locus-tag	class	description
EXW50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW50_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW50_RS00015	COG2501	S4 domain
EXW50_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW50_RS00025	COG0187	DNA topoisomerase II activity
EXW50_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW50_RS00065	COG0516	GMP reductase activity
EXW50_RS00065	COG0517	IMP dehydrogenase activity
EXW50_RS00070	COG1686	Belongs to the peptidase S11 family
EXW50_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW50_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW50_RS00100	COG1428	Deoxynucleoside kinase
EXW50_RS00105	COG1428	Deoxynucleoside kinase
EXW50_RS00110	COG1335	isochorismatase
EXW50_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW50_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW50_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW50_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW50_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW50_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW50_RS00190	COG0470	DNA polymerase III
EXW50_RS00195	COG1774	PSP1 C-terminal conserved region
EXW50_RS00200	COG4467	Involved in initiation control of chromosome replication
EXW50_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW50_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW50_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW50_RS00230	COG0084	hydrolase, TatD family'
EXW50_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW50_RS00250	COG4466	Protein conserved in bacteria
EXW50_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW50_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW50_RS00270	COG0251	oxidation-reduction process
EXW50_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW50_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW50_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW50_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW50_RS00310	COG2244	polysaccharide biosynthetic process
EXW50_RS00315	COG3956	TIGRFAM MazG family protein
EXW50_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW50_RS00340	COG1098	S1 RNA binding domain
EXW50_RS00355	COG2208	phosphoserine phosphatase activity
EXW50_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW50_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW50_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW50_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW50_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW50_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW50_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW50_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW50_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW50_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW50_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW50_RS00420	COG1396	sequence-specific DNA binding
EXW50_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW50_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW50_RS00515	COG3880	PFAM UvrB UvrC protein
EXW50_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW50_RS00525	COG0542	response to heat
EXW50_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW50_RS00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW50_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW50_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW50_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW50_RS00560	COG1045	serine acetyltransferase
EXW50_RS00565	COG0215	cysteine-tRNA ligase activity
EXW50_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW50_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW50_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW50_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW50_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW50_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW50_RS00610	COG0081	regulation of translation
EXW50_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW50_RS00620	COG0222	ribosome binding
EXW50_RS00625	COG2813	Specifically methylates the guanine in position
EXW50_RS00630	COG0085	RNA polymerase activity
EXW50_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW50_RS00640	COG1358	cellular component organization or biogenesis
EXW50_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW50_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW50_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW50_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW50_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW50_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EXW50_RS00680	COG0089	rRNA binding
EXW50_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW50_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW50_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW50_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW50_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW50_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW50_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW50_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW50_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW50_RS00760	COG1841	ribosomal large subunit assembly
EXW50_RS00765	COG0200	Binds to the 23S rRNA
EXW50_RS00770	COG0201	protein transport
EXW50_RS00775	COG0563	adenylate kinase activity
EXW50_RS00780	COG0024	Methionine aminopeptidase
EXW50_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW50_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW50_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW50_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW50_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW50_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW50_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS00855	COG0489	protein tyrosine kinase activity
EXW50_RS00865	COG2194	sulfuric ester hydrolase activity
EXW50_RS00870	COG0726	polysaccharide deacetylase
EXW50_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW50_RS00955	COG4856	YbbR-like protein
EXW50_RS00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW50_RS00975	COG4946	Tricorn protease homolog
EXW50_RS00975	COG0823	Involved in the tonB-independent uptake of proteins
EXW50_RS00975	COG1506	peptidase
EXW50_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS01005	COG2011	ABC-type metal ion transport system permease component
EXW50_RS01015	COG1464	Belongs to the NlpA lipoprotein family
EXW50_RS01030	COG0277	FAD linked oxidase domain protein
EXW50_RS01035	COG2271	Major facilitator Superfamily
EXW50_RS01045	COG2814	Major facilitator Superfamily
EXW50_RS01065	COG0601	transmembrane transport
EXW50_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW50_RS01075	COG0444	Belongs to the ABC transporter superfamily
EXW50_RS01080	COG4608	Belongs to the ABC transporter superfamily
EXW50_RS01085	COG4166	transmembrane transport
EXW50_RS01095	COG2207	Transcriptional regulator
EXW50_RS01110	COG4166	transmembrane transport
EXW50_RS01115	COG4166	transmembrane transport
EXW50_RS01120	COG0656	L-ascorbic acid biosynthetic process
EXW50_RS01125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW50_RS01140	COG4149	molybdate abc transporter
EXW50_RS01145	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW50_RS01150	COG1910	domain protein
EXW50_RS01165	COG0697	spore germination
EXW50_RS01180	COG0204	Acyl-transferase
EXW50_RS01190	COG1609	Transcriptional regulator
EXW50_RS01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS01215	COG5298	Protein conserved in bacteria
EXW50_RS01235	COG0488	(ABC) transporter
EXW50_RS01245	COG0747	negative chemotaxis
EXW50_RS01255	COG0601	transmembrane transport
EXW50_RS01260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW50_RS01265	COG0444	Belongs to the ABC transporter superfamily
EXW50_RS01270	COG4608	Belongs to the ABC transporter superfamily
EXW50_RS01275	COG0561	phosphatase activity
EXW50_RS01305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW50_RS01310	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW50_RS01320	COG0531	amino acid
EXW50_RS01325	COG2814	Major facilitator Superfamily
EXW50_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW50_RS01345	COG4294	response to UV
EXW50_RS01350	COG0705	Rhomboid family
EXW50_RS01355	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW50_RS01360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW50_RS01365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW50_RS01370	COG0864	Transcriptional regulator
EXW50_RS01375	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW50_RS01380	COG2183	response to ionizing radiation
EXW50_RS01480	COG0802	atpase or kinase
EXW50_RS01485	COG1214	PFAM Peptidase M22, glycoprotease
EXW50_RS01490	COG0456	acetyltransferase
EXW50_RS01500	COG0488	(ABC) transporter
EXW50_RS01505	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW50_RS01515	COG1266	CAAX protease self-immunity
EXW50_RS01520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW50_RS01525	COG0459	protein refolding
EXW50_RS01530	COG0519	Catalyzes the synthesis of GMP from XMP
EXW50_RS01530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW50_RS01535	COG2252	PERMEase
EXW50_RS01545	COG5002	protein histidine kinase activity
EXW50_RS01570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW50_RS01590	COG0693	protein deglycase activity
EXW50_RS01640	COG2205	protein histidine kinase activity
EXW50_RS01645	COG0745	RESPONSE REGULATOR receiver
EXW50_RS01665	COG0697	spore germination
EXW50_RS01690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW50_RS01695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW50_RS01700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW50_RS01705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW50_RS01710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW50_RS01715	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW50_RS01720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW50_RS01725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW50_RS01730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW50_RS01735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW50_RS01740	COG0138	bifunctional purine biosynthesis protein purh
EXW50_RS01745	COG0151	Belongs to the GarS family
EXW50_RS01765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW50_RS01770	COG0210	DNA helicase
EXW50_RS01775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW50_RS01780	COG4851	CamS sex pheromone cAM373 precursor
EXW50_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS01795	COG1335	isochorismatase
EXW50_RS01805	COG2011	ABC-type metal ion transport system permease component
EXW50_RS01810	COG1464	Belongs to the NlpA lipoprotein family
EXW50_RS01825	COG0003	Pfam Anion-transporting ATPase
EXW50_RS01830	COG1846	Transcriptional regulator
EXW50_RS01835	COG4682	membrane
EXW50_RS01845	COG0154	amidase activity
EXW50_RS01850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW50_RS01855	COG1597	lipid kinase activity
EXW50_RS01860	COG0546	phosphoglycolate phosphatase activity
EXW50_RS01865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW50_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS01880	COG2076	Multidrug Resistance protein
EXW50_RS01885	COG2309	aminopeptidase activity
EXW50_RS01900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS01910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW50_RS01915	COG5002	protein histidine kinase activity
EXW50_RS01920	COG4807	Protein conserved in bacteria
EXW50_RS01945	COG1757	Na H antiporter
EXW50_RS01950	COG1473	amidohydrolase
EXW50_RS01970	COG0450	alkyl hydroperoxide reductase
EXW50_RS01980	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW50_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS02005	COG0492	ferredoxin-NADP+ reductase activity
EXW50_RS02015	COG0166	Belongs to the GPI family
EXW50_RS02040	COG5002	protein histidine kinase activity
EXW50_RS02060	COG3541	Predicted nucleotidyltransferase
EXW50_RS02065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW50_RS02065	COG0723	plastoquinol--plastocyanin reductase activity
EXW50_RS02075	COG0765	amino acid transport
EXW50_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS02090	COG0840	transmembrane signaling receptor activity
EXW50_RS02115	COG0549	Belongs to the carbamate kinase family
EXW50_RS02130	COG0277	FAD linked oxidase domain protein
EXW50_RS02135	COG0366	Alpha amylase catalytic
EXW50_RS02140	COG1263	PTS System
EXW50_RS02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW50_RS02140	COG2190	(PTS) system
EXW50_RS02160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW50_RS02170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW50_RS02190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW50_RS02195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW50_RS02200	COG1116	anion transmembrane transporter activity
EXW50_RS02205	COG0488	(ABC) transporter
EXW50_RS02250	COG2270	Major facilitator Superfamily
EXW50_RS02280	COG2310	stress, protein
EXW50_RS02285	COG2310	stress, protein
EXW50_RS02290	COG2310	stress, protein
EXW50_RS02295	COG0861	Integral membrane protein TerC family
EXW50_RS02305	COG3853	Toxic anion resistance protein (TelA)
EXW50_RS02315	COG4840	Belongs to the UPF0435 family
EXW50_RS02320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW50_RS02330	COG1295	ribonuclease BN
EXW50_RS02335	COG2217	Heavy metal translocating P-type atpase
EXW50_RS02340	COG0697	spore germination
EXW50_RS02360	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS02375	COG3871	stress protein (general stress protein 26)
EXW50_RS02380	COG0387	Pfam Sodium calcium exchanger
EXW50_RS02390	COG0535	radical SAM domain protein
EXW50_RS02410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW50_RS02430	COG3829	transcription factor binding
EXW50_RS02440	COG0833	amino acid
EXW50_RS02445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW50_RS02465	COG2066	Belongs to the glutaminase family
EXW50_RS02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW50_RS02470	COG1263	PTS System
EXW50_RS02475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW50_RS02490	COG1216	Glycosyl transferase, family 2
EXW50_RS02500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW50_RS02500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW50_RS02505	COG0463	Glycosyl transferase, family 2
EXW50_RS02520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW50_RS02525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW50_RS02540	COG1228	amidohydrolase
EXW50_RS02545	COG1090	epimerase
EXW50_RS02550	COG2137	regulation of response to DNA damage stimulus
EXW50_RS02575	COG1988	membrane-bound metal-dependent
EXW50_RS02580	COG1194	a g-specific adenine glycosylase
EXW50_RS02600	COG3557	Belongs to the UPF0374 family
EXW50_RS02605	COG1132	(ABC) transporter
EXW50_RS02610	COG4129	membrane
EXW50_RS02615	COG0070	glutamate synthase
EXW50_RS02615	COG0067	glutamate synthase
EXW50_RS02615	COG0069	glutamate synthase activity
EXW50_RS02620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW50_RS02625	COG4555	ABC transporter
EXW50_RS02645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW50_RS02650	COG0735	belongs to the Fur family
EXW50_RS02770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW50_RS02775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW50_RS02795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW50_RS02805	COG2766	serine protein kinase
EXW50_RS02810	COG2718	Belongs to the UPF0229 family
EXW50_RS02825	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW50_RS02830	COG2268	Band 7 protein
EXW50_RS02840	COG3290	protein histidine kinase activity
EXW50_RS02845	COG4565	transcriptional regulatory protein
EXW50_RS02850	COG2851	Citrate transporter
EXW50_RS02875	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW50_RS02880	COG3842	ATPase activity
EXW50_RS02885	COG1175	transmembrane transport
EXW50_RS02890	COG0395	ABC-type sugar transport system, permease component
EXW50_RS02900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW50_RS02905	COG0745	RESPONSE REGULATOR receiver
EXW50_RS02910	COG5002	protein histidine kinase activity
EXW50_RS02920	COG4990	cell redox homeostasis
EXW50_RS02930	COG3290	protein histidine kinase activity
EXW50_RS02935	COG4565	transcriptional regulatory protein
EXW50_RS02940	COG3493	citrate carrier protein
EXW50_RS02945	COG0281	malic enzyme
EXW50_RS02955	COG0697	spore germination
EXW50_RS02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS02970	COG5002	protein histidine kinase activity
EXW50_RS02975	COG0745	RESPONSE REGULATOR receiver
EXW50_RS02980	COG0456	acetyltransferase
EXW50_RS02985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW50_RS02990	COG3383	formate dehydrogenase (NAD+) activity
EXW50_RS02995	COG2427	Protein of unknown function (DUF1641)
EXW50_RS03010	COG0531	amino acid
EXW50_RS03020	COG0640	Transcriptional regulator
EXW50_RS03025	COG2217	Heavy metal translocating P-type atpase
EXW50_RS03030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW50_RS03045	COG3227	Zinc metalloprotease (Elastase)
EXW50_RS03065	COG2720	vancomycin resistance protein
EXW50_RS03070	COG1316	TRANSCRIPTIONal
EXW50_RS03075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS03080	COG0346	lactoylglutathione lyase activity
EXW50_RS03085	COG1253	flavin adenine dinucleotide binding
EXW50_RS03090	COG1027	Aspartate ammonia-lyase
EXW50_RS03095	COG1620	l-lactate permease
EXW50_RS03100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS03115	COG3104	oligopeptide transport
EXW50_RS03120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS03145	COG0156	8-amino-7-oxononanoate synthase activity
EXW50_RS03150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW50_RS03160	COG4548	von Willebrand factor, type A
EXW50_RS03165	COG0714	Associated with various cellular activities
EXW50_RS03185	COG0531	amino acid
EXW50_RS03190	COG2188	Transcriptional regulator
EXW50_RS03195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW50_RS03195	COG1263	PTS System
EXW50_RS03200	COG0366	Alpha amylase catalytic
EXW50_RS03215	COG0697	spore germination
EXW50_RS03225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW50_RS03230	COG1115	amino acid carrier protein
EXW50_RS03235	COG1126	abc transporter atp-binding protein
EXW50_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS03245	COG0765	amino acid transport
EXW50_RS03250	COG0765	amino acid transport
EXW50_RS03255	COG0833	amino acid
EXW50_RS03280	COG2378	regulation of single-species biofilm formation
EXW50_RS03285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW50_RS03290	COG5002	protein histidine kinase activity
EXW50_RS03305	COG0659	secondary active sulfate transmembrane transporter activity
EXW50_RS03330	COG0601	transmembrane transport
EXW50_RS03335	COG4608	Belongs to the ABC transporter superfamily
EXW50_RS03345	COG2271	Major facilitator Superfamily
EXW50_RS03350	COG1846	Transcriptional regulator
EXW50_RS03355	COG0477	Major facilitator Superfamily
EXW50_RS03360	COG1609	Transcriptional regulator
EXW50_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW50_RS03370	COG1869	D-ribose catabolic process
EXW50_RS03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW50_RS03385	COG1879	ABC-type sugar transport system periplasmic component
EXW50_RS03415	COG1063	alcohol dehydrogenase
EXW50_RS03460	COG0840	transmembrane signaling receptor activity
EXW50_RS03465	COG3583	domain protein
EXW50_RS03465	COG3584	3D domain protein
EXW50_RS03470	COG1476	TRANSCRIPTIONal
EXW50_RS03490	COG3104	oligopeptide transport
EXW50_RS03495	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS03510	COG1113	amino acid transport
EXW50_RS03515	COG2252	PERMEase
EXW50_RS03520	COG3620	sequence-specific DNA binding
EXW50_RS03540	COG0475	glutathione-regulated potassium exporter activity
EXW50_RS03540	COG0569	domain protein
EXW50_RS03550	COG1845	cytochrome c oxidase, subunit III
EXW50_RS03555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW50_RS03565	COG0833	amino acid
EXW50_RS03570	COG4990	cell redox homeostasis
EXW50_RS03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW50_RS03590	COG0697	spore germination
EXW50_RS03595	COG0531	amino acid
EXW50_RS03605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW50_RS03610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW50_RS03620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW50_RS03625	COG0573	inorganic phosphate transmembrane transporter activity
EXW50_RS03630	COG0581	inorganic phosphate transmembrane transporter activity
EXW50_RS03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW50_RS03760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW50_RS03775	COG3103	Sh3 type 3 domain protein
EXW50_RS03775	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS03775	COG4991	sh3 domain protein
EXW50_RS03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW50_RS03785	COG1116	anion transmembrane transporter activity
EXW50_RS03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW50_RS03795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW50_RS03800	COG0352	thiamine-phosphate diphosphorylase activity
EXW50_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW50_RS03810	COG2104	thiamine diphosphate biosynthetic process
EXW50_RS03815	COG2022	thiamine diphosphate biosynthetic process
EXW50_RS03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW50_RS03825	COG0351	phosphomethylpyrimidine kinase
EXW50_RS03845	COG1136	(ABC) transporter
EXW50_RS03875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW50_RS03880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW50_RS03885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW50_RS03890	COG2205	protein histidine kinase activity
EXW50_RS03895	COG2814	Major facilitator Superfamily
EXW50_RS03900	COG1846	Transcriptional regulator
EXW50_RS03920	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW50_RS03925	COG1129	ABC transporter
EXW50_RS03930	COG1879	ABC-type sugar transport system periplasmic component
EXW50_RS03935	COG2252	PERMEase
EXW50_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS04000	COG0778	Nitroreductase
EXW50_RS04005	COG2719	SpoVR family
EXW50_RS04030	COG1937	Protein conserved in bacteria
EXW50_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
EXW50_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS04040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS04045	COG0425	Belongs to the sulfur carrier protein TusA family
EXW50_RS04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS04050	COG0425	Belongs to the sulfur carrier protein TusA family
EXW50_RS04055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS04060	COG2210	Belongs to the sulfur carrier protein TusA family
EXW50_RS04065	COG0730	response to heat
EXW50_RS04075	COG1316	TRANSCRIPTIONal
EXW50_RS04095	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW50_RS04100	COG0604	alcohol dehydrogenase
EXW50_RS04105	COG2814	Major facilitator Superfamily
EXW50_RS04115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW50_RS04115	COG3711	transcriptional antiterminator
EXW50_RS04120	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW50_RS04125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW50_RS04150	COG3584	3D domain protein
EXW50_RS04150	COG1388	LysM domain
EXW50_RS04155	COG0577	efflux transmembrane transporter activity
EXW50_RS04160	COG1136	(ABC) transporter
EXW50_RS04170	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW50_RS04185	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS04190	COG3546	catalase activity
EXW50_RS04220	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS04250	COG0531	amino acid
EXW50_RS04255	COG0475	glutathione-regulated potassium exporter activity
EXW50_RS04265	COG1737	Transcriptional regulator
EXW50_RS04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW50_RS04275	COG1263	PTS System
EXW50_RS04285	COG2259	Doxx family
EXW50_RS04310	COG1522	sequence-specific DNA binding
EXW50_RS04335	COG2076	Multidrug Resistance protein
EXW50_RS04340	COG1309	transcriptional regulator
EXW50_RS04345	COG2814	Major facilitator Superfamily
EXW50_RS04350	COG1733	regulation of RNA biosynthetic process
EXW50_RS04365	COG4533	DNA binding
EXW50_RS04370	COG2211	Major facilitator Superfamily
EXW50_RS04390	COG0531	amino acid
EXW50_RS04395	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS04400	COG1132	(ABC) transporter
EXW50_RS04405	COG1132	(ABC) transporter
EXW50_RS04410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS04415	COG0765	amino acid transport
EXW50_RS04420	COG1126	abc transporter atp-binding protein
EXW50_RS04435	COG0189	ligase activity
EXW50_RS04445	COG4399	Belongs to the UPF0754 family
EXW50_RS04450	COG3679	Belongs to the UPF0342 family
EXW50_RS04465	COG0028	Belongs to the TPP enzyme family
EXW50_RS04470	COG3527	Alpha-acetolactate decarboxylase
EXW50_RS04475	COG0463	Glycosyl transferase, family 2
EXW50_RS04480	COG1216	Glycosyl transferase, family 2
EXW50_RS04485	COG2094	Belongs to the DNA glycosylase MPG family
EXW50_RS04490	COG0561	phosphatase activity
EXW50_RS04500	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS04500	COG3409	Peptidoglycan-binding domain 1 protein
EXW50_RS04505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW50_RS04510	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS04520	COG0659	secondary active sulfate transmembrane transporter activity
EXW50_RS04525	COG2244	polysaccharide biosynthetic process
EXW50_RS04545	COG1024	Enoyl-CoA hydratase
EXW50_RS04565	COG1363	Peptidase, m42
EXW50_RS04580	COG2318	DinB family
EXW50_RS04600	COG0579	oxidoreductase
EXW50_RS04645	COG0601	transmembrane transport
EXW50_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW50_RS04655	COG0444	Belongs to the ABC transporter superfamily
EXW50_RS04660	COG4608	Belongs to the ABC transporter superfamily
EXW50_RS04685	COG0477	Major facilitator Superfamily
EXW50_RS04690	COG3290	protein histidine kinase activity
EXW50_RS04695	COG4565	transcriptional regulatory protein
EXW50_RS04700	COG3181	Tripartite tricarboxylate transporter family receptor
EXW50_RS04740	COG4978	Transcriptional regulator
EXW50_RS04740	COG0789	Transcriptional regulator
EXW50_RS04755	COG0305	Participates in initiation and elongation during chromosome replication
EXW50_RS04785	COG1842	Phage shock protein A
EXW50_RS04800	COG0477	Major facilitator Superfamily
EXW50_RS04850	COG2814	Major facilitator Superfamily
EXW50_RS04855	COG0640	Transcriptional regulator
EXW50_RS04875	COG2376	Dihydroxyacetone kinase
EXW50_RS04890	COG2376	Dihydroxyacetone kinase
EXW50_RS04905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW50_RS04910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW50_RS04950	COG1959	2 iron, 2 sulfur cluster binding
EXW50_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW50_RS04985	COG0457	Tetratricopeptide repeat
EXW50_RS04995	COG2373	Large extracellular alpha-helical protein
EXW50_RS05050	COG0825	malonyl-CoA metabolic process
EXW50_RS05075	COG2807	transmembrane transport
EXW50_RS05080	COG2186	Transcriptional regulator
EXW50_RS05090	COG4585	Histidine kinase
EXW50_RS05095	COG2197	response regulator
EXW50_RS05125	COG0420	3'-5' exonuclease activity
EXW50_RS05130	COG4717	serine-type aminopeptidase activity
EXW50_RS05135	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW50_RS05145	COG0346	lactoylglutathione lyase activity
EXW50_RS05150	COG0346	lactoylglutathione lyase activity
EXW50_RS05155	COG0457	Tetratricopeptide repeat
EXW50_RS05165	COG2267	carboxylic ester hydrolase activity
EXW50_RS05175	COG3620	sequence-specific DNA binding
EXW50_RS05180	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW50_RS05185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW50_RS05190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW50_RS05195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW50_RS05200	COG1695	Transcriptional regulator
EXW50_RS05220	COG1595	DNA-templated transcription, initiation
EXW50_RS05235	COG3973	AAA domain
EXW50_RS05240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW50_RS05265	COG0537	adenosine 5'-monophosphoramidase activity
EXW50_RS05270	COG1131	(ABC) transporter
EXW50_RS05275	COG4473	ABC transporter
EXW50_RS05285	COG0247	lactate metabolic process
EXW50_RS05290	COG1139	Iron-sulfur cluster binding protein
EXW50_RS05295	COG1556	Lactate utilization protein
EXW50_RS05315	COG3402	PFAM membrane-flanked domain
EXW50_RS05320	COG3428	Bacterial PH domain
EXW50_RS05360	COG3402	PFAM membrane-flanked domain
EXW50_RS05365	COG3428	Bacterial PH domain
EXW50_RS05370	COG2329	Antibiotic biosynthesis monooxygenase
EXW50_RS05375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW50_RS05380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW50_RS05385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW50_RS05390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW50_RS05410	COG1309	transcriptional regulator
EXW50_RS05415	COG1511	domain protein
EXW50_RS05450	COG1609	Transcriptional regulator
EXW50_RS05460	COG1234	tRNA 3'-trailer cleavage
EXW50_RS05465	COG0095	Lipoate-protein ligase
EXW50_RS05475	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS05490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW50_RS05500	COG4208	sulfate ABC transporter
EXW50_RS05515	COG1408	metallophosphoesterase
EXW50_RS05520	COG1078	dGTPase activity
EXW50_RS05535	COG1595	DNA-templated transcription, initiation
EXW50_RS05540	COG3708	Transcriptional regulator
EXW50_RS05540	COG2207	Transcriptional regulator
EXW50_RS05545	COG2205	protein histidine kinase activity
EXW50_RS05550	COG0745	RESPONSE REGULATOR receiver
EXW50_RS05570	COG0501	Belongs to the peptidase M48B family
EXW50_RS05575	COG0840	transmembrane signaling receptor activity
EXW50_RS05580	COG0697	spore germination
EXW50_RS05585	COG3693	PFAM glycoside hydrolase, family 10
EXW50_RS05590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW50_RS05595	COG2224	Isocitrate lyase
EXW50_RS05605	COG1278	Cold shock
EXW50_RS05620	COG4903	ComK protein
EXW50_RS05625	COG0398	Pfam SNARE associated Golgi protein
EXW50_RS05635	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW50_RS05640	COG1074	ATP-dependent DNA helicase activity
EXW50_RS05690	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW50_RS05715	COG0367	asparagine synthase
EXW50_RS05730	COG0753	catalase activity
EXW50_RS05735	COG0004	ammonium transporteR
EXW50_RS05745	COG1666	GTP binding
EXW50_RS05750	COG2996	Protein conserved in bacteria
EXW50_RS05765	COG1329	Transcriptional regulator
EXW50_RS05795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW50_RS05805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS05820	COG0561	phosphatase activity
EXW50_RS05840	COG2267	carboxylic ester hydrolase activity
EXW50_RS05855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS05860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW50_RS05865	COG5504	Zn-dependent protease
EXW50_RS05875	COG0180	Tryptophanyl-tRNA synthetase
EXW50_RS05885	COG4166	transmembrane transport
EXW50_RS05890	COG0601	transmembrane transport
EXW50_RS05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW50_RS05900	COG0444	Belongs to the ABC transporter superfamily
EXW50_RS05905	COG4608	Belongs to the ABC transporter superfamily
EXW50_RS05910	COG0534	Mate efflux family protein
EXW50_RS05915	COG4166	transmembrane transport
EXW50_RS05930	COG0861	Integral membrane protein TerC family
EXW50_RS05935	COG4862	establishment of competence for transformation
EXW50_RS05940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW50_RS05950	COG1164	Oligoendopeptidase f
EXW50_RS05960	COG2346	COG2346, Truncated hemoglobins
EXW50_RS05965	COG4116	CYTH
EXW50_RS05975	COG2357	RelA SpoT domain protein
EXW50_RS05985	COG0564	pseudouridine synthase activity
EXW50_RS05995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW50_RS06000	COG0772	Belongs to the SEDS family
EXW50_RS06005	COG1216	Glycosyl transferase, family 2
EXW50_RS06025	COG0463	Glycosyl transferase, family 2
EXW50_RS06025	COG0457	Tetratricopeptide repeat
EXW50_RS06045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW50_RS06060	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW50_RS06105	COG2153	protein acetylation
EXW50_RS06110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW50_RS06115	COG2382	esterase
EXW50_RS06140	COG5492	domain, Protein
EXW50_RS06145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW50_RS06155	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW50_RS06155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW50_RS06160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW50_RS06165	COG0134	indole-3-glycerol-phosphate synthase activity
EXW50_RS06170	COG0135	phosphoribosylanthranilate isomerase activity
EXW50_RS06175	COG0133	tryptophan synthase activity
EXW50_RS06180	COG0159	tryptophan synthase activity
EXW50_RS06190	COG1620	l-lactate permease
EXW50_RS06195	COG5634	Uncharacterized conserved protein (DUF2278)
EXW50_RS06245	COG2226	methyltransferase
EXW50_RS06265	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW50_RS06270	COG0567	Dehydrogenase, E1 component
EXW50_RS06275	COG1476	TRANSCRIPTIONal
EXW50_RS06300	COG4152	abc transporter atp-binding protein
EXW50_RS06305	COG1668	transmembrane transport
EXW50_RS06355	COG0582	viral genome integration into host DNA
EXW50_RS06395	COG1686	Belongs to the peptidase S11 family
EXW50_RS06400	COG0681	Belongs to the peptidase S26 family
EXW50_RS06435	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS06445	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW50_RS06450	COG1177	transmembrane transport
EXW50_RS06455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW50_RS06465	COG2409	Drug exporters of the RND superfamily
EXW50_RS06475	COG0564	pseudouridine synthase activity
EXW50_RS06485	COG2340	Cysteine-rich secretory protein family
EXW50_RS06490	COG0247	lactate metabolic process
EXW50_RS06495	COG0277	FAD linked oxidase domain protein
EXW50_RS06500	COG3835	regulator
EXW50_RS06510	COG0745	RESPONSE REGULATOR receiver
EXW50_RS06515	COG5002	protein histidine kinase activity
EXW50_RS06520	COG2186	Transcriptional regulator
EXW50_RS06525	COG0247	lactate metabolic process
EXW50_RS06530	COG1139	Iron-sulfur cluster binding protein
EXW50_RS06535	COG1556	Lactate utilization protein
EXW50_RS06540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW50_RS06550	COG2116	formate transmembrane transporter activity
EXW50_RS06555	COG0861	Integral membrane protein TerC family
EXW50_RS06560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW50_RS06570	COG2030	dehydratase
EXW50_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS06595	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW50_RS06605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW50_RS06620	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW50_RS06625	COG3842	ATPase activity
EXW50_RS06640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW50_RS06650	COG1349	DNA-binding transcription factor activity
EXW50_RS06660	COG0235	Class ii aldolase
EXW50_RS06670	COG2861	carbohydrate metabolic process
EXW50_RS06680	COG3852	Histidine kinase
EXW50_RS06685	COG1846	Transcriptional regulator
EXW50_RS06695	COG2318	DinB family
EXW50_RS06700	COG5002	protein histidine kinase activity
EXW50_RS06705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW50_RS06710	COG0720	synthase
EXW50_RS06720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW50_RS06725	COG4873	Protein conserved in bacteria
EXW50_RS06740	COG0456	acetyltransferase
EXW50_RS06755	COG1780	Probably involved in ribonucleotide reductase function
EXW50_RS06770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW50_RS06775	COG0531	amino acid
EXW50_RS06780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW50_RS06795	COG2204	response regulator
EXW50_RS06800	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS06810	COG1725	Transcriptional regulator
EXW50_RS06815	COG1131	(ABC) transporter
EXW50_RS06825	COG1131	(ABC) transporter
EXW50_RS06830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW50_RS06835	COG1266	CAAX protease self-immunity
EXW50_RS06845	COG1522	sequence-specific DNA binding
EXW50_RS06855	COG1335	isochorismatase
EXW50_RS06865	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW50_RS06870	COG2070	2-Nitropropane dioxygenase
EXW50_RS06875	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW50_RS06880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW50_RS06885	COG1696	Membrane protein involved in D-alanine export
EXW50_RS06890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW50_RS06910	COG0716	FMN binding
EXW50_RS06945	COG0534	Mate efflux family protein
EXW50_RS06970	COG1846	Transcriptional regulator
EXW50_RS06980	COG1301	dicarboxylic acid transport
EXW50_RS06985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW50_RS06995	COG3874	Sporulation protein YtfJ
EXW50_RS07015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW50_RS07020	COG0028	Belongs to the TPP enzyme family
EXW50_RS07025	COG0440	acetolactate synthase activity
EXW50_RS07035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW50_RS07045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW50_RS07055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW50_RS07060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW50_RS07070	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW50_RS07075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW50_RS07080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW50_RS07085	COG0107	imidazoleglycerol-phosphate synthase activity
EXW50_RS07095	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW50_RS07100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW50_RS07115	COG1183	phosphatidylcholine synthase activity
EXW50_RS07120	COG1368	sulfuric ester hydrolase activity
EXW50_RS07130	COG0019	diaminopimelate decarboxylase activity
EXW50_RS07140	COG0175	sulfate reduction
EXW50_RS07145	COG2046	Belongs to the sulfate adenylyltransferase family
EXW50_RS07150	COG0529	Catalyzes the synthesis of activated sulfate
EXW50_RS07155	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW50_RS07175	COG1648	precorrin-2 dehydrogenase activity
EXW50_RS07180	COG0733	neurotransmitter:sodium symporter activity
EXW50_RS07205	COG1757	Na H antiporter
EXW50_RS07225	COG4758	membrane
EXW50_RS07230	COG4585	Histidine kinase
EXW50_RS07235	COG2197	response regulator
EXW50_RS07245	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW50_RS07295	COG0730	response to heat
EXW50_RS07300	COG0306	phosphate transporter
EXW50_RS07305	COG1392	Phosphate transport regulator
EXW50_RS07310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW50_RS07325	COG3852	Histidine kinase
EXW50_RS07330	COG1801	Protein of unknown function DUF72
EXW50_RS07340	COG0582	viral genome integration into host DNA
EXW50_RS07345	COG5002	protein histidine kinase activity
EXW50_RS07360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW50_RS07360	COG0392	lysyltransferase activity
EXW50_RS07375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW50_RS07380	COG1686	Belongs to the peptidase S11 family
EXW50_RS07385	COG2715	membrane protein required for spore maturation
EXW50_RS07390	COG0700	Nucleoside recognition
EXW50_RS07395	COG1187	pseudouridine synthase activity
EXW50_RS07405	COG1333	cytochrome c biogenesis protein
EXW50_RS07410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW50_RS07415	COG0745	RESPONSE REGULATOR receiver
EXW50_RS07420	COG5002	protein histidine kinase activity
EXW50_RS07425	COG2096	Adenosyltransferase
EXW50_RS07430	COG4942	peptidase
EXW50_RS07440	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW50_RS07445	COG1141	Ferredoxin
EXW50_RS07450	COG4955	Helix-turn-helix domain
EXW50_RS07455	COG0514	ATP-dependent DNA helicase (RecQ)
EXW50_RS07460	COG1266	CAAX protease self-immunity
EXW50_RS07470	COG1408	metallophosphoesterase
EXW50_RS07485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW50_RS07505	COG0492	ferredoxin-NADP+ reductase activity
EXW50_RS07510	COG0252	asparaginase activity
EXW50_RS07520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW50_RS07530	COG1304	FMN binding
EXW50_RS07560	COG1160	GTP binding
EXW50_RS07565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW50_RS07585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW50_RS07595	COG0302	gtp cyclohydrolase
EXW50_RS07600	COG0142	geranyltranstransferase activity
EXW50_RS07605	COG2226	methyltransferase
EXW50_RS07610	COG0142	geranyltranstransferase activity
EXW50_RS07625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW50_RS07635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW50_RS07640	COG0457	Tetratricopeptide repeat
EXW50_RS07645	COG5582	Belongs to the UPF0302 family
EXW50_RS07660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW50_RS07675	COG4347	Protein of unknown function (DUF1405)
EXW50_RS07690	COG2738	Putative neutral zinc metallopeptidase
EXW50_RS07700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS07705	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW50_RS07710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW50_RS07715	COG1803	Methylglyoxal synthase
EXW50_RS07720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW50_RS07725	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS07730	COG0617	tRNA 3'-terminal CCA addition
EXW50_RS07740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW50_RS07745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW50_RS07755	COG1199	ATP-dependent helicase activity
EXW50_RS07755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW50_RS07775	COG3935	DnaD domain protein
EXW50_RS07780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW50_RS07790	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW50_RS07790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW50_RS07795	COG3331	DNA recombination
EXW50_RS07830	COG4474	Belongs to the UPF0398 family
EXW50_RS07835	COG3599	regulation of cell shape
EXW50_RS07845	COG0116	Belongs to the methyltransferase superfamily
EXW50_RS07855	COG1199	ATP-dependent helicase activity
EXW50_RS07860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW50_RS07870	COG0024	Methionine aminopeptidase
EXW50_RS07880	COG2233	PERMEase
EXW50_RS07885	COG2311	Membrane
EXW50_RS07895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW50_RS07905	COG0456	acetyltransferase
EXW50_RS07955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW50_RS07970	COG0454	-acetyltransferase
EXW50_RS07990	COG0328	RNA-DNA hybrid ribonuclease activity
EXW50_RS08025	COG3403	YqcI/YcgG family
EXW50_RS08030	COG1280	lysine exporter protein (LysE YggA)
EXW50_RS08045	COG3162	membrane
EXW50_RS08050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW50_RS08055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW50_RS08065	COG0475	glutathione-regulated potassium exporter activity
EXW50_RS08070	COG4978	Transcriptional regulator
EXW50_RS08070	COG0789	Transcriptional regulator
EXW50_RS08075	COG0534	Mate efflux family protein
EXW50_RS08080	COG2323	membrane
EXW50_RS08085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW50_RS08110	COG2814	Major facilitator Superfamily
EXW50_RS08130	COG1923	regulation of RNA biosynthetic process
EXW50_RS08140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW50_RS08145	COG1360	Flagellar Motor Protein
EXW50_RS08150	COG2201	protein-glutamate methylesterase activity
EXW50_RS08155	COG0643	Histidine kinase
EXW50_RS08155	COG2198	Histidine kinase
EXW50_RS08160	COG1776	CheC inhibitor of MCP methylation
EXW50_RS08160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW50_RS08175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW50_RS08195	COG1256	bacterial-type flagellum assembly
EXW50_RS08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW50_RS08220	COG1815	bacterial-type flagellum-dependent cell motility
EXW50_RS08225	COG1558	bacterial-type flagellum-dependent cell motility
EXW50_RS08235	COG1766	The M ring may be actively involved in energy transduction
EXW50_RS08240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW50_RS08250	COG1157	protein secretion by the type III secretion system
EXW50_RS08270	COG1749	Flagellar hook protein flgE
EXW50_RS08285	COG0835	chemotaxis
EXW50_RS08285	COG0784	Response regulator, receiver
EXW50_RS08305	COG0861	Integral membrane protein TerC family
EXW50_RS08315	COG3383	formate dehydrogenase (NAD+) activity
EXW50_RS08320	COG2427	Protein of unknown function (DUF1641)
EXW50_RS08325	COG5609	conserved protein (DUF2294)
EXW50_RS08330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW50_RS08340	COG2116	formate transmembrane transporter activity
EXW50_RS08345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW50_RS08350	COG0303	'Molybdopterin
EXW50_RS08355	COG0314	molybdopterin synthase activity
EXW50_RS08370	COG0489	protein tyrosine kinase activity
EXW50_RS08410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW50_RS08415	COG0741	lytic transglycosylase activity
EXW50_RS08425	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW50_RS08430	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW50_RS08430	COG1776	CheC inhibitor of MCP methylation
EXW50_RS08440	COG1338	Plays a role in the flagellum-specific transport system
EXW50_RS08445	COG1987	bacterial-type flagellum assembly
EXW50_RS08455	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW50_RS08460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW50_RS08465	COG1419	protein localization to endoplasmic reticulum
EXW50_RS08470	COG4786	Flagellar basal body rod
EXW50_RS08485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW50_RS08525	COG0412	Dienelactone hydrolase
EXW50_RS08530	COG2329	Antibiotic biosynthesis monooxygenase
EXW50_RS08555	COG0583	DNA-binding transcription factor activity
EXW50_RS08560	COG3842	ATPase activity
EXW50_RS08610	COG0406	alpha-ribazole phosphatase activity
EXW50_RS08640	COG0367	asparagine synthase
EXW50_RS08670	COG1802	Transcriptional regulator
EXW50_RS08675	COG0697	spore germination
EXW50_RS08680	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS08680	COG1216	Glycosyl transferase, family 2
EXW50_RS08685	COG1757	Na H antiporter
EXW50_RS08710	COG0534	Mate efflux family protein
EXW50_RS08715	COG3340	Belongs to the peptidase S51 family
EXW50_RS08735	COG0785	Cytochrome C biogenesis protein
EXW50_RS08740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS08755	COG3048	D-serine ammonia-lyase activity
EXW50_RS08760	COG2733	membrane
EXW50_RS08795	COG1131	(ABC) transporter
EXW50_RS08815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW50_RS08820	COG0528	UMP kinase activity
EXW50_RS08830	COG1027	Aspartate ammonia-lyase
EXW50_RS08835	COG0281	malic enzyme
EXW50_RS08840	COG4191	Histidine kinase
EXW50_RS08845	COG0784	Response regulator, receiver
EXW50_RS08850	COG1846	Transcriptional regulator
EXW50_RS08860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW50_RS08870	COG2502	aspartate--ammonia ligase
EXW50_RS08875	COG3620	sequence-specific DNA binding
EXW50_RS08935	COG1695	Transcriptional regulator
EXW50_RS08950	COG0477	Major facilitator Superfamily
EXW50_RS08960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS08970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW50_RS08975	COG2223	nitrite transmembrane transporter activity
EXW50_RS08980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW50_RS08995	COG2244	polysaccharide biosynthetic process
EXW50_RS09000	COG0733	neurotransmitter:sodium symporter activity
EXW50_RS09010	COG5566	PFAM Mor transcription activator
EXW50_RS09015	COG2323	membrane
EXW50_RS09035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW50_RS09040	COG2132	Multicopper oxidase
EXW50_RS09050	COG5002	protein histidine kinase activity
EXW50_RS09055	COG0745	RESPONSE REGULATOR receiver
EXW50_RS09065	COG0129	dihydroxy-acid dehydratase activity
EXW50_RS09070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW50_RS09095	COG2814	Major facilitator Superfamily
EXW50_RS09100	COG3384	dioxygenase
EXW50_RS09135	COG1073	alpha beta
EXW50_RS09140	COG4166	transmembrane transport
EXW50_RS09145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS09150	COG0745	RESPONSE REGULATOR receiver
EXW50_RS09165	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW50_RS09170	COG1054	Belongs to the UPF0176 family
EXW50_RS09180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW50_RS09185	COG0531	amino acid
EXW50_RS09220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW50_RS09235	COG4257	antibiotic catabolic process
EXW50_RS09240	COG2390	Transcriptional regulator
EXW50_RS09250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW50_RS09255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS09260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW50_RS09275	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW50_RS09290	COG0583	DNA-binding transcription factor activity
EXW50_RS09305	COG0006	proline dipeptidase activity
EXW50_RS09310	COG2132	Multicopper oxidase
EXW50_RS09320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW50_RS09340	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS09350	COG2372	response to copper ion
EXW50_RS09350	COG1276	copper resistance
EXW50_RS09355	COG4549	nuclear export factor GLE1
EXW50_RS09365	COG0697	spore germination
EXW50_RS09370	COG0583	DNA-binding transcription factor activity
EXW50_RS09375	COG1959	2 iron, 2 sulfur cluster binding
EXW50_RS09380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW50_RS09385	COG0778	Nitroreductase
EXW50_RS09395	COG0628	permease
EXW50_RS09410	COG1231	oxidoreductase activity
EXW50_RS09415	COG0523	cobalamin synthesis protein
EXW50_RS09425	COG0411	ABC transporter
EXW50_RS09445	COG0583	DNA-binding transcription factor activity
EXW50_RS09455	COG1942	4-Oxalocrotonate Tautomerase
EXW50_RS09470	COG0346	lactoylglutathione lyase activity
EXW50_RS09480	COG1271	oxidase subunit
EXW50_RS09485	COG1294	oxidase, subunit
EXW50_RS09490	COG4988	ABC transporter
EXW50_RS09495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW50_RS09520	COG1686	Belongs to the peptidase S11 family
EXW50_RS09535	COG0791	NLP P60 protein
EXW50_RS09535	COG1388	LysM domain
EXW50_RS09545	COG1132	(ABC) transporter
EXW50_RS09550	COG0745	RESPONSE REGULATOR receiver
EXW50_RS09555	COG5002	protein histidine kinase activity
EXW50_RS09560	COG0300	oxidoreductase activity
EXW50_RS09565	COG4122	O-methyltransferase activity
EXW50_RS09585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EXW50_RS09595	COG0460	homoserine dehydrogenase
EXW50_RS09605	COG0083	homoserine kinase activity
EXW50_RS09620	COG1316	TRANSCRIPTIONal
EXW50_RS09635	COG1285	pathogenesis
EXW50_RS09640	COG1247	-acetyltransferase
EXW50_RS09660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW50_RS09670	COG1082	Xylose isomerase domain protein TIM barrel
EXW50_RS09680	COG2814	Major facilitator Superfamily
EXW50_RS09685	COG1279	arginine transmembrane transporter activity
EXW50_RS09690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS09700	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW50_RS09730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW50_RS09735	COG0577	efflux transmembrane transporter activity
EXW50_RS09740	COG2002	toxin-antitoxin pair type II binding
EXW50_RS09745	COG1404	Belongs to the peptidase S8 family
EXW50_RS09750	COG0640	Transcriptional regulator
EXW50_RS09755	COG0667	Aldo Keto reductase
EXW50_RS09795	COG3949	Membrane
EXW50_RS09800	COG0783	Belongs to the Dps family
EXW50_RS09815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW50_RS09825	COG1231	oxidoreductase activity
EXW50_RS09830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS09835	COG4989	oxidoreductase activity
EXW50_RS09840	COG0523	cobalamin synthesis protein
EXW50_RS09845	COG0456	acetyltransferase
EXW50_RS09850	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW50_RS09875	COG1136	(ABC) transporter
EXW50_RS09880	COG0577	efflux transmembrane transporter activity
EXW50_RS09885	COG0745	RESPONSE REGULATOR receiver
EXW50_RS09890	COG2205	protein histidine kinase activity
EXW50_RS09895	COG1902	pentaerythritol trinitrate reductase activity
EXW50_RS09900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW50_RS09910	COG4166	transmembrane transport
EXW50_RS09915	COG0346	lactoylglutathione lyase activity
EXW50_RS09925	COG0406	alpha-ribazole phosphatase activity
EXW50_RS09935	COG5337	Spore coat protein CotH
EXW50_RS09940	COG1051	belongs to the nudix hydrolase family
EXW50_RS09945	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS09950	COG2244	polysaccharide biosynthetic process
EXW50_RS09960	COG0701	Predicted permease
EXW50_RS09965	COG3689	TIGRFAM TIGR03943 family protein
EXW50_RS09970	COG1607	acyl-coa hydrolase
EXW50_RS09980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW50_RS09995	COG0702	epimerase
EXW50_RS10000	COG2839	Protein conserved in bacteria
EXW50_RS10005	COG1253	flavin adenine dinucleotide binding
EXW50_RS10030	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS10035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW50_RS10050	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS10060	COG1876	peptidase activity
EXW50_RS10065	COG0494	nUDIX hydrolase
EXW50_RS10075	COG2211	Major facilitator Superfamily
EXW50_RS10090	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS10100	COG0561	phosphatase activity
EXW50_RS10105	COG1846	Transcriptional regulator
EXW50_RS10110	COG2814	Major facilitator Superfamily
EXW50_RS10120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW50_RS10125	COG4106	trans-aconitate 2-methyltransferase activity
EXW50_RS10140	COG1819	glycosyl
EXW50_RS10145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS10150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS10175	COG0456	acetyltransferase
EXW50_RS10195	COG3874	Sporulation protein YtfJ
EXW50_RS10220	COG2226	methyltransferase
EXW50_RS10240	COG1082	Xylose isomerase domain protein TIM barrel
EXW50_RS10245	COG0346	lactoylglutathione lyase activity
EXW50_RS10255	COG0604	alcohol dehydrogenase
EXW50_RS10260	COG1595	DNA-templated transcription, initiation
EXW50_RS10280	COG0426	domain, Protein
EXW50_RS10280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW50_RS10290	COG0386	Belongs to the glutathione peroxidase family
EXW50_RS10295	COG1305	Transglutaminase-like
EXW50_RS10300	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW50_RS10305	COG0714	Associated with various cellular activities
EXW50_RS10310	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW50_RS10315	COG1140	nitrate reductase beta subunit
EXW50_RS10320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW50_RS10325	COG2181	nitrate reductase activity
EXW50_RS10330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW50_RS10335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW50_RS10340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW50_RS10345	COG0303	'Molybdopterin
EXW50_RS10350	COG0314	molybdopterin synthase activity
EXW50_RS10360	COG2223	nitrite transmembrane transporter activity
EXW50_RS10380	COG1648	precorrin-2 dehydrogenase activity
EXW50_RS10390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW50_RS10390	COG1587	Uroporphyrinogen-III synthase
EXW50_RS10395	COG2146	nitrite reductase [NAD(P)H] activity
EXW50_RS10400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW50_RS10405	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW50_RS10430	COG2359	stage V sporulation protein S
EXW50_RS10440	COG2856	Zn peptidase
EXW50_RS10530	COG0582	viral genome integration into host DNA
EXW50_RS10555	COG0582	viral genome integration into host DNA
EXW50_RS10565	COG5484	DNA packaging
EXW50_RS10570	COG1783	phage Terminase large subunit
EXW50_RS10585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW50_RS10590	COG4653	Phage capsid family
EXW50_RS10710	COG1418	mRNA catabolic process
EXW50_RS10715	COG0488	(ABC) transporter
EXW50_RS10735	COG1413	lyase activity
EXW50_RS10750	COG2136	Putative SAM-dependent methyltransferase
EXW50_RS10750	COG2521	methyltransferase
EXW50_RS10755	COG0018	arginyl-trna synthetase
EXW50_RS10805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW50_RS10810	COG0017	Asparaginyl-tRNA synthetase
EXW50_RS10815	COG0733	neurotransmitter:sodium symporter activity
EXW50_RS10840	COG2610	gluconate transmembrane transporter activity
EXW50_RS10850	COG1794	racemase activity, acting on amino acids and derivatives
EXW50_RS10860	COG0456	acetyltransferase
EXW50_RS10865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW50_RS10870	COG1131	(ABC) transporter
EXW50_RS10875	COG4473	ABC transporter
EXW50_RS10885	COG0546	phosphoglycolate phosphatase activity
EXW50_RS10930	COG0768	penicillin binding
EXW50_RS10940	COG0204	Acyl-transferase
EXW50_RS10945	COG1272	protein, Hemolysin III
EXW50_RS10950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW50_RS10955	COG0805	protein transport
EXW50_RS10970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW50_RS10975	COG1999	signal sequence binding
EXW50_RS10980	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW50_RS10985	COG0367	asparagine synthase
EXW50_RS11000	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS11005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS11010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW50_RS11030	COG1335	isochorismatase
EXW50_RS11040	COG0668	transmembrane transport
EXW50_RS11045	COG2203	Gaf domain
EXW50_RS11045	COG4585	Histidine kinase
EXW50_RS11050	COG2197	response regulator
EXW50_RS11055	COG1737	Transcriptional regulator
EXW50_RS11060	COG1064	alcohol dehydrogenase
EXW50_RS11075	COG1070	Carbohydrate kinase
EXW50_RS11085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW50_RS11105	COG0517	IMP dehydrogenase activity
EXW50_RS11105	COG1125	glycine betaine transport
EXW50_RS11110	COG1174	glycine betaine transport
EXW50_RS11145	COG1253	flavin adenine dinucleotide binding
EXW50_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS11155	COG5506	Protein of unknown function (DUF1694)
EXW50_RS11170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW50_RS11175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW50_RS11180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW50_RS11185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW50_RS11190	COG0456	acetyltransferase
EXW50_RS11195	COG3829	transcription factor binding
EXW50_RS11200	COG1509	lysine 2,3-aminomutase activity
EXW50_RS11210	COG4479	Belongs to the UPF0346 family
EXW50_RS11220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW50_RS11275	COG5293	efflux transmembrane transporter activity
EXW50_RS11315	COG4991	sh3 domain protein
EXW50_RS11315	COG3064	Membrane
EXW50_RS11315	COG0515	serine threonine protein kinase
EXW50_RS11325	COG0671	phosphoesterase, PA-phosphatase related
EXW50_RS11330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW50_RS11335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS11390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW50_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS11435	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW50_RS11435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW50_RS11445	COG2814	Major facilitator Superfamily
EXW50_RS11455	COG0372	Belongs to the citrate synthase family
EXW50_RS11460	COG2079	MmgE PrpD family protein
EXW50_RS11465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW50_RS11470	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS11475	COG2084	Dehydrogenase
EXW50_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS11485	COG1280	lysine exporter protein (LysE YggA)
EXW50_RS11490	COG1024	Enoyl-CoA hydratase
EXW50_RS11505	COG0420	3'-5' exonuclease activity
EXW50_RS11530	COG2223	nitrite transmembrane transporter activity
EXW50_RS11535	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS11540	COG1169	isochorismate synthase
EXW50_RS11545	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW50_RS11550	COG1535	isochorismatase
EXW50_RS11550	COG3433	isochorismatase activity
EXW50_RS11555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW50_RS11560	COG3251	PFAM MbtH domain protein
EXW50_RS11565	COG2814	Major facilitator Superfamily
EXW50_RS11580	COG0776	regulation of translation
EXW50_RS11590	COG2318	DinB family
EXW50_RS11595	COG1115	amino acid carrier protein
EXW50_RS11610	COG2329	Antibiotic biosynthesis monooxygenase
EXW50_RS11620	COG1187	pseudouridine synthase activity
EXW50_RS11625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW50_RS11630	COG3655	Transcriptional regulator
EXW50_RS11640	COG1136	(ABC) transporter
EXW50_RS11650	COG0596	Alpha beta hydrolase
EXW50_RS11665	COG0028	Belongs to the TPP enzyme family
EXW50_RS11685	COG1253	flavin adenine dinucleotide binding
EXW50_RS11730	COG1846	Transcriptional regulator
EXW50_RS11740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS11745	COG1309	transcriptional regulator
EXW50_RS11755	COG0697	spore germination
EXW50_RS11760	COG0531	amino acid
EXW50_RS11775	COG1247	-acetyltransferase
EXW50_RS11810	COG0596	Alpha beta hydrolase
EXW50_RS11815	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW50_RS11825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS11855	COG0583	DNA-binding transcription factor activity
EXW50_RS11860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW50_RS11875	COG0583	DNA-binding transcription factor activity
EXW50_RS11880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW50_RS11885	COG2258	MOSC domain
EXW50_RS11895	COG1132	(ABC) transporter
EXW50_RS11900	COG1132	(ABC) transporter
EXW50_RS11920	COG1396	sequence-specific DNA binding
EXW50_RS11955	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW50_RS11960	COG1595	DNA-templated transcription, initiation
EXW50_RS11985	COG1649	PFAM Uncharacterised BCR, COG1649
EXW50_RS12005	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW50_RS12010	COG2971	BadF BadG BcrA BcrD
EXW50_RS12070	COG0500	methyltransferase
EXW50_RS12070	COG3615	Tellurite resistance protein tehB
EXW50_RS12080	COG0693	protein deglycase activity
EXW50_RS12090	COG0588	phosphoglycerate mutase activity
EXW50_RS12115	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW50_RS12125	COG0110	maltose O-acetyltransferase activity
EXW50_RS12130	COG1136	(ABC) transporter
EXW50_RS12155	COG1686	Belongs to the peptidase S11 family
EXW50_RS12180	COG0768	penicillin binding
EXW50_RS12185	COG0745	RESPONSE REGULATOR receiver
EXW50_RS12190	COG2205	protein histidine kinase activity
EXW50_RS12195	COG1136	(ABC) transporter
EXW50_RS12200	COG0577	efflux transmembrane transporter activity
EXW50_RS12210	COG1595	DNA-templated transcription, initiation
EXW50_RS12220	COG0768	penicillin binding
EXW50_RS12225	COG0768	penicillin binding
EXW50_RS12260	COG1252	NADH dehydrogenase
EXW50_RS12265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS12265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS12280	COG0697	spore germination
EXW50_RS12310	COG3397	chitin binding
EXW50_RS12315	COG0823	Involved in the tonB-independent uptake of proteins
EXW50_RS12325	COG1408	metallophosphoesterase
EXW50_RS12335	COG1131	(ABC) transporter
EXW50_RS12345	COG1309	transcriptional regulator
EXW50_RS12355	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS12360	COG0439	Biotin carboxylase
EXW50_RS12365	COG0511	ligase activity, forming carbon-carbon bonds
EXW50_RS12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW50_RS12375	COG1024	Enoyl-CoA hydratase
EXW50_RS12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW50_RS12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW50_RS12430	COG0572	uridine kinase
EXW50_RS12465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW50_RS12495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW50_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS12525	COG1733	regulation of RNA biosynthetic process
EXW50_RS12550	COG1309	transcriptional regulator
EXW50_RS12580	COG0697	spore germination
EXW50_RS12585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS12615	COG2323	membrane
EXW50_RS12630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS12635	COG0697	spore germination
EXW50_RS12655	COG0201	protein transport
EXW50_RS12665	COG0737	Belongs to the 5'-nucleotidase family
EXW50_RS12670	COG3227	Zinc metalloprotease (Elastase)
EXW50_RS12675	COG1523	belongs to the glycosyl hydrolase 13 family
EXW50_RS12695	COG1073	alpha beta
EXW50_RS12705	COG0577	efflux transmembrane transporter activity
EXW50_RS12710	COG1136	(ABC) transporter
EXW50_RS12740	COG5002	protein histidine kinase activity
EXW50_RS12745	COG0745	RESPONSE REGULATOR receiver
EXW50_RS12750	COG1011	Hydrolase
EXW50_RS12775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW50_RS12780	COG1183	phosphatidylcholine synthase activity
EXW50_RS12795	COG1132	(ABC) transporter
EXW50_RS12800	COG3961	Belongs to the TPP enzyme family
EXW50_RS12820	COG0322	excinuclease ABC activity
EXW50_RS12845	COG2318	DinB family
EXW50_RS12860	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW50_RS12885	COG3878	Protein conserved in bacteria
EXW50_RS12905	COG1051	belongs to the nudix hydrolase family
EXW50_RS12910	COG0592	DNA-directed DNA polymerase activity
EXW50_RS12915	COG2816	NAD+ diphosphatase activity
EXW50_RS12925	COG2223	nitrite transmembrane transporter activity
EXW50_RS12935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW50_RS12945	COG0494	nUDIX hydrolase
EXW50_RS12965	COG0697	spore germination
EXW50_RS12970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS12985	COG0584	glycerophosphoryl diester phosphodiesterase
EXW50_RS13000	COG1733	regulation of RNA biosynthetic process
EXW50_RS13010	COG2814	Major facilitator Superfamily
EXW50_RS13020	COG1132	(ABC) transporter
EXW50_RS13020	COG2375	cellular response to nickel ion
EXW50_RS13025	COG1132	(ABC) transporter
EXW50_RS13060	COG0768	penicillin binding
EXW50_RS13065	COG0671	phosphoesterase, PA-phosphatase related
EXW50_RS13070	COG0604	alcohol dehydrogenase
EXW50_RS13075	COG5002	protein histidine kinase activity
EXW50_RS13080	COG0745	RESPONSE REGULATOR receiver
EXW50_RS13090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW50_RS13100	COG2205	protein histidine kinase activity
EXW50_RS13115	COG1122	ATPase activity
EXW50_RS13120	COG4720	Psort location CytoplasmicMembrane, score
EXW50_RS13125	COG1794	racemase activity, acting on amino acids and derivatives
EXW50_RS13130	COG1819	glycosyl
EXW50_RS13140	COG0768	penicillin binding
EXW50_RS13145	COG5002	protein histidine kinase activity
EXW50_RS13180	COG0561	phosphatase activity
EXW50_RS13225	COG2124	cytochrome p450
EXW50_RS13275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW50_RS13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS13290	COG0460	homoserine dehydrogenase
EXW50_RS13310	COG0577	efflux transmembrane transporter activity
EXW50_RS13315	COG1136	(ABC) transporter
EXW50_RS13325	COG0488	(ABC) transporter
EXW50_RS13330	COG0667	Aldo Keto reductase
EXW50_RS13335	COG0583	DNA-binding transcription factor activity
EXW50_RS13340	COG2205	protein histidine kinase activity
EXW50_RS13345	COG0745	RESPONSE REGULATOR receiver
EXW50_RS13355	COG3773	Cell wall hydrolase
EXW50_RS13360	COG0604	alcohol dehydrogenase
EXW50_RS13390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS13405	COG2959	enzyme of heme biosynthesis
EXW50_RS13430	COG3483	tryptophan 2,3-dioxygenase activity
EXW50_RS13435	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW50_RS13440	COG3844	kynureninase activity
EXW50_RS13445	COG1309	transcriptional regulator
EXW50_RS13480	COG1349	DNA-binding transcription factor activity
EXW50_RS13505	COG2223	nitrite transmembrane transporter activity
EXW50_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS13520	COG0456	acetyltransferase
EXW50_RS13520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW50_RS13555	COG4176	ABC-type proline glycine betaine transport system permease component
EXW50_RS13560	COG0517	IMP dehydrogenase activity
EXW50_RS13560	COG4175	Glycine betaine
EXW50_RS13585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW50_RS13590	COG2153	protein acetylation
EXW50_RS13595	COG3397	chitin binding
EXW50_RS13605	COG1819	glycosyl
EXW50_RS13620	COG2205	protein histidine kinase activity
EXW50_RS13625	COG2315	Protein conserved in bacteria
EXW50_RS13665	COG3973	AAA domain
EXW50_RS13680	COG2105	PFAM AIG2 family protein
EXW50_RS13685	COG0514	ATP-dependent DNA helicase (RecQ)
EXW50_RS13710	COG4637	Psort location Cytoplasmic, score
EXW50_RS13730	COG1227	inorganic diphosphatase activity
EXW50_RS13735	COG3397	chitin binding
EXW50_RS13740	COG2318	DinB family
EXW50_RS13760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW50_RS13765	COG1115	amino acid carrier protein
EXW50_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS13775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW50_RS13785	COG3938	Belongs to the proline racemase family
EXW50_RS13790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW50_RS13835	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS13850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW50_RS13855	COG4166	transmembrane transport
EXW50_RS13865	COG4948	Mandelate Racemase Muconate Lactonizing
EXW50_RS13885	COG0667	Aldo Keto reductase
EXW50_RS13930	COG2936	dipeptidyl-peptidase activity
EXW50_RS13935	COG5002	protein histidine kinase activity
EXW50_RS13940	COG0745	RESPONSE REGULATOR receiver
EXW50_RS13970	COG1164	Oligoendopeptidase f
EXW50_RS13990	COG1307	EDD domain protein, DegV family
EXW50_RS14015	COG1335	isochorismatase
EXW50_RS14030	COG2814	Major facilitator Superfamily
EXW50_RS14040	COG1664	Polymer-forming cytoskeletal
EXW50_RS14045	COG0789	Transcriptional regulator
EXW50_RS14050	COG4533	DNA binding
EXW50_RS14055	COG2814	Major facilitator Superfamily
EXW50_RS14055	COG0477	Major facilitator Superfamily
EXW50_RS14070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW50_RS14075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW50_RS14080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW50_RS14085	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS14100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW50_RS14105	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS14110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW50_RS14125	COG2261	transglycosylase associated protein
EXW50_RS14140	COG2226	methyltransferase
EXW50_RS14175	COG0436	Aminotransferase
EXW50_RS14180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW50_RS14205	COG1131	(ABC) transporter
EXW50_RS14210	COG2188	Transcriptional regulator
EXW50_RS14255	COG0628	permease
EXW50_RS14285	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW50_RS14295	COG0697	spore germination
EXW50_RS14300	COG2318	DinB family
EXW50_RS14330	COG0346	lactoylglutathione lyase activity
EXW50_RS14335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS14365	COG2814	Major facilitator Superfamily
EXW50_RS14370	COG1368	sulfuric ester hydrolase activity
EXW50_RS14385	COG0488	(ABC) transporter
EXW50_RS14390	COG1033	growth of symbiont in host cell
EXW50_RS14390	COG2409	Drug exporters of the RND superfamily
EXW50_RS14395	COG1309	transcriptional regulator
EXW50_RS14415	COG0287	Prephenate dehydrogenase
EXW50_RS14430	COG1605	Chorismate mutase
EXW50_RS14430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW50_RS14475	COG3584	3D domain protein
EXW50_RS14475	COG1388	LysM domain
EXW50_RS14485	COG0346	lactoylglutathione lyase activity
EXW50_RS14520	COG0579	oxidoreductase
EXW50_RS14545	COG1830	Aldolase
EXW50_RS14550	COG2226	methyltransferase
EXW50_RS14565	COG0346	lactoylglutathione lyase activity
EXW50_RS14570	COG2329	Antibiotic biosynthesis monooxygenase
EXW50_RS14590	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW50_RS14595	COG2207	Transcriptional regulator
EXW50_RS14600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS14605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW50_RS14610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW50_RS14615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW50_RS14620	COG3239	Fatty acid desaturase
EXW50_RS14630	COG3655	Transcriptional regulator
EXW50_RS14645	COG4377	Putative membrane peptidase family (DUF2324)
EXW50_RS14655	COG3279	Response regulator of the LytR AlgR family
EXW50_RS14670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS14675	COG0346	lactoylglutathione lyase activity
EXW50_RS14705	COG0714	Associated with various cellular activities
EXW50_RS14725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW50_RS14730	COG0753	catalase activity
EXW50_RS14740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW50_RS14760	COG0778	Nitroreductase
EXW50_RS14765	COG1846	Transcriptional regulator
EXW50_RS14780	COG0494	nUDIX hydrolase
EXW50_RS14800	COG1725	Transcriptional regulator
EXW50_RS14830	COG2207	Transcriptional regulator
EXW50_RS14835	COG0456	acetyltransferase
EXW50_RS14850	COG0697	spore germination
EXW50_RS14855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS14860	COG1671	Belongs to the UPF0178 family
EXW50_RS14880	COG0456	acetyltransferase
EXW50_RS14880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW50_RS14905	COG0730	response to heat
EXW50_RS14915	COG0833	amino acid
EXW50_RS14925	COG4335	DNA alkylation repair
EXW50_RS14955	COG0768	penicillin binding
EXW50_RS14965	COG3104	oligopeptide transport
EXW50_RS14970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW50_RS14985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW50_RS14990	COG1984	allophanate hydrolase subunit 2
EXW50_RS14995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW50_RS15000	COG1414	Transcriptional regulator
EXW50_RS15020	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS15045	COG0640	Transcriptional regulator
EXW50_RS15065	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW50_RS15080	COG0574	Belongs to the PEP-utilizing enzyme family
EXW50_RS15080	COG3848	Pyruvate phosphate dikinase
EXW50_RS15105	COG1136	(ABC) transporter
EXW50_RS15135	COG1073	alpha beta
EXW50_RS15170	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW50_RS15190	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW50_RS15195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW50_RS15200	COG1121	(ABC) transporter
EXW50_RS15215	COG1999	signal sequence binding
EXW50_RS15220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW50_RS15225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW50_RS15250	COG0798	PFAM Bile acid sodium symporter
EXW50_RS15255	COG0346	lactoylglutathione lyase activity
EXW50_RS15260	COG0640	Transcriptional regulator
EXW50_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS15320	COG1522	sequence-specific DNA binding
EXW50_RS15335	COG0346	lactoylglutathione lyase activity
EXW50_RS15355	COG2226	methyltransferase
EXW50_RS15365	COG2814	Major facilitator Superfamily
EXW50_RS15395	COG0745	RESPONSE REGULATOR receiver
EXW50_RS15400	COG3850	Histidine kinase
EXW50_RS15400	COG5002	protein histidine kinase activity
EXW50_RS15430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW50_RS15470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW50_RS15480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS15500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW50_RS15520	COG1136	(ABC) transporter
EXW50_RS15525	COG0577	efflux transmembrane transporter activity
EXW50_RS15545	COG5002	protein histidine kinase activity
EXW50_RS15545	COG3850	Histidine kinase
EXW50_RS15560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS15575	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW50_RS15595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW50_RS15655	COG2814	Major facilitator Superfamily
EXW50_RS15670	COG1876	peptidase activity
EXW50_RS15675	COG2843	Capsule synthesis protein
EXW50_RS15690	COG0477	Major facilitator Superfamily
EXW50_RS15705	COG1846	Transcriptional regulator
EXW50_RS15710	COG2814	Major facilitator Superfamily
EXW50_RS15725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXW50_RS15735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS15745	COG0789	Transcriptional regulator
EXW50_RS15775	COG1476	TRANSCRIPTIONal
EXW50_RS15790	COG1288	antiporter activity
EXW50_RS15795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW50_RS15840	COG3718	enzyme involved in inositol metabolism
EXW50_RS15845	COG0191	fructose-bisphosphate aldolase activity
EXW50_RS15870	COG0673	inositol 2-dehydrogenase activity
EXW50_RS15875	COG2814	Major facilitator Superfamily
EXW50_RS15880	COG1609	Transcriptional regulator
EXW50_RS15885	COG2003	Belongs to the UPF0758 family
EXW50_RS15940	COG0494	nUDIX hydrolase
EXW50_RS15970	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS16005	COG0739	heme binding
EXW50_RS16055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW50_RS16110	COG4187	Peptidase family M20/M25/M40
EXW50_RS16125	COG2031	fatty acid transporter
EXW50_RS16135	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW50_RS16195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW50_RS16200	COG1288	antiporter activity
EXW50_RS16205	COG2356	endonuclease I
EXW50_RS16210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW50_RS16230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW50_RS16250	COG1785	Belongs to the alkaline phosphatase family
EXW50_RS16255	COG0778	Nitroreductase
EXW50_RS16260	COG1733	regulation of RNA biosynthetic process
EXW50_RS16275	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS16285	COG1131	(ABC) transporter
EXW50_RS16305	COG0494	nUDIX hydrolase
EXW50_RS16320	COG1011	Hydrolase
EXW50_RS16325	COG2365	Tyrosine phosphatase family
EXW50_RS16350	COG0346	lactoylglutathione lyase activity
EXW50_RS16355	COG1940	carbohydrate kinase activity
EXW50_RS16360	COG0738	Major facilitator superfamily
EXW50_RS16365	COG0110	maltose O-acetyltransferase activity
EXW50_RS16380	COG0628	permease
EXW50_RS16385	COG2261	transglycosylase associated protein
EXW50_RS16425	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW50_RS16435	COG1253	flavin adenine dinucleotide binding
EXW50_RS16440	COG0789	Transcriptional regulator
EXW50_RS16445	COG0697	spore germination
EXW50_RS16450	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW50_RS16455	COG3813	Protein conserved in bacteria
EXW50_RS16460	COG2706	6-phosphogluconolactonase activity
EXW50_RS16465	COG1070	Carbohydrate kinase
EXW50_RS16475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW50_RS16480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW50_RS16495	COG0814	amino acid
EXW50_RS16515	COG1393	Belongs to the ArsC family
EXW50_RS16525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS16540	COG0494	nUDIX hydrolase
EXW50_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS16575	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS16580	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW50_RS16585	COG1733	regulation of RNA biosynthetic process
EXW50_RS16600	COG1191	sigma factor activity
EXW50_RS16620	COG1876	peptidase activity
EXW50_RS16645	COG0741	lytic transglycosylase activity
EXW50_RS16665	COG5002	protein histidine kinase activity
EXW50_RS16670	COG0745	RESPONSE REGULATOR receiver
EXW50_RS16685	COG0657	acetylesterase activity
EXW50_RS16695	COG2814	Major facilitator Superfamily
EXW50_RS16700	COG1309	transcriptional regulator
EXW50_RS16720	COG3226	Transcriptional regulator
EXW50_RS16725	COG1280	lysine exporter protein (LysE YggA)
EXW50_RS16750	COG0814	amino acid
EXW50_RS16775	COG1151	hydroxylamine reductase activity
EXW50_RS16815	COG2072	flavoprotein involved in K transport
EXW50_RS16860	COG1695	Transcriptional regulator
EXW50_RS16865	COG0604	alcohol dehydrogenase
EXW50_RS16870	COG1113	amino acid transport
EXW50_RS16880	COG2814	Major facilitator Superfamily
EXW50_RS16910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW50_RS16915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW50_RS16935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS16940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS16945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS16950	COG3739	integral membrane protein
EXW50_RS16975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS16980	COG0583	DNA-binding transcription factor activity
EXW50_RS17005	COG1193	negative regulation of DNA recombination
EXW50_RS17025	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW50_RS17030	COG1164	Oligoendopeptidase f
EXW50_RS17035	COG2957	Belongs to the agmatine deiminase family
EXW50_RS17055	COG3781	membrane
EXW50_RS17070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW50_RS17105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW50_RS17110	COG0640	Transcriptional regulator
EXW50_RS17115	COG0604	alcohol dehydrogenase
EXW50_RS17120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW50_RS17130	COG0457	Tetratricopeptide repeat
EXW50_RS17135	COG2808	Putative FMN-binding domain
EXW50_RS17145	COG0277	FAD linked oxidase domain protein
EXW50_RS17165	COG1285	pathogenesis
EXW50_RS17175	COG2514	catechol 2,3-dioxygenase activity
EXW50_RS17180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS17185	COG1126	abc transporter atp-binding protein
EXW50_RS17190	COG0765	amino acid transport
EXW50_RS17195	COG2720	vancomycin resistance protein
EXW50_RS17220	COG1278	Cold shock
EXW50_RS17230	COG0716	FMN binding
EXW50_RS17240	COG0494	nUDIX hydrolase
EXW50_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS17270	COG0165	Argininosuccinate lyase
EXW50_RS17285	COG4145	pantothenate transmembrane transporter activity
EXW50_RS17295	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS17300	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS17310	COG1657	PFAM Prenyltransferase squalene oxidase
EXW50_RS17315	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW50_RS17320	COG2962	Rard protein
EXW50_RS17325	COG3326	Membrane
EXW50_RS17330	COG0531	amino acid
EXW50_RS17360	COG2226	methyltransferase
EXW50_RS17365	COG4166	transmembrane transport
EXW50_RS17370	COG4166	transmembrane transport
EXW50_RS17375	COG4166	transmembrane transport
EXW50_RS17385	COG1131	(ABC) transporter
EXW50_RS17405	COG0673	inositol 2-dehydrogenase activity
EXW50_RS17410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW50_RS17415	COG0187	DNA topoisomerase II activity
EXW50_RS17420	COG1832	CoA-binding protein
EXW50_RS17425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW50_RS17430	COG0745	RESPONSE REGULATOR receiver
EXW50_RS17440	COG1328	CTP reductase activity
EXW50_RS17440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW50_RS17450	COG4841	protein insertion into membrane
EXW50_RS17455	COG0824	Thioesterase
EXW50_RS17480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS17495	COG1266	CAAX protease self-immunity
EXW50_RS17500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW50_RS17530	COG2211	Major facilitator Superfamily
EXW50_RS17540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW50_RS17555	COG0183	Belongs to the thiolase family
EXW50_RS17560	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS17565	COG1268	BioY protein
EXW50_RS17570	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS17575	COG1396	sequence-specific DNA binding
EXW50_RS17615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS17625	COG5002	protein histidine kinase activity
EXW50_RS17635	COG0400	carboxylic ester hydrolase activity
EXW50_RS17640	COG0346	lactoylglutathione lyase activity
EXW50_RS17650	COG0069	glutamate synthase activity
EXW50_RS17655	COG1902	pentaerythritol trinitrate reductase activity
EXW50_RS17660	COG1329	Transcriptional regulator
EXW50_RS17665	COG0010	Belongs to the arginase family
EXW50_RS17675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW50_RS17680	COG2986	histidine ammonia-lyase
EXW50_RS17690	COG2226	methyltransferase
EXW50_RS17715	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW50_RS17720	COG0785	Cytochrome C biogenesis protein
EXW50_RS17730	COG1473	amidohydrolase
EXW50_RS17735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW50_RS17740	COG1131	(ABC) transporter
EXW50_RS17750	COG0583	DNA-binding transcription factor activity
EXW50_RS17760	COG1346	cytolysis
EXW50_RS17775	COG0730	response to heat
EXW50_RS17785	COG3409	Peptidoglycan-binding domain 1 protein
EXW50_RS17785	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW50_RS17805	COG1132	(ABC) transporter
EXW50_RS17810	COG1132	(ABC) transporter
EXW50_RS17830	COG4886	Leucine-rich repeat (LRR) protein
EXW50_RS17830	COG4932	domain protein
EXW50_RS17905	COG3763	UPF0154 protein
EXW50_RS17925	COG3639	organic phosphonate transmembrane transporter activity
EXW50_RS17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS17940	COG0737	Belongs to the 5'-nucleotidase family
EXW50_RS17950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW50_RS17955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW50_RS17970	COG1695	Transcriptional regulator
EXW50_RS17975	COG1132	(ABC) transporter
EXW50_RS18010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW50_RS18020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW50_RS18025	COG3420	alginic acid biosynthetic process
EXW50_RS18025	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW50_RS18055	COG1216	Glycosyl transferase, family 2
EXW50_RS18075	COG0463	Glycosyl transferase, family 2
EXW50_RS18075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW50_RS18080	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS18085	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS18090	COG1086	Polysaccharide biosynthesis protein
EXW50_RS18095	COG0489	protein tyrosine kinase activity
EXW50_RS18100	COG3944	biosynthesis protein
EXW50_RS18105	COG0174	glutamine synthetase
EXW50_RS18110	COG0789	Transcriptional regulator
EXW50_RS18115	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW50_RS18120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW50_RS18125	COG2860	membrane
EXW50_RS18135	COG0464	growth
EXW50_RS18155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW50_RS18165	COG3584	3D domain protein
EXW50_RS18165	COG1388	LysM domain
EXW50_RS18170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW50_RS18170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW50_RS18170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW50_RS18175	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW50_RS18180	COG1349	DNA-binding transcription factor activity
EXW50_RS18185	COG1979	alcohol dehydrogenase
EXW50_RS18190	COG2322	membrane
EXW50_RS18200	COG1113	amino acid transport
EXW50_RS18210	COG1473	amidohydrolase
EXW50_RS18215	COG1408	metallophosphoesterase
EXW50_RS18220	COG2116	formate transmembrane transporter activity
EXW50_RS18235	COG2217	Heavy metal translocating P-type atpase
EXW50_RS18240	COG2608	mercury ion transmembrane transporter activity
EXW50_RS18245	COG1937	Protein conserved in bacteria
EXW50_RS18275	COG4566	intracellular signal transduction
EXW50_RS18280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW50_RS18285	COG2819	hydrolase of the alpha beta superfamily
EXW50_RS18290	COG1120	ATPase activity
EXW50_RS18295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS18300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS18305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS18310	COG0708	Exodeoxyribonuclease III
EXW50_RS18315	COG2169	Transcriptional regulator
EXW50_RS18320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW50_RS18325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW50_RS18335	COG2706	6-phosphogluconolactonase activity
EXW50_RS18340	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW50_RS18345	COG2364	Membrane
EXW50_RS18365	COG0346	lactoylglutathione lyase activity
EXW50_RS18370	COG5001	Diguanylate cyclase
EXW50_RS18370	COG3300	MHYT domain
EXW50_RS18410	COG1346	cytolysis
EXW50_RS18420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW50_RS18425	COG0596	Alpha beta hydrolase
EXW50_RS18425	COG2945	thiolester hydrolase activity
EXW50_RS18430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW50_RS18440	COG2188	Transcriptional regulator
EXW50_RS18445	COG2723	6-phospho-beta-galactosidase activity
EXW50_RS18450	COG0840	transmembrane signaling receptor activity
EXW50_RS18460	COG3773	Cell wall hydrolase
EXW50_RS18470	COG1368	sulfuric ester hydrolase activity
EXW50_RS18475	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW50_RS18485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW50_RS18490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW50_RS18495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW50_RS18505	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW50_RS18510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW50_RS18515	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW50_RS18520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW50_RS18520	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW50_RS18530	COG2359	stage V sporulation protein S
EXW50_RS18535	COG1692	metallophosphoesterase
EXW50_RS18540	COG1418	mRNA catabolic process
EXW50_RS18545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW50_RS18550	COG1058	Belongs to the CinA family
EXW50_RS18550	COG1546	Belongs to the CinA family
EXW50_RS18555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW50_RS18560	COG1426	Protein conserved in bacteria
EXW50_RS18575	COG0300	oxidoreductase activity
EXW50_RS18580	COG0612	Peptidase, M16
EXW50_RS18585	COG0612	Peptidase, M16
EXW50_RS18590	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW50_RS18595	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW50_RS18600	COG3845	ABC transporter
EXW50_RS18605	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW50_RS18610	COG2188	Transcriptional regulator
EXW50_RS18615	COG1674	ftsk spoiiie
EXW50_RS18625	COG0740	serine-type endopeptidase activity
EXW50_RS18630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW50_RS18640	COG0527	aspartate kinase activity
EXW50_RS18645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW50_RS18650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW50_RS18655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW50_RS18660	COG1873	PFAM PRC-barrel domain
EXW50_RS18665	COG0612	Peptidase, M16
EXW50_RS18670	COG0726	polysaccharide deacetylase
EXW50_RS18675	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW50_RS18685	COG0196	riboflavin kinase activity
EXW50_RS18695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW50_RS18700	COG1550	Protein conserved in bacteria
EXW50_RS18705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW50_RS18710	COG1358	cellular component organization or biogenesis
EXW50_RS18715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW50_RS18720	COG0195	Participates in both transcription termination and antitermination
EXW50_RS18725	COG0779	Required for maturation of 30S ribosomal subunits
EXW50_RS18735	COG0442	prolyl-tRNA aminoacylation
EXW50_RS18740	COG0750	zinc metalloprotease
EXW50_RS18750	COG4589	Belongs to the CDS family
EXW50_RS18760	COG0233	cytoplasmic translational termination
EXW50_RS18765	COG0528	UMP kinase activity
EXW50_RS18770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW50_RS18775	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW50_RS18780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW50_RS18785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW50_RS18790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW50_RS18795	COG4974	Belongs to the 'phage' integrase family
EXW50_RS18800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW50_RS18805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW50_RS18810	COG0758	DNA mediated transformation
EXW50_RS18815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW50_RS18820	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW50_RS18825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW50_RS18840	COG0335	large ribosomal subunit rRNA binding
EXW50_RS18845	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW50_RS18850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW50_RS18855	COG1837	Belongs to the UPF0109 family
EXW50_RS18865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW50_RS18870	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW50_RS18875	COG0552	protein localization to endoplasmic reticulum
EXW50_RS18880	COG1196	nuclear chromosome segregation
EXW50_RS18885	COG0571	ribonuclease III activity
EXW50_RS18890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW50_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS18900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW50_RS18905	COG0416	fatty acid biosynthetic process
EXW50_RS18910	COG2050	protein possibly involved in aromatic compounds catabolism
EXW50_RS18910	COG1349	DNA-binding transcription factor activity
EXW50_RS18915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW50_RS18920	COG1461	Dihydroxyacetone kinase
EXW50_RS18925	COG1302	Protein conserved in bacteria
EXW50_RS18940	COG1564	THIamine pyrophosphokinase
EXW50_RS18945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW50_RS18955	COG2815	serine threonine protein kinase
EXW50_RS18955	COG0515	serine threonine protein kinase
EXW50_RS18960	COG0631	protein serine/threonine phosphatase activity
EXW50_RS18965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW50_RS18970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW50_RS18970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW50_RS18975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW50_RS18980	COG0242	peptide deformylase activity
EXW50_RS18985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW50_RS18990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW50_RS18995	COG1758	RNA polymerase activity
EXW50_RS19010	COG1561	YicC-like family, N-terminal region
EXW50_RS19015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW50_RS19030	COG0006	proline dipeptidase activity
EXW50_RS19075	COG0167	dihydroorotate dehydrogenase activity
EXW50_RS19080	COG0543	2 iron, 2 sulfur cluster binding
EXW50_RS19085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW50_RS19095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW50_RS19100	COG0540	Belongs to the ATCase OTCase family
EXW50_RS19110	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW50_RS19115	COG0564	pseudouridine synthase activity
EXW50_RS19120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW50_RS19130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW50_RS19135	COG3599	regulation of cell shape
EXW50_RS19140	COG2302	S4 RNA-binding domain
EXW50_RS19145	COG0762	integral membrane protein
EXW50_RS19150	COG1799	cell septum assembly
EXW50_RS19155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW50_RS19165	COG1873	PFAM PRC-barrel domain
EXW50_RS19170	COG1191	sigma factor activity
EXW50_RS19175	COG1191	sigma factor activity
EXW50_RS19185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW50_RS19190	COG0849	cell division
EXW50_RS19195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW50_RS19210	COG0772	Belongs to the SEDS family
EXW50_RS19215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW50_RS19220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW50_RS19225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW50_RS19230	COG0768	penicillin binding
EXW50_RS19235	COG0768	penicillin binding
EXW50_RS19245	COG0275	rRNA processing
EXW50_RS19250	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW50_RS19255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW50_RS19260	COG0454	-acetyltransferase
EXW50_RS19270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW50_RS19275	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW50_RS19280	COG1323	Belongs to the UPF0348 family
EXW50_RS19285	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW50_RS19290	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW50_RS19295	COG3314	Sporulation integral membrane protein YlbJ
EXW50_RS19300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXW50_RS19305	COG0742	ribosomal rna small subunit methyltransferase
EXW50_RS19315	COG4471	UPF0298 protein
EXW50_RS19320	COG3679	Belongs to the UPF0342 family
EXW50_RS19325	COG0406	alpha-ribazole phosphatase activity
EXW50_RS19340	COG2340	Cysteine-rich secretory protein family
EXW50_RS19350	COG3336	cytochrome c oxidase
EXW50_RS19375	COG0109	protoheme IX farnesyltransferase activity
EXW50_RS19380	COG1612	heme a metabolic process
EXW50_RS19385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW50_RS19390	COG0772	Belongs to the SEDS family
EXW50_RS19395	COG4838	Belongs to the UPF0358 family
EXW50_RS19400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW50_RS19405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW50_RS19415	COG4896	Protein conserved in bacteria
EXW50_RS19430	COG1217	gtp-binding protein TYPA
EXW50_RS19440	COG0483	inositol monophosphate 1-phosphatase activity
EXW50_RS19450	COG4493	Belongs to the UPF0637 family
EXW50_RS19455	COG4476	Belongs to the UPF0223 family
EXW50_RS19460	COG1982	Orn Lys Arg decarboxylase major
EXW50_RS19505	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW50_RS19510	COG0022	dehydrogenase e1 component
EXW50_RS19515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW50_RS19530	COG0561	phosphatase activity
EXW50_RS19535	COG5503	Protein of unknown function (DUF1447)
EXW50_RS19540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW50_RS19545	COG0569	domain protein
EXW50_RS19555	COG1473	amidohydrolase
EXW50_RS19560	COG2171	N-acyltransferase activity
EXW50_RS19565	COG0583	DNA-binding transcription factor activity
EXW50_RS19570	COG0517	IMP dehydrogenase activity
EXW50_RS19580	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW50_RS19590	COG4703	Protein of unknown function (DUF1797)
EXW50_RS19605	COG2200	EAL domain
EXW50_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS19615	COG1408	metallophosphoesterase
EXW50_RS19660	COG2814	Major facilitator Superfamily
EXW50_RS19670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW50_RS19680	COG3209	COG3209 Rhs family protein
EXW50_RS19690	COG2205	protein histidine kinase activity
EXW50_RS19700	COG0436	Aminotransferase
EXW50_RS19705	COG1609	Transcriptional regulator
EXW50_RS19710	COG3833	ABC-type maltose transport systems, permease component
EXW50_RS19715	COG1175	transmembrane transport
EXW50_RS19720	COG2182	Extracellular solute-binding protein
EXW50_RS19730	COG0366	Alpha amylase catalytic
EXW50_RS19735	COG3842	ATPase activity
EXW50_RS19775	COG0183	Belongs to the thiolase family
EXW50_RS19810	COG1695	Transcriptional regulator
EXW50_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS19825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW50_RS19830	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW50_RS19835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW50_RS19840	COG0436	Aminotransferase
EXW50_RS19845	COG1850	ribulose-bisphosphate carboxylase activity
EXW50_RS19850	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW50_RS19855	COG0235	Class ii aldolase
EXW50_RS19860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW50_RS19875	COG2084	Dehydrogenase
EXW50_RS19885	COG2199	diguanylate cyclase activity
EXW50_RS19890	COG0778	Nitroreductase
EXW50_RS19915	COG1263	PTS System
EXW50_RS19915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW50_RS19915	COG2190	(PTS) system
EXW50_RS19920	COG3711	transcriptional antiterminator
EXW50_RS19930	COG2188	Transcriptional regulator
EXW50_RS19935	COG0363	glucosamine-6-phosphate deaminase activity
EXW50_RS19940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW50_RS19950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW50_RS19955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW50_RS19965	COG1547	Domain of unknown function (DUF309)
EXW50_RS19975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW50_RS19980	COG4086	secreted protein
EXW50_RS19985	COG0561	phosphatase activity
EXW50_RS19990	COG0697	spore germination
EXW50_RS20005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS20030	COG0733	neurotransmitter:sodium symporter activity
EXW50_RS20050	COG1686	Belongs to the peptidase S11 family
EXW50_RS20055	COG1725	Transcriptional regulator
EXW50_RS20060	COG1131	(ABC) transporter
EXW50_RS20080	COG1846	Transcriptional regulator
EXW50_RS20095	COG0598	Magnesium transport protein CorA
EXW50_RS20110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW50_RS20120	COG4974	Belongs to the 'phage' integrase family
EXW50_RS20130	COG0735	belongs to the Fur family
EXW50_RS20135	COG1300	Membrane
EXW50_RS20155	COG0667	Aldo Keto reductase
EXW50_RS20160	COG0656	L-ascorbic acid biosynthetic process
EXW50_RS20165	COG0456	acetyltransferase
EXW50_RS20165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW50_RS20175	COG0737	Belongs to the 5'-nucleotidase family
EXW50_RS20175	COG1525	nuclease
EXW50_RS20175	COG4085	toxin activity
EXW50_RS20180	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW50_RS20190	COG0596	Alpha beta hydrolase
EXW50_RS20195	COG2056	Na+-H+ antiporter family
EXW50_RS20200	COG1609	Transcriptional regulator
EXW50_RS20205	COG0456	acetyltransferase
EXW50_RS20210	COG1073	alpha beta
EXW50_RS20225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW50_RS20225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW50_RS20230	COG0307	riboflavin synthase, alpha
EXW50_RS20235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW50_RS20235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW50_RS20250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW50_RS20255	COG4106	trans-aconitate 2-methyltransferase activity
EXW50_RS20260	COG2226	methyltransferase
EXW50_RS20260	COG1073	alpha beta
EXW50_RS20265	COG0156	8-amino-7-oxononanoate synthase activity
EXW50_RS20275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW50_RS20285	COG1757	Na H antiporter
EXW50_RS20290	COG0737	Belongs to the 5'-nucleotidase family
EXW50_RS20300	COG1522	sequence-specific DNA binding
EXW50_RS20325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW50_RS20335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW50_RS20345	COG0300	oxidoreductase activity
EXW50_RS20350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS20355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW50_RS20360	COG1760	l-serine dehydratase
EXW50_RS20365	COG1760	l-serine dehydratase
EXW50_RS20375	COG1234	tRNA 3'-trailer cleavage
EXW50_RS20410	COG1131	(ABC) transporter
EXW50_RS20425	COG1285	pathogenesis
EXW50_RS20440	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW50_RS20445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS20460	COG1376	ErfK ybiS ycfS ynhG family protein
EXW50_RS20465	COG4129	membrane
EXW50_RS20470	COG1126	abc transporter atp-binding protein
EXW50_RS20475	COG0765	amino acid transport
EXW50_RS20480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW50_RS20495	COG2323	membrane
EXW50_RS20500	COG0772	Belongs to the SEDS family
EXW50_RS20505	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW50_RS20510	COG0022	dehydrogenase e1 component
EXW50_RS20515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW50_RS20520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW50_RS20525	COG3426	butyrate kinase activity
EXW50_RS20535	COG0280	phosphate acetyltransferase
EXW50_RS20540	COG3829	transcription factor binding
EXW50_RS20540	COG3290	protein histidine kinase activity
EXW50_RS20550	COG0584	glycerophosphoryl diester phosphodiesterase
EXW50_RS20555	COG3093	addiction module antidote protein HigA
EXW50_RS20565	COG0745	RESPONSE REGULATOR receiver
EXW50_RS20570	COG0750	zinc metalloprotease
EXW50_RS20575	COG0497	DNA recombination
EXW50_RS20580	COG1438	arginine binding
EXW50_RS20585	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW50_RS20590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW50_RS20595	COG0142	geranyltranstransferase activity
EXW50_RS20600	COG1722	exodeoxyribonuclease VII activity
EXW50_RS20605	COG1570	exodeoxyribonuclease VII activity
EXW50_RS20610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW50_RS20615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW50_RS20620	COG1302	Protein conserved in bacteria
EXW50_RS20625	COG0439	Biotin carboxylase
EXW50_RS20630	COG0511	ligase activity, forming carbon-carbon bonds
EXW50_RS20675	COG3854	ATPases associated with a variety of cellular activities
EXW50_RS20695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW50_RS20700	COG0006	proline dipeptidase activity
EXW50_RS20705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW50_RS20715	COG3872	metal-dependent enzyme
EXW50_RS20725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW50_RS20730	COG1321	iron dependent repressor
EXW50_RS20760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS20770	COG1609	Transcriptional regulator
EXW50_RS20780	COG2076	Multidrug Resistance protein
EXW50_RS20785	COG2076	Multidrug Resistance protein
EXW50_RS20820	COG1725	Transcriptional regulator
EXW50_RS20835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW50_RS20840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW50_RS20845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW50_RS20850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW50_RS20875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW50_RS20900	COG4970	Tfp pilus assembly protein FimT
EXW50_RS20910	COG1459	type II secretion system
EXW50_RS20915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW50_RS20970	COG0646	methionine synthase
EXW50_RS20970	COG1410	methionine synthase
EXW50_RS20975	COG0646	methionine synthase
EXW50_RS20975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW50_RS20980	COG0626	cystathionine gamma-synthase activity
EXW50_RS20985	COG0626	cystathionine gamma-synthase activity
EXW50_RS21000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS21010	COG1940	carbohydrate kinase activity
EXW50_RS21015	COG4483	Protein conserved in bacteria
EXW50_RS21020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW50_RS21025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW50_RS21030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW50_RS21035	COG0704	Plays a role in the regulation of phosphate uptake
EXW50_RS21050	COG0581	inorganic phosphate transmembrane transporter activity
EXW50_RS21055	COG0573	inorganic phosphate transmembrane transporter activity
EXW50_RS21060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW50_RS21065	COG0768	penicillin binding
EXW50_RS21070	COG0477	Major facilitator Superfamily
EXW50_RS21075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW50_RS21095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW50_RS21100	COG0735	belongs to the Fur family
EXW50_RS21105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW50_RS21110	COG1121	(ABC) transporter
EXW50_RS21115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS21125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW50_RS21140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW50_RS21145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW50_RS21150	COG2384	SAM-dependent methyltransferase
EXW50_RS21160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW50_RS21165	COG0358	DNA primase activity
EXW50_RS21175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW50_RS21180	COG0517	IMP dehydrogenase activity
EXW50_RS21185	COG1381	Involved in DNA repair and RecF pathway recombination
EXW50_RS21195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW50_RS21200	COG0295	cytidine deaminase activity
EXW50_RS21205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW50_RS21210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW50_RS21215	COG1480	7TM receptor with intracellular HD hydrolase
EXW50_RS21220	COG1702	phosphate starvation-inducible protein PhoH
EXW50_RS21235	COG1610	YqeY-like protein
EXW50_RS21240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW50_RS21245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW50_RS21250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW50_RS21260	COG0484	heat shock protein binding
EXW50_RS21265	COG0443	Heat shock 70 kDa protein
EXW50_RS21275	COG1420	regulation of RNA biosynthetic process
EXW50_RS21280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW50_RS21285	COG1733	regulation of RNA biosynthetic process
EXW50_RS21290	COG0481	GTPase activity
EXW50_RS21300	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW50_RS21305	COG0268	Binds directly to 16S ribosomal RNA
EXW50_RS21310	COG1466	dna polymerase III delta subunit
EXW50_RS21320	COG0658	competence protein
EXW50_RS21320	COG2333	competence protein COMEC
EXW50_RS21325	COG2131	deaminase
EXW50_RS21330	COG1555	photosystem II stabilization
EXW50_RS21330	COG1596	polysaccharide export
EXW50_RS21335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW50_RS21340	COG2226	methyltransferase
EXW50_RS21345	COG0799	negative regulation of ribosome biogenesis
EXW50_RS21350	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW50_RS21355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW50_RS21360	COG1534	Rna-binding protein
EXW50_RS21365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW50_RS21370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW50_RS21375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW50_RS21385	COG0688	phosphatidylethanolamine metabolic process
EXW50_RS21395	COG1595	DNA-templated transcription, initiation
EXW50_RS21400	COG2357	RelA SpoT domain protein
EXW50_RS21410	COG1785	Belongs to the alkaline phosphatase family
EXW50_RS21420	COG2267	carboxylic ester hydrolase activity
EXW50_RS21455	COG1404	Belongs to the peptidase S8 family
EXW50_RS21460	COG3186	Phenylalanine-4-hydroxylase
EXW50_RS21465	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW50_RS21470	COG2514	catechol 2,3-dioxygenase activity
EXW50_RS21475	COG2259	Doxx family
EXW50_RS21515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS21525	COG1012	belongs to the aldehyde dehydrogenase family
EXW50_RS21525	COG1454	alcohol dehydrogenase
EXW50_RS21530	COG0626	cystathionine gamma-synthase activity
EXW50_RS21535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW50_RS21540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW50_RS21545	COG2226	methyltransferase
EXW50_RS21560	COG0768	penicillin binding
EXW50_RS21565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW50_RS21570	COG0572	uridine kinase
EXW50_RS21575	COG0826	peptidase U32
EXW50_RS21580	COG0826	peptidase U32
EXW50_RS21585	COG4122	O-methyltransferase activity
EXW50_RS21590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW50_RS21600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW50_RS21605	COG4472	Bacterial protein of unknown function (DUF965)
EXW50_RS21610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW50_RS21620	COG0628	permease
EXW50_RS21640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW50_RS21650	COG0482	sulfurtransferase activity
EXW50_RS21655	COG1104	cysteine desulfurase activity
EXW50_RS21660	COG1959	2 iron, 2 sulfur cluster binding
EXW50_RS21665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW50_RS21675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW50_RS21680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW50_RS21695	COG1490	D-aminoacyl-tRNA deacylase activity
EXW50_RS21700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW50_RS21705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW50_RS21710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW50_RS21710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW50_RS21715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW50_RS21720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW50_RS21720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW50_RS21730	COG2244	polysaccharide biosynthetic process
EXW50_RS21735	COG2323	membrane
EXW50_RS21745	COG1862	Preprotein translocase
EXW50_RS21750	COG0343	queuine tRNA-ribosyltransferase activity
EXW50_RS21755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW50_RS21765	COG2255	four-way junction helicase activity
EXW50_RS21770	COG0632	four-way junction helicase activity
EXW50_RS21775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW50_RS21800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW50_RS21805	COG0157	Belongs to the NadC ModD family
EXW50_RS21810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW50_RS21815	COG1104	cysteine desulfurase activity
EXW50_RS21820	COG1827	regulation of RNA biosynthetic process
EXW50_RS21825	COG2258	MOSC domain
EXW50_RS21830	COG0077	Prephenate dehydratase
EXW50_RS21835	COG0577	efflux transmembrane transporter activity
EXW50_RS21840	COG0577	efflux transmembrane transporter activity
EXW50_RS21845	COG1136	(ABC) transporter
EXW50_RS21850	COG5002	protein histidine kinase activity
EXW50_RS21855	COG0745	RESPONSE REGULATOR receiver
EXW50_RS21860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW50_RS21865	COG3290	protein histidine kinase activity
EXW50_RS21875	COG2868	ribosomal protein
EXW50_RS21885	COG1530	ribonuclease E activity
EXW50_RS21890	COG1994	Peptidase M50
EXW50_RS21895	COG0739	heme binding
EXW50_RS21900	COG2894	cell division
EXW50_RS21905	COG0850	regulation of cytokinetic process
EXW50_RS21920	COG1077	Cell shape determining protein MreB Mrl
EXW50_RS21925	COG2003	Belongs to the UPF0758 family
EXW50_RS21930	COG0424	maF-like protein
EXW50_RS21940	COG0285	dihydrofolate synthase activity
EXW50_RS21955	COG1388	LysM domain
EXW50_RS21960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW50_RS21965	COG0113	porphobilinogen synthase activity
EXW50_RS21970	COG1587	Uroporphyrinogen-III synthase
EXW50_RS21975	COG0181	hydroxymethylbilane synthase activity
EXW50_RS21980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW50_RS21985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW50_RS21990	COG1846	Transcriptional regulator
EXW50_RS21995	COG1764	response to oxidative stress
EXW50_RS22000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW50_RS22010	COG1067	ATP-dependent peptidase activity
EXW50_RS22010	COG0470	DNA polymerase III
EXW50_RS22020	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW50_RS22050	COG0622	Phosphoesterase
EXW50_RS22060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW50_RS22065	COG5401	PFAM Sporulation and spore germination
EXW50_RS22075	COG0477	Major facilitator Superfamily
EXW50_RS22085	COG1309	transcriptional regulator
EXW50_RS22095	COG2197	response regulator
EXW50_RS22100	COG2233	PERMEase
EXW50_RS22105	COG0402	S-adenosylhomocysteine deaminase activity
EXW50_RS22110	COG1983	PspC domain protein
EXW50_RS22115	COG1396	sequence-specific DNA binding
EXW50_RS22120	COG0697	spore germination
EXW50_RS22130	COG1959	2 iron, 2 sulfur cluster binding
EXW50_RS22135	COG1668	transmembrane transport
EXW50_RS22140	COG4152	abc transporter atp-binding protein
EXW50_RS22145	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW50_RS22150	COG1360	Flagellar Motor Protein
EXW50_RS22155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW50_RS22160	COG1876	peptidase activity
EXW50_RS22165	COG0824	Thioesterase
EXW50_RS22170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW50_RS22175	COG1053	succinate dehydrogenase
EXW50_RS22180	COG2009	succinate dehydrogenase
EXW50_RS22185	COG1719	4-vinyl reductase, 4VR
EXW50_RS22190	COG0322	excinuclease ABC activity
EXW50_RS22195	COG3118	belongs to the thioredoxin family
EXW50_RS22200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW50_RS22205	COG2086	electron transfer activity
EXW50_RS22210	COG1024	Enoyl-CoA hydratase
EXW50_RS22215	COG1309	transcriptional regulator
EXW50_RS22220	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS22245	COG2318	DinB family
EXW50_RS22275	COG1131	(ABC) transporter
EXW50_RS22280	COG2205	protein histidine kinase activity
EXW50_RS22285	COG0745	RESPONSE REGULATOR receiver
EXW50_RS22295	COG4895	conserved protein (DUF2196)
EXW50_RS22300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW50_RS22305	COG2329	Antibiotic biosynthesis monooxygenase
EXW50_RS22310	COG4509	Sortase family
EXW50_RS22315	COG1120	ATPase activity
EXW50_RS22330	COG5386	Cell surface protein
EXW50_RS22340	COG5386	Cell surface protein
EXW50_RS22345	COG1114	Component of the transport system for branched-chain amino acids
EXW50_RS22355	COG1193	negative regulation of DNA recombination
EXW50_RS22360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW50_RS22360	COG1796	DNA polymerase
EXW50_RS22365	COG1286	toxin biosynthetic process
EXW50_RS22370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW50_RS22375	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW50_RS22400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW50_RS22405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW50_RS22415	COG1418	mRNA catabolic process
EXW50_RS22445	COG2814	Major facilitator Superfamily
EXW50_RS22450	COG1566	PFAM secretion protein HlyD family protein
EXW50_RS22455	COG1309	transcriptional regulator
EXW50_RS22460	COG1363	Peptidase, m42
EXW50_RS22470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW50_RS22485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW50_RS22495	COG1484	DNA-dependent DNA replication
EXW50_RS22500	COG3611	Membrane attachment protein
EXW50_RS22505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW50_RS22510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW50_RS22515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW50_RS22520	COG0237	dephospho-CoA kinase activity
EXW50_RS22525	COG1971	Probably functions as a manganese efflux pump
EXW50_RS22535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW50_RS22535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW50_RS22540	COG5002	protein histidine kinase activity
EXW50_RS22545	COG0745	RESPONSE REGULATOR receiver
EXW50_RS22560	COG0039	L-malate dehydrogenase activity
EXW50_RS22565	COG0538	isocitrate dehydrogenase activity
EXW50_RS22570	COG0372	Belongs to the citrate synthase family
EXW50_RS22580	COG0628	permease
EXW50_RS22585	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW50_RS22595	COG0205	6-phosphofructokinase activity
EXW50_RS22605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW50_RS22610	COG1725	Transcriptional regulator
EXW50_RS22615	COG0281	malic enzyme
EXW50_RS22620	COG0587	DNA-directed DNA polymerase activity
EXW50_RS22635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW50_RS22650	COG4109	DRTGG domain
EXW50_RS22660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW50_RS22665	COG0006	proline dipeptidase activity
EXW50_RS22710	COG0662	Cupin 2, conserved barrel domain protein
EXW50_RS22720	COG1476	TRANSCRIPTIONal
EXW50_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
EXW50_RS22740	COG0589	response to stress
EXW50_RS22760	COG0165	Argininosuccinate lyase
EXW50_RS22765	COG0137	argininosuccinate synthase activity
EXW50_RS22780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS22795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW50_RS22800	COG0827	DNA restriction-modification system
EXW50_RS22805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW50_RS22810	COG3874	Sporulation protein YtfJ
EXW50_RS22825	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW50_RS22835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW50_RS22850	COG1104	cysteine desulfurase activity
EXW50_RS22855	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW50_RS22870	COG1309	transcriptional regulator
EXW50_RS22875	COG1956	GAF domain-containing protein
EXW50_RS22880	COG0626	cystathionine gamma-synthase activity
EXW50_RS22885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW50_RS22910	COG1595	DNA-templated transcription, initiation
EXW50_RS22920	COG0110	maltose O-acetyltransferase activity
EXW50_RS22925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW50_RS22930	COG0454	-acetyltransferase
EXW50_RS22935	COG0517	IMP dehydrogenase activity
EXW50_RS22940	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW50_RS22955	COG0745	RESPONSE REGULATOR receiver
EXW50_RS22960	COG5002	protein histidine kinase activity
EXW50_RS22965	COG0666	response to abiotic stimulus
EXW50_RS22975	COG1970	mechanosensitive ion channel activity
EXW50_RS23000	COG1609	Transcriptional regulator
EXW50_RS23015	COG4851	CamS sex pheromone cAM373 precursor
EXW50_RS23020	COG3118	belongs to the thioredoxin family
EXW50_RS23030	COG2309	aminopeptidase activity
EXW50_RS23055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS23060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW50_RS23070	COG1674	ftsk spoiiie
EXW50_RS23085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW50_RS23090	COG4848	Belongs to the UPF0354 family
EXW50_RS23095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS23100	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW50_RS23105	COG1363	Peptidase, m42
EXW50_RS23115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS23120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW50_RS23130	COG0510	thiamine kinase activity
EXW50_RS23135	COG1523	belongs to the glycosyl hydrolase 13 family
EXW50_RS23145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW50_RS23150	COG1349	DNA-binding transcription factor activity
EXW50_RS23155	COG1187	pseudouridine synthase activity
EXW50_RS23160	COG2244	polysaccharide biosynthetic process
EXW50_RS23165	COG2081	HI0933 family
EXW50_RS23170	COG2814	Major facilitator Superfamily
EXW50_RS23180	COG3832	glyoxalase III activity
EXW50_RS23200	COG1329	Transcriptional regulator
EXW50_RS23225	COG0314	molybdopterin synthase activity
EXW50_RS23230	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW50_RS23235	COG0303	'Molybdopterin
EXW50_RS23240	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW50_RS23245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW50_RS23250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW50_RS23270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW50_RS23280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW50_RS23320	COG0495	leucyl-tRNA aminoacylation
EXW50_RS23325	COG2814	Major facilitator Superfamily
EXW50_RS23330	COG0475	glutathione-regulated potassium exporter activity
EXW50_RS23335	COG0490	domain, Protein
EXW50_RS23340	COG0582	viral genome integration into host DNA
EXW50_RS23350	COG1136	(ABC) transporter
EXW50_RS23370	COG1242	4 iron, 4 sulfur cluster binding
EXW50_RS23375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW50_RS23380	COG1794	racemase activity, acting on amino acids and derivatives
EXW50_RS23395	COG2267	carboxylic ester hydrolase activity
EXW50_RS23400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW50_RS23405	COG0671	phosphoesterase, PA-phosphatase related
EXW50_RS23410	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS23435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW50_RS23440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW50_RS23465	COG5002	protein histidine kinase activity
EXW50_RS23470	COG3852	Histidine kinase
EXW50_RS23475	COG0753	catalase activity
EXW50_RS23480	COG2267	carboxylic ester hydrolase activity
EXW50_RS23485	COG1368	sulfuric ester hydrolase activity
EXW50_RS23490	COG4895	conserved protein (DUF2196)
EXW50_RS23505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW50_RS23510	COG1116	anion transmembrane transporter activity
EXW50_RS23515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW50_RS23540	COG0494	nUDIX hydrolase
EXW50_RS23575	COG2076	Multidrug Resistance protein
EXW50_RS23585	COG0789	Transcriptional regulator
EXW50_RS23590	COG1854	S-ribosylhomocysteine lyase activity
EXW50_RS23600	COG0288	reversible hydration of carbon dioxide
EXW50_RS23605	COG1271	oxidase subunit
EXW50_RS23610	COG1294	oxidase, subunit
EXW50_RS23625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS23650	COG1842	Phage shock protein A
EXW50_RS23680	COG5002	protein histidine kinase activity
EXW50_RS23685	COG0745	RESPONSE REGULATOR receiver
EXW50_RS23710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW50_RS23715	COG1597	lipid kinase activity
EXW50_RS23730	COG1136	(ABC) transporter
EXW50_RS23760	COG5002	protein histidine kinase activity
EXW50_RS23770	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS23785	COG0577	efflux transmembrane transporter activity
EXW50_RS23790	COG1136	(ABC) transporter
EXW50_RS23795	COG3708	Transcriptional regulator
EXW50_RS23795	COG2207	Transcriptional regulator
EXW50_RS23805	COG1131	(ABC) transporter
EXW50_RS23810	COG5658	integral membrane protein
EXW50_RS23815	COG0640	Transcriptional regulator
EXW50_RS23820	COG0745	RESPONSE REGULATOR receiver
EXW50_RS23825	COG2205	protein histidine kinase activity
EXW50_RS23830	COG0577	efflux transmembrane transporter activity
EXW50_RS23835	COG0577	efflux transmembrane transporter activity
EXW50_RS23840	COG1136	(ABC) transporter
EXW50_RS23845	COG0577	efflux transmembrane transporter activity
EXW50_RS23860	COG2188	Transcriptional regulator
EXW50_RS23880	COG3964	amidohydrolase
EXW50_RS23900	COG4948	Mandelate Racemase Muconate Lactonizing
EXW50_RS23905	COG0318	PFAM AMP-dependent synthetase and ligase
EXW50_RS23910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW50_RS23915	COG0596	Alpha beta hydrolase
EXW50_RS23920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW50_RS23925	COG1169	isochorismate synthase
EXW50_RS23930	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW50_RS23935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW50_RS23940	COG1278	Cold shock
EXW50_RS23960	COG0058	SHG alpha-glucan phosphorylase activity
EXW50_RS23970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW50_RS23975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW50_RS23980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW50_RS23995	COG1309	transcriptional regulator
EXW50_RS24135	COG1285	pathogenesis
EXW50_RS24140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW50_RS24150	COG0166	Belongs to the GPI family
EXW50_RS24155	COG2155	Conserved Protein
EXW50_RS24160	COG1098	S1 RNA binding domain
EXW50_RS24165	COG0436	Aminotransferase
EXW50_RS24170	COG1522	sequence-specific DNA binding
EXW50_RS24175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW50_RS24180	COG2267	carboxylic ester hydrolase activity
EXW50_RS24190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW50_RS24210	COG5018	Exonuclease
EXW50_RS24215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW50_RS24235	COG2050	protein possibly involved in aromatic compounds catabolism
EXW50_RS24245	COG1268	BioY protein
EXW50_RS24250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW50_RS24255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW50_RS24265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW50_RS24270	COG3584	3D domain protein
EXW50_RS24285	COG1252	NADH dehydrogenase
EXW50_RS24290	COG0492	ferredoxin-NADP+ reductase activity
EXW50_RS24310	COG1683	Conserved Protein
EXW50_RS24330	COG0316	Belongs to the HesB IscA family
EXW50_RS24335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW50_RS24340	COG4844	belongs to the
EXW50_RS24345	COG1252	NADH dehydrogenase
EXW50_RS24355	COG0390	transport system, permease component
EXW50_RS24360	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW50_RS24390	COG4837	Protein of unknown function (DUF1462)
EXW50_RS24395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW50_RS24405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW50_RS24410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW50_RS24430	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW50_RS24440	COG0647	UMP catabolic process
EXW50_RS24450	COG2445	Protein of unknown function DUF86
EXW50_RS24455	COG1494	fructose-1,6-bisphosphatase
EXW50_RS24470	COG4470	Protein conserved in bacteria
EXW50_RS24480	COG0789	Transcriptional regulator
EXW50_RS24485	COG4377	Putative membrane peptidase family (DUF2324)
EXW50_RS24505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW50_RS24510	COG0739	heme binding
EXW50_RS24520	COG3377	Domain of unknown function (DUF1805)
EXW50_RS24525	COG0737	Belongs to the 5'-nucleotidase family
EXW50_RS24530	COG1695	Transcriptional regulator
EXW50_RS24540	COG0719	Fe-S assembly protein
EXW50_RS24545	COG0822	iron-sulfur transferase activity
EXW50_RS24550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW50_RS24555	COG0719	Fe-S assembly protein
EXW50_RS24560	COG0396	ATPase activity
EXW50_RS24565	COG1464	Belongs to the NlpA lipoprotein family
EXW50_RS24570	COG1464	Belongs to the NlpA lipoprotein family
EXW50_RS24575	COG2011	ABC-type metal ion transport system permease component
EXW50_RS24580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW50_RS24590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW50_RS24595	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW50_RS24600	COG0509	glycine decarboxylation via glycine cleavage system
EXW50_RS24605	COG1393	Belongs to the ArsC family
EXW50_RS24650	COG1309	transcriptional regulator
EXW50_RS24655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW50_RS24660	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS24665	COG0183	Belongs to the thiolase family
EXW50_RS24670	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW50_RS24670	COG1024	Enoyl-CoA hydratase
EXW50_RS24680	COG1686	Belongs to the peptidase S11 family
EXW50_RS24685	COG0506	proline dehydrogenase activity
EXW50_RS24695	COG0011	TIGRFAM Protein of
EXW50_RS24700	COG0840	transmembrane signaling receptor activity
EXW50_RS24715	COG2814	Major facilitator Superfamily
EXW50_RS24720	COG0531	amino acid
EXW50_RS24745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW50_RS24775	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS24785	COG1376	ErfK ybiS ycfS ynhG family protein
EXW50_RS24790	COG0745	RESPONSE REGULATOR receiver
EXW50_RS24795	COG5002	protein histidine kinase activity
EXW50_RS24805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW50_RS24815	COG0840	transmembrane signaling receptor activity
EXW50_RS24820	COG0840	transmembrane signaling receptor activity
EXW50_RS24825	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW50_RS24830	COG3227	Zinc metalloprotease (Elastase)
EXW50_RS24835	COG1741	Belongs to the pirin family
EXW50_RS24850	COG0586	Pfam SNARE associated Golgi protein
EXW50_RS24855	COG0475	glutathione-regulated potassium exporter activity
EXW50_RS24860	COG0490	domain, Protein
EXW50_RS24865	COG1115	amino acid carrier protein
EXW50_RS24870	COG0783	Belongs to the Dps family
EXW50_RS24880	COG2318	DinB family
EXW50_RS24890	COG1611	Belongs to the LOG family
EXW50_RS24900	COG1528	Iron-storage protein
EXW50_RS24905	COG2311	Membrane
EXW50_RS24910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS24915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS24920	COG1115	amino acid carrier protein
EXW50_RS24925	COG1115	amino acid carrier protein
EXW50_RS24930	COG2910	NAD(P)H-binding
EXW50_RS24950	COG0656	L-ascorbic acid biosynthetic process
EXW50_RS24955	COG2814	Major facilitator Superfamily
EXW50_RS24960	COG1733	regulation of RNA biosynthetic process
EXW50_RS24970	COG1252	NADH dehydrogenase
EXW50_RS24990	COG3290	protein histidine kinase activity
EXW50_RS24990	COG0840	transmembrane signaling receptor activity
EXW50_RS25000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW50_RS25005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW50_RS25020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW50_RS25035	COG4224	UPF0291 protein
EXW50_RS25040	COG1335	isochorismatase
EXW50_RS25045	COG1522	sequence-specific DNA binding
EXW50_RS25055	COG1522	sequence-specific DNA binding
EXW50_RS25060	COG0288	reversible hydration of carbon dioxide
EXW50_RS25065	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW50_RS25070	COG2233	PERMEase
EXW50_RS25110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW50_RS25115	COG0557	exoribonuclease II activity
EXW50_RS25120	COG1647	Serine aminopeptidase, S33
EXW50_RS25125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW50_RS25130	COG1346	cytolysis
EXW50_RS25145	COG0148	phosphopyruvate hydratase activity
EXW50_RS25155	COG0149	triose-phosphate isomerase activity
EXW50_RS25160	COG0126	phosphoglycerate kinase activity
EXW50_RS25165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW50_RS25180	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW50_RS25210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS25225	COG2323	membrane
EXW50_RS25235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW50_RS25240	COG1481	regulation of sporulation
EXW50_RS25245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW50_RS25250	COG1660	Displays ATPase and GTPase activities
EXW50_RS25255	COG1051	belongs to the nudix hydrolase family
EXW50_RS25265	COG0492	ferredoxin-NADP+ reductase activity
EXW50_RS25270	COG0457	Tetratricopeptide repeat
EXW50_RS25275	COG0110	maltose O-acetyltransferase activity
EXW50_RS25280	COG0546	phosphoglycolate phosphatase activity
EXW50_RS25285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW50_RS25290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW50_RS25295	COG1950	PFAM Membrane protein of
EXW50_RS25300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW50_RS25320	COG0789	Transcriptional regulator
EXW50_RS25355	COG0583	DNA-binding transcription factor activity
EXW50_RS25360	COG0789	Transcriptional regulator
EXW50_RS25365	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW50_RS25370	COG0488	(ABC) transporter
EXW50_RS25380	COG1132	(ABC) transporter
EXW50_RS25385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW50_RS25390	COG3409	Peptidoglycan-binding domain 1 protein
EXW50_RS25390	COG0793	Belongs to the peptidase S41A family
EXW50_RS25395	COG2177	Part of the ABC transporter FtsEX involved in
EXW50_RS25400	COG2884	Cell division ATP-binding protein ftsE
EXW50_RS25425	COG1131	(ABC) transporter
EXW50_RS25460	COG1278	Cold shock
EXW50_RS25465	COG1040	competence protein
EXW50_RS25470	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW50_RS25475	COG0791	NLP P60 protein
EXW50_RS25475	COG1388	LysM domain
EXW50_RS25480	COG1733	regulation of RNA biosynthetic process
EXW50_RS25485	COG1307	EDD domain protein, DegV family
EXW50_RS25490	COG1739	Uncharacterized protein family UPF0029
EXW50_RS25495	COG1316	TRANSCRIPTIONal
EXW50_RS25500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW50_RS25505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW50_RS25510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW50_RS25520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW50_RS25520	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW50_RS25540	COG1486	melibiose metabolic process
EXW50_RS25545	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW50_RS25550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW50_RS25560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW50_RS25570	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW50_RS25580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW50_RS25585	COG1301	dicarboxylic acid transport
EXW50_RS25600	COG1511	domain protein
EXW50_RS25605	COG0583	DNA-binding transcription factor activity
EXW50_RS25610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW50_RS25620	COG1271	oxidase subunit
EXW50_RS25625	COG1294	oxidase, subunit
EXW50_RS25630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW50_RS25635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW50_RS25640	COG1620	l-lactate permease
EXW50_RS25650	COG2389	metal-binding protein
EXW50_RS25660	COG1368	sulfuric ester hydrolase activity
EXW50_RS25670	COG0791	NLP P60 protein
EXW50_RS25670	COG1388	LysM domain
EXW50_RS25675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW50_RS25685	COG1215	transferase activity, transferring glycosyl groups
EXW50_RS25690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW50_RS25695	COG3584	3D domain protein
EXW50_RS25695	COG1388	LysM domain
EXW50_RS25720	COG4715	Zinc finger, swim domain protein
EXW50_RS25725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW50_RS25775	COG0577	efflux transmembrane transporter activity
EXW50_RS25780	COG1136	(ABC) transporter
EXW50_RS25800	COG2271	Major facilitator Superfamily
EXW50_RS25815	COG3850	Histidine kinase
EXW50_RS25815	COG5002	protein histidine kinase activity
EXW50_RS25820	COG0745	RESPONSE REGULATOR receiver
EXW50_RS25825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW50_RS25840	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW50_RS25855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW50_RS25870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW50_RS25880	COG1316	TRANSCRIPTIONal
EXW50_RS25890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EXW50_RS25900	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EXW50_RS25905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW50_RS25925	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS25935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW50_RS25945	COG1086	Polysaccharide biosynthesis protein
EXW50_RS25955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW50_RS25960	COG1086	Polysaccharide biosynthesis protein
EXW50_RS25965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW50_RS25970	COG4464	protein tyrosine phosphatase activity
EXW50_RS25975	COG0489	protein tyrosine kinase activity
EXW50_RS25980	COG3944	biosynthesis protein
EXW50_RS25985	COG0489	protein tyrosine kinase activity
EXW50_RS26000	COG1609	Transcriptional regulator
EXW50_RS26010	COG0739	heme binding
EXW50_RS26025	COG3279	Response regulator of the LytR AlgR family
EXW50_RS26030	COG2385	sporulation resulting in formation of a cellular spore
EXW50_RS26045	COG4836	Membrane
EXW50_RS26050	COG1007	ATP synthesis coupled electron transport
EXW50_RS26055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW50_RS26060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW50_RS26065	COG0713	ATP synthesis coupled electron transport
EXW50_RS26070	COG0839	Belongs to the complex I subunit 6 family
EXW50_RS26080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW50_RS26085	COG0649	NAD binding
EXW50_RS26090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW50_RS26095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW50_RS26100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW50_RS26105	COG5001	Diguanylate cyclase
EXW50_RS26105	COG3300	MHYT domain
EXW50_RS26120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW50_RS26125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW50_RS26130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW50_RS26135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW50_RS26140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW50_RS26145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW50_RS26155	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW50_RS26180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW50_RS26190	COG0698	ribose 5-phosphate isomerase
EXW50_RS26200	COG2190	(PTS) system
EXW50_RS26205	COG2259	Doxx family
EXW50_RS26210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW50_RS26220	COG1971	Probably functions as a manganese efflux pump
EXW50_RS26225	COG0009	L-threonylcarbamoyladenylate synthase
EXW50_RS26240	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW50_RS26245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW50_RS26250	COG1435	thymidine kinase activity
EXW50_RS26260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW50_RS26265	COG1494	fructose-1,6-bisphosphatase
EXW50_RS26285	COG4821	SIS domain
EXW50_RS26290	COG0504	CTP synthase activity
EXW50_RS26295	COG3343	RNA polymerase activity
EXW50_RS26305	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS26310	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS26315	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW50_RS26320	COG0183	Belongs to the thiolase family
EXW50_RS26325	COG0247	lactate metabolic process
EXW50_RS26325	COG2181	nitrate reductase activity
EXW50_RS26330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW50_RS26335	COG4294	response to UV
EXW50_RS26340	COG3300	MHYT domain
EXW50_RS26340	COG5001	Diguanylate cyclase
EXW50_RS26360	COG2197	response regulator
EXW50_RS26365	COG4585	Histidine kinase
EXW50_RS26370	COG0842	Transport permease protein
EXW50_RS26375	COG1131	(ABC) transporter
EXW50_RS26380	COG0024	Methionine aminopeptidase
EXW50_RS26390	COG2234	aminopeptidase activity
EXW50_RS26405	COG4506	Protein conserved in bacteria
EXW50_RS26410	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW50_RS26425	COG0010	Belongs to the arginase family
EXW50_RS26430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW50_RS26435	COG2814	Major facilitator Superfamily
EXW50_RS26440	COG0789	Transcriptional regulator
EXW50_RS26445	COG0584	glycerophosphoryl diester phosphodiesterase
EXW50_RS26450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW50_RS26460	COG1994	Peptidase M50
EXW50_RS26470	COG1078	dGTPase activity
EXW50_RS26475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW50_RS26480	COG1120	ATPase activity
EXW50_RS26485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS26490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW50_RS26495	COG4844	belongs to the
EXW50_RS26515	COG0280	phosphate acetyltransferase
EXW50_RS26520	COG3253	May function as heme-dependent peroxidase
EXW50_RS26530	COG3773	Cell wall hydrolase
EXW50_RS26540	COG2363	Small membrane protein
EXW50_RS26555	COG2233	PERMEase
EXW50_RS26560	COG0561	phosphatase activity
EXW50_RS26565	COG2814	Major facilitator Superfamily
EXW50_RS26570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW50_RS26575	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW50_RS26580	COG1131	(ABC) transporter
EXW50_RS26585	COG2755	lipolytic protein G-D-S-L family
EXW50_RS26590	COG1609	Transcriptional regulator
EXW50_RS26600	COG0460	homoserine dehydrogenase
EXW50_RS26605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW50_RS26610	COG2873	o-acetylhomoserine
EXW50_RS26625	COG2197	response regulator
EXW50_RS26630	COG4585	Histidine kinase
EXW50_RS26630	COG2203	Gaf domain
EXW50_RS26635	COG0351	phosphomethylpyrimidine kinase
EXW50_RS26640	COG3706	GGDEF domain
EXW50_RS26645	COG2879	small protein
EXW50_RS26650	COG1966	Carbon starvation protein
EXW50_RS26655	COG3279	Response regulator of the LytR AlgR family
EXW50_RS26660	COG0477	Major facilitator Superfamily
EXW50_RS26685	COG0840	transmembrane signaling receptor activity
EXW50_RS26695	COG1607	acyl-coa hydrolase
EXW50_RS26705	COG1216	Glycosyl transferase, family 2
EXW50_RS26710	COG0488	(ABC) transporter
EXW50_RS26725	COG0463	Glycosyl transferase, family 2
EXW50_RS26730	COG1309	transcriptional regulator
EXW50_RS26735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW50_RS26740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW50_RS26740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW50_RS26745	COG0628	permease
EXW50_RS26755	COG1380	Effector of murein hydrolase LrgA
EXW50_RS26760	COG3279	Response regulator of the LytR AlgR family
EXW50_RS26765	COG3275	phosphorelay sensor kinase activity
EXW50_RS26770	COG2814	Major facilitator Superfamily
EXW50_RS26775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW50_RS26780	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW50_RS26785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW50_RS26835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW50_RS26840	COG1272	protein, Hemolysin III
EXW50_RS26870	COG1164	Oligoendopeptidase f
EXW50_RS26880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW50_RS26890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW50_RS26895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW50_RS26900	COG4853	Protein conserved in bacteria
EXW50_RS26910	COG5002	protein histidine kinase activity
EXW50_RS26915	COG0745	RESPONSE REGULATOR receiver
EXW50_RS26945	COG0305	Participates in initiation and elongation during chromosome replication
EXW50_RS26950	COG0359	binds to the 23S rRNA
EXW50_RS26955	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW50_RS26960	COG4241	membrane
EXW50_RS26970	COG0629	single-stranded DNA binding
EXW50_RS26975	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW50_RS26980	COG0012	GTP binding
EXW50_RS26985	COG4481	Protein conserved in bacteria
EXW50_RS26990	COG0668	transmembrane transport
EXW50_RS27000	COG1475	DNA binding
EXW50_RS27005	COG1192	Involved in chromosome partitioning
EXW50_RS27010	COG1475	DNA binding
EXW50_RS27015	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW50_RS27020	COG0445	tRNA wobble uridine modification
EXW50_RS27025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW50_RS27030	COG1847	R3H domain protein
EXW50_RS27035	COG0706	membrane insertase activity
EXW50_RS27040	COG0594	ribonuclease P activity
EXW50_RS27045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW50_RS27060	COG5002	protein histidine kinase activity
EXW50_RS27090	COG0778	Nitroreductase
EXW50_RS27110	COG0384	phenazine biosynthesis protein PhzF
EXW50_RS27115	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EXW50_RS27135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW50_RS27150	COG1674	ftsk spoiiie
EXW50_RS27265	COG0367	asparagine synthase
EXW50_RS27430	COG1396	sequence-specific DNA binding
EXW50_RS27490	COG0463	Glycosyl transferase, family 2
EXW50_RS27495	COG0463	Glycosyl transferase, family 2
EXW50_RS27500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW50_RS27505	COG1086	Polysaccharide biosynthesis protein
EXW50_RS27510	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW50_RS27515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW50_RS27520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW50_RS27535	COG2089	acid synthase
EXW50_RS27540	COG4641	Protein conserved in bacteria
EXW50_RS27580	COG2720	vancomycin resistance protein
EXW50_RS27610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW50_RS27610	COG2755	lipolytic protein G-D-S-L family
EXW50_RS27635	COG0756	dUTP diphosphatase activity
EXW50_RS27685	COG2002	toxin-antitoxin pair type II binding
EXW50_RS27695	COG1923	regulation of RNA biosynthetic process
EXW50_RS27725	COG2814	Major facilitator Superfamily
EXW50_RS27750	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW50_RS27760	COG2002	toxin-antitoxin pair type II binding
EXW50_RS27800	COG0582	viral genome integration into host DNA
EXW50_RS27830	COG1696	Membrane protein involved in D-alanine export
EXW50_RS27840	COG2814	Major facilitator Superfamily
EXW50_RS27860	COG3344	reverse transcriptase
EXW50_RS27895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW50_RS27920	COG0791	NLP P60 protein
EXW50_RS27920	COG3103	Sh3 type 3 domain protein
EXW50_RS27920	COG1388	LysM domain
EXW50_RS27935	COG4974	Belongs to the 'phage' integrase family
EXW50_RS27970	COG0083	homoserine kinase activity
EXW50_RS28005	COG0840	transmembrane signaling receptor activity
EXW50_RS28030	COG2267	carboxylic ester hydrolase activity
EXW50_RS28035	COG1285	pathogenesis
EXW50_RS28040	COG0833	amino acid
EXW50_RS28065	COG0745	RESPONSE REGULATOR receiver
EXW50_RS28090	COG3344	reverse transcriptase
EXW50_RS28105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS28115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXW50_RS28120	COG5002	protein histidine kinase activity
EXW50_RS28125	COG0745	RESPONSE REGULATOR receiver
EXW50_RS28130	COG4990	cell redox homeostasis
EXW50_RS28140	COG0768	penicillin binding
EXW50_RS28145	COG0583	DNA-binding transcription factor activity
EXW50_RS28155	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW50_RS28220	COG2423	ornithine cyclodeaminase activity
EXW50_RS28230	COG2175	clavaminate synthase activity
EXW50_RS28235	COG0137	argininosuccinate synthase activity
EXW50_RS28250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW50_RS28255	COG0251	oxidation-reduction process
EXW50_RS28265	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW50_RS28270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW50_RS28275	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS28300	COG0556	nucleotide-excision repair
EXW50_RS28305	COG0039	L-malate dehydrogenase activity
EXW50_RS28325	COG0436	Aminotransferase
EXW50_RS28365	COG0492	ferredoxin-NADP+ reductase activity
EXW50_RS28380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EXW50_RS28380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW50_RS28390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW50_RS28395	COG1960	acyl-CoA dehydrogenase activity
EXW50_RS28410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW50_RS28420	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EXW50_RS28450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW50_RS28460	COG0438	transferase activity, transferring glycosyl groups
EXW50_RS28465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW50_RS28470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EXW50_RS28485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW50_RS28495	COG1131	(ABC) transporter
EXW50_RS28510	COG2378	regulation of single-species biofilm formation
EXW50_RS28550	COG2002	toxin-antitoxin pair type II binding
EXW50_RS28610	COG2814	Major facilitator Superfamily
EXW50_RS28615	COG0583	DNA-binding transcription factor activity
EXW50_RS28695	COG2357	RelA SpoT domain protein
EXW50_RS28700	COG2814	Major facilitator Superfamily
EXW50_RS28710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW50_RS28810	COG2814	Major facilitator Superfamily
EXW50_RS28820	COG3344	reverse transcriptase
EXW50_RS28850	COG1725	Transcriptional regulator
EXW50_RS28855	COG1131	(ABC) transporter
EXW50_RS28890	COG1329	Transcriptional regulator
EXW50_RS28905	COG1923	regulation of RNA biosynthetic process
EXW50_RS28925	COG0582	viral genome integration into host DNA
EXW50_RS28945	COG1695	Transcriptional regulator
EXW50_RS29025	COG0791	NLP P60 protein
EXW50_RS29025	COG3883	PFAM NLP P60 protein
EXW50_RS29105	COG1396	sequence-specific DNA binding
EXW50_RS29140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW50_RS29145	COG4974	Belongs to the 'phage' integrase family
EXW50_RS29150	COG0024	Methionine aminopeptidase
EXW50_RS29190	COG2814	Major facilitator Superfamily
EXW50_RS29410	COG2076	Multidrug Resistance protein