locus-tag	class	description
EXW52_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW52_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW52_RS00015	COG2501	S4 domain
EXW52_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW52_RS00025	COG0187	DNA topoisomerase II activity
EXW52_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW52_RS00065	COG0516	GMP reductase activity
EXW52_RS00065	COG0517	IMP dehydrogenase activity
EXW52_RS00070	COG1686	Belongs to the peptidase S11 family
EXW52_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW52_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW52_RS00100	COG1428	Deoxynucleoside kinase
EXW52_RS00105	COG1428	Deoxynucleoside kinase
EXW52_RS00110	COG1335	isochorismatase
EXW52_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW52_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW52_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW52_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW52_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW52_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW52_RS00190	COG0470	DNA polymerase III
EXW52_RS00195	COG1774	PSP1 C-terminal conserved region
EXW52_RS00200	COG4467	Involved in initiation control of chromosome replication
EXW52_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW52_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW52_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW52_RS00230	COG0084	hydrolase, TatD family'
EXW52_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW52_RS00250	COG4466	Protein conserved in bacteria
EXW52_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW52_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW52_RS00270	COG0251	oxidation-reduction process
EXW52_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW52_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW52_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW52_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW52_RS00310	COG2244	polysaccharide biosynthetic process
EXW52_RS00315	COG3956	TIGRFAM MazG family protein
EXW52_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW52_RS00340	COG1098	S1 RNA binding domain
EXW52_RS00355	COG2208	phosphoserine phosphatase activity
EXW52_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW52_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW52_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW52_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW52_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW52_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW52_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW52_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW52_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW52_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW52_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW52_RS00420	COG1396	sequence-specific DNA binding
EXW52_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW52_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW52_RS00515	COG3880	PFAM UvrB UvrC protein
EXW52_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW52_RS00525	COG0542	response to heat
EXW52_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW52_RS00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW52_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW52_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW52_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW52_RS00560	COG1045	serine acetyltransferase
EXW52_RS00565	COG0215	cysteine-tRNA ligase activity
EXW52_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW52_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW52_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW52_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW52_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW52_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW52_RS00610	COG0081	regulation of translation
EXW52_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW52_RS00620	COG0222	ribosome binding
EXW52_RS00625	COG2813	Specifically methylates the guanine in position
EXW52_RS00630	COG0085	RNA polymerase activity
EXW52_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW52_RS00640	COG1358	cellular component organization or biogenesis
EXW52_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW52_RS00650	COG0049	tRNA binding
EXW52_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW52_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW52_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW52_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW52_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EXW52_RS00680	COG0089	rRNA binding
EXW52_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW52_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW52_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW52_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW52_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW52_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW52_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW52_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW52_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW52_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW52_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW52_RS00760	COG1841	ribosomal large subunit assembly
EXW52_RS00765	COG0200	Binds to the 23S rRNA
EXW52_RS00770	COG0201	protein transport
EXW52_RS00775	COG0563	adenylate kinase activity
EXW52_RS00780	COG0024	Methionine aminopeptidase
EXW52_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW52_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW52_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW52_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW52_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW52_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW52_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS00855	COG0489	protein tyrosine kinase activity
EXW52_RS00865	COG2194	sulfuric ester hydrolase activity
EXW52_RS00870	COG0726	polysaccharide deacetylase
EXW52_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW52_RS00955	COG4856	YbbR-like protein
EXW52_RS00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW52_RS00970	COG0823	Involved in the tonB-independent uptake of proteins
EXW52_RS00970	COG1506	peptidase
EXW52_RS00970	COG4946	Tricorn protease homolog
EXW52_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS00990	COG2011	ABC-type metal ion transport system permease component
EXW52_RS01000	COG1464	Belongs to the NlpA lipoprotein family
EXW52_RS01005	COG0604	alcohol dehydrogenase
EXW52_RS01015	COG0277	FAD linked oxidase domain protein
EXW52_RS01020	COG2271	Major facilitator Superfamily
EXW52_RS01030	COG2814	Major facilitator Superfamily
EXW52_RS01045	COG0601	transmembrane transport
EXW52_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW52_RS01055	COG0444	Belongs to the ABC transporter superfamily
EXW52_RS01060	COG4608	Belongs to the ABC transporter superfamily
EXW52_RS01065	COG4166	transmembrane transport
EXW52_RS01080	COG4166	transmembrane transport
EXW52_RS01085	COG4166	transmembrane transport
EXW52_RS01090	COG0656	L-ascorbic acid biosynthetic process
EXW52_RS01095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW52_RS01110	COG4149	molybdate abc transporter
EXW52_RS01115	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW52_RS01120	COG1910	domain protein
EXW52_RS01135	COG0697	spore germination
EXW52_RS01150	COG0204	Acyl-transferase
EXW52_RS01160	COG1609	Transcriptional regulator
EXW52_RS01170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS01185	COG5298	Protein conserved in bacteria
EXW52_RS01205	COG0488	(ABC) transporter
EXW52_RS01210	COG4585	Histidine kinase
EXW52_RS01215	COG2197	response regulator
EXW52_RS01220	COG1131	(ABC) transporter
EXW52_RS01225	COG0842	Transport permease protein
EXW52_RS01225	COG1511	domain protein
EXW52_RS01230	COG0842	Transport permease protein
EXW52_RS01240	COG0747	negative chemotaxis
EXW52_RS01250	COG0601	transmembrane transport
EXW52_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW52_RS01260	COG0444	Belongs to the ABC transporter superfamily
EXW52_RS01265	COG4608	Belongs to the ABC transporter superfamily
EXW52_RS01270	COG0561	phosphatase activity
EXW52_RS01300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW52_RS01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW52_RS01315	COG0531	amino acid
EXW52_RS01320	COG2814	Major facilitator Superfamily
EXW52_RS01330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW52_RS01340	COG4294	response to UV
EXW52_RS01345	COG0705	Rhomboid family
EXW52_RS01350	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW52_RS01355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW52_RS01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW52_RS01365	COG0864	Transcriptional regulator
EXW52_RS01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW52_RS01375	COG2183	response to ionizing radiation
EXW52_RS01475	COG0802	atpase or kinase
EXW52_RS01480	COG1214	PFAM Peptidase M22, glycoprotease
EXW52_RS01485	COG0456	acetyltransferase
EXW52_RS01495	COG0488	(ABC) transporter
EXW52_RS01500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW52_RS01510	COG1266	CAAX protease self-immunity
EXW52_RS01515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW52_RS01520	COG0459	protein refolding
EXW52_RS01525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW52_RS01525	COG0519	Catalyzes the synthesis of GMP from XMP
EXW52_RS01530	COG2252	PERMEase
EXW52_RS01540	COG5002	protein histidine kinase activity
EXW52_RS01565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW52_RS01595	COG2226	methyltransferase
EXW52_RS01605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS01615	COG1215	transferase activity, transferring glycosyl groups
EXW52_RS01660	COG2205	protein histidine kinase activity
EXW52_RS01665	COG0745	RESPONSE REGULATOR receiver
EXW52_RS01685	COG0697	spore germination
EXW52_RS01710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW52_RS01715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW52_RS01720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW52_RS01725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW52_RS01730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW52_RS01735	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW52_RS01740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW52_RS01745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW52_RS01750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW52_RS01755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW52_RS01760	COG0138	bifunctional purine biosynthesis protein purh
EXW52_RS01765	COG0151	Belongs to the GarS family
EXW52_RS01785	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW52_RS01790	COG0210	DNA helicase
EXW52_RS01795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW52_RS01800	COG4851	CamS sex pheromone cAM373 precursor
EXW52_RS01810	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS01815	COG1335	isochorismatase
EXW52_RS01825	COG2011	ABC-type metal ion transport system permease component
EXW52_RS01845	COG0003	Pfam Anion-transporting ATPase
EXW52_RS01850	COG1846	Transcriptional regulator
EXW52_RS01855	COG4682	membrane
EXW52_RS01865	COG0154	amidase activity
EXW52_RS01870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW52_RS01875	COG1597	lipid kinase activity
EXW52_RS01885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW52_RS01895	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS01900	COG2076	Multidrug Resistance protein
EXW52_RS01905	COG2309	aminopeptidase activity
EXW52_RS01920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW52_RS01935	COG5002	protein histidine kinase activity
EXW52_RS01940	COG4807	Protein conserved in bacteria
EXW52_RS01965	COG1757	Na H antiporter
EXW52_RS01970	COG1473	amidohydrolase
EXW52_RS01990	COG0450	alkyl hydroperoxide reductase
EXW52_RS02000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW52_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS02015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS02020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS02025	COG0492	ferredoxin-NADP+ reductase activity
EXW52_RS02035	COG0166	Belongs to the GPI family
EXW52_RS02060	COG5002	protein histidine kinase activity
EXW52_RS02080	COG3541	Predicted nucleotidyltransferase
EXW52_RS02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW52_RS02085	COG0723	plastoquinol--plastocyanin reductase activity
EXW52_RS02095	COG0765	amino acid transport
EXW52_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW52_RS02110	COG0840	transmembrane signaling receptor activity
EXW52_RS02115	COG0277	FAD linked oxidase domain protein
EXW52_RS02120	COG0366	Alpha amylase catalytic
EXW52_RS02125	COG1263	PTS System
EXW52_RS02125	COG2190	(PTS) system
EXW52_RS02125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS02145	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW52_RS02155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW52_RS02170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW52_RS02175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW52_RS02180	COG1116	anion transmembrane transporter activity
EXW52_RS02185	COG0488	(ABC) transporter
EXW52_RS02230	COG2270	Major facilitator Superfamily
EXW52_RS02265	COG2310	stress, protein
EXW52_RS02270	COG2310	stress, protein
EXW52_RS02275	COG2310	stress, protein
EXW52_RS02280	COG0861	Integral membrane protein TerC family
EXW52_RS02290	COG3853	Toxic anion resistance protein (TelA)
EXW52_RS02300	COG4840	Belongs to the UPF0435 family
EXW52_RS02305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW52_RS02315	COG1295	ribonuclease BN
EXW52_RS02320	COG2217	Heavy metal translocating P-type atpase
EXW52_RS02325	COG0697	spore germination
EXW52_RS02345	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS02360	COG3871	stress protein (general stress protein 26)
EXW52_RS02365	COG0387	Pfam Sodium calcium exchanger
EXW52_RS02375	COG0535	radical SAM domain protein
EXW52_RS02395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW52_RS02415	COG3829	transcription factor binding
EXW52_RS02425	COG0833	amino acid
EXW52_RS02430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW52_RS02450	COG2066	Belongs to the glutaminase family
EXW52_RS02455	COG1263	PTS System
EXW52_RS02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS02460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS02475	COG1216	Glycosyl transferase, family 2
EXW52_RS02485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW52_RS02485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS02490	COG0463	Glycosyl transferase, family 2
EXW52_RS02505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW52_RS02510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW52_RS02525	COG1228	amidohydrolase
EXW52_RS02530	COG1090	epimerase
EXW52_RS02535	COG2137	regulation of response to DNA damage stimulus
EXW52_RS02560	COG1988	membrane-bound metal-dependent
EXW52_RS02565	COG1194	a g-specific adenine glycosylase
EXW52_RS02590	COG3557	Belongs to the UPF0374 family
EXW52_RS02595	COG1132	(ABC) transporter
EXW52_RS02600	COG4129	membrane
EXW52_RS02605	COG0067	glutamate synthase
EXW52_RS02605	COG0070	glutamate synthase
EXW52_RS02605	COG0069	glutamate synthase activity
EXW52_RS02610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW52_RS02615	COG4555	ABC transporter
EXW52_RS02635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW52_RS02640	COG0735	belongs to the Fur family
EXW52_RS02760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW52_RS02765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW52_RS02785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW52_RS02795	COG2766	serine protein kinase
EXW52_RS02800	COG2718	Belongs to the UPF0229 family
EXW52_RS02815	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW52_RS02820	COG2268	Band 7 protein
EXW52_RS02830	COG3290	protein histidine kinase activity
EXW52_RS02835	COG4565	transcriptional regulatory protein
EXW52_RS02840	COG2851	Citrate transporter
EXW52_RS02865	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW52_RS02870	COG3842	ATPase activity
EXW52_RS02875	COG1175	transmembrane transport
EXW52_RS02880	COG0395	ABC-type sugar transport system, permease component
EXW52_RS02890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW52_RS02895	COG0745	RESPONSE REGULATOR receiver
EXW52_RS02900	COG5002	protein histidine kinase activity
EXW52_RS02910	COG4990	cell redox homeostasis
EXW52_RS02920	COG3290	protein histidine kinase activity
EXW52_RS02925	COG4565	transcriptional regulatory protein
EXW52_RS02930	COG3493	citrate carrier protein
EXW52_RS02935	COG0281	malic enzyme
EXW52_RS02945	COG0697	spore germination
EXW52_RS02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS02960	COG5002	protein histidine kinase activity
EXW52_RS02965	COG0745	RESPONSE REGULATOR receiver
EXW52_RS02970	COG0456	acetyltransferase
EXW52_RS02975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW52_RS02980	COG3383	formate dehydrogenase (NAD+) activity
EXW52_RS02985	COG2427	Protein of unknown function (DUF1641)
EXW52_RS03000	COG0531	amino acid
EXW52_RS03010	COG0640	Transcriptional regulator
EXW52_RS03015	COG2217	Heavy metal translocating P-type atpase
EXW52_RS03020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW52_RS03035	COG3227	Zinc metalloprotease (Elastase)
EXW52_RS03055	COG2720	vancomycin resistance protein
EXW52_RS03060	COG1316	TRANSCRIPTIONal
EXW52_RS03065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS03070	COG0346	lactoylglutathione lyase activity
EXW52_RS03075	COG1253	flavin adenine dinucleotide binding
EXW52_RS03080	COG1027	Aspartate ammonia-lyase
EXW52_RS03085	COG1620	l-lactate permease
EXW52_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS03105	COG3104	oligopeptide transport
EXW52_RS03110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS03115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS03120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS03135	COG0156	8-amino-7-oxononanoate synthase activity
EXW52_RS03140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS03150	COG4548	von Willebrand factor, type A
EXW52_RS03155	COG0714	Associated with various cellular activities
EXW52_RS03175	COG0531	amino acid
EXW52_RS03180	COG2188	Transcriptional regulator
EXW52_RS03190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS03190	COG1263	PTS System
EXW52_RS03195	COG0366	Alpha amylase catalytic
EXW52_RS03210	COG0697	spore germination
EXW52_RS03215	COG4585	Histidine kinase
EXW52_RS03220	COG2197	response regulator
EXW52_RS03225	COG1404	Belongs to the peptidase S8 family
EXW52_RS03240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS03245	COG1115	amino acid carrier protein
EXW52_RS03250	COG1126	abc transporter atp-binding protein
EXW52_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW52_RS03260	COG0765	amino acid transport
EXW52_RS03265	COG0765	amino acid transport
EXW52_RS03270	COG0833	amino acid
EXW52_RS03300	COG2378	regulation of single-species biofilm formation
EXW52_RS03305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW52_RS03310	COG5002	protein histidine kinase activity
EXW52_RS03325	COG0659	secondary active sulfate transmembrane transporter activity
EXW52_RS03350	COG0601	transmembrane transport
EXW52_RS03355	COG4608	Belongs to the ABC transporter superfamily
EXW52_RS03365	COG2271	Major facilitator Superfamily
EXW52_RS03370	COG1846	Transcriptional regulator
EXW52_RS03375	COG0477	Major facilitator Superfamily
EXW52_RS03380	COG1609	Transcriptional regulator
EXW52_RS03385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW52_RS03390	COG1869	D-ribose catabolic process
EXW52_RS03400	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW52_RS03405	COG1879	ABC-type sugar transport system periplasmic component
EXW52_RS03435	COG1063	alcohol dehydrogenase
EXW52_RS03450	COG3568	Endonuclease Exonuclease Phosphatase
EXW52_RS03480	COG0840	transmembrane signaling receptor activity
EXW52_RS03485	COG3583	domain protein
EXW52_RS03485	COG3584	3D domain protein
EXW52_RS03490	COG1476	TRANSCRIPTIONal
EXW52_RS03510	COG3104	oligopeptide transport
EXW52_RS03515	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS03530	COG1113	amino acid transport
EXW52_RS03535	COG2252	PERMEase
EXW52_RS03550	COG2153	protein acetylation
EXW52_RS03560	COG0475	glutathione-regulated potassium exporter activity
EXW52_RS03560	COG0569	domain protein
EXW52_RS03570	COG1845	cytochrome c oxidase, subunit III
EXW52_RS03575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW52_RS03585	COG0833	amino acid
EXW52_RS03590	COG4990	cell redox homeostasis
EXW52_RS03605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW52_RS03610	COG0697	spore germination
EXW52_RS03615	COG0531	amino acid
EXW52_RS03625	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW52_RS03630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW52_RS03640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW52_RS03645	COG0573	inorganic phosphate transmembrane transporter activity
EXW52_RS03650	COG0581	inorganic phosphate transmembrane transporter activity
EXW52_RS03660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW52_RS03780	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW52_RS03795	COG3103	Sh3 type 3 domain protein
EXW52_RS03795	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS03795	COG4991	sh3 domain protein
EXW52_RS03800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW52_RS03805	COG1116	anion transmembrane transporter activity
EXW52_RS03810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW52_RS03815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW52_RS03820	COG0352	thiamine-phosphate diphosphorylase activity
EXW52_RS03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW52_RS03830	COG2104	thiamine diphosphate biosynthetic process
EXW52_RS03835	COG2022	thiamine diphosphate biosynthetic process
EXW52_RS03840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW52_RS03845	COG0351	phosphomethylpyrimidine kinase
EXW52_RS03870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW52_RS03875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW52_RS03880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW52_RS03885	COG2205	protein histidine kinase activity
EXW52_RS03890	COG2814	Major facilitator Superfamily
EXW52_RS03895	COG1846	Transcriptional regulator
EXW52_RS03905	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW52_RS03910	COG1129	ABC transporter
EXW52_RS03915	COG1879	ABC-type sugar transport system periplasmic component
EXW52_RS03920	COG2252	PERMEase
EXW52_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS03985	COG0778	Nitroreductase
EXW52_RS03990	COG2719	SpoVR family
EXW52_RS04015	COG1937	Protein conserved in bacteria
EXW52_RS04020	COG0425	Belongs to the sulfur carrier protein TusA family
EXW52_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS04030	COG0425	Belongs to the sulfur carrier protein TusA family
EXW52_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
EXW52_RS04040	COG2210	Belongs to the sulfur carrier protein TusA family
EXW52_RS04045	COG0730	response to heat
EXW52_RS04055	COG1316	TRANSCRIPTIONal
EXW52_RS04060	COG0604	alcohol dehydrogenase
EXW52_RS04065	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW52_RS04070	COG0604	alcohol dehydrogenase
EXW52_RS04075	COG2814	Major facilitator Superfamily
EXW52_RS04085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW52_RS04085	COG3711	transcriptional antiterminator
EXW52_RS04090	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW52_RS04095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW52_RS04115	COG1388	LysM domain
EXW52_RS04115	COG3584	3D domain protein
EXW52_RS04120	COG0577	efflux transmembrane transporter activity
EXW52_RS04125	COG1136	(ABC) transporter
EXW52_RS04135	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW52_RS04150	COG0577	efflux transmembrane transporter activity
EXW52_RS04155	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS04160	COG3546	catalase activity
EXW52_RS04190	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS04220	COG0531	amino acid
EXW52_RS04235	COG1737	Transcriptional regulator
EXW52_RS04240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW52_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS04245	COG1263	PTS System
EXW52_RS04255	COG2259	Doxx family
EXW52_RS04275	COG0697	spore germination
EXW52_RS04280	COG1522	sequence-specific DNA binding
EXW52_RS04290	COG0300	oxidoreductase activity
EXW52_RS04305	COG2076	Multidrug Resistance protein
EXW52_RS04310	COG1309	transcriptional regulator
EXW52_RS04315	COG2814	Major facilitator Superfamily
EXW52_RS04320	COG1733	regulation of RNA biosynthetic process
EXW52_RS04340	COG4533	DNA binding
EXW52_RS04345	COG2211	Major facilitator Superfamily
EXW52_RS04355	COG0693	protein deglycase activity
EXW52_RS04365	COG0531	amino acid
EXW52_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS04375	COG1132	(ABC) transporter
EXW52_RS04380	COG1132	(ABC) transporter
EXW52_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW52_RS04390	COG0765	amino acid transport
EXW52_RS04395	COG1126	abc transporter atp-binding protein
EXW52_RS04410	COG0189	ligase activity
EXW52_RS04420	COG4399	Belongs to the UPF0754 family
EXW52_RS04425	COG3679	Belongs to the UPF0342 family
EXW52_RS04440	COG0028	Belongs to the TPP enzyme family
EXW52_RS04445	COG3527	Alpha-acetolactate decarboxylase
EXW52_RS04450	COG0463	Glycosyl transferase, family 2
EXW52_RS04455	COG1216	Glycosyl transferase, family 2
EXW52_RS04460	COG2094	Belongs to the DNA glycosylase MPG family
EXW52_RS04465	COG0561	phosphatase activity
EXW52_RS04475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW52_RS04480	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS04490	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS04500	COG0789	Transcriptional regulator
EXW52_RS04500	COG4978	Transcriptional regulator
EXW52_RS04510	COG0659	secondary active sulfate transmembrane transporter activity
EXW52_RS04525	COG0653	protein targeting
EXW52_RS04530	COG2244	polysaccharide biosynthetic process
EXW52_RS04540	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS04545	COG4196	transglutaminase domain protein
EXW52_RS04565	COG1024	Enoyl-CoA hydratase
EXW52_RS04580	COG1363	Peptidase, m42
EXW52_RS04595	COG2318	DinB family
EXW52_RS04615	COG0579	oxidoreductase
EXW52_RS04650	COG0601	transmembrane transport
EXW52_RS04655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW52_RS04660	COG0444	Belongs to the ABC transporter superfamily
EXW52_RS04665	COG4608	Belongs to the ABC transporter superfamily
EXW52_RS04690	COG0477	Major facilitator Superfamily
EXW52_RS04695	COG3290	protein histidine kinase activity
EXW52_RS04700	COG4565	transcriptional regulatory protein
EXW52_RS04705	COG3181	Tripartite tricarboxylate transporter family receptor
EXW52_RS04735	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EXW52_RS04785	COG0305	Participates in initiation and elongation during chromosome replication
EXW52_RS04810	COG1842	Phage shock protein A
EXW52_RS04825	COG0477	Major facilitator Superfamily
EXW52_RS04865	COG1183	phosphatidylcholine synthase activity
EXW52_RS04920	COG2732	(Barnase) inhibitor
EXW52_RS04925	COG2814	Major facilitator Superfamily
EXW52_RS04930	COG0640	Transcriptional regulator
EXW52_RS04950	COG2376	Dihydroxyacetone kinase
EXW52_RS04965	COG2376	Dihydroxyacetone kinase
EXW52_RS04975	COG1959	2 iron, 2 sulfur cluster binding
EXW52_RS04995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW52_RS05010	COG2720	vancomycin resistance protein
EXW52_RS05040	COG0076	glutamate decarboxylase activity
EXW52_RS05055	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS05055	COG1525	nuclease
EXW52_RS05055	COG4085	toxin activity
EXW52_RS05090	COG0825	malonyl-CoA metabolic process
EXW52_RS05115	COG2807	transmembrane transport
EXW52_RS05120	COG2186	Transcriptional regulator
EXW52_RS05130	COG4585	Histidine kinase
EXW52_RS05135	COG2197	response regulator
EXW52_RS05165	COG0420	3'-5' exonuclease activity
EXW52_RS05170	COG4717	serine-type aminopeptidase activity
EXW52_RS05175	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW52_RS05220	COG0346	lactoylglutathione lyase activity
EXW52_RS05225	COG0346	lactoylglutathione lyase activity
EXW52_RS05230	COG0457	Tetratricopeptide repeat
EXW52_RS05240	COG2267	carboxylic ester hydrolase activity
EXW52_RS05255	COG3620	sequence-specific DNA binding
EXW52_RS05260	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW52_RS05265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW52_RS05270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW52_RS05275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW52_RS05280	COG1595	DNA-templated transcription, initiation
EXW52_RS05295	COG3973	AAA domain
EXW52_RS05300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW52_RS05315	COG1846	Transcriptional regulator
EXW52_RS05325	COG0537	adenosine 5'-monophosphoramidase activity
EXW52_RS05330	COG1131	(ABC) transporter
EXW52_RS05335	COG4473	ABC transporter
EXW52_RS05345	COG0247	lactate metabolic process
EXW52_RS05350	COG1139	Iron-sulfur cluster binding protein
EXW52_RS05355	COG1556	Lactate utilization protein
EXW52_RS05370	COG3402	PFAM membrane-flanked domain
EXW52_RS05375	COG3428	Bacterial PH domain
EXW52_RS05415	COG3402	PFAM membrane-flanked domain
EXW52_RS05420	COG3428	Bacterial PH domain
EXW52_RS05425	COG2329	Antibiotic biosynthesis monooxygenase
EXW52_RS05430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW52_RS05435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW52_RS05440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW52_RS05445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW52_RS05475	COG1309	transcriptional regulator
EXW52_RS05480	COG1511	domain protein
EXW52_RS05515	COG2378	regulation of single-species biofilm formation
EXW52_RS05520	COG1609	Transcriptional regulator
EXW52_RS05530	COG1234	tRNA 3'-trailer cleavage
EXW52_RS05535	COG0095	Lipoate-protein ligase
EXW52_RS05545	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS05560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW52_RS05570	COG4208	sulfate ABC transporter
EXW52_RS05610	COG1408	metallophosphoesterase
EXW52_RS05615	COG1078	dGTPase activity
EXW52_RS05630	COG1595	DNA-templated transcription, initiation
EXW52_RS05635	COG2207	Transcriptional regulator
EXW52_RS05635	COG3708	Transcriptional regulator
EXW52_RS05640	COG2205	protein histidine kinase activity
EXW52_RS05645	COG0745	RESPONSE REGULATOR receiver
EXW52_RS05660	COG0501	Belongs to the peptidase M48B family
EXW52_RS05665	COG0697	spore germination
EXW52_RS05690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW52_RS05695	COG2224	Isocitrate lyase
EXW52_RS05705	COG1278	Cold shock
EXW52_RS05715	COG4903	ComK protein
EXW52_RS05725	COG0398	Pfam SNARE associated Golgi protein
EXW52_RS05735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW52_RS05740	COG1074	ATP-dependent DNA helicase activity
EXW52_RS05790	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW52_RS05815	COG0367	asparagine synthase
EXW52_RS05825	COG0753	catalase activity
EXW52_RS05830	COG0004	ammonium transporteR
EXW52_RS05840	COG1666	GTP binding
EXW52_RS05845	COG2996	Protein conserved in bacteria
EXW52_RS05860	COG1329	Transcriptional regulator
EXW52_RS05890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW52_RS05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS05915	COG0561	phosphatase activity
EXW52_RS05935	COG2267	carboxylic ester hydrolase activity
EXW52_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW52_RS05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW52_RS05960	COG5504	Zn-dependent protease
EXW52_RS05975	COG0180	Tryptophanyl-tRNA synthetase
EXW52_RS05985	COG4166	transmembrane transport
EXW52_RS05990	COG0601	transmembrane transport
EXW52_RS05995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW52_RS06000	COG0444	Belongs to the ABC transporter superfamily
EXW52_RS06005	COG4608	Belongs to the ABC transporter superfamily
EXW52_RS06010	COG0534	Mate efflux family protein
EXW52_RS06015	COG4166	transmembrane transport
EXW52_RS06030	COG0861	Integral membrane protein TerC family
EXW52_RS06035	COG4862	establishment of competence for transformation
EXW52_RS06040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW52_RS06050	COG1164	Oligoendopeptidase f
EXW52_RS06065	COG2346	COG2346, Truncated hemoglobins
EXW52_RS06070	COG4116	CYTH
EXW52_RS06080	COG2357	RelA SpoT domain protein
EXW52_RS06090	COG0564	pseudouridine synthase activity
EXW52_RS06100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW52_RS06105	COG0772	Belongs to the SEDS family
EXW52_RS06110	COG1216	Glycosyl transferase, family 2
EXW52_RS06130	COG0457	Tetratricopeptide repeat
EXW52_RS06130	COG0463	Glycosyl transferase, family 2
EXW52_RS06150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW52_RS06165	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW52_RS06210	COG2153	protein acetylation
EXW52_RS06215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW52_RS06220	COG2382	esterase
EXW52_RS06245	COG5492	domain, Protein
EXW52_RS06250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW52_RS06260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW52_RS06260	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW52_RS06265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW52_RS06270	COG0134	indole-3-glycerol-phosphate synthase activity
EXW52_RS06275	COG0135	phosphoribosylanthranilate isomerase activity
EXW52_RS06280	COG0133	tryptophan synthase activity
EXW52_RS06285	COG0159	tryptophan synthase activity
EXW52_RS06295	COG1620	l-lactate permease
EXW52_RS06300	COG5634	Uncharacterized conserved protein (DUF2278)
EXW52_RS06340	COG2226	methyltransferase
EXW52_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW52_RS06365	COG0567	Dehydrogenase, E1 component
EXW52_RS06370	COG1476	TRANSCRIPTIONal
EXW52_RS06395	COG4152	abc transporter atp-binding protein
EXW52_RS06400	COG1668	transmembrane transport
EXW52_RS06420	COG1686	Belongs to the peptidase S11 family
EXW52_RS06425	COG0681	Belongs to the peptidase S26 family
EXW52_RS06460	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS06470	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW52_RS06475	COG1177	transmembrane transport
EXW52_RS06480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW52_RS06490	COG2409	Drug exporters of the RND superfamily
EXW52_RS06500	COG0564	pseudouridine synthase activity
EXW52_RS06510	COG2340	Cysteine-rich secretory protein family
EXW52_RS06515	COG0247	lactate metabolic process
EXW52_RS06520	COG0277	FAD linked oxidase domain protein
EXW52_RS06525	COG3835	regulator
EXW52_RS06535	COG0745	RESPONSE REGULATOR receiver
EXW52_RS06540	COG5002	protein histidine kinase activity
EXW52_RS06545	COG2186	Transcriptional regulator
EXW52_RS06550	COG0247	lactate metabolic process
EXW52_RS06555	COG1139	Iron-sulfur cluster binding protein
EXW52_RS06560	COG1556	Lactate utilization protein
EXW52_RS06565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW52_RS06575	COG2116	formate transmembrane transporter activity
EXW52_RS06580	COG0861	Integral membrane protein TerC family
EXW52_RS06585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW52_RS06595	COG2030	dehydratase
EXW52_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS06620	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW52_RS06630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW52_RS06645	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW52_RS06650	COG3842	ATPase activity
EXW52_RS06660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW52_RS06665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW52_RS06675	COG1349	DNA-binding transcription factor activity
EXW52_RS06685	COG0235	Class ii aldolase
EXW52_RS06695	COG2861	carbohydrate metabolic process
EXW52_RS06705	COG3852	Histidine kinase
EXW52_RS06710	COG1846	Transcriptional regulator
EXW52_RS06720	COG2318	DinB family
EXW52_RS06725	COG5002	protein histidine kinase activity
EXW52_RS06730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW52_RS06735	COG0720	synthase
EXW52_RS06745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW52_RS06750	COG4873	Protein conserved in bacteria
EXW52_RS06765	COG0456	acetyltransferase
EXW52_RS06780	COG1780	Probably involved in ribonucleotide reductase function
EXW52_RS06795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW52_RS06800	COG0531	amino acid
EXW52_RS06805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW52_RS06820	COG2204	response regulator
EXW52_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS06840	COG1725	Transcriptional regulator
EXW52_RS06845	COG1131	(ABC) transporter
EXW52_RS06855	COG1131	(ABC) transporter
EXW52_RS06860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW52_RS06865	COG1266	CAAX protease self-immunity
EXW52_RS06875	COG1522	sequence-specific DNA binding
EXW52_RS06885	COG1335	isochorismatase
EXW52_RS06895	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW52_RS06900	COG2070	2-Nitropropane dioxygenase
EXW52_RS06905	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW52_RS06910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW52_RS06915	COG1696	Membrane protein involved in D-alanine export
EXW52_RS06920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW52_RS06940	COG0716	FMN binding
EXW52_RS06975	COG0534	Mate efflux family protein
EXW52_RS06995	COG1846	Transcriptional regulator
EXW52_RS07005	COG1301	dicarboxylic acid transport
EXW52_RS07010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW52_RS07020	COG3874	Sporulation protein YtfJ
EXW52_RS07040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW52_RS07045	COG0028	Belongs to the TPP enzyme family
EXW52_RS07050	COG0440	acetolactate synthase activity
EXW52_RS07060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW52_RS07070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW52_RS07080	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW52_RS07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW52_RS07095	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW52_RS07100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW52_RS07105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW52_RS07110	COG0107	imidazoleglycerol-phosphate synthase activity
EXW52_RS07120	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW52_RS07125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW52_RS07140	COG1183	phosphatidylcholine synthase activity
EXW52_RS07145	COG1368	sulfuric ester hydrolase activity
EXW52_RS07155	COG0019	diaminopimelate decarboxylase activity
EXW52_RS07165	COG0175	sulfate reduction
EXW52_RS07170	COG2046	Belongs to the sulfate adenylyltransferase family
EXW52_RS07175	COG0529	Catalyzes the synthesis of activated sulfate
EXW52_RS07180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW52_RS07200	COG1648	precorrin-2 dehydrogenase activity
EXW52_RS07205	COG0733	neurotransmitter:sodium symporter activity
EXW52_RS07230	COG1757	Na H antiporter
EXW52_RS07250	COG4758	membrane
EXW52_RS07255	COG4585	Histidine kinase
EXW52_RS07260	COG2197	response regulator
EXW52_RS07270	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS07280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW52_RS07320	COG0730	response to heat
EXW52_RS07325	COG0306	phosphate transporter
EXW52_RS07330	COG1392	Phosphate transport regulator
EXW52_RS07335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW52_RS07350	COG3852	Histidine kinase
EXW52_RS07355	COG1801	Protein of unknown function DUF72
EXW52_RS07365	COG0582	viral genome integration into host DNA
EXW52_RS07370	COG5002	protein histidine kinase activity
EXW52_RS07385	COG0392	lysyltransferase activity
EXW52_RS07385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW52_RS07400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW52_RS07405	COG1686	Belongs to the peptidase S11 family
EXW52_RS07410	COG2715	membrane protein required for spore maturation
EXW52_RS07415	COG0700	Nucleoside recognition
EXW52_RS07420	COG1187	pseudouridine synthase activity
EXW52_RS07430	COG1333	cytochrome c biogenesis protein
EXW52_RS07435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW52_RS07440	COG0745	RESPONSE REGULATOR receiver
EXW52_RS07445	COG5002	protein histidine kinase activity
EXW52_RS07450	COG2096	Adenosyltransferase
EXW52_RS07455	COG4942	peptidase
EXW52_RS07465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW52_RS07470	COG1141	Ferredoxin
EXW52_RS07475	COG4955	Helix-turn-helix domain
EXW52_RS07480	COG0514	ATP-dependent DNA helicase (RecQ)
EXW52_RS07485	COG1266	CAAX protease self-immunity
EXW52_RS07495	COG1408	metallophosphoesterase
EXW52_RS07510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW52_RS07530	COG0492	ferredoxin-NADP+ reductase activity
EXW52_RS07535	COG0252	asparaginase activity
EXW52_RS07545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW52_RS07555	COG1304	FMN binding
EXW52_RS07585	COG1160	GTP binding
EXW52_RS07590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW52_RS07610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW52_RS07620	COG0302	gtp cyclohydrolase
EXW52_RS07625	COG0142	geranyltranstransferase activity
EXW52_RS07630	COG2226	methyltransferase
EXW52_RS07635	COG0142	geranyltranstransferase activity
EXW52_RS07650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW52_RS07660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW52_RS07665	COG0457	Tetratricopeptide repeat
EXW52_RS07670	COG5582	Belongs to the UPF0302 family
EXW52_RS07685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW52_RS07700	COG4347	Protein of unknown function (DUF1405)
EXW52_RS07715	COG2738	Putative neutral zinc metallopeptidase
EXW52_RS07725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS07730	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW52_RS07735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW52_RS07740	COG1803	Methylglyoxal synthase
EXW52_RS07745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW52_RS07750	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS07755	COG0617	tRNA 3'-terminal CCA addition
EXW52_RS07765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW52_RS07770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW52_RS07780	COG1199	ATP-dependent helicase activity
EXW52_RS07780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW52_RS07800	COG3935	DnaD domain protein
EXW52_RS07805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW52_RS07815	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW52_RS07815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW52_RS07820	COG3331	DNA recombination
EXW52_RS07855	COG4474	Belongs to the UPF0398 family
EXW52_RS07860	COG3599	regulation of cell shape
EXW52_RS07870	COG0116	Belongs to the methyltransferase superfamily
EXW52_RS07880	COG1199	ATP-dependent helicase activity
EXW52_RS07885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW52_RS07895	COG0024	Methionine aminopeptidase
EXW52_RS07905	COG2233	PERMEase
EXW52_RS07910	COG2311	Membrane
EXW52_RS07915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW52_RS07925	COG0456	acetyltransferase
EXW52_RS07935	COG2897	thiosulfate sulfurtransferase activity
EXW52_RS07975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW52_RS07990	COG0454	-acetyltransferase
EXW52_RS08010	COG0328	RNA-DNA hybrid ribonuclease activity
EXW52_RS08045	COG3403	YqcI/YcgG family
EXW52_RS08050	COG1280	lysine exporter protein (LysE YggA)
EXW52_RS08065	COG3162	membrane
EXW52_RS08070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW52_RS08075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW52_RS08085	COG0475	glutathione-regulated potassium exporter activity
EXW52_RS08090	COG4978	Transcriptional regulator
EXW52_RS08090	COG0789	Transcriptional regulator
EXW52_RS08100	COG2323	membrane
EXW52_RS08105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW52_RS08150	COG1923	regulation of RNA biosynthetic process
EXW52_RS08160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW52_RS08165	COG1360	Flagellar Motor Protein
EXW52_RS08170	COG2201	protein-glutamate methylesterase activity
EXW52_RS08175	COG0643	Histidine kinase
EXW52_RS08175	COG2198	Histidine kinase
EXW52_RS08180	COG1776	CheC inhibitor of MCP methylation
EXW52_RS08180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW52_RS08195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW52_RS08215	COG1256	bacterial-type flagellum assembly
EXW52_RS08220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW52_RS08240	COG1815	bacterial-type flagellum-dependent cell motility
EXW52_RS08245	COG1558	bacterial-type flagellum-dependent cell motility
EXW52_RS08255	COG1766	The M ring may be actively involved in energy transduction
EXW52_RS08260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW52_RS08270	COG1157	protein secretion by the type III secretion system
EXW52_RS08290	COG1749	Flagellar hook protein flgE
EXW52_RS08305	COG0835	chemotaxis
EXW52_RS08305	COG0784	Response regulator, receiver
EXW52_RS08325	COG0861	Integral membrane protein TerC family
EXW52_RS08335	COG3383	formate dehydrogenase (NAD+) activity
EXW52_RS08340	COG2427	Protein of unknown function (DUF1641)
EXW52_RS08345	COG5609	conserved protein (DUF2294)
EXW52_RS08350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW52_RS08360	COG2116	formate transmembrane transporter activity
EXW52_RS08365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW52_RS08370	COG0303	'Molybdopterin
EXW52_RS08375	COG0314	molybdopterin synthase activity
EXW52_RS08390	COG0489	protein tyrosine kinase activity
EXW52_RS08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW52_RS08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW52_RS08400	COG0741	lytic transglycosylase activity
EXW52_RS08410	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW52_RS08415	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW52_RS08415	COG1776	CheC inhibitor of MCP methylation
EXW52_RS08425	COG1338	Plays a role in the flagellum-specific transport system
EXW52_RS08430	COG1987	bacterial-type flagellum assembly
EXW52_RS08440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW52_RS08445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW52_RS08450	COG1419	protein localization to endoplasmic reticulum
EXW52_RS08455	COG4786	Flagellar basal body rod
EXW52_RS08460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW52_RS08505	COG2329	Antibiotic biosynthesis monooxygenase
EXW52_RS08530	COG0583	DNA-binding transcription factor activity
EXW52_RS08535	COG3842	ATPase activity
EXW52_RS08585	COG0406	alpha-ribazole phosphatase activity
EXW52_RS08615	COG0367	asparagine synthase
EXW52_RS08645	COG1802	Transcriptional regulator
EXW52_RS08650	COG0697	spore germination
EXW52_RS08655	COG1216	Glycosyl transferase, family 2
EXW52_RS08655	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS08660	COG1757	Na H antiporter
EXW52_RS08665	COG0789	Transcriptional regulator
EXW52_RS08670	COG4221	oxidoreductase activity
EXW52_RS08705	COG0534	Mate efflux family protein
EXW52_RS08710	COG3340	Belongs to the peptidase S51 family
EXW52_RS08730	COG0785	Cytochrome C biogenesis protein
EXW52_RS08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS08750	COG3048	D-serine ammonia-lyase activity
EXW52_RS08755	COG2733	membrane
EXW52_RS08790	COG1131	(ABC) transporter
EXW52_RS08810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW52_RS08815	COG0528	UMP kinase activity
EXW52_RS08825	COG1027	Aspartate ammonia-lyase
EXW52_RS08830	COG0281	malic enzyme
EXW52_RS08835	COG4191	Histidine kinase
EXW52_RS08840	COG0784	Response regulator, receiver
EXW52_RS08845	COG1846	Transcriptional regulator
EXW52_RS08855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW52_RS08865	COG2502	aspartate--ammonia ligase
EXW52_RS08870	COG3620	sequence-specific DNA binding
EXW52_RS08915	COG2814	Major facilitator Superfamily
EXW52_RS08945	COG0477	Major facilitator Superfamily
EXW52_RS08965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW52_RS08970	COG2223	nitrite transmembrane transporter activity
EXW52_RS08975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW52_RS08990	COG2244	polysaccharide biosynthetic process
EXW52_RS08995	COG0733	neurotransmitter:sodium symporter activity
EXW52_RS09005	COG5566	PFAM Mor transcription activator
EXW52_RS09010	COG2323	membrane
EXW52_RS09030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW52_RS09035	COG2132	Multicopper oxidase
EXW52_RS09045	COG5002	protein histidine kinase activity
EXW52_RS09050	COG0745	RESPONSE REGULATOR receiver
EXW52_RS09060	COG0129	dihydroxy-acid dehydratase activity
EXW52_RS09065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW52_RS09090	COG2814	Major facilitator Superfamily
EXW52_RS09095	COG3384	dioxygenase
EXW52_RS09150	COG4166	transmembrane transport
EXW52_RS09185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS09205	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW52_RS09210	COG1054	Belongs to the UPF0176 family
EXW52_RS09220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW52_RS09225	COG0531	amino acid
EXW52_RS09260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW52_RS09275	COG4257	antibiotic catabolic process
EXW52_RS09280	COG2390	Transcriptional regulator
EXW52_RS09290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW52_RS09295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS09300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW52_RS09315	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW52_RS09330	COG0583	DNA-binding transcription factor activity
EXW52_RS09345	COG0006	proline dipeptidase activity
EXW52_RS09350	COG2132	Multicopper oxidase
EXW52_RS09360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW52_RS09370	COG0583	DNA-binding transcription factor activity
EXW52_RS09390	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS09400	COG1834	amidinotransferase
EXW52_RS09410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS09420	COG2372	response to copper ion
EXW52_RS09420	COG1276	copper resistance
EXW52_RS09425	COG4549	nuclear export factor GLE1
EXW52_RS09435	COG0697	spore germination
EXW52_RS09440	COG0583	DNA-binding transcription factor activity
EXW52_RS09445	COG1959	2 iron, 2 sulfur cluster binding
EXW52_RS09450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW52_RS09455	COG0778	Nitroreductase
EXW52_RS09470	COG0628	permease
EXW52_RS09485	COG1231	oxidoreductase activity
EXW52_RS09490	COG0523	cobalamin synthesis protein
EXW52_RS09500	COG0411	ABC transporter
EXW52_RS09520	COG0583	DNA-binding transcription factor activity
EXW52_RS09530	COG1942	4-Oxalocrotonate Tautomerase
EXW52_RS09545	COG0346	lactoylglutathione lyase activity
EXW52_RS09555	COG1271	oxidase subunit
EXW52_RS09560	COG1294	oxidase, subunit
EXW52_RS09565	COG4988	ABC transporter
EXW52_RS09570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW52_RS09600	COG1686	Belongs to the peptidase S11 family
EXW52_RS09615	COG1388	LysM domain
EXW52_RS09615	COG0791	NLP P60 protein
EXW52_RS09625	COG1132	(ABC) transporter
EXW52_RS09630	COG0745	RESPONSE REGULATOR receiver
EXW52_RS09635	COG5002	protein histidine kinase activity
EXW52_RS09640	COG0300	oxidoreductase activity
EXW52_RS09645	COG4122	O-methyltransferase activity
EXW52_RS09660	COG5658	integral membrane protein
EXW52_RS09675	COG0460	homoserine dehydrogenase
EXW52_RS09685	COG0083	homoserine kinase activity
EXW52_RS09700	COG1316	TRANSCRIPTIONal
EXW52_RS09710	COG0745	RESPONSE REGULATOR receiver
EXW52_RS09715	COG5002	protein histidine kinase activity
EXW52_RS09735	COG1285	pathogenesis
EXW52_RS09740	COG1247	-acetyltransferase
EXW52_RS09760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW52_RS09770	COG1082	Xylose isomerase domain protein TIM barrel
EXW52_RS09780	COG2814	Major facilitator Superfamily
EXW52_RS09785	COG1279	arginine transmembrane transporter activity
EXW52_RS09790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS09800	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW52_RS09830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW52_RS09835	COG0577	efflux transmembrane transporter activity
EXW52_RS09840	COG2002	toxin-antitoxin pair type II binding
EXW52_RS09845	COG1404	Belongs to the peptidase S8 family
EXW52_RS09850	COG0640	Transcriptional regulator
EXW52_RS09855	COG0667	Aldo Keto reductase
EXW52_RS09895	COG3949	Membrane
EXW52_RS09900	COG0783	Belongs to the Dps family
EXW52_RS09915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW52_RS09925	COG1231	oxidoreductase activity
EXW52_RS09930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS09935	COG4989	oxidoreductase activity
EXW52_RS09940	COG0523	cobalamin synthesis protein
EXW52_RS09945	COG0456	acetyltransferase
EXW52_RS09950	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW52_RS09965	COG1902	pentaerythritol trinitrate reductase activity
EXW52_RS09970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW52_RS09980	COG4166	transmembrane transport
EXW52_RS09985	COG0346	lactoylglutathione lyase activity
EXW52_RS09995	COG0406	alpha-ribazole phosphatase activity
EXW52_RS10005	COG5337	Spore coat protein CotH
EXW52_RS10010	COG1051	belongs to the nudix hydrolase family
EXW52_RS10015	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS10020	COG2244	polysaccharide biosynthetic process
EXW52_RS10030	COG0701	Predicted permease
EXW52_RS10035	COG3689	TIGRFAM TIGR03943 family protein
EXW52_RS10040	COG1607	acyl-coa hydrolase
EXW52_RS10050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW52_RS10065	COG0702	epimerase
EXW52_RS10070	COG2839	Protein conserved in bacteria
EXW52_RS10075	COG1253	flavin adenine dinucleotide binding
EXW52_RS10100	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW52_RS10120	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS10130	COG1876	peptidase activity
EXW52_RS10135	COG0494	nUDIX hydrolase
EXW52_RS10160	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS10170	COG0561	phosphatase activity
EXW52_RS10175	COG1846	Transcriptional regulator
EXW52_RS10180	COG2814	Major facilitator Superfamily
EXW52_RS10190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW52_RS10195	COG4106	trans-aconitate 2-methyltransferase activity
EXW52_RS10210	COG1819	glycosyl
EXW52_RS10215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS10220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS10245	COG0456	acetyltransferase
EXW52_RS10340	COG3874	Sporulation protein YtfJ
EXW52_RS10365	COG2226	methyltransferase
EXW52_RS10395	COG0604	alcohol dehydrogenase
EXW52_RS10400	COG1595	DNA-templated transcription, initiation
EXW52_RS10420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW52_RS10420	COG0426	domain, Protein
EXW52_RS10430	COG0386	Belongs to the glutathione peroxidase family
EXW52_RS10435	COG1305	Transglutaminase-like
EXW52_RS10440	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW52_RS10445	COG0714	Associated with various cellular activities
EXW52_RS10450	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW52_RS10455	COG1140	nitrate reductase beta subunit
EXW52_RS10460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW52_RS10465	COG2181	nitrate reductase activity
EXW52_RS10470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW52_RS10475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW52_RS10480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW52_RS10485	COG0303	'Molybdopterin
EXW52_RS10490	COG0314	molybdopterin synthase activity
EXW52_RS10500	COG2223	nitrite transmembrane transporter activity
EXW52_RS10520	COG1648	precorrin-2 dehydrogenase activity
EXW52_RS10530	COG1587	Uroporphyrinogen-III synthase
EXW52_RS10530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW52_RS10535	COG2146	nitrite reductase [NAD(P)H] activity
EXW52_RS10540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW52_RS10545	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW52_RS10580	COG2359	stage V sporulation protein S
EXW52_RS10600	COG5444	nuclease activity
EXW52_RS10615	COG1418	mRNA catabolic process
EXW52_RS10620	COG0488	(ABC) transporter
EXW52_RS10650	COG1413	lyase activity
EXW52_RS10665	COG2136	Putative SAM-dependent methyltransferase
EXW52_RS10665	COG2521	methyltransferase
EXW52_RS10670	COG0018	arginyl-trna synthetase
EXW52_RS10715	COG0017	Asparaginyl-tRNA synthetase
EXW52_RS10735	COG1674	ftsk spoiiie
EXW52_RS10770	COG5444	nuclease activity
EXW52_RS10805	COG0733	neurotransmitter:sodium symporter activity
EXW52_RS10830	COG2610	gluconate transmembrane transporter activity
EXW52_RS10840	COG1794	racemase activity, acting on amino acids and derivatives
EXW52_RS10850	COG0456	acetyltransferase
EXW52_RS10855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW52_RS10860	COG1131	(ABC) transporter
EXW52_RS10865	COG4473	ABC transporter
EXW52_RS10875	COG0546	phosphoglycolate phosphatase activity
EXW52_RS10915	COG0768	penicillin binding
EXW52_RS10930	COG1272	protein, Hemolysin III
EXW52_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW52_RS10940	COG0805	protein transport
EXW52_RS10950	COG1307	EDD domain protein, DegV family
EXW52_RS10955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW52_RS10960	COG1999	signal sequence binding
EXW52_RS10965	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW52_RS10970	COG0367	asparagine synthase
EXW52_RS10985	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS10990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS10995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW52_RS11045	COG1335	isochorismatase
EXW52_RS11055	COG0668	transmembrane transport
EXW52_RS11060	COG2203	Gaf domain
EXW52_RS11060	COG4585	Histidine kinase
EXW52_RS11065	COG2197	response regulator
EXW52_RS11070	COG1737	Transcriptional regulator
EXW52_RS11075	COG1064	alcohol dehydrogenase
EXW52_RS11090	COG1070	Carbohydrate kinase
EXW52_RS11100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW52_RS11120	COG1125	glycine betaine transport
EXW52_RS11120	COG0517	IMP dehydrogenase activity
EXW52_RS11125	COG1174	glycine betaine transport
EXW52_RS11160	COG1253	flavin adenine dinucleotide binding
EXW52_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS11170	COG5506	Protein of unknown function (DUF1694)
EXW52_RS11185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW52_RS11190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW52_RS11195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW52_RS11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW52_RS11205	COG0456	acetyltransferase
EXW52_RS11210	COG3829	transcription factor binding
EXW52_RS11215	COG1509	lysine 2,3-aminomutase activity
EXW52_RS11225	COG4479	Belongs to the UPF0346 family
EXW52_RS11250	COG4991	sh3 domain protein
EXW52_RS11250	COG0515	serine threonine protein kinase
EXW52_RS11250	COG3064	Membrane
EXW52_RS11260	COG0671	phosphoesterase, PA-phosphatase related
EXW52_RS11265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW52_RS11270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS11340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW52_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS11385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW52_RS11385	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW52_RS11395	COG2814	Major facilitator Superfamily
EXW52_RS11405	COG0372	Belongs to the citrate synthase family
EXW52_RS11410	COG2079	MmgE PrpD family protein
EXW52_RS11415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW52_RS11420	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS11425	COG2084	Dehydrogenase
EXW52_RS11430	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS11435	COG1280	lysine exporter protein (LysE YggA)
EXW52_RS11440	COG1024	Enoyl-CoA hydratase
EXW52_RS11455	COG0420	3'-5' exonuclease activity
EXW52_RS11480	COG2223	nitrite transmembrane transporter activity
EXW52_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS11490	COG1169	isochorismate synthase
EXW52_RS11495	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW52_RS11500	COG1535	isochorismatase
EXW52_RS11500	COG3433	isochorismatase activity
EXW52_RS11505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW52_RS11510	COG3251	PFAM MbtH domain protein
EXW52_RS11515	COG2814	Major facilitator Superfamily
EXW52_RS11530	COG0776	regulation of translation
EXW52_RS11540	COG2318	DinB family
EXW52_RS11545	COG1115	amino acid carrier protein
EXW52_RS11560	COG2329	Antibiotic biosynthesis monooxygenase
EXW52_RS11570	COG1187	pseudouridine synthase activity
EXW52_RS11575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW52_RS11580	COG3655	Transcriptional regulator
EXW52_RS11590	COG1136	(ABC) transporter
EXW52_RS11600	COG2814	Major facilitator Superfamily
EXW52_RS11615	COG0028	Belongs to the TPP enzyme family
EXW52_RS11635	COG1253	flavin adenine dinucleotide binding
EXW52_RS11670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW52_RS11690	COG1846	Transcriptional regulator
EXW52_RS11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS11705	COG1309	transcriptional regulator
EXW52_RS11735	COG1247	-acetyltransferase
EXW52_RS11765	COG0596	Alpha beta hydrolase
EXW52_RS11770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW52_RS11780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS11810	COG0583	DNA-binding transcription factor activity
EXW52_RS11815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW52_RS11870	COG0583	DNA-binding transcription factor activity
EXW52_RS11875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW52_RS11880	COG2258	MOSC domain
EXW52_RS11895	COG1132	(ABC) transporter
EXW52_RS11900	COG1132	(ABC) transporter
EXW52_RS11920	COG1396	sequence-specific DNA binding
EXW52_RS11950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW52_RS11960	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW52_RS11965	COG1595	DNA-templated transcription, initiation
EXW52_RS11990	COG1649	PFAM Uncharacterised BCR, COG1649
EXW52_RS12010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW52_RS12015	COG2971	BadF BadG BcrA BcrD
EXW52_RS12025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW52_RS12070	COG0500	methyltransferase
EXW52_RS12070	COG3615	Tellurite resistance protein tehB
EXW52_RS12080	COG0693	protein deglycase activity
EXW52_RS12090	COG0588	phosphoglycerate mutase activity
EXW52_RS12130	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW52_RS12140	COG0110	maltose O-acetyltransferase activity
EXW52_RS12145	COG1136	(ABC) transporter
EXW52_RS12170	COG1686	Belongs to the peptidase S11 family
EXW52_RS12195	COG0768	penicillin binding
EXW52_RS12200	COG0745	RESPONSE REGULATOR receiver
EXW52_RS12205	COG2205	protein histidine kinase activity
EXW52_RS12210	COG1136	(ABC) transporter
EXW52_RS12215	COG0577	efflux transmembrane transporter activity
EXW52_RS12225	COG1595	DNA-templated transcription, initiation
EXW52_RS12235	COG0768	penicillin binding
EXW52_RS12240	COG0768	penicillin binding
EXW52_RS12275	COG1252	NADH dehydrogenase
EXW52_RS12280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS12280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS12295	COG0697	spore germination
EXW52_RS12325	COG3397	chitin binding
EXW52_RS12330	COG0823	Involved in the tonB-independent uptake of proteins
EXW52_RS12340	COG1408	metallophosphoesterase
EXW52_RS12350	COG1131	(ABC) transporter
EXW52_RS12360	COG1309	transcriptional regulator
EXW52_RS12370	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS12375	COG0439	Biotin carboxylase
EXW52_RS12380	COG0511	ligase activity, forming carbon-carbon bonds
EXW52_RS12385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW52_RS12390	COG1024	Enoyl-CoA hydratase
EXW52_RS12395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW52_RS12400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW52_RS12445	COG0572	uridine kinase
EXW52_RS12480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW52_RS12510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW52_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS12540	COG1733	regulation of RNA biosynthetic process
EXW52_RS12565	COG1309	transcriptional regulator
EXW52_RS12580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS12595	COG0697	spore germination
EXW52_RS12600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS12625	COG1063	alcohol dehydrogenase
EXW52_RS12635	COG2323	membrane
EXW52_RS12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS12655	COG0697	spore germination
EXW52_RS12675	COG0201	protein transport
EXW52_RS12685	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS12690	COG3227	Zinc metalloprotease (Elastase)
EXW52_RS12695	COG1523	belongs to the glycosyl hydrolase 13 family
EXW52_RS12720	COG1073	alpha beta
EXW52_RS12730	COG0577	efflux transmembrane transporter activity
EXW52_RS12735	COG1136	(ABC) transporter
EXW52_RS12765	COG5002	protein histidine kinase activity
EXW52_RS12770	COG0745	RESPONSE REGULATOR receiver
EXW52_RS12775	COG1011	Hydrolase
EXW52_RS12800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW52_RS12805	COG1183	phosphatidylcholine synthase activity
EXW52_RS12815	COG1132	(ABC) transporter
EXW52_RS12820	COG3961	Belongs to the TPP enzyme family
EXW52_RS12840	COG0322	excinuclease ABC activity
EXW52_RS12865	COG2318	DinB family
EXW52_RS12880	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW52_RS12905	COG3878	Protein conserved in bacteria
EXW52_RS12930	COG1051	belongs to the nudix hydrolase family
EXW52_RS12935	COG0592	DNA-directed DNA polymerase activity
EXW52_RS12940	COG2816	NAD+ diphosphatase activity
EXW52_RS12950	COG2223	nitrite transmembrane transporter activity
EXW52_RS12960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS12990	COG0697	spore germination
EXW52_RS12995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS13010	COG0584	glycerophosphoryl diester phosphodiesterase
EXW52_RS13025	COG1733	regulation of RNA biosynthetic process
EXW52_RS13035	COG2814	Major facilitator Superfamily
EXW52_RS13045	COG1132	(ABC) transporter
EXW52_RS13045	COG2375	cellular response to nickel ion
EXW52_RS13050	COG1132	(ABC) transporter
EXW52_RS13080	COG0768	penicillin binding
EXW52_RS13085	COG0671	phosphoesterase, PA-phosphatase related
EXW52_RS13090	COG0604	alcohol dehydrogenase
EXW52_RS13095	COG5002	protein histidine kinase activity
EXW52_RS13100	COG0745	RESPONSE REGULATOR receiver
EXW52_RS13110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW52_RS13120	COG2205	protein histidine kinase activity
EXW52_RS13135	COG1122	ATPase activity
EXW52_RS13140	COG4720	Psort location CytoplasmicMembrane, score
EXW52_RS13145	COG1794	racemase activity, acting on amino acids and derivatives
EXW52_RS13150	COG1819	glycosyl
EXW52_RS13160	COG0768	penicillin binding
EXW52_RS13165	COG5002	protein histidine kinase activity
EXW52_RS13170	COG0561	phosphatase activity
EXW52_RS13215	COG2124	cytochrome p450
EXW52_RS13260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW52_RS13270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS13275	COG0460	homoserine dehydrogenase
EXW52_RS13295	COG0577	efflux transmembrane transporter activity
EXW52_RS13300	COG1136	(ABC) transporter
EXW52_RS13315	COG0488	(ABC) transporter
EXW52_RS13320	COG0667	Aldo Keto reductase
EXW52_RS13325	COG0583	DNA-binding transcription factor activity
EXW52_RS13340	COG2205	protein histidine kinase activity
EXW52_RS13345	COG0745	RESPONSE REGULATOR receiver
EXW52_RS13355	COG3773	Cell wall hydrolase
EXW52_RS13360	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW52_RS13370	COG3386	PFAM SMP-30 Gluconolaconase
EXW52_RS13415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS13430	COG2959	enzyme of heme biosynthesis
EXW52_RS13455	COG3483	tryptophan 2,3-dioxygenase activity
EXW52_RS13460	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW52_RS13465	COG3844	kynureninase activity
EXW52_RS13470	COG1309	transcriptional regulator
EXW52_RS13485	COG3284	Transcriptional regulator
EXW52_RS13500	COG1349	DNA-binding transcription factor activity
EXW52_RS13520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW52_RS13525	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW52_RS13530	COG0022	dehydrogenase e1 component
EXW52_RS13535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW52_RS13545	COG2223	nitrite transmembrane transporter activity
EXW52_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS13560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW52_RS13560	COG0456	acetyltransferase
EXW52_RS13595	COG4176	ABC-type proline glycine betaine transport system permease component
EXW52_RS13600	COG0517	IMP dehydrogenase activity
EXW52_RS13600	COG4175	Glycine betaine
EXW52_RS13625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW52_RS13630	COG2153	protein acetylation
EXW52_RS13635	COG3397	chitin binding
EXW52_RS13645	COG1819	glycosyl
EXW52_RS13660	COG2205	protein histidine kinase activity
EXW52_RS13665	COG2315	Protein conserved in bacteria
EXW52_RS13710	COG3973	AAA domain
EXW52_RS13725	COG2105	PFAM AIG2 family protein
EXW52_RS13730	COG0514	ATP-dependent DNA helicase (RecQ)
EXW52_RS13755	COG4637	Psort location Cytoplasmic, score
EXW52_RS13775	COG1227	inorganic diphosphatase activity
EXW52_RS13780	COG3397	chitin binding
EXW52_RS13785	COG2318	DinB family
EXW52_RS13800	COG1162	GTPase activity
EXW52_RS13805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW52_RS13810	COG1115	amino acid carrier protein
EXW52_RS13815	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS13820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW52_RS13830	COG3938	Belongs to the proline racemase family
EXW52_RS13835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW52_RS13885	COG1078	dGTPase activity
EXW52_RS13890	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS13905	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW52_RS13910	COG4166	transmembrane transport
EXW52_RS13920	COG4948	Mandelate Racemase Muconate Lactonizing
EXW52_RS13940	COG0667	Aldo Keto reductase
EXW52_RS13990	COG2936	dipeptidyl-peptidase activity
EXW52_RS14000	COG0745	RESPONSE REGULATOR receiver
EXW52_RS14020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW52_RS14025	COG1164	Oligoendopeptidase f
EXW52_RS14045	COG1307	EDD domain protein, DegV family
EXW52_RS14070	COG1335	isochorismatase
EXW52_RS14085	COG2814	Major facilitator Superfamily
EXW52_RS14095	COG1664	Polymer-forming cytoskeletal
EXW52_RS14100	COG0789	Transcriptional regulator
EXW52_RS14105	COG4533	DNA binding
EXW52_RS14110	COG2814	Major facilitator Superfamily
EXW52_RS14110	COG0477	Major facilitator Superfamily
EXW52_RS14125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW52_RS14130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW52_RS14135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS14140	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS14145	COG3328	transposase activity
EXW52_RS14165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS14170	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS14175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS14195	COG2261	transglycosylase associated protein
EXW52_RS14210	COG2226	methyltransferase
EXW52_RS14245	COG0436	Aminotransferase
EXW52_RS14250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW52_RS14280	COG1131	(ABC) transporter
EXW52_RS14285	COG2188	Transcriptional regulator
EXW52_RS14325	COG0628	permease
EXW52_RS14355	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW52_RS14365	COG0697	spore germination
EXW52_RS14390	COG4912	Dna alkylation repair
EXW52_RS14415	COG2814	Major facilitator Superfamily
EXW52_RS14420	COG1368	sulfuric ester hydrolase activity
EXW52_RS14435	COG0488	(ABC) transporter
EXW52_RS14440	COG1033	growth of symbiont in host cell
EXW52_RS14440	COG2409	Drug exporters of the RND superfamily
EXW52_RS14445	COG1309	transcriptional regulator
EXW52_RS14465	COG0287	Prephenate dehydrogenase
EXW52_RS14480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW52_RS14480	COG1605	Chorismate mutase
EXW52_RS14505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW52_RS14520	COG3584	3D domain protein
EXW52_RS14520	COG1388	LysM domain
EXW52_RS14530	COG0346	lactoylglutathione lyase activity
EXW52_RS14540	COG0431	NADPH-dependent FMN reductase
EXW52_RS14545	COG2610	gluconate transmembrane transporter activity
EXW52_RS14550	COG1024	Enoyl-CoA hydratase
EXW52_RS14560	COG3829	transcription factor binding
EXW52_RS14560	COG3290	protein histidine kinase activity
EXW52_RS14570	COG0579	oxidoreductase
EXW52_RS14575	COG1879	ABC-type sugar transport system periplasmic component
EXW52_RS14590	COG1129	ABC transporter
EXW52_RS14595	COG2390	Transcriptional regulator
EXW52_RS14610	COG1830	Aldolase
EXW52_RS14615	COG2226	methyltransferase
EXW52_RS14630	COG0346	lactoylglutathione lyase activity
EXW52_RS14635	COG2329	Antibiotic biosynthesis monooxygenase
EXW52_RS14655	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW52_RS14660	COG2207	Transcriptional regulator
EXW52_RS14665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS14670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW52_RS14675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW52_RS14680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW52_RS14685	COG3239	Fatty acid desaturase
EXW52_RS14705	COG3655	Transcriptional regulator
EXW52_RS14750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS14755	COG0346	lactoylglutathione lyase activity
EXW52_RS14785	COG0714	Associated with various cellular activities
EXW52_RS14805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW52_RS14810	COG0753	catalase activity
EXW52_RS14820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW52_RS14840	COG0778	Nitroreductase
EXW52_RS14845	COG1846	Transcriptional regulator
EXW52_RS14880	COG1725	Transcriptional regulator
EXW52_RS14915	COG2207	Transcriptional regulator
EXW52_RS14920	COG0456	acetyltransferase
EXW52_RS14935	COG0697	spore germination
EXW52_RS14940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS14950	COG1671	Belongs to the UPF0178 family
EXW52_RS14965	COG0642	Histidine kinase
EXW52_RS14970	COG0745	RESPONSE REGULATOR receiver
EXW52_RS14975	COG0596	Alpha beta hydrolase
EXW52_RS14985	COG0456	acetyltransferase
EXW52_RS14985	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW52_RS15010	COG0730	response to heat
EXW52_RS15020	COG0833	amino acid
EXW52_RS15030	COG4335	DNA alkylation repair
EXW52_RS15060	COG0768	penicillin binding
EXW52_RS15070	COG3104	oligopeptide transport
EXW52_RS15075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW52_RS15090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW52_RS15095	COG1984	allophanate hydrolase subunit 2
EXW52_RS15100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW52_RS15105	COG1414	Transcriptional regulator
EXW52_RS15125	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS15150	COG0640	Transcriptional regulator
EXW52_RS15155	COG3314	Sporulation integral membrane protein YlbJ
EXW52_RS15175	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW52_RS15190	COG3848	Pyruvate phosphate dikinase
EXW52_RS15190	COG0574	Belongs to the PEP-utilizing enzyme family
EXW52_RS15200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW52_RS15210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS15225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW52_RS15250	COG1131	(ABC) transporter
EXW52_RS15265	COG1073	alpha beta
EXW52_RS15290	COG5002	protein histidine kinase activity
EXW52_RS15295	COG0745	RESPONSE REGULATOR receiver
EXW52_RS15305	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW52_RS15325	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW52_RS15330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW52_RS15335	COG1121	(ABC) transporter
EXW52_RS15350	COG1999	signal sequence binding
EXW52_RS15355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW52_RS15360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW52_RS15385	COG0798	PFAM Bile acid sodium symporter
EXW52_RS15390	COG0346	lactoylglutathione lyase activity
EXW52_RS15395	COG0640	Transcriptional regulator
EXW52_RS15405	COG3320	Male sterility
EXW52_RS15405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW52_RS15410	COG1309	transcriptional regulator
EXW52_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS15420	COG1522	sequence-specific DNA binding
EXW52_RS15435	COG0346	lactoylglutathione lyase activity
EXW52_RS15460	COG2226	methyltransferase
EXW52_RS15470	COG2814	Major facilitator Superfamily
EXW52_RS15505	COG0745	RESPONSE REGULATOR receiver
EXW52_RS15510	COG3850	Histidine kinase
EXW52_RS15510	COG5002	protein histidine kinase activity
EXW52_RS15540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW52_RS15555	COG2309	aminopeptidase activity
EXW52_RS15565	COG1690	Belongs to the RtcB family
EXW52_RS15580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW52_RS15600	COG1136	(ABC) transporter
EXW52_RS15605	COG0577	efflux transmembrane transporter activity
EXW52_RS15625	COG3850	Histidine kinase
EXW52_RS15625	COG5002	protein histidine kinase activity
EXW52_RS15640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS15670	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW52_RS15690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW52_RS15715	COG5444	nuclease activity
EXW52_RS15760	COG2814	Major facilitator Superfamily
EXW52_RS15810	COG1876	peptidase activity
EXW52_RS15815	COG2843	Capsule synthesis protein
EXW52_RS15830	COG0477	Major facilitator Superfamily
EXW52_RS15845	COG1846	Transcriptional regulator
EXW52_RS15850	COG2814	Major facilitator Superfamily
EXW52_RS15870	COG2211	Major facilitator Superfamily
EXW52_RS15930	COG0789	Transcriptional regulator
EXW52_RS15960	COG1476	TRANSCRIPTIONal
EXW52_RS15975	COG1288	antiporter activity
EXW52_RS15980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW52_RS16025	COG3718	enzyme involved in inositol metabolism
EXW52_RS16055	COG0673	inositol 2-dehydrogenase activity
EXW52_RS16060	COG2814	Major facilitator Superfamily
EXW52_RS16065	COG1609	Transcriptional regulator
EXW52_RS16085	COG1073	alpha beta
EXW52_RS16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS16155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS16200	COG4187	Peptidase family M20/M25/M40
EXW52_RS16220	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW52_RS16225	COG2031	fatty acid transporter
EXW52_RS16235	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW52_RS16300	COG1288	antiporter activity
EXW52_RS16305	COG2356	endonuclease I
EXW52_RS16310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW52_RS16325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW52_RS16345	COG1785	Belongs to the alkaline phosphatase family
EXW52_RS16350	COG0778	Nitroreductase
EXW52_RS16355	COG1733	regulation of RNA biosynthetic process
EXW52_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS16380	COG1131	(ABC) transporter
EXW52_RS16410	COG1595	DNA-templated transcription, initiation
EXW52_RS16425	COG1011	Hydrolase
EXW52_RS16430	COG2365	Tyrosine phosphatase family
EXW52_RS16450	COG0346	lactoylglutathione lyase activity
EXW52_RS16455	COG1940	carbohydrate kinase activity
EXW52_RS16460	COG0738	Major facilitator superfamily
EXW52_RS16465	COG0110	maltose O-acetyltransferase activity
EXW52_RS16480	COG0628	permease
EXW52_RS16485	COG2261	transglycosylase associated protein
EXW52_RS16525	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW52_RS16535	COG1253	flavin adenine dinucleotide binding
EXW52_RS16540	COG0789	Transcriptional regulator
EXW52_RS16545	COG0697	spore germination
EXW52_RS16555	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW52_RS16560	COG3813	Protein conserved in bacteria
EXW52_RS16565	COG2706	6-phosphogluconolactonase activity
EXW52_RS16570	COG1070	Carbohydrate kinase
EXW52_RS16580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW52_RS16585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW52_RS16590	COG4702	Belongs to the UPF0303 family
EXW52_RS16600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS16620	COG0384	phenazine biosynthesis protein PhzF
EXW52_RS16640	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS16645	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW52_RS16650	COG1733	regulation of RNA biosynthetic process
EXW52_RS16670	COG1191	sigma factor activity
EXW52_RS16695	COG1876	peptidase activity
EXW52_RS16720	COG0741	lytic transglycosylase activity
EXW52_RS16780	COG1522	sequence-specific DNA binding
EXW52_RS16785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW52_RS16790	COG0657	acetylesterase activity
EXW52_RS16800	COG2814	Major facilitator Superfamily
EXW52_RS16805	COG1309	transcriptional regulator
EXW52_RS16825	COG2224	Isocitrate lyase
EXW52_RS16855	COG0814	amino acid
EXW52_RS16880	COG1151	hydroxylamine reductase activity
EXW52_RS16910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS16920	COG2072	flavoprotein involved in K transport
EXW52_RS16960	COG0604	alcohol dehydrogenase
EXW52_RS16965	COG1113	amino acid transport
EXW52_RS16975	COG2814	Major facilitator Superfamily
EXW52_RS16985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW52_RS16990	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS17000	COG0534	Mate efflux family protein
EXW52_RS17005	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS17010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW52_RS17025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW52_RS17030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW52_RS17050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS17055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS17060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS17065	COG3739	integral membrane protein
EXW52_RS17085	COG0583	DNA-binding transcription factor activity
EXW52_RS17105	COG1193	negative regulation of DNA recombination
EXW52_RS17125	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW52_RS17130	COG1164	Oligoendopeptidase f
EXW52_RS17155	COG3781	membrane
EXW52_RS17170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW52_RS17225	COG0640	Transcriptional regulator
EXW52_RS17230	COG0604	alcohol dehydrogenase
EXW52_RS17235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW52_RS17240	COG0457	Tetratricopeptide repeat
EXW52_RS17250	COG2808	Putative FMN-binding domain
EXW52_RS17255	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW52_RS17265	COG0277	FAD linked oxidase domain protein
EXW52_RS17285	COG1285	pathogenesis
EXW52_RS17295	COG2514	catechol 2,3-dioxygenase activity
EXW52_RS17300	COG2720	vancomycin resistance protein
EXW52_RS17325	COG1278	Cold shock
EXW52_RS17335	COG0716	FMN binding
EXW52_RS17345	COG0494	nUDIX hydrolase
EXW52_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS17375	COG0165	Argininosuccinate lyase
EXW52_RS17390	COG4145	pantothenate transmembrane transporter activity
EXW52_RS17400	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS17415	COG1657	PFAM Prenyltransferase squalene oxidase
EXW52_RS17420	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW52_RS17425	COG2962	Rard protein
EXW52_RS17430	COG3326	Membrane
EXW52_RS17435	COG0531	amino acid
EXW52_RS17470	COG2226	methyltransferase
EXW52_RS17475	COG4166	transmembrane transport
EXW52_RS17480	COG4166	transmembrane transport
EXW52_RS17485	COG4166	transmembrane transport
EXW52_RS17500	COG1595	DNA-templated transcription, initiation
EXW52_RS17510	COG1131	(ABC) transporter
EXW52_RS17530	COG0673	inositol 2-dehydrogenase activity
EXW52_RS17535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW52_RS17540	COG0187	DNA topoisomerase II activity
EXW52_RS17545	COG1832	CoA-binding protein
EXW52_RS17550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW52_RS17555	COG0745	RESPONSE REGULATOR receiver
EXW52_RS17565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW52_RS17565	COG1328	CTP reductase activity
EXW52_RS17575	COG4841	protein insertion into membrane
EXW52_RS17580	COG0824	Thioesterase
EXW52_RS17600	COG2176	DNA-directed DNA polymerase activity
EXW52_RS17605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS17620	COG1132	(ABC) transporter
EXW52_RS17625	COG1266	CAAX protease self-immunity
EXW52_RS17630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW52_RS17660	COG2211	Major facilitator Superfamily
EXW52_RS17670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW52_RS17685	COG0183	Belongs to the thiolase family
EXW52_RS17690	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS17695	COG1268	BioY protein
EXW52_RS17700	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS17705	COG1396	sequence-specific DNA binding
EXW52_RS17745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS17755	COG5002	protein histidine kinase activity
EXW52_RS17765	COG0400	carboxylic ester hydrolase activity
EXW52_RS17770	COG0346	lactoylglutathione lyase activity
EXW52_RS17775	COG0069	glutamate synthase activity
EXW52_RS17780	COG1902	pentaerythritol trinitrate reductase activity
EXW52_RS17790	COG1329	Transcriptional regulator
EXW52_RS17795	COG0010	Belongs to the arginase family
EXW52_RS17805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW52_RS17810	COG2986	histidine ammonia-lyase
EXW52_RS17820	COG2226	methyltransferase
EXW52_RS17845	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW52_RS17850	COG0785	Cytochrome C biogenesis protein
EXW52_RS17860	COG1473	amidohydrolase
EXW52_RS17865	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW52_RS17870	COG1131	(ABC) transporter
EXW52_RS17880	COG0583	DNA-binding transcription factor activity
EXW52_RS17890	COG1346	cytolysis
EXW52_RS17905	COG0730	response to heat
EXW52_RS17915	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS17915	COG3409	Peptidoglycan-binding domain 1 protein
EXW52_RS17935	COG1132	(ABC) transporter
EXW52_RS17940	COG1132	(ABC) transporter
EXW52_RS17945	COG3763	UPF0154 protein
EXW52_RS17965	COG3639	organic phosphonate transmembrane transporter activity
EXW52_RS17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW52_RS17980	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS17990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW52_RS17995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW52_RS18010	COG1695	Transcriptional regulator
EXW52_RS18015	COG1132	(ABC) transporter
EXW52_RS18050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW52_RS18060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW52_RS18070	COG3420	alginic acid biosynthetic process
EXW52_RS18070	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW52_RS18080	COG1442	glycosyl transferase family 8
EXW52_RS18085	COG1442	glycosyl transferase family 8
EXW52_RS18085	COG1216	Glycosyl transferase, family 2
EXW52_RS18100	COG0297	glycogen (starch) synthase activity
EXW52_RS18110	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS18120	COG1215	transferase activity, transferring glycosyl groups
EXW52_RS18125	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS18130	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS18135	COG1086	Polysaccharide biosynthesis protein
EXW52_RS18140	COG0489	protein tyrosine kinase activity
EXW52_RS18145	COG3944	biosynthesis protein
EXW52_RS18150	COG0174	glutamine synthetase
EXW52_RS18155	COG0789	Transcriptional regulator
EXW52_RS18160	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW52_RS18165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW52_RS18170	COG2860	membrane
EXW52_RS18180	COG0464	growth
EXW52_RS18200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW52_RS18210	COG3584	3D domain protein
EXW52_RS18210	COG1388	LysM domain
EXW52_RS18215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW52_RS18215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW52_RS18215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW52_RS18220	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW52_RS18225	COG1349	DNA-binding transcription factor activity
EXW52_RS18230	COG1979	alcohol dehydrogenase
EXW52_RS18235	COG2322	membrane
EXW52_RS18245	COG1113	amino acid transport
EXW52_RS18255	COG1473	amidohydrolase
EXW52_RS18260	COG1408	metallophosphoesterase
EXW52_RS18265	COG2116	formate transmembrane transporter activity
EXW52_RS18280	COG2217	Heavy metal translocating P-type atpase
EXW52_RS18285	COG2608	mercury ion transmembrane transporter activity
EXW52_RS18290	COG1937	Protein conserved in bacteria
EXW52_RS18310	COG2819	hydrolase of the alpha beta superfamily
EXW52_RS18315	COG1120	ATPase activity
EXW52_RS18320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS18325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS18330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS18335	COG0708	Exodeoxyribonuclease III
EXW52_RS18340	COG2169	Transcriptional regulator
EXW52_RS18345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW52_RS18350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW52_RS18355	COG2706	6-phosphogluconolactonase activity
EXW52_RS18360	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW52_RS18365	COG2364	Membrane
EXW52_RS18375	COG0346	lactoylglutathione lyase activity
EXW52_RS18380	COG3300	MHYT domain
EXW52_RS18380	COG5001	Diguanylate cyclase
EXW52_RS18420	COG1346	cytolysis
EXW52_RS18430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS18435	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW52_RS18435	COG0596	Alpha beta hydrolase
EXW52_RS18440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW52_RS18450	COG2188	Transcriptional regulator
EXW52_RS18455	COG2723	6-phospho-beta-galactosidase activity
EXW52_RS18465	COG3773	Cell wall hydrolase
EXW52_RS18475	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW52_RS18485	COG2723	6-phospho-beta-galactosidase activity
EXW52_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS18490	COG2190	(PTS) system
EXW52_RS18490	COG1263	PTS System
EXW52_RS18495	COG3711	transcriptional antiterminator
EXW52_RS18505	COG0640	Transcriptional regulator
EXW52_RS18510	COG0697	spore germination
EXW52_RS18515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS18520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW52_RS18525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW52_RS18535	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW52_RS18540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW52_RS18545	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW52_RS18550	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW52_RS18550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW52_RS18560	COG2359	stage V sporulation protein S
EXW52_RS18565	COG1692	metallophosphoesterase
EXW52_RS18570	COG1418	mRNA catabolic process
EXW52_RS18575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW52_RS18580	COG1058	Belongs to the CinA family
EXW52_RS18580	COG1546	Belongs to the CinA family
EXW52_RS18585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW52_RS18590	COG1426	Protein conserved in bacteria
EXW52_RS18605	COG0300	oxidoreductase activity
EXW52_RS18610	COG0612	Peptidase, M16
EXW52_RS18615	COG0612	Peptidase, M16
EXW52_RS18620	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW52_RS18625	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW52_RS18630	COG3845	ABC transporter
EXW52_RS18635	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW52_RS18640	COG2188	Transcriptional regulator
EXW52_RS18650	COG1674	ftsk spoiiie
EXW52_RS18660	COG0740	serine-type endopeptidase activity
EXW52_RS18665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW52_RS18675	COG0527	aspartate kinase activity
EXW52_RS18680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW52_RS18685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW52_RS18690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW52_RS18695	COG1873	PFAM PRC-barrel domain
EXW52_RS18700	COG0612	Peptidase, M16
EXW52_RS18705	COG0726	polysaccharide deacetylase
EXW52_RS18710	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW52_RS18720	COG0196	riboflavin kinase activity
EXW52_RS18730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW52_RS18735	COG1550	Protein conserved in bacteria
EXW52_RS18740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW52_RS18745	COG1358	cellular component organization or biogenesis
EXW52_RS18750	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW52_RS18755	COG0195	Participates in both transcription termination and antitermination
EXW52_RS18760	COG0779	Required for maturation of 30S ribosomal subunits
EXW52_RS18770	COG0442	prolyl-tRNA aminoacylation
EXW52_RS18775	COG0750	zinc metalloprotease
EXW52_RS18785	COG4589	Belongs to the CDS family
EXW52_RS18795	COG0233	cytoplasmic translational termination
EXW52_RS18800	COG0528	UMP kinase activity
EXW52_RS18805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW52_RS18810	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW52_RS18815	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW52_RS18820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW52_RS18825	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW52_RS18830	COG4974	Belongs to the 'phage' integrase family
EXW52_RS18835	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW52_RS18840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW52_RS18845	COG0758	DNA mediated transformation
EXW52_RS18850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW52_RS18855	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW52_RS18860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW52_RS18875	COG0335	large ribosomal subunit rRNA binding
EXW52_RS18880	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW52_RS18885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW52_RS18890	COG1837	Belongs to the UPF0109 family
EXW52_RS18900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW52_RS18905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW52_RS18910	COG0552	protein localization to endoplasmic reticulum
EXW52_RS18915	COG1196	nuclear chromosome segregation
EXW52_RS18920	COG0571	ribonuclease III activity
EXW52_RS18925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW52_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS18935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW52_RS18940	COG0416	fatty acid biosynthetic process
EXW52_RS18945	COG2050	protein possibly involved in aromatic compounds catabolism
EXW52_RS18945	COG1349	DNA-binding transcription factor activity
EXW52_RS18950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW52_RS18955	COG1461	Dihydroxyacetone kinase
EXW52_RS18960	COG1302	Protein conserved in bacteria
EXW52_RS18975	COG1564	THIamine pyrophosphokinase
EXW52_RS18980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW52_RS18990	COG0515	serine threonine protein kinase
EXW52_RS18990	COG2815	serine threonine protein kinase
EXW52_RS18995	COG0631	protein serine/threonine phosphatase activity
EXW52_RS19000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW52_RS19005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW52_RS19005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW52_RS19010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW52_RS19015	COG0242	peptide deformylase activity
EXW52_RS19020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW52_RS19025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW52_RS19030	COG1758	RNA polymerase activity
EXW52_RS19045	COG1561	YicC-like family, N-terminal region
EXW52_RS19050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW52_RS19065	COG0006	proline dipeptidase activity
EXW52_RS19085	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW52_RS19105	COG0167	dihydroorotate dehydrogenase activity
EXW52_RS19110	COG0543	2 iron, 2 sulfur cluster binding
EXW52_RS19115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW52_RS19125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW52_RS19130	COG0540	Belongs to the ATCase OTCase family
EXW52_RS19140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW52_RS19145	COG0564	pseudouridine synthase activity
EXW52_RS19150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW52_RS19160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW52_RS19165	COG3599	regulation of cell shape
EXW52_RS19170	COG2302	S4 RNA-binding domain
EXW52_RS19175	COG0762	integral membrane protein
EXW52_RS19180	COG1799	cell septum assembly
EXW52_RS19185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW52_RS19195	COG1873	PFAM PRC-barrel domain
EXW52_RS19200	COG1191	sigma factor activity
EXW52_RS19205	COG1191	sigma factor activity
EXW52_RS19215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW52_RS19220	COG0849	cell division
EXW52_RS19225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW52_RS19240	COG0772	Belongs to the SEDS family
EXW52_RS19245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW52_RS19250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW52_RS19255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW52_RS19260	COG0768	penicillin binding
EXW52_RS19265	COG0768	penicillin binding
EXW52_RS19275	COG0275	rRNA processing
EXW52_RS19280	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW52_RS19285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW52_RS19290	COG0454	-acetyltransferase
EXW52_RS19300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW52_RS19305	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW52_RS19310	COG1323	Belongs to the UPF0348 family
EXW52_RS19315	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW52_RS19320	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW52_RS19325	COG3314	Sporulation integral membrane protein YlbJ
EXW52_RS19335	COG0742	ribosomal rna small subunit methyltransferase
EXW52_RS19345	COG4471	UPF0298 protein
EXW52_RS19350	COG3679	Belongs to the UPF0342 family
EXW52_RS19355	COG0406	alpha-ribazole phosphatase activity
EXW52_RS19370	COG2340	Cysteine-rich secretory protein family
EXW52_RS19380	COG3336	cytochrome c oxidase
EXW52_RS19405	COG0109	protoheme IX farnesyltransferase activity
EXW52_RS19410	COG1612	heme a metabolic process
EXW52_RS19415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW52_RS19420	COG0772	Belongs to the SEDS family
EXW52_RS19425	COG4838	Belongs to the UPF0358 family
EXW52_RS19430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW52_RS19435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW52_RS19445	COG4896	Protein conserved in bacteria
EXW52_RS19460	COG1217	gtp-binding protein TYPA
EXW52_RS19470	COG0483	inositol monophosphate 1-phosphatase activity
EXW52_RS19480	COG4493	Belongs to the UPF0637 family
EXW52_RS19485	COG4476	Belongs to the UPF0223 family
EXW52_RS19490	COG1982	Orn Lys Arg decarboxylase major
EXW52_RS19535	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW52_RS19540	COG0022	dehydrogenase e1 component
EXW52_RS19545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW52_RS19560	COG0561	phosphatase activity
EXW52_RS19565	COG5503	Protein of unknown function (DUF1447)
EXW52_RS19570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW52_RS19575	COG0569	domain protein
EXW52_RS19585	COG1473	amidohydrolase
EXW52_RS19590	COG2171	N-acyltransferase activity
EXW52_RS19595	COG0583	DNA-binding transcription factor activity
EXW52_RS19600	COG0517	IMP dehydrogenase activity
EXW52_RS19610	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW52_RS19620	COG4703	Protein of unknown function (DUF1797)
EXW52_RS19635	COG2200	EAL domain
EXW52_RS19640	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS19645	COG1408	metallophosphoesterase
EXW52_RS19690	COG2814	Major facilitator Superfamily
EXW52_RS19700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW52_RS19710	COG3209	COG3209 Rhs family protein
EXW52_RS19720	COG2205	protein histidine kinase activity
EXW52_RS19730	COG0436	Aminotransferase
EXW52_RS19735	COG1609	Transcriptional regulator
EXW52_RS19740	COG3833	ABC-type maltose transport systems, permease component
EXW52_RS19745	COG1175	transmembrane transport
EXW52_RS19750	COG2182	Extracellular solute-binding protein
EXW52_RS19760	COG0366	Alpha amylase catalytic
EXW52_RS19765	COG3842	ATPase activity
EXW52_RS19805	COG0183	Belongs to the thiolase family
EXW52_RS19835	COG1695	Transcriptional regulator
EXW52_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS19850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW52_RS19855	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW52_RS19860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW52_RS19865	COG0436	Aminotransferase
EXW52_RS19870	COG1850	ribulose-bisphosphate carboxylase activity
EXW52_RS19875	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW52_RS19880	COG0235	Class ii aldolase
EXW52_RS19885	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW52_RS19900	COG2084	Dehydrogenase
EXW52_RS19910	COG2199	diguanylate cyclase activity
EXW52_RS19915	COG0778	Nitroreductase
EXW52_RS19940	COG1263	PTS System
EXW52_RS19940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW52_RS19940	COG2190	(PTS) system
EXW52_RS19945	COG3711	transcriptional antiterminator
EXW52_RS19955	COG2188	Transcriptional regulator
EXW52_RS19960	COG0363	glucosamine-6-phosphate deaminase activity
EXW52_RS19965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW52_RS19975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW52_RS19980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW52_RS19990	COG1547	Domain of unknown function (DUF309)
EXW52_RS20000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW52_RS20005	COG4086	secreted protein
EXW52_RS20010	COG0561	phosphatase activity
EXW52_RS20015	COG0697	spore germination
EXW52_RS20030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW52_RS20070	COG1686	Belongs to the peptidase S11 family
EXW52_RS20075	COG1725	Transcriptional regulator
EXW52_RS20080	COG1131	(ABC) transporter
EXW52_RS20100	COG1846	Transcriptional regulator
EXW52_RS20115	COG0598	Magnesium transport protein CorA
EXW52_RS20130	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW52_RS20140	COG4974	Belongs to the 'phage' integrase family
EXW52_RS20150	COG0735	belongs to the Fur family
EXW52_RS20155	COG1300	Membrane
EXW52_RS20175	COG0667	Aldo Keto reductase
EXW52_RS20180	COG0656	L-ascorbic acid biosynthetic process
EXW52_RS20185	COG0456	acetyltransferase
EXW52_RS20185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW52_RS20195	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS20195	COG1525	nuclease
EXW52_RS20195	COG4085	toxin activity
EXW52_RS20200	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW52_RS20210	COG0596	Alpha beta hydrolase
EXW52_RS20215	COG2056	Na+-H+ antiporter family
EXW52_RS20220	COG1609	Transcriptional regulator
EXW52_RS20225	COG0456	acetyltransferase
EXW52_RS20230	COG1073	alpha beta
EXW52_RS20245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW52_RS20245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW52_RS20250	COG0307	riboflavin synthase, alpha
EXW52_RS20255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW52_RS20255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW52_RS20270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW52_RS20275	COG4106	trans-aconitate 2-methyltransferase activity
EXW52_RS20280	COG2226	methyltransferase
EXW52_RS20280	COG1073	alpha beta
EXW52_RS20285	COG0156	8-amino-7-oxononanoate synthase activity
EXW52_RS20295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW52_RS20305	COG1757	Na H antiporter
EXW52_RS20310	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS20320	COG1522	sequence-specific DNA binding
EXW52_RS20355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW52_RS20365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW52_RS20375	COG0300	oxidoreductase activity
EXW52_RS20380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS20385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW52_RS20390	COG1760	l-serine dehydratase
EXW52_RS20395	COG1760	l-serine dehydratase
EXW52_RS20405	COG1234	tRNA 3'-trailer cleavage
EXW52_RS20435	COG1131	(ABC) transporter
EXW52_RS20450	COG1285	pathogenesis
EXW52_RS20465	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW52_RS20470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS20485	COG1376	ErfK ybiS ycfS ynhG family protein
EXW52_RS20490	COG4129	membrane
EXW52_RS20495	COG1126	abc transporter atp-binding protein
EXW52_RS20500	COG0765	amino acid transport
EXW52_RS20505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW52_RS20515	COG2816	NAD+ diphosphatase activity
EXW52_RS20520	COG2323	membrane
EXW52_RS20525	COG0772	Belongs to the SEDS family
EXW52_RS20530	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW52_RS20535	COG0022	dehydrogenase e1 component
EXW52_RS20540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW52_RS20545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW52_RS20550	COG3426	butyrate kinase activity
EXW52_RS20560	COG0280	phosphate acetyltransferase
EXW52_RS20565	COG3829	transcription factor binding
EXW52_RS20565	COG3290	protein histidine kinase activity
EXW52_RS20575	COG0584	glycerophosphoryl diester phosphodiesterase
EXW52_RS20580	COG3093	addiction module antidote protein HigA
EXW52_RS20615	COG0745	RESPONSE REGULATOR receiver
EXW52_RS20620	COG0750	zinc metalloprotease
EXW52_RS20625	COG0497	DNA recombination
EXW52_RS20630	COG1438	arginine binding
EXW52_RS20635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW52_RS20640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW52_RS20645	COG0142	geranyltranstransferase activity
EXW52_RS20650	COG1722	exodeoxyribonuclease VII activity
EXW52_RS20655	COG1570	exodeoxyribonuclease VII activity
EXW52_RS20660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW52_RS20665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW52_RS20670	COG1302	Protein conserved in bacteria
EXW52_RS20675	COG0439	Biotin carboxylase
EXW52_RS20680	COG0511	ligase activity, forming carbon-carbon bonds
EXW52_RS20725	COG3854	ATPases associated with a variety of cellular activities
EXW52_RS20745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW52_RS20750	COG0006	proline dipeptidase activity
EXW52_RS20755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW52_RS20765	COG3872	metal-dependent enzyme
EXW52_RS20775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW52_RS20780	COG1321	iron dependent repressor
EXW52_RS20810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS20820	COG1609	Transcriptional regulator
EXW52_RS20830	COG2076	Multidrug Resistance protein
EXW52_RS20835	COG2076	Multidrug Resistance protein
EXW52_RS20875	COG1725	Transcriptional regulator
EXW52_RS20890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW52_RS20895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW52_RS20900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW52_RS20905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW52_RS20930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW52_RS20955	COG4970	Tfp pilus assembly protein FimT
EXW52_RS20965	COG1459	type II secretion system
EXW52_RS20970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW52_RS21025	COG0646	methionine synthase
EXW52_RS21025	COG1410	methionine synthase
EXW52_RS21030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW52_RS21030	COG0646	methionine synthase
EXW52_RS21035	COG0626	cystathionine gamma-synthase activity
EXW52_RS21040	COG0626	cystathionine gamma-synthase activity
EXW52_RS21055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS21065	COG1940	carbohydrate kinase activity
EXW52_RS21070	COG4483	Protein conserved in bacteria
EXW52_RS21075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW52_RS21080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW52_RS21085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW52_RS21090	COG0704	Plays a role in the regulation of phosphate uptake
EXW52_RS21100	COG0581	inorganic phosphate transmembrane transporter activity
EXW52_RS21105	COG0573	inorganic phosphate transmembrane transporter activity
EXW52_RS21110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW52_RS21115	COG0768	penicillin binding
EXW52_RS21120	COG0477	Major facilitator Superfamily
EXW52_RS21125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW52_RS21145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW52_RS21150	COG0735	belongs to the Fur family
EXW52_RS21155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW52_RS21160	COG1121	(ABC) transporter
EXW52_RS21165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS21175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW52_RS21190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW52_RS21195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW52_RS21200	COG2384	SAM-dependent methyltransferase
EXW52_RS21210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW52_RS21215	COG0358	DNA primase activity
EXW52_RS21225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW52_RS21230	COG0517	IMP dehydrogenase activity
EXW52_RS21235	COG1381	Involved in DNA repair and RecF pathway recombination
EXW52_RS21245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW52_RS21250	COG0295	cytidine deaminase activity
EXW52_RS21255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW52_RS21260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW52_RS21265	COG1480	7TM receptor with intracellular HD hydrolase
EXW52_RS21270	COG1702	phosphate starvation-inducible protein PhoH
EXW52_RS21285	COG1610	YqeY-like protein
EXW52_RS21290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW52_RS21295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW52_RS21300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW52_RS21310	COG0484	heat shock protein binding
EXW52_RS21315	COG0443	Heat shock 70 kDa protein
EXW52_RS21325	COG1420	regulation of RNA biosynthetic process
EXW52_RS21330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW52_RS21335	COG1733	regulation of RNA biosynthetic process
EXW52_RS21340	COG0481	GTPase activity
EXW52_RS21350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW52_RS21355	COG0268	Binds directly to 16S ribosomal RNA
EXW52_RS21360	COG1466	dna polymerase III delta subunit
EXW52_RS21370	COG0658	competence protein
EXW52_RS21370	COG2333	competence protein COMEC
EXW52_RS21375	COG2131	deaminase
EXW52_RS21380	COG1555	photosystem II stabilization
EXW52_RS21380	COG1596	polysaccharide export
EXW52_RS21385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW52_RS21390	COG2226	methyltransferase
EXW52_RS21395	COG0799	negative regulation of ribosome biogenesis
EXW52_RS21400	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW52_RS21405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW52_RS21410	COG1534	Rna-binding protein
EXW52_RS21415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW52_RS21420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW52_RS21425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW52_RS21435	COG0688	phosphatidylethanolamine metabolic process
EXW52_RS21445	COG1595	DNA-templated transcription, initiation
EXW52_RS21450	COG2357	RelA SpoT domain protein
EXW52_RS21460	COG1785	Belongs to the alkaline phosphatase family
EXW52_RS21470	COG2267	carboxylic ester hydrolase activity
EXW52_RS21505	COG1404	Belongs to the peptidase S8 family
EXW52_RS21510	COG3186	Phenylalanine-4-hydroxylase
EXW52_RS21515	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW52_RS21520	COG2514	catechol 2,3-dioxygenase activity
EXW52_RS21525	COG2259	Doxx family
EXW52_RS21565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS21575	COG1012	belongs to the aldehyde dehydrogenase family
EXW52_RS21575	COG1454	alcohol dehydrogenase
EXW52_RS21580	COG0626	cystathionine gamma-synthase activity
EXW52_RS21585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW52_RS21590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW52_RS21595	COG2226	methyltransferase
EXW52_RS21610	COG0768	penicillin binding
EXW52_RS21615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW52_RS21620	COG0572	uridine kinase
EXW52_RS21625	COG0826	peptidase U32
EXW52_RS21630	COG0826	peptidase U32
EXW52_RS21635	COG4122	O-methyltransferase activity
EXW52_RS21640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW52_RS21650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW52_RS21655	COG4472	Bacterial protein of unknown function (DUF965)
EXW52_RS21660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW52_RS21670	COG0628	permease
EXW52_RS21690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW52_RS21700	COG0482	sulfurtransferase activity
EXW52_RS21705	COG1104	cysteine desulfurase activity
EXW52_RS21710	COG1959	2 iron, 2 sulfur cluster binding
EXW52_RS21715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW52_RS21725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW52_RS21730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW52_RS21745	COG1490	D-aminoacyl-tRNA deacylase activity
EXW52_RS21750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW52_RS21755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW52_RS21760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW52_RS21760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW52_RS21765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW52_RS21770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW52_RS21770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW52_RS21780	COG2244	polysaccharide biosynthetic process
EXW52_RS21785	COG2323	membrane
EXW52_RS21795	COG1862	Preprotein translocase
EXW52_RS21800	COG0343	queuine tRNA-ribosyltransferase activity
EXW52_RS21805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW52_RS21815	COG2255	four-way junction helicase activity
EXW52_RS21820	COG0632	four-way junction helicase activity
EXW52_RS21825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW52_RS21855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW52_RS21860	COG0157	Belongs to the NadC ModD family
EXW52_RS21865	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW52_RS21870	COG1104	cysteine desulfurase activity
EXW52_RS21875	COG1827	regulation of RNA biosynthetic process
EXW52_RS21880	COG2258	MOSC domain
EXW52_RS21885	COG0077	Prephenate dehydratase
EXW52_RS21890	COG0577	efflux transmembrane transporter activity
EXW52_RS21895	COG0577	efflux transmembrane transporter activity
EXW52_RS21900	COG1136	(ABC) transporter
EXW52_RS21905	COG5002	protein histidine kinase activity
EXW52_RS21910	COG0745	RESPONSE REGULATOR receiver
EXW52_RS21915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW52_RS21920	COG3290	protein histidine kinase activity
EXW52_RS21930	COG2868	ribosomal protein
EXW52_RS21940	COG1530	ribonuclease E activity
EXW52_RS21945	COG1994	Peptidase M50
EXW52_RS21950	COG0739	heme binding
EXW52_RS21955	COG2894	cell division
EXW52_RS21960	COG0850	regulation of cytokinetic process
EXW52_RS21975	COG1077	Cell shape determining protein MreB Mrl
EXW52_RS21980	COG2003	Belongs to the UPF0758 family
EXW52_RS21985	COG0424	maF-like protein
EXW52_RS21995	COG0285	dihydrofolate synthase activity
EXW52_RS22010	COG1388	LysM domain
EXW52_RS22015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW52_RS22020	COG0113	porphobilinogen synthase activity
EXW52_RS22025	COG1587	Uroporphyrinogen-III synthase
EXW52_RS22030	COG0181	hydroxymethylbilane synthase activity
EXW52_RS22035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW52_RS22040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW52_RS22045	COG1846	Transcriptional regulator
EXW52_RS22050	COG1764	response to oxidative stress
EXW52_RS22055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW52_RS22065	COG1067	ATP-dependent peptidase activity
EXW52_RS22065	COG0470	DNA polymerase III
EXW52_RS22075	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW52_RS22105	COG0622	Phosphoesterase
EXW52_RS22115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW52_RS22120	COG5401	PFAM Sporulation and spore germination
EXW52_RS22130	COG0477	Major facilitator Superfamily
EXW52_RS22140	COG1309	transcriptional regulator
EXW52_RS22150	COG2197	response regulator
EXW52_RS22155	COG2233	PERMEase
EXW52_RS22160	COG0402	S-adenosylhomocysteine deaminase activity
EXW52_RS22165	COG1983	PspC domain protein
EXW52_RS22170	COG1396	sequence-specific DNA binding
EXW52_RS22175	COG0697	spore germination
EXW52_RS22185	COG1959	2 iron, 2 sulfur cluster binding
EXW52_RS22190	COG1668	transmembrane transport
EXW52_RS22195	COG4152	abc transporter atp-binding protein
EXW52_RS22200	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW52_RS22205	COG1360	Flagellar Motor Protein
EXW52_RS22210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW52_RS22215	COG1876	peptidase activity
EXW52_RS22220	COG0824	Thioesterase
EXW52_RS22225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW52_RS22230	COG1053	succinate dehydrogenase
EXW52_RS22235	COG2009	succinate dehydrogenase
EXW52_RS22240	COG1719	4-vinyl reductase, 4VR
EXW52_RS22245	COG0322	excinuclease ABC activity
EXW52_RS22250	COG3118	belongs to the thioredoxin family
EXW52_RS22255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW52_RS22260	COG2086	electron transfer activity
EXW52_RS22265	COG1024	Enoyl-CoA hydratase
EXW52_RS22270	COG1309	transcriptional regulator
EXW52_RS22275	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS22300	COG2318	DinB family
EXW52_RS22330	COG1131	(ABC) transporter
EXW52_RS22335	COG2205	protein histidine kinase activity
EXW52_RS22340	COG0745	RESPONSE REGULATOR receiver
EXW52_RS22350	COG4895	conserved protein (DUF2196)
EXW52_RS22355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW52_RS22365	COG2329	Antibiotic biosynthesis monooxygenase
EXW52_RS22370	COG4509	Sortase family
EXW52_RS22375	COG1120	ATPase activity
EXW52_RS22390	COG5386	Cell surface protein
EXW52_RS22400	COG5386	Cell surface protein
EXW52_RS22405	COG1114	Component of the transport system for branched-chain amino acids
EXW52_RS22415	COG1193	negative regulation of DNA recombination
EXW52_RS22420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW52_RS22420	COG1796	DNA polymerase
EXW52_RS22425	COG1286	toxin biosynthetic process
EXW52_RS22430	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW52_RS22435	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW52_RS22465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW52_RS22470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW52_RS22480	COG1418	mRNA catabolic process
EXW52_RS22505	COG2814	Major facilitator Superfamily
EXW52_RS22510	COG1566	PFAM secretion protein HlyD family protein
EXW52_RS22515	COG1309	transcriptional regulator
EXW52_RS22520	COG1363	Peptidase, m42
EXW52_RS22530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW52_RS22545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW52_RS22555	COG1484	DNA-dependent DNA replication
EXW52_RS22560	COG3611	Membrane attachment protein
EXW52_RS22565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW52_RS22570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW52_RS22575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW52_RS22580	COG0237	dephospho-CoA kinase activity
EXW52_RS22585	COG1971	Probably functions as a manganese efflux pump
EXW52_RS22595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW52_RS22595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW52_RS22600	COG5002	protein histidine kinase activity
EXW52_RS22605	COG0745	RESPONSE REGULATOR receiver
EXW52_RS22620	COG0039	L-malate dehydrogenase activity
EXW52_RS22625	COG0538	isocitrate dehydrogenase activity
EXW52_RS22630	COG0372	Belongs to the citrate synthase family
EXW52_RS22640	COG0628	permease
EXW52_RS22645	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW52_RS22655	COG0205	6-phosphofructokinase activity
EXW52_RS22665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW52_RS22670	COG1725	Transcriptional regulator
EXW52_RS22675	COG0281	malic enzyme
EXW52_RS22680	COG0587	DNA-directed DNA polymerase activity
EXW52_RS22695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW52_RS22710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS22720	COG4109	DRTGG domain
EXW52_RS22730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW52_RS22735	COG0006	proline dipeptidase activity
EXW52_RS22780	COG0662	Cupin 2, conserved barrel domain protein
EXW52_RS22790	COG1476	TRANSCRIPTIONal
EXW52_RS22805	COG1028	Short-chain dehydrogenase reductase Sdr
EXW52_RS22810	COG0589	response to stress
EXW52_RS22825	COG0165	Argininosuccinate lyase
EXW52_RS22830	COG0137	argininosuccinate synthase activity
EXW52_RS22845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS22865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW52_RS22870	COG0827	DNA restriction-modification system
EXW52_RS22875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW52_RS22880	COG3874	Sporulation protein YtfJ
EXW52_RS22895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW52_RS22905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW52_RS22920	COG1104	cysteine desulfurase activity
EXW52_RS22925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW52_RS22935	COG1309	transcriptional regulator
EXW52_RS22940	COG1956	GAF domain-containing protein
EXW52_RS22945	COG0626	cystathionine gamma-synthase activity
EXW52_RS22955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW52_RS22980	COG1595	DNA-templated transcription, initiation
EXW52_RS22990	COG0110	maltose O-acetyltransferase activity
EXW52_RS22995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW52_RS23000	COG0454	-acetyltransferase
EXW52_RS23005	COG0517	IMP dehydrogenase activity
EXW52_RS23010	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW52_RS23030	COG0745	RESPONSE REGULATOR receiver
EXW52_RS23035	COG5002	protein histidine kinase activity
EXW52_RS23040	COG0666	response to abiotic stimulus
EXW52_RS23050	COG1970	mechanosensitive ion channel activity
EXW52_RS23070	COG1609	Transcriptional regulator
EXW52_RS23085	COG4851	CamS sex pheromone cAM373 precursor
EXW52_RS23090	COG3118	belongs to the thioredoxin family
EXW52_RS23100	COG2309	aminopeptidase activity
EXW52_RS23120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS23125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW52_RS23135	COG1674	ftsk spoiiie
EXW52_RS23150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW52_RS23155	COG4848	Belongs to the UPF0354 family
EXW52_RS23160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS23165	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW52_RS23170	COG1363	Peptidase, m42
EXW52_RS23180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS23185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW52_RS23195	COG0510	thiamine kinase activity
EXW52_RS23200	COG1523	belongs to the glycosyl hydrolase 13 family
EXW52_RS23210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW52_RS23215	COG1349	DNA-binding transcription factor activity
EXW52_RS23220	COG1187	pseudouridine synthase activity
EXW52_RS23225	COG2244	polysaccharide biosynthetic process
EXW52_RS23230	COG2081	HI0933 family
EXW52_RS23235	COG2814	Major facilitator Superfamily
EXW52_RS23245	COG3832	glyoxalase III activity
EXW52_RS23265	COG1329	Transcriptional regulator
EXW52_RS23290	COG0314	molybdopterin synthase activity
EXW52_RS23295	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW52_RS23300	COG0303	'Molybdopterin
EXW52_RS23305	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW52_RS23310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW52_RS23315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW52_RS23335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS23345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW52_RS23385	COG0495	leucyl-tRNA aminoacylation
EXW52_RS23390	COG2814	Major facilitator Superfamily
EXW52_RS23395	COG0475	glutathione-regulated potassium exporter activity
EXW52_RS23400	COG0490	domain, Protein
EXW52_RS23405	COG0582	viral genome integration into host DNA
EXW52_RS23415	COG1136	(ABC) transporter
EXW52_RS23430	COG1242	4 iron, 4 sulfur cluster binding
EXW52_RS23435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW52_RS23450	COG2267	carboxylic ester hydrolase activity
EXW52_RS23455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW52_RS23460	COG0671	phosphoesterase, PA-phosphatase related
EXW52_RS23465	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS23480	COG0746	molybdenum cofactor guanylyltransferase activity
EXW52_RS23500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW52_RS23505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW52_RS23550	COG5002	protein histidine kinase activity
EXW52_RS23555	COG3852	Histidine kinase
EXW52_RS23560	COG0753	catalase activity
EXW52_RS23565	COG2267	carboxylic ester hydrolase activity
EXW52_RS23575	COG1368	sulfuric ester hydrolase activity
EXW52_RS23585	COG4895	conserved protein (DUF2196)
EXW52_RS23600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW52_RS23605	COG1116	anion transmembrane transporter activity
EXW52_RS23610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW52_RS23630	COG0494	nUDIX hydrolase
EXW52_RS23665	COG2076	Multidrug Resistance protein
EXW52_RS23675	COG0789	Transcriptional regulator
EXW52_RS23680	COG1854	S-ribosylhomocysteine lyase activity
EXW52_RS23690	COG0288	reversible hydration of carbon dioxide
EXW52_RS23695	COG1271	oxidase subunit
EXW52_RS23700	COG1294	oxidase, subunit
EXW52_RS23725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS23745	COG1842	Phage shock protein A
EXW52_RS23770	COG3859	Proton-coupled thiamine transporter YuaJ
EXW52_RS23775	COG5002	protein histidine kinase activity
EXW52_RS23780	COG0745	RESPONSE REGULATOR receiver
EXW52_RS23805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW52_RS23810	COG1597	lipid kinase activity
EXW52_RS23845	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS23860	COG0577	efflux transmembrane transporter activity
EXW52_RS23865	COG1136	(ABC) transporter
EXW52_RS23870	COG2207	Transcriptional regulator
EXW52_RS23870	COG3708	Transcriptional regulator
EXW52_RS23880	COG1131	(ABC) transporter
EXW52_RS23885	COG5658	integral membrane protein
EXW52_RS23890	COG0640	Transcriptional regulator
EXW52_RS23895	COG0745	RESPONSE REGULATOR receiver
EXW52_RS23900	COG2205	protein histidine kinase activity
EXW52_RS23905	COG0577	efflux transmembrane transporter activity
EXW52_RS23910	COG0577	efflux transmembrane transporter activity
EXW52_RS23915	COG1136	(ABC) transporter
EXW52_RS23920	COG0577	efflux transmembrane transporter activity
EXW52_RS23935	COG2188	Transcriptional regulator
EXW52_RS23955	COG3964	amidohydrolase
EXW52_RS23975	COG4948	Mandelate Racemase Muconate Lactonizing
EXW52_RS23980	COG0318	PFAM AMP-dependent synthetase and ligase
EXW52_RS23990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW52_RS24000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW52_RS24005	COG1169	isochorismate synthase
EXW52_RS24010	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW52_RS24015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW52_RS24020	COG1278	Cold shock
EXW52_RS24030	COG0789	Transcriptional regulator
EXW52_RS24040	COG0058	SHG alpha-glucan phosphorylase activity
EXW52_RS24050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW52_RS24055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW52_RS24060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW52_RS24205	COG1285	pathogenesis
EXW52_RS24210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW52_RS24220	COG0166	Belongs to the GPI family
EXW52_RS24225	COG2155	Conserved Protein
EXW52_RS24230	COG1098	S1 RNA binding domain
EXW52_RS24235	COG0436	Aminotransferase
EXW52_RS24240	COG1522	sequence-specific DNA binding
EXW52_RS24245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW52_RS24250	COG2267	carboxylic ester hydrolase activity
EXW52_RS24260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW52_RS24280	COG5018	Exonuclease
EXW52_RS24285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW52_RS24305	COG2050	protein possibly involved in aromatic compounds catabolism
EXW52_RS24315	COG1268	BioY protein
EXW52_RS24320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW52_RS24325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW52_RS24335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW52_RS24340	COG3584	3D domain protein
EXW52_RS24355	COG1252	NADH dehydrogenase
EXW52_RS24360	COG0492	ferredoxin-NADP+ reductase activity
EXW52_RS24365	COG3708	Transcriptional regulator
EXW52_RS24380	COG1683	Conserved Protein
EXW52_RS24400	COG0316	Belongs to the HesB IscA family
EXW52_RS24405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW52_RS24410	COG4844	belongs to the
EXW52_RS24415	COG1252	NADH dehydrogenase
EXW52_RS24425	COG0390	transport system, permease component
EXW52_RS24430	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW52_RS24455	COG4837	Protein of unknown function (DUF1462)
EXW52_RS24460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW52_RS24470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS24475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW52_RS24490	COG0577	efflux transmembrane transporter activity
EXW52_RS24490	COG1136	(ABC) transporter
EXW52_RS24495	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW52_RS24505	COG0647	UMP catabolic process
EXW52_RS24515	COG2445	Protein of unknown function DUF86
EXW52_RS24520	COG1494	fructose-1,6-bisphosphatase
EXW52_RS24540	COG4470	Protein conserved in bacteria
EXW52_RS24550	COG0789	Transcriptional regulator
EXW52_RS24555	COG4377	Putative membrane peptidase family (DUF2324)
EXW52_RS24575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW52_RS24580	COG0739	heme binding
EXW52_RS24590	COG3377	Domain of unknown function (DUF1805)
EXW52_RS24595	COG0737	Belongs to the 5'-nucleotidase family
EXW52_RS24600	COG1695	Transcriptional regulator
EXW52_RS24610	COG0719	Fe-S assembly protein
EXW52_RS24615	COG0822	iron-sulfur transferase activity
EXW52_RS24620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW52_RS24625	COG0719	Fe-S assembly protein
EXW52_RS24630	COG0396	ATPase activity
EXW52_RS24635	COG1464	Belongs to the NlpA lipoprotein family
EXW52_RS24640	COG1464	Belongs to the NlpA lipoprotein family
EXW52_RS24645	COG2011	ABC-type metal ion transport system permease component
EXW52_RS24660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW52_RS24665	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW52_RS24670	COG0509	glycine decarboxylation via glycine cleavage system
EXW52_RS24675	COG1393	Belongs to the ArsC family
EXW52_RS24710	COG1309	transcriptional regulator
EXW52_RS24715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS24720	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS24725	COG0183	Belongs to the thiolase family
EXW52_RS24730	COG1024	Enoyl-CoA hydratase
EXW52_RS24730	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW52_RS24740	COG1686	Belongs to the peptidase S11 family
EXW52_RS24745	COG0506	proline dehydrogenase activity
EXW52_RS24755	COG0011	TIGRFAM Protein of
EXW52_RS24760	COG0840	transmembrane signaling receptor activity
EXW52_RS24775	COG2814	Major facilitator Superfamily
EXW52_RS24780	COG0531	amino acid
EXW52_RS24805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW52_RS24835	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS24845	COG1376	ErfK ybiS ycfS ynhG family protein
EXW52_RS24850	COG0745	RESPONSE REGULATOR receiver
EXW52_RS24855	COG5002	protein histidine kinase activity
EXW52_RS24865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW52_RS24875	COG0840	transmembrane signaling receptor activity
EXW52_RS24885	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW52_RS24890	COG3227	Zinc metalloprotease (Elastase)
EXW52_RS24895	COG1741	Belongs to the pirin family
EXW52_RS24910	COG0586	Pfam SNARE associated Golgi protein
EXW52_RS24915	COG0475	glutathione-regulated potassium exporter activity
EXW52_RS24920	COG0490	domain, Protein
EXW52_RS24925	COG1115	amino acid carrier protein
EXW52_RS24930	COG0783	Belongs to the Dps family
EXW52_RS24940	COG2318	DinB family
EXW52_RS24945	COG1611	Belongs to the LOG family
EXW52_RS24955	COG1528	Iron-storage protein
EXW52_RS24960	COG2311	Membrane
EXW52_RS24965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS24970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS24975	COG1115	amino acid carrier protein
EXW52_RS24980	COG2910	NAD(P)H-binding
EXW52_RS24995	COG0656	L-ascorbic acid biosynthetic process
EXW52_RS25000	COG2814	Major facilitator Superfamily
EXW52_RS25005	COG1733	regulation of RNA biosynthetic process
EXW52_RS25015	COG1252	NADH dehydrogenase
EXW52_RS25035	COG0840	transmembrane signaling receptor activity
EXW52_RS25035	COG3290	protein histidine kinase activity
EXW52_RS25045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW52_RS25060	COG3655	Transcriptional regulator
EXW52_RS25075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW52_RS25085	COG1733	regulation of RNA biosynthetic process
EXW52_RS25090	COG0778	Nitroreductase
EXW52_RS25095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW52_RS25100	COG4224	UPF0291 protein
EXW52_RS25105	COG1522	sequence-specific DNA binding
EXW52_RS25110	COG0288	reversible hydration of carbon dioxide
EXW52_RS25115	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW52_RS25120	COG2233	PERMEase
EXW52_RS25145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS25165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW52_RS25170	COG0557	exoribonuclease II activity
EXW52_RS25175	COG1647	Serine aminopeptidase, S33
EXW52_RS25180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW52_RS25185	COG1346	cytolysis
EXW52_RS25200	COG0148	phosphopyruvate hydratase activity
EXW52_RS25210	COG0149	triose-phosphate isomerase activity
EXW52_RS25215	COG0126	phosphoglycerate kinase activity
EXW52_RS25220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW52_RS25235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW52_RS25260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW52_RS25275	COG2323	membrane
EXW52_RS25285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW52_RS25290	COG1481	regulation of sporulation
EXW52_RS25295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW52_RS25300	COG1660	Displays ATPase and GTPase activities
EXW52_RS25305	COG1051	belongs to the nudix hydrolase family
EXW52_RS25315	COG0492	ferredoxin-NADP+ reductase activity
EXW52_RS25320	COG0457	Tetratricopeptide repeat
EXW52_RS25325	COG0110	maltose O-acetyltransferase activity
EXW52_RS25330	COG0546	phosphoglycolate phosphatase activity
EXW52_RS25335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW52_RS25340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW52_RS25345	COG1950	PFAM Membrane protein of
EXW52_RS25355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW52_RS25375	COG0789	Transcriptional regulator
EXW52_RS25410	COG0583	DNA-binding transcription factor activity
EXW52_RS25415	COG0789	Transcriptional regulator
EXW52_RS25420	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW52_RS25425	COG0488	(ABC) transporter
EXW52_RS25435	COG1132	(ABC) transporter
EXW52_RS25440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW52_RS25445	COG3409	Peptidoglycan-binding domain 1 protein
EXW52_RS25445	COG0793	Belongs to the peptidase S41A family
EXW52_RS25450	COG2177	Part of the ABC transporter FtsEX involved in
EXW52_RS25455	COG2884	Cell division ATP-binding protein ftsE
EXW52_RS25490	COG1278	Cold shock
EXW52_RS25495	COG1040	competence protein
EXW52_RS25500	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW52_RS25505	COG0791	NLP P60 protein
EXW52_RS25505	COG1388	LysM domain
EXW52_RS25510	COG1733	regulation of RNA biosynthetic process
EXW52_RS25515	COG1307	EDD domain protein, DegV family
EXW52_RS25520	COG1739	Uncharacterized protein family UPF0029
EXW52_RS25525	COG1316	TRANSCRIPTIONal
EXW52_RS25530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW52_RS25535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW52_RS25540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW52_RS25550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW52_RS25550	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW52_RS25570	COG1486	melibiose metabolic process
EXW52_RS25575	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW52_RS25580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW52_RS25590	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW52_RS25600	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW52_RS25610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW52_RS25615	COG1301	dicarboxylic acid transport
EXW52_RS25630	COG1511	domain protein
EXW52_RS25635	COG0583	DNA-binding transcription factor activity
EXW52_RS25640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW52_RS25650	COG1271	oxidase subunit
EXW52_RS25655	COG1294	oxidase, subunit
EXW52_RS25660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW52_RS25665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW52_RS25670	COG1620	l-lactate permease
EXW52_RS25680	COG2389	metal-binding protein
EXW52_RS25690	COG1368	sulfuric ester hydrolase activity
EXW52_RS25700	COG0791	NLP P60 protein
EXW52_RS25700	COG1388	LysM domain
EXW52_RS25705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW52_RS25715	COG1215	transferase activity, transferring glycosyl groups
EXW52_RS25720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW52_RS25725	COG1388	LysM domain
EXW52_RS25725	COG3584	3D domain protein
EXW52_RS25750	COG4715	Zinc finger, swim domain protein
EXW52_RS25755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW52_RS25795	COG0577	efflux transmembrane transporter activity
EXW52_RS25800	COG1136	(ABC) transporter
EXW52_RS25835	COG5002	protein histidine kinase activity
EXW52_RS25835	COG3850	Histidine kinase
EXW52_RS25840	COG0745	RESPONSE REGULATOR receiver
EXW52_RS25855	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EXW52_RS25865	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS25900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EXW52_RS25905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW52_RS25910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW52_RS25915	COG4464	protein tyrosine phosphatase activity
EXW52_RS25920	COG0489	protein tyrosine kinase activity
EXW52_RS25925	COG3944	biosynthesis protein
EXW52_RS25930	COG0489	protein tyrosine kinase activity
EXW52_RS25945	COG1609	Transcriptional regulator
EXW52_RS25955	COG0739	heme binding
EXW52_RS25970	COG3279	Response regulator of the LytR AlgR family
EXW52_RS25990	COG2385	sporulation resulting in formation of a cellular spore
EXW52_RS26005	COG4836	Membrane
EXW52_RS26010	COG1007	ATP synthesis coupled electron transport
EXW52_RS26015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW52_RS26020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW52_RS26025	COG0713	ATP synthesis coupled electron transport
EXW52_RS26030	COG0839	Belongs to the complex I subunit 6 family
EXW52_RS26040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW52_RS26045	COG0649	NAD binding
EXW52_RS26050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW52_RS26055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW52_RS26060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW52_RS26065	COG3300	MHYT domain
EXW52_RS26065	COG5001	Diguanylate cyclase
EXW52_RS26080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW52_RS26085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW52_RS26090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW52_RS26095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW52_RS26100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW52_RS26105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW52_RS26115	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW52_RS26140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW52_RS26150	COG0698	ribose 5-phosphate isomerase
EXW52_RS26160	COG2190	(PTS) system
EXW52_RS26165	COG2259	Doxx family
EXW52_RS26170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW52_RS26180	COG1971	Probably functions as a manganese efflux pump
EXW52_RS26185	COG0009	L-threonylcarbamoyladenylate synthase
EXW52_RS26200	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW52_RS26205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW52_RS26210	COG1435	thymidine kinase activity
EXW52_RS26220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW52_RS26230	COG1494	fructose-1,6-bisphosphatase
EXW52_RS26250	COG4821	SIS domain
EXW52_RS26255	COG0504	CTP synthase activity
EXW52_RS26260	COG3343	RNA polymerase activity
EXW52_RS26270	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS26275	COG1960	acyl-CoA dehydrogenase activity
EXW52_RS26280	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW52_RS26285	COG0183	Belongs to the thiolase family
EXW52_RS26290	COG0247	lactate metabolic process
EXW52_RS26290	COG2181	nitrate reductase activity
EXW52_RS26295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW52_RS26300	COG4294	response to UV
EXW52_RS26305	COG3300	MHYT domain
EXW52_RS26305	COG5001	Diguanylate cyclase
EXW52_RS26330	COG2197	response regulator
EXW52_RS26335	COG4585	Histidine kinase
EXW52_RS26340	COG0842	Transport permease protein
EXW52_RS26345	COG1131	(ABC) transporter
EXW52_RS26350	COG0024	Methionine aminopeptidase
EXW52_RS26360	COG2234	aminopeptidase activity
EXW52_RS26380	COG4506	Protein conserved in bacteria
EXW52_RS26385	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW52_RS26400	COG0010	Belongs to the arginase family
EXW52_RS26405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW52_RS26410	COG2814	Major facilitator Superfamily
EXW52_RS26415	COG0789	Transcriptional regulator
EXW52_RS26420	COG0584	glycerophosphoryl diester phosphodiesterase
EXW52_RS26425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW52_RS26435	COG1994	Peptidase M50
EXW52_RS26445	COG1078	dGTPase activity
EXW52_RS26450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW52_RS26455	COG1120	ATPase activity
EXW52_RS26460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS26465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW52_RS26470	COG4844	belongs to the
EXW52_RS26485	COG0280	phosphate acetyltransferase
EXW52_RS26490	COG3253	May function as heme-dependent peroxidase
EXW52_RS26500	COG3773	Cell wall hydrolase
EXW52_RS26510	COG2363	Small membrane protein
EXW52_RS26525	COG2233	PERMEase
EXW52_RS26530	COG0561	phosphatase activity
EXW52_RS26535	COG2814	Major facilitator Superfamily
EXW52_RS26540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW52_RS26545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW52_RS26550	COG1131	(ABC) transporter
EXW52_RS26555	COG2755	lipolytic protein G-D-S-L family
EXW52_RS26560	COG1609	Transcriptional regulator
EXW52_RS26570	COG0460	homoserine dehydrogenase
EXW52_RS26575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW52_RS26580	COG2873	o-acetylhomoserine
EXW52_RS26590	COG1011	Hydrolase
EXW52_RS26595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW52_RS26605	COG2197	response regulator
EXW52_RS26610	COG2203	Gaf domain
EXW52_RS26610	COG4585	Histidine kinase
EXW52_RS26615	COG0351	phosphomethylpyrimidine kinase
EXW52_RS26620	COG3706	GGDEF domain
EXW52_RS26625	COG2879	small protein
EXW52_RS26630	COG1966	Carbon starvation protein
EXW52_RS26635	COG3279	Response regulator of the LytR AlgR family
EXW52_RS26640	COG0477	Major facilitator Superfamily
EXW52_RS26665	COG0840	transmembrane signaling receptor activity
EXW52_RS26675	COG1607	acyl-coa hydrolase
EXW52_RS26680	COG1216	Glycosyl transferase, family 2
EXW52_RS26690	COG1216	Glycosyl transferase, family 2
EXW52_RS26700	COG0488	(ABC) transporter
EXW52_RS26705	COG1309	transcriptional regulator
EXW52_RS26710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW52_RS26715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW52_RS26715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW52_RS26720	COG0628	permease
EXW52_RS26730	COG1380	Effector of murein hydrolase LrgA
EXW52_RS26735	COG3279	Response regulator of the LytR AlgR family
EXW52_RS26740	COG3275	phosphorelay sensor kinase activity
EXW52_RS26745	COG2814	Major facilitator Superfamily
EXW52_RS26750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW52_RS26755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW52_RS26760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW52_RS26810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW52_RS26815	COG1272	protein, Hemolysin III
EXW52_RS26840	COG1164	Oligoendopeptidase f
EXW52_RS26915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW52_RS26925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW52_RS26930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW52_RS26935	COG4853	Protein conserved in bacteria
EXW52_RS26945	COG5002	protein histidine kinase activity
EXW52_RS26950	COG0745	RESPONSE REGULATOR receiver
EXW52_RS26980	COG0305	Participates in initiation and elongation during chromosome replication
EXW52_RS26985	COG0359	binds to the 23S rRNA
EXW52_RS26990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW52_RS26995	COG4241	membrane
EXW52_RS27005	COG0629	single-stranded DNA binding
EXW52_RS27010	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW52_RS27015	COG0012	GTP binding
EXW52_RS27020	COG4481	Protein conserved in bacteria
EXW52_RS27025	COG0668	transmembrane transport
EXW52_RS27035	COG1475	DNA binding
EXW52_RS27040	COG1192	Involved in chromosome partitioning
EXW52_RS27045	COG1475	DNA binding
EXW52_RS27050	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW52_RS27055	COG0445	tRNA wobble uridine modification
EXW52_RS27060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW52_RS27065	COG1847	R3H domain protein
EXW52_RS27070	COG0706	membrane insertase activity
EXW52_RS27075	COG0594	ribonuclease P activity
EXW52_RS27080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW52_RS27095	COG1278	Cold shock
EXW52_RS27100	COG0662	Cupin 2, conserved barrel domain protein
EXW52_RS27130	COG1136	(ABC) transporter
EXW52_RS27290	COG3620	sequence-specific DNA binding
EXW52_RS27300	COG0582	viral genome integration into host DNA
EXW52_RS27310	COG1192	Involved in chromosome partitioning
EXW52_RS27325	COG0024	Methionine aminopeptidase
EXW52_RS27330	COG1278	Cold shock
EXW52_RS27505	COG0791	NLP P60 protein
EXW52_RS27575	COG0551	DNA topoisomerase type I activity
EXW52_RS27575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW52_RS27660	COG0463	Glycosyl transferase, family 2
EXW52_RS27685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW52_RS27690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW52_RS27695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS27700	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS27720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS27725	COG0438	transferase activity, transferring glycosyl groups
EXW52_RS27730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW52_RS27825	COG3773	Cell wall hydrolase
EXW52_RS27915	COG1780	Probably involved in ribonucleotide reductase function
EXW52_RS27940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW52_RS27950	COG4166	transmembrane transport
EXW52_RS27980	COG1192	Involved in chromosome partitioning
EXW52_RS28000	COG0741	lytic transglycosylase activity
EXW52_RS28010	COG1674	ftsk spoiiie
EXW52_RS28025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW52_RS28065	COG5002	protein histidine kinase activity
EXW52_RS28095	COG2186	Transcriptional regulator
EXW52_RS28210	COG0791	NLP P60 protein
EXW52_RS28210	COG3883	PFAM NLP P60 protein
EXW52_RS28250	COG0024	Methionine aminopeptidase
EXW52_RS28280	COG2002	toxin-antitoxin pair type II binding
EXW52_RS28285	COG0662	Cupin 2, conserved barrel domain protein
EXW52_RS28295	COG1923	regulation of RNA biosynthetic process
EXW52_RS28300	COG0477	Major facilitator Superfamily
EXW52_RS28310	COG0425	Belongs to the sulfur carrier protein TusA family
EXW52_RS28310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW52_RS28315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW52_RS28350	COG2211	Major facilitator Superfamily
EXW52_RS28380	COG0582	viral genome integration into host DNA
EXW52_RS28390	COG2378	regulation of single-species biofilm formation
EXW52_RS28395	COG2318	DinB family
EXW52_RS28440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW52_RS28475	COG2814	Major facilitator Superfamily
EXW52_RS28500	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW52_RS28515	COG2814	Major facilitator Superfamily
EXW52_RS28520	COG2357	RelA SpoT domain protein
EXW52_RS28565	COG0367	asparagine synthase
EXW52_RS28610	COG0640	Transcriptional regulator
EXW52_RS28665	COG4977	sequence-specific DNA binding
EXW52_RS28680	COG0083	homoserine kinase activity
EXW52_RS28695	COG1309	transcriptional regulator
EXW52_RS28700	COG2814	Major facilitator Superfamily
EXW52_RS28755	COG0814	amino acid
EXW52_RS28760	COG0697	spore germination
EXW52_RS28770	COG1760	l-serine dehydratase
EXW52_RS28775	COG1760	l-serine dehydratase
EXW52_RS28780	COG0814	amino acid
EXW52_RS28810	COG0697	spore germination
EXW52_RS28855	COG1396	sequence-specific DNA binding
EXW52_RS28875	COG0840	transmembrane signaling receptor activity
EXW52_RS28880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW52_RS28920	COG4974	Belongs to the 'phage' integrase family
EXW52_RS28940	COG1725	Transcriptional regulator
EXW52_RS28945	COG1131	(ABC) transporter
EXW52_RS28980	COG1329	Transcriptional regulator
EXW52_RS29075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW52_RS29075	COG2755	lipolytic protein G-D-S-L family
EXW52_RS29110	COG0745	RESPONSE REGULATOR receiver
EXW52_RS29130	COG2720	vancomycin resistance protein
EXW52_RS29145	COG0833	amino acid
EXW52_RS29150	COG2040	homocysteine
EXW52_RS29235	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW52_RS29250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW52_RS29360	COG1404	Belongs to the peptidase S8 family
EXW52_RS29370	COG2814	Major facilitator Superfamily
EXW52_RS29375	COG2234	aminopeptidase activity
EXW52_RS29405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW52_RS29410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW52_RS29420	COG0456	acetyltransferase
EXW52_RS29435	COG1278	Cold shock
EXW52_RS29695	COG1783	phage Terminase large subunit
EXW52_RS29760	COG2076	Multidrug Resistance protein