locus-tag	class	description
EXW44_RS00050	COG2205	protein histidine kinase activity
EXW44_RS00055	COG0745	RESPONSE REGULATOR receiver
EXW44_RS00075	COG0697	spore germination
EXW44_RS00100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW44_RS00105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW44_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW44_RS00115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW44_RS00120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW44_RS00125	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW44_RS00130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW44_RS00135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW44_RS00140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW44_RS00145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW44_RS00150	COG0138	bifunctional purine biosynthesis protein purh
EXW44_RS00155	COG0151	Belongs to the GarS family
EXW44_RS00175	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW44_RS00180	COG0210	DNA helicase
EXW44_RS00185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW44_RS00190	COG4851	CamS sex pheromone cAM373 precursor
EXW44_RS00200	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS00205	COG1335	isochorismatase
EXW44_RS00215	COG2011	ABC-type metal ion transport system permease component
EXW44_RS00220	COG1464	Belongs to the NlpA lipoprotein family
EXW44_RS00235	COG0003	Pfam Anion-transporting ATPase
EXW44_RS00240	COG1846	Transcriptional regulator
EXW44_RS00245	COG4682	membrane
EXW44_RS00255	COG0154	amidase activity
EXW44_RS00260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW44_RS00265	COG1597	lipid kinase activity
EXW44_RS00270	COG0546	phosphoglycolate phosphatase activity
EXW44_RS00275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS00290	COG2076	Multidrug Resistance protein
EXW44_RS00295	COG2309	aminopeptidase activity
EXW44_RS00310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS00320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW44_RS00325	COG5002	protein histidine kinase activity
EXW44_RS00330	COG4807	Protein conserved in bacteria
EXW44_RS00355	COG1757	Na H antiporter
EXW44_RS00360	COG1473	amidohydrolase
EXW44_RS00375	COG0450	alkyl hydroperoxide reductase
EXW44_RS00385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW44_RS00395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS00400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS00405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS00410	COG0492	ferredoxin-NADP+ reductase activity
EXW44_RS00420	COG0166	Belongs to the GPI family
EXW44_RS00445	COG5002	protein histidine kinase activity
EXW44_RS00465	COG3541	Predicted nucleotidyltransferase
EXW44_RS00470	COG2814	Major facilitator Superfamily
EXW44_RS00475	COG0723	plastoquinol--plastocyanin reductase activity
EXW44_RS00475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW44_RS00485	COG0765	amino acid transport
EXW44_RS00490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW44_RS00500	COG3290	protein histidine kinase activity
EXW44_RS00500	COG0840	transmembrane signaling receptor activity
EXW44_RS00525	COG0549	Belongs to the carbamate kinase family
EXW44_RS00540	COG0277	FAD linked oxidase domain protein
EXW44_RS00545	COG0366	Alpha amylase catalytic
EXW44_RS00550	COG2190	(PTS) system
EXW44_RS00550	COG1263	PTS System
EXW44_RS00550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS00570	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW44_RS00575	COG0352	thiamine-phosphate diphosphorylase activity
EXW44_RS00580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW44_RS00595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW44_RS00600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW44_RS00605	COG1116	anion transmembrane transporter activity
EXW44_RS00610	COG0488	(ABC) transporter
EXW44_RS00655	COG2270	Major facilitator Superfamily
EXW44_RS00685	COG2310	stress, protein
EXW44_RS00690	COG2310	stress, protein
EXW44_RS00695	COG2310	stress, protein
EXW44_RS00700	COG0861	Integral membrane protein TerC family
EXW44_RS00710	COG3853	Toxic anion resistance protein (TelA)
EXW44_RS00720	COG4840	Belongs to the UPF0435 family
EXW44_RS00725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW44_RS00735	COG1295	ribonuclease BN
EXW44_RS00740	COG2217	Heavy metal translocating P-type atpase
EXW44_RS00745	COG0697	spore germination
EXW44_RS00765	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS00780	COG3871	stress protein (general stress protein 26)
EXW44_RS00785	COG0387	Pfam Sodium calcium exchanger
EXW44_RS00795	COG0535	radical SAM domain protein
EXW44_RS00815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW44_RS00835	COG3829	transcription factor binding
EXW44_RS00845	COG0833	amino acid
EXW44_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW44_RS00870	COG2066	Belongs to the glutaminase family
EXW44_RS00875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS00875	COG1263	PTS System
EXW44_RS00880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS00895	COG1216	Glycosyl transferase, family 2
EXW44_RS00905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW44_RS00905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW44_RS00910	COG0463	Glycosyl transferase, family 2
EXW44_RS00925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW44_RS00930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW44_RS00945	COG1228	amidohydrolase
EXW44_RS00950	COG1090	epimerase
EXW44_RS00955	COG2137	regulation of response to DNA damage stimulus
EXW44_RS00980	COG1988	membrane-bound metal-dependent
EXW44_RS00985	COG1194	a g-specific adenine glycosylase
EXW44_RS01005	COG3557	Belongs to the UPF0374 family
EXW44_RS01010	COG1132	(ABC) transporter
EXW44_RS01015	COG4129	membrane
EXW44_RS01020	COG0067	glutamate synthase
EXW44_RS01020	COG0069	glutamate synthase activity
EXW44_RS01020	COG0070	glutamate synthase
EXW44_RS01025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW44_RS01030	COG4555	ABC transporter
EXW44_RS01050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW44_RS01055	COG0735	belongs to the Fur family
EXW44_RS01175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW44_RS01180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW44_RS01200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW44_RS01210	COG2766	serine protein kinase
EXW44_RS01215	COG2718	Belongs to the UPF0229 family
EXW44_RS01230	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW44_RS01235	COG2268	Band 7 protein
EXW44_RS01245	COG3290	protein histidine kinase activity
EXW44_RS01250	COG4565	transcriptional regulatory protein
EXW44_RS01255	COG2851	Citrate transporter
EXW44_RS01280	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW44_RS01285	COG3842	ATPase activity
EXW44_RS01290	COG1175	transmembrane transport
EXW44_RS01295	COG0395	ABC-type sugar transport system, permease component
EXW44_RS01305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW44_RS01310	COG0745	RESPONSE REGULATOR receiver
EXW44_RS01315	COG5002	protein histidine kinase activity
EXW44_RS01325	COG4990	cell redox homeostasis
EXW44_RS01335	COG3290	protein histidine kinase activity
EXW44_RS01340	COG4565	transcriptional regulatory protein
EXW44_RS01345	COG3493	citrate carrier protein
EXW44_RS01350	COG0281	malic enzyme
EXW44_RS01360	COG0697	spore germination
EXW44_RS01365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS01375	COG5002	protein histidine kinase activity
EXW44_RS01380	COG0745	RESPONSE REGULATOR receiver
EXW44_RS01385	COG0456	acetyltransferase
EXW44_RS01390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW44_RS01395	COG3383	formate dehydrogenase (NAD+) activity
EXW44_RS01400	COG2427	Protein of unknown function (DUF1641)
EXW44_RS01415	COG0531	amino acid
EXW44_RS01425	COG0640	Transcriptional regulator
EXW44_RS01430	COG2217	Heavy metal translocating P-type atpase
EXW44_RS01435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW44_RS01450	COG3227	Zinc metalloprotease (Elastase)
EXW44_RS01470	COG2720	vancomycin resistance protein
EXW44_RS01475	COG1316	TRANSCRIPTIONal
EXW44_RS01480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS01485	COG0346	lactoylglutathione lyase activity
EXW44_RS01490	COG1253	flavin adenine dinucleotide binding
EXW44_RS01495	COG1027	Aspartate ammonia-lyase
EXW44_RS01500	COG1620	l-lactate permease
EXW44_RS01505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS01520	COG3104	oligopeptide transport
EXW44_RS01525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS01530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS01535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS01550	COG0156	8-amino-7-oxononanoate synthase activity
EXW44_RS01555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW44_RS01565	COG4548	von Willebrand factor, type A
EXW44_RS01570	COG0714	Associated with various cellular activities
EXW44_RS01590	COG0531	amino acid
EXW44_RS01595	COG2188	Transcriptional regulator
EXW44_RS01600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS01600	COG1263	PTS System
EXW44_RS01605	COG0366	Alpha amylase catalytic
EXW44_RS01620	COG0697	spore germination
EXW44_RS01625	COG4585	Histidine kinase
EXW44_RS01630	COG2197	response regulator
EXW44_RS01635	COG1404	Belongs to the peptidase S8 family
EXW44_RS01650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW44_RS01655	COG1115	amino acid carrier protein
EXW44_RS01660	COG1126	abc transporter atp-binding protein
EXW44_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW44_RS01670	COG0765	amino acid transport
EXW44_RS01675	COG0765	amino acid transport
EXW44_RS01680	COG0833	amino acid
EXW44_RS01705	COG2378	regulation of single-species biofilm formation
EXW44_RS01710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW44_RS01715	COG5002	protein histidine kinase activity
EXW44_RS01720	COG0745	RESPONSE REGULATOR receiver
EXW44_RS01730	COG0659	secondary active sulfate transmembrane transporter activity
EXW44_RS01745	COG2271	Major facilitator Superfamily
EXW44_RS01750	COG1846	Transcriptional regulator
EXW44_RS01755	COG0477	Major facilitator Superfamily
EXW44_RS01760	COG1609	Transcriptional regulator
EXW44_RS01765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW44_RS01770	COG1869	D-ribose catabolic process
EXW44_RS01780	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW44_RS01785	COG1879	ABC-type sugar transport system periplasmic component
EXW44_RS01815	COG1063	alcohol dehydrogenase
EXW44_RS01830	COG3568	Endonuclease Exonuclease Phosphatase
EXW44_RS01860	COG0840	transmembrane signaling receptor activity
EXW44_RS01865	COG1388	LysM domain
EXW44_RS01865	COG3584	3D domain protein
EXW44_RS01870	COG1476	TRANSCRIPTIONal
EXW44_RS01890	COG3104	oligopeptide transport
EXW44_RS01895	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS01910	COG1113	amino acid transport
EXW44_RS01915	COG2252	PERMEase
EXW44_RS01930	COG2153	protein acetylation
EXW44_RS01940	COG0569	domain protein
EXW44_RS01940	COG0475	glutathione-regulated potassium exporter activity
EXW44_RS01950	COG1845	cytochrome c oxidase, subunit III
EXW44_RS01955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW44_RS01965	COG0833	amino acid
EXW44_RS01970	COG4990	cell redox homeostasis
EXW44_RS01985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW44_RS01990	COG0697	spore germination
EXW44_RS01995	COG0531	amino acid
EXW44_RS02005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW44_RS02010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW44_RS02020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW44_RS02025	COG0573	inorganic phosphate transmembrane transporter activity
EXW44_RS02030	COG0581	inorganic phosphate transmembrane transporter activity
EXW44_RS02040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW44_RS02160	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW44_RS02175	COG4991	sh3 domain protein
EXW44_RS02175	COG3103	Sh3 type 3 domain protein
EXW44_RS02175	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS02180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW44_RS02185	COG1116	anion transmembrane transporter activity
EXW44_RS02190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW44_RS02195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW44_RS02200	COG0352	thiamine-phosphate diphosphorylase activity
EXW44_RS02205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW44_RS02210	COG2104	thiamine diphosphate biosynthetic process
EXW44_RS02215	COG2022	thiamine diphosphate biosynthetic process
EXW44_RS02220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW44_RS02225	COG0351	phosphomethylpyrimidine kinase
EXW44_RS02250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW44_RS02255	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW44_RS02260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW44_RS02265	COG2205	protein histidine kinase activity
EXW44_RS02270	COG2814	Major facilitator Superfamily
EXW44_RS02275	COG1846	Transcriptional regulator
EXW44_RS02295	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW44_RS02300	COG1129	ABC transporter
EXW44_RS02305	COG1879	ABC-type sugar transport system periplasmic component
EXW44_RS02310	COG2252	PERMEase
EXW44_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS02330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW44_RS02335	COG1621	beta-fructofuranosidase activity
EXW44_RS02340	COG1263	PTS System
EXW44_RS02340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS02345	COG1609	Transcriptional regulator
EXW44_RS02395	COG0778	Nitroreductase
EXW44_RS02400	COG2719	SpoVR family
EXW44_RS02425	COG1937	Protein conserved in bacteria
EXW44_RS02430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS02430	COG0425	Belongs to the sulfur carrier protein TusA family
EXW44_RS02435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS02440	COG0425	Belongs to the sulfur carrier protein TusA family
EXW44_RS02445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS02445	COG0425	Belongs to the sulfur carrier protein TusA family
EXW44_RS02450	COG2210	Belongs to the sulfur carrier protein TusA family
EXW44_RS02455	COG0730	response to heat
EXW44_RS02465	COG1316	TRANSCRIPTIONal
EXW44_RS02470	COG0604	alcohol dehydrogenase
EXW44_RS02475	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW44_RS02480	COG0604	alcohol dehydrogenase
EXW44_RS02485	COG2814	Major facilitator Superfamily
EXW44_RS02495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS02495	COG3711	transcriptional antiterminator
EXW44_RS02500	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW44_RS02505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW44_RS02530	COG3584	3D domain protein
EXW44_RS02530	COG1388	LysM domain
EXW44_RS02535	COG0577	efflux transmembrane transporter activity
EXW44_RS02540	COG1136	(ABC) transporter
EXW44_RS02550	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW44_RS02565	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS02570	COG3546	catalase activity
EXW44_RS02600	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS02630	COG0531	amino acid
EXW44_RS02635	COG0475	glutathione-regulated potassium exporter activity
EXW44_RS02645	COG1737	Transcriptional regulator
EXW44_RS02650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW44_RS02655	COG1263	PTS System
EXW44_RS02655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS02665	COG2259	Doxx family
EXW44_RS02685	COG0697	spore germination
EXW44_RS02690	COG1522	sequence-specific DNA binding
EXW44_RS02700	COG0300	oxidoreductase activity
EXW44_RS02715	COG2076	Multidrug Resistance protein
EXW44_RS02720	COG1309	transcriptional regulator
EXW44_RS02725	COG2814	Major facilitator Superfamily
EXW44_RS02730	COG1733	regulation of RNA biosynthetic process
EXW44_RS02740	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW44_RS02750	COG4533	DNA binding
EXW44_RS02755	COG2211	Major facilitator Superfamily
EXW44_RS02770	COG0531	amino acid
EXW44_RS02775	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS02780	COG1132	(ABC) transporter
EXW44_RS02785	COG1132	(ABC) transporter
EXW44_RS02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW44_RS02795	COG0765	amino acid transport
EXW44_RS02800	COG1126	abc transporter atp-binding protein
EXW44_RS02815	COG0189	ligase activity
EXW44_RS02825	COG4399	Belongs to the UPF0754 family
EXW44_RS02830	COG3679	Belongs to the UPF0342 family
EXW44_RS02845	COG0028	Belongs to the TPP enzyme family
EXW44_RS02850	COG3527	Alpha-acetolactate decarboxylase
EXW44_RS02855	COG0463	Glycosyl transferase, family 2
EXW44_RS02860	COG1216	Glycosyl transferase, family 2
EXW44_RS02865	COG2094	Belongs to the DNA glycosylase MPG family
EXW44_RS02870	COG0561	phosphatase activity
EXW44_RS02880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW44_RS02885	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS02895	COG0659	secondary active sulfate transmembrane transporter activity
EXW44_RS02910	COG0653	protein targeting
EXW44_RS02915	COG2244	polysaccharide biosynthetic process
EXW44_RS02925	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS02945	COG1696	Membrane protein involved in D-alanine export
EXW44_RS02960	COG1024	Enoyl-CoA hydratase
EXW44_RS02975	COG1363	Peptidase, m42
EXW44_RS02990	COG2318	DinB family
EXW44_RS03010	COG0579	oxidoreductase
EXW44_RS03045	COG0601	transmembrane transport
EXW44_RS03050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW44_RS03055	COG0444	Belongs to the ABC transporter superfamily
EXW44_RS03060	COG4608	Belongs to the ABC transporter superfamily
EXW44_RS03160	COG0582	viral genome integration into host DNA
EXW44_RS03260	COG0477	Major facilitator Superfamily
EXW44_RS03265	COG3290	protein histidine kinase activity
EXW44_RS03270	COG4565	transcriptional regulatory protein
EXW44_RS03275	COG3181	Tripartite tricarboxylate transporter family receptor
EXW44_RS03280	COG0494	nUDIX hydrolase
EXW44_RS03285	COG0513	Belongs to the DEAD box helicase family
EXW44_RS03305	COG0326	Molecular chaperone. Has ATPase activity
EXW44_RS03340	COG1475	DNA binding
EXW44_RS03350	COG0305	Participates in initiation and elongation during chromosome replication
EXW44_RS03380	COG0477	Major facilitator Superfamily
EXW44_RS03465	COG2814	Major facilitator Superfamily
EXW44_RS03470	COG0640	Transcriptional regulator
EXW44_RS03490	COG2376	Dihydroxyacetone kinase
EXW44_RS03500	COG2376	Dihydroxyacetone kinase
EXW44_RS03515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW44_RS03530	COG1335	isochorismatase
EXW44_RS03555	COG0076	glutamate decarboxylase activity
EXW44_RS03580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW44_RS03585	COG1278	Cold shock
EXW44_RS03595	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EXW44_RS03595	COG3266	domain, Protein
EXW44_RS03595	COG4932	domain protein
EXW44_RS03600	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS03600	COG4085	toxin activity
EXW44_RS03600	COG1525	nuclease
EXW44_RS03610	COG0582	viral genome integration into host DNA
EXW44_RS03625	COG2378	regulation of single-species biofilm formation
EXW44_RS03630	COG2318	DinB family
EXW44_RS03635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EXW44_RS03635	COG3266	domain, Protein
EXW44_RS03635	COG4932	domain protein
EXW44_RS03645	COG0825	malonyl-CoA metabolic process
EXW44_RS03665	COG3237	CsbD-like
EXW44_RS03685	COG2172	sigma factor antagonist activity
EXW44_RS03690	COG1191	sigma factor activity
EXW44_RS03700	COG2208	phosphoserine phosphatase activity
EXW44_RS03705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW44_RS03710	COG2205	protein histidine kinase activity
EXW44_RS03710	COG5002	protein histidine kinase activity
EXW44_RS03710	COG0784	Response regulator, receiver
EXW44_RS03755	COG2807	transmembrane transport
EXW44_RS03760	COG2186	Transcriptional regulator
EXW44_RS03765	COG4585	Histidine kinase
EXW44_RS03770	COG2197	response regulator
EXW44_RS03800	COG0420	3'-5' exonuclease activity
EXW44_RS03805	COG4717	serine-type aminopeptidase activity
EXW44_RS03810	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW44_RS03820	COG0346	lactoylglutathione lyase activity
EXW44_RS03825	COG0346	lactoylglutathione lyase activity
EXW44_RS03830	COG0457	Tetratricopeptide repeat
EXW44_RS03840	COG2267	carboxylic ester hydrolase activity
EXW44_RS03865	COG3620	sequence-specific DNA binding
EXW44_RS03870	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW44_RS03875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW44_RS03880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW44_RS03885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW44_RS03890	COG1595	DNA-templated transcription, initiation
EXW44_RS03905	COG3973	AAA domain
EXW44_RS03910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW44_RS03925	COG1846	Transcriptional regulator
EXW44_RS03935	COG0537	adenosine 5'-monophosphoramidase activity
EXW44_RS03940	COG1131	(ABC) transporter
EXW44_RS03945	COG4473	ABC transporter
EXW44_RS03965	COG2222	sugar isomerase
EXW44_RS03975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS03980	COG3715	PTS system
EXW44_RS03985	COG3716	PTS system mannose fructose sorbose family IID component
EXW44_RS03990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS03990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS04005	COG3684	Belongs to the aldolase LacD family
EXW44_RS04010	COG2188	Transcriptional regulator
EXW44_RS04015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS04030	COG0247	lactate metabolic process
EXW44_RS04035	COG1139	Iron-sulfur cluster binding protein
EXW44_RS04040	COG1556	Lactate utilization protein
EXW44_RS04060	COG3402	PFAM membrane-flanked domain
EXW44_RS04065	COG3428	Bacterial PH domain
EXW44_RS04095	COG3402	PFAM membrane-flanked domain
EXW44_RS04100	COG3428	Bacterial PH domain
EXW44_RS04105	COG2329	Antibiotic biosynthesis monooxygenase
EXW44_RS04110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW44_RS04115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW44_RS04120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW44_RS04125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW44_RS04150	COG1309	transcriptional regulator
EXW44_RS04155	COG1511	domain protein
EXW44_RS04190	COG2378	regulation of single-species biofilm formation
EXW44_RS04195	COG1609	Transcriptional regulator
EXW44_RS04205	COG1234	tRNA 3'-trailer cleavage
EXW44_RS04210	COG0095	Lipoate-protein ligase
EXW44_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS04235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW44_RS04240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW44_RS04245	COG4208	sulfate ABC transporter
EXW44_RS04260	COG1408	metallophosphoesterase
EXW44_RS04265	COG1078	dGTPase activity
EXW44_RS04280	COG1595	DNA-templated transcription, initiation
EXW44_RS04285	COG3708	Transcriptional regulator
EXW44_RS04285	COG2207	Transcriptional regulator
EXW44_RS04290	COG2205	protein histidine kinase activity
EXW44_RS04295	COG0745	RESPONSE REGULATOR receiver
EXW44_RS04310	COG0501	Belongs to the peptidase M48B family
EXW44_RS04315	COG0697	spore germination
EXW44_RS04340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW44_RS04345	COG2224	Isocitrate lyase
EXW44_RS04355	COG1278	Cold shock
EXW44_RS04365	COG4903	ComK protein
EXW44_RS04370	COG0398	Pfam SNARE associated Golgi protein
EXW44_RS04380	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW44_RS04385	COG1074	ATP-dependent DNA helicase activity
EXW44_RS04435	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW44_RS04460	COG0367	asparagine synthase
EXW44_RS04470	COG0753	catalase activity
EXW44_RS04475	COG0004	ammonium transporteR
EXW44_RS04485	COG1666	GTP binding
EXW44_RS04490	COG2996	Protein conserved in bacteria
EXW44_RS04495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW44_RS04505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS04520	COG0561	phosphatase activity
EXW44_RS04540	COG2267	carboxylic ester hydrolase activity
EXW44_RS04555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW44_RS04560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW44_RS04565	COG5504	Zn-dependent protease
EXW44_RS04575	COG0180	Tryptophanyl-tRNA synthetase
EXW44_RS04585	COG4166	transmembrane transport
EXW44_RS04590	COG0601	transmembrane transport
EXW44_RS04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW44_RS04600	COG0444	Belongs to the ABC transporter superfamily
EXW44_RS04605	COG4608	Belongs to the ABC transporter superfamily
EXW44_RS04610	COG0534	Mate efflux family protein
EXW44_RS04615	COG4166	transmembrane transport
EXW44_RS04630	COG0861	Integral membrane protein TerC family
EXW44_RS04635	COG4862	establishment of competence for transformation
EXW44_RS04640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW44_RS04650	COG1164	Oligoendopeptidase f
EXW44_RS04665	COG2346	COG2346, Truncated hemoglobins
EXW44_RS04670	COG4116	CYTH
EXW44_RS04680	COG2357	RelA SpoT domain protein
EXW44_RS04690	COG0564	pseudouridine synthase activity
EXW44_RS04700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW44_RS04705	COG0772	Belongs to the SEDS family
EXW44_RS04710	COG1216	Glycosyl transferase, family 2
EXW44_RS04730	COG0463	Glycosyl transferase, family 2
EXW44_RS04730	COG0457	Tetratricopeptide repeat
EXW44_RS04750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW44_RS04765	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW44_RS04810	COG2153	protein acetylation
EXW44_RS04815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW44_RS04820	COG2382	esterase
EXW44_RS04845	COG5492	domain, Protein
EXW44_RS04850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW44_RS04860	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW44_RS04860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW44_RS04865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW44_RS04870	COG0134	indole-3-glycerol-phosphate synthase activity
EXW44_RS04875	COG0135	phosphoribosylanthranilate isomerase activity
EXW44_RS04880	COG0133	tryptophan synthase activity
EXW44_RS04885	COG0159	tryptophan synthase activity
EXW44_RS04895	COG1620	l-lactate permease
EXW44_RS04900	COG5634	Uncharacterized conserved protein (DUF2278)
EXW44_RS04935	COG2226	methyltransferase
EXW44_RS04955	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW44_RS04960	COG0567	Dehydrogenase, E1 component
EXW44_RS04965	COG1476	TRANSCRIPTIONal
EXW44_RS05020	COG1686	Belongs to the peptidase S11 family
EXW44_RS05025	COG0681	Belongs to the peptidase S26 family
EXW44_RS05060	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS05070	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW44_RS05075	COG1177	transmembrane transport
EXW44_RS05080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW44_RS05090	COG2409	Drug exporters of the RND superfamily
EXW44_RS05100	COG0564	pseudouridine synthase activity
EXW44_RS05110	COG2340	Cysteine-rich secretory protein family
EXW44_RS05115	COG0247	lactate metabolic process
EXW44_RS05120	COG0277	FAD linked oxidase domain protein
EXW44_RS05125	COG3835	regulator
EXW44_RS05135	COG0745	RESPONSE REGULATOR receiver
EXW44_RS05140	COG5002	protein histidine kinase activity
EXW44_RS05145	COG2186	Transcriptional regulator
EXW44_RS05150	COG0247	lactate metabolic process
EXW44_RS05155	COG1139	Iron-sulfur cluster binding protein
EXW44_RS05160	COG1556	Lactate utilization protein
EXW44_RS05165	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW44_RS05175	COG2116	formate transmembrane transporter activity
EXW44_RS05180	COG0861	Integral membrane protein TerC family
EXW44_RS05185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW44_RS05195	COG2030	dehydratase
EXW44_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS05220	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW44_RS05230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW44_RS05245	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW44_RS05250	COG3842	ATPase activity
EXW44_RS05260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW44_RS05265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW44_RS05275	COG1349	DNA-binding transcription factor activity
EXW44_RS05285	COG0235	Class ii aldolase
EXW44_RS05295	COG2861	carbohydrate metabolic process
EXW44_RS05305	COG3852	Histidine kinase
EXW44_RS05310	COG1846	Transcriptional regulator
EXW44_RS05320	COG2318	DinB family
EXW44_RS05325	COG5002	protein histidine kinase activity
EXW44_RS05330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW44_RS05335	COG0720	synthase
EXW44_RS05345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW44_RS05350	COG4873	Protein conserved in bacteria
EXW44_RS05365	COG0456	acetyltransferase
EXW44_RS05380	COG1780	Probably involved in ribonucleotide reductase function
EXW44_RS05395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW44_RS05400	COG0531	amino acid
EXW44_RS05405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW44_RS05420	COG2204	response regulator
EXW44_RS05430	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS05440	COG1725	Transcriptional regulator
EXW44_RS05445	COG1131	(ABC) transporter
EXW44_RS05455	COG1131	(ABC) transporter
EXW44_RS05460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW44_RS05465	COG1266	CAAX protease self-immunity
EXW44_RS05475	COG1522	sequence-specific DNA binding
EXW44_RS05485	COG1335	isochorismatase
EXW44_RS05495	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW44_RS05500	COG2070	2-Nitropropane dioxygenase
EXW44_RS05505	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW44_RS05510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW44_RS05515	COG1696	Membrane protein involved in D-alanine export
EXW44_RS05540	COG0716	FMN binding
EXW44_RS05600	COG1846	Transcriptional regulator
EXW44_RS05610	COG1301	dicarboxylic acid transport
EXW44_RS05615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW44_RS05625	COG3874	Sporulation protein YtfJ
EXW44_RS05645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS05650	COG0028	Belongs to the TPP enzyme family
EXW44_RS05655	COG0440	acetolactate synthase activity
EXW44_RS05665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW44_RS05675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW44_RS05685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW44_RS05690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW44_RS05700	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW44_RS05705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW44_RS05710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW44_RS05715	COG0107	imidazoleglycerol-phosphate synthase activity
EXW44_RS05725	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW44_RS05730	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW44_RS05745	COG1183	phosphatidylcholine synthase activity
EXW44_RS05750	COG1368	sulfuric ester hydrolase activity
EXW44_RS05760	COG0019	diaminopimelate decarboxylase activity
EXW44_RS05770	COG0175	sulfate reduction
EXW44_RS05775	COG2046	Belongs to the sulfate adenylyltransferase family
EXW44_RS05780	COG0529	Catalyzes the synthesis of activated sulfate
EXW44_RS05785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW44_RS05805	COG1648	precorrin-2 dehydrogenase activity
EXW44_RS05810	COG0733	neurotransmitter:sodium symporter activity
EXW44_RS05835	COG1757	Na H antiporter
EXW44_RS05850	COG4758	membrane
EXW44_RS05855	COG4585	Histidine kinase
EXW44_RS05860	COG2197	response regulator
EXW44_RS05870	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS05880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW44_RS05920	COG0730	response to heat
EXW44_RS05925	COG0306	phosphate transporter
EXW44_RS05930	COG1392	Phosphate transport regulator
EXW44_RS05935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW44_RS05950	COG3852	Histidine kinase
EXW44_RS05955	COG1801	Protein of unknown function DUF72
EXW44_RS05970	COG0582	viral genome integration into host DNA
EXW44_RS05975	COG5002	protein histidine kinase activity
EXW44_RS05990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW44_RS05990	COG0392	lysyltransferase activity
EXW44_RS06005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW44_RS06010	COG1686	Belongs to the peptidase S11 family
EXW44_RS06015	COG2715	membrane protein required for spore maturation
EXW44_RS06020	COG0700	Nucleoside recognition
EXW44_RS06025	COG1187	pseudouridine synthase activity
EXW44_RS06035	COG1333	cytochrome c biogenesis protein
EXW44_RS06040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW44_RS06045	COG0745	RESPONSE REGULATOR receiver
EXW44_RS06050	COG5002	protein histidine kinase activity
EXW44_RS06055	COG2096	Adenosyltransferase
EXW44_RS06060	COG4942	peptidase
EXW44_RS06070	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW44_RS06075	COG1141	Ferredoxin
EXW44_RS06080	COG4955	Helix-turn-helix domain
EXW44_RS06085	COG0514	ATP-dependent DNA helicase (RecQ)
EXW44_RS06090	COG1266	CAAX protease self-immunity
EXW44_RS06100	COG1408	metallophosphoesterase
EXW44_RS06115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW44_RS06135	COG0492	ferredoxin-NADP+ reductase activity
EXW44_RS06140	COG0252	asparaginase activity
EXW44_RS06150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW44_RS06160	COG1304	FMN binding
EXW44_RS06190	COG1160	GTP binding
EXW44_RS06195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW44_RS06215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW44_RS06225	COG0302	gtp cyclohydrolase
EXW44_RS06230	COG0142	geranyltranstransferase activity
EXW44_RS06235	COG2226	methyltransferase
EXW44_RS06240	COG0142	geranyltranstransferase activity
EXW44_RS06255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW44_RS06265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW44_RS06270	COG0457	Tetratricopeptide repeat
EXW44_RS06275	COG5582	Belongs to the UPF0302 family
EXW44_RS06290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW44_RS06305	COG4347	Protein of unknown function (DUF1405)
EXW44_RS06320	COG2738	Putative neutral zinc metallopeptidase
EXW44_RS06330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS06335	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW44_RS06340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW44_RS06345	COG1803	Methylglyoxal synthase
EXW44_RS06350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW44_RS06355	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS06360	COG0617	tRNA 3'-terminal CCA addition
EXW44_RS06370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW44_RS06375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW44_RS06385	COG1199	ATP-dependent helicase activity
EXW44_RS06385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW44_RS06405	COG3935	DnaD domain protein
EXW44_RS06410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW44_RS06420	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW44_RS06420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW44_RS06425	COG3331	DNA recombination
EXW44_RS06460	COG4474	Belongs to the UPF0398 family
EXW44_RS06465	COG3599	regulation of cell shape
EXW44_RS06475	COG0116	Belongs to the methyltransferase superfamily
EXW44_RS06485	COG1199	ATP-dependent helicase activity
EXW44_RS06490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW44_RS06500	COG0024	Methionine aminopeptidase
EXW44_RS06510	COG2233	PERMEase
EXW44_RS06515	COG2311	Membrane
EXW44_RS06525	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW44_RS06535	COG0456	acetyltransferase
EXW44_RS06545	COG2897	thiosulfate sulfurtransferase activity
EXW44_RS06585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW44_RS06600	COG0454	-acetyltransferase
EXW44_RS06620	COG0328	RNA-DNA hybrid ribonuclease activity
EXW44_RS06655	COG3403	YqcI/YcgG family
EXW44_RS06660	COG1280	lysine exporter protein (LysE YggA)
EXW44_RS06675	COG3162	membrane
EXW44_RS06680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW44_RS06685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW44_RS06695	COG0475	glutathione-regulated potassium exporter activity
EXW44_RS06700	COG4978	Transcriptional regulator
EXW44_RS06700	COG0789	Transcriptional regulator
EXW44_RS06710	COG2323	membrane
EXW44_RS06715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW44_RS06745	COG2814	Major facilitator Superfamily
EXW44_RS06765	COG1923	regulation of RNA biosynthetic process
EXW44_RS06775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW44_RS06780	COG1360	Flagellar Motor Protein
EXW44_RS06785	COG2201	protein-glutamate methylesterase activity
EXW44_RS06790	COG2198	Histidine kinase
EXW44_RS06790	COG0643	Histidine kinase
EXW44_RS06795	COG1776	CheC inhibitor of MCP methylation
EXW44_RS06795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW44_RS06810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW44_RS06830	COG1256	bacterial-type flagellum assembly
EXW44_RS06835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW44_RS06855	COG1815	bacterial-type flagellum-dependent cell motility
EXW44_RS06860	COG1558	bacterial-type flagellum-dependent cell motility
EXW44_RS06870	COG1766	The M ring may be actively involved in energy transduction
EXW44_RS06875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW44_RS06885	COG1157	protein secretion by the type III secretion system
EXW44_RS06905	COG1749	Flagellar hook protein flgE
EXW44_RS06920	COG0784	Response regulator, receiver
EXW44_RS06920	COG0835	chemotaxis
EXW44_RS06940	COG0861	Integral membrane protein TerC family
EXW44_RS06950	COG3383	formate dehydrogenase (NAD+) activity
EXW44_RS06955	COG2427	Protein of unknown function (DUF1641)
EXW44_RS06960	COG5609	conserved protein (DUF2294)
EXW44_RS06965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW44_RS06975	COG2116	formate transmembrane transporter activity
EXW44_RS06980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW44_RS06985	COG0303	'Molybdopterin
EXW44_RS06990	COG0314	molybdopterin synthase activity
EXW44_RS06995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW44_RS07005	COG0489	protein tyrosine kinase activity
EXW44_RS07010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW44_RS07015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW44_RS07020	COG0741	lytic transglycosylase activity
EXW44_RS07030	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW44_RS07035	COG1776	CheC inhibitor of MCP methylation
EXW44_RS07035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW44_RS07045	COG1338	Plays a role in the flagellum-specific transport system
EXW44_RS07050	COG1987	bacterial-type flagellum assembly
EXW44_RS07060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW44_RS07065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW44_RS07070	COG1419	protein localization to endoplasmic reticulum
EXW44_RS07075	COG4786	Flagellar basal body rod
EXW44_RS07080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW44_RS07110	COG0412	Dienelactone hydrolase
EXW44_RS07115	COG2329	Antibiotic biosynthesis monooxygenase
EXW44_RS07130	COG2814	Major facilitator Superfamily
EXW44_RS07140	COG0583	DNA-binding transcription factor activity
EXW44_RS07145	COG3842	ATPase activity
EXW44_RS07195	COG0406	alpha-ribazole phosphatase activity
EXW44_RS07225	COG0367	asparagine synthase
EXW44_RS07255	COG1802	Transcriptional regulator
EXW44_RS07260	COG0697	spore germination
EXW44_RS07275	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS07275	COG1216	Glycosyl transferase, family 2
EXW44_RS07280	COG1757	Na H antiporter
EXW44_RS07290	COG0277	FAD linked oxidase domain protein
EXW44_RS07310	COG0534	Mate efflux family protein
EXW44_RS07315	COG3340	Belongs to the peptidase S51 family
EXW44_RS07335	COG0785	Cytochrome C biogenesis protein
EXW44_RS07340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS07355	COG3048	D-serine ammonia-lyase activity
EXW44_RS07360	COG2733	membrane
EXW44_RS07395	COG1131	(ABC) transporter
EXW44_RS07410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW44_RS07445	COG0528	UMP kinase activity
EXW44_RS07455	COG1027	Aspartate ammonia-lyase
EXW44_RS07460	COG0281	malic enzyme
EXW44_RS07465	COG4191	Histidine kinase
EXW44_RS07470	COG0784	Response regulator, receiver
EXW44_RS07475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW44_RS07485	COG2502	aspartate--ammonia ligase
EXW44_RS07520	COG1051	belongs to the nudix hydrolase family
EXW44_RS07525	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS07535	COG2814	Major facilitator Superfamily
EXW44_RS07565	COG0477	Major facilitator Superfamily
EXW44_RS07570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW44_RS07580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW44_RS07585	COG2223	nitrite transmembrane transporter activity
EXW44_RS07590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW44_RS07605	COG2244	polysaccharide biosynthetic process
EXW44_RS07610	COG0733	neurotransmitter:sodium symporter activity
EXW44_RS07620	COG5566	PFAM Mor transcription activator
EXW44_RS07625	COG2323	membrane
EXW44_RS07640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW44_RS07650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS07655	COG0028	Belongs to the TPP enzyme family
EXW44_RS07670	COG0129	dihydroxy-acid dehydratase activity
EXW44_RS07675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW44_RS07700	COG2814	Major facilitator Superfamily
EXW44_RS07705	COG3384	dioxygenase
EXW44_RS07730	COG4166	transmembrane transport
EXW44_RS07760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS07780	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW44_RS07785	COG1054	Belongs to the UPF0176 family
EXW44_RS07795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW44_RS07800	COG0531	amino acid
EXW44_RS07835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW44_RS07850	COG4257	antibiotic catabolic process
EXW44_RS07855	COG2390	Transcriptional regulator
EXW44_RS07865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW44_RS07870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS07875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW44_RS07890	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW44_RS07905	COG0583	DNA-binding transcription factor activity
EXW44_RS07925	COG0006	proline dipeptidase activity
EXW44_RS07930	COG2132	Multicopper oxidase
EXW44_RS07940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW44_RS07960	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS07970	COG4641	Protein conserved in bacteria
EXW44_RS07980	COG1276	copper resistance
EXW44_RS07980	COG2372	response to copper ion
EXW44_RS07985	COG4549	nuclear export factor GLE1
EXW44_RS07995	COG0697	spore germination
EXW44_RS08000	COG0583	DNA-binding transcription factor activity
EXW44_RS08005	COG1959	2 iron, 2 sulfur cluster binding
EXW44_RS08010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW44_RS08015	COG0778	Nitroreductase
EXW44_RS08025	COG0628	permease
EXW44_RS08040	COG1231	oxidoreductase activity
EXW44_RS08045	COG0523	cobalamin synthesis protein
EXW44_RS08055	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS08060	COG2030	dehydratase
EXW44_RS08065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW44_RS08080	COG0411	ABC transporter
EXW44_RS08100	COG0583	DNA-binding transcription factor activity
EXW44_RS08110	COG1942	4-Oxalocrotonate Tautomerase
EXW44_RS08125	COG0346	lactoylglutathione lyase activity
EXW44_RS08135	COG1271	oxidase subunit
EXW44_RS08140	COG1294	oxidase, subunit
EXW44_RS08145	COG4988	ABC transporter
EXW44_RS08150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW44_RS08180	COG1686	Belongs to the peptidase S11 family
EXW44_RS08195	COG0791	NLP P60 protein
EXW44_RS08195	COG1388	LysM domain
EXW44_RS08205	COG1132	(ABC) transporter
EXW44_RS08210	COG0745	RESPONSE REGULATOR receiver
EXW44_RS08215	COG5002	protein histidine kinase activity
EXW44_RS08220	COG0300	oxidoreductase activity
EXW44_RS08225	COG4122	O-methyltransferase activity
EXW44_RS08255	COG0460	homoserine dehydrogenase
EXW44_RS08265	COG0083	homoserine kinase activity
EXW44_RS08280	COG1316	TRANSCRIPTIONal
EXW44_RS08300	COG1285	pathogenesis
EXW44_RS08305	COG1247	-acetyltransferase
EXW44_RS08325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW44_RS08335	COG1082	Xylose isomerase domain protein TIM barrel
EXW44_RS08345	COG2814	Major facilitator Superfamily
EXW44_RS08350	COG1279	arginine transmembrane transporter activity
EXW44_RS08355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS08365	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW44_RS08395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW44_RS08400	COG0577	efflux transmembrane transporter activity
EXW44_RS08405	COG2002	toxin-antitoxin pair type II binding
EXW44_RS08410	COG1404	Belongs to the peptidase S8 family
EXW44_RS08420	COG3842	ATPase activity
EXW44_RS08425	COG2508	Transcriptional regulator
EXW44_RS08435	COG1653	transport
EXW44_RS08440	COG1175	transmembrane transport
EXW44_RS08445	COG0395	ABC-type sugar transport system, permease component
EXW44_RS08450	COG5426	von Willebrand factor, type A
EXW44_RS08460	COG1940	carbohydrate kinase activity
EXW44_RS08465	COG2222	sugar isomerase
EXW44_RS08475	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW44_RS08480	COG3684	Belongs to the aldolase LacD family
EXW44_RS08485	COG0366	Alpha amylase catalytic
EXW44_RS08490	COG0366	Alpha amylase catalytic
EXW44_RS08495	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EXW44_RS08500	COG0640	Transcriptional regulator
EXW44_RS08505	COG0667	Aldo Keto reductase
EXW44_RS08550	COG3949	Membrane
EXW44_RS08555	COG0783	Belongs to the Dps family
EXW44_RS08570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW44_RS08580	COG1231	oxidoreductase activity
EXW44_RS08585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS08590	COG4989	oxidoreductase activity
EXW44_RS08595	COG0523	cobalamin synthesis protein
EXW44_RS08600	COG0456	acetyltransferase
EXW44_RS08605	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW44_RS08620	COG1902	pentaerythritol trinitrate reductase activity
EXW44_RS08625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW44_RS08635	COG4166	transmembrane transport
EXW44_RS08640	COG0346	lactoylglutathione lyase activity
EXW44_RS08650	COG0406	alpha-ribazole phosphatase activity
EXW44_RS08660	COG5337	Spore coat protein CotH
EXW44_RS08665	COG1051	belongs to the nudix hydrolase family
EXW44_RS08670	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS08675	COG2244	polysaccharide biosynthetic process
EXW44_RS08685	COG0701	Predicted permease
EXW44_RS08690	COG3689	TIGRFAM TIGR03943 family protein
EXW44_RS08695	COG1607	acyl-coa hydrolase
EXW44_RS08705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW44_RS08720	COG0702	epimerase
EXW44_RS08725	COG2839	Protein conserved in bacteria
EXW44_RS08730	COG1253	flavin adenine dinucleotide binding
EXW44_RS08745	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS08750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW44_RS08765	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS08775	COG1876	peptidase activity
EXW44_RS08790	COG2211	Major facilitator Superfamily
EXW44_RS08805	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS08815	COG0561	phosphatase activity
EXW44_RS08825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW44_RS08840	COG1819	glycosyl
EXW44_RS08845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS08850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS08875	COG0456	acetyltransferase
EXW44_RS08910	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW44_RS08995	COG3874	Sporulation protein YtfJ
EXW44_RS09020	COG2226	methyltransferase
EXW44_RS09040	COG1082	Xylose isomerase domain protein TIM barrel
EXW44_RS09045	COG0346	lactoylglutathione lyase activity
EXW44_RS09055	COG0604	alcohol dehydrogenase
EXW44_RS09060	COG1595	DNA-templated transcription, initiation
EXW44_RS09085	COG0426	domain, Protein
EXW44_RS09085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW44_RS09095	COG0386	Belongs to the glutathione peroxidase family
EXW44_RS09100	COG1305	Transglutaminase-like
EXW44_RS09105	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW44_RS09110	COG0714	Associated with various cellular activities
EXW44_RS09115	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW44_RS09150	COG2359	stage V sporulation protein S
EXW44_RS09160	COG2856	Zn peptidase
EXW44_RS09190	COG1396	sequence-specific DNA binding
EXW44_RS09250	COG3344	reverse transcriptase
EXW44_RS09290	COG0582	viral genome integration into host DNA
EXW44_RS09315	COG0582	viral genome integration into host DNA
EXW44_RS09330	COG5484	DNA packaging
EXW44_RS09335	COG1783	phage Terminase large subunit
EXW44_RS09350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW44_RS09355	COG4653	Phage capsid family
EXW44_RS09480	COG1418	mRNA catabolic process
EXW44_RS09485	COG0488	(ABC) transporter
EXW44_RS09505	COG1413	lyase activity
EXW44_RS09520	COG2136	Putative SAM-dependent methyltransferase
EXW44_RS09520	COG2521	methyltransferase
EXW44_RS09525	COG0018	arginyl-trna synthetase
EXW44_RS09575	COG0017	Asparaginyl-tRNA synthetase
EXW44_RS09580	COG0733	neurotransmitter:sodium symporter activity
EXW44_RS09605	COG2610	gluconate transmembrane transporter activity
EXW44_RS09615	COG1794	racemase activity, acting on amino acids and derivatives
EXW44_RS09625	COG0456	acetyltransferase
EXW44_RS09630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW44_RS09640	COG1131	(ABC) transporter
EXW44_RS09645	COG4473	ABC transporter
EXW44_RS09655	COG0546	phosphoglycolate phosphatase activity
EXW44_RS09670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS09685	COG0768	penicillin binding
EXW44_RS09695	COG0204	Acyl-transferase
EXW44_RS09700	COG1272	protein, Hemolysin III
EXW44_RS09705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW44_RS09710	COG0805	protein transport
EXW44_RS09725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW44_RS09730	COG1999	signal sequence binding
EXW44_RS09735	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW44_RS09740	COG0367	asparagine synthase
EXW44_RS09755	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS09760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS09765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS09785	COG1335	isochorismatase
EXW44_RS09795	COG0668	transmembrane transport
EXW44_RS09800	COG2203	Gaf domain
EXW44_RS09800	COG4585	Histidine kinase
EXW44_RS09805	COG2197	response regulator
EXW44_RS09810	COG1737	Transcriptional regulator
EXW44_RS09815	COG1064	alcohol dehydrogenase
EXW44_RS09830	COG1070	Carbohydrate kinase
EXW44_RS09840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW44_RS09860	COG0517	IMP dehydrogenase activity
EXW44_RS09860	COG1125	glycine betaine transport
EXW44_RS09865	COG1174	glycine betaine transport
EXW44_RS09900	COG1253	flavin adenine dinucleotide binding
EXW44_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS09910	COG5506	Protein of unknown function (DUF1694)
EXW44_RS09925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW44_RS09930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW44_RS09935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW44_RS09940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW44_RS09945	COG0456	acetyltransferase
EXW44_RS09950	COG3829	transcription factor binding
EXW44_RS09955	COG1509	lysine 2,3-aminomutase activity
EXW44_RS09965	COG4479	Belongs to the UPF0346 family
EXW44_RS09990	COG0515	serine threonine protein kinase
EXW44_RS09990	COG3064	Membrane
EXW44_RS09990	COG4991	sh3 domain protein
EXW44_RS10000	COG0671	phosphoesterase, PA-phosphatase related
EXW44_RS10005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW44_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS10065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW44_RS10095	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS10115	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW44_RS10115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW44_RS10135	COG0372	Belongs to the citrate synthase family
EXW44_RS10140	COG2079	MmgE PrpD family protein
EXW44_RS10145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW44_RS10150	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS10155	COG2084	Dehydrogenase
EXW44_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS10165	COG1280	lysine exporter protein (LysE YggA)
EXW44_RS10170	COG1024	Enoyl-CoA hydratase
EXW44_RS10185	COG0420	3'-5' exonuclease activity
EXW44_RS10210	COG2223	nitrite transmembrane transporter activity
EXW44_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS10220	COG1169	isochorismate synthase
EXW44_RS10225	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW44_RS10230	COG3433	isochorismatase activity
EXW44_RS10230	COG1535	isochorismatase
EXW44_RS10235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW44_RS10240	COG3251	PFAM MbtH domain protein
EXW44_RS10245	COG2814	Major facilitator Superfamily
EXW44_RS10260	COG0776	regulation of translation
EXW44_RS10270	COG2318	DinB family
EXW44_RS10275	COG1115	amino acid carrier protein
EXW44_RS10290	COG2329	Antibiotic biosynthesis monooxygenase
EXW44_RS10300	COG1187	pseudouridine synthase activity
EXW44_RS10305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW44_RS10310	COG3655	Transcriptional regulator
EXW44_RS10320	COG1136	(ABC) transporter
EXW44_RS10330	COG0596	Alpha beta hydrolase
EXW44_RS10345	COG0028	Belongs to the TPP enzyme family
EXW44_RS10370	COG1253	flavin adenine dinucleotide binding
EXW44_RS10400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW44_RS10420	COG1846	Transcriptional regulator
EXW44_RS10430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS10435	COG1309	transcriptional regulator
EXW44_RS10465	COG1247	-acetyltransferase
EXW44_RS10495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW44_RS10505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS10535	COG0583	DNA-binding transcription factor activity
EXW44_RS10540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW44_RS10555	COG0583	DNA-binding transcription factor activity
EXW44_RS10560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS10565	COG2258	MOSC domain
EXW44_RS10580	COG1132	(ABC) transporter
EXW44_RS10585	COG1132	(ABC) transporter
EXW44_RS10600	COG0189	ligase activity
EXW44_RS10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS10620	COG4974	Belongs to the 'phage' integrase family
EXW44_RS10645	COG1396	sequence-specific DNA binding
EXW44_RS10680	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW44_RS10685	COG1595	DNA-templated transcription, initiation
EXW44_RS10760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW44_RS10760	COG2755	lipolytic protein G-D-S-L family
EXW44_RS10770	COG2169	Transcriptional regulator
EXW44_RS10780	COG0673	inositol 2-dehydrogenase activity
EXW44_RS10840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW44_RS10845	COG2971	BadF BadG BcrA BcrD
EXW44_RS10855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW44_RS10905	COG1309	transcriptional regulator
EXW44_RS10920	COG1136	(ABC) transporter
EXW44_RS10920	COG0577	efflux transmembrane transporter activity
EXW44_RS10925	COG0500	methyltransferase
EXW44_RS10925	COG3615	Tellurite resistance protein tehB
EXW44_RS10935	COG0693	protein deglycase activity
EXW44_RS10945	COG0588	phosphoglycerate mutase activity
EXW44_RS10970	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW44_RS10980	COG0110	maltose O-acetyltransferase activity
EXW44_RS10985	COG1136	(ABC) transporter
EXW44_RS11015	COG1136	(ABC) transporter
EXW44_RS11020	COG0577	efflux transmembrane transporter activity
EXW44_RS11040	COG1686	Belongs to the peptidase S11 family
EXW44_RS11065	COG0768	penicillin binding
EXW44_RS11070	COG0745	RESPONSE REGULATOR receiver
EXW44_RS11075	COG2205	protein histidine kinase activity
EXW44_RS11080	COG1136	(ABC) transporter
EXW44_RS11085	COG0577	efflux transmembrane transporter activity
EXW44_RS11095	COG1595	DNA-templated transcription, initiation
EXW44_RS11105	COG0768	penicillin binding
EXW44_RS11110	COG0768	penicillin binding
EXW44_RS11145	COG1252	NADH dehydrogenase
EXW44_RS11150	COG0425	Belongs to the sulfur carrier protein TusA family
EXW44_RS11150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS11165	COG0697	spore germination
EXW44_RS11190	COG3397	chitin binding
EXW44_RS11195	COG0823	Involved in the tonB-independent uptake of proteins
EXW44_RS11205	COG1408	metallophosphoesterase
EXW44_RS11215	COG1131	(ABC) transporter
EXW44_RS11225	COG1309	transcriptional regulator
EXW44_RS11235	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS11240	COG0439	Biotin carboxylase
EXW44_RS11245	COG0511	ligase activity, forming carbon-carbon bonds
EXW44_RS11250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW44_RS11255	COG1024	Enoyl-CoA hydratase
EXW44_RS11260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW44_RS11265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW44_RS11285	COG3344	reverse transcriptase
EXW44_RS11355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW44_RS11385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW44_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS11420	COG1733	regulation of RNA biosynthetic process
EXW44_RS11445	COG1309	transcriptional regulator
EXW44_RS11475	COG0697	spore germination
EXW44_RS11480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS11515	COG2323	membrane
EXW44_RS11530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS11535	COG0697	spore germination
EXW44_RS11555	COG0201	protein transport
EXW44_RS11565	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS11570	COG3227	Zinc metalloprotease (Elastase)
EXW44_RS11575	COG1523	belongs to the glycosyl hydrolase 13 family
EXW44_RS11590	COG0076	glutamate decarboxylase activity
EXW44_RS11595	COG0657	acetylesterase activity
EXW44_RS11600	COG1073	alpha beta
EXW44_RS11610	COG0577	efflux transmembrane transporter activity
EXW44_RS11615	COG1136	(ABC) transporter
EXW44_RS11630	COG5002	protein histidine kinase activity
EXW44_RS11635	COG0745	RESPONSE REGULATOR receiver
EXW44_RS11670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW44_RS11680	COG1183	phosphatidylcholine synthase activity
EXW44_RS11690	COG1132	(ABC) transporter
EXW44_RS11695	COG3961	Belongs to the TPP enzyme family
EXW44_RS11715	COG0322	excinuclease ABC activity
EXW44_RS11740	COG2318	DinB family
EXW44_RS11755	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW44_RS11810	COG1051	belongs to the nudix hydrolase family
EXW44_RS11815	COG0592	DNA-directed DNA polymerase activity
EXW44_RS11820	COG2816	NAD+ diphosphatase activity
EXW44_RS11830	COG2223	nitrite transmembrane transporter activity
EXW44_RS11840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS11850	COG0494	nUDIX hydrolase
EXW44_RS11870	COG0697	spore germination
EXW44_RS11890	COG0584	glycerophosphoryl diester phosphodiesterase
EXW44_RS11905	COG2814	Major facilitator Superfamily
EXW44_RS11945	COG0768	penicillin binding
EXW44_RS11950	COG0671	phosphoesterase, PA-phosphatase related
EXW44_RS11955	COG0604	alcohol dehydrogenase
EXW44_RS11960	COG5002	protein histidine kinase activity
EXW44_RS11965	COG0745	RESPONSE REGULATOR receiver
EXW44_RS11975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW44_RS11985	COG2205	protein histidine kinase activity
EXW44_RS12000	COG1122	ATPase activity
EXW44_RS12005	COG4720	Psort location CytoplasmicMembrane, score
EXW44_RS12010	COG1794	racemase activity, acting on amino acids and derivatives
EXW44_RS12015	COG1819	glycosyl
EXW44_RS12025	COG0768	penicillin binding
EXW44_RS12030	COG5002	protein histidine kinase activity
EXW44_RS12035	COG0561	phosphatase activity
EXW44_RS12080	COG2124	cytochrome p450
EXW44_RS12125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW44_RS12135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS12140	COG0460	homoserine dehydrogenase
EXW44_RS12160	COG0577	efflux transmembrane transporter activity
EXW44_RS12165	COG1136	(ABC) transporter
EXW44_RS12175	COG0488	(ABC) transporter
EXW44_RS12180	COG0667	Aldo Keto reductase
EXW44_RS12185	COG0583	DNA-binding transcription factor activity
EXW44_RS12190	COG2205	protein histidine kinase activity
EXW44_RS12195	COG0745	RESPONSE REGULATOR receiver
EXW44_RS12205	COG3773	Cell wall hydrolase
EXW44_RS12210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW44_RS12220	COG3386	PFAM SMP-30 Gluconolaconase
EXW44_RS12260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS12275	COG2959	enzyme of heme biosynthesis
EXW44_RS12300	COG3483	tryptophan 2,3-dioxygenase activity
EXW44_RS12305	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW44_RS12310	COG3844	kynureninase activity
EXW44_RS12315	COG1309	transcriptional regulator
EXW44_RS12330	COG3284	Transcriptional regulator
EXW44_RS12345	COG1349	DNA-binding transcription factor activity
EXW44_RS12365	COG1959	2 iron, 2 sulfur cluster binding
EXW44_RS12380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW44_RS12385	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW44_RS12390	COG0022	dehydrogenase e1 component
EXW44_RS12395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW44_RS12415	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS12420	COG0456	acetyltransferase
EXW44_RS12420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW44_RS12450	COG4176	ABC-type proline glycine betaine transport system permease component
EXW44_RS12455	COG0517	IMP dehydrogenase activity
EXW44_RS12455	COG4175	Glycine betaine
EXW44_RS12480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW44_RS12485	COG2153	protein acetylation
EXW44_RS12490	COG3397	chitin binding
EXW44_RS12500	COG1819	glycosyl
EXW44_RS12515	COG2205	protein histidine kinase activity
EXW44_RS12520	COG2315	Protein conserved in bacteria
EXW44_RS12565	COG3973	AAA domain
EXW44_RS12575	COG2105	PFAM AIG2 family protein
EXW44_RS12580	COG0514	ATP-dependent DNA helicase (RecQ)
EXW44_RS12605	COG4637	Psort location Cytoplasmic, score
EXW44_RS12615	COG1227	inorganic diphosphatase activity
EXW44_RS12620	COG3397	chitin binding
EXW44_RS12625	COG2318	DinB family
EXW44_RS12645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW44_RS12650	COG1115	amino acid carrier protein
EXW44_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS12660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW44_RS12670	COG3938	Belongs to the proline racemase family
EXW44_RS12675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW44_RS12715	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS12730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW44_RS12735	COG4166	transmembrane transport
EXW44_RS12745	COG4948	Mandelate Racemase Muconate Lactonizing
EXW44_RS12765	COG0667	Aldo Keto reductase
EXW44_RS12805	COG2936	dipeptidyl-peptidase activity
EXW44_RS12815	COG0745	RESPONSE REGULATOR receiver
EXW44_RS12845	COG1164	Oligoendopeptidase f
EXW44_RS12850	COG0531	amino acid
EXW44_RS12855	COG1522	sequence-specific DNA binding
EXW44_RS12870	COG1307	EDD domain protein, DegV family
EXW44_RS12895	COG1335	isochorismatase
EXW44_RS12910	COG2814	Major facilitator Superfamily
EXW44_RS12920	COG1664	Polymer-forming cytoskeletal
EXW44_RS12925	COG0789	Transcriptional regulator
EXW44_RS12930	COG4533	DNA binding
EXW44_RS12935	COG0477	Major facilitator Superfamily
EXW44_RS12935	COG2814	Major facilitator Superfamily
EXW44_RS12955	COG2261	transglycosylase associated protein
EXW44_RS12970	COG2226	methyltransferase
EXW44_RS13005	COG0436	Aminotransferase
EXW44_RS13010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW44_RS13040	COG1131	(ABC) transporter
EXW44_RS13045	COG2188	Transcriptional regulator
EXW44_RS13090	COG0628	permease
EXW44_RS13135	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW44_RS13145	COG0697	spore germination
EXW44_RS13150	COG2318	DinB family
EXW44_RS13200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS13210	COG2814	Major facilitator Superfamily
EXW44_RS13215	COG1368	sulfuric ester hydrolase activity
EXW44_RS13230	COG0488	(ABC) transporter
EXW44_RS13235	COG2409	Drug exporters of the RND superfamily
EXW44_RS13235	COG1033	growth of symbiont in host cell
EXW44_RS13240	COG1309	transcriptional regulator
EXW44_RS13260	COG0287	Prephenate dehydrogenase
EXW44_RS13275	COG1605	Chorismate mutase
EXW44_RS13275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW44_RS13320	COG3584	3D domain protein
EXW44_RS13320	COG1388	LysM domain
EXW44_RS13330	COG0346	lactoylglutathione lyase activity
EXW44_RS13340	COG0431	NADPH-dependent FMN reductase
EXW44_RS13365	COG0579	oxidoreductase
EXW44_RS13370	COG1879	ABC-type sugar transport system periplasmic component
EXW44_RS13385	COG1129	ABC transporter
EXW44_RS13390	COG2390	Transcriptional regulator
EXW44_RS13410	COG2226	methyltransferase
EXW44_RS13430	COG2329	Antibiotic biosynthesis monooxygenase
EXW44_RS13460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS13465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW44_RS13470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW44_RS13475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW44_RS13480	COG3239	Fatty acid desaturase
EXW44_RS13500	COG3842	ATPase activity
EXW44_RS13525	COG1175	transmembrane transport
EXW44_RS13530	COG1349	DNA-binding transcription factor activity
EXW44_RS13540	COG3655	Transcriptional regulator
EXW44_RS13555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS13560	COG0346	lactoylglutathione lyase activity
EXW44_RS13590	COG0714	Associated with various cellular activities
EXW44_RS13610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW44_RS13615	COG0753	catalase activity
EXW44_RS13625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW44_RS13650	COG0714	Associated with various cellular activities
EXW44_RS13660	COG0778	Nitroreductase
EXW44_RS13665	COG1846	Transcriptional regulator
EXW44_RS13800	COG0740	serine-type endopeptidase activity
EXW44_RS13810	COG4626	Terminase
EXW44_RS13810	COG1802	Transcriptional regulator
EXW44_RS13845	COG0582	viral genome integration into host DNA
EXW44_RS13895	COG2002	toxin-antitoxin pair type II binding
EXW44_RS13905	COG1484	DNA-dependent DNA replication
EXW44_RS13935	COG1396	sequence-specific DNA binding
EXW44_RS13960	COG0582	viral genome integration into host DNA
EXW44_RS13970	COG3831	ATPase activity
EXW44_RS13970	COG4884	unkown
EXW44_RS13990	COG2207	Transcriptional regulator
EXW44_RS13995	COG0456	acetyltransferase
EXW44_RS14010	COG0697	spore germination
EXW44_RS14015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS14040	COG0814	amino acid
EXW44_RS14045	COG0697	spore germination
EXW44_RS14060	COG0642	Histidine kinase
EXW44_RS14065	COG0745	RESPONSE REGULATOR receiver
EXW44_RS14070	COG0596	Alpha beta hydrolase
EXW44_RS14080	COG0456	acetyltransferase
EXW44_RS14080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW44_RS14105	COG0730	response to heat
EXW44_RS14115	COG0833	amino acid
EXW44_RS14125	COG4335	DNA alkylation repair
EXW44_RS14150	COG0681	Belongs to the peptidase S26 family
EXW44_RS14155	COG0768	penicillin binding
EXW44_RS14170	COG3104	oligopeptide transport
EXW44_RS14175	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW44_RS14190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW44_RS14195	COG1984	allophanate hydrolase subunit 2
EXW44_RS14200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW44_RS14205	COG1414	Transcriptional regulator
EXW44_RS14225	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS14250	COG0640	Transcriptional regulator
EXW44_RS14260	COG3314	Sporulation integral membrane protein YlbJ
EXW44_RS14280	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW44_RS14285	COG0577	efflux transmembrane transporter activity
EXW44_RS14290	COG0577	efflux transmembrane transporter activity
EXW44_RS14295	COG1136	(ABC) transporter
EXW44_RS14330	COG3848	Pyruvate phosphate dikinase
EXW44_RS14330	COG0574	Belongs to the PEP-utilizing enzyme family
EXW44_RS14340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW44_RS14360	COG0697	spore germination
EXW44_RS14385	COG1288	antiporter activity
EXW44_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS14400	COG3347	Dehydrogenase
EXW44_RS14410	COG1070	Carbohydrate kinase
EXW44_RS14415	COG0235	Class ii aldolase
EXW44_RS14425	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW44_RS14435	COG4154	Belongs to the RbsD FucU family
EXW44_RS14450	COG0798	PFAM Bile acid sodium symporter
EXW44_RS14455	COG0346	lactoylglutathione lyase activity
EXW44_RS14460	COG0640	Transcriptional regulator
EXW44_RS14475	COG1309	transcriptional regulator
EXW44_RS14485	COG1522	sequence-specific DNA binding
EXW44_RS14505	COG0346	lactoylglutathione lyase activity
EXW44_RS14535	COG0745	RESPONSE REGULATOR receiver
EXW44_RS14540	COG3850	Histidine kinase
EXW44_RS14540	COG5002	protein histidine kinase activity
EXW44_RS14570	COG1073	alpha beta
EXW44_RS14580	COG0814	amino acid
EXW44_RS14590	COG1760	l-serine dehydratase
EXW44_RS14600	COG5002	protein histidine kinase activity
EXW44_RS14605	COG0745	RESPONSE REGULATOR receiver
EXW44_RS14615	COG5002	protein histidine kinase activity
EXW44_RS14640	COG4977	sequence-specific DNA binding
EXW44_RS14680	COG2814	Major facilitator Superfamily
EXW44_RS14695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW44_RS14705	COG2309	aminopeptidase activity
EXW44_RS14715	COG1690	Belongs to the RtcB family
EXW44_RS14740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW44_RS14760	COG1136	(ABC) transporter
EXW44_RS14765	COG0577	efflux transmembrane transporter activity
EXW44_RS14785	COG3850	Histidine kinase
EXW44_RS14785	COG5002	protein histidine kinase activity
EXW44_RS14795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS14810	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW44_RS14830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW44_RS14865	COG2814	Major facilitator Superfamily
EXW44_RS14900	COG2849	repeat protein
EXW44_RS14905	COG5444	nuclease activity
EXW44_RS14915	COG5444	nuclease activity
EXW44_RS15015	COG0477	Major facilitator Superfamily
EXW44_RS15030	COG1846	Transcriptional regulator
EXW44_RS15035	COG2814	Major facilitator Superfamily
EXW44_RS15055	COG2211	Major facilitator Superfamily
EXW44_RS15085	COG0640	Transcriptional regulator
EXW44_RS15110	COG1329	Transcriptional regulator
EXW44_RS15165	COG5002	protein histidine kinase activity
EXW44_RS15180	COG1136	(ABC) transporter
EXW44_RS15195	COG1131	(ABC) transporter
EXW44_RS15305	COG4187	Peptidase family M20/M25/M40
EXW44_RS15320	COG2031	fatty acid transporter
EXW44_RS15330	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW44_RS15380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW44_RS15385	COG1288	antiporter activity
EXW44_RS15390	COG2356	endonuclease I
EXW44_RS15395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW44_RS15400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW44_RS15430	COG1785	Belongs to the alkaline phosphatase family
EXW44_RS15435	COG0778	Nitroreductase
EXW44_RS15440	COG1733	regulation of RNA biosynthetic process
EXW44_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS15465	COG1131	(ABC) transporter
EXW44_RS15495	COG1595	DNA-templated transcription, initiation
EXW44_RS15510	COG1011	Hydrolase
EXW44_RS15515	COG2365	Tyrosine phosphatase family
EXW44_RS15540	COG0346	lactoylglutathione lyase activity
EXW44_RS15545	COG1940	carbohydrate kinase activity
EXW44_RS15550	COG0738	Major facilitator superfamily
EXW44_RS15555	COG0110	maltose O-acetyltransferase activity
EXW44_RS15570	COG0628	permease
EXW44_RS15575	COG2261	transglycosylase associated protein
EXW44_RS15610	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW44_RS15620	COG1253	flavin adenine dinucleotide binding
EXW44_RS15625	COG0789	Transcriptional regulator
EXW44_RS15635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW44_RS15660	COG0697	spore germination
EXW44_RS15665	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW44_RS15670	COG3813	Protein conserved in bacteria
EXW44_RS15675	COG2706	6-phosphogluconolactonase activity
EXW44_RS15680	COG1070	Carbohydrate kinase
EXW44_RS15690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW44_RS15695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW44_RS15710	COG0814	amino acid
EXW44_RS15730	COG1393	Belongs to the ArsC family
EXW44_RS15740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS15755	COG0494	nUDIX hydrolase
EXW44_RS15770	COG0384	phenazine biosynthesis protein PhzF
EXW44_RS15780	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS15785	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW44_RS15790	COG1733	regulation of RNA biosynthetic process
EXW44_RS15805	COG1191	sigma factor activity
EXW44_RS15825	COG1876	peptidase activity
EXW44_RS15870	COG0741	lytic transglycosylase activity
EXW44_RS15895	COG5002	protein histidine kinase activity
EXW44_RS15935	COG0814	amino acid
EXW44_RS15960	COG1151	hydroxylamine reductase activity
EXW44_RS15985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS15995	COG2072	flavoprotein involved in K transport
EXW44_RS16040	COG1695	Transcriptional regulator
EXW44_RS16045	COG0604	alcohol dehydrogenase
EXW44_RS16050	COG1113	amino acid transport
EXW44_RS16060	COG2814	Major facilitator Superfamily
EXW44_RS16070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW44_RS16075	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS16085	COG0534	Mate efflux family protein
EXW44_RS16090	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS16095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW44_RS16110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW44_RS16115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW44_RS16135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS16140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS16145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS16150	COG3739	integral membrane protein
EXW44_RS16170	COG0583	DNA-binding transcription factor activity
EXW44_RS16195	COG1193	negative regulation of DNA recombination
EXW44_RS16215	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW44_RS16220	COG1164	Oligoendopeptidase f
EXW44_RS16245	COG3781	membrane
EXW44_RS16260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS16295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW44_RS16300	COG0640	Transcriptional regulator
EXW44_RS16305	COG0604	alcohol dehydrogenase
EXW44_RS16310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW44_RS16315	COG0457	Tetratricopeptide repeat
EXW44_RS16325	COG2808	Putative FMN-binding domain
EXW44_RS16330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW44_RS16340	COG0277	FAD linked oxidase domain protein
EXW44_RS16360	COG1285	pathogenesis
EXW44_RS16370	COG2514	catechol 2,3-dioxygenase activity
EXW44_RS16375	COG2720	vancomycin resistance protein
EXW44_RS16400	COG1278	Cold shock
EXW44_RS16410	COG0716	FMN binding
EXW44_RS16420	COG0494	nUDIX hydrolase
EXW44_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS16450	COG0165	Argininosuccinate lyase
EXW44_RS16465	COG4145	pantothenate transmembrane transporter activity
EXW44_RS16475	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS16480	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS16490	COG1657	PFAM Prenyltransferase squalene oxidase
EXW44_RS16495	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW44_RS16500	COG2962	Rard protein
EXW44_RS16505	COG3326	Membrane
EXW44_RS16510	COG0531	amino acid
EXW44_RS16545	COG2226	methyltransferase
EXW44_RS16550	COG4166	transmembrane transport
EXW44_RS16555	COG4166	transmembrane transport
EXW44_RS16560	COG4166	transmembrane transport
EXW44_RS16565	COG1316	TRANSCRIPTIONal
EXW44_RS16575	COG1595	DNA-templated transcription, initiation
EXW44_RS16585	COG1131	(ABC) transporter
EXW44_RS16605	COG0673	inositol 2-dehydrogenase activity
EXW44_RS16610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW44_RS16615	COG0187	DNA topoisomerase II activity
EXW44_RS16620	COG1832	CoA-binding protein
EXW44_RS16625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW44_RS16630	COG0745	RESPONSE REGULATOR receiver
EXW44_RS16640	COG1328	CTP reductase activity
EXW44_RS16650	COG4841	protein insertion into membrane
EXW44_RS16655	COG0824	Thioesterase
EXW44_RS16680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS16695	COG1132	(ABC) transporter
EXW44_RS16700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW44_RS16730	COG2211	Major facilitator Superfamily
EXW44_RS16740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW44_RS16755	COG0183	Belongs to the thiolase family
EXW44_RS16760	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS16765	COG1268	BioY protein
EXW44_RS16770	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS16775	COG1396	sequence-specific DNA binding
EXW44_RS16820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS16830	COG5002	protein histidine kinase activity
EXW44_RS16840	COG0400	carboxylic ester hydrolase activity
EXW44_RS16845	COG0346	lactoylglutathione lyase activity
EXW44_RS16850	COG0069	glutamate synthase activity
EXW44_RS16855	COG1902	pentaerythritol trinitrate reductase activity
EXW44_RS16865	COG1329	Transcriptional regulator
EXW44_RS16870	COG0010	Belongs to the arginase family
EXW44_RS16880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW44_RS16885	COG2986	histidine ammonia-lyase
EXW44_RS16895	COG2226	methyltransferase
EXW44_RS16920	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW44_RS16925	COG0785	Cytochrome C biogenesis protein
EXW44_RS16935	COG1473	amidohydrolase
EXW44_RS16940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW44_RS16945	COG1131	(ABC) transporter
EXW44_RS16955	COG0583	DNA-binding transcription factor activity
EXW44_RS16965	COG1346	cytolysis
EXW44_RS16980	COG0730	response to heat
EXW44_RS16990	COG3409	Peptidoglycan-binding domain 1 protein
EXW44_RS16990	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS17010	COG1132	(ABC) transporter
EXW44_RS17015	COG1132	(ABC) transporter
EXW44_RS17020	COG3763	UPF0154 protein
EXW44_RS17040	COG3639	organic phosphonate transmembrane transporter activity
EXW44_RS17050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW44_RS17055	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS17065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW44_RS17070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW44_RS17085	COG1695	Transcriptional regulator
EXW44_RS17090	COG1132	(ABC) transporter
EXW44_RS17120	COG0367	asparagine synthase
EXW44_RS17125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW44_RS17135	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW44_RS17140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW44_RS17145	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW44_RS17145	COG3420	alginic acid biosynthetic process
EXW44_RS17170	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS17180	COG0463	Glycosyl transferase, family 2
EXW44_RS17180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW44_RS17185	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS17190	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS17195	COG1086	Polysaccharide biosynthesis protein
EXW44_RS17200	COG0489	protein tyrosine kinase activity
EXW44_RS17205	COG3944	biosynthesis protein
EXW44_RS17210	COG0174	glutamine synthetase
EXW44_RS17215	COG0789	Transcriptional regulator
EXW44_RS17220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW44_RS17225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW44_RS17230	COG2860	membrane
EXW44_RS17240	COG0464	growth
EXW44_RS17265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW44_RS17275	COG1388	LysM domain
EXW44_RS17275	COG3584	3D domain protein
EXW44_RS17280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS17280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW44_RS17280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW44_RS17285	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW44_RS17290	COG1349	DNA-binding transcription factor activity
EXW44_RS17295	COG1979	alcohol dehydrogenase
EXW44_RS17300	COG2322	membrane
EXW44_RS17310	COG1113	amino acid transport
EXW44_RS17320	COG1473	amidohydrolase
EXW44_RS17325	COG1408	metallophosphoesterase
EXW44_RS17330	COG2116	formate transmembrane transporter activity
EXW44_RS17345	COG2217	Heavy metal translocating P-type atpase
EXW44_RS17350	COG2608	mercury ion transmembrane transporter activity
EXW44_RS17355	COG1937	Protein conserved in bacteria
EXW44_RS17385	COG4566	intracellular signal transduction
EXW44_RS17395	COG2819	hydrolase of the alpha beta superfamily
EXW44_RS17400	COG1120	ATPase activity
EXW44_RS17405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS17410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS17415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS17420	COG0708	Exodeoxyribonuclease III
EXW44_RS17425	COG2169	Transcriptional regulator
EXW44_RS17430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW44_RS17435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW44_RS17440	COG2706	6-phosphogluconolactonase activity
EXW44_RS17445	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW44_RS17450	COG2364	Membrane
EXW44_RS17460	COG0346	lactoylglutathione lyase activity
EXW44_RS17465	COG5001	Diguanylate cyclase
EXW44_RS17465	COG3300	MHYT domain
EXW44_RS17505	COG1346	cytolysis
EXW44_RS17515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS17520	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW44_RS17520	COG0596	Alpha beta hydrolase
EXW44_RS17525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW44_RS17535	COG2188	Transcriptional regulator
EXW44_RS17540	COG2723	6-phospho-beta-galactosidase activity
EXW44_RS17545	COG0823	Involved in the tonB-independent uptake of proteins
EXW44_RS17550	COG3773	Cell wall hydrolase
EXW44_RS17560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW44_RS17570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW44_RS17575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW44_RS17580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW44_RS17590	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW44_RS17595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW44_RS17600	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW44_RS17605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW44_RS17605	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW44_RS17615	COG2359	stage V sporulation protein S
EXW44_RS17620	COG1692	metallophosphoesterase
EXW44_RS17625	COG1418	mRNA catabolic process
EXW44_RS17630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW44_RS17635	COG1546	Belongs to the CinA family
EXW44_RS17635	COG1058	Belongs to the CinA family
EXW44_RS17640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW44_RS17645	COG1426	Protein conserved in bacteria
EXW44_RS17660	COG0300	oxidoreductase activity
EXW44_RS17665	COG0612	Peptidase, M16
EXW44_RS17670	COG0612	Peptidase, M16
EXW44_RS17675	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW44_RS17680	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW44_RS17685	COG3845	ABC transporter
EXW44_RS17690	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW44_RS17695	COG2188	Transcriptional regulator
EXW44_RS17705	COG1674	ftsk spoiiie
EXW44_RS17715	COG0740	serine-type endopeptidase activity
EXW44_RS17720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW44_RS17730	COG0527	aspartate kinase activity
EXW44_RS17735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW44_RS17740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW44_RS17745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW44_RS17750	COG1873	PFAM PRC-barrel domain
EXW44_RS17755	COG0612	Peptidase, M16
EXW44_RS17760	COG0726	polysaccharide deacetylase
EXW44_RS17765	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW44_RS17775	COG0196	riboflavin kinase activity
EXW44_RS17785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW44_RS17790	COG1550	Protein conserved in bacteria
EXW44_RS17795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW44_RS17800	COG1358	cellular component organization or biogenesis
EXW44_RS17805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW44_RS17810	COG0195	Participates in both transcription termination and antitermination
EXW44_RS17815	COG0779	Required for maturation of 30S ribosomal subunits
EXW44_RS17825	COG0442	prolyl-tRNA aminoacylation
EXW44_RS17830	COG0750	zinc metalloprotease
EXW44_RS17840	COG4589	Belongs to the CDS family
EXW44_RS17850	COG0233	cytoplasmic translational termination
EXW44_RS17855	COG0528	UMP kinase activity
EXW44_RS17860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW44_RS17870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW44_RS17875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW44_RS17880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW44_RS17885	COG4974	Belongs to the 'phage' integrase family
EXW44_RS17890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW44_RS17895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW44_RS17900	COG0758	DNA mediated transformation
EXW44_RS17905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW44_RS17910	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW44_RS17915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW44_RS17930	COG0335	large ribosomal subunit rRNA binding
EXW44_RS17935	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW44_RS17940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW44_RS17945	COG1837	Belongs to the UPF0109 family
EXW44_RS17955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW44_RS17965	COG0552	protein localization to endoplasmic reticulum
EXW44_RS17970	COG1196	nuclear chromosome segregation
EXW44_RS17975	COG0571	ribonuclease III activity
EXW44_RS17980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW44_RS17985	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS17990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW44_RS17995	COG0416	fatty acid biosynthetic process
EXW44_RS18000	COG2050	protein possibly involved in aromatic compounds catabolism
EXW44_RS18000	COG1349	DNA-binding transcription factor activity
EXW44_RS18005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW44_RS18010	COG1461	Dihydroxyacetone kinase
EXW44_RS18015	COG1302	Protein conserved in bacteria
EXW44_RS18030	COG1564	THIamine pyrophosphokinase
EXW44_RS18035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW44_RS18045	COG2815	serine threonine protein kinase
EXW44_RS18045	COG0515	serine threonine protein kinase
EXW44_RS18050	COG0631	protein serine/threonine phosphatase activity
EXW44_RS18055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW44_RS18060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW44_RS18060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW44_RS18065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW44_RS18070	COG0242	peptide deformylase activity
EXW44_RS18075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW44_RS18080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW44_RS18085	COG1758	RNA polymerase activity
EXW44_RS18100	COG1561	YicC-like family, N-terminal region
EXW44_RS18105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW44_RS18115	COG0006	proline dipeptidase activity
EXW44_RS18135	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW44_RS18145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXW44_RS18155	COG0167	dihydroorotate dehydrogenase activity
EXW44_RS18160	COG0543	2 iron, 2 sulfur cluster binding
EXW44_RS18165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW44_RS18175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW44_RS18180	COG0540	Belongs to the ATCase OTCase family
EXW44_RS18190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW44_RS18195	COG0564	pseudouridine synthase activity
EXW44_RS18200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW44_RS18210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW44_RS18215	COG3599	regulation of cell shape
EXW44_RS18220	COG2302	S4 RNA-binding domain
EXW44_RS18225	COG0762	integral membrane protein
EXW44_RS18230	COG1799	cell septum assembly
EXW44_RS18235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW44_RS18245	COG1873	PFAM PRC-barrel domain
EXW44_RS18250	COG1191	sigma factor activity
EXW44_RS18255	COG1191	sigma factor activity
EXW44_RS18265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW44_RS18270	COG0849	cell division
EXW44_RS18275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW44_RS18290	COG0772	Belongs to the SEDS family
EXW44_RS18295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW44_RS18300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW44_RS18305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW44_RS18310	COG0768	penicillin binding
EXW44_RS18315	COG0768	penicillin binding
EXW44_RS18325	COG0275	rRNA processing
EXW44_RS18330	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW44_RS18335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW44_RS18340	COG0454	-acetyltransferase
EXW44_RS18350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW44_RS18355	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW44_RS18360	COG1323	Belongs to the UPF0348 family
EXW44_RS18365	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW44_RS18370	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW44_RS18375	COG3314	Sporulation integral membrane protein YlbJ
EXW44_RS18385	COG0742	ribosomal rna small subunit methyltransferase
EXW44_RS18395	COG4471	UPF0298 protein
EXW44_RS18400	COG3679	Belongs to the UPF0342 family
EXW44_RS18405	COG0406	alpha-ribazole phosphatase activity
EXW44_RS18420	COG2340	Cysteine-rich secretory protein family
EXW44_RS18430	COG3336	cytochrome c oxidase
EXW44_RS18455	COG0109	protoheme IX farnesyltransferase activity
EXW44_RS18460	COG1612	heme a metabolic process
EXW44_RS18465	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW44_RS18470	COG0772	Belongs to the SEDS family
EXW44_RS18475	COG4838	Belongs to the UPF0358 family
EXW44_RS18480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW44_RS18485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW44_RS18495	COG4896	Protein conserved in bacteria
EXW44_RS18510	COG1217	gtp-binding protein TYPA
EXW44_RS18520	COG0483	inositol monophosphate 1-phosphatase activity
EXW44_RS18530	COG4493	Belongs to the UPF0637 family
EXW44_RS18535	COG4476	Belongs to the UPF0223 family
EXW44_RS18540	COG1982	Orn Lys Arg decarboxylase major
EXW44_RS18585	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW44_RS18590	COG0022	dehydrogenase e1 component
EXW44_RS18595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW44_RS18610	COG0561	phosphatase activity
EXW44_RS18615	COG5503	Protein of unknown function (DUF1447)
EXW44_RS18620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW44_RS18625	COG0569	domain protein
EXW44_RS18635	COG1473	amidohydrolase
EXW44_RS18640	COG2171	N-acyltransferase activity
EXW44_RS18645	COG0583	DNA-binding transcription factor activity
EXW44_RS18650	COG0517	IMP dehydrogenase activity
EXW44_RS18660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW44_RS18670	COG4703	Protein of unknown function (DUF1797)
EXW44_RS18685	COG2200	EAL domain
EXW44_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS18695	COG1408	metallophosphoesterase
EXW44_RS18740	COG2814	Major facilitator Superfamily
EXW44_RS18750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW44_RS18760	COG3209	COG3209 Rhs family protein
EXW44_RS18770	COG2205	protein histidine kinase activity
EXW44_RS18780	COG0436	Aminotransferase
EXW44_RS18785	COG1609	Transcriptional regulator
EXW44_RS18790	COG3833	ABC-type maltose transport systems, permease component
EXW44_RS18795	COG1175	transmembrane transport
EXW44_RS18800	COG2182	Extracellular solute-binding protein
EXW44_RS18810	COG0366	Alpha amylase catalytic
EXW44_RS18815	COG3842	ATPase activity
EXW44_RS18855	COG0183	Belongs to the thiolase family
EXW44_RS18890	COG1695	Transcriptional regulator
EXW44_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS18905	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW44_RS18910	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW44_RS18915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW44_RS18920	COG0436	Aminotransferase
EXW44_RS18925	COG1850	ribulose-bisphosphate carboxylase activity
EXW44_RS18930	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW44_RS18935	COG0235	Class ii aldolase
EXW44_RS18940	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW44_RS18955	COG2084	Dehydrogenase
EXW44_RS18965	COG2199	diguanylate cyclase activity
EXW44_RS18970	COG0778	Nitroreductase
EXW44_RS18995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW44_RS18995	COG1263	PTS System
EXW44_RS18995	COG2190	(PTS) system
EXW44_RS19000	COG3711	transcriptional antiterminator
EXW44_RS19010	COG2188	Transcriptional regulator
EXW44_RS19015	COG0363	glucosamine-6-phosphate deaminase activity
EXW44_RS19020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW44_RS19030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW44_RS19035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW44_RS19045	COG1547	Domain of unknown function (DUF309)
EXW44_RS19055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW44_RS19060	COG4086	secreted protein
EXW44_RS19065	COG0561	phosphatase activity
EXW44_RS19070	COG0697	spore germination
EXW44_RS19085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW44_RS19125	COG1686	Belongs to the peptidase S11 family
EXW44_RS19130	COG1725	Transcriptional regulator
EXW44_RS19135	COG1131	(ABC) transporter
EXW44_RS19160	COG1846	Transcriptional regulator
EXW44_RS19175	COG0598	Magnesium transport protein CorA
EXW44_RS19190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW44_RS19200	COG4974	Belongs to the 'phage' integrase family
EXW44_RS19210	COG0735	belongs to the Fur family
EXW44_RS19215	COG1300	Membrane
EXW44_RS19235	COG0667	Aldo Keto reductase
EXW44_RS19240	COG0656	L-ascorbic acid biosynthetic process
EXW44_RS19245	COG0456	acetyltransferase
EXW44_RS19245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW44_RS19255	COG4085	toxin activity
EXW44_RS19255	COG1525	nuclease
EXW44_RS19255	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS19260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW44_RS19270	COG0596	Alpha beta hydrolase
EXW44_RS19275	COG2056	Na+-H+ antiporter family
EXW44_RS19280	COG1609	Transcriptional regulator
EXW44_RS19285	COG0456	acetyltransferase
EXW44_RS19290	COG1073	alpha beta
EXW44_RS19305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW44_RS19305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW44_RS19310	COG0307	riboflavin synthase, alpha
EXW44_RS19315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW44_RS19315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW44_RS19330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW44_RS19335	COG4106	trans-aconitate 2-methyltransferase activity
EXW44_RS19340	COG1073	alpha beta
EXW44_RS19340	COG2226	methyltransferase
EXW44_RS19345	COG0156	8-amino-7-oxononanoate synthase activity
EXW44_RS19355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW44_RS19365	COG1757	Na H antiporter
EXW44_RS19370	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS19380	COG1522	sequence-specific DNA binding
EXW44_RS19415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW44_RS19425	COG0300	oxidoreductase activity
EXW44_RS19430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS19435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW44_RS19440	COG1760	l-serine dehydratase
EXW44_RS19445	COG1760	l-serine dehydratase
EXW44_RS19455	COG1234	tRNA 3'-trailer cleavage
EXW44_RS19470	COG1285	pathogenesis
EXW44_RS19485	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW44_RS19490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS19505	COG1376	ErfK ybiS ycfS ynhG family protein
EXW44_RS19510	COG4129	membrane
EXW44_RS19515	COG1126	abc transporter atp-binding protein
EXW44_RS19520	COG0765	amino acid transport
EXW44_RS19525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW44_RS19540	COG2816	NAD+ diphosphatase activity
EXW44_RS19545	COG2323	membrane
EXW44_RS19550	COG0772	Belongs to the SEDS family
EXW44_RS19555	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW44_RS19560	COG0022	dehydrogenase e1 component
EXW44_RS19565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW44_RS19570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW44_RS19575	COG3426	butyrate kinase activity
EXW44_RS19585	COG0280	phosphate acetyltransferase
EXW44_RS19590	COG3829	transcription factor binding
EXW44_RS19590	COG3290	protein histidine kinase activity
EXW44_RS19600	COG0584	glycerophosphoryl diester phosphodiesterase
EXW44_RS19605	COG3093	addiction module antidote protein HigA
EXW44_RS19615	COG0745	RESPONSE REGULATOR receiver
EXW44_RS19620	COG0750	zinc metalloprotease
EXW44_RS19625	COG0497	DNA recombination
EXW44_RS19630	COG1438	arginine binding
EXW44_RS19635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW44_RS19640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW44_RS19645	COG0142	geranyltranstransferase activity
EXW44_RS19650	COG1722	exodeoxyribonuclease VII activity
EXW44_RS19655	COG1570	exodeoxyribonuclease VII activity
EXW44_RS19660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW44_RS19665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW44_RS19670	COG1302	Protein conserved in bacteria
EXW44_RS19675	COG0439	Biotin carboxylase
EXW44_RS19680	COG0511	ligase activity, forming carbon-carbon bonds
EXW44_RS19725	COG3854	ATPases associated with a variety of cellular activities
EXW44_RS19745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW44_RS19750	COG0006	proline dipeptidase activity
EXW44_RS19755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW44_RS19765	COG3872	metal-dependent enzyme
EXW44_RS19775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW44_RS19810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS19820	COG1609	Transcriptional regulator
EXW44_RS19830	COG2076	Multidrug Resistance protein
EXW44_RS19835	COG2076	Multidrug Resistance protein
EXW44_RS19875	COG1725	Transcriptional regulator
EXW44_RS19890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW44_RS19895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW44_RS19900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW44_RS19905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW44_RS19935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW44_RS19960	COG4970	Tfp pilus assembly protein FimT
EXW44_RS19970	COG1459	type II secretion system
EXW44_RS19975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW44_RS20030	COG0646	methionine synthase
EXW44_RS20030	COG1410	methionine synthase
EXW44_RS20035	COG0646	methionine synthase
EXW44_RS20035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW44_RS20040	COG0626	cystathionine gamma-synthase activity
EXW44_RS20045	COG0626	cystathionine gamma-synthase activity
EXW44_RS20065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS20075	COG1940	carbohydrate kinase activity
EXW44_RS20080	COG4483	Protein conserved in bacteria
EXW44_RS20085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW44_RS20090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW44_RS20095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW44_RS20100	COG0704	Plays a role in the regulation of phosphate uptake
EXW44_RS20110	COG0581	inorganic phosphate transmembrane transporter activity
EXW44_RS20115	COG0573	inorganic phosphate transmembrane transporter activity
EXW44_RS20120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW44_RS20125	COG0768	penicillin binding
EXW44_RS20130	COG0477	Major facilitator Superfamily
EXW44_RS20135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW44_RS20155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW44_RS20160	COG0735	belongs to the Fur family
EXW44_RS20165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW44_RS20170	COG1121	(ABC) transporter
EXW44_RS20175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS20185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW44_RS20200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW44_RS20205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW44_RS20210	COG2384	SAM-dependent methyltransferase
EXW44_RS20215	COG2010	Cytochrome c
EXW44_RS20220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW44_RS20225	COG0358	DNA primase activity
EXW44_RS20235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW44_RS20240	COG0517	IMP dehydrogenase activity
EXW44_RS20245	COG1381	Involved in DNA repair and RecF pathway recombination
EXW44_RS20255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW44_RS20260	COG0295	cytidine deaminase activity
EXW44_RS20265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW44_RS20270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW44_RS20275	COG1480	7TM receptor with intracellular HD hydrolase
EXW44_RS20280	COG1702	phosphate starvation-inducible protein PhoH
EXW44_RS20295	COG1610	YqeY-like protein
EXW44_RS20300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW44_RS20305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW44_RS20310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW44_RS20320	COG0484	heat shock protein binding
EXW44_RS20330	COG0443	Heat shock 70 kDa protein
EXW44_RS20340	COG1420	regulation of RNA biosynthetic process
EXW44_RS20345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW44_RS20350	COG1733	regulation of RNA biosynthetic process
EXW44_RS20355	COG0481	GTPase activity
EXW44_RS20365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW44_RS20370	COG0268	Binds directly to 16S ribosomal RNA
EXW44_RS20375	COG1466	dna polymerase III delta subunit
EXW44_RS20385	COG0658	competence protein
EXW44_RS20385	COG2333	competence protein COMEC
EXW44_RS20390	COG2131	deaminase
EXW44_RS20395	COG1555	photosystem II stabilization
EXW44_RS20395	COG1596	polysaccharide export
EXW44_RS20400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW44_RS20405	COG2226	methyltransferase
EXW44_RS20410	COG0799	negative regulation of ribosome biogenesis
EXW44_RS20415	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW44_RS20420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW44_RS20425	COG1534	Rna-binding protein
EXW44_RS20430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW44_RS20435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW44_RS20440	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW44_RS20450	COG0688	phosphatidylethanolamine metabolic process
EXW44_RS20460	COG1595	DNA-templated transcription, initiation
EXW44_RS20465	COG2357	RelA SpoT domain protein
EXW44_RS20475	COG1785	Belongs to the alkaline phosphatase family
EXW44_RS20485	COG2267	carboxylic ester hydrolase activity
EXW44_RS20520	COG1404	Belongs to the peptidase S8 family
EXW44_RS20525	COG3186	Phenylalanine-4-hydroxylase
EXW44_RS20530	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW44_RS20535	COG2514	catechol 2,3-dioxygenase activity
EXW44_RS20540	COG2259	Doxx family
EXW44_RS20580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS20590	COG1454	alcohol dehydrogenase
EXW44_RS20590	COG1012	belongs to the aldehyde dehydrogenase family
EXW44_RS20595	COG0626	cystathionine gamma-synthase activity
EXW44_RS20600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW44_RS20605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW44_RS20610	COG2226	methyltransferase
EXW44_RS20625	COG0768	penicillin binding
EXW44_RS20630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW44_RS20635	COG0572	uridine kinase
EXW44_RS20640	COG0826	peptidase U32
EXW44_RS20645	COG0826	peptidase U32
EXW44_RS20650	COG4122	O-methyltransferase activity
EXW44_RS20655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW44_RS20665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW44_RS20670	COG4472	Bacterial protein of unknown function (DUF965)
EXW44_RS20675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW44_RS20685	COG0628	permease
EXW44_RS20705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW44_RS20715	COG0482	sulfurtransferase activity
EXW44_RS20720	COG1104	cysteine desulfurase activity
EXW44_RS20725	COG1959	2 iron, 2 sulfur cluster binding
EXW44_RS20730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW44_RS20740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW44_RS20745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW44_RS20760	COG1490	D-aminoacyl-tRNA deacylase activity
EXW44_RS20765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW44_RS20770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW44_RS20775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW44_RS20775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW44_RS20780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW44_RS20785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW44_RS20785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW44_RS20795	COG2244	polysaccharide biosynthetic process
EXW44_RS20800	COG2323	membrane
EXW44_RS20810	COG1862	Preprotein translocase
EXW44_RS20815	COG0343	queuine tRNA-ribosyltransferase activity
EXW44_RS20820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW44_RS20830	COG2255	four-way junction helicase activity
EXW44_RS20835	COG0632	four-way junction helicase activity
EXW44_RS20840	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW44_RS20865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW44_RS20870	COG0157	Belongs to the NadC ModD family
EXW44_RS20875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW44_RS20880	COG1104	cysteine desulfurase activity
EXW44_RS20885	COG1827	regulation of RNA biosynthetic process
EXW44_RS20890	COG2258	MOSC domain
EXW44_RS20895	COG0077	Prephenate dehydratase
EXW44_RS20900	COG0577	efflux transmembrane transporter activity
EXW44_RS20905	COG0577	efflux transmembrane transporter activity
EXW44_RS20910	COG1136	(ABC) transporter
EXW44_RS20915	COG5002	protein histidine kinase activity
EXW44_RS20920	COG0745	RESPONSE REGULATOR receiver
EXW44_RS20925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW44_RS20930	COG3290	protein histidine kinase activity
EXW44_RS20940	COG2868	ribosomal protein
EXW44_RS20950	COG1530	ribonuclease E activity
EXW44_RS20955	COG1994	Peptidase M50
EXW44_RS20960	COG0739	heme binding
EXW44_RS20965	COG2894	cell division
EXW44_RS20970	COG0850	regulation of cytokinetic process
EXW44_RS20985	COG1077	Cell shape determining protein MreB Mrl
EXW44_RS20990	COG2003	Belongs to the UPF0758 family
EXW44_RS20995	COG0424	maF-like protein
EXW44_RS21005	COG0285	dihydrofolate synthase activity
EXW44_RS21020	COG1388	LysM domain
EXW44_RS21025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW44_RS21030	COG0113	porphobilinogen synthase activity
EXW44_RS21035	COG1587	Uroporphyrinogen-III synthase
EXW44_RS21040	COG0181	hydroxymethylbilane synthase activity
EXW44_RS21045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW44_RS21050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW44_RS21055	COG1846	Transcriptional regulator
EXW44_RS21060	COG1764	response to oxidative stress
EXW44_RS21065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW44_RS21075	COG0470	DNA polymerase III
EXW44_RS21075	COG1067	ATP-dependent peptidase activity
EXW44_RS21085	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW44_RS21115	COG0622	Phosphoesterase
EXW44_RS21125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW44_RS21130	COG5401	PFAM Sporulation and spore germination
EXW44_RS21140	COG0477	Major facilitator Superfamily
EXW44_RS21145	COG2197	response regulator
EXW44_RS21150	COG2233	PERMEase
EXW44_RS21155	COG0402	S-adenosylhomocysteine deaminase activity
EXW44_RS21160	COG1983	PspC domain protein
EXW44_RS21165	COG1396	sequence-specific DNA binding
EXW44_RS21170	COG0697	spore germination
EXW44_RS21180	COG1959	2 iron, 2 sulfur cluster binding
EXW44_RS21185	COG1668	transmembrane transport
EXW44_RS21190	COG4152	abc transporter atp-binding protein
EXW44_RS21195	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW44_RS21200	COG1360	Flagellar Motor Protein
EXW44_RS21205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW44_RS21210	COG1876	peptidase activity
EXW44_RS21215	COG0824	Thioesterase
EXW44_RS21220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW44_RS21225	COG1053	succinate dehydrogenase
EXW44_RS21230	COG2009	succinate dehydrogenase
EXW44_RS21235	COG1719	4-vinyl reductase, 4VR
EXW44_RS21240	COG0322	excinuclease ABC activity
EXW44_RS21245	COG3118	belongs to the thioredoxin family
EXW44_RS21250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW44_RS21255	COG2086	electron transfer activity
EXW44_RS21260	COG1024	Enoyl-CoA hydratase
EXW44_RS21265	COG1309	transcriptional regulator
EXW44_RS21270	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS21295	COG2318	DinB family
EXW44_RS21320	COG1131	(ABC) transporter
EXW44_RS21325	COG2205	protein histidine kinase activity
EXW44_RS21330	COG0745	RESPONSE REGULATOR receiver
EXW44_RS21340	COG4895	conserved protein (DUF2196)
EXW44_RS21345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW44_RS21355	COG4509	Sortase family
EXW44_RS21360	COG1120	ATPase activity
EXW44_RS21375	COG5386	Cell surface protein
EXW44_RS21385	COG5386	Cell surface protein
EXW44_RS21390	COG1114	Component of the transport system for branched-chain amino acids
EXW44_RS21400	COG1193	negative regulation of DNA recombination
EXW44_RS21405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW44_RS21405	COG1796	DNA polymerase
EXW44_RS21410	COG1286	toxin biosynthetic process
EXW44_RS21415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW44_RS21420	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW44_RS21445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW44_RS21450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW44_RS21460	COG1418	mRNA catabolic process
EXW44_RS21490	COG2814	Major facilitator Superfamily
EXW44_RS21495	COG1566	PFAM secretion protein HlyD family protein
EXW44_RS21500	COG1309	transcriptional regulator
EXW44_RS21505	COG1363	Peptidase, m42
EXW44_RS21515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW44_RS21530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW44_RS21540	COG1484	DNA-dependent DNA replication
EXW44_RS21545	COG3611	Membrane attachment protein
EXW44_RS21550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW44_RS21555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW44_RS21560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW44_RS21565	COG0237	dephospho-CoA kinase activity
EXW44_RS21570	COG1971	Probably functions as a manganese efflux pump
EXW44_RS21580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW44_RS21580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW44_RS21585	COG5002	protein histidine kinase activity
EXW44_RS21590	COG0745	RESPONSE REGULATOR receiver
EXW44_RS21605	COG0039	L-malate dehydrogenase activity
EXW44_RS21610	COG0538	isocitrate dehydrogenase activity
EXW44_RS21615	COG0372	Belongs to the citrate synthase family
EXW44_RS21625	COG0628	permease
EXW44_RS21630	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW44_RS21640	COG0205	6-phosphofructokinase activity
EXW44_RS21650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW44_RS21655	COG1725	Transcriptional regulator
EXW44_RS21660	COG0281	malic enzyme
EXW44_RS21665	COG0587	DNA-directed DNA polymerase activity
EXW44_RS21680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW44_RS21695	COG4109	DRTGG domain
EXW44_RS21710	COG0006	proline dipeptidase activity
EXW44_RS21740	COG0662	Cupin 2, conserved barrel domain protein
EXW44_RS21750	COG1476	TRANSCRIPTIONal
EXW44_RS21765	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS21770	COG0589	response to stress
EXW44_RS21800	COG0137	argininosuccinate synthase activity
EXW44_RS21815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS21835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW44_RS21840	COG0827	DNA restriction-modification system
EXW44_RS21845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW44_RS21850	COG3874	Sporulation protein YtfJ
EXW44_RS21865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW44_RS21875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW44_RS21890	COG1104	cysteine desulfurase activity
EXW44_RS21895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW44_RS21910	COG1309	transcriptional regulator
EXW44_RS21915	COG1956	GAF domain-containing protein
EXW44_RS21920	COG0626	cystathionine gamma-synthase activity
EXW44_RS21925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW44_RS21950	COG1595	DNA-templated transcription, initiation
EXW44_RS21960	COG0110	maltose O-acetyltransferase activity
EXW44_RS21965	COG0456	acetyltransferase
EXW44_RS21970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW44_RS21975	COG0454	-acetyltransferase
EXW44_RS21980	COG0517	IMP dehydrogenase activity
EXW44_RS21985	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW44_RS22000	COG0745	RESPONSE REGULATOR receiver
EXW44_RS22005	COG5002	protein histidine kinase activity
EXW44_RS22020	COG1970	mechanosensitive ion channel activity
EXW44_RS22040	COG1609	Transcriptional regulator
EXW44_RS22055	COG4851	CamS sex pheromone cAM373 precursor
EXW44_RS22060	COG3118	belongs to the thioredoxin family
EXW44_RS22070	COG2309	aminopeptidase activity
EXW44_RS22100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW44_RS22110	COG1674	ftsk spoiiie
EXW44_RS22125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW44_RS22130	COG4848	Belongs to the UPF0354 family
EXW44_RS22135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS22140	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW44_RS22145	COG1363	Peptidase, m42
EXW44_RS22155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS22160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW44_RS22170	COG0510	thiamine kinase activity
EXW44_RS22175	COG1523	belongs to the glycosyl hydrolase 13 family
EXW44_RS22185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW44_RS22190	COG1349	DNA-binding transcription factor activity
EXW44_RS22195	COG1187	pseudouridine synthase activity
EXW44_RS22200	COG2244	polysaccharide biosynthetic process
EXW44_RS22205	COG2081	HI0933 family
EXW44_RS22210	COG2814	Major facilitator Superfamily
EXW44_RS22220	COG3832	glyoxalase III activity
EXW44_RS22240	COG1329	Transcriptional regulator
EXW44_RS22265	COG0314	molybdopterin synthase activity
EXW44_RS22270	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW44_RS22275	COG0303	'Molybdopterin
EXW44_RS22280	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW44_RS22285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW44_RS22290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW44_RS22310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW44_RS22320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW44_RS22360	COG0495	leucyl-tRNA aminoacylation
EXW44_RS22365	COG2814	Major facilitator Superfamily
EXW44_RS22370	COG0475	glutathione-regulated potassium exporter activity
EXW44_RS22375	COG0490	domain, Protein
EXW44_RS22380	COG0582	viral genome integration into host DNA
EXW44_RS22390	COG1136	(ABC) transporter
EXW44_RS22405	COG1242	4 iron, 4 sulfur cluster binding
EXW44_RS22410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW44_RS22415	COG1131	(ABC) transporter
EXW44_RS22425	COG1794	racemase activity, acting on amino acids and derivatives
EXW44_RS22440	COG2267	carboxylic ester hydrolase activity
EXW44_RS22445	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW44_RS22450	COG0671	phosphoesterase, PA-phosphatase related
EXW44_RS22455	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS22465	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW44_RS22490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW44_RS22495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW44_RS22535	COG5002	protein histidine kinase activity
EXW44_RS22540	COG3852	Histidine kinase
EXW44_RS22545	COG0753	catalase activity
EXW44_RS22550	COG2267	carboxylic ester hydrolase activity
EXW44_RS22560	COG1368	sulfuric ester hydrolase activity
EXW44_RS22570	COG4895	conserved protein (DUF2196)
EXW44_RS22585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW44_RS22590	COG1116	anion transmembrane transporter activity
EXW44_RS22595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW44_RS22620	COG0494	nUDIX hydrolase
EXW44_RS22655	COG2076	Multidrug Resistance protein
EXW44_RS22665	COG0789	Transcriptional regulator
EXW44_RS22670	COG1854	S-ribosylhomocysteine lyase activity
EXW44_RS22680	COG0288	reversible hydration of carbon dioxide
EXW44_RS22685	COG1271	oxidase subunit
EXW44_RS22690	COG1294	oxidase, subunit
EXW44_RS22710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS22735	COG1842	Phage shock protein A
EXW44_RS22760	COG3859	Proton-coupled thiamine transporter YuaJ
EXW44_RS22765	COG5002	protein histidine kinase activity
EXW44_RS22770	COG0745	RESPONSE REGULATOR receiver
EXW44_RS22795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW44_RS22800	COG1597	lipid kinase activity
EXW44_RS22835	COG1136	(ABC) transporter
EXW44_RS22865	COG5002	protein histidine kinase activity
EXW44_RS22875	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS22890	COG0577	efflux transmembrane transporter activity
EXW44_RS22895	COG1136	(ABC) transporter
EXW44_RS22900	COG3708	Transcriptional regulator
EXW44_RS22900	COG2207	Transcriptional regulator
EXW44_RS22910	COG1131	(ABC) transporter
EXW44_RS22920	COG5658	integral membrane protein
EXW44_RS22925	COG0640	Transcriptional regulator
EXW44_RS22930	COG0745	RESPONSE REGULATOR receiver
EXW44_RS22935	COG2205	protein histidine kinase activity
EXW44_RS22940	COG0577	efflux transmembrane transporter activity
EXW44_RS22945	COG0577	efflux transmembrane transporter activity
EXW44_RS22950	COG1136	(ABC) transporter
EXW44_RS22955	COG0577	efflux transmembrane transporter activity
EXW44_RS22970	COG2188	Transcriptional regulator
EXW44_RS22990	COG3964	amidohydrolase
EXW44_RS23010	COG4948	Mandelate Racemase Muconate Lactonizing
EXW44_RS23015	COG0318	PFAM AMP-dependent synthetase and ligase
EXW44_RS23025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW44_RS23035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW44_RS23040	COG1169	isochorismate synthase
EXW44_RS23045	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW44_RS23050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW44_RS23055	COG1278	Cold shock
EXW44_RS23065	COG0789	Transcriptional regulator
EXW44_RS23075	COG0058	SHG alpha-glucan phosphorylase activity
EXW44_RS23085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW44_RS23090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW44_RS23095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW44_RS23120	COG1595	DNA-templated transcription, initiation
EXW44_RS23255	COG1285	pathogenesis
EXW44_RS23260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW44_RS23270	COG0166	Belongs to the GPI family
EXW44_RS23275	COG2155	Conserved Protein
EXW44_RS23280	COG1098	S1 RNA binding domain
EXW44_RS23285	COG0436	Aminotransferase
EXW44_RS23290	COG1522	sequence-specific DNA binding
EXW44_RS23295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW44_RS23300	COG2267	carboxylic ester hydrolase activity
EXW44_RS23310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW44_RS23330	COG5018	Exonuclease
EXW44_RS23335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW44_RS23355	COG2050	protein possibly involved in aromatic compounds catabolism
EXW44_RS23365	COG1268	BioY protein
EXW44_RS23375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW44_RS23380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW44_RS23390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW44_RS23395	COG3584	3D domain protein
EXW44_RS23410	COG1252	NADH dehydrogenase
EXW44_RS23415	COG0492	ferredoxin-NADP+ reductase activity
EXW44_RS23420	COG3708	Transcriptional regulator
EXW44_RS23435	COG1683	Conserved Protein
EXW44_RS23455	COG0316	Belongs to the HesB IscA family
EXW44_RS23460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW44_RS23465	COG4844	belongs to the
EXW44_RS23470	COG1252	NADH dehydrogenase
EXW44_RS23480	COG0390	transport system, permease component
EXW44_RS23485	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW44_RS23515	COG4837	Protein of unknown function (DUF1462)
EXW44_RS23520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW44_RS23530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW44_RS23535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW44_RS23550	COG0577	efflux transmembrane transporter activity
EXW44_RS23550	COG1136	(ABC) transporter
EXW44_RS23555	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW44_RS23565	COG0647	UMP catabolic process
EXW44_RS23575	COG2445	Protein of unknown function DUF86
EXW44_RS23580	COG1494	fructose-1,6-bisphosphatase
EXW44_RS23595	COG4470	Protein conserved in bacteria
EXW44_RS23605	COG0789	Transcriptional regulator
EXW44_RS23610	COG4377	Putative membrane peptidase family (DUF2324)
EXW44_RS23630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW44_RS23635	COG0739	heme binding
EXW44_RS23645	COG3377	Domain of unknown function (DUF1805)
EXW44_RS23650	COG0737	Belongs to the 5'-nucleotidase family
EXW44_RS23655	COG1695	Transcriptional regulator
EXW44_RS23665	COG0719	Fe-S assembly protein
EXW44_RS23670	COG0822	iron-sulfur transferase activity
EXW44_RS23675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW44_RS23680	COG0719	Fe-S assembly protein
EXW44_RS23685	COG0396	ATPase activity
EXW44_RS23690	COG1464	Belongs to the NlpA lipoprotein family
EXW44_RS23695	COG1464	Belongs to the NlpA lipoprotein family
EXW44_RS23700	COG2011	ABC-type metal ion transport system permease component
EXW44_RS23705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW44_RS23715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW44_RS23720	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW44_RS23730	COG0509	glycine decarboxylation via glycine cleavage system
EXW44_RS23735	COG1393	Belongs to the ArsC family
EXW44_RS23770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW44_RS23775	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS23780	COG0183	Belongs to the thiolase family
EXW44_RS23785	COG1024	Enoyl-CoA hydratase
EXW44_RS23785	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW44_RS23795	COG1686	Belongs to the peptidase S11 family
EXW44_RS23800	COG0506	proline dehydrogenase activity
EXW44_RS23810	COG0011	TIGRFAM Protein of
EXW44_RS23815	COG0840	transmembrane signaling receptor activity
EXW44_RS23830	COG2814	Major facilitator Superfamily
EXW44_RS23835	COG0531	amino acid
EXW44_RS23860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS23900	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS23910	COG1376	ErfK ybiS ycfS ynhG family protein
EXW44_RS23915	COG0745	RESPONSE REGULATOR receiver
EXW44_RS23920	COG5002	protein histidine kinase activity
EXW44_RS23930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW44_RS23945	COG0840	transmembrane signaling receptor activity
EXW44_RS23950	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW44_RS23955	COG3227	Zinc metalloprotease (Elastase)
EXW44_RS23960	COG1741	Belongs to the pirin family
EXW44_RS23975	COG0586	Pfam SNARE associated Golgi protein
EXW44_RS23980	COG0475	glutathione-regulated potassium exporter activity
EXW44_RS23985	COG0490	domain, Protein
EXW44_RS23990	COG1115	amino acid carrier protein
EXW44_RS23995	COG0783	Belongs to the Dps family
EXW44_RS24005	COG2318	DinB family
EXW44_RS24010	COG1611	Belongs to the LOG family
EXW44_RS24020	COG1528	Iron-storage protein
EXW44_RS24025	COG2311	Membrane
EXW44_RS24030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS24035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS24040	COG1115	amino acid carrier protein
EXW44_RS24045	COG2910	NAD(P)H-binding
EXW44_RS24060	COG0656	L-ascorbic acid biosynthetic process
EXW44_RS24065	COG2814	Major facilitator Superfamily
EXW44_RS24070	COG1733	regulation of RNA biosynthetic process
EXW44_RS24080	COG1252	NADH dehydrogenase
EXW44_RS24100	COG0840	transmembrane signaling receptor activity
EXW44_RS24100	COG3290	protein histidine kinase activity
EXW44_RS24110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW44_RS24130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW44_RS24145	COG4224	UPF0291 protein
EXW44_RS24150	COG1335	isochorismatase
EXW44_RS24155	COG1522	sequence-specific DNA binding
EXW44_RS24165	COG1522	sequence-specific DNA binding
EXW44_RS24170	COG0288	reversible hydration of carbon dioxide
EXW44_RS24175	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW44_RS24180	COG2233	PERMEase
EXW44_RS24220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW44_RS24225	COG0557	exoribonuclease II activity
EXW44_RS24230	COG1647	Serine aminopeptidase, S33
EXW44_RS24235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW44_RS24240	COG1346	cytolysis
EXW44_RS24255	COG0148	phosphopyruvate hydratase activity
EXW44_RS24265	COG0149	triose-phosphate isomerase activity
EXW44_RS24270	COG0126	phosphoglycerate kinase activity
EXW44_RS24275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW44_RS24290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW44_RS24325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW44_RS24340	COG2323	membrane
EXW44_RS24350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW44_RS24355	COG1481	regulation of sporulation
EXW44_RS24360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW44_RS24365	COG1660	Displays ATPase and GTPase activities
EXW44_RS24370	COG1051	belongs to the nudix hydrolase family
EXW44_RS24380	COG0492	ferredoxin-NADP+ reductase activity
EXW44_RS24385	COG0457	Tetratricopeptide repeat
EXW44_RS24390	COG0110	maltose O-acetyltransferase activity
EXW44_RS24395	COG0546	phosphoglycolate phosphatase activity
EXW44_RS24400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW44_RS24405	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW44_RS24410	COG1950	PFAM Membrane protein of
EXW44_RS24415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW44_RS24435	COG0789	Transcriptional regulator
EXW44_RS24470	COG0583	DNA-binding transcription factor activity
EXW44_RS24475	COG0789	Transcriptional regulator
EXW44_RS24480	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW44_RS24485	COG0488	(ABC) transporter
EXW44_RS24495	COG1132	(ABC) transporter
EXW44_RS24500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW44_RS24505	COG0793	Belongs to the peptidase S41A family
EXW44_RS24505	COG3409	Peptidoglycan-binding domain 1 protein
EXW44_RS24510	COG2177	Part of the ABC transporter FtsEX involved in
EXW44_RS24515	COG2884	Cell division ATP-binding protein ftsE
EXW44_RS24540	COG1131	(ABC) transporter
EXW44_RS24575	COG1278	Cold shock
EXW44_RS24580	COG1040	competence protein
EXW44_RS24585	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW44_RS24590	COG0791	NLP P60 protein
EXW44_RS24590	COG1388	LysM domain
EXW44_RS24595	COG1733	regulation of RNA biosynthetic process
EXW44_RS24600	COG1307	EDD domain protein, DegV family
EXW44_RS24605	COG1739	Uncharacterized protein family UPF0029
EXW44_RS24610	COG1316	TRANSCRIPTIONal
EXW44_RS24615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW44_RS24620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW44_RS24625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW44_RS24635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW44_RS24635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW44_RS24655	COG1486	melibiose metabolic process
EXW44_RS24660	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW44_RS24665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW44_RS24685	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW44_RS24695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW44_RS24700	COG1301	dicarboxylic acid transport
EXW44_RS24715	COG1511	domain protein
EXW44_RS24720	COG0583	DNA-binding transcription factor activity
EXW44_RS24725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW44_RS24735	COG1271	oxidase subunit
EXW44_RS24740	COG1294	oxidase, subunit
EXW44_RS24745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW44_RS24750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW44_RS24755	COG1620	l-lactate permease
EXW44_RS24765	COG2389	metal-binding protein
EXW44_RS24775	COG1368	sulfuric ester hydrolase activity
EXW44_RS24785	COG1388	LysM domain
EXW44_RS24785	COG0791	NLP P60 protein
EXW44_RS24790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW44_RS24800	COG1215	transferase activity, transferring glycosyl groups
EXW44_RS24805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW44_RS24810	COG1388	LysM domain
EXW44_RS24810	COG3584	3D domain protein
EXW44_RS24835	COG4715	Zinc finger, swim domain protein
EXW44_RS24840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW44_RS24880	COG0577	efflux transmembrane transporter activity
EXW44_RS24885	COG1136	(ABC) transporter
EXW44_RS24920	COG3850	Histidine kinase
EXW44_RS24920	COG5002	protein histidine kinase activity
EXW44_RS24925	COG0745	RESPONSE REGULATOR receiver
EXW44_RS24935	COG1316	TRANSCRIPTIONal
EXW44_RS24945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW44_RS24965	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS24975	COG1215	transferase activity, transferring glycosyl groups
EXW44_RS24985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW44_RS24990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW44_RS24995	COG1086	Polysaccharide biosynthesis protein
EXW44_RS25000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW44_RS25005	COG4464	protein tyrosine phosphatase activity
EXW44_RS25010	COG0489	protein tyrosine kinase activity
EXW44_RS25015	COG3944	biosynthesis protein
EXW44_RS25020	COG0489	protein tyrosine kinase activity
EXW44_RS25035	COG1609	Transcriptional regulator
EXW44_RS25045	COG0739	heme binding
EXW44_RS25060	COG3279	Response regulator of the LytR AlgR family
EXW44_RS25065	COG2385	sporulation resulting in formation of a cellular spore
EXW44_RS25080	COG4836	Membrane
EXW44_RS25085	COG1007	ATP synthesis coupled electron transport
EXW44_RS25090	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW44_RS25095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW44_RS25100	COG0713	ATP synthesis coupled electron transport
EXW44_RS25105	COG0839	Belongs to the complex I subunit 6 family
EXW44_RS25115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW44_RS25120	COG0649	NAD binding
EXW44_RS25125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW44_RS25130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW44_RS25135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW44_RS25140	COG5001	Diguanylate cyclase
EXW44_RS25140	COG3300	MHYT domain
EXW44_RS25155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW44_RS25160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW44_RS25165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW44_RS25170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW44_RS25175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW44_RS25180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW44_RS25190	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW44_RS25215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW44_RS25225	COG0698	ribose 5-phosphate isomerase
EXW44_RS25235	COG2190	(PTS) system
EXW44_RS25240	COG2259	Doxx family
EXW44_RS25245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW44_RS25255	COG1971	Probably functions as a manganese efflux pump
EXW44_RS25260	COG0009	L-threonylcarbamoyladenylate synthase
EXW44_RS25275	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW44_RS25280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW44_RS25285	COG1435	thymidine kinase activity
EXW44_RS25295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW44_RS25300	COG1494	fructose-1,6-bisphosphatase
EXW44_RS25320	COG4821	SIS domain
EXW44_RS25325	COG0504	CTP synthase activity
EXW44_RS25330	COG3343	RNA polymerase activity
EXW44_RS25340	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS25345	COG1960	acyl-CoA dehydrogenase activity
EXW44_RS25350	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW44_RS25355	COG0183	Belongs to the thiolase family
EXW44_RS25360	COG0247	lactate metabolic process
EXW44_RS25360	COG2181	nitrate reductase activity
EXW44_RS25365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW44_RS25370	COG4294	response to UV
EXW44_RS25375	COG3300	MHYT domain
EXW44_RS25375	COG5001	Diguanylate cyclase
EXW44_RS25390	COG3227	Zinc metalloprotease (Elastase)
EXW44_RS25395	COG2197	response regulator
EXW44_RS25400	COG4585	Histidine kinase
EXW44_RS25405	COG0842	Transport permease protein
EXW44_RS25410	COG1131	(ABC) transporter
EXW44_RS25415	COG0024	Methionine aminopeptidase
EXW44_RS25420	COG2234	aminopeptidase activity
EXW44_RS25435	COG4506	Protein conserved in bacteria
EXW44_RS25440	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW44_RS25455	COG0010	Belongs to the arginase family
EXW44_RS25460	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW44_RS25465	COG2814	Major facilitator Superfamily
EXW44_RS25470	COG0789	Transcriptional regulator
EXW44_RS25475	COG0584	glycerophosphoryl diester phosphodiesterase
EXW44_RS25480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW44_RS25490	COG1994	Peptidase M50
EXW44_RS25500	COG1078	dGTPase activity
EXW44_RS25505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW44_RS25510	COG1120	ATPase activity
EXW44_RS25515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS25520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW44_RS25525	COG4844	belongs to the
EXW44_RS25540	COG0280	phosphate acetyltransferase
EXW44_RS25545	COG3253	May function as heme-dependent peroxidase
EXW44_RS25555	COG3773	Cell wall hydrolase
EXW44_RS25565	COG2363	Small membrane protein
EXW44_RS25580	COG2233	PERMEase
EXW44_RS25585	COG0561	phosphatase activity
EXW44_RS25590	COG2814	Major facilitator Superfamily
EXW44_RS25595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW44_RS25600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW44_RS25605	COG1131	(ABC) transporter
EXW44_RS25610	COG2755	lipolytic protein G-D-S-L family
EXW44_RS25615	COG1609	Transcriptional regulator
EXW44_RS25625	COG0460	homoserine dehydrogenase
EXW44_RS25630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW44_RS25635	COG2873	o-acetylhomoserine
EXW44_RS25650	COG2197	response regulator
EXW44_RS25655	COG4585	Histidine kinase
EXW44_RS25655	COG2203	Gaf domain
EXW44_RS25660	COG0351	phosphomethylpyrimidine kinase
EXW44_RS25665	COG3706	GGDEF domain
EXW44_RS25670	COG2879	small protein
EXW44_RS25675	COG1966	Carbon starvation protein
EXW44_RS25680	COG3279	Response regulator of the LytR AlgR family
EXW44_RS25685	COG0477	Major facilitator Superfamily
EXW44_RS25710	COG0840	transmembrane signaling receptor activity
EXW44_RS25720	COG1607	acyl-coa hydrolase
EXW44_RS25725	COG1216	Glycosyl transferase, family 2
EXW44_RS25735	COG1216	Glycosyl transferase, family 2
EXW44_RS25745	COG4485	Bacterial membrane protein, YfhO
EXW44_RS25750	COG0463	Glycosyl transferase, family 2
EXW44_RS25760	COG1309	transcriptional regulator
EXW44_RS25765	COG0488	(ABC) transporter
EXW44_RS25770	COG1309	transcriptional regulator
EXW44_RS25775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW44_RS25780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW44_RS25780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW44_RS25785	COG0628	permease
EXW44_RS25795	COG1380	Effector of murein hydrolase LrgA
EXW44_RS25800	COG3279	Response regulator of the LytR AlgR family
EXW44_RS25805	COG3275	phosphorelay sensor kinase activity
EXW44_RS25810	COG2814	Major facilitator Superfamily
EXW44_RS25815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW44_RS25820	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW44_RS25825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW44_RS25875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW44_RS25880	COG1272	protein, Hemolysin III
EXW44_RS25905	COG1164	Oligoendopeptidase f
EXW44_RS25915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW44_RS25925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW44_RS25930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW44_RS25935	COG4853	Protein conserved in bacteria
EXW44_RS25945	COG5002	protein histidine kinase activity
EXW44_RS25950	COG0745	RESPONSE REGULATOR receiver
EXW44_RS25980	COG0305	Participates in initiation and elongation during chromosome replication
EXW44_RS25985	COG0359	binds to the 23S rRNA
EXW44_RS25990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW44_RS25995	COG4241	membrane
EXW44_RS26005	COG0629	single-stranded DNA binding
EXW44_RS26010	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW44_RS26015	COG0012	GTP binding
EXW44_RS26020	COG4481	Protein conserved in bacteria
EXW44_RS26025	COG0668	transmembrane transport
EXW44_RS26035	COG1475	DNA binding
EXW44_RS26040	COG1192	Involved in chromosome partitioning
EXW44_RS26045	COG1475	DNA binding
EXW44_RS26050	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW44_RS26055	COG0445	tRNA wobble uridine modification
EXW44_RS26060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW44_RS26065	COG1847	R3H domain protein
EXW44_RS26070	COG0706	membrane insertase activity
EXW44_RS26075	COG0594	ribonuclease P activity
EXW44_RS26080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW44_RS26085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW44_RS26090	COG0592	DNA-directed DNA polymerase activity
EXW44_RS26095	COG2501	S4 domain
EXW44_RS26100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW44_RS26105	COG0187	DNA topoisomerase II activity
EXW44_RS26110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW44_RS26145	COG0516	GMP reductase activity
EXW44_RS26145	COG0517	IMP dehydrogenase activity
EXW44_RS26150	COG1686	Belongs to the peptidase S11 family
EXW44_RS26155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW44_RS26160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW44_RS26180	COG1428	Deoxynucleoside kinase
EXW44_RS26185	COG1428	Deoxynucleoside kinase
EXW44_RS26190	COG1335	isochorismatase
EXW44_RS26195	COG0590	tRNA wobble adenosine to inosine editing
EXW44_RS26205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW44_RS26210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW44_RS26215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW44_RS26260	COG1982	Orn Lys Arg decarboxylase major
EXW44_RS26265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW44_RS26270	COG0470	DNA polymerase III
EXW44_RS26275	COG1774	PSP1 C-terminal conserved region
EXW44_RS26280	COG4467	Involved in initiation control of chromosome replication
EXW44_RS26285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW44_RS26295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW44_RS26300	COG2002	toxin-antitoxin pair type II binding
EXW44_RS26310	COG0084	hydrolase, TatD family'
EXW44_RS26320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW44_RS26330	COG4466	Protein conserved in bacteria
EXW44_RS26340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW44_RS26345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW44_RS26350	COG0251	oxidation-reduction process
EXW44_RS26355	COG2088	sporulation resulting in formation of a cellular spore
EXW44_RS26360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW44_RS26380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW44_RS26385	COG2002	toxin-antitoxin pair type II binding
EXW44_RS26390	COG2244	polysaccharide biosynthetic process
EXW44_RS26395	COG3956	TIGRFAM MazG family protein
EXW44_RS26400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW44_RS26420	COG1098	S1 RNA binding domain
EXW44_RS26435	COG2208	phosphoserine phosphatase activity
EXW44_RS26445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW44_RS26450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW44_RS26455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW44_RS26460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW44_RS26465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW44_RS26470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW44_RS26475	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW44_RS26480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW44_RS26485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW44_RS26490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW44_RS26495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW44_RS26500	COG1396	sequence-specific DNA binding
EXW44_RS26505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW44_RS26510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW44_RS26595	COG3880	PFAM UvrB UvrC protein
EXW44_RS26600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW44_RS26605	COG0542	response to heat
EXW44_RS26610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW44_RS26615	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW44_RS26620	COG4956	integral membrane protein (PIN domain superfamily)
EXW44_RS26625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW44_RS26635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW44_RS26640	COG1045	serine acetyltransferase
EXW44_RS26645	COG0215	cysteine-tRNA ligase activity
EXW44_RS26655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW44_RS26660	COG3688	RNA-binding protein containing a PIN domain
EXW44_RS26670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW44_RS26675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW44_RS26680	COG0250	Participates in transcription elongation, termination and antitermination
EXW44_RS26685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW44_RS26690	COG0081	regulation of translation
EXW44_RS26695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW44_RS26700	COG0222	ribosome binding
EXW44_RS26705	COG2813	Specifically methylates the guanine in position
EXW44_RS26710	COG0085	RNA polymerase activity
EXW44_RS26715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW44_RS26720	COG1358	cellular component organization or biogenesis
EXW44_RS26725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW44_RS26735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW44_RS26740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW44_RS26745	COG0051	transcription antitermination factor activity, RNA binding
EXW44_RS26750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW44_RS26755	COG0088	Forms part of the polypeptide exit tunnel
EXW44_RS26760	COG0089	rRNA binding
EXW44_RS26765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW44_RS26770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW44_RS26775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW44_RS26790	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW44_RS26795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW44_RS26805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW44_RS26810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW44_RS26820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW44_RS26830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW44_RS26840	COG1841	ribosomal large subunit assembly
EXW44_RS26845	COG0200	Binds to the 23S rRNA
EXW44_RS26850	COG0201	protein transport
EXW44_RS26855	COG0563	adenylate kinase activity
EXW44_RS26860	COG0024	Methionine aminopeptidase
EXW44_RS26870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW44_RS26875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW44_RS26880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW44_RS26905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW44_RS26915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW44_RS26920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW44_RS26930	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW44_RS26935	COG0489	protein tyrosine kinase activity
EXW44_RS26945	COG2194	sulfuric ester hydrolase activity
EXW44_RS26950	COG0726	polysaccharide deacetylase
EXW44_RS27030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW44_RS27035	COG4856	YbbR-like protein
EXW44_RS27040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW44_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS27070	COG2011	ABC-type metal ion transport system permease component
EXW44_RS27080	COG1464	Belongs to the NlpA lipoprotein family
EXW44_RS27085	COG0604	alcohol dehydrogenase
EXW44_RS27095	COG0277	FAD linked oxidase domain protein
EXW44_RS27100	COG2271	Major facilitator Superfamily
EXW44_RS27110	COG2814	Major facilitator Superfamily
EXW44_RS27125	COG0601	transmembrane transport
EXW44_RS27130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW44_RS27135	COG0444	Belongs to the ABC transporter superfamily
EXW44_RS27140	COG4608	Belongs to the ABC transporter superfamily
EXW44_RS27145	COG4166	transmembrane transport
EXW44_RS27170	COG4166	transmembrane transport
EXW44_RS27175	COG4166	transmembrane transport
EXW44_RS27180	COG0656	L-ascorbic acid biosynthetic process
EXW44_RS27200	COG4149	molybdate abc transporter
EXW44_RS27205	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW44_RS27210	COG1910	domain protein
EXW44_RS27225	COG0697	spore germination
EXW44_RS27240	COG0204	Acyl-transferase
EXW44_RS27250	COG1609	Transcriptional regulator
EXW44_RS27260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW44_RS27275	COG5298	Protein conserved in bacteria
EXW44_RS27295	COG0488	(ABC) transporter
EXW44_RS27300	COG4585	Histidine kinase
EXW44_RS27305	COG2197	response regulator
EXW44_RS27310	COG1131	(ABC) transporter
EXW44_RS27315	COG1511	domain protein
EXW44_RS27315	COG0842	Transport permease protein
EXW44_RS27320	COG0842	Transport permease protein
EXW44_RS27330	COG0747	negative chemotaxis
EXW44_RS27340	COG0601	transmembrane transport
EXW44_RS27345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW44_RS27350	COG0444	Belongs to the ABC transporter superfamily
EXW44_RS27355	COG4608	Belongs to the ABC transporter superfamily
EXW44_RS27360	COG0561	phosphatase activity
EXW44_RS27390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW44_RS27395	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW44_RS27405	COG0531	amino acid
EXW44_RS27410	COG2814	Major facilitator Superfamily
EXW44_RS27420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW44_RS27430	COG4294	response to UV
EXW44_RS27435	COG0705	Rhomboid family
EXW44_RS27440	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW44_RS27445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW44_RS27455	COG0864	Transcriptional regulator
EXW44_RS27460	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW44_RS27465	COG2183	response to ionizing radiation
EXW44_RS27565	COG0802	atpase or kinase
EXW44_RS27570	COG1214	PFAM Peptidase M22, glycoprotease
EXW44_RS27575	COG0456	acetyltransferase
EXW44_RS27585	COG0488	(ABC) transporter
EXW44_RS27590	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW44_RS27600	COG1266	CAAX protease self-immunity
EXW44_RS27605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW44_RS27610	COG0459	protein refolding
EXW44_RS27615	COG0519	Catalyzes the synthesis of GMP from XMP
EXW44_RS27615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW44_RS27620	COG2252	PERMEase
EXW44_RS27630	COG5002	protein histidine kinase activity
EXW44_RS27660	COG1028	Short-chain dehydrogenase reductase Sdr
EXW44_RS27715	COG0673	inositol 2-dehydrogenase activity
EXW44_RS27720	COG0673	inositol 2-dehydrogenase activity
EXW44_RS27725	COG2169	Transcriptional regulator
EXW44_RS27960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW44_RS27970	COG0662	Cupin 2, conserved barrel domain protein
EXW44_RS27970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EXW44_RS28040	COG3344	reverse transcriptase
EXW44_RS28065	COG2311	Membrane
EXW44_RS28095	COG1696	Membrane protein involved in D-alanine export
EXW44_RS28110	COG0745	RESPONSE REGULATOR receiver
EXW44_RS28130	COG1279	arginine transmembrane transporter activity
EXW44_RS28135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW44_RS28140	COG1175	transmembrane transport
EXW44_RS28145	COG0395	ABC-type sugar transport system, permease component
EXW44_RS28170	COG3842	ATPase activity
EXW44_RS28175	COG5002	protein histidine kinase activity
EXW44_RS28185	COG1136	(ABC) transporter
EXW44_RS28200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW44_RS28210	COG2707	UPF0756 membrane protein
EXW44_RS28220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW44_RS28350	COG2814	Major facilitator Superfamily
EXW44_RS28480	COG4977	sequence-specific DNA binding
EXW44_RS28495	COG0083	homoserine kinase activity
EXW44_RS28510	COG1309	transcriptional regulator
EXW44_RS28515	COG2814	Major facilitator Superfamily
EXW44_RS28525	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW44_RS28525	COG2508	Transcriptional regulator
EXW44_RS28530	COG0686	Belongs to the AlaDH PNT family
EXW44_RS28595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW44_RS28645	COG1396	sequence-specific DNA binding
EXW44_RS28665	COG0840	transmembrane signaling receptor activity
EXW44_RS28670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW44_RS28690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW44_RS28695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW44_RS28700	COG0772	Belongs to the SEDS family
EXW44_RS28705	COG2239	Acts as a magnesium transporter
EXW44_RS28715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW44_RS28725	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW44_RS28730	COG0519	Catalyzes the synthesis of GMP from XMP
EXW44_RS28740	COG1278	Cold shock
EXW44_RS28760	COG0024	Methionine aminopeptidase
EXW44_RS28795	COG4974	Belongs to the 'phage' integrase family
EXW44_RS28880	COG2357	RelA SpoT domain protein
EXW44_RS28885	COG2814	Major facilitator Superfamily
EXW44_RS28940	COG0776	regulation of translation
EXW44_RS28980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW44_RS29000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW44_RS29025	COG3344	reverse transcriptase
EXW44_RS29085	COG0640	Transcriptional regulator
EXW44_RS29100	COG0457	Tetratricopeptide repeat
EXW44_RS29155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW44_RS29160	COG2040	homocysteine
EXW44_RS29165	COG0833	amino acid
EXW44_RS29265	COG1725	Transcriptional regulator
EXW44_RS29270	COG1131	(ABC) transporter
EXW44_RS29305	COG1329	Transcriptional regulator
EXW44_RS29375	COG0457	Tetratricopeptide repeat
EXW44_RS29405	COG1132	(ABC) transporter
EXW44_RS29455	COG1396	sequence-specific DNA binding
EXW44_RS29475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW44_RS29505	COG0653	protein targeting
EXW44_RS29605	COG0367	asparagine synthase
EXW44_RS29680	COG0542	response to heat
EXW44_RS29690	COG3397	chitin binding
EXW44_RS29770	COG1132	(ABC) transporter
EXW44_RS29820	COG1404	Belongs to the peptidase S8 family
EXW44_RS29830	COG2814	Major facilitator Superfamily
EXW44_RS29835	COG2234	aminopeptidase activity
EXW44_RS29845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW44_RS29860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW44_RS29865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW44_RS29870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW44_RS29880	COG0456	acetyltransferase
EXW44_RS29915	COG1956	GAF domain-containing protein
EXW44_RS29995	COG0551	DNA topoisomerase type I activity
EXW44_RS29995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW44_RS30065	COG1388	LysM domain
EXW44_RS30115	COG0463	Glycosyl transferase, family 2
EXW44_RS30135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW44_RS30140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW44_RS30145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW44_RS30150	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS30165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW44_RS30170	COG0438	transferase activity, transferring glycosyl groups
EXW44_RS30175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW44_RS30260	COG3773	Cell wall hydrolase
EXW44_RS30315	COG4166	transmembrane transport
EXW44_RS30380	COG0582	viral genome integration into host DNA
EXW44_RS30390	COG3620	sequence-specific DNA binding
EXW44_RS30405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW44_RS30675	COG2076	Multidrug Resistance protein
EXW44_RS30880	COG0561	phosphatase activity