locus-tag	class	description
EXW59_RS00050	COG2002	toxin-antitoxin pair type II binding
EXW59_RS00075	COG0457	Tetratricopeptide repeat
EXW59_RS00085	COG0582	viral genome integration into host DNA
EXW59_RS00105	COG0741	lytic transglycosylase activity
EXW59_RS00105	COG0791	NLP P60 protein
EXW59_RS00110	COG5644	endopeptidase inhibitor activity
EXW59_RS00120	COG0433	COG0433 Predicted ATPase
EXW59_RS00185	COG1136	(ABC) transporter
EXW59_RS00305	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_RS00370	COG5002	protein histidine kinase activity
EXW59_RS00375	COG0745	RESPONSE REGULATOR receiver
EXW59_RS00385	COG3335	DDE superfamily endonuclease
EXW59_RS00395	COG0577	efflux transmembrane transporter activity
EXW59_RS00400	COG1136	(ABC) transporter
EXW59_RS00420	COG2801	Transposase and inactivated derivatives
EXW59_RS00430	COG0582	viral genome integration into host DNA
EXW59_RS00450	COG2002	toxin-antitoxin pair type II binding
EXW59_RS00575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS00585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_RS00590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_RS00600	COG0697	spore germination
EXW59_RS00610	COG2002	toxin-antitoxin pair type II binding
EXW59_RS00645	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS00650	COG1115	amino acid carrier protein
EXW59_RS00685	COG0776	regulation of translation
EXW59_RS00740	COG2002	toxin-antitoxin pair type II binding
EXW59_RS00745	COG1923	regulation of RNA biosynthetic process
EXW59_RS00925	COG0697	spore germination
EXW59_RS00945	COG4644	lycopene metabolic process
EXW59_RS01025	COG3344	reverse transcriptase
EXW59_RS01120	COG3344	reverse transcriptase
EXW59_RS01185	COG1192	Involved in chromosome partitioning
EXW59_RS01370	COG2323	membrane
EXW59_RS01410	COG0673	inositol 2-dehydrogenase activity
EXW59_RS01415	COG0673	inositol 2-dehydrogenase activity
EXW59_RS01420	COG2169	Transcriptional regulator
EXW59_RS01445	COG1674	ftsk spoiiie
EXW59_RS01445	COG4980	gas vesicle protein
EXW59_RS01680	COG2311	Membrane
EXW59_RS01745	COG3344	reverse transcriptase
EXW59_RS01785	COG0463	Glycosyl transferase, family 2
EXW59_RS01790	COG0463	Glycosyl transferase, family 2
EXW59_RS01795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW59_RS01800	COG1086	Polysaccharide biosynthesis protein
EXW59_RS01805	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW59_RS01810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_RS01815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW59_RS01830	COG2089	acid synthase
EXW59_RS01835	COG4641	Protein conserved in bacteria
EXW59_RS01900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS01900	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_RS01915	COG1136	(ABC) transporter
EXW59_RS01940	COG0662	Cupin 2, conserved barrel domain protein
EXW59_RS01975	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_RS01980	COG3711	transcriptional antiterminator
EXW59_RS01985	COG1263	PTS System
EXW59_RS01985	COG2190	(PTS) system
EXW59_RS01985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS01990	COG2723	6-phospho-beta-galactosidase activity
EXW59_RS02005	COG2239	Acts as a magnesium transporter
EXW59_RS02040	COG0697	spore germination
EXW59_RS02050	COG1252	NADH dehydrogenase
EXW59_RS02055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS02055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS02060	COG2002	toxin-antitoxin pair type II binding
EXW59_RS02075	COG1923	regulation of RNA biosynthetic process
EXW59_RS02110	COG2814	Major facilitator Superfamily
EXW59_RS02180	COG2002	toxin-antitoxin pair type II binding
EXW59_RS02195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW59_RS02275	COG1923	regulation of RNA biosynthetic process
EXW59_RS02305	COG4974	Belongs to the 'phage' integrase family
EXW59_RS02310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_RS02325	COG2076	Multidrug Resistance protein
EXW59_RS02330	COG2076	Multidrug Resistance protein
EXW59_RS02335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW59_RS02340	COG1073	alpha beta
EXW59_RS02345	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW59_RS02350	COG0772	Belongs to the SEDS family
EXW59_RS02355	COG2239	Acts as a magnesium transporter
EXW59_RS02365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_RS02375	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW59_RS02390	COG0745	RESPONSE REGULATOR receiver
EXW59_RS02425	COG1846	Transcriptional regulator
EXW59_RS02430	COG2814	Major facilitator Superfamily
EXW59_RS02450	COG4974	Belongs to the 'phage' integrase family
EXW59_RS02455	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS02540	COG0745	RESPONSE REGULATOR receiver
EXW59_RS02550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_RS02565	COG2040	homocysteine
EXW59_RS02570	COG0833	amino acid
EXW59_RS02585	COG1942	4-Oxalocrotonate Tautomerase
EXW59_RS02590	COG0583	DNA-binding transcription factor activity
EXW59_RS02600	COG1846	Transcriptional regulator
EXW59_RS02610	COG1136	(ABC) transporter
EXW59_RS02615	COG0577	efflux transmembrane transporter activity
EXW59_RS02625	COG0741	lytic transglycosylase activity
EXW59_RS02650	COG1674	ftsk spoiiie
EXW59_RS02665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW59_RS02685	COG1533	DNA photolyase activity
EXW59_RS02720	COG2155	Conserved Protein
EXW59_RS02735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_RS02800	COG0756	dUTP diphosphatase activity
EXW59_RS02850	COG1329	Transcriptional regulator
EXW59_RS02875	COG2814	Major facilitator Superfamily
EXW59_RS02880	COG0583	DNA-binding transcription factor activity
EXW59_RS02900	COG0577	efflux transmembrane transporter activity
EXW59_RS02905	COG1136	(ABC) transporter
EXW59_RS02925	COG0463	Glycosyl transferase, family 2
EXW59_RS02930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EXW59_RS02935	COG0745	RESPONSE REGULATOR receiver
EXW59_RS02940	COG5002	protein histidine kinase activity
EXW59_RS02965	COG0640	Transcriptional regulator
EXW59_RS02990	COG1329	Transcriptional regulator
EXW59_RS03000	COG0456	acetyltransferase
EXW59_RS03020	COG4176	ABC-type proline glycine betaine transport system permease component
EXW59_RS03025	COG0517	IMP dehydrogenase activity
EXW59_RS03025	COG4175	Glycine betaine
EXW59_RS03120	COG0457	Tetratricopeptide repeat
EXW59_RS03250	COG0697	spore germination
EXW59_RS03280	COG0457	Tetratricopeptide repeat
EXW59_RS03350	COG1396	sequence-specific DNA binding
EXW59_RS03390	COG0326	Molecular chaperone. Has ATPase activity
EXW59_RS03410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW59_RS03490	COG0367	asparagine synthase
EXW59_RS03545	COG0542	response to heat
EXW59_RS03550	COG3397	chitin binding
EXW59_RS03635	COG1404	Belongs to the peptidase S8 family
EXW59_RS03655	COG2814	Major facilitator Superfamily
EXW59_RS03660	COG2234	aminopeptidase activity
EXW59_RS03670	COG0363	glucosamine-6-phosphate deaminase activity
EXW59_RS03685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_RS03690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_RS03695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_RS03705	COG0456	acetyltransferase
EXW59_RS03730	COG1278	Cold shock
EXW59_RS03755	COG1695	Transcriptional regulator
EXW59_RS03815	COG2002	toxin-antitoxin pair type II binding
EXW59_RS03820	COG1923	regulation of RNA biosynthetic process
EXW59_RS03880	COG0697	spore germination
EXW59_RS03895	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_RS03930	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_RS03935	COG0288	reversible hydration of carbon dioxide
EXW59_RS04075	COG0457	Tetratricopeptide repeat
EXW59_RS04165	COG0791	NLP P60 protein
EXW59_RS04165	COG0741	lytic transglycosylase activity
EXW59_RS04275	COG0457	Tetratricopeptide repeat
EXW59_RS04280	COG0457	Tetratricopeptide repeat
EXW59_RS04365	COG1923	regulation of RNA biosynthetic process
EXW59_RS04385	COG2368	4-hydroxyphenylacetate
EXW59_RS04405	COG2873	o-acetylhomoserine
EXW59_RS04500	COG0433	COG0433 Predicted ATPase
EXW59_RS04510	COG5644	endopeptidase inhibitor activity
EXW59_RS04515	COG0791	NLP P60 protein
EXW59_RS04515	COG0741	lytic transglycosylase activity
EXW59_RS04535	COG0582	viral genome integration into host DNA
EXW59_RS04545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW59_RS04550	COG0592	DNA-directed DNA polymerase activity
EXW59_RS04555	COG2501	S4 domain
EXW59_RS04560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW59_RS04565	COG0187	DNA topoisomerase II activity
EXW59_RS04570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW59_RS04605	COG0516	GMP reductase activity
EXW59_RS04605	COG0517	IMP dehydrogenase activity
EXW59_RS04610	COG1686	Belongs to the peptidase S11 family
EXW59_RS04615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW59_RS04620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW59_RS04640	COG1428	Deoxynucleoside kinase
EXW59_RS04645	COG1428	Deoxynucleoside kinase
EXW59_RS04650	COG1335	isochorismatase
EXW59_RS04655	COG0590	tRNA wobble adenosine to inosine editing
EXW59_RS04665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW59_RS04670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW59_RS04675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW59_RS04720	COG1982	Orn Lys Arg decarboxylase major
EXW59_RS04725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW59_RS04730	COG0470	DNA polymerase III
EXW59_RS04735	COG1774	PSP1 C-terminal conserved region
EXW59_RS04740	COG4467	Involved in initiation control of chromosome replication
EXW59_RS04745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW59_RS04755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW59_RS04760	COG2002	toxin-antitoxin pair type II binding
EXW59_RS04770	COG0084	hydrolase, TatD family'
EXW59_RS04780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW59_RS04790	COG4466	Protein conserved in bacteria
EXW59_RS04800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW59_RS04805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_RS04810	COG0251	oxidation-reduction process
EXW59_RS04815	COG2088	sporulation resulting in formation of a cellular spore
EXW59_RS04820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW59_RS04840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW59_RS04845	COG2002	toxin-antitoxin pair type II binding
EXW59_RS04850	COG2244	polysaccharide biosynthetic process
EXW59_RS04855	COG3956	TIGRFAM MazG family protein
EXW59_RS04860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW59_RS04880	COG1098	S1 RNA binding domain
EXW59_RS04895	COG2208	phosphoserine phosphatase activity
EXW59_RS04905	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW59_RS04910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW59_RS04915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW59_RS04920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW59_RS04925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_RS04930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW59_RS04935	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW59_RS04940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_RS04945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW59_RS04950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW59_RS04955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW59_RS04960	COG1396	sequence-specific DNA binding
EXW59_RS04965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW59_RS04970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW59_RS05055	COG3880	PFAM UvrB UvrC protein
EXW59_RS05060	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW59_RS05065	COG0542	response to heat
EXW59_RS05070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW59_RS05075	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW59_RS05080	COG4956	integral membrane protein (PIN domain superfamily)
EXW59_RS05085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW59_RS05095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW59_RS05100	COG1045	serine acetyltransferase
EXW59_RS05105	COG0215	cysteine-tRNA ligase activity
EXW59_RS05115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW59_RS05120	COG3688	RNA-binding protein containing a PIN domain
EXW59_RS05130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW59_RS05135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW59_RS05140	COG0250	Participates in transcription elongation, termination and antitermination
EXW59_RS05145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW59_RS05150	COG0081	regulation of translation
EXW59_RS05155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW59_RS05160	COG0222	ribosome binding
EXW59_RS05165	COG2813	Specifically methylates the guanine in position
EXW59_RS05170	COG0085	RNA polymerase activity
EXW59_RS05175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW59_RS05180	COG1358	cellular component organization or biogenesis
EXW59_RS05185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW59_RS05195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW59_RS05200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW59_RS05205	COG0051	transcription antitermination factor activity, RNA binding
EXW59_RS05210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW59_RS05215	COG0088	Forms part of the polypeptide exit tunnel
EXW59_RS05220	COG0089	rRNA binding
EXW59_RS05225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW59_RS05230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW59_RS05235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW59_RS05250	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW59_RS05255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW59_RS05265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW59_RS05270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW59_RS05280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW59_RS05290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW59_RS05300	COG1841	ribosomal large subunit assembly
EXW59_RS05305	COG0200	Binds to the 23S rRNA
EXW59_RS05310	COG0201	protein transport
EXW59_RS05315	COG0563	adenylate kinase activity
EXW59_RS05320	COG0024	Methionine aminopeptidase
EXW59_RS05330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW59_RS05335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW59_RS05340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW59_RS05365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW59_RS05375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW59_RS05380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW59_RS05390	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS05395	COG0489	protein tyrosine kinase activity
EXW59_RS05405	COG2194	sulfuric ester hydrolase activity
EXW59_RS05410	COG0726	polysaccharide deacetylase
EXW59_RS05490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW59_RS05495	COG4856	YbbR-like protein
EXW59_RS05500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW59_RS05515	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_RS05515	COG1506	peptidase
EXW59_RS05515	COG4946	Tricorn protease homolog
EXW59_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS05530	COG2011	ABC-type metal ion transport system permease component
EXW59_RS05540	COG1464	Belongs to the NlpA lipoprotein family
EXW59_RS05545	COG0604	alcohol dehydrogenase
EXW59_RS05555	COG0277	FAD linked oxidase domain protein
EXW59_RS05560	COG2271	Major facilitator Superfamily
EXW59_RS05570	COG2814	Major facilitator Superfamily
EXW59_RS05585	COG0601	transmembrane transport
EXW59_RS05590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_RS05595	COG0444	Belongs to the ABC transporter superfamily
EXW59_RS05600	COG4608	Belongs to the ABC transporter superfamily
EXW59_RS05605	COG4166	transmembrane transport
EXW59_RS05615	COG2207	Transcriptional regulator
EXW59_RS05630	COG4166	transmembrane transport
EXW59_RS05635	COG4166	transmembrane transport
EXW59_RS05640	COG0656	L-ascorbic acid biosynthetic process
EXW59_RS05645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_RS05660	COG4149	molybdate abc transporter
EXW59_RS05665	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW59_RS05670	COG1910	domain protein
EXW59_RS05685	COG0697	spore germination
EXW59_RS05700	COG0204	Acyl-transferase
EXW59_RS05710	COG1609	Transcriptional regulator
EXW59_RS05720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS05735	COG5298	Protein conserved in bacteria
EXW59_RS05755	COG0488	(ABC) transporter
EXW59_RS05765	COG0747	negative chemotaxis
EXW59_RS05775	COG0601	transmembrane transport
EXW59_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_RS05785	COG0444	Belongs to the ABC transporter superfamily
EXW59_RS05790	COG4608	Belongs to the ABC transporter superfamily
EXW59_RS05795	COG0561	phosphatase activity
EXW59_RS05825	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW59_RS05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW59_RS05840	COG0531	amino acid
EXW59_RS05845	COG2814	Major facilitator Superfamily
EXW59_RS05855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW59_RS05865	COG4294	response to UV
EXW59_RS05870	COG0705	Rhomboid family
EXW59_RS05875	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW59_RS05880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW59_RS05885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_RS05890	COG0864	Transcriptional regulator
EXW59_RS05895	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW59_RS05900	COG2183	response to ionizing radiation
EXW59_RS06000	COG0802	atpase or kinase
EXW59_RS06005	COG1214	PFAM Peptidase M22, glycoprotease
EXW59_RS06010	COG0456	acetyltransferase
EXW59_RS06020	COG0488	(ABC) transporter
EXW59_RS06025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW59_RS06035	COG1266	CAAX protease self-immunity
EXW59_RS06040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW59_RS06045	COG0459	protein refolding
EXW59_RS06050	COG0519	Catalyzes the synthesis of GMP from XMP
EXW59_RS06050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW59_RS06055	COG2252	PERMEase
EXW59_RS06065	COG5002	protein histidine kinase activity
EXW59_RS06090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW59_RS06120	COG2226	methyltransferase
EXW59_RS06140	COG1215	transferase activity, transferring glycosyl groups
EXW59_RS06165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS06170	COG0506	proline dehydrogenase activity
EXW59_RS06190	COG0697	spore germination
EXW59_RS06215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW59_RS06220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW59_RS06225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW59_RS06230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW59_RS06235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW59_RS06240	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW59_RS06245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW59_RS06250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW59_RS06255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW59_RS06260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW59_RS06265	COG0138	bifunctional purine biosynthesis protein purh
EXW59_RS06270	COG0151	Belongs to the GarS family
EXW59_RS06290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW59_RS06295	COG0210	DNA helicase
EXW59_RS06300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW59_RS06305	COG4851	CamS sex pheromone cAM373 precursor
EXW59_RS06315	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS06320	COG1335	isochorismatase
EXW59_RS06330	COG2011	ABC-type metal ion transport system permease component
EXW59_RS06335	COG1464	Belongs to the NlpA lipoprotein family
EXW59_RS06350	COG0003	Pfam Anion-transporting ATPase
EXW59_RS06355	COG1846	Transcriptional regulator
EXW59_RS06360	COG4682	membrane
EXW59_RS06370	COG0154	amidase activity
EXW59_RS06375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW59_RS06380	COG1597	lipid kinase activity
EXW59_RS06390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW59_RS06400	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS06405	COG2076	Multidrug Resistance protein
EXW59_RS06410	COG2309	aminopeptidase activity
EXW59_RS06425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS06435	COG0582	viral genome integration into host DNA
EXW59_RS06600	COG0582	viral genome integration into host DNA
EXW59_RS06715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW59_RS06720	COG5002	protein histidine kinase activity
EXW59_RS06725	COG4807	Protein conserved in bacteria
EXW59_RS06750	COG1757	Na H antiporter
EXW59_RS06755	COG1473	amidohydrolase
EXW59_RS06770	COG0450	alkyl hydroperoxide reductase
EXW59_RS06780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW59_RS06790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS06795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS06800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS06805	COG0492	ferredoxin-NADP+ reductase activity
EXW59_RS06815	COG0166	Belongs to the GPI family
EXW59_RS06840	COG5002	protein histidine kinase activity
EXW59_RS06860	COG3541	Predicted nucleotidyltransferase
EXW59_RS06865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_RS06865	COG0723	plastoquinol--plastocyanin reductase activity
EXW59_RS06875	COG0765	amino acid transport
EXW59_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_RS06890	COG0840	transmembrane signaling receptor activity
EXW59_RS06895	COG0277	FAD linked oxidase domain protein
EXW59_RS06900	COG0366	Alpha amylase catalytic
EXW59_RS06905	COG1263	PTS System
EXW59_RS06905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS06905	COG2190	(PTS) system
EXW59_RS06985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW59_RS06995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW59_RS07010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_RS07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_RS07020	COG1116	anion transmembrane transporter activity
EXW59_RS07025	COG0488	(ABC) transporter
EXW59_RS07060	COG2270	Major facilitator Superfamily
EXW59_RS07090	COG2310	stress, protein
EXW59_RS07095	COG2310	stress, protein
EXW59_RS07100	COG2310	stress, protein
EXW59_RS07105	COG0861	Integral membrane protein TerC family
EXW59_RS07115	COG3853	Toxic anion resistance protein (TelA)
EXW59_RS07125	COG4840	Belongs to the UPF0435 family
EXW59_RS07140	COG1295	ribonuclease BN
EXW59_RS07145	COG2217	Heavy metal translocating P-type atpase
EXW59_RS07150	COG0697	spore germination
EXW59_RS07170	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS07185	COG3871	stress protein (general stress protein 26)
EXW59_RS07190	COG0387	Pfam Sodium calcium exchanger
EXW59_RS07200	COG0535	radical SAM domain protein
EXW59_RS07220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW59_RS07240	COG3829	transcription factor binding
EXW59_RS07250	COG0833	amino acid
EXW59_RS07255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_RS07275	COG2066	Belongs to the glutaminase family
EXW59_RS07280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS07280	COG1263	PTS System
EXW59_RS07285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_RS07300	COG1216	Glycosyl transferase, family 2
EXW59_RS07310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_RS07310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW59_RS07315	COG0463	Glycosyl transferase, family 2
EXW59_RS07330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW59_RS07335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW59_RS07350	COG1228	amidohydrolase
EXW59_RS07355	COG1090	epimerase
EXW59_RS07360	COG2137	regulation of response to DNA damage stimulus
EXW59_RS07385	COG1988	membrane-bound metal-dependent
EXW59_RS07390	COG1194	a g-specific adenine glycosylase
EXW59_RS07410	COG3557	Belongs to the UPF0374 family
EXW59_RS07415	COG1132	(ABC) transporter
EXW59_RS07420	COG4129	membrane
EXW59_RS07425	COG0070	glutamate synthase
EXW59_RS07425	COG0069	glutamate synthase activity
EXW59_RS07425	COG0067	glutamate synthase
EXW59_RS07430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW59_RS07435	COG4555	ABC transporter
EXW59_RS07455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW59_RS07460	COG0735	belongs to the Fur family
EXW59_RS07580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW59_RS07585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW59_RS07605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW59_RS07615	COG2766	serine protein kinase
EXW59_RS07620	COG2718	Belongs to the UPF0229 family
EXW59_RS07635	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW59_RS07640	COG2268	Band 7 protein
EXW59_RS07650	COG3290	protein histidine kinase activity
EXW59_RS07655	COG4565	transcriptional regulatory protein
EXW59_RS07660	COG2851	Citrate transporter
EXW59_RS07685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW59_RS07690	COG3842	ATPase activity
EXW59_RS07695	COG1175	transmembrane transport
EXW59_RS07700	COG0395	ABC-type sugar transport system, permease component
EXW59_RS07710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW59_RS07715	COG0745	RESPONSE REGULATOR receiver
EXW59_RS07720	COG5002	protein histidine kinase activity
EXW59_RS07730	COG4990	cell redox homeostasis
EXW59_RS07740	COG3290	protein histidine kinase activity
EXW59_RS07745	COG4565	transcriptional regulatory protein
EXW59_RS07750	COG3493	citrate carrier protein
EXW59_RS07755	COG0281	malic enzyme
EXW59_RS07765	COG0697	spore germination
EXW59_RS07770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS07780	COG5002	protein histidine kinase activity
EXW59_RS07785	COG0745	RESPONSE REGULATOR receiver
EXW59_RS07790	COG0456	acetyltransferase
EXW59_RS07795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW59_RS07800	COG3383	formate dehydrogenase (NAD+) activity
EXW59_RS07805	COG2427	Protein of unknown function (DUF1641)
EXW59_RS07820	COG0531	amino acid
EXW59_RS07830	COG0640	Transcriptional regulator
EXW59_RS07835	COG2217	Heavy metal translocating P-type atpase
EXW59_RS07840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW59_RS07855	COG3227	Zinc metalloprotease (Elastase)
EXW59_RS07875	COG2720	vancomycin resistance protein
EXW59_RS07880	COG1316	TRANSCRIPTIONal
EXW59_RS07885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS07890	COG0346	lactoylglutathione lyase activity
EXW59_RS07895	COG1253	flavin adenine dinucleotide binding
EXW59_RS07900	COG1027	Aspartate ammonia-lyase
EXW59_RS07905	COG1620	l-lactate permease
EXW59_RS07910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS07925	COG3104	oligopeptide transport
EXW59_RS07930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS07935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS07940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS07955	COG0156	8-amino-7-oxononanoate synthase activity
EXW59_RS07960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_RS07970	COG4548	von Willebrand factor, type A
EXW59_RS07975	COG0714	Associated with various cellular activities
EXW59_RS07995	COG0531	amino acid
EXW59_RS08000	COG2188	Transcriptional regulator
EXW59_RS08005	COG1263	PTS System
EXW59_RS08005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS08010	COG0366	Alpha amylase catalytic
EXW59_RS08025	COG0697	spore germination
EXW59_RS08030	COG4585	Histidine kinase
EXW59_RS08035	COG2197	response regulator
EXW59_RS08040	COG1404	Belongs to the peptidase S8 family
EXW59_RS08055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_RS08060	COG1115	amino acid carrier protein
EXW59_RS08065	COG1126	abc transporter atp-binding protein
EXW59_RS08070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_RS08075	COG0765	amino acid transport
EXW59_RS08080	COG0765	amino acid transport
EXW59_RS08085	COG0833	amino acid
EXW59_RS08105	COG2378	regulation of single-species biofilm formation
EXW59_RS08110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW59_RS08115	COG5002	protein histidine kinase activity
EXW59_RS08130	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_RS08155	COG0601	transmembrane transport
EXW59_RS08160	COG4608	Belongs to the ABC transporter superfamily
EXW59_RS08170	COG2271	Major facilitator Superfamily
EXW59_RS08175	COG1846	Transcriptional regulator
EXW59_RS08180	COG0477	Major facilitator Superfamily
EXW59_RS08185	COG1609	Transcriptional regulator
EXW59_RS08190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW59_RS08195	COG1869	D-ribose catabolic process
EXW59_RS08205	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW59_RS08210	COG1879	ABC-type sugar transport system periplasmic component
EXW59_RS08240	COG1063	alcohol dehydrogenase
EXW59_RS08255	COG3568	Endonuclease Exonuclease Phosphatase
EXW59_RS08285	COG0840	transmembrane signaling receptor activity
EXW59_RS08290	COG3583	domain protein
EXW59_RS08290	COG3584	3D domain protein
EXW59_RS08295	COG1476	TRANSCRIPTIONal
EXW59_RS08315	COG3104	oligopeptide transport
EXW59_RS08320	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS08335	COG1113	amino acid transport
EXW59_RS08340	COG2252	PERMEase
EXW59_RS08355	COG2153	protein acetylation
EXW59_RS08365	COG0475	glutathione-regulated potassium exporter activity
EXW59_RS08365	COG0569	domain protein
EXW59_RS08375	COG1845	cytochrome c oxidase, subunit III
EXW59_RS08380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW59_RS08390	COG0833	amino acid
EXW59_RS08395	COG4990	cell redox homeostasis
EXW59_RS08410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_RS08415	COG0697	spore germination
EXW59_RS08420	COG0531	amino acid
EXW59_RS08430	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW59_RS08435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW59_RS08445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW59_RS08450	COG0573	inorganic phosphate transmembrane transporter activity
EXW59_RS08455	COG0581	inorganic phosphate transmembrane transporter activity
EXW59_RS08465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW59_RS08585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW59_RS08600	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS08600	COG3103	Sh3 type 3 domain protein
EXW59_RS08600	COG4991	sh3 domain protein
EXW59_RS08605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW59_RS08610	COG1116	anion transmembrane transporter activity
EXW59_RS08615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_RS08620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_RS08625	COG0352	thiamine-phosphate diphosphorylase activity
EXW59_RS08630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_RS08635	COG2104	thiamine diphosphate biosynthetic process
EXW59_RS08645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_RS08650	COG0351	phosphomethylpyrimidine kinase
EXW59_RS08680	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW59_RS08685	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW59_RS08690	COG2205	protein histidine kinase activity
EXW59_RS08700	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW59_RS08705	COG1129	ABC transporter
EXW59_RS08710	COG1879	ABC-type sugar transport system periplasmic component
EXW59_RS08715	COG2252	PERMEase
EXW59_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS08780	COG0778	Nitroreductase
EXW59_RS08785	COG2719	SpoVR family
EXW59_RS08805	COG1937	Protein conserved in bacteria
EXW59_RS08810	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_RS08810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS08815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS08815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS08820	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_RS08825	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_RS08825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS08830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS08835	COG2210	Belongs to the sulfur carrier protein TusA family
EXW59_RS08840	COG0730	response to heat
EXW59_RS08850	COG1316	TRANSCRIPTIONal
EXW59_RS08855	COG0604	alcohol dehydrogenase
EXW59_RS08860	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW59_RS08870	COG2814	Major facilitator Superfamily
EXW59_RS08880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_RS08880	COG3711	transcriptional antiterminator
EXW59_RS08885	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_RS08890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_RS08910	COG3584	3D domain protein
EXW59_RS08910	COG1388	LysM domain
EXW59_RS08915	COG0577	efflux transmembrane transporter activity
EXW59_RS08920	COG1136	(ABC) transporter
EXW59_RS08930	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW59_RS08945	COG0577	efflux transmembrane transporter activity
EXW59_RS08950	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS08955	COG3546	catalase activity
EXW59_RS08980	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS09010	COG0531	amino acid
EXW59_RS09015	COG0475	glutathione-regulated potassium exporter activity
EXW59_RS09025	COG1737	Transcriptional regulator
EXW59_RS09030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW59_RS09035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS09035	COG1263	PTS System
EXW59_RS09045	COG2259	Doxx family
EXW59_RS09065	COG0697	spore germination
EXW59_RS09070	COG1522	sequence-specific DNA binding
EXW59_RS09095	COG2076	Multidrug Resistance protein
EXW59_RS09100	COG1309	transcriptional regulator
EXW59_RS09105	COG2814	Major facilitator Superfamily
EXW59_RS09110	COG1733	regulation of RNA biosynthetic process
EXW59_RS09130	COG4533	DNA binding
EXW59_RS09135	COG2211	Major facilitator Superfamily
EXW59_RS09145	COG0693	protein deglycase activity
EXW59_RS09155	COG0531	amino acid
EXW59_RS09160	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS09165	COG1132	(ABC) transporter
EXW59_RS09170	COG1132	(ABC) transporter
EXW59_RS09175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_RS09180	COG0765	amino acid transport
EXW59_RS09185	COG1126	abc transporter atp-binding protein
EXW59_RS09200	COG0189	ligase activity
EXW59_RS09210	COG4399	Belongs to the UPF0754 family
EXW59_RS09215	COG3679	Belongs to the UPF0342 family
EXW59_RS09230	COG0028	Belongs to the TPP enzyme family
EXW59_RS09235	COG3527	Alpha-acetolactate decarboxylase
EXW59_RS09240	COG0463	Glycosyl transferase, family 2
EXW59_RS09245	COG1216	Glycosyl transferase, family 2
EXW59_RS09250	COG2094	Belongs to the DNA glycosylase MPG family
EXW59_RS09255	COG0561	phosphatase activity
EXW59_RS09265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW59_RS09270	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS09275	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS09285	COG0789	Transcriptional regulator
EXW59_RS09285	COG4978	Transcriptional regulator
EXW59_RS09295	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_RS09310	COG0653	protein targeting
EXW59_RS09315	COG2244	polysaccharide biosynthetic process
EXW59_RS09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS09345	COG1696	Membrane protein involved in D-alanine export
EXW59_RS09360	COG1024	Enoyl-CoA hydratase
EXW59_RS09375	COG1363	Peptidase, m42
EXW59_RS09390	COG2318	DinB family
EXW59_RS09410	COG0579	oxidoreductase
EXW59_RS09445	COG0601	transmembrane transport
EXW59_RS09450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_RS09455	COG0444	Belongs to the ABC transporter superfamily
EXW59_RS09460	COG4608	Belongs to the ABC transporter superfamily
EXW59_RS09485	COG0582	viral genome integration into host DNA
EXW59_RS09600	COG0477	Major facilitator Superfamily
EXW59_RS09605	COG3290	protein histidine kinase activity
EXW59_RS09610	COG4565	transcriptional regulatory protein
EXW59_RS09615	COG3181	Tripartite tricarboxylate transporter family receptor
EXW59_RS09620	COG0494	nUDIX hydrolase
EXW59_RS09670	COG0305	Participates in initiation and elongation during chromosome replication
EXW59_RS09695	COG1309	transcriptional regulator
EXW59_RS09700	COG1902	pentaerythritol trinitrate reductase activity
EXW59_RS09705	COG1073	alpha beta
EXW59_RS09725	COG1842	Phage shock protein A
EXW59_RS09740	COG0477	Major facilitator Superfamily
EXW59_RS09815	COG2732	(Barnase) inhibitor
EXW59_RS09820	COG2814	Major facilitator Superfamily
EXW59_RS09825	COG0640	Transcriptional regulator
EXW59_RS09865	COG2376	Dihydroxyacetone kinase
EXW59_RS09875	COG2376	Dihydroxyacetone kinase
EXW59_RS09885	COG1959	2 iron, 2 sulfur cluster binding
EXW59_RS09905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_RS09920	COG2720	vancomycin resistance protein
EXW59_RS09960	COG3237	CsbD-like
EXW59_RS09980	COG2172	sigma factor antagonist activity
EXW59_RS09985	COG1191	sigma factor activity
EXW59_RS09995	COG2208	phosphoserine phosphatase activity
EXW59_RS10000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW59_RS10005	COG0784	Response regulator, receiver
EXW59_RS10005	COG5002	protein histidine kinase activity
EXW59_RS10005	COG2205	protein histidine kinase activity
EXW59_RS10040	COG2807	transmembrane transport
EXW59_RS10075	COG0420	3'-5' exonuclease activity
EXW59_RS10080	COG4717	serine-type aminopeptidase activity
EXW59_RS10085	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW59_RS10090	COG0346	lactoylglutathione lyase activity
EXW59_RS10095	COG0346	lactoylglutathione lyase activity
EXW59_RS10100	COG0457	Tetratricopeptide repeat
EXW59_RS10110	COG2267	carboxylic ester hydrolase activity
EXW59_RS10145	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW59_RS10150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW59_RS10155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW59_RS10160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW59_RS10175	COG1595	DNA-templated transcription, initiation
EXW59_RS10195	COG3973	AAA domain
EXW59_RS10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_RS10215	COG1846	Transcriptional regulator
EXW59_RS10225	COG0537	adenosine 5'-monophosphoramidase activity
EXW59_RS10230	COG1131	(ABC) transporter
EXW59_RS10235	COG4473	ABC transporter
EXW59_RS10245	COG0247	lactate metabolic process
EXW59_RS10250	COG1139	Iron-sulfur cluster binding protein
EXW59_RS10255	COG1556	Lactate utilization protein
EXW59_RS10275	COG3402	PFAM membrane-flanked domain
EXW59_RS10280	COG3428	Bacterial PH domain
EXW59_RS10320	COG3402	PFAM membrane-flanked domain
EXW59_RS10325	COG3428	Bacterial PH domain
EXW59_RS10330	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_RS10335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS10340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW59_RS10345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW59_RS10350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW59_RS10380	COG1309	transcriptional regulator
EXW59_RS10385	COG1511	domain protein
EXW59_RS10420	COG2378	regulation of single-species biofilm formation
EXW59_RS10425	COG1609	Transcriptional regulator
EXW59_RS10435	COG1234	tRNA 3'-trailer cleavage
EXW59_RS10440	COG0095	Lipoate-protein ligase
EXW59_RS10450	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS10465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW59_RS10475	COG4208	sulfate ABC transporter
EXW59_RS10485	COG3209	COG3209 Rhs family protein
EXW59_RS10510	COG1408	metallophosphoesterase
EXW59_RS10515	COG1078	dGTPase activity
EXW59_RS10530	COG1595	DNA-templated transcription, initiation
EXW59_RS10535	COG3708	Transcriptional regulator
EXW59_RS10535	COG2207	Transcriptional regulator
EXW59_RS10540	COG2205	protein histidine kinase activity
EXW59_RS10545	COG0745	RESPONSE REGULATOR receiver
EXW59_RS10565	COG0501	Belongs to the peptidase M48B family
EXW59_RS10570	COG0697	spore germination
EXW59_RS10590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW59_RS10595	COG2224	Isocitrate lyase
EXW59_RS10605	COG1278	Cold shock
EXW59_RS10615	COG4903	ComK protein
EXW59_RS10620	COG0398	Pfam SNARE associated Golgi protein
EXW59_RS10630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW59_RS10635	COG1074	ATP-dependent DNA helicase activity
EXW59_RS10685	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW59_RS10710	COG0367	asparagine synthase
EXW59_RS10720	COG0753	catalase activity
EXW59_RS10725	COG0004	ammonium transporteR
EXW59_RS10735	COG1666	GTP binding
EXW59_RS10740	COG2996	Protein conserved in bacteria
EXW59_RS10745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_RS10755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS10770	COG0561	phosphatase activity
EXW59_RS10790	COG2267	carboxylic ester hydrolase activity
EXW59_RS10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_RS10810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW59_RS10815	COG5504	Zn-dependent protease
EXW59_RS10825	COG0180	Tryptophanyl-tRNA synthetase
EXW59_RS10835	COG4166	transmembrane transport
EXW59_RS10840	COG0601	transmembrane transport
EXW59_RS10845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_RS10850	COG0444	Belongs to the ABC transporter superfamily
EXW59_RS10855	COG4608	Belongs to the ABC transporter superfamily
EXW59_RS10860	COG0534	Mate efflux family protein
EXW59_RS10865	COG4166	transmembrane transport
EXW59_RS10880	COG0861	Integral membrane protein TerC family
EXW59_RS10885	COG4862	establishment of competence for transformation
EXW59_RS10890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_RS10900	COG1164	Oligoendopeptidase f
EXW59_RS10915	COG2346	COG2346, Truncated hemoglobins
EXW59_RS10920	COG4116	CYTH
EXW59_RS10930	COG2357	RelA SpoT domain protein
EXW59_RS10940	COG0564	pseudouridine synthase activity
EXW59_RS10950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW59_RS10955	COG0772	Belongs to the SEDS family
EXW59_RS10960	COG1216	Glycosyl transferase, family 2
EXW59_RS10980	COG0457	Tetratricopeptide repeat
EXW59_RS10980	COG0463	Glycosyl transferase, family 2
EXW59_RS11000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW59_RS11015	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW59_RS11060	COG2153	protein acetylation
EXW59_RS11065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW59_RS11070	COG2382	esterase
EXW59_RS11095	COG5492	domain, Protein
EXW59_RS11100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_RS11110	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW59_RS11110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW59_RS11115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW59_RS11120	COG0134	indole-3-glycerol-phosphate synthase activity
EXW59_RS11125	COG0135	phosphoribosylanthranilate isomerase activity
EXW59_RS11130	COG0133	tryptophan synthase activity
EXW59_RS11135	COG0159	tryptophan synthase activity
EXW59_RS11145	COG1620	l-lactate permease
EXW59_RS11175	COG1396	sequence-specific DNA binding
EXW59_RS11205	COG1846	Transcriptional regulator
EXW59_RS11210	COG1484	DNA-dependent DNA replication
EXW59_RS11265	COG0582	viral genome integration into host DNA
EXW59_RS11290	COG5484	DNA packaging
EXW59_RS11375	COG4824	toxin secretion phage lysis holin
EXW59_RS11455	COG2226	methyltransferase
EXW59_RS11475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_RS11480	COG0567	Dehydrogenase, E1 component
EXW59_RS11485	COG1476	TRANSCRIPTIONal
EXW59_RS11515	COG4152	abc transporter atp-binding protein
EXW59_RS11520	COG1668	transmembrane transport
EXW59_RS11550	COG1686	Belongs to the peptidase S11 family
EXW59_RS11555	COG0681	Belongs to the peptidase S26 family
EXW59_RS11590	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS11600	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW59_RS11605	COG1177	transmembrane transport
EXW59_RS11610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW59_RS11620	COG2409	Drug exporters of the RND superfamily
EXW59_RS11630	COG0564	pseudouridine synthase activity
EXW59_RS11640	COG2340	Cysteine-rich secretory protein family
EXW59_RS11645	COG0247	lactate metabolic process
EXW59_RS11650	COG0277	FAD linked oxidase domain protein
EXW59_RS11665	COG0745	RESPONSE REGULATOR receiver
EXW59_RS11670	COG5002	protein histidine kinase activity
EXW59_RS11675	COG2186	Transcriptional regulator
EXW59_RS11680	COG0247	lactate metabolic process
EXW59_RS11685	COG1139	Iron-sulfur cluster binding protein
EXW59_RS11690	COG1556	Lactate utilization protein
EXW59_RS11695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW59_RS11705	COG2116	formate transmembrane transporter activity
EXW59_RS11710	COG0861	Integral membrane protein TerC family
EXW59_RS11715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_RS11725	COG2030	dehydratase
EXW59_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS11750	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW59_RS11760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_RS11775	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW59_RS11780	COG3842	ATPase activity
EXW59_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW59_RS11795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW59_RS11805	COG1349	DNA-binding transcription factor activity
EXW59_RS11815	COG0235	Class ii aldolase
EXW59_RS11825	COG2861	carbohydrate metabolic process
EXW59_RS11835	COG3852	Histidine kinase
EXW59_RS11840	COG1846	Transcriptional regulator
EXW59_RS11850	COG2318	DinB family
EXW59_RS11855	COG5002	protein histidine kinase activity
EXW59_RS11860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW59_RS11865	COG0720	synthase
EXW59_RS11875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW59_RS11880	COG4873	Protein conserved in bacteria
EXW59_RS11895	COG0456	acetyltransferase
EXW59_RS11910	COG1780	Probably involved in ribonucleotide reductase function
EXW59_RS11925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW59_RS11930	COG0531	amino acid
EXW59_RS11935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW59_RS11950	COG2204	response regulator
EXW59_RS11955	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS11965	COG1725	Transcriptional regulator
EXW59_RS11970	COG1131	(ABC) transporter
EXW59_RS11980	COG1131	(ABC) transporter
EXW59_RS11985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_RS11990	COG1266	CAAX protease self-immunity
EXW59_RS12000	COG1522	sequence-specific DNA binding
EXW59_RS12010	COG1335	isochorismatase
EXW59_RS12020	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_RS12025	COG2070	2-Nitropropane dioxygenase
EXW59_RS12030	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW59_RS12035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_RS12040	COG1696	Membrane protein involved in D-alanine export
EXW59_RS12045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW59_RS12065	COG0716	FMN binding
EXW59_RS12100	COG0534	Mate efflux family protein
EXW59_RS12120	COG1846	Transcriptional regulator
EXW59_RS12130	COG1301	dicarboxylic acid transport
EXW59_RS12135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_RS12145	COG3874	Sporulation protein YtfJ
EXW59_RS12165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_RS12170	COG0028	Belongs to the TPP enzyme family
EXW59_RS12175	COG0440	acetolactate synthase activity
EXW59_RS12185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW59_RS12195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW59_RS12205	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW59_RS12210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW59_RS12220	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW59_RS12225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW59_RS12230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW59_RS12235	COG0107	imidazoleglycerol-phosphate synthase activity
EXW59_RS12245	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW59_RS12250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW59_RS12265	COG1183	phosphatidylcholine synthase activity
EXW59_RS12270	COG1368	sulfuric ester hydrolase activity
EXW59_RS12280	COG0019	diaminopimelate decarboxylase activity
EXW59_RS12290	COG0175	sulfate reduction
EXW59_RS12295	COG2046	Belongs to the sulfate adenylyltransferase family
EXW59_RS12300	COG0529	Catalyzes the synthesis of activated sulfate
EXW59_RS12305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW59_RS12325	COG1648	precorrin-2 dehydrogenase activity
EXW59_RS12330	COG0733	neurotransmitter:sodium symporter activity
EXW59_RS12355	COG1757	Na H antiporter
EXW59_RS12375	COG4758	membrane
EXW59_RS12380	COG4585	Histidine kinase
EXW59_RS12385	COG2197	response regulator
EXW59_RS12395	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS12405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW59_RS12445	COG0730	response to heat
EXW59_RS12450	COG0306	phosphate transporter
EXW59_RS12455	COG1392	Phosphate transport regulator
EXW59_RS12460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS12475	COG3852	Histidine kinase
EXW59_RS12480	COG1801	Protein of unknown function DUF72
EXW59_RS12490	COG0582	viral genome integration into host DNA
EXW59_RS12495	COG5002	protein histidine kinase activity
EXW59_RS12510	COG0392	lysyltransferase activity
EXW59_RS12510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW59_RS12525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_RS12530	COG1686	Belongs to the peptidase S11 family
EXW59_RS12535	COG2715	membrane protein required for spore maturation
EXW59_RS12540	COG0700	Nucleoside recognition
EXW59_RS12545	COG1187	pseudouridine synthase activity
EXW59_RS12555	COG1333	cytochrome c biogenesis protein
EXW59_RS12560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW59_RS12565	COG0745	RESPONSE REGULATOR receiver
EXW59_RS12570	COG5002	protein histidine kinase activity
EXW59_RS12575	COG2096	Adenosyltransferase
EXW59_RS12580	COG4942	peptidase
EXW59_RS12590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW59_RS12595	COG1141	Ferredoxin
EXW59_RS12600	COG4955	Helix-turn-helix domain
EXW59_RS12605	COG0514	ATP-dependent DNA helicase (RecQ)
EXW59_RS12610	COG1266	CAAX protease self-immunity
EXW59_RS12620	COG1408	metallophosphoesterase
EXW59_RS12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW59_RS12655	COG0492	ferredoxin-NADP+ reductase activity
EXW59_RS12660	COG0252	asparaginase activity
EXW59_RS12670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW59_RS12680	COG1304	FMN binding
EXW59_RS12710	COG1160	GTP binding
EXW59_RS12715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW59_RS12735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_RS12745	COG0302	gtp cyclohydrolase
EXW59_RS12750	COG0142	geranyltranstransferase activity
EXW59_RS12755	COG2226	methyltransferase
EXW59_RS12760	COG0142	geranyltranstransferase activity
EXW59_RS12775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW59_RS12785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW59_RS12790	COG0457	Tetratricopeptide repeat
EXW59_RS12795	COG5582	Belongs to the UPF0302 family
EXW59_RS12810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW59_RS12825	COG4347	Protein of unknown function (DUF1405)
EXW59_RS12840	COG2738	Putative neutral zinc metallopeptidase
EXW59_RS12850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS12855	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW59_RS12860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW59_RS12865	COG1803	Methylglyoxal synthase
EXW59_RS12870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_RS12875	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS12880	COG0617	tRNA 3'-terminal CCA addition
EXW59_RS12890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW59_RS12895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW59_RS12905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW59_RS12905	COG1199	ATP-dependent helicase activity
EXW59_RS12925	COG3935	DnaD domain protein
EXW59_RS12930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW59_RS12940	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_RS12940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS12945	COG3331	DNA recombination
EXW59_RS12980	COG4474	Belongs to the UPF0398 family
EXW59_RS12985	COG3599	regulation of cell shape
EXW59_RS12995	COG0116	Belongs to the methyltransferase superfamily
EXW59_RS13005	COG1199	ATP-dependent helicase activity
EXW59_RS13010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW59_RS13020	COG0024	Methionine aminopeptidase
EXW59_RS13025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_RS13030	COG2233	PERMEase
EXW59_RS13035	COG2311	Membrane
EXW59_RS13045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_RS13055	COG0456	acetyltransferase
EXW59_RS13065	COG2897	thiosulfate sulfurtransferase activity
EXW59_RS13105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_RS13120	COG0454	-acetyltransferase
EXW59_RS13140	COG0328	RNA-DNA hybrid ribonuclease activity
EXW59_RS13175	COG3403	YqcI/YcgG family
EXW59_RS13180	COG1280	lysine exporter protein (LysE YggA)
EXW59_RS13195	COG3162	membrane
EXW59_RS13200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_RS13205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_RS13215	COG0475	glutathione-regulated potassium exporter activity
EXW59_RS13220	COG0789	Transcriptional regulator
EXW59_RS13220	COG4978	Transcriptional regulator
EXW59_RS13230	COG2323	membrane
EXW59_RS13235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW59_RS13265	COG2814	Major facilitator Superfamily
EXW59_RS13285	COG1923	regulation of RNA biosynthetic process
EXW59_RS13295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW59_RS13300	COG1360	Flagellar Motor Protein
EXW59_RS13305	COG2201	protein-glutamate methylesterase activity
EXW59_RS13310	COG2198	Histidine kinase
EXW59_RS13310	COG0643	Histidine kinase
EXW59_RS13315	COG1776	CheC inhibitor of MCP methylation
EXW59_RS13315	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_RS13330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW59_RS13350	COG1256	bacterial-type flagellum assembly
EXW59_RS13355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW59_RS13375	COG1815	bacterial-type flagellum-dependent cell motility
EXW59_RS13380	COG1558	bacterial-type flagellum-dependent cell motility
EXW59_RS13390	COG1766	The M ring may be actively involved in energy transduction
EXW59_RS13395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_RS13405	COG1157	protein secretion by the type III secretion system
EXW59_RS13425	COG1749	Flagellar hook protein flgE
EXW59_RS13440	COG0835	chemotaxis
EXW59_RS13440	COG0784	Response regulator, receiver
EXW59_RS13460	COG0861	Integral membrane protein TerC family
EXW59_RS13470	COG3383	formate dehydrogenase (NAD+) activity
EXW59_RS13475	COG2427	Protein of unknown function (DUF1641)
EXW59_RS13480	COG5609	conserved protein (DUF2294)
EXW59_RS13485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW59_RS13495	COG2116	formate transmembrane transporter activity
EXW59_RS13500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_RS13505	COG0303	'Molybdopterin
EXW59_RS13510	COG0314	molybdopterin synthase activity
EXW59_RS13515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW59_RS13525	COG0489	protein tyrosine kinase activity
EXW59_RS13530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW59_RS13535	COG0741	lytic transglycosylase activity
EXW59_RS13545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_RS13550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_RS13550	COG1776	CheC inhibitor of MCP methylation
EXW59_RS13560	COG1338	Plays a role in the flagellum-specific transport system
EXW59_RS13565	COG1987	bacterial-type flagellum assembly
EXW59_RS13575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW59_RS13580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW59_RS13585	COG1419	protein localization to endoplasmic reticulum
EXW59_RS13590	COG4786	Flagellar basal body rod
EXW59_RS13605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_RS13635	COG0412	Dienelactone hydrolase
EXW59_RS13640	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_RS13655	COG2814	Major facilitator Superfamily
EXW59_RS13665	COG0583	DNA-binding transcription factor activity
EXW59_RS13670	COG3842	ATPase activity
EXW59_RS13750	COG0367	asparagine synthase
EXW59_RS13780	COG1802	Transcriptional regulator
EXW59_RS13785	COG0697	spore germination
EXW59_RS13790	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS13790	COG1216	Glycosyl transferase, family 2
EXW59_RS13795	COG1757	Na H antiporter
EXW59_RS13805	COG0277	FAD linked oxidase domain protein
EXW59_RS13825	COG0534	Mate efflux family protein
EXW59_RS13830	COG3340	Belongs to the peptidase S51 family
EXW59_RS13850	COG0785	Cytochrome C biogenesis protein
EXW59_RS13855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS13870	COG3048	D-serine ammonia-lyase activity
EXW59_RS13875	COG2733	membrane
EXW59_RS13910	COG1131	(ABC) transporter
EXW59_RS13930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_RS13935	COG0528	UMP kinase activity
EXW59_RS13945	COG1027	Aspartate ammonia-lyase
EXW59_RS13950	COG0281	malic enzyme
EXW59_RS13955	COG4191	Histidine kinase
EXW59_RS13960	COG0784	Response regulator, receiver
EXW59_RS13965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_RS13975	COG2502	aspartate--ammonia ligase
EXW59_RS13980	COG3620	sequence-specific DNA binding
EXW59_RS14010	COG1051	belongs to the nudix hydrolase family
EXW59_RS14015	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS14025	COG2814	Major facilitator Superfamily
EXW59_RS14055	COG0477	Major facilitator Superfamily
EXW59_RS14070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW59_RS14075	COG2223	nitrite transmembrane transporter activity
EXW59_RS14080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_RS14095	COG2244	polysaccharide biosynthetic process
EXW59_RS14100	COG0733	neurotransmitter:sodium symporter activity
EXW59_RS14110	COG5566	PFAM Mor transcription activator
EXW59_RS14115	COG2323	membrane
EXW59_RS14135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_RS14140	COG2132	Multicopper oxidase
EXW59_RS14150	COG5002	protein histidine kinase activity
EXW59_RS14155	COG0745	RESPONSE REGULATOR receiver
EXW59_RS14165	COG0129	dihydroxy-acid dehydratase activity
EXW59_RS14170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW59_RS14195	COG2814	Major facilitator Superfamily
EXW59_RS14200	COG3384	dioxygenase
EXW59_RS14245	COG4166	transmembrane transport
EXW59_RS14270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS14290	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW59_RS14295	COG1054	Belongs to the UPF0176 family
EXW59_RS14305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW59_RS14310	COG0531	amino acid
EXW59_RS14335	COG2390	Transcriptional regulator
EXW59_RS14345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW59_RS14350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS14355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW59_RS14370	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW59_RS14390	COG0583	DNA-binding transcription factor activity
EXW59_RS14410	COG0006	proline dipeptidase activity
EXW59_RS14415	COG2132	Multicopper oxidase
EXW59_RS14425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW59_RS14435	COG0583	DNA-binding transcription factor activity
EXW59_RS14455	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS14465	COG1834	amidinotransferase
EXW59_RS14475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_RS14490	COG1276	copper resistance
EXW59_RS14490	COG2372	response to copper ion
EXW59_RS14495	COG4549	nuclear export factor GLE1
EXW59_RS14505	COG0697	spore germination
EXW59_RS14510	COG0583	DNA-binding transcription factor activity
EXW59_RS14515	COG1959	2 iron, 2 sulfur cluster binding
EXW59_RS14520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW59_RS14525	COG0778	Nitroreductase
EXW59_RS14540	COG0628	permease
EXW59_RS14555	COG1231	oxidoreductase activity
EXW59_RS14560	COG0523	cobalamin synthesis protein
EXW59_RS14570	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS14575	COG2030	dehydratase
EXW59_RS14580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_RS14595	COG0411	ABC transporter
EXW59_RS14615	COG0583	DNA-binding transcription factor activity
EXW59_RS14625	COG1942	4-Oxalocrotonate Tautomerase
EXW59_RS14640	COG0346	lactoylglutathione lyase activity
EXW59_RS14650	COG1271	oxidase subunit
EXW59_RS14655	COG1294	oxidase, subunit
EXW59_RS14660	COG4988	ABC transporter
EXW59_RS14665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW59_RS14695	COG1686	Belongs to the peptidase S11 family
EXW59_RS14710	COG0791	NLP P60 protein
EXW59_RS14710	COG1388	LysM domain
EXW59_RS14720	COG1132	(ABC) transporter
EXW59_RS14725	COG0745	RESPONSE REGULATOR receiver
EXW59_RS14730	COG5002	protein histidine kinase activity
EXW59_RS14735	COG0300	oxidoreductase activity
EXW59_RS14740	COG4122	O-methyltransferase activity
EXW59_RS14755	COG5658	integral membrane protein
EXW59_RS14770	COG0460	homoserine dehydrogenase
EXW59_RS14780	COG0083	homoserine kinase activity
EXW59_RS14795	COG1316	TRANSCRIPTIONal
EXW59_RS14805	COG0745	RESPONSE REGULATOR receiver
EXW59_RS14810	COG5002	protein histidine kinase activity
EXW59_RS14825	COG1285	pathogenesis
EXW59_RS14830	COG1247	-acetyltransferase
EXW59_RS14850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_RS14860	COG1082	Xylose isomerase domain protein TIM barrel
EXW59_RS14870	COG2814	Major facilitator Superfamily
EXW59_RS14875	COG1279	arginine transmembrane transporter activity
EXW59_RS14880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS14890	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW59_RS14920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW59_RS14925	COG0577	efflux transmembrane transporter activity
EXW59_RS14930	COG2002	toxin-antitoxin pair type II binding
EXW59_RS14935	COG1404	Belongs to the peptidase S8 family
EXW59_RS14940	COG0640	Transcriptional regulator
EXW59_RS14945	COG0667	Aldo Keto reductase
EXW59_RS14990	COG3949	Membrane
EXW59_RS14995	COG0783	Belongs to the Dps family
EXW59_RS15010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_RS15020	COG1231	oxidoreductase activity
EXW59_RS15025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS15035	COG2267	carboxylic ester hydrolase activity
EXW59_RS15040	COG2378	regulation of single-species biofilm formation
EXW59_RS15060	COG4989	oxidoreductase activity
EXW59_RS15065	COG0523	cobalamin synthesis protein
EXW59_RS15070	COG0456	acetyltransferase
EXW59_RS15075	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW59_RS15090	COG1902	pentaerythritol trinitrate reductase activity
EXW59_RS15095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW59_RS15105	COG4166	transmembrane transport
EXW59_RS15110	COG0346	lactoylglutathione lyase activity
EXW59_RS15120	COG0406	alpha-ribazole phosphatase activity
EXW59_RS15130	COG5337	Spore coat protein CotH
EXW59_RS15135	COG1051	belongs to the nudix hydrolase family
EXW59_RS15140	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS15145	COG2244	polysaccharide biosynthetic process
EXW59_RS15155	COG0701	Predicted permease
EXW59_RS15160	COG3689	TIGRFAM TIGR03943 family protein
EXW59_RS15165	COG1607	acyl-coa hydrolase
EXW59_RS15175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_RS15190	COG0702	epimerase
EXW59_RS15195	COG2839	Protein conserved in bacteria
EXW59_RS15200	COG1253	flavin adenine dinucleotide binding
EXW59_RS15225	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS15230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_RS15245	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS15255	COG1876	peptidase activity
EXW59_RS15260	COG0494	nUDIX hydrolase
EXW59_RS15270	COG2211	Major facilitator Superfamily
EXW59_RS15285	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS15295	COG0561	phosphatase activity
EXW59_RS15300	COG1846	Transcriptional regulator
EXW59_RS15305	COG2814	Major facilitator Superfamily
EXW59_RS15315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_RS15320	COG4106	trans-aconitate 2-methyltransferase activity
EXW59_RS15335	COG1819	glycosyl
EXW59_RS15340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS15345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS15370	COG0456	acetyltransferase
EXW59_RS15405	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_RS15470	COG3874	Sporulation protein YtfJ
EXW59_RS15495	COG2226	methyltransferase
EXW59_RS15515	COG1082	Xylose isomerase domain protein TIM barrel
EXW59_RS15520	COG0346	lactoylglutathione lyase activity
EXW59_RS15530	COG0604	alcohol dehydrogenase
EXW59_RS15535	COG1595	DNA-templated transcription, initiation
EXW59_RS15560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW59_RS15560	COG0426	domain, Protein
EXW59_RS15570	COG0386	Belongs to the glutathione peroxidase family
EXW59_RS15575	COG1305	Transglutaminase-like
EXW59_RS15580	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW59_RS15585	COG0714	Associated with various cellular activities
EXW59_RS15590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW59_RS15595	COG1140	nitrate reductase beta subunit
EXW59_RS15600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW59_RS15605	COG2181	nitrate reductase activity
EXW59_RS15610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW59_RS15615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW59_RS15620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_RS15625	COG0303	'Molybdopterin
EXW59_RS15630	COG0314	molybdopterin synthase activity
EXW59_RS15640	COG2223	nitrite transmembrane transporter activity
EXW59_RS15660	COG1648	precorrin-2 dehydrogenase activity
EXW59_RS15670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW59_RS15670	COG1587	Uroporphyrinogen-III synthase
EXW59_RS15675	COG2146	nitrite reductase [NAD(P)H] activity
EXW59_RS15680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW59_RS15685	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW59_RS15715	COG2359	stage V sporulation protein S
EXW59_RS15725	COG1418	mRNA catabolic process
EXW59_RS15730	COG0488	(ABC) transporter
EXW59_RS15760	COG1413	lyase activity
EXW59_RS15775	COG2136	Putative SAM-dependent methyltransferase
EXW59_RS15775	COG2521	methyltransferase
EXW59_RS15780	COG0018	arginyl-trna synthetase
EXW59_RS15795	COG2226	methyltransferase
EXW59_RS15830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW59_RS15835	COG0017	Asparaginyl-tRNA synthetase
EXW59_RS15840	COG0733	neurotransmitter:sodium symporter activity
EXW59_RS15865	COG2610	gluconate transmembrane transporter activity
EXW59_RS15875	COG1794	racemase activity, acting on amino acids and derivatives
EXW59_RS15885	COG0456	acetyltransferase
EXW59_RS15890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW59_RS15895	COG1131	(ABC) transporter
EXW59_RS15900	COG4473	ABC transporter
EXW59_RS15910	COG0546	phosphoglycolate phosphatase activity
EXW59_RS15940	COG0768	penicillin binding
EXW59_RS15955	COG1272	protein, Hemolysin III
EXW59_RS15960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW59_RS15965	COG0805	protein transport
EXW59_RS15975	COG1307	EDD domain protein, DegV family
EXW59_RS15980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW59_RS15985	COG1999	signal sequence binding
EXW59_RS15990	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW59_RS15995	COG0367	asparagine synthase
EXW59_RS16010	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS16015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS16020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_RS16035	COG1335	isochorismatase
EXW59_RS16040	COG1051	belongs to the nudix hydrolase family
EXW59_RS16045	COG0668	transmembrane transport
EXW59_RS16050	COG2203	Gaf domain
EXW59_RS16050	COG4585	Histidine kinase
EXW59_RS16055	COG2197	response regulator
EXW59_RS16060	COG1737	Transcriptional regulator
EXW59_RS16065	COG1064	alcohol dehydrogenase
EXW59_RS16085	COG1070	Carbohydrate kinase
EXW59_RS16095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW59_RS16115	COG0517	IMP dehydrogenase activity
EXW59_RS16115	COG1125	glycine betaine transport
EXW59_RS16120	COG1174	glycine betaine transport
EXW59_RS16155	COG1253	flavin adenine dinucleotide binding
EXW59_RS16160	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS16165	COG5506	Protein of unknown function (DUF1694)
EXW59_RS16180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_RS16185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW59_RS16190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW59_RS16195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_RS16200	COG0456	acetyltransferase
EXW59_RS16205	COG3829	transcription factor binding
EXW59_RS16210	COG1509	lysine 2,3-aminomutase activity
EXW59_RS16220	COG4479	Belongs to the UPF0346 family
EXW59_RS16245	COG3064	Membrane
EXW59_RS16245	COG4991	sh3 domain protein
EXW59_RS16245	COG0515	serine threonine protein kinase
EXW59_RS16255	COG0671	phosphoesterase, PA-phosphatase related
EXW59_RS16260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_RS16265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS16320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_RS16345	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS16365	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_RS16365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS16375	COG2814	Major facilitator Superfamily
EXW59_RS16385	COG0372	Belongs to the citrate synthase family
EXW59_RS16390	COG2079	MmgE PrpD family protein
EXW59_RS16395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW59_RS16400	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS16405	COG2084	Dehydrogenase
EXW59_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS16415	COG1280	lysine exporter protein (LysE YggA)
EXW59_RS16420	COG1024	Enoyl-CoA hydratase
EXW59_RS16435	COG0420	3'-5' exonuclease activity
EXW59_RS16460	COG2223	nitrite transmembrane transporter activity
EXW59_RS16465	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS16470	COG1169	isochorismate synthase
EXW59_RS16475	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW59_RS16480	COG1535	isochorismatase
EXW59_RS16480	COG3433	isochorismatase activity
EXW59_RS16485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW59_RS16490	COG3251	PFAM MbtH domain protein
EXW59_RS16495	COG2814	Major facilitator Superfamily
EXW59_RS16510	COG0776	regulation of translation
EXW59_RS16520	COG2318	DinB family
EXW59_RS16525	COG1115	amino acid carrier protein
EXW59_RS16540	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_RS16550	COG1187	pseudouridine synthase activity
EXW59_RS16555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW59_RS16560	COG3655	Transcriptional regulator
EXW59_RS16570	COG1136	(ABC) transporter
EXW59_RS16580	COG0596	Alpha beta hydrolase
EXW59_RS16595	COG0028	Belongs to the TPP enzyme family
EXW59_RS16620	COG1253	flavin adenine dinucleotide binding
EXW59_RS16660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW59_RS16680	COG1846	Transcriptional regulator
EXW59_RS16690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS16695	COG1309	transcriptional regulator
EXW59_RS16725	COG1247	-acetyltransferase
EXW59_RS16750	COG0596	Alpha beta hydrolase
EXW59_RS16755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW59_RS16765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS16795	COG0583	DNA-binding transcription factor activity
EXW59_RS16800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW59_RS16835	COG3344	reverse transcriptase
EXW59_RS16850	COG0583	DNA-binding transcription factor activity
EXW59_RS16855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW59_RS16860	COG2258	MOSC domain
EXW59_RS16875	COG1132	(ABC) transporter
EXW59_RS16880	COG1132	(ABC) transporter
EXW59_RS16900	COG1396	sequence-specific DNA binding
EXW59_RS16940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW59_RS16945	COG1595	DNA-templated transcription, initiation
EXW59_RS16970	COG1649	PFAM Uncharacterised BCR, COG1649
EXW59_RS16990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW59_RS16995	COG2971	BadF BadG BcrA BcrD
EXW59_RS17045	COG1309	transcriptional regulator
EXW59_RS17060	COG0577	efflux transmembrane transporter activity
EXW59_RS17060	COG1136	(ABC) transporter
EXW59_RS17065	COG0500	methyltransferase
EXW59_RS17065	COG3615	Tellurite resistance protein tehB
EXW59_RS17075	COG0693	protein deglycase activity
EXW59_RS17085	COG0588	phosphoglycerate mutase activity
EXW59_RS17110	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_RS17125	COG0110	maltose O-acetyltransferase activity
EXW59_RS17130	COG1136	(ABC) transporter
EXW59_RS17160	COG1686	Belongs to the peptidase S11 family
EXW59_RS17185	COG0768	penicillin binding
EXW59_RS17190	COG0745	RESPONSE REGULATOR receiver
EXW59_RS17195	COG2205	protein histidine kinase activity
EXW59_RS17200	COG1136	(ABC) transporter
EXW59_RS17205	COG0577	efflux transmembrane transporter activity
EXW59_RS17215	COG1595	DNA-templated transcription, initiation
EXW59_RS17225	COG0768	penicillin binding
EXW59_RS17230	COG0768	penicillin binding
EXW59_RS17265	COG1252	NADH dehydrogenase
EXW59_RS17270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS17270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS17285	COG0697	spore germination
EXW59_RS17310	COG3397	chitin binding
EXW59_RS17315	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_RS17325	COG1408	metallophosphoesterase
EXW59_RS17335	COG1131	(ABC) transporter
EXW59_RS17345	COG1309	transcriptional regulator
EXW59_RS17355	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS17360	COG0439	Biotin carboxylase
EXW59_RS17365	COG0511	ligase activity, forming carbon-carbon bonds
EXW59_RS17370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW59_RS17375	COG1024	Enoyl-CoA hydratase
EXW59_RS17380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW59_RS17385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_RS17425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS17430	COG0572	uridine kinase
EXW59_RS17435	COG2318	DinB family
EXW59_RS17465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_RS17490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW59_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS17520	COG1733	regulation of RNA biosynthetic process
EXW59_RS17540	COG1942	4-Oxalocrotonate Tautomerase
EXW59_RS17545	COG0583	DNA-binding transcription factor activity
EXW59_RS17555	COG1309	transcriptional regulator
EXW59_RS17585	COG0697	spore germination
EXW59_RS17590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS17620	COG2323	membrane
EXW59_RS17625	COG2132	Multicopper oxidase
EXW59_RS17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS17645	COG0697	spore germination
EXW59_RS17650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_RS17655	COG0201	protein transport
EXW59_RS17665	COG0737	Belongs to the 5'-nucleotidase family
EXW59_RS17670	COG3227	Zinc metalloprotease (Elastase)
EXW59_RS17675	COG1523	belongs to the glycosyl hydrolase 13 family
EXW59_RS17690	COG0076	glutamate decarboxylase activity
EXW59_RS17695	COG0657	acetylesterase activity
EXW59_RS17700	COG1073	alpha beta
EXW59_RS17710	COG0577	efflux transmembrane transporter activity
EXW59_RS17715	COG1136	(ABC) transporter
EXW59_RS17745	COG5002	protein histidine kinase activity
EXW59_RS17750	COG0745	RESPONSE REGULATOR receiver
EXW59_RS17760	COG1011	Hydrolase
EXW59_RS17785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_RS17790	COG1183	phosphatidylcholine synthase activity
EXW59_RS17800	COG1132	(ABC) transporter
EXW59_RS17805	COG3961	Belongs to the TPP enzyme family
EXW59_RS17825	COG0322	excinuclease ABC activity
EXW59_RS17850	COG2318	DinB family
EXW59_RS17865	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW59_RS17890	COG3878	Protein conserved in bacteria
EXW59_RS17915	COG1051	belongs to the nudix hydrolase family
EXW59_RS17920	COG0592	DNA-directed DNA polymerase activity
EXW59_RS17925	COG2816	NAD+ diphosphatase activity
EXW59_RS17935	COG2223	nitrite transmembrane transporter activity
EXW59_RS17975	COG0697	spore germination
EXW59_RS17980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS17995	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_RS18020	COG2814	Major facilitator Superfamily
EXW59_RS18030	COG1132	(ABC) transporter
EXW59_RS18030	COG2375	cellular response to nickel ion
EXW59_RS18035	COG1132	(ABC) transporter
EXW59_RS18070	COG0768	penicillin binding
EXW59_RS18075	COG0671	phosphoesterase, PA-phosphatase related
EXW59_RS18080	COG0604	alcohol dehydrogenase
EXW59_RS18085	COG5002	protein histidine kinase activity
EXW59_RS18090	COG0745	RESPONSE REGULATOR receiver
EXW59_RS18100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_RS18110	COG2205	protein histidine kinase activity
EXW59_RS18125	COG1122	ATPase activity
EXW59_RS18130	COG4720	Psort location CytoplasmicMembrane, score
EXW59_RS18135	COG1794	racemase activity, acting on amino acids and derivatives
EXW59_RS18140	COG1819	glycosyl
EXW59_RS18150	COG0768	penicillin binding
EXW59_RS18155	COG5002	protein histidine kinase activity
EXW59_RS18160	COG0561	phosphatase activity
EXW59_RS18205	COG2124	cytochrome p450
EXW59_RS18250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW59_RS18260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS18265	COG0460	homoserine dehydrogenase
EXW59_RS18285	COG0577	efflux transmembrane transporter activity
EXW59_RS18290	COG1136	(ABC) transporter
EXW59_RS18305	COG0488	(ABC) transporter
EXW59_RS18310	COG0667	Aldo Keto reductase
EXW59_RS18315	COG0583	DNA-binding transcription factor activity
EXW59_RS18325	COG2205	protein histidine kinase activity
EXW59_RS18330	COG0745	RESPONSE REGULATOR receiver
EXW59_RS18340	COG3773	Cell wall hydrolase
EXW59_RS18345	COG0604	alcohol dehydrogenase
EXW59_RS18380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS18395	COG2959	enzyme of heme biosynthesis
EXW59_RS18420	COG3483	tryptophan 2,3-dioxygenase activity
EXW59_RS18425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW59_RS18430	COG3844	kynureninase activity
EXW59_RS18435	COG1309	transcriptional regulator
EXW59_RS18450	COG3284	Transcriptional regulator
EXW59_RS18465	COG1349	DNA-binding transcription factor activity
EXW59_RS18485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW59_RS18490	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_RS18495	COG0022	dehydrogenase e1 component
EXW59_RS18500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS18525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_RS18525	COG0456	acetyltransferase
EXW59_RS18560	COG4176	ABC-type proline glycine betaine transport system permease component
EXW59_RS18565	COG0517	IMP dehydrogenase activity
EXW59_RS18565	COG4175	Glycine betaine
EXW59_RS18590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW59_RS18595	COG2153	protein acetylation
EXW59_RS18600	COG3397	chitin binding
EXW59_RS18610	COG1819	glycosyl
EXW59_RS18625	COG2205	protein histidine kinase activity
EXW59_RS18630	COG2315	Protein conserved in bacteria
EXW59_RS18685	COG3973	AAA domain
EXW59_RS18700	COG2105	PFAM AIG2 family protein
EXW59_RS18705	COG0514	ATP-dependent DNA helicase (RecQ)
EXW59_RS18730	COG4637	Psort location Cytoplasmic, score
EXW59_RS18745	COG1227	inorganic diphosphatase activity
EXW59_RS18750	COG3397	chitin binding
EXW59_RS18755	COG2318	DinB family
EXW59_RS18770	COG1162	GTPase activity
EXW59_RS18775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_RS18780	COG1115	amino acid carrier protein
EXW59_RS18785	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS18790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW59_RS18800	COG3938	Belongs to the proline racemase family
EXW59_RS18805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_RS18845	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS18860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW59_RS18865	COG4166	transmembrane transport
EXW59_RS18875	COG4948	Mandelate Racemase Muconate Lactonizing
EXW59_RS18895	COG0667	Aldo Keto reductase
EXW59_RS18945	COG2936	dipeptidyl-peptidase activity
EXW59_RS18955	COG0745	RESPONSE REGULATOR receiver
EXW59_RS18975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_RS18980	COG1164	Oligoendopeptidase f
EXW59_RS19005	COG1307	EDD domain protein, DegV family
EXW59_RS19030	COG1335	isochorismatase
EXW59_RS19045	COG2814	Major facilitator Superfamily
EXW59_RS19055	COG1664	Polymer-forming cytoskeletal
EXW59_RS19060	COG0789	Transcriptional regulator
EXW59_RS19065	COG4533	DNA binding
EXW59_RS19070	COG2814	Major facilitator Superfamily
EXW59_RS19070	COG0477	Major facilitator Superfamily
EXW59_RS19085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_RS19090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_RS19095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_RS19100	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS19115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_RS19120	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS19125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_RS19140	COG2261	transglycosylase associated protein
EXW59_RS19155	COG2226	methyltransferase
EXW59_RS19190	COG0436	Aminotransferase
EXW59_RS19195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW59_RS19225	COG1131	(ABC) transporter
EXW59_RS19230	COG2188	Transcriptional regulator
EXW59_RS19275	COG0628	permease
EXW59_RS19305	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW59_RS19315	COG0697	spore germination
EXW59_RS19320	COG2318	DinB family
EXW59_RS19370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_RS19380	COG2814	Major facilitator Superfamily
EXW59_RS19385	COG1368	sulfuric ester hydrolase activity
EXW59_RS19395	COG0488	(ABC) transporter
EXW59_RS19400	COG1033	growth of symbiont in host cell
EXW59_RS19400	COG2409	Drug exporters of the RND superfamily
EXW59_RS19405	COG1309	transcriptional regulator
EXW59_RS19425	COG0287	Prephenate dehydrogenase
EXW59_RS19440	COG1605	Chorismate mutase
EXW59_RS19440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW59_RS19465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW59_RS19480	COG1388	LysM domain
EXW59_RS19480	COG3584	3D domain protein
EXW59_RS19490	COG0346	lactoylglutathione lyase activity
EXW59_RS19500	COG0431	NADPH-dependent FMN reductase
EXW59_RS19530	COG0579	oxidoreductase
EXW59_RS19535	COG1879	ABC-type sugar transport system periplasmic component
EXW59_RS19550	COG1129	ABC transporter
EXW59_RS19555	COG2390	Transcriptional regulator
EXW59_RS19570	COG1830	Aldolase
EXW59_RS19585	COG0346	lactoylglutathione lyase activity
EXW59_RS19590	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_RS19620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS19630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW59_RS19635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW59_RS19640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_RS19645	COG3239	Fatty acid desaturase
EXW59_RS19660	COG3655	Transcriptional regulator
EXW59_RS19705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS19710	COG0346	lactoylglutathione lyase activity
EXW59_RS19735	COG0714	Associated with various cellular activities
EXW59_RS19755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW59_RS19760	COG0753	catalase activity
EXW59_RS19770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW59_RS19795	COG0714	Associated with various cellular activities
EXW59_RS19805	COG0778	Nitroreductase
EXW59_RS19810	COG1846	Transcriptional regulator
EXW59_RS19830	COG4884	unkown
EXW59_RS19830	COG3831	ATPase activity
EXW59_RS19840	COG1136	(ABC) transporter
EXW59_RS19870	COG2207	Transcriptional regulator
EXW59_RS19875	COG0456	acetyltransferase
EXW59_RS19895	COG0697	spore germination
EXW59_RS19900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS19905	COG1671	Belongs to the UPF0178 family
EXW59_RS19925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_RS19925	COG0456	acetyltransferase
EXW59_RS19950	COG0730	response to heat
EXW59_RS19960	COG0833	amino acid
EXW59_RS19970	COG4335	DNA alkylation repair
EXW59_RS19995	COG0681	Belongs to the peptidase S26 family
EXW59_RS20000	COG0768	penicillin binding
EXW59_RS20010	COG3104	oligopeptide transport
EXW59_RS20015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW59_RS20030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW59_RS20035	COG1984	allophanate hydrolase subunit 2
EXW59_RS20040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW59_RS20045	COG1414	Transcriptional regulator
EXW59_RS20075	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS20090	COG0346	lactoylglutathione lyase activity
EXW59_RS20100	COG0640	Transcriptional regulator
EXW59_RS20110	COG3314	Sporulation integral membrane protein YlbJ
EXW59_RS20135	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW59_RS20150	COG0574	Belongs to the PEP-utilizing enzyme family
EXW59_RS20150	COG3848	Pyruvate phosphate dikinase
EXW59_RS20160	COG0572	uridine kinase
EXW59_RS20175	COG1136	(ABC) transporter
EXW59_RS20205	COG1073	alpha beta
EXW59_RS20255	COG5002	protein histidine kinase activity
EXW59_RS20260	COG0745	RESPONSE REGULATOR receiver
EXW59_RS20270	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW59_RS20285	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW59_RS20290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW59_RS20295	COG1121	(ABC) transporter
EXW59_RS20310	COG1999	signal sequence binding
EXW59_RS20315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW59_RS20320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW59_RS20350	COG0798	PFAM Bile acid sodium symporter
EXW59_RS20355	COG0346	lactoylglutathione lyase activity
EXW59_RS20360	COG0640	Transcriptional regulator
EXW59_RS20380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_RS20380	COG3320	Male sterility
EXW59_RS20385	COG1309	transcriptional regulator
EXW59_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS20395	COG1522	sequence-specific DNA binding
EXW59_RS20410	COG0346	lactoylglutathione lyase activity
EXW59_RS20435	COG2226	methyltransferase
EXW59_RS20445	COG2814	Major facilitator Superfamily
EXW59_RS20480	COG0745	RESPONSE REGULATOR receiver
EXW59_RS20485	COG3850	Histidine kinase
EXW59_RS20485	COG5002	protein histidine kinase activity
EXW59_RS20515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW59_RS20545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW59_RS20565	COG1136	(ABC) transporter
EXW59_RS20570	COG0577	efflux transmembrane transporter activity
EXW59_RS20590	COG3850	Histidine kinase
EXW59_RS20590	COG5002	protein histidine kinase activity
EXW59_RS20605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS20620	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_RS20640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW59_RS20695	COG2814	Major facilitator Superfamily
EXW59_RS20725	COG5444	nuclease activity
EXW59_RS20800	COG2849	repeat protein
EXW59_RS20805	COG5444	nuclease activity
EXW59_RS20845	COG0477	Major facilitator Superfamily
EXW59_RS20860	COG1846	Transcriptional regulator
EXW59_RS20865	COG2814	Major facilitator Superfamily
EXW59_RS20880	COG0789	Transcriptional regulator
EXW59_RS20915	COG1476	TRANSCRIPTIONal
EXW59_RS20930	COG1288	antiporter activity
EXW59_RS20935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW59_RS20980	COG3718	enzyme involved in inositol metabolism
EXW59_RS21010	COG0673	inositol 2-dehydrogenase activity
EXW59_RS21015	COG2814	Major facilitator Superfamily
EXW59_RS21020	COG1609	Transcriptional regulator
EXW59_RS21130	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS21145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS21205	COG4187	Peptidase family M20/M25/M40
EXW59_RS21210	COG1414	Transcriptional regulator
EXW59_RS21215	COG0833	amino acid
EXW59_RS21230	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW59_RS21235	COG2031	fatty acid transporter
EXW59_RS21245	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_RS21300	COG1288	antiporter activity
EXW59_RS21305	COG2356	endonuclease I
EXW59_RS21310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_RS21325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW59_RS21350	COG1785	Belongs to the alkaline phosphatase family
EXW59_RS21355	COG0778	Nitroreductase
EXW59_RS21360	COG1733	regulation of RNA biosynthetic process
EXW59_RS21380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS21390	COG1131	(ABC) transporter
EXW59_RS21420	COG1595	DNA-templated transcription, initiation
EXW59_RS21435	COG1011	Hydrolase
EXW59_RS21440	COG2365	Tyrosine phosphatase family
EXW59_RS21460	COG0346	lactoylglutathione lyase activity
EXW59_RS21465	COG1940	carbohydrate kinase activity
EXW59_RS21470	COG0738	Major facilitator superfamily
EXW59_RS21475	COG0110	maltose O-acetyltransferase activity
EXW59_RS21490	COG0628	permease
EXW59_RS21495	COG2261	transglycosylase associated protein
EXW59_RS21535	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW59_RS21545	COG1253	flavin adenine dinucleotide binding
EXW59_RS21550	COG0789	Transcriptional regulator
EXW59_RS21555	COG0697	spore germination
EXW59_RS21565	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW59_RS21570	COG3813	Protein conserved in bacteria
EXW59_RS21575	COG2706	6-phosphogluconolactonase activity
EXW59_RS21580	COG1070	Carbohydrate kinase
EXW59_RS21590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW59_RS21595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW59_RS21600	COG4702	Belongs to the UPF0303 family
EXW59_RS21610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS21630	COG0384	phenazine biosynthesis protein PhzF
EXW59_RS21650	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS21655	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_RS21660	COG1733	regulation of RNA biosynthetic process
EXW59_RS21675	COG1191	sigma factor activity
EXW59_RS21700	COG1876	peptidase activity
EXW59_RS21745	COG0741	lytic transglycosylase activity
EXW59_RS21775	COG5002	protein histidine kinase activity
EXW59_RS21775	COG3850	Histidine kinase
EXW59_RS21780	COG0745	RESPONSE REGULATOR receiver
EXW59_RS21795	COG0657	acetylesterase activity
EXW59_RS21805	COG2814	Major facilitator Superfamily
EXW59_RS21810	COG1309	transcriptional regulator
EXW59_RS21820	COG3226	Transcriptional regulator
EXW59_RS21825	COG1280	lysine exporter protein (LysE YggA)
EXW59_RS21845	COG0814	amino acid
EXW59_RS21870	COG1151	hydroxylamine reductase activity
EXW59_RS21900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_RS21910	COG2072	flavoprotein involved in K transport
EXW59_RS21950	COG0604	alcohol dehydrogenase
EXW59_RS21955	COG1113	amino acid transport
EXW59_RS21965	COG2814	Major facilitator Superfamily
EXW59_RS21975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_RS21980	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS21990	COG0534	Mate efflux family protein
EXW59_RS21995	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS22000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_RS22015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_RS22020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_RS22040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS22045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS22050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS22055	COG3739	integral membrane protein
EXW59_RS22075	COG0583	DNA-binding transcription factor activity
EXW59_RS22100	COG1193	negative regulation of DNA recombination
EXW59_RS22120	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW59_RS22125	COG1164	Oligoendopeptidase f
EXW59_RS22140	COG0789	Transcriptional regulator
EXW59_RS22140	COG4978	Transcriptional regulator
EXW59_RS22150	COG3781	membrane
EXW59_RS22160	COG2957	Belongs to the agmatine deiminase family
EXW59_RS22165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_RS22205	COG3973	AAA domain
EXW59_RS22215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW59_RS22220	COG0640	Transcriptional regulator
EXW59_RS22225	COG0604	alcohol dehydrogenase
EXW59_RS22230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW59_RS22240	COG0457	Tetratricopeptide repeat
EXW59_RS22245	COG2808	Putative FMN-binding domain
EXW59_RS22250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_RS22260	COG0277	FAD linked oxidase domain protein
EXW59_RS22270	COG0825	malonyl-CoA metabolic process
EXW59_RS22300	COG1285	pathogenesis
EXW59_RS22310	COG2514	catechol 2,3-dioxygenase activity
EXW59_RS22315	COG2720	vancomycin resistance protein
EXW59_RS22340	COG1278	Cold shock
EXW59_RS22350	COG0716	FMN binding
EXW59_RS22360	COG0494	nUDIX hydrolase
EXW59_RS22380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS22390	COG0165	Argininosuccinate lyase
EXW59_RS22405	COG4145	pantothenate transmembrane transporter activity
EXW59_RS22415	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS22430	COG1657	PFAM Prenyltransferase squalene oxidase
EXW59_RS22435	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW59_RS22440	COG2962	Rard protein
EXW59_RS22445	COG3326	Membrane
EXW59_RS22475	COG2226	methyltransferase
EXW59_RS22480	COG4166	transmembrane transport
EXW59_RS22485	COG4166	transmembrane transport
EXW59_RS22490	COG4166	transmembrane transport
EXW59_RS22495	COG1316	TRANSCRIPTIONal
EXW59_RS22505	COG1595	DNA-templated transcription, initiation
EXW59_RS22515	COG1131	(ABC) transporter
EXW59_RS22535	COG0673	inositol 2-dehydrogenase activity
EXW59_RS22540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW59_RS22545	COG0187	DNA topoisomerase II activity
EXW59_RS22550	COG1832	CoA-binding protein
EXW59_RS22555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_RS22560	COG0745	RESPONSE REGULATOR receiver
EXW59_RS22570	COG1328	CTP reductase activity
EXW59_RS22570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW59_RS22580	COG4841	protein insertion into membrane
EXW59_RS22585	COG0824	Thioesterase
EXW59_RS22610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS22625	COG1132	(ABC) transporter
EXW59_RS22630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW59_RS22660	COG2211	Major facilitator Superfamily
EXW59_RS22670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_RS22685	COG0183	Belongs to the thiolase family
EXW59_RS22690	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS22695	COG1268	BioY protein
EXW59_RS22700	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS22715	COG1396	sequence-specific DNA binding
EXW59_RS22760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS22770	COG5002	protein histidine kinase activity
EXW59_RS22780	COG0400	carboxylic ester hydrolase activity
EXW59_RS22785	COG0346	lactoylglutathione lyase activity
EXW59_RS22795	COG0069	glutamate synthase activity
EXW59_RS22800	COG1902	pentaerythritol trinitrate reductase activity
EXW59_RS22810	COG1329	Transcriptional regulator
EXW59_RS22815	COG0010	Belongs to the arginase family
EXW59_RS22820	COG1228	amidohydrolase
EXW59_RS22825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW59_RS22830	COG2986	histidine ammonia-lyase
EXW59_RS22840	COG2226	methyltransferase
EXW59_RS22865	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW59_RS22870	COG0785	Cytochrome C biogenesis protein
EXW59_RS22880	COG1473	amidohydrolase
EXW59_RS22885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_RS22890	COG1131	(ABC) transporter
EXW59_RS22900	COG0583	DNA-binding transcription factor activity
EXW59_RS22910	COG1346	cytolysis
EXW59_RS22925	COG0730	response to heat
EXW59_RS22935	COG3409	Peptidoglycan-binding domain 1 protein
EXW59_RS22935	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW59_RS22955	COG1132	(ABC) transporter
EXW59_RS22960	COG1132	(ABC) transporter
EXW59_RS22965	COG3763	UPF0154 protein
EXW59_RS22985	COG3639	organic phosphonate transmembrane transporter activity
EXW59_RS22995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_RS23000	COG0737	Belongs to the 5'-nucleotidase family
EXW59_RS23010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW59_RS23015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW59_RS23030	COG1695	Transcriptional regulator
EXW59_RS23035	COG1132	(ABC) transporter
EXW59_RS23065	COG0367	asparagine synthase
EXW59_RS23070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_RS23080	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW59_RS23085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW59_RS23100	COG3420	alginic acid biosynthetic process
EXW59_RS23100	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW59_RS23105	COG1216	Glycosyl transferase, family 2
EXW59_RS23105	COG1442	glycosyl transferase family 8
EXW59_RS23130	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS23140	COG1215	transferase activity, transferring glycosyl groups
EXW59_RS23145	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS23150	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS23155	COG1086	Polysaccharide biosynthesis protein
EXW59_RS23160	COG0489	protein tyrosine kinase activity
EXW59_RS23165	COG3944	biosynthesis protein
EXW59_RS23170	COG0174	glutamine synthetase
EXW59_RS23175	COG0789	Transcriptional regulator
EXW59_RS23180	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW59_RS23185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW59_RS23190	COG2860	membrane
EXW59_RS23200	COG0464	growth
EXW59_RS23220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW59_RS23230	COG1388	LysM domain
EXW59_RS23230	COG3584	3D domain protein
EXW59_RS23235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW59_RS23235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW59_RS23235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_RS23240	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW59_RS23245	COG1349	DNA-binding transcription factor activity
EXW59_RS23250	COG1979	alcohol dehydrogenase
EXW59_RS23255	COG2322	membrane
EXW59_RS23265	COG1113	amino acid transport
EXW59_RS23275	COG1473	amidohydrolase
EXW59_RS23280	COG1408	metallophosphoesterase
EXW59_RS23285	COG2116	formate transmembrane transporter activity
EXW59_RS23300	COG2217	Heavy metal translocating P-type atpase
EXW59_RS23305	COG2608	mercury ion transmembrane transporter activity
EXW59_RS23310	COG1937	Protein conserved in bacteria
EXW59_RS23330	COG2819	hydrolase of the alpha beta superfamily
EXW59_RS23335	COG1120	ATPase activity
EXW59_RS23340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS23345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS23350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS23355	COG0708	Exodeoxyribonuclease III
EXW59_RS23360	COG2169	Transcriptional regulator
EXW59_RS23365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW59_RS23370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW59_RS23375	COG2706	6-phosphogluconolactonase activity
EXW59_RS23380	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_RS23385	COG2364	Membrane
EXW59_RS23395	COG0346	lactoylglutathione lyase activity
EXW59_RS23400	COG5001	Diguanylate cyclase
EXW59_RS23400	COG3300	MHYT domain
EXW59_RS23420	COG1086	Polysaccharide biosynthesis protein
EXW59_RS23440	COG1346	cytolysis
EXW59_RS23450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_RS23455	COG0596	Alpha beta hydrolase
EXW59_RS23455	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_RS23460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_RS23470	COG2188	Transcriptional regulator
EXW59_RS23475	COG2723	6-phospho-beta-galactosidase activity
EXW59_RS23480	COG0840	transmembrane signaling receptor activity
EXW59_RS23490	COG3773	Cell wall hydrolase
EXW59_RS23500	COG1368	sulfuric ester hydrolase activity
EXW59_RS23505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_RS23515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW59_RS23520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW59_RS23525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW59_RS23535	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW59_RS23540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW59_RS23545	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW59_RS23550	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW59_RS23550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW59_RS23560	COG2359	stage V sporulation protein S
EXW59_RS23565	COG1692	metallophosphoesterase
EXW59_RS23570	COG1418	mRNA catabolic process
EXW59_RS23575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW59_RS23580	COG1058	Belongs to the CinA family
EXW59_RS23580	COG1546	Belongs to the CinA family
EXW59_RS23585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW59_RS23590	COG1426	Protein conserved in bacteria
EXW59_RS23605	COG0300	oxidoreductase activity
EXW59_RS23610	COG0612	Peptidase, M16
EXW59_RS23615	COG0612	Peptidase, M16
EXW59_RS23620	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW59_RS23625	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW59_RS23630	COG3845	ABC transporter
EXW59_RS23635	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW59_RS23640	COG2188	Transcriptional regulator
EXW59_RS23645	COG1674	ftsk spoiiie
EXW59_RS23655	COG0740	serine-type endopeptidase activity
EXW59_RS23660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW59_RS23670	COG0527	aspartate kinase activity
EXW59_RS23675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW59_RS23680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW59_RS23685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW59_RS23690	COG1873	PFAM PRC-barrel domain
EXW59_RS23695	COG0612	Peptidase, M16
EXW59_RS23700	COG0726	polysaccharide deacetylase
EXW59_RS23705	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW59_RS23715	COG0196	riboflavin kinase activity
EXW59_RS23725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW59_RS23730	COG1550	Protein conserved in bacteria
EXW59_RS23735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW59_RS23740	COG1358	cellular component organization or biogenesis
EXW59_RS23745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW59_RS23750	COG0195	Participates in both transcription termination and antitermination
EXW59_RS23755	COG0779	Required for maturation of 30S ribosomal subunits
EXW59_RS23765	COG0442	prolyl-tRNA aminoacylation
EXW59_RS23770	COG0750	zinc metalloprotease
EXW59_RS23780	COG4589	Belongs to the CDS family
EXW59_RS23790	COG0233	cytoplasmic translational termination
EXW59_RS23795	COG0528	UMP kinase activity
EXW59_RS23800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW59_RS23805	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW59_RS23810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW59_RS23815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW59_RS23820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW59_RS23825	COG4974	Belongs to the 'phage' integrase family
EXW59_RS23830	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW59_RS23835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW59_RS23840	COG0758	DNA mediated transformation
EXW59_RS23845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW59_RS23850	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW59_RS23855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW59_RS23870	COG0335	large ribosomal subunit rRNA binding
EXW59_RS23875	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW59_RS23880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW59_RS23885	COG1837	Belongs to the UPF0109 family
EXW59_RS23895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW59_RS23900	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW59_RS23905	COG0552	protein localization to endoplasmic reticulum
EXW59_RS23910	COG1196	nuclear chromosome segregation
EXW59_RS23915	COG0571	ribonuclease III activity
EXW59_RS23920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_RS23925	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS23930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW59_RS23935	COG0416	fatty acid biosynthetic process
EXW59_RS23940	COG1349	DNA-binding transcription factor activity
EXW59_RS23940	COG2050	protein possibly involved in aromatic compounds catabolism
EXW59_RS23945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW59_RS23950	COG1461	Dihydroxyacetone kinase
EXW59_RS23955	COG1302	Protein conserved in bacteria
EXW59_RS23970	COG1564	THIamine pyrophosphokinase
EXW59_RS23975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW59_RS23985	COG0515	serine threonine protein kinase
EXW59_RS23985	COG2815	serine threonine protein kinase
EXW59_RS23990	COG0631	protein serine/threonine phosphatase activity
EXW59_RS23995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW59_RS24000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW59_RS24000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW59_RS24005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW59_RS24010	COG0242	peptide deformylase activity
EXW59_RS24015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW59_RS24020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW59_RS24025	COG1758	RNA polymerase activity
EXW59_RS24040	COG1561	YicC-like family, N-terminal region
EXW59_RS24045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW59_RS24060	COG0006	proline dipeptidase activity
EXW59_RS24080	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW59_RS24100	COG0167	dihydroorotate dehydrogenase activity
EXW59_RS24105	COG0543	2 iron, 2 sulfur cluster binding
EXW59_RS24110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW59_RS24120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW59_RS24125	COG0540	Belongs to the ATCase OTCase family
EXW59_RS24135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW59_RS24140	COG0564	pseudouridine synthase activity
EXW59_RS24145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW59_RS24155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW59_RS24160	COG3599	regulation of cell shape
EXW59_RS24165	COG2302	S4 RNA-binding domain
EXW59_RS24170	COG0762	integral membrane protein
EXW59_RS24175	COG1799	cell septum assembly
EXW59_RS24180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW59_RS24190	COG1873	PFAM PRC-barrel domain
EXW59_RS24195	COG1191	sigma factor activity
EXW59_RS24200	COG1191	sigma factor activity
EXW59_RS24210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW59_RS24215	COG0849	cell division
EXW59_RS24220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW59_RS24235	COG0772	Belongs to the SEDS family
EXW59_RS24240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW59_RS24245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW59_RS24250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW59_RS24255	COG0768	penicillin binding
EXW59_RS24260	COG0768	penicillin binding
EXW59_RS24270	COG0275	rRNA processing
EXW59_RS24275	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW59_RS24280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW59_RS24285	COG0454	-acetyltransferase
EXW59_RS24295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW59_RS24300	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW59_RS24410	COG0740	serine-type endopeptidase activity
EXW59_RS24420	COG4626	Terminase
EXW59_RS24420	COG1802	Transcriptional regulator
EXW59_RS24470	COG0582	viral genome integration into host DNA
EXW59_RS24530	COG2002	toxin-antitoxin pair type II binding
EXW59_RS24540	COG1484	DNA-dependent DNA replication
EXW59_RS24570	COG3620	sequence-specific DNA binding
EXW59_RS24590	COG1396	sequence-specific DNA binding
EXW59_RS24615	COG0582	viral genome integration into host DNA
EXW59_RS24620	COG1323	Belongs to the UPF0348 family
EXW59_RS24625	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW59_RS24630	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW59_RS24635	COG3314	Sporulation integral membrane protein YlbJ
EXW59_RS24645	COG0742	ribosomal rna small subunit methyltransferase
EXW59_RS24655	COG4471	UPF0298 protein
EXW59_RS24660	COG3679	Belongs to the UPF0342 family
EXW59_RS24665	COG0406	alpha-ribazole phosphatase activity
EXW59_RS24680	COG2340	Cysteine-rich secretory protein family
EXW59_RS24690	COG3336	cytochrome c oxidase
EXW59_RS24715	COG0109	protoheme IX farnesyltransferase activity
EXW59_RS24720	COG1612	heme a metabolic process
EXW59_RS24725	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW59_RS24730	COG0772	Belongs to the SEDS family
EXW59_RS24735	COG4838	Belongs to the UPF0358 family
EXW59_RS24740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW59_RS24745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW59_RS24755	COG4896	Protein conserved in bacteria
EXW59_RS24770	COG1217	gtp-binding protein TYPA
EXW59_RS24780	COG0483	inositol monophosphate 1-phosphatase activity
EXW59_RS24790	COG4493	Belongs to the UPF0637 family
EXW59_RS24795	COG4476	Belongs to the UPF0223 family
EXW59_RS24800	COG1982	Orn Lys Arg decarboxylase major
EXW59_RS24845	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_RS24850	COG0022	dehydrogenase e1 component
EXW59_RS24855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_RS24870	COG0561	phosphatase activity
EXW59_RS24875	COG5503	Protein of unknown function (DUF1447)
EXW59_RS24880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW59_RS24885	COG0569	domain protein
EXW59_RS24895	COG1473	amidohydrolase
EXW59_RS24900	COG2171	N-acyltransferase activity
EXW59_RS24905	COG0583	DNA-binding transcription factor activity
EXW59_RS24910	COG0517	IMP dehydrogenase activity
EXW59_RS24920	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW59_RS24930	COG4703	Protein of unknown function (DUF1797)
EXW59_RS24945	COG2200	EAL domain
EXW59_RS24950	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS24955	COG1408	metallophosphoesterase
EXW59_RS25000	COG2814	Major facilitator Superfamily
EXW59_RS25010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW59_RS25020	COG3209	COG3209 Rhs family protein
EXW59_RS25030	COG2205	protein histidine kinase activity
EXW59_RS25040	COG0436	Aminotransferase
EXW59_RS25045	COG1609	Transcriptional regulator
EXW59_RS25050	COG3833	ABC-type maltose transport systems, permease component
EXW59_RS25055	COG1175	transmembrane transport
EXW59_RS25060	COG2182	Extracellular solute-binding protein
EXW59_RS25070	COG0366	Alpha amylase catalytic
EXW59_RS25075	COG3842	ATPase activity
EXW59_RS25120	COG0183	Belongs to the thiolase family
EXW59_RS25150	COG1695	Transcriptional regulator
EXW59_RS25155	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS25165	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW59_RS25170	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW59_RS25175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW59_RS25180	COG0436	Aminotransferase
EXW59_RS25185	COG1850	ribulose-bisphosphate carboxylase activity
EXW59_RS25190	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW59_RS25195	COG0235	Class ii aldolase
EXW59_RS25200	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW59_RS25215	COG2084	Dehydrogenase
EXW59_RS25225	COG2199	diguanylate cyclase activity
EXW59_RS25230	COG0778	Nitroreductase
EXW59_RS25255	COG1263	PTS System
EXW59_RS25255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_RS25255	COG2190	(PTS) system
EXW59_RS25260	COG3711	transcriptional antiterminator
EXW59_RS25270	COG2188	Transcriptional regulator
EXW59_RS25275	COG0363	glucosamine-6-phosphate deaminase activity
EXW59_RS25280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW59_RS25290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW59_RS25295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW59_RS25305	COG1547	Domain of unknown function (DUF309)
EXW59_RS25315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW59_RS25320	COG4086	secreted protein
EXW59_RS25325	COG0561	phosphatase activity
EXW59_RS25330	COG0697	spore germination
EXW59_RS25345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_RS25370	COG0733	neurotransmitter:sodium symporter activity
EXW59_RS25390	COG1686	Belongs to the peptidase S11 family
EXW59_RS25395	COG1725	Transcriptional regulator
EXW59_RS25400	COG1131	(ABC) transporter
EXW59_RS25420	COG1846	Transcriptional regulator
EXW59_RS25435	COG0598	Magnesium transport protein CorA
EXW59_RS25450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW59_RS25460	COG4974	Belongs to the 'phage' integrase family
EXW59_RS25470	COG0735	belongs to the Fur family
EXW59_RS25475	COG1300	Membrane
EXW59_RS25495	COG0667	Aldo Keto reductase
EXW59_RS25500	COG0656	L-ascorbic acid biosynthetic process
EXW59_RS25505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_RS25505	COG0456	acetyltransferase
EXW59_RS25515	COG0737	Belongs to the 5'-nucleotidase family
EXW59_RS25515	COG1525	nuclease
EXW59_RS25515	COG4085	toxin activity
EXW59_RS25520	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW59_RS25530	COG0596	Alpha beta hydrolase
EXW59_RS25535	COG2056	Na+-H+ antiporter family
EXW59_RS25540	COG1609	Transcriptional regulator
EXW59_RS25545	COG0456	acetyltransferase
EXW59_RS25550	COG1073	alpha beta
EXW59_RS25565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW59_RS25565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW59_RS25570	COG0307	riboflavin synthase, alpha
EXW59_RS25575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW59_RS25575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW59_RS25590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW59_RS25595	COG4106	trans-aconitate 2-methyltransferase activity
EXW59_RS25600	COG2226	methyltransferase
EXW59_RS25600	COG1073	alpha beta
EXW59_RS25605	COG0156	8-amino-7-oxononanoate synthase activity
EXW59_RS25615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_RS25625	COG1757	Na H antiporter
EXW59_RS25630	COG0737	Belongs to the 5'-nucleotidase family
EXW59_RS25640	COG1522	sequence-specific DNA binding
EXW59_RS25675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW59_RS25685	COG0300	oxidoreductase activity
EXW59_RS25690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS25695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_RS25700	COG1760	l-serine dehydratase
EXW59_RS25705	COG1760	l-serine dehydratase
EXW59_RS25715	COG1234	tRNA 3'-trailer cleavage
EXW59_RS25730	COG1285	pathogenesis
EXW59_RS25745	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_RS25750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS25765	COG1376	ErfK ybiS ycfS ynhG family protein
EXW59_RS25770	COG4129	membrane
EXW59_RS25775	COG1126	abc transporter atp-binding protein
EXW59_RS25780	COG0765	amino acid transport
EXW59_RS25785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_RS25800	COG2816	NAD+ diphosphatase activity
EXW59_RS25805	COG2323	membrane
EXW59_RS25810	COG0772	Belongs to the SEDS family
EXW59_RS25815	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_RS25820	COG0022	dehydrogenase e1 component
EXW59_RS25825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_RS25830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW59_RS25835	COG3426	butyrate kinase activity
EXW59_RS25845	COG0280	phosphate acetyltransferase
EXW59_RS25850	COG3829	transcription factor binding
EXW59_RS25850	COG3290	protein histidine kinase activity
EXW59_RS25860	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_RS25865	COG3093	addiction module antidote protein HigA
EXW59_RS25900	COG0745	RESPONSE REGULATOR receiver
EXW59_RS25905	COG0750	zinc metalloprotease
EXW59_RS25910	COG0497	DNA recombination
EXW59_RS25915	COG1438	arginine binding
EXW59_RS25920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW59_RS25925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW59_RS25930	COG0142	geranyltranstransferase activity
EXW59_RS25935	COG1722	exodeoxyribonuclease VII activity
EXW59_RS25940	COG1570	exodeoxyribonuclease VII activity
EXW59_RS25945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW59_RS25950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW59_RS25955	COG1302	Protein conserved in bacteria
EXW59_RS25960	COG0439	Biotin carboxylase
EXW59_RS25965	COG0511	ligase activity, forming carbon-carbon bonds
EXW59_RS26010	COG3854	ATPases associated with a variety of cellular activities
EXW59_RS26030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW59_RS26035	COG0006	proline dipeptidase activity
EXW59_RS26040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW59_RS26050	COG3872	metal-dependent enzyme
EXW59_RS26060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW59_RS26065	COG1321	iron dependent repressor
EXW59_RS26095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS26105	COG1609	Transcriptional regulator
EXW59_RS26115	COG2076	Multidrug Resistance protein
EXW59_RS26120	COG2076	Multidrug Resistance protein
EXW59_RS26155	COG1725	Transcriptional regulator
EXW59_RS26170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW59_RS26175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW59_RS26180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW59_RS26185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_RS26210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW59_RS26235	COG4970	Tfp pilus assembly protein FimT
EXW59_RS26245	COG1459	type II secretion system
EXW59_RS26250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW59_RS26305	COG0646	methionine synthase
EXW59_RS26305	COG1410	methionine synthase
EXW59_RS26310	COG0646	methionine synthase
EXW59_RS26310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW59_RS26315	COG0626	cystathionine gamma-synthase activity
EXW59_RS26320	COG0626	cystathionine gamma-synthase activity
EXW59_RS26335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS26345	COG1940	carbohydrate kinase activity
EXW59_RS26350	COG4483	Protein conserved in bacteria
EXW59_RS26355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW59_RS26360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW59_RS26365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW59_RS26370	COG0704	Plays a role in the regulation of phosphate uptake
EXW59_RS26380	COG0581	inorganic phosphate transmembrane transporter activity
EXW59_RS26385	COG0573	inorganic phosphate transmembrane transporter activity
EXW59_RS26390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW59_RS26395	COG0768	penicillin binding
EXW59_RS26400	COG0477	Major facilitator Superfamily
EXW59_RS26405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_RS26425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW59_RS26430	COG0735	belongs to the Fur family
EXW59_RS26435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW59_RS26440	COG1121	(ABC) transporter
EXW59_RS26445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS26455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW59_RS26470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW59_RS26475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW59_RS26480	COG2384	SAM-dependent methyltransferase
EXW59_RS26490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW59_RS26495	COG0358	DNA primase activity
EXW59_RS26505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW59_RS26510	COG0517	IMP dehydrogenase activity
EXW59_RS26515	COG1381	Involved in DNA repair and RecF pathway recombination
EXW59_RS26525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW59_RS26530	COG0295	cytidine deaminase activity
EXW59_RS26535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW59_RS26540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW59_RS26545	COG1480	7TM receptor with intracellular HD hydrolase
EXW59_RS26550	COG1702	phosphate starvation-inducible protein PhoH
EXW59_RS26565	COG1610	YqeY-like protein
EXW59_RS26570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW59_RS26575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW59_RS26580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW59_RS26590	COG0484	heat shock protein binding
EXW59_RS26595	COG0443	Heat shock 70 kDa protein
EXW59_RS26605	COG1420	regulation of RNA biosynthetic process
EXW59_RS26610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW59_RS26615	COG1733	regulation of RNA biosynthetic process
EXW59_RS26620	COG0481	GTPase activity
EXW59_RS26630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW59_RS26635	COG0268	Binds directly to 16S ribosomal RNA
EXW59_RS26640	COG1466	dna polymerase III delta subunit
EXW59_RS26650	COG0658	competence protein
EXW59_RS26650	COG2333	competence protein COMEC
EXW59_RS26655	COG2131	deaminase
EXW59_RS26660	COG1596	polysaccharide export
EXW59_RS26660	COG1555	photosystem II stabilization
EXW59_RS26665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_RS26670	COG2226	methyltransferase
EXW59_RS26675	COG0799	negative regulation of ribosome biogenesis
EXW59_RS26680	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW59_RS26685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW59_RS26690	COG1534	Rna-binding protein
EXW59_RS26695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW59_RS26700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW59_RS26705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW59_RS26715	COG0688	phosphatidylethanolamine metabolic process
EXW59_RS26725	COG1595	DNA-templated transcription, initiation
EXW59_RS26730	COG2357	RelA SpoT domain protein
EXW59_RS26740	COG1785	Belongs to the alkaline phosphatase family
EXW59_RS26750	COG2267	carboxylic ester hydrolase activity
EXW59_RS26785	COG1404	Belongs to the peptidase S8 family
EXW59_RS26790	COG3186	Phenylalanine-4-hydroxylase
EXW59_RS26795	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW59_RS26800	COG2514	catechol 2,3-dioxygenase activity
EXW59_RS26805	COG2259	Doxx family
EXW59_RS26845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS26855	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_RS26855	COG1454	alcohol dehydrogenase
EXW59_RS26860	COG0626	cystathionine gamma-synthase activity
EXW59_RS26865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_RS26870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_RS26875	COG2226	methyltransferase
EXW59_RS26890	COG0768	penicillin binding
EXW59_RS26895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW59_RS26900	COG0572	uridine kinase
EXW59_RS26905	COG0826	peptidase U32
EXW59_RS26910	COG0826	peptidase U32
EXW59_RS26915	COG4122	O-methyltransferase activity
EXW59_RS26920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW59_RS26930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW59_RS26935	COG4472	Bacterial protein of unknown function (DUF965)
EXW59_RS26940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_RS26950	COG0628	permease
EXW59_RS26970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW59_RS26980	COG0482	sulfurtransferase activity
EXW59_RS26985	COG1104	cysteine desulfurase activity
EXW59_RS26990	COG1959	2 iron, 2 sulfur cluster binding
EXW59_RS26995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW59_RS27005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW59_RS27010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW59_RS27025	COG1490	D-aminoacyl-tRNA deacylase activity
EXW59_RS27030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW59_RS27035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_RS27040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW59_RS27040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW59_RS27045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_RS27050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW59_RS27050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW59_RS27060	COG2244	polysaccharide biosynthetic process
EXW59_RS27065	COG2323	membrane
EXW59_RS27075	COG1862	Preprotein translocase
EXW59_RS27080	COG0343	queuine tRNA-ribosyltransferase activity
EXW59_RS27085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW59_RS27095	COG2255	four-way junction helicase activity
EXW59_RS27100	COG0632	four-way junction helicase activity
EXW59_RS27105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW59_RS27130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW59_RS27135	COG0157	Belongs to the NadC ModD family
EXW59_RS27140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW59_RS27145	COG1104	cysteine desulfurase activity
EXW59_RS27150	COG1827	regulation of RNA biosynthetic process
EXW59_RS27155	COG2258	MOSC domain
EXW59_RS27160	COG0077	Prephenate dehydratase
EXW59_RS27165	COG0577	efflux transmembrane transporter activity
EXW59_RS27170	COG0577	efflux transmembrane transporter activity
EXW59_RS27175	COG1136	(ABC) transporter
EXW59_RS27180	COG5002	protein histidine kinase activity
EXW59_RS27185	COG0745	RESPONSE REGULATOR receiver
EXW59_RS27190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW59_RS27195	COG3290	protein histidine kinase activity
EXW59_RS27205	COG2868	ribosomal protein
EXW59_RS27215	COG1530	ribonuclease E activity
EXW59_RS27220	COG1994	Peptidase M50
EXW59_RS27225	COG0739	heme binding
EXW59_RS27230	COG2894	cell division
EXW59_RS27235	COG0850	regulation of cytokinetic process
EXW59_RS27250	COG1077	Cell shape determining protein MreB Mrl
EXW59_RS27255	COG2003	Belongs to the UPF0758 family
EXW59_RS27260	COG0424	maF-like protein
EXW59_RS27270	COG0285	dihydrofolate synthase activity
EXW59_RS27285	COG1388	LysM domain
EXW59_RS27290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW59_RS27295	COG0113	porphobilinogen synthase activity
EXW59_RS27300	COG1587	Uroporphyrinogen-III synthase
EXW59_RS27305	COG0181	hydroxymethylbilane synthase activity
EXW59_RS27310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW59_RS27315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW59_RS27320	COG1846	Transcriptional regulator
EXW59_RS27325	COG1764	response to oxidative stress
EXW59_RS27330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW59_RS27340	COG0470	DNA polymerase III
EXW59_RS27340	COG1067	ATP-dependent peptidase activity
EXW59_RS27350	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW59_RS27415	COG0582	viral genome integration into host DNA
EXW59_RS27465	COG0622	Phosphoesterase
EXW59_RS27475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW59_RS27480	COG5401	PFAM Sporulation and spore germination
EXW59_RS27490	COG2197	response regulator
EXW59_RS27495	COG2233	PERMEase
EXW59_RS27500	COG0402	S-adenosylhomocysteine deaminase activity
EXW59_RS27505	COG1983	PspC domain protein
EXW59_RS27510	COG1396	sequence-specific DNA binding
EXW59_RS27515	COG0697	spore germination
EXW59_RS27525	COG1959	2 iron, 2 sulfur cluster binding
EXW59_RS27530	COG1668	transmembrane transport
EXW59_RS27535	COG4152	abc transporter atp-binding protein
EXW59_RS27540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW59_RS27545	COG1360	Flagellar Motor Protein
EXW59_RS27550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW59_RS27555	COG1876	peptidase activity
EXW59_RS27560	COG0824	Thioesterase
EXW59_RS27565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW59_RS27570	COG1053	succinate dehydrogenase
EXW59_RS27575	COG2009	succinate dehydrogenase
EXW59_RS27580	COG1719	4-vinyl reductase, 4VR
EXW59_RS27585	COG0322	excinuclease ABC activity
EXW59_RS27590	COG3118	belongs to the thioredoxin family
EXW59_RS27595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW59_RS27600	COG2086	electron transfer activity
EXW59_RS27605	COG1024	Enoyl-CoA hydratase
EXW59_RS27610	COG1309	transcriptional regulator
EXW59_RS27615	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS27640	COG2318	DinB family
EXW59_RS27665	COG1131	(ABC) transporter
EXW59_RS27670	COG2205	protein histidine kinase activity
EXW59_RS27675	COG0745	RESPONSE REGULATOR receiver
EXW59_RS27685	COG4895	conserved protein (DUF2196)
EXW59_RS27690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW59_RS27700	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_RS27705	COG4509	Sortase family
EXW59_RS27710	COG1120	ATPase activity
EXW59_RS27725	COG5386	Cell surface protein
EXW59_RS27735	COG5386	Cell surface protein
EXW59_RS27740	COG1114	Component of the transport system for branched-chain amino acids
EXW59_RS27750	COG1193	negative regulation of DNA recombination
EXW59_RS27755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW59_RS27755	COG1796	DNA polymerase
EXW59_RS27760	COG1286	toxin biosynthetic process
EXW59_RS27765	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW59_RS27770	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW59_RS27805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW59_RS27810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW59_RS27820	COG1418	mRNA catabolic process
EXW59_RS27850	COG2814	Major facilitator Superfamily
EXW59_RS27855	COG1566	PFAM secretion protein HlyD family protein
EXW59_RS27860	COG1309	transcriptional regulator
EXW59_RS27865	COG1363	Peptidase, m42
EXW59_RS27875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW59_RS27890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW59_RS27900	COG1484	DNA-dependent DNA replication
EXW59_RS27905	COG3611	Membrane attachment protein
EXW59_RS27910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW59_RS27915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW59_RS27920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW59_RS27925	COG0237	dephospho-CoA kinase activity
EXW59_RS27930	COG1971	Probably functions as a manganese efflux pump
EXW59_RS27940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_RS27940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_RS27945	COG5002	protein histidine kinase activity
EXW59_RS27950	COG0745	RESPONSE REGULATOR receiver
EXW59_RS27965	COG0039	L-malate dehydrogenase activity
EXW59_RS27970	COG0538	isocitrate dehydrogenase activity
EXW59_RS27975	COG0372	Belongs to the citrate synthase family
EXW59_RS27985	COG0628	permease
EXW59_RS27990	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW59_RS28000	COG0205	6-phosphofructokinase activity
EXW59_RS28010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW59_RS28015	COG1725	Transcriptional regulator
EXW59_RS28020	COG0281	malic enzyme
EXW59_RS28025	COG0587	DNA-directed DNA polymerase activity
EXW59_RS28040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW59_RS28055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_RS28065	COG4109	DRTGG domain
EXW59_RS28075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW59_RS28080	COG0006	proline dipeptidase activity
EXW59_RS28105	COG0662	Cupin 2, conserved barrel domain protein
EXW59_RS28115	COG1476	TRANSCRIPTIONal
EXW59_RS28130	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_RS28135	COG0589	response to stress
EXW59_RS28150	COG0165	Argininosuccinate lyase
EXW59_RS28155	COG0137	argininosuccinate synthase activity
EXW59_RS28170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS28190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW59_RS28195	COG0827	DNA restriction-modification system
EXW59_RS28200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW59_RS28205	COG3874	Sporulation protein YtfJ
EXW59_RS28220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW59_RS28230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_RS28245	COG1104	cysteine desulfurase activity
EXW59_RS28250	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW59_RS28260	COG1309	transcriptional regulator
EXW59_RS28265	COG1956	GAF domain-containing protein
EXW59_RS28270	COG0626	cystathionine gamma-synthase activity
EXW59_RS28275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW59_RS28315	COG1595	DNA-templated transcription, initiation
EXW59_RS28325	COG0110	maltose O-acetyltransferase activity
EXW59_RS28330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_RS28335	COG0454	-acetyltransferase
EXW59_RS28340	COG0517	IMP dehydrogenase activity
EXW59_RS28345	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW59_RS28360	COG0745	RESPONSE REGULATOR receiver
EXW59_RS28370	COG0666	response to abiotic stimulus
EXW59_RS28380	COG1970	mechanosensitive ion channel activity
EXW59_RS28405	COG1609	Transcriptional regulator
EXW59_RS28420	COG4851	CamS sex pheromone cAM373 precursor
EXW59_RS28425	COG3118	belongs to the thioredoxin family
EXW59_RS28435	COG2309	aminopeptidase activity
EXW59_RS28455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS28460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW59_RS28470	COG1674	ftsk spoiiie
EXW59_RS28485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_RS28490	COG4848	Belongs to the UPF0354 family
EXW59_RS28495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS28500	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW59_RS28505	COG1363	Peptidase, m42
EXW59_RS28515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS28520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW59_RS28530	COG0510	thiamine kinase activity
EXW59_RS28535	COG1523	belongs to the glycosyl hydrolase 13 family
EXW59_RS28545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_RS28550	COG1349	DNA-binding transcription factor activity
EXW59_RS28555	COG1187	pseudouridine synthase activity
EXW59_RS28560	COG2244	polysaccharide biosynthetic process
EXW59_RS28565	COG2081	HI0933 family
EXW59_RS28570	COG2814	Major facilitator Superfamily
EXW59_RS28580	COG3832	glyoxalase III activity
EXW59_RS28600	COG1329	Transcriptional regulator
EXW59_RS28625	COG0314	molybdopterin synthase activity
EXW59_RS28630	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW59_RS28635	COG0303	'Molybdopterin
EXW59_RS28640	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW59_RS28645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_RS28650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW59_RS28670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_RS28680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW59_RS28720	COG0495	leucyl-tRNA aminoacylation
EXW59_RS28725	COG2814	Major facilitator Superfamily
EXW59_RS28730	COG0475	glutathione-regulated potassium exporter activity
EXW59_RS28735	COG0490	domain, Protein
EXW59_RS28740	COG0582	viral genome integration into host DNA
EXW59_RS28750	COG1136	(ABC) transporter
EXW59_RS28770	COG1242	4 iron, 4 sulfur cluster binding
EXW59_RS28775	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW59_RS28790	COG2267	carboxylic ester hydrolase activity
EXW59_RS28795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW59_RS28800	COG0671	phosphoesterase, PA-phosphatase related
EXW59_RS28805	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS28810	COG0746	molybdenum cofactor guanylyltransferase activity
EXW59_RS28830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW59_RS28835	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW59_RS28875	COG5002	protein histidine kinase activity
EXW59_RS28880	COG3852	Histidine kinase
EXW59_RS28885	COG0753	catalase activity
EXW59_RS28890	COG2267	carboxylic ester hydrolase activity
EXW59_RS28895	COG1368	sulfuric ester hydrolase activity
EXW59_RS28905	COG4895	conserved protein (DUF2196)
EXW59_RS28920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_RS28925	COG1116	anion transmembrane transporter activity
EXW59_RS28930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_RS28950	COG0494	nUDIX hydrolase
EXW59_RS28985	COG2076	Multidrug Resistance protein
EXW59_RS28995	COG0789	Transcriptional regulator
EXW59_RS29000	COG1854	S-ribosylhomocysteine lyase activity
EXW59_RS29010	COG0288	reversible hydration of carbon dioxide
EXW59_RS29015	COG1271	oxidase subunit
EXW59_RS29020	COG1294	oxidase, subunit
EXW59_RS29045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS29070	COG1842	Phage shock protein A
EXW59_RS29095	COG3859	Proton-coupled thiamine transporter YuaJ
EXW59_RS29100	COG5002	protein histidine kinase activity
EXW59_RS29105	COG0745	RESPONSE REGULATOR receiver
EXW59_RS29130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW59_RS29135	COG1597	lipid kinase activity
EXW59_RS29175	COG5002	protein histidine kinase activity
EXW59_RS29185	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS29200	COG0577	efflux transmembrane transporter activity
EXW59_RS29205	COG1136	(ABC) transporter
EXW59_RS29210	COG3708	Transcriptional regulator
EXW59_RS29210	COG2207	Transcriptional regulator
EXW59_RS29220	COG1131	(ABC) transporter
EXW59_RS29225	COG5658	integral membrane protein
EXW59_RS29230	COG0640	Transcriptional regulator
EXW59_RS29235	COG0745	RESPONSE REGULATOR receiver
EXW59_RS29240	COG2205	protein histidine kinase activity
EXW59_RS29245	COG0577	efflux transmembrane transporter activity
EXW59_RS29250	COG0577	efflux transmembrane transporter activity
EXW59_RS29255	COG1136	(ABC) transporter
EXW59_RS29260	COG0577	efflux transmembrane transporter activity
EXW59_RS29275	COG2188	Transcriptional regulator
EXW59_RS29295	COG3964	amidohydrolase
EXW59_RS29315	COG4948	Mandelate Racemase Muconate Lactonizing
EXW59_RS29320	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_RS29325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW59_RS29330	COG0596	Alpha beta hydrolase
EXW59_RS29335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW59_RS29340	COG1169	isochorismate synthase
EXW59_RS29345	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW59_RS29350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW59_RS29355	COG1278	Cold shock
EXW59_RS29370	COG0789	Transcriptional regulator
EXW59_RS29380	COG0058	SHG alpha-glucan phosphorylase activity
EXW59_RS29390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW59_RS29395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW59_RS29400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW59_RS29410	COG1404	Belongs to the peptidase S8 family
EXW59_RS29545	COG1285	pathogenesis
EXW59_RS29550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW59_RS29560	COG0166	Belongs to the GPI family
EXW59_RS29565	COG2155	Conserved Protein
EXW59_RS29570	COG1098	S1 RNA binding domain
EXW59_RS29575	COG0436	Aminotransferase
EXW59_RS29580	COG1522	sequence-specific DNA binding
EXW59_RS29585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW59_RS29590	COG2267	carboxylic ester hydrolase activity
EXW59_RS29600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW59_RS29620	COG5018	Exonuclease
EXW59_RS29625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_RS29645	COG2050	protein possibly involved in aromatic compounds catabolism
EXW59_RS29655	COG1268	BioY protein
EXW59_RS29660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_RS29665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW59_RS29675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW59_RS29680	COG3584	3D domain protein
EXW59_RS29695	COG1252	NADH dehydrogenase
EXW59_RS29700	COG0492	ferredoxin-NADP+ reductase activity
EXW59_RS29705	COG3708	Transcriptional regulator
EXW59_RS29720	COG1683	Conserved Protein
EXW59_RS29740	COG0316	Belongs to the HesB IscA family
EXW59_RS29745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW59_RS29750	COG4844	belongs to the
EXW59_RS29755	COG1252	NADH dehydrogenase
EXW59_RS29765	COG0390	transport system, permease component
EXW59_RS29770	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW59_RS29810	COG4837	Protein of unknown function (DUF1462)
EXW59_RS29815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW59_RS29825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_RS29830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW59_RS29845	COG1136	(ABC) transporter
EXW59_RS29845	COG0577	efflux transmembrane transporter activity
EXW59_RS29850	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_RS29860	COG0647	UMP catabolic process
EXW59_RS29870	COG2445	Protein of unknown function DUF86
EXW59_RS29875	COG1494	fructose-1,6-bisphosphatase
EXW59_RS29890	COG4470	Protein conserved in bacteria
EXW59_RS29900	COG0789	Transcriptional regulator
EXW59_RS29905	COG4377	Putative membrane peptidase family (DUF2324)
EXW59_RS29925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW59_RS29930	COG0739	heme binding
EXW59_RS29940	COG3377	Domain of unknown function (DUF1805)
EXW59_RS29945	COG0737	Belongs to the 5'-nucleotidase family
EXW59_RS29950	COG0719	Fe-S assembly protein
EXW59_RS29955	COG0822	iron-sulfur transferase activity
EXW59_RS29960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW59_RS29965	COG0719	Fe-S assembly protein
EXW59_RS29970	COG0396	ATPase activity
EXW59_RS29975	COG1464	Belongs to the NlpA lipoprotein family
EXW59_RS29980	COG1464	Belongs to the NlpA lipoprotein family
EXW59_RS29985	COG2011	ABC-type metal ion transport system permease component
EXW59_RS30000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_RS30005	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW59_RS30010	COG0509	glycine decarboxylation via glycine cleavage system
EXW59_RS30015	COG1393	Belongs to the ArsC family
EXW59_RS30050	COG1309	transcriptional regulator
EXW59_RS30055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_RS30060	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS30065	COG0183	Belongs to the thiolase family
EXW59_RS30070	COG1024	Enoyl-CoA hydratase
EXW59_RS30070	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW59_RS30080	COG1686	Belongs to the peptidase S11 family
EXW59_RS30085	COG0506	proline dehydrogenase activity
EXW59_RS30095	COG0011	TIGRFAM Protein of
EXW59_RS30100	COG0840	transmembrane signaling receptor activity
EXW59_RS30115	COG2814	Major facilitator Superfamily
EXW59_RS30120	COG0531	amino acid
EXW59_RS30145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_RS30200	COG0586	Pfam SNARE associated Golgi protein
EXW59_RS30210	COG1376	ErfK ybiS ycfS ynhG family protein
EXW59_RS30215	COG0745	RESPONSE REGULATOR receiver
EXW59_RS30220	COG5002	protein histidine kinase activity
EXW59_RS30230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_RS30240	COG0840	transmembrane signaling receptor activity
EXW59_RS30245	COG0840	transmembrane signaling receptor activity
EXW59_RS30250	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW59_RS30255	COG3227	Zinc metalloprotease (Elastase)
EXW59_RS30260	COG1741	Belongs to the pirin family
EXW59_RS30280	COG0475	glutathione-regulated potassium exporter activity
EXW59_RS30285	COG0490	domain, Protein
EXW59_RS30290	COG1115	amino acid carrier protein
EXW59_RS30295	COG0783	Belongs to the Dps family
EXW59_RS30305	COG2318	DinB family
EXW59_RS30310	COG1611	Belongs to the LOG family
EXW59_RS30320	COG1528	Iron-storage protein
EXW59_RS30325	COG2311	Membrane
EXW59_RS30330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS30335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS30340	COG1115	amino acid carrier protein
EXW59_RS30345	COG1115	amino acid carrier protein
EXW59_RS30350	COG2910	NAD(P)H-binding
EXW59_RS30375	COG0656	L-ascorbic acid biosynthetic process
EXW59_RS30380	COG2814	Major facilitator Superfamily
EXW59_RS30385	COG1733	regulation of RNA biosynthetic process
EXW59_RS30395	COG1252	NADH dehydrogenase
EXW59_RS30415	COG0840	transmembrane signaling receptor activity
EXW59_RS30415	COG3290	protein histidine kinase activity
EXW59_RS30425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW59_RS30440	COG3655	Transcriptional regulator
EXW59_RS30455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_RS30465	COG1733	regulation of RNA biosynthetic process
EXW59_RS30470	COG0778	Nitroreductase
EXW59_RS30475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_RS30480	COG4224	UPF0291 protein
EXW59_RS30485	COG1522	sequence-specific DNA binding
EXW59_RS30490	COG0288	reversible hydration of carbon dioxide
EXW59_RS30495	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW59_RS30500	COG2233	PERMEase
EXW59_RS30545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW59_RS30550	COG0557	exoribonuclease II activity
EXW59_RS30555	COG1647	Serine aminopeptidase, S33
EXW59_RS30560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW59_RS30565	COG1346	cytolysis
EXW59_RS30580	COG0148	phosphopyruvate hydratase activity
EXW59_RS30590	COG0149	triose-phosphate isomerase activity
EXW59_RS30595	COG0126	phosphoglycerate kinase activity
EXW59_RS30600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW59_RS30615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW59_RS30640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_RS30655	COG2323	membrane
EXW59_RS30665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_RS30670	COG1481	regulation of sporulation
EXW59_RS30675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW59_RS30680	COG1660	Displays ATPase and GTPase activities
EXW59_RS30685	COG1051	belongs to the nudix hydrolase family
EXW59_RS30695	COG0492	ferredoxin-NADP+ reductase activity
EXW59_RS30700	COG0457	Tetratricopeptide repeat
EXW59_RS30705	COG0110	maltose O-acetyltransferase activity
EXW59_RS30710	COG0546	phosphoglycolate phosphatase activity
EXW59_RS30715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW59_RS30720	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW59_RS30725	COG1950	PFAM Membrane protein of
EXW59_RS30735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW59_RS30755	COG0789	Transcriptional regulator
EXW59_RS30790	COG0583	DNA-binding transcription factor activity
EXW59_RS30795	COG0789	Transcriptional regulator
EXW59_RS30800	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW59_RS30805	COG0488	(ABC) transporter
EXW59_RS30815	COG1132	(ABC) transporter
EXW59_RS30820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_RS30825	COG0793	Belongs to the peptidase S41A family
EXW59_RS30825	COG3409	Peptidoglycan-binding domain 1 protein
EXW59_RS30830	COG2177	Part of the ABC transporter FtsEX involved in
EXW59_RS30835	COG2884	Cell division ATP-binding protein ftsE
EXW59_RS30860	COG1131	(ABC) transporter
EXW59_RS30895	COG1278	Cold shock
EXW59_RS30900	COG1040	competence protein
EXW59_RS30905	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW59_RS30910	COG0791	NLP P60 protein
EXW59_RS30910	COG1388	LysM domain
EXW59_RS30915	COG1733	regulation of RNA biosynthetic process
EXW59_RS30920	COG1307	EDD domain protein, DegV family
EXW59_RS30925	COG1739	Uncharacterized protein family UPF0029
EXW59_RS30930	COG1316	TRANSCRIPTIONal
EXW59_RS30935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW59_RS30940	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_RS30945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW59_RS30955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW59_RS30955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW59_RS30975	COG1486	melibiose metabolic process
EXW59_RS30980	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_RS30985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_RS31005	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_RS31015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_RS31020	COG1301	dicarboxylic acid transport
EXW59_RS31035	COG1511	domain protein
EXW59_RS31040	COG0583	DNA-binding transcription factor activity
EXW59_RS31045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW59_RS31055	COG1271	oxidase subunit
EXW59_RS31060	COG1294	oxidase, subunit
EXW59_RS31065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_RS31070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW59_RS31075	COG1620	l-lactate permease
EXW59_RS31085	COG2389	metal-binding protein
EXW59_RS31095	COG1368	sulfuric ester hydrolase activity
EXW59_RS31105	COG0791	NLP P60 protein
EXW59_RS31105	COG1388	LysM domain
EXW59_RS31110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_RS31120	COG1215	transferase activity, transferring glycosyl groups
EXW59_RS31125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW59_RS31130	COG3584	3D domain protein
EXW59_RS31130	COG1388	LysM domain
EXW59_RS31155	COG4715	Zinc finger, swim domain protein
EXW59_RS31160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_RS31200	COG0577	efflux transmembrane transporter activity
EXW59_RS31205	COG1136	(ABC) transporter
EXW59_RS31240	COG5002	protein histidine kinase activity
EXW59_RS31240	COG3850	Histidine kinase
EXW59_RS31245	COG0745	RESPONSE REGULATOR receiver
EXW59_RS31255	COG1316	TRANSCRIPTIONal
EXW59_RS31260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW59_RS31265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_RS31270	COG1215	transferase activity, transferring glycosyl groups
EXW59_RS31275	COG0438	transferase activity, transferring glycosyl groups
EXW59_RS31295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_RS31300	COG4464	protein tyrosine phosphatase activity
EXW59_RS31305	COG0489	protein tyrosine kinase activity
EXW59_RS31310	COG3944	biosynthesis protein
EXW59_RS31315	COG0489	protein tyrosine kinase activity
EXW59_RS31330	COG1609	Transcriptional regulator
EXW59_RS31340	COG0739	heme binding
EXW59_RS31355	COG3279	Response regulator of the LytR AlgR family
EXW59_RS31360	COG2385	sporulation resulting in formation of a cellular spore
EXW59_RS31375	COG4836	Membrane
EXW59_RS31380	COG1007	ATP synthesis coupled electron transport
EXW59_RS31385	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_RS31390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW59_RS31395	COG0713	ATP synthesis coupled electron transport
EXW59_RS31400	COG0839	Belongs to the complex I subunit 6 family
EXW59_RS31410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW59_RS31415	COG0649	NAD binding
EXW59_RS31420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_RS31425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_RS31430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_RS31435	COG3300	MHYT domain
EXW59_RS31435	COG5001	Diguanylate cyclase
EXW59_RS31450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW59_RS31455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW59_RS31460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW59_RS31465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW59_RS31470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW59_RS31475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW59_RS31485	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW59_RS31510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW59_RS31520	COG0698	ribose 5-phosphate isomerase
EXW59_RS31530	COG2190	(PTS) system
EXW59_RS31535	COG2259	Doxx family
EXW59_RS31540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW59_RS31550	COG1971	Probably functions as a manganese efflux pump
EXW59_RS31555	COG0009	L-threonylcarbamoyladenylate synthase
EXW59_RS31570	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW59_RS31575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW59_RS31580	COG1435	thymidine kinase activity
EXW59_RS31590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW59_RS31595	COG1494	fructose-1,6-bisphosphatase
EXW59_RS31615	COG4821	SIS domain
EXW59_RS31620	COG0504	CTP synthase activity
EXW59_RS31625	COG3343	RNA polymerase activity
EXW59_RS31635	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS31640	COG1960	acyl-CoA dehydrogenase activity
EXW59_RS31645	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW59_RS31650	COG0183	Belongs to the thiolase family
EXW59_RS31655	COG2181	nitrate reductase activity
EXW59_RS31655	COG0247	lactate metabolic process
EXW59_RS31660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_RS31665	COG4294	response to UV
EXW59_RS31670	COG5001	Diguanylate cyclase
EXW59_RS31670	COG3300	MHYT domain
EXW59_RS31685	COG3227	Zinc metalloprotease (Elastase)
EXW59_RS31690	COG2197	response regulator
EXW59_RS31695	COG4585	Histidine kinase
EXW59_RS31700	COG0842	Transport permease protein
EXW59_RS31705	COG1131	(ABC) transporter
EXW59_RS31710	COG0024	Methionine aminopeptidase
EXW59_RS31720	COG2234	aminopeptidase activity
EXW59_RS31735	COG4506	Protein conserved in bacteria
EXW59_RS31740	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_RS31755	COG0010	Belongs to the arginase family
EXW59_RS31760	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW59_RS31765	COG2814	Major facilitator Superfamily
EXW59_RS31770	COG0789	Transcriptional regulator
EXW59_RS31775	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_RS31780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_RS31790	COG1994	Peptidase M50
EXW59_RS31800	COG1078	dGTPase activity
EXW59_RS31805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_RS31810	COG1120	ATPase activity
EXW59_RS31815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS31820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_RS31825	COG4844	belongs to the
EXW59_RS31840	COG0280	phosphate acetyltransferase
EXW59_RS31845	COG3253	May function as heme-dependent peroxidase
EXW59_RS31855	COG3773	Cell wall hydrolase
EXW59_RS31865	COG2363	Small membrane protein
EXW59_RS31880	COG2233	PERMEase
EXW59_RS31885	COG0561	phosphatase activity
EXW59_RS31890	COG2814	Major facilitator Superfamily
EXW59_RS31895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW59_RS31900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_RS31905	COG1131	(ABC) transporter
EXW59_RS31910	COG2755	lipolytic protein G-D-S-L family
EXW59_RS31915	COG1609	Transcriptional regulator
EXW59_RS31925	COG0460	homoserine dehydrogenase
EXW59_RS31930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW59_RS31935	COG2873	o-acetylhomoserine
EXW59_RS31950	COG2197	response regulator
EXW59_RS31955	COG2203	Gaf domain
EXW59_RS31955	COG4585	Histidine kinase
EXW59_RS31960	COG0351	phosphomethylpyrimidine kinase
EXW59_RS31965	COG3706	GGDEF domain
EXW59_RS31970	COG2879	small protein
EXW59_RS31975	COG1966	Carbon starvation protein
EXW59_RS31980	COG3279	Response regulator of the LytR AlgR family
EXW59_RS31985	COG0477	Major facilitator Superfamily
EXW59_RS32010	COG0840	transmembrane signaling receptor activity
EXW59_RS32020	COG1607	acyl-coa hydrolase
EXW59_RS32025	COG1216	Glycosyl transferase, family 2
EXW59_RS32040	COG1216	Glycosyl transferase, family 2
EXW59_RS32050	COG0488	(ABC) transporter
EXW59_RS32055	COG1309	transcriptional regulator
EXW59_RS32060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW59_RS32065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_RS32065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_RS32070	COG0628	permease
EXW59_RS32080	COG1380	Effector of murein hydrolase LrgA
EXW59_RS32085	COG3279	Response regulator of the LytR AlgR family
EXW59_RS32090	COG3275	phosphorelay sensor kinase activity
EXW59_RS32095	COG2814	Major facilitator Superfamily
EXW59_RS32100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW59_RS32105	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW59_RS32110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_RS32160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW59_RS32165	COG1272	protein, Hemolysin III
EXW59_RS32190	COG1164	Oligoendopeptidase f
EXW59_RS32205	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW59_RS32215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_RS32220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW59_RS32225	COG4853	Protein conserved in bacteria
EXW59_RS32235	COG5002	protein histidine kinase activity
EXW59_RS32240	COG0745	RESPONSE REGULATOR receiver
EXW59_RS32270	COG0305	Participates in initiation and elongation during chromosome replication
EXW59_RS32275	COG0359	binds to the 23S rRNA
EXW59_RS32280	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW59_RS32285	COG4241	membrane
EXW59_RS32295	COG0629	single-stranded DNA binding
EXW59_RS32300	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW59_RS32305	COG0012	GTP binding
EXW59_RS32310	COG4481	Protein conserved in bacteria
EXW59_RS32315	COG0668	transmembrane transport
EXW59_RS32325	COG1475	DNA binding
EXW59_RS32330	COG1192	Involved in chromosome partitioning
EXW59_RS32335	COG1475	DNA binding
EXW59_RS32340	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW59_RS32345	COG0445	tRNA wobble uridine modification
EXW59_RS32350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW59_RS32355	COG1847	R3H domain protein
EXW59_RS32360	COG0706	membrane insertase activity
EXW59_RS32365	COG0594	ribonuclease P activity
EXW59_RS32370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW59_RS32825	COG2076	Multidrug Resistance protein