locus-tag	class	description
EXW46_RS00015	COG1846	Transcriptional regulator
EXW46_RS00035	COG1968	undecaprenyl-diphosphatase activity
EXW46_RS00040	COG0534	Mate efflux family protein
EXW46_RS00075	COG0716	FMN binding
EXW46_RS00095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW46_RS00100	COG1696	Membrane protein involved in D-alanine export
EXW46_RS00105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_RS00110	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW46_RS00115	COG2070	2-Nitropropane dioxygenase
EXW46_RS00120	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_RS00130	COG1335	isochorismatase
EXW46_RS00140	COG1522	sequence-specific DNA binding
EXW46_RS00150	COG1266	CAAX protease self-immunity
EXW46_RS00155	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_RS00160	COG1131	(ABC) transporter
EXW46_RS00170	COG1131	(ABC) transporter
EXW46_RS00175	COG1725	Transcriptional regulator
EXW46_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS00190	COG2204	response regulator
EXW46_RS00205	COG0531	amino acid
EXW46_RS00210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW46_RS00225	COG1780	Probably involved in ribonucleotide reductase function
EXW46_RS00240	COG0456	acetyltransferase
EXW46_RS00255	COG4873	Protein conserved in bacteria
EXW46_RS00260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW46_RS00270	COG0720	synthase
EXW46_RS00275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW46_RS00280	COG5002	protein histidine kinase activity
EXW46_RS00285	COG2318	DinB family
EXW46_RS00295	COG1846	Transcriptional regulator
EXW46_RS00300	COG3852	Histidine kinase
EXW46_RS00310	COG2861	carbohydrate metabolic process
EXW46_RS00320	COG0235	Class ii aldolase
EXW46_RS00330	COG1349	DNA-binding transcription factor activity
EXW46_RS00340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW46_RS00345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW46_RS00355	COG3842	ATPase activity
EXW46_RS00360	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW46_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_RS00385	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW46_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS00410	COG2030	dehydratase
EXW46_RS00420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_RS00425	COG0861	Integral membrane protein TerC family
EXW46_RS00430	COG2116	formate transmembrane transporter activity
EXW46_RS00440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW46_RS00445	COG1556	Lactate utilization protein
EXW46_RS00450	COG1139	Iron-sulfur cluster binding protein
EXW46_RS00455	COG0247	lactate metabolic process
EXW46_RS00460	COG2186	Transcriptional regulator
EXW46_RS00465	COG3850	Histidine kinase
EXW46_RS00465	COG5002	protein histidine kinase activity
EXW46_RS00470	COG0745	RESPONSE REGULATOR receiver
EXW46_RS00480	COG3835	regulator
EXW46_RS00485	COG0277	FAD linked oxidase domain protein
EXW46_RS00490	COG0247	lactate metabolic process
EXW46_RS00495	COG2340	Cysteine-rich secretory protein family
EXW46_RS00505	COG0564	pseudouridine synthase activity
EXW46_RS00515	COG2409	Drug exporters of the RND superfamily
EXW46_RS00525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW46_RS00530	COG1177	transmembrane transport
EXW46_RS00535	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW46_RS00545	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS00580	COG0681	Belongs to the peptidase S26 family
EXW46_RS00585	COG1686	Belongs to the peptidase S11 family
EXW46_RS00630	COG1476	TRANSCRIPTIONal
EXW46_RS00635	COG0567	Dehydrogenase, E1 component
EXW46_RS00640	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_RS00660	COG2226	methyltransferase
EXW46_RS00715	COG5634	Uncharacterized conserved protein (DUF2278)
EXW46_RS00720	COG1620	l-lactate permease
EXW46_RS00730	COG0159	tryptophan synthase activity
EXW46_RS00735	COG0133	tryptophan synthase activity
EXW46_RS00740	COG0135	phosphoribosylanthranilate isomerase activity
EXW46_RS00745	COG0134	indole-3-glycerol-phosphate synthase activity
EXW46_RS00750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW46_RS00755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW46_RS00755	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW46_RS00765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_RS00770	COG5492	domain, Protein
EXW46_RS00795	COG2382	esterase
EXW46_RS00800	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW46_RS00805	COG2153	protein acetylation
EXW46_RS00850	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW46_RS00865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW46_RS00885	COG0463	Glycosyl transferase, family 2
EXW46_RS00885	COG0457	Tetratricopeptide repeat
EXW46_RS00905	COG1216	Glycosyl transferase, family 2
EXW46_RS00910	COG0772	Belongs to the SEDS family
EXW46_RS00915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW46_RS00925	COG0564	pseudouridine synthase activity
EXW46_RS00935	COG2357	RelA SpoT domain protein
EXW46_RS00945	COG4116	CYTH
EXW46_RS00950	COG2346	COG2346, Truncated hemoglobins
EXW46_RS00965	COG1164	Oligoendopeptidase f
EXW46_RS00975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_RS00980	COG4862	establishment of competence for transformation
EXW46_RS00985	COG0861	Integral membrane protein TerC family
EXW46_RS01000	COG4166	transmembrane transport
EXW46_RS01005	COG0534	Mate efflux family protein
EXW46_RS01010	COG4608	Belongs to the ABC transporter superfamily
EXW46_RS01015	COG0444	Belongs to the ABC transporter superfamily
EXW46_RS01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_RS01025	COG0601	transmembrane transport
EXW46_RS01030	COG4166	transmembrane transport
EXW46_RS01040	COG0180	Tryptophanyl-tRNA synthetase
EXW46_RS01050	COG5504	Zn-dependent protease
EXW46_RS01055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW46_RS01060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_RS01075	COG2267	carboxylic ester hydrolase activity
EXW46_RS01095	COG0561	phosphatase activity
EXW46_RS01110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS01120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW46_RS01150	COG1329	Transcriptional regulator
EXW46_RS01165	COG2996	Protein conserved in bacteria
EXW46_RS01170	COG1666	GTP binding
EXW46_RS01185	COG0004	ammonium transporteR
EXW46_RS01190	COG0753	catalase activity
EXW46_RS01205	COG0367	asparagine synthase
EXW46_RS01230	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_RS01285	COG1074	ATP-dependent DNA helicase activity
EXW46_RS01290	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW46_RS01300	COG0398	Pfam SNARE associated Golgi protein
EXW46_RS01310	COG4903	ComK protein
EXW46_RS01320	COG1278	Cold shock
EXW46_RS01330	COG2224	Isocitrate lyase
EXW46_RS01335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW46_RS01360	COG0697	spore germination
EXW46_RS01365	COG0501	Belongs to the peptidase M48B family
EXW46_RS01385	COG0745	RESPONSE REGULATOR receiver
EXW46_RS01390	COG2205	protein histidine kinase activity
EXW46_RS01395	COG2207	Transcriptional regulator
EXW46_RS01395	COG3708	Transcriptional regulator
EXW46_RS01400	COG1595	DNA-templated transcription, initiation
EXW46_RS01425	COG1129	ABC transporter
EXW46_RS01430	COG1078	dGTPase activity
EXW46_RS01435	COG1408	metallophosphoesterase
EXW46_RS01480	COG4208	sulfate ABC transporter
EXW46_RS01490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW46_RS01505	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS01515	COG0095	Lipoate-protein ligase
EXW46_RS01520	COG1234	tRNA 3'-trailer cleavage
EXW46_RS01530	COG1609	Transcriptional regulator
EXW46_RS01535	COG2378	regulation of single-species biofilm formation
EXW46_RS01575	COG1511	domain protein
EXW46_RS01575	COG1511	domain protein
EXW46_RS01580	COG1309	transcriptional regulator
EXW46_RS01615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW46_RS01620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW46_RS01625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW46_RS01630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_RS01635	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_RS01640	COG3428	Bacterial PH domain
EXW46_RS01645	COG3402	PFAM membrane-flanked domain
EXW46_RS01675	COG3428	Bacterial PH domain
EXW46_RS01680	COG3402	PFAM membrane-flanked domain
EXW46_RS01700	COG1556	Lactate utilization protein
EXW46_RS01705	COG1139	Iron-sulfur cluster binding protein
EXW46_RS01710	COG0247	lactate metabolic process
EXW46_RS01720	COG4473	ABC transporter
EXW46_RS01725	COG1131	(ABC) transporter
EXW46_RS01730	COG0537	adenosine 5'-monophosphoramidase activity
EXW46_RS01740	COG1846	Transcriptional regulator
EXW46_RS01760	COG3973	AAA domain
EXW46_RS01775	COG1595	DNA-templated transcription, initiation
EXW46_RS01780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW46_RS01785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW46_RS01790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW46_RS01795	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW46_RS01800	COG3620	sequence-specific DNA binding
EXW46_RS01815	COG2267	carboxylic ester hydrolase activity
EXW46_RS01825	COG0457	Tetratricopeptide repeat
EXW46_RS01830	COG0346	lactoylglutathione lyase activity
EXW46_RS01835	COG0346	lactoylglutathione lyase activity
EXW46_RS01845	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW46_RS01850	COG4717	serine-type aminopeptidase activity
EXW46_RS01855	COG0420	3'-5' exonuclease activity
EXW46_RS01885	COG2197	response regulator
EXW46_RS01890	COG4585	Histidine kinase
EXW46_RS01930	COG0784	Response regulator, receiver
EXW46_RS01930	COG2205	protein histidine kinase activity
EXW46_RS01935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW46_RS01940	COG2208	phosphoserine phosphatase activity
EXW46_RS01950	COG1191	sigma factor activity
EXW46_RS01955	COG2172	sigma factor antagonist activity
EXW46_RS01975	COG3237	CsbD-like
EXW46_RS02000	COG1278	Cold shock
EXW46_RS02015	COG0076	glutamate decarboxylase activity
EXW46_RS02050	COG1335	isochorismatase
EXW46_RS02070	COG5444	nuclease activity
EXW46_RS02145	COG2376	Dihydroxyacetone kinase
EXW46_RS02155	COG2376	Dihydroxyacetone kinase
EXW46_RS02175	COG1183	phosphatidylcholine synthase activity
EXW46_RS02190	COG0640	Transcriptional regulator
EXW46_RS02195	COG2814	Major facilitator Superfamily
EXW46_RS02200	COG2732	(Barnase) inhibitor
EXW46_RS02275	COG0477	Major facilitator Superfamily
EXW46_RS02310	COG0305	Participates in initiation and elongation during chromosome replication
EXW46_RS02365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXW46_RS02390	COG3181	Tripartite tricarboxylate transporter family receptor
EXW46_RS02395	COG4565	transcriptional regulatory protein
EXW46_RS02400	COG3290	protein histidine kinase activity
EXW46_RS02405	COG0477	Major facilitator Superfamily
EXW46_RS02480	COG5444	nuclease activity
EXW46_RS02495	COG4608	Belongs to the ABC transporter superfamily
EXW46_RS02500	COG0444	Belongs to the ABC transporter superfamily
EXW46_RS02505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_RS02510	COG0601	transmembrane transport
EXW46_RS02545	COG0579	oxidoreductase
EXW46_RS02565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW46_RS02570	COG1113	amino acid transport
EXW46_RS02590	COG1363	Peptidase, m42
EXW46_RS02605	COG1024	Enoyl-CoA hydratase
EXW46_RS02620	COG1696	Membrane protein involved in D-alanine export
EXW46_RS02635	COG4196	transglutaminase domain protein
EXW46_RS02640	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS02650	COG2244	polysaccharide biosynthetic process
EXW46_RS02670	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_RS02680	COG4978	Transcriptional regulator
EXW46_RS02680	COG0789	Transcriptional regulator
EXW46_RS02690	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS02700	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS02705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW46_RS02710	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS02710	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_RS02715	COG0561	phosphatase activity
EXW46_RS02720	COG2094	Belongs to the DNA glycosylase MPG family
EXW46_RS02725	COG1216	Glycosyl transferase, family 2
EXW46_RS02730	COG0463	Glycosyl transferase, family 2
EXW46_RS02735	COG3527	Alpha-acetolactate decarboxylase
EXW46_RS02740	COG0028	Belongs to the TPP enzyme family
EXW46_RS02755	COG3679	Belongs to the UPF0342 family
EXW46_RS02760	COG4399	Belongs to the UPF0754 family
EXW46_RS02770	COG0189	ligase activity
EXW46_RS02785	COG1126	abc transporter atp-binding protein
EXW46_RS02790	COG0765	amino acid transport
EXW46_RS02795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS02800	COG1132	(ABC) transporter
EXW46_RS02805	COG1132	(ABC) transporter
EXW46_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS02815	COG0531	amino acid
EXW46_RS02825	COG0693	protein deglycase activity
EXW46_RS02835	COG2211	Major facilitator Superfamily
EXW46_RS02840	COG4533	DNA binding
EXW46_RS02850	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW46_RS02860	COG1733	regulation of RNA biosynthetic process
EXW46_RS02865	COG2814	Major facilitator Superfamily
EXW46_RS02870	COG1309	transcriptional regulator
EXW46_RS02875	COG2076	Multidrug Resistance protein
EXW46_RS02900	COG1522	sequence-specific DNA binding
EXW46_RS02925	COG2259	Doxx family
EXW46_RS02935	COG1263	PTS System
EXW46_RS02935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_RS02940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW46_RS02945	COG1737	Transcriptional regulator
EXW46_RS02955	COG0475	glutathione-regulated potassium exporter activity
EXW46_RS02960	COG0531	amino acid
EXW46_RS02995	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS03025	COG3546	catalase activity
EXW46_RS03030	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS03045	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW46_RS03055	COG1136	(ABC) transporter
EXW46_RS03060	COG0577	efflux transmembrane transporter activity
EXW46_RS03065	COG1388	LysM domain
EXW46_RS03065	COG3584	3D domain protein
EXW46_RS03090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS03095	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_RS03100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_RS03100	COG3711	transcriptional antiterminator
EXW46_RS03110	COG2814	Major facilitator Superfamily
EXW46_RS03120	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW46_RS03125	COG0604	alcohol dehydrogenase
EXW46_RS03130	COG1316	TRANSCRIPTIONal
EXW46_RS03140	COG0730	response to heat
EXW46_RS03145	COG2210	Belongs to the sulfur carrier protein TusA family
EXW46_RS03150	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_RS03150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_RS03155	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_RS03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS03160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_RS03165	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_RS03165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_RS03170	COG1937	Protein conserved in bacteria
EXW46_RS03205	COG2719	SpoVR family
EXW46_RS03210	COG0778	Nitroreductase
EXW46_RS03245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW46_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS03275	COG2252	PERMEase
EXW46_RS03285	COG1846	Transcriptional regulator
EXW46_RS03290	COG2814	Major facilitator Superfamily
EXW46_RS03295	COG2205	protein histidine kinase activity
EXW46_RS03300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW46_RS03305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW46_RS03335	COG0351	phosphomethylpyrimidine kinase
EXW46_RS03340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_RS03350	COG2104	thiamine diphosphate biosynthetic process
EXW46_RS03355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_RS03360	COG0352	thiamine-phosphate diphosphorylase activity
EXW46_RS03365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_RS03370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_RS03375	COG1116	anion transmembrane transporter activity
EXW46_RS03380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW46_RS03385	COG4991	sh3 domain protein
EXW46_RS03385	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS03385	COG3103	Sh3 type 3 domain protein
EXW46_RS03400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW46_RS03520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW46_RS03525	COG0581	inorganic phosphate transmembrane transporter activity
EXW46_RS03530	COG0573	inorganic phosphate transmembrane transporter activity
EXW46_RS03535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW46_RS03545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW46_RS03550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW46_RS03560	COG0531	amino acid
EXW46_RS03565	COG0697	spore germination
EXW46_RS03570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_RS03585	COG4990	cell redox homeostasis
EXW46_RS03595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW46_RS03600	COG1845	cytochrome c oxidase, subunit III
EXW46_RS03610	COG0475	glutathione-regulated potassium exporter activity
EXW46_RS03610	COG0569	domain protein
EXW46_RS03620	COG2153	protein acetylation
EXW46_RS03635	COG2252	PERMEase
EXW46_RS03640	COG1113	amino acid transport
EXW46_RS03655	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS03660	COG3104	oligopeptide transport
EXW46_RS03680	COG1476	TRANSCRIPTIONal
EXW46_RS03685	COG3583	domain protein
EXW46_RS03685	COG3584	3D domain protein
EXW46_RS03690	COG0840	transmembrane signaling receptor activity
EXW46_RS03735	COG1063	alcohol dehydrogenase
EXW46_RS03765	COG1879	ABC-type sugar transport system periplasmic component
EXW46_RS03770	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW46_RS03780	COG1869	D-ribose catabolic process
EXW46_RS03785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW46_RS03790	COG1609	Transcriptional regulator
EXW46_RS03795	COG0477	Major facilitator Superfamily
EXW46_RS03800	COG1846	Transcriptional regulator
EXW46_RS03805	COG2271	Major facilitator Superfamily
EXW46_RS03820	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_RS03835	COG5002	protein histidine kinase activity
EXW46_RS03840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW46_RS03845	COG2378	regulation of single-species biofilm formation
EXW46_RS03875	COG0833	amino acid
EXW46_RS03880	COG0765	amino acid transport
EXW46_RS03885	COG0765	amino acid transport
EXW46_RS03890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS03895	COG1126	abc transporter atp-binding protein
EXW46_RS03900	COG1115	amino acid carrier protein
EXW46_RS03905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW46_RS03920	COG1404	Belongs to the peptidase S8 family
EXW46_RS03930	COG4585	Histidine kinase
EXW46_RS03935	COG0697	spore germination
EXW46_RS03950	COG0366	Alpha amylase catalytic
EXW46_RS03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_RS03955	COG1263	PTS System
EXW46_RS03960	COG2188	Transcriptional regulator
EXW46_RS03965	COG0531	amino acid
EXW46_RS03985	COG0714	Associated with various cellular activities
EXW46_RS03990	COG4548	von Willebrand factor, type A
EXW46_RS04000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_RS04005	COG0156	8-amino-7-oxononanoate synthase activity
EXW46_RS04010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS04025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS04030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS04035	COG3104	oligopeptide transport
EXW46_RS04050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS04055	COG1620	l-lactate permease
EXW46_RS04060	COG1027	Aspartate ammonia-lyase
EXW46_RS04065	COG1253	flavin adenine dinucleotide binding
EXW46_RS04070	COG0346	lactoylglutathione lyase activity
EXW46_RS04075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS04080	COG1316	TRANSCRIPTIONal
EXW46_RS04085	COG2720	vancomycin resistance protein
EXW46_RS04105	COG3227	Zinc metalloprotease (Elastase)
EXW46_RS04120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW46_RS04125	COG2217	Heavy metal translocating P-type atpase
EXW46_RS04130	COG0640	Transcriptional regulator
EXW46_RS04140	COG0531	amino acid
EXW46_RS04155	COG2427	Protein of unknown function (DUF1641)
EXW46_RS04160	COG3383	formate dehydrogenase (NAD+) activity
EXW46_RS04165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW46_RS04170	COG0456	acetyltransferase
EXW46_RS04175	COG0745	RESPONSE REGULATOR receiver
EXW46_RS04180	COG5002	protein histidine kinase activity
EXW46_RS04190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS04195	COG0697	spore germination
EXW46_RS04205	COG0281	malic enzyme
EXW46_RS04210	COG3493	citrate carrier protein
EXW46_RS04215	COG4565	transcriptional regulatory protein
EXW46_RS04220	COG3290	protein histidine kinase activity
EXW46_RS04230	COG4990	cell redox homeostasis
EXW46_RS04240	COG5002	protein histidine kinase activity
EXW46_RS04245	COG0745	RESPONSE REGULATOR receiver
EXW46_RS04250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW46_RS04260	COG0395	ABC-type sugar transport system, permease component
EXW46_RS04265	COG1175	transmembrane transport
EXW46_RS04270	COG3842	ATPase activity
EXW46_RS04275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW46_RS04300	COG2851	Citrate transporter
EXW46_RS04305	COG4565	transcriptional regulatory protein
EXW46_RS04310	COG3290	protein histidine kinase activity
EXW46_RS04320	COG2268	Band 7 protein
EXW46_RS04325	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW46_RS04340	COG2718	Belongs to the UPF0229 family
EXW46_RS04345	COG2766	serine protein kinase
EXW46_RS04350	COG1716	ATPase activity
EXW46_RS04350	COG5001	Diguanylate cyclase
EXW46_RS04355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW46_RS04375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW46_RS04380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW46_RS04500	COG0735	belongs to the Fur family
EXW46_RS04505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW46_RS04525	COG4555	ABC transporter
EXW46_RS04530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW46_RS04535	COG0067	glutamate synthase
EXW46_RS04535	COG0069	glutamate synthase activity
EXW46_RS04535	COG0070	glutamate synthase
EXW46_RS04540	COG4129	membrane
EXW46_RS04545	COG1132	(ABC) transporter
EXW46_RS04550	COG3557	Belongs to the UPF0374 family
EXW46_RS04570	COG1194	a g-specific adenine glycosylase
EXW46_RS04575	COG1988	membrane-bound metal-dependent
EXW46_RS04600	COG2137	regulation of response to DNA damage stimulus
EXW46_RS04605	COG1090	epimerase
EXW46_RS04610	COG1228	amidohydrolase
EXW46_RS04625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW46_RS04630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW46_RS04645	COG0463	Glycosyl transferase, family 2
EXW46_RS04650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_RS04650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW46_RS04660	COG1216	Glycosyl transferase, family 2
EXW46_RS04675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS04680	COG1263	PTS System
EXW46_RS04680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_RS04685	COG2066	Belongs to the glutaminase family
EXW46_RS04705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_RS04710	COG0833	amino acid
EXW46_RS04720	COG3829	transcription factor binding
EXW46_RS04740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW46_RS04760	COG0535	radical SAM domain protein
EXW46_RS04770	COG0387	Pfam Sodium calcium exchanger
EXW46_RS04775	COG3871	stress protein (general stress protein 26)
EXW46_RS04790	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS04810	COG0697	spore germination
EXW46_RS04815	COG2217	Heavy metal translocating P-type atpase
EXW46_RS04820	COG1295	ribonuclease BN
EXW46_RS04830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW46_RS04835	COG4840	Belongs to the UPF0435 family
EXW46_RS04845	COG3853	Toxic anion resistance protein (TelA)
EXW46_RS04855	COG0861	Integral membrane protein TerC family
EXW46_RS04860	COG2310	stress, protein
EXW46_RS04865	COG2310	stress, protein
EXW46_RS04870	COG2310	stress, protein
EXW46_RS04900	COG2270	Major facilitator Superfamily
EXW46_RS04945	COG0488	(ABC) transporter
EXW46_RS04950	COG1116	anion transmembrane transporter activity
EXW46_RS04955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_RS04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_RS04975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW46_RS04980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW46_RS04985	COG0352	thiamine-phosphate diphosphorylase activity
EXW46_RS04990	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW46_RS05010	COG2190	(PTS) system
EXW46_RS05010	COG1263	PTS System
EXW46_RS05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_RS05015	COG0366	Alpha amylase catalytic
EXW46_RS05020	COG0277	FAD linked oxidase domain protein
EXW46_RS05035	COG0549	Belongs to the carbamate kinase family
EXW46_RS05060	COG0840	transmembrane signaling receptor activity
EXW46_RS05070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS05075	COG0765	amino acid transport
EXW46_RS05085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_RS05085	COG0723	plastoquinol--plastocyanin reductase activity
EXW46_RS05090	COG2814	Major facilitator Superfamily
EXW46_RS05095	COG3541	Predicted nucleotidyltransferase
EXW46_RS05115	COG5002	protein histidine kinase activity
EXW46_RS05140	COG0166	Belongs to the GPI family
EXW46_RS05150	COG0492	ferredoxin-NADP+ reductase activity
EXW46_RS05155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS05160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS05165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS05175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW46_RS05185	COG0450	alkyl hydroperoxide reductase
EXW46_RS05200	COG1473	amidohydrolase
EXW46_RS05205	COG1757	Na H antiporter
EXW46_RS05230	COG4807	Protein conserved in bacteria
EXW46_RS05235	COG5002	protein histidine kinase activity
EXW46_RS05240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW46_RS05250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS05265	COG2309	aminopeptidase activity
EXW46_RS05270	COG2076	Multidrug Resistance protein
EXW46_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS05280	COG0531	amino acid
EXW46_RS05290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW46_RS05295	COG0546	phosphoglycolate phosphatase activity
EXW46_RS05300	COG1597	lipid kinase activity
EXW46_RS05305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW46_RS05310	COG0154	amidase activity
EXW46_RS05320	COG4682	membrane
EXW46_RS05325	COG1846	Transcriptional regulator
EXW46_RS05330	COG0003	Pfam Anion-transporting ATPase
EXW46_RS05345	COG1464	Belongs to the NlpA lipoprotein family
EXW46_RS05350	COG2011	ABC-type metal ion transport system permease component
EXW46_RS05360	COG1335	isochorismatase
EXW46_RS05365	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS05375	COG4851	CamS sex pheromone cAM373 precursor
EXW46_RS05380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW46_RS05385	COG0210	DNA helicase
EXW46_RS05390	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW46_RS05410	COG0151	Belongs to the GarS family
EXW46_RS05415	COG0138	bifunctional purine biosynthesis protein purh
EXW46_RS05420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW46_RS05425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW46_RS05430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW46_RS05435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW46_RS05440	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW46_RS05445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW46_RS05450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW46_RS05455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW46_RS05460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW46_RS05465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW46_RS05490	COG0697	spore germination
EXW46_RS05510	COG0745	RESPONSE REGULATOR receiver
EXW46_RS05515	COG2205	protein histidine kinase activity
EXW46_RS05555	COG1215	transferase activity, transferring glycosyl groups
EXW46_RS05565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_RS05575	COG2226	methyltransferase
EXW46_RS05605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW46_RS05630	COG5002	protein histidine kinase activity
EXW46_RS05640	COG2252	PERMEase
EXW46_RS05645	COG0519	Catalyzes the synthesis of GMP from XMP
EXW46_RS05645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW46_RS05650	COG0459	protein refolding
EXW46_RS05655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW46_RS05660	COG1266	CAAX protease self-immunity
EXW46_RS05670	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW46_RS05675	COG0488	(ABC) transporter
EXW46_RS05685	COG0456	acetyltransferase
EXW46_RS05690	COG1214	PFAM Peptidase M22, glycoprotease
EXW46_RS05695	COG0802	atpase or kinase
EXW46_RS05795	COG2183	response to ionizing radiation
EXW46_RS05800	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW46_RS05805	COG0864	Transcriptional regulator
EXW46_RS05815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW46_RS05820	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW46_RS05825	COG0705	Rhomboid family
EXW46_RS05830	COG4294	response to UV
EXW46_RS05840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW46_RS05850	COG2814	Major facilitator Superfamily
EXW46_RS05860	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_RS05865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW46_RS05895	COG0561	phosphatase activity
EXW46_RS05900	COG4608	Belongs to the ABC transporter superfamily
EXW46_RS05905	COG0444	Belongs to the ABC transporter superfamily
EXW46_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_RS05915	COG0601	transmembrane transport
EXW46_RS05925	COG0747	negative chemotaxis
EXW46_RS05935	COG0842	Transport permease protein
EXW46_RS05940	COG1511	domain protein
EXW46_RS05940	COG0842	Transport permease protein
EXW46_RS05945	COG1131	(ABC) transporter
EXW46_RS05950	COG2197	response regulator
EXW46_RS05955	COG4585	Histidine kinase
EXW46_RS05960	COG0488	(ABC) transporter
EXW46_RS05980	COG5298	Protein conserved in bacteria
EXW46_RS05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS06005	COG1609	Transcriptional regulator
EXW46_RS06015	COG0204	Acyl-transferase
EXW46_RS06030	COG0697	spore germination
EXW46_RS06045	COG1910	domain protein
EXW46_RS06050	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW46_RS06055	COG4149	molybdate abc transporter
EXW46_RS06065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_RS06070	COG0656	L-ascorbic acid biosynthetic process
EXW46_RS06075	COG4166	transmembrane transport
EXW46_RS06080	COG4166	transmembrane transport
EXW46_RS06095	COG2207	Transcriptional regulator
EXW46_RS06105	COG4166	transmembrane transport
EXW46_RS06110	COG4608	Belongs to the ABC transporter superfamily
EXW46_RS06115	COG0444	Belongs to the ABC transporter superfamily
EXW46_RS06120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_RS06125	COG0601	transmembrane transport
EXW46_RS06145	COG2814	Major facilitator Superfamily
EXW46_RS06155	COG2271	Major facilitator Superfamily
EXW46_RS06160	COG0277	FAD linked oxidase domain protein
EXW46_RS06170	COG0604	alcohol dehydrogenase
EXW46_RS06175	COG1464	Belongs to the NlpA lipoprotein family
EXW46_RS06185	COG2011	ABC-type metal ion transport system permease component
EXW46_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS06200	COG4946	Tricorn protease homolog
EXW46_RS06200	COG1506	peptidase
EXW46_RS06200	COG0823	Involved in the tonB-independent uptake of proteins
EXW46_RS06215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW46_RS06220	COG4856	YbbR-like protein
EXW46_RS06225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW46_RS06305	COG0726	polysaccharide deacetylase
EXW46_RS06310	COG2194	sulfuric ester hydrolase activity
EXW46_RS06320	COG0489	protein tyrosine kinase activity
EXW46_RS06325	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS06335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW46_RS06340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW46_RS06350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW46_RS06375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW46_RS06380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW46_RS06385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW46_RS06395	COG0024	Methionine aminopeptidase
EXW46_RS06400	COG0563	adenylate kinase activity
EXW46_RS06405	COG0201	protein transport
EXW46_RS06410	COG0200	Binds to the 23S rRNA
EXW46_RS06415	COG1841	ribosomal large subunit assembly
EXW46_RS06425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW46_RS06435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW46_RS06445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW46_RS06450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW46_RS06460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW46_RS06465	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW46_RS06480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW46_RS06485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW46_RS06490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW46_RS06495	COG0089	rRNA binding
EXW46_RS06500	COG0088	Forms part of the polypeptide exit tunnel
EXW46_RS06505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW46_RS06510	COG0051	transcription antitermination factor activity, RNA binding
EXW46_RS06515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW46_RS06520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW46_RS06530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW46_RS06535	COG1358	cellular component organization or biogenesis
EXW46_RS06540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW46_RS06545	COG0085	RNA polymerase activity
EXW46_RS06550	COG2813	Specifically methylates the guanine in position
EXW46_RS06555	COG0222	ribosome binding
EXW46_RS06560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW46_RS06565	COG0081	regulation of translation
EXW46_RS06570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW46_RS06575	COG0250	Participates in transcription elongation, termination and antitermination
EXW46_RS06580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW46_RS06585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW46_RS06595	COG3688	RNA-binding protein containing a PIN domain
EXW46_RS06600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW46_RS06610	COG0215	cysteine-tRNA ligase activity
EXW46_RS06615	COG1045	serine acetyltransferase
EXW46_RS06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW46_RS06630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW46_RS06635	COG4956	integral membrane protein (PIN domain superfamily)
EXW46_RS06640	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW46_RS06645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW46_RS06650	COG0542	response to heat
EXW46_RS06655	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW46_RS06660	COG3880	PFAM UvrB UvrC protein
EXW46_RS06745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW46_RS06750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW46_RS06755	COG1396	sequence-specific DNA binding
EXW46_RS06760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW46_RS06765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW46_RS06770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW46_RS06775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_RS06780	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW46_RS06785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW46_RS06790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_RS06795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW46_RS06800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW46_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW46_RS06810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW46_RS06820	COG2208	phosphoserine phosphatase activity
EXW46_RS06835	COG1098	S1 RNA binding domain
EXW46_RS06855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW46_RS06860	COG3956	TIGRFAM MazG family protein
EXW46_RS06865	COG2244	polysaccharide biosynthetic process
EXW46_RS06870	COG2002	toxin-antitoxin pair type II binding
EXW46_RS06875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW46_RS06895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW46_RS06900	COG2088	sporulation resulting in formation of a cellular spore
EXW46_RS06905	COG0251	oxidation-reduction process
EXW46_RS06910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_RS06915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW46_RS06925	COG4466	Protein conserved in bacteria
EXW46_RS06935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW46_RS06945	COG0084	hydrolase, TatD family'
EXW46_RS06955	COG2002	toxin-antitoxin pair type II binding
EXW46_RS06960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW46_RS06970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW46_RS06975	COG4467	Involved in initiation control of chromosome replication
EXW46_RS06980	COG1774	PSP1 C-terminal conserved region
EXW46_RS06985	COG0470	DNA polymerase III
EXW46_RS06990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW46_RS06995	COG1982	Orn Lys Arg decarboxylase major
EXW46_RS07040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW46_RS07045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW46_RS07050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW46_RS07060	COG0590	tRNA wobble adenosine to inosine editing
EXW46_RS07065	COG1335	isochorismatase
EXW46_RS07070	COG1428	Deoxynucleoside kinase
EXW46_RS07075	COG1428	Deoxynucleoside kinase
EXW46_RS07095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW46_RS07100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW46_RS07105	COG1686	Belongs to the peptidase S11 family
EXW46_RS07110	COG0517	IMP dehydrogenase activity
EXW46_RS07110	COG0516	GMP reductase activity
EXW46_RS07145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW46_RS07150	COG0187	DNA topoisomerase II activity
EXW46_RS07155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW46_RS07160	COG2501	S4 domain
EXW46_RS07165	COG0592	DNA-directed DNA polymerase activity
EXW46_RS07170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW46_RS07175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW46_RS07180	COG0594	ribonuclease P activity
EXW46_RS07185	COG0706	membrane insertase activity
EXW46_RS07190	COG1847	R3H domain protein
EXW46_RS07195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW46_RS07200	COG0445	tRNA wobble uridine modification
EXW46_RS07210	COG1475	DNA binding
EXW46_RS07215	COG1192	Involved in chromosome partitioning
EXW46_RS07220	COG1475	DNA binding
EXW46_RS07230	COG0668	transmembrane transport
EXW46_RS07235	COG4481	Protein conserved in bacteria
EXW46_RS07240	COG0012	GTP binding
EXW46_RS07245	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW46_RS07250	COG0629	single-stranded DNA binding
EXW46_RS07260	COG4241	membrane
EXW46_RS07265	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW46_RS07270	COG0359	binds to the 23S rRNA
EXW46_RS07275	COG0305	Participates in initiation and elongation during chromosome replication
EXW46_RS07305	COG0745	RESPONSE REGULATOR receiver
EXW46_RS07310	COG5002	protein histidine kinase activity
EXW46_RS07320	COG4853	Protein conserved in bacteria
EXW46_RS07325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW46_RS07330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_RS07340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW46_RS07350	COG1164	Oligoendopeptidase f
EXW46_RS07380	COG1272	protein, Hemolysin III
EXW46_RS07385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW46_RS07435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_RS07440	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW46_RS07445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW46_RS07450	COG2814	Major facilitator Superfamily
EXW46_RS07455	COG3275	phosphorelay sensor kinase activity
EXW46_RS07460	COG3279	Response regulator of the LytR AlgR family
EXW46_RS07465	COG1380	Effector of murein hydrolase LrgA
EXW46_RS07475	COG0628	permease
EXW46_RS07480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_RS07480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_RS07485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW46_RS07490	COG1309	transcriptional regulator
EXW46_RS07495	COG0488	(ABC) transporter
EXW46_RS07505	COG1216	Glycosyl transferase, family 2
EXW46_RS07520	COG1216	Glycosyl transferase, family 2
EXW46_RS07525	COG1607	acyl-coa hydrolase
EXW46_RS07535	COG0840	transmembrane signaling receptor activity
EXW46_RS07560	COG0477	Major facilitator Superfamily
EXW46_RS07565	COG3279	Response regulator of the LytR AlgR family
EXW46_RS07570	COG1966	Carbon starvation protein
EXW46_RS07575	COG2879	small protein
EXW46_RS07580	COG3706	GGDEF domain
EXW46_RS07585	COG0351	phosphomethylpyrimidine kinase
EXW46_RS07590	COG4585	Histidine kinase
EXW46_RS07590	COG2203	Gaf domain
EXW46_RS07595	COG2197	response regulator
EXW46_RS07605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW46_RS07610	COG1011	Hydrolase
EXW46_RS07620	COG2873	o-acetylhomoserine
EXW46_RS07625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW46_RS07630	COG0460	homoserine dehydrogenase
EXW46_RS07640	COG1609	Transcriptional regulator
EXW46_RS07645	COG2755	lipolytic protein G-D-S-L family
EXW46_RS07650	COG1131	(ABC) transporter
EXW46_RS07655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_RS07660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW46_RS07665	COG2814	Major facilitator Superfamily
EXW46_RS07670	COG0561	phosphatase activity
EXW46_RS07675	COG2233	PERMEase
EXW46_RS07690	COG2363	Small membrane protein
EXW46_RS07700	COG3773	Cell wall hydrolase
EXW46_RS07710	COG3253	May function as heme-dependent peroxidase
EXW46_RS07715	COG0280	phosphate acetyltransferase
EXW46_RS07730	COG4844	belongs to the
EXW46_RS07735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS07740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS07745	COG1120	ATPase activity
EXW46_RS07750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS07755	COG1078	dGTPase activity
EXW46_RS07765	COG1994	Peptidase M50
EXW46_RS07775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_RS07780	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_RS07785	COG0789	Transcriptional regulator
EXW46_RS07790	COG2814	Major facilitator Superfamily
EXW46_RS07795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW46_RS07800	COG0010	Belongs to the arginase family
EXW46_RS07815	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_RS07820	COG4506	Protein conserved in bacteria
EXW46_RS07840	COG2234	aminopeptidase activity
EXW46_RS07845	COG0024	Methionine aminopeptidase
EXW46_RS07850	COG1131	(ABC) transporter
EXW46_RS07855	COG0842	Transport permease protein
EXW46_RS07860	COG4585	Histidine kinase
EXW46_RS07865	COG2197	response regulator
EXW46_RS07870	COG3227	Zinc metalloprotease (Elastase)
EXW46_RS07885	COG5001	Diguanylate cyclase
EXW46_RS07885	COG3300	MHYT domain
EXW46_RS07890	COG4294	response to UV
EXW46_RS07895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_RS07900	COG2181	nitrate reductase activity
EXW46_RS07900	COG0247	lactate metabolic process
EXW46_RS07905	COG0183	Belongs to the thiolase family
EXW46_RS07910	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_RS07915	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS07920	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS07930	COG3343	RNA polymerase activity
EXW46_RS07935	COG0504	CTP synthase activity
EXW46_RS07940	COG4821	SIS domain
EXW46_RS07960	COG1494	fructose-1,6-bisphosphatase
EXW46_RS07965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW46_RS07975	COG1435	thymidine kinase activity
EXW46_RS07980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW46_RS07985	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW46_RS08000	COG0009	L-threonylcarbamoyladenylate synthase
EXW46_RS08005	COG1971	Probably functions as a manganese efflux pump
EXW46_RS08015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW46_RS08020	COG2259	Doxx family
EXW46_RS08025	COG2190	(PTS) system
EXW46_RS08035	COG0698	ribose 5-phosphate isomerase
EXW46_RS08070	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW46_RS08080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW46_RS08085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW46_RS08100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW46_RS08105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW46_RS08120	COG3300	MHYT domain
EXW46_RS08120	COG5001	Diguanylate cyclase
EXW46_RS08125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_RS08130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_RS08135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_RS08140	COG0649	NAD binding
EXW46_RS08145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW46_RS08155	COG0839	Belongs to the complex I subunit 6 family
EXW46_RS08160	COG0713	ATP synthesis coupled electron transport
EXW46_RS08165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW46_RS08170	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_RS08175	COG1007	ATP synthesis coupled electron transport
EXW46_RS08180	COG4836	Membrane
EXW46_RS08195	COG2385	sporulation resulting in formation of a cellular spore
EXW46_RS08200	COG3279	Response regulator of the LytR AlgR family
EXW46_RS08215	COG0739	heme binding
EXW46_RS08225	COG1609	Transcriptional regulator
EXW46_RS08240	COG0489	protein tyrosine kinase activity
EXW46_RS08245	COG3944	biosynthesis protein
EXW46_RS08250	COG0489	protein tyrosine kinase activity
EXW46_RS08255	COG4464	protein tyrosine phosphatase activity
EXW46_RS08260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW46_RS08280	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS08285	COG1215	transferase activity, transferring glycosyl groups
EXW46_RS08290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW46_RS08295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW46_RS08300	COG1316	TRANSCRIPTIONal
EXW46_RS08310	COG0745	RESPONSE REGULATOR receiver
EXW46_RS08315	COG5002	protein histidine kinase activity
EXW46_RS08315	COG3850	Histidine kinase
EXW46_RS08330	COG2271	Major facilitator Superfamily
EXW46_RS08350	COG1136	(ABC) transporter
EXW46_RS08355	COG0577	efflux transmembrane transporter activity
EXW46_RS08395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_RS08400	COG4715	Zinc finger, swim domain protein
EXW46_RS08410	COG3584	3D domain protein
EXW46_RS08410	COG1388	LysM domain
EXW46_RS08415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW46_RS08420	COG1215	transferase activity, transferring glycosyl groups
EXW46_RS08430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS08435	COG0791	NLP P60 protein
EXW46_RS08435	COG1388	LysM domain
EXW46_RS08445	COG1368	sulfuric ester hydrolase activity
EXW46_RS08455	COG2389	metal-binding protein
EXW46_RS08465	COG1620	l-lactate permease
EXW46_RS08470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW46_RS08475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_RS08480	COG1294	oxidase, subunit
EXW46_RS08485	COG1271	oxidase subunit
EXW46_RS08495	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW46_RS08500	COG0583	DNA-binding transcription factor activity
EXW46_RS08505	COG1511	domain protein
EXW46_RS08525	COG1301	dicarboxylic acid transport
EXW46_RS08530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS08540	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_RS08555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS08560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS08565	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_RS08570	COG1486	melibiose metabolic process
EXW46_RS08595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW46_RS08595	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW46_RS08605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW46_RS08610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW46_RS08615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW46_RS08620	COG1316	TRANSCRIPTIONal
EXW46_RS08625	COG1739	Uncharacterized protein family UPF0029
EXW46_RS08630	COG1307	EDD domain protein, DegV family
EXW46_RS08635	COG1733	regulation of RNA biosynthetic process
EXW46_RS08640	COG0791	NLP P60 protein
EXW46_RS08640	COG1388	LysM domain
EXW46_RS08645	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW46_RS08650	COG1040	competence protein
EXW46_RS08655	COG1278	Cold shock
EXW46_RS08685	COG1131	(ABC) transporter
EXW46_RS08710	COG2884	Cell division ATP-binding protein ftsE
EXW46_RS08715	COG2177	Part of the ABC transporter FtsEX involved in
EXW46_RS08720	COG0793	Belongs to the peptidase S41A family
EXW46_RS08720	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_RS08725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_RS08730	COG1132	(ABC) transporter
EXW46_RS08740	COG0488	(ABC) transporter
EXW46_RS08745	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW46_RS08750	COG0789	Transcriptional regulator
EXW46_RS08755	COG0583	DNA-binding transcription factor activity
EXW46_RS08785	COG0789	Transcriptional regulator
EXW46_RS08805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW46_RS08815	COG1950	PFAM Membrane protein of
EXW46_RS08820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW46_RS08825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW46_RS08830	COG0546	phosphoglycolate phosphatase activity
EXW46_RS08835	COG0110	maltose O-acetyltransferase activity
EXW46_RS08840	COG0457	Tetratricopeptide repeat
EXW46_RS08845	COG0492	ferredoxin-NADP+ reductase activity
EXW46_RS08855	COG1051	belongs to the nudix hydrolase family
EXW46_RS08860	COG1660	Displays ATPase and GTPase activities
EXW46_RS08865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW46_RS08870	COG1481	regulation of sporulation
EXW46_RS08875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_RS08885	COG2323	membrane
EXW46_RS08900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_RS08925	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW46_RS08940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW46_RS08945	COG0126	phosphoglycerate kinase activity
EXW46_RS08950	COG0149	triose-phosphate isomerase activity
EXW46_RS08960	COG0148	phosphopyruvate hydratase activity
EXW46_RS08975	COG1346	cytolysis
EXW46_RS08980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW46_RS08985	COG1647	Serine aminopeptidase, S33
EXW46_RS08990	COG0557	exoribonuclease II activity
EXW46_RS08995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW46_RS09040	COG2233	PERMEase
EXW46_RS09045	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW46_RS09050	COG0288	reversible hydration of carbon dioxide
EXW46_RS09055	COG1522	sequence-specific DNA binding
EXW46_RS09075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS09100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW46_RS09110	COG0840	transmembrane signaling receptor activity
EXW46_RS09110	COG3290	protein histidine kinase activity
EXW46_RS09140	COG1252	NADH dehydrogenase
EXW46_RS09150	COG1733	regulation of RNA biosynthetic process
EXW46_RS09155	COG2814	Major facilitator Superfamily
EXW46_RS09160	COG0656	L-ascorbic acid biosynthetic process
EXW46_RS09170	COG2910	NAD(P)H-binding
EXW46_RS09175	COG1115	amino acid carrier protein
EXW46_RS09180	COG1115	amino acid carrier protein
EXW46_RS09185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS09190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS09200	COG2311	Membrane
EXW46_RS09205	COG1528	Iron-storage protein
EXW46_RS09215	COG1611	Belongs to the LOG family
EXW46_RS09220	COG2318	DinB family
EXW46_RS09230	COG0783	Belongs to the Dps family
EXW46_RS09235	COG1115	amino acid carrier protein
EXW46_RS09240	COG0490	domain, Protein
EXW46_RS09245	COG0475	glutathione-regulated potassium exporter activity
EXW46_RS09260	COG1741	Belongs to the pirin family
EXW46_RS09265	COG3227	Zinc metalloprotease (Elastase)
EXW46_RS09270	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW46_RS09275	COG0840	transmembrane signaling receptor activity
EXW46_RS09280	COG0840	transmembrane signaling receptor activity
EXW46_RS09290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_RS09300	COG5002	protein histidine kinase activity
EXW46_RS09305	COG0745	RESPONSE REGULATOR receiver
EXW46_RS09310	COG1376	ErfK ybiS ycfS ynhG family protein
EXW46_RS09320	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS09435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS09460	COG0531	amino acid
EXW46_RS09465	COG2814	Major facilitator Superfamily
EXW46_RS09480	COG0840	transmembrane signaling receptor activity
EXW46_RS09485	COG0011	TIGRFAM Protein of
EXW46_RS09495	COG0506	proline dehydrogenase activity
EXW46_RS09500	COG1686	Belongs to the peptidase S11 family
EXW46_RS09510	COG1024	Enoyl-CoA hydratase
EXW46_RS09510	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_RS09515	COG0183	Belongs to the thiolase family
EXW46_RS09520	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS09530	COG1309	transcriptional regulator
EXW46_RS09565	COG1393	Belongs to the ArsC family
EXW46_RS09570	COG0509	glycine decarboxylation via glycine cleavage system
EXW46_RS09575	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW46_RS09580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS09590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW46_RS09595	COG2011	ABC-type metal ion transport system permease component
EXW46_RS09600	COG1464	Belongs to the NlpA lipoprotein family
EXW46_RS09605	COG1464	Belongs to the NlpA lipoprotein family
EXW46_RS09610	COG0396	ATPase activity
EXW46_RS09615	COG0719	Fe-S assembly protein
EXW46_RS09620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW46_RS09625	COG0822	iron-sulfur transferase activity
EXW46_RS09630	COG0719	Fe-S assembly protein
EXW46_RS09635	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS09640	COG3377	Domain of unknown function (DUF1805)
EXW46_RS09650	COG0739	heme binding
EXW46_RS09655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW46_RS09675	COG4377	Putative membrane peptidase family (DUF2324)
EXW46_RS09680	COG0789	Transcriptional regulator
EXW46_RS09690	COG4470	Protein conserved in bacteria
EXW46_RS09705	COG1494	fructose-1,6-bisphosphatase
EXW46_RS09710	COG2445	Protein of unknown function DUF86
EXW46_RS09720	COG0647	UMP catabolic process
EXW46_RS09730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW46_RS09735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW46_RS09745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW46_RS09750	COG4837	Protein of unknown function (DUF1462)
EXW46_RS09795	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW46_RS09800	COG0390	transport system, permease component
EXW46_RS09810	COG1252	NADH dehydrogenase
EXW46_RS09815	COG4844	belongs to the
EXW46_RS09820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW46_RS09825	COG0316	Belongs to the HesB IscA family
EXW46_RS09840	COG1683	Conserved Protein
EXW46_RS09855	COG3708	Transcriptional regulator
EXW46_RS09860	COG0492	ferredoxin-NADP+ reductase activity
EXW46_RS09865	COG1252	NADH dehydrogenase
EXW46_RS09880	COG3584	3D domain protein
EXW46_RS09885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW46_RS09895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW46_RS09900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW46_RS09905	COG1268	BioY protein
EXW46_RS09915	COG2050	protein possibly involved in aromatic compounds catabolism
EXW46_RS09935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_RS09940	COG5018	Exonuclease
EXW46_RS09960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW46_RS09970	COG2267	carboxylic ester hydrolase activity
EXW46_RS09975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW46_RS09980	COG1522	sequence-specific DNA binding
EXW46_RS09985	COG0436	Aminotransferase
EXW46_RS09990	COG1098	S1 RNA binding domain
EXW46_RS09995	COG2155	Conserved Protein
EXW46_RS10000	COG0166	Belongs to the GPI family
EXW46_RS10010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW46_RS10015	COG1285	pathogenesis
EXW46_RS10160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW46_RS10165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW46_RS10170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW46_RS10180	COG0058	SHG alpha-glucan phosphorylase activity
EXW46_RS10200	COG1278	Cold shock
EXW46_RS10205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW46_RS10210	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW46_RS10215	COG1169	isochorismate synthase
EXW46_RS10220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW46_RS10225	COG0596	Alpha beta hydrolase
EXW46_RS10230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW46_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS10240	COG4948	Mandelate Racemase Muconate Lactonizing
EXW46_RS10265	COG3964	amidohydrolase
EXW46_RS10285	COG2188	Transcriptional regulator
EXW46_RS10300	COG0577	efflux transmembrane transporter activity
EXW46_RS10305	COG1136	(ABC) transporter
EXW46_RS10310	COG0577	efflux transmembrane transporter activity
EXW46_RS10315	COG0577	efflux transmembrane transporter activity
EXW46_RS10320	COG2205	protein histidine kinase activity
EXW46_RS10325	COG0745	RESPONSE REGULATOR receiver
EXW46_RS10330	COG0640	Transcriptional regulator
EXW46_RS10335	COG5658	integral membrane protein
EXW46_RS10340	COG1131	(ABC) transporter
EXW46_RS10350	COG2207	Transcriptional regulator
EXW46_RS10350	COG3708	Transcriptional regulator
EXW46_RS10355	COG1136	(ABC) transporter
EXW46_RS10360	COG0577	efflux transmembrane transporter activity
EXW46_RS10405	COG1597	lipid kinase activity
EXW46_RS10410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW46_RS10435	COG0745	RESPONSE REGULATOR receiver
EXW46_RS10440	COG5002	protein histidine kinase activity
EXW46_RS10445	COG3859	Proton-coupled thiamine transporter YuaJ
EXW46_RS10470	COG1842	Phage shock protein A
EXW46_RS10490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS10510	COG1294	oxidase, subunit
EXW46_RS10515	COG1271	oxidase subunit
EXW46_RS10520	COG0288	reversible hydration of carbon dioxide
EXW46_RS10530	COG1854	S-ribosylhomocysteine lyase activity
EXW46_RS10570	COG0494	nUDIX hydrolase
EXW46_RS10575	COG5002	protein histidine kinase activity
EXW46_RS10580	COG0745	RESPONSE REGULATOR receiver
EXW46_RS10585	COG1136	(ABC) transporter
EXW46_RS10590	COG0577	efflux transmembrane transporter activity
EXW46_RS10615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_RS10620	COG1116	anion transmembrane transporter activity
EXW46_RS10625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_RS10640	COG4895	conserved protein (DUF2196)
EXW46_RS10650	COG1368	sulfuric ester hydrolase activity
EXW46_RS10655	COG2267	carboxylic ester hydrolase activity
EXW46_RS10660	COG0753	catalase activity
EXW46_RS10665	COG3852	Histidine kinase
EXW46_RS10670	COG5002	protein histidine kinase activity
EXW46_RS10705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW46_RS10710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW46_RS10735	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW46_RS10745	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS10750	COG0671	phosphoesterase, PA-phosphatase related
EXW46_RS10755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW46_RS10760	COG2267	carboxylic ester hydrolase activity
EXW46_RS10775	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_RS10780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW46_RS10785	COG1242	4 iron, 4 sulfur cluster binding
EXW46_RS10805	COG1136	(ABC) transporter
EXW46_RS10815	COG0582	viral genome integration into host DNA
EXW46_RS10820	COG0490	domain, Protein
EXW46_RS10825	COG0475	glutathione-regulated potassium exporter activity
EXW46_RS10830	COG2814	Major facilitator Superfamily
EXW46_RS10835	COG0495	leucyl-tRNA aminoacylation
EXW46_RS10875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW46_RS10885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_RS10905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW46_RS10910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_RS10915	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW46_RS10920	COG0303	'Molybdopterin
EXW46_RS10925	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW46_RS10930	COG0314	molybdopterin synthase activity
EXW46_RS10955	COG1329	Transcriptional regulator
EXW46_RS10975	COG3832	glyoxalase III activity
EXW46_RS10985	COG2814	Major facilitator Superfamily
EXW46_RS10990	COG2081	HI0933 family
EXW46_RS10995	COG2244	polysaccharide biosynthetic process
EXW46_RS11000	COG1187	pseudouridine synthase activity
EXW46_RS11005	COG1349	DNA-binding transcription factor activity
EXW46_RS11010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_RS11020	COG1523	belongs to the glycosyl hydrolase 13 family
EXW46_RS11025	COG0510	thiamine kinase activity
EXW46_RS11035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW46_RS11040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS11050	COG1363	Peptidase, m42
EXW46_RS11055	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW46_RS11060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS11065	COG4848	Belongs to the UPF0354 family
EXW46_RS11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_RS11085	COG1674	ftsk spoiiie
EXW46_RS11095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW46_RS11100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS11115	COG2309	aminopeptidase activity
EXW46_RS11125	COG3118	belongs to the thioredoxin family
EXW46_RS11130	COG4851	CamS sex pheromone cAM373 precursor
EXW46_RS11145	COG1609	Transcriptional regulator
EXW46_RS11165	COG1970	mechanosensitive ion channel activity
EXW46_RS11175	COG0666	response to abiotic stimulus
EXW46_RS11180	COG5002	protein histidine kinase activity
EXW46_RS11185	COG0745	RESPONSE REGULATOR receiver
EXW46_RS11220	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW46_RS11225	COG0517	IMP dehydrogenase activity
EXW46_RS11230	COG0454	-acetyltransferase
EXW46_RS11235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_RS11245	COG0110	maltose O-acetyltransferase activity
EXW46_RS11255	COG1595	DNA-templated transcription, initiation
EXW46_RS11280	COG0556	nucleotide-excision repair
EXW46_RS11310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW46_RS11315	COG0626	cystathionine gamma-synthase activity
EXW46_RS11320	COG1956	GAF domain-containing protein
EXW46_RS11325	COG1309	transcriptional regulator
EXW46_RS11340	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW46_RS11345	COG1104	cysteine desulfurase activity
EXW46_RS11360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_RS11370	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW46_RS11385	COG3874	Sporulation protein YtfJ
EXW46_RS11390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW46_RS11395	COG0827	DNA restriction-modification system
EXW46_RS11400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW46_RS11420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS11435	COG0137	argininosuccinate synthase activity
EXW46_RS11440	COG0165	Argininosuccinate lyase
EXW46_RS11460	COG0589	response to stress
EXW46_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS11480	COG1476	TRANSCRIPTIONal
EXW46_RS11490	COG0662	Cupin 2, conserved barrel domain protein
EXW46_RS11520	COG0006	proline dipeptidase activity
EXW46_RS11525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW46_RS11535	COG4109	DRTGG domain
EXW46_RS11550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW46_RS11565	COG0587	DNA-directed DNA polymerase activity
EXW46_RS11570	COG0281	malic enzyme
EXW46_RS11575	COG1725	Transcriptional regulator
EXW46_RS11580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW46_RS11590	COG0205	6-phosphofructokinase activity
EXW46_RS11600	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW46_RS11605	COG0628	permease
EXW46_RS11615	COG0372	Belongs to the citrate synthase family
EXW46_RS11620	COG0538	isocitrate dehydrogenase activity
EXW46_RS11625	COG0039	L-malate dehydrogenase activity
EXW46_RS11640	COG0745	RESPONSE REGULATOR receiver
EXW46_RS11645	COG5002	protein histidine kinase activity
EXW46_RS11650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_RS11650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_RS11660	COG1971	Probably functions as a manganese efflux pump
EXW46_RS11665	COG0237	dephospho-CoA kinase activity
EXW46_RS11670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW46_RS11675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW46_RS11680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW46_RS11685	COG3611	Membrane attachment protein
EXW46_RS11690	COG1484	DNA-dependent DNA replication
EXW46_RS11700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW46_RS11715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW46_RS11725	COG1363	Peptidase, m42
EXW46_RS11730	COG1309	transcriptional regulator
EXW46_RS11735	COG1566	PFAM secretion protein HlyD family protein
EXW46_RS11740	COG2814	Major facilitator Superfamily
EXW46_RS11760	COG1418	mRNA catabolic process
EXW46_RS11770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW46_RS11775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW46_RS11810	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW46_RS11815	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW46_RS11820	COG1286	toxin biosynthetic process
EXW46_RS11825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW46_RS11825	COG1796	DNA polymerase
EXW46_RS11830	COG1193	negative regulation of DNA recombination
EXW46_RS11840	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS11845	COG5386	Cell surface protein
EXW46_RS11850	COG5386	Cell surface protein
EXW46_RS11865	COG1120	ATPase activity
EXW46_RS11870	COG4509	Sortase family
EXW46_RS11880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW46_RS11885	COG4895	conserved protein (DUF2196)
EXW46_RS11895	COG0745	RESPONSE REGULATOR receiver
EXW46_RS11900	COG2205	protein histidine kinase activity
EXW46_RS11905	COG1131	(ABC) transporter
EXW46_RS11935	COG2318	DinB family
EXW46_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS11955	COG1309	transcriptional regulator
EXW46_RS11960	COG1024	Enoyl-CoA hydratase
EXW46_RS11965	COG2086	electron transfer activity
EXW46_RS11970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW46_RS11975	COG3118	belongs to the thioredoxin family
EXW46_RS11980	COG0322	excinuclease ABC activity
EXW46_RS11985	COG1719	4-vinyl reductase, 4VR
EXW46_RS11990	COG2009	succinate dehydrogenase
EXW46_RS11995	COG1053	succinate dehydrogenase
EXW46_RS12000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW46_RS12005	COG0824	Thioesterase
EXW46_RS12010	COG1876	peptidase activity
EXW46_RS12015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW46_RS12020	COG1360	Flagellar Motor Protein
EXW46_RS12025	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW46_RS12030	COG4152	abc transporter atp-binding protein
EXW46_RS12035	COG1668	transmembrane transport
EXW46_RS12040	COG1959	2 iron, 2 sulfur cluster binding
EXW46_RS12050	COG0697	spore germination
EXW46_RS12055	COG1396	sequence-specific DNA binding
EXW46_RS12060	COG1983	PspC domain protein
EXW46_RS12065	COG0402	S-adenosylhomocysteine deaminase activity
EXW46_RS12070	COG2233	PERMEase
EXW46_RS12075	COG2197	response regulator
EXW46_RS12085	COG5401	PFAM Sporulation and spore germination
EXW46_RS12090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW46_RS12100	COG0622	Phosphoesterase
EXW46_RS12150	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW46_RS12160	COG0470	DNA polymerase III
EXW46_RS12160	COG1067	ATP-dependent peptidase activity
EXW46_RS12170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW46_RS12175	COG1764	response to oxidative stress
EXW46_RS12180	COG1846	Transcriptional regulator
EXW46_RS12185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW46_RS12190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW46_RS12195	COG0181	hydroxymethylbilane synthase activity
EXW46_RS12200	COG1587	Uroporphyrinogen-III synthase
EXW46_RS12205	COG0113	porphobilinogen synthase activity
EXW46_RS12210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW46_RS12215	COG1388	LysM domain
EXW46_RS12230	COG0285	dihydrofolate synthase activity
EXW46_RS12240	COG0424	maF-like protein
EXW46_RS12245	COG2003	Belongs to the UPF0758 family
EXW46_RS12250	COG1077	Cell shape determining protein MreB Mrl
EXW46_RS12265	COG0850	regulation of cytokinetic process
EXW46_RS12270	COG2894	cell division
EXW46_RS12275	COG0739	heme binding
EXW46_RS12280	COG1994	Peptidase M50
EXW46_RS12285	COG1530	ribonuclease E activity
EXW46_RS12295	COG2868	ribosomal protein
EXW46_RS12305	COG3290	protein histidine kinase activity
EXW46_RS12310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW46_RS12315	COG0745	RESPONSE REGULATOR receiver
EXW46_RS12320	COG5002	protein histidine kinase activity
EXW46_RS12325	COG1136	(ABC) transporter
EXW46_RS12330	COG0577	efflux transmembrane transporter activity
EXW46_RS12335	COG0577	efflux transmembrane transporter activity
EXW46_RS12340	COG0077	Prephenate dehydratase
EXW46_RS12345	COG2258	MOSC domain
EXW46_RS12350	COG1827	regulation of RNA biosynthetic process
EXW46_RS12355	COG1104	cysteine desulfurase activity
EXW46_RS12360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW46_RS12365	COG0157	Belongs to the NadC ModD family
EXW46_RS12370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW46_RS12395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW46_RS12400	COG0632	four-way junction helicase activity
EXW46_RS12405	COG2255	four-way junction helicase activity
EXW46_RS12415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW46_RS12420	COG0343	queuine tRNA-ribosyltransferase activity
EXW46_RS12425	COG1862	Preprotein translocase
EXW46_RS12435	COG2323	membrane
EXW46_RS12440	COG2244	polysaccharide biosynthetic process
EXW46_RS12450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW46_RS12450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW46_RS12455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW46_RS12460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW46_RS12460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW46_RS12465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_RS12470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW46_RS12475	COG1490	D-aminoacyl-tRNA deacylase activity
EXW46_RS12495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW46_RS12500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW46_RS12510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW46_RS12515	COG1959	2 iron, 2 sulfur cluster binding
EXW46_RS12520	COG1104	cysteine desulfurase activity
EXW46_RS12525	COG0482	sulfurtransferase activity
EXW46_RS12535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW46_RS12555	COG0628	permease
EXW46_RS12565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW46_RS12570	COG4472	Bacterial protein of unknown function (DUF965)
EXW46_RS12575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW46_RS12585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW46_RS12590	COG4122	O-methyltransferase activity
EXW46_RS12595	COG0826	peptidase U32
EXW46_RS12600	COG0826	peptidase U32
EXW46_RS12605	COG0572	uridine kinase
EXW46_RS12610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW46_RS12615	COG0768	penicillin binding
EXW46_RS12630	COG2226	methyltransferase
EXW46_RS12635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_RS12640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_RS12645	COG0626	cystathionine gamma-synthase activity
EXW46_RS12650	COG1454	alcohol dehydrogenase
EXW46_RS12650	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS12660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS12700	COG2259	Doxx family
EXW46_RS12705	COG2514	catechol 2,3-dioxygenase activity
EXW46_RS12710	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW46_RS12715	COG3186	Phenylalanine-4-hydroxylase
EXW46_RS12720	COG1404	Belongs to the peptidase S8 family
EXW46_RS12755	COG2267	carboxylic ester hydrolase activity
EXW46_RS12765	COG1785	Belongs to the alkaline phosphatase family
EXW46_RS12775	COG2357	RelA SpoT domain protein
EXW46_RS12780	COG1595	DNA-templated transcription, initiation
EXW46_RS12790	COG0688	phosphatidylethanolamine metabolic process
EXW46_RS12800	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW46_RS12805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW46_RS12810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW46_RS12815	COG1534	Rna-binding protein
EXW46_RS12820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW46_RS12825	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW46_RS12830	COG0799	negative regulation of ribosome biogenesis
EXW46_RS12835	COG2226	methyltransferase
EXW46_RS12840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_RS12845	COG1555	photosystem II stabilization
EXW46_RS12845	COG1596	polysaccharide export
EXW46_RS12850	COG2131	deaminase
EXW46_RS12855	COG2333	competence protein COMEC
EXW46_RS12855	COG0658	competence protein
EXW46_RS12865	COG1466	dna polymerase III delta subunit
EXW46_RS12870	COG0268	Binds directly to 16S ribosomal RNA
EXW46_RS12875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW46_RS12885	COG0481	GTPase activity
EXW46_RS12890	COG1733	regulation of RNA biosynthetic process
EXW46_RS12895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW46_RS12900	COG1420	regulation of RNA biosynthetic process
EXW46_RS12910	COG0443	Heat shock 70 kDa protein
EXW46_RS12915	COG0484	heat shock protein binding
EXW46_RS12925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW46_RS12930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW46_RS12935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW46_RS12940	COG1610	YqeY-like protein
EXW46_RS12955	COG1702	phosphate starvation-inducible protein PhoH
EXW46_RS12960	COG1480	7TM receptor with intracellular HD hydrolase
EXW46_RS12965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW46_RS12970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW46_RS12975	COG0295	cytidine deaminase activity
EXW46_RS12980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW46_RS12990	COG1381	Involved in DNA repair and RecF pathway recombination
EXW46_RS12995	COG0517	IMP dehydrogenase activity
EXW46_RS13000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW46_RS13010	COG0358	DNA primase activity
EXW46_RS13015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW46_RS13020	COG2010	Cytochrome c
EXW46_RS13025	COG2384	SAM-dependent methyltransferase
EXW46_RS13030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW46_RS13035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW46_RS13050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW46_RS13060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS13065	COG1121	(ABC) transporter
EXW46_RS13070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW46_RS13075	COG0735	belongs to the Fur family
EXW46_RS13080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW46_RS13100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_RS13105	COG0477	Major facilitator Superfamily
EXW46_RS13110	COG0768	penicillin binding
EXW46_RS13115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW46_RS13120	COG0573	inorganic phosphate transmembrane transporter activity
EXW46_RS13125	COG0581	inorganic phosphate transmembrane transporter activity
EXW46_RS13135	COG0704	Plays a role in the regulation of phosphate uptake
EXW46_RS13140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW46_RS13145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW46_RS13150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW46_RS13155	COG4483	Protein conserved in bacteria
EXW46_RS13160	COG1940	carbohydrate kinase activity
EXW46_RS13170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS13190	COG0626	cystathionine gamma-synthase activity
EXW46_RS13195	COG0626	cystathionine gamma-synthase activity
EXW46_RS13200	COG0646	methionine synthase
EXW46_RS13200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW46_RS13205	COG1410	methionine synthase
EXW46_RS13205	COG0646	methionine synthase
EXW46_RS13260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW46_RS13265	COG1459	type II secretion system
EXW46_RS13275	COG4970	Tfp pilus assembly protein FimT
EXW46_RS13300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW46_RS13325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_RS13330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW46_RS13335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW46_RS13340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW46_RS13355	COG1725	Transcriptional regulator
EXW46_RS13360	COG1131	(ABC) transporter
EXW46_RS13390	COG2076	Multidrug Resistance protein
EXW46_RS13395	COG2076	Multidrug Resistance protein
EXW46_RS13405	COG1609	Transcriptional regulator
EXW46_RS13415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_RS13445	COG1321	iron dependent repressor
EXW46_RS13450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW46_RS13460	COG3872	metal-dependent enzyme
EXW46_RS13470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW46_RS13475	COG0006	proline dipeptidase activity
EXW46_RS13480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW46_RS13500	COG3854	ATPases associated with a variety of cellular activities
EXW46_RS13545	COG0511	ligase activity, forming carbon-carbon bonds
EXW46_RS13550	COG0439	Biotin carboxylase
EXW46_RS13555	COG1302	Protein conserved in bacteria
EXW46_RS13560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW46_RS13565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW46_RS13570	COG1570	exodeoxyribonuclease VII activity
EXW46_RS13575	COG1722	exodeoxyribonuclease VII activity
EXW46_RS13580	COG0142	geranyltranstransferase activity
EXW46_RS13585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW46_RS13590	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW46_RS13595	COG1438	arginine binding
EXW46_RS13600	COG0497	DNA recombination
EXW46_RS13605	COG0750	zinc metalloprotease
EXW46_RS13610	COG0745	RESPONSE REGULATOR receiver
EXW46_RS13650	COG3093	addiction module antidote protein HigA
EXW46_RS13655	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_RS13665	COG3829	transcription factor binding
EXW46_RS13665	COG3290	protein histidine kinase activity
EXW46_RS13670	COG0280	phosphate acetyltransferase
EXW46_RS13680	COG3426	butyrate kinase activity
EXW46_RS13685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW46_RS13690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_RS13695	COG0022	dehydrogenase e1 component
EXW46_RS13700	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_RS13705	COG0772	Belongs to the SEDS family
EXW46_RS13710	COG2323	membrane
EXW46_RS13715	COG2816	NAD+ diphosphatase activity
EXW46_RS13725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS13730	COG0765	amino acid transport
EXW46_RS13735	COG1126	abc transporter atp-binding protein
EXW46_RS13745	COG4129	membrane
EXW46_RS13750	COG1376	ErfK ybiS ycfS ynhG family protein
EXW46_RS13765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS13770	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_RS13795	COG1234	tRNA 3'-trailer cleavage
EXW46_RS13805	COG1760	l-serine dehydratase
EXW46_RS13810	COG1760	l-serine dehydratase
EXW46_RS13815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_RS13820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS13825	COG0300	oxidoreductase activity
EXW46_RS13835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW46_RS13870	COG1522	sequence-specific DNA binding
EXW46_RS13880	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS13885	COG1757	Na H antiporter
EXW46_RS13895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_RS13905	COG0156	8-amino-7-oxononanoate synthase activity
EXW46_RS13910	COG2226	methyltransferase
EXW46_RS13910	COG1073	alpha beta
EXW46_RS13915	COG4106	trans-aconitate 2-methyltransferase activity
EXW46_RS13920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW46_RS13935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW46_RS13935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW46_RS13940	COG0307	riboflavin synthase, alpha
EXW46_RS13945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW46_RS13945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW46_RS13960	COG1073	alpha beta
EXW46_RS13965	COG0456	acetyltransferase
EXW46_RS13970	COG1609	Transcriptional regulator
EXW46_RS13975	COG2056	Na+-H+ antiporter family
EXW46_RS13980	COG0596	Alpha beta hydrolase
EXW46_RS13995	COG4085	toxin activity
EXW46_RS13995	COG1525	nuclease
EXW46_RS13995	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS14005	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_RS14005	COG0456	acetyltransferase
EXW46_RS14010	COG0656	L-ascorbic acid biosynthetic process
EXW46_RS14015	COG0667	Aldo Keto reductase
EXW46_RS14035	COG1300	Membrane
EXW46_RS14040	COG0735	belongs to the Fur family
EXW46_RS14050	COG4974	Belongs to the 'phage' integrase family
EXW46_RS14060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW46_RS14075	COG0598	Magnesium transport protein CorA
EXW46_RS14090	COG1846	Transcriptional regulator
EXW46_RS14110	COG1131	(ABC) transporter
EXW46_RS14115	COG1725	Transcriptional regulator
EXW46_RS14120	COG1686	Belongs to the peptidase S11 family
EXW46_RS14140	COG0733	neurotransmitter:sodium symporter activity
EXW46_RS14165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_RS14180	COG0697	spore germination
EXW46_RS14185	COG0561	phosphatase activity
EXW46_RS14190	COG4086	secreted protein
EXW46_RS14195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW46_RS14205	COG1547	Domain of unknown function (DUF309)
EXW46_RS14215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW46_RS14220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW46_RS14230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW46_RS14235	COG0363	glucosamine-6-phosphate deaminase activity
EXW46_RS14240	COG2188	Transcriptional regulator
EXW46_RS14250	COG3711	transcriptional antiterminator
EXW46_RS14255	COG1263	PTS System
EXW46_RS14255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_RS14255	COG2190	(PTS) system
EXW46_RS14280	COG0778	Nitroreductase
EXW46_RS14285	COG2199	diguanylate cyclase activity
EXW46_RS14295	COG2084	Dehydrogenase
EXW46_RS14310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW46_RS14315	COG0235	Class ii aldolase
EXW46_RS14325	COG1850	ribulose-bisphosphate carboxylase activity
EXW46_RS14330	COG0436	Aminotransferase
EXW46_RS14335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW46_RS14340	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW46_RS14345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW46_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS14360	COG1695	Transcriptional regulator
EXW46_RS14390	COG0183	Belongs to the thiolase family
EXW46_RS14395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW46_RS14435	COG3842	ATPase activity
EXW46_RS14440	COG0366	Alpha amylase catalytic
EXW46_RS14450	COG2182	Extracellular solute-binding protein
EXW46_RS14455	COG1175	transmembrane transport
EXW46_RS14460	COG3833	ABC-type maltose transport systems, permease component
EXW46_RS14465	COG1609	Transcriptional regulator
EXW46_RS14470	COG0436	Aminotransferase
EXW46_RS14480	COG2205	protein histidine kinase activity
EXW46_RS14490	COG3209	COG3209 Rhs family protein
EXW46_RS14500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW46_RS14510	COG2814	Major facilitator Superfamily
EXW46_RS14555	COG1408	metallophosphoesterase
EXW46_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS14565	COG2200	EAL domain
EXW46_RS14580	COG4703	Protein of unknown function (DUF1797)
EXW46_RS14590	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW46_RS14600	COG0517	IMP dehydrogenase activity
EXW46_RS14605	COG0583	DNA-binding transcription factor activity
EXW46_RS14610	COG2171	N-acyltransferase activity
EXW46_RS14615	COG1473	amidohydrolase
EXW46_RS14625	COG0569	domain protein
EXW46_RS14630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW46_RS14635	COG5503	Protein of unknown function (DUF1447)
EXW46_RS14640	COG0561	phosphatase activity
EXW46_RS14655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_RS14660	COG0022	dehydrogenase e1 component
EXW46_RS14665	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_RS14710	COG1982	Orn Lys Arg decarboxylase major
EXW46_RS14715	COG4476	Belongs to the UPF0223 family
EXW46_RS14720	COG4493	Belongs to the UPF0637 family
EXW46_RS14730	COG0483	inositol monophosphate 1-phosphatase activity
EXW46_RS14740	COG1217	gtp-binding protein TYPA
EXW46_RS14755	COG4896	Protein conserved in bacteria
EXW46_RS14765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW46_RS14770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW46_RS14775	COG4838	Belongs to the UPF0358 family
EXW46_RS14780	COG0772	Belongs to the SEDS family
EXW46_RS14785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW46_RS14790	COG1612	heme a metabolic process
EXW46_RS14795	COG0109	protoheme IX farnesyltransferase activity
EXW46_RS14820	COG3336	cytochrome c oxidase
EXW46_RS14830	COG2340	Cysteine-rich secretory protein family
EXW46_RS14845	COG0406	alpha-ribazole phosphatase activity
EXW46_RS14850	COG3679	Belongs to the UPF0342 family
EXW46_RS14855	COG4471	UPF0298 protein
EXW46_RS14865	COG0742	ribosomal rna small subunit methyltransferase
EXW46_RS14875	COG3314	Sporulation integral membrane protein YlbJ
EXW46_RS14880	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW46_RS14885	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW46_RS14890	COG1323	Belongs to the UPF0348 family
EXW46_RS14895	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW46_RS14900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW46_RS14910	COG0454	-acetyltransferase
EXW46_RS14915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW46_RS14920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW46_RS14925	COG0275	rRNA processing
EXW46_RS14935	COG0768	penicillin binding
EXW46_RS14940	COG0768	penicillin binding
EXW46_RS14945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW46_RS14950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW46_RS14955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW46_RS14960	COG0772	Belongs to the SEDS family
EXW46_RS14975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW46_RS14980	COG0849	cell division
EXW46_RS14985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW46_RS14995	COG1191	sigma factor activity
EXW46_RS15000	COG1191	sigma factor activity
EXW46_RS15005	COG1873	PFAM PRC-barrel domain
EXW46_RS15015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW46_RS15020	COG1799	cell septum assembly
EXW46_RS15025	COG0762	integral membrane protein
EXW46_RS15030	COG2302	S4 RNA-binding domain
EXW46_RS15035	COG3599	regulation of cell shape
EXW46_RS15040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW46_RS15050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW46_RS15055	COG0564	pseudouridine synthase activity
EXW46_RS15060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW46_RS15070	COG0540	Belongs to the ATCase OTCase family
EXW46_RS15075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW46_RS15085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW46_RS15090	COG0543	2 iron, 2 sulfur cluster binding
EXW46_RS15095	COG0167	dihydroorotate dehydrogenase activity
EXW46_RS15105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXW46_RS15115	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW46_RS15130	COG0006	proline dipeptidase activity
EXW46_RS15140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW46_RS15145	COG1561	YicC-like family, N-terminal region
EXW46_RS15160	COG1758	RNA polymerase activity
EXW46_RS15165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW46_RS15170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW46_RS15175	COG0242	peptide deformylase activity
EXW46_RS15180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW46_RS15185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW46_RS15185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW46_RS15190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW46_RS15195	COG0631	protein serine/threonine phosphatase activity
EXW46_RS15200	COG2815	serine threonine protein kinase
EXW46_RS15200	COG0515	serine threonine protein kinase
EXW46_RS15210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW46_RS15215	COG1564	THIamine pyrophosphokinase
EXW46_RS15230	COG1302	Protein conserved in bacteria
EXW46_RS15235	COG1461	Dihydroxyacetone kinase
EXW46_RS15240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW46_RS15245	COG1349	DNA-binding transcription factor activity
EXW46_RS15245	COG2050	protein possibly involved in aromatic compounds catabolism
EXW46_RS15250	COG0416	fatty acid biosynthetic process
EXW46_RS15255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW46_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS15265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_RS15270	COG0571	ribonuclease III activity
EXW46_RS15275	COG1196	nuclear chromosome segregation
EXW46_RS15280	COG0552	protein localization to endoplasmic reticulum
EXW46_RS15290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW46_RS15300	COG1837	Belongs to the UPF0109 family
EXW46_RS15305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW46_RS15310	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW46_RS15315	COG0335	large ribosomal subunit rRNA binding
EXW46_RS15330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW46_RS15335	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW46_RS15340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW46_RS15345	COG0758	DNA mediated transformation
EXW46_RS15350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW46_RS15355	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW46_RS15360	COG4974	Belongs to the 'phage' integrase family
EXW46_RS15365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW46_RS15370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW46_RS15375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW46_RS15380	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW46_RS15385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW46_RS15390	COG0528	UMP kinase activity
EXW46_RS15395	COG0233	cytoplasmic translational termination
EXW46_RS15405	COG4589	Belongs to the CDS family
EXW46_RS15415	COG0750	zinc metalloprotease
EXW46_RS15420	COG0442	prolyl-tRNA aminoacylation
EXW46_RS15430	COG0779	Required for maturation of 30S ribosomal subunits
EXW46_RS15435	COG0195	Participates in both transcription termination and antitermination
EXW46_RS15440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW46_RS15445	COG1358	cellular component organization or biogenesis
EXW46_RS15450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW46_RS15455	COG1550	Protein conserved in bacteria
EXW46_RS15460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW46_RS15470	COG0196	riboflavin kinase activity
EXW46_RS15480	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW46_RS15485	COG0726	polysaccharide deacetylase
EXW46_RS15490	COG0612	Peptidase, M16
EXW46_RS15495	COG1873	PFAM PRC-barrel domain
EXW46_RS15500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW46_RS15505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW46_RS15510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW46_RS15515	COG0527	aspartate kinase activity
EXW46_RS15525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW46_RS15530	COG0740	serine-type endopeptidase activity
EXW46_RS15540	COG1674	ftsk spoiiie
EXW46_RS15550	COG2188	Transcriptional regulator
EXW46_RS15555	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW46_RS15560	COG3845	ABC transporter
EXW46_RS15565	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW46_RS15570	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW46_RS15575	COG0612	Peptidase, M16
EXW46_RS15580	COG0612	Peptidase, M16
EXW46_RS15585	COG0300	oxidoreductase activity
EXW46_RS15600	COG1426	Protein conserved in bacteria
EXW46_RS15605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW46_RS15610	COG1058	Belongs to the CinA family
EXW46_RS15610	COG1546	Belongs to the CinA family
EXW46_RS15630	COG1418	mRNA catabolic process
EXW46_RS15635	COG1692	metallophosphoesterase
EXW46_RS15640	COG2359	stage V sporulation protein S
EXW46_RS15650	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW46_RS15650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW46_RS15655	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW46_RS15660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW46_RS15665	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW46_RS15675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW46_RS15680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW46_RS15685	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW46_RS15695	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_RS15700	COG1368	sulfuric ester hydrolase activity
EXW46_RS15710	COG3773	Cell wall hydrolase
EXW46_RS15720	COG2723	6-phospho-beta-galactosidase activity
EXW46_RS15725	COG2188	Transcriptional regulator
EXW46_RS15735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_RS15745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS15755	COG1346	cytolysis
EXW46_RS15775	COG1086	Polysaccharide biosynthesis protein
EXW46_RS15795	COG5001	Diguanylate cyclase
EXW46_RS15795	COG3300	MHYT domain
EXW46_RS15800	COG0346	lactoylglutathione lyase activity
EXW46_RS15805	COG2267	carboxylic ester hydrolase activity
EXW46_RS15815	COG2364	Membrane
EXW46_RS15820	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_RS15825	COG2706	6-phosphogluconolactonase activity
EXW46_RS15835	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW46_RS15840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW46_RS15845	COG2169	Transcriptional regulator
EXW46_RS15850	COG0708	Exodeoxyribonuclease III
EXW46_RS15855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS15860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS15865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_RS15870	COG1120	ATPase activity
EXW46_RS15875	COG2819	hydrolase of the alpha beta superfamily
EXW46_RS15895	COG1937	Protein conserved in bacteria
EXW46_RS15900	COG2608	mercury ion transmembrane transporter activity
EXW46_RS15905	COG2217	Heavy metal translocating P-type atpase
EXW46_RS15920	COG2116	formate transmembrane transporter activity
EXW46_RS15925	COG1408	metallophosphoesterase
EXW46_RS15935	COG2322	membrane
EXW46_RS15940	COG1979	alcohol dehydrogenase
EXW46_RS15945	COG1349	DNA-binding transcription factor activity
EXW46_RS15950	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW46_RS15955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_RS15955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW46_RS15955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW46_RS15960	COG3584	3D domain protein
EXW46_RS15960	COG1388	LysM domain
EXW46_RS15970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW46_RS15990	COG0464	growth
EXW46_RS16000	COG2860	membrane
EXW46_RS16005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW46_RS16010	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW46_RS16015	COG0789	Transcriptional regulator
EXW46_RS16020	COG0174	glutamine synthetase
EXW46_RS16025	COG3944	biosynthesis protein
EXW46_RS16030	COG0489	protein tyrosine kinase activity
EXW46_RS16035	COG1086	Polysaccharide biosynthesis protein
EXW46_RS16040	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS16045	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS16050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW46_RS16050	COG0463	Glycosyl transferase, family 2
EXW46_RS16070	COG1216	Glycosyl transferase, family 2
EXW46_RS16100	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS16105	COG1216	Glycosyl transferase, family 2
EXW46_RS16105	COG1442	glycosyl transferase family 8
EXW46_RS16110	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW46_RS16120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW46_RS16125	COG0110	maltose O-acetyltransferase activity
EXW46_RS16130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW46_RS16165	COG1132	(ABC) transporter
EXW46_RS16170	COG1695	Transcriptional regulator
EXW46_RS16185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW46_RS16190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW46_RS16200	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS16205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS16215	COG3639	organic phosphonate transmembrane transporter activity
EXW46_RS16235	COG3763	UPF0154 protein
EXW46_RS16240	COG1132	(ABC) transporter
EXW46_RS16245	COG1132	(ABC) transporter
EXW46_RS16265	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_RS16265	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS16275	COG0730	response to heat
EXW46_RS16290	COG1346	cytolysis
EXW46_RS16300	COG0583	DNA-binding transcription factor activity
EXW46_RS16310	COG1131	(ABC) transporter
EXW46_RS16315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_RS16320	COG1473	amidohydrolase
EXW46_RS16330	COG0785	Cytochrome C biogenesis protein
EXW46_RS16335	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW46_RS16360	COG2226	methyltransferase
EXW46_RS16370	COG2986	histidine ammonia-lyase
EXW46_RS16375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW46_RS16380	COG1228	amidohydrolase
EXW46_RS16385	COG0010	Belongs to the arginase family
EXW46_RS16390	COG1329	Transcriptional regulator
EXW46_RS16400	COG1902	pentaerythritol trinitrate reductase activity
EXW46_RS16405	COG0069	glutamate synthase activity
EXW46_RS16410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_RS16415	COG0346	lactoylglutathione lyase activity
EXW46_RS16420	COG0400	carboxylic ester hydrolase activity
EXW46_RS16430	COG5002	protein histidine kinase activity
EXW46_RS16440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS16475	COG1396	sequence-specific DNA binding
EXW46_RS16480	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS16485	COG1268	BioY protein
EXW46_RS16490	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS16495	COG0183	Belongs to the thiolase family
EXW46_RS16510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW46_RS16520	COG2211	Major facilitator Superfamily
EXW46_RS16550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW46_RS16555	COG1266	CAAX protease self-immunity
EXW46_RS16560	COG1132	(ABC) transporter
EXW46_RS16575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS16605	COG0824	Thioesterase
EXW46_RS16610	COG4841	protein insertion into membrane
EXW46_RS16620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW46_RS16620	COG1328	CTP reductase activity
EXW46_RS16630	COG0745	RESPONSE REGULATOR receiver
EXW46_RS16635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_RS16640	COG1832	CoA-binding protein
EXW46_RS16645	COG0187	DNA topoisomerase II activity
EXW46_RS16650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW46_RS16655	COG0673	inositol 2-dehydrogenase activity
EXW46_RS16675	COG1131	(ABC) transporter
EXW46_RS16685	COG4166	transmembrane transport
EXW46_RS16690	COG4166	transmembrane transport
EXW46_RS16695	COG4166	transmembrane transport
EXW46_RS16700	COG2226	methyltransferase
EXW46_RS16735	COG3326	Membrane
EXW46_RS16740	COG2962	Rard protein
EXW46_RS16745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW46_RS16750	COG1657	PFAM Prenyltransferase squalene oxidase
EXW46_RS16760	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS16765	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS16775	COG4145	pantothenate transmembrane transporter activity
EXW46_RS16790	COG0165	Argininosuccinate lyase
EXW46_RS16800	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS16820	COG0494	nUDIX hydrolase
EXW46_RS16830	COG0716	FMN binding
EXW46_RS16840	COG1278	Cold shock
EXW46_RS16865	COG2720	vancomycin resistance protein
EXW46_RS16870	COG0765	amino acid transport
EXW46_RS16875	COG1126	abc transporter atp-binding protein
EXW46_RS16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_RS16885	COG2514	catechol 2,3-dioxygenase activity
EXW46_RS16895	COG1285	pathogenesis
EXW46_RS16915	COG0277	FAD linked oxidase domain protein
EXW46_RS16925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_RS16930	COG2808	Putative FMN-binding domain
EXW46_RS16940	COG0457	Tetratricopeptide repeat
EXW46_RS16955	COG0604	alcohol dehydrogenase
EXW46_RS16960	COG0640	Transcriptional regulator
EXW46_RS16990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS17005	COG3781	membrane
EXW46_RS17030	COG1164	Oligoendopeptidase f
EXW46_RS17035	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW46_RS17055	COG1193	negative regulation of DNA recombination
EXW46_RS17075	COG0583	DNA-binding transcription factor activity
EXW46_RS17105	COG3739	integral membrane protein
EXW46_RS17125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_RS17130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_RS17145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_RS17150	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS17155	COG0534	Mate efflux family protein
EXW46_RS17165	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS17170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_RS17180	COG2814	Major facilitator Superfamily
EXW46_RS17185	COG5002	protein histidine kinase activity
EXW46_RS17190	COG0745	RESPONSE REGULATOR receiver
EXW46_RS17195	COG5002	protein histidine kinase activity
EXW46_RS17215	COG1113	amino acid transport
EXW46_RS17220	COG0604	alcohol dehydrogenase
EXW46_RS17225	COG1695	Transcriptional regulator
EXW46_RS17275	COG2072	flavoprotein involved in K transport
EXW46_RS17315	COG1151	hydroxylamine reductase activity
EXW46_RS17340	COG0814	amino acid
EXW46_RS17380	COG0745	RESPONSE REGULATOR receiver
EXW46_RS17385	COG5002	protein histidine kinase activity
EXW46_RS17410	COG0741	lytic transglycosylase activity
EXW46_RS17450	COG1876	peptidase activity
EXW46_RS17465	COG1191	sigma factor activity
EXW46_RS17480	COG1733	regulation of RNA biosynthetic process
EXW46_RS17485	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW46_RS17490	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS17510	COG0384	phenazine biosynthesis protein PhzF
EXW46_RS17525	COG0494	nUDIX hydrolase
EXW46_RS17540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS17550	COG4702	Belongs to the UPF0303 family
EXW46_RS17555	COG3813	Protein conserved in bacteria
EXW46_RS17560	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW46_RS17565	COG0697	spore germination
EXW46_RS17570	COG0789	Transcriptional regulator
EXW46_RS17575	COG1253	flavin adenine dinucleotide binding
EXW46_RS17585	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW46_RS17605	COG0477	Major facilitator Superfamily
EXW46_RS17640	COG2261	transglycosylase associated protein
EXW46_RS17645	COG0628	permease
EXW46_RS17680	COG2365	Tyrosine phosphatase family
EXW46_RS17685	COG1011	Hydrolase
EXW46_RS17700	COG1595	DNA-templated transcription, initiation
EXW46_RS17730	COG1131	(ABC) transporter
EXW46_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS17760	COG1733	regulation of RNA biosynthetic process
EXW46_RS17765	COG0778	Nitroreductase
EXW46_RS17770	COG1785	Belongs to the alkaline phosphatase family
EXW46_RS17790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW46_RS17795	COG0384	phenazine biosynthesis protein PhzF
EXW46_RS17800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_RS17835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_RS17840	COG2356	endonuclease I
EXW46_RS17845	COG1288	antiporter activity
EXW46_RS17850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW46_RS17905	COG2031	fatty acid transporter
EXW46_RS17925	COG0833	amino acid
EXW46_RS17930	COG1414	Transcriptional regulator
EXW46_RS17935	COG4187	Peptidase family M20/M25/M40
EXW46_RS18035	COG1131	(ABC) transporter
EXW46_RS18050	COG1136	(ABC) transporter
EXW46_RS18065	COG5002	protein histidine kinase activity
EXW46_RS18105	COG2814	Major facilitator Superfamily
EXW46_RS18110	COG1309	transcriptional regulator
EXW46_RS18125	COG4257	antibiotic catabolic process
EXW46_RS18145	COG0640	Transcriptional regulator
EXW46_RS18165	COG2814	Major facilitator Superfamily
EXW46_RS18170	COG1846	Transcriptional regulator
EXW46_RS18185	COG0477	Major facilitator Superfamily
EXW46_RS18225	COG5444	nuclease activity
EXW46_RS18230	COG2849	repeat protein
EXW46_RS18315	COG2814	Major facilitator Superfamily
EXW46_RS18355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW46_RS18375	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_RS18400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS18410	COG5002	protein histidine kinase activity
EXW46_RS18410	COG3850	Histidine kinase
EXW46_RS18425	COG0577	efflux transmembrane transporter activity
EXW46_RS18430	COG1136	(ABC) transporter
EXW46_RS18445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW46_RS18480	COG2318	DinB family
EXW46_RS18495	COG0662	Cupin 2, conserved barrel domain protein
EXW46_RS18545	COG4977	sequence-specific DNA binding
EXW46_RS18595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW46_RS18610	COG2814	Major facilitator Superfamily
EXW46_RS18625	COG0745	RESPONSE REGULATOR receiver
EXW46_RS18630	COG2205	protein histidine kinase activity
EXW46_RS18635	COG1136	(ABC) transporter
EXW46_RS18640	COG0577	efflux transmembrane transporter activity
EXW46_RS18660	COG1136	(ABC) transporter
EXW46_RS18670	COG0277	FAD linked oxidase domain protein
EXW46_RS18715	COG3850	Histidine kinase
EXW46_RS18715	COG5002	protein histidine kinase activity
EXW46_RS18720	COG0745	RESPONSE REGULATOR receiver
EXW46_RS18745	COG0346	lactoylglutathione lyase activity
EXW46_RS18760	COG1522	sequence-specific DNA binding
EXW46_RS18765	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS18770	COG1309	transcriptional regulator
EXW46_RS18775	COG1090	epimerase
EXW46_RS18785	COG0640	Transcriptional regulator
EXW46_RS18790	COG0346	lactoylglutathione lyase activity
EXW46_RS18795	COG0798	PFAM Bile acid sodium symporter
EXW46_RS18815	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW46_RS18825	COG0745	RESPONSE REGULATOR receiver
EXW46_RS18830	COG5002	protein histidine kinase activity
EXW46_RS18900	COG1309	transcriptional regulator
EXW46_RS18905	COG2814	Major facilitator Superfamily
EXW46_RS18915	COG0583	DNA-binding transcription factor activity
EXW46_RS18940	COG1335	isochorismatase
EXW46_RS18945	COG2267	carboxylic ester hydrolase activity
EXW46_RS18950	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS18965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW46_RS18975	COG0574	Belongs to the PEP-utilizing enzyme family
EXW46_RS18975	COG3848	Pyruvate phosphate dikinase
EXW46_RS18990	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW46_RS19010	COG3314	Sporulation integral membrane protein YlbJ
EXW46_RS19020	COG0640	Transcriptional regulator
EXW46_RS19045	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS19055	COG0640	Transcriptional regulator
EXW46_RS19075	COG1414	Transcriptional regulator
EXW46_RS19080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW46_RS19085	COG1984	allophanate hydrolase subunit 2
EXW46_RS19090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW46_RS19105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW46_RS19115	COG0768	penicillin binding
EXW46_RS19145	COG4335	DNA alkylation repair
EXW46_RS19155	COG0833	amino acid
EXW46_RS19165	COG0730	response to heat
EXW46_RS19190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_RS19190	COG0456	acetyltransferase
EXW46_RS19210	COG1671	Belongs to the UPF0178 family
EXW46_RS19215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS19220	COG0697	spore germination
EXW46_RS19235	COG0456	acetyltransferase
EXW46_RS19240	COG2207	Transcriptional regulator
EXW46_RS19270	COG1309	transcriptional regulator
EXW46_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS19285	COG3831	ATPase activity
EXW46_RS19285	COG4884	unkown
EXW46_RS19300	COG2814	Major facilitator Superfamily
EXW46_RS19305	COG2508	Transcriptional regulator
EXW46_RS19315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS19330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_RS19335	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_RS19340	COG2723	6-phospho-beta-galactosidase activity
EXW46_RS19345	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_RS19350	COG1024	Enoyl-CoA hydratase
EXW46_RS19355	COG0183	Belongs to the thiolase family
EXW46_RS19360	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS19370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW46_RS19380	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_RS19400	COG1846	Transcriptional regulator
EXW46_RS19405	COG0778	Nitroreductase
EXW46_RS19415	COG0714	Associated with various cellular activities
EXW46_RS19440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW46_RS19450	COG0753	catalase activity
EXW46_RS19455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW46_RS19475	COG0714	Associated with various cellular activities
EXW46_RS19495	COG0346	lactoylglutathione lyase activity
EXW46_RS19500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS19545	COG3655	Transcriptional regulator
EXW46_RS19555	COG1349	DNA-binding transcription factor activity
EXW46_RS19560	COG1175	transmembrane transport
EXW46_RS19585	COG3842	ATPase activity
EXW46_RS19595	COG3239	Fatty acid desaturase
EXW46_RS19600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_RS19605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW46_RS19610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW46_RS19615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS19645	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_RS19660	COG2226	methyltransferase
EXW46_RS19680	COG2390	Transcriptional regulator
EXW46_RS19685	COG1129	ABC transporter
EXW46_RS19700	COG1879	ABC-type sugar transport system periplasmic component
EXW46_RS19705	COG0579	oxidoreductase
EXW46_RS19735	COG0431	NADPH-dependent FMN reductase
EXW46_RS19740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW46_RS19745	COG0346	lactoylglutathione lyase activity
EXW46_RS19755	COG1388	LysM domain
EXW46_RS19755	COG3584	3D domain protein
EXW46_RS19795	COG0189	ligase activity
EXW46_RS19815	COG1605	Chorismate mutase
EXW46_RS19815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW46_RS19830	COG0287	Prephenate dehydrogenase
EXW46_RS19850	COG0494	nUDIX hydrolase
EXW46_RS19855	COG1309	transcriptional regulator
EXW46_RS19860	COG1033	growth of symbiont in host cell
EXW46_RS19860	COG2409	Drug exporters of the RND superfamily
EXW46_RS19865	COG0488	(ABC) transporter
EXW46_RS19875	COG1368	sulfuric ester hydrolase activity
EXW46_RS19895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_RS19925	COG4912	Dna alkylation repair
EXW46_RS19945	COG2318	DinB family
EXW46_RS19950	COG0697	spore germination
EXW46_RS19970	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW46_RS20000	COG0628	permease
EXW46_RS20040	COG2188	Transcriptional regulator
EXW46_RS20045	COG1131	(ABC) transporter
EXW46_RS20060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW46_RS20070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW46_RS20075	COG0436	Aminotransferase
EXW46_RS20110	COG2226	methyltransferase
EXW46_RS20125	COG2261	transglycosylase associated protein
EXW46_RS20145	COG0477	Major facilitator Superfamily
EXW46_RS20145	COG2814	Major facilitator Superfamily
EXW46_RS20150	COG4533	DNA binding
EXW46_RS20155	COG0789	Transcriptional regulator
EXW46_RS20160	COG1664	Polymer-forming cytoskeletal
EXW46_RS20170	COG2814	Major facilitator Superfamily
EXW46_RS20220	COG1307	EDD domain protein, DegV family
EXW46_RS20225	COG1164	Oligoendopeptidase f
EXW46_RS20235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_RS20260	COG0745	RESPONSE REGULATOR receiver
EXW46_RS20270	COG2936	dipeptidyl-peptidase activity
EXW46_RS20320	COG0667	Aldo Keto reductase
EXW46_RS20340	COG4948	Mandelate Racemase Muconate Lactonizing
EXW46_RS20350	COG4166	transmembrane transport
EXW46_RS20355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW46_RS20370	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS20410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_RS20415	COG3938	Belongs to the proline racemase family
EXW46_RS20425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW46_RS20430	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS20435	COG1115	amino acid carrier protein
EXW46_RS20440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW46_RS20445	COG1162	GTPase activity
EXW46_RS20460	COG2318	DinB family
EXW46_RS20465	COG3397	chitin binding
EXW46_RS20470	COG1227	inorganic diphosphatase activity
EXW46_RS20480	COG4637	Psort location Cytoplasmic, score
EXW46_RS20505	COG0514	ATP-dependent DNA helicase (RecQ)
EXW46_RS20510	COG2105	PFAM AIG2 family protein
EXW46_RS20520	COG3973	AAA domain
EXW46_RS20565	COG2315	Protein conserved in bacteria
EXW46_RS20570	COG2205	protein histidine kinase activity
EXW46_RS20590	COG1819	glycosyl
EXW46_RS20600	COG3397	chitin binding
EXW46_RS20605	COG2153	protein acetylation
EXW46_RS20610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW46_RS20635	COG4175	Glycine betaine
EXW46_RS20635	COG0517	IMP dehydrogenase activity
EXW46_RS20640	COG4176	ABC-type proline glycine betaine transport system permease component
EXW46_RS20675	COG0456	acetyltransferase
EXW46_RS20675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS20690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_RS20695	COG0022	dehydrogenase e1 component
EXW46_RS20700	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_RS20705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW46_RS20740	COG1349	DNA-binding transcription factor activity
EXW46_RS20755	COG3284	Transcriptional regulator
EXW46_RS20770	COG1309	transcriptional regulator
EXW46_RS20775	COG3844	kynureninase activity
EXW46_RS20780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW46_RS20785	COG3483	tryptophan 2,3-dioxygenase activity
EXW46_RS20810	COG2959	enzyme of heme biosynthesis
EXW46_RS20825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS20860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_RS20865	COG3386	PFAM SMP-30 Gluconolaconase
EXW46_RS20875	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW46_RS20880	COG3773	Cell wall hydrolase
EXW46_RS20890	COG0745	RESPONSE REGULATOR receiver
EXW46_RS20895	COG2205	protein histidine kinase activity
EXW46_RS20900	COG0583	DNA-binding transcription factor activity
EXW46_RS20905	COG0667	Aldo Keto reductase
EXW46_RS20910	COG0488	(ABC) transporter
EXW46_RS20925	COG1136	(ABC) transporter
EXW46_RS20930	COG0577	efflux transmembrane transporter activity
EXW46_RS20950	COG0460	homoserine dehydrogenase
EXW46_RS20955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS20965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW46_RS21005	COG2124	cytochrome p450
EXW46_RS21050	COG0561	phosphatase activity
EXW46_RS21055	COG5002	protein histidine kinase activity
EXW46_RS21060	COG0768	penicillin binding
EXW46_RS21070	COG1819	glycosyl
EXW46_RS21075	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_RS21080	COG4720	Psort location CytoplasmicMembrane, score
EXW46_RS21085	COG1122	ATPase activity
EXW46_RS21100	COG2205	protein histidine kinase activity
EXW46_RS21110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_RS21120	COG0745	RESPONSE REGULATOR receiver
EXW46_RS21125	COG5002	protein histidine kinase activity
EXW46_RS21130	COG0604	alcohol dehydrogenase
EXW46_RS21135	COG0671	phosphoesterase, PA-phosphatase related
EXW46_RS21140	COG0768	penicillin binding
EXW46_RS21180	COG2814	Major facilitator Superfamily
EXW46_RS21185	COG1733	regulation of RNA biosynthetic process
EXW46_RS21200	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_RS21215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS21220	COG0697	spore germination
EXW46_RS21240	COG0494	nUDIX hydrolase
EXW46_RS21250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS21260	COG2223	nitrite transmembrane transporter activity
EXW46_RS21265	COG2816	NAD+ diphosphatase activity
EXW46_RS21270	COG0592	DNA-directed DNA polymerase activity
EXW46_RS21275	COG1051	belongs to the nudix hydrolase family
EXW46_RS21315	COG3878	Protein conserved in bacteria
EXW46_RS21335	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW46_RS21350	COG2318	DinB family
EXW46_RS21375	COG0322	excinuclease ABC activity
EXW46_RS21395	COG3961	Belongs to the TPP enzyme family
EXW46_RS21400	COG1132	(ABC) transporter
EXW46_RS21410	COG1183	phosphatidylcholine synthase activity
EXW46_RS21415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_RS21440	COG1011	Hydrolase
EXW46_RS21450	COG0745	RESPONSE REGULATOR receiver
EXW46_RS21455	COG5002	protein histidine kinase activity
EXW46_RS21465	COG1136	(ABC) transporter
EXW46_RS21470	COG0577	efflux transmembrane transporter activity
EXW46_RS21480	COG1073	alpha beta
EXW46_RS21485	COG0657	acetylesterase activity
EXW46_RS21490	COG0076	glutamate decarboxylase activity
EXW46_RS21505	COG1523	belongs to the glycosyl hydrolase 13 family
EXW46_RS21510	COG3227	Zinc metalloprotease (Elastase)
EXW46_RS21515	COG0737	Belongs to the 5'-nucleotidase family
EXW46_RS21525	COG0201	protein transport
EXW46_RS21530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW46_RS21535	COG0697	spore germination
EXW46_RS21540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS21555	COG2323	membrane
EXW46_RS21565	COG1063	alcohol dehydrogenase
EXW46_RS21585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS21590	COG0697	spore germination
EXW46_RS21620	COG1309	transcriptional regulator
EXW46_RS21660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS21675	COG0693	protein deglycase activity
EXW46_RS21695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW46_RS21720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_RS21745	COG1686	Belongs to the peptidase S11 family
EXW46_RS21755	COG0572	uridine kinase
EXW46_RS21800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_RS21805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW46_RS21810	COG1024	Enoyl-CoA hydratase
EXW46_RS21815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_RS21820	COG0511	ligase activity, forming carbon-carbon bonds
EXW46_RS21825	COG0439	Biotin carboxylase
EXW46_RS21830	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS21850	COG1309	transcriptional regulator
EXW46_RS21860	COG1131	(ABC) transporter
EXW46_RS21870	COG1408	metallophosphoesterase
EXW46_RS21880	COG0768	penicillin binding
EXW46_RS21885	COG0768	penicillin binding
EXW46_RS21895	COG1595	DNA-templated transcription, initiation
EXW46_RS21900	COG0768	penicillin binding
EXW46_RS21925	COG1686	Belongs to the peptidase S11 family
EXW46_RS21935	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_RS21960	COG0588	phosphoglycerate mutase activity
EXW46_RS21970	COG0693	protein deglycase activity
EXW46_RS21980	COG0500	methyltransferase
EXW46_RS21980	COG3615	Tellurite resistance protein tehB
EXW46_RS21985	COG1136	(ABC) transporter
EXW46_RS21985	COG0577	efflux transmembrane transporter activity
EXW46_RS22000	COG1309	transcriptional regulator
EXW46_RS22045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW46_RS22055	COG2971	BadF BadG BcrA BcrD
EXW46_RS22060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW46_RS22085	COG2755	lipolytic protein G-D-S-L family
EXW46_RS22085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW46_RS22135	COG2304	oxidoreductase activity
EXW46_RS22155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS22170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS22190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS22205	COG2226	methyltransferase
EXW46_RS22245	COG1595	DNA-templated transcription, initiation
EXW46_RS22250	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW46_RS22260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW46_RS22290	COG1396	sequence-specific DNA binding
EXW46_RS22365	COG1132	(ABC) transporter
EXW46_RS22370	COG1132	(ABC) transporter
EXW46_RS22385	COG2258	MOSC domain
EXW46_RS22395	COG0583	DNA-binding transcription factor activity
EXW46_RS22430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW46_RS22435	COG0583	DNA-binding transcription factor activity
EXW46_RS22445	COG0561	phosphatase activity
EXW46_RS22490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS22500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW46_RS22530	COG1247	-acetyltransferase
EXW46_RS22560	COG0697	spore germination
EXW46_RS22570	COG1309	transcriptional regulator
EXW46_RS22575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_RS22585	COG1846	Transcriptional regulator
EXW46_RS22625	COG1234	tRNA 3'-trailer cleavage
EXW46_RS22635	COG1253	flavin adenine dinucleotide binding
EXW46_RS22645	COG2226	methyltransferase
EXW46_RS22655	COG0028	Belongs to the TPP enzyme family
EXW46_RS22670	COG0596	Alpha beta hydrolase
EXW46_RS22680	COG1136	(ABC) transporter
EXW46_RS22690	COG3655	Transcriptional regulator
EXW46_RS22695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW46_RS22700	COG1187	pseudouridine synthase activity
EXW46_RS22710	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_RS22725	COG1115	amino acid carrier protein
EXW46_RS22730	COG2318	DinB family
EXW46_RS22740	COG0776	regulation of translation
EXW46_RS22755	COG2814	Major facilitator Superfamily
EXW46_RS22760	COG3251	PFAM MbtH domain protein
EXW46_RS22765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW46_RS22770	COG3433	isochorismatase activity
EXW46_RS22770	COG1535	isochorismatase
EXW46_RS22775	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW46_RS22780	COG1169	isochorismate synthase
EXW46_RS22785	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS22790	COG2223	nitrite transmembrane transporter activity
EXW46_RS22810	COG0419	ATPase involved in DNA repair
EXW46_RS22815	COG0420	3'-5' exonuclease activity
EXW46_RS22830	COG1024	Enoyl-CoA hydratase
EXW46_RS22835	COG1280	lysine exporter protein (LysE YggA)
EXW46_RS22840	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS22845	COG2084	Dehydrogenase
EXW46_RS22850	COG1960	acyl-CoA dehydrogenase activity
EXW46_RS22855	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW46_RS22860	COG2079	MmgE PrpD family protein
EXW46_RS22865	COG0372	Belongs to the citrate synthase family
EXW46_RS22875	COG2814	Major facilitator Superfamily
EXW46_RS22885	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_RS22885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_RS22905	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_RS22930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW46_RS22985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS22990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW46_RS22995	COG0671	phosphoesterase, PA-phosphatase related
EXW46_RS23005	COG4991	sh3 domain protein
EXW46_RS23005	COG0515	serine threonine protein kinase
EXW46_RS23005	COG3064	Membrane
EXW46_RS23030	COG4479	Belongs to the UPF0346 family
EXW46_RS23040	COG1509	lysine 2,3-aminomutase activity
EXW46_RS23045	COG3829	transcription factor binding
EXW46_RS23050	COG0456	acetyltransferase
EXW46_RS23055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_RS23060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW46_RS23065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW46_RS23070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_RS23085	COG5506	Protein of unknown function (DUF1694)
EXW46_RS23090	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_RS23095	COG1253	flavin adenine dinucleotide binding
EXW46_RS23130	COG1174	glycine betaine transport
EXW46_RS23135	COG0517	IMP dehydrogenase activity
EXW46_RS23135	COG1125	glycine betaine transport
EXW46_RS23155	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW46_RS23165	COG1070	Carbohydrate kinase
EXW46_RS23180	COG1064	alcohol dehydrogenase
EXW46_RS23185	COG1737	Transcriptional regulator
EXW46_RS23190	COG2197	response regulator
EXW46_RS23195	COG2203	Gaf domain
EXW46_RS23195	COG4585	Histidine kinase
EXW46_RS23200	COG0668	transmembrane transport
EXW46_RS23210	COG1335	isochorismatase
EXW46_RS23250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_RS23255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_RS23260	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS23275	COG0367	asparagine synthase
EXW46_RS23280	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW46_RS23285	COG1999	signal sequence binding
EXW46_RS23290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW46_RS23295	COG1307	EDD domain protein, DegV family
EXW46_RS23305	COG0805	protein transport
EXW46_RS23310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW46_RS23315	COG1272	protein, Hemolysin III
EXW46_RS23330	COG0768	penicillin binding
EXW46_RS23345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS23360	COG0546	phosphoglycolate phosphatase activity
EXW46_RS23370	COG4473	ABC transporter
EXW46_RS23375	COG1131	(ABC) transporter
EXW46_RS23385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW46_RS23390	COG0456	acetyltransferase
EXW46_RS23400	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_RS23405	COG1454	alcohol dehydrogenase
EXW46_RS23410	COG2610	gluconate transmembrane transporter activity
EXW46_RS23435	COG0733	neurotransmitter:sodium symporter activity
EXW46_RS23440	COG0017	Asparaginyl-tRNA synthetase
EXW46_RS23495	COG0018	arginyl-trna synthetase
EXW46_RS23500	COG2136	Putative SAM-dependent methyltransferase
EXW46_RS23500	COG2521	methyltransferase
EXW46_RS23515	COG1413	lyase activity
EXW46_RS23535	COG0488	(ABC) transporter
EXW46_RS23540	COG1418	mRNA catabolic process
EXW46_RS23550	COG2359	stage V sporulation protein S
EXW46_RS23580	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW46_RS23585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW46_RS23590	COG2146	nitrite reductase [NAD(P)H] activity
EXW46_RS23595	COG1587	Uroporphyrinogen-III synthase
EXW46_RS23595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW46_RS23605	COG1648	precorrin-2 dehydrogenase activity
EXW46_RS23615	COG2223	nitrite transmembrane transporter activity
EXW46_RS23625	COG0314	molybdopterin synthase activity
EXW46_RS23630	COG0303	'Molybdopterin
EXW46_RS23635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_RS23640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW46_RS23645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW46_RS23650	COG2181	nitrate reductase activity
EXW46_RS23655	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW46_RS23660	COG1140	nitrate reductase beta subunit
EXW46_RS23665	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW46_RS23670	COG0714	Associated with various cellular activities
EXW46_RS23675	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW46_RS23680	COG1305	Transglutaminase-like
EXW46_RS23685	COG0386	Belongs to the glutathione peroxidase family
EXW46_RS23695	COG0426	domain, Protein
EXW46_RS23695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW46_RS23715	COG1595	DNA-templated transcription, initiation
EXW46_RS23720	COG0604	alcohol dehydrogenase
EXW46_RS23755	COG2226	methyltransferase
EXW46_RS23780	COG3874	Sporulation protein YtfJ
EXW46_RS23860	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_RS23895	COG0456	acetyltransferase
EXW46_RS23920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS23925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS23930	COG1819	glycosyl
EXW46_RS23945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW46_RS23955	COG0561	phosphatase activity
EXW46_RS23965	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS23980	COG2211	Major facilitator Superfamily
EXW46_RS23990	COG0494	nUDIX hydrolase
EXW46_RS23995	COG1876	peptidase activity
EXW46_RS24005	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_RS24020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_RS24025	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS24040	COG1253	flavin adenine dinucleotide binding
EXW46_RS24045	COG2839	Protein conserved in bacteria
EXW46_RS24050	COG0702	epimerase
EXW46_RS24065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_RS24075	COG1607	acyl-coa hydrolase
EXW46_RS24080	COG3689	TIGRFAM TIGR03943 family protein
EXW46_RS24085	COG0701	Predicted permease
EXW46_RS24095	COG2244	polysaccharide biosynthetic process
EXW46_RS24100	COG0586	Pfam SNARE associated Golgi protein
EXW46_RS24105	COG1051	belongs to the nudix hydrolase family
EXW46_RS24110	COG5337	Spore coat protein CotH
EXW46_RS24130	COG0346	lactoylglutathione lyase activity
EXW46_RS24135	COG4166	transmembrane transport
EXW46_RS24145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW46_RS24150	COG1902	pentaerythritol trinitrate reductase activity
EXW46_RS24165	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW46_RS24170	COG0456	acetyltransferase
EXW46_RS24175	COG0523	cobalamin synthesis protein
EXW46_RS24180	COG4989	oxidoreductase activity
EXW46_RS24185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS24190	COG1231	oxidoreductase activity
EXW46_RS24200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW46_RS24215	COG0783	Belongs to the Dps family
EXW46_RS24220	COG3949	Membrane
EXW46_RS24260	COG2814	Major facilitator Superfamily
EXW46_RS24265	COG0667	Aldo Keto reductase
EXW46_RS24270	COG0640	Transcriptional regulator
EXW46_RS24275	COG1404	Belongs to the peptidase S8 family
EXW46_RS24280	COG2002	toxin-antitoxin pair type II binding
EXW46_RS24285	COG0577	efflux transmembrane transporter activity
EXW46_RS24290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW46_RS24320	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW46_RS24330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS24335	COG1279	arginine transmembrane transporter activity
EXW46_RS24340	COG2814	Major facilitator Superfamily
EXW46_RS24350	COG1082	Xylose isomerase domain protein TIM barrel
EXW46_RS24360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_RS24380	COG1247	-acetyltransferase
EXW46_RS24385	COG1285	pathogenesis
EXW46_RS24400	COG5002	protein histidine kinase activity
EXW46_RS24405	COG0745	RESPONSE REGULATOR receiver
EXW46_RS24415	COG1316	TRANSCRIPTIONal
EXW46_RS24430	COG0083	homoserine kinase activity
EXW46_RS24440	COG0460	homoserine dehydrogenase
EXW46_RS24475	COG0300	oxidoreductase activity
EXW46_RS24480	COG5002	protein histidine kinase activity
EXW46_RS24485	COG0745	RESPONSE REGULATOR receiver
EXW46_RS24490	COG1132	(ABC) transporter
EXW46_RS24500	COG0791	NLP P60 protein
EXW46_RS24500	COG1388	LysM domain
EXW46_RS24515	COG1686	Belongs to the peptidase S11 family
EXW46_RS24545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW46_RS24550	COG4988	ABC transporter
EXW46_RS24555	COG1294	oxidase, subunit
EXW46_RS24560	COG1271	oxidase subunit
EXW46_RS24570	COG0346	lactoylglutathione lyase activity
EXW46_RS24585	COG1942	4-Oxalocrotonate Tautomerase
EXW46_RS24595	COG0583	DNA-binding transcription factor activity
EXW46_RS24615	COG0411	ABC transporter
EXW46_RS24625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_RS24630	COG2030	dehydratase
EXW46_RS24635	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_RS24645	COG0523	cobalamin synthesis protein
EXW46_RS24655	COG1231	oxidoreductase activity
EXW46_RS24670	COG0628	permease
EXW46_RS24690	COG0778	Nitroreductase
EXW46_RS24695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW46_RS24700	COG1959	2 iron, 2 sulfur cluster binding
EXW46_RS24705	COG0583	DNA-binding transcription factor activity
EXW46_RS24710	COG0697	spore germination
EXW46_RS24720	COG4549	nuclear export factor GLE1
EXW46_RS24725	COG1276	copper resistance
EXW46_RS24725	COG2372	response to copper ion
EXW46_RS24735	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS24755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW46_RS24765	COG2132	Multicopper oxidase
EXW46_RS24770	COG0006	proline dipeptidase activity
EXW46_RS24795	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW46_RS24810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW46_RS24815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_RS24820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW46_RS24830	COG2390	Transcriptional regulator
EXW46_RS24835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_RS24855	COG1280	lysine exporter protein (LysE YggA)
EXW46_RS24875	COG0531	amino acid
EXW46_RS24880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW46_RS24890	COG1054	Belongs to the UPF0176 family
EXW46_RS24895	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW46_RS24905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_RS24910	COG4166	transmembrane transport
EXW46_RS24955	COG3384	dioxygenase
EXW46_RS24960	COG2814	Major facilitator Superfamily
EXW46_RS24985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW46_RS24990	COG0129	dihydroxy-acid dehydratase activity
EXW46_RS25000	COG0745	RESPONSE REGULATOR receiver
EXW46_RS25005	COG5002	protein histidine kinase activity
EXW46_RS25015	COG2132	Multicopper oxidase
EXW46_RS25020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_RS25035	COG2323	membrane
EXW46_RS25040	COG5566	PFAM Mor transcription activator
EXW46_RS25050	COG0733	neurotransmitter:sodium symporter activity
EXW46_RS25055	COG2244	polysaccharide biosynthetic process
EXW46_RS25070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_RS25075	COG2223	nitrite transmembrane transporter activity
EXW46_RS25080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW46_RS25095	COG0477	Major facilitator Superfamily
EXW46_RS25110	COG1695	Transcriptional regulator
EXW46_RS25120	COG1966	Carbon starvation protein
EXW46_RS25135	COG2814	Major facilitator Superfamily
EXW46_RS25150	COG1051	belongs to the nudix hydrolase family
EXW46_RS25190	COG2502	aspartate--ammonia ligase
EXW46_RS25200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_RS25210	COG1846	Transcriptional regulator
EXW46_RS25215	COG0784	Response regulator, receiver
EXW46_RS25220	COG4191	Histidine kinase
EXW46_RS25225	COG0281	malic enzyme
EXW46_RS25230	COG1027	Aspartate ammonia-lyase
EXW46_RS25240	COG0528	UMP kinase activity
EXW46_RS25245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_RS25260	COG1131	(ABC) transporter
EXW46_RS25295	COG2733	membrane
EXW46_RS25300	COG3048	D-serine ammonia-lyase activity
EXW46_RS25315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_RS25320	COG0785	Cytochrome C biogenesis protein
EXW46_RS25340	COG3340	Belongs to the peptidase S51 family
EXW46_RS25345	COG0534	Mate efflux family protein
EXW46_RS25375	COG1757	Na H antiporter
EXW46_RS25380	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS25380	COG1216	Glycosyl transferase, family 2
EXW46_RS25395	COG0697	spore germination
EXW46_RS25400	COG1802	Transcriptional regulator
EXW46_RS25430	COG0367	asparagine synthase
EXW46_RS25460	COG0406	alpha-ribazole phosphatase activity
EXW46_RS25495	COG1234	tRNA 3'-trailer cleavage
EXW46_RS25510	COG3842	ATPase activity
EXW46_RS25515	COG0583	DNA-binding transcription factor activity
EXW46_RS25525	COG2814	Major facilitator Superfamily
EXW46_RS25540	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_RS25580	COG4786	Flagellar basal body rod
EXW46_RS25585	COG1419	protein localization to endoplasmic reticulum
EXW46_RS25590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW46_RS25595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW46_RS25605	COG1987	bacterial-type flagellum assembly
EXW46_RS25610	COG1338	Plays a role in the flagellum-specific transport system
EXW46_RS25620	COG1776	CheC inhibitor of MCP methylation
EXW46_RS25620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_RS25625	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_RS25635	COG0741	lytic transglycosylase activity
EXW46_RS25640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_RS25645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_RS25650	COG0489	protein tyrosine kinase activity
EXW46_RS25665	COG0314	molybdopterin synthase activity
EXW46_RS25670	COG0303	'Molybdopterin
EXW46_RS25675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_RS25680	COG2116	formate transmembrane transporter activity
EXW46_RS25690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW46_RS25695	COG5609	conserved protein (DUF2294)
EXW46_RS25700	COG2427	Protein of unknown function (DUF1641)
EXW46_RS25705	COG3383	formate dehydrogenase (NAD+) activity
EXW46_RS25715	COG0861	Integral membrane protein TerC family
EXW46_RS25735	COG0835	chemotaxis
EXW46_RS25735	COG0784	Response regulator, receiver
EXW46_RS25770	COG1157	protein secretion by the type III secretion system
EXW46_RS25780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_RS25785	COG1766	The M ring may be actively involved in energy transduction
EXW46_RS25795	COG1558	bacterial-type flagellum-dependent cell motility
EXW46_RS25800	COG1815	bacterial-type flagellum-dependent cell motility
EXW46_RS25815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EXW46_RS25820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_RS25825	COG1256	bacterial-type flagellum assembly
EXW46_RS25845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW46_RS25860	COG1776	CheC inhibitor of MCP methylation
EXW46_RS25860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_RS25865	COG0643	Histidine kinase
EXW46_RS25865	COG2198	Histidine kinase
EXW46_RS25870	COG2201	protein-glutamate methylesterase activity
EXW46_RS25875	COG1360	Flagellar Motor Protein
EXW46_RS25880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW46_RS25890	COG1923	regulation of RNA biosynthetic process
EXW46_RS25910	COG2814	Major facilitator Superfamily
EXW46_RS25945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW46_RS25950	COG2323	membrane
EXW46_RS25960	COG0789	Transcriptional regulator
EXW46_RS25960	COG4978	Transcriptional regulator
EXW46_RS25965	COG0475	glutathione-regulated potassium exporter activity
EXW46_RS25975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_RS25980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_RS25985	COG3162	membrane
EXW46_RS26000	COG1280	lysine exporter protein (LysE YggA)
EXW46_RS26005	COG3403	YqcI/YcgG family
EXW46_RS26040	COG0328	RNA-DNA hybrid ribonuclease activity
EXW46_RS26060	COG0454	-acetyltransferase
EXW46_RS26075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_RS26115	COG2897	thiosulfate sulfurtransferase activity
EXW46_RS26125	COG0456	acetyltransferase
EXW46_RS26135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_RS26145	COG2311	Membrane
EXW46_RS26150	COG2233	PERMEase
EXW46_RS26155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_RS26160	COG0024	Methionine aminopeptidase
EXW46_RS26170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW46_RS26175	COG1199	ATP-dependent helicase activity
EXW46_RS26185	COG0116	Belongs to the methyltransferase superfamily
EXW46_RS26195	COG3599	regulation of cell shape
EXW46_RS26200	COG4474	Belongs to the UPF0398 family
EXW46_RS26235	COG3331	DNA recombination
EXW46_RS26240	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_RS26240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_RS26250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW46_RS26255	COG3935	DnaD domain protein
EXW46_RS26275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW46_RS26275	COG1199	ATP-dependent helicase activity
EXW46_RS26285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW46_RS26290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW46_RS26300	COG0617	tRNA 3'-terminal CCA addition
EXW46_RS26305	COG0438	transferase activity, transferring glycosyl groups
EXW46_RS26310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_RS26315	COG1803	Methylglyoxal synthase
EXW46_RS26320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW46_RS26325	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW46_RS26330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_RS26340	COG2738	Putative neutral zinc metallopeptidase
EXW46_RS26355	COG4347	Protein of unknown function (DUF1405)
EXW46_RS26370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW46_RS26385	COG5582	Belongs to the UPF0302 family
EXW46_RS26390	COG0457	Tetratricopeptide repeat
EXW46_RS26395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW46_RS26405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW46_RS26420	COG0142	geranyltranstransferase activity
EXW46_RS26425	COG2226	methyltransferase
EXW46_RS26430	COG0142	geranyltranstransferase activity
EXW46_RS26435	COG0302	gtp cyclohydrolase
EXW46_RS26445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_RS26465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW46_RS26470	COG1160	GTP binding
EXW46_RS26500	COG1304	FMN binding
EXW46_RS26510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW46_RS26520	COG0252	asparaginase activity
EXW46_RS26525	COG0492	ferredoxin-NADP+ reductase activity
EXW46_RS26545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW46_RS26560	COG1408	metallophosphoesterase
EXW46_RS26570	COG1266	CAAX protease self-immunity
EXW46_RS26575	COG0514	ATP-dependent DNA helicase (RecQ)
EXW46_RS26580	COG4955	Helix-turn-helix domain
EXW46_RS26585	COG1141	Ferredoxin
EXW46_RS26590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW46_RS26600	COG4942	peptidase
EXW46_RS26605	COG2096	Adenosyltransferase
EXW46_RS26610	COG5002	protein histidine kinase activity
EXW46_RS26615	COG0745	RESPONSE REGULATOR receiver
EXW46_RS26620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW46_RS26625	COG1333	cytochrome c biogenesis protein
EXW46_RS26635	COG1187	pseudouridine synthase activity
EXW46_RS26640	COG0700	Nucleoside recognition
EXW46_RS26645	COG2715	membrane protein required for spore maturation
EXW46_RS26650	COG1686	Belongs to the peptidase S11 family
EXW46_RS26655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_RS26670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW46_RS26670	COG0392	lysyltransferase activity
EXW46_RS26685	COG5002	protein histidine kinase activity
EXW46_RS26690	COG0582	viral genome integration into host DNA
EXW46_RS26700	COG1801	Protein of unknown function DUF72
EXW46_RS26705	COG3852	Histidine kinase
EXW46_RS26720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_RS26725	COG1392	Phosphate transport regulator
EXW46_RS26730	COG0306	phosphate transporter
EXW46_RS26735	COG0730	response to heat
EXW46_RS26775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_RS26785	COG1114	Component of the transport system for branched-chain amino acids
EXW46_RS26795	COG2197	response regulator
EXW46_RS26800	COG4585	Histidine kinase
EXW46_RS26805	COG4758	membrane
EXW46_RS26825	COG1757	Na H antiporter
EXW46_RS26850	COG0733	neurotransmitter:sodium symporter activity
EXW46_RS26855	COG1648	precorrin-2 dehydrogenase activity
EXW46_RS26875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW46_RS26920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW46_RS26920	COG2508	Transcriptional regulator
EXW46_RS26925	COG0686	Belongs to the AlaDH PNT family
EXW46_RS26955	COG0745	RESPONSE REGULATOR receiver
EXW46_RS26965	COG0739	heme binding
EXW46_RS27005	COG1073	alpha beta
EXW46_RS27010	COG2732	(Barnase) inhibitor
EXW46_RS27075	COG0531	amino acid
EXW46_RS27080	COG3338	carbonate dehydratase activity
EXW46_RS27090	COG5002	protein histidine kinase activity
EXW46_RS27120	COG5002	protein histidine kinase activity
EXW46_RS27135	COG3227	Zinc metalloprotease (Elastase)
EXW46_RS27170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_RS27180	COG2707	UPF0756 membrane protein
EXW46_RS27190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW46_RS27205	COG1136	(ABC) transporter
EXW46_RS27215	COG5002	protein histidine kinase activity
EXW46_RS27220	COG3842	ATPase activity
EXW46_RS27245	COG0395	ABC-type sugar transport system, permease component
EXW46_RS27250	COG1175	transmembrane transport
EXW46_RS27255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_RS27260	COG1279	arginine transmembrane transporter activity
EXW46_RS27280	COG0745	RESPONSE REGULATOR receiver
EXW46_RS27295	COG1696	Membrane protein involved in D-alanine export
EXW46_RS27315	COG3739	integral membrane protein
EXW46_RS27320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_RS27325	COG1131	(ABC) transporter
EXW46_RS27335	COG3655	Transcriptional regulator
EXW46_RS27370	COG0640	Transcriptional regulator
EXW46_RS27395	COG0823	Involved in the tonB-independent uptake of proteins
EXW46_RS27400	COG5002	protein histidine kinase activity
EXW46_RS27405	COG0745	RESPONSE REGULATOR receiver
EXW46_RS27460	COG2814	Major facilitator Superfamily
EXW46_RS27465	COG0577	efflux transmembrane transporter activity
EXW46_RS27465	COG1136	(ABC) transporter
EXW46_RS27475	COG2205	protein histidine kinase activity
EXW46_RS27480	COG0745	RESPONSE REGULATOR receiver
EXW46_RS27500	COG1136	(ABC) transporter
EXW46_RS27505	COG0577	efflux transmembrane transporter activity
EXW46_RS27525	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_RS27540	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW46_RS27585	COG3493	citrate carrier protein
EXW46_RS27590	COG4565	transcriptional regulatory protein
EXW46_RS27595	COG3290	protein histidine kinase activity
EXW46_RS27640	COG0753	catalase activity
EXW46_RS27665	COG0825	malonyl-CoA metabolic process
EXW46_RS27710	COG2124	cytochrome p450
EXW46_RS27800	COG0529	Catalyzes the synthesis of activated sulfate
EXW46_RS27805	COG2046	Belongs to the sulfate adenylyltransferase family
EXW46_RS27810	COG0175	sulfate reduction
EXW46_RS27820	COG0019	diaminopimelate decarboxylase activity
EXW46_RS27830	COG1368	sulfuric ester hydrolase activity
EXW46_RS27835	COG1183	phosphatidylcholine synthase activity
EXW46_RS27850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW46_RS27855	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW46_RS27865	COG0107	imidazoleglycerol-phosphate synthase activity
EXW46_RS27870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW46_RS27875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW46_RS27880	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW46_RS27890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW46_RS27895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW46_RS27905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW46_RS27915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_RS27925	COG0440	acetolactate synthase activity
EXW46_RS27930	COG0028	Belongs to the TPP enzyme family
EXW46_RS27935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_RS27960	COG3874	Sporulation protein YtfJ
EXW46_RS27970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_RS27990	COG2868	ribosomal protein