locus-tag	class	description
DN409_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DN409_RS00010	COG0592	DNA-directed DNA polymerase activity
DN409_RS00015	COG2501	S4 domain
DN409_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DN409_RS00025	COG0187	DNA topoisomerase II activity
DN409_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN409_RS00065	COG0517	IMP dehydrogenase activity
DN409_RS00065	COG0516	GMP reductase activity
DN409_RS00070	COG1686	Belongs to the peptidase S11 family
DN409_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DN409_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DN409_RS00100	COG1428	Deoxynucleoside kinase
DN409_RS00105	COG1428	Deoxynucleoside kinase
DN409_RS00110	COG1335	isochorismatase
DN409_RS00115	COG0590	tRNA wobble adenosine to inosine editing
DN409_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DN409_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DN409_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DN409_RS00180	COG1982	Orn Lys Arg decarboxylase major
DN409_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DN409_RS00190	COG0470	DNA polymerase III
DN409_RS00195	COG1774	PSP1 C-terminal conserved region
DN409_RS00200	COG4467	Involved in initiation control of chromosome replication
DN409_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DN409_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DN409_RS00220	COG2002	toxin-antitoxin pair type II binding
DN409_RS00230	COG0084	hydrolase, TatD family'
DN409_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DN409_RS00250	COG4466	Protein conserved in bacteria
DN409_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DN409_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN409_RS00270	COG0251	oxidation-reduction process
DN409_RS00275	COG2088	sporulation resulting in formation of a cellular spore
DN409_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DN409_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DN409_RS00305	COG2002	toxin-antitoxin pair type II binding
DN409_RS00310	COG2244	polysaccharide biosynthetic process
DN409_RS00315	COG3956	TIGRFAM MazG family protein
DN409_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DN409_RS00340	COG1098	S1 RNA binding domain
DN409_RS00355	COG2208	phosphoserine phosphatase activity
DN409_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN409_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN409_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DN409_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DN409_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN409_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DN409_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
DN409_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN409_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DN409_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DN409_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DN409_RS00420	COG1396	sequence-specific DNA binding
DN409_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN409_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DN409_RS00520	COG3880	PFAM UvrB UvrC protein
DN409_RS00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DN409_RS00530	COG0542	response to heat
DN409_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DN409_RS00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DN409_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
DN409_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DN409_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN409_RS00565	COG1045	serine acetyltransferase
DN409_RS00570	COG0215	cysteine-tRNA ligase activity
DN409_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN409_RS00585	COG3688	RNA-binding protein containing a PIN domain
DN409_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN409_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN409_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
DN409_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DN409_RS00615	COG0081	regulation of translation
DN409_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DN409_RS00625	COG0222	ribosome binding
DN409_RS00630	COG2813	Specifically methylates the guanine in position
DN409_RS00635	COG0085	RNA polymerase activity
DN409_RS00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DN409_RS00645	COG1358	cellular component organization or biogenesis
DN409_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DN409_RS00655	COG0049	tRNA binding
DN409_RS00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN409_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DN409_RS00670	COG0051	transcription antitermination factor activity, RNA binding
DN409_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DN409_RS00680	COG0088	Forms part of the polypeptide exit tunnel
DN409_RS00685	COG0089	rRNA binding
DN409_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DN409_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DN409_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DN409_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DN409_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
DN409_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DN409_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DN409_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DN409_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DN409_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DN409_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DN409_RS00765	COG1841	ribosomal large subunit assembly
DN409_RS00770	COG0200	Binds to the 23S rRNA
DN409_RS00775	COG0201	protein transport
DN409_RS00780	COG0563	adenylate kinase activity
DN409_RS00785	COG0024	Methionine aminopeptidase
DN409_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DN409_RS00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DN409_RS00805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DN409_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DN409_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DN409_RS00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DN409_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS00860	COG0489	protein tyrosine kinase activity
DN409_RS00870	COG2194	sulfuric ester hydrolase activity
DN409_RS00875	COG0726	polysaccharide deacetylase
DN409_RS00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DN409_RS00960	COG4856	YbbR-like protein
DN409_RS00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN409_RS00980	COG1506	peptidase
DN409_RS00980	COG4946	Tricorn protease homolog
DN409_RS00980	COG0823	Involved in the tonB-independent uptake of proteins
DN409_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS01010	COG2011	ABC-type metal ion transport system permease component
DN409_RS01020	COG1464	Belongs to the NlpA lipoprotein family
DN409_RS01035	COG0277	FAD linked oxidase domain protein
DN409_RS01040	COG2271	Major facilitator Superfamily
DN409_RS01050	COG2814	Major facilitator Superfamily
DN409_RS01070	COG0601	transmembrane transport
DN409_RS01075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN409_RS01080	COG0444	Belongs to the ABC transporter superfamily
DN409_RS01085	COG4608	Belongs to the ABC transporter superfamily
DN409_RS01090	COG4166	transmembrane transport
DN409_RS01105	COG4166	transmembrane transport
DN409_RS01110	COG4166	transmembrane transport
DN409_RS01115	COG0656	L-ascorbic acid biosynthetic process
DN409_RS01120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN409_RS01135	COG4149	molybdate abc transporter
DN409_RS01140	COG0725	ABC transporter, periplasmic molybdate-binding protein
DN409_RS01145	COG1910	domain protein
DN409_RS01160	COG0697	spore germination
DN409_RS01175	COG0204	Acyl-transferase
DN409_RS01185	COG1609	Transcriptional regulator
DN409_RS01195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS01210	COG5298	Protein conserved in bacteria
DN409_RS01235	COG0488	(ABC) transporter
DN409_RS01240	COG4585	Histidine kinase
DN409_RS01250	COG1131	(ABC) transporter
DN409_RS01255	COG0842	Transport permease protein
DN409_RS01255	COG1511	domain protein
DN409_RS01260	COG0842	Transport permease protein
DN409_RS01270	COG0747	negative chemotaxis
DN409_RS01275	COG0601	transmembrane transport
DN409_RS01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN409_RS01285	COG0444	Belongs to the ABC transporter superfamily
DN409_RS01290	COG4608	Belongs to the ABC transporter superfamily
DN409_RS01295	COG0561	phosphatase activity
DN409_RS01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DN409_RS01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN409_RS01340	COG0531	amino acid
DN409_RS01345	COG2814	Major facilitator Superfamily
DN409_RS01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DN409_RS01365	COG4294	response to UV
DN409_RS01370	COG0705	Rhomboid family
DN409_RS01375	COG0736	holo-[acyl-carrier-protein] synthase activity
DN409_RS01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DN409_RS01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN409_RS01390	COG0864	Transcriptional regulator
DN409_RS01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
DN409_RS01400	COG2183	response to ionizing radiation
DN409_RS01500	COG0802	atpase or kinase
DN409_RS01505	COG1214	PFAM Peptidase M22, glycoprotease
DN409_RS01510	COG0456	acetyltransferase
DN409_RS01520	COG0488	(ABC) transporter
DN409_RS01525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DN409_RS01535	COG1266	CAAX protease self-immunity
DN409_RS01540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DN409_RS01545	COG0459	protein refolding
DN409_RS01550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DN409_RS01550	COG0519	Catalyzes the synthesis of GMP from XMP
DN409_RS01555	COG2252	PERMEase
DN409_RS01565	COG5002	protein histidine kinase activity
DN409_RS01595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DN409_RS01625	COG2226	methyltransferase
DN409_RS01645	COG1215	transferase activity, transferring glycosyl groups
DN409_RS01670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS01675	COG0506	proline dehydrogenase activity
DN409_RS01695	COG0697	spore germination
DN409_RS01725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DN409_RS01730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DN409_RS01735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN409_RS01740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DN409_RS01745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN409_RS01750	COG0047	phosphoribosylformylglycinamidine synthase activity
DN409_RS01755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN409_RS01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DN409_RS01765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DN409_RS01770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DN409_RS01775	COG0138	bifunctional purine biosynthesis protein purh
DN409_RS01780	COG0151	Belongs to the GarS family
DN409_RS01805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DN409_RS01810	COG0210	DNA helicase
DN409_RS01815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DN409_RS01820	COG4851	CamS sex pheromone cAM373 precursor
DN409_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS01835	COG1335	isochorismatase
DN409_RS01845	COG2011	ABC-type metal ion transport system permease component
DN409_RS01850	COG1464	Belongs to the NlpA lipoprotein family
DN409_RS01865	COG0003	Pfam Anion-transporting ATPase
DN409_RS01870	COG1846	Transcriptional regulator
DN409_RS01875	COG4682	membrane
DN409_RS01885	COG0154	amidase activity
DN409_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DN409_RS01895	COG1597	lipid kinase activity
DN409_RS01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN409_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS01920	COG2076	Multidrug Resistance protein
DN409_RS01925	COG2309	aminopeptidase activity
DN409_RS01940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS01950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN409_RS01955	COG5002	protein histidine kinase activity
DN409_RS01960	COG4807	Protein conserved in bacteria
DN409_RS01985	COG1757	Na H antiporter
DN409_RS01990	COG1473	amidohydrolase
DN409_RS02005	COG0450	alkyl hydroperoxide reductase
DN409_RS02015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DN409_RS02025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS02035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS02045	COG0492	ferredoxin-NADP+ reductase activity
DN409_RS02060	COG0166	Belongs to the GPI family
DN409_RS02085	COG5002	protein histidine kinase activity
DN409_RS02105	COG3541	Predicted nucleotidyltransferase
DN409_RS02110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN409_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
DN409_RS02120	COG0765	amino acid transport
DN409_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS02135	COG0840	transmembrane signaling receptor activity
DN409_RS02140	COG0277	FAD linked oxidase domain protein
DN409_RS02145	COG0366	Alpha amylase catalytic
DN409_RS02150	COG2190	(PTS) system
DN409_RS02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS02150	COG1263	PTS System
DN409_RS02170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DN409_RS02180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DN409_RS02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN409_RS02200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN409_RS02205	COG1116	anion transmembrane transporter activity
DN409_RS02210	COG0488	(ABC) transporter
DN409_RS02245	COG2270	Major facilitator Superfamily
DN409_RS02275	COG2310	stress, protein
DN409_RS02280	COG2310	stress, protein
DN409_RS02285	COG2310	stress, protein
DN409_RS02290	COG0861	Integral membrane protein TerC family
DN409_RS02300	COG3853	Toxic anion resistance protein (TelA)
DN409_RS02310	COG4840	Belongs to the UPF0435 family
DN409_RS02315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN409_RS02325	COG1295	ribonuclease BN
DN409_RS02330	COG2217	Heavy metal translocating P-type atpase
DN409_RS02335	COG0697	spore germination
DN409_RS02360	COG0586	Pfam SNARE associated Golgi protein
DN409_RS02375	COG3871	stress protein (general stress protein 26)
DN409_RS02380	COG0387	Pfam Sodium calcium exchanger
DN409_RS02390	COG0535	radical SAM domain protein
DN409_RS02410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DN409_RS02430	COG3829	transcription factor binding
DN409_RS02440	COG0833	amino acid
DN409_RS02445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN409_RS02465	COG2066	Belongs to the glutaminase family
DN409_RS02475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS02475	COG1263	PTS System
DN409_RS02480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS02495	COG1216	Glycosyl transferase, family 2
DN409_RS02505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN409_RS02505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN409_RS02510	COG0463	Glycosyl transferase, family 2
DN409_RS02525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DN409_RS02530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DN409_RS02545	COG1228	amidohydrolase
DN409_RS02550	COG1090	epimerase
DN409_RS02555	COG2137	regulation of response to DNA damage stimulus
DN409_RS02580	COG1988	membrane-bound metal-dependent
DN409_RS02585	COG1194	a g-specific adenine glycosylase
DN409_RS02605	COG3557	Belongs to the UPF0374 family
DN409_RS02610	COG1132	(ABC) transporter
DN409_RS02615	COG4129	membrane
DN409_RS02620	COG0069	glutamate synthase activity
DN409_RS02620	COG0070	glutamate synthase
DN409_RS02620	COG0067	glutamate synthase
DN409_RS02625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DN409_RS02630	COG4555	ABC transporter
DN409_RS02650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DN409_RS02655	COG0735	belongs to the Fur family
DN409_RS02775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DN409_RS02780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DN409_RS02800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DN409_RS02810	COG2766	serine protein kinase
DN409_RS02815	COG2718	Belongs to the UPF0229 family
DN409_RS02830	COG1585	Membrane protein implicated in regulation of membrane protease activity
DN409_RS02835	COG2268	Band 7 protein
DN409_RS02845	COG3290	protein histidine kinase activity
DN409_RS02850	COG4565	transcriptional regulatory protein
DN409_RS02855	COG2851	Citrate transporter
DN409_RS02880	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DN409_RS02885	COG3842	ATPase activity
DN409_RS02890	COG1175	transmembrane transport
DN409_RS02895	COG0395	ABC-type sugar transport system, permease component
DN409_RS02905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN409_RS02910	COG0745	RESPONSE REGULATOR receiver
DN409_RS02915	COG5002	protein histidine kinase activity
DN409_RS02925	COG4990	cell redox homeostasis
DN409_RS02935	COG3290	protein histidine kinase activity
DN409_RS02940	COG4565	transcriptional regulatory protein
DN409_RS02945	COG3493	citrate carrier protein
DN409_RS02950	COG0281	malic enzyme
DN409_RS02960	COG0697	spore germination
DN409_RS02965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS02975	COG5002	protein histidine kinase activity
DN409_RS02980	COG0745	RESPONSE REGULATOR receiver
DN409_RS02985	COG0456	acetyltransferase
DN409_RS02990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN409_RS02995	COG3383	formate dehydrogenase (NAD+) activity
DN409_RS03015	COG0531	amino acid
DN409_RS03025	COG0640	Transcriptional regulator
DN409_RS03030	COG2217	Heavy metal translocating P-type atpase
DN409_RS03035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DN409_RS03050	COG3227	Zinc metalloprotease (Elastase)
DN409_RS03070	COG2720	vancomycin resistance protein
DN409_RS03075	COG1316	TRANSCRIPTIONal
DN409_RS03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS03085	COG0346	lactoylglutathione lyase activity
DN409_RS03090	COG1253	flavin adenine dinucleotide binding
DN409_RS03095	COG1027	Aspartate ammonia-lyase
DN409_RS03100	COG1620	l-lactate permease
DN409_RS03105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS03125	COG3104	oligopeptide transport
DN409_RS03130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS03140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS03155	COG0156	8-amino-7-oxononanoate synthase activity
DN409_RS03160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN409_RS03170	COG4548	von Willebrand factor, type A
DN409_RS03175	COG0714	Associated with various cellular activities
DN409_RS03195	COG0531	amino acid
DN409_RS03200	COG2188	Transcriptional regulator
DN409_RS03210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS03210	COG1263	PTS System
DN409_RS03215	COG0366	Alpha amylase catalytic
DN409_RS03230	COG0697	spore germination
DN409_RS03235	COG4585	Histidine kinase
DN409_RS03240	COG2197	response regulator
DN409_RS03245	COG1404	Belongs to the peptidase S8 family
DN409_RS03260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS03265	COG1115	amino acid carrier protein
DN409_RS03270	COG1126	abc transporter atp-binding protein
DN409_RS03275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS03280	COG0765	amino acid transport
DN409_RS03285	COG0765	amino acid transport
DN409_RS03290	COG0833	amino acid
DN409_RS03320	COG2378	regulation of single-species biofilm formation
DN409_RS03325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN409_RS03330	COG5002	protein histidine kinase activity
DN409_RS03345	COG0659	secondary active sulfate transmembrane transporter activity
DN409_RS03370	COG0601	transmembrane transport
DN409_RS03375	COG4608	Belongs to the ABC transporter superfamily
DN409_RS03385	COG2271	Major facilitator Superfamily
DN409_RS03390	COG1846	Transcriptional regulator
DN409_RS03395	COG0477	Major facilitator Superfamily
DN409_RS03400	COG1609	Transcriptional regulator
DN409_RS03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN409_RS03410	COG1869	D-ribose catabolic process
DN409_RS03420	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN409_RS03425	COG1879	ABC-type sugar transport system periplasmic component
DN409_RS03455	COG1063	alcohol dehydrogenase
DN409_RS03470	COG3568	Endonuclease Exonuclease Phosphatase
DN409_RS03500	COG0840	transmembrane signaling receptor activity
DN409_RS03505	COG3583	domain protein
DN409_RS03505	COG3584	3D domain protein
DN409_RS03510	COG1476	TRANSCRIPTIONal
DN409_RS03530	COG3104	oligopeptide transport
DN409_RS03535	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS03550	COG1113	amino acid transport
DN409_RS03555	COG2252	PERMEase
DN409_RS03570	COG2153	protein acetylation
DN409_RS03580	COG0569	domain protein
DN409_RS03580	COG0475	glutathione-regulated potassium exporter activity
DN409_RS03595	COG1845	cytochrome c oxidase, subunit III
DN409_RS03600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DN409_RS03610	COG0833	amino acid
DN409_RS03615	COG4990	cell redox homeostasis
DN409_RS03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN409_RS03635	COG0697	spore germination
DN409_RS03640	COG0531	amino acid
DN409_RS03650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN409_RS03655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN409_RS03665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN409_RS03670	COG0573	inorganic phosphate transmembrane transporter activity
DN409_RS03675	COG0581	inorganic phosphate transmembrane transporter activity
DN409_RS03685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN409_RS03805	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DN409_RS03820	COG4991	sh3 domain protein
DN409_RS03820	COG3103	Sh3 type 3 domain protein
DN409_RS03820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS03825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DN409_RS03830	COG1116	anion transmembrane transporter activity
DN409_RS03835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN409_RS03840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN409_RS03845	COG0352	thiamine-phosphate diphosphorylase activity
DN409_RS03850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN409_RS03855	COG2104	thiamine diphosphate biosynthetic process
DN409_RS03860	COG2022	thiamine diphosphate biosynthetic process
DN409_RS03865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN409_RS03870	COG0351	phosphomethylpyrimidine kinase
DN409_RS03895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DN409_RS03900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DN409_RS03905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DN409_RS03910	COG2205	protein histidine kinase activity
DN409_RS03915	COG2814	Major facilitator Superfamily
DN409_RS03920	COG1846	Transcriptional regulator
DN409_RS03930	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN409_RS03935	COG1129	ABC transporter
DN409_RS03940	COG1879	ABC-type sugar transport system periplasmic component
DN409_RS03945	COG2252	PERMEase
DN409_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS04010	COG0778	Nitroreductase
DN409_RS04015	COG2719	SpoVR family
DN409_RS04040	COG1937	Protein conserved in bacteria
DN409_RS04045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS04045	COG0425	Belongs to the sulfur carrier protein TusA family
DN409_RS04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS04055	COG0425	Belongs to the sulfur carrier protein TusA family
DN409_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS04060	COG0425	Belongs to the sulfur carrier protein TusA family
DN409_RS04065	COG2210	Belongs to the sulfur carrier protein TusA family
DN409_RS04070	COG0730	response to heat
DN409_RS04080	COG1316	TRANSCRIPTIONal
DN409_RS04085	COG0604	alcohol dehydrogenase
DN409_RS04090	COG1283	sodium-dependent phosphate transmembrane transporter activity
DN409_RS04095	COG0604	alcohol dehydrogenase
DN409_RS04100	COG2814	Major facilitator Superfamily
DN409_RS04115	COG3711	transcriptional antiterminator
DN409_RS04115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN409_RS04120	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN409_RS04125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN409_RS04145	COG1388	LysM domain
DN409_RS04145	COG3584	3D domain protein
DN409_RS04150	COG0577	efflux transmembrane transporter activity
DN409_RS04155	COG1136	(ABC) transporter
DN409_RS04165	COG5522	Integral membrane protein (intg_mem_TP0381)
DN409_RS04180	COG0577	efflux transmembrane transporter activity
DN409_RS04185	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS04190	COG3546	catalase activity
DN409_RS04220	COG0586	Pfam SNARE associated Golgi protein
DN409_RS04250	COG0531	amino acid
DN409_RS04255	COG0475	glutathione-regulated potassium exporter activity
DN409_RS04265	COG1737	Transcriptional regulator
DN409_RS04270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DN409_RS04275	COG1263	PTS System
DN409_RS04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS04285	COG2259	Doxx family
DN409_RS04305	COG0697	spore germination
DN409_RS04310	COG1522	sequence-specific DNA binding
DN409_RS04320	COG0300	oxidoreductase activity
DN409_RS04335	COG2076	Multidrug Resistance protein
DN409_RS04340	COG1309	transcriptional regulator
DN409_RS04345	COG2814	Major facilitator Superfamily
DN409_RS04350	COG1733	regulation of RNA biosynthetic process
DN409_RS04370	COG4533	DNA binding
DN409_RS04375	COG2211	Major facilitator Superfamily
DN409_RS04385	COG0693	protein deglycase activity
DN409_RS04395	COG0531	amino acid
DN409_RS04400	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS04415	COG1132	(ABC) transporter
DN409_RS04420	COG1132	(ABC) transporter
DN409_RS04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS04430	COG0765	amino acid transport
DN409_RS04435	COG1126	abc transporter atp-binding protein
DN409_RS04450	COG0189	ligase activity
DN409_RS04460	COG4399	Belongs to the UPF0754 family
DN409_RS04465	COG3679	Belongs to the UPF0342 family
DN409_RS04480	COG0028	Belongs to the TPP enzyme family
DN409_RS04485	COG3527	Alpha-acetolactate decarboxylase
DN409_RS04490	COG0463	Glycosyl transferase, family 2
DN409_RS04495	COG1216	Glycosyl transferase, family 2
DN409_RS04500	COG2094	Belongs to the DNA glycosylase MPG family
DN409_RS04505	COG0561	phosphatase activity
DN409_RS04515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN409_RS04520	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS04525	COG0586	Pfam SNARE associated Golgi protein
DN409_RS04535	COG0789	Transcriptional regulator
DN409_RS04535	COG4978	Transcriptional regulator
DN409_RS04545	COG0659	secondary active sulfate transmembrane transporter activity
DN409_RS04560	COG0653	protein targeting
DN409_RS04565	COG2244	polysaccharide biosynthetic process
DN409_RS04575	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS04580	COG4196	transglutaminase domain protein
DN409_RS04605	COG1024	Enoyl-CoA hydratase
DN409_RS04620	COG1363	Peptidase, m42
DN409_RS04635	COG2318	DinB family
DN409_RS04655	COG0579	oxidoreductase
DN409_RS04685	COG0601	transmembrane transport
DN409_RS04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN409_RS04695	COG0444	Belongs to the ABC transporter superfamily
DN409_RS04700	COG4608	Belongs to the ABC transporter superfamily
DN409_RS04720	COG0477	Major facilitator Superfamily
DN409_RS04725	COG3290	protein histidine kinase activity
DN409_RS04730	COG4565	transcriptional regulatory protein
DN409_RS04735	COG3181	Tripartite tricarboxylate transporter family receptor
DN409_RS04765	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DN409_RS04815	COG0305	Participates in initiation and elongation during chromosome replication
DN409_RS04835	COG1842	Phage shock protein A
DN409_RS04845	COG0477	Major facilitator Superfamily
DN409_RS04885	COG1183	phosphatidylcholine synthase activity
DN409_RS04945	COG2732	(Barnase) inhibitor
DN409_RS04950	COG2814	Major facilitator Superfamily
DN409_RS04955	COG0640	Transcriptional regulator
DN409_RS04980	COG2376	Dihydroxyacetone kinase
DN409_RS05000	COG2376	Dihydroxyacetone kinase
DN409_RS05010	COG1959	2 iron, 2 sulfur cluster binding
DN409_RS05035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN409_RS05050	COG2720	vancomycin resistance protein
DN409_RS05080	COG0076	glutamate decarboxylase activity
DN409_RS05100	COG4085	toxin activity
DN409_RS05100	COG1525	nuclease
DN409_RS05100	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS05145	COG0825	malonyl-CoA metabolic process
DN409_RS05170	COG2807	transmembrane transport
DN409_RS05185	COG4585	Histidine kinase
DN409_RS05190	COG2197	response regulator
DN409_RS05220	COG0420	3'-5' exonuclease activity
DN409_RS05225	COG4717	serine-type aminopeptidase activity
DN409_RS05235	COG0346	lactoylglutathione lyase activity
DN409_RS05240	COG0346	lactoylglutathione lyase activity
DN409_RS05245	COG0457	Tetratricopeptide repeat
DN409_RS05255	COG2267	carboxylic ester hydrolase activity
DN409_RS05270	COG3620	sequence-specific DNA binding
DN409_RS05275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DN409_RS05280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN409_RS05285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN409_RS05290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DN409_RS05295	COG1595	DNA-templated transcription, initiation
DN409_RS05310	COG3973	AAA domain
DN409_RS05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DN409_RS05330	COG1846	Transcriptional regulator
DN409_RS05340	COG0537	adenosine 5'-monophosphoramidase activity
DN409_RS05345	COG1131	(ABC) transporter
DN409_RS05350	COG4473	ABC transporter
DN409_RS05360	COG0247	lactate metabolic process
DN409_RS05365	COG1139	Iron-sulfur cluster binding protein
DN409_RS05370	COG1556	Lactate utilization protein
DN409_RS05415	COG1309	transcriptional regulator
DN409_RS05420	COG3402	PFAM membrane-flanked domain
DN409_RS05425	COG3428	Bacterial PH domain
DN409_RS05465	COG3402	PFAM membrane-flanked domain
DN409_RS05470	COG3428	Bacterial PH domain
DN409_RS05475	COG2329	Antibiotic biosynthesis monooxygenase
DN409_RS05480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN409_RS05485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DN409_RS05490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DN409_RS05495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DN409_RS05515	COG1309	transcriptional regulator
DN409_RS05520	COG1511	domain protein
DN409_RS05555	COG1609	Transcriptional regulator
DN409_RS05565	COG1234	tRNA 3'-trailer cleavage
DN409_RS05570	COG0095	Lipoate-protein ligase
DN409_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS05595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DN409_RS05605	COG4208	sulfate ABC transporter
DN409_RS05650	COG1408	metallophosphoesterase
DN409_RS05655	COG1078	dGTPase activity
DN409_RS05670	COG1595	DNA-templated transcription, initiation
DN409_RS05680	COG2207	Transcriptional regulator
DN409_RS05680	COG3708	Transcriptional regulator
DN409_RS05685	COG2205	protein histidine kinase activity
DN409_RS05690	COG0745	RESPONSE REGULATOR receiver
DN409_RS05710	COG0501	Belongs to the peptidase M48B family
DN409_RS05715	COG0697	spore germination
DN409_RS05745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DN409_RS05750	COG2224	Isocitrate lyase
DN409_RS05760	COG1278	Cold shock
DN409_RS05780	COG4903	ComK protein
DN409_RS05790	COG0398	Pfam SNARE associated Golgi protein
DN409_RS05800	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DN409_RS05805	COG1074	ATP-dependent DNA helicase activity
DN409_RS05855	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN409_RS05880	COG0367	asparagine synthase
DN409_RS05890	COG0753	catalase activity
DN409_RS05895	COG0004	ammonium transporteR
DN409_RS05905	COG1666	GTP binding
DN409_RS05910	COG2996	Protein conserved in bacteria
DN409_RS05925	COG1329	Transcriptional regulator
DN409_RS05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DN409_RS05970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS05985	COG0561	phosphatase activity
DN409_RS06005	COG2267	carboxylic ester hydrolase activity
DN409_RS06020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN409_RS06025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DN409_RS06030	COG5504	Zn-dependent protease
DN409_RS06050	COG0180	Tryptophanyl-tRNA synthetase
DN409_RS06065	COG4166	transmembrane transport
DN409_RS06070	COG0601	transmembrane transport
DN409_RS06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN409_RS06080	COG0444	Belongs to the ABC transporter superfamily
DN409_RS06085	COG4608	Belongs to the ABC transporter superfamily
DN409_RS06090	COG0534	Mate efflux family protein
DN409_RS06095	COG4166	transmembrane transport
DN409_RS06115	COG0861	Integral membrane protein TerC family
DN409_RS06120	COG4862	establishment of competence for transformation
DN409_RS06125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN409_RS06135	COG1164	Oligoendopeptidase f
DN409_RS06145	COG2346	COG2346, Truncated hemoglobins
DN409_RS06150	COG4116	CYTH
DN409_RS06160	COG2357	RelA SpoT domain protein
DN409_RS06170	COG0564	pseudouridine synthase activity
DN409_RS06180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN409_RS06185	COG0772	Belongs to the SEDS family
DN409_RS06190	COG1216	Glycosyl transferase, family 2
DN409_RS06210	COG0463	Glycosyl transferase, family 2
DN409_RS06210	COG0457	Tetratricopeptide repeat
DN409_RS06230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DN409_RS06245	COG1091	dTDP-4-dehydrorhamnose reductase activity
DN409_RS06290	COG2153	protein acetylation
DN409_RS06295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DN409_RS06300	COG2382	esterase
DN409_RS06325	COG5492	domain, Protein
DN409_RS06330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN409_RS06345	COG0512	Glutamine amidotransferase of anthranilate synthase
DN409_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DN409_RS06350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DN409_RS06355	COG0134	indole-3-glycerol-phosphate synthase activity
DN409_RS06360	COG0135	phosphoribosylanthranilate isomerase activity
DN409_RS06365	COG0133	tryptophan synthase activity
DN409_RS06370	COG0159	tryptophan synthase activity
DN409_RS06380	COG1620	l-lactate permease
DN409_RS06385	COG5634	Uncharacterized conserved protein (DUF2278)
DN409_RS06435	COG2226	methyltransferase
DN409_RS06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN409_RS06460	COG0567	Dehydrogenase, E1 component
DN409_RS06465	COG1476	TRANSCRIPTIONal
DN409_RS06530	COG4974	Belongs to the 'phage' integrase family
DN409_RS06550	COG1686	Belongs to the peptidase S11 family
DN409_RS06555	COG0681	Belongs to the peptidase S26 family
DN409_RS06595	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS06605	COG1176	ABC-type spermidine putrescine transport system, permease component I
DN409_RS06610	COG1177	transmembrane transport
DN409_RS06615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DN409_RS06625	COG2409	Drug exporters of the RND superfamily
DN409_RS06635	COG0564	pseudouridine synthase activity
DN409_RS06645	COG2340	Cysteine-rich secretory protein family
DN409_RS06650	COG0247	lactate metabolic process
DN409_RS06655	COG0277	FAD linked oxidase domain protein
DN409_RS06660	COG3835	regulator
DN409_RS06670	COG0745	RESPONSE REGULATOR receiver
DN409_RS06675	COG5002	protein histidine kinase activity
DN409_RS06680	COG2186	Transcriptional regulator
DN409_RS06685	COG0247	lactate metabolic process
DN409_RS06690	COG1139	Iron-sulfur cluster binding protein
DN409_RS06695	COG1556	Lactate utilization protein
DN409_RS06700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DN409_RS06710	COG2116	formate transmembrane transporter activity
DN409_RS06715	COG0861	Integral membrane protein TerC family
DN409_RS06720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN409_RS06730	COG2030	dehydratase
DN409_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS06755	COG3243	poly(R)-hydroxyalkanoic acid synthase
DN409_RS06765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN409_RS06780	COG1840	ABC-type Fe3 transport system, periplasmic component
DN409_RS06785	COG3842	ATPase activity
DN409_RS06795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN409_RS06800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DN409_RS06810	COG1349	DNA-binding transcription factor activity
DN409_RS06820	COG0235	Class ii aldolase
DN409_RS06830	COG2861	carbohydrate metabolic process
DN409_RS06840	COG3852	Histidine kinase
DN409_RS06845	COG1846	Transcriptional regulator
DN409_RS06855	COG2318	DinB family
DN409_RS06860	COG5002	protein histidine kinase activity
DN409_RS06865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DN409_RS06870	COG0720	synthase
DN409_RS06880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DN409_RS06885	COG4873	Protein conserved in bacteria
DN409_RS06895	COG0456	acetyltransferase
DN409_RS06915	COG1780	Probably involved in ribonucleotide reductase function
DN409_RS06930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN409_RS06935	COG0531	amino acid
DN409_RS06940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN409_RS06955	COG2204	response regulator
DN409_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS06970	COG1725	Transcriptional regulator
DN409_RS06975	COG1131	(ABC) transporter
DN409_RS06985	COG1131	(ABC) transporter
DN409_RS06990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DN409_RS06995	COG1266	CAAX protease self-immunity
DN409_RS07005	COG1522	sequence-specific DNA binding
DN409_RS07015	COG1335	isochorismatase
DN409_RS07025	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN409_RS07030	COG2070	2-Nitropropane dioxygenase
DN409_RS07035	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DN409_RS07040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN409_RS07045	COG1696	Membrane protein involved in D-alanine export
DN409_RS07050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN409_RS07065	COG0716	FMN binding
DN409_RS07090	COG0534	Mate efflux family protein
DN409_RS07110	COG1846	Transcriptional regulator
DN409_RS07120	COG1301	dicarboxylic acid transport
DN409_RS07125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN409_RS07135	COG3874	Sporulation protein YtfJ
DN409_RS07155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN409_RS07160	COG0028	Belongs to the TPP enzyme family
DN409_RS07165	COG0440	acetolactate synthase activity
DN409_RS07175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN409_RS07185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DN409_RS07195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DN409_RS07200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DN409_RS07210	COG0131	Imidazoleglycerol-phosphate dehydratase
DN409_RS07215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DN409_RS07220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DN409_RS07225	COG0107	imidazoleglycerol-phosphate synthase activity
DN409_RS07235	COG0140	phosphoribosyl-ATP diphosphatase activity
DN409_RS07240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN409_RS07255	COG1183	phosphatidylcholine synthase activity
DN409_RS07260	COG1368	sulfuric ester hydrolase activity
DN409_RS07270	COG0019	diaminopimelate decarboxylase activity
DN409_RS07280	COG0175	sulfate reduction
DN409_RS07285	COG2046	Belongs to the sulfate adenylyltransferase family
DN409_RS07290	COG0529	Catalyzes the synthesis of activated sulfate
DN409_RS07295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN409_RS07315	COG1648	precorrin-2 dehydrogenase activity
DN409_RS07320	COG0733	neurotransmitter:sodium symporter activity
DN409_RS07340	COG1757	Na H antiporter
DN409_RS07360	COG4758	membrane
DN409_RS07365	COG4585	Histidine kinase
DN409_RS07370	COG2197	response regulator
DN409_RS07380	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS07390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DN409_RS07435	COG0730	response to heat
DN409_RS07440	COG0306	phosphate transporter
DN409_RS07445	COG1392	Phosphate transport regulator
DN409_RS07450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN409_RS07465	COG3852	Histidine kinase
DN409_RS07470	COG1801	Protein of unknown function DUF72
DN409_RS07480	COG0582	viral genome integration into host DNA
DN409_RS07485	COG5002	protein histidine kinase activity
DN409_RS07500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DN409_RS07500	COG0392	lysyltransferase activity
DN409_RS07515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN409_RS07520	COG1686	Belongs to the peptidase S11 family
DN409_RS07525	COG2715	membrane protein required for spore maturation
DN409_RS07530	COG0700	Nucleoside recognition
DN409_RS07535	COG1187	pseudouridine synthase activity
DN409_RS07545	COG1333	cytochrome c biogenesis protein
DN409_RS07550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DN409_RS07555	COG0745	RESPONSE REGULATOR receiver
DN409_RS07560	COG5002	protein histidine kinase activity
DN409_RS07565	COG2096	Adenosyltransferase
DN409_RS07570	COG4942	peptidase
DN409_RS07580	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DN409_RS07585	COG1141	Ferredoxin
DN409_RS07595	COG4955	Helix-turn-helix domain
DN409_RS07600	COG0514	ATP-dependent DNA helicase (RecQ)
DN409_RS07605	COG1266	CAAX protease self-immunity
DN409_RS07615	COG1408	metallophosphoesterase
DN409_RS07630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN409_RS07650	COG0492	ferredoxin-NADP+ reductase activity
DN409_RS07655	COG0252	asparaginase activity
DN409_RS07660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DN409_RS07670	COG1304	FMN binding
DN409_RS07700	COG1160	GTP binding
DN409_RS07705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DN409_RS07725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN409_RS07735	COG0302	gtp cyclohydrolase
DN409_RS07740	COG0142	geranyltranstransferase activity
DN409_RS07745	COG2226	methyltransferase
DN409_RS07750	COG0142	geranyltranstransferase activity
DN409_RS07765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DN409_RS07775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DN409_RS07780	COG0457	Tetratricopeptide repeat
DN409_RS07785	COG5582	Belongs to the UPF0302 family
DN409_RS07800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN409_RS07815	COG4347	Protein of unknown function (DUF1405)
DN409_RS07830	COG2738	Putative neutral zinc metallopeptidase
DN409_RS07840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS07845	COG1694	Mazg nucleotide pyrophosphohydrolase
DN409_RS07850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DN409_RS07855	COG1803	Methylglyoxal synthase
DN409_RS07860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN409_RS07865	COG0438	transferase activity, transferring glycosyl groups
DN409_RS07870	COG0617	tRNA 3'-terminal CCA addition
DN409_RS07880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DN409_RS07885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DN409_RS07895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DN409_RS07895	COG1199	ATP-dependent helicase activity
DN409_RS07915	COG3935	DnaD domain protein
DN409_RS07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DN409_RS07930	COG4499	WXG100 protein secretion system (Wss), protein YukC
DN409_RS07930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN409_RS07935	COG3331	DNA recombination
DN409_RS07970	COG4474	Belongs to the UPF0398 family
DN409_RS07975	COG3599	regulation of cell shape
DN409_RS07985	COG0116	Belongs to the methyltransferase superfamily
DN409_RS07995	COG1199	ATP-dependent helicase activity
DN409_RS08000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DN409_RS08010	COG0024	Methionine aminopeptidase
DN409_RS08025	COG2233	PERMEase
DN409_RS08030	COG2311	Membrane
DN409_RS08035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN409_RS08045	COG0456	acetyltransferase
DN409_RS08055	COG2897	thiosulfate sulfurtransferase activity
DN409_RS08095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN409_RS08110	COG0454	-acetyltransferase
DN409_RS08130	COG0328	RNA-DNA hybrid ribonuclease activity
DN409_RS08165	COG3403	YqcI/YcgG family
DN409_RS08170	COG1280	lysine exporter protein (LysE YggA)
DN409_RS08185	COG3162	membrane
DN409_RS08190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN409_RS08195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN409_RS08205	COG0475	glutathione-regulated potassium exporter activity
DN409_RS08210	COG4978	Transcriptional regulator
DN409_RS08210	COG0789	Transcriptional regulator
DN409_RS08220	COG2323	membrane
DN409_RS08225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DN409_RS08285	COG1923	regulation of RNA biosynthetic process
DN409_RS08295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DN409_RS08300	COG1360	Flagellar Motor Protein
DN409_RS08305	COG2201	protein-glutamate methylesterase activity
DN409_RS08310	COG2198	Histidine kinase
DN409_RS08310	COG0643	Histidine kinase
DN409_RS08315	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN409_RS08315	COG1776	CheC inhibitor of MCP methylation
DN409_RS08330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DN409_RS08350	COG1256	bacterial-type flagellum assembly
DN409_RS08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN409_RS08380	COG1815	bacterial-type flagellum-dependent cell motility
DN409_RS08385	COG1558	bacterial-type flagellum-dependent cell motility
DN409_RS08395	COG1766	The M ring may be actively involved in energy transduction
DN409_RS08400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN409_RS08410	COG1157	protein secretion by the type III secretion system
DN409_RS08430	COG1749	Flagellar hook protein flgE
DN409_RS08445	COG0835	chemotaxis
DN409_RS08445	COG0784	Response regulator, receiver
DN409_RS08465	COG0861	Integral membrane protein TerC family
DN409_RS08475	COG3383	formate dehydrogenase (NAD+) activity
DN409_RS08480	COG2427	Protein of unknown function (DUF1641)
DN409_RS08485	COG5609	conserved protein (DUF2294)
DN409_RS08490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN409_RS08500	COG2116	formate transmembrane transporter activity
DN409_RS08505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN409_RS08510	COG0303	'Molybdopterin
DN409_RS08515	COG0314	molybdopterin synthase activity
DN409_RS08520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DN409_RS08530	COG0489	protein tyrosine kinase activity
DN409_RS08535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN409_RS08540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN409_RS08545	COG0741	lytic transglycosylase activity
DN409_RS08555	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN409_RS08560	COG1776	CheC inhibitor of MCP methylation
DN409_RS08560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN409_RS08570	COG1338	Plays a role in the flagellum-specific transport system
DN409_RS08575	COG1987	bacterial-type flagellum assembly
DN409_RS08585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DN409_RS08590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DN409_RS08595	COG1419	protein localization to endoplasmic reticulum
DN409_RS08600	COG4786	Flagellar basal body rod
DN409_RS08605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN409_RS08635	COG2329	Antibiotic biosynthesis monooxygenase
DN409_RS08650	COG2814	Major facilitator Superfamily
DN409_RS08660	COG0583	DNA-binding transcription factor activity
DN409_RS08665	COG3842	ATPase activity
DN409_RS08745	COG0367	asparagine synthase
DN409_RS08775	COG1802	Transcriptional regulator
DN409_RS08780	COG0697	spore germination
DN409_RS08785	COG1216	Glycosyl transferase, family 2
DN409_RS08785	COG0438	transferase activity, transferring glycosyl groups
DN409_RS08790	COG1757	Na H antiporter
DN409_RS08830	COG0534	Mate efflux family protein
DN409_RS08835	COG3340	Belongs to the peptidase S51 family
DN409_RS08855	COG0785	Cytochrome C biogenesis protein
DN409_RS08860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS08875	COG3048	D-serine ammonia-lyase activity
DN409_RS08880	COG2733	membrane
DN409_RS08920	COG1131	(ABC) transporter
DN409_RS08940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN409_RS08945	COG0528	UMP kinase activity
DN409_RS08955	COG1027	Aspartate ammonia-lyase
DN409_RS08960	COG0281	malic enzyme
DN409_RS08965	COG4191	Histidine kinase
DN409_RS08970	COG0784	Response regulator, receiver
DN409_RS08975	COG1846	Transcriptional regulator
DN409_RS08985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN409_RS08995	COG2502	aspartate--ammonia ligase
DN409_RS09000	COG3620	sequence-specific DNA binding
DN409_RS09035	COG1051	belongs to the nudix hydrolase family
DN409_RS09050	COG2814	Major facilitator Superfamily
DN409_RS09080	COG0477	Major facilitator Superfamily
DN409_RS09100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN409_RS09105	COG2223	nitrite transmembrane transporter activity
DN409_RS09110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN409_RS09125	COG2244	polysaccharide biosynthetic process
DN409_RS09130	COG0733	neurotransmitter:sodium symporter activity
DN409_RS09140	COG5566	PFAM Mor transcription activator
DN409_RS09145	COG2323	membrane
DN409_RS09165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN409_RS09170	COG2132	Multicopper oxidase
DN409_RS09180	COG5002	protein histidine kinase activity
DN409_RS09185	COG0745	RESPONSE REGULATOR receiver
DN409_RS09195	COG0129	dihydroxy-acid dehydratase activity
DN409_RS09200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN409_RS09225	COG2814	Major facilitator Superfamily
DN409_RS09230	COG3384	dioxygenase
DN409_RS09285	COG4166	transmembrane transport
DN409_RS09320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS09340	COG1914	H( )-stimulated, divalent metal cation uptake system
DN409_RS09345	COG1054	Belongs to the UPF0176 family
DN409_RS09355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN409_RS09360	COG0531	amino acid
DN409_RS09395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN409_RS09410	COG4257	antibiotic catabolic process
DN409_RS09415	COG2390	Transcriptional regulator
DN409_RS09425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DN409_RS09430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS09435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DN409_RS09450	COG4846	Membrane protein involved in cytochrome C biogenesis
DN409_RS09470	COG0583	DNA-binding transcription factor activity
DN409_RS09490	COG0006	proline dipeptidase activity
DN409_RS09495	COG2132	Multicopper oxidase
DN409_RS09510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN409_RS09520	COG0583	DNA-binding transcription factor activity
DN409_RS09540	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS09550	COG1834	amidinotransferase
DN409_RS09560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS09605	COG2372	response to copper ion
DN409_RS09605	COG1276	copper resistance
DN409_RS09610	COG4549	nuclear export factor GLE1
DN409_RS09620	COG0697	spore germination
DN409_RS09625	COG0583	DNA-binding transcription factor activity
DN409_RS09630	COG1959	2 iron, 2 sulfur cluster binding
DN409_RS09635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DN409_RS09640	COG0778	Nitroreductase
DN409_RS09655	COG0628	permease
DN409_RS09670	COG1231	oxidoreductase activity
DN409_RS09675	COG0523	cobalamin synthesis protein
DN409_RS09685	COG0411	ABC transporter
DN409_RS09705	COG0583	DNA-binding transcription factor activity
DN409_RS09715	COG1942	4-Oxalocrotonate Tautomerase
DN409_RS09730	COG0346	lactoylglutathione lyase activity
DN409_RS09740	COG1271	oxidase subunit
DN409_RS09745	COG1294	oxidase, subunit
DN409_RS09750	COG4988	ABC transporter
DN409_RS09755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DN409_RS09785	COG1686	Belongs to the peptidase S11 family
DN409_RS09800	COG1388	LysM domain
DN409_RS09800	COG0791	NLP P60 protein
DN409_RS09810	COG1132	(ABC) transporter
DN409_RS09815	COG0745	RESPONSE REGULATOR receiver
DN409_RS09820	COG5002	protein histidine kinase activity
DN409_RS09825	COG0300	oxidoreductase activity
DN409_RS09830	COG4122	O-methyltransferase activity
DN409_RS09845	COG5658	integral membrane protein
DN409_RS09865	COG0460	homoserine dehydrogenase
DN409_RS09875	COG0083	homoserine kinase activity
DN409_RS09890	COG1316	TRANSCRIPTIONal
DN409_RS09900	COG0745	RESPONSE REGULATOR receiver
DN409_RS09905	COG5002	protein histidine kinase activity
DN409_RS09930	COG1285	pathogenesis
DN409_RS09935	COG1247	-acetyltransferase
DN409_RS09955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN409_RS09965	COG1082	Xylose isomerase domain protein TIM barrel
DN409_RS09975	COG2814	Major facilitator Superfamily
DN409_RS09980	COG1279	arginine transmembrane transporter activity
DN409_RS09985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS09995	COG1752	Esterase of the alpha-beta hydrolase superfamily
DN409_RS10025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DN409_RS10030	COG0577	efflux transmembrane transporter activity
DN409_RS10035	COG2002	toxin-antitoxin pair type II binding
DN409_RS10040	COG1404	Belongs to the peptidase S8 family
DN409_RS10050	COG3842	ATPase activity
DN409_RS10055	COG2508	Transcriptional regulator
DN409_RS10065	COG1653	transport
DN409_RS10070	COG1175	transmembrane transport
DN409_RS10075	COG0395	ABC-type sugar transport system, permease component
DN409_RS10080	COG5426	von Willebrand factor, type A
DN409_RS10085	COG1940	carbohydrate kinase activity
DN409_RS10090	COG2222	sugar isomerase
DN409_RS10100	COG1105	Belongs to the carbohydrate kinase PfkB family
DN409_RS10105	COG3684	Belongs to the aldolase LacD family
DN409_RS10110	COG0366	Alpha amylase catalytic
DN409_RS10120	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DN409_RS10125	COG0640	Transcriptional regulator
DN409_RS10130	COG0667	Aldo Keto reductase
DN409_RS10135	COG2814	Major facilitator Superfamily
DN409_RS10180	COG3949	Membrane
DN409_RS10185	COG0783	Belongs to the Dps family
DN409_RS10200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN409_RS10210	COG1231	oxidoreductase activity
DN409_RS10215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS10220	COG4989	oxidoreductase activity
DN409_RS10225	COG0523	cobalamin synthesis protein
DN409_RS10230	COG0456	acetyltransferase
DN409_RS10235	COG0803	Belongs to the bacterial solute-binding protein 9 family
DN409_RS10250	COG1902	pentaerythritol trinitrate reductase activity
DN409_RS10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN409_RS10265	COG4166	transmembrane transport
DN409_RS10270	COG0346	lactoylglutathione lyase activity
DN409_RS10280	COG0406	alpha-ribazole phosphatase activity
DN409_RS10290	COG5337	Spore coat protein CotH
DN409_RS10295	COG1051	belongs to the nudix hydrolase family
DN409_RS10300	COG0586	Pfam SNARE associated Golgi protein
DN409_RS10305	COG2244	polysaccharide biosynthetic process
DN409_RS10315	COG0701	Predicted permease
DN409_RS10320	COG3689	TIGRFAM TIGR03943 family protein
DN409_RS10325	COG1607	acyl-coa hydrolase
DN409_RS10335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN409_RS10350	COG0702	epimerase
DN409_RS10355	COG2839	Protein conserved in bacteria
DN409_RS10360	COG1253	flavin adenine dinucleotide binding
DN409_RS10385	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS10390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN409_RS10410	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS10425	COG1876	peptidase activity
DN409_RS10430	COG0494	nUDIX hydrolase
DN409_RS10455	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS10465	COG0561	phosphatase activity
DN409_RS10470	COG1846	Transcriptional regulator
DN409_RS10475	COG2814	Major facilitator Superfamily
DN409_RS10485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN409_RS10490	COG4106	trans-aconitate 2-methyltransferase activity
DN409_RS10505	COG1819	glycosyl
DN409_RS10510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS10515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS10540	COG0456	acetyltransferase
DN409_RS10560	COG3874	Sporulation protein YtfJ
DN409_RS10585	COG2226	methyltransferase
DN409_RS10615	COG0604	alcohol dehydrogenase
DN409_RS10620	COG1595	DNA-templated transcription, initiation
DN409_RS10645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DN409_RS10645	COG0426	domain, Protein
DN409_RS10655	COG0386	Belongs to the glutathione peroxidase family
DN409_RS10660	COG1305	Transglutaminase-like
DN409_RS10665	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DN409_RS10670	COG0714	Associated with various cellular activities
DN409_RS10675	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DN409_RS10680	COG1140	nitrate reductase beta subunit
DN409_RS10685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DN409_RS10690	COG2181	nitrate reductase activity
DN409_RS10695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN409_RS10700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN409_RS10705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN409_RS10710	COG0303	'Molybdopterin
DN409_RS10715	COG0314	molybdopterin synthase activity
DN409_RS10725	COG2223	nitrite transmembrane transporter activity
DN409_RS10745	COG1648	precorrin-2 dehydrogenase activity
DN409_RS10755	COG1587	Uroporphyrinogen-III synthase
DN409_RS10755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DN409_RS10760	COG2146	nitrite reductase [NAD(P)H] activity
DN409_RS10765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN409_RS10770	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DN409_RS10795	COG2359	stage V sporulation protein S
DN409_RS10805	COG1418	mRNA catabolic process
DN409_RS10810	COG0488	(ABC) transporter
DN409_RS10840	COG1413	lyase activity
DN409_RS10855	COG2521	methyltransferase
DN409_RS10855	COG2136	Putative SAM-dependent methyltransferase
DN409_RS10860	COG0018	arginyl-trna synthetase
DN409_RS10910	COG0017	Asparaginyl-tRNA synthetase
DN409_RS10930	COG1674	ftsk spoiiie
DN409_RS10955	COG5444	nuclease activity
DN409_RS10975	COG0733	neurotransmitter:sodium symporter activity
DN409_RS11005	COG2610	gluconate transmembrane transporter activity
DN409_RS11015	COG1794	racemase activity, acting on amino acids and derivatives
DN409_RS11025	COG0456	acetyltransferase
DN409_RS11030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DN409_RS11035	COG1131	(ABC) transporter
DN409_RS11040	COG4473	ABC transporter
DN409_RS11050	COG0546	phosphoglycolate phosphatase activity
DN409_RS11105	COG0768	penicillin binding
DN409_RS11120	COG1272	protein, Hemolysin III
DN409_RS11125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN409_RS11130	COG0805	protein transport
DN409_RS11140	COG1307	EDD domain protein, DegV family
DN409_RS11145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DN409_RS11150	COG1999	signal sequence binding
DN409_RS11155	COG0071	Belongs to the small heat shock protein (HSP20) family
DN409_RS11160	COG0367	asparagine synthase
DN409_RS11175	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN409_RS11180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS11185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN409_RS11230	COG2211	Major facilitator Superfamily
DN409_RS11255	COG1335	isochorismatase
DN409_RS11265	COG0668	transmembrane transport
DN409_RS11270	COG4585	Histidine kinase
DN409_RS11270	COG2203	Gaf domain
DN409_RS11275	COG2197	response regulator
DN409_RS11280	COG1737	Transcriptional regulator
DN409_RS11285	COG1064	alcohol dehydrogenase
DN409_RS11300	COG1070	Carbohydrate kinase
DN409_RS11310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN409_RS11330	COG1125	glycine betaine transport
DN409_RS11330	COG0517	IMP dehydrogenase activity
DN409_RS11335	COG1174	glycine betaine transport
DN409_RS11370	COG1253	flavin adenine dinucleotide binding
DN409_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS11380	COG5506	Protein of unknown function (DUF1694)
DN409_RS11395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN409_RS11400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DN409_RS11405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DN409_RS11410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN409_RS11415	COG0456	acetyltransferase
DN409_RS11420	COG3829	transcription factor binding
DN409_RS11425	COG1509	lysine 2,3-aminomutase activity
DN409_RS11435	COG4479	Belongs to the UPF0346 family
DN409_RS11460	COG4991	sh3 domain protein
DN409_RS11460	COG0515	serine threonine protein kinase
DN409_RS11460	COG3064	Membrane
DN409_RS11470	COG0671	phosphoesterase, PA-phosphatase related
DN409_RS11475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DN409_RS11480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS11555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DN409_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS11600	COG4499	WXG100 protein secretion system (Wss), protein YukC
DN409_RS11600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN409_RS11610	COG2814	Major facilitator Superfamily
DN409_RS11620	COG0372	Belongs to the citrate synthase family
DN409_RS11625	COG2079	MmgE PrpD family protein
DN409_RS11630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DN409_RS11635	COG1960	acyl-CoA dehydrogenase activity
DN409_RS11640	COG2084	Dehydrogenase
DN409_RS11645	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS11650	COG1280	lysine exporter protein (LysE YggA)
DN409_RS11655	COG1024	Enoyl-CoA hydratase
DN409_RS11670	COG0420	3'-5' exonuclease activity
DN409_RS11690	COG2223	nitrite transmembrane transporter activity
DN409_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS11700	COG1169	isochorismate synthase
DN409_RS11705	COG1021	2,3-dihydroxybenzoate-AMP ligase
DN409_RS11710	COG3433	isochorismatase activity
DN409_RS11710	COG1535	isochorismatase
DN409_RS11715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN409_RS11720	COG3251	PFAM MbtH domain protein
DN409_RS11725	COG2814	Major facilitator Superfamily
DN409_RS11740	COG0776	regulation of translation
DN409_RS11750	COG2318	DinB family
DN409_RS11755	COG1115	amino acid carrier protein
DN409_RS11770	COG2329	Antibiotic biosynthesis monooxygenase
DN409_RS11785	COG1187	pseudouridine synthase activity
DN409_RS11790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN409_RS11795	COG3655	Transcriptional regulator
DN409_RS11805	COG1136	(ABC) transporter
DN409_RS11815	COG2814	Major facilitator Superfamily
DN409_RS11830	COG0028	Belongs to the TPP enzyme family
DN409_RS11855	COG1253	flavin adenine dinucleotide binding
DN409_RS11890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN409_RS11910	COG1846	Transcriptional regulator
DN409_RS11925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS11930	COG1309	transcriptional regulator
DN409_RS11960	COG1247	-acetyltransferase
DN409_RS12000	COG0596	Alpha beta hydrolase
DN409_RS12005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DN409_RS12015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS12045	COG0583	DNA-binding transcription factor activity
DN409_RS12050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DN409_RS12110	COG0583	DNA-binding transcription factor activity
DN409_RS12115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN409_RS12120	COG2258	MOSC domain
DN409_RS12135	COG1132	(ABC) transporter
DN409_RS12140	COG1132	(ABC) transporter
DN409_RS12160	COG1396	sequence-specific DNA binding
DN409_RS12265	COG1278	Cold shock
DN409_RS12300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN409_RS12310	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DN409_RS12315	COG1595	DNA-templated transcription, initiation
DN409_RS12335	COG1649	PFAM Uncharacterised BCR, COG1649
DN409_RS12355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DN409_RS12360	COG2971	BadF BadG BcrA BcrD
DN409_RS12370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DN409_RS12425	COG0500	methyltransferase
DN409_RS12425	COG3615	Tellurite resistance protein tehB
DN409_RS12435	COG0693	protein deglycase activity
DN409_RS12445	COG0588	phosphoglycerate mutase activity
DN409_RS12485	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN409_RS12490	COG0110	maltose O-acetyltransferase activity
DN409_RS12505	COG1136	(ABC) transporter
DN409_RS12535	COG1136	(ABC) transporter
DN409_RS12540	COG0577	efflux transmembrane transporter activity
DN409_RS12555	COG5002	protein histidine kinase activity
DN409_RS12565	COG1686	Belongs to the peptidase S11 family
DN409_RS12595	COG0768	penicillin binding
DN409_RS12600	COG0745	RESPONSE REGULATOR receiver
DN409_RS12605	COG2205	protein histidine kinase activity
DN409_RS12610	COG1136	(ABC) transporter
DN409_RS12615	COG0577	efflux transmembrane transporter activity
DN409_RS12625	COG1595	DNA-templated transcription, initiation
DN409_RS12635	COG0768	penicillin binding
DN409_RS12640	COG0768	penicillin binding
DN409_RS12675	COG1252	NADH dehydrogenase
DN409_RS12680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS12680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS12695	COG0697	spore germination
DN409_RS12725	COG3397	chitin binding
DN409_RS12730	COG0823	Involved in the tonB-independent uptake of proteins
DN409_RS12740	COG1408	metallophosphoesterase
DN409_RS12750	COG1131	(ABC) transporter
DN409_RS12760	COG1309	transcriptional regulator
DN409_RS12770	COG1960	acyl-CoA dehydrogenase activity
DN409_RS12775	COG0439	Biotin carboxylase
DN409_RS12780	COG0511	ligase activity, forming carbon-carbon bonds
DN409_RS12785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN409_RS12790	COG1024	Enoyl-CoA hydratase
DN409_RS12795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN409_RS12800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN409_RS12840	COG0572	uridine kinase
DN409_RS12845	COG2318	DinB family
DN409_RS12875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN409_RS12900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN409_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS12930	COG1733	regulation of RNA biosynthetic process
DN409_RS12955	COG1309	transcriptional regulator
DN409_RS12970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS12985	COG0697	spore germination
DN409_RS12990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS13015	COG1063	alcohol dehydrogenase
DN409_RS13025	COG2323	membrane
DN409_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS13045	COG0697	spore germination
DN409_RS13065	COG0201	protein transport
DN409_RS13075	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS13080	COG3227	Zinc metalloprotease (Elastase)
DN409_RS13085	COG1523	belongs to the glycosyl hydrolase 13 family
DN409_RS13100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS13105	COG1073	alpha beta
DN409_RS13115	COG0577	efflux transmembrane transporter activity
DN409_RS13120	COG1136	(ABC) transporter
DN409_RS13150	COG5002	protein histidine kinase activity
DN409_RS13155	COG0745	RESPONSE REGULATOR receiver
DN409_RS13160	COG1011	Hydrolase
DN409_RS13185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN409_RS13190	COG1183	phosphatidylcholine synthase activity
DN409_RS13205	COG1132	(ABC) transporter
DN409_RS13215	COG3961	Belongs to the TPP enzyme family
DN409_RS13235	COG0322	excinuclease ABC activity
DN409_RS13260	COG2318	DinB family
DN409_RS13275	COG4667	esterase of the alpha-beta hydrolase superfamily
DN409_RS13300	COG3878	Protein conserved in bacteria
DN409_RS13325	COG1051	belongs to the nudix hydrolase family
DN409_RS13330	COG0592	DNA-directed DNA polymerase activity
DN409_RS13335	COG2816	NAD+ diphosphatase activity
DN409_RS13345	COG2223	nitrite transmembrane transporter activity
DN409_RS13350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS13360	COG0494	nUDIX hydrolase
DN409_RS13380	COG0697	spore germination
DN409_RS13395	COG0584	glycerophosphoryl diester phosphodiesterase
DN409_RS13410	COG1733	regulation of RNA biosynthetic process
DN409_RS13420	COG2814	Major facilitator Superfamily
DN409_RS13440	COG1132	(ABC) transporter
DN409_RS13470	COG0768	penicillin binding
DN409_RS13475	COG0671	phosphoesterase, PA-phosphatase related
DN409_RS13480	COG0604	alcohol dehydrogenase
DN409_RS13485	COG5002	protein histidine kinase activity
DN409_RS13490	COG0745	RESPONSE REGULATOR receiver
DN409_RS13500	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN409_RS13510	COG2205	protein histidine kinase activity
DN409_RS13525	COG1122	ATPase activity
DN409_RS13530	COG4720	Psort location CytoplasmicMembrane, score
DN409_RS13535	COG1794	racemase activity, acting on amino acids and derivatives
DN409_RS13540	COG1819	glycosyl
DN409_RS13550	COG0768	penicillin binding
DN409_RS13555	COG5002	protein histidine kinase activity
DN409_RS13560	COG0561	phosphatase activity
DN409_RS13610	COG2124	cytochrome p450
DN409_RS13660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DN409_RS13670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS13675	COG0460	homoserine dehydrogenase
DN409_RS13695	COG0577	efflux transmembrane transporter activity
DN409_RS13700	COG1136	(ABC) transporter
DN409_RS13710	COG2211	Major facilitator Superfamily
DN409_RS13735	COG0488	(ABC) transporter
DN409_RS13740	COG0667	Aldo Keto reductase
DN409_RS13745	COG0583	DNA-binding transcription factor activity
DN409_RS13770	COG2205	protein histidine kinase activity
DN409_RS13775	COG0745	RESPONSE REGULATOR receiver
DN409_RS13785	COG3773	Cell wall hydrolase
DN409_RS13790	COG0604	alcohol dehydrogenase
DN409_RS13820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS13835	COG2959	enzyme of heme biosynthesis
DN409_RS13865	COG3483	tryptophan 2,3-dioxygenase activity
DN409_RS13870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DN409_RS13875	COG3844	kynureninase activity
DN409_RS13880	COG1309	transcriptional regulator
DN409_RS13895	COG3284	Transcriptional regulator
DN409_RS13910	COG1349	DNA-binding transcription factor activity
DN409_RS13930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN409_RS13935	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN409_RS13940	COG0022	dehydrogenase e1 component
DN409_RS13945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN409_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS13970	COG0456	acetyltransferase
DN409_RS13970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN409_RS14005	COG4176	ABC-type proline glycine betaine transport system permease component
DN409_RS14010	COG0517	IMP dehydrogenase activity
DN409_RS14010	COG4175	Glycine betaine
DN409_RS14035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DN409_RS14040	COG2153	protein acetylation
DN409_RS14045	COG3397	chitin binding
DN409_RS14055	COG1819	glycosyl
DN409_RS14070	COG2205	protein histidine kinase activity
DN409_RS14075	COG2315	Protein conserved in bacteria
DN409_RS14130	COG3973	AAA domain
DN409_RS14145	COG2105	PFAM AIG2 family protein
DN409_RS14150	COG0514	ATP-dependent DNA helicase (RecQ)
DN409_RS14170	COG4637	Psort location Cytoplasmic, score
DN409_RS14185	COG1227	inorganic diphosphatase activity
DN409_RS14190	COG3397	chitin binding
DN409_RS14195	COG2318	DinB family
DN409_RS14215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN409_RS14220	COG1115	amino acid carrier protein
DN409_RS14225	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS14230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN409_RS14240	COG3938	Belongs to the proline racemase family
DN409_RS14245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN409_RS14285	COG0586	Pfam SNARE associated Golgi protein
DN409_RS14300	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DN409_RS14305	COG4166	transmembrane transport
DN409_RS14315	COG4948	Mandelate Racemase Muconate Lactonizing
DN409_RS14335	COG0667	Aldo Keto reductase
DN409_RS14375	COG2936	dipeptidyl-peptidase activity
DN409_RS14385	COG0745	RESPONSE REGULATOR receiver
DN409_RS14405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN409_RS14410	COG1164	Oligoendopeptidase f
DN409_RS14425	COG1307	EDD domain protein, DegV family
DN409_RS14455	COG1335	isochorismatase
DN409_RS14470	COG2814	Major facilitator Superfamily
DN409_RS14480	COG1664	Polymer-forming cytoskeletal
DN409_RS14485	COG0789	Transcriptional regulator
DN409_RS14490	COG4533	DNA binding
DN409_RS14495	COG0477	Major facilitator Superfamily
DN409_RS14495	COG2814	Major facilitator Superfamily
DN409_RS14510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN409_RS14515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DN409_RS14520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN409_RS14525	COG0438	transferase activity, transferring glycosyl groups
DN409_RS14530	COG3328	transposase activity
DN409_RS14550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS14555	COG0438	transferase activity, transferring glycosyl groups
DN409_RS14560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS14575	COG2261	transglycosylase associated protein
DN409_RS14590	COG2226	methyltransferase
DN409_RS14625	COG0436	Aminotransferase
DN409_RS14630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DN409_RS14655	COG1131	(ABC) transporter
DN409_RS14660	COG2188	Transcriptional regulator
DN409_RS14705	COG0628	permease
DN409_RS14750	COG2746	aminoglycoside 3-N-acetyltransferase activity
DN409_RS14760	COG0697	spore germination
DN409_RS14785	COG4912	Dna alkylation repair
DN409_RS14810	COG2814	Major facilitator Superfamily
DN409_RS14815	COG1368	sulfuric ester hydrolase activity
DN409_RS14825	COG0488	(ABC) transporter
DN409_RS14830	COG2409	Drug exporters of the RND superfamily
DN409_RS14830	COG1033	growth of symbiont in host cell
DN409_RS14840	COG1309	transcriptional regulator
DN409_RS14865	COG0287	Prephenate dehydrogenase
DN409_RS14880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN409_RS14880	COG1605	Chorismate mutase
DN409_RS14910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DN409_RS14925	COG3584	3D domain protein
DN409_RS14925	COG1388	LysM domain
DN409_RS14935	COG0346	lactoylglutathione lyase activity
DN409_RS14945	COG0431	NADPH-dependent FMN reductase
DN409_RS14975	COG0579	oxidoreductase
DN409_RS14980	COG1879	ABC-type sugar transport system periplasmic component
DN409_RS14985	COG2390	Transcriptional regulator
DN409_RS15000	COG1830	Aldolase
DN409_RS15005	COG2226	methyltransferase
DN409_RS15020	COG0346	lactoylglutathione lyase activity
DN409_RS15025	COG2329	Antibiotic biosynthesis monooxygenase
DN409_RS15045	COG1472	Belongs to the glycosyl hydrolase 3 family
DN409_RS15050	COG2207	Transcriptional regulator
DN409_RS15075	COG2207	Transcriptional regulator
DN409_RS15095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS15100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DN409_RS15105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DN409_RS15110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN409_RS15115	COG3239	Fatty acid desaturase
DN409_RS15130	COG3655	Transcriptional regulator
DN409_RS15175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS15180	COG0346	lactoylglutathione lyase activity
DN409_RS15210	COG0714	Associated with various cellular activities
DN409_RS15230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN409_RS15235	COG0753	catalase activity
DN409_RS15245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DN409_RS15270	COG0714	Associated with various cellular activities
DN409_RS15280	COG0778	Nitroreductase
DN409_RS15285	COG1846	Transcriptional regulator
DN409_RS15325	COG1725	Transcriptional regulator
DN409_RS15355	COG2207	Transcriptional regulator
DN409_RS15360	COG0456	acetyltransferase
DN409_RS15375	COG0697	spore germination
DN409_RS15380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS15405	COG0456	acetyltransferase
DN409_RS15405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN409_RS15430	COG0730	response to heat
DN409_RS15440	COG0833	amino acid
DN409_RS15450	COG4335	DNA alkylation repair
DN409_RS15485	COG0768	penicillin binding
DN409_RS15500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DN409_RS15515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DN409_RS15520	COG1984	allophanate hydrolase subunit 2
DN409_RS15525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DN409_RS15530	COG1414	Transcriptional regulator
DN409_RS15550	COG1960	acyl-CoA dehydrogenase activity
DN409_RS15575	COG0640	Transcriptional regulator
DN409_RS15585	COG3314	Sporulation integral membrane protein YlbJ
DN409_RS15605	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DN409_RS15620	COG0574	Belongs to the PEP-utilizing enzyme family
DN409_RS15620	COG3848	Pyruvate phosphate dikinase
DN409_RS15630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN409_RS15640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS15670	COG1073	alpha beta
DN409_RS15695	COG5002	protein histidine kinase activity
DN409_RS15700	COG0745	RESPONSE REGULATOR receiver
DN409_RS15710	COG1575	Belongs to the MenA family. Type 1 subfamily
DN409_RS15720	COG3347	Dehydrogenase
DN409_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS15730	COG1070	Carbohydrate kinase
DN409_RS15735	COG0235	Class ii aldolase
DN409_RS15745	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN409_RS15755	COG4154	Belongs to the RbsD FucU family
DN409_RS15770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS15795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN409_RS15795	COG3320	Male sterility
DN409_RS15800	COG1309	transcriptional regulator
DN409_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS15810	COG1522	sequence-specific DNA binding
DN409_RS15825	COG0346	lactoylglutathione lyase activity
DN409_RS15855	COG2226	methyltransferase
DN409_RS15865	COG2814	Major facilitator Superfamily
DN409_RS15895	COG0745	RESPONSE REGULATOR receiver
DN409_RS15900	COG5002	protein histidine kinase activity
DN409_RS15900	COG3850	Histidine kinase
DN409_RS15930	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DN409_RS15945	COG2309	aminopeptidase activity
DN409_RS15955	COG1690	Belongs to the RtcB family
DN409_RS15970	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DN409_RS15990	COG1136	(ABC) transporter
DN409_RS15995	COG0577	efflux transmembrane transporter activity
DN409_RS16015	COG3850	Histidine kinase
DN409_RS16015	COG5002	protein histidine kinase activity
DN409_RS16025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS16040	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN409_RS16060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN409_RS16090	COG5444	nuclease activity
DN409_RS16140	COG2814	Major facilitator Superfamily
DN409_RS16175	COG0477	Major facilitator Superfamily
DN409_RS16190	COG1846	Transcriptional regulator
DN409_RS16195	COG2814	Major facilitator Superfamily
DN409_RS16225	COG0789	Transcriptional regulator
DN409_RS16260	COG1476	TRANSCRIPTIONal
DN409_RS16275	COG1288	antiporter activity
DN409_RS16280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DN409_RS16325	COG3718	enzyme involved in inositol metabolism
DN409_RS16330	COG0191	fructose-bisphosphate aldolase activity
DN409_RS16355	COG0673	inositol 2-dehydrogenase activity
DN409_RS16365	COG2814	Major facilitator Superfamily
DN409_RS16370	COG1609	Transcriptional regulator
DN409_RS16490	COG0419	ATPase involved in DNA repair
DN409_RS16560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN409_RS16620	COG0457	Tetratricopeptide repeat
DN409_RS16680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS16740	COG4187	Peptidase family M20/M25/M40
DN409_RS16760	COG2890	protein-(glutamine-N5) methyltransferase activity
DN409_RS16765	COG2031	fatty acid transporter
DN409_RS16775	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN409_RS16815	COG1122	ATPase activity
DN409_RS16835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DN409_RS16840	COG1288	antiporter activity
DN409_RS16845	COG2356	endonuclease I
DN409_RS16850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN409_RS16870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DN409_RS16890	COG1785	Belongs to the alkaline phosphatase family
DN409_RS16895	COG0778	Nitroreductase
DN409_RS16900	COG1733	regulation of RNA biosynthetic process
DN409_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS16925	COG1131	(ABC) transporter
DN409_RS16955	COG1595	DNA-templated transcription, initiation
DN409_RS16970	COG1011	Hydrolase
DN409_RS16975	COG2365	Tyrosine phosphatase family
DN409_RS16995	COG0346	lactoylglutathione lyase activity
DN409_RS17000	COG1940	carbohydrate kinase activity
DN409_RS17005	COG0738	Major facilitator superfamily
DN409_RS17010	COG0110	maltose O-acetyltransferase activity
DN409_RS17025	COG0628	permease
DN409_RS17030	COG2261	transglycosylase associated protein
DN409_RS17065	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DN409_RS17075	COG1253	flavin adenine dinucleotide binding
DN409_RS17080	COG0789	Transcriptional regulator
DN409_RS17085	COG0697	spore germination
DN409_RS17095	COG1357	PFAM Pentapeptide repeats (8 copies)
DN409_RS17100	COG3813	Protein conserved in bacteria
DN409_RS17105	COG2706	6-phosphogluconolactonase activity
DN409_RS17110	COG1070	Carbohydrate kinase
DN409_RS17120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN409_RS17125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DN409_RS17130	COG4702	Belongs to the UPF0303 family
DN409_RS17140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS17160	COG0384	phenazine biosynthesis protein PhzF
DN409_RS17180	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS17185	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN409_RS17190	COG1733	regulation of RNA biosynthetic process
DN409_RS17205	COG1191	sigma factor activity
DN409_RS17230	COG1876	peptidase activity
DN409_RS17270	COG0741	lytic transglycosylase activity
DN409_RS17305	COG0745	RESPONSE REGULATOR receiver
DN409_RS17330	COG2211	Major facilitator Superfamily
DN409_RS17340	COG0657	acetylesterase activity
DN409_RS17350	COG2814	Major facilitator Superfamily
DN409_RS17355	COG1309	transcriptional regulator
DN409_RS17375	COG2224	Isocitrate lyase
DN409_RS17405	COG0814	amino acid
DN409_RS17430	COG1151	hydroxylamine reductase activity
DN409_RS17460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS17470	COG2072	flavoprotein involved in K transport
DN409_RS17515	COG1695	Transcriptional regulator
DN409_RS17520	COG0604	alcohol dehydrogenase
DN409_RS17525	COG1113	amino acid transport
DN409_RS17535	COG2814	Major facilitator Superfamily
DN409_RS17550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN409_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS17565	COG0534	Mate efflux family protein
DN409_RS17570	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS17575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN409_RS17590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN409_RS17595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN409_RS17615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS17620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS17625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS17630	COG3739	integral membrane protein
DN409_RS17655	COG0583	DNA-binding transcription factor activity
DN409_RS17675	COG1193	negative regulation of DNA recombination
DN409_RS17695	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DN409_RS17700	COG1164	Oligoendopeptidase f
DN409_RS17705	COG2957	Belongs to the agmatine deiminase family
DN409_RS17725	COG3781	membrane
DN409_RS17740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS17775	COG3973	AAA domain
DN409_RS17785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DN409_RS17790	COG0640	Transcriptional regulator
DN409_RS17795	COG0604	alcohol dehydrogenase
DN409_RS17800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DN409_RS17810	COG0457	Tetratricopeptide repeat
DN409_RS17815	COG2808	Putative FMN-binding domain
DN409_RS17820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN409_RS17830	COG0277	FAD linked oxidase domain protein
DN409_RS17850	COG1285	pathogenesis
DN409_RS17860	COG2514	catechol 2,3-dioxygenase activity
DN409_RS17865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS17870	COG1126	abc transporter atp-binding protein
DN409_RS17875	COG0765	amino acid transport
DN409_RS17880	COG2720	vancomycin resistance protein
DN409_RS17905	COG1278	Cold shock
DN409_RS17915	COG0716	FMN binding
DN409_RS17945	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS17955	COG0165	Argininosuccinate lyase
DN409_RS17970	COG4145	pantothenate transmembrane transporter activity
DN409_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS17985	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS17995	COG1657	PFAM Prenyltransferase squalene oxidase
DN409_RS18000	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DN409_RS18005	COG2962	Rard protein
DN409_RS18010	COG3326	Membrane
DN409_RS18015	COG0531	amino acid
DN409_RS18045	COG2226	methyltransferase
DN409_RS18050	COG4166	transmembrane transport
DN409_RS18055	COG4166	transmembrane transport
DN409_RS18060	COG4166	transmembrane transport
DN409_RS18065	COG1316	TRANSCRIPTIONal
DN409_RS18075	COG1595	DNA-templated transcription, initiation
DN409_RS18085	COG1131	(ABC) transporter
DN409_RS18105	COG0673	inositol 2-dehydrogenase activity
DN409_RS18110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN409_RS18115	COG0187	DNA topoisomerase II activity
DN409_RS18120	COG1832	CoA-binding protein
DN409_RS18125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN409_RS18130	COG0745	RESPONSE REGULATOR receiver
DN409_RS18140	COG1328	CTP reductase activity
DN409_RS18140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN409_RS18150	COG4841	protein insertion into membrane
DN409_RS18155	COG0824	Thioesterase
DN409_RS18180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS18215	COG1132	(ABC) transporter
DN409_RS18220	COG1266	CAAX protease self-immunity
DN409_RS18225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DN409_RS18255	COG2211	Major facilitator Superfamily
DN409_RS18265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN409_RS18280	COG0183	Belongs to the thiolase family
DN409_RS18285	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS18290	COG1268	BioY protein
DN409_RS18295	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS18345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS18360	COG5002	protein histidine kinase activity
DN409_RS18370	COG0400	carboxylic ester hydrolase activity
DN409_RS18375	COG0346	lactoylglutathione lyase activity
DN409_RS18380	COG0069	glutamate synthase activity
DN409_RS18385	COG1902	pentaerythritol trinitrate reductase activity
DN409_RS18395	COG1329	Transcriptional regulator
DN409_RS18400	COG0010	Belongs to the arginase family
DN409_RS18410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DN409_RS18415	COG2986	histidine ammonia-lyase
DN409_RS18425	COG2226	methyltransferase
DN409_RS18455	COG4846	Membrane protein involved in cytochrome C biogenesis
DN409_RS18460	COG0785	Cytochrome C biogenesis protein
DN409_RS18475	COG1473	amidohydrolase
DN409_RS18480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DN409_RS18485	COG1131	(ABC) transporter
DN409_RS18495	COG0583	DNA-binding transcription factor activity
DN409_RS18505	COG1346	cytolysis
DN409_RS18520	COG0730	response to heat
DN409_RS18530	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN409_RS18530	COG3409	Peptidoglycan-binding domain 1 protein
DN409_RS18550	COG1132	(ABC) transporter
DN409_RS18555	COG1132	(ABC) transporter
DN409_RS18560	COG3763	UPF0154 protein
DN409_RS18580	COG3639	organic phosphonate transmembrane transporter activity
DN409_RS18590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS18595	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS18605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN409_RS18610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN409_RS18625	COG1695	Transcriptional regulator
DN409_RS18630	COG1132	(ABC) transporter
DN409_RS18665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DN409_RS18675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DN409_RS18685	COG3420	alginic acid biosynthetic process
DN409_RS18685	COG5434	Belongs to the glycosyl hydrolase 28 family
DN409_RS18695	COG1442	glycosyl transferase family 8
DN409_RS18700	COG1442	glycosyl transferase family 8
DN409_RS18700	COG1216	Glycosyl transferase, family 2
DN409_RS18715	COG0297	glycogen (starch) synthase activity
DN409_RS18725	COG0438	transferase activity, transferring glycosyl groups
DN409_RS18735	COG1215	transferase activity, transferring glycosyl groups
DN409_RS18740	COG0438	transferase activity, transferring glycosyl groups
DN409_RS18745	COG0438	transferase activity, transferring glycosyl groups
DN409_RS18750	COG1086	Polysaccharide biosynthesis protein
DN409_RS18755	COG0489	protein tyrosine kinase activity
DN409_RS18760	COG3944	biosynthesis protein
DN409_RS18765	COG0174	glutamine synthetase
DN409_RS18770	COG0789	Transcriptional regulator
DN409_RS18775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DN409_RS18780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN409_RS18785	COG2860	membrane
DN409_RS18790	COG0464	growth
DN409_RS18810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DN409_RS18820	COG1388	LysM domain
DN409_RS18820	COG3584	3D domain protein
DN409_RS18825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN409_RS18825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN409_RS18825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN409_RS18830	COG1105	Belongs to the carbohydrate kinase PfkB family
DN409_RS18835	COG1349	DNA-binding transcription factor activity
DN409_RS18840	COG1979	alcohol dehydrogenase
DN409_RS18845	COG2322	membrane
DN409_RS18855	COG1113	amino acid transport
DN409_RS18870	COG1473	amidohydrolase
DN409_RS18875	COG1408	metallophosphoesterase
DN409_RS18880	COG2116	formate transmembrane transporter activity
DN409_RS18895	COG2217	Heavy metal translocating P-type atpase
DN409_RS18900	COG2608	mercury ion transmembrane transporter activity
DN409_RS18905	COG1937	Protein conserved in bacteria
DN409_RS18925	COG2819	hydrolase of the alpha beta superfamily
DN409_RS18930	COG1120	ATPase activity
DN409_RS18935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS18940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS18945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS18950	COG0708	Exodeoxyribonuclease III
DN409_RS18955	COG2169	Transcriptional regulator
DN409_RS18960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN409_RS18965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DN409_RS18970	COG2706	6-phosphogluconolactonase activity
DN409_RS18975	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN409_RS18980	COG2364	Membrane
DN409_RS18990	COG0346	lactoylglutathione lyase activity
DN409_RS18995	COG3300	MHYT domain
DN409_RS18995	COG5001	Diguanylate cyclase
DN409_RS19035	COG1346	cytolysis
DN409_RS19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS19050	COG0596	Alpha beta hydrolase
DN409_RS19050	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN409_RS19055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN409_RS19070	COG2188	Transcriptional regulator
DN409_RS19075	COG2723	6-phospho-beta-galactosidase activity
DN409_RS19085	COG3773	Cell wall hydrolase
DN409_RS19095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN409_RS19105	COG2723	6-phospho-beta-galactosidase activity
DN409_RS19110	COG2190	(PTS) system
DN409_RS19110	COG1263	PTS System
DN409_RS19110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS19115	COG3711	transcriptional antiterminator
DN409_RS19125	COG0640	Transcriptional regulator
DN409_RS19130	COG0697	spore germination
DN409_RS19135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN409_RS19140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DN409_RS19145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DN409_RS19155	COG4550	Control of competence regulator ComK, YlbF/YmcA
DN409_RS19160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN409_RS19165	COG1013	pyruvate-flavodoxin oxidoreductase activity
DN409_RS19170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DN409_RS19170	COG0674	pyruvate-flavodoxin oxidoreductase activity
DN409_RS19180	COG2359	stage V sporulation protein S
DN409_RS19185	COG1692	metallophosphoesterase
DN409_RS19190	COG1418	mRNA catabolic process
DN409_RS19195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DN409_RS19200	COG1546	Belongs to the CinA family
DN409_RS19200	COG1058	Belongs to the CinA family
DN409_RS19205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DN409_RS19210	COG1426	Protein conserved in bacteria
DN409_RS19225	COG0300	oxidoreductase activity
DN409_RS19230	COG0612	Peptidase, M16
DN409_RS19235	COG0612	Peptidase, M16
DN409_RS19240	COG1079	Belongs to the binding-protein-dependent transport system permease family
DN409_RS19245	COG4603	Belongs to the binding-protein-dependent transport system permease family
DN409_RS19250	COG3845	ABC transporter
DN409_RS19255	COG1744	ABC transporter substrate-binding protein PnrA-like
DN409_RS19260	COG2188	Transcriptional regulator
DN409_RS19270	COG1674	ftsk spoiiie
DN409_RS19280	COG0740	serine-type endopeptidase activity
DN409_RS19285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN409_RS19295	COG0527	aspartate kinase activity
DN409_RS19300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DN409_RS19305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN409_RS19310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN409_RS19315	COG1873	PFAM PRC-barrel domain
DN409_RS19320	COG0612	Peptidase, M16
DN409_RS19325	COG0726	polysaccharide deacetylase
DN409_RS19330	COG1185	polyribonucleotide nucleotidyltransferase activity
DN409_RS19340	COG0196	riboflavin kinase activity
DN409_RS19350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DN409_RS19355	COG1550	Protein conserved in bacteria
DN409_RS19360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DN409_RS19365	COG1358	cellular component organization or biogenesis
DN409_RS19370	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DN409_RS19375	COG0195	Participates in both transcription termination and antitermination
DN409_RS19380	COG0779	Required for maturation of 30S ribosomal subunits
DN409_RS19390	COG0442	prolyl-tRNA aminoacylation
DN409_RS19395	COG0750	zinc metalloprotease
DN409_RS19405	COG4589	Belongs to the CDS family
DN409_RS19415	COG0233	cytoplasmic translational termination
DN409_RS19420	COG0528	UMP kinase activity
DN409_RS19425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DN409_RS19430	COG0052	Belongs to the universal ribosomal protein uS2 family
DN409_RS19435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DN409_RS19440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DN409_RS19445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DN409_RS19450	COG4974	Belongs to the 'phage' integrase family
DN409_RS19455	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DN409_RS19460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN409_RS19465	COG0758	DNA mediated transformation
DN409_RS19470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DN409_RS19475	COG0045	succinate-CoA ligase (ADP-forming) activity
DN409_RS19480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DN409_RS19495	COG0335	large ribosomal subunit rRNA binding
DN409_RS19500	COG0336	Belongs to the RNA methyltransferase TrmD family
DN409_RS19505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DN409_RS19510	COG1837	Belongs to the UPF0109 family
DN409_RS19520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DN409_RS19525	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DN409_RS19530	COG0552	protein localization to endoplasmic reticulum
DN409_RS19535	COG1196	nuclear chromosome segregation
DN409_RS19540	COG0571	ribonuclease III activity
DN409_RS19545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN409_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS19555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DN409_RS19560	COG0416	fatty acid biosynthetic process
DN409_RS19565	COG2050	protein possibly involved in aromatic compounds catabolism
DN409_RS19565	COG1349	DNA-binding transcription factor activity
DN409_RS19570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DN409_RS19575	COG1461	Dihydroxyacetone kinase
DN409_RS19580	COG1302	Protein conserved in bacteria
DN409_RS19595	COG1564	THIamine pyrophosphokinase
DN409_RS19600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DN409_RS19610	COG2815	serine threonine protein kinase
DN409_RS19610	COG0515	serine threonine protein kinase
DN409_RS19615	COG0631	protein serine/threonine phosphatase activity
DN409_RS19620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DN409_RS19625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DN409_RS19625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN409_RS19630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN409_RS19635	COG0242	peptide deformylase activity
DN409_RS19640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DN409_RS19645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN409_RS19650	COG1758	RNA polymerase activity
DN409_RS19665	COG1561	YicC-like family, N-terminal region
DN409_RS19670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN409_RS19685	COG0006	proline dipeptidase activity
DN409_RS19705	COG3069	C4-dicarboxylate transmembrane transporter activity
DN409_RS19725	COG0167	dihydroorotate dehydrogenase activity
DN409_RS19730	COG0543	2 iron, 2 sulfur cluster binding
DN409_RS19735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DN409_RS19745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN409_RS19750	COG0540	Belongs to the ATCase OTCase family
DN409_RS19760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DN409_RS19765	COG0564	pseudouridine synthase activity
DN409_RS19770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DN409_RS19780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DN409_RS19785	COG3599	regulation of cell shape
DN409_RS19790	COG2302	S4 RNA-binding domain
DN409_RS19795	COG0762	integral membrane protein
DN409_RS19800	COG1799	cell septum assembly
DN409_RS19805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DN409_RS19815	COG1873	PFAM PRC-barrel domain
DN409_RS19820	COG1191	sigma factor activity
DN409_RS19825	COG1191	sigma factor activity
DN409_RS19835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DN409_RS19840	COG0849	cell division
DN409_RS19845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DN409_RS19860	COG0772	Belongs to the SEDS family
DN409_RS19865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DN409_RS19870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN409_RS19875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DN409_RS19880	COG0768	penicillin binding
DN409_RS19885	COG0768	penicillin binding
DN409_RS19895	COG0275	rRNA processing
DN409_RS19900	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DN409_RS19905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN409_RS19910	COG0454	-acetyltransferase
DN409_RS19920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DN409_RS19925	COG1399	metal-binding, possibly nucleic acid-binding protein
DN409_RS19930	COG1323	Belongs to the UPF0348 family
DN409_RS19935	COG3480	Lon protease (S16) C-terminal proteolytic domain
DN409_RS19940	COG1752	Esterase of the alpha-beta hydrolase superfamily
DN409_RS19945	COG3314	Sporulation integral membrane protein YlbJ
DN409_RS19955	COG0742	ribosomal rna small subunit methyltransferase
DN409_RS19965	COG4471	UPF0298 protein
DN409_RS19970	COG3679	Belongs to the UPF0342 family
DN409_RS19975	COG0406	alpha-ribazole phosphatase activity
DN409_RS19990	COG2340	Cysteine-rich secretory protein family
DN409_RS20000	COG3336	cytochrome c oxidase
DN409_RS20025	COG0109	protoheme IX farnesyltransferase activity
DN409_RS20030	COG1612	heme a metabolic process
DN409_RS20035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DN409_RS20045	COG0772	Belongs to the SEDS family
DN409_RS20050	COG4838	Belongs to the UPF0358 family
DN409_RS20055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DN409_RS20060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DN409_RS20070	COG4896	Protein conserved in bacteria
DN409_RS20085	COG1217	gtp-binding protein TYPA
DN409_RS20095	COG0483	inositol monophosphate 1-phosphatase activity
DN409_RS20105	COG4493	Belongs to the UPF0637 family
DN409_RS20110	COG4476	Belongs to the UPF0223 family
DN409_RS20115	COG1982	Orn Lys Arg decarboxylase major
DN409_RS20160	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN409_RS20165	COG0022	dehydrogenase e1 component
DN409_RS20170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN409_RS20185	COG0561	phosphatase activity
DN409_RS20195	COG5503	Protein of unknown function (DUF1447)
DN409_RS20200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN409_RS20205	COG0569	domain protein
DN409_RS20215	COG1473	amidohydrolase
DN409_RS20220	COG2171	N-acyltransferase activity
DN409_RS20225	COG0583	DNA-binding transcription factor activity
DN409_RS20230	COG0517	IMP dehydrogenase activity
DN409_RS20240	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DN409_RS20250	COG4703	Protein of unknown function (DUF1797)
DN409_RS20265	COG2200	EAL domain
DN409_RS20270	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS20275	COG1408	metallophosphoesterase
DN409_RS20320	COG2814	Major facilitator Superfamily
DN409_RS20330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DN409_RS20340	COG3209	COG3209 Rhs family protein
DN409_RS20350	COG2205	protein histidine kinase activity
DN409_RS20360	COG0436	Aminotransferase
DN409_RS20365	COG1609	Transcriptional regulator
DN409_RS20370	COG3833	ABC-type maltose transport systems, permease component
DN409_RS20375	COG1175	transmembrane transport
DN409_RS20380	COG2182	Extracellular solute-binding protein
DN409_RS20390	COG0366	Alpha amylase catalytic
DN409_RS20395	COG3842	ATPase activity
DN409_RS20440	COG0183	Belongs to the thiolase family
DN409_RS20475	COG1695	Transcriptional regulator
DN409_RS20480	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS20490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DN409_RS20495	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DN409_RS20500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DN409_RS20505	COG0436	Aminotransferase
DN409_RS20510	COG1850	ribulose-bisphosphate carboxylase activity
DN409_RS20515	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DN409_RS20520	COG0235	Class ii aldolase
DN409_RS20525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DN409_RS20540	COG2084	Dehydrogenase
DN409_RS20550	COG2199	diguanylate cyclase activity
DN409_RS20555	COG0778	Nitroreductase
DN409_RS20580	COG1263	PTS System
DN409_RS20580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN409_RS20580	COG2190	(PTS) system
DN409_RS20585	COG3711	transcriptional antiterminator
DN409_RS20595	COG2188	Transcriptional regulator
DN409_RS20600	COG0363	glucosamine-6-phosphate deaminase activity
DN409_RS20605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DN409_RS20615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DN409_RS20625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DN409_RS20635	COG1547	Domain of unknown function (DUF309)
DN409_RS20645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN409_RS20650	COG4086	secreted protein
DN409_RS20655	COG0561	phosphatase activity
DN409_RS20660	COG0697	spore germination
DN409_RS20675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN409_RS20715	COG1686	Belongs to the peptidase S11 family
DN409_RS20720	COG1725	Transcriptional regulator
DN409_RS20725	COG1131	(ABC) transporter
DN409_RS20745	COG1846	Transcriptional regulator
DN409_RS20760	COG0598	Magnesium transport protein CorA
DN409_RS20775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DN409_RS20785	COG4974	Belongs to the 'phage' integrase family
DN409_RS20795	COG0735	belongs to the Fur family
DN409_RS20800	COG1300	Membrane
DN409_RS20820	COG0667	Aldo Keto reductase
DN409_RS20825	COG0656	L-ascorbic acid biosynthetic process
DN409_RS20830	COG0456	acetyltransferase
DN409_RS20830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN409_RS20840	COG1525	nuclease
DN409_RS20840	COG4085	toxin activity
DN409_RS20840	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS20850	COG0596	Alpha beta hydrolase
DN409_RS20855	COG2056	Na+-H+ antiporter family
DN409_RS20860	COG1609	Transcriptional regulator
DN409_RS20865	COG0456	acetyltransferase
DN409_RS20870	COG1073	alpha beta
DN409_RS20885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN409_RS20885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN409_RS20890	COG0307	riboflavin synthase, alpha
DN409_RS20895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN409_RS20895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN409_RS20915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DN409_RS20920	COG4106	trans-aconitate 2-methyltransferase activity
DN409_RS20925	COG2226	methyltransferase
DN409_RS20925	COG1073	alpha beta
DN409_RS20930	COG0156	8-amino-7-oxononanoate synthase activity
DN409_RS20940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN409_RS20950	COG1757	Na H antiporter
DN409_RS20955	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS20965	COG1522	sequence-specific DNA binding
DN409_RS20990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DN409_RS21000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DN409_RS21010	COG0300	oxidoreductase activity
DN409_RS21015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS21020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN409_RS21025	COG1760	l-serine dehydratase
DN409_RS21030	COG1760	l-serine dehydratase
DN409_RS21040	COG1234	tRNA 3'-trailer cleavage
DN409_RS21075	COG1131	(ABC) transporter
DN409_RS21105	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN409_RS21110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS21125	COG1376	ErfK ybiS ycfS ynhG family protein
DN409_RS21130	COG4129	membrane
DN409_RS21135	COG1126	abc transporter atp-binding protein
DN409_RS21140	COG0765	amino acid transport
DN409_RS21145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN409_RS21160	COG2816	NAD+ diphosphatase activity
DN409_RS21165	COG2323	membrane
DN409_RS21170	COG0772	Belongs to the SEDS family
DN409_RS21180	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN409_RS21185	COG0022	dehydrogenase e1 component
DN409_RS21190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN409_RS21195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN409_RS21200	COG3426	butyrate kinase activity
DN409_RS21210	COG0280	phosphate acetyltransferase
DN409_RS21220	COG3829	transcription factor binding
DN409_RS21220	COG3290	protein histidine kinase activity
DN409_RS21230	COG0584	glycerophosphoryl diester phosphodiesterase
DN409_RS21235	COG3093	addiction module antidote protein HigA
DN409_RS21275	COG0745	RESPONSE REGULATOR receiver
DN409_RS21285	COG0750	zinc metalloprotease
DN409_RS21290	COG0497	DNA recombination
DN409_RS21295	COG1438	arginine binding
DN409_RS21300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DN409_RS21305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN409_RS21310	COG0142	geranyltranstransferase activity
DN409_RS21315	COG1722	exodeoxyribonuclease VII activity
DN409_RS21320	COG1570	exodeoxyribonuclease VII activity
DN409_RS21325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN409_RS21330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN409_RS21335	COG1302	Protein conserved in bacteria
DN409_RS21340	COG0439	Biotin carboxylase
DN409_RS21345	COG0511	ligase activity, forming carbon-carbon bonds
DN409_RS21390	COG3854	ATPases associated with a variety of cellular activities
DN409_RS21410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DN409_RS21415	COG0006	proline dipeptidase activity
DN409_RS21420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DN409_RS21430	COG3872	metal-dependent enzyme
DN409_RS21440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN409_RS21445	COG1321	iron dependent repressor
DN409_RS21475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS21485	COG1609	Transcriptional regulator
DN409_RS21495	COG2076	Multidrug Resistance protein
DN409_RS21500	COG2076	Multidrug Resistance protein
DN409_RS21530	COG1131	(ABC) transporter
DN409_RS21535	COG1725	Transcriptional regulator
DN409_RS21550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DN409_RS21555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DN409_RS21560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DN409_RS21565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN409_RS21595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DN409_RS21620	COG4970	Tfp pilus assembly protein FimT
DN409_RS21630	COG1459	type II secretion system
DN409_RS21635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DN409_RS21690	COG0646	methionine synthase
DN409_RS21690	COG1410	methionine synthase
DN409_RS21695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DN409_RS21695	COG0646	methionine synthase
DN409_RS21700	COG0626	cystathionine gamma-synthase activity
DN409_RS21705	COG0626	cystathionine gamma-synthase activity
DN409_RS21720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS21730	COG1940	carbohydrate kinase activity
DN409_RS21735	COG4483	Protein conserved in bacteria
DN409_RS21740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DN409_RS21745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN409_RS21750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DN409_RS21755	COG0704	Plays a role in the regulation of phosphate uptake
DN409_RS21765	COG0581	inorganic phosphate transmembrane transporter activity
DN409_RS21770	COG0573	inorganic phosphate transmembrane transporter activity
DN409_RS21775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN409_RS21780	COG0768	penicillin binding
DN409_RS21785	COG0477	Major facilitator Superfamily
DN409_RS21790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN409_RS21810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DN409_RS21815	COG0735	belongs to the Fur family
DN409_RS21820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DN409_RS21825	COG1121	(ABC) transporter
DN409_RS21830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS21840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DN409_RS21855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DN409_RS21860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DN409_RS21865	COG2384	SAM-dependent methyltransferase
DN409_RS21875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN409_RS21880	COG0358	DNA primase activity
DN409_RS21890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DN409_RS21895	COG0517	IMP dehydrogenase activity
DN409_RS21900	COG1381	Involved in DNA repair and RecF pathway recombination
DN409_RS21910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DN409_RS21915	COG0295	cytidine deaminase activity
DN409_RS21920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DN409_RS21925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DN409_RS21930	COG1480	7TM receptor with intracellular HD hydrolase
DN409_RS21935	COG1702	phosphate starvation-inducible protein PhoH
DN409_RS21950	COG1610	YqeY-like protein
DN409_RS21955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DN409_RS21960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN409_RS21965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DN409_RS21975	COG0484	heat shock protein binding
DN409_RS21980	COG0443	Heat shock 70 kDa protein
DN409_RS21990	COG1420	regulation of RNA biosynthetic process
DN409_RS21995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN409_RS22000	COG1733	regulation of RNA biosynthetic process
DN409_RS22005	COG0481	GTPase activity
DN409_RS22015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DN409_RS22020	COG0268	Binds directly to 16S ribosomal RNA
DN409_RS22025	COG1466	dna polymerase III delta subunit
DN409_RS22040	COG2131	deaminase
DN409_RS22045	COG1555	photosystem II stabilization
DN409_RS22045	COG1596	polysaccharide export
DN409_RS22050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN409_RS22055	COG2226	methyltransferase
DN409_RS22060	COG0799	negative regulation of ribosome biogenesis
DN409_RS22065	COG1713	HD superfamily hydrolase involved in NAD metabolism
DN409_RS22070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DN409_RS22075	COG1534	Rna-binding protein
DN409_RS22080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DN409_RS22085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DN409_RS22090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DN409_RS22100	COG0688	phosphatidylethanolamine metabolic process
DN409_RS22115	COG2357	RelA SpoT domain protein
DN409_RS22125	COG1785	Belongs to the alkaline phosphatase family
DN409_RS22135	COG2267	carboxylic ester hydrolase activity
DN409_RS22170	COG1404	Belongs to the peptidase S8 family
DN409_RS22175	COG3186	Phenylalanine-4-hydroxylase
DN409_RS22180	COG2154	pterin-4-alpha-carbinolamine dehydratase
DN409_RS22185	COG2514	catechol 2,3-dioxygenase activity
DN409_RS22190	COG2259	Doxx family
DN409_RS22230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS22240	COG1454	alcohol dehydrogenase
DN409_RS22240	COG1012	belongs to the aldehyde dehydrogenase family
DN409_RS22245	COG0626	cystathionine gamma-synthase activity
DN409_RS22250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN409_RS22255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN409_RS22260	COG2226	methyltransferase
DN409_RS22275	COG0768	penicillin binding
DN409_RS22280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DN409_RS22285	COG0572	uridine kinase
DN409_RS22290	COG0826	peptidase U32
DN409_RS22295	COG0826	peptidase U32
DN409_RS22300	COG4122	O-methyltransferase activity
DN409_RS22305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN409_RS22315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DN409_RS22320	COG4472	Bacterial protein of unknown function (DUF965)
DN409_RS22325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN409_RS22335	COG0628	permease
DN409_RS22355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN409_RS22365	COG0482	sulfurtransferase activity
DN409_RS22370	COG1104	cysteine desulfurase activity
DN409_RS22375	COG1959	2 iron, 2 sulfur cluster binding
DN409_RS22380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DN409_RS22390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DN409_RS22395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DN409_RS22405	COG1490	D-aminoacyl-tRNA deacylase activity
DN409_RS22410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN409_RS22415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN409_RS22420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DN409_RS22420	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DN409_RS22425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DN409_RS22430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN409_RS22430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN409_RS22440	COG2244	polysaccharide biosynthetic process
DN409_RS22445	COG2323	membrane
DN409_RS22455	COG1862	Preprotein translocase
DN409_RS22460	COG0343	queuine tRNA-ribosyltransferase activity
DN409_RS22465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DN409_RS22475	COG2255	four-way junction helicase activity
DN409_RS22480	COG0632	four-way junction helicase activity
DN409_RS22485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DN409_RS22510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DN409_RS22515	COG0157	Belongs to the NadC ModD family
DN409_RS22520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DN409_RS22525	COG1104	cysteine desulfurase activity
DN409_RS22530	COG1827	regulation of RNA biosynthetic process
DN409_RS22535	COG2258	MOSC domain
DN409_RS22540	COG0077	Prephenate dehydratase
DN409_RS22545	COG0577	efflux transmembrane transporter activity
DN409_RS22550	COG0577	efflux transmembrane transporter activity
DN409_RS22555	COG1136	(ABC) transporter
DN409_RS22560	COG5002	protein histidine kinase activity
DN409_RS22565	COG0745	RESPONSE REGULATOR receiver
DN409_RS22570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DN409_RS22575	COG3290	protein histidine kinase activity
DN409_RS22585	COG2868	ribosomal protein
DN409_RS22595	COG1530	ribonuclease E activity
DN409_RS22605	COG1994	Peptidase M50
DN409_RS22610	COG0739	heme binding
DN409_RS22615	COG2894	cell division
DN409_RS22620	COG0850	regulation of cytokinetic process
DN409_RS22635	COG1077	Cell shape determining protein MreB Mrl
DN409_RS22640	COG2003	Belongs to the UPF0758 family
DN409_RS22645	COG0424	maF-like protein
DN409_RS22660	COG0285	dihydrofolate synthase activity
DN409_RS22675	COG1388	LysM domain
DN409_RS22680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DN409_RS22685	COG0113	porphobilinogen synthase activity
DN409_RS22690	COG1587	Uroporphyrinogen-III synthase
DN409_RS22695	COG0181	hydroxymethylbilane synthase activity
DN409_RS22700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DN409_RS22705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DN409_RS22710	COG1846	Transcriptional regulator
DN409_RS22715	COG1764	response to oxidative stress
DN409_RS22720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DN409_RS22730	COG1067	ATP-dependent peptidase activity
DN409_RS22730	COG0470	DNA polymerase III
DN409_RS22740	COG0544	peptidyl-prolyl cis-trans isomerase activity
DN409_RS22825	COG0582	viral genome integration into host DNA
DN409_RS22865	COG0622	Phosphoesterase
DN409_RS22875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DN409_RS22880	COG5401	PFAM Sporulation and spore germination
DN409_RS22890	COG2197	response regulator
DN409_RS22895	COG2233	PERMEase
DN409_RS22900	COG0402	S-adenosylhomocysteine deaminase activity
DN409_RS22905	COG1983	PspC domain protein
DN409_RS22910	COG1396	sequence-specific DNA binding
DN409_RS22915	COG0697	spore germination
DN409_RS22925	COG1959	2 iron, 2 sulfur cluster binding
DN409_RS22930	COG1668	transmembrane transport
DN409_RS22935	COG4152	abc transporter atp-binding protein
DN409_RS22940	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DN409_RS22945	COG1360	Flagellar Motor Protein
DN409_RS22950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DN409_RS22960	COG1876	peptidase activity
DN409_RS22965	COG0824	Thioesterase
DN409_RS22970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DN409_RS22975	COG1053	succinate dehydrogenase
DN409_RS22980	COG2009	succinate dehydrogenase
DN409_RS22985	COG1719	4-vinyl reductase, 4VR
DN409_RS22990	COG0322	excinuclease ABC activity
DN409_RS22995	COG3118	belongs to the thioredoxin family
DN409_RS23000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DN409_RS23005	COG2086	electron transfer activity
DN409_RS23010	COG1024	Enoyl-CoA hydratase
DN409_RS23015	COG1309	transcriptional regulator
DN409_RS23020	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS23035	COG2318	DinB family
DN409_RS23055	COG1131	(ABC) transporter
DN409_RS23060	COG2205	protein histidine kinase activity
DN409_RS23065	COG0745	RESPONSE REGULATOR receiver
DN409_RS23070	COG4895	conserved protein (DUF2196)
DN409_RS23075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DN409_RS23085	COG2329	Antibiotic biosynthesis monooxygenase
DN409_RS23090	COG4509	Sortase family
DN409_RS23095	COG1120	ATPase activity
DN409_RS23110	COG5386	Cell surface protein
DN409_RS23120	COG5386	Cell surface protein
DN409_RS23125	COG1114	Component of the transport system for branched-chain amino acids
DN409_RS23135	COG1193	negative regulation of DNA recombination
DN409_RS23140	COG1796	DNA polymerase
DN409_RS23140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN409_RS23145	COG1286	toxin biosynthetic process
DN409_RS23150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DN409_RS23155	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DN409_RS23185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DN409_RS23190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN409_RS23200	COG1418	mRNA catabolic process
DN409_RS23225	COG2814	Major facilitator Superfamily
DN409_RS23230	COG1566	PFAM secretion protein HlyD family protein
DN409_RS23235	COG1309	transcriptional regulator
DN409_RS23240	COG1363	Peptidase, m42
DN409_RS23250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DN409_RS23265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN409_RS23275	COG1484	DNA-dependent DNA replication
DN409_RS23280	COG3611	Membrane attachment protein
DN409_RS23285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN409_RS23290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DN409_RS23295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN409_RS23300	COG0237	dephospho-CoA kinase activity
DN409_RS23305	COG1971	Probably functions as a manganese efflux pump
DN409_RS23315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN409_RS23315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN409_RS23320	COG5002	protein histidine kinase activity
DN409_RS23325	COG0745	RESPONSE REGULATOR receiver
DN409_RS23340	COG0039	L-malate dehydrogenase activity
DN409_RS23345	COG0538	isocitrate dehydrogenase activity
DN409_RS23350	COG0372	Belongs to the citrate synthase family
DN409_RS23365	COG0628	permease
DN409_RS23370	COG3030	protein affecting phage T7 exclusion by the F plasmid
DN409_RS23380	COG0205	6-phosphofructokinase activity
DN409_RS23390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DN409_RS23395	COG1725	Transcriptional regulator
DN409_RS23400	COG0281	malic enzyme
DN409_RS23405	COG0587	DNA-directed DNA polymerase activity
DN409_RS23420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DN409_RS23440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS23450	COG4109	DRTGG domain
DN409_RS23455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DN409_RS23460	COG0006	proline dipeptidase activity
DN409_RS23485	COG0662	Cupin 2, conserved barrel domain protein
DN409_RS23495	COG1476	TRANSCRIPTIONal
DN409_RS23510	COG1028	Short-chain dehydrogenase reductase Sdr
DN409_RS23515	COG0589	response to stress
DN409_RS23535	COG0165	Argininosuccinate lyase
DN409_RS23540	COG0137	argininosuccinate synthase activity
DN409_RS23555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS23575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DN409_RS23580	COG0827	DNA restriction-modification system
DN409_RS23585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DN409_RS23590	COG3874	Sporulation protein YtfJ
DN409_RS23605	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DN409_RS23615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN409_RS23630	COG1104	cysteine desulfurase activity
DN409_RS23640	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DN409_RS23650	COG1309	transcriptional regulator
DN409_RS23655	COG1956	GAF domain-containing protein
DN409_RS23660	COG0626	cystathionine gamma-synthase activity
DN409_RS23665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DN409_RS23690	COG1595	DNA-templated transcription, initiation
DN409_RS23700	COG0110	maltose O-acetyltransferase activity
DN409_RS23705	COG0456	acetyltransferase
DN409_RS23710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN409_RS23715	COG0454	-acetyltransferase
DN409_RS23720	COG0517	IMP dehydrogenase activity
DN409_RS23725	COG0123	including yeast histone deacetylase and acetoin utilization protein
DN409_RS23730	COG2267	carboxylic ester hydrolase activity
DN409_RS23740	COG0745	RESPONSE REGULATOR receiver
DN409_RS23745	COG5002	protein histidine kinase activity
DN409_RS23750	COG0666	response to abiotic stimulus
DN409_RS23760	COG1970	mechanosensitive ion channel activity
DN409_RS23780	COG1609	Transcriptional regulator
DN409_RS23785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN409_RS23785	COG1605	Chorismate mutase
DN409_RS23790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN409_RS23790	COG1605	Chorismate mutase
DN409_RS23795	COG4851	CamS sex pheromone cAM373 precursor
DN409_RS23800	COG3118	belongs to the thioredoxin family
DN409_RS23810	COG2309	aminopeptidase activity
DN409_RS23830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS23835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DN409_RS23845	COG1674	ftsk spoiiie
DN409_RS23860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN409_RS23865	COG4848	Belongs to the UPF0354 family
DN409_RS23870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS23875	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DN409_RS23880	COG1363	Peptidase, m42
DN409_RS23890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS23895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DN409_RS23905	COG0510	thiamine kinase activity
DN409_RS23910	COG1523	belongs to the glycosyl hydrolase 13 family
DN409_RS23920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN409_RS23925	COG1349	DNA-binding transcription factor activity
DN409_RS23930	COG1187	pseudouridine synthase activity
DN409_RS23935	COG2244	polysaccharide biosynthetic process
DN409_RS23940	COG2081	HI0933 family
DN409_RS23945	COG2814	Major facilitator Superfamily
DN409_RS23955	COG3832	glyoxalase III activity
DN409_RS23975	COG1329	Transcriptional regulator
DN409_RS24000	COG0314	molybdopterin synthase activity
DN409_RS24005	COG1763	Mo-molybdopterin cofactor biosynthetic process
DN409_RS24010	COG0303	'Molybdopterin
DN409_RS24015	COG0315	cyclic pyranopterin monophosphate synthase activity
DN409_RS24020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN409_RS24025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN409_RS24050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN409_RS24060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DN409_RS24100	COG0495	leucyl-tRNA aminoacylation
DN409_RS24105	COG2814	Major facilitator Superfamily
DN409_RS24110	COG0475	glutathione-regulated potassium exporter activity
DN409_RS24115	COG0490	domain, Protein
DN409_RS24120	COG0582	viral genome integration into host DNA
DN409_RS24135	COG1136	(ABC) transporter
DN409_RS24150	COG1242	4 iron, 4 sulfur cluster binding
DN409_RS24155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DN409_RS24175	COG2267	carboxylic ester hydrolase activity
DN409_RS24180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DN409_RS24185	COG0671	phosphoesterase, PA-phosphatase related
DN409_RS24190	COG0438	transferase activity, transferring glycosyl groups
DN409_RS24205	COG0746	molybdenum cofactor guanylyltransferase activity
DN409_RS24225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DN409_RS24230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DN409_RS24275	COG5002	protein histidine kinase activity
DN409_RS24280	COG3852	Histidine kinase
DN409_RS24285	COG0753	catalase activity
DN409_RS24290	COG2267	carboxylic ester hydrolase activity
DN409_RS24300	COG1368	sulfuric ester hydrolase activity
DN409_RS24310	COG4895	conserved protein (DUF2196)
DN409_RS24325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN409_RS24330	COG1116	anion transmembrane transporter activity
DN409_RS24335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN409_RS24355	COG0494	nUDIX hydrolase
DN409_RS24400	COG2076	Multidrug Resistance protein
DN409_RS24405	COG2076	Multidrug Resistance protein
DN409_RS24410	COG0789	Transcriptional regulator
DN409_RS24415	COG1854	S-ribosylhomocysteine lyase activity
DN409_RS24425	COG0288	reversible hydration of carbon dioxide
DN409_RS24430	COG1271	oxidase subunit
DN409_RS24435	COG1294	oxidase, subunit
DN409_RS24455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS24475	COG1842	Phage shock protein A
DN409_RS24500	COG3859	Proton-coupled thiamine transporter YuaJ
DN409_RS24505	COG5002	protein histidine kinase activity
DN409_RS24510	COG0745	RESPONSE REGULATOR receiver
DN409_RS24535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN409_RS24540	COG1597	lipid kinase activity
DN409_RS24580	COG0586	Pfam SNARE associated Golgi protein
DN409_RS24595	COG0577	efflux transmembrane transporter activity
DN409_RS24600	COG1136	(ABC) transporter
DN409_RS24605	COG3708	Transcriptional regulator
DN409_RS24605	COG2207	Transcriptional regulator
DN409_RS24615	COG1131	(ABC) transporter
DN409_RS24620	COG5658	integral membrane protein
DN409_RS24625	COG0640	Transcriptional regulator
DN409_RS24630	COG0745	RESPONSE REGULATOR receiver
DN409_RS24635	COG2205	protein histidine kinase activity
DN409_RS24640	COG0577	efflux transmembrane transporter activity
DN409_RS24645	COG0577	efflux transmembrane transporter activity
DN409_RS24650	COG1136	(ABC) transporter
DN409_RS24655	COG0577	efflux transmembrane transporter activity
DN409_RS24670	COG2188	Transcriptional regulator
DN409_RS24690	COG3964	amidohydrolase
DN409_RS24710	COG4948	Mandelate Racemase Muconate Lactonizing
DN409_RS24715	COG0318	PFAM AMP-dependent synthetase and ligase
DN409_RS24720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DN409_RS24730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DN409_RS24735	COG1169	isochorismate synthase
DN409_RS24740	COG1575	Belongs to the MenA family. Type 1 subfamily
DN409_RS24745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DN409_RS24750	COG1278	Cold shock
DN409_RS24760	COG0789	Transcriptional regulator
DN409_RS24770	COG0058	SHG alpha-glucan phosphorylase activity
DN409_RS24780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN409_RS24785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN409_RS24790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DN409_RS24940	COG1285	pathogenesis
DN409_RS24945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN409_RS24955	COG0166	Belongs to the GPI family
DN409_RS24965	COG2155	Conserved Protein
DN409_RS24970	COG1098	S1 RNA binding domain
DN409_RS24975	COG0436	Aminotransferase
DN409_RS24980	COG1522	sequence-specific DNA binding
DN409_RS24985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN409_RS24990	COG2267	carboxylic ester hydrolase activity
DN409_RS25000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DN409_RS25015	COG5018	Exonuclease
DN409_RS25020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN409_RS25040	COG2050	protein possibly involved in aromatic compounds catabolism
DN409_RS25050	COG1268	BioY protein
DN409_RS25055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN409_RS25060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN409_RS25070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DN409_RS25075	COG3584	3D domain protein
DN409_RS25090	COG1252	NADH dehydrogenase
DN409_RS25095	COG0492	ferredoxin-NADP+ reductase activity
DN409_RS25100	COG3708	Transcriptional regulator
DN409_RS25115	COG1683	Conserved Protein
DN409_RS25140	COG0316	Belongs to the HesB IscA family
DN409_RS25145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DN409_RS25150	COG4844	belongs to the
DN409_RS25155	COG1252	NADH dehydrogenase
DN409_RS25165	COG0390	transport system, permease component
DN409_RS25170	COG2824	Alkylphosphonate utilization operon protein PhnA
DN409_RS25195	COG4837	Protein of unknown function (DUF1462)
DN409_RS25200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DN409_RS25210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN409_RS25215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DN409_RS25235	COG0577	efflux transmembrane transporter activity
DN409_RS25235	COG1136	(ABC) transporter
DN409_RS25240	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN409_RS25250	COG0647	UMP catabolic process
DN409_RS25260	COG2445	Protein of unknown function DUF86
DN409_RS25265	COG1494	fructose-1,6-bisphosphatase
DN409_RS25285	COG4470	Protein conserved in bacteria
DN409_RS25295	COG0789	Transcriptional regulator
DN409_RS25300	COG4377	Putative membrane peptidase family (DUF2324)
DN409_RS25320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DN409_RS25325	COG0739	heme binding
DN409_RS25335	COG3377	Domain of unknown function (DUF1805)
DN409_RS25340	COG0737	Belongs to the 5'-nucleotidase family
DN409_RS25345	COG0719	Fe-S assembly protein
DN409_RS25350	COG0822	iron-sulfur transferase activity
DN409_RS25355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN409_RS25360	COG0719	Fe-S assembly protein
DN409_RS25365	COG0396	ATPase activity
DN409_RS25370	COG1464	Belongs to the NlpA lipoprotein family
DN409_RS25375	COG1464	Belongs to the NlpA lipoprotein family
DN409_RS25380	COG2011	ABC-type metal ion transport system permease component
DN409_RS25395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN409_RS25400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DN409_RS25405	COG0509	glycine decarboxylation via glycine cleavage system
DN409_RS25410	COG1393	Belongs to the ArsC family
DN409_RS25445	COG1309	transcriptional regulator
DN409_RS25450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS25455	COG1960	acyl-CoA dehydrogenase activity
DN409_RS25460	COG0183	Belongs to the thiolase family
DN409_RS25465	COG1024	Enoyl-CoA hydratase
DN409_RS25465	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN409_RS25475	COG1686	Belongs to the peptidase S11 family
DN409_RS25480	COG0506	proline dehydrogenase activity
DN409_RS25490	COG0011	TIGRFAM Protein of
DN409_RS25495	COG0840	transmembrane signaling receptor activity
DN409_RS25510	COG2814	Major facilitator Superfamily
DN409_RS25515	COG0531	amino acid
DN409_RS25540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN409_RS25570	COG0586	Pfam SNARE associated Golgi protein
DN409_RS25580	COG1376	ErfK ybiS ycfS ynhG family protein
DN409_RS25585	COG0745	RESPONSE REGULATOR receiver
DN409_RS25590	COG5002	protein histidine kinase activity
DN409_RS25600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN409_RS25610	COG0840	transmembrane signaling receptor activity
DN409_RS25620	COG2151	metal-sulfur cluster biosynthetic enzyme
DN409_RS25625	COG3227	Zinc metalloprotease (Elastase)
DN409_RS25630	COG1741	Belongs to the pirin family
DN409_RS25645	COG0586	Pfam SNARE associated Golgi protein
DN409_RS25650	COG0475	glutathione-regulated potassium exporter activity
DN409_RS25655	COG0490	domain, Protein
DN409_RS25660	COG1115	amino acid carrier protein
DN409_RS25665	COG0783	Belongs to the Dps family
DN409_RS25675	COG2318	DinB family
DN409_RS25680	COG1611	Belongs to the LOG family
DN409_RS25690	COG1528	Iron-storage protein
DN409_RS25695	COG2311	Membrane
DN409_RS25700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS25705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS25710	COG1115	amino acid carrier protein
DN409_RS25715	COG2910	NAD(P)H-binding
DN409_RS25745	COG0656	L-ascorbic acid biosynthetic process
DN409_RS25750	COG2814	Major facilitator Superfamily
DN409_RS25755	COG1733	regulation of RNA biosynthetic process
DN409_RS25765	COG1252	NADH dehydrogenase
DN409_RS25785	COG0840	transmembrane signaling receptor activity
DN409_RS25785	COG3290	protein histidine kinase activity
DN409_RS25810	COG3655	Transcriptional regulator
DN409_RS25825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN409_RS25835	COG1733	regulation of RNA biosynthetic process
DN409_RS25840	COG0778	Nitroreductase
DN409_RS25845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN409_RS25850	COG4224	UPF0291 protein
DN409_RS25855	COG1522	sequence-specific DNA binding
DN409_RS25860	COG0288	reversible hydration of carbon dioxide
DN409_RS25865	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DN409_RS25870	COG2233	PERMEase
DN409_RS25915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DN409_RS25925	COG0557	exoribonuclease II activity
DN409_RS25930	COG1647	Serine aminopeptidase, S33
DN409_RS25935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN409_RS25940	COG1346	cytolysis
DN409_RS25955	COG0148	phosphopyruvate hydratase activity
DN409_RS25965	COG0149	triose-phosphate isomerase activity
DN409_RS25970	COG0126	phosphoglycerate kinase activity
DN409_RS25975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN409_RS25990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DN409_RS26015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN409_RS26030	COG2323	membrane
DN409_RS26045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN409_RS26050	COG1481	regulation of sporulation
DN409_RS26055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DN409_RS26060	COG1660	Displays ATPase and GTPase activities
DN409_RS26065	COG1051	belongs to the nudix hydrolase family
DN409_RS26075	COG0492	ferredoxin-NADP+ reductase activity
DN409_RS26080	COG0457	Tetratricopeptide repeat
DN409_RS26085	COG0110	maltose O-acetyltransferase activity
DN409_RS26090	COG0546	phosphoglycolate phosphatase activity
DN409_RS26095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DN409_RS26100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DN409_RS26105	COG1950	PFAM Membrane protein of
DN409_RS26115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN409_RS26135	COG0789	Transcriptional regulator
DN409_RS26170	COG0583	DNA-binding transcription factor activity
DN409_RS26180	COG0655	NAD(P)H dehydrogenase (quinone) activity
DN409_RS26185	COG0488	(ABC) transporter
DN409_RS26195	COG1132	(ABC) transporter
DN409_RS26200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN409_RS26205	COG0793	Belongs to the peptidase S41A family
DN409_RS26205	COG3409	Peptidoglycan-binding domain 1 protein
DN409_RS26210	COG2177	Part of the ABC transporter FtsEX involved in
DN409_RS26215	COG2884	Cell division ATP-binding protein ftsE
DN409_RS26255	COG1278	Cold shock
DN409_RS26260	COG1040	competence protein
DN409_RS26265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DN409_RS26270	COG0791	NLP P60 protein
DN409_RS26270	COG1388	LysM domain
DN409_RS26275	COG1733	regulation of RNA biosynthetic process
DN409_RS26280	COG1307	EDD domain protein, DegV family
DN409_RS26285	COG1739	Uncharacterized protein family UPF0029
DN409_RS26290	COG1316	TRANSCRIPTIONal
DN409_RS26295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DN409_RS26300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DN409_RS26305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN409_RS26315	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DN409_RS26315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DN409_RS26335	COG1486	melibiose metabolic process
DN409_RS26340	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN409_RS26345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN409_RS26355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DN409_RS26365	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN409_RS26375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN409_RS26380	COG1301	dicarboxylic acid transport
DN409_RS26395	COG1511	domain protein
DN409_RS26400	COG0583	DNA-binding transcription factor activity
DN409_RS26405	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DN409_RS26410	COG1271	oxidase subunit
DN409_RS26415	COG1294	oxidase, subunit
DN409_RS26420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN409_RS26425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DN409_RS26430	COG1620	l-lactate permease
DN409_RS26440	COG2389	metal-binding protein
DN409_RS26455	COG1368	sulfuric ester hydrolase activity
DN409_RS26465	COG1388	LysM domain
DN409_RS26465	COG0791	NLP P60 protein
DN409_RS26470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN409_RS26480	COG1215	transferase activity, transferring glycosyl groups
DN409_RS26485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DN409_RS26495	COG3584	3D domain protein
DN409_RS26495	COG1388	LysM domain
DN409_RS26520	COG4715	Zinc finger, swim domain protein
DN409_RS26525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN409_RS26565	COG0577	efflux transmembrane transporter activity
DN409_RS26570	COG1136	(ABC) transporter
DN409_RS26605	COG5002	protein histidine kinase activity
DN409_RS26605	COG3850	Histidine kinase
DN409_RS26610	COG0745	RESPONSE REGULATOR receiver
DN409_RS26620	COG1316	TRANSCRIPTIONal
DN409_RS26640	COG0438	transferase activity, transferring glycosyl groups
DN409_RS26655	COG0438	transferase activity, transferring glycosyl groups
DN409_RS26670	COG1086	Polysaccharide biosynthesis protein
DN409_RS26680	COG1045	serine acetyltransferase
DN409_RS26685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DN409_RS26690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DN409_RS26695	COG1086	Polysaccharide biosynthesis protein
DN409_RS26700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN409_RS26705	COG4464	protein tyrosine phosphatase activity
DN409_RS26710	COG0489	protein tyrosine kinase activity
DN409_RS26715	COG3944	biosynthesis protein
DN409_RS26720	COG0489	protein tyrosine kinase activity
DN409_RS26740	COG1609	Transcriptional regulator
DN409_RS26750	COG0739	heme binding
DN409_RS26765	COG3279	Response regulator of the LytR AlgR family
DN409_RS26770	COG2385	sporulation resulting in formation of a cellular spore
DN409_RS26785	COG4836	Membrane
DN409_RS26790	COG1007	ATP synthesis coupled electron transport
DN409_RS26795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN409_RS26800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DN409_RS26805	COG0713	ATP synthesis coupled electron transport
DN409_RS26810	COG0839	Belongs to the complex I subunit 6 family
DN409_RS26820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DN409_RS26825	COG0649	NAD binding
DN409_RS26830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN409_RS26835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN409_RS26840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN409_RS26845	COG5001	Diguanylate cyclase
DN409_RS26845	COG3300	MHYT domain
DN409_RS26860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DN409_RS26865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DN409_RS26870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DN409_RS26875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DN409_RS26880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN409_RS26885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DN409_RS26895	COG0356	it plays a direct role in the translocation of protons across the membrane
DN409_RS26920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DN409_RS26930	COG0698	ribose 5-phosphate isomerase
DN409_RS26940	COG2190	(PTS) system
DN409_RS26945	COG2259	Doxx family
DN409_RS26950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DN409_RS26960	COG1971	Probably functions as a manganese efflux pump
DN409_RS26965	COG0009	L-threonylcarbamoyladenylate synthase
DN409_RS26980	COG2890	protein-(glutamine-N5) methyltransferase activity
DN409_RS26985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DN409_RS26990	COG1435	thymidine kinase activity
DN409_RS27005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DN409_RS27010	COG1494	fructose-1,6-bisphosphatase
DN409_RS27030	COG4821	SIS domain
DN409_RS27035	COG0504	CTP synthase activity
DN409_RS27040	COG3343	RNA polymerase activity
DN409_RS27050	COG1960	acyl-CoA dehydrogenase activity
DN409_RS27055	COG1960	acyl-CoA dehydrogenase activity
DN409_RS27060	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN409_RS27065	COG0183	Belongs to the thiolase family
DN409_RS27070	COG0247	lactate metabolic process
DN409_RS27070	COG2181	nitrate reductase activity
DN409_RS27075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN409_RS27080	COG4294	response to UV
DN409_RS27085	COG5001	Diguanylate cyclase
DN409_RS27085	COG3300	MHYT domain
DN409_RS27100	COG3227	Zinc metalloprotease (Elastase)
DN409_RS27105	COG2197	response regulator
DN409_RS27110	COG4585	Histidine kinase
DN409_RS27115	COG0842	Transport permease protein
DN409_RS27120	COG1131	(ABC) transporter
DN409_RS27125	COG0024	Methionine aminopeptidase
DN409_RS27135	COG2234	aminopeptidase activity
DN409_RS27155	COG4506	Protein conserved in bacteria
DN409_RS27160	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN409_RS27180	COG0010	Belongs to the arginase family
DN409_RS27185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DN409_RS27190	COG2814	Major facilitator Superfamily
DN409_RS27195	COG0789	Transcriptional regulator
DN409_RS27200	COG0584	glycerophosphoryl diester phosphodiesterase
DN409_RS27205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN409_RS27215	COG1994	Peptidase M50
DN409_RS27225	COG1078	dGTPase activity
DN409_RS27230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN409_RS27235	COG1120	ATPase activity
DN409_RS27240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS27245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN409_RS27250	COG4844	belongs to the
DN409_RS27265	COG0280	phosphate acetyltransferase
DN409_RS27270	COG3253	May function as heme-dependent peroxidase
DN409_RS27280	COG3773	Cell wall hydrolase
DN409_RS27290	COG2363	Small membrane protein
DN409_RS27305	COG2233	PERMEase
DN409_RS27310	COG0561	phosphatase activity
DN409_RS27315	COG2814	Major facilitator Superfamily
DN409_RS27320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DN409_RS27325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DN409_RS27330	COG1131	(ABC) transporter
DN409_RS27335	COG2755	lipolytic protein G-D-S-L family
DN409_RS27340	COG1609	Transcriptional regulator
DN409_RS27350	COG0460	homoserine dehydrogenase
DN409_RS27355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DN409_RS27360	COG2873	o-acetylhomoserine
DN409_RS27370	COG1011	Hydrolase
DN409_RS27375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN409_RS27385	COG2197	response regulator
DN409_RS27390	COG4585	Histidine kinase
DN409_RS27390	COG2203	Gaf domain
DN409_RS27395	COG0351	phosphomethylpyrimidine kinase
DN409_RS27400	COG3706	GGDEF domain
DN409_RS27405	COG2879	small protein
DN409_RS27410	COG1966	Carbon starvation protein
DN409_RS27415	COG3279	Response regulator of the LytR AlgR family
DN409_RS27420	COG0477	Major facilitator Superfamily
DN409_RS27445	COG0840	transmembrane signaling receptor activity
DN409_RS27455	COG1607	acyl-coa hydrolase
DN409_RS27460	COG1216	Glycosyl transferase, family 2
DN409_RS27470	COG1216	Glycosyl transferase, family 2
DN409_RS27480	COG0488	(ABC) transporter
DN409_RS27485	COG1309	transcriptional regulator
DN409_RS27490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN409_RS27495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN409_RS27495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN409_RS27500	COG0628	permease
DN409_RS27510	COG1380	Effector of murein hydrolase LrgA
DN409_RS27515	COG3279	Response regulator of the LytR AlgR family
DN409_RS27520	COG3275	phosphorelay sensor kinase activity
DN409_RS27525	COG2814	Major facilitator Superfamily
DN409_RS27530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DN409_RS27535	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DN409_RS27545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN409_RS27595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DN409_RS27600	COG1272	protein, Hemolysin III
DN409_RS27625	COG1164	Oligoendopeptidase f
DN409_RS27635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DN409_RS27645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN409_RS27650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DN409_RS27655	COG4853	Protein conserved in bacteria
DN409_RS27665	COG5002	protein histidine kinase activity
DN409_RS27670	COG0745	RESPONSE REGULATOR receiver
DN409_RS27700	COG0305	Participates in initiation and elongation during chromosome replication
DN409_RS27705	COG0359	binds to the 23S rRNA
DN409_RS27710	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DN409_RS27715	COG4241	membrane
DN409_RS27725	COG0629	single-stranded DNA binding
DN409_RS27730	COG0360	Binds together with S18 to 16S ribosomal RNA
DN409_RS27735	COG0012	GTP binding
DN409_RS27740	COG4481	Protein conserved in bacteria
DN409_RS27745	COG0668	transmembrane transport
DN409_RS27755	COG1475	DNA binding
DN409_RS27760	COG1192	Involved in chromosome partitioning
DN409_RS27765	COG1475	DNA binding
DN409_RS27770	COG0357	Ribosomal RNA small subunit methyltransferase G
DN409_RS27775	COG0445	tRNA wobble uridine modification
DN409_RS27780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DN409_RS27785	COG1847	R3H domain protein
DN409_RS27790	COG0706	membrane insertase activity
DN409_RS27795	COG0594	ribonuclease P activity
DN409_RS27800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DN409_RS27820	COG5002	protein histidine kinase activity
DN409_RS27900	COG0778	Nitroreductase
DN409_RS27940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN409_RS27955	COG1674	ftsk spoiiie
DN409_RS27970	COG0741	lytic transglycosylase activity
DN409_RS28070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN409_RS28095	COG0367	asparagine synthase
DN409_RS28145	COG0739	heme binding
DN409_RS28200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DN409_RS28220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DN409_RS28220	COG2755	lipolytic protein G-D-S-L family
DN409_RS28240	COG0756	dUTP diphosphatase activity
DN409_RS28290	COG0463	Glycosyl transferase, family 2
DN409_RS28295	COG0463	Glycosyl transferase, family 2
DN409_RS28300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DN409_RS28305	COG1086	Polysaccharide biosynthesis protein
DN409_RS28310	COG1088	dTDP-glucose 4,6-dehydratase activity
DN409_RS28315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DN409_RS28320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DN409_RS28335	COG2089	acid synthase
DN409_RS28340	COG4641	Protein conserved in bacteria
DN409_RS28410	COG0745	RESPONSE REGULATOR receiver
DN409_RS28415	COG2205	protein histidine kinase activity
DN409_RS28430	COG1136	(ABC) transporter
DN409_RS28435	COG0577	efflux transmembrane transporter activity
DN409_RS28445	COG2002	toxin-antitoxin pair type II binding
DN409_RS28455	COG1923	regulation of RNA biosynthetic process
DN409_RS28485	COG2814	Major facilitator Superfamily
DN409_RS28510	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DN409_RS28525	COG2002	toxin-antitoxin pair type II binding
DN409_RS28560	COG0582	viral genome integration into host DNA
DN409_RS28595	COG1696	Membrane protein involved in D-alanine export
DN409_RS28605	COG2814	Major facilitator Superfamily
DN409_RS28650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DN409_RS28675	COG1388	LysM domain
DN409_RS28675	COG3103	Sh3 type 3 domain protein
DN409_RS28675	COG0791	NLP P60 protein
DN409_RS28690	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DN409_RS28705	COG0583	DNA-binding transcription factor activity
DN409_RS28710	COG0768	penicillin binding
DN409_RS28720	COG4990	cell redox homeostasis
DN409_RS28725	COG0745	RESPONSE REGULATOR receiver
DN409_RS28730	COG5002	protein histidine kinase activity
DN409_RS28745	COG0745	RESPONSE REGULATOR receiver
DN409_RS28775	COG0833	amino acid
DN409_RS28780	COG1285	pathogenesis
DN409_RS28790	COG2267	carboxylic ester hydrolase activity
DN409_RS28805	COG0840	transmembrane signaling receptor activity
DN409_RS28845	COG0083	homoserine kinase activity
DN409_RS28875	COG4974	Belongs to the 'phage' integrase family
DN409_RS28890	COG1923	regulation of RNA biosynthetic process
DN409_RS28905	COG2002	toxin-antitoxin pair type II binding
DN409_RS28910	COG0658	competence protein
DN409_RS28910	COG2333	competence protein COMEC
DN409_RS28965	COG2423	ornithine cyclodeaminase activity
DN409_RS28975	COG2175	clavaminate synthase activity
DN409_RS28980	COG0137	argininosuccinate synthase activity
DN409_RS28995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN409_RS29000	COG0251	oxidation-reduction process
DN409_RS29010	COG0736	holo-[acyl-carrier-protein] synthase activity
DN409_RS29015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN409_RS29020	COG1960	acyl-CoA dehydrogenase activity
DN409_RS29045	COG0556	nucleotide-excision repair
DN409_RS29050	COG0039	L-malate dehydrogenase activity
DN409_RS29070	COG0436	Aminotransferase
DN409_RS29110	COG0492	ferredoxin-NADP+ reductase activity
DN409_RS29125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DN409_RS29125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DN409_RS29135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN409_RS29140	COG1960	acyl-CoA dehydrogenase activity
DN409_RS29155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DN409_RS29165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DN409_RS29195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DN409_RS29205	COG0438	transferase activity, transferring glycosyl groups
DN409_RS29210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN409_RS29215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DN409_RS29230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN409_RS29240	COG1131	(ABC) transporter
DN409_RS29255	COG2378	regulation of single-species biofilm formation
DN409_RS29295	COG2002	toxin-antitoxin pair type II binding
DN409_RS29365	COG2814	Major facilitator Superfamily
DN409_RS29370	COG0583	DNA-binding transcription factor activity
DN409_RS29455	COG2357	RelA SpoT domain protein
DN409_RS29460	COG2814	Major facilitator Superfamily
DN409_RS29470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN409_RS29480	COG2031	fatty acid transporter
DN409_RS29585	COG3883	PFAM NLP P60 protein
DN409_RS29585	COG0791	NLP P60 protein
DN409_RS29670	COG1396	sequence-specific DNA binding
DN409_RS29700	COG0024	Methionine aminopeptidase
DN409_RS29835	COG5484	DNA packaging
DN409_RS30030	COG0419	ATPase involved in DNA repair
DN409_RS30090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DN409_RS30235	COG1674	ftsk spoiiie
DN409_RS30365	COG3011	Protein conserved in bacteria
DN409_RS30405	COG4974	Belongs to the 'phage' integrase family
DN409_RS30495	COG1192	Involved in chromosome partitioning
DN409_RS30515	COG0484	heat shock protein binding
DN409_RS30535	COG0741	lytic transglycosylase activity
DN409_RS30535	COG0791	NLP P60 protein
DN409_RS30605	COG1674	ftsk spoiiie
DN409_RS30625	COG1780	Probably involved in ribonucleotide reductase function
DN409_RS30660	COG3209	COG3209 Rhs family protein
DN409_RS30685	COG0582	viral genome integration into host DNA
DN409_RS30745	COG0582	viral genome integration into host DNA