXW27_RS18030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW27_RS18035	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW27_RS18040	COG1169	isochorismate synthase
EXW27_RS18045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW27_RS18055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW27_RS18065	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS18070	COG4948	Mandelate Racemase Muconate Lactonizing
EXW27_RS18090	COG3964	amidohydrolase
EXW27_RS18110	COG2188	Transcriptional regulator
EXW27_RS18125	COG0577	efflux transmembrane transporter activity
EXW27_RS18130	COG1136	(ABC) transporter
EXW27_RS18135	COG0577	efflux transmembrane transporter activity
EXW27_RS18140	COG0577	efflux transmembrane transporter activity
EXW27_RS18145	COG2205	protein histidine kinase activity
EXW27_RS18150	COG0745	RESPONSE REGULATOR receiver
EXW27_RS18155	COG0640	Transcriptional regulator
EXW27_RS18160	COG5658	integral membrane protein
EXW27_RS18165	COG1131	(ABC) transporter
EXW27_RS18175	COG3708	Transcriptional regulator
EXW27_RS18175	COG2207	Transcriptional regulator
EXW27_RS18180	COG1136	(ABC) transporter
EXW27_RS18185	COG0577	efflux transmembrane transporter activity
EXW27_RS18200	COG0586	Pfam SNARE associated Golgi protein
EXW27_RS18210	COG5002	protein histidine kinase activity
EXW27_RS18240	COG1136	(ABC) transporter
EXW27_RS18255	COG1597	lipid kinase activity
EXW27_RS18260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW27_RS18285	COG0745	RESPONSE REGULATOR receiver
EXW27_RS18290	COG5002	protein histidine kinase activity
EXW27_RS18295	COG3859	Proton-coupled thiamine transporter YuaJ
EXW27_RS18320	COG1842	Phage shock protein A
EXW27_RS18340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS18360	COG1294	oxidase, subunit
EXW27_RS18365	COG1271	oxidase subunit
EXW27_RS18370	COG0288	reversible hydration of carbon dioxide
EXW27_RS18380	COG1854	S-ribosylhomocysteine lyase activity
EXW27_RS18385	COG0789	Transcriptional regulator
EXW27_RS18400	COG2211	Major facilitator Superfamily
EXW27_RS18410	COG2076	Multidrug Resistance protein
EXW27_RS18415	COG2076	Multidrug Resistance protein
EXW27_RS18450	COG0494	nUDIX hydrolase
EXW27_RS18475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW27_RS18480	COG1116	anion transmembrane transporter activity
EXW27_RS18485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW27_RS18500	COG4895	conserved protein (DUF2196)
EXW27_RS18510	COG1368	sulfuric ester hydrolase activity
EXW27_RS18520	COG2267	carboxylic ester hydrolase activity
EXW27_RS18525	COG0753	catalase activity
EXW27_RS18530	COG3852	Histidine kinase
EXW27_RS18535	COG5002	protein histidine kinase activity
EXW27_RS18570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW27_RS18575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW27_RS18595	COG0746	molybdenum cofactor guanylyltransferase activity
EXW27_RS18610	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS18615	COG0671	phosphoesterase, PA-phosphatase related
EXW27_RS18620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW27_RS18625	COG2267	carboxylic ester hydrolase activity
EXW27_RS18640	COG1794	racemase activity, acting on amino acids and derivatives
EXW27_RS18650	COG1131	(ABC) transporter
EXW27_RS18655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW27_RS18660	COG1242	4 iron, 4 sulfur cluster binding
EXW27_RS18675	COG1136	(ABC) transporter
EXW27_RS18685	COG0582	viral genome integration into host DNA
EXW27_RS18690	COG0490	domain, Protein
EXW27_RS18695	COG0475	glutathione-regulated potassium exporter activity
EXW27_RS18700	COG2814	Major facilitator Superfamily
EXW27_RS18705	COG0495	leucyl-tRNA aminoacylation
EXW27_RS18745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW27_RS18755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS18775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW27_RS18780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW27_RS18785	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW27_RS18790	COG0303	'Molybdopterin
EXW27_RS18795	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW27_RS18800	COG0314	molybdopterin synthase activity
EXW27_RS18825	COG1329	Transcriptional regulator
EXW27_RS18845	COG3832	glyoxalase III activity
EXW27_RS18855	COG2814	Major facilitator Superfamily
EXW27_RS18860	COG2081	HI0933 family
EXW27_RS18865	COG2244	polysaccharide biosynthetic process
EXW27_RS18870	COG1187	pseudouridine synthase activity
EXW27_RS18875	COG1349	DNA-binding transcription factor activity
EXW27_RS18880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW27_RS18890	COG1523	belongs to the glycosyl hydrolase 13 family
EXW27_RS18895	COG0510	thiamine kinase activity
EXW27_RS18905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW27_RS18910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS18920	COG1363	Peptidase, m42
EXW27_RS18925	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW27_RS18930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS18935	COG4848	Belongs to the UPF0354 family
EXW27_RS18940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW27_RS18955	COG1674	ftsk spoiiie
EXW27_RS18965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW27_RS18970	COG0789	Transcriptional regulator
EXW27_RS19000	COG2309	aminopeptidase activity
EXW27_RS19010	COG3118	belongs to the thioredoxin family
EXW27_RS19015	COG4851	CamS sex pheromone cAM373 precursor
EXW27_RS19030	COG1609	Transcriptional regulator
EXW27_RS19050	COG1970	mechanosensitive ion channel activity
EXW27_RS19060	COG0666	response to abiotic stimulus
EXW27_RS19065	COG5002	protein histidine kinase activity
EXW27_RS19070	COG0745	RESPONSE REGULATOR receiver
EXW27_RS19080	COG2267	carboxylic ester hydrolase activity
EXW27_RS19085	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW27_RS19090	COG0517	IMP dehydrogenase activity
EXW27_RS19095	COG0454	-acetyltransferase
EXW27_RS19100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW27_RS19105	COG0456	acetyltransferase
EXW27_RS19110	COG0110	maltose O-acetyltransferase activity
EXW27_RS19120	COG1595	DNA-templated transcription, initiation
EXW27_RS19145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW27_RS19150	COG0626	cystathionine gamma-synthase activity
EXW27_RS19155	COG1956	GAF domain-containing protein
EXW27_RS19160	COG1309	transcriptional regulator
EXW27_RS19175	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW27_RS19180	COG1104	cysteine desulfurase activity
EXW27_RS19195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW27_RS19205	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW27_RS19220	COG3874	Sporulation protein YtfJ
EXW27_RS19225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW27_RS19230	COG0827	DNA restriction-modification system
EXW27_RS19235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW27_RS19255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS19270	COG0137	argininosuccinate synthase activity
EXW27_RS19275	COG0165	Argininosuccinate lyase
EXW27_RS19295	COG0589	response to stress
EXW27_RS19300	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS19315	COG1476	TRANSCRIPTIONal
EXW27_RS19325	COG0662	Cupin 2, conserved barrel domain protein
EXW27_RS19360	COG0006	proline dipeptidase activity
EXW27_RS19365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW27_RS19375	COG4109	DRTGG domain
EXW27_RS19390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW27_RS19405	COG0587	DNA-directed DNA polymerase activity
EXW27_RS19410	COG0281	malic enzyme
EXW27_RS19415	COG1725	Transcriptional regulator
EXW27_RS19420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW27_RS19430	COG0205	6-phosphofructokinase activity
EXW27_RS19440	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW27_RS19445	COG0628	permease
EXW27_RS19455	COG0372	Belongs to the citrate synthase family
EXW27_RS19460	COG0538	isocitrate dehydrogenase activity
EXW27_RS19465	COG0039	L-malate dehydrogenase activity
EXW27_RS19480	COG0745	RESPONSE REGULATOR receiver
EXW27_RS19485	COG5002	protein histidine kinase activity
EXW27_RS19490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW27_RS19490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW27_RS19500	COG1971	Probably functions as a manganese efflux pump
EXW27_RS19505	COG0237	dephospho-CoA kinase activity
EXW27_RS19510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW27_RS19515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW27_RS19520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW27_RS19525	COG3611	Membrane attachment protein
EXW27_RS19530	COG1484	DNA-dependent DNA replication
EXW27_RS19540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW27_RS19555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW27_RS19565	COG1363	Peptidase, m42
EXW27_RS19575	COG1566	PFAM secretion protein HlyD family protein
EXW27_RS19580	COG2814	Major facilitator Superfamily
EXW27_RS19610	COG1418	mRNA catabolic process
EXW27_RS19620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW27_RS19625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW27_RS19650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW27_RS19655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW27_RS19660	COG1286	toxin biosynthetic process
EXW27_RS19665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW27_RS19665	COG1796	DNA polymerase
EXW27_RS19670	COG1193	negative regulation of DNA recombination
EXW27_RS19675	COG1187	pseudouridine synthase activity
EXW27_RS19680	COG1114	Component of the transport system for branched-chain amino acids
EXW27_RS19685	COG5386	Cell surface protein
EXW27_RS19695	COG5386	Cell surface protein
EXW27_RS19710	COG1120	ATPase activity
EXW27_RS19715	COG4509	Sortase family
EXW27_RS19720	COG2329	Antibiotic biosynthesis monooxygenase
EXW27_RS19730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW27_RS19735	COG4895	conserved protein (DUF2196)
EXW27_RS19745	COG0745	RESPONSE REGULATOR receiver
EXW27_RS19750	COG2205	protein histidine kinase activity
EXW27_RS19755	COG1131	(ABC) transporter
EXW27_RS19785	COG2318	DinB family
EXW27_RS19810	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS19815	COG1309	transcriptional regulator
EXW27_RS19820	COG1024	Enoyl-CoA hydratase
EXW27_RS19825	COG2086	electron transfer activity
EXW27_RS19830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW27_RS19835	COG3118	belongs to the thioredoxin family
EXW27_RS19840	COG0322	excinuclease ABC activity
EXW27_RS19845	COG1719	4-vinyl reductase, 4VR
EXW27_RS19850	COG2009	succinate dehydrogenase
EXW27_RS19855	COG1053	succinate dehydrogenase
EXW27_RS19860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW27_RS19865	COG0824	Thioesterase
EXW27_RS19870	COG1876	peptidase activity
EXW27_RS19875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW27_RS19880	COG1360	Flagellar Motor Protein
EXW27_RS19885	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW27_RS19890	COG4152	abc transporter atp-binding protein
EXW27_RS19895	COG1668	transmembrane transport
EXW27_RS19900	COG1959	2 iron, 2 sulfur cluster binding
EXW27_RS19910	COG0697	spore germination
EXW27_RS19915	COG1396	sequence-specific DNA binding
EXW27_RS19920	COG1983	PspC domain protein
EXW27_RS19925	COG0402	S-adenosylhomocysteine deaminase activity
EXW27_RS19930	COG2233	PERMEase
EXW27_RS19935	COG2197	response regulator
EXW27_RS19940	COG0477	Major facilitator Superfamily
EXW27_RS19950	COG5401	PFAM Sporulation and spore germination
EXW27_RS19955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW27_RS19965	COG0622	Phosphoesterase
EXW27_RS19995	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW27_RS20005	COG0470	DNA polymerase III
EXW27_RS20005	COG1067	ATP-dependent peptidase activity
EXW27_RS20015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW27_RS20020	COG1764	response to oxidative stress
EXW27_RS20025	COG1846	Transcriptional regulator
EXW27_RS20030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW27_RS20035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW27_RS20040	COG0181	hydroxymethylbilane synthase activity
EXW27_RS20045	COG1587	Uroporphyrinogen-III synthase
EXW27_RS20050	COG0113	porphobilinogen synthase activity
EXW27_RS20055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW27_RS20060	COG1388	LysM domain
EXW27_RS20075	COG0285	dihydrofolate synthase activity
EXW27_RS20085	COG0424	maF-like protein
EXW27_RS20090	COG2003	Belongs to the UPF0758 family
EXW27_RS20095	COG1077	Cell shape determining protein MreB Mrl
EXW27_RS20110	COG0850	regulation of cytokinetic process
EXW27_RS20115	COG2894	cell division
EXW27_RS20120	COG0739	heme binding
EXW27_RS20125	COG1994	Peptidase M50
EXW27_RS20130	COG1530	ribonuclease E activity
EXW27_RS20140	COG2868	ribosomal protein
EXW27_RS20150	COG3290	protein histidine kinase activity
EXW27_RS20155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW27_RS20160	COG0745	RESPONSE REGULATOR receiver
EXW27_RS20165	COG5002	protein histidine kinase activity
EXW27_RS20170	COG1136	(ABC) transporter
EXW27_RS20175	COG0577	efflux transmembrane transporter activity
EXW27_RS20180	COG0577	efflux transmembrane transporter activity
EXW27_RS20185	COG0077	Prephenate dehydratase
EXW27_RS20190	COG2258	MOSC domain
EXW27_RS20195	COG1827	regulation of RNA biosynthetic process
EXW27_RS20200	COG1104	cysteine desulfurase activity
EXW27_RS20205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW27_RS20210	COG0157	Belongs to the NadC ModD family
EXW27_RS20215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW27_RS20240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW27_RS20245	COG0632	four-way junction helicase activity
EXW27_RS20250	COG2255	four-way junction helicase activity
EXW27_RS20260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW27_RS20265	COG0343	queuine tRNA-ribosyltransferase activity
EXW27_RS20270	COG1862	Preprotein translocase
EXW27_RS20280	COG2323	membrane
EXW27_RS20285	COG2244	polysaccharide biosynthetic process
EXW27_RS20295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW27_RS20295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW27_RS20300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW27_RS20305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW27_RS20305	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW27_RS20310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW27_RS20315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW27_RS20320	COG1490	D-aminoacyl-tRNA deacylase activity
EXW27_RS20335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW27_RS20340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW27_RS20350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW27_RS20355	COG1959	2 iron, 2 sulfur cluster binding
EXW27_RS20360	COG1104	cysteine desulfurase activity
EXW27_RS20365	COG0482	sulfurtransferase activity
EXW27_RS20375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW27_RS20395	COG0628	permease
EXW27_RS20405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW27_RS20410	COG4472	Bacterial protein of unknown function (DUF965)
EXW27_RS20415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW27_RS20425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW27_RS20430	COG4122	O-methyltransferase activity
EXW27_RS20435	COG0826	peptidase U32
EXW27_RS20440	COG0826	peptidase U32
EXW27_RS20445	COG0572	uridine kinase
EXW27_RS20450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW27_RS20455	COG0768	penicillin binding
EXW27_RS20470	COG2226	methyltransferase
EXW27_RS20475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW27_RS20480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW27_RS20485	COG0626	cystathionine gamma-synthase activity
EXW27_RS20490	COG1454	alcohol dehydrogenase
EXW27_RS20490	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS20500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS20540	COG2259	Doxx family
EXW27_RS20545	COG2514	catechol 2,3-dioxygenase activity
EXW27_RS20550	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW27_RS20555	COG3186	Phenylalanine-4-hydroxylase
EXW27_RS20560	COG1404	Belongs to the peptidase S8 family
EXW27_RS20595	COG2267	carboxylic ester hydrolase activity
EXW27_RS20605	COG1785	Belongs to the alkaline phosphatase family
EXW27_RS20615	COG2357	RelA SpoT domain protein
EXW27_RS20620	COG1595	DNA-templated transcription, initiation
EXW27_RS20630	COG0688	phosphatidylethanolamine metabolic process
EXW27_RS20640	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW27_RS20645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW27_RS20650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW27_RS20655	COG1534	Rna-binding protein
EXW27_RS20660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW27_RS20665	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW27_RS20670	COG0799	negative regulation of ribosome biogenesis
EXW27_RS20675	COG2226	methyltransferase
EXW27_RS20680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW27_RS20685	COG1555	photosystem II stabilization
EXW27_RS20685	COG1596	polysaccharide export
EXW27_RS20690	COG2131	deaminase
EXW27_RS20695	COG0658	competence protein
EXW27_RS20695	COG2333	competence protein COMEC
EXW27_RS20705	COG1466	dna polymerase III delta subunit
EXW27_RS20710	COG0268	Binds directly to 16S ribosomal RNA
EXW27_RS20715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW27_RS20725	COG0481	GTPase activity
EXW27_RS20730	COG1733	regulation of RNA biosynthetic process
EXW27_RS20735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW27_RS20740	COG1420	regulation of RNA biosynthetic process
EXW27_RS20750	COG0443	Heat shock 70 kDa protein
EXW27_RS20755	COG0484	heat shock protein binding
EXW27_RS20765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW27_RS20770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW27_RS20775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW27_RS20780	COG1610	YqeY-like protein
EXW27_RS20795	COG1702	phosphate starvation-inducible protein PhoH
EXW27_RS20800	COG1480	7TM receptor with intracellular HD hydrolase
EXW27_RS20805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW27_RS20810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW27_RS20815	COG0295	cytidine deaminase activity
EXW27_RS20820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW27_RS20830	COG1381	Involved in DNA repair and RecF pathway recombination
EXW27_RS20835	COG0517	IMP dehydrogenase activity
EXW27_RS20840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW27_RS20845	COG0358	DNA primase activity
EXW27_RS20850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW27_RS20855	COG2010	Cytochrome c
EXW27_RS20860	COG2384	SAM-dependent methyltransferase
EXW27_RS20865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW27_RS20870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW27_RS20885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW27_RS20895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS20900	COG1121	(ABC) transporter
EXW27_RS20905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW27_RS20910	COG0735	belongs to the Fur family
EXW27_RS20915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW27_RS20940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW27_RS20945	COG0477	Major facilitator Superfamily
EXW27_RS20950	COG0768	penicillin binding
EXW27_RS20955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW27_RS20960	COG0573	inorganic phosphate transmembrane transporter activity
EXW27_RS20965	COG0581	inorganic phosphate transmembrane transporter activity
EXW27_RS20975	COG0704	Plays a role in the regulation of phosphate uptake
EXW27_RS20980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW27_RS20985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW27_RS20990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW27_RS20995	COG4483	Protein conserved in bacteria
EXW27_RS21000	COG1940	carbohydrate kinase activity
EXW27_RS21010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS21030	COG0626	cystathionine gamma-synthase activity
EXW27_RS21035	COG0626	cystathionine gamma-synthase activity
EXW27_RS21040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW27_RS21040	COG0646	methionine synthase
EXW27_RS21045	COG0646	methionine synthase
EXW27_RS21045	COG1410	methionine synthase
EXW27_RS21100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW27_RS21105	COG1459	type II secretion system
EXW27_RS21115	COG4970	Tfp pilus assembly protein FimT
EXW27_RS21140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW27_RS21165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW27_RS21170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW27_RS21175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW27_RS21180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW27_RS21195	COG1725	Transcriptional regulator
EXW27_RS21230	COG2076	Multidrug Resistance protein
EXW27_RS21235	COG2076	Multidrug Resistance protein
EXW27_RS21245	COG1609	Transcriptional regulator
EXW27_RS21255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW27_RS21290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW27_RS21300	COG3872	metal-dependent enzyme
EXW27_RS21310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW27_RS21315	COG0006	proline dipeptidase activity
EXW27_RS21320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW27_RS21340	COG3854	ATPases associated with a variety of cellular activities
EXW27_RS21385	COG0511	ligase activity, forming carbon-carbon bonds
EXW27_RS21390	COG0439	Biotin carboxylase
EXW27_RS21395	COG1302	Protein conserved in bacteria
EXW27_RS21400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW27_RS21405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW27_RS21410	COG1570	exodeoxyribonuclease VII activity
EXW27_RS21415	COG1722	exodeoxyribonuclease VII activity
EXW27_RS21420	COG0142	geranyltranstransferase activity
EXW27_RS21425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW27_RS21430	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW27_RS21435	COG1438	arginine binding
EXW27_RS21440	COG0497	DNA recombination
EXW27_RS21445	COG0750	zinc metalloprotease
EXW27_RS21450	COG0745	RESPONSE REGULATOR receiver
EXW27_RS21460	COG3093	addiction module antidote protein HigA
EXW27_RS21465	COG0584	glycerophosphoryl diester phosphodiesterase
EXW27_RS21475	COG3290	protein histidine kinase activity
EXW27_RS21475	COG3829	transcription factor binding
EXW27_RS21480	COG0280	phosphate acetyltransferase
EXW27_RS21490	COG3426	butyrate kinase activity
EXW27_RS21495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW27_RS21500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW27_RS21505	COG0022	dehydrogenase e1 component
EXW27_RS21510	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW27_RS21515	COG0772	Belongs to the SEDS family
EXW27_RS21520	COG2323	membrane
EXW27_RS21525	COG2816	NAD+ diphosphatase activity
EXW27_RS21535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS21540	COG0765	amino acid transport
EXW27_RS21545	COG1126	abc transporter atp-binding protein
EXW27_RS21550	COG4129	membrane
EXW27_RS21555	COG1376	ErfK ybiS ycfS ynhG family protein
EXW27_RS21570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW27_RS21575	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW27_RS21590	COG1285	pathogenesis
EXW27_RS21605	COG1234	tRNA 3'-trailer cleavage
EXW27_RS21615	COG1760	l-serine dehydratase
EXW27_RS21620	COG1760	l-serine dehydratase
EXW27_RS21625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW27_RS21630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS21635	COG0300	oxidoreductase activity
EXW27_RS21645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW27_RS21680	COG1522	sequence-specific DNA binding
EXW27_RS21690	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS21695	COG1757	Na H antiporter
EXW27_RS21705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW27_RS21715	COG0156	8-amino-7-oxononanoate synthase activity
EXW27_RS21720	COG1073	alpha beta
EXW27_RS21720	COG2226	methyltransferase
EXW27_RS21725	COG4106	trans-aconitate 2-methyltransferase activity
EXW27_RS21730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW27_RS21745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW27_RS21745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW27_RS21750	COG0307	riboflavin synthase, alpha
EXW27_RS21755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW27_RS21755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW27_RS21770	COG1073	alpha beta
EXW27_RS21775	COG0456	acetyltransferase
EXW27_RS21780	COG1609	Transcriptional regulator
EXW27_RS21785	COG2056	Na+-H+ antiporter family
EXW27_RS21790	COG0596	Alpha beta hydrolase
EXW27_RS21800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW27_RS21805	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS21805	COG1525	nuclease
EXW27_RS21805	COG4085	toxin activity
EXW27_RS21815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW27_RS21815	COG0456	acetyltransferase
EXW27_RS21820	COG0656	L-ascorbic acid biosynthetic process
EXW27_RS21825	COG0667	Aldo Keto reductase
EXW27_RS21845	COG1300	Membrane
EXW27_RS21850	COG0735	belongs to the Fur family
EXW27_RS21860	COG4974	Belongs to the 'phage' integrase family
EXW27_RS21870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW27_RS21885	COG0598	Magnesium transport protein CorA
EXW27_RS21900	COG1846	Transcriptional regulator
EXW27_RS21920	COG1131	(ABC) transporter
EXW27_RS21925	COG1725	Transcriptional regulator
EXW27_RS21930	COG1686	Belongs to the peptidase S11 family
EXW27_RS21970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW27_RS21985	COG0697	spore germination
EXW27_RS21990	COG0561	phosphatase activity
EXW27_RS21995	COG4086	secreted protein
EXW27_RS22000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW27_RS22010	COG1547	Domain of unknown function (DUF309)
EXW27_RS22020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW27_RS22025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW27_RS22035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW27_RS22040	COG0363	glucosamine-6-phosphate deaminase activity
EXW27_RS22045	COG2188	Transcriptional regulator
EXW27_RS22055	COG3711	transcriptional antiterminator
EXW27_RS22060	COG2190	(PTS) system
EXW27_RS22060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS22060	COG1263	PTS System
EXW27_RS22085	COG0778	Nitroreductase
EXW27_RS22090	COG2199	diguanylate cyclase activity
EXW27_RS22100	COG2084	Dehydrogenase
EXW27_RS22115	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW27_RS22120	COG0235	Class ii aldolase
EXW27_RS22125	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW27_RS22130	COG1850	ribulose-bisphosphate carboxylase activity
EXW27_RS22135	COG0436	Aminotransferase
EXW27_RS22140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW27_RS22145	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW27_RS22150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW27_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS22165	COG1695	Transcriptional regulator
EXW27_RS22200	COG0183	Belongs to the thiolase family
EXW27_RS22240	COG3842	ATPase activity
EXW27_RS22245	COG0366	Alpha amylase catalytic
EXW27_RS22255	COG2182	Extracellular solute-binding protein
EXW27_RS22260	COG1175	transmembrane transport
EXW27_RS22265	COG3833	ABC-type maltose transport systems, permease component
EXW27_RS22270	COG1609	Transcriptional regulator
EXW27_RS22275	COG0436	Aminotransferase
EXW27_RS22285	COG2205	protein histidine kinase activity
EXW27_RS22295	COG3209	COG3209 Rhs family protein
EXW27_RS22305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW27_RS22315	COG2814	Major facilitator Superfamily
EXW27_RS22360	COG1408	metallophosphoesterase
EXW27_RS22365	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS22370	COG2200	EAL domain
EXW27_RS22385	COG4703	Protein of unknown function (DUF1797)
EXW27_RS22395	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW27_RS22405	COG0517	IMP dehydrogenase activity
EXW27_RS22410	COG0583	DNA-binding transcription factor activity
EXW27_RS22415	COG2171	N-acyltransferase activity
EXW27_RS22420	COG1473	amidohydrolase
EXW27_RS22430	COG0569	domain protein
EXW27_RS22435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW27_RS22440	COG5503	Protein of unknown function (DUF1447)
EXW27_RS22445	COG0561	phosphatase activity
EXW27_RS22460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW27_RS22465	COG0022	dehydrogenase e1 component
EXW27_RS22470	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW27_RS22515	COG1982	Orn Lys Arg decarboxylase major
EXW27_RS22520	COG4476	Belongs to the UPF0223 family
EXW27_RS22525	COG4493	Belongs to the UPF0637 family
EXW27_RS22535	COG0483	inositol monophosphate 1-phosphatase activity
EXW27_RS22545	COG1217	gtp-binding protein TYPA
EXW27_RS22560	COG4896	Protein conserved in bacteria
EXW27_RS22570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW27_RS22575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW27_RS22580	COG4838	Belongs to the UPF0358 family
EXW27_RS22585	COG0772	Belongs to the SEDS family
EXW27_RS22590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW27_RS22595	COG1612	heme a metabolic process
EXW27_RS22600	COG0109	protoheme IX farnesyltransferase activity
EXW27_RS22625	COG3336	cytochrome c oxidase
EXW27_RS22635	COG2340	Cysteine-rich secretory protein family
EXW27_RS22650	COG0406	alpha-ribazole phosphatase activity
EXW27_RS22655	COG3679	Belongs to the UPF0342 family
EXW27_RS22660	COG4471	UPF0298 protein
EXW27_RS22670	COG0742	ribosomal rna small subunit methyltransferase
EXW27_RS22680	COG3314	Sporulation integral membrane protein YlbJ
EXW27_RS22685	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW27_RS22690	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW27_RS22695	COG1323	Belongs to the UPF0348 family
EXW27_RS22700	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW27_RS22705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW27_RS22715	COG0454	-acetyltransferase
EXW27_RS22720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW27_RS22725	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW27_RS22730	COG0275	rRNA processing
EXW27_RS22740	COG0768	penicillin binding
EXW27_RS22745	COG0768	penicillin binding
EXW27_RS22750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW27_RS22755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW27_RS22760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW27_RS22765	COG0772	Belongs to the SEDS family
EXW27_RS22780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW27_RS22785	COG0849	cell division
EXW27_RS22790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW27_RS22800	COG1191	sigma factor activity
EXW27_RS22805	COG1191	sigma factor activity
EXW27_RS22810	COG1873	PFAM PRC-barrel domain
EXW27_RS22820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW27_RS22825	COG1799	cell septum assembly
EXW27_RS22830	COG0762	integral membrane protein
EXW27_RS22835	COG2302	S4 RNA-binding domain
EXW27_RS22840	COG3599	regulation of cell shape
EXW27_RS22845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW27_RS22855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW27_RS22860	COG0564	pseudouridine synthase activity
EXW27_RS22865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW27_RS22875	COG0540	Belongs to the ATCase OTCase family
EXW27_RS22880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW27_RS22890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW27_RS22895	COG0543	2 iron, 2 sulfur cluster binding
EXW27_RS22900	COG0167	dihydroorotate dehydrogenase activity
EXW27_RS22925	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW27_RS22945	COG0006	proline dipeptidase activity
EXW27_RS22955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW27_RS22960	COG1561	YicC-like family, N-terminal region
EXW27_RS22975	COG1758	RNA polymerase activity
EXW27_RS22980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW27_RS22985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW27_RS22990	COG0242	peptide deformylase activity
EXW27_RS22995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW27_RS23000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW27_RS23000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW27_RS23005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW27_RS23010	COG0631	protein serine/threonine phosphatase activity
EXW27_RS23015	COG2815	serine threonine protein kinase
EXW27_RS23015	COG0515	serine threonine protein kinase
EXW27_RS23025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW27_RS23030	COG1564	THIamine pyrophosphokinase
EXW27_RS23045	COG1302	Protein conserved in bacteria
EXW27_RS23050	COG1461	Dihydroxyacetone kinase
EXW27_RS23055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW27_RS23060	COG1349	DNA-binding transcription factor activity
EXW27_RS23060	COG2050	protein possibly involved in aromatic compounds catabolism
EXW27_RS23065	COG0416	fatty acid biosynthetic process
EXW27_RS23070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW27_RS23075	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS23080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW27_RS23085	COG0571	ribonuclease III activity
EXW27_RS23090	COG1196	nuclear chromosome segregation
EXW27_RS23095	COG0552	protein localization to endoplasmic reticulum
EXW27_RS23105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW27_RS23115	COG1837	Belongs to the UPF0109 family
EXW27_RS23120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW27_RS23125	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW27_RS23130	COG0335	large ribosomal subunit rRNA binding
EXW27_RS23145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW27_RS23150	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW27_RS23155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW27_RS23160	COG0758	DNA mediated transformation
EXW27_RS23165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW27_RS23170	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW27_RS23175	COG4974	Belongs to the 'phage' integrase family
EXW27_RS23180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW27_RS23185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW27_RS23190	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW27_RS23200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW27_RS23205	COG0528	UMP kinase activity
EXW27_RS23210	COG0233	cytoplasmic translational termination
EXW27_RS23220	COG4589	Belongs to the CDS family
EXW27_RS23230	COG0750	zinc metalloprotease
EXW27_RS23235	COG0442	prolyl-tRNA aminoacylation
EXW27_RS23245	COG0779	Required for maturation of 30S ribosomal subunits
EXW27_RS23250	COG0195	Participates in both transcription termination and antitermination
EXW27_RS23255	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW27_RS23260	COG1358	cellular component organization or biogenesis
EXW27_RS23265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW27_RS23270	COG1550	Protein conserved in bacteria
EXW27_RS23275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW27_RS23285	COG0196	riboflavin kinase activity
EXW27_RS23295	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW27_RS23300	COG0726	polysaccharide deacetylase
EXW27_RS23305	COG0612	Peptidase, M16
EXW27_RS23310	COG1873	PFAM PRC-barrel domain
EXW27_RS23315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW27_RS23345	COG1396	sequence-specific DNA binding
EXW27_RS23380	COG0305	Participates in initiation and elongation during chromosome replication
EXW27_RS23450	COG0582	viral genome integration into host DNA
EXW27_RS23600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW27_RS23605	COG0527	aspartate kinase activity
EXW27_RS23615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW27_RS23620	COG0740	serine-type endopeptidase activity
EXW27_RS23630	COG1674	ftsk spoiiie
EXW27_RS23640	COG2188	Transcriptional regulator
EXW27_RS23645	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW27_RS23650	COG3845	ABC transporter
EXW27_RS23655	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW27_RS23660	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW27_RS23665	COG0612	Peptidase, M16
EXW27_RS23670	COG0612	Peptidase, M16
EXW27_RS23675	COG0300	oxidoreductase activity
EXW27_RS23690	COG1426	Protein conserved in bacteria
EXW27_RS23695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW27_RS23700	COG1058	Belongs to the CinA family
EXW27_RS23700	COG1546	Belongs to the CinA family
EXW27_RS23705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW27_RS23710	COG1418	mRNA catabolic process
EXW27_RS23715	COG1692	metallophosphoesterase
EXW27_RS23720	COG2359	stage V sporulation protein S
EXW27_RS23730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW27_RS23730	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW27_RS23735	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW27_RS23740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW27_RS23745	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW27_RS23755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW27_RS23760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW27_RS23765	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW27_RS23775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW27_RS23785	COG3773	Cell wall hydrolase
EXW27_RS23795	COG2723	6-phospho-beta-galactosidase activity
EXW27_RS23800	COG2188	Transcriptional regulator
EXW27_RS23810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW27_RS23815	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW27_RS23815	COG0596	Alpha beta hydrolase
EXW27_RS23820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS23830	COG1346	cytolysis
EXW27_RS23870	COG5001	Diguanylate cyclase
EXW27_RS23870	COG3300	MHYT domain
EXW27_RS23875	COG0346	lactoylglutathione lyase activity
EXW27_RS23885	COG2364	Membrane
EXW27_RS23890	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW27_RS23895	COG2706	6-phosphogluconolactonase activity
EXW27_RS23900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW27_RS23905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW27_RS23910	COG2169	Transcriptional regulator
EXW27_RS23915	COG0708	Exodeoxyribonuclease III
EXW27_RS23920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS23925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS23930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS23935	COG1120	ATPase activity
EXW27_RS23940	COG2819	hydrolase of the alpha beta superfamily
EXW27_RS23945	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW27_RS23950	COG4566	intracellular signal transduction
EXW27_RS23980	COG1937	Protein conserved in bacteria
EXW27_RS23985	COG2608	mercury ion transmembrane transporter activity
EXW27_RS23990	COG2217	Heavy metal translocating P-type atpase
EXW27_RS24005	COG2116	formate transmembrane transporter activity
EXW27_RS24010	COG1408	metallophosphoesterase
EXW27_RS24015	COG1473	amidohydrolase
EXW27_RS24025	COG1113	amino acid transport
EXW27_RS24035	COG2322	membrane
EXW27_RS24040	COG1979	alcohol dehydrogenase
EXW27_RS24045	COG1349	DNA-binding transcription factor activity
EXW27_RS24050	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW27_RS24055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW27_RS24055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW27_RS24055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW27_RS24060	COG3584	3D domain protein
EXW27_RS24060	COG1388	LysM domain
EXW27_RS24070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW27_RS24105	COG0464	growth
EXW27_RS24115	COG2860	membrane
EXW27_RS24120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW27_RS24125	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW27_RS24130	COG0789	Transcriptional regulator
EXW27_RS24135	COG0174	glutamine synthetase
EXW27_RS24140	COG3944	biosynthesis protein
EXW27_RS24145	COG0489	protein tyrosine kinase activity
EXW27_RS24150	COG1086	Polysaccharide biosynthesis protein
EXW27_RS24155	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS24160	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS24165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW27_RS24165	COG0463	Glycosyl transferase, family 2
EXW27_RS24175	COG0438	transferase activity, transferring glycosyl groups
EXW27_RS24200	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW27_RS24200	COG3420	alginic acid biosynthetic process
EXW27_RS24205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW27_RS24210	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW27_RS24220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW27_RS24255	COG1132	(ABC) transporter
EXW27_RS24260	COG1695	Transcriptional regulator
EXW27_RS24275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW27_RS24280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW27_RS24290	COG0737	Belongs to the 5'-nucleotidase family
EXW27_RS24295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS24305	COG3639	organic phosphonate transmembrane transporter activity
EXW27_RS24325	COG3763	UPF0154 protein
EXW27_RS24330	COG1132	(ABC) transporter
EXW27_RS24335	COG1132	(ABC) transporter
EXW27_RS24355	COG3409	Peptidoglycan-binding domain 1 protein
EXW27_RS24355	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW27_RS24365	COG0730	response to heat
EXW27_RS24380	COG1346	cytolysis
EXW27_RS24390	COG0583	DNA-binding transcription factor activity
EXW27_RS24400	COG1131	(ABC) transporter
EXW27_RS24405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW27_RS24410	COG1473	amidohydrolase
EXW27_RS24420	COG0785	Cytochrome C biogenesis protein
EXW27_RS24425	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW27_RS24450	COG2226	methyltransferase
EXW27_RS24460	COG2986	histidine ammonia-lyase
EXW27_RS24465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW27_RS24475	COG0010	Belongs to the arginase family
EXW27_RS24480	COG1329	Transcriptional regulator
EXW27_RS24490	COG1902	pentaerythritol trinitrate reductase activity
EXW27_RS24495	COG0069	glutamate synthase activity
EXW27_RS24500	COG0346	lactoylglutathione lyase activity
EXW27_RS24505	COG0400	carboxylic ester hydrolase activity
EXW27_RS24515	COG5002	protein histidine kinase activity
EXW27_RS24525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS24565	COG0830	nickel cation binding
EXW27_RS24585	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EXW27_RS24605	COG1396	sequence-specific DNA binding
EXW27_RS24610	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS24615	COG1268	BioY protein
EXW27_RS24620	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS24625	COG0183	Belongs to the thiolase family
EXW27_RS24640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW27_RS24650	COG2211	Major facilitator Superfamily
EXW27_RS24680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW27_RS24685	COG1132	(ABC) transporter
EXW27_RS24700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW27_RS24725	COG0824	Thioesterase
EXW27_RS24730	COG4841	protein insertion into membrane
EXW27_RS24740	COG1328	CTP reductase activity
EXW27_RS24750	COG0745	RESPONSE REGULATOR receiver
EXW27_RS24755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW27_RS24760	COG1832	CoA-binding protein
EXW27_RS24765	COG0187	DNA topoisomerase II activity
EXW27_RS24770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW27_RS24775	COG0673	inositol 2-dehydrogenase activity
EXW27_RS24795	COG1131	(ABC) transporter
EXW27_RS24815	COG1316	TRANSCRIPTIONal
EXW27_RS24820	COG4166	transmembrane transport
EXW27_RS24825	COG4166	transmembrane transport
EXW27_RS24830	COG4166	transmembrane transport
EXW27_RS24835	COG2226	methyltransferase
EXW27_RS24870	COG0531	amino acid
EXW27_RS24875	COG3326	Membrane
EXW27_RS24880	COG2962	Rard protein
EXW27_RS24885	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW27_RS24890	COG1657	PFAM Prenyltransferase squalene oxidase
EXW27_RS24900	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS24905	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS24915	COG4145	pantothenate transmembrane transporter activity
EXW27_RS24930	COG0165	Argininosuccinate lyase
EXW27_RS24940	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS24960	COG0494	nUDIX hydrolase
EXW27_RS24970	COG0716	FMN binding
EXW27_RS24980	COG1278	Cold shock
EXW27_RS25005	COG2720	vancomycin resistance protein
EXW27_RS25010	COG0765	amino acid transport
EXW27_RS25015	COG1126	abc transporter atp-binding protein
EXW27_RS25020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW27_RS25025	COG2514	catechol 2,3-dioxygenase activity
EXW27_RS25035	COG1285	pathogenesis
EXW27_RS25055	COG0277	FAD linked oxidase domain protein
EXW27_RS25065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW27_RS25070	COG2808	Putative FMN-binding domain
EXW27_RS25075	COG0457	Tetratricopeptide repeat
EXW27_RS25085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW27_RS25090	COG0604	alcohol dehydrogenase
EXW27_RS25095	COG0640	Transcriptional regulator
EXW27_RS25100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW27_RS25140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW27_RS25155	COG3781	membrane
EXW27_RS25175	COG2957	Belongs to the agmatine deiminase family
EXW27_RS25180	COG1164	Oligoendopeptidase f
EXW27_RS25185	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW27_RS25195	COG1193	negative regulation of DNA recombination
EXW27_RS25220	COG0583	DNA-binding transcription factor activity
EXW27_RS25240	COG3739	integral membrane protein
EXW27_RS25245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS25250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW27_RS25255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW27_RS25275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW27_RS25280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW27_RS25295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW27_RS25300	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS25305	COG0534	Mate efflux family protein
EXW27_RS25315	COG1012	belongs to the aldehyde dehydrogenase family
EXW27_RS25320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW27_RS25330	COG2814	Major facilitator Superfamily
EXW27_RS25340	COG1113	amino acid transport
EXW27_RS25345	COG0604	alcohol dehydrogenase
EXW27_RS25350	COG1695	Transcriptional regulator
EXW27_RS25395	COG2072	flavoprotein involved in K transport
EXW27_RS25405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW27_RS25435	COG1151	hydroxylamine reductase activity
EXW27_RS25465	COG0814	amino acid
EXW27_RS25505	COG5002	protein histidine kinase activity
EXW27_RS25530	COG0741	lytic transglycosylase activity
EXW27_RS25575	COG1876	peptidase activity
EXW27_RS25595	COG1191	sigma factor activity
EXW27_RS25610	COG1733	regulation of RNA biosynthetic process
EXW27_RS25615	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW27_RS25620	COG0318	PFAM AMP-dependent synthetase and ligase
EXW27_RS25630	COG0384	phenazine biosynthesis protein PhzF
EXW27_RS25645	COG0494	nUDIX hydrolase
EXW27_RS25660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW27_RS25670	COG1393	Belongs to the ArsC family
EXW27_RS25690	COG0814	amino acid
EXW27_RS25705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW27_RS25710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW27_RS25720	COG1070	Carbohydrate kinase
EXW27_RS25725	COG2706	6-phosphogluconolactonase activity
EXW27_RS25730	COG3813	Protein conserved in bacteria
EXW27_RS25735	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW27_RS25740	COG0697	spore germination
EXW27_RS25765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW27_RS25775	COG0789	Transcriptional regulator
EXW27_RS25780	COG1253	flavin adenine dinucleotide binding
EXW27_RS25790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW27_RS25825	COG2261	transglycosylase associated protein
EXW27_RS25830	COG0628	permease
EXW27_RS25845	COG0110	maltose O-acetyltransferase activity
EXW27_RS25850	COG0738	Major facilitator superfamily
EXW27_RS25855	COG1940	carbohydrate kinase activity
EXW27_RS25860	COG0346	lactoylglutathione lyase activity
EXW27_RS25885	COG2365	Tyrosine phosphatase family
EXW27_RS25890	COG1011	Hydrolase
EXW27_RS25905	COG1595	DNA-templated transcription, initiation
EXW27_RS25935	COG1131	(ABC) transporter
EXW27_RS25945	COG1028	Short-chain dehydrogenase reductase Sdr
EXW27_RS25960	COG1733	regulation of RNA biosynthetic process
EXW27_RS25965	COG0778	Nitroreductase
EXW27_RS25970	COG1785	Belongs to the alkaline phosphatase family
EXW27_RS25990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW27_RS26010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW27_RS26015	COG2356	endonuclease I
EXW27_RS26020	COG1288	antiporter activity
EXW27_RS26025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW27_RS26075	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW27_RS26085	COG2031	fatty acid transporter
EXW27_RS26100	COG4187	Peptidase family M20/M25/M40
EXW27_RS26220	COG1131	(ABC) transporter
EXW27_RS26235	COG1136	(ABC) transporter
EXW27_RS26250	COG5002	protein histidine kinase activity
EXW27_RS26300	COG1329	Transcriptional regulator
EXW27_RS26325	COG0640	Transcriptional regulator
EXW27_RS26345	COG2814	Major facilitator Superfamily
EXW27_RS26350	COG1846	Transcriptional regulator
EXW27_RS26365	COG0477	Major facilitator Superfamily
EXW27_RS26480	COG2814	Major facilitator Superfamily
EXW27_RS26485	COG1309	transcriptional regulator
EXW27_RS26515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW27_RS26535	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW27_RS26550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW27_RS26560	COG5002	protein histidine kinase activity
EXW27_RS26560	COG3850	Histidine kinase
EXW27_RS26580	COG0577	efflux transmembrane transporter activity
EXW27_RS26585	COG1136	(ABC) transporter
EXW27_RS26600	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW27_RS26610	COG1522	sequence-specific DNA binding
EXW27_RS26635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW27_RS26650	COG2814	Major facilitator Superfamily
EXW27_RS26690	COG4977	sequence-specific DNA binding
EXW27_RS26715	COG5002	protein histidine kinase activity
EXW27_RS26725	COG0745	RESPONSE REGULATOR receiver
EXW27_RS26730	COG5002	protein histidine kinase activity
EXW27_RS26740	COG1760	l-serine dehydratase
EXW27_RS26745	COG1760	l-serine dehydratase
EXW27_RS26750	COG0814	amino acid
EXW27_RS26760	COG1073	alpha beta
EXW27_RS26790	COG5002	protein histidine kinase activity
EXW27_RS26790	COG3850	Histidine kinase
EXW27_RS26795	COG0745	RESPONSE REGULATOR receiver
EXW27_RS26825	COG0346	lactoylglutathione lyase activity
EXW27_RS26845	COG1522	sequence-specific DNA binding
EXW27_RS26855	COG0640	Transcriptional regulator
EXW27_RS26860	COG0346	lactoylglutathione lyase activity
EXW27_RS26865	COG0798	PFAM Bile acid sodium symporter
EXW27_RS26905	COG0745	RESPONSE REGULATOR receiver
EXW27_RS26910	COG5002	protein histidine kinase activity
EXW27_RS26945	COG3848	Pyruvate phosphate dikinase
EXW27_RS26945	COG0574	Belongs to the PEP-utilizing enzyme family
EXW27_RS26980	COG1136	(ABC) transporter
EXW27_RS26985	COG0577	efflux transmembrane transporter activity
EXW27_RS26990	COG0577	efflux transmembrane transporter activity
EXW27_RS26995	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW27_RS27015	COG3314	Sporulation integral membrane protein YlbJ
EXW27_RS27025	COG0640	Transcriptional regulator
EXW27_RS27050	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS27060	COG3142	Participates in the control of copper homeostasis
EXW27_RS27070	COG1414	Transcriptional regulator
EXW27_RS27075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW27_RS27080	COG1984	allophanate hydrolase subunit 2
EXW27_RS27085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW27_RS27100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW27_RS27105	COG3104	oligopeptide transport
EXW27_RS27120	COG0768	penicillin binding
EXW27_RS27150	COG4335	DNA alkylation repair
EXW27_RS27160	COG0833	amino acid
EXW27_RS27170	COG0730	response to heat
EXW27_RS27195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW27_RS27195	COG0456	acetyltransferase
EXW27_RS27205	COG0596	Alpha beta hydrolase
EXW27_RS27210	COG0745	RESPONSE REGULATOR receiver
EXW27_RS27215	COG0642	Histidine kinase
EXW27_RS27230	COG0697	spore germination
EXW27_RS27235	COG0814	amino acid
EXW27_RS27260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW27_RS27265	COG0697	spore germination
EXW27_RS27280	COG0456	acetyltransferase
EXW27_RS27285	COG2207	Transcriptional regulator
EXW27_RS27315	COG0582	viral genome integration into host DNA
EXW27_RS27330	COG1396	sequence-specific DNA binding
EXW27_RS27340	COG3645	SOS response
EXW27_RS27340	COG3646	Phage regulatory protein
EXW27_RS27365	COG1484	DNA-dependent DNA replication
EXW27_RS27375	COG2002	toxin-antitoxin pair type II binding
EXW27_RS27410	COG0270	DNA (cytosine-5-)-methyltransferase activity
EXW27_RS27440	COG0582	viral genome integration into host DNA
EXW27_RS27495	COG1192	Involved in chromosome partitioning
EXW27_RS27660	COG5484	DNA packaging
EXW27_RS27670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW27_RS27720	COG2002	toxin-antitoxin pair type II binding
EXW27_RS27840	COG1396	sequence-specific DNA binding
EXW27_RS27970	COG0592	DNA-directed DNA polymerase activity
EXW27_RS27975	COG4712	double-strand break repair protein
EXW27_RS28120	COG4962	Type ii secretion system protein e
EXW27_RS28285	COG2311	Membrane
EXW27_RS28300	COG0519	Catalyzes the synthesis of GMP from XMP
EXW27_RS28390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW27_RS28420	COG0582	viral genome integration into host DNA
EXW27_RS28435	COG2378	regulation of single-species biofilm formation
EXW27_RS28440	COG2318	DinB family
EXW27_RS28450	COG0789	Transcriptional regulator
EXW27_RS28470	COG0840	transmembrane signaling receptor activity
EXW27_RS28540	COG4166	transmembrane transport
EXW27_RS28560	COG4974	Belongs to the 'phage' integrase family
EXW27_RS28625	COG1960	acyl-CoA dehydrogenase activity
EXW27_RS28630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW27_RS28670	COG0189	ligase activity
EXW27_RS28690	COG4974	Belongs to the 'phage' integrase family
EXW27_RS28730	COG0457	Tetratricopeptide repeat
EXW27_RS28820	COG0686	Belongs to the AlaDH PNT family
EXW27_RS28825	COG2508	Transcriptional regulator
EXW27_RS28825	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW27_RS28835	COG2124	cytochrome p450
EXW27_RS28860	COG1476	TRANSCRIPTIONal
EXW27_RS28870	COG2755	lipolytic protein G-D-S-L family
EXW27_RS28870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW27_RS28975	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EXW27_RS28980	COG1518	maintenance of DNA repeat elements
EXW27_RS29090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW27_RS29095	COG0653	protein targeting
EXW27_RS29110	COG2222	sugar isomerase
EXW27_RS29120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW27_RS29125	COG3715	PTS system
EXW27_RS29130	COG3716	PTS system mannose fructose sorbose family IID component
EXW27_RS29150	COG3684	Belongs to the aldolase LacD family
EXW27_RS29155	COG2188	Transcriptional regulator
EXW27_RS29300	COG0367	asparagine synthase
EXW27_RS29355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW27_RS29355	COG2755	lipolytic protein G-D-S-L family
EXW27_RS29365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW27_RS29370	COG1288	antiporter activity
EXW27_RS29445	COG0463	Glycosyl transferase, family 2
EXW27_RS29450	COG0463	Glycosyl transferase, family 2
EXW27_RS29455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW27_RS29460	COG1086	Polysaccharide biosynthesis protein
EXW27_RS29465	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW27_RS29470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW27_RS29475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW27_RS29490	COG2089	acid synthase
EXW27_RS29495	COG4641	Protein conserved in bacteria
EXW27_RS29545	COG0745	RESPONSE REGULATOR receiver
EXW27_RS29550	COG2205	protein histidine kinase activity
EXW27_RS29560	COG1136	(ABC) transporter
EXW27_RS29565	COG0577	efflux transmembrane transporter activity
EXW27_RS29575	COG2002	toxin-antitoxin pair type II binding
EXW27_RS29585	COG1923	regulation of RNA biosynthetic process
EXW27_RS29615	COG2814	Major facilitator Superfamily
EXW27_RS29640	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW27_RS29650	COG2002	toxin-antitoxin pair type II binding
EXW27_RS29720	COG1696	Membrane protein involved in D-alanine export
EXW27_RS29730	COG2814	Major facilitator Superfamily
EXW27_RS29775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW27_RS29825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW27_RS29835	COG0583	DNA-binding transcription factor activity
EXW27_RS29840	COG0768	penicillin binding
EXW27_RS29850	COG4990	cell redox homeostasis
EXW27_RS29855	COG0745	RESPONSE REGULATOR receiver
EXW27_RS29860	COG5002	protein histidine kinase activity
EXW27_RS29875	COG0745	RESPONSE REGULATOR receiver
EXW27_RS29895	COG0833	amino acid
EXW27_RS29900	COG1285	pathogenesis
EXW27_RS29905	COG2267	carboxylic ester hydrolase activity
EXW27_RS29945	COG1136	(ABC) transporter
EXW27_RS29970	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW27_RS29975	COG0772	Belongs to the SEDS family
EXW27_RS29980	COG2239	Acts as a magnesium transporter
EXW27_RS29990	COG2814	Major facilitator Superfamily
EXW27_RS29995	COG0583	DNA-binding transcription factor activity
EXW27_RS30010	COG0156	8-amino-7-oxononanoate synthase activity
EXW27_RS30015	COG1760	l-serine dehydratase
EXW27_RS30020	COG4974	Belongs to the 'phage' integrase family
EXW27_RS30030	COG1073	alpha beta
EXW27_RS30065	COG1329	Transcriptional regulator
EXW27_RS30075	COG0456	acetyltransferase
EXW27_RS30100	COG4176	ABC-type proline glycine betaine transport system permease component
EXW27_RS30105	COG0517	IMP dehydrogenase activity
EXW27_RS30105	COG4175	Glycine betaine
EXW27_RS30200	COG2357	RelA SpoT domain protein
EXW27_RS30205	COG2814	Major facilitator Superfamily
EXW27_RS30210	COG1309	transcriptional regulator
EXW27_RS30220	COG0745	RESPONSE REGULATOR receiver
EXW27_RS30225	COG5002	protein histidine kinase activity
EXW27_RS30230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW27_RS30285	COG2211	Major facilitator Superfamily
EXW27_RS30305	COG0741	lytic transglycosylase activity
EXW27_RS30335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW27_RS30345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW27_RS30350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW27_RS30355	COG1999	signal sequence binding
EXW27_RS30420	COG2211	Major facilitator Superfamily
EXW27_RS30460	COG2002	toxin-antitoxin pair type II binding
EXW27_RS30635	COG1396	sequence-specific DNA binding
EXW27_RS30665	COG2801	Transposase and inactivated derivatives
EXW27_RS30675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW27_RS30680	COG4974	Belongs to the 'phage' integrase family
EXW27_RS30685	COG0024	Methionine aminopeptidase
EXW27_RS30695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW27_RS30880	COG1396	sequence-specific DNA binding
EXW27_RS30900	COG1396	sequence-specific DNA binding
EXW27_RS30995	COG3331	DNA recombination
EXW27_RS31020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW27_RS31035	COG5484	DNA packaging
EXW27_RS31040	COG1783	phage Terminase large subunit