locus-tag	class	description
EXW61_RS00190	COG1040	competence protein
EXW61_RS00195	COG1278	Cold shock
EXW61_RS00225	COG2884	Cell division ATP-binding protein ftsE
EXW61_RS00230	COG2177	Part of the ABC transporter FtsEX involved in
EXW61_RS00235	COG0793	Belongs to the peptidase S41A family
EXW61_RS00235	COG3409	Peptidoglycan-binding domain 1 protein
EXW61_RS00240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW61_RS00245	COG1132	(ABC) transporter
EXW61_RS00255	COG0488	(ABC) transporter
EXW61_RS00260	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW61_RS00265	COG0789	Transcriptional regulator
EXW61_RS00270	COG0583	DNA-binding transcription factor activity
EXW61_RS00305	COG0789	Transcriptional regulator
EXW61_RS00325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW61_RS00330	COG1950	PFAM Membrane protein of
EXW61_RS00335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW61_RS00340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW61_RS00345	COG0546	phosphoglycolate phosphatase activity
EXW61_RS00350	COG0110	maltose O-acetyltransferase activity
EXW61_RS00355	COG0457	Tetratricopeptide repeat
EXW61_RS00360	COG0492	ferredoxin-NADP+ reductase activity
EXW61_RS00370	COG1051	belongs to the nudix hydrolase family
EXW61_RS00375	COG1660	Displays ATPase and GTPase activities
EXW61_RS00380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW61_RS00385	COG1481	regulation of sporulation
EXW61_RS00390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW61_RS00400	COG2323	membrane
EXW61_RS00415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW61_RS00450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW61_RS00465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW61_RS00470	COG0126	phosphoglycerate kinase activity
EXW61_RS00475	COG0149	triose-phosphate isomerase activity
EXW61_RS00485	COG0148	phosphopyruvate hydratase activity
EXW61_RS00500	COG1346	cytolysis
EXW61_RS00505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW61_RS00510	COG1647	Serine aminopeptidase, S33
EXW61_RS00515	COG0557	exoribonuclease II activity
EXW61_RS00520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW61_RS00560	COG2233	PERMEase
EXW61_RS00565	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW61_RS00570	COG0288	reversible hydration of carbon dioxide
EXW61_RS00575	COG1522	sequence-specific DNA binding
EXW61_RS00585	COG1522	sequence-specific DNA binding
EXW61_RS00590	COG1335	isochorismatase
EXW61_RS00595	COG4224	UPF0291 protein
EXW61_RS00610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS00630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW61_RS00640	COG3290	protein histidine kinase activity
EXW61_RS00640	COG0840	transmembrane signaling receptor activity
EXW61_RS00660	COG1252	NADH dehydrogenase
EXW61_RS00670	COG1733	regulation of RNA biosynthetic process
EXW61_RS00675	COG2814	Major facilitator Superfamily
EXW61_RS00680	COG0656	L-ascorbic acid biosynthetic process
EXW61_RS00695	COG2910	NAD(P)H-binding
EXW61_RS00700	COG1115	amino acid carrier protein
EXW61_RS00705	COG1115	amino acid carrier protein
EXW61_RS00710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS00715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS00725	COG1528	Iron-storage protein
EXW61_RS00735	COG1611	Belongs to the LOG family
EXW61_RS00740	COG2318	DinB family
EXW61_RS00750	COG0783	Belongs to the Dps family
EXW61_RS00755	COG1115	amino acid carrier protein
EXW61_RS00760	COG0490	domain, Protein
EXW61_RS00765	COG0475	glutathione-regulated potassium exporter activity
EXW61_RS00770	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS00785	COG1741	Belongs to the pirin family
EXW61_RS00790	COG3227	Zinc metalloprotease (Elastase)
EXW61_RS00795	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW61_RS00800	COG0840	transmembrane signaling receptor activity
EXW61_RS00805	COG0840	transmembrane signaling receptor activity
EXW61_RS00815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW61_RS00825	COG5002	protein histidine kinase activity
EXW61_RS00830	COG0745	RESPONSE REGULATOR receiver
EXW61_RS00835	COG1376	ErfK ybiS ycfS ynhG family protein
EXW61_RS00845	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS00875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS00900	COG0531	amino acid
EXW61_RS00905	COG2814	Major facilitator Superfamily
EXW61_RS00920	COG0840	transmembrane signaling receptor activity
EXW61_RS00925	COG0011	TIGRFAM Protein of
EXW61_RS00935	COG0506	proline dehydrogenase activity
EXW61_RS00940	COG1686	Belongs to the peptidase S11 family
EXW61_RS00950	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW61_RS00950	COG1024	Enoyl-CoA hydratase
EXW61_RS00955	COG0183	Belongs to the thiolase family
EXW61_RS00960	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS00965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS00970	COG1309	transcriptional regulator
EXW61_RS01020	COG1393	Belongs to the ArsC family
EXW61_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
EXW61_RS01035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW61_RS01040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS01050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW61_RS01055	COG2011	ABC-type metal ion transport system permease component
EXW61_RS01060	COG1464	Belongs to the NlpA lipoprotein family
EXW61_RS01065	COG1464	Belongs to the NlpA lipoprotein family
EXW61_RS01070	COG0396	ATPase activity
EXW61_RS01075	COG0719	Fe-S assembly protein
EXW61_RS01080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW61_RS01085	COG0822	iron-sulfur transferase activity
EXW61_RS01090	COG0719	Fe-S assembly protein
EXW61_RS01095	COG0737	Belongs to the 5'-nucleotidase family
EXW61_RS01100	COG3377	Domain of unknown function (DUF1805)
EXW61_RS01110	COG0739	heme binding
EXW61_RS01115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW61_RS01135	COG4377	Putative membrane peptidase family (DUF2324)
EXW61_RS01140	COG0789	Transcriptional regulator
EXW61_RS01150	COG4470	Protein conserved in bacteria
EXW61_RS01170	COG1494	fructose-1,6-bisphosphatase
EXW61_RS01175	COG2445	Protein of unknown function DUF86
EXW61_RS01185	COG0647	UMP catabolic process
EXW61_RS01200	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW61_RS01220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW61_RS01225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW61_RS01235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW61_RS01240	COG4837	Protein of unknown function (DUF1462)
EXW61_RS01265	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW61_RS01270	COG0390	transport system, permease component
EXW61_RS01280	COG1252	NADH dehydrogenase
EXW61_RS01285	COG4844	belongs to the
EXW61_RS01290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW61_RS01295	COG0316	Belongs to the HesB IscA family
EXW61_RS01315	COG1683	Conserved Protein
EXW61_RS01330	COG3708	Transcriptional regulator
EXW61_RS01335	COG0492	ferredoxin-NADP+ reductase activity
EXW61_RS01340	COG1252	NADH dehydrogenase
EXW61_RS01355	COG3584	3D domain protein
EXW61_RS01360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW61_RS01370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW61_RS01375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW61_RS01380	COG1268	BioY protein
EXW61_RS01390	COG2050	protein possibly involved in aromatic compounds catabolism
EXW61_RS01410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW61_RS01415	COG5018	Exonuclease
EXW61_RS01435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW61_RS01445	COG2267	carboxylic ester hydrolase activity
EXW61_RS01450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW61_RS01455	COG1522	sequence-specific DNA binding
EXW61_RS01460	COG0436	Aminotransferase
EXW61_RS01465	COG1098	S1 RNA binding domain
EXW61_RS01470	COG2155	Conserved Protein
EXW61_RS01475	COG0166	Belongs to the GPI family
EXW61_RS01485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW61_RS01490	COG1285	pathogenesis
EXW61_RS01625	COG1595	DNA-templated transcription, initiation
EXW61_RS01650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW61_RS01655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW61_RS01660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW61_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
EXW61_RS01690	COG1278	Cold shock
EXW61_RS01695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW61_RS01700	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW61_RS01705	COG1169	isochorismate synthase
EXW61_RS01710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW61_RS01715	COG0596	Alpha beta hydrolase
EXW61_RS01720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW61_RS01725	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS01730	COG4948	Mandelate Racemase Muconate Lactonizing
EXW61_RS01750	COG3964	amidohydrolase
EXW61_RS01770	COG2188	Transcriptional regulator
EXW61_RS01785	COG0577	efflux transmembrane transporter activity
EXW61_RS01790	COG1136	(ABC) transporter
EXW61_RS01795	COG0577	efflux transmembrane transporter activity
EXW61_RS01800	COG0577	efflux transmembrane transporter activity
EXW61_RS01805	COG2205	protein histidine kinase activity
EXW61_RS01810	COG0745	RESPONSE REGULATOR receiver
EXW61_RS01815	COG0640	Transcriptional regulator
EXW61_RS01820	COG5658	integral membrane protein
EXW61_RS01825	COG1131	(ABC) transporter
EXW61_RS01835	COG3708	Transcriptional regulator
EXW61_RS01835	COG2207	Transcriptional regulator
EXW61_RS01840	COG1136	(ABC) transporter
EXW61_RS01845	COG0577	efflux transmembrane transporter activity
EXW61_RS01860	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS01870	COG5002	protein histidine kinase activity
EXW61_RS01900	COG1136	(ABC) transporter
EXW61_RS01915	COG1597	lipid kinase activity
EXW61_RS01920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW61_RS01945	COG0745	RESPONSE REGULATOR receiver
EXW61_RS01950	COG5002	protein histidine kinase activity
EXW61_RS01955	COG3859	Proton-coupled thiamine transporter YuaJ
EXW61_RS01980	COG1842	Phage shock protein A
EXW61_RS02005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS02020	COG1294	oxidase, subunit
EXW61_RS02025	COG1271	oxidase subunit
EXW61_RS02030	COG0288	reversible hydration of carbon dioxide
EXW61_RS02040	COG1854	S-ribosylhomocysteine lyase activity
EXW61_RS02070	COG0494	nUDIX hydrolase
EXW61_RS02095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW61_RS02100	COG1116	anion transmembrane transporter activity
EXW61_RS02105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW61_RS02120	COG4895	conserved protein (DUF2196)
EXW61_RS02130	COG1368	sulfuric ester hydrolase activity
EXW61_RS02140	COG2267	carboxylic ester hydrolase activity
EXW61_RS02145	COG0753	catalase activity
EXW61_RS02150	COG3852	Histidine kinase
EXW61_RS02155	COG5002	protein histidine kinase activity
EXW61_RS02180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW61_RS02185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW61_RS02205	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS02210	COG0671	phosphoesterase, PA-phosphatase related
EXW61_RS02215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW61_RS02220	COG2267	carboxylic ester hydrolase activity
EXW61_RS02235	COG1794	racemase activity, acting on amino acids and derivatives
EXW61_RS02245	COG1131	(ABC) transporter
EXW61_RS02250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW61_RS02255	COG1242	4 iron, 4 sulfur cluster binding
EXW61_RS02270	COG1136	(ABC) transporter
EXW61_RS02280	COG0582	viral genome integration into host DNA
EXW61_RS02285	COG0490	domain, Protein
EXW61_RS02290	COG0475	glutathione-regulated potassium exporter activity
EXW61_RS02295	COG2814	Major facilitator Superfamily
EXW61_RS02300	COG0495	leucyl-tRNA aminoacylation
EXW61_RS02340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW61_RS02350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS02370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW61_RS02375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW61_RS02380	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW61_RS02385	COG0303	'Molybdopterin
EXW61_RS02390	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW61_RS02395	COG0314	molybdopterin synthase activity
EXW61_RS02420	COG1329	Transcriptional regulator
EXW61_RS02440	COG3832	glyoxalase III activity
EXW61_RS02450	COG2814	Major facilitator Superfamily
EXW61_RS02455	COG2081	HI0933 family
EXW61_RS02460	COG2244	polysaccharide biosynthetic process
EXW61_RS02465	COG1187	pseudouridine synthase activity
EXW61_RS02470	COG1349	DNA-binding transcription factor activity
EXW61_RS02475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW61_RS02485	COG1523	belongs to the glycosyl hydrolase 13 family
EXW61_RS02490	COG0510	thiamine kinase activity
EXW61_RS02500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW61_RS02505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS02515	COG1363	Peptidase, m42
EXW61_RS02520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW61_RS02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS02530	COG4848	Belongs to the UPF0354 family
EXW61_RS02535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW61_RS02550	COG1674	ftsk spoiiie
EXW61_RS02560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW61_RS02565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS02585	COG2309	aminopeptidase activity
EXW61_RS02595	COG3118	belongs to the thioredoxin family
EXW61_RS02600	COG4851	CamS sex pheromone cAM373 precursor
EXW61_RS02615	COG1609	Transcriptional regulator
EXW61_RS02640	COG1970	mechanosensitive ion channel activity
EXW61_RS02650	COG0666	response to abiotic stimulus
EXW61_RS02655	COG5002	protein histidine kinase activity
EXW61_RS02660	COG0745	RESPONSE REGULATOR receiver
EXW61_RS02675	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW61_RS02680	COG0517	IMP dehydrogenase activity
EXW61_RS02685	COG0454	-acetyltransferase
EXW61_RS02690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW61_RS02695	COG0110	maltose O-acetyltransferase activity
EXW61_RS02705	COG1595	DNA-templated transcription, initiation
EXW61_RS02760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW61_RS02770	COG0626	cystathionine gamma-synthase activity
EXW61_RS02775	COG1956	GAF domain-containing protein
EXW61_RS02780	COG1309	transcriptional regulator
EXW61_RS02790	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW61_RS02795	COG1104	cysteine desulfurase activity
EXW61_RS02810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW61_RS02820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW61_RS02835	COG3874	Sporulation protein YtfJ
EXW61_RS02840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW61_RS02845	COG0827	DNA restriction-modification system
EXW61_RS02850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW61_RS02870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS02885	COG0137	argininosuccinate synthase activity
EXW61_RS02915	COG0589	response to stress
EXW61_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS02935	COG1476	TRANSCRIPTIONal
EXW61_RS02945	COG0662	Cupin 2, conserved barrel domain protein
EXW61_RS02985	COG0006	proline dipeptidase activity
EXW61_RS02990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW61_RS03000	COG4109	DRTGG domain
EXW61_RS03015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW61_RS03030	COG0587	DNA-directed DNA polymerase activity
EXW61_RS03035	COG0281	malic enzyme
EXW61_RS03040	COG1725	Transcriptional regulator
EXW61_RS03045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW61_RS03055	COG0205	6-phosphofructokinase activity
EXW61_RS03065	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW61_RS03070	COG0628	permease
EXW61_RS03080	COG0372	Belongs to the citrate synthase family
EXW61_RS03085	COG0538	isocitrate dehydrogenase activity
EXW61_RS03090	COG0039	L-malate dehydrogenase activity
EXW61_RS03105	COG0745	RESPONSE REGULATOR receiver
EXW61_RS03110	COG5002	protein histidine kinase activity
EXW61_RS03115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW61_RS03115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW61_RS03125	COG1971	Probably functions as a manganese efflux pump
EXW61_RS03130	COG0237	dephospho-CoA kinase activity
EXW61_RS03135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW61_RS03140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW61_RS03145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW61_RS03150	COG3611	Membrane attachment protein
EXW61_RS03155	COG1484	DNA-dependent DNA replication
EXW61_RS03165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW61_RS03180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW61_RS03190	COG1363	Peptidase, m42
EXW61_RS03195	COG1309	transcriptional regulator
EXW61_RS03200	COG1566	PFAM secretion protein HlyD family protein
EXW61_RS03205	COG2814	Major facilitator Superfamily
EXW61_RS03225	COG1418	mRNA catabolic process
EXW61_RS03235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW61_RS03240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW61_RS03265	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW61_RS03270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW61_RS03275	COG1286	toxin biosynthetic process
EXW61_RS03280	COG1796	DNA polymerase
EXW61_RS03280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW61_RS03285	COG1193	negative regulation of DNA recombination
EXW61_RS03295	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS03300	COG5386	Cell surface protein
EXW61_RS03305	COG5386	Cell surface protein
EXW61_RS03320	COG1120	ATPase activity
EXW61_RS03325	COG4509	Sortase family
EXW61_RS03330	COG2329	Antibiotic biosynthesis monooxygenase
EXW61_RS03335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW61_RS03340	COG4895	conserved protein (DUF2196)
EXW61_RS03350	COG0745	RESPONSE REGULATOR receiver
EXW61_RS03355	COG2205	protein histidine kinase activity
EXW61_RS03360	COG1131	(ABC) transporter
EXW61_RS03390	COG2318	DinB family
EXW61_RS03415	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS03420	COG1309	transcriptional regulator
EXW61_RS03425	COG1024	Enoyl-CoA hydratase
EXW61_RS03430	COG2086	electron transfer activity
EXW61_RS03435	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW61_RS03440	COG3118	belongs to the thioredoxin family
EXW61_RS03445	COG0322	excinuclease ABC activity
EXW61_RS03450	COG1719	4-vinyl reductase, 4VR
EXW61_RS03455	COG2009	succinate dehydrogenase
EXW61_RS03460	COG1053	succinate dehydrogenase
EXW61_RS03465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW61_RS03470	COG0824	Thioesterase
EXW61_RS03475	COG1876	peptidase activity
EXW61_RS03480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW61_RS03485	COG1360	Flagellar Motor Protein
EXW61_RS03490	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW61_RS03495	COG4152	abc transporter atp-binding protein
EXW61_RS03500	COG1668	transmembrane transport
EXW61_RS03505	COG1959	2 iron, 2 sulfur cluster binding
EXW61_RS03515	COG0697	spore germination
EXW61_RS03520	COG1396	sequence-specific DNA binding
EXW61_RS03525	COG1983	PspC domain protein
EXW61_RS03530	COG0402	S-adenosylhomocysteine deaminase activity
EXW61_RS03535	COG2233	PERMEase
EXW61_RS03540	COG2197	response regulator
EXW61_RS03550	COG1309	transcriptional regulator
EXW61_RS03560	COG0477	Major facilitator Superfamily
EXW61_RS03570	COG5401	PFAM Sporulation and spore germination
EXW61_RS03575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW61_RS03585	COG0622	Phosphoesterase
EXW61_RS03620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW61_RS03665	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW61_RS03675	COG0470	DNA polymerase III
EXW61_RS03675	COG1067	ATP-dependent peptidase activity
EXW61_RS03685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW61_RS03690	COG1764	response to oxidative stress
EXW61_RS03695	COG1846	Transcriptional regulator
EXW61_RS03700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW61_RS03705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW61_RS03710	COG0181	hydroxymethylbilane synthase activity
EXW61_RS03715	COG1587	Uroporphyrinogen-III synthase
EXW61_RS03720	COG0113	porphobilinogen synthase activity
EXW61_RS03725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW61_RS03730	COG1388	LysM domain
EXW61_RS03745	COG0285	dihydrofolate synthase activity
EXW61_RS03755	COG0424	maF-like protein
EXW61_RS03760	COG2003	Belongs to the UPF0758 family
EXW61_RS03765	COG1077	Cell shape determining protein MreB Mrl
EXW61_RS03780	COG0850	regulation of cytokinetic process
EXW61_RS03785	COG2894	cell division
EXW61_RS03790	COG0739	heme binding
EXW61_RS03795	COG1994	Peptidase M50
EXW61_RS03800	COG1530	ribonuclease E activity
EXW61_RS03810	COG2868	ribosomal protein
EXW61_RS03820	COG3290	protein histidine kinase activity
EXW61_RS03825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW61_RS03830	COG0745	RESPONSE REGULATOR receiver
EXW61_RS03835	COG5002	protein histidine kinase activity
EXW61_RS03840	COG1136	(ABC) transporter
EXW61_RS03845	COG0577	efflux transmembrane transporter activity
EXW61_RS03850	COG0577	efflux transmembrane transporter activity
EXW61_RS03855	COG0077	Prephenate dehydratase
EXW61_RS03860	COG2258	MOSC domain
EXW61_RS03865	COG1827	regulation of RNA biosynthetic process
EXW61_RS03870	COG1104	cysteine desulfurase activity
EXW61_RS03875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW61_RS03880	COG0157	Belongs to the NadC ModD family
EXW61_RS03885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW61_RS03910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW61_RS03915	COG0632	four-way junction helicase activity
EXW61_RS03920	COG2255	four-way junction helicase activity
EXW61_RS03930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW61_RS03935	COG0343	queuine tRNA-ribosyltransferase activity
EXW61_RS03940	COG1862	Preprotein translocase
EXW61_RS03950	COG2323	membrane
EXW61_RS03955	COG2244	polysaccharide biosynthetic process
EXW61_RS03965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW61_RS03965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW61_RS03970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW61_RS03975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW61_RS03975	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW61_RS03980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW61_RS03985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW61_RS03990	COG1490	D-aminoacyl-tRNA deacylase activity
EXW61_RS04005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW61_RS04010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW61_RS04020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW61_RS04025	COG1959	2 iron, 2 sulfur cluster binding
EXW61_RS04030	COG1104	cysteine desulfurase activity
EXW61_RS04035	COG0482	sulfurtransferase activity
EXW61_RS04045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW61_RS04065	COG0628	permease
EXW61_RS04075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW61_RS04080	COG4472	Bacterial protein of unknown function (DUF965)
EXW61_RS04085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW61_RS04095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW61_RS04100	COG4122	O-methyltransferase activity
EXW61_RS04105	COG0826	peptidase U32
EXW61_RS04110	COG0826	peptidase U32
EXW61_RS04115	COG0572	uridine kinase
EXW61_RS04120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW61_RS04125	COG0768	penicillin binding
EXW61_RS04140	COG2226	methyltransferase
EXW61_RS04145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW61_RS04150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW61_RS04155	COG0626	cystathionine gamma-synthase activity
EXW61_RS04160	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS04160	COG1454	alcohol dehydrogenase
EXW61_RS04170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS04210	COG2259	Doxx family
EXW61_RS04215	COG2514	catechol 2,3-dioxygenase activity
EXW61_RS04220	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW61_RS04225	COG3186	Phenylalanine-4-hydroxylase
EXW61_RS04230	COG1404	Belongs to the peptidase S8 family
EXW61_RS04265	COG2267	carboxylic ester hydrolase activity
EXW61_RS04275	COG1785	Belongs to the alkaline phosphatase family
EXW61_RS04285	COG2357	RelA SpoT domain protein
EXW61_RS04290	COG1595	DNA-templated transcription, initiation
EXW61_RS04300	COG0688	phosphatidylethanolamine metabolic process
EXW61_RS04310	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW61_RS04315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW61_RS04320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW61_RS04325	COG1534	Rna-binding protein
EXW61_RS04330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW61_RS04335	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW61_RS04340	COG0799	negative regulation of ribosome biogenesis
EXW61_RS04345	COG2226	methyltransferase
EXW61_RS04350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW61_RS04355	COG1555	photosystem II stabilization
EXW61_RS04355	COG1596	polysaccharide export
EXW61_RS04360	COG2131	deaminase
EXW61_RS04365	COG0658	competence protein
EXW61_RS04365	COG2333	competence protein COMEC
EXW61_RS04375	COG1466	dna polymerase III delta subunit
EXW61_RS04380	COG0268	Binds directly to 16S ribosomal RNA
EXW61_RS04385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW61_RS04395	COG0481	GTPase activity
EXW61_RS04400	COG1733	regulation of RNA biosynthetic process
EXW61_RS04405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW61_RS04410	COG1420	regulation of RNA biosynthetic process
EXW61_RS04420	COG0443	Heat shock 70 kDa protein
EXW61_RS04425	COG0484	heat shock protein binding
EXW61_RS04435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW61_RS04440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW61_RS04445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW61_RS04450	COG1610	YqeY-like protein
EXW61_RS04465	COG1702	phosphate starvation-inducible protein PhoH
EXW61_RS04470	COG1480	7TM receptor with intracellular HD hydrolase
EXW61_RS04475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW61_RS04480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW61_RS04485	COG0295	cytidine deaminase activity
EXW61_RS04490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW61_RS04500	COG1381	Involved in DNA repair and RecF pathway recombination
EXW61_RS04505	COG0517	IMP dehydrogenase activity
EXW61_RS04510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW61_RS04520	COG0358	DNA primase activity
EXW61_RS04525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW61_RS04530	COG2010	Cytochrome c
EXW61_RS04535	COG2384	SAM-dependent methyltransferase
EXW61_RS04540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW61_RS04545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW61_RS04560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW61_RS04570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS04575	COG1121	(ABC) transporter
EXW61_RS04580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW61_RS04585	COG0735	belongs to the Fur family
EXW61_RS04590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW61_RS04610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW61_RS04615	COG0477	Major facilitator Superfamily
EXW61_RS04620	COG0768	penicillin binding
EXW61_RS04625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW61_RS04630	COG0573	inorganic phosphate transmembrane transporter activity
EXW61_RS04635	COG0581	inorganic phosphate transmembrane transporter activity
EXW61_RS04645	COG0704	Plays a role in the regulation of phosphate uptake
EXW61_RS04650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW61_RS04655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW61_RS04660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW61_RS04665	COG4483	Protein conserved in bacteria
EXW61_RS04670	COG1940	carbohydrate kinase activity
EXW61_RS04680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS04695	COG0626	cystathionine gamma-synthase activity
EXW61_RS04700	COG0626	cystathionine gamma-synthase activity
EXW61_RS04705	COG0646	methionine synthase
EXW61_RS04705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW61_RS04710	COG1410	methionine synthase
EXW61_RS04710	COG0646	methionine synthase
EXW61_RS04765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW61_RS04770	COG1459	type II secretion system
EXW61_RS04780	COG4970	Tfp pilus assembly protein FimT
EXW61_RS04805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW61_RS04835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW61_RS04840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW61_RS04845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW61_RS04850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW61_RS04865	COG1725	Transcriptional regulator
EXW61_RS04900	COG2076	Multidrug Resistance protein
EXW61_RS04905	COG2076	Multidrug Resistance protein
EXW61_RS04915	COG1609	Transcriptional regulator
EXW61_RS04925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS04960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW61_RS04970	COG3872	metal-dependent enzyme
EXW61_RS04980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW61_RS04985	COG0006	proline dipeptidase activity
EXW61_RS04990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW61_RS05010	COG3854	ATPases associated with a variety of cellular activities
EXW61_RS05055	COG0511	ligase activity, forming carbon-carbon bonds
EXW61_RS05060	COG0439	Biotin carboxylase
EXW61_RS05065	COG1302	Protein conserved in bacteria
EXW61_RS05070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW61_RS05075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW61_RS05080	COG1570	exodeoxyribonuclease VII activity
EXW61_RS05085	COG1722	exodeoxyribonuclease VII activity
EXW61_RS05090	COG0142	geranyltranstransferase activity
EXW61_RS05095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW61_RS05100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW61_RS05105	COG1438	arginine binding
EXW61_RS05110	COG0497	DNA recombination
EXW61_RS05115	COG0750	zinc metalloprotease
EXW61_RS05120	COG0745	RESPONSE REGULATOR receiver
EXW61_RS05165	COG3093	addiction module antidote protein HigA
EXW61_RS05170	COG0584	glycerophosphoryl diester phosphodiesterase
EXW61_RS05180	COG3290	protein histidine kinase activity
EXW61_RS05180	COG3829	transcription factor binding
EXW61_RS05185	COG0280	phosphate acetyltransferase
EXW61_RS05195	COG3426	butyrate kinase activity
EXW61_RS05200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW61_RS05205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW61_RS05210	COG0022	dehydrogenase e1 component
EXW61_RS05215	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW61_RS05220	COG0772	Belongs to the SEDS family
EXW61_RS05225	COG2323	membrane
EXW61_RS05230	COG2816	NAD+ diphosphatase activity
EXW61_RS05240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS05245	COG0765	amino acid transport
EXW61_RS05250	COG1126	abc transporter atp-binding protein
EXW61_RS05255	COG4129	membrane
EXW61_RS05260	COG1376	ErfK ybiS ycfS ynhG family protein
EXW61_RS05275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS05280	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW61_RS05295	COG1285	pathogenesis
EXW61_RS05310	COG1234	tRNA 3'-trailer cleavage
EXW61_RS05320	COG1760	l-serine dehydratase
EXW61_RS05325	COG1760	l-serine dehydratase
EXW61_RS05330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW61_RS05335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS05340	COG0300	oxidoreductase activity
EXW61_RS05350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW61_RS05360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW61_RS05395	COG1522	sequence-specific DNA binding
EXW61_RS05405	COG0737	Belongs to the 5'-nucleotidase family
EXW61_RS05410	COG1757	Na H antiporter
EXW61_RS05420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW61_RS05430	COG0156	8-amino-7-oxononanoate synthase activity
EXW61_RS05435	COG2226	methyltransferase
EXW61_RS05435	COG1073	alpha beta
EXW61_RS05440	COG4106	trans-aconitate 2-methyltransferase activity
EXW61_RS05445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW61_RS05460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW61_RS05460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW61_RS05465	COG0307	riboflavin synthase, alpha
EXW61_RS05470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW61_RS05470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW61_RS05485	COG1073	alpha beta
EXW61_RS05490	COG0456	acetyltransferase
EXW61_RS05495	COG1609	Transcriptional regulator
EXW61_RS05500	COG2056	Na+-H+ antiporter family
EXW61_RS05505	COG0596	Alpha beta hydrolase
EXW61_RS05515	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW61_RS05520	COG4085	toxin activity
EXW61_RS05520	COG1525	nuclease
EXW61_RS05520	COG0737	Belongs to the 5'-nucleotidase family
EXW61_RS05530	COG0456	acetyltransferase
EXW61_RS05530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW61_RS05535	COG0656	L-ascorbic acid biosynthetic process
EXW61_RS05540	COG0667	Aldo Keto reductase
EXW61_RS05560	COG1300	Membrane
EXW61_RS05565	COG0735	belongs to the Fur family
EXW61_RS05575	COG4974	Belongs to the 'phage' integrase family
EXW61_RS05585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW61_RS05600	COG0598	Magnesium transport protein CorA
EXW61_RS05615	COG1846	Transcriptional regulator
EXW61_RS05645	COG1725	Transcriptional regulator
EXW61_RS05650	COG1686	Belongs to the peptidase S11 family
EXW61_RS05690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW61_RS05705	COG0697	spore germination
EXW61_RS05710	COG0561	phosphatase activity
EXW61_RS05715	COG4086	secreted protein
EXW61_RS05720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW61_RS05730	COG1547	Domain of unknown function (DUF309)
EXW61_RS05740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW61_RS05745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW61_RS05760	COG0363	glucosamine-6-phosphate deaminase activity
EXW61_RS05765	COG2188	Transcriptional regulator
EXW61_RS05775	COG3711	transcriptional antiterminator
EXW61_RS05780	COG2190	(PTS) system
EXW61_RS05780	COG1263	PTS System
EXW61_RS05780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS05805	COG0778	Nitroreductase
EXW61_RS05810	COG2199	diguanylate cyclase activity
EXW61_RS05820	COG2084	Dehydrogenase
EXW61_RS05845	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW61_RS05850	COG1850	ribulose-bisphosphate carboxylase activity
EXW61_RS05855	COG0436	Aminotransferase
EXW61_RS05860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW61_RS05865	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW61_RS05870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW61_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS05885	COG1695	Transcriptional regulator
EXW61_RS05920	COG0183	Belongs to the thiolase family
EXW61_RS05960	COG3842	ATPase activity
EXW61_RS05965	COG0366	Alpha amylase catalytic
EXW61_RS05975	COG2182	Extracellular solute-binding protein
EXW61_RS05980	COG1175	transmembrane transport
EXW61_RS05985	COG3833	ABC-type maltose transport systems, permease component
EXW61_RS05990	COG1609	Transcriptional regulator
EXW61_RS05995	COG0436	Aminotransferase
EXW61_RS06005	COG2205	protein histidine kinase activity
EXW61_RS06015	COG3209	COG3209 Rhs family protein
EXW61_RS06025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW61_RS06035	COG2814	Major facilitator Superfamily
EXW61_RS06080	COG1408	metallophosphoesterase
EXW61_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS06090	COG2200	EAL domain
EXW61_RS06105	COG4703	Protein of unknown function (DUF1797)
EXW61_RS06115	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW61_RS06125	COG0517	IMP dehydrogenase activity
EXW61_RS06130	COG0583	DNA-binding transcription factor activity
EXW61_RS06135	COG2171	N-acyltransferase activity
EXW61_RS06140	COG1473	amidohydrolase
EXW61_RS06150	COG0569	domain protein
EXW61_RS06155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW61_RS06160	COG5503	Protein of unknown function (DUF1447)
EXW61_RS06165	COG0561	phosphatase activity
EXW61_RS06180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW61_RS06185	COG0022	dehydrogenase e1 component
EXW61_RS06190	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW61_RS06235	COG1982	Orn Lys Arg decarboxylase major
EXW61_RS06240	COG4476	Belongs to the UPF0223 family
EXW61_RS06245	COG4493	Belongs to the UPF0637 family
EXW61_RS06255	COG0483	inositol monophosphate 1-phosphatase activity
EXW61_RS06265	COG1217	gtp-binding protein TYPA
EXW61_RS06280	COG4896	Protein conserved in bacteria
EXW61_RS06290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW61_RS06295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW61_RS06300	COG4838	Belongs to the UPF0358 family
EXW61_RS06305	COG0772	Belongs to the SEDS family
EXW61_RS06310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW61_RS06315	COG1612	heme a metabolic process
EXW61_RS06320	COG0109	protoheme IX farnesyltransferase activity
EXW61_RS06345	COG3336	cytochrome c oxidase
EXW61_RS06355	COG2340	Cysteine-rich secretory protein family
EXW61_RS06370	COG0406	alpha-ribazole phosphatase activity
EXW61_RS06375	COG3679	Belongs to the UPF0342 family
EXW61_RS06380	COG4471	UPF0298 protein
EXW61_RS06390	COG0742	ribosomal rna small subunit methyltransferase
EXW61_RS06395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXW61_RS06400	COG3314	Sporulation integral membrane protein YlbJ
EXW61_RS06405	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW61_RS06410	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW61_RS06415	COG1323	Belongs to the UPF0348 family
EXW61_RS06420	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW61_RS06425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW61_RS06435	COG0454	-acetyltransferase
EXW61_RS06440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW61_RS06445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW61_RS06450	COG0275	rRNA processing
EXW61_RS06460	COG0768	penicillin binding
EXW61_RS06465	COG0768	penicillin binding
EXW61_RS06470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW61_RS06475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW61_RS06480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW61_RS06485	COG0772	Belongs to the SEDS family
EXW61_RS06500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW61_RS06505	COG0849	cell division
EXW61_RS06510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW61_RS06520	COG1191	sigma factor activity
EXW61_RS06525	COG1191	sigma factor activity
EXW61_RS06530	COG1873	PFAM PRC-barrel domain
EXW61_RS06540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW61_RS06545	COG1799	cell septum assembly
EXW61_RS06550	COG0762	integral membrane protein
EXW61_RS06555	COG2302	S4 RNA-binding domain
EXW61_RS06560	COG3599	regulation of cell shape
EXW61_RS06565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW61_RS06575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW61_RS06580	COG0564	pseudouridine synthase activity
EXW61_RS06585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW61_RS06595	COG0540	Belongs to the ATCase OTCase family
EXW61_RS06600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW61_RS06610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW61_RS06615	COG0543	2 iron, 2 sulfur cluster binding
EXW61_RS06620	COG0167	dihydroorotate dehydrogenase activity
EXW61_RS06640	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW61_RS06660	COG0006	proline dipeptidase activity
EXW61_RS06675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW61_RS06680	COG1561	YicC-like family, N-terminal region
EXW61_RS06695	COG1758	RNA polymerase activity
EXW61_RS06700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW61_RS06705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW61_RS06710	COG0242	peptide deformylase activity
EXW61_RS06715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW61_RS06720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW61_RS06720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW61_RS06725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW61_RS06730	COG0631	protein serine/threonine phosphatase activity
EXW61_RS06735	COG0515	serine threonine protein kinase
EXW61_RS06735	COG2815	serine threonine protein kinase
EXW61_RS06745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW61_RS06750	COG1564	THIamine pyrophosphokinase
EXW61_RS06765	COG1302	Protein conserved in bacteria
EXW61_RS06770	COG1461	Dihydroxyacetone kinase
EXW61_RS06775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW61_RS06780	COG2050	protein possibly involved in aromatic compounds catabolism
EXW61_RS06780	COG1349	DNA-binding transcription factor activity
EXW61_RS06785	COG0416	fatty acid biosynthetic process
EXW61_RS06790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW61_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS06800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW61_RS06805	COG0571	ribonuclease III activity
EXW61_RS06810	COG1196	nuclear chromosome segregation
EXW61_RS06815	COG0552	protein localization to endoplasmic reticulum
EXW61_RS06820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW61_RS06825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW61_RS06835	COG1837	Belongs to the UPF0109 family
EXW61_RS06840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW61_RS06845	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW61_RS06850	COG0335	large ribosomal subunit rRNA binding
EXW61_RS06865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW61_RS06870	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW61_RS06875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW61_RS06880	COG0758	DNA mediated transformation
EXW61_RS06885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW61_RS06890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW61_RS06895	COG4974	Belongs to the 'phage' integrase family
EXW61_RS06900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW61_RS06905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW61_RS06910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW61_RS06915	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW61_RS06920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW61_RS06925	COG0528	UMP kinase activity
EXW61_RS06930	COG0233	cytoplasmic translational termination
EXW61_RS06940	COG4589	Belongs to the CDS family
EXW61_RS06950	COG0750	zinc metalloprotease
EXW61_RS06955	COG0442	prolyl-tRNA aminoacylation
EXW61_RS06965	COG0779	Required for maturation of 30S ribosomal subunits
EXW61_RS06970	COG0195	Participates in both transcription termination and antitermination
EXW61_RS06975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW61_RS06980	COG1358	cellular component organization or biogenesis
EXW61_RS06985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW61_RS06990	COG1550	Protein conserved in bacteria
EXW61_RS06995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW61_RS07005	COG0196	riboflavin kinase activity
EXW61_RS07015	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW61_RS07020	COG0726	polysaccharide deacetylase
EXW61_RS07025	COG0612	Peptidase, M16
EXW61_RS07030	COG1873	PFAM PRC-barrel domain
EXW61_RS07035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW61_RS07050	COG2856	Zn peptidase
EXW61_RS07060	COG0556	nucleotide-excision repair
EXW61_RS07065	COG1396	sequence-specific DNA binding
EXW61_RS07100	COG0305	Participates in initiation and elongation during chromosome replication
EXW61_RS07150	COG0582	viral genome integration into host DNA
EXW61_RS07265	COG4824	toxin secretion phage lysis holin
EXW61_RS07315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW61_RS07320	COG0527	aspartate kinase activity
EXW61_RS07330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW61_RS07335	COG0740	serine-type endopeptidase activity
EXW61_RS07345	COG1674	ftsk spoiiie
EXW61_RS07350	COG2188	Transcriptional regulator
EXW61_RS07355	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW61_RS07360	COG3845	ABC transporter
EXW61_RS07365	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW61_RS07370	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW61_RS07375	COG0612	Peptidase, M16
EXW61_RS07380	COG0612	Peptidase, M16
EXW61_RS07385	COG0300	oxidoreductase activity
EXW61_RS07400	COG1426	Protein conserved in bacteria
EXW61_RS07405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW61_RS07410	COG1058	Belongs to the CinA family
EXW61_RS07410	COG1546	Belongs to the CinA family
EXW61_RS07415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW61_RS07420	COG1418	mRNA catabolic process
EXW61_RS07425	COG1692	metallophosphoesterase
EXW61_RS07430	COG2359	stage V sporulation protein S
EXW61_RS07440	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW61_RS07440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW61_RS07445	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW61_RS07450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW61_RS07455	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW61_RS07465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW61_RS07470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW61_RS07475	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW61_RS07485	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW61_RS07490	COG1368	sulfuric ester hydrolase activity
EXW61_RS07500	COG3773	Cell wall hydrolase
EXW61_RS07505	COG0823	Involved in the tonB-independent uptake of proteins
EXW61_RS07510	COG2723	6-phospho-beta-galactosidase activity
EXW61_RS07515	COG2188	Transcriptional regulator
EXW61_RS07525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW61_RS07530	COG0596	Alpha beta hydrolase
EXW61_RS07530	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW61_RS07535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS07545	COG1346	cytolysis
EXW61_RS07595	COG3300	MHYT domain
EXW61_RS07595	COG5001	Diguanylate cyclase
EXW61_RS07600	COG0346	lactoylglutathione lyase activity
EXW61_RS07610	COG2364	Membrane
EXW61_RS07615	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW61_RS07620	COG2706	6-phosphogluconolactonase activity
EXW61_RS07625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW61_RS07630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW61_RS07635	COG2169	Transcriptional regulator
EXW61_RS07640	COG0708	Exodeoxyribonuclease III
EXW61_RS07645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS07650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS07655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS07660	COG1120	ATPase activity
EXW61_RS07665	COG2819	hydrolase of the alpha beta superfamily
EXW61_RS07670	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW61_RS07675	COG4566	intracellular signal transduction
EXW61_RS07705	COG1937	Protein conserved in bacteria
EXW61_RS07710	COG2608	mercury ion transmembrane transporter activity
EXW61_RS07715	COG2217	Heavy metal translocating P-type atpase
EXW61_RS07730	COG2116	formate transmembrane transporter activity
EXW61_RS07735	COG1408	metallophosphoesterase
EXW61_RS07740	COG1473	amidohydrolase
EXW61_RS07750	COG1113	amino acid transport
EXW61_RS07760	COG2322	membrane
EXW61_RS07765	COG1979	alcohol dehydrogenase
EXW61_RS07770	COG1349	DNA-binding transcription factor activity
EXW61_RS07775	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW61_RS07780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW61_RS07780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW61_RS07780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW61_RS07785	COG1388	LysM domain
EXW61_RS07785	COG3584	3D domain protein
EXW61_RS07795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW61_RS07815	COG0464	growth
EXW61_RS07825	COG2860	membrane
EXW61_RS07830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW61_RS07835	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW61_RS07840	COG0789	Transcriptional regulator
EXW61_RS07845	COG0174	glutamine synthetase
EXW61_RS07850	COG3944	biosynthesis protein
EXW61_RS07855	COG0489	protein tyrosine kinase activity
EXW61_RS07860	COG1086	Polysaccharide biosynthesis protein
EXW61_RS07865	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS07870	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS07875	COG1215	transferase activity, transferring glycosyl groups
EXW61_RS07885	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS07895	COG0297	glycogen (starch) synthase activity
EXW61_RS07910	COG1442	glycosyl transferase family 8
EXW61_RS07910	COG1216	Glycosyl transferase, family 2
EXW61_RS07915	COG1442	glycosyl transferase family 8
EXW61_RS07925	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW61_RS07925	COG3420	alginic acid biosynthetic process
EXW61_RS07935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW61_RS07945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW61_RS07980	COG1132	(ABC) transporter
EXW61_RS07985	COG1695	Transcriptional regulator
EXW61_RS08000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW61_RS08005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW61_RS08015	COG0737	Belongs to the 5'-nucleotidase family
EXW61_RS08020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS08030	COG3639	organic phosphonate transmembrane transporter activity
EXW61_RS08050	COG3763	UPF0154 protein
EXW61_RS08055	COG1132	(ABC) transporter
EXW61_RS08060	COG1132	(ABC) transporter
EXW61_RS08080	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS08080	COG3409	Peptidoglycan-binding domain 1 protein
EXW61_RS08090	COG0730	response to heat
EXW61_RS08105	COG1346	cytolysis
EXW61_RS08115	COG0583	DNA-binding transcription factor activity
EXW61_RS08125	COG1131	(ABC) transporter
EXW61_RS08130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW61_RS08135	COG1473	amidohydrolase
EXW61_RS08145	COG0785	Cytochrome C biogenesis protein
EXW61_RS08150	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW61_RS08170	COG2226	methyltransferase
EXW61_RS08185	COG2986	histidine ammonia-lyase
EXW61_RS08190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW61_RS08200	COG0010	Belongs to the arginase family
EXW61_RS08205	COG1329	Transcriptional regulator
EXW61_RS08210	COG1902	pentaerythritol trinitrate reductase activity
EXW61_RS08215	COG0069	glutamate synthase activity
EXW61_RS08220	COG0346	lactoylglutathione lyase activity
EXW61_RS08225	COG0400	carboxylic ester hydrolase activity
EXW61_RS08235	COG5002	protein histidine kinase activity
EXW61_RS08245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS08285	COG0830	nickel cation binding
EXW61_RS08305	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EXW61_RS08330	COG1396	sequence-specific DNA binding
EXW61_RS08345	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS08350	COG1268	BioY protein
EXW61_RS08355	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS08360	COG0183	Belongs to the thiolase family
EXW61_RS08375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW61_RS08385	COG2211	Major facilitator Superfamily
EXW61_RS08415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW61_RS08420	COG2274	protein secretion by the type I secretion system
EXW61_RS08445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS08470	COG0824	Thioesterase
EXW61_RS08475	COG4841	protein insertion into membrane
EXW61_RS08485	COG1328	CTP reductase activity
EXW61_RS08485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW61_RS08495	COG0745	RESPONSE REGULATOR receiver
EXW61_RS08500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW61_RS08505	COG1832	CoA-binding protein
EXW61_RS08510	COG0187	DNA topoisomerase II activity
EXW61_RS08515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW61_RS08520	COG0673	inositol 2-dehydrogenase activity
EXW61_RS08540	COG1131	(ABC) transporter
EXW61_RS08550	COG4166	transmembrane transport
EXW61_RS08555	COG4166	transmembrane transport
EXW61_RS08560	COG4166	transmembrane transport
EXW61_RS08565	COG2226	methyltransferase
EXW61_RS08595	COG0531	amino acid
EXW61_RS08600	COG3326	Membrane
EXW61_RS08605	COG2962	Rard protein
EXW61_RS08610	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW61_RS08615	COG1657	PFAM Prenyltransferase squalene oxidase
EXW61_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS08630	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS08640	COG4145	pantothenate transmembrane transporter activity
EXW61_RS08655	COG0165	Argininosuccinate lyase
EXW61_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS08685	COG0494	nUDIX hydrolase
EXW61_RS08695	COG0716	FMN binding
EXW61_RS08705	COG1278	Cold shock
EXW61_RS08730	COG2720	vancomycin resistance protein
EXW61_RS08735	COG0765	amino acid transport
EXW61_RS08740	COG1126	abc transporter atp-binding protein
EXW61_RS08745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS08750	COG2514	catechol 2,3-dioxygenase activity
EXW61_RS08760	COG1285	pathogenesis
EXW61_RS08780	COG0277	FAD linked oxidase domain protein
EXW61_RS08790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW61_RS08795	COG2808	Putative FMN-binding domain
EXW61_RS08800	COG0457	Tetratricopeptide repeat
EXW61_RS08810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW61_RS08815	COG0604	alcohol dehydrogenase
EXW61_RS08820	COG0640	Transcriptional regulator
EXW61_RS08890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS08905	COG3781	membrane
EXW61_RS08930	COG1164	Oligoendopeptidase f
EXW61_RS08935	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW61_RS08945	COG1193	negative regulation of DNA recombination
EXW61_RS08965	COG0583	DNA-binding transcription factor activity
EXW61_RS08985	COG3739	integral membrane protein
EXW61_RS08990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS08995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS09000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS09020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW61_RS09025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW61_RS09055	COG2814	Major facilitator Superfamily
EXW61_RS09065	COG1113	amino acid transport
EXW61_RS09070	COG0604	alcohol dehydrogenase
EXW61_RS09075	COG1695	Transcriptional regulator
EXW61_RS09120	COG2072	flavoprotein involved in K transport
EXW61_RS09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS09160	COG1151	hydroxylamine reductase activity
EXW61_RS09185	COG0814	amino acid
EXW61_RS09210	COG1280	lysine exporter protein (LysE YggA)
EXW61_RS09215	COG3226	Transcriptional regulator
EXW61_RS09235	COG1309	transcriptional regulator
EXW61_RS09240	COG2814	Major facilitator Superfamily
EXW61_RS09250	COG0657	acetylesterase activity
EXW61_RS09270	COG5002	protein histidine kinase activity
EXW61_RS09290	COG0741	lytic transglycosylase activity
EXW61_RS09315	COG1876	peptidase activity
EXW61_RS09335	COG1191	sigma factor activity
EXW61_RS09350	COG1733	regulation of RNA biosynthetic process
EXW61_RS09355	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW61_RS09360	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS09395	COG0494	nUDIX hydrolase
EXW61_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS09420	COG1393	Belongs to the ArsC family
EXW61_RS09440	COG0814	amino acid
EXW61_RS09455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW61_RS09460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW61_RS09470	COG1070	Carbohydrate kinase
EXW61_RS09475	COG2706	6-phosphogluconolactonase activity
EXW61_RS09480	COG3813	Protein conserved in bacteria
EXW61_RS09485	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW61_RS09490	COG0697	spore germination
EXW61_RS09515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW61_RS09525	COG0789	Transcriptional regulator
EXW61_RS09530	COG1253	flavin adenine dinucleotide binding
EXW61_RS09540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW61_RS09575	COG2261	transglycosylase associated protein
EXW61_RS09580	COG0628	permease
EXW61_RS09595	COG0110	maltose O-acetyltransferase activity
EXW61_RS09600	COG0738	Major facilitator superfamily
EXW61_RS09605	COG1940	carbohydrate kinase activity
EXW61_RS09610	COG0346	lactoylglutathione lyase activity
EXW61_RS09635	COG2365	Tyrosine phosphatase family
EXW61_RS09640	COG1011	Hydrolase
EXW61_RS09655	COG1595	DNA-templated transcription, initiation
EXW61_RS09685	COG1131	(ABC) transporter
EXW61_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS09710	COG1733	regulation of RNA biosynthetic process
EXW61_RS09715	COG0778	Nitroreductase
EXW61_RS09720	COG1785	Belongs to the alkaline phosphatase family
EXW61_RS09740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW61_RS09760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW61_RS09765	COG2356	endonuclease I
EXW61_RS09830	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW61_RS09840	COG2031	fatty acid transporter
EXW61_RS09855	COG4187	Peptidase family M20/M25/M40
EXW61_RS09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS09965	COG1609	Transcriptional regulator
EXW61_RS09970	COG2814	Major facilitator Superfamily
EXW61_RS09975	COG0673	inositol 2-dehydrogenase activity
EXW61_RS10000	COG0191	fructose-bisphosphate aldolase activity
EXW61_RS10005	COG3718	enzyme involved in inositol metabolism
EXW61_RS10050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW61_RS10055	COG1288	antiporter activity
EXW61_RS10070	COG1476	TRANSCRIPTIONal
EXW61_RS10105	COG0789	Transcriptional regulator
EXW61_RS10125	COG2814	Major facilitator Superfamily
EXW61_RS10130	COG1846	Transcriptional regulator
EXW61_RS10145	COG0477	Major facilitator Superfamily
EXW61_RS10160	COG2843	Capsule synthesis protein
EXW61_RS10165	COG1876	peptidase activity
EXW61_RS10285	COG2814	Major facilitator Superfamily
EXW61_RS10310	COG2197	response regulator
EXW61_RS10335	COG4977	sequence-specific DNA binding
EXW61_RS10360	COG5002	protein histidine kinase activity
EXW61_RS10370	COG0745	RESPONSE REGULATOR receiver
EXW61_RS10375	COG5002	protein histidine kinase activity
EXW61_RS10385	COG1760	l-serine dehydratase
EXW61_RS10390	COG1760	l-serine dehydratase
EXW61_RS10395	COG0814	amino acid
EXW61_RS10475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW61_RS10510	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW61_RS10525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS10540	COG3850	Histidine kinase
EXW61_RS10540	COG5002	protein histidine kinase activity
EXW61_RS10555	COG0577	efflux transmembrane transporter activity
EXW61_RS10560	COG1136	(ABC) transporter
EXW61_RS10580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW61_RS10595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW61_RS10605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW61_RS10625	COG1476	TRANSCRIPTIONal
EXW61_RS10650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW61_RS10680	COG5002	protein histidine kinase activity
EXW61_RS10680	COG3850	Histidine kinase
EXW61_RS10685	COG0745	RESPONSE REGULATOR receiver
EXW61_RS10715	COG2814	Major facilitator Superfamily
EXW61_RS10725	COG2226	methyltransferase
EXW61_RS10745	COG0346	lactoylglutathione lyase activity
EXW61_RS10760	COG1522	sequence-specific DNA binding
EXW61_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS10770	COG1309	transcriptional regulator
EXW61_RS10775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW61_RS10775	COG3320	Male sterility
EXW61_RS10785	COG0825	malonyl-CoA metabolic process
EXW61_RS10810	COG0640	Transcriptional regulator
EXW61_RS10815	COG0346	lactoylglutathione lyase activity
EXW61_RS10820	COG0798	PFAM Bile acid sodium symporter
EXW61_RS10850	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW61_RS10885	COG1073	alpha beta
EXW61_RS10930	COG2211	Major facilitator Superfamily
EXW61_RS10955	COG2309	aminopeptidase activity
EXW61_RS10970	COG0456	acetyltransferase
EXW61_RS10975	COG0583	DNA-binding transcription factor activity
EXW61_RS10985	COG1136	(ABC) transporter
EXW61_RS11010	COG3848	Pyruvate phosphate dikinase
EXW61_RS11010	COG0574	Belongs to the PEP-utilizing enzyme family
EXW61_RS11025	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW61_RS11045	COG3314	Sporulation integral membrane protein YlbJ
EXW61_RS11055	COG0640	Transcriptional regulator
EXW61_RS11080	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS11100	COG1414	Transcriptional regulator
EXW61_RS11105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW61_RS11110	COG1984	allophanate hydrolase subunit 2
EXW61_RS11115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW61_RS11130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW61_RS11135	COG3104	oligopeptide transport
EXW61_RS11145	COG0768	penicillin binding
EXW61_RS11175	COG4335	DNA alkylation repair
EXW61_RS11185	COG0833	amino acid
EXW61_RS11195	COG0730	response to heat
EXW61_RS11220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW61_RS11220	COG0456	acetyltransferase
EXW61_RS11250	COG0697	spore germination
EXW61_RS11255	COG0814	amino acid
EXW61_RS11280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS11285	COG0697	spore germination
EXW61_RS11300	COG0456	acetyltransferase
EXW61_RS11305	COG2207	Transcriptional regulator
EXW61_RS11330	COG3831	ATPase activity
EXW61_RS11330	COG4884	unkown
EXW61_RS11350	COG1846	Transcriptional regulator
EXW61_RS11355	COG0778	Nitroreductase
EXW61_RS11375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW61_RS11385	COG0753	catalase activity
EXW61_RS11390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW61_RS11410	COG0714	Associated with various cellular activities
EXW61_RS11435	COG0346	lactoylglutathione lyase activity
EXW61_RS11440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS11485	COG3655	Transcriptional regulator
EXW61_RS11500	COG3239	Fatty acid desaturase
EXW61_RS11505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW61_RS11510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW61_RS11515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW61_RS11525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS11555	COG2329	Antibiotic biosynthesis monooxygenase
EXW61_RS11560	COG0346	lactoylglutathione lyase activity
EXW61_RS11575	COG2226	methyltransferase
EXW61_RS11590	COG1070	Carbohydrate kinase
EXW61_RS11595	COG2390	Transcriptional regulator
EXW61_RS11615	COG1879	ABC-type sugar transport system periplasmic component
EXW61_RS11620	COG0579	oxidoreductase
EXW61_RS11650	COG0431	NADPH-dependent FMN reductase
EXW61_RS11660	COG0346	lactoylglutathione lyase activity
EXW61_RS11670	COG3584	3D domain protein
EXW61_RS11670	COG1388	LysM domain
EXW61_RS11720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EXW61_RS11720	COG2308	Evidence 4 Homologs of previously reported genes of
EXW61_RS11740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW61_RS11740	COG1605	Chorismate mutase
EXW61_RS11755	COG0287	Prephenate dehydrogenase
EXW61_RS11770	COG1309	transcriptional regulator
EXW61_RS11775	COG2409	Drug exporters of the RND superfamily
EXW61_RS11775	COG1033	growth of symbiont in host cell
EXW61_RS11780	COG0488	(ABC) transporter
EXW61_RS11785	COG1368	sulfuric ester hydrolase activity
EXW61_RS11790	COG2814	Major facilitator Superfamily
EXW61_RS11835	COG2318	DinB family
EXW61_RS11840	COG0697	spore germination
EXW61_RS11850	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW61_RS11895	COG0628	permease
EXW61_RS11940	COG2188	Transcriptional regulator
EXW61_RS11945	COG1131	(ABC) transporter
EXW61_RS11975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW61_RS11980	COG0436	Aminotransferase
EXW61_RS12015	COG2226	methyltransferase
EXW61_RS12030	COG2261	transglycosylase associated protein
EXW61_RS12050	COG0477	Major facilitator Superfamily
EXW61_RS12050	COG2814	Major facilitator Superfamily
EXW61_RS12055	COG4533	DNA binding
EXW61_RS12060	COG0789	Transcriptional regulator
EXW61_RS12065	COG1664	Polymer-forming cytoskeletal
EXW61_RS12075	COG2814	Major facilitator Superfamily
EXW61_RS12090	COG1335	isochorismatase
EXW61_RS12115	COG1307	EDD domain protein, DegV family
EXW61_RS12130	COG0745	RESPONSE REGULATOR receiver
EXW61_RS12140	COG2936	dipeptidyl-peptidase activity
EXW61_RS12185	COG0667	Aldo Keto reductase
EXW61_RS12205	COG4948	Mandelate Racemase Muconate Lactonizing
EXW61_RS12215	COG4166	transmembrane transport
EXW61_RS12220	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW61_RS12235	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS12275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW61_RS12280	COG3938	Belongs to the proline racemase family
EXW61_RS12290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW61_RS12295	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS12300	COG1115	amino acid carrier protein
EXW61_RS12305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW61_RS12325	COG2318	DinB family
EXW61_RS12330	COG3397	chitin binding
EXW61_RS12335	COG1227	inorganic diphosphatase activity
EXW61_RS12345	COG4637	Psort location Cytoplasmic, score
EXW61_RS12370	COG0514	ATP-dependent DNA helicase (RecQ)
EXW61_RS12375	COG2105	PFAM AIG2 family protein
EXW61_RS12385	COG3973	AAA domain
EXW61_RS12430	COG2315	Protein conserved in bacteria
EXW61_RS12435	COG2205	protein histidine kinase activity
EXW61_RS12450	COG1819	glycosyl
EXW61_RS12460	COG3397	chitin binding
EXW61_RS12480	COG2153	protein acetylation
EXW61_RS12485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW61_RS12510	COG4175	Glycine betaine
EXW61_RS12510	COG0517	IMP dehydrogenase activity
EXW61_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS12560	COG2223	nitrite transmembrane transporter activity
EXW61_RS12570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW61_RS12575	COG0022	dehydrogenase e1 component
EXW61_RS12580	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW61_RS12585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW61_RS12605	COG1959	2 iron, 2 sulfur cluster binding
EXW61_RS12625	COG1349	DNA-binding transcription factor activity
EXW61_RS12640	COG3284	Transcriptional regulator
EXW61_RS12655	COG1309	transcriptional regulator
EXW61_RS12660	COG3844	kynureninase activity
EXW61_RS12665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW61_RS12670	COG3483	tryptophan 2,3-dioxygenase activity
EXW61_RS12695	COG2959	enzyme of heme biosynthesis
EXW61_RS12745	COG3773	Cell wall hydrolase
EXW61_RS12755	COG0745	RESPONSE REGULATOR receiver
EXW61_RS12760	COG2205	protein histidine kinase activity
EXW61_RS12765	COG0583	DNA-binding transcription factor activity
EXW61_RS12770	COG0667	Aldo Keto reductase
EXW61_RS12775	COG0488	(ABC) transporter
EXW61_RS12785	COG1136	(ABC) transporter
EXW61_RS12790	COG0577	efflux transmembrane transporter activity
EXW61_RS12810	COG0460	homoserine dehydrogenase
EXW61_RS12815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS12825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW61_RS12835	COG0582	viral genome integration into host DNA
EXW61_RS12850	COG1396	sequence-specific DNA binding
EXW61_RS12880	COG1484	DNA-dependent DNA replication
EXW61_RS12970	COG0582	viral genome integration into host DNA
EXW61_RS13015	COG1802	Transcriptional regulator
EXW61_RS13015	COG4626	Terminase
EXW61_RS13030	COG0740	serine-type endopeptidase activity
EXW61_RS13110	COG1533	DNA photolyase activity
EXW61_RS13125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW61_RS13175	COG2124	cytochrome p450
EXW61_RS13220	COG0561	phosphatase activity
EXW61_RS13225	COG5002	protein histidine kinase activity
EXW61_RS13230	COG0768	penicillin binding
EXW61_RS13240	COG1819	glycosyl
EXW61_RS13245	COG1794	racemase activity, acting on amino acids and derivatives
EXW61_RS13250	COG4720	Psort location CytoplasmicMembrane, score
EXW61_RS13255	COG1122	ATPase activity
EXW61_RS13280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW61_RS13290	COG0745	RESPONSE REGULATOR receiver
EXW61_RS13295	COG5002	protein histidine kinase activity
EXW61_RS13300	COG0604	alcohol dehydrogenase
EXW61_RS13305	COG0671	phosphoesterase, PA-phosphatase related
EXW61_RS13310	COG0768	penicillin binding
EXW61_RS13365	COG0584	glycerophosphoryl diester phosphodiesterase
EXW61_RS13380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS13385	COG0697	spore germination
EXW61_RS13405	COG0494	nUDIX hydrolase
EXW61_RS13415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS13425	COG2223	nitrite transmembrane transporter activity
EXW61_RS13435	COG2816	NAD+ diphosphatase activity
EXW61_RS13440	COG0592	DNA-directed DNA polymerase activity
EXW61_RS13445	COG1051	belongs to the nudix hydrolase family
EXW61_RS13465	COG3878	Protein conserved in bacteria
EXW61_RS13485	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW61_RS13500	COG2318	DinB family
EXW61_RS13525	COG0322	excinuclease ABC activity
EXW61_RS13545	COG3961	Belongs to the TPP enzyme family
EXW61_RS13555	COG1132	(ABC) transporter
EXW61_RS13565	COG1183	phosphatidylcholine synthase activity
EXW61_RS13570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW61_RS13595	COG1011	Hydrolase
EXW61_RS13605	COG0745	RESPONSE REGULATOR receiver
EXW61_RS13610	COG5002	protein histidine kinase activity
EXW61_RS13640	COG1136	(ABC) transporter
EXW61_RS13645	COG0577	efflux transmembrane transporter activity
EXW61_RS13655	COG1073	alpha beta
EXW61_RS13660	COG0657	acetylesterase activity
EXW61_RS13665	COG0076	glutamate decarboxylase activity
EXW61_RS13680	COG1523	belongs to the glycosyl hydrolase 13 family
EXW61_RS13685	COG3227	Zinc metalloprotease (Elastase)
EXW61_RS13690	COG0737	Belongs to the 5'-nucleotidase family
EXW61_RS13700	COG0201	protein transport
EXW61_RS13720	COG0697	spore germination
EXW61_RS13725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS13740	COG2323	membrane
EXW61_RS13775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS13780	COG0697	spore germination
EXW61_RS13795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW61_RS13810	COG1309	transcriptional regulator
EXW61_RS13835	COG1733	regulation of RNA biosynthetic process
EXW61_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS13865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW61_RS13890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW61_RS13915	COG1686	Belongs to the peptidase S11 family
EXW61_RS13970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW61_RS13975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW61_RS13980	COG1024	Enoyl-CoA hydratase
EXW61_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW61_RS13990	COG0511	ligase activity, forming carbon-carbon bonds
EXW61_RS13995	COG0439	Biotin carboxylase
EXW61_RS14000	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS14010	COG1309	transcriptional regulator
EXW61_RS14020	COG1131	(ABC) transporter
EXW61_RS14030	COG1408	metallophosphoesterase
EXW61_RS14040	COG0823	Involved in the tonB-independent uptake of proteins
EXW61_RS14045	COG3397	chitin binding
EXW61_RS14075	COG0697	spore germination
EXW61_RS14090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW61_RS14105	COG2239	Acts as a magnesium transporter
EXW61_RS14115	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS14165	COG2197	response regulator
EXW61_RS14190	COG2723	6-phospho-beta-galactosidase activity
EXW61_RS14205	COG1136	(ABC) transporter
EXW61_RS14225	COG0577	efflux transmembrane transporter activity
EXW61_RS14230	COG1136	(ABC) transporter
EXW61_RS14250	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW61_RS14250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS14265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS14265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS14270	COG1252	NADH dehydrogenase
EXW61_RS14305	COG0768	penicillin binding
EXW61_RS14310	COG0768	penicillin binding
EXW61_RS14320	COG1595	DNA-templated transcription, initiation
EXW61_RS14330	COG0577	efflux transmembrane transporter activity
EXW61_RS14335	COG1136	(ABC) transporter
EXW61_RS14340	COG2205	protein histidine kinase activity
EXW61_RS14345	COG0745	RESPONSE REGULATOR receiver
EXW61_RS14350	COG0768	penicillin binding
EXW61_RS14375	COG1686	Belongs to the peptidase S11 family
EXW61_RS14400	COG1136	(ABC) transporter
EXW61_RS14405	COG0110	maltose O-acetyltransferase activity
EXW61_RS14415	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW61_RS14435	COG0588	phosphoglycerate mutase activity
EXW61_RS14450	COG0500	methyltransferase
EXW61_RS14450	COG3615	Tellurite resistance protein tehB
EXW61_RS14500	COG2971	BadF BadG BcrA BcrD
EXW61_RS14505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW61_RS14525	COG1649	PFAM Uncharacterised BCR, COG1649
EXW61_RS14550	COG1595	DNA-templated transcription, initiation
EXW61_RS14555	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW61_RS14565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW61_RS14595	COG1396	sequence-specific DNA binding
EXW61_RS14615	COG1132	(ABC) transporter
EXW61_RS14620	COG1132	(ABC) transporter
EXW61_RS14635	COG2258	MOSC domain
EXW61_RS14640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS14645	COG0583	DNA-binding transcription factor activity
EXW61_RS14660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW61_RS14665	COG0583	DNA-binding transcription factor activity
EXW61_RS14695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS14705	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW61_RS14710	COG0596	Alpha beta hydrolase
EXW61_RS14740	COG1247	-acetyltransferase
EXW61_RS14770	COG1309	transcriptional regulator
EXW61_RS14775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS14785	COG1846	Transcriptional regulator
EXW61_RS14805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW61_RS14840	COG1253	flavin adenine dinucleotide binding
EXW61_RS14860	COG0028	Belongs to the TPP enzyme family
EXW61_RS14875	COG0596	Alpha beta hydrolase
EXW61_RS14885	COG1136	(ABC) transporter
EXW61_RS14895	COG3655	Transcriptional regulator
EXW61_RS14900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW61_RS14905	COG1187	pseudouridine synthase activity
EXW61_RS14915	COG2329	Antibiotic biosynthesis monooxygenase
EXW61_RS14930	COG1115	amino acid carrier protein
EXW61_RS14935	COG2318	DinB family
EXW61_RS14945	COG0776	regulation of translation
EXW61_RS14960	COG2814	Major facilitator Superfamily
EXW61_RS14965	COG3251	PFAM MbtH domain protein
EXW61_RS14970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW61_RS14975	COG3433	isochorismatase activity
EXW61_RS14975	COG1535	isochorismatase
EXW61_RS14980	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW61_RS14985	COG1169	isochorismate synthase
EXW61_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS14995	COG2223	nitrite transmembrane transporter activity
EXW61_RS15020	COG0420	3'-5' exonuclease activity
EXW61_RS15035	COG1024	Enoyl-CoA hydratase
EXW61_RS15040	COG1280	lysine exporter protein (LysE YggA)
EXW61_RS15045	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS15050	COG2084	Dehydrogenase
EXW61_RS15055	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS15060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW61_RS15065	COG2079	MmgE PrpD family protein
EXW61_RS15070	COG0372	Belongs to the citrate synthase family
EXW61_RS15080	COG2814	Major facilitator Superfamily
EXW61_RS15090	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW61_RS15090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS15135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW61_RS15225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS15230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW61_RS15235	COG0671	phosphoesterase, PA-phosphatase related
EXW61_RS15245	COG4991	sh3 domain protein
EXW61_RS15245	COG3064	Membrane
EXW61_RS15245	COG0515	serine threonine protein kinase
EXW61_RS15270	COG4479	Belongs to the UPF0346 family
EXW61_RS15280	COG1509	lysine 2,3-aminomutase activity
EXW61_RS15285	COG3829	transcription factor binding
EXW61_RS15290	COG0456	acetyltransferase
EXW61_RS15295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW61_RS15300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW61_RS15305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW61_RS15310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW61_RS15325	COG5506	Protein of unknown function (DUF1694)
EXW61_RS15330	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS15335	COG1253	flavin adenine dinucleotide binding
EXW61_RS15370	COG1174	glycine betaine transport
EXW61_RS15375	COG0517	IMP dehydrogenase activity
EXW61_RS15375	COG1125	glycine betaine transport
EXW61_RS15395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW61_RS15405	COG1070	Carbohydrate kinase
EXW61_RS15420	COG1064	alcohol dehydrogenase
EXW61_RS15425	COG1737	Transcriptional regulator
EXW61_RS15430	COG2197	response regulator
EXW61_RS15435	COG2203	Gaf domain
EXW61_RS15435	COG4585	Histidine kinase
EXW61_RS15440	COG0668	transmembrane transport
EXW61_RS15450	COG1335	isochorismatase
EXW61_RS15485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS15490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS15495	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS15510	COG0367	asparagine synthase
EXW61_RS15515	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW61_RS15520	COG1999	signal sequence binding
EXW61_RS15525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW61_RS15540	COG0805	protein transport
EXW61_RS15545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW61_RS15550	COG1272	protein, Hemolysin III
EXW61_RS15555	COG0204	Acyl-transferase
EXW61_RS15565	COG0768	penicillin binding
EXW61_RS15580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS15600	COG0546	phosphoglycolate phosphatase activity
EXW61_RS15610	COG4473	ABC transporter
EXW61_RS15615	COG1131	(ABC) transporter
EXW61_RS15620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW61_RS15625	COG0456	acetyltransferase
EXW61_RS15635	COG1794	racemase activity, acting on amino acids and derivatives
EXW61_RS15645	COG2610	gluconate transmembrane transporter activity
EXW61_RS15670	COG0733	neurotransmitter:sodium symporter activity
EXW61_RS15730	COG1674	ftsk spoiiie
EXW61_RS15750	COG0017	Asparaginyl-tRNA synthetase
EXW61_RS15785	COG2226	methyltransferase
EXW61_RS15800	COG0018	arginyl-trna synthetase
EXW61_RS15805	COG2521	methyltransferase
EXW61_RS15805	COG2136	Putative SAM-dependent methyltransferase
EXW61_RS15820	COG1413	lyase activity
EXW61_RS15840	COG0488	(ABC) transporter
EXW61_RS15925	COG2359	stage V sporulation protein S
EXW61_RS15960	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW61_RS15965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW61_RS15970	COG2146	nitrite reductase [NAD(P)H] activity
EXW61_RS15975	COG1587	Uroporphyrinogen-III synthase
EXW61_RS15975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW61_RS15985	COG1648	precorrin-2 dehydrogenase activity
EXW61_RS16005	COG2223	nitrite transmembrane transporter activity
EXW61_RS16015	COG0314	molybdopterin synthase activity
EXW61_RS16020	COG0303	'Molybdopterin
EXW61_RS16025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW61_RS16030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW61_RS16035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW61_RS16040	COG2181	nitrate reductase activity
EXW61_RS16045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW61_RS16050	COG1140	nitrate reductase beta subunit
EXW61_RS16055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW61_RS16070	COG0714	Associated with various cellular activities
EXW61_RS16075	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW61_RS16080	COG1305	Transglutaminase-like
EXW61_RS16085	COG0386	Belongs to the glutathione peroxidase family
EXW61_RS16095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW61_RS16095	COG0426	domain, Protein
EXW61_RS16120	COG1595	DNA-templated transcription, initiation
EXW61_RS16125	COG0604	alcohol dehydrogenase
EXW61_RS16155	COG2226	methyltransferase
EXW61_RS16180	COG3874	Sporulation protein YtfJ
EXW61_RS16270	COG0456	acetyltransferase
EXW61_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS16300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS16305	COG1819	glycosyl
EXW61_RS16320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW61_RS16330	COG2814	Major facilitator Superfamily
EXW61_RS16335	COG1846	Transcriptional regulator
EXW61_RS16350	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS16365	COG2211	Major facilitator Superfamily
EXW61_RS16380	COG1876	peptidase activity
EXW61_RS16390	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS16405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW61_RS16410	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS16435	COG1253	flavin adenine dinucleotide binding
EXW61_RS16440	COG2839	Protein conserved in bacteria
EXW61_RS16445	COG0702	epimerase
EXW61_RS16460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW61_RS16470	COG1607	acyl-coa hydrolase
EXW61_RS16475	COG3689	TIGRFAM TIGR03943 family protein
EXW61_RS16480	COG0701	Predicted permease
EXW61_RS16490	COG2244	polysaccharide biosynthetic process
EXW61_RS16495	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS16500	COG1051	belongs to the nudix hydrolase family
EXW61_RS16505	COG5337	Spore coat protein CotH
EXW61_RS16515	COG0406	alpha-ribazole phosphatase activity
EXW61_RS16525	COG0346	lactoylglutathione lyase activity
EXW61_RS16530	COG4166	transmembrane transport
EXW61_RS16540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW61_RS16545	COG1902	pentaerythritol trinitrate reductase activity
EXW61_RS16550	COG2205	protein histidine kinase activity
EXW61_RS16555	COG0745	RESPONSE REGULATOR receiver
EXW61_RS16565	COG1136	(ABC) transporter
EXW61_RS16590	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW61_RS16595	COG0456	acetyltransferase
EXW61_RS16600	COG0523	cobalamin synthesis protein
EXW61_RS16605	COG4989	oxidoreductase activity
EXW61_RS16610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS16615	COG1231	oxidoreductase activity
EXW61_RS16625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW61_RS16640	COG0783	Belongs to the Dps family
EXW61_RS16645	COG3949	Membrane
EXW61_RS16685	COG2814	Major facilitator Superfamily
EXW61_RS16695	COG0640	Transcriptional regulator
EXW61_RS16700	COG1404	Belongs to the peptidase S8 family
EXW61_RS16705	COG2002	toxin-antitoxin pair type II binding
EXW61_RS16710	COG0577	efflux transmembrane transporter activity
EXW61_RS16715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW61_RS16745	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW61_RS16755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS16760	COG1279	arginine transmembrane transporter activity
EXW61_RS16765	COG2814	Major facilitator Superfamily
EXW61_RS16775	COG1082	Xylose isomerase domain protein TIM barrel
EXW61_RS16785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW61_RS16805	COG1247	-acetyltransferase
EXW61_RS16810	COG1285	pathogenesis
EXW61_RS16825	COG1316	TRANSCRIPTIONal
EXW61_RS16840	COG0083	homoserine kinase activity
EXW61_RS16850	COG0460	homoserine dehydrogenase
EXW61_RS16860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EXW61_RS16880	COG4122	O-methyltransferase activity
EXW61_RS16885	COG0300	oxidoreductase activity
EXW61_RS16890	COG5002	protein histidine kinase activity
EXW61_RS16895	COG0745	RESPONSE REGULATOR receiver
EXW61_RS16900	COG1132	(ABC) transporter
EXW61_RS16910	COG0791	NLP P60 protein
EXW61_RS16910	COG1388	LysM domain
EXW61_RS16925	COG1686	Belongs to the peptidase S11 family
EXW61_RS16955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW61_RS16960	COG4988	ABC transporter
EXW61_RS16965	COG1294	oxidase, subunit
EXW61_RS16970	COG1271	oxidase subunit
EXW61_RS16980	COG0346	lactoylglutathione lyase activity
EXW61_RS16995	COG1942	4-Oxalocrotonate Tautomerase
EXW61_RS17005	COG0583	DNA-binding transcription factor activity
EXW61_RS17025	COG0411	ABC transporter
EXW61_RS17035	COG0523	cobalamin synthesis protein
EXW61_RS17040	COG1231	oxidoreductase activity
EXW61_RS17055	COG0628	permease
EXW61_RS17070	COG0778	Nitroreductase
EXW61_RS17075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW61_RS17080	COG1959	2 iron, 2 sulfur cluster binding
EXW61_RS17085	COG0583	DNA-binding transcription factor activity
EXW61_RS17090	COG0697	spore germination
EXW61_RS17100	COG4549	nuclear export factor GLE1
EXW61_RS17105	COG1276	copper resistance
EXW61_RS17105	COG2372	response to copper ion
EXW61_RS17150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS17160	COG1834	amidinotransferase
EXW61_RS17170	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS17190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW61_RS17200	COG2132	Multicopper oxidase
EXW61_RS17205	COG0006	proline dipeptidase activity
EXW61_RS17220	COG0583	DNA-binding transcription factor activity
EXW61_RS17235	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW61_RS17250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW61_RS17255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS17260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW61_RS17270	COG2390	Transcriptional regulator
EXW61_RS17275	COG4257	antibiotic catabolic process
EXW61_RS17290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW61_RS17325	COG0531	amino acid
EXW61_RS17330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW61_RS17340	COG1054	Belongs to the UPF0176 family
EXW61_RS17345	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW61_RS17365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW61_RS17385	COG4166	transmembrane transport
EXW61_RS17430	COG3384	dioxygenase
EXW61_RS17435	COG2814	Major facilitator Superfamily
EXW61_RS17455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW61_RS17475	COG0028	Belongs to the TPP enzyme family
EXW61_RS17480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS17490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW61_RS17515	COG2323	membrane
EXW61_RS17520	COG5566	PFAM Mor transcription activator
EXW61_RS17530	COG0733	neurotransmitter:sodium symporter activity
EXW61_RS17535	COG2244	polysaccharide biosynthetic process
EXW61_RS17545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW61_RS17550	COG2223	nitrite transmembrane transporter activity
EXW61_RS17555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW61_RS17575	COG0477	Major facilitator Superfamily
EXW61_RS17605	COG2814	Major facilitator Superfamily
EXW61_RS17650	COG2502	aspartate--ammonia ligase
EXW61_RS17660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW61_RS17670	COG1846	Transcriptional regulator
EXW61_RS17675	COG0784	Response regulator, receiver
EXW61_RS17680	COG4191	Histidine kinase
EXW61_RS17685	COG0281	malic enzyme
EXW61_RS17690	COG1027	Aspartate ammonia-lyase
EXW61_RS17700	COG0528	UMP kinase activity
EXW61_RS17705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW61_RS17720	COG1131	(ABC) transporter
EXW61_RS17755	COG2733	membrane
EXW61_RS17760	COG3048	D-serine ammonia-lyase activity
EXW61_RS17775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS17780	COG0785	Cytochrome C biogenesis protein
EXW61_RS17800	COG3340	Belongs to the peptidase S51 family
EXW61_RS17805	COG0534	Mate efflux family protein
EXW61_RS17830	COG1757	Na H antiporter
EXW61_RS17835	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS17835	COG1216	Glycosyl transferase, family 2
EXW61_RS17840	COG0697	spore germination
EXW61_RS17845	COG1802	Transcriptional regulator
EXW61_RS17875	COG0367	asparagine synthase
EXW61_RS17905	COG0406	alpha-ribazole phosphatase activity
EXW61_RS17955	COG3842	ATPase activity
EXW61_RS17960	COG0583	DNA-binding transcription factor activity
EXW61_RS17970	COG2814	Major facilitator Superfamily
EXW61_RS17985	COG2329	Antibiotic biosynthesis monooxygenase
EXW61_RS17990	COG0412	Dienelactone hydrolase
EXW61_RS18020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW61_RS18025	COG4786	Flagellar basal body rod
EXW61_RS18030	COG1419	protein localization to endoplasmic reticulum
EXW61_RS18035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW61_RS18040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW61_RS18050	COG1987	bacterial-type flagellum assembly
EXW61_RS18055	COG1338	Plays a role in the flagellum-specific transport system
EXW61_RS18065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW61_RS18065	COG1776	CheC inhibitor of MCP methylation
EXW61_RS18070	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW61_RS18080	COG0741	lytic transglycosylase activity
EXW61_RS18085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW61_RS18090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW61_RS18095	COG0489	protein tyrosine kinase activity
EXW61_RS18105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW61_RS18110	COG0314	molybdopterin synthase activity
EXW61_RS18115	COG0303	'Molybdopterin
EXW61_RS18120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW61_RS18125	COG2116	formate transmembrane transporter activity
EXW61_RS18135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW61_RS18140	COG5609	conserved protein (DUF2294)
EXW61_RS18145	COG2427	Protein of unknown function (DUF1641)
EXW61_RS18150	COG3383	formate dehydrogenase (NAD+) activity
EXW61_RS18160	COG0861	Integral membrane protein TerC family
EXW61_RS18180	COG0835	chemotaxis
EXW61_RS18180	COG0784	Response regulator, receiver
EXW61_RS18195	COG1749	Flagellar hook protein flgE
EXW61_RS18215	COG1157	protein secretion by the type III secretion system
EXW61_RS18225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW61_RS18230	COG1766	The M ring may be actively involved in energy transduction
EXW61_RS18240	COG1558	bacterial-type flagellum-dependent cell motility
EXW61_RS18245	COG1815	bacterial-type flagellum-dependent cell motility
EXW61_RS18265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW61_RS18270	COG1256	bacterial-type flagellum assembly
EXW61_RS18290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW61_RS18305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW61_RS18305	COG1776	CheC inhibitor of MCP methylation
EXW61_RS18310	COG2198	Histidine kinase
EXW61_RS18310	COG0643	Histidine kinase
EXW61_RS18315	COG2201	protein-glutamate methylesterase activity
EXW61_RS18320	COG1360	Flagellar Motor Protein
EXW61_RS18325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW61_RS18335	COG1923	regulation of RNA biosynthetic process
EXW61_RS18355	COG2814	Major facilitator Superfamily
EXW61_RS18380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW61_RS18385	COG2323	membrane
EXW61_RS18395	COG4978	Transcriptional regulator
EXW61_RS18395	COG0789	Transcriptional regulator
EXW61_RS18400	COG0475	glutathione-regulated potassium exporter activity
EXW61_RS18410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW61_RS18415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW61_RS18420	COG3162	membrane
EXW61_RS18435	COG1280	lysine exporter protein (LysE YggA)
EXW61_RS18440	COG3403	YqcI/YcgG family
EXW61_RS18475	COG0328	RNA-DNA hybrid ribonuclease activity
EXW61_RS18495	COG0454	-acetyltransferase
EXW61_RS18510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW61_RS18550	COG2897	thiosulfate sulfurtransferase activity
EXW61_RS18560	COG0456	acetyltransferase
EXW61_RS18570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW61_RS18575	COG2311	Membrane
EXW61_RS18580	COG2233	PERMEase
EXW61_RS18585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW61_RS18590	COG0024	Methionine aminopeptidase
EXW61_RS18600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW61_RS18605	COG1199	ATP-dependent helicase activity
EXW61_RS18615	COG0116	Belongs to the methyltransferase superfamily
EXW61_RS18625	COG3599	regulation of cell shape
EXW61_RS18630	COG4474	Belongs to the UPF0398 family
EXW61_RS18665	COG3331	DNA recombination
EXW61_RS18670	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW61_RS18670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS18680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW61_RS18685	COG3935	DnaD domain protein
EXW61_RS18705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW61_RS18705	COG1199	ATP-dependent helicase activity
EXW61_RS18715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW61_RS18720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW61_RS18730	COG0617	tRNA 3'-terminal CCA addition
EXW61_RS18735	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS18740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW61_RS18745	COG1803	Methylglyoxal synthase
EXW61_RS18750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW61_RS18755	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW61_RS18760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS18770	COG2738	Putative neutral zinc metallopeptidase
EXW61_RS18785	COG4347	Protein of unknown function (DUF1405)
EXW61_RS18800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW61_RS18815	COG5582	Belongs to the UPF0302 family
EXW61_RS18820	COG0457	Tetratricopeptide repeat
EXW61_RS18825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW61_RS18835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW61_RS18850	COG0142	geranyltranstransferase activity
EXW61_RS18855	COG2226	methyltransferase
EXW61_RS18860	COG0142	geranyltranstransferase activity
EXW61_RS18865	COG0302	gtp cyclohydrolase
EXW61_RS18875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW61_RS18895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW61_RS18900	COG1160	GTP binding
EXW61_RS18930	COG1304	FMN binding
EXW61_RS18940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW61_RS18950	COG0252	asparaginase activity
EXW61_RS18955	COG0492	ferredoxin-NADP+ reductase activity
EXW61_RS18975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW61_RS18990	COG1408	metallophosphoesterase
EXW61_RS19000	COG1266	CAAX protease self-immunity
EXW61_RS19005	COG0514	ATP-dependent DNA helicase (RecQ)
EXW61_RS19010	COG4955	Helix-turn-helix domain
EXW61_RS19015	COG1141	Ferredoxin
EXW61_RS19020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW61_RS19030	COG4942	peptidase
EXW61_RS19035	COG2096	Adenosyltransferase
EXW61_RS19040	COG5002	protein histidine kinase activity
EXW61_RS19045	COG0745	RESPONSE REGULATOR receiver
EXW61_RS19050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW61_RS19055	COG1333	cytochrome c biogenesis protein
EXW61_RS19065	COG1187	pseudouridine synthase activity
EXW61_RS19070	COG0700	Nucleoside recognition
EXW61_RS19075	COG2715	membrane protein required for spore maturation
EXW61_RS19080	COG1686	Belongs to the peptidase S11 family
EXW61_RS19085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW61_RS19100	COG0392	lysyltransferase activity
EXW61_RS19100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW61_RS19115	COG5002	protein histidine kinase activity
EXW61_RS19120	COG0582	viral genome integration into host DNA
EXW61_RS19130	COG1801	Protein of unknown function DUF72
EXW61_RS19135	COG3852	Histidine kinase
EXW61_RS19150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS19155	COG1392	Phosphate transport regulator
EXW61_RS19160	COG0306	phosphate transporter
EXW61_RS19165	COG0730	response to heat
EXW61_RS19205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW61_RS19215	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS19225	COG2197	response regulator
EXW61_RS19230	COG4585	Histidine kinase
EXW61_RS19235	COG4758	membrane
EXW61_RS19255	COG1757	Na H antiporter
EXW61_RS19280	COG0733	neurotransmitter:sodium symporter activity
EXW61_RS19285	COG1648	precorrin-2 dehydrogenase activity
EXW61_RS19305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW61_RS19310	COG0529	Catalyzes the synthesis of activated sulfate
EXW61_RS19315	COG2046	Belongs to the sulfate adenylyltransferase family
EXW61_RS19320	COG0175	sulfate reduction
EXW61_RS19330	COG0019	diaminopimelate decarboxylase activity
EXW61_RS19340	COG1368	sulfuric ester hydrolase activity
EXW61_RS19345	COG1183	phosphatidylcholine synthase activity
EXW61_RS19360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW61_RS19365	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW61_RS19375	COG0107	imidazoleglycerol-phosphate synthase activity
EXW61_RS19380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW61_RS19385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW61_RS19390	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW61_RS19400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW61_RS19405	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW61_RS19415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW61_RS19425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW61_RS19435	COG0440	acetolactate synthase activity
EXW61_RS19440	COG0028	Belongs to the TPP enzyme family
EXW61_RS19445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS19470	COG3874	Sporulation protein YtfJ
EXW61_RS19480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW61_RS19485	COG1301	dicarboxylic acid transport
EXW61_RS19495	COG1846	Transcriptional regulator
EXW61_RS19555	COG0716	FMN binding
EXW61_RS19575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW61_RS19580	COG1696	Membrane protein involved in D-alanine export
EXW61_RS19585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW61_RS19590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW61_RS19595	COG2070	2-Nitropropane dioxygenase
EXW61_RS19600	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW61_RS19610	COG1335	isochorismatase
EXW61_RS19620	COG1522	sequence-specific DNA binding
EXW61_RS19640	COG1131	(ABC) transporter
EXW61_RS19650	COG1131	(ABC) transporter
EXW61_RS19655	COG1725	Transcriptional regulator
EXW61_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS19670	COG3290	protein histidine kinase activity
EXW61_RS19670	COG3829	transcription factor binding
EXW61_RS19680	COG0531	amino acid
EXW61_RS19685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW61_RS19700	COG1780	Probably involved in ribonucleotide reductase function
EXW61_RS19715	COG0456	acetyltransferase
EXW61_RS19730	COG4873	Protein conserved in bacteria
EXW61_RS19735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW61_RS19745	COG0720	synthase
EXW61_RS19750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW61_RS19755	COG5002	protein histidine kinase activity
EXW61_RS19760	COG2318	DinB family
EXW61_RS19770	COG1846	Transcriptional regulator
EXW61_RS19775	COG3852	Histidine kinase
EXW61_RS19785	COG2861	carbohydrate metabolic process
EXW61_RS19795	COG0235	Class ii aldolase
EXW61_RS19805	COG1349	DNA-binding transcription factor activity
EXW61_RS19815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW61_RS19820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW61_RS19830	COG3842	ATPase activity
EXW61_RS19835	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW61_RS19850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW61_RS19860	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW61_RS19865	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS19885	COG2030	dehydratase
EXW61_RS19895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW61_RS19900	COG0861	Integral membrane protein TerC family
EXW61_RS19905	COG2116	formate transmembrane transporter activity
EXW61_RS19915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW61_RS19920	COG1556	Lactate utilization protein
EXW61_RS19925	COG1139	Iron-sulfur cluster binding protein
EXW61_RS19930	COG0247	lactate metabolic process
EXW61_RS19935	COG2186	Transcriptional regulator
EXW61_RS19940	COG5002	protein histidine kinase activity
EXW61_RS19945	COG0745	RESPONSE REGULATOR receiver
EXW61_RS19955	COG3835	regulator
EXW61_RS19960	COG0277	FAD linked oxidase domain protein
EXW61_RS19965	COG0247	lactate metabolic process
EXW61_RS19970	COG2340	Cysteine-rich secretory protein family
EXW61_RS19980	COG0564	pseudouridine synthase activity
EXW61_RS19990	COG2409	Drug exporters of the RND superfamily
EXW61_RS20000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW61_RS20005	COG1177	transmembrane transport
EXW61_RS20010	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW61_RS20020	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS20055	COG0681	Belongs to the peptidase S26 family
EXW61_RS20060	COG1686	Belongs to the peptidase S11 family
EXW61_RS20140	COG3646	Phage regulatory protein
EXW61_RS20140	COG3645	SOS response
EXW61_RS20155	COG1668	transmembrane transport
EXW61_RS20160	COG4152	abc transporter atp-binding protein
EXW61_RS20180	COG1476	TRANSCRIPTIONal
EXW61_RS20185	COG0567	Dehydrogenase, E1 component
EXW61_RS20190	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW61_RS20210	COG2226	methyltransferase
EXW61_RS20260	COG5634	Uncharacterized conserved protein (DUF2278)
EXW61_RS20265	COG1620	l-lactate permease
EXW61_RS20275	COG0159	tryptophan synthase activity
EXW61_RS20280	COG0133	tryptophan synthase activity
EXW61_RS20285	COG0135	phosphoribosylanthranilate isomerase activity
EXW61_RS20290	COG0134	indole-3-glycerol-phosphate synthase activity
EXW61_RS20295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW61_RS20300	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW61_RS20300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW61_RS20310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW61_RS20315	COG5492	domain, Protein
EXW61_RS20340	COG2382	esterase
EXW61_RS20345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW61_RS20350	COG2153	protein acetylation
EXW61_RS20395	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW61_RS20410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW61_RS20430	COG0457	Tetratricopeptide repeat
EXW61_RS20430	COG0463	Glycosyl transferase, family 2
EXW61_RS20450	COG1216	Glycosyl transferase, family 2
EXW61_RS20455	COG0772	Belongs to the SEDS family
EXW61_RS20460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW61_RS20470	COG0564	pseudouridine synthase activity
EXW61_RS20480	COG2357	RelA SpoT domain protein
EXW61_RS20490	COG4116	CYTH
EXW61_RS20495	COG2346	COG2346, Truncated hemoglobins
EXW61_RS20510	COG1164	Oligoendopeptidase f
EXW61_RS20520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW61_RS20525	COG4862	establishment of competence for transformation
EXW61_RS20530	COG0861	Integral membrane protein TerC family
EXW61_RS20545	COG4166	transmembrane transport
EXW61_RS20550	COG0534	Mate efflux family protein
EXW61_RS20555	COG4608	Belongs to the ABC transporter superfamily
EXW61_RS20560	COG0444	Belongs to the ABC transporter superfamily
EXW61_RS20565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW61_RS20570	COG0601	transmembrane transport
EXW61_RS20575	COG4166	transmembrane transport
EXW61_RS20585	COG0180	Tryptophanyl-tRNA synthetase
EXW61_RS20595	COG5504	Zn-dependent protease
EXW61_RS20600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW61_RS20605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW61_RS20620	COG2267	carboxylic ester hydrolase activity
EXW61_RS20640	COG0561	phosphatase activity
EXW61_RS20655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS20665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW61_RS20695	COG1329	Transcriptional regulator
EXW61_RS20710	COG2996	Protein conserved in bacteria
EXW61_RS20715	COG1666	GTP binding
EXW61_RS20725	COG0004	ammonium transporteR
EXW61_RS20730	COG0753	catalase activity
EXW61_RS20740	COG0367	asparagine synthase
EXW61_RS20765	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW61_RS20815	COG1074	ATP-dependent DNA helicase activity
EXW61_RS20820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW61_RS20830	COG0398	Pfam SNARE associated Golgi protein
EXW61_RS20835	COG4903	ComK protein
EXW61_RS20850	COG1278	Cold shock
EXW61_RS20860	COG2224	Isocitrate lyase
EXW61_RS20865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW61_RS20870	COG3693	PFAM glycoside hydrolase, family 10
EXW61_RS20875	COG0697	spore germination
EXW61_RS20880	COG0840	transmembrane signaling receptor activity
EXW61_RS20885	COG0501	Belongs to the peptidase M48B family
EXW61_RS20905	COG0745	RESPONSE REGULATOR receiver
EXW61_RS20910	COG2205	protein histidine kinase activity
EXW61_RS20915	COG3708	Transcriptional regulator
EXW61_RS20915	COG2207	Transcriptional regulator
EXW61_RS20920	COG1595	DNA-templated transcription, initiation
EXW61_RS20935	COG1078	dGTPase activity
EXW61_RS20940	COG1408	metallophosphoesterase
EXW61_RS20965	COG3209	COG3209 Rhs family protein
EXW61_RS20975	COG4208	sulfate ABC transporter
EXW61_RS20985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW61_RS20995	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS21005	COG0095	Lipoate-protein ligase
EXW61_RS21010	COG1234	tRNA 3'-trailer cleavage
EXW61_RS21020	COG1609	Transcriptional regulator
EXW61_RS21025	COG2378	regulation of single-species biofilm formation
EXW61_RS21060	COG1511	domain protein
EXW61_RS21065	COG1309	transcriptional regulator
EXW61_RS21090	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW61_RS21095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW61_RS21100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW61_RS21105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS21110	COG2329	Antibiotic biosynthesis monooxygenase
EXW61_RS21115	COG3428	Bacterial PH domain
EXW61_RS21120	COG3402	PFAM membrane-flanked domain
EXW61_RS21160	COG3428	Bacterial PH domain
EXW61_RS21165	COG3402	PFAM membrane-flanked domain
EXW61_RS21185	COG1556	Lactate utilization protein
EXW61_RS21190	COG1139	Iron-sulfur cluster binding protein
EXW61_RS21195	COG0247	lactate metabolic process
EXW61_RS21205	COG4473	ABC transporter
EXW61_RS21210	COG1131	(ABC) transporter
EXW61_RS21215	COG0537	adenosine 5'-monophosphoramidase activity
EXW61_RS21240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW61_RS21245	COG3973	AAA domain
EXW61_RS21260	COG1595	DNA-templated transcription, initiation
EXW61_RS21265	COG0693	protein deglycase activity
EXW61_RS21285	COG1695	Transcriptional regulator
EXW61_RS21290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW61_RS21295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW61_RS21300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW61_RS21305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW61_RS21310	COG3620	sequence-specific DNA binding
EXW61_RS21320	COG2267	carboxylic ester hydrolase activity
EXW61_RS21330	COG0457	Tetratricopeptide repeat
EXW61_RS21335	COG0346	lactoylglutathione lyase activity
EXW61_RS21340	COG0346	lactoylglutathione lyase activity
EXW61_RS21350	COG5444	nuclease activity
EXW61_RS21390	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW61_RS21395	COG4717	serine-type aminopeptidase activity
EXW61_RS21400	COG0420	3'-5' exonuclease activity
EXW61_RS21430	COG2197	response regulator
EXW61_RS21440	COG2186	Transcriptional regulator
EXW61_RS21445	COG2807	transmembrane transport
EXW61_RS21490	COG2198	Histidine kinase
EXW61_RS21490	COG2205	protein histidine kinase activity
EXW61_RS21490	COG0784	Response regulator, receiver
EXW61_RS21495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW61_RS21500	COG2208	phosphoserine phosphatase activity
EXW61_RS21510	COG1191	sigma factor activity
EXW61_RS21515	COG2172	sigma factor antagonist activity
EXW61_RS21535	COG3237	CsbD-like
EXW61_RS21560	COG2409	Drug exporters of the RND superfamily
EXW61_RS21570	COG1278	Cold shock
EXW61_RS21575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW61_RS21600	COG0076	glutamate decarboxylase activity
EXW61_RS21625	COG2720	vancomycin resistance protein
EXW61_RS21640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW61_RS21655	COG2376	Dihydroxyacetone kinase
EXW61_RS21665	COG2376	Dihydroxyacetone kinase
EXW61_RS21685	COG0640	Transcriptional regulator
EXW61_RS21690	COG2814	Major facilitator Superfamily
EXW61_RS21750	COG1183	phosphatidylcholine synthase activity
EXW61_RS21760	COG0456	acetyltransferase
EXW61_RS21765	COG2723	6-phospho-beta-galactosidase activity
EXW61_RS21770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS21770	COG1263	PTS System
EXW61_RS21770	COG2190	(PTS) system
EXW61_RS21775	COG3711	transcriptional antiterminator
EXW61_RS21810	COG0477	Major facilitator Superfamily
EXW61_RS21840	COG0305	Participates in initiation and elongation during chromosome replication
EXW61_RS21855	COG0789	Transcriptional regulator
EXW61_RS21900	COG3181	Tripartite tricarboxylate transporter family receptor
EXW61_RS21905	COG4565	transcriptional regulatory protein
EXW61_RS21910	COG3290	protein histidine kinase activity
EXW61_RS21915	COG0477	Major facilitator Superfamily
EXW61_RS21960	COG4608	Belongs to the ABC transporter superfamily
EXW61_RS21965	COG0444	Belongs to the ABC transporter superfamily
EXW61_RS21970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW61_RS21975	COG0601	transmembrane transport
EXW61_RS22005	COG0579	oxidoreductase
EXW61_RS22025	COG2318	DinB family
EXW61_RS22040	COG1363	Peptidase, m42
EXW61_RS22060	COG1024	Enoyl-CoA hydratase
EXW61_RS22080	COG2244	polysaccharide biosynthetic process
EXW61_RS22085	COG0659	secondary active sulfate transmembrane transporter activity
EXW61_RS22095	COG0318	PFAM AMP-dependent synthetase and ligase
EXW61_RS22100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW61_RS22105	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS22105	COG3409	Peptidoglycan-binding domain 1 protein
EXW61_RS22115	COG0561	phosphatase activity
EXW61_RS22120	COG2094	Belongs to the DNA glycosylase MPG family
EXW61_RS22125	COG1216	Glycosyl transferase, family 2
EXW61_RS22130	COG0463	Glycosyl transferase, family 2
EXW61_RS22135	COG3527	Alpha-acetolactate decarboxylase
EXW61_RS22140	COG0028	Belongs to the TPP enzyme family
EXW61_RS22155	COG3679	Belongs to the UPF0342 family
EXW61_RS22160	COG4399	Belongs to the UPF0754 family
EXW61_RS22170	COG0189	ligase activity
EXW61_RS22185	COG1126	abc transporter atp-binding protein
EXW61_RS22190	COG0765	amino acid transport
EXW61_RS22195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS22200	COG1132	(ABC) transporter
EXW61_RS22205	COG1132	(ABC) transporter
EXW61_RS22210	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS22215	COG0531	amino acid
EXW61_RS22225	COG0693	protein deglycase activity
EXW61_RS22235	COG2211	Major facilitator Superfamily
EXW61_RS22240	COG4533	DNA binding
EXW61_RS22255	COG1733	regulation of RNA biosynthetic process
EXW61_RS22260	COG2814	Major facilitator Superfamily
EXW61_RS22265	COG1309	transcriptional regulator
EXW61_RS22270	COG2076	Multidrug Resistance protein
EXW61_RS22285	COG0300	oxidoreductase activity
EXW61_RS22295	COG1522	sequence-specific DNA binding
EXW61_RS22300	COG0697	spore germination
EXW61_RS22320	COG2259	Doxx family
EXW61_RS22330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS22330	COG1263	PTS System
EXW61_RS22340	COG1737	Transcriptional regulator
EXW61_RS22350	COG0475	glutathione-regulated potassium exporter activity
EXW61_RS22355	COG0531	amino acid
EXW61_RS22385	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS22415	COG3546	catalase activity
EXW61_RS22420	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS22435	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW61_RS22445	COG1136	(ABC) transporter
EXW61_RS22450	COG0577	efflux transmembrane transporter activity
EXW61_RS22455	COG3583	domain protein
EXW61_RS22455	COG3584	3D domain protein
EXW61_RS22460	COG1388	LysM domain
EXW61_RS22460	COG0791	NLP P60 protein
EXW61_RS22470	COG4824	toxin secretion phage lysis holin
EXW61_RS22480	COG1396	sequence-specific DNA binding
EXW61_RS22485	COG3584	3D domain protein
EXW61_RS22485	COG1388	LysM domain
EXW61_RS22505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW61_RS22510	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW61_RS22515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW61_RS22515	COG3711	transcriptional antiterminator
EXW61_RS22530	COG0604	alcohol dehydrogenase
EXW61_RS22535	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW61_RS22555	COG1316	TRANSCRIPTIONal
EXW61_RS22565	COG0730	response to heat
EXW61_RS22570	COG2210	Belongs to the sulfur carrier protein TusA family
EXW61_RS22575	COG0425	Belongs to the sulfur carrier protein TusA family
EXW61_RS22575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS22580	COG0425	Belongs to the sulfur carrier protein TusA family
EXW61_RS22585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS22585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS22590	COG0425	Belongs to the sulfur carrier protein TusA family
EXW61_RS22590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW61_RS22595	COG1937	Protein conserved in bacteria
EXW61_RS22620	COG2719	SpoVR family
EXW61_RS22625	COG0778	Nitroreductase
EXW61_RS22685	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS22690	COG2252	PERMEase
EXW61_RS22695	COG1879	ABC-type sugar transport system periplasmic component
EXW61_RS22700	COG1129	ABC transporter
EXW61_RS22705	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW61_RS22725	COG1846	Transcriptional regulator
EXW61_RS22730	COG2814	Major facilitator Superfamily
EXW61_RS22735	COG2205	protein histidine kinase activity
EXW61_RS22740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW61_RS22745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW61_RS22750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW61_RS22775	COG0351	phosphomethylpyrimidine kinase
EXW61_RS22780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW61_RS22785	COG2022	thiamine diphosphate biosynthetic process
EXW61_RS22790	COG2104	thiamine diphosphate biosynthetic process
EXW61_RS22795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW61_RS22800	COG0352	thiamine-phosphate diphosphorylase activity
EXW61_RS22805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW61_RS22810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW61_RS22815	COG1116	anion transmembrane transporter activity
EXW61_RS22820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW61_RS22825	COG3103	Sh3 type 3 domain protein
EXW61_RS22825	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS22825	COG4991	sh3 domain protein
EXW61_RS22840	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW61_RS22960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW61_RS22965	COG0581	inorganic phosphate transmembrane transporter activity
EXW61_RS22970	COG0573	inorganic phosphate transmembrane transporter activity
EXW61_RS22975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW61_RS22985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW61_RS22990	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW61_RS23000	COG0531	amino acid
EXW61_RS23005	COG0697	spore germination
EXW61_RS23010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW61_RS23025	COG4990	cell redox homeostasis
EXW61_RS23030	COG0833	amino acid
EXW61_RS23040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW61_RS23045	COG1845	cytochrome c oxidase, subunit III
EXW61_RS23055	COG0569	domain protein
EXW61_RS23055	COG0475	glutathione-regulated potassium exporter activity
EXW61_RS23075	COG3620	sequence-specific DNA binding
EXW61_RS23080	COG2252	PERMEase
EXW61_RS23085	COG1113	amino acid transport
EXW61_RS23100	COG1114	Component of the transport system for branched-chain amino acids
EXW61_RS23105	COG3104	oligopeptide transport
EXW61_RS23125	COG1476	TRANSCRIPTIONal
EXW61_RS23130	COG1388	LysM domain
EXW61_RS23130	COG3584	3D domain protein
EXW61_RS23135	COG0840	transmembrane signaling receptor activity
EXW61_RS23180	COG1063	alcohol dehydrogenase
EXW61_RS23210	COG1879	ABC-type sugar transport system periplasmic component
EXW61_RS23215	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW61_RS23225	COG1869	D-ribose catabolic process
EXW61_RS23230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW61_RS23235	COG1609	Transcriptional regulator
EXW61_RS23240	COG0477	Major facilitator Superfamily
EXW61_RS23245	COG1846	Transcriptional regulator
EXW61_RS23250	COG2271	Major facilitator Superfamily
EXW61_RS23260	COG4608	Belongs to the ABC transporter superfamily
EXW61_RS23265	COG0601	transmembrane transport
EXW61_RS23275	COG0747	negative chemotaxis
EXW61_RS23290	COG0659	secondary active sulfate transmembrane transporter activity
EXW61_RS23305	COG5002	protein histidine kinase activity
EXW61_RS23310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW61_RS23315	COG2378	regulation of single-species biofilm formation
EXW61_RS23335	COG0833	amino acid
EXW61_RS23340	COG0765	amino acid transport
EXW61_RS23345	COG0765	amino acid transport
EXW61_RS23350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS23355	COG1126	abc transporter atp-binding protein
EXW61_RS23360	COG1115	amino acid carrier protein
EXW61_RS23365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW61_RS23380	COG1404	Belongs to the peptidase S8 family
EXW61_RS23385	COG2197	response regulator
EXW61_RS23390	COG4585	Histidine kinase
EXW61_RS23395	COG0697	spore germination
EXW61_RS23410	COG0366	Alpha amylase catalytic
EXW61_RS23415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS23415	COG1263	PTS System
EXW61_RS23420	COG2188	Transcriptional regulator
EXW61_RS23425	COG0531	amino acid
EXW61_RS23445	COG0714	Associated with various cellular activities
EXW61_RS23450	COG4548	von Willebrand factor, type A
EXW61_RS23460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW61_RS23465	COG0156	8-amino-7-oxononanoate synthase activity
EXW61_RS23480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS23485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS23490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS23495	COG3104	oligopeptide transport
EXW61_RS23510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW61_RS23515	COG1620	l-lactate permease
EXW61_RS23520	COG1027	Aspartate ammonia-lyase
EXW61_RS23525	COG1253	flavin adenine dinucleotide binding
EXW61_RS23530	COG0346	lactoylglutathione lyase activity
EXW61_RS23535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS23540	COG1316	TRANSCRIPTIONal
EXW61_RS23545	COG2720	vancomycin resistance protein
EXW61_RS23565	COG3227	Zinc metalloprotease (Elastase)
EXW61_RS23580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW61_RS23585	COG2217	Heavy metal translocating P-type atpase
EXW61_RS23590	COG0640	Transcriptional regulator
EXW61_RS23600	COG0531	amino acid
EXW61_RS23615	COG2427	Protein of unknown function (DUF1641)
EXW61_RS23620	COG3383	formate dehydrogenase (NAD+) activity
EXW61_RS23625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW61_RS23630	COG0456	acetyltransferase
EXW61_RS23635	COG0745	RESPONSE REGULATOR receiver
EXW61_RS23640	COG5002	protein histidine kinase activity
EXW61_RS23650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW61_RS23655	COG0697	spore germination
EXW61_RS23665	COG0281	malic enzyme
EXW61_RS23670	COG3493	citrate carrier protein
EXW61_RS23675	COG4565	transcriptional regulatory protein
EXW61_RS23680	COG3290	protein histidine kinase activity
EXW61_RS23690	COG4990	cell redox homeostasis
EXW61_RS23700	COG5002	protein histidine kinase activity
EXW61_RS23705	COG0745	RESPONSE REGULATOR receiver
EXW61_RS23710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW61_RS23720	COG0395	ABC-type sugar transport system, permease component
EXW61_RS23725	COG1175	transmembrane transport
EXW61_RS23730	COG3842	ATPase activity
EXW61_RS23735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW61_RS23760	COG2851	Citrate transporter
EXW61_RS23765	COG4565	transcriptional regulatory protein
EXW61_RS23770	COG3290	protein histidine kinase activity
EXW61_RS23780	COG2268	Band 7 protein
EXW61_RS23785	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW61_RS23850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXW61_RS23870	COG2718	Belongs to the UPF0229 family
EXW61_RS23875	COG2766	serine protein kinase
EXW61_RS23880	COG1716	ATPase activity
EXW61_RS23880	COG5001	Diguanylate cyclase
EXW61_RS23885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW61_RS23905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW61_RS23910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW61_RS24025	COG0735	belongs to the Fur family
EXW61_RS24030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW61_RS24050	COG4555	ABC transporter
EXW61_RS24055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW61_RS24060	COG0067	glutamate synthase
EXW61_RS24060	COG0069	glutamate synthase activity
EXW61_RS24060	COG0070	glutamate synthase
EXW61_RS24065	COG4129	membrane
EXW61_RS24070	COG1132	(ABC) transporter
EXW61_RS24075	COG3557	Belongs to the UPF0374 family
EXW61_RS24100	COG1194	a g-specific adenine glycosylase
EXW61_RS24105	COG1988	membrane-bound metal-dependent
EXW61_RS24130	COG2137	regulation of response to DNA damage stimulus
EXW61_RS24135	COG1090	epimerase
EXW61_RS24140	COG1228	amidohydrolase
EXW61_RS24155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW61_RS24160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW61_RS24175	COG0463	Glycosyl transferase, family 2
EXW61_RS24180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW61_RS24180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW61_RS24190	COG1216	Glycosyl transferase, family 2
EXW61_RS24210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS24215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS24215	COG1263	PTS System
EXW61_RS24220	COG2066	Belongs to the glutaminase family
EXW61_RS24240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW61_RS24245	COG0833	amino acid
EXW61_RS24255	COG3829	transcription factor binding
EXW61_RS24275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW61_RS24300	COG0535	radical SAM domain protein
EXW61_RS24310	COG0387	Pfam Sodium calcium exchanger
EXW61_RS24315	COG3871	stress protein (general stress protein 26)
EXW61_RS24330	COG0586	Pfam SNARE associated Golgi protein
EXW61_RS24350	COG0697	spore germination
EXW61_RS24355	COG2217	Heavy metal translocating P-type atpase
EXW61_RS24360	COG1295	ribonuclease BN
EXW61_RS24370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW61_RS24375	COG4840	Belongs to the UPF0435 family
EXW61_RS24385	COG3853	Toxic anion resistance protein (TelA)
EXW61_RS24395	COG0861	Integral membrane protein TerC family
EXW61_RS24400	COG2310	stress, protein
EXW61_RS24405	COG2310	stress, protein
EXW61_RS24410	COG2310	stress, protein
EXW61_RS24440	COG2270	Major facilitator Superfamily
EXW61_RS24485	COG0488	(ABC) transporter
EXW61_RS24490	COG1116	anion transmembrane transporter activity
EXW61_RS24495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW61_RS24500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW61_RS24515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW61_RS24520	COG0352	thiamine-phosphate diphosphorylase activity
EXW61_RS24525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW61_RS24545	COG1263	PTS System
EXW61_RS24545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW61_RS24545	COG2190	(PTS) system
EXW61_RS24550	COG0366	Alpha amylase catalytic
EXW61_RS24555	COG0277	FAD linked oxidase domain protein
EXW61_RS24570	COG0549	Belongs to the carbamate kinase family
EXW61_RS24595	COG0840	transmembrane signaling receptor activity
EXW61_RS24595	COG3290	protein histidine kinase activity
EXW61_RS24605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW61_RS24610	COG0765	amino acid transport
EXW61_RS24620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW61_RS24620	COG0723	plastoquinol--plastocyanin reductase activity
EXW61_RS24625	COG2814	Major facilitator Superfamily
EXW61_RS24630	COG3541	Predicted nucleotidyltransferase
EXW61_RS24650	COG5002	protein histidine kinase activity
EXW61_RS24675	COG0166	Belongs to the GPI family
EXW61_RS24685	COG0492	ferredoxin-NADP+ reductase activity
EXW61_RS24690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS24695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS24700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS24710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW61_RS24720	COG0450	alkyl hydroperoxide reductase
EXW61_RS24735	COG1473	amidohydrolase
EXW61_RS24740	COG1757	Na H antiporter
EXW61_RS24765	COG4807	Protein conserved in bacteria
EXW61_RS24770	COG5002	protein histidine kinase activity
EXW61_RS24775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW61_RS24785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS24800	COG2309	aminopeptidase activity
EXW61_RS24805	COG2076	Multidrug Resistance protein
EXW61_RS24810	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS24820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS24830	COG1597	lipid kinase activity
EXW61_RS24835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW61_RS24840	COG0154	amidase activity
EXW61_RS24850	COG4682	membrane
EXW61_RS24855	COG1846	Transcriptional regulator
EXW61_RS24860	COG0003	Pfam Anion-transporting ATPase
EXW61_RS24875	COG1464	Belongs to the NlpA lipoprotein family
EXW61_RS24880	COG2011	ABC-type metal ion transport system permease component
EXW61_RS24890	COG1335	isochorismatase
EXW61_RS24895	COG1012	belongs to the aldehyde dehydrogenase family
EXW61_RS24905	COG4851	CamS sex pheromone cAM373 precursor
EXW61_RS24910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW61_RS24915	COG0210	DNA helicase
EXW61_RS24920	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW61_RS24940	COG0151	Belongs to the GarS family
EXW61_RS24945	COG0138	bifunctional purine biosynthesis protein purh
EXW61_RS24950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW61_RS24955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW61_RS24960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW61_RS24965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW61_RS24970	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW61_RS24975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW61_RS24980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW61_RS24985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW61_RS24990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW61_RS24995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW61_RS25020	COG0697	spore germination
EXW61_RS25040	COG0745	RESPONSE REGULATOR receiver
EXW61_RS25045	COG2205	protein histidine kinase activity
EXW61_RS25105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW61_RS25125	COG5002	protein histidine kinase activity
EXW61_RS25135	COG2252	PERMEase
EXW61_RS25140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW61_RS25140	COG0519	Catalyzes the synthesis of GMP from XMP
EXW61_RS25145	COG0459	protein refolding
EXW61_RS25150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW61_RS25155	COG1266	CAAX protease self-immunity
EXW61_RS25165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW61_RS25170	COG0488	(ABC) transporter
EXW61_RS25180	COG0456	acetyltransferase
EXW61_RS25185	COG1214	PFAM Peptidase M22, glycoprotease
EXW61_RS25190	COG0802	atpase or kinase
EXW61_RS25290	COG2183	response to ionizing radiation
EXW61_RS25295	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW61_RS25300	COG0864	Transcriptional regulator
EXW61_RS25305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW61_RS25310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW61_RS25315	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW61_RS25320	COG0705	Rhomboid family
EXW61_RS25325	COG4294	response to UV
EXW61_RS25335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW61_RS25345	COG2814	Major facilitator Superfamily
EXW61_RS25350	COG0531	amino acid
EXW61_RS25360	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW61_RS25365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW61_RS25385	COG0561	phosphatase activity
EXW61_RS25390	COG4608	Belongs to the ABC transporter superfamily
EXW61_RS25395	COG0444	Belongs to the ABC transporter superfamily
EXW61_RS25400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW61_RS25405	COG0601	transmembrane transport
EXW61_RS25415	COG0747	negative chemotaxis
EXW61_RS25425	COG0842	Transport permease protein
EXW61_RS25430	COG0842	Transport permease protein
EXW61_RS25430	COG1511	domain protein
EXW61_RS25435	COG1131	(ABC) transporter
EXW61_RS25440	COG2197	response regulator
EXW61_RS25445	COG4585	Histidine kinase
EXW61_RS25450	COG0488	(ABC) transporter
EXW61_RS25470	COG5298	Protein conserved in bacteria
EXW61_RS25485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW61_RS25495	COG1609	Transcriptional regulator
EXW61_RS25505	COG0204	Acyl-transferase
EXW61_RS25520	COG0697	spore germination
EXW61_RS25535	COG1910	domain protein
EXW61_RS25540	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW61_RS25545	COG4149	molybdate abc transporter
EXW61_RS25560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW61_RS25565	COG0656	L-ascorbic acid biosynthetic process
EXW61_RS25570	COG4166	transmembrane transport
EXW61_RS25575	COG4166	transmembrane transport
EXW61_RS25590	COG2207	Transcriptional regulator
EXW61_RS25600	COG4166	transmembrane transport
EXW61_RS25605	COG4608	Belongs to the ABC transporter superfamily
EXW61_RS25610	COG0444	Belongs to the ABC transporter superfamily
EXW61_RS25615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW61_RS25620	COG0601	transmembrane transport
EXW61_RS25640	COG2814	Major facilitator Superfamily
EXW61_RS25650	COG2271	Major facilitator Superfamily
EXW61_RS25655	COG0277	FAD linked oxidase domain protein
EXW61_RS25665	COG0604	alcohol dehydrogenase
EXW61_RS25670	COG1464	Belongs to the NlpA lipoprotein family
EXW61_RS25680	COG2011	ABC-type metal ion transport system permease component
EXW61_RS25685	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS25720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW61_RS25725	COG4856	YbbR-like protein
EXW61_RS25730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW61_RS25810	COG0726	polysaccharide deacetylase
EXW61_RS25815	COG2194	sulfuric ester hydrolase activity
EXW61_RS25825	COG0489	protein tyrosine kinase activity
EXW61_RS25830	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW61_RS25840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW61_RS25845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW61_RS25855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW61_RS25880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW61_RS25885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW61_RS25890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW61_RS25900	COG0024	Methionine aminopeptidase
EXW61_RS25905	COG0563	adenylate kinase activity
EXW61_RS25910	COG0201	protein transport
EXW61_RS25915	COG0200	Binds to the 23S rRNA
EXW61_RS25920	COG1841	ribosomal large subunit assembly
EXW61_RS25930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW61_RS25940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW61_RS25950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW61_RS25955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW61_RS25965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW61_RS25970	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW61_RS25985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW61_RS25990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW61_RS25995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW61_RS26000	COG0089	rRNA binding
EXW61_RS26005	COG0088	Forms part of the polypeptide exit tunnel
EXW61_RS26010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW61_RS26015	COG0051	transcription antitermination factor activity, RNA binding
EXW61_RS26020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW61_RS26025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW61_RS26035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW61_RS26040	COG1358	cellular component organization or biogenesis
EXW61_RS26045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW61_RS26050	COG0085	RNA polymerase activity
EXW61_RS26055	COG2813	Specifically methylates the guanine in position
EXW61_RS26060	COG0222	ribosome binding
EXW61_RS26065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW61_RS26070	COG0081	regulation of translation
EXW61_RS26075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW61_RS26080	COG0250	Participates in transcription elongation, termination and antitermination
EXW61_RS26085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW61_RS26090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW61_RS26100	COG3688	RNA-binding protein containing a PIN domain
EXW61_RS26105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW61_RS26115	COG0215	cysteine-tRNA ligase activity
EXW61_RS26120	COG1045	serine acetyltransferase
EXW61_RS26125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW61_RS26135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW61_RS26140	COG4956	integral membrane protein (PIN domain superfamily)
EXW61_RS26145	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW61_RS26150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW61_RS26155	COG0542	response to heat
EXW61_RS26160	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW61_RS26165	COG3880	PFAM UvrB UvrC protein
EXW61_RS26250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW61_RS26255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW61_RS26260	COG1396	sequence-specific DNA binding
EXW61_RS26265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW61_RS26270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW61_RS26275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW61_RS26280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW61_RS26285	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW61_RS26290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW61_RS26295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW61_RS26300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW61_RS26305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW61_RS26310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW61_RS26315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW61_RS26325	COG2208	phosphoserine phosphatase activity
EXW61_RS26340	COG1098	S1 RNA binding domain
EXW61_RS26360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW61_RS26365	COG3956	TIGRFAM MazG family protein
EXW61_RS26370	COG2244	polysaccharide biosynthetic process
EXW61_RS26375	COG2002	toxin-antitoxin pair type II binding
EXW61_RS26380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW61_RS26400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW61_RS26405	COG2088	sporulation resulting in formation of a cellular spore
EXW61_RS26410	COG0251	oxidation-reduction process
EXW61_RS26415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW61_RS26420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW61_RS26430	COG4466	Protein conserved in bacteria
EXW61_RS26440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW61_RS26450	COG0084	hydrolase, TatD family'
EXW61_RS26460	COG2002	toxin-antitoxin pair type II binding
EXW61_RS26465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW61_RS26475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW61_RS26480	COG4467	Involved in initiation control of chromosome replication
EXW61_RS26485	COG1774	PSP1 C-terminal conserved region
EXW61_RS26490	COG0470	DNA polymerase III
EXW61_RS26495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW61_RS26500	COG1982	Orn Lys Arg decarboxylase major
EXW61_RS26545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW61_RS26550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW61_RS26555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW61_RS26565	COG0590	tRNA wobble adenosine to inosine editing
EXW61_RS26570	COG1335	isochorismatase
EXW61_RS26575	COG1428	Deoxynucleoside kinase
EXW61_RS26580	COG1428	Deoxynucleoside kinase
EXW61_RS26600	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW61_RS26605	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW61_RS26610	COG1686	Belongs to the peptidase S11 family
EXW61_RS26615	COG0516	GMP reductase activity
EXW61_RS26615	COG0517	IMP dehydrogenase activity
EXW61_RS26650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW61_RS26655	COG0187	DNA topoisomerase II activity
EXW61_RS26660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW61_RS26665	COG2501	S4 domain
EXW61_RS26670	COG0592	DNA-directed DNA polymerase activity
EXW61_RS26675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW61_RS26680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW61_RS26685	COG0594	ribonuclease P activity
EXW61_RS26690	COG0706	membrane insertase activity
EXW61_RS26695	COG1847	R3H domain protein
EXW61_RS26700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW61_RS26705	COG0445	tRNA wobble uridine modification
EXW61_RS26715	COG1475	DNA binding
EXW61_RS26720	COG1192	Involved in chromosome partitioning
EXW61_RS26725	COG1475	DNA binding
EXW61_RS26735	COG0668	transmembrane transport
EXW61_RS26740	COG4481	Protein conserved in bacteria
EXW61_RS26745	COG0012	GTP binding
EXW61_RS26750	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW61_RS26755	COG0629	single-stranded DNA binding
EXW61_RS26765	COG4241	membrane
EXW61_RS26770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW61_RS26775	COG0359	binds to the 23S rRNA
EXW61_RS26780	COG0305	Participates in initiation and elongation during chromosome replication
EXW61_RS26810	COG0745	RESPONSE REGULATOR receiver
EXW61_RS26815	COG5002	protein histidine kinase activity
EXW61_RS26825	COG4853	Protein conserved in bacteria
EXW61_RS26830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW61_RS26835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW61_RS26845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW61_RS26855	COG1164	Oligoendopeptidase f
EXW61_RS26885	COG1272	protein, Hemolysin III
EXW61_RS26890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW61_RS26940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW61_RS26945	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW61_RS26950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW61_RS26955	COG2814	Major facilitator Superfamily
EXW61_RS26960	COG3275	phosphorelay sensor kinase activity
EXW61_RS26965	COG3279	Response regulator of the LytR AlgR family
EXW61_RS26970	COG1380	Effector of murein hydrolase LrgA
EXW61_RS26975	COG1346	cytolysis
EXW61_RS26980	COG0628	permease
EXW61_RS26985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW61_RS26985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW61_RS26990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW61_RS26995	COG1309	transcriptional regulator
EXW61_RS27005	COG1696	Membrane protein involved in D-alanine export
EXW61_RS27010	COG0488	(ABC) transporter
EXW61_RS27015	COG1216	Glycosyl transferase, family 2
EXW61_RS27030	COG1216	Glycosyl transferase, family 2
EXW61_RS27035	COG1607	acyl-coa hydrolase
EXW61_RS27045	COG0840	transmembrane signaling receptor activity
EXW61_RS27070	COG0477	Major facilitator Superfamily
EXW61_RS27075	COG3279	Response regulator of the LytR AlgR family
EXW61_RS27080	COG1966	Carbon starvation protein
EXW61_RS27085	COG2879	small protein
EXW61_RS27090	COG3706	GGDEF domain
EXW61_RS27095	COG0351	phosphomethylpyrimidine kinase
EXW61_RS27100	COG4585	Histidine kinase
EXW61_RS27100	COG2203	Gaf domain
EXW61_RS27105	COG2197	response regulator
EXW61_RS27120	COG2873	o-acetylhomoserine
EXW61_RS27125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW61_RS27130	COG0460	homoserine dehydrogenase
EXW61_RS27140	COG1609	Transcriptional regulator
EXW61_RS27145	COG2755	lipolytic protein G-D-S-L family
EXW61_RS27150	COG1131	(ABC) transporter
EXW61_RS27155	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW61_RS27160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW61_RS27165	COG2814	Major facilitator Superfamily
EXW61_RS27170	COG0561	phosphatase activity
EXW61_RS27175	COG2233	PERMEase
EXW61_RS27190	COG2363	Small membrane protein
EXW61_RS27200	COG3773	Cell wall hydrolase
EXW61_RS27210	COG3253	May function as heme-dependent peroxidase
EXW61_RS27215	COG0280	phosphate acetyltransferase
EXW61_RS27230	COG4844	belongs to the
EXW61_RS27235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS27240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW61_RS27245	COG1120	ATPase activity
EXW61_RS27250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW61_RS27255	COG1078	dGTPase activity
EXW61_RS27265	COG1994	Peptidase M50
EXW61_RS27275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW61_RS27280	COG0584	glycerophosphoryl diester phosphodiesterase
EXW61_RS27285	COG0789	Transcriptional regulator
EXW61_RS27290	COG2814	Major facilitator Superfamily
EXW61_RS27295	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW61_RS27300	COG0010	Belongs to the arginase family
EXW61_RS27315	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW61_RS27320	COG4506	Protein conserved in bacteria
EXW61_RS27335	COG2234	aminopeptidase activity
EXW61_RS27340	COG0024	Methionine aminopeptidase
EXW61_RS27345	COG1131	(ABC) transporter
EXW61_RS27350	COG0842	Transport permease protein
EXW61_RS27355	COG4585	Histidine kinase
EXW61_RS27360	COG2197	response regulator
EXW61_RS27380	COG3300	MHYT domain
EXW61_RS27380	COG5001	Diguanylate cyclase
EXW61_RS27385	COG4294	response to UV
EXW61_RS27390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW61_RS27395	COG0247	lactate metabolic process
EXW61_RS27395	COG2181	nitrate reductase activity
EXW61_RS27400	COG0183	Belongs to the thiolase family
EXW61_RS27405	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW61_RS27410	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS27415	COG1960	acyl-CoA dehydrogenase activity
EXW61_RS27425	COG3343	RNA polymerase activity
EXW61_RS27430	COG0504	CTP synthase activity
EXW61_RS27435	COG4821	SIS domain
EXW61_RS27455	COG1494	fructose-1,6-bisphosphatase
EXW61_RS27460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW61_RS27470	COG1435	thymidine kinase activity
EXW61_RS27475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW61_RS27480	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW61_RS27495	COG0009	L-threonylcarbamoyladenylate synthase
EXW61_RS27500	COG1971	Probably functions as a manganese efflux pump
EXW61_RS27510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW61_RS27515	COG2259	Doxx family
EXW61_RS27520	COG2190	(PTS) system
EXW61_RS27530	COG0698	ribose 5-phosphate isomerase
EXW61_RS27540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW61_RS27565	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW61_RS27575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW61_RS27580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW61_RS27585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW61_RS27590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW61_RS27595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW61_RS27600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW61_RS27615	COG5001	Diguanylate cyclase
EXW61_RS27615	COG3300	MHYT domain
EXW61_RS27620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW61_RS27625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW61_RS27630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW61_RS27635	COG0649	NAD binding
EXW61_RS27640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW61_RS27650	COG0839	Belongs to the complex I subunit 6 family
EXW61_RS27655	COG0713	ATP synthesis coupled electron transport
EXW61_RS27660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW61_RS27665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW61_RS27670	COG1007	ATP synthesis coupled electron transport
EXW61_RS27675	COG4836	Membrane
EXW61_RS27690	COG2385	sporulation resulting in formation of a cellular spore
EXW61_RS27730	COG4555	ABC transporter
EXW61_RS27745	COG0739	heme binding
EXW61_RS27755	COG1609	Transcriptional regulator
EXW61_RS27770	COG0489	protein tyrosine kinase activity
EXW61_RS27775	COG3944	biosynthesis protein
EXW61_RS27780	COG0489	protein tyrosine kinase activity
EXW61_RS27785	COG4464	protein tyrosine phosphatase activity
EXW61_RS27790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW61_RS27795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW61_RS27800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW61_RS27815	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS27840	COG0438	transferase activity, transferring glycosyl groups
EXW61_RS27860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW61_RS27865	COG0745	RESPONSE REGULATOR receiver
EXW61_RS27870	COG5002	protein histidine kinase activity
EXW61_RS27870	COG3850	Histidine kinase
EXW61_RS27895	COG1136	(ABC) transporter
EXW61_RS27900	COG0577	efflux transmembrane transporter activity
EXW61_RS27940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW61_RS27945	COG4715	Zinc finger, swim domain protein
EXW61_RS27970	COG1388	LysM domain
EXW61_RS27970	COG3584	3D domain protein
EXW61_RS27975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW61_RS27980	COG1215	transferase activity, transferring glycosyl groups
EXW61_RS27990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW61_RS27995	COG0791	NLP P60 protein
EXW61_RS27995	COG1388	LysM domain
EXW61_RS28005	COG1368	sulfuric ester hydrolase activity
EXW61_RS28015	COG2389	metal-binding protein
EXW61_RS28025	COG1620	l-lactate permease
EXW61_RS28030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW61_RS28035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW61_RS28040	COG1294	oxidase, subunit
EXW61_RS28045	COG1271	oxidase subunit
EXW61_RS28055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW61_RS28060	COG0583	DNA-binding transcription factor activity
EXW61_RS28065	COG1511	domain protein
EXW61_RS28080	COG1301	dicarboxylic acid transport
EXW61_RS28085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW61_RS28095	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW61_RS28110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW61_RS28115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW61_RS28120	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW61_RS28125	COG1486	melibiose metabolic process
EXW61_RS28145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW61_RS28145	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW61_RS28155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW61_RS28160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW61_RS28165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW61_RS28170	COG1316	TRANSCRIPTIONal
EXW61_RS28175	COG1739	Uncharacterized protein family UPF0029
EXW61_RS28180	COG1307	EDD domain protein, DegV family
EXW61_RS28185	COG1733	regulation of RNA biosynthetic process
EXW61_RS28190	COG0791	NLP P60 protein
EXW61_RS28190	COG1388	LysM domain
EXW61_RS28200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW61_RS28205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW61_RS28315	COG1484	DNA-dependent DNA replication
EXW61_RS28345	COG3331	DNA recombination
EXW61_RS28380	COG5484	DNA packaging
EXW61_RS28390	COG5518	Phage portal protein
EXW61_RS28395	COG2369	cell adhesion
EXW61_RS28410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW61_RS28415	COG4653	Phage capsid family
EXW61_RS28490	COG4824	toxin secretion phage lysis holin
EXW61_RS28705	COG3764	Sortase (surface protein transpeptidase)
EXW61_RS28785	COG5002	protein histidine kinase activity
EXW61_RS28830	COG0384	phenazine biosynthesis protein PhzF
EXW61_RS28835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EXW61_RS28855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW61_RS28890	COG0741	lytic transglycosylase activity
EXW61_RS28900	COG0745	RESPONSE REGULATOR receiver
EXW61_RS28910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW61_RS28915	COG0577	efflux transmembrane transporter activity
EXW61_RS28920	COG1136	(ABC) transporter
EXW61_RS28930	COG0456	acetyltransferase
EXW61_RS28940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW61_RS28945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW61_RS28950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW61_RS28965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW61_RS28975	COG2234	aminopeptidase activity
EXW61_RS28980	COG2814	Major facilitator Superfamily
EXW61_RS29000	COG1404	Belongs to the peptidase S8 family
EXW61_RS29125	COG0367	asparagine synthase
EXW61_RS29145	COG0463	Glycosyl transferase, family 2
EXW61_RS29150	COG0463	Glycosyl transferase, family 2
EXW61_RS29155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW61_RS29160	COG1086	Polysaccharide biosynthesis protein
EXW61_RS29165	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW61_RS29170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW61_RS29175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW61_RS29190	COG2089	acid synthase
EXW61_RS29195	COG4641	Protein conserved in bacteria
EXW61_RS29260	COG0745	RESPONSE REGULATOR receiver
EXW61_RS29265	COG2205	protein histidine kinase activity
EXW61_RS29275	COG1136	(ABC) transporter
EXW61_RS29280	COG0577	efflux transmembrane transporter activity
EXW61_RS29290	COG2002	toxin-antitoxin pair type II binding
EXW61_RS29300	COG1923	regulation of RNA biosynthetic process
EXW61_RS29340	COG2814	Major facilitator Superfamily
EXW61_RS29370	COG1028	Short-chain dehydrogenase reductase Sdr
EXW61_RS29385	COG1999	signal sequence binding
EXW61_RS29390	COG0662	Cupin 2, conserved barrel domain protein
EXW61_RS29395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW61_RS29400	COG0010	Belongs to the arginase family
EXW61_RS29410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW61_RS29425	COG0456	acetyltransferase
EXW61_RS29470	COG2002	toxin-antitoxin pair type II binding
EXW61_RS29480	COG4974	Belongs to the 'phage' integrase family
EXW61_RS29560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW61_RS29660	COG0745	RESPONSE REGULATOR receiver
EXW61_RS29685	COG0833	amino acid
EXW61_RS29690	COG1285	pathogenesis
EXW61_RS29695	COG2267	carboxylic ester hydrolase activity
EXW61_RS29705	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW61_RS29710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW61_RS29715	COG0772	Belongs to the SEDS family
EXW61_RS29720	COG2239	Acts as a magnesium transporter
EXW61_RS29730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW61_RS29740	COG4974	Belongs to the 'phage' integrase family
EXW61_RS29825	COG2357	RelA SpoT domain protein
EXW61_RS29830	COG2814	Major facilitator Superfamily
EXW61_RS29855	COG1725	Transcriptional regulator
EXW61_RS29860	COG1131	(ABC) transporter
EXW61_RS29895	COG1329	Transcriptional regulator
EXW61_RS29915	COG3344	reverse transcriptase
EXW61_RS29950	COG4176	ABC-type proline glycine betaine transport system permease component
EXW61_RS29955	COG4175	Glycine betaine
EXW61_RS29955	COG0517	IMP dehydrogenase activity
EXW61_RS30020	COG0156	8-amino-7-oxononanoate synthase activity
EXW61_RS30030	COG4974	Belongs to the 'phage' integrase family
EXW61_RS30040	COG1132	(ABC) transporter
EXW61_RS30050	COG2814	Major facilitator Superfamily
EXW61_RS30075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW61_RS30085	COG0582	viral genome integration into host DNA
EXW61_RS30170	COG2002	toxin-antitoxin pair type II binding
EXW61_RS30240	COG3883	PFAM NLP P60 protein
EXW61_RS30240	COG0791	NLP P60 protein
EXW61_RS30335	COG1396	sequence-specific DNA binding
EXW61_RS30370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW61_RS30375	COG4974	Belongs to the 'phage' integrase family
EXW61_RS30380	COG0024	Methionine aminopeptidase
EXW61_RS30395	COG0582	viral genome integration into host DNA
EXW61_RS30425	COG1695	Transcriptional regulator
EXW61_RS30550	COG0572	uridine kinase
EXW61_RS30705	COG2814	Major facilitator Superfamily