locus-tag	class	description
EXW49_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW49_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW49_RS00015	COG2501	S4 domain
EXW49_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW49_RS00025	COG0187	DNA topoisomerase II activity
EXW49_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW49_RS00065	COG0517	IMP dehydrogenase activity
EXW49_RS00065	COG0516	GMP reductase activity
EXW49_RS00070	COG1686	Belongs to the peptidase S11 family
EXW49_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW49_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW49_RS00100	COG1428	Deoxynucleoside kinase
EXW49_RS00105	COG1428	Deoxynucleoside kinase
EXW49_RS00110	COG1335	isochorismatase
EXW49_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW49_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW49_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW49_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW49_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW49_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW49_RS00190	COG0470	DNA polymerase III
EXW49_RS00195	COG1774	PSP1 C-terminal conserved region
EXW49_RS00200	COG4467	Involved in initiation control of chromosome replication
EXW49_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW49_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW49_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW49_RS00230	COG0084	hydrolase, TatD family'
EXW49_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW49_RS00250	COG4466	Protein conserved in bacteria
EXW49_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW49_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW49_RS00270	COG0251	oxidation-reduction process
EXW49_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW49_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW49_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW49_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW49_RS00310	COG2244	polysaccharide biosynthetic process
EXW49_RS00315	COG3956	TIGRFAM MazG family protein
EXW49_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW49_RS00340	COG1098	S1 RNA binding domain
EXW49_RS00355	COG2208	phosphoserine phosphatase activity
EXW49_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW49_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW49_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW49_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW49_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW49_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW49_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW49_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW49_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW49_RS00420	COG1396	sequence-specific DNA binding
EXW49_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW49_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW49_RS00515	COG3880	PFAM UvrB UvrC protein
EXW49_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW49_RS00525	COG0542	response to heat
EXW49_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW49_RS00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW49_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW49_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW49_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW49_RS00560	COG1045	serine acetyltransferase
EXW49_RS00565	COG0215	cysteine-tRNA ligase activity
EXW49_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW49_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW49_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW49_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW49_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW49_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW49_RS00610	COG0081	regulation of translation
EXW49_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW49_RS00620	COG0222	ribosome binding
EXW49_RS00625	COG2813	Specifically methylates the guanine in position
EXW49_RS00630	COG0085	RNA polymerase activity
EXW49_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW49_RS00640	COG1358	cellular component organization or biogenesis
EXW49_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW49_RS00650	COG0049	tRNA binding
EXW49_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW49_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW49_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW49_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW49_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EXW49_RS00680	COG0089	rRNA binding
EXW49_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW49_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW49_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW49_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW49_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW49_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW49_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW49_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW49_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW49_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW49_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW49_RS00760	COG1841	ribosomal large subunit assembly
EXW49_RS00765	COG0200	Binds to the 23S rRNA
EXW49_RS00770	COG0201	protein transport
EXW49_RS00775	COG0563	adenylate kinase activity
EXW49_RS00780	COG0024	Methionine aminopeptidase
EXW49_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW49_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW49_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW49_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW49_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW49_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW49_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS00855	COG0489	protein tyrosine kinase activity
EXW49_RS00865	COG2194	sulfuric ester hydrolase activity
EXW49_RS00870	COG0726	polysaccharide deacetylase
EXW49_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW49_RS00955	COG4856	YbbR-like protein
EXW49_RS00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW49_RS00970	COG4946	Tricorn protease homolog
EXW49_RS00970	COG1506	peptidase
EXW49_RS00970	COG0823	Involved in the tonB-independent uptake of proteins
EXW49_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS00985	COG2011	ABC-type metal ion transport system permease component
EXW49_RS00995	COG1464	Belongs to the NlpA lipoprotein family
EXW49_RS01000	COG0604	alcohol dehydrogenase
EXW49_RS01010	COG0277	FAD linked oxidase domain protein
EXW49_RS01015	COG2271	Major facilitator Superfamily
EXW49_RS01025	COG2814	Major facilitator Superfamily
EXW49_RS01040	COG0601	transmembrane transport
EXW49_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_RS01050	COG0444	Belongs to the ABC transporter superfamily
EXW49_RS01055	COG4608	Belongs to the ABC transporter superfamily
EXW49_RS01060	COG4166	transmembrane transport
EXW49_RS01070	COG2207	Transcriptional regulator
EXW49_RS01085	COG4166	transmembrane transport
EXW49_RS01090	COG4166	transmembrane transport
EXW49_RS01095	COG0656	L-ascorbic acid biosynthetic process
EXW49_RS01100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_RS01115	COG4149	molybdate abc transporter
EXW49_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW49_RS01125	COG1910	domain protein
EXW49_RS01140	COG0697	spore germination
EXW49_RS01155	COG0204	Acyl-transferase
EXW49_RS01165	COG1609	Transcriptional regulator
EXW49_RS01175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS01190	COG5298	Protein conserved in bacteria
EXW49_RS01210	COG0488	(ABC) transporter
EXW49_RS01215	COG4585	Histidine kinase
EXW49_RS01220	COG2197	response regulator
EXW49_RS01225	COG1131	(ABC) transporter
EXW49_RS01230	COG0842	Transport permease protein
EXW49_RS01230	COG1511	domain protein
EXW49_RS01235	COG0842	Transport permease protein
EXW49_RS01250	COG0601	transmembrane transport
EXW49_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_RS01260	COG0444	Belongs to the ABC transporter superfamily
EXW49_RS01265	COG4608	Belongs to the ABC transporter superfamily
EXW49_RS01270	COG0561	phosphatase activity
EXW49_RS01300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW49_RS01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW49_RS01315	COG2814	Major facilitator Superfamily
EXW49_RS01325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW49_RS01335	COG4294	response to UV
EXW49_RS01340	COG0705	Rhomboid family
EXW49_RS01345	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW49_RS01350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW49_RS01355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW49_RS01360	COG0864	Transcriptional regulator
EXW49_RS01365	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW49_RS01370	COG2183	response to ionizing radiation
EXW49_RS01470	COG0802	atpase or kinase
EXW49_RS01475	COG1214	PFAM Peptidase M22, glycoprotease
EXW49_RS01480	COG0456	acetyltransferase
EXW49_RS01490	COG0488	(ABC) transporter
EXW49_RS01495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW49_RS01505	COG1266	CAAX protease self-immunity
EXW49_RS01510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW49_RS01515	COG0459	protein refolding
EXW49_RS01520	COG0519	Catalyzes the synthesis of GMP from XMP
EXW49_RS01520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW49_RS01570	COG2252	PERMEase
EXW49_RS01580	COG5002	protein histidine kinase activity
EXW49_RS01605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_RS01635	COG2226	methyltransferase
EXW49_RS01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_RS01655	COG1215	transferase activity, transferring glycosyl groups
EXW49_RS01680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS01685	COG0506	proline dehydrogenase activity
EXW49_RS01705	COG0697	spore germination
EXW49_RS01730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW49_RS01735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW49_RS01740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW49_RS01745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW49_RS01750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW49_RS01755	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW49_RS01760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW49_RS01765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW49_RS01770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW49_RS01775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW49_RS01780	COG0138	bifunctional purine biosynthesis protein purh
EXW49_RS01785	COG0151	Belongs to the GarS family
EXW49_RS01805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW49_RS01810	COG0210	DNA helicase
EXW49_RS01815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW49_RS01820	COG4851	CamS sex pheromone cAM373 precursor
EXW49_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS01835	COG1335	isochorismatase
EXW49_RS01845	COG2011	ABC-type metal ion transport system permease component
EXW49_RS01850	COG1464	Belongs to the NlpA lipoprotein family
EXW49_RS01865	COG0003	Pfam Anion-transporting ATPase
EXW49_RS01870	COG1846	Transcriptional regulator
EXW49_RS01875	COG4682	membrane
EXW49_RS01885	COG0154	amidase activity
EXW49_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW49_RS01895	COG1597	lipid kinase activity
EXW49_RS01900	COG0546	phosphoglycolate phosphatase activity
EXW49_RS01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW49_RS01920	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS01925	COG2076	Multidrug Resistance protein
EXW49_RS01930	COG2309	aminopeptidase activity
EXW49_RS01945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS01955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW49_RS01960	COG5002	protein histidine kinase activity
EXW49_RS01965	COG4807	Protein conserved in bacteria
EXW49_RS01990	COG1757	Na H antiporter
EXW49_RS01995	COG1473	amidohydrolase
EXW49_RS02010	COG0450	alkyl hydroperoxide reductase
EXW49_RS02020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW49_RS02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS02035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS02040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS02045	COG0492	ferredoxin-NADP+ reductase activity
EXW49_RS02055	COG0166	Belongs to the GPI family
EXW49_RS02100	COG3541	Predicted nucleotidyltransferase
EXW49_RS02105	COG2814	Major facilitator Superfamily
EXW49_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
EXW49_RS02110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_RS02120	COG0765	amino acid transport
EXW49_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS02135	COG0840	transmembrane signaling receptor activity
EXW49_RS02160	COG0549	Belongs to the carbamate kinase family
EXW49_RS02175	COG0277	FAD linked oxidase domain protein
EXW49_RS02180	COG0366	Alpha amylase catalytic
EXW49_RS02185	COG1263	PTS System
EXW49_RS02185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_RS02185	COG2190	(PTS) system
EXW49_RS02205	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW49_RS02210	COG0352	thiamine-phosphate diphosphorylase activity
EXW49_RS02215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW49_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_RS02235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_RS02240	COG1116	anion transmembrane transporter activity
EXW49_RS02245	COG0488	(ABC) transporter
EXW49_RS02280	COG2270	Major facilitator Superfamily
EXW49_RS02310	COG2310	stress, protein
EXW49_RS02315	COG2310	stress, protein
EXW49_RS02320	COG2310	stress, protein
EXW49_RS02325	COG0861	Integral membrane protein TerC family
EXW49_RS02335	COG3853	Toxic anion resistance protein (TelA)
EXW49_RS02345	COG4840	Belongs to the UPF0435 family
EXW49_RS02350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW49_RS02360	COG1295	ribonuclease BN
EXW49_RS02365	COG2217	Heavy metal translocating P-type atpase
EXW49_RS02370	COG0697	spore germination
EXW49_RS02390	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS02405	COG3871	stress protein (general stress protein 26)
EXW49_RS02410	COG0387	Pfam Sodium calcium exchanger
EXW49_RS02420	COG0535	radical SAM domain protein
EXW49_RS02440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW49_RS02460	COG3829	transcription factor binding
EXW49_RS02470	COG0833	amino acid
EXW49_RS02475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_RS02495	COG2066	Belongs to the glutaminase family
EXW49_RS02500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_RS02500	COG1263	PTS System
EXW49_RS02505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS02520	COG1216	Glycosyl transferase, family 2
EXW49_RS02530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_RS02530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW49_RS02535	COG0463	Glycosyl transferase, family 2
EXW49_RS02550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW49_RS02555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW49_RS02570	COG1228	amidohydrolase
EXW49_RS02575	COG1090	epimerase
EXW49_RS02580	COG2137	regulation of response to DNA damage stimulus
EXW49_RS02605	COG1988	membrane-bound metal-dependent
EXW49_RS02610	COG1194	a g-specific adenine glycosylase
EXW49_RS02630	COG3557	Belongs to the UPF0374 family
EXW49_RS02635	COG1132	(ABC) transporter
EXW49_RS02640	COG4129	membrane
EXW49_RS02645	COG0067	glutamate synthase
EXW49_RS02645	COG0069	glutamate synthase activity
EXW49_RS02645	COG0070	glutamate synthase
EXW49_RS02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW49_RS02655	COG4555	ABC transporter
EXW49_RS02675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW49_RS02680	COG0735	belongs to the Fur family
EXW49_RS02800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW49_RS02805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW49_RS02825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW49_RS02830	COG5001	Diguanylate cyclase
EXW49_RS02830	COG1716	ATPase activity
EXW49_RS02835	COG2766	serine protein kinase
EXW49_RS02840	COG2718	Belongs to the UPF0229 family
EXW49_RS02855	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW49_RS02860	COG2268	Band 7 protein
EXW49_RS02870	COG3290	protein histidine kinase activity
EXW49_RS02875	COG4565	transcriptional regulatory protein
EXW49_RS02880	COG2851	Citrate transporter
EXW49_RS02905	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW49_RS02910	COG3842	ATPase activity
EXW49_RS02915	COG1175	transmembrane transport
EXW49_RS02920	COG0395	ABC-type sugar transport system, permease component
EXW49_RS02930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW49_RS02935	COG0745	RESPONSE REGULATOR receiver
EXW49_RS02940	COG5002	protein histidine kinase activity
EXW49_RS02950	COG4990	cell redox homeostasis
EXW49_RS02960	COG3290	protein histidine kinase activity
EXW49_RS02965	COG4565	transcriptional regulatory protein
EXW49_RS02970	COG3493	citrate carrier protein
EXW49_RS02975	COG0281	malic enzyme
EXW49_RS02985	COG0697	spore germination
EXW49_RS02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS03000	COG5002	protein histidine kinase activity
EXW49_RS03005	COG0745	RESPONSE REGULATOR receiver
EXW49_RS03010	COG0456	acetyltransferase
EXW49_RS03015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW49_RS03020	COG3383	formate dehydrogenase (NAD+) activity
EXW49_RS03025	COG2427	Protein of unknown function (DUF1641)
EXW49_RS03040	COG0531	amino acid
EXW49_RS03050	COG0640	Transcriptional regulator
EXW49_RS03055	COG2217	Heavy metal translocating P-type atpase
EXW49_RS03060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW49_RS03075	COG3227	Zinc metalloprotease (Elastase)
EXW49_RS03095	COG2720	vancomycin resistance protein
EXW49_RS03100	COG1316	TRANSCRIPTIONal
EXW49_RS03105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS03110	COG0346	lactoylglutathione lyase activity
EXW49_RS03115	COG1253	flavin adenine dinucleotide binding
EXW49_RS03120	COG1027	Aspartate ammonia-lyase
EXW49_RS03125	COG1620	l-lactate permease
EXW49_RS03130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS03145	COG3104	oligopeptide transport
EXW49_RS03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS03175	COG0156	8-amino-7-oxononanoate synthase activity
EXW49_RS03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_RS03190	COG4548	von Willebrand factor, type A
EXW49_RS03195	COG0714	Associated with various cellular activities
EXW49_RS03220	COG2801	Transposase and inactivated derivatives
EXW49_RS03225	COG0531	amino acid
EXW49_RS03230	COG2188	Transcriptional regulator
EXW49_RS03235	COG1263	PTS System
EXW49_RS03235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_RS03240	COG0366	Alpha amylase catalytic
EXW49_RS03255	COG0697	spore germination
EXW49_RS03260	COG4585	Histidine kinase
EXW49_RS03265	COG2197	response regulator
EXW49_RS03270	COG1404	Belongs to the peptidase S8 family
EXW49_RS03285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_RS03290	COG1115	amino acid carrier protein
EXW49_RS03295	COG1126	abc transporter atp-binding protein
EXW49_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS03305	COG0765	amino acid transport
EXW49_RS03310	COG0765	amino acid transport
EXW49_RS03315	COG0833	amino acid
EXW49_RS03345	COG2378	regulation of single-species biofilm formation
EXW49_RS03350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW49_RS03355	COG5002	protein histidine kinase activity
EXW49_RS03370	COG0659	secondary active sulfate transmembrane transporter activity
EXW49_RS03395	COG0601	transmembrane transport
EXW49_RS03400	COG4608	Belongs to the ABC transporter superfamily
EXW49_RS03410	COG2271	Major facilitator Superfamily
EXW49_RS03415	COG1846	Transcriptional regulator
EXW49_RS03420	COG0477	Major facilitator Superfamily
EXW49_RS03425	COG1609	Transcriptional regulator
EXW49_RS03430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW49_RS03435	COG1869	D-ribose catabolic process
EXW49_RS03445	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW49_RS03450	COG1879	ABC-type sugar transport system periplasmic component
EXW49_RS03470	COG1063	alcohol dehydrogenase
EXW49_RS03515	COG0840	transmembrane signaling receptor activity
EXW49_RS03520	COG3584	3D domain protein
EXW49_RS03520	COG3583	domain protein
EXW49_RS03525	COG1476	TRANSCRIPTIONal
EXW49_RS03545	COG3104	oligopeptide transport
EXW49_RS03550	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS03565	COG1113	amino acid transport
EXW49_RS03570	COG2252	PERMEase
EXW49_RS03585	COG2153	protein acetylation
EXW49_RS03595	COG0475	glutathione-regulated potassium exporter activity
EXW49_RS03595	COG0569	domain protein
EXW49_RS03605	COG1845	cytochrome c oxidase, subunit III
EXW49_RS03610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW49_RS03620	COG0833	amino acid
EXW49_RS03625	COG4990	cell redox homeostasis
EXW49_RS03640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_RS03645	COG0697	spore germination
EXW49_RS03650	COG0531	amino acid
EXW49_RS03660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW49_RS03665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW49_RS03675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW49_RS03680	COG0573	inorganic phosphate transmembrane transporter activity
EXW49_RS03685	COG0581	inorganic phosphate transmembrane transporter activity
EXW49_RS03690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW49_RS03810	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW49_RS03825	COG4991	sh3 domain protein
EXW49_RS03825	COG3103	Sh3 type 3 domain protein
EXW49_RS03825	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS03830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW49_RS03835	COG1116	anion transmembrane transporter activity
EXW49_RS03840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_RS03845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_RS03850	COG0352	thiamine-phosphate diphosphorylase activity
EXW49_RS03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_RS03860	COG2104	thiamine diphosphate biosynthetic process
EXW49_RS03870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_RS03875	COG0351	phosphomethylpyrimidine kinase
EXW49_RS03905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW49_RS03910	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW49_RS03915	COG2205	protein histidine kinase activity
EXW49_RS03920	COG2814	Major facilitator Superfamily
EXW49_RS03925	COG1846	Transcriptional regulator
EXW49_RS03945	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW49_RS03950	COG1129	ABC transporter
EXW49_RS03955	COG1879	ABC-type sugar transport system periplasmic component
EXW49_RS03960	COG2252	PERMEase
EXW49_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS04025	COG0778	Nitroreductase
EXW49_RS04030	COG2719	SpoVR family
EXW49_RS04050	COG1937	Protein conserved in bacteria
EXW49_RS04055	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_RS04055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS04060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS04065	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_RS04070	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_RS04070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS04075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS04080	COG2210	Belongs to the sulfur carrier protein TusA family
EXW49_RS04085	COG0730	response to heat
EXW49_RS04095	COG1316	TRANSCRIPTIONal
EXW49_RS04100	COG0604	alcohol dehydrogenase
EXW49_RS04105	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW49_RS04115	COG2814	Major facilitator Superfamily
EXW49_RS04125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_RS04125	COG3711	transcriptional antiterminator
EXW49_RS04130	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_RS04135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_RS04155	COG3584	3D domain protein
EXW49_RS04155	COG1388	LysM domain
EXW49_RS04160	COG0577	efflux transmembrane transporter activity
EXW49_RS04165	COG1136	(ABC) transporter
EXW49_RS04175	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW49_RS04190	COG0577	efflux transmembrane transporter activity
EXW49_RS04195	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS04200	COG3546	catalase activity
EXW49_RS04225	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS04255	COG0531	amino acid
EXW49_RS04270	COG1737	Transcriptional regulator
EXW49_RS04275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW49_RS04280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_RS04280	COG1263	PTS System
EXW49_RS04290	COG2259	Doxx family
EXW49_RS04310	COG0697	spore germination
EXW49_RS04315	COG1522	sequence-specific DNA binding
EXW49_RS04325	COG0300	oxidoreductase activity
EXW49_RS04340	COG2076	Multidrug Resistance protein
EXW49_RS04345	COG1309	transcriptional regulator
EXW49_RS04350	COG2814	Major facilitator Superfamily
EXW49_RS04355	COG1733	regulation of RNA biosynthetic process
EXW49_RS04370	COG4533	DNA binding
EXW49_RS04375	COG2211	Major facilitator Superfamily
EXW49_RS04390	COG0531	amino acid
EXW49_RS04395	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS04400	COG1132	(ABC) transporter
EXW49_RS04405	COG1132	(ABC) transporter
EXW49_RS04410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS04415	COG0765	amino acid transport
EXW49_RS04420	COG1126	abc transporter atp-binding protein
EXW49_RS04435	COG0189	ligase activity
EXW49_RS04445	COG4399	Belongs to the UPF0754 family
EXW49_RS04450	COG3679	Belongs to the UPF0342 family
EXW49_RS04465	COG0028	Belongs to the TPP enzyme family
EXW49_RS04470	COG3527	Alpha-acetolactate decarboxylase
EXW49_RS04475	COG0463	Glycosyl transferase, family 2
EXW49_RS04480	COG1216	Glycosyl transferase, family 2
EXW49_RS04485	COG2094	Belongs to the DNA glycosylase MPG family
EXW49_RS04490	COG0561	phosphatase activity
EXW49_RS04495	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_RS04495	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS04500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW49_RS04505	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS04510	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS04520	COG0789	Transcriptional regulator
EXW49_RS04520	COG4978	Transcriptional regulator
EXW49_RS04530	COG0659	secondary active sulfate transmembrane transporter activity
EXW49_RS04545	COG0653	protein targeting
EXW49_RS04550	COG2244	polysaccharide biosynthetic process
EXW49_RS04560	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS04565	COG4196	transglutaminase domain protein
EXW49_RS04580	COG1696	Membrane protein involved in D-alanine export
EXW49_RS04595	COG1024	Enoyl-CoA hydratase
EXW49_RS04610	COG1363	Peptidase, m42
EXW49_RS04625	COG2318	DinB family
EXW49_RS04645	COG0579	oxidoreductase
EXW49_RS04680	COG0601	transmembrane transport
EXW49_RS04685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_RS04690	COG0444	Belongs to the ABC transporter superfamily
EXW49_RS04695	COG4608	Belongs to the ABC transporter superfamily
EXW49_RS04790	COG0477	Major facilitator Superfamily
EXW49_RS04795	COG3290	protein histidine kinase activity
EXW49_RS04800	COG4565	transcriptional regulatory protein
EXW49_RS04805	COG3181	Tripartite tricarboxylate transporter family receptor
EXW49_RS04810	COG0494	nUDIX hydrolase
EXW49_RS04850	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_RS04880	COG0477	Major facilitator Superfamily
EXW49_RS04970	COG2732	(Barnase) inhibitor
EXW49_RS04975	COG2814	Major facilitator Superfamily
EXW49_RS04980	COG0640	Transcriptional regulator
EXW49_RS05015	COG2376	Dihydroxyacetone kinase
EXW49_RS05025	COG2376	Dihydroxyacetone kinase
EXW49_RS05035	COG2720	vancomycin resistance protein
EXW49_RS05090	COG1846	Transcriptional regulator
EXW49_RS05095	COG0825	malonyl-CoA metabolic process
EXW49_RS05120	COG2807	transmembrane transport
EXW49_RS05135	COG4585	Histidine kinase
EXW49_RS05140	COG2197	response regulator
EXW49_RS05170	COG0420	3'-5' exonuclease activity
EXW49_RS05175	COG4717	serine-type aminopeptidase activity
EXW49_RS05180	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW49_RS05185	COG0346	lactoylglutathione lyase activity
EXW49_RS05190	COG0457	Tetratricopeptide repeat
EXW49_RS05200	COG2267	carboxylic ester hydrolase activity
EXW49_RS05215	COG3620	sequence-specific DNA binding
EXW49_RS05220	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW49_RS05225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW49_RS05230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW49_RS05235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW49_RS05240	COG1595	DNA-templated transcription, initiation
EXW49_RS05260	COG3973	AAA domain
EXW49_RS05265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_RS05290	COG0537	adenosine 5'-monophosphoramidase activity
EXW49_RS05295	COG1131	(ABC) transporter
EXW49_RS05300	COG4473	ABC transporter
EXW49_RS05310	COG0247	lactate metabolic process
EXW49_RS05315	COG1139	Iron-sulfur cluster binding protein
EXW49_RS05320	COG1556	Lactate utilization protein
EXW49_RS05355	COG3402	PFAM membrane-flanked domain
EXW49_RS05360	COG3428	Bacterial PH domain
EXW49_RS05400	COG3402	PFAM membrane-flanked domain
EXW49_RS05405	COG3428	Bacterial PH domain
EXW49_RS05410	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_RS05415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_RS05420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW49_RS05425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW49_RS05430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW49_RS05450	COG1309	transcriptional regulator
EXW49_RS05455	COG1511	domain protein
EXW49_RS05500	COG1609	Transcriptional regulator
EXW49_RS05510	COG1234	tRNA 3'-trailer cleavage
EXW49_RS05515	COG0095	Lipoate-protein ligase
EXW49_RS05525	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS05540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW49_RS05550	COG4208	sulfate ABC transporter
EXW49_RS05565	COG1408	metallophosphoesterase
EXW49_RS05570	COG1078	dGTPase activity
EXW49_RS05585	COG1595	DNA-templated transcription, initiation
EXW49_RS05590	COG2207	Transcriptional regulator
EXW49_RS05590	COG3708	Transcriptional regulator
EXW49_RS05595	COG2205	protein histidine kinase activity
EXW49_RS05600	COG0745	RESPONSE REGULATOR receiver
EXW49_RS05615	COG0501	Belongs to the peptidase M48B family
EXW49_RS05620	COG0840	transmembrane signaling receptor activity
EXW49_RS05625	COG0697	spore germination
EXW49_RS05650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW49_RS05655	COG2224	Isocitrate lyase
EXW49_RS05665	COG1278	Cold shock
EXW49_RS05675	COG4903	ComK protein
EXW49_RS05685	COG0398	Pfam SNARE associated Golgi protein
EXW49_RS05695	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW49_RS05700	COG1074	ATP-dependent DNA helicase activity
EXW49_RS05750	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW49_RS05775	COG0367	asparagine synthase
EXW49_RS05785	COG0753	catalase activity
EXW49_RS05790	COG0004	ammonium transporteR
EXW49_RS05800	COG1666	GTP binding
EXW49_RS05805	COG2996	Protein conserved in bacteria
EXW49_RS05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_RS05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS05840	COG0561	phosphatase activity
EXW49_RS05860	COG2267	carboxylic ester hydrolase activity
EXW49_RS05875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_RS05880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW49_RS05885	COG5504	Zn-dependent protease
EXW49_RS05895	COG0180	Tryptophanyl-tRNA synthetase
EXW49_RS05905	COG4166	transmembrane transport
EXW49_RS05910	COG0601	transmembrane transport
EXW49_RS05915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_RS05920	COG0444	Belongs to the ABC transporter superfamily
EXW49_RS05925	COG4608	Belongs to the ABC transporter superfamily
EXW49_RS05930	COG0534	Mate efflux family protein
EXW49_RS05935	COG4166	transmembrane transport
EXW49_RS05950	COG0861	Integral membrane protein TerC family
EXW49_RS05955	COG4862	establishment of competence for transformation
EXW49_RS05960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_RS05970	COG1164	Oligoendopeptidase f
EXW49_RS05985	COG2346	COG2346, Truncated hemoglobins
EXW49_RS05990	COG4116	CYTH
EXW49_RS06000	COG2357	RelA SpoT domain protein
EXW49_RS06010	COG0564	pseudouridine synthase activity
EXW49_RS06020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW49_RS06025	COG0772	Belongs to the SEDS family
EXW49_RS06030	COG1216	Glycosyl transferase, family 2
EXW49_RS06050	COG0457	Tetratricopeptide repeat
EXW49_RS06050	COG0463	Glycosyl transferase, family 2
EXW49_RS06070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW49_RS06085	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW49_RS06130	COG2153	protein acetylation
EXW49_RS06135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW49_RS06140	COG2382	esterase
EXW49_RS06165	COG5492	domain, Protein
EXW49_RS06170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_RS06180	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW49_RS06180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW49_RS06185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW49_RS06190	COG0134	indole-3-glycerol-phosphate synthase activity
EXW49_RS06195	COG0135	phosphoribosylanthranilate isomerase activity
EXW49_RS06200	COG0133	tryptophan synthase activity
EXW49_RS06205	COG0159	tryptophan synthase activity
EXW49_RS06215	COG1620	l-lactate permease
EXW49_RS06220	COG5634	Uncharacterized conserved protein (DUF2278)
EXW49_RS06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_RS06305	COG0567	Dehydrogenase, E1 component
EXW49_RS06310	COG1476	TRANSCRIPTIONal
EXW49_RS06335	COG4152	abc transporter atp-binding protein
EXW49_RS06340	COG1668	transmembrane transport
EXW49_RS06360	COG1686	Belongs to the peptidase S11 family
EXW49_RS06365	COG0681	Belongs to the peptidase S26 family
EXW49_RS06375	COG2801	Transposase and inactivated derivatives
EXW49_RS06410	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS06420	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW49_RS06425	COG1177	transmembrane transport
EXW49_RS06430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW49_RS06440	COG2409	Drug exporters of the RND superfamily
EXW49_RS06450	COG0564	pseudouridine synthase activity
EXW49_RS06460	COG2340	Cysteine-rich secretory protein family
EXW49_RS06465	COG0247	lactate metabolic process
EXW49_RS06470	COG0277	FAD linked oxidase domain protein
EXW49_RS06475	COG3835	regulator
EXW49_RS06485	COG0745	RESPONSE REGULATOR receiver
EXW49_RS06490	COG5002	protein histidine kinase activity
EXW49_RS06495	COG2186	Transcriptional regulator
EXW49_RS06500	COG0247	lactate metabolic process
EXW49_RS06505	COG1139	Iron-sulfur cluster binding protein
EXW49_RS06510	COG1556	Lactate utilization protein
EXW49_RS06515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW49_RS06525	COG2116	formate transmembrane transporter activity
EXW49_RS06530	COG0861	Integral membrane protein TerC family
EXW49_RS06535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_RS06545	COG2030	dehydratase
EXW49_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS06570	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW49_RS06580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_RS06595	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW49_RS06600	COG3842	ATPase activity
EXW49_RS06610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW49_RS06615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW49_RS06625	COG1349	DNA-binding transcription factor activity
EXW49_RS06635	COG0235	Class ii aldolase
EXW49_RS06645	COG2861	carbohydrate metabolic process
EXW49_RS06655	COG3852	Histidine kinase
EXW49_RS06660	COG1846	Transcriptional regulator
EXW49_RS06670	COG2318	DinB family
EXW49_RS06675	COG5002	protein histidine kinase activity
EXW49_RS06680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW49_RS06685	COG0720	synthase
EXW49_RS06695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW49_RS06700	COG4873	Protein conserved in bacteria
EXW49_RS06720	COG2801	Transposase and inactivated derivatives
EXW49_RS06725	COG0456	acetyltransferase
EXW49_RS06740	COG1780	Probably involved in ribonucleotide reductase function
EXW49_RS06755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW49_RS06760	COG0531	amino acid
EXW49_RS06770	COG3290	protein histidine kinase activity
EXW49_RS06770	COG3829	transcription factor binding
EXW49_RS06775	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS06785	COG1725	Transcriptional regulator
EXW49_RS06790	COG1131	(ABC) transporter
EXW49_RS06800	COG1131	(ABC) transporter
EXW49_RS06805	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_RS06810	COG1266	CAAX protease self-immunity
EXW49_RS06820	COG1522	sequence-specific DNA binding
EXW49_RS06830	COG1335	isochorismatase
EXW49_RS06840	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_RS06845	COG2070	2-Nitropropane dioxygenase
EXW49_RS06850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW49_RS06855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_RS06860	COG1696	Membrane protein involved in D-alanine export
EXW49_RS06865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW49_RS06885	COG0716	FMN binding
EXW49_RS06920	COG0534	Mate efflux family protein
EXW49_RS06925	COG1968	undecaprenyl-diphosphatase activity
EXW49_RS06945	COG1846	Transcriptional regulator
EXW49_RS06955	COG1301	dicarboxylic acid transport
EXW49_RS06960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_RS06970	COG3874	Sporulation protein YtfJ
EXW49_RS06990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_RS06995	COG0028	Belongs to the TPP enzyme family
EXW49_RS07000	COG0440	acetolactate synthase activity
EXW49_RS07010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW49_RS07020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW49_RS07030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW49_RS07035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW49_RS07045	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW49_RS07050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW49_RS07055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW49_RS07060	COG0107	imidazoleglycerol-phosphate synthase activity
EXW49_RS07070	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW49_RS07075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW49_RS07090	COG1183	phosphatidylcholine synthase activity
EXW49_RS07095	COG1368	sulfuric ester hydrolase activity
EXW49_RS07105	COG0019	diaminopimelate decarboxylase activity
EXW49_RS07115	COG0175	sulfate reduction
EXW49_RS07120	COG2046	Belongs to the sulfate adenylyltransferase family
EXW49_RS07125	COG0529	Catalyzes the synthesis of activated sulfate
EXW49_RS07130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW49_RS07150	COG1648	precorrin-2 dehydrogenase activity
EXW49_RS07155	COG0733	neurotransmitter:sodium symporter activity
EXW49_RS07180	COG1757	Na H antiporter
EXW49_RS07200	COG4758	membrane
EXW49_RS07205	COG4585	Histidine kinase
EXW49_RS07210	COG2197	response regulator
EXW49_RS07220	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS07230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW49_RS07270	COG0730	response to heat
EXW49_RS07275	COG0306	phosphate transporter
EXW49_RS07280	COG1392	Phosphate transport regulator
EXW49_RS07285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_RS07300	COG3852	Histidine kinase
EXW49_RS07305	COG1801	Protein of unknown function DUF72
EXW49_RS07315	COG0582	viral genome integration into host DNA
EXW49_RS07320	COG5002	protein histidine kinase activity
EXW49_RS07335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW49_RS07335	COG0392	lysyltransferase activity
EXW49_RS07350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_RS07355	COG1686	Belongs to the peptidase S11 family
EXW49_RS07360	COG2715	membrane protein required for spore maturation
EXW49_RS07365	COG0700	Nucleoside recognition
EXW49_RS07370	COG1187	pseudouridine synthase activity
EXW49_RS07380	COG1333	cytochrome c biogenesis protein
EXW49_RS07385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW49_RS07390	COG0745	RESPONSE REGULATOR receiver
EXW49_RS07395	COG5002	protein histidine kinase activity
EXW49_RS07400	COG2096	Adenosyltransferase
EXW49_RS07405	COG4942	peptidase
EXW49_RS07415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW49_RS07420	COG1141	Ferredoxin
EXW49_RS07425	COG4955	Helix-turn-helix domain
EXW49_RS07430	COG0514	ATP-dependent DNA helicase (RecQ)
EXW49_RS07435	COG1266	CAAX protease self-immunity
EXW49_RS07445	COG1408	metallophosphoesterase
EXW49_RS07460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW49_RS07480	COG0492	ferredoxin-NADP+ reductase activity
EXW49_RS07485	COG0252	asparaginase activity
EXW49_RS07495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW49_RS07505	COG1304	FMN binding
EXW49_RS07535	COG1160	GTP binding
EXW49_RS07540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW49_RS07560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_RS07570	COG0302	gtp cyclohydrolase
EXW49_RS07575	COG0142	geranyltranstransferase activity
EXW49_RS07580	COG2226	methyltransferase
EXW49_RS07585	COG0142	geranyltranstransferase activity
EXW49_RS07600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW49_RS07610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW49_RS07615	COG0457	Tetratricopeptide repeat
EXW49_RS07620	COG5582	Belongs to the UPF0302 family
EXW49_RS07635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW49_RS07650	COG4347	Protein of unknown function (DUF1405)
EXW49_RS07665	COG2738	Putative neutral zinc metallopeptidase
EXW49_RS07675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS07680	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW49_RS07685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW49_RS07690	COG1803	Methylglyoxal synthase
EXW49_RS07695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_RS07700	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS07705	COG0617	tRNA 3'-terminal CCA addition
EXW49_RS07715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW49_RS07720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW49_RS07730	COG1199	ATP-dependent helicase activity
EXW49_RS07730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW49_RS07750	COG3935	DnaD domain protein
EXW49_RS07755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW49_RS07765	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_RS07765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_RS07770	COG3331	DNA recombination
EXW49_RS07805	COG4474	Belongs to the UPF0398 family
EXW49_RS07810	COG3599	regulation of cell shape
EXW49_RS07820	COG0116	Belongs to the methyltransferase superfamily
EXW49_RS07830	COG1199	ATP-dependent helicase activity
EXW49_RS07835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW49_RS07845	COG0024	Methionine aminopeptidase
EXW49_RS07855	COG2233	PERMEase
EXW49_RS07860	COG2311	Membrane
EXW49_RS07870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_RS07880	COG0456	acetyltransferase
EXW49_RS07890	COG2897	thiosulfate sulfurtransferase activity
EXW49_RS07930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_RS07955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW49_RS07970	COG1215	transferase activity, transferring glycosyl groups
EXW49_RS07975	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS07990	COG0454	-acetyltransferase
EXW49_RS08010	COG0328	RNA-DNA hybrid ribonuclease activity
EXW49_RS08045	COG3403	YqcI/YcgG family
EXW49_RS08050	COG1280	lysine exporter protein (LysE YggA)
EXW49_RS08065	COG3162	membrane
EXW49_RS08070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_RS08075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_RS08085	COG0475	glutathione-regulated potassium exporter activity
EXW49_RS08090	COG4978	Transcriptional regulator
EXW49_RS08090	COG0789	Transcriptional regulator
EXW49_RS08100	COG2323	membrane
EXW49_RS08105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW49_RS08145	COG2814	Major facilitator Superfamily
EXW49_RS08165	COG1923	regulation of RNA biosynthetic process
EXW49_RS08175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW49_RS08180	COG1360	Flagellar Motor Protein
EXW49_RS08185	COG2201	protein-glutamate methylesterase activity
EXW49_RS08190	COG2198	Histidine kinase
EXW49_RS08190	COG0643	Histidine kinase
EXW49_RS08195	COG1776	CheC inhibitor of MCP methylation
EXW49_RS08195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_RS08210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW49_RS08230	COG1256	bacterial-type flagellum assembly
EXW49_RS08235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_RS08255	COG1815	bacterial-type flagellum-dependent cell motility
EXW49_RS08260	COG1558	bacterial-type flagellum-dependent cell motility
EXW49_RS08270	COG1766	The M ring may be actively involved in energy transduction
EXW49_RS08275	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_RS08285	COG1157	protein secretion by the type III secretion system
EXW49_RS08305	COG1749	Flagellar hook protein flgE
EXW49_RS08320	COG0784	Response regulator, receiver
EXW49_RS08320	COG0835	chemotaxis
EXW49_RS08340	COG0861	Integral membrane protein TerC family
EXW49_RS08350	COG3383	formate dehydrogenase (NAD+) activity
EXW49_RS08355	COG2427	Protein of unknown function (DUF1641)
EXW49_RS08360	COG5609	conserved protein (DUF2294)
EXW49_RS08365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW49_RS08375	COG2116	formate transmembrane transporter activity
EXW49_RS08380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_RS08385	COG0303	'Molybdopterin
EXW49_RS08390	COG0314	molybdopterin synthase activity
EXW49_RS08395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW49_RS08405	COG0489	protein tyrosine kinase activity
EXW49_RS08410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_RS08415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_RS08420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_RS08425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_RS08430	COG0741	lytic transglycosylase activity
EXW49_RS08440	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_RS08445	COG1776	CheC inhibitor of MCP methylation
EXW49_RS08445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_RS08455	COG1338	Plays a role in the flagellum-specific transport system
EXW49_RS08460	COG1987	bacterial-type flagellum assembly
EXW49_RS08470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW49_RS08475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW49_RS08480	COG1419	protein localization to endoplasmic reticulum
EXW49_RS08485	COG4786	Flagellar basal body rod
EXW49_RS08490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW49_RS08525	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_RS08540	COG2814	Major facilitator Superfamily
EXW49_RS08550	COG0583	DNA-binding transcription factor activity
EXW49_RS08555	COG3842	ATPase activity
EXW49_RS08605	COG0406	alpha-ribazole phosphatase activity
EXW49_RS08635	COG0367	asparagine synthase
EXW49_RS08665	COG1802	Transcriptional regulator
EXW49_RS08670	COG0697	spore germination
EXW49_RS08675	COG1216	Glycosyl transferase, family 2
EXW49_RS08675	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS08680	COG1757	Na H antiporter
EXW49_RS08685	COG0789	Transcriptional regulator
EXW49_RS08690	COG4221	oxidoreductase activity
EXW49_RS08720	COG0534	Mate efflux family protein
EXW49_RS08725	COG3340	Belongs to the peptidase S51 family
EXW49_RS08745	COG0785	Cytochrome C biogenesis protein
EXW49_RS08750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS08765	COG3048	D-serine ammonia-lyase activity
EXW49_RS08770	COG2733	membrane
EXW49_RS08805	COG1131	(ABC) transporter
EXW49_RS08825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_RS08830	COG0528	UMP kinase activity
EXW49_RS08840	COG1027	Aspartate ammonia-lyase
EXW49_RS08845	COG0281	malic enzyme
EXW49_RS08850	COG4191	Histidine kinase
EXW49_RS08855	COG0784	Response regulator, receiver
EXW49_RS08860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_RS08870	COG2502	aspartate--ammonia ligase
EXW49_RS08915	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS08925	COG2814	Major facilitator Superfamily
EXW49_RS08955	COG0477	Major facilitator Superfamily
EXW49_RS08960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_RS08970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW49_RS08975	COG2223	nitrite transmembrane transporter activity
EXW49_RS08980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_RS08995	COG2244	polysaccharide biosynthetic process
EXW49_RS09000	COG0733	neurotransmitter:sodium symporter activity
EXW49_RS09010	COG5566	PFAM Mor transcription activator
EXW49_RS09015	COG2323	membrane
EXW49_RS09035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_RS09040	COG2132	Multicopper oxidase
EXW49_RS09050	COG5002	protein histidine kinase activity
EXW49_RS09055	COG0745	RESPONSE REGULATOR receiver
EXW49_RS09065	COG0129	dihydroxy-acid dehydratase activity
EXW49_RS09070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW49_RS09095	COG2814	Major facilitator Superfamily
EXW49_RS09100	COG3384	dioxygenase
EXW49_RS09125	COG4166	transmembrane transport
EXW49_RS09130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS09140	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW49_RS09145	COG1054	Belongs to the UPF0176 family
EXW49_RS09155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW49_RS09160	COG0531	amino acid
EXW49_RS09195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_RS09210	COG4257	antibiotic catabolic process
EXW49_RS09215	COG2390	Transcriptional regulator
EXW49_RS09225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW49_RS09230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS09235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW49_RS09250	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW49_RS09270	COG0583	DNA-binding transcription factor activity
EXW49_RS09290	COG0006	proline dipeptidase activity
EXW49_RS09295	COG2132	Multicopper oxidase
EXW49_RS09305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW49_RS09315	COG0583	DNA-binding transcription factor activity
EXW49_RS09335	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS09345	COG1834	amidinotransferase
EXW49_RS09355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS09400	COG1276	copper resistance
EXW49_RS09400	COG2372	response to copper ion
EXW49_RS09405	COG4549	nuclear export factor GLE1
EXW49_RS09415	COG0697	spore germination
EXW49_RS09420	COG0583	DNA-binding transcription factor activity
EXW49_RS09425	COG1959	2 iron, 2 sulfur cluster binding
EXW49_RS09430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_RS09435	COG0778	Nitroreductase
EXW49_RS09455	COG0628	permease
EXW49_RS09475	COG0523	cobalamin synthesis protein
EXW49_RS09485	COG0411	ABC transporter
EXW49_RS09505	COG0583	DNA-binding transcription factor activity
EXW49_RS09515	COG1942	4-Oxalocrotonate Tautomerase
EXW49_RS09530	COG0346	lactoylglutathione lyase activity
EXW49_RS09540	COG1271	oxidase subunit
EXW49_RS09545	COG1294	oxidase, subunit
EXW49_RS09550	COG4988	ABC transporter
EXW49_RS09555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW49_RS09585	COG1686	Belongs to the peptidase S11 family
EXW49_RS09600	COG0791	NLP P60 protein
EXW49_RS09600	COG1388	LysM domain
EXW49_RS09610	COG1132	(ABC) transporter
EXW49_RS09615	COG0745	RESPONSE REGULATOR receiver
EXW49_RS09620	COG5002	protein histidine kinase activity
EXW49_RS09625	COG0300	oxidoreductase activity
EXW49_RS09630	COG4122	O-methyltransferase activity
EXW49_RS09645	COG5658	integral membrane protein
EXW49_RS09660	COG0460	homoserine dehydrogenase
EXW49_RS09670	COG0083	homoserine kinase activity
EXW49_RS09685	COG1316	TRANSCRIPTIONal
EXW49_RS09700	COG1285	pathogenesis
EXW49_RS09705	COG1247	-acetyltransferase
EXW49_RS09725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_RS09735	COG1082	Xylose isomerase domain protein TIM barrel
EXW49_RS09745	COG2814	Major facilitator Superfamily
EXW49_RS09750	COG1279	arginine transmembrane transporter activity
EXW49_RS09755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS09765	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW49_RS09795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW49_RS09800	COG0577	efflux transmembrane transporter activity
EXW49_RS09805	COG2002	toxin-antitoxin pair type II binding
EXW49_RS09810	COG1404	Belongs to the peptidase S8 family
EXW49_RS09815	COG0640	Transcriptional regulator
EXW49_RS09820	COG0667	Aldo Keto reductase
EXW49_RS09860	COG3949	Membrane
EXW49_RS09865	COG0783	Belongs to the Dps family
EXW49_RS09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW49_RS09890	COG1231	oxidoreductase activity
EXW49_RS09895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS09900	COG4989	oxidoreductase activity
EXW49_RS09905	COG0523	cobalamin synthesis protein
EXW49_RS09910	COG0456	acetyltransferase
EXW49_RS09915	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW49_RS09930	COG1902	pentaerythritol trinitrate reductase activity
EXW49_RS09935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW49_RS09945	COG4166	transmembrane transport
EXW49_RS09950	COG0346	lactoylglutathione lyase activity
EXW49_RS09960	COG0406	alpha-ribazole phosphatase activity
EXW49_RS09970	COG5337	Spore coat protein CotH
EXW49_RS09975	COG1051	belongs to the nudix hydrolase family
EXW49_RS09980	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS09985	COG2244	polysaccharide biosynthetic process
EXW49_RS09995	COG0701	Predicted permease
EXW49_RS10000	COG3689	TIGRFAM TIGR03943 family protein
EXW49_RS10005	COG1607	acyl-coa hydrolase
EXW49_RS10015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_RS10030	COG0702	epimerase
EXW49_RS10035	COG2839	Protein conserved in bacteria
EXW49_RS10040	COG1253	flavin adenine dinucleotide binding
EXW49_RS10065	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS10070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_RS10085	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS10095	COG1876	peptidase activity
EXW49_RS10100	COG0494	nUDIX hydrolase
EXW49_RS10105	COG0154	amidase activity
EXW49_RS10110	COG2211	Major facilitator Superfamily
EXW49_RS10125	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS10135	COG0561	phosphatase activity
EXW49_RS10140	COG1846	Transcriptional regulator
EXW49_RS10145	COG2814	Major facilitator Superfamily
EXW49_RS10155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW49_RS10160	COG4106	trans-aconitate 2-methyltransferase activity
EXW49_RS10175	COG1819	glycosyl
EXW49_RS10180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS10210	COG0456	acetyltransferase
EXW49_RS10245	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_RS10290	COG3874	Sporulation protein YtfJ
EXW49_RS10315	COG2226	methyltransferase
EXW49_RS10345	COG0604	alcohol dehydrogenase
EXW49_RS10350	COG1595	DNA-templated transcription, initiation
EXW49_RS10370	COG0426	domain, Protein
EXW49_RS10370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW49_RS10380	COG0386	Belongs to the glutathione peroxidase family
EXW49_RS10385	COG1305	Transglutaminase-like
EXW49_RS10390	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW49_RS10395	COG0714	Associated with various cellular activities
EXW49_RS10400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW49_RS10405	COG1140	nitrate reductase beta subunit
EXW49_RS10410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW49_RS10415	COG2181	nitrate reductase activity
EXW49_RS10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_RS10425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW49_RS10430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_RS10435	COG0303	'Molybdopterin
EXW49_RS10440	COG0314	molybdopterin synthase activity
EXW49_RS10450	COG2223	nitrite transmembrane transporter activity
EXW49_RS10470	COG1648	precorrin-2 dehydrogenase activity
EXW49_RS10480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW49_RS10480	COG1587	Uroporphyrinogen-III synthase
EXW49_RS10485	COG2146	nitrite reductase [NAD(P)H] activity
EXW49_RS10490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW49_RS10495	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW49_RS10525	COG2359	stage V sporulation protein S
EXW49_RS10560	COG1418	mRNA catabolic process
EXW49_RS10565	COG0488	(ABC) transporter
EXW49_RS10595	COG1413	lyase activity
EXW49_RS10610	COG2521	methyltransferase
EXW49_RS10610	COG2136	Putative SAM-dependent methyltransferase
EXW49_RS10615	COG0018	arginyl-trna synthetase
EXW49_RS10630	COG2226	methyltransferase
EXW49_RS10665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW49_RS10670	COG0017	Asparaginyl-tRNA synthetase
EXW49_RS10675	COG0733	neurotransmitter:sodium symporter activity
EXW49_RS10700	COG2610	gluconate transmembrane transporter activity
EXW49_RS10710	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_RS10720	COG0456	acetyltransferase
EXW49_RS10725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW49_RS10730	COG1131	(ABC) transporter
EXW49_RS10735	COG4473	ABC transporter
EXW49_RS10745	COG0546	phosphoglycolate phosphatase activity
EXW49_RS10795	COG0768	penicillin binding
EXW49_RS10810	COG1272	protein, Hemolysin III
EXW49_RS10820	COG0805	protein transport
EXW49_RS10830	COG1307	EDD domain protein, DegV family
EXW49_RS10835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW49_RS10840	COG1999	signal sequence binding
EXW49_RS10845	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW49_RS10850	COG0367	asparagine synthase
EXW49_RS10865	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS10870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS10875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_RS10890	COG1335	isochorismatase
EXW49_RS10900	COG0668	transmembrane transport
EXW49_RS10905	COG4585	Histidine kinase
EXW49_RS10905	COG2203	Gaf domain
EXW49_RS10910	COG2197	response regulator
EXW49_RS10915	COG1737	Transcriptional regulator
EXW49_RS10920	COG1064	alcohol dehydrogenase
EXW49_RS10940	COG1070	Carbohydrate kinase
EXW49_RS10950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW49_RS10970	COG0517	IMP dehydrogenase activity
EXW49_RS10970	COG1125	glycine betaine transport
EXW49_RS10975	COG1174	glycine betaine transport
EXW49_RS11020	COG1253	flavin adenine dinucleotide binding
EXW49_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS11030	COG5506	Protein of unknown function (DUF1694)
EXW49_RS11045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_RS11050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW49_RS11055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW49_RS11060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_RS11065	COG0456	acetyltransferase
EXW49_RS11070	COG3829	transcription factor binding
EXW49_RS11075	COG1509	lysine 2,3-aminomutase activity
EXW49_RS11085	COG4479	Belongs to the UPF0346 family
EXW49_RS11110	COG3064	Membrane
EXW49_RS11110	COG4991	sh3 domain protein
EXW49_RS11110	COG0515	serine threonine protein kinase
EXW49_RS11120	COG0671	phosphoesterase, PA-phosphatase related
EXW49_RS11125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW49_RS11130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS11180	COG2801	Transposase and inactivated derivatives
EXW49_RS11210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_RS11255	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_RS11255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_RS11265	COG2814	Major facilitator Superfamily
EXW49_RS11275	COG0372	Belongs to the citrate synthase family
EXW49_RS11280	COG2079	MmgE PrpD family protein
EXW49_RS11285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW49_RS11290	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS11295	COG2084	Dehydrogenase
EXW49_RS11300	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS11305	COG1280	lysine exporter protein (LysE YggA)
EXW49_RS11310	COG1024	Enoyl-CoA hydratase
EXW49_RS11325	COG0420	3'-5' exonuclease activity
EXW49_RS11350	COG2223	nitrite transmembrane transporter activity
EXW49_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS11360	COG1169	isochorismate synthase
EXW49_RS11365	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW49_RS11370	COG1535	isochorismatase
EXW49_RS11370	COG3433	isochorismatase activity
EXW49_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW49_RS11380	COG3251	PFAM MbtH domain protein
EXW49_RS11385	COG2814	Major facilitator Superfamily
EXW49_RS11400	COG0776	regulation of translation
EXW49_RS11410	COG2318	DinB family
EXW49_RS11415	COG1115	amino acid carrier protein
EXW49_RS11430	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_RS11440	COG1187	pseudouridine synthase activity
EXW49_RS11445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW49_RS11450	COG3655	Transcriptional regulator
EXW49_RS11460	COG1136	(ABC) transporter
EXW49_RS11485	COG0028	Belongs to the TPP enzyme family
EXW49_RS11505	COG1253	flavin adenine dinucleotide binding
EXW49_RS11535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_RS11555	COG1846	Transcriptional regulator
EXW49_RS11565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS11570	COG1309	transcriptional regulator
EXW49_RS11600	COG1247	-acetyltransferase
EXW49_RS11605	COG0583	DNA-binding transcription factor activity
EXW49_RS11610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_RS11645	COG0596	Alpha beta hydrolase
EXW49_RS11650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW49_RS11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS11690	COG0583	DNA-binding transcription factor activity
EXW49_RS11695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW49_RS11710	COG0583	DNA-binding transcription factor activity
EXW49_RS11715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW49_RS11720	COG2258	MOSC domain
EXW49_RS11735	COG1132	(ABC) transporter
EXW49_RS11740	COG1132	(ABC) transporter
EXW49_RS11760	COG1396	sequence-specific DNA binding
EXW49_RS11790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW49_RS11800	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW49_RS11805	COG1595	DNA-templated transcription, initiation
EXW49_RS11830	COG1649	PFAM Uncharacterised BCR, COG1649
EXW49_RS11850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW49_RS11855	COG2971	BadF BadG BcrA BcrD
EXW49_RS11910	COG1309	transcriptional regulator
EXW49_RS11925	COG0577	efflux transmembrane transporter activity
EXW49_RS11925	COG1136	(ABC) transporter
EXW49_RS11930	COG0500	methyltransferase
EXW49_RS11930	COG3615	Tellurite resistance protein tehB
EXW49_RS11940	COG0693	protein deglycase activity
EXW49_RS11950	COG0588	phosphoglycerate mutase activity
EXW49_RS11975	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_RS11985	COG0110	maltose O-acetyltransferase activity
EXW49_RS11990	COG1136	(ABC) transporter
EXW49_RS12020	COG1686	Belongs to the peptidase S11 family
EXW49_RS12045	COG0768	penicillin binding
EXW49_RS12050	COG0745	RESPONSE REGULATOR receiver
EXW49_RS12055	COG2205	protein histidine kinase activity
EXW49_RS12060	COG1136	(ABC) transporter
EXW49_RS12065	COG0577	efflux transmembrane transporter activity
EXW49_RS12075	COG1595	DNA-templated transcription, initiation
EXW49_RS12085	COG0768	penicillin binding
EXW49_RS12090	COG0768	penicillin binding
EXW49_RS12125	COG1252	NADH dehydrogenase
EXW49_RS12130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS12130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS12145	COG0697	spore germination
EXW49_RS12175	COG3397	chitin binding
EXW49_RS12180	COG0823	Involved in the tonB-independent uptake of proteins
EXW49_RS12190	COG1408	metallophosphoesterase
EXW49_RS12200	COG1131	(ABC) transporter
EXW49_RS12210	COG1309	transcriptional regulator
EXW49_RS12220	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS12225	COG0439	Biotin carboxylase
EXW49_RS12230	COG0511	ligase activity, forming carbon-carbon bonds
EXW49_RS12235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW49_RS12240	COG1024	Enoyl-CoA hydratase
EXW49_RS12245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW49_RS12250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_RS12295	COG0572	uridine kinase
EXW49_RS12300	COG2318	DinB family
EXW49_RS12330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_RS12385	COG1733	regulation of RNA biosynthetic process
EXW49_RS12410	COG1309	transcriptional regulator
EXW49_RS12425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_RS12440	COG0697	spore germination
EXW49_RS12445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS12475	COG2323	membrane
EXW49_RS12480	COG2132	Multicopper oxidase
EXW49_RS12495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS12500	COG0697	spore germination
EXW49_RS12505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_RS12510	COG0201	protein transport
EXW49_RS12520	COG0737	Belongs to the 5'-nucleotidase family
EXW49_RS12525	COG3227	Zinc metalloprotease (Elastase)
EXW49_RS12530	COG1523	belongs to the glycosyl hydrolase 13 family
EXW49_RS12550	COG1073	alpha beta
EXW49_RS12560	COG0577	efflux transmembrane transporter activity
EXW49_RS12565	COG1136	(ABC) transporter
EXW49_RS12595	COG5002	protein histidine kinase activity
EXW49_RS12600	COG0745	RESPONSE REGULATOR receiver
EXW49_RS12605	COG1011	Hydrolase
EXW49_RS12630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_RS12635	COG1183	phosphatidylcholine synthase activity
EXW49_RS12645	COG1132	(ABC) transporter
EXW49_RS12655	COG3961	Belongs to the TPP enzyme family
EXW49_RS12675	COG0322	excinuclease ABC activity
EXW49_RS12700	COG2318	DinB family
EXW49_RS12715	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW49_RS12740	COG3878	Protein conserved in bacteria
EXW49_RS12765	COG1051	belongs to the nudix hydrolase family
EXW49_RS12770	COG0592	DNA-directed DNA polymerase activity
EXW49_RS12775	COG2816	NAD+ diphosphatase activity
EXW49_RS12785	COG2223	nitrite transmembrane transporter activity
EXW49_RS12795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS12805	COG0494	nUDIX hydrolase
EXW49_RS12825	COG0697	spore germination
EXW49_RS12830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS12845	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_RS12860	COG1733	regulation of RNA biosynthetic process
EXW49_RS12870	COG2814	Major facilitator Superfamily
EXW49_RS12880	COG1132	(ABC) transporter
EXW49_RS12880	COG2375	cellular response to nickel ion
EXW49_RS12885	COG1132	(ABC) transporter
EXW49_RS12920	COG0768	penicillin binding
EXW49_RS12925	COG0671	phosphoesterase, PA-phosphatase related
EXW49_RS12930	COG0604	alcohol dehydrogenase
EXW49_RS12935	COG5002	protein histidine kinase activity
EXW49_RS12940	COG0745	RESPONSE REGULATOR receiver
EXW49_RS12950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_RS12960	COG2205	protein histidine kinase activity
EXW49_RS12975	COG1122	ATPase activity
EXW49_RS12980	COG4720	Psort location CytoplasmicMembrane, score
EXW49_RS12985	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_RS12990	COG1819	glycosyl
EXW49_RS13000	COG0768	penicillin binding
EXW49_RS13005	COG5002	protein histidine kinase activity
EXW49_RS13010	COG0561	phosphatase activity
EXW49_RS13055	COG2124	cytochrome p450
EXW49_RS13100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW49_RS13110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS13115	COG0460	homoserine dehydrogenase
EXW49_RS13135	COG0577	efflux transmembrane transporter activity
EXW49_RS13140	COG1136	(ABC) transporter
EXW49_RS13155	COG0488	(ABC) transporter
EXW49_RS13160	COG0667	Aldo Keto reductase
EXW49_RS13165	COG0583	DNA-binding transcription factor activity
EXW49_RS13175	COG2205	protein histidine kinase activity
EXW49_RS13180	COG0745	RESPONSE REGULATOR receiver
EXW49_RS13190	COG3773	Cell wall hydrolase
EXW49_RS13195	COG0604	alcohol dehydrogenase
EXW49_RS13230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS13245	COG2959	enzyme of heme biosynthesis
EXW49_RS13270	COG3483	tryptophan 2,3-dioxygenase activity
EXW49_RS13275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW49_RS13280	COG3844	kynureninase activity
EXW49_RS13285	COG1309	transcriptional regulator
EXW49_RS13300	COG3284	Transcriptional regulator
EXW49_RS13315	COG1349	DNA-binding transcription factor activity
EXW49_RS13335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW49_RS13340	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_RS13345	COG0022	dehydrogenase e1 component
EXW49_RS13350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_RS13360	COG2223	nitrite transmembrane transporter activity
EXW49_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS13375	COG0456	acetyltransferase
EXW49_RS13375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_RS13410	COG4176	ABC-type proline glycine betaine transport system permease component
EXW49_RS13415	COG0517	IMP dehydrogenase activity
EXW49_RS13415	COG4175	Glycine betaine
EXW49_RS13440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW49_RS13445	COG2153	protein acetylation
EXW49_RS13450	COG3397	chitin binding
EXW49_RS13460	COG1819	glycosyl
EXW49_RS13475	COG2205	protein histidine kinase activity
EXW49_RS13480	COG2315	Protein conserved in bacteria
EXW49_RS13530	COG3973	AAA domain
EXW49_RS13545	COG2105	PFAM AIG2 family protein
EXW49_RS13550	COG0514	ATP-dependent DNA helicase (RecQ)
EXW49_RS13575	COG4637	Psort location Cytoplasmic, score
EXW49_RS13595	COG1227	inorganic diphosphatase activity
EXW49_RS13600	COG3397	chitin binding
EXW49_RS13605	COG2318	DinB family
EXW49_RS13620	COG1162	GTPase activity
EXW49_RS13625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_RS13630	COG1115	amino acid carrier protein
EXW49_RS13635	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS13640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW49_RS13650	COG3938	Belongs to the proline racemase family
EXW49_RS13655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_RS13700	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS13715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW49_RS13720	COG4166	transmembrane transport
EXW49_RS13730	COG4948	Mandelate Racemase Muconate Lactonizing
EXW49_RS13750	COG0667	Aldo Keto reductase
EXW49_RS13795	COG2936	dipeptidyl-peptidase activity
EXW49_RS13805	COG0745	RESPONSE REGULATOR receiver
EXW49_RS13825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_RS13830	COG1164	Oligoendopeptidase f
EXW49_RS13850	COG1307	EDD domain protein, DegV family
EXW49_RS13875	COG1335	isochorismatase
EXW49_RS13890	COG2814	Major facilitator Superfamily
EXW49_RS13900	COG1664	Polymer-forming cytoskeletal
EXW49_RS13905	COG0789	Transcriptional regulator
EXW49_RS13910	COG4533	DNA binding
EXW49_RS13915	COG0477	Major facilitator Superfamily
EXW49_RS13915	COG2814	Major facilitator Superfamily
EXW49_RS13930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_RS13935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW49_RS13940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_RS13945	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS13950	COG3328	transposase activity
EXW49_RS13970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_RS13975	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS13980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_RS13995	COG2261	transglycosylase associated protein
EXW49_RS14010	COG2226	methyltransferase
EXW49_RS14045	COG0436	Aminotransferase
EXW49_RS14050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW49_RS14105	COG0628	permease
EXW49_RS14135	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW49_RS14145	COG0697	spore germination
EXW49_RS14170	COG4912	Dna alkylation repair
EXW49_RS14195	COG2814	Major facilitator Superfamily
EXW49_RS14200	COG1368	sulfuric ester hydrolase activity
EXW49_RS14210	COG0488	(ABC) transporter
EXW49_RS14215	COG1033	growth of symbiont in host cell
EXW49_RS14215	COG2409	Drug exporters of the RND superfamily
EXW49_RS14220	COG1309	transcriptional regulator
EXW49_RS14245	COG0287	Prephenate dehydrogenase
EXW49_RS14260	COG1605	Chorismate mutase
EXW49_RS14260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW49_RS14285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW49_RS14305	COG1388	LysM domain
EXW49_RS14305	COG3584	3D domain protein
EXW49_RS14315	COG0346	lactoylglutathione lyase activity
EXW49_RS14325	COG0431	NADPH-dependent FMN reductase
EXW49_RS14355	COG0579	oxidoreductase
EXW49_RS14365	COG2390	Transcriptional regulator
EXW49_RS14385	COG2226	methyltransferase
EXW49_RS14400	COG0346	lactoylglutathione lyase activity
EXW49_RS14405	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_RS14425	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW49_RS14430	COG2207	Transcriptional regulator
EXW49_RS14435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS14445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW49_RS14450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW49_RS14455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_RS14460	COG3239	Fatty acid desaturase
EXW49_RS14480	COG3655	Transcriptional regulator
EXW49_RS14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS14530	COG0346	lactoylglutathione lyase activity
EXW49_RS14550	COG0714	Associated with various cellular activities
EXW49_RS14570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW49_RS14575	COG0753	catalase activity
EXW49_RS14590	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW49_RS14610	COG0778	Nitroreductase
EXW49_RS14615	COG1846	Transcriptional regulator
EXW49_RS14630	COG1051	belongs to the nudix hydrolase family
EXW49_RS14635	COG3831	ATPase activity
EXW49_RS14635	COG4884	unkown
EXW49_RS14655	COG2207	Transcriptional regulator
EXW49_RS14660	COG0456	acetyltransferase
EXW49_RS14675	COG0697	spore germination
EXW49_RS14680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS14685	COG1671	Belongs to the UPF0178 family
EXW49_RS14705	COG0456	acetyltransferase
EXW49_RS14705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_RS14730	COG0730	response to heat
EXW49_RS14740	COG0833	amino acid
EXW49_RS14750	COG4335	DNA alkylation repair
EXW49_RS14775	COG0681	Belongs to the peptidase S26 family
EXW49_RS14780	COG0768	penicillin binding
EXW49_RS14790	COG3104	oligopeptide transport
EXW49_RS14795	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW49_RS14810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW49_RS14815	COG1984	allophanate hydrolase subunit 2
EXW49_RS14820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW49_RS14825	COG1414	Transcriptional regulator
EXW49_RS14855	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS14880	COG0640	Transcriptional regulator
EXW49_RS14915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW49_RS14930	COG0574	Belongs to the PEP-utilizing enzyme family
EXW49_RS14930	COG3848	Pyruvate phosphate dikinase
EXW49_RS14940	COG0572	uridine kinase
EXW49_RS14955	COG1136	(ABC) transporter
EXW49_RS14985	COG1073	alpha beta
EXW49_RS15035	COG5002	protein histidine kinase activity
EXW49_RS15040	COG0745	RESPONSE REGULATOR receiver
EXW49_RS15050	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW49_RS15065	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW49_RS15070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW49_RS15075	COG1121	(ABC) transporter
EXW49_RS15095	COG0798	PFAM Bile acid sodium symporter
EXW49_RS15100	COG0346	lactoylglutathione lyase activity
EXW49_RS15105	COG0640	Transcriptional regulator
EXW49_RS15115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_RS15115	COG3320	Male sterility
EXW49_RS15120	COG1309	transcriptional regulator
EXW49_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS15130	COG1522	sequence-specific DNA binding
EXW49_RS15145	COG0346	lactoylglutathione lyase activity
EXW49_RS15170	COG2226	methyltransferase
EXW49_RS15180	COG2814	Major facilitator Superfamily
EXW49_RS15215	COG0745	RESPONSE REGULATOR receiver
EXW49_RS15220	COG3850	Histidine kinase
EXW49_RS15220	COG5002	protein histidine kinase activity
EXW49_RS15250	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW49_RS15265	COG0673	inositol 2-dehydrogenase activity
EXW49_RS15270	COG0673	inositol 2-dehydrogenase activity
EXW49_RS15275	COG2169	Transcriptional regulator
EXW49_RS15295	COG0789	Transcriptional regulator
EXW49_RS15300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW49_RS15315	COG1136	(ABC) transporter
EXW49_RS15320	COG0577	efflux transmembrane transporter activity
EXW49_RS15340	COG3850	Histidine kinase
EXW49_RS15340	COG5002	protein histidine kinase activity
EXW49_RS15350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS15365	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_RS15390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW49_RS15445	COG2814	Major facilitator Superfamily
EXW49_RS15560	COG2801	Transposase and inactivated derivatives
EXW49_RS15635	COG0477	Major facilitator Superfamily
EXW49_RS15650	COG1846	Transcriptional regulator
EXW49_RS15655	COG2814	Major facilitator Superfamily
EXW49_RS15705	COG1476	TRANSCRIPTIONal
EXW49_RS15720	COG1288	antiporter activity
EXW49_RS15725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW49_RS15780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS15825	COG4187	Peptidase family M20/M25/M40
EXW49_RS15840	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW49_RS15845	COG2031	fatty acid transporter
EXW49_RS15855	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_RS15905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW49_RS15910	COG1288	antiporter activity
EXW49_RS15915	COG2356	endonuclease I
EXW49_RS15920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_RS15935	COG2801	Transposase and inactivated derivatives
EXW49_RS15940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW49_RS15960	COG1785	Belongs to the alkaline phosphatase family
EXW49_RS15965	COG0778	Nitroreductase
EXW49_RS15970	COG1733	regulation of RNA biosynthetic process
EXW49_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS15995	COG1131	(ABC) transporter
EXW49_RS16025	COG1595	DNA-templated transcription, initiation
EXW49_RS16040	COG1011	Hydrolase
EXW49_RS16045	COG2365	Tyrosine phosphatase family
EXW49_RS16070	COG0346	lactoylglutathione lyase activity
EXW49_RS16075	COG1940	carbohydrate kinase activity
EXW49_RS16080	COG0738	Major facilitator superfamily
EXW49_RS16085	COG0110	maltose O-acetyltransferase activity
EXW49_RS16100	COG0628	permease
EXW49_RS16105	COG2261	transglycosylase associated protein
EXW49_RS16125	COG0500	methyltransferase
EXW49_RS16135	COG0477	Major facilitator Superfamily
EXW49_RS16155	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW49_RS16165	COG1253	flavin adenine dinucleotide binding
EXW49_RS16170	COG0789	Transcriptional regulator
EXW49_RS16175	COG0697	spore germination
EXW49_RS16185	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW49_RS16190	COG3813	Protein conserved in bacteria
EXW49_RS16195	COG4702	Belongs to the UPF0303 family
EXW49_RS16205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS16225	COG0384	phenazine biosynthesis protein PhzF
EXW49_RS16245	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS16250	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_RS16255	COG1733	regulation of RNA biosynthetic process
EXW49_RS16270	COG1191	sigma factor activity
EXW49_RS16295	COG1876	peptidase activity
EXW49_RS16340	COG2197	response regulator
EXW49_RS16410	COG0657	acetylesterase activity
EXW49_RS16420	COG2814	Major facilitator Superfamily
EXW49_RS16425	COG1309	transcriptional regulator
EXW49_RS16440	COG2224	Isocitrate lyase
EXW49_RS16470	COG0814	amino acid
EXW49_RS16495	COG1151	hydroxylamine reductase activity
EXW49_RS16525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS16535	COG2072	flavoprotein involved in K transport
EXW49_RS16580	COG1695	Transcriptional regulator
EXW49_RS16585	COG0604	alcohol dehydrogenase
EXW49_RS16590	COG1113	amino acid transport
EXW49_RS16600	COG2814	Major facilitator Superfamily
EXW49_RS16610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_RS16615	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS16625	COG0534	Mate efflux family protein
EXW49_RS16630	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS16635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_RS16650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_RS16655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_RS16675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS16680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS16685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS16690	COG3739	integral membrane protein
EXW49_RS16710	COG0583	DNA-binding transcription factor activity
EXW49_RS16730	COG1193	negative regulation of DNA recombination
EXW49_RS16750	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW49_RS16755	COG1164	Oligoendopeptidase f
EXW49_RS16760	COG2957	Belongs to the agmatine deiminase family
EXW49_RS16780	COG3781	membrane
EXW49_RS16795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_RS16835	COG3973	AAA domain
EXW49_RS16845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW49_RS16850	COG0640	Transcriptional regulator
EXW49_RS16855	COG0604	alcohol dehydrogenase
EXW49_RS16860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW49_RS16865	COG0457	Tetratricopeptide repeat
EXW49_RS16875	COG2808	Putative FMN-binding domain
EXW49_RS16880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_RS16890	COG0277	FAD linked oxidase domain protein
EXW49_RS16910	COG1285	pathogenesis
EXW49_RS16920	COG2514	catechol 2,3-dioxygenase activity
EXW49_RS16925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS16930	COG1126	abc transporter atp-binding protein
EXW49_RS16935	COG0765	amino acid transport
EXW49_RS16940	COG2720	vancomycin resistance protein
EXW49_RS16965	COG1278	Cold shock
EXW49_RS16975	COG0716	FMN binding
EXW49_RS16985	COG0494	nUDIX hydrolase
EXW49_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS17015	COG0165	Argininosuccinate lyase
EXW49_RS17030	COG4145	pantothenate transmembrane transporter activity
EXW49_RS17040	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS17055	COG1657	PFAM Prenyltransferase squalene oxidase
EXW49_RS17060	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW49_RS17065	COG2962	Rard protein
EXW49_RS17070	COG3326	Membrane
EXW49_RS17100	COG2226	methyltransferase
EXW49_RS17105	COG4166	transmembrane transport
EXW49_RS17110	COG4166	transmembrane transport
EXW49_RS17115	COG4166	transmembrane transport
EXW49_RS17120	COG1316	TRANSCRIPTIONal
EXW49_RS17130	COG1595	DNA-templated transcription, initiation
EXW49_RS17140	COG1131	(ABC) transporter
EXW49_RS17160	COG0673	inositol 2-dehydrogenase activity
EXW49_RS17165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW49_RS17170	COG0187	DNA topoisomerase II activity
EXW49_RS17175	COG1832	CoA-binding protein
EXW49_RS17180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_RS17185	COG0745	RESPONSE REGULATOR receiver
EXW49_RS17195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW49_RS17195	COG1328	CTP reductase activity
EXW49_RS17205	COG4841	protein insertion into membrane
EXW49_RS17210	COG0824	Thioesterase
EXW49_RS17235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS17255	COG1132	(ABC) transporter
EXW49_RS17260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW49_RS17290	COG2211	Major facilitator Superfamily
EXW49_RS17300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW49_RS17315	COG0183	Belongs to the thiolase family
EXW49_RS17320	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS17325	COG1268	BioY protein
EXW49_RS17330	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS17335	COG1396	sequence-specific DNA binding
EXW49_RS17380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS17390	COG5002	protein histidine kinase activity
EXW49_RS17395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW49_RS17410	COG4974	Belongs to the 'phage' integrase family
EXW49_RS17425	COG0400	carboxylic ester hydrolase activity
EXW49_RS17430	COG0346	lactoylglutathione lyase activity
EXW49_RS17435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_RS17440	COG0069	glutamate synthase activity
EXW49_RS17445	COG1902	pentaerythritol trinitrate reductase activity
EXW49_RS17455	COG1329	Transcriptional regulator
EXW49_RS17460	COG0010	Belongs to the arginase family
EXW49_RS17470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW49_RS17475	COG2986	histidine ammonia-lyase
EXW49_RS17485	COG2226	methyltransferase
EXW49_RS17510	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW49_RS17515	COG0785	Cytochrome C biogenesis protein
EXW49_RS17525	COG1473	amidohydrolase
EXW49_RS17530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_RS17535	COG1131	(ABC) transporter
EXW49_RS17545	COG0583	DNA-binding transcription factor activity
EXW49_RS17555	COG1346	cytolysis
EXW49_RS17570	COG0730	response to heat
EXW49_RS17580	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS17580	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_RS17600	COG1132	(ABC) transporter
EXW49_RS17605	COG1132	(ABC) transporter
EXW49_RS17610	COG3763	UPF0154 protein
EXW49_RS17630	COG3639	organic phosphonate transmembrane transporter activity
EXW49_RS17640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS17645	COG0737	Belongs to the 5'-nucleotidase family
EXW49_RS17655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW49_RS17660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW49_RS17675	COG1695	Transcriptional regulator
EXW49_RS17680	COG0174	glutamine synthetase
EXW49_RS17685	COG0789	Transcriptional regulator
EXW49_RS17690	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW49_RS17695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW49_RS17700	COG2860	membrane
EXW49_RS17710	COG0464	growth
EXW49_RS17730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW49_RS17740	COG3584	3D domain protein
EXW49_RS17740	COG1388	LysM domain
EXW49_RS17745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW49_RS17745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW49_RS17745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_RS17750	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW49_RS17755	COG1349	DNA-binding transcription factor activity
EXW49_RS17760	COG1979	alcohol dehydrogenase
EXW49_RS17765	COG2322	membrane
EXW49_RS17775	COG1113	amino acid transport
EXW49_RS17790	COG1408	metallophosphoesterase
EXW49_RS17810	COG2217	Heavy metal translocating P-type atpase
EXW49_RS17815	COG2608	mercury ion transmembrane transporter activity
EXW49_RS17820	COG1937	Protein conserved in bacteria
EXW49_RS17840	COG2819	hydrolase of the alpha beta superfamily
EXW49_RS17845	COG1120	ATPase activity
EXW49_RS17850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS17860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS17865	COG0708	Exodeoxyribonuclease III
EXW49_RS17870	COG2169	Transcriptional regulator
EXW49_RS17875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW49_RS17880	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW49_RS17885	COG2706	6-phosphogluconolactonase activity
EXW49_RS17890	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_RS17895	COG2364	Membrane
EXW49_RS17905	COG0346	lactoylglutathione lyase activity
EXW49_RS17910	COG5001	Diguanylate cyclase
EXW49_RS17910	COG3300	MHYT domain
EXW49_RS17950	COG1346	cytolysis
EXW49_RS17960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_RS17965	COG0596	Alpha beta hydrolase
EXW49_RS17965	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_RS17970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_RS17980	COG2188	Transcriptional regulator
EXW49_RS17985	COG2723	6-phospho-beta-galactosidase activity
EXW49_RS17995	COG3773	Cell wall hydrolase
EXW49_RS18005	COG1368	sulfuric ester hydrolase activity
EXW49_RS18010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_RS18020	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW49_RS18025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW49_RS18030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW49_RS18040	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW49_RS18045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW49_RS18050	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW49_RS18055	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW49_RS18055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW49_RS18065	COG2359	stage V sporulation protein S
EXW49_RS18070	COG1692	metallophosphoesterase
EXW49_RS18075	COG1418	mRNA catabolic process
EXW49_RS18080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW49_RS18085	COG1546	Belongs to the CinA family
EXW49_RS18085	COG1058	Belongs to the CinA family
EXW49_RS18090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW49_RS18095	COG1426	Protein conserved in bacteria
EXW49_RS18110	COG0300	oxidoreductase activity
EXW49_RS18115	COG0612	Peptidase, M16
EXW49_RS18120	COG0612	Peptidase, M16
EXW49_RS18125	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW49_RS18130	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW49_RS18135	COG3845	ABC transporter
EXW49_RS18140	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW49_RS18145	COG2188	Transcriptional regulator
EXW49_RS18150	COG1674	ftsk spoiiie
EXW49_RS18160	COG0740	serine-type endopeptidase activity
EXW49_RS18165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW49_RS18175	COG0527	aspartate kinase activity
EXW49_RS18180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW49_RS18230	COG4824	toxin secretion phage lysis holin
EXW49_RS18330	COG1278	Cold shock
EXW49_RS18340	COG0582	viral genome integration into host DNA
EXW49_RS18395	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_RS18430	COG1396	sequence-specific DNA binding
EXW49_RS18455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW49_RS18460	COG1873	PFAM PRC-barrel domain
EXW49_RS18465	COG0612	Peptidase, M16
EXW49_RS18470	COG0726	polysaccharide deacetylase
EXW49_RS18475	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW49_RS18485	COG0196	riboflavin kinase activity
EXW49_RS18495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW49_RS18500	COG1550	Protein conserved in bacteria
EXW49_RS18505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW49_RS18510	COG1358	cellular component organization or biogenesis
EXW49_RS18515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW49_RS18520	COG0195	Participates in both transcription termination and antitermination
EXW49_RS18525	COG0779	Required for maturation of 30S ribosomal subunits
EXW49_RS18535	COG0442	prolyl-tRNA aminoacylation
EXW49_RS18540	COG0750	zinc metalloprotease
EXW49_RS18550	COG4589	Belongs to the CDS family
EXW49_RS18560	COG0233	cytoplasmic translational termination
EXW49_RS18565	COG0528	UMP kinase activity
EXW49_RS18570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW49_RS18575	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW49_RS18580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW49_RS18585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW49_RS18590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW49_RS18595	COG4974	Belongs to the 'phage' integrase family
EXW49_RS18600	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW49_RS18605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW49_RS18610	COG0758	DNA mediated transformation
EXW49_RS18615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW49_RS18620	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW49_RS18625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW49_RS18640	COG0335	large ribosomal subunit rRNA binding
EXW49_RS18645	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW49_RS18650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW49_RS18655	COG1837	Belongs to the UPF0109 family
EXW49_RS18665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW49_RS18670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW49_RS18675	COG0552	protein localization to endoplasmic reticulum
EXW49_RS18680	COG1196	nuclear chromosome segregation
EXW49_RS18685	COG0571	ribonuclease III activity
EXW49_RS18690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS18700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW49_RS18705	COG0416	fatty acid biosynthetic process
EXW49_RS18710	COG2050	protein possibly involved in aromatic compounds catabolism
EXW49_RS18710	COG1349	DNA-binding transcription factor activity
EXW49_RS18715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW49_RS18720	COG1461	Dihydroxyacetone kinase
EXW49_RS18725	COG1302	Protein conserved in bacteria
EXW49_RS18740	COG1564	THIamine pyrophosphokinase
EXW49_RS18745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW49_RS18755	COG2815	serine threonine protein kinase
EXW49_RS18755	COG0515	serine threonine protein kinase
EXW49_RS18760	COG0631	protein serine/threonine phosphatase activity
EXW49_RS18765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW49_RS18770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW49_RS18770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW49_RS18775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW49_RS18780	COG0242	peptide deformylase activity
EXW49_RS18785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW49_RS18790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW49_RS18795	COG1758	RNA polymerase activity
EXW49_RS18810	COG1561	YicC-like family, N-terminal region
EXW49_RS18815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW49_RS18830	COG0006	proline dipeptidase activity
EXW49_RS18900	COG0167	dihydroorotate dehydrogenase activity
EXW49_RS18905	COG0543	2 iron, 2 sulfur cluster binding
EXW49_RS18910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW49_RS18920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW49_RS18925	COG0540	Belongs to the ATCase OTCase family
EXW49_RS18935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW49_RS18940	COG0564	pseudouridine synthase activity
EXW49_RS18945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW49_RS18955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW49_RS18960	COG3599	regulation of cell shape
EXW49_RS18965	COG2302	S4 RNA-binding domain
EXW49_RS18970	COG0762	integral membrane protein
EXW49_RS18975	COG1799	cell septum assembly
EXW49_RS18980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW49_RS18990	COG1873	PFAM PRC-barrel domain
EXW49_RS18995	COG1191	sigma factor activity
EXW49_RS19000	COG1191	sigma factor activity
EXW49_RS19010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW49_RS19015	COG0849	cell division
EXW49_RS19020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW49_RS19035	COG0772	Belongs to the SEDS family
EXW49_RS19040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW49_RS19045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW49_RS19050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW49_RS19055	COG0768	penicillin binding
EXW49_RS19060	COG0768	penicillin binding
EXW49_RS19070	COG0275	rRNA processing
EXW49_RS19075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW49_RS19080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW49_RS19085	COG0454	-acetyltransferase
EXW49_RS19095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW49_RS19100	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW49_RS19105	COG1323	Belongs to the UPF0348 family
EXW49_RS19110	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW49_RS19115	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW49_RS19120	COG3314	Sporulation integral membrane protein YlbJ
EXW49_RS19125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXW49_RS19130	COG0742	ribosomal rna small subunit methyltransferase
EXW49_RS19140	COG4471	UPF0298 protein
EXW49_RS19145	COG3679	Belongs to the UPF0342 family
EXW49_RS19150	COG0406	alpha-ribazole phosphatase activity
EXW49_RS19165	COG2340	Cysteine-rich secretory protein family
EXW49_RS19175	COG3336	cytochrome c oxidase
EXW49_RS19200	COG0109	protoheme IX farnesyltransferase activity
EXW49_RS19205	COG1612	heme a metabolic process
EXW49_RS19210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW49_RS19215	COG0772	Belongs to the SEDS family
EXW49_RS19220	COG4838	Belongs to the UPF0358 family
EXW49_RS19225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW49_RS19230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW49_RS19240	COG4896	Protein conserved in bacteria
EXW49_RS19255	COG1217	gtp-binding protein TYPA
EXW49_RS19265	COG0483	inositol monophosphate 1-phosphatase activity
EXW49_RS19275	COG4493	Belongs to the UPF0637 family
EXW49_RS19280	COG4476	Belongs to the UPF0223 family
EXW49_RS19285	COG1982	Orn Lys Arg decarboxylase major
EXW49_RS19330	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_RS19335	COG0022	dehydrogenase e1 component
EXW49_RS19340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_RS19355	COG0561	phosphatase activity
EXW49_RS19360	COG5503	Protein of unknown function (DUF1447)
EXW49_RS19365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW49_RS19370	COG0569	domain protein
EXW49_RS19380	COG1473	amidohydrolase
EXW49_RS19385	COG2171	N-acyltransferase activity
EXW49_RS19390	COG0583	DNA-binding transcription factor activity
EXW49_RS19395	COG0517	IMP dehydrogenase activity
EXW49_RS19405	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW49_RS19415	COG4703	Protein of unknown function (DUF1797)
EXW49_RS19430	COG2200	EAL domain
EXW49_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS19440	COG1408	metallophosphoesterase
EXW49_RS19485	COG2814	Major facilitator Superfamily
EXW49_RS19495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW49_RS19505	COG3209	COG3209 Rhs family protein
EXW49_RS19515	COG2205	protein histidine kinase activity
EXW49_RS19525	COG0436	Aminotransferase
EXW49_RS19530	COG1609	Transcriptional regulator
EXW49_RS19535	COG3833	ABC-type maltose transport systems, permease component
EXW49_RS19540	COG1175	transmembrane transport
EXW49_RS19545	COG2182	Extracellular solute-binding protein
EXW49_RS19555	COG0366	Alpha amylase catalytic
EXW49_RS19560	COG3842	ATPase activity
EXW49_RS19605	COG0183	Belongs to the thiolase family
EXW49_RS19640	COG1695	Transcriptional regulator
EXW49_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS19655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW49_RS19660	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW49_RS19665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW49_RS19670	COG0436	Aminotransferase
EXW49_RS19675	COG1850	ribulose-bisphosphate carboxylase activity
EXW49_RS19680	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW49_RS19685	COG0235	Class ii aldolase
EXW49_RS19705	COG2084	Dehydrogenase
EXW49_RS19715	COG2199	diguanylate cyclase activity
EXW49_RS19720	COG0778	Nitroreductase
EXW49_RS19745	COG1263	PTS System
EXW49_RS19745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_RS19745	COG2190	(PTS) system
EXW49_RS19750	COG3711	transcriptional antiterminator
EXW49_RS19760	COG2188	Transcriptional regulator
EXW49_RS19765	COG0363	glucosamine-6-phosphate deaminase activity
EXW49_RS19770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW49_RS19780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW49_RS19785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW49_RS19795	COG1547	Domain of unknown function (DUF309)
EXW49_RS19805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW49_RS19810	COG4086	secreted protein
EXW49_RS19815	COG0561	phosphatase activity
EXW49_RS19820	COG0697	spore germination
EXW49_RS19835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_RS19860	COG0733	neurotransmitter:sodium symporter activity
EXW49_RS19880	COG1686	Belongs to the peptidase S11 family
EXW49_RS19885	COG1725	Transcriptional regulator
EXW49_RS19890	COG1131	(ABC) transporter
EXW49_RS19910	COG1846	Transcriptional regulator
EXW49_RS19925	COG0598	Magnesium transport protein CorA
EXW49_RS19940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW49_RS19950	COG4974	Belongs to the 'phage' integrase family
EXW49_RS19960	COG0735	belongs to the Fur family
EXW49_RS19965	COG1300	Membrane
EXW49_RS19985	COG0667	Aldo Keto reductase
EXW49_RS19990	COG0656	L-ascorbic acid biosynthetic process
EXW49_RS19995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_RS19995	COG0456	acetyltransferase
EXW49_RS20005	COG0737	Belongs to the 5'-nucleotidase family
EXW49_RS20005	COG1525	nuclease
EXW49_RS20005	COG4085	toxin activity
EXW49_RS20010	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW49_RS20020	COG0596	Alpha beta hydrolase
EXW49_RS20025	COG2056	Na+-H+ antiporter family
EXW49_RS20030	COG1609	Transcriptional regulator
EXW49_RS20035	COG0456	acetyltransferase
EXW49_RS20040	COG1073	alpha beta
EXW49_RS20055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW49_RS20055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW49_RS20060	COG0307	riboflavin synthase, alpha
EXW49_RS20065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW49_RS20065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW49_RS20080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW49_RS20085	COG4106	trans-aconitate 2-methyltransferase activity
EXW49_RS20090	COG1073	alpha beta
EXW49_RS20090	COG2226	methyltransferase
EXW49_RS20095	COG0156	8-amino-7-oxononanoate synthase activity
EXW49_RS20105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_RS20115	COG1757	Na H antiporter
EXW49_RS20120	COG0737	Belongs to the 5'-nucleotidase family
EXW49_RS20130	COG1522	sequence-specific DNA binding
EXW49_RS20155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW49_RS20165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW49_RS20175	COG0300	oxidoreductase activity
EXW49_RS20180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS20185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_RS20190	COG1760	l-serine dehydratase
EXW49_RS20195	COG1760	l-serine dehydratase
EXW49_RS20205	COG1234	tRNA 3'-trailer cleavage
EXW49_RS20220	COG1285	pathogenesis
EXW49_RS20235	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_RS20240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS20255	COG1376	ErfK ybiS ycfS ynhG family protein
EXW49_RS20260	COG4129	membrane
EXW49_RS20265	COG1126	abc transporter atp-binding protein
EXW49_RS20270	COG0765	amino acid transport
EXW49_RS20275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_RS20290	COG2816	NAD+ diphosphatase activity
EXW49_RS20295	COG2323	membrane
EXW49_RS20300	COG0772	Belongs to the SEDS family
EXW49_RS20305	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_RS20310	COG0022	dehydrogenase e1 component
EXW49_RS20315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_RS20320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW49_RS20325	COG3426	butyrate kinase activity
EXW49_RS20335	COG0280	phosphate acetyltransferase
EXW49_RS20340	COG3829	transcription factor binding
EXW49_RS20340	COG3290	protein histidine kinase activity
EXW49_RS20350	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_RS20355	COG3093	addiction module antidote protein HigA
EXW49_RS20365	COG0745	RESPONSE REGULATOR receiver
EXW49_RS20370	COG0750	zinc metalloprotease
EXW49_RS20375	COG0497	DNA recombination
EXW49_RS20380	COG1438	arginine binding
EXW49_RS20385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW49_RS20390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW49_RS20395	COG0142	geranyltranstransferase activity
EXW49_RS20400	COG1722	exodeoxyribonuclease VII activity
EXW49_RS20405	COG1570	exodeoxyribonuclease VII activity
EXW49_RS20410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW49_RS20415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW49_RS20420	COG1302	Protein conserved in bacteria
EXW49_RS20425	COG0439	Biotin carboxylase
EXW49_RS20430	COG0511	ligase activity, forming carbon-carbon bonds
EXW49_RS20475	COG3854	ATPases associated with a variety of cellular activities
EXW49_RS20495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW49_RS20500	COG0006	proline dipeptidase activity
EXW49_RS20505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW49_RS20515	COG3872	metal-dependent enzyme
EXW49_RS20525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW49_RS20530	COG1321	iron dependent repressor
EXW49_RS20565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS20575	COG1609	Transcriptional regulator
EXW49_RS20585	COG2076	Multidrug Resistance protein
EXW49_RS20590	COG2076	Multidrug Resistance protein
EXW49_RS20625	COG1725	Transcriptional regulator
EXW49_RS20640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW49_RS20645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW49_RS20650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW49_RS20655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_RS20665	COG2801	Transposase and inactivated derivatives
EXW49_RS20695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW49_RS20720	COG4970	Tfp pilus assembly protein FimT
EXW49_RS20730	COG1459	type II secretion system
EXW49_RS20735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW49_RS20790	COG0646	methionine synthase
EXW49_RS20790	COG1410	methionine synthase
EXW49_RS20795	COG0646	methionine synthase
EXW49_RS20795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW49_RS20800	COG0626	cystathionine gamma-synthase activity
EXW49_RS20805	COG0626	cystathionine gamma-synthase activity
EXW49_RS20820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS20830	COG1940	carbohydrate kinase activity
EXW49_RS20835	COG4483	Protein conserved in bacteria
EXW49_RS20840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW49_RS20845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW49_RS20850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW49_RS20855	COG0704	Plays a role in the regulation of phosphate uptake
EXW49_RS20865	COG0581	inorganic phosphate transmembrane transporter activity
EXW49_RS20870	COG0573	inorganic phosphate transmembrane transporter activity
EXW49_RS20875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW49_RS20880	COG0768	penicillin binding
EXW49_RS20885	COG0477	Major facilitator Superfamily
EXW49_RS20890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_RS20910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW49_RS20915	COG0735	belongs to the Fur family
EXW49_RS20920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW49_RS20925	COG1121	(ABC) transporter
EXW49_RS20930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS20940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW49_RS20955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW49_RS20960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW49_RS20965	COG2384	SAM-dependent methyltransferase
EXW49_RS20975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW49_RS20980	COG0358	DNA primase activity
EXW49_RS20985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW49_RS20990	COG0517	IMP dehydrogenase activity
EXW49_RS20995	COG1381	Involved in DNA repair and RecF pathway recombination
EXW49_RS21005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW49_RS21010	COG0295	cytidine deaminase activity
EXW49_RS21015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW49_RS21020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW49_RS21025	COG1480	7TM receptor with intracellular HD hydrolase
EXW49_RS21030	COG1702	phosphate starvation-inducible protein PhoH
EXW49_RS21045	COG1610	YqeY-like protein
EXW49_RS21050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW49_RS21055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW49_RS21060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW49_RS21070	COG0484	heat shock protein binding
EXW49_RS21075	COG0443	Heat shock 70 kDa protein
EXW49_RS21085	COG1420	regulation of RNA biosynthetic process
EXW49_RS21090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW49_RS21095	COG1733	regulation of RNA biosynthetic process
EXW49_RS21100	COG0481	GTPase activity
EXW49_RS21110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW49_RS21115	COG0268	Binds directly to 16S ribosomal RNA
EXW49_RS21120	COG1466	dna polymerase III delta subunit
EXW49_RS21130	COG0658	competence protein
EXW49_RS21130	COG2333	competence protein COMEC
EXW49_RS21135	COG2131	deaminase
EXW49_RS21140	COG1555	photosystem II stabilization
EXW49_RS21140	COG1596	polysaccharide export
EXW49_RS21145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_RS21150	COG2226	methyltransferase
EXW49_RS21155	COG0799	negative regulation of ribosome biogenesis
EXW49_RS21160	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW49_RS21165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW49_RS21170	COG1534	Rna-binding protein
EXW49_RS21175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW49_RS21180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW49_RS21185	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW49_RS21195	COG0688	phosphatidylethanolamine metabolic process
EXW49_RS21205	COG1595	DNA-templated transcription, initiation
EXW49_RS21210	COG2357	RelA SpoT domain protein
EXW49_RS21220	COG1785	Belongs to the alkaline phosphatase family
EXW49_RS21230	COG2267	carboxylic ester hydrolase activity
EXW49_RS21265	COG1404	Belongs to the peptidase S8 family
EXW49_RS21270	COG3186	Phenylalanine-4-hydroxylase
EXW49_RS21275	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW49_RS21280	COG2514	catechol 2,3-dioxygenase activity
EXW49_RS21285	COG2259	Doxx family
EXW49_RS21325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS21335	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_RS21335	COG1454	alcohol dehydrogenase
EXW49_RS21340	COG0626	cystathionine gamma-synthase activity
EXW49_RS21345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_RS21350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_RS21355	COG2226	methyltransferase
EXW49_RS21370	COG0768	penicillin binding
EXW49_RS21375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW49_RS21380	COG0572	uridine kinase
EXW49_RS21385	COG0826	peptidase U32
EXW49_RS21390	COG0826	peptidase U32
EXW49_RS21395	COG4122	O-methyltransferase activity
EXW49_RS21400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW49_RS21410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW49_RS21415	COG4472	Bacterial protein of unknown function (DUF965)
EXW49_RS21420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW49_RS21430	COG0628	permease
EXW49_RS21450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW49_RS21460	COG0482	sulfurtransferase activity
EXW49_RS21465	COG1104	cysteine desulfurase activity
EXW49_RS21470	COG1959	2 iron, 2 sulfur cluster binding
EXW49_RS21475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW49_RS21485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW49_RS21490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW49_RS21510	COG1490	D-aminoacyl-tRNA deacylase activity
EXW49_RS21515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW49_RS21520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW49_RS21525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW49_RS21525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW49_RS21530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW49_RS21535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW49_RS21535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW49_RS21545	COG2244	polysaccharide biosynthetic process
EXW49_RS21550	COG2323	membrane
EXW49_RS21560	COG1862	Preprotein translocase
EXW49_RS21565	COG0343	queuine tRNA-ribosyltransferase activity
EXW49_RS21580	COG2255	four-way junction helicase activity
EXW49_RS21585	COG0632	four-way junction helicase activity
EXW49_RS21590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW49_RS21600	COG2801	Transposase and inactivated derivatives
EXW49_RS21625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW49_RS21630	COG0157	Belongs to the NadC ModD family
EXW49_RS21635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW49_RS21640	COG1104	cysteine desulfurase activity
EXW49_RS21645	COG1827	regulation of RNA biosynthetic process
EXW49_RS21650	COG2258	MOSC domain
EXW49_RS21655	COG0077	Prephenate dehydratase
EXW49_RS21660	COG0577	efflux transmembrane transporter activity
EXW49_RS21665	COG0577	efflux transmembrane transporter activity
EXW49_RS21670	COG1136	(ABC) transporter
EXW49_RS21675	COG5002	protein histidine kinase activity
EXW49_RS21680	COG0745	RESPONSE REGULATOR receiver
EXW49_RS21685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW49_RS21690	COG3290	protein histidine kinase activity
EXW49_RS21700	COG2868	ribosomal protein
EXW49_RS21710	COG1530	ribonuclease E activity
EXW49_RS21715	COG1994	Peptidase M50
EXW49_RS21720	COG0739	heme binding
EXW49_RS21725	COG2894	cell division
EXW49_RS21730	COG0850	regulation of cytokinetic process
EXW49_RS21745	COG1077	Cell shape determining protein MreB Mrl
EXW49_RS21750	COG2003	Belongs to the UPF0758 family
EXW49_RS21755	COG0424	maF-like protein
EXW49_RS21765	COG0285	dihydrofolate synthase activity
EXW49_RS21780	COG1388	LysM domain
EXW49_RS21785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW49_RS21790	COG0113	porphobilinogen synthase activity
EXW49_RS21795	COG1587	Uroporphyrinogen-III synthase
EXW49_RS21800	COG0181	hydroxymethylbilane synthase activity
EXW49_RS21805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW49_RS21810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW49_RS21815	COG1846	Transcriptional regulator
EXW49_RS21820	COG1764	response to oxidative stress
EXW49_RS21825	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW49_RS21835	COG1067	ATP-dependent peptidase activity
EXW49_RS21835	COG0470	DNA polymerase III
EXW49_RS21845	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW49_RS21875	COG0622	Phosphoesterase
EXW49_RS21885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW49_RS21890	COG5401	PFAM Sporulation and spore germination
EXW49_RS21900	COG2197	response regulator
EXW49_RS21905	COG2233	PERMEase
EXW49_RS21910	COG0402	S-adenosylhomocysteine deaminase activity
EXW49_RS21915	COG1983	PspC domain protein
EXW49_RS21920	COG1396	sequence-specific DNA binding
EXW49_RS21925	COG0697	spore germination
EXW49_RS21935	COG1959	2 iron, 2 sulfur cluster binding
EXW49_RS21940	COG1668	transmembrane transport
EXW49_RS21945	COG4152	abc transporter atp-binding protein
EXW49_RS21950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW49_RS21955	COG1360	Flagellar Motor Protein
EXW49_RS21960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW49_RS21965	COG1876	peptidase activity
EXW49_RS21970	COG0824	Thioesterase
EXW49_RS21975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW49_RS21980	COG1053	succinate dehydrogenase
EXW49_RS21985	COG2009	succinate dehydrogenase
EXW49_RS21990	COG1719	4-vinyl reductase, 4VR
EXW49_RS21995	COG0322	excinuclease ABC activity
EXW49_RS22000	COG3118	belongs to the thioredoxin family
EXW49_RS22005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW49_RS22010	COG2086	electron transfer activity
EXW49_RS22015	COG1024	Enoyl-CoA hydratase
EXW49_RS22020	COG1309	transcriptional regulator
EXW49_RS22025	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS22045	COG2318	DinB family
EXW49_RS22070	COG1131	(ABC) transporter
EXW49_RS22075	COG2205	protein histidine kinase activity
EXW49_RS22080	COG0745	RESPONSE REGULATOR receiver
EXW49_RS22090	COG4895	conserved protein (DUF2196)
EXW49_RS22095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW49_RS22105	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_RS22110	COG4509	Sortase family
EXW49_RS22115	COG1120	ATPase activity
EXW49_RS22130	COG5386	Cell surface protein
EXW49_RS22140	COG5386	Cell surface protein
EXW49_RS22145	COG1114	Component of the transport system for branched-chain amino acids
EXW49_RS22155	COG1193	negative regulation of DNA recombination
EXW49_RS22160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW49_RS22160	COG1796	DNA polymerase
EXW49_RS22165	COG1286	toxin biosynthetic process
EXW49_RS22170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW49_RS22175	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW49_RS22200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW49_RS22205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW49_RS22215	COG1418	mRNA catabolic process
EXW49_RS22245	COG2814	Major facilitator Superfamily
EXW49_RS22250	COG1566	PFAM secretion protein HlyD family protein
EXW49_RS22255	COG1309	transcriptional regulator
EXW49_RS22260	COG1363	Peptidase, m42
EXW49_RS22270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW49_RS22285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW49_RS22295	COG1484	DNA-dependent DNA replication
EXW49_RS22300	COG3611	Membrane attachment protein
EXW49_RS22305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW49_RS22310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW49_RS22315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW49_RS22320	COG0237	dephospho-CoA kinase activity
EXW49_RS22325	COG1971	Probably functions as a manganese efflux pump
EXW49_RS22335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_RS22335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_RS22340	COG5002	protein histidine kinase activity
EXW49_RS22345	COG0745	RESPONSE REGULATOR receiver
EXW49_RS22360	COG0039	L-malate dehydrogenase activity
EXW49_RS22365	COG0538	isocitrate dehydrogenase activity
EXW49_RS22370	COG0372	Belongs to the citrate synthase family
EXW49_RS22380	COG0628	permease
EXW49_RS22385	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW49_RS22395	COG0205	6-phosphofructokinase activity
EXW49_RS22405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW49_RS22410	COG1725	Transcriptional regulator
EXW49_RS22415	COG0281	malic enzyme
EXW49_RS22420	COG0587	DNA-directed DNA polymerase activity
EXW49_RS22435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW49_RS22450	COG4109	DRTGG domain
EXW49_RS22460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW49_RS22465	COG0006	proline dipeptidase activity
EXW49_RS22500	COG0662	Cupin 2, conserved barrel domain protein
EXW49_RS22525	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_RS22530	COG0589	response to stress
EXW49_RS22560	COG0137	argininosuccinate synthase activity
EXW49_RS22575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS22595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW49_RS22600	COG0827	DNA restriction-modification system
EXW49_RS22605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW49_RS22610	COG3874	Sporulation protein YtfJ
EXW49_RS22630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW49_RS22640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_RS22655	COG1104	cysteine desulfurase activity
EXW49_RS22660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW49_RS22670	COG1309	transcriptional regulator
EXW49_RS22675	COG1956	GAF domain-containing protein
EXW49_RS22680	COG0626	cystathionine gamma-synthase activity
EXW49_RS22685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW49_RS22710	COG1595	DNA-templated transcription, initiation
EXW49_RS22720	COG0110	maltose O-acetyltransferase activity
EXW49_RS22725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_RS22730	COG0454	-acetyltransferase
EXW49_RS22735	COG0517	IMP dehydrogenase activity
EXW49_RS22740	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW49_RS22755	COG0745	RESPONSE REGULATOR receiver
EXW49_RS22765	COG0666	response to abiotic stimulus
EXW49_RS22775	COG1970	mechanosensitive ion channel activity
EXW49_RS22795	COG1609	Transcriptional regulator
EXW49_RS22810	COG4851	CamS sex pheromone cAM373 precursor
EXW49_RS22815	COG3118	belongs to the thioredoxin family
EXW49_RS22825	COG2309	aminopeptidase activity
EXW49_RS22845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS22850	COG1695	Transcriptional regulator
EXW49_RS22860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW49_RS22870	COG1674	ftsk spoiiie
EXW49_RS22885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_RS22890	COG4848	Belongs to the UPF0354 family
EXW49_RS22895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS22900	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW49_RS22905	COG1363	Peptidase, m42
EXW49_RS22915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS22920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW49_RS22930	COG0510	thiamine kinase activity
EXW49_RS22935	COG1523	belongs to the glycosyl hydrolase 13 family
EXW49_RS22945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_RS22950	COG1349	DNA-binding transcription factor activity
EXW49_RS22955	COG1187	pseudouridine synthase activity
EXW49_RS22960	COG2244	polysaccharide biosynthetic process
EXW49_RS22965	COG2081	HI0933 family
EXW49_RS22970	COG2814	Major facilitator Superfamily
EXW49_RS22980	COG3832	glyoxalase III activity
EXW49_RS23000	COG1329	Transcriptional regulator
EXW49_RS23025	COG0314	molybdopterin synthase activity
EXW49_RS23030	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW49_RS23035	COG0303	'Molybdopterin
EXW49_RS23040	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW49_RS23045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_RS23050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW49_RS23070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_RS23080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW49_RS23120	COG0495	leucyl-tRNA aminoacylation
EXW49_RS23125	COG2814	Major facilitator Superfamily
EXW49_RS23130	COG0475	glutathione-regulated potassium exporter activity
EXW49_RS23135	COG0490	domain, Protein
EXW49_RS23140	COG0582	viral genome integration into host DNA
EXW49_RS23150	COG1136	(ABC) transporter
EXW49_RS23165	COG1242	4 iron, 4 sulfur cluster binding
EXW49_RS23170	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW49_RS23185	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_RS23200	COG2267	carboxylic ester hydrolase activity
EXW49_RS23205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW49_RS23210	COG0671	phosphoesterase, PA-phosphatase related
EXW49_RS23215	COG0438	transferase activity, transferring glycosyl groups
EXW49_RS23220	COG0746	molybdenum cofactor guanylyltransferase activity
EXW49_RS23245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW49_RS23250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW49_RS23290	COG5002	protein histidine kinase activity
EXW49_RS23295	COG3852	Histidine kinase
EXW49_RS23300	COG0753	catalase activity
EXW49_RS23305	COG2267	carboxylic ester hydrolase activity
EXW49_RS23315	COG1368	sulfuric ester hydrolase activity
EXW49_RS23325	COG4895	conserved protein (DUF2196)
EXW49_RS23340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_RS23345	COG1116	anion transmembrane transporter activity
EXW49_RS23350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_RS23370	COG0494	nUDIX hydrolase
EXW49_RS23410	COG2076	Multidrug Resistance protein
EXW49_RS23420	COG0789	Transcriptional regulator
EXW49_RS23425	COG1854	S-ribosylhomocysteine lyase activity
EXW49_RS23435	COG0288	reversible hydration of carbon dioxide
EXW49_RS23440	COG1271	oxidase subunit
EXW49_RS23445	COG1294	oxidase, subunit
EXW49_RS23465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS23495	COG1842	Phage shock protein A
EXW49_RS23525	COG5002	protein histidine kinase activity
EXW49_RS23530	COG0745	RESPONSE REGULATOR receiver
EXW49_RS23555	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW49_RS23560	COG1597	lipid kinase activity
EXW49_RS23590	COG1136	(ABC) transporter
EXW49_RS23620	COG5002	protein histidine kinase activity
EXW49_RS23630	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS23635	COG3963	phosphatidate phosphatase activity
EXW49_RS23645	COG0577	efflux transmembrane transporter activity
EXW49_RS23650	COG1136	(ABC) transporter
EXW49_RS23655	COG3708	Transcriptional regulator
EXW49_RS23655	COG2207	Transcriptional regulator
EXW49_RS23665	COG1131	(ABC) transporter
EXW49_RS23675	COG5658	integral membrane protein
EXW49_RS23680	COG0640	Transcriptional regulator
EXW49_RS23685	COG0745	RESPONSE REGULATOR receiver
EXW49_RS23690	COG2205	protein histidine kinase activity
EXW49_RS23695	COG0577	efflux transmembrane transporter activity
EXW49_RS23700	COG0577	efflux transmembrane transporter activity
EXW49_RS23705	COG1136	(ABC) transporter
EXW49_RS23710	COG0577	efflux transmembrane transporter activity
EXW49_RS23725	COG2188	Transcriptional regulator
EXW49_RS23745	COG3964	amidohydrolase
EXW49_RS23765	COG4948	Mandelate Racemase Muconate Lactonizing
EXW49_RS23770	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_RS23775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW49_RS23780	COG0596	Alpha beta hydrolase
EXW49_RS23785	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW49_RS23790	COG1169	isochorismate synthase
EXW49_RS23795	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW49_RS23800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW49_RS23805	COG1278	Cold shock
EXW49_RS23825	COG0058	SHG alpha-glucan phosphorylase activity
EXW49_RS23835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW49_RS23840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW49_RS23845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW49_RS23865	COG2801	Transposase and inactivated derivatives
EXW49_RS24000	COG1285	pathogenesis
EXW49_RS24005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW49_RS24015	COG0166	Belongs to the GPI family
EXW49_RS24020	COG2155	Conserved Protein
EXW49_RS24025	COG1098	S1 RNA binding domain
EXW49_RS24030	COG0436	Aminotransferase
EXW49_RS24035	COG1522	sequence-specific DNA binding
EXW49_RS24040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW49_RS24045	COG2267	carboxylic ester hydrolase activity
EXW49_RS24055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW49_RS24075	COG5018	Exonuclease
EXW49_RS24080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_RS24100	COG2801	Transposase and inactivated derivatives
EXW49_RS24110	COG2050	protein possibly involved in aromatic compounds catabolism
EXW49_RS24120	COG1268	BioY protein
EXW49_RS24125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_RS24130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW49_RS24140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW49_RS24145	COG3584	3D domain protein
EXW49_RS24160	COG1252	NADH dehydrogenase
EXW49_RS24165	COG0492	ferredoxin-NADP+ reductase activity
EXW49_RS24170	COG3708	Transcriptional regulator
EXW49_RS24185	COG1683	Conserved Protein
EXW49_RS24205	COG0316	Belongs to the HesB IscA family
EXW49_RS24210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW49_RS24215	COG4844	belongs to the
EXW49_RS24220	COG1252	NADH dehydrogenase
EXW49_RS24225	COG2274	protein secretion by the type I secretion system
EXW49_RS24230	COG0390	transport system, permease component
EXW49_RS24235	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW49_RS24260	COG4837	Protein of unknown function (DUF1462)
EXW49_RS24265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW49_RS24285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_RS24290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW49_RS24325	COG1136	(ABC) transporter
EXW49_RS24345	COG1132	(ABC) transporter
EXW49_RS24395	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_RS24405	COG0647	UMP catabolic process
EXW49_RS24415	COG2445	Protein of unknown function DUF86
EXW49_RS24420	COG1494	fructose-1,6-bisphosphatase
EXW49_RS24435	COG4470	Protein conserved in bacteria
EXW49_RS24445	COG0789	Transcriptional regulator
EXW49_RS24450	COG4377	Putative membrane peptidase family (DUF2324)
EXW49_RS24470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW49_RS24475	COG0739	heme binding
EXW49_RS24485	COG3377	Domain of unknown function (DUF1805)
EXW49_RS24490	COG0737	Belongs to the 5'-nucleotidase family
EXW49_RS24495	COG2801	Transposase and inactivated derivatives
EXW49_RS24505	COG0719	Fe-S assembly protein
EXW49_RS24510	COG0822	iron-sulfur transferase activity
EXW49_RS24515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW49_RS24520	COG0719	Fe-S assembly protein
EXW49_RS24525	COG0396	ATPase activity
EXW49_RS24530	COG1464	Belongs to the NlpA lipoprotein family
EXW49_RS24535	COG1464	Belongs to the NlpA lipoprotein family
EXW49_RS24540	COG2011	ABC-type metal ion transport system permease component
EXW49_RS24555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_RS24560	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW49_RS24565	COG0509	glycine decarboxylation via glycine cleavage system
EXW49_RS24570	COG1393	Belongs to the ArsC family
EXW49_RS24605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_RS24610	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS24615	COG0183	Belongs to the thiolase family
EXW49_RS24620	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW49_RS24620	COG1024	Enoyl-CoA hydratase
EXW49_RS24630	COG1686	Belongs to the peptidase S11 family
EXW49_RS24635	COG0506	proline dehydrogenase activity
EXW49_RS24645	COG0011	TIGRFAM Protein of
EXW49_RS24650	COG0840	transmembrane signaling receptor activity
EXW49_RS24665	COG2814	Major facilitator Superfamily
EXW49_RS24670	COG0531	amino acid
EXW49_RS24695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_RS24810	COG0586	Pfam SNARE associated Golgi protein
EXW49_RS24820	COG1376	ErfK ybiS ycfS ynhG family protein
EXW49_RS24825	COG0745	RESPONSE REGULATOR receiver
EXW49_RS24830	COG5002	protein histidine kinase activity
EXW49_RS24840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_RS24850	COG0840	transmembrane signaling receptor activity
EXW49_RS24855	COG0840	transmembrane signaling receptor activity
EXW49_RS24860	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW49_RS24865	COG3227	Zinc metalloprotease (Elastase)
EXW49_RS24870	COG1741	Belongs to the pirin family
EXW49_RS24885	COG0475	glutathione-regulated potassium exporter activity
EXW49_RS24890	COG0490	domain, Protein
EXW49_RS24895	COG1115	amino acid carrier protein
EXW49_RS24900	COG0783	Belongs to the Dps family
EXW49_RS24910	COG2318	DinB family
EXW49_RS24915	COG1611	Belongs to the LOG family
EXW49_RS24925	COG1528	Iron-storage protein
EXW49_RS24930	COG2311	Membrane
EXW49_RS24935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS24940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS24945	COG1115	amino acid carrier protein
EXW49_RS24950	COG1115	amino acid carrier protein
EXW49_RS24955	COG2910	NAD(P)H-binding
EXW49_RS24980	COG0656	L-ascorbic acid biosynthetic process
EXW49_RS24985	COG2814	Major facilitator Superfamily
EXW49_RS24990	COG1733	regulation of RNA biosynthetic process
EXW49_RS25000	COG1252	NADH dehydrogenase
EXW49_RS25020	COG3290	protein histidine kinase activity
EXW49_RS25020	COG0840	transmembrane signaling receptor activity
EXW49_RS25030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW49_RS25050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_RS25065	COG1522	sequence-specific DNA binding
EXW49_RS25070	COG0288	reversible hydration of carbon dioxide
EXW49_RS25075	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW49_RS25080	COG2233	PERMEase
EXW49_RS25090	COG2801	Transposase and inactivated derivatives
EXW49_RS25130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW49_RS25135	COG0557	exoribonuclease II activity
EXW49_RS25140	COG1647	Serine aminopeptidase, S33
EXW49_RS25145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW49_RS25150	COG1346	cytolysis
EXW49_RS25165	COG0148	phosphopyruvate hydratase activity
EXW49_RS25175	COG0149	triose-phosphate isomerase activity
EXW49_RS25180	COG0126	phosphoglycerate kinase activity
EXW49_RS25185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW49_RS25200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW49_RS25235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_RS25250	COG2323	membrane
EXW49_RS25260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_RS25265	COG1481	regulation of sporulation
EXW49_RS25270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW49_RS25275	COG1660	Displays ATPase and GTPase activities
EXW49_RS25280	COG1051	belongs to the nudix hydrolase family
EXW49_RS25290	COG0492	ferredoxin-NADP+ reductase activity
EXW49_RS25295	COG0457	Tetratricopeptide repeat
EXW49_RS25300	COG0110	maltose O-acetyltransferase activity
EXW49_RS25305	COG0546	phosphoglycolate phosphatase activity
EXW49_RS25310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW49_RS25315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW49_RS25320	COG1950	PFAM Membrane protein of
EXW49_RS25325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW49_RS25345	COG0789	Transcriptional regulator
EXW49_RS25380	COG0583	DNA-binding transcription factor activity
EXW49_RS25385	COG0789	Transcriptional regulator
EXW49_RS25390	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW49_RS25395	COG0488	(ABC) transporter
EXW49_RS25405	COG1132	(ABC) transporter
EXW49_RS25410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_RS25415	COG0793	Belongs to the peptidase S41A family
EXW49_RS25415	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_RS25420	COG2177	Part of the ABC transporter FtsEX involved in
EXW49_RS25425	COG2884	Cell division ATP-binding protein ftsE
EXW49_RS25455	COG1278	Cold shock
EXW49_RS25460	COG1040	competence protein
EXW49_RS25465	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW49_RS25470	COG0791	NLP P60 protein
EXW49_RS25470	COG1388	LysM domain
EXW49_RS25475	COG1733	regulation of RNA biosynthetic process
EXW49_RS25480	COG1307	EDD domain protein, DegV family
EXW49_RS25485	COG1739	Uncharacterized protein family UPF0029
EXW49_RS25490	COG1316	TRANSCRIPTIONal
EXW49_RS25495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW49_RS25500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW49_RS25505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW49_RS25515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW49_RS25515	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW49_RS25535	COG1486	melibiose metabolic process
EXW49_RS25540	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_RS25545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_RS25550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_RS25565	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_RS25575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_RS25580	COG1301	dicarboxylic acid transport
EXW49_RS25595	COG1511	domain protein
EXW49_RS25600	COG0583	DNA-binding transcription factor activity
EXW49_RS25605	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW49_RS25615	COG1271	oxidase subunit
EXW49_RS25620	COG1294	oxidase, subunit
EXW49_RS25625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_RS25630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW49_RS25635	COG1620	l-lactate permease
EXW49_RS25645	COG2389	metal-binding protein
EXW49_RS25655	COG1368	sulfuric ester hydrolase activity
EXW49_RS25665	COG0791	NLP P60 protein
EXW49_RS25665	COG1388	LysM domain
EXW49_RS25670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_RS25680	COG1215	transferase activity, transferring glycosyl groups
EXW49_RS25685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW49_RS25690	COG1388	LysM domain
EXW49_RS25690	COG3584	3D domain protein
EXW49_RS25715	COG4715	Zinc finger, swim domain protein
EXW49_RS25720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_RS25760	COG0577	efflux transmembrane transporter activity
EXW49_RS25765	COG1136	(ABC) transporter
EXW49_RS25790	COG3850	Histidine kinase
EXW49_RS25790	COG5002	protein histidine kinase activity
EXW49_RS25795	COG0745	RESPONSE REGULATOR receiver
EXW49_RS25810	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW49_RS25825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW49_RS25840	COG0110	maltose O-acetyltransferase activity
EXW49_RS25865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EXW49_RS25870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW49_RS25875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_RS25880	COG4464	protein tyrosine phosphatase activity
EXW49_RS25885	COG0489	protein tyrosine kinase activity
EXW49_RS25890	COG3944	biosynthesis protein
EXW49_RS25895	COG0489	protein tyrosine kinase activity
EXW49_RS25910	COG1609	Transcriptional regulator
EXW49_RS25920	COG0739	heme binding
EXW49_RS25935	COG3279	Response regulator of the LytR AlgR family
EXW49_RS25940	COG2385	sporulation resulting in formation of a cellular spore
EXW49_RS25955	COG4836	Membrane
EXW49_RS25960	COG1007	ATP synthesis coupled electron transport
EXW49_RS25965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_RS25970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW49_RS25975	COG0713	ATP synthesis coupled electron transport
EXW49_RS25980	COG0839	Belongs to the complex I subunit 6 family
EXW49_RS25990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW49_RS25995	COG0649	NAD binding
EXW49_RS26000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_RS26005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_RS26010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_RS26015	COG3300	MHYT domain
EXW49_RS26015	COG5001	Diguanylate cyclase
EXW49_RS26030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW49_RS26035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW49_RS26040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW49_RS26045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW49_RS26050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW49_RS26055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW49_RS26065	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW49_RS26090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW49_RS26100	COG0698	ribose 5-phosphate isomerase
EXW49_RS26110	COG2190	(PTS) system
EXW49_RS26115	COG2259	Doxx family
EXW49_RS26120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW49_RS26130	COG1971	Probably functions as a manganese efflux pump
EXW49_RS26135	COG0009	L-threonylcarbamoyladenylate synthase
EXW49_RS26150	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW49_RS26155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW49_RS26160	COG1435	thymidine kinase activity
EXW49_RS26170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW49_RS26175	COG1494	fructose-1,6-bisphosphatase
EXW49_RS26195	COG4821	SIS domain
EXW49_RS26200	COG0504	CTP synthase activity
EXW49_RS26205	COG3343	RNA polymerase activity
EXW49_RS26215	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS26220	COG1960	acyl-CoA dehydrogenase activity
EXW49_RS26225	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW49_RS26230	COG0183	Belongs to the thiolase family
EXW49_RS26235	COG2181	nitrate reductase activity
EXW49_RS26235	COG0247	lactate metabolic process
EXW49_RS26240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_RS26245	COG4294	response to UV
EXW49_RS26250	COG3300	MHYT domain
EXW49_RS26250	COG5001	Diguanylate cyclase
EXW49_RS26265	COG3227	Zinc metalloprotease (Elastase)
EXW49_RS26270	COG2197	response regulator
EXW49_RS26275	COG4585	Histidine kinase
EXW49_RS26280	COG0842	Transport permease protein
EXW49_RS26285	COG1131	(ABC) transporter
EXW49_RS26290	COG0024	Methionine aminopeptidase
EXW49_RS26300	COG2234	aminopeptidase activity
EXW49_RS26320	COG4506	Protein conserved in bacteria
EXW49_RS26325	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_RS26340	COG0010	Belongs to the arginase family
EXW49_RS26345	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW49_RS26350	COG2814	Major facilitator Superfamily
EXW49_RS26355	COG0789	Transcriptional regulator
EXW49_RS26360	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_RS26365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_RS26375	COG1994	Peptidase M50
EXW49_RS26385	COG1078	dGTPase activity
EXW49_RS26390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_RS26395	COG1120	ATPase activity
EXW49_RS26400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS26405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_RS26410	COG4844	belongs to the
EXW49_RS26425	COG0280	phosphate acetyltransferase
EXW49_RS26430	COG3253	May function as heme-dependent peroxidase
EXW49_RS26440	COG3773	Cell wall hydrolase
EXW49_RS26450	COG2363	Small membrane protein
EXW49_RS26460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW49_RS26465	COG2233	PERMEase
EXW49_RS26470	COG0561	phosphatase activity
EXW49_RS26475	COG2814	Major facilitator Superfamily
EXW49_RS26480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW49_RS26485	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_RS26490	COG1131	(ABC) transporter
EXW49_RS26495	COG2755	lipolytic protein G-D-S-L family
EXW49_RS26500	COG1609	Transcriptional regulator
EXW49_RS26510	COG0460	homoserine dehydrogenase
EXW49_RS26515	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW49_RS26520	COG2873	o-acetylhomoserine
EXW49_RS26530	COG1011	Hydrolase
EXW49_RS26535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_RS26545	COG2197	response regulator
EXW49_RS26550	COG2203	Gaf domain
EXW49_RS26550	COG4585	Histidine kinase
EXW49_RS26555	COG0351	phosphomethylpyrimidine kinase
EXW49_RS26560	COG3706	GGDEF domain
EXW49_RS26565	COG2879	small protein
EXW49_RS26570	COG1966	Carbon starvation protein
EXW49_RS26575	COG3279	Response regulator of the LytR AlgR family
EXW49_RS26580	COG0477	Major facilitator Superfamily
EXW49_RS26605	COG0840	transmembrane signaling receptor activity
EXW49_RS26615	COG1607	acyl-coa hydrolase
EXW49_RS26620	COG1216	Glycosyl transferase, family 2
EXW49_RS26630	COG1216	Glycosyl transferase, family 2
EXW49_RS26640	COG4485	Bacterial membrane protein, YfhO
EXW49_RS26645	COG0463	Glycosyl transferase, family 2
EXW49_RS26655	COG1309	transcriptional regulator
EXW49_RS26660	COG0488	(ABC) transporter
EXW49_RS26665	COG1309	transcriptional regulator
EXW49_RS26670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW49_RS26675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_RS26675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_RS26680	COG0628	permease
EXW49_RS26690	COG1380	Effector of murein hydrolase LrgA
EXW49_RS26695	COG3279	Response regulator of the LytR AlgR family
EXW49_RS26700	COG3275	phosphorelay sensor kinase activity
EXW49_RS26705	COG2814	Major facilitator Superfamily
EXW49_RS26710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW49_RS26715	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW49_RS26720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_RS26745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW49_RS26750	COG1272	protein, Hemolysin III
EXW49_RS26775	COG1164	Oligoendopeptidase f
EXW49_RS26785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW49_RS26795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_RS26800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW49_RS26805	COG4853	Protein conserved in bacteria
EXW49_RS26815	COG5002	protein histidine kinase activity
EXW49_RS26820	COG0745	RESPONSE REGULATOR receiver
EXW49_RS26850	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_RS26855	COG0359	binds to the 23S rRNA
EXW49_RS26860	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW49_RS26865	COG4241	membrane
EXW49_RS26875	COG0629	single-stranded DNA binding
EXW49_RS26880	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW49_RS26885	COG0012	GTP binding
EXW49_RS26890	COG4481	Protein conserved in bacteria
EXW49_RS26895	COG0668	transmembrane transport
EXW49_RS26905	COG1475	DNA binding
EXW49_RS26910	COG1192	Involved in chromosome partitioning
EXW49_RS26915	COG1475	DNA binding
EXW49_RS26920	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW49_RS26925	COG0445	tRNA wobble uridine modification
EXW49_RS26930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW49_RS26935	COG1847	R3H domain protein
EXW49_RS26940	COG0706	membrane insertase activity
EXW49_RS26945	COG0594	ribonuclease P activity
EXW49_RS26950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW49_RS26955	COG1484	DNA-dependent DNA replication
EXW49_RS27010	COG0756	dUTP diphosphatase activity
EXW49_RS27065	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
EXW49_RS27100	COG5484	DNA packaging
EXW49_RS27105	COG1783	phage Terminase large subunit
EXW49_RS27110	COG5518	Phage portal protein
EXW49_RS27115	COG2369	cell adhesion
EXW49_RS27120	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW49_RS27125	COG4653	Phage capsid family
EXW49_RS27290	COG1396	sequence-specific DNA binding
EXW49_RS27305	COG1396	sequence-specific DNA binding
EXW49_RS27315	COG3646	Phage regulatory protein
EXW49_RS27345	COG0419	ATPase involved in DNA repair
EXW49_RS27380	COG0741	lytic transglycosylase activity
EXW49_RS27390	COG1674	ftsk spoiiie
EXW49_RS27405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW49_RS27430	COG5002	protein histidine kinase activity
EXW49_RS27445	COG2801	Transposase and inactivated derivatives
EXW49_RS27460	COG0024	Methionine aminopeptidase
EXW49_RS27565	COG3883	PFAM NLP P60 protein
EXW49_RS27565	COG0791	NLP P60 protein
EXW49_RS27635	COG2002	toxin-antitoxin pair type II binding
EXW49_RS27640	COG2318	DinB family
EXW49_RS27645	COG2378	regulation of single-species biofilm formation
EXW49_RS27655	COG0582	viral genome integration into host DNA
EXW49_RS27675	COG0840	transmembrane signaling receptor activity
EXW49_RS27755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_RS27795	COG2031	fatty acid transporter
EXW49_RS27820	COG0463	Glycosyl transferase, family 2
EXW49_RS27825	COG0463	Glycosyl transferase, family 2
EXW49_RS27830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW49_RS27835	COG1086	Polysaccharide biosynthesis protein
EXW49_RS27840	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW49_RS27845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_RS27850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW49_RS27865	COG2089	acid synthase
EXW49_RS27870	COG4641	Protein conserved in bacteria
EXW49_RS27905	COG0745	RESPONSE REGULATOR receiver
EXW49_RS27910	COG2205	protein histidine kinase activity
EXW49_RS27915	COG1136	(ABC) transporter
EXW49_RS27920	COG0577	efflux transmembrane transporter activity
EXW49_RS27930	COG2002	toxin-antitoxin pair type II binding
EXW49_RS27940	COG1923	regulation of RNA biosynthetic process
EXW49_RS27980	COG2814	Major facilitator Superfamily
EXW49_RS28025	COG0640	Transcriptional regulator
EXW49_RS28060	COG1733	regulation of RNA biosynthetic process
EXW49_RS28070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EXW49_RS28080	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW49_RS28080	COG2918	glutathione biosynthetic process
EXW49_RS28100	COG0583	DNA-binding transcription factor activity
EXW49_RS28155	COG4977	sequence-specific DNA binding
EXW49_RS28170	COG0083	homoserine kinase activity
EXW49_RS28185	COG1309	transcriptional regulator
EXW49_RS28190	COG2814	Major facilitator Superfamily
EXW49_RS28235	COG0814	amino acid
EXW49_RS28240	COG0697	spore germination
EXW49_RS28250	COG1760	l-serine dehydratase
EXW49_RS28255	COG1760	l-serine dehydratase
EXW49_RS28260	COG0814	amino acid
EXW49_RS28275	COG0662	Cupin 2, conserved barrel domain protein
EXW49_RS28290	COG0697	spore germination
EXW49_RS28320	COG0110	maltose O-acetyltransferase activity
EXW49_RS28335	COG1396	sequence-specific DNA binding
EXW49_RS28355	COG0840	transmembrane signaling receptor activity
EXW49_RS28360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW49_RS28400	COG4974	Belongs to the 'phage' integrase family
EXW49_RS28445	COG0697	spore germination
EXW49_RS28460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW49_RS28465	COG2239	Acts as a magnesium transporter
EXW49_RS28475	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_RS28475	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS28485	COG1725	Transcriptional regulator
EXW49_RS28490	COG1131	(ABC) transporter
EXW49_RS28545	COG1329	Transcriptional regulator
EXW49_RS28600	COG4176	ABC-type proline glycine betaine transport system permease component
EXW49_RS28605	COG0517	IMP dehydrogenase activity
EXW49_RS28605	COG4175	Glycine betaine
EXW49_RS28660	COG0582	viral genome integration into host DNA
EXW49_RS28675	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EXW49_RS28675	COG3266	domain, Protein
EXW49_RS28675	COG4932	domain protein
EXW49_RS28705	COG2801	Transposase and inactivated derivatives
EXW49_RS28770	COG0756	dUTP diphosphatase activity
EXW49_RS28795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW49_RS28795	COG2755	lipolytic protein G-D-S-L family
EXW49_RS28830	COG0745	RESPONSE REGULATOR receiver
EXW49_RS28850	COG2720	vancomycin resistance protein
EXW49_RS28905	COG0457	Tetratricopeptide repeat
EXW49_RS28965	COG1396	sequence-specific DNA binding
EXW49_RS28965	COG3800	Transcriptional regulator
EXW49_RS28985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW49_RS29070	COG0776	regulation of translation
EXW49_RS29075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW49_RS29115	COG0367	asparagine synthase
EXW49_RS29140	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_RS29160	COG0739	heme binding
EXW49_RS29245	COG0542	response to heat
EXW49_RS29255	COG3397	chitin binding
EXW49_RS29360	COG3220	belongs to the UPF0276 family
EXW49_RS29365	COG1404	Belongs to the peptidase S8 family
EXW49_RS29375	COG1132	(ABC) transporter
EXW49_RS29380	COG1404	Belongs to the peptidase S8 family
EXW49_RS29390	COG2814	Major facilitator Superfamily
EXW49_RS29395	COG2234	aminopeptidase activity
EXW49_RS29405	COG0363	glucosamine-6-phosphate deaminase activity
EXW49_RS29420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_RS29425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_RS29430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_RS29440	COG0456	acetyltransferase
EXW49_RS29625	COG0789	Transcriptional regulator
EXW49_RS29680	COG2076	Multidrug Resistance protein