locus-tag	class	description
EXW43_RS00015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS00040	COG1404	Belongs to the peptidase S8 family
EXW43_RS00065	COG4974	Belongs to the 'phage' integrase family
EXW43_RS00180	COG1695	Transcriptional regulator
EXW43_RS00260	COG0551	DNA topoisomerase type I activity
EXW43_RS00260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW43_RS00295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW43_RS00325	COG0463	Glycosyl transferase, family 2
EXW43_RS00395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW43_RS00400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW43_RS00405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW43_RS00410	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS00425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW43_RS00430	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS00435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW43_RS00515	COG3773	Cell wall hydrolase
EXW43_RS00595	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW43_RS00610	COG0714	Associated with various cellular activities
EXW43_RS00645	COG4166	transmembrane transport
EXW43_RS00690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW43_RS00695	COG0592	DNA-directed DNA polymerase activity
EXW43_RS00700	COG2501	S4 domain
EXW43_RS00705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW43_RS00710	COG0187	DNA topoisomerase II activity
EXW43_RS00715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW43_RS00750	COG0517	IMP dehydrogenase activity
EXW43_RS00750	COG0516	GMP reductase activity
EXW43_RS00755	COG1686	Belongs to the peptidase S11 family
EXW43_RS00760	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW43_RS00765	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW43_RS00785	COG1428	Deoxynucleoside kinase
EXW43_RS00790	COG1428	Deoxynucleoside kinase
EXW43_RS00795	COG1335	isochorismatase
EXW43_RS00800	COG0590	tRNA wobble adenosine to inosine editing
EXW43_RS00810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW43_RS00815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW43_RS00820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW43_RS00865	COG1982	Orn Lys Arg decarboxylase major
EXW43_RS00870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW43_RS00875	COG0470	DNA polymerase III
EXW43_RS00880	COG1774	PSP1 C-terminal conserved region
EXW43_RS00885	COG4467	Involved in initiation control of chromosome replication
EXW43_RS00890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW43_RS00900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW43_RS00905	COG2002	toxin-antitoxin pair type II binding
EXW43_RS00915	COG0084	hydrolase, TatD family'
EXW43_RS00925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW43_RS00935	COG4466	Protein conserved in bacteria
EXW43_RS00945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW43_RS00950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW43_RS00955	COG0251	oxidation-reduction process
EXW43_RS00960	COG2088	sporulation resulting in formation of a cellular spore
EXW43_RS00965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW43_RS00985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW43_RS00990	COG2002	toxin-antitoxin pair type II binding
EXW43_RS00995	COG2244	polysaccharide biosynthetic process
EXW43_RS01000	COG3956	TIGRFAM MazG family protein
EXW43_RS01005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW43_RS01025	COG1098	S1 RNA binding domain
EXW43_RS01040	COG2208	phosphoserine phosphatase activity
EXW43_RS01050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW43_RS01055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW43_RS01060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW43_RS01065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW43_RS01070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW43_RS01075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW43_RS01080	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW43_RS01085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS01090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW43_RS01095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW43_RS01100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW43_RS01105	COG1396	sequence-specific DNA binding
EXW43_RS01110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW43_RS01115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW43_RS01200	COG3880	PFAM UvrB UvrC protein
EXW43_RS01205	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW43_RS01210	COG0542	response to heat
EXW43_RS01215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW43_RS01220	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW43_RS01225	COG4956	integral membrane protein (PIN domain superfamily)
EXW43_RS01230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW43_RS01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW43_RS01245	COG1045	serine acetyltransferase
EXW43_RS01250	COG0215	cysteine-tRNA ligase activity
EXW43_RS01260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW43_RS01265	COG3688	RNA-binding protein containing a PIN domain
EXW43_RS01275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW43_RS01280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW43_RS01285	COG0250	Participates in transcription elongation, termination and antitermination
EXW43_RS01290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW43_RS01295	COG0081	regulation of translation
EXW43_RS01300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW43_RS01305	COG0222	ribosome binding
EXW43_RS01310	COG2813	Specifically methylates the guanine in position
EXW43_RS01315	COG0085	RNA polymerase activity
EXW43_RS01320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW43_RS01325	COG1358	cellular component organization or biogenesis
EXW43_RS01330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW43_RS01340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW43_RS01345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW43_RS01350	COG0051	transcription antitermination factor activity, RNA binding
EXW43_RS01355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW43_RS01360	COG0088	Forms part of the polypeptide exit tunnel
EXW43_RS01365	COG0089	rRNA binding
EXW43_RS01370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW43_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW43_RS01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW43_RS01395	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW43_RS01400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW43_RS01410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW43_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW43_RS01425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW43_RS01435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW43_RS01445	COG1841	ribosomal large subunit assembly
EXW43_RS01450	COG0200	Binds to the 23S rRNA
EXW43_RS01455	COG0201	protein transport
EXW43_RS01460	COG0563	adenylate kinase activity
EXW43_RS01465	COG0024	Methionine aminopeptidase
EXW43_RS01475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW43_RS01480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW43_RS01485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW43_RS01510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW43_RS01520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW43_RS01525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW43_RS01535	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS01540	COG0489	protein tyrosine kinase activity
EXW43_RS01550	COG2194	sulfuric ester hydrolase activity
EXW43_RS01555	COG0726	polysaccharide deacetylase
EXW43_RS01635	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW43_RS01640	COG4856	YbbR-like protein
EXW43_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW43_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS01675	COG2011	ABC-type metal ion transport system permease component
EXW43_RS01685	COG1464	Belongs to the NlpA lipoprotein family
EXW43_RS01700	COG0277	FAD linked oxidase domain protein
EXW43_RS01705	COG2271	Major facilitator Superfamily
EXW43_RS01715	COG2814	Major facilitator Superfamily
EXW43_RS01730	COG0601	transmembrane transport
EXW43_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW43_RS01740	COG0444	Belongs to the ABC transporter superfamily
EXW43_RS01745	COG4608	Belongs to the ABC transporter superfamily
EXW43_RS01750	COG4166	transmembrane transport
EXW43_RS01760	COG2207	Transcriptional regulator
EXW43_RS01775	COG4166	transmembrane transport
EXW43_RS01780	COG4166	transmembrane transport
EXW43_RS01785	COG0656	L-ascorbic acid biosynthetic process
EXW43_RS01790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW43_RS01805	COG4149	molybdate abc transporter
EXW43_RS01810	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW43_RS01815	COG1910	domain protein
EXW43_RS01830	COG0697	spore germination
EXW43_RS01845	COG0204	Acyl-transferase
EXW43_RS01855	COG1609	Transcriptional regulator
EXW43_RS01865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS01880	COG5298	Protein conserved in bacteria
EXW43_RS01900	COG0488	(ABC) transporter
EXW43_RS01905	COG4585	Histidine kinase
EXW43_RS01910	COG2197	response regulator
EXW43_RS01915	COG1131	(ABC) transporter
EXW43_RS01920	COG0842	Transport permease protein
EXW43_RS01920	COG1511	domain protein
EXW43_RS01925	COG0842	Transport permease protein
EXW43_RS01935	COG0747	negative chemotaxis
EXW43_RS01945	COG0601	transmembrane transport
EXW43_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW43_RS01955	COG0444	Belongs to the ABC transporter superfamily
EXW43_RS01960	COG4608	Belongs to the ABC transporter superfamily
EXW43_RS01965	COG0561	phosphatase activity
EXW43_RS01995	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW43_RS02000	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW43_RS02010	COG0531	amino acid
EXW43_RS02015	COG2814	Major facilitator Superfamily
EXW43_RS02025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW43_RS02035	COG4294	response to UV
EXW43_RS02040	COG0705	Rhomboid family
EXW43_RS02045	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW43_RS02050	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW43_RS02060	COG0864	Transcriptional regulator
EXW43_RS02065	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW43_RS02070	COG2183	response to ionizing radiation
EXW43_RS02170	COG0802	atpase or kinase
EXW43_RS02175	COG1214	PFAM Peptidase M22, glycoprotease
EXW43_RS02180	COG0456	acetyltransferase
EXW43_RS02190	COG0488	(ABC) transporter
EXW43_RS02195	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW43_RS02205	COG1266	CAAX protease self-immunity
EXW43_RS02210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW43_RS02215	COG0459	protein refolding
EXW43_RS02220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW43_RS02220	COG0519	Catalyzes the synthesis of GMP from XMP
EXW43_RS02225	COG2252	PERMEase
EXW43_RS02235	COG5002	protein histidine kinase activity
EXW43_RS02255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW43_RS02315	COG2205	protein histidine kinase activity
EXW43_RS02320	COG0745	RESPONSE REGULATOR receiver
EXW43_RS02340	COG0697	spore germination
EXW43_RS02365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW43_RS02370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW43_RS02375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW43_RS02380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW43_RS02385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW43_RS02390	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW43_RS02395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW43_RS02400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW43_RS02405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW43_RS02410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW43_RS02415	COG0138	bifunctional purine biosynthesis protein purh
EXW43_RS02420	COG0151	Belongs to the GarS family
EXW43_RS02440	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW43_RS02445	COG0210	DNA helicase
EXW43_RS02450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW43_RS02455	COG4851	CamS sex pheromone cAM373 precursor
EXW43_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS02470	COG1335	isochorismatase
EXW43_RS02480	COG2011	ABC-type metal ion transport system permease component
EXW43_RS02485	COG1464	Belongs to the NlpA lipoprotein family
EXW43_RS02500	COG0003	Pfam Anion-transporting ATPase
EXW43_RS02505	COG1846	Transcriptional regulator
EXW43_RS02510	COG4682	membrane
EXW43_RS02520	COG0154	amidase activity
EXW43_RS02525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW43_RS02530	COG1597	lipid kinase activity
EXW43_RS02535	COG0546	phosphoglycolate phosphatase activity
EXW43_RS02540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS02550	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS02555	COG2076	Multidrug Resistance protein
EXW43_RS02560	COG2309	aminopeptidase activity
EXW43_RS02575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS02585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW43_RS02590	COG5002	protein histidine kinase activity
EXW43_RS02595	COG4807	Protein conserved in bacteria
EXW43_RS02620	COG1757	Na H antiporter
EXW43_RS02625	COG1473	amidohydrolase
EXW43_RS02640	COG0450	alkyl hydroperoxide reductase
EXW43_RS02650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW43_RS02660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS02665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS02670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS02675	COG0492	ferredoxin-NADP+ reductase activity
EXW43_RS02685	COG0166	Belongs to the GPI family
EXW43_RS02710	COG5002	protein histidine kinase activity
EXW43_RS02730	COG3541	Predicted nucleotidyltransferase
EXW43_RS02735	COG2814	Major facilitator Superfamily
EXW43_RS02740	COG0723	plastoquinol--plastocyanin reductase activity
EXW43_RS02740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW43_RS02750	COG0765	amino acid transport
EXW43_RS02755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS02765	COG0840	transmembrane signaling receptor activity
EXW43_RS02770	COG0277	FAD linked oxidase domain protein
EXW43_RS02775	COG0366	Alpha amylase catalytic
EXW43_RS02780	COG1263	PTS System
EXW43_RS02780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS02780	COG2190	(PTS) system
EXW43_RS02800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW43_RS02805	COG0352	thiamine-phosphate diphosphorylase activity
EXW43_RS02810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW43_RS02825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW43_RS02830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW43_RS02835	COG1116	anion transmembrane transporter activity
EXW43_RS02840	COG0488	(ABC) transporter
EXW43_RS02885	COG2270	Major facilitator Superfamily
EXW43_RS02915	COG2310	stress, protein
EXW43_RS02920	COG2310	stress, protein
EXW43_RS02925	COG2310	stress, protein
EXW43_RS02930	COG0861	Integral membrane protein TerC family
EXW43_RS02940	COG3853	Toxic anion resistance protein (TelA)
EXW43_RS02950	COG4840	Belongs to the UPF0435 family
EXW43_RS02955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW43_RS02965	COG1295	ribonuclease BN
EXW43_RS02970	COG2217	Heavy metal translocating P-type atpase
EXW43_RS02975	COG0697	spore germination
EXW43_RS02995	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS03010	COG3871	stress protein (general stress protein 26)
EXW43_RS03015	COG0387	Pfam Sodium calcium exchanger
EXW43_RS03025	COG0535	radical SAM domain protein
EXW43_RS03045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW43_RS03065	COG3829	transcription factor binding
EXW43_RS03075	COG0833	amino acid
EXW43_RS03080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW43_RS03100	COG2066	Belongs to the glutaminase family
EXW43_RS03105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS03105	COG1263	PTS System
EXW43_RS03110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW43_RS03125	COG1216	Glycosyl transferase, family 2
EXW43_RS03135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW43_RS03135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW43_RS03140	COG0463	Glycosyl transferase, family 2
EXW43_RS03155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW43_RS03160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW43_RS03175	COG1228	amidohydrolase
EXW43_RS03180	COG1090	epimerase
EXW43_RS03185	COG2137	regulation of response to DNA damage stimulus
EXW43_RS03210	COG1988	membrane-bound metal-dependent
EXW43_RS03215	COG1194	a g-specific adenine glycosylase
EXW43_RS03235	COG3557	Belongs to the UPF0374 family
EXW43_RS03240	COG1132	(ABC) transporter
EXW43_RS03245	COG4129	membrane
EXW43_RS03250	COG0070	glutamate synthase
EXW43_RS03250	COG0069	glutamate synthase activity
EXW43_RS03250	COG0067	glutamate synthase
EXW43_RS03255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW43_RS03260	COG4555	ABC transporter
EXW43_RS03280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW43_RS03285	COG0735	belongs to the Fur family
EXW43_RS03400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW43_RS03405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW43_RS03425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW43_RS03430	COG5001	Diguanylate cyclase
EXW43_RS03430	COG1716	ATPase activity
EXW43_RS03435	COG2766	serine protein kinase
EXW43_RS03440	COG2718	Belongs to the UPF0229 family
EXW43_RS03490	COG1132	(ABC) transporter
EXW43_RS03495	COG1132	(ABC) transporter
EXW43_RS03500	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW43_RS03530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW43_RS03560	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW43_RS03565	COG2268	Band 7 protein
EXW43_RS03575	COG3290	protein histidine kinase activity
EXW43_RS03580	COG4565	transcriptional regulatory protein
EXW43_RS03585	COG2851	Citrate transporter
EXW43_RS03610	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW43_RS03615	COG3842	ATPase activity
EXW43_RS03620	COG1175	transmembrane transport
EXW43_RS03625	COG0395	ABC-type sugar transport system, permease component
EXW43_RS03635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW43_RS03640	COG0745	RESPONSE REGULATOR receiver
EXW43_RS03645	COG5002	protein histidine kinase activity
EXW43_RS03655	COG4990	cell redox homeostasis
EXW43_RS03665	COG3290	protein histidine kinase activity
EXW43_RS03670	COG4565	transcriptional regulatory protein
EXW43_RS03675	COG3493	citrate carrier protein
EXW43_RS03680	COG0281	malic enzyme
EXW43_RS03690	COG0697	spore germination
EXW43_RS03695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS03705	COG5002	protein histidine kinase activity
EXW43_RS03710	COG0745	RESPONSE REGULATOR receiver
EXW43_RS03715	COG0456	acetyltransferase
EXW43_RS03720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW43_RS03725	COG3383	formate dehydrogenase (NAD+) activity
EXW43_RS03730	COG2427	Protein of unknown function (DUF1641)
EXW43_RS03745	COG0531	amino acid
EXW43_RS03755	COG0640	Transcriptional regulator
EXW43_RS03760	COG2217	Heavy metal translocating P-type atpase
EXW43_RS03765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW43_RS03780	COG3227	Zinc metalloprotease (Elastase)
EXW43_RS03800	COG2720	vancomycin resistance protein
EXW43_RS03805	COG1316	TRANSCRIPTIONal
EXW43_RS03810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS03815	COG0346	lactoylglutathione lyase activity
EXW43_RS03820	COG1253	flavin adenine dinucleotide binding
EXW43_RS03825	COG1027	Aspartate ammonia-lyase
EXW43_RS03830	COG1620	l-lactate permease
EXW43_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS03850	COG3104	oligopeptide transport
EXW43_RS03855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS03860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS03865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS03880	COG0156	8-amino-7-oxononanoate synthase activity
EXW43_RS03885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW43_RS03895	COG4548	von Willebrand factor, type A
EXW43_RS03900	COG0714	Associated with various cellular activities
EXW43_RS03920	COG0531	amino acid
EXW43_RS03925	COG2188	Transcriptional regulator
EXW43_RS03930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS03930	COG1263	PTS System
EXW43_RS03935	COG0366	Alpha amylase catalytic
EXW43_RS03950	COG0697	spore germination
EXW43_RS03955	COG4585	Histidine kinase
EXW43_RS03960	COG2197	response regulator
EXW43_RS03965	COG1404	Belongs to the peptidase S8 family
EXW43_RS03980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW43_RS03985	COG1115	amino acid carrier protein
EXW43_RS03990	COG1126	abc transporter atp-binding protein
EXW43_RS03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS04000	COG0765	amino acid transport
EXW43_RS04005	COG0765	amino acid transport
EXW43_RS04010	COG0833	amino acid
EXW43_RS04035	COG2378	regulation of single-species biofilm formation
EXW43_RS04040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW43_RS04045	COG5002	protein histidine kinase activity
EXW43_RS04060	COG0659	secondary active sulfate transmembrane transporter activity
EXW43_RS04075	COG2271	Major facilitator Superfamily
EXW43_RS04080	COG1846	Transcriptional regulator
EXW43_RS04085	COG0477	Major facilitator Superfamily
EXW43_RS04090	COG1609	Transcriptional regulator
EXW43_RS04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW43_RS04100	COG1869	D-ribose catabolic process
EXW43_RS04110	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW43_RS04115	COG1879	ABC-type sugar transport system periplasmic component
EXW43_RS04145	COG1063	alcohol dehydrogenase
EXW43_RS04160	COG3568	Endonuclease Exonuclease Phosphatase
EXW43_RS04190	COG0840	transmembrane signaling receptor activity
EXW43_RS04195	COG1388	LysM domain
EXW43_RS04195	COG3584	3D domain protein
EXW43_RS04200	COG1476	TRANSCRIPTIONal
EXW43_RS04220	COG3104	oligopeptide transport
EXW43_RS04225	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS04240	COG1113	amino acid transport
EXW43_RS04245	COG2252	PERMEase
EXW43_RS04260	COG2153	protein acetylation
EXW43_RS04270	COG0569	domain protein
EXW43_RS04270	COG0475	glutathione-regulated potassium exporter activity
EXW43_RS04280	COG1845	cytochrome c oxidase, subunit III
EXW43_RS04285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW43_RS04295	COG0833	amino acid
EXW43_RS04300	COG4990	cell redox homeostasis
EXW43_RS04315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW43_RS04320	COG0697	spore germination
EXW43_RS04325	COG0531	amino acid
EXW43_RS04335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW43_RS04340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW43_RS04350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW43_RS04355	COG0573	inorganic phosphate transmembrane transporter activity
EXW43_RS04360	COG0581	inorganic phosphate transmembrane transporter activity
EXW43_RS04370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW43_RS04490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW43_RS04505	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS04505	COG3103	Sh3 type 3 domain protein
EXW43_RS04505	COG4991	sh3 domain protein
EXW43_RS04510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW43_RS04515	COG1116	anion transmembrane transporter activity
EXW43_RS04520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW43_RS04525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW43_RS04530	COG0352	thiamine-phosphate diphosphorylase activity
EXW43_RS04535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW43_RS04540	COG2104	thiamine diphosphate biosynthetic process
EXW43_RS04545	COG2022	thiamine diphosphate biosynthetic process
EXW43_RS04550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW43_RS04555	COG0351	phosphomethylpyrimidine kinase
EXW43_RS04580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW43_RS04585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW43_RS04590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW43_RS04595	COG2205	protein histidine kinase activity
EXW43_RS04600	COG2814	Major facilitator Superfamily
EXW43_RS04605	COG1846	Transcriptional regulator
EXW43_RS04625	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW43_RS04630	COG1129	ABC transporter
EXW43_RS04635	COG1879	ABC-type sugar transport system periplasmic component
EXW43_RS04640	COG2252	PERMEase
EXW43_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS04660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW43_RS04665	COG1621	beta-fructofuranosidase activity
EXW43_RS04670	COG1263	PTS System
EXW43_RS04670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS04675	COG1609	Transcriptional regulator
EXW43_RS04725	COG0778	Nitroreductase
EXW43_RS04730	COG2719	SpoVR family
EXW43_RS04755	COG1937	Protein conserved in bacteria
EXW43_RS04760	COG0425	Belongs to the sulfur carrier protein TusA family
EXW43_RS04760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS04765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS04765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS04770	COG0425	Belongs to the sulfur carrier protein TusA family
EXW43_RS04775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS04775	COG0425	Belongs to the sulfur carrier protein TusA family
EXW43_RS04780	COG2210	Belongs to the sulfur carrier protein TusA family
EXW43_RS04785	COG0730	response to heat
EXW43_RS04795	COG1316	TRANSCRIPTIONal
EXW43_RS04800	COG0604	alcohol dehydrogenase
EXW43_RS04805	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW43_RS04810	COG0604	alcohol dehydrogenase
EXW43_RS04815	COG2814	Major facilitator Superfamily
EXW43_RS04825	COG3711	transcriptional antiterminator
EXW43_RS04825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW43_RS04830	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW43_RS04835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW43_RS04860	COG1388	LysM domain
EXW43_RS04860	COG3584	3D domain protein
EXW43_RS04865	COG0577	efflux transmembrane transporter activity
EXW43_RS04870	COG1136	(ABC) transporter
EXW43_RS04880	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW43_RS04895	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS04900	COG3546	catalase activity
EXW43_RS04930	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS04955	COG0531	amino acid
EXW43_RS04960	COG0475	glutathione-regulated potassium exporter activity
EXW43_RS04970	COG1737	Transcriptional regulator
EXW43_RS04975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW43_RS04980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS04980	COG1263	PTS System
EXW43_RS04990	COG2259	Doxx family
EXW43_RS05010	COG0697	spore germination
EXW43_RS05015	COG1522	sequence-specific DNA binding
EXW43_RS05025	COG0300	oxidoreductase activity
EXW43_RS05040	COG2076	Multidrug Resistance protein
EXW43_RS05045	COG1309	transcriptional regulator
EXW43_RS05050	COG2814	Major facilitator Superfamily
EXW43_RS05055	COG1733	regulation of RNA biosynthetic process
EXW43_RS05070	COG4533	DNA binding
EXW43_RS05075	COG2211	Major facilitator Superfamily
EXW43_RS05085	COG0693	protein deglycase activity
EXW43_RS05095	COG0531	amino acid
EXW43_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS05105	COG1132	(ABC) transporter
EXW43_RS05110	COG1132	(ABC) transporter
EXW43_RS05115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS05120	COG0765	amino acid transport
EXW43_RS05125	COG1126	abc transporter atp-binding protein
EXW43_RS05140	COG0189	ligase activity
EXW43_RS05150	COG4399	Belongs to the UPF0754 family
EXW43_RS05155	COG3679	Belongs to the UPF0342 family
EXW43_RS05170	COG0028	Belongs to the TPP enzyme family
EXW43_RS05175	COG3527	Alpha-acetolactate decarboxylase
EXW43_RS05180	COG0463	Glycosyl transferase, family 2
EXW43_RS05185	COG1216	Glycosyl transferase, family 2
EXW43_RS05190	COG2094	Belongs to the DNA glycosylase MPG family
EXW43_RS05195	COG0561	phosphatase activity
EXW43_RS05205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW43_RS05210	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS05220	COG0659	secondary active sulfate transmembrane transporter activity
EXW43_RS05230	COG2244	polysaccharide biosynthetic process
EXW43_RS05250	COG1696	Membrane protein involved in D-alanine export
EXW43_RS05265	COG1024	Enoyl-CoA hydratase
EXW43_RS05280	COG1363	Peptidase, m42
EXW43_RS05295	COG2318	DinB family
EXW43_RS05315	COG0579	oxidoreductase
EXW43_RS05350	COG0601	transmembrane transport
EXW43_RS05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW43_RS05360	COG0444	Belongs to the ABC transporter superfamily
EXW43_RS05365	COG4608	Belongs to the ABC transporter superfamily
EXW43_RS05420	COG5444	nuclease activity
EXW43_RS05455	COG0477	Major facilitator Superfamily
EXW43_RS05460	COG3290	protein histidine kinase activity
EXW43_RS05465	COG4565	transcriptional regulatory protein
EXW43_RS05470	COG3181	Tripartite tricarboxylate transporter family receptor
EXW43_RS05485	COG1074	ATP-dependent DNA helicase activity
EXW43_RS05555	COG0305	Participates in initiation and elongation during chromosome replication
EXW43_RS05585	COG0477	Major facilitator Superfamily
EXW43_RS05670	COG2814	Major facilitator Superfamily
EXW43_RS05675	COG0640	Transcriptional regulator
EXW43_RS05695	COG2376	Dihydroxyacetone kinase
EXW43_RS05705	COG2376	Dihydroxyacetone kinase
EXW43_RS05720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW43_RS05735	COG1335	isochorismatase
EXW43_RS05740	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS05760	COG0076	glutamate decarboxylase activity
EXW43_RS05785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW43_RS05790	COG1278	Cold shock
EXW43_RS05800	COG2409	Drug exporters of the RND superfamily
EXW43_RS05825	COG3237	CsbD-like
EXW43_RS05845	COG2172	sigma factor antagonist activity
EXW43_RS05850	COG1191	sigma factor activity
EXW43_RS05860	COG2208	phosphoserine phosphatase activity
EXW43_RS05865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW43_RS05870	COG0784	Response regulator, receiver
EXW43_RS05870	COG2205	protein histidine kinase activity
EXW43_RS05870	COG5002	protein histidine kinase activity
EXW43_RS05900	COG2807	transmembrane transport
EXW43_RS05905	COG2186	Transcriptional regulator
EXW43_RS05910	COG4585	Histidine kinase
EXW43_RS05915	COG2197	response regulator
EXW43_RS05945	COG0420	3'-5' exonuclease activity
EXW43_RS05950	COG4717	serine-type aminopeptidase activity
EXW43_RS05955	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW43_RS05965	COG0346	lactoylglutathione lyase activity
EXW43_RS05970	COG0346	lactoylglutathione lyase activity
EXW43_RS05985	COG2267	carboxylic ester hydrolase activity
EXW43_RS05995	COG2140	Oxalate decarboxylase
EXW43_RS06000	COG3620	sequence-specific DNA binding
EXW43_RS06005	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW43_RS06010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW43_RS06015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW43_RS06020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW43_RS06025	COG1695	Transcriptional regulator
EXW43_RS06035	COG1595	DNA-templated transcription, initiation
EXW43_RS06050	COG3973	AAA domain
EXW43_RS06055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW43_RS06070	COG1846	Transcriptional regulator
EXW43_RS06080	COG0537	adenosine 5'-monophosphoramidase activity
EXW43_RS06085	COG1131	(ABC) transporter
EXW43_RS06090	COG4473	ABC transporter
EXW43_RS06100	COG0247	lactate metabolic process
EXW43_RS06105	COG1139	Iron-sulfur cluster binding protein
EXW43_RS06110	COG1556	Lactate utilization protein
EXW43_RS06130	COG3402	PFAM membrane-flanked domain
EXW43_RS06135	COG3428	Bacterial PH domain
EXW43_RS06175	COG3402	PFAM membrane-flanked domain
EXW43_RS06180	COG3428	Bacterial PH domain
EXW43_RS06185	COG2329	Antibiotic biosynthesis monooxygenase
EXW43_RS06190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS06195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW43_RS06200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW43_RS06205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW43_RS06230	COG1309	transcriptional regulator
EXW43_RS06235	COG1511	domain protein
EXW43_RS06270	COG2378	regulation of single-species biofilm formation
EXW43_RS06275	COG1609	Transcriptional regulator
EXW43_RS06285	COG1234	tRNA 3'-trailer cleavage
EXW43_RS06290	COG0095	Lipoate-protein ligase
EXW43_RS06300	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS06315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW43_RS06320	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW43_RS06325	COG4208	sulfate ABC transporter
EXW43_RS06340	COG1408	metallophosphoesterase
EXW43_RS06345	COG1078	dGTPase activity
EXW43_RS06360	COG1595	DNA-templated transcription, initiation
EXW43_RS06365	COG3708	Transcriptional regulator
EXW43_RS06365	COG2207	Transcriptional regulator
EXW43_RS06370	COG2205	protein histidine kinase activity
EXW43_RS06375	COG0745	RESPONSE REGULATOR receiver
EXW43_RS06390	COG0501	Belongs to the peptidase M48B family
EXW43_RS06395	COG0697	spore germination
EXW43_RS06420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW43_RS06425	COG2224	Isocitrate lyase
EXW43_RS06435	COG1278	Cold shock
EXW43_RS06445	COG4903	ComK protein
EXW43_RS06450	COG0398	Pfam SNARE associated Golgi protein
EXW43_RS06460	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW43_RS06465	COG1074	ATP-dependent DNA helicase activity
EXW43_RS06515	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW43_RS06540	COG0367	asparagine synthase
EXW43_RS06550	COG0753	catalase activity
EXW43_RS06555	COG0004	ammonium transporteR
EXW43_RS06565	COG1666	GTP binding
EXW43_RS06570	COG2996	Protein conserved in bacteria
EXW43_RS06575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW43_RS06585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS06600	COG0561	phosphatase activity
EXW43_RS06620	COG2267	carboxylic ester hydrolase activity
EXW43_RS06635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS06640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW43_RS06645	COG5504	Zn-dependent protease
EXW43_RS06655	COG0180	Tryptophanyl-tRNA synthetase
EXW43_RS06665	COG4166	transmembrane transport
EXW43_RS06670	COG0601	transmembrane transport
EXW43_RS06675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW43_RS06680	COG0444	Belongs to the ABC transporter superfamily
EXW43_RS06685	COG4608	Belongs to the ABC transporter superfamily
EXW43_RS06690	COG0534	Mate efflux family protein
EXW43_RS06695	COG4166	transmembrane transport
EXW43_RS06710	COG0861	Integral membrane protein TerC family
EXW43_RS06715	COG4862	establishment of competence for transformation
EXW43_RS06720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW43_RS06730	COG1164	Oligoendopeptidase f
EXW43_RS06745	COG2346	COG2346, Truncated hemoglobins
EXW43_RS06750	COG4116	CYTH
EXW43_RS06760	COG2357	RelA SpoT domain protein
EXW43_RS06770	COG0564	pseudouridine synthase activity
EXW43_RS06780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW43_RS06785	COG0772	Belongs to the SEDS family
EXW43_RS06790	COG1216	Glycosyl transferase, family 2
EXW43_RS06810	COG0463	Glycosyl transferase, family 2
EXW43_RS06810	COG0457	Tetratricopeptide repeat
EXW43_RS06830	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW43_RS06845	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW43_RS06890	COG2153	protein acetylation
EXW43_RS06895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW43_RS06900	COG2382	esterase
EXW43_RS06925	COG5492	domain, Protein
EXW43_RS06930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW43_RS06940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW43_RS06940	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW43_RS06945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW43_RS06950	COG0134	indole-3-glycerol-phosphate synthase activity
EXW43_RS06955	COG0135	phosphoribosylanthranilate isomerase activity
EXW43_RS06960	COG0133	tryptophan synthase activity
EXW43_RS06965	COG0159	tryptophan synthase activity
EXW43_RS06975	COG1620	l-lactate permease
EXW43_RS06980	COG5634	Uncharacterized conserved protein (DUF2278)
EXW43_RS07035	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW43_RS07040	COG0567	Dehydrogenase, E1 component
EXW43_RS07045	COG1476	TRANSCRIPTIONal
EXW43_RS07100	COG1686	Belongs to the peptidase S11 family
EXW43_RS07105	COG0681	Belongs to the peptidase S26 family
EXW43_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS07150	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW43_RS07155	COG1177	transmembrane transport
EXW43_RS07160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW43_RS07170	COG2409	Drug exporters of the RND superfamily
EXW43_RS07180	COG0564	pseudouridine synthase activity
EXW43_RS07190	COG2340	Cysteine-rich secretory protein family
EXW43_RS07195	COG0247	lactate metabolic process
EXW43_RS07200	COG0277	FAD linked oxidase domain protein
EXW43_RS07205	COG3835	regulator
EXW43_RS07215	COG0745	RESPONSE REGULATOR receiver
EXW43_RS07220	COG5002	protein histidine kinase activity
EXW43_RS07225	COG2186	Transcriptional regulator
EXW43_RS07230	COG0247	lactate metabolic process
EXW43_RS07235	COG1139	Iron-sulfur cluster binding protein
EXW43_RS07240	COG1556	Lactate utilization protein
EXW43_RS07245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW43_RS07260	COG2211	Major facilitator Superfamily
EXW43_RS07275	COG4974	Belongs to the 'phage' integrase family
EXW43_RS07285	COG2116	formate transmembrane transporter activity
EXW43_RS07290	COG0861	Integral membrane protein TerC family
EXW43_RS07295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW43_RS07305	COG2030	dehydratase
EXW43_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS07330	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW43_RS07340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW43_RS07355	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW43_RS07360	COG3842	ATPase activity
EXW43_RS07370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW43_RS07375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW43_RS07385	COG1349	DNA-binding transcription factor activity
EXW43_RS07395	COG0235	Class ii aldolase
EXW43_RS07405	COG2861	carbohydrate metabolic process
EXW43_RS07415	COG3852	Histidine kinase
EXW43_RS07420	COG1846	Transcriptional regulator
EXW43_RS07430	COG2318	DinB family
EXW43_RS07435	COG5002	protein histidine kinase activity
EXW43_RS07440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW43_RS07445	COG0720	synthase
EXW43_RS07455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW43_RS07460	COG4873	Protein conserved in bacteria
EXW43_RS07475	COG0456	acetyltransferase
EXW43_RS07490	COG1780	Probably involved in ribonucleotide reductase function
EXW43_RS07505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW43_RS07510	COG0531	amino acid
EXW43_RS07515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW43_RS07530	COG2204	response regulator
EXW43_RS07535	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS07545	COG1725	Transcriptional regulator
EXW43_RS07550	COG1131	(ABC) transporter
EXW43_RS07560	COG1131	(ABC) transporter
EXW43_RS07565	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW43_RS07570	COG1266	CAAX protease self-immunity
EXW43_RS07580	COG1522	sequence-specific DNA binding
EXW43_RS07590	COG1335	isochorismatase
EXW43_RS07600	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW43_RS07605	COG2070	2-Nitropropane dioxygenase
EXW43_RS07610	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW43_RS07615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW43_RS07620	COG1696	Membrane protein involved in D-alanine export
EXW43_RS07645	COG0716	FMN binding
EXW43_RS07680	COG0534	Mate efflux family protein
EXW43_RS07685	COG1968	undecaprenyl-diphosphatase activity
EXW43_RS07705	COG1846	Transcriptional regulator
EXW43_RS07715	COG1301	dicarboxylic acid transport
EXW43_RS07720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW43_RS07730	COG3874	Sporulation protein YtfJ
EXW43_RS07755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS07760	COG0028	Belongs to the TPP enzyme family
EXW43_RS07765	COG0440	acetolactate synthase activity
EXW43_RS07775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW43_RS07785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW43_RS07795	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW43_RS07800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW43_RS07810	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW43_RS07815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW43_RS07820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW43_RS07825	COG0107	imidazoleglycerol-phosphate synthase activity
EXW43_RS07835	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW43_RS07840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW43_RS07855	COG1183	phosphatidylcholine synthase activity
EXW43_RS07860	COG1368	sulfuric ester hydrolase activity
EXW43_RS07870	COG0019	diaminopimelate decarboxylase activity
EXW43_RS07880	COG0175	sulfate reduction
EXW43_RS07885	COG2046	Belongs to the sulfate adenylyltransferase family
EXW43_RS07890	COG0529	Catalyzes the synthesis of activated sulfate
EXW43_RS07895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW43_RS07915	COG1648	precorrin-2 dehydrogenase activity
EXW43_RS07920	COG0733	neurotransmitter:sodium symporter activity
EXW43_RS07945	COG1757	Na H antiporter
EXW43_RS07960	COG4758	membrane
EXW43_RS07965	COG4585	Histidine kinase
EXW43_RS07970	COG2197	response regulator
EXW43_RS07980	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS07990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW43_RS08030	COG0730	response to heat
EXW43_RS08035	COG0306	phosphate transporter
EXW43_RS08040	COG1392	Phosphate transport regulator
EXW43_RS08045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS08060	COG3852	Histidine kinase
EXW43_RS08065	COG1801	Protein of unknown function DUF72
EXW43_RS08075	COG0582	viral genome integration into host DNA
EXW43_RS08080	COG5002	protein histidine kinase activity
EXW43_RS08095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW43_RS08095	COG0392	lysyltransferase activity
EXW43_RS08110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW43_RS08115	COG1686	Belongs to the peptidase S11 family
EXW43_RS08120	COG2715	membrane protein required for spore maturation
EXW43_RS08125	COG0700	Nucleoside recognition
EXW43_RS08130	COG1187	pseudouridine synthase activity
EXW43_RS08140	COG1333	cytochrome c biogenesis protein
EXW43_RS08145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW43_RS08150	COG0745	RESPONSE REGULATOR receiver
EXW43_RS08155	COG5002	protein histidine kinase activity
EXW43_RS08160	COG2096	Adenosyltransferase
EXW43_RS08165	COG4942	peptidase
EXW43_RS08175	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW43_RS08180	COG1141	Ferredoxin
EXW43_RS08185	COG4955	Helix-turn-helix domain
EXW43_RS08190	COG0514	ATP-dependent DNA helicase (RecQ)
EXW43_RS08195	COG1266	CAAX protease self-immunity
EXW43_RS08205	COG1408	metallophosphoesterase
EXW43_RS08220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW43_RS08240	COG0492	ferredoxin-NADP+ reductase activity
EXW43_RS08245	COG0252	asparaginase activity
EXW43_RS08255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW43_RS08265	COG1304	FMN binding
EXW43_RS08295	COG1160	GTP binding
EXW43_RS08300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW43_RS08320	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW43_RS08330	COG0302	gtp cyclohydrolase
EXW43_RS08335	COG0142	geranyltranstransferase activity
EXW43_RS08340	COG2226	methyltransferase
EXW43_RS08345	COG0142	geranyltranstransferase activity
EXW43_RS08360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW43_RS08370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW43_RS08375	COG0457	Tetratricopeptide repeat
EXW43_RS08380	COG5582	Belongs to the UPF0302 family
EXW43_RS08395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW43_RS08410	COG4347	Protein of unknown function (DUF1405)
EXW43_RS08425	COG2738	Putative neutral zinc metallopeptidase
EXW43_RS08435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS08440	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW43_RS08445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW43_RS08450	COG1803	Methylglyoxal synthase
EXW43_RS08455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW43_RS08460	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS08465	COG0617	tRNA 3'-terminal CCA addition
EXW43_RS08475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW43_RS08480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW43_RS08490	COG1199	ATP-dependent helicase activity
EXW43_RS08490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW43_RS08510	COG3935	DnaD domain protein
EXW43_RS08515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW43_RS08525	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW43_RS08525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS08530	COG3331	DNA recombination
EXW43_RS08565	COG4474	Belongs to the UPF0398 family
EXW43_RS08570	COG3599	regulation of cell shape
EXW43_RS08580	COG0116	Belongs to the methyltransferase superfamily
EXW43_RS08590	COG1199	ATP-dependent helicase activity
EXW43_RS08595	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW43_RS08605	COG0024	Methionine aminopeptidase
EXW43_RS08615	COG2233	PERMEase
EXW43_RS08620	COG2311	Membrane
EXW43_RS08630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW43_RS08640	COG0456	acetyltransferase
EXW43_RS08650	COG2897	thiosulfate sulfurtransferase activity
EXW43_RS08690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW43_RS08715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW43_RS08730	COG1215	transferase activity, transferring glycosyl groups
EXW43_RS08735	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS08750	COG0454	-acetyltransferase
EXW43_RS08770	COG0328	RNA-DNA hybrid ribonuclease activity
EXW43_RS08805	COG3403	YqcI/YcgG family
EXW43_RS08810	COG1280	lysine exporter protein (LysE YggA)
EXW43_RS08825	COG3162	membrane
EXW43_RS08830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW43_RS08835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW43_RS08845	COG0475	glutathione-regulated potassium exporter activity
EXW43_RS08850	COG4978	Transcriptional regulator
EXW43_RS08850	COG0789	Transcriptional regulator
EXW43_RS08860	COG2323	membrane
EXW43_RS08865	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW43_RS08895	COG2814	Major facilitator Superfamily
EXW43_RS08915	COG1923	regulation of RNA biosynthetic process
EXW43_RS08940	COG0835	chemotaxis
EXW43_RS08940	COG0784	Response regulator, receiver
EXW43_RS08970	COG0861	Integral membrane protein TerC family
EXW43_RS08980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW43_RS08995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW43_RS09000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW43_RS09000	COG1776	CheC inhibitor of MCP methylation
EXW43_RS09010	COG1338	Plays a role in the flagellum-specific transport system
EXW43_RS09015	COG1987	bacterial-type flagellum assembly
EXW43_RS09025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW43_RS09040	COG1419	protein localization to endoplasmic reticulum
EXW43_RS09045	COG4786	Flagellar basal body rod
EXW43_RS09080	COG0412	Dienelactone hydrolase
EXW43_RS09085	COG2329	Antibiotic biosynthesis monooxygenase
EXW43_RS09100	COG2814	Major facilitator Superfamily
EXW43_RS09110	COG0583	DNA-binding transcription factor activity
EXW43_RS09115	COG3842	ATPase activity
EXW43_RS09165	COG0406	alpha-ribazole phosphatase activity
EXW43_RS09195	COG0367	asparagine synthase
EXW43_RS09225	COG1802	Transcriptional regulator
EXW43_RS09230	COG0697	spore germination
EXW43_RS09240	COG1216	Glycosyl transferase, family 2
EXW43_RS09240	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS09245	COG1757	Na H antiporter
EXW43_RS09255	COG0277	FAD linked oxidase domain protein
EXW43_RS09275	COG0534	Mate efflux family protein
EXW43_RS09280	COG3340	Belongs to the peptidase S51 family
EXW43_RS09300	COG0785	Cytochrome C biogenesis protein
EXW43_RS09305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS09320	COG3048	D-serine ammonia-lyase activity
EXW43_RS09325	COG2733	membrane
EXW43_RS09360	COG1131	(ABC) transporter
EXW43_RS09375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW43_RS09410	COG0528	UMP kinase activity
EXW43_RS09420	COG1027	Aspartate ammonia-lyase
EXW43_RS09425	COG0281	malic enzyme
EXW43_RS09430	COG4191	Histidine kinase
EXW43_RS09435	COG0784	Response regulator, receiver
EXW43_RS09440	COG1846	Transcriptional regulator
EXW43_RS09450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW43_RS09460	COG2502	aspartate--ammonia ligase
EXW43_RS09495	COG1051	belongs to the nudix hydrolase family
EXW43_RS09500	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS09510	COG2814	Major facilitator Superfamily
EXW43_RS09540	COG0477	Major facilitator Superfamily
EXW43_RS09545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS09555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW43_RS09560	COG2223	nitrite transmembrane transporter activity
EXW43_RS09565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW43_RS09580	COG2244	polysaccharide biosynthetic process
EXW43_RS09585	COG0733	neurotransmitter:sodium symporter activity
EXW43_RS09595	COG5566	PFAM Mor transcription activator
EXW43_RS09600	COG2323	membrane
EXW43_RS09615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW43_RS09625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS09630	COG0028	Belongs to the TPP enzyme family
EXW43_RS09645	COG0129	dihydroxy-acid dehydratase activity
EXW43_RS09650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW43_RS09675	COG2814	Major facilitator Superfamily
EXW43_RS09680	COG3384	dioxygenase
EXW43_RS09705	COG4166	transmembrane transport
EXW43_RS09710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS09720	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW43_RS09725	COG1054	Belongs to the UPF0176 family
EXW43_RS09735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW43_RS09740	COG0531	amino acid
EXW43_RS09775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW43_RS09790	COG4257	antibiotic catabolic process
EXW43_RS09795	COG2390	Transcriptional regulator
EXW43_RS09805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW43_RS09810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS09815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW43_RS09830	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW43_RS09845	COG0583	DNA-binding transcription factor activity
EXW43_RS09865	COG0006	proline dipeptidase activity
EXW43_RS09870	COG2132	Multicopper oxidase
EXW43_RS09880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW43_RS09900	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS09910	COG2372	response to copper ion
EXW43_RS09910	COG1276	copper resistance
EXW43_RS09915	COG4549	nuclear export factor GLE1
EXW43_RS09925	COG0697	spore germination
EXW43_RS09930	COG0583	DNA-binding transcription factor activity
EXW43_RS09935	COG1959	2 iron, 2 sulfur cluster binding
EXW43_RS09940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW43_RS09945	COG0778	Nitroreductase
EXW43_RS09960	COG0628	permease
EXW43_RS09975	COG1231	oxidoreductase activity
EXW43_RS09980	COG0523	cobalamin synthesis protein
EXW43_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS09995	COG2030	dehydratase
EXW43_RS10000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS10015	COG0411	ABC transporter
EXW43_RS10035	COG0583	DNA-binding transcription factor activity
EXW43_RS10045	COG1942	4-Oxalocrotonate Tautomerase
EXW43_RS10060	COG0346	lactoylglutathione lyase activity
EXW43_RS10070	COG1271	oxidase subunit
EXW43_RS10075	COG1294	oxidase, subunit
EXW43_RS10080	COG4988	ABC transporter
EXW43_RS10085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW43_RS10115	COG1686	Belongs to the peptidase S11 family
EXW43_RS10130	COG1388	LysM domain
EXW43_RS10130	COG0791	NLP P60 protein
EXW43_RS10140	COG1132	(ABC) transporter
EXW43_RS10145	COG0745	RESPONSE REGULATOR receiver
EXW43_RS10150	COG5002	protein histidine kinase activity
EXW43_RS10155	COG0300	oxidoreductase activity
EXW43_RS10160	COG4122	O-methyltransferase activity
EXW43_RS10190	COG0460	homoserine dehydrogenase
EXW43_RS10200	COG0083	homoserine kinase activity
EXW43_RS10215	COG1316	TRANSCRIPTIONal
EXW43_RS10235	COG1285	pathogenesis
EXW43_RS10240	COG1247	-acetyltransferase
EXW43_RS10260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW43_RS10270	COG1082	Xylose isomerase domain protein TIM barrel
EXW43_RS10280	COG2814	Major facilitator Superfamily
EXW43_RS10285	COG1279	arginine transmembrane transporter activity
EXW43_RS10290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS10300	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW43_RS10330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW43_RS10335	COG0577	efflux transmembrane transporter activity
EXW43_RS10340	COG2002	toxin-antitoxin pair type II binding
EXW43_RS10345	COG1404	Belongs to the peptidase S8 family
EXW43_RS10350	COG0640	Transcriptional regulator
EXW43_RS10355	COG0667	Aldo Keto reductase
EXW43_RS10400	COG3949	Membrane
EXW43_RS10405	COG0783	Belongs to the Dps family
EXW43_RS10420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW43_RS10430	COG1231	oxidoreductase activity
EXW43_RS10435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS10440	COG4989	oxidoreductase activity
EXW43_RS10445	COG0523	cobalamin synthesis protein
EXW43_RS10450	COG0456	acetyltransferase
EXW43_RS10455	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW43_RS10480	COG1136	(ABC) transporter
EXW43_RS10485	COG0577	efflux transmembrane transporter activity
EXW43_RS10490	COG0745	RESPONSE REGULATOR receiver
EXW43_RS10495	COG2205	protein histidine kinase activity
EXW43_RS10500	COG1902	pentaerythritol trinitrate reductase activity
EXW43_RS10505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW43_RS10515	COG4166	transmembrane transport
EXW43_RS10520	COG0346	lactoylglutathione lyase activity
EXW43_RS10530	COG0406	alpha-ribazole phosphatase activity
EXW43_RS10540	COG5337	Spore coat protein CotH
EXW43_RS10545	COG1051	belongs to the nudix hydrolase family
EXW43_RS10550	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS10555	COG2244	polysaccharide biosynthetic process
EXW43_RS10565	COG0701	Predicted permease
EXW43_RS10570	COG3689	TIGRFAM TIGR03943 family protein
EXW43_RS10575	COG1607	acyl-coa hydrolase
EXW43_RS10585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW43_RS10600	COG0702	epimerase
EXW43_RS10605	COG2839	Protein conserved in bacteria
EXW43_RS10610	COG1253	flavin adenine dinucleotide binding
EXW43_RS10635	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS10640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW43_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS10665	COG1876	peptidase activity
EXW43_RS10680	COG2211	Major facilitator Superfamily
EXW43_RS10695	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS10705	COG0561	phosphatase activity
EXW43_RS10715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW43_RS10730	COG1819	glycosyl
EXW43_RS10735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS10740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS10765	COG0456	acetyltransferase
EXW43_RS10800	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW43_RS10925	COG3874	Sporulation protein YtfJ
EXW43_RS10950	COG2226	methyltransferase
EXW43_RS10980	COG0604	alcohol dehydrogenase
EXW43_RS10985	COG1595	DNA-templated transcription, initiation
EXW43_RS11010	COG0426	domain, Protein
EXW43_RS11010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW43_RS11020	COG0386	Belongs to the glutathione peroxidase family
EXW43_RS11025	COG1305	Transglutaminase-like
EXW43_RS11030	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW43_RS11035	COG0714	Associated with various cellular activities
EXW43_RS11040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW43_RS11045	COG1140	nitrate reductase beta subunit
EXW43_RS11050	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW43_RS11055	COG2181	nitrate reductase activity
EXW43_RS11060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW43_RS11065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW43_RS11070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW43_RS11075	COG0303	'Molybdopterin
EXW43_RS11080	COG0314	molybdopterin synthase activity
EXW43_RS11090	COG2223	nitrite transmembrane transporter activity
EXW43_RS11115	COG1648	precorrin-2 dehydrogenase activity
EXW43_RS11125	COG1587	Uroporphyrinogen-III synthase
EXW43_RS11125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW43_RS11130	COG2146	nitrite reductase [NAD(P)H] activity
EXW43_RS11135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW43_RS11140	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW43_RS11170	COG2359	stage V sporulation protein S
EXW43_RS11180	COG1418	mRNA catabolic process
EXW43_RS11185	COG0488	(ABC) transporter
EXW43_RS11205	COG1413	lyase activity
EXW43_RS11220	COG2521	methyltransferase
EXW43_RS11220	COG2136	Putative SAM-dependent methyltransferase
EXW43_RS11275	COG0017	Asparaginyl-tRNA synthetase
EXW43_RS11280	COG0733	neurotransmitter:sodium symporter activity
EXW43_RS11305	COG2610	gluconate transmembrane transporter activity
EXW43_RS11315	COG1794	racemase activity, acting on amino acids and derivatives
EXW43_RS11325	COG0456	acetyltransferase
EXW43_RS11330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW43_RS11340	COG1131	(ABC) transporter
EXW43_RS11345	COG4473	ABC transporter
EXW43_RS11355	COG0546	phosphoglycolate phosphatase activity
EXW43_RS11370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW43_RS11385	COG0768	penicillin binding
EXW43_RS11395	COG0204	Acyl-transferase
EXW43_RS11400	COG1272	protein, Hemolysin III
EXW43_RS11405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW43_RS11410	COG0805	protein transport
EXW43_RS11425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW43_RS11430	COG1999	signal sequence binding
EXW43_RS11435	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW43_RS11440	COG0367	asparagine synthase
EXW43_RS11455	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS11460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS11465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS11485	COG1335	isochorismatase
EXW43_RS11495	COG0668	transmembrane transport
EXW43_RS11500	COG2203	Gaf domain
EXW43_RS11500	COG4585	Histidine kinase
EXW43_RS11505	COG2197	response regulator
EXW43_RS11510	COG1737	Transcriptional regulator
EXW43_RS11515	COG1064	alcohol dehydrogenase
EXW43_RS11530	COG1070	Carbohydrate kinase
EXW43_RS11540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW43_RS11560	COG1125	glycine betaine transport
EXW43_RS11560	COG0517	IMP dehydrogenase activity
EXW43_RS11565	COG1174	glycine betaine transport
EXW43_RS11600	COG1253	flavin adenine dinucleotide binding
EXW43_RS11605	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS11610	COG5506	Protein of unknown function (DUF1694)
EXW43_RS11625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW43_RS11630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW43_RS11635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW43_RS11640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW43_RS11645	COG0456	acetyltransferase
EXW43_RS11650	COG3829	transcription factor binding
EXW43_RS11655	COG1509	lysine 2,3-aminomutase activity
EXW43_RS11665	COG4479	Belongs to the UPF0346 family
EXW43_RS11690	COG0515	serine threonine protein kinase
EXW43_RS11690	COG3064	Membrane
EXW43_RS11690	COG4991	sh3 domain protein
EXW43_RS11700	COG0671	phosphoesterase, PA-phosphatase related
EXW43_RS11705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW43_RS11710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS11765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW43_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS11815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS11815	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW43_RS11825	COG2814	Major facilitator Superfamily
EXW43_RS11835	COG0372	Belongs to the citrate synthase family
EXW43_RS11840	COG2079	MmgE PrpD family protein
EXW43_RS11845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW43_RS11850	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS11855	COG2084	Dehydrogenase
EXW43_RS11860	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS11865	COG1280	lysine exporter protein (LysE YggA)
EXW43_RS11870	COG1024	Enoyl-CoA hydratase
EXW43_RS11885	COG0420	3'-5' exonuclease activity
EXW43_RS11910	COG2223	nitrite transmembrane transporter activity
EXW43_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS11920	COG1169	isochorismate synthase
EXW43_RS11925	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW43_RS11930	COG1535	isochorismatase
EXW43_RS11930	COG3433	isochorismatase activity
EXW43_RS11935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW43_RS11940	COG3251	PFAM MbtH domain protein
EXW43_RS11945	COG2814	Major facilitator Superfamily
EXW43_RS11960	COG0776	regulation of translation
EXW43_RS11970	COG2318	DinB family
EXW43_RS11975	COG1115	amino acid carrier protein
EXW43_RS11990	COG2329	Antibiotic biosynthesis monooxygenase
EXW43_RS12000	COG1187	pseudouridine synthase activity
EXW43_RS12005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW43_RS12010	COG3655	Transcriptional regulator
EXW43_RS12020	COG1136	(ABC) transporter
EXW43_RS12030	COG0596	Alpha beta hydrolase
EXW43_RS12050	COG0028	Belongs to the TPP enzyme family
EXW43_RS12075	COG1253	flavin adenine dinucleotide binding
EXW43_RS12105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW43_RS12125	COG1846	Transcriptional regulator
EXW43_RS12135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS12140	COG1309	transcriptional regulator
EXW43_RS12170	COG1247	-acetyltransferase
EXW43_RS12200	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW43_RS12210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS12240	COG0583	DNA-binding transcription factor activity
EXW43_RS12245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW43_RS12260	COG0583	DNA-binding transcription factor activity
EXW43_RS12265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW43_RS12270	COG2258	MOSC domain
EXW43_RS12285	COG1132	(ABC) transporter
EXW43_RS12290	COG1132	(ABC) transporter
EXW43_RS12330	COG1396	sequence-specific DNA binding
EXW43_RS12360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW43_RS12370	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW43_RS12375	COG1595	DNA-templated transcription, initiation
EXW43_RS12470	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW43_RS12475	COG2971	BadF BadG BcrA BcrD
EXW43_RS12485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW43_RS12575	COG3645	SOS response
EXW43_RS12575	COG3646	Phage regulatory protein
EXW43_RS12630	COG0582	viral genome integration into host DNA
EXW43_RS12650	COG1136	(ABC) transporter
EXW43_RS12655	COG0500	methyltransferase
EXW43_RS12655	COG3615	Tellurite resistance protein tehB
EXW43_RS12665	COG0693	protein deglycase activity
EXW43_RS12675	COG0588	phosphoglycerate mutase activity
EXW43_RS12700	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW43_RS12710	COG0110	maltose O-acetyltransferase activity
EXW43_RS12715	COG1136	(ABC) transporter
EXW43_RS12740	COG1686	Belongs to the peptidase S11 family
EXW43_RS12765	COG0768	penicillin binding
EXW43_RS12770	COG0745	RESPONSE REGULATOR receiver
EXW43_RS12775	COG2205	protein histidine kinase activity
EXW43_RS12780	COG1136	(ABC) transporter
EXW43_RS12785	COG0577	efflux transmembrane transporter activity
EXW43_RS12795	COG1595	DNA-templated transcription, initiation
EXW43_RS12805	COG0768	penicillin binding
EXW43_RS12810	COG0768	penicillin binding
EXW43_RS12830	COG1252	NADH dehydrogenase
EXW43_RS12835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS12835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS12850	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW43_RS12850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS12870	COG1136	(ABC) transporter
EXW43_RS12875	COG0577	efflux transmembrane transporter activity
EXW43_RS12895	COG1136	(ABC) transporter
EXW43_RS12980	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS12990	COG2239	Acts as a magnesium transporter
EXW43_RS13020	COG0697	spore germination
EXW43_RS13045	COG3397	chitin binding
EXW43_RS13050	COG0823	Involved in the tonB-independent uptake of proteins
EXW43_RS13060	COG1408	metallophosphoesterase
EXW43_RS13070	COG1131	(ABC) transporter
EXW43_RS13080	COG1309	transcriptional regulator
EXW43_RS13090	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS13095	COG0439	Biotin carboxylase
EXW43_RS13100	COG0511	ligase activity, forming carbon-carbon bonds
EXW43_RS13105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW43_RS13110	COG1024	Enoyl-CoA hydratase
EXW43_RS13115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW43_RS13120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW43_RS13165	COG0572	uridine kinase
EXW43_RS13200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW43_RS13225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW43_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS13255	COG1733	regulation of RNA biosynthetic process
EXW43_RS13280	COG1309	transcriptional regulator
EXW43_RS13310	COG0697	spore germination
EXW43_RS13315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS13345	COG2323	membrane
EXW43_RS13360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS13365	COG0697	spore germination
EXW43_RS13385	COG0201	protein transport
EXW43_RS13395	COG0737	Belongs to the 5'-nucleotidase family
EXW43_RS13400	COG3227	Zinc metalloprotease (Elastase)
EXW43_RS13405	COG1523	belongs to the glycosyl hydrolase 13 family
EXW43_RS13420	COG0076	glutamate decarboxylase activity
EXW43_RS13425	COG0657	acetylesterase activity
EXW43_RS13440	COG0577	efflux transmembrane transporter activity
EXW43_RS13445	COG1136	(ABC) transporter
EXW43_RS13460	COG5002	protein histidine kinase activity
EXW43_RS13465	COG0745	RESPONSE REGULATOR receiver
EXW43_RS13470	COG1011	Hydrolase
EXW43_RS13495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW43_RS13500	COG1183	phosphatidylcholine synthase activity
EXW43_RS13510	COG1132	(ABC) transporter
EXW43_RS13535	COG0322	excinuclease ABC activity
EXW43_RS13560	COG2318	DinB family
EXW43_RS13575	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW43_RS13600	COG3878	Protein conserved in bacteria
EXW43_RS13625	COG1051	belongs to the nudix hydrolase family
EXW43_RS13630	COG0592	DNA-directed DNA polymerase activity
EXW43_RS13635	COG2816	NAD+ diphosphatase activity
EXW43_RS13645	COG2223	nitrite transmembrane transporter activity
EXW43_RS13655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW43_RS13665	COG0494	nUDIX hydrolase
EXW43_RS13685	COG0697	spore germination
EXW43_RS13690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS13705	COG0584	glycerophosphoryl diester phosphodiesterase
EXW43_RS13720	COG2814	Major facilitator Superfamily
EXW43_RS13760	COG0768	penicillin binding
EXW43_RS13765	COG0671	phosphoesterase, PA-phosphatase related
EXW43_RS13770	COG0604	alcohol dehydrogenase
EXW43_RS13775	COG5002	protein histidine kinase activity
EXW43_RS13780	COG0745	RESPONSE REGULATOR receiver
EXW43_RS13790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW43_RS13800	COG2205	protein histidine kinase activity
EXW43_RS13815	COG1122	ATPase activity
EXW43_RS13820	COG4720	Psort location CytoplasmicMembrane, score
EXW43_RS13825	COG1794	racemase activity, acting on amino acids and derivatives
EXW43_RS13830	COG1819	glycosyl
EXW43_RS13840	COG0768	penicillin binding
EXW43_RS13845	COG5002	protein histidine kinase activity
EXW43_RS13850	COG0561	phosphatase activity
EXW43_RS13895	COG2124	cytochrome p450
EXW43_RS13940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW43_RS13950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS13955	COG0460	homoserine dehydrogenase
EXW43_RS13975	COG0577	efflux transmembrane transporter activity
EXW43_RS13980	COG1136	(ABC) transporter
EXW43_RS13990	COG0488	(ABC) transporter
EXW43_RS13995	COG0667	Aldo Keto reductase
EXW43_RS14000	COG0583	DNA-binding transcription factor activity
EXW43_RS14005	COG2205	protein histidine kinase activity
EXW43_RS14010	COG0745	RESPONSE REGULATOR receiver
EXW43_RS14020	COG3773	Cell wall hydrolase
EXW43_RS14025	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW43_RS14035	COG3386	PFAM SMP-30 Gluconolaconase
EXW43_RS14075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS14090	COG2959	enzyme of heme biosynthesis
EXW43_RS14115	COG3483	tryptophan 2,3-dioxygenase activity
EXW43_RS14120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW43_RS14125	COG3844	kynureninase activity
EXW43_RS14130	COG1309	transcriptional regulator
EXW43_RS14145	COG3284	Transcriptional regulator
EXW43_RS14165	COG1349	DNA-binding transcription factor activity
EXW43_RS14185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW43_RS14190	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW43_RS14195	COG0022	dehydrogenase e1 component
EXW43_RS14200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW43_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS14225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW43_RS14225	COG0456	acetyltransferase
EXW43_RS14255	COG4176	ABC-type proline glycine betaine transport system permease component
EXW43_RS14260	COG0517	IMP dehydrogenase activity
EXW43_RS14260	COG4175	Glycine betaine
EXW43_RS14285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW43_RS14290	COG2153	protein acetylation
EXW43_RS14295	COG3397	chitin binding
EXW43_RS14305	COG1819	glycosyl
EXW43_RS14325	COG2205	protein histidine kinase activity
EXW43_RS14330	COG2226	methyltransferase
EXW43_RS14335	COG2315	Protein conserved in bacteria
EXW43_RS14395	COG3973	AAA domain
EXW43_RS14410	COG0514	ATP-dependent DNA helicase (RecQ)
EXW43_RS14435	COG4637	Psort location Cytoplasmic, score
EXW43_RS14445	COG1227	inorganic diphosphatase activity
EXW43_RS14450	COG3397	chitin binding
EXW43_RS14455	COG2318	DinB family
EXW43_RS14475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW43_RS14480	COG1115	amino acid carrier protein
EXW43_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS14490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW43_RS14500	COG3938	Belongs to the proline racemase family
EXW43_RS14505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW43_RS14545	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS14560	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW43_RS14565	COG4166	transmembrane transport
EXW43_RS14575	COG4948	Mandelate Racemase Muconate Lactonizing
EXW43_RS14595	COG0667	Aldo Keto reductase
EXW43_RS14635	COG2936	dipeptidyl-peptidase activity
EXW43_RS14645	COG0745	RESPONSE REGULATOR receiver
EXW43_RS14665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW43_RS14670	COG1164	Oligoendopeptidase f
EXW43_RS14685	COG1307	EDD domain protein, DegV family
EXW43_RS14710	COG1335	isochorismatase
EXW43_RS14725	COG2814	Major facilitator Superfamily
EXW43_RS14735	COG1664	Polymer-forming cytoskeletal
EXW43_RS14740	COG0789	Transcriptional regulator
EXW43_RS14745	COG4533	DNA binding
EXW43_RS14750	COG0477	Major facilitator Superfamily
EXW43_RS14750	COG2814	Major facilitator Superfamily
EXW43_RS14770	COG2261	transglycosylase associated protein
EXW43_RS14785	COG2226	methyltransferase
EXW43_RS14820	COG0436	Aminotransferase
EXW43_RS14825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW43_RS14855	COG1131	(ABC) transporter
EXW43_RS14860	COG2188	Transcriptional regulator
EXW43_RS14900	COG0628	permease
EXW43_RS14945	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW43_RS14955	COG0697	spore germination
EXW43_RS14960	COG2318	DinB family
EXW43_RS15010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW43_RS15020	COG2814	Major facilitator Superfamily
EXW43_RS15025	COG1368	sulfuric ester hydrolase activity
EXW43_RS15040	COG0488	(ABC) transporter
EXW43_RS15045	COG1033	growth of symbiont in host cell
EXW43_RS15045	COG2409	Drug exporters of the RND superfamily
EXW43_RS15050	COG1309	transcriptional regulator
EXW43_RS15070	COG0287	Prephenate dehydrogenase
EXW43_RS15085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW43_RS15085	COG1605	Chorismate mutase
EXW43_RS15120	COG3584	3D domain protein
EXW43_RS15120	COG1388	LysM domain
EXW43_RS15130	COG0346	lactoylglutathione lyase activity
EXW43_RS15140	COG0431	NADPH-dependent FMN reductase
EXW43_RS15165	COG0579	oxidoreductase
EXW43_RS15170	COG1879	ABC-type sugar transport system periplasmic component
EXW43_RS15180	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW43_RS15185	COG1129	ABC transporter
EXW43_RS15190	COG2390	Transcriptional regulator
EXW43_RS15210	COG2226	methyltransferase
EXW43_RS15230	COG2329	Antibiotic biosynthesis monooxygenase
EXW43_RS15260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS15265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW43_RS15270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW43_RS15275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW43_RS15280	COG3239	Fatty acid desaturase
EXW43_RS15305	COG3842	ATPase activity
EXW43_RS15330	COG1175	transmembrane transport
EXW43_RS15335	COG1349	DNA-binding transcription factor activity
EXW43_RS15345	COG3655	Transcriptional regulator
EXW43_RS15360	COG4377	Putative membrane peptidase family (DUF2324)
EXW43_RS15370	COG3279	Response regulator of the LytR AlgR family
EXW43_RS15385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS15390	COG0346	lactoylglutathione lyase activity
EXW43_RS15420	COG0714	Associated with various cellular activities
EXW43_RS15440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW43_RS15445	COG0753	catalase activity
EXW43_RS15455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW43_RS15475	COG0778	Nitroreductase
EXW43_RS15480	COG1846	Transcriptional regulator
EXW43_RS15500	COG3831	ATPase activity
EXW43_RS15500	COG4884	unkown
EXW43_RS15520	COG2207	Transcriptional regulator
EXW43_RS15525	COG0456	acetyltransferase
EXW43_RS15540	COG0697	spore germination
EXW43_RS15545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS15570	COG0814	amino acid
EXW43_RS15575	COG0697	spore germination
EXW43_RS15590	COG0642	Histidine kinase
EXW43_RS15595	COG0745	RESPONSE REGULATOR receiver
EXW43_RS15600	COG0596	Alpha beta hydrolase
EXW43_RS15610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW43_RS15610	COG0456	acetyltransferase
EXW43_RS15635	COG0730	response to heat
EXW43_RS15650	COG0833	amino acid
EXW43_RS15660	COG4335	DNA alkylation repair
EXW43_RS15685	COG0681	Belongs to the peptidase S26 family
EXW43_RS15690	COG0768	penicillin binding
EXW43_RS15705	COG3104	oligopeptide transport
EXW43_RS15710	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW43_RS15725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW43_RS15730	COG1984	allophanate hydrolase subunit 2
EXW43_RS15735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW43_RS15740	COG1414	Transcriptional regulator
EXW43_RS15750	COG3142	Participates in the control of copper homeostasis
EXW43_RS15755	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS15780	COG0640	Transcriptional regulator
EXW43_RS15790	COG3314	Sporulation integral membrane protein YlbJ
EXW43_RS15810	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW43_RS15815	COG0577	efflux transmembrane transporter activity
EXW43_RS15820	COG0577	efflux transmembrane transporter activity
EXW43_RS15825	COG1136	(ABC) transporter
EXW43_RS15860	COG3848	Pyruvate phosphate dikinase
EXW43_RS15860	COG0574	Belongs to the PEP-utilizing enzyme family
EXW43_RS15870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW43_RS15895	COG5002	protein histidine kinase activity
EXW43_RS15900	COG0745	RESPONSE REGULATOR receiver
EXW43_RS15910	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW43_RS15940	COG0798	PFAM Bile acid sodium symporter
EXW43_RS15945	COG0346	lactoylglutathione lyase activity
EXW43_RS15950	COG0640	Transcriptional regulator
EXW43_RS15990	COG1522	sequence-specific DNA binding
EXW43_RS16010	COG0346	lactoylglutathione lyase activity
EXW43_RS16035	COG0745	RESPONSE REGULATOR receiver
EXW43_RS16040	COG5002	protein histidine kinase activity
EXW43_RS16040	COG3850	Histidine kinase
EXW43_RS16070	COG1073	alpha beta
EXW43_RS16075	COG0814	amino acid
EXW43_RS16080	COG1760	l-serine dehydratase
EXW43_RS16085	COG1760	l-serine dehydratase
EXW43_RS16095	COG5002	protein histidine kinase activity
EXW43_RS16100	COG0745	RESPONSE REGULATOR receiver
EXW43_RS16110	COG5002	protein histidine kinase activity
EXW43_RS16135	COG4977	sequence-specific DNA binding
EXW43_RS16175	COG2814	Major facilitator Superfamily
EXW43_RS16190	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW43_RS16215	COG1522	sequence-specific DNA binding
EXW43_RS16225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW43_RS16240	COG1136	(ABC) transporter
EXW43_RS16245	COG0577	efflux transmembrane transporter activity
EXW43_RS16265	COG5002	protein histidine kinase activity
EXW43_RS16265	COG3850	Histidine kinase
EXW43_RS16275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS16295	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW43_RS16315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW43_RS16350	COG2814	Major facilitator Superfamily
EXW43_RS16385	COG5444	nuclease activity
EXW43_RS16425	COG0477	Major facilitator Superfamily
EXW43_RS16440	COG1846	Transcriptional regulator
EXW43_RS16445	COG2814	Major facilitator Superfamily
EXW43_RS16470	COG0640	Transcriptional regulator
EXW43_RS16495	COG1329	Transcriptional regulator
EXW43_RS16550	COG5002	protein histidine kinase activity
EXW43_RS16565	COG1136	(ABC) transporter
EXW43_RS16580	COG1131	(ABC) transporter
EXW43_RS16685	COG4187	Peptidase family M20/M25/M40
EXW43_RS16700	COG2031	fatty acid transporter
EXW43_RS16710	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW43_RS16760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW43_RS16765	COG1288	antiporter activity
EXW43_RS16770	COG2356	endonuclease I
EXW43_RS16775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW43_RS16795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW43_RS16815	COG1785	Belongs to the alkaline phosphatase family
EXW43_RS16820	COG0778	Nitroreductase
EXW43_RS16825	COG1733	regulation of RNA biosynthetic process
EXW43_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS16850	COG1131	(ABC) transporter
EXW43_RS16880	COG1011	Hydrolase
EXW43_RS16885	COG2365	Tyrosine phosphatase family
EXW43_RS16910	COG0346	lactoylglutathione lyase activity
EXW43_RS16915	COG1940	carbohydrate kinase activity
EXW43_RS16920	COG0738	Major facilitator superfamily
EXW43_RS16925	COG0110	maltose O-acetyltransferase activity
EXW43_RS16940	COG0628	permease
EXW43_RS16945	COG2261	transglycosylase associated protein
EXW43_RS16960	COG1720	tRNA m6t6A37 methyltransferase activity
EXW43_RS16965	COG0500	methyltransferase
EXW43_RS16975	COG0477	Major facilitator Superfamily
EXW43_RS16990	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW43_RS17000	COG1253	flavin adenine dinucleotide binding
EXW43_RS17005	COG0789	Transcriptional regulator
EXW43_RS17015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW43_RS17040	COG0697	spore germination
EXW43_RS17050	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW43_RS17055	COG3813	Protein conserved in bacteria
EXW43_RS17060	COG2706	6-phosphogluconolactonase activity
EXW43_RS17065	COG1070	Carbohydrate kinase
EXW43_RS17075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW43_RS17080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW43_RS17095	COG0814	amino acid
EXW43_RS17115	COG1393	Belongs to the ArsC family
EXW43_RS17125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS17140	COG0494	nUDIX hydrolase
EXW43_RS17155	COG0384	phenazine biosynthesis protein PhzF
EXW43_RS17165	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS17170	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW43_RS17175	COG1733	regulation of RNA biosynthetic process
EXW43_RS17190	COG1191	sigma factor activity
EXW43_RS17205	COG1876	peptidase activity
EXW43_RS17250	COG0741	lytic transglycosylase activity
EXW43_RS17270	COG2197	response regulator
EXW43_RS17275	COG4585	Histidine kinase
EXW43_RS17320	COG5002	protein histidine kinase activity
EXW43_RS17325	COG0745	RESPONSE REGULATOR receiver
EXW43_RS17360	COG0814	amino acid
EXW43_RS17385	COG1151	hydroxylamine reductase activity
EXW43_RS17410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW43_RS17420	COG2072	flavoprotein involved in K transport
EXW43_RS17460	COG0604	alcohol dehydrogenase
EXW43_RS17465	COG1113	amino acid transport
EXW43_RS17475	COG2814	Major facilitator Superfamily
EXW43_RS17485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW43_RS17490	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS17500	COG0534	Mate efflux family protein
EXW43_RS17505	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS17510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW43_RS17525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW43_RS17530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW43_RS17550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS17555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS17560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS17565	COG3739	integral membrane protein
EXW43_RS17585	COG0583	DNA-binding transcription factor activity
EXW43_RS17610	COG1193	negative regulation of DNA recombination
EXW43_RS17630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW43_RS17635	COG1164	Oligoendopeptidase f
EXW43_RS17640	COG2957	Belongs to the agmatine deiminase family
EXW43_RS17660	COG3781	membrane
EXW43_RS17675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW43_RS17710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW43_RS17715	COG0640	Transcriptional regulator
EXW43_RS17720	COG0604	alcohol dehydrogenase
EXW43_RS17725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW43_RS17730	COG0457	Tetratricopeptide repeat
EXW43_RS17740	COG2808	Putative FMN-binding domain
EXW43_RS17745	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW43_RS17755	COG0277	FAD linked oxidase domain protein
EXW43_RS17775	COG1285	pathogenesis
EXW43_RS17785	COG2514	catechol 2,3-dioxygenase activity
EXW43_RS17790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS17795	COG1126	abc transporter atp-binding protein
EXW43_RS17800	COG0765	amino acid transport
EXW43_RS17805	COG2720	vancomycin resistance protein
EXW43_RS17830	COG1278	Cold shock
EXW43_RS17840	COG0716	FMN binding
EXW43_RS17850	COG0494	nUDIX hydrolase
EXW43_RS17870	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS17880	COG0165	Argininosuccinate lyase
EXW43_RS17895	COG4145	pantothenate transmembrane transporter activity
EXW43_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS17910	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS17920	COG1657	PFAM Prenyltransferase squalene oxidase
EXW43_RS17925	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW43_RS17930	COG2962	Rard protein
EXW43_RS17935	COG3326	Membrane
EXW43_RS17940	COG0531	amino acid
EXW43_RS17975	COG2226	methyltransferase
EXW43_RS17980	COG4166	transmembrane transport
EXW43_RS17985	COG4166	transmembrane transport
EXW43_RS17990	COG4166	transmembrane transport
EXW43_RS17995	COG1316	TRANSCRIPTIONal
EXW43_RS18005	COG1595	DNA-templated transcription, initiation
EXW43_RS18015	COG1131	(ABC) transporter
EXW43_RS18035	COG0673	inositol 2-dehydrogenase activity
EXW43_RS18040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW43_RS18045	COG0187	DNA topoisomerase II activity
EXW43_RS18050	COG1832	CoA-binding protein
EXW43_RS18055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW43_RS18060	COG0745	RESPONSE REGULATOR receiver
EXW43_RS18070	COG1328	CTP reductase activity
EXW43_RS18080	COG4841	protein insertion into membrane
EXW43_RS18085	COG0824	Thioesterase
EXW43_RS18110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS18125	COG1132	(ABC) transporter
EXW43_RS18130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW43_RS18160	COG2211	Major facilitator Superfamily
EXW43_RS18170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW43_RS18185	COG0183	Belongs to the thiolase family
EXW43_RS18190	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS18195	COG1268	BioY protein
EXW43_RS18200	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS18205	COG1396	sequence-specific DNA binding
EXW43_RS18225	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EXW43_RS18245	COG0830	nickel cation binding
EXW43_RS18285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS18295	COG5002	protein histidine kinase activity
EXW43_RS18305	COG0400	carboxylic ester hydrolase activity
EXW43_RS18310	COG0346	lactoylglutathione lyase activity
EXW43_RS18315	COG0069	glutamate synthase activity
EXW43_RS18320	COG1902	pentaerythritol trinitrate reductase activity
EXW43_RS18330	COG1329	Transcriptional regulator
EXW43_RS18335	COG0010	Belongs to the arginase family
EXW43_RS18345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW43_RS18350	COG2986	histidine ammonia-lyase
EXW43_RS18360	COG2226	methyltransferase
EXW43_RS18385	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW43_RS18390	COG0785	Cytochrome C biogenesis protein
EXW43_RS18405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW43_RS18410	COG1131	(ABC) transporter
EXW43_RS18420	COG0583	DNA-binding transcription factor activity
EXW43_RS18430	COG1346	cytolysis
EXW43_RS18445	COG0730	response to heat
EXW43_RS18455	COG3409	Peptidoglycan-binding domain 1 protein
EXW43_RS18455	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS18475	COG1132	(ABC) transporter
EXW43_RS18480	COG1132	(ABC) transporter
EXW43_RS18485	COG3763	UPF0154 protein
EXW43_RS18505	COG3639	organic phosphonate transmembrane transporter activity
EXW43_RS18515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS18520	COG0737	Belongs to the 5'-nucleotidase family
EXW43_RS18530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW43_RS18535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW43_RS18550	COG1695	Transcriptional regulator
EXW43_RS18555	COG0174	glutamine synthetase
EXW43_RS18560	COG0789	Transcriptional regulator
EXW43_RS18565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW43_RS18570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW43_RS18575	COG2860	membrane
EXW43_RS18585	COG0464	growth
EXW43_RS18605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW43_RS18615	COG3584	3D domain protein
EXW43_RS18615	COG1388	LysM domain
EXW43_RS18620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW43_RS18620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW43_RS18620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW43_RS18625	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW43_RS18630	COG1349	DNA-binding transcription factor activity
EXW43_RS18635	COG1979	alcohol dehydrogenase
EXW43_RS18640	COG2322	membrane
EXW43_RS18650	COG1113	amino acid transport
EXW43_RS18665	COG1408	metallophosphoesterase
EXW43_RS18670	COG2116	formate transmembrane transporter activity
EXW43_RS18685	COG2217	Heavy metal translocating P-type atpase
EXW43_RS18690	COG2608	mercury ion transmembrane transporter activity
EXW43_RS18695	COG1937	Protein conserved in bacteria
EXW43_RS18725	COG4566	intracellular signal transduction
EXW43_RS18730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW43_RS18735	COG2819	hydrolase of the alpha beta superfamily
EXW43_RS18740	COG1120	ATPase activity
EXW43_RS18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS18750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS18755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS18760	COG0708	Exodeoxyribonuclease III
EXW43_RS18765	COG2169	Transcriptional regulator
EXW43_RS18770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW43_RS18775	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW43_RS18780	COG2706	6-phosphogluconolactonase activity
EXW43_RS18785	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW43_RS18790	COG2364	Membrane
EXW43_RS18800	COG0346	lactoylglutathione lyase activity
EXW43_RS18805	COG5001	Diguanylate cyclase
EXW43_RS18805	COG3300	MHYT domain
EXW43_RS18845	COG1346	cytolysis
EXW43_RS18855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW43_RS18860	COG0596	Alpha beta hydrolase
EXW43_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW43_RS18865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW43_RS18875	COG2188	Transcriptional regulator
EXW43_RS18880	COG2723	6-phospho-beta-galactosidase activity
EXW43_RS18885	COG0823	Involved in the tonB-independent uptake of proteins
EXW43_RS18890	COG3773	Cell wall hydrolase
EXW43_RS18900	COG1368	sulfuric ester hydrolase activity
EXW43_RS18905	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW43_RS18915	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW43_RS18920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW43_RS18925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW43_RS18935	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW43_RS18940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW43_RS18945	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW43_RS18950	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW43_RS18950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW43_RS18960	COG2359	stage V sporulation protein S
EXW43_RS18965	COG1692	metallophosphoesterase
EXW43_RS18970	COG1418	mRNA catabolic process
EXW43_RS18975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW43_RS18980	COG1058	Belongs to the CinA family
EXW43_RS18980	COG1546	Belongs to the CinA family
EXW43_RS18985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW43_RS18990	COG1426	Protein conserved in bacteria
EXW43_RS19005	COG0300	oxidoreductase activity
EXW43_RS19010	COG0612	Peptidase, M16
EXW43_RS19015	COG0612	Peptidase, M16
EXW43_RS19020	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW43_RS19025	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW43_RS19030	COG3845	ABC transporter
EXW43_RS19035	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW43_RS19040	COG2188	Transcriptional regulator
EXW43_RS19050	COG1674	ftsk spoiiie
EXW43_RS19060	COG0740	serine-type endopeptidase activity
EXW43_RS19065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW43_RS19075	COG0527	aspartate kinase activity
EXW43_RS19080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW43_RS19085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW43_RS19090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW43_RS19095	COG1873	PFAM PRC-barrel domain
EXW43_RS19100	COG0612	Peptidase, M16
EXW43_RS19105	COG0726	polysaccharide deacetylase
EXW43_RS19110	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW43_RS19120	COG0196	riboflavin kinase activity
EXW43_RS19130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW43_RS19135	COG1550	Protein conserved in bacteria
EXW43_RS19140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW43_RS19145	COG1358	cellular component organization or biogenesis
EXW43_RS19150	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW43_RS19155	COG0195	Participates in both transcription termination and antitermination
EXW43_RS19160	COG0779	Required for maturation of 30S ribosomal subunits
EXW43_RS19170	COG0442	prolyl-tRNA aminoacylation
EXW43_RS19175	COG0750	zinc metalloprotease
EXW43_RS19185	COG4589	Belongs to the CDS family
EXW43_RS19195	COG0233	cytoplasmic translational termination
EXW43_RS19200	COG0528	UMP kinase activity
EXW43_RS19205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW43_RS19215	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW43_RS19220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW43_RS19225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW43_RS19230	COG4974	Belongs to the 'phage' integrase family
EXW43_RS19235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW43_RS19240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW43_RS19245	COG0758	DNA mediated transformation
EXW43_RS19250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW43_RS19255	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW43_RS19260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW43_RS19275	COG0335	large ribosomal subunit rRNA binding
EXW43_RS19280	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW43_RS19285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW43_RS19290	COG1837	Belongs to the UPF0109 family
EXW43_RS19300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW43_RS19310	COG0552	protein localization to endoplasmic reticulum
EXW43_RS19315	COG1196	nuclear chromosome segregation
EXW43_RS19320	COG0571	ribonuclease III activity
EXW43_RS19325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW43_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS19335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW43_RS19340	COG0416	fatty acid biosynthetic process
EXW43_RS19345	COG2050	protein possibly involved in aromatic compounds catabolism
EXW43_RS19345	COG1349	DNA-binding transcription factor activity
EXW43_RS19350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW43_RS19355	COG1461	Dihydroxyacetone kinase
EXW43_RS19360	COG1302	Protein conserved in bacteria
EXW43_RS19375	COG1564	THIamine pyrophosphokinase
EXW43_RS19380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW43_RS19390	COG0515	serine threonine protein kinase
EXW43_RS19390	COG2815	serine threonine protein kinase
EXW43_RS19395	COG0631	protein serine/threonine phosphatase activity
EXW43_RS19400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW43_RS19405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW43_RS19405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW43_RS19410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW43_RS19415	COG0242	peptide deformylase activity
EXW43_RS19420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW43_RS19425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW43_RS19430	COG1758	RNA polymerase activity
EXW43_RS19445	COG1561	YicC-like family, N-terminal region
EXW43_RS19450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW43_RS19460	COG0006	proline dipeptidase activity
EXW43_RS19480	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW43_RS19505	COG0167	dihydroorotate dehydrogenase activity
EXW43_RS19510	COG0543	2 iron, 2 sulfur cluster binding
EXW43_RS19515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW43_RS19525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW43_RS19530	COG0540	Belongs to the ATCase OTCase family
EXW43_RS19540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW43_RS19545	COG0564	pseudouridine synthase activity
EXW43_RS19550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW43_RS19560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW43_RS19565	COG3599	regulation of cell shape
EXW43_RS19570	COG2302	S4 RNA-binding domain
EXW43_RS19575	COG0762	integral membrane protein
EXW43_RS19580	COG1799	cell septum assembly
EXW43_RS19585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW43_RS19595	COG1873	PFAM PRC-barrel domain
EXW43_RS19600	COG1191	sigma factor activity
EXW43_RS19605	COG1191	sigma factor activity
EXW43_RS19615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW43_RS19620	COG0849	cell division
EXW43_RS19625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW43_RS19640	COG0772	Belongs to the SEDS family
EXW43_RS19645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW43_RS19650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW43_RS19655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW43_RS19660	COG0768	penicillin binding
EXW43_RS19665	COG0768	penicillin binding
EXW43_RS19675	COG0275	rRNA processing
EXW43_RS19680	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW43_RS19685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW43_RS19690	COG0454	-acetyltransferase
EXW43_RS19700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW43_RS19705	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW43_RS19710	COG1323	Belongs to the UPF0348 family
EXW43_RS19715	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW43_RS19720	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW43_RS19725	COG3314	Sporulation integral membrane protein YlbJ
EXW43_RS19735	COG0742	ribosomal rna small subunit methyltransferase
EXW43_RS19745	COG4471	UPF0298 protein
EXW43_RS19750	COG3679	Belongs to the UPF0342 family
EXW43_RS19755	COG0406	alpha-ribazole phosphatase activity
EXW43_RS19770	COG2340	Cysteine-rich secretory protein family
EXW43_RS19780	COG3336	cytochrome c oxidase
EXW43_RS19805	COG0109	protoheme IX farnesyltransferase activity
EXW43_RS19810	COG1612	heme a metabolic process
EXW43_RS19815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW43_RS19820	COG0772	Belongs to the SEDS family
EXW43_RS19825	COG4838	Belongs to the UPF0358 family
EXW43_RS19830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW43_RS19835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW43_RS19845	COG4896	Protein conserved in bacteria
EXW43_RS19860	COG1217	gtp-binding protein TYPA
EXW43_RS19870	COG0483	inositol monophosphate 1-phosphatase activity
EXW43_RS19880	COG4493	Belongs to the UPF0637 family
EXW43_RS19885	COG4476	Belongs to the UPF0223 family
EXW43_RS19890	COG1982	Orn Lys Arg decarboxylase major
EXW43_RS19935	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW43_RS19940	COG0022	dehydrogenase e1 component
EXW43_RS19945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW43_RS19960	COG0561	phosphatase activity
EXW43_RS19965	COG5503	Protein of unknown function (DUF1447)
EXW43_RS19970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW43_RS19975	COG0569	domain protein
EXW43_RS19985	COG1473	amidohydrolase
EXW43_RS19990	COG2171	N-acyltransferase activity
EXW43_RS19995	COG0583	DNA-binding transcription factor activity
EXW43_RS20000	COG0517	IMP dehydrogenase activity
EXW43_RS20010	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW43_RS20020	COG4703	Protein of unknown function (DUF1797)
EXW43_RS20035	COG2200	EAL domain
EXW43_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS20045	COG1408	metallophosphoesterase
EXW43_RS20090	COG2814	Major facilitator Superfamily
EXW43_RS20100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW43_RS20110	COG3209	COG3209 Rhs family protein
EXW43_RS20120	COG2205	protein histidine kinase activity
EXW43_RS20130	COG0436	Aminotransferase
EXW43_RS20135	COG1609	Transcriptional regulator
EXW43_RS20140	COG3833	ABC-type maltose transport systems, permease component
EXW43_RS20145	COG1175	transmembrane transport
EXW43_RS20150	COG2182	Extracellular solute-binding protein
EXW43_RS20160	COG0366	Alpha amylase catalytic
EXW43_RS20165	COG3842	ATPase activity
EXW43_RS20205	COG0183	Belongs to the thiolase family
EXW43_RS20240	COG1695	Transcriptional regulator
EXW43_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS20255	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW43_RS20260	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW43_RS20265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW43_RS20270	COG0436	Aminotransferase
EXW43_RS20275	COG1850	ribulose-bisphosphate carboxylase activity
EXW43_RS20280	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW43_RS20285	COG0235	Class ii aldolase
EXW43_RS20290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW43_RS20305	COG2084	Dehydrogenase
EXW43_RS20315	COG2199	diguanylate cyclase activity
EXW43_RS20320	COG0778	Nitroreductase
EXW43_RS20345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW43_RS20345	COG2190	(PTS) system
EXW43_RS20345	COG1263	PTS System
EXW43_RS20350	COG3711	transcriptional antiterminator
EXW43_RS20360	COG2188	Transcriptional regulator
EXW43_RS20365	COG0363	glucosamine-6-phosphate deaminase activity
EXW43_RS20370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW43_RS20380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW43_RS20385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW43_RS20395	COG1547	Domain of unknown function (DUF309)
EXW43_RS20405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW43_RS20410	COG4086	secreted protein
EXW43_RS20415	COG0561	phosphatase activity
EXW43_RS20420	COG0697	spore germination
EXW43_RS20435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS20460	COG0733	neurotransmitter:sodium symporter activity
EXW43_RS20480	COG1686	Belongs to the peptidase S11 family
EXW43_RS20485	COG1725	Transcriptional regulator
EXW43_RS20490	COG1131	(ABC) transporter
EXW43_RS20515	COG1846	Transcriptional regulator
EXW43_RS20530	COG0598	Magnesium transport protein CorA
EXW43_RS20545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW43_RS20555	COG4974	Belongs to the 'phage' integrase family
EXW43_RS20565	COG0735	belongs to the Fur family
EXW43_RS20570	COG1300	Membrane
EXW43_RS20590	COG0667	Aldo Keto reductase
EXW43_RS20595	COG0656	L-ascorbic acid biosynthetic process
EXW43_RS20600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW43_RS20600	COG0456	acetyltransferase
EXW43_RS20610	COG0737	Belongs to the 5'-nucleotidase family
EXW43_RS20610	COG1525	nuclease
EXW43_RS20610	COG4085	toxin activity
EXW43_RS20615	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW43_RS20625	COG0596	Alpha beta hydrolase
EXW43_RS20630	COG2056	Na+-H+ antiporter family
EXW43_RS20635	COG1609	Transcriptional regulator
EXW43_RS20640	COG0456	acetyltransferase
EXW43_RS20645	COG1073	alpha beta
EXW43_RS20660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW43_RS20660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW43_RS20665	COG0307	riboflavin synthase, alpha
EXW43_RS20670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW43_RS20670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW43_RS20685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW43_RS20690	COG4106	trans-aconitate 2-methyltransferase activity
EXW43_RS20695	COG1073	alpha beta
EXW43_RS20695	COG2226	methyltransferase
EXW43_RS20700	COG0156	8-amino-7-oxononanoate synthase activity
EXW43_RS20710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW43_RS20720	COG1757	Na H antiporter
EXW43_RS20725	COG0737	Belongs to the 5'-nucleotidase family
EXW43_RS20735	COG1522	sequence-specific DNA binding
EXW43_RS20770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW43_RS20780	COG0300	oxidoreductase activity
EXW43_RS20785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS20790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW43_RS20795	COG1760	l-serine dehydratase
EXW43_RS20800	COG1760	l-serine dehydratase
EXW43_RS20810	COG1234	tRNA 3'-trailer cleavage
EXW43_RS20825	COG1285	pathogenesis
EXW43_RS20840	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW43_RS20845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS20860	COG1376	ErfK ybiS ycfS ynhG family protein
EXW43_RS20865	COG4129	membrane
EXW43_RS20870	COG1126	abc transporter atp-binding protein
EXW43_RS20875	COG0765	amino acid transport
EXW43_RS20880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW43_RS20895	COG2816	NAD+ diphosphatase activity
EXW43_RS20900	COG2323	membrane
EXW43_RS20905	COG0772	Belongs to the SEDS family
EXW43_RS20910	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW43_RS20915	COG0022	dehydrogenase e1 component
EXW43_RS20920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW43_RS20925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW43_RS20930	COG3426	butyrate kinase activity
EXW43_RS20940	COG0280	phosphate acetyltransferase
EXW43_RS20945	COG3829	transcription factor binding
EXW43_RS20945	COG3290	protein histidine kinase activity
EXW43_RS20955	COG0584	glycerophosphoryl diester phosphodiesterase
EXW43_RS20960	COG3093	addiction module antidote protein HigA
EXW43_RS20970	COG0745	RESPONSE REGULATOR receiver
EXW43_RS20975	COG0750	zinc metalloprotease
EXW43_RS20980	COG0497	DNA recombination
EXW43_RS20985	COG1438	arginine binding
EXW43_RS20990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW43_RS20995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW43_RS21000	COG0142	geranyltranstransferase activity
EXW43_RS21005	COG1722	exodeoxyribonuclease VII activity
EXW43_RS21010	COG1570	exodeoxyribonuclease VII activity
EXW43_RS21015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW43_RS21020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW43_RS21025	COG1302	Protein conserved in bacteria
EXW43_RS21030	COG0439	Biotin carboxylase
EXW43_RS21035	COG0511	ligase activity, forming carbon-carbon bonds
EXW43_RS21080	COG3854	ATPases associated with a variety of cellular activities
EXW43_RS21100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW43_RS21105	COG0006	proline dipeptidase activity
EXW43_RS21110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW43_RS21120	COG3872	metal-dependent enzyme
EXW43_RS21130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW43_RS21165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS21175	COG1609	Transcriptional regulator
EXW43_RS21185	COG2076	Multidrug Resistance protein
EXW43_RS21190	COG2076	Multidrug Resistance protein
EXW43_RS21235	COG1725	Transcriptional regulator
EXW43_RS21250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW43_RS21255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW43_RS21260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW43_RS21265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW43_RS21290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW43_RS21315	COG4970	Tfp pilus assembly protein FimT
EXW43_RS21325	COG1459	type II secretion system
EXW43_RS21330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW43_RS21385	COG0646	methionine synthase
EXW43_RS21385	COG1410	methionine synthase
EXW43_RS21390	COG0646	methionine synthase
EXW43_RS21390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW43_RS21395	COG0626	cystathionine gamma-synthase activity
EXW43_RS21400	COG0626	cystathionine gamma-synthase activity
EXW43_RS21415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS21425	COG1940	carbohydrate kinase activity
EXW43_RS21430	COG4483	Protein conserved in bacteria
EXW43_RS21435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW43_RS21440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW43_RS21445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW43_RS21450	COG0704	Plays a role in the regulation of phosphate uptake
EXW43_RS21460	COG0581	inorganic phosphate transmembrane transporter activity
EXW43_RS21465	COG0573	inorganic phosphate transmembrane transporter activity
EXW43_RS21470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW43_RS21475	COG0768	penicillin binding
EXW43_RS21480	COG0477	Major facilitator Superfamily
EXW43_RS21485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW43_RS21505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW43_RS21510	COG0735	belongs to the Fur family
EXW43_RS21515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW43_RS21520	COG1121	(ABC) transporter
EXW43_RS21525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS21535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW43_RS21550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW43_RS21555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW43_RS21560	COG2384	SAM-dependent methyltransferase
EXW43_RS21565	COG2010	Cytochrome c
EXW43_RS21570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW43_RS21575	COG0358	DNA primase activity
EXW43_RS21585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW43_RS21590	COG0517	IMP dehydrogenase activity
EXW43_RS21595	COG1381	Involved in DNA repair and RecF pathway recombination
EXW43_RS21605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW43_RS21610	COG0295	cytidine deaminase activity
EXW43_RS21615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW43_RS21620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW43_RS21625	COG1480	7TM receptor with intracellular HD hydrolase
EXW43_RS21630	COG1702	phosphate starvation-inducible protein PhoH
EXW43_RS21645	COG1610	YqeY-like protein
EXW43_RS21650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW43_RS21655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW43_RS21660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW43_RS21670	COG0484	heat shock protein binding
EXW43_RS21675	COG0443	Heat shock 70 kDa protein
EXW43_RS21685	COG1420	regulation of RNA biosynthetic process
EXW43_RS21690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW43_RS21695	COG1733	regulation of RNA biosynthetic process
EXW43_RS21700	COG0481	GTPase activity
EXW43_RS21710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW43_RS21715	COG0268	Binds directly to 16S ribosomal RNA
EXW43_RS21720	COG1466	dna polymerase III delta subunit
EXW43_RS21730	COG2333	competence protein COMEC
EXW43_RS21730	COG0658	competence protein
EXW43_RS21735	COG2131	deaminase
EXW43_RS21740	COG1596	polysaccharide export
EXW43_RS21740	COG1555	photosystem II stabilization
EXW43_RS21745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW43_RS21750	COG2226	methyltransferase
EXW43_RS21755	COG0799	negative regulation of ribosome biogenesis
EXW43_RS21760	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW43_RS21765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW43_RS21770	COG1534	Rna-binding protein
EXW43_RS21775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW43_RS21780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW43_RS21785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW43_RS21795	COG0688	phosphatidylethanolamine metabolic process
EXW43_RS21805	COG1595	DNA-templated transcription, initiation
EXW43_RS21810	COG2357	RelA SpoT domain protein
EXW43_RS21820	COG1785	Belongs to the alkaline phosphatase family
EXW43_RS21830	COG2267	carboxylic ester hydrolase activity
EXW43_RS21870	COG3186	Phenylalanine-4-hydroxylase
EXW43_RS21875	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW43_RS21880	COG2514	catechol 2,3-dioxygenase activity
EXW43_RS21885	COG2259	Doxx family
EXW43_RS21925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS21935	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS21935	COG1454	alcohol dehydrogenase
EXW43_RS21940	COG0626	cystathionine gamma-synthase activity
EXW43_RS21945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW43_RS21950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW43_RS21955	COG2226	methyltransferase
EXW43_RS21970	COG0768	penicillin binding
EXW43_RS21975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW43_RS21980	COG0572	uridine kinase
EXW43_RS21985	COG0826	peptidase U32
EXW43_RS21990	COG0826	peptidase U32
EXW43_RS21995	COG4122	O-methyltransferase activity
EXW43_RS22000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW43_RS22010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW43_RS22015	COG4472	Bacterial protein of unknown function (DUF965)
EXW43_RS22020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW43_RS22030	COG0628	permease
EXW43_RS22050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW43_RS22060	COG0482	sulfurtransferase activity
EXW43_RS22065	COG1104	cysteine desulfurase activity
EXW43_RS22070	COG1959	2 iron, 2 sulfur cluster binding
EXW43_RS22075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW43_RS22085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW43_RS22090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW43_RS22105	COG1490	D-aminoacyl-tRNA deacylase activity
EXW43_RS22110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW43_RS22115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW43_RS22120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW43_RS22120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW43_RS22125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW43_RS22130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW43_RS22130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW43_RS22140	COG2244	polysaccharide biosynthetic process
EXW43_RS22145	COG2323	membrane
EXW43_RS22155	COG1862	Preprotein translocase
EXW43_RS22160	COG0343	queuine tRNA-ribosyltransferase activity
EXW43_RS22165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW43_RS22175	COG2255	four-way junction helicase activity
EXW43_RS22180	COG0632	four-way junction helicase activity
EXW43_RS22185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW43_RS22210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW43_RS22215	COG0157	Belongs to the NadC ModD family
EXW43_RS22220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW43_RS22225	COG1104	cysteine desulfurase activity
EXW43_RS22230	COG1827	regulation of RNA biosynthetic process
EXW43_RS22235	COG2258	MOSC domain
EXW43_RS22240	COG0077	Prephenate dehydratase
EXW43_RS22245	COG0577	efflux transmembrane transporter activity
EXW43_RS22250	COG0577	efflux transmembrane transporter activity
EXW43_RS22255	COG1136	(ABC) transporter
EXW43_RS22260	COG5002	protein histidine kinase activity
EXW43_RS22265	COG0745	RESPONSE REGULATOR receiver
EXW43_RS22270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW43_RS22275	COG3290	protein histidine kinase activity
EXW43_RS22285	COG2868	ribosomal protein
EXW43_RS22295	COG1530	ribonuclease E activity
EXW43_RS22300	COG1994	Peptidase M50
EXW43_RS22305	COG0739	heme binding
EXW43_RS22310	COG2894	cell division
EXW43_RS22315	COG0850	regulation of cytokinetic process
EXW43_RS22330	COG1077	Cell shape determining protein MreB Mrl
EXW43_RS22335	COG2003	Belongs to the UPF0758 family
EXW43_RS22340	COG0424	maF-like protein
EXW43_RS22350	COG0285	dihydrofolate synthase activity
EXW43_RS22365	COG1388	LysM domain
EXW43_RS22370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW43_RS22375	COG0113	porphobilinogen synthase activity
EXW43_RS22380	COG1587	Uroporphyrinogen-III synthase
EXW43_RS22385	COG0181	hydroxymethylbilane synthase activity
EXW43_RS22390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW43_RS22395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW43_RS22400	COG1846	Transcriptional regulator
EXW43_RS22405	COG1764	response to oxidative stress
EXW43_RS22410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW43_RS22420	COG0470	DNA polymerase III
EXW43_RS22420	COG1067	ATP-dependent peptidase activity
EXW43_RS22430	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW43_RS22460	COG0622	Phosphoesterase
EXW43_RS22470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW43_RS22475	COG5401	PFAM Sporulation and spore germination
EXW43_RS22485	COG0477	Major facilitator Superfamily
EXW43_RS22490	COG2197	response regulator
EXW43_RS22495	COG2233	PERMEase
EXW43_RS22500	COG0402	S-adenosylhomocysteine deaminase activity
EXW43_RS22505	COG1983	PspC domain protein
EXW43_RS22510	COG1396	sequence-specific DNA binding
EXW43_RS22515	COG0697	spore germination
EXW43_RS22525	COG1959	2 iron, 2 sulfur cluster binding
EXW43_RS22530	COG1668	transmembrane transport
EXW43_RS22535	COG4152	abc transporter atp-binding protein
EXW43_RS22540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW43_RS22545	COG1360	Flagellar Motor Protein
EXW43_RS22550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW43_RS22555	COG1876	peptidase activity
EXW43_RS22560	COG0824	Thioesterase
EXW43_RS22565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW43_RS22570	COG1053	succinate dehydrogenase
EXW43_RS22575	COG2009	succinate dehydrogenase
EXW43_RS22580	COG1719	4-vinyl reductase, 4VR
EXW43_RS22585	COG0322	excinuclease ABC activity
EXW43_RS22590	COG3118	belongs to the thioredoxin family
EXW43_RS22595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW43_RS22600	COG2086	electron transfer activity
EXW43_RS22605	COG1024	Enoyl-CoA hydratase
EXW43_RS22610	COG1309	transcriptional regulator
EXW43_RS22615	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS22635	COG2318	DinB family
EXW43_RS22660	COG1131	(ABC) transporter
EXW43_RS22665	COG2205	protein histidine kinase activity
EXW43_RS22670	COG0745	RESPONSE REGULATOR receiver
EXW43_RS22680	COG4895	conserved protein (DUF2196)
EXW43_RS22685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW43_RS22695	COG4509	Sortase family
EXW43_RS22700	COG1120	ATPase activity
EXW43_RS22715	COG5386	Cell surface protein
EXW43_RS22725	COG5386	Cell surface protein
EXW43_RS22730	COG1114	Component of the transport system for branched-chain amino acids
EXW43_RS22740	COG1193	negative regulation of DNA recombination
EXW43_RS22745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW43_RS22745	COG1796	DNA polymerase
EXW43_RS22750	COG1286	toxin biosynthetic process
EXW43_RS22755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW43_RS22760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW43_RS22785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW43_RS22790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW43_RS22800	COG1418	mRNA catabolic process
EXW43_RS22830	COG2814	Major facilitator Superfamily
EXW43_RS22835	COG1566	PFAM secretion protein HlyD family protein
EXW43_RS22840	COG1309	transcriptional regulator
EXW43_RS22845	COG1363	Peptidase, m42
EXW43_RS22855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW43_RS22870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW43_RS22880	COG1484	DNA-dependent DNA replication
EXW43_RS22885	COG3611	Membrane attachment protein
EXW43_RS22890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW43_RS22895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW43_RS22900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW43_RS22905	COG0237	dephospho-CoA kinase activity
EXW43_RS22910	COG1971	Probably functions as a manganese efflux pump
EXW43_RS22920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW43_RS22920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW43_RS22925	COG5002	protein histidine kinase activity
EXW43_RS22930	COG0745	RESPONSE REGULATOR receiver
EXW43_RS22945	COG0039	L-malate dehydrogenase activity
EXW43_RS22950	COG0538	isocitrate dehydrogenase activity
EXW43_RS22955	COG0372	Belongs to the citrate synthase family
EXW43_RS22965	COG0628	permease
EXW43_RS22970	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW43_RS22980	COG0205	6-phosphofructokinase activity
EXW43_RS22990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW43_RS22995	COG1725	Transcriptional regulator
EXW43_RS23000	COG0281	malic enzyme
EXW43_RS23005	COG0587	DNA-directed DNA polymerase activity
EXW43_RS23020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW43_RS23035	COG4109	DRTGG domain
EXW43_RS23050	COG0006	proline dipeptidase activity
EXW43_RS23080	COG0662	Cupin 2, conserved barrel domain protein
EXW43_RS23090	COG1476	TRANSCRIPTIONal
EXW43_RS23105	COG1028	Short-chain dehydrogenase reductase Sdr
EXW43_RS23110	COG0589	response to stress
EXW43_RS23130	COG0165	Argininosuccinate lyase
EXW43_RS23150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS23170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW43_RS23175	COG0827	DNA restriction-modification system
EXW43_RS23180	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW43_RS23185	COG3874	Sporulation protein YtfJ
EXW43_RS23200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW43_RS23210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW43_RS23225	COG1104	cysteine desulfurase activity
EXW43_RS23230	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW43_RS23245	COG1309	transcriptional regulator
EXW43_RS23250	COG1956	GAF domain-containing protein
EXW43_RS23255	COG0626	cystathionine gamma-synthase activity
EXW43_RS23260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW43_RS23285	COG1595	DNA-templated transcription, initiation
EXW43_RS23295	COG0110	maltose O-acetyltransferase activity
EXW43_RS23300	COG0456	acetyltransferase
EXW43_RS23305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW43_RS23310	COG0454	-acetyltransferase
EXW43_RS23315	COG0517	IMP dehydrogenase activity
EXW43_RS23320	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW43_RS23325	COG2267	carboxylic ester hydrolase activity
EXW43_RS23335	COG0745	RESPONSE REGULATOR receiver
EXW43_RS23340	COG5002	protein histidine kinase activity
EXW43_RS23345	COG0666	response to abiotic stimulus
EXW43_RS23355	COG1970	mechanosensitive ion channel activity
EXW43_RS23375	COG1609	Transcriptional regulator
EXW43_RS23390	COG4851	CamS sex pheromone cAM373 precursor
EXW43_RS23395	COG3118	belongs to the thioredoxin family
EXW43_RS23405	COG2309	aminopeptidase activity
EXW43_RS23435	COG0697	spore germination
EXW43_RS23440	COG0789	Transcriptional regulator
EXW43_RS23445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW43_RS23455	COG1674	ftsk spoiiie
EXW43_RS23470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW43_RS23475	COG4848	Belongs to the UPF0354 family
EXW43_RS23480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS23485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW43_RS23490	COG1363	Peptidase, m42
EXW43_RS23500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS23505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW43_RS23515	COG0510	thiamine kinase activity
EXW43_RS23520	COG1523	belongs to the glycosyl hydrolase 13 family
EXW43_RS23530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW43_RS23535	COG1349	DNA-binding transcription factor activity
EXW43_RS23540	COG1187	pseudouridine synthase activity
EXW43_RS23545	COG2244	polysaccharide biosynthetic process
EXW43_RS23550	COG2081	HI0933 family
EXW43_RS23555	COG2814	Major facilitator Superfamily
EXW43_RS23565	COG3832	glyoxalase III activity
EXW43_RS23585	COG1329	Transcriptional regulator
EXW43_RS23610	COG0314	molybdopterin synthase activity
EXW43_RS23615	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW43_RS23620	COG0303	'Molybdopterin
EXW43_RS23625	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW43_RS23630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW43_RS23635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW43_RS23655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW43_RS23665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW43_RS23705	COG0495	leucyl-tRNA aminoacylation
EXW43_RS23710	COG2814	Major facilitator Superfamily
EXW43_RS23715	COG0475	glutathione-regulated potassium exporter activity
EXW43_RS23720	COG0490	domain, Protein
EXW43_RS23725	COG0582	viral genome integration into host DNA
EXW43_RS23735	COG1136	(ABC) transporter
EXW43_RS23750	COG1242	4 iron, 4 sulfur cluster binding
EXW43_RS23755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW43_RS23760	COG1131	(ABC) transporter
EXW43_RS23770	COG1794	racemase activity, acting on amino acids and derivatives
EXW43_RS23785	COG2267	carboxylic ester hydrolase activity
EXW43_RS23790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW43_RS23795	COG0671	phosphoesterase, PA-phosphatase related
EXW43_RS23800	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS23815	COG0746	molybdenum cofactor guanylyltransferase activity
EXW43_RS23835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW43_RS23840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW43_RS23880	COG5002	protein histidine kinase activity
EXW43_RS23885	COG3852	Histidine kinase
EXW43_RS23890	COG0753	catalase activity
EXW43_RS23895	COG2267	carboxylic ester hydrolase activity
EXW43_RS23905	COG1368	sulfuric ester hydrolase activity
EXW43_RS23915	COG4895	conserved protein (DUF2196)
EXW43_RS23930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW43_RS23935	COG1116	anion transmembrane transporter activity
EXW43_RS23940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW43_RS23965	COG0494	nUDIX hydrolase
EXW43_RS24000	COG2076	Multidrug Resistance protein
EXW43_RS24005	COG2076	Multidrug Resistance protein
EXW43_RS24010	COG0789	Transcriptional regulator
EXW43_RS24015	COG1854	S-ribosylhomocysteine lyase activity
EXW43_RS24025	COG0288	reversible hydration of carbon dioxide
EXW43_RS24030	COG1271	oxidase subunit
EXW43_RS24035	COG1294	oxidase, subunit
EXW43_RS24055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS24080	COG1842	Phage shock protein A
EXW43_RS24105	COG3859	Proton-coupled thiamine transporter YuaJ
EXW43_RS24110	COG5002	protein histidine kinase activity
EXW43_RS24115	COG0745	RESPONSE REGULATOR receiver
EXW43_RS24140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW43_RS24145	COG1597	lipid kinase activity
EXW43_RS24175	COG1136	(ABC) transporter
EXW43_RS24205	COG5002	protein histidine kinase activity
EXW43_RS24215	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS24230	COG0577	efflux transmembrane transporter activity
EXW43_RS24235	COG1136	(ABC) transporter
EXW43_RS24240	COG3708	Transcriptional regulator
EXW43_RS24240	COG2207	Transcriptional regulator
EXW43_RS24250	COG1131	(ABC) transporter
EXW43_RS24260	COG5658	integral membrane protein
EXW43_RS24265	COG0640	Transcriptional regulator
EXW43_RS24270	COG0745	RESPONSE REGULATOR receiver
EXW43_RS24275	COG2205	protein histidine kinase activity
EXW43_RS24280	COG0577	efflux transmembrane transporter activity
EXW43_RS24285	COG0577	efflux transmembrane transporter activity
EXW43_RS24290	COG1136	(ABC) transporter
EXW43_RS24295	COG0577	efflux transmembrane transporter activity
EXW43_RS24310	COG2188	Transcriptional regulator
EXW43_RS24330	COG3964	amidohydrolase
EXW43_RS24350	COG4948	Mandelate Racemase Muconate Lactonizing
EXW43_RS24355	COG0318	PFAM AMP-dependent synthetase and ligase
EXW43_RS24365	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW43_RS24375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW43_RS24380	COG1169	isochorismate synthase
EXW43_RS24385	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW43_RS24390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW43_RS24395	COG1278	Cold shock
EXW43_RS24405	COG0789	Transcriptional regulator
EXW43_RS24415	COG0058	SHG alpha-glucan phosphorylase activity
EXW43_RS24425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW43_RS24430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW43_RS24435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW43_RS24585	COG1285	pathogenesis
EXW43_RS24590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW43_RS24600	COG0166	Belongs to the GPI family
EXW43_RS24605	COG2155	Conserved Protein
EXW43_RS24610	COG1098	S1 RNA binding domain
EXW43_RS24615	COG0436	Aminotransferase
EXW43_RS24620	COG1522	sequence-specific DNA binding
EXW43_RS24625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW43_RS24630	COG2267	carboxylic ester hydrolase activity
EXW43_RS24640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW43_RS24660	COG5018	Exonuclease
EXW43_RS24665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW43_RS24690	COG2050	protein possibly involved in aromatic compounds catabolism
EXW43_RS24700	COG1268	BioY protein
EXW43_RS24705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW43_RS24710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW43_RS24720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW43_RS24725	COG3584	3D domain protein
EXW43_RS24740	COG1252	NADH dehydrogenase
EXW43_RS24745	COG0492	ferredoxin-NADP+ reductase activity
EXW43_RS24750	COG3708	Transcriptional regulator
EXW43_RS24765	COG1683	Conserved Protein
EXW43_RS24785	COG0316	Belongs to the HesB IscA family
EXW43_RS24790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW43_RS24795	COG4844	belongs to the
EXW43_RS24800	COG1252	NADH dehydrogenase
EXW43_RS24810	COG0390	transport system, permease component
EXW43_RS24815	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW43_RS24845	COG4837	Protein of unknown function (DUF1462)
EXW43_RS24850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW43_RS24860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW43_RS24865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW43_RS24880	COG0577	efflux transmembrane transporter activity
EXW43_RS24880	COG1136	(ABC) transporter
EXW43_RS24885	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW43_RS24900	COG0647	UMP catabolic process
EXW43_RS24910	COG2445	Protein of unknown function DUF86
EXW43_RS24915	COG1494	fructose-1,6-bisphosphatase
EXW43_RS24930	COG4470	Protein conserved in bacteria
EXW43_RS24940	COG0789	Transcriptional regulator
EXW43_RS24945	COG4377	Putative membrane peptidase family (DUF2324)
EXW43_RS24965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW43_RS24970	COG0739	heme binding
EXW43_RS24980	COG3377	Domain of unknown function (DUF1805)
EXW43_RS24985	COG0737	Belongs to the 5'-nucleotidase family
EXW43_RS24990	COG1695	Transcriptional regulator
EXW43_RS25000	COG0719	Fe-S assembly protein
EXW43_RS25005	COG0822	iron-sulfur transferase activity
EXW43_RS25010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW43_RS25015	COG0719	Fe-S assembly protein
EXW43_RS25020	COG0396	ATPase activity
EXW43_RS25025	COG1464	Belongs to the NlpA lipoprotein family
EXW43_RS25030	COG1464	Belongs to the NlpA lipoprotein family
EXW43_RS25035	COG2011	ABC-type metal ion transport system permease component
EXW43_RS25040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW43_RS25050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW43_RS25055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW43_RS25060	COG0509	glycine decarboxylation via glycine cleavage system
EXW43_RS25065	COG1393	Belongs to the ArsC family
EXW43_RS25105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS25120	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS25125	COG0183	Belongs to the thiolase family
EXW43_RS25130	COG1024	Enoyl-CoA hydratase
EXW43_RS25130	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW43_RS25140	COG1686	Belongs to the peptidase S11 family
EXW43_RS25145	COG0506	proline dehydrogenase activity
EXW43_RS25155	COG0011	TIGRFAM Protein of
EXW43_RS25160	COG0840	transmembrane signaling receptor activity
EXW43_RS25175	COG2814	Major facilitator Superfamily
EXW43_RS25180	COG0531	amino acid
EXW43_RS25205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW43_RS25235	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS25245	COG1376	ErfK ybiS ycfS ynhG family protein
EXW43_RS25250	COG0745	RESPONSE REGULATOR receiver
EXW43_RS25255	COG5002	protein histidine kinase activity
EXW43_RS25265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW43_RS25275	COG0840	transmembrane signaling receptor activity
EXW43_RS25280	COG0840	transmembrane signaling receptor activity
EXW43_RS25285	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW43_RS25290	COG3227	Zinc metalloprotease (Elastase)
EXW43_RS25295	COG1741	Belongs to the pirin family
EXW43_RS25310	COG0586	Pfam SNARE associated Golgi protein
EXW43_RS25315	COG0475	glutathione-regulated potassium exporter activity
EXW43_RS25320	COG0490	domain, Protein
EXW43_RS25325	COG1115	amino acid carrier protein
EXW43_RS25330	COG0783	Belongs to the Dps family
EXW43_RS25340	COG2318	DinB family
EXW43_RS25345	COG1611	Belongs to the LOG family
EXW43_RS25355	COG1528	Iron-storage protein
EXW43_RS25360	COG2311	Membrane
EXW43_RS25365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS25370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS25375	COG1115	amino acid carrier protein
EXW43_RS25380	COG1115	amino acid carrier protein
EXW43_RS25385	COG2910	NAD(P)H-binding
EXW43_RS25395	COG0656	L-ascorbic acid biosynthetic process
EXW43_RS25400	COG2814	Major facilitator Superfamily
EXW43_RS25405	COG1733	regulation of RNA biosynthetic process
EXW43_RS25415	COG1252	NADH dehydrogenase
EXW43_RS25435	COG0840	transmembrane signaling receptor activity
EXW43_RS25435	COG3290	protein histidine kinase activity
EXW43_RS25445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW43_RS25465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW43_RS25480	COG4224	UPF0291 protein
EXW43_RS25485	COG1335	isochorismatase
EXW43_RS25490	COG1522	sequence-specific DNA binding
EXW43_RS25500	COG1522	sequence-specific DNA binding
EXW43_RS25505	COG0288	reversible hydration of carbon dioxide
EXW43_RS25510	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW43_RS25515	COG2233	PERMEase
EXW43_RS25540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS25560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW43_RS25565	COG0557	exoribonuclease II activity
EXW43_RS25570	COG1647	Serine aminopeptidase, S33
EXW43_RS25575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW43_RS25580	COG1346	cytolysis
EXW43_RS25595	COG0148	phosphopyruvate hydratase activity
EXW43_RS25605	COG0149	triose-phosphate isomerase activity
EXW43_RS25610	COG0126	phosphoglycerate kinase activity
EXW43_RS25615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW43_RS25630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW43_RS25665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS25680	COG2323	membrane
EXW43_RS25690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW43_RS25695	COG1481	regulation of sporulation
EXW43_RS25700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW43_RS25705	COG1660	Displays ATPase and GTPase activities
EXW43_RS25710	COG1051	belongs to the nudix hydrolase family
EXW43_RS25720	COG0492	ferredoxin-NADP+ reductase activity
EXW43_RS25725	COG0457	Tetratricopeptide repeat
EXW43_RS25730	COG0110	maltose O-acetyltransferase activity
EXW43_RS25735	COG0546	phosphoglycolate phosphatase activity
EXW43_RS25740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW43_RS25745	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW43_RS25750	COG1950	PFAM Membrane protein of
EXW43_RS25755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW43_RS25775	COG0789	Transcriptional regulator
EXW43_RS25810	COG0583	DNA-binding transcription factor activity
EXW43_RS25815	COG0789	Transcriptional regulator
EXW43_RS25820	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW43_RS25825	COG0488	(ABC) transporter
EXW43_RS25835	COG1132	(ABC) transporter
EXW43_RS25840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW43_RS25845	COG0793	Belongs to the peptidase S41A family
EXW43_RS25845	COG3409	Peptidoglycan-binding domain 1 protein
EXW43_RS25850	COG2177	Part of the ABC transporter FtsEX involved in
EXW43_RS25855	COG2884	Cell division ATP-binding protein ftsE
EXW43_RS25880	COG1131	(ABC) transporter
EXW43_RS25915	COG1278	Cold shock
EXW43_RS25920	COG1040	competence protein
EXW43_RS25925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW43_RS25930	COG1388	LysM domain
EXW43_RS25930	COG0791	NLP P60 protein
EXW43_RS25935	COG1733	regulation of RNA biosynthetic process
EXW43_RS25940	COG1307	EDD domain protein, DegV family
EXW43_RS25945	COG1739	Uncharacterized protein family UPF0029
EXW43_RS25950	COG1316	TRANSCRIPTIONal
EXW43_RS25955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW43_RS25960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW43_RS25965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW43_RS25975	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW43_RS25975	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW43_RS25995	COG1486	melibiose metabolic process
EXW43_RS26000	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW43_RS26005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW43_RS26025	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW43_RS26035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW43_RS26040	COG1301	dicarboxylic acid transport
EXW43_RS26055	COG1511	domain protein
EXW43_RS26060	COG0583	DNA-binding transcription factor activity
EXW43_RS26065	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW43_RS26075	COG1271	oxidase subunit
EXW43_RS26080	COG1294	oxidase, subunit
EXW43_RS26085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW43_RS26090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW43_RS26095	COG1620	l-lactate permease
EXW43_RS26105	COG2389	metal-binding protein
EXW43_RS26115	COG1368	sulfuric ester hydrolase activity
EXW43_RS26125	COG0791	NLP P60 protein
EXW43_RS26125	COG1388	LysM domain
EXW43_RS26130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW43_RS26140	COG1215	transferase activity, transferring glycosyl groups
EXW43_RS26145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW43_RS26150	COG3584	3D domain protein
EXW43_RS26150	COG1388	LysM domain
EXW43_RS26165	COG4715	Zinc finger, swim domain protein
EXW43_RS26170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW43_RS26230	COG0577	efflux transmembrane transporter activity
EXW43_RS26235	COG1136	(ABC) transporter
EXW43_RS26260	COG3850	Histidine kinase
EXW43_RS26260	COG5002	protein histidine kinase activity
EXW43_RS26265	COG0745	RESPONSE REGULATOR receiver
EXW43_RS26270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW43_RS26275	COG1316	TRANSCRIPTIONal
EXW43_RS26285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW43_RS26295	COG1215	transferase activity, transferring glycosyl groups
EXW43_RS26325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW43_RS26330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW43_RS26335	COG1086	Polysaccharide biosynthesis protein
EXW43_RS26340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW43_RS26345	COG4464	protein tyrosine phosphatase activity
EXW43_RS26350	COG0489	protein tyrosine kinase activity
EXW43_RS26355	COG3944	biosynthesis protein
EXW43_RS26365	COG1132	(ABC) transporter
EXW43_RS26395	COG0367	asparagine synthase
EXW43_RS26400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW43_RS26410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW43_RS26420	COG1216	Glycosyl transferase, family 2
EXW43_RS26455	COG1215	transferase activity, transferring glycosyl groups
EXW43_RS26475	COG0463	Glycosyl transferase, family 2
EXW43_RS26475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW43_RS26485	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS26490	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS26495	COG1086	Polysaccharide biosynthesis protein
EXW43_RS26500	COG0489	protein tyrosine kinase activity
EXW43_RS26505	COG3944	biosynthesis protein
EXW43_RS26510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW43_RS26515	COG0438	transferase activity, transferring glycosyl groups
EXW43_RS26520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW43_RS26520	COG1215	transferase activity, transferring glycosyl groups
EXW43_RS26530	COG1134	teichoic acid transport
EXW43_RS26535	COG1682	transport, permease protein
EXW43_RS26540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW43_RS26545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW43_RS26550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW43_RS26560	COG1609	Transcriptional regulator
EXW43_RS26570	COG0739	heme binding
EXW43_RS26585	COG3279	Response regulator of the LytR AlgR family
EXW43_RS26590	COG2385	sporulation resulting in formation of a cellular spore
EXW43_RS26605	COG4836	Membrane
EXW43_RS26610	COG1007	ATP synthesis coupled electron transport
EXW43_RS26615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW43_RS26620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW43_RS26625	COG0713	ATP synthesis coupled electron transport
EXW43_RS26630	COG0839	Belongs to the complex I subunit 6 family
EXW43_RS26640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW43_RS26645	COG0649	NAD binding
EXW43_RS26650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW43_RS26655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW43_RS26660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW43_RS26665	COG5001	Diguanylate cyclase
EXW43_RS26665	COG3300	MHYT domain
EXW43_RS26680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW43_RS26685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW43_RS26690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW43_RS26695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW43_RS26700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW43_RS26705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW43_RS26715	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW43_RS26750	COG0698	ribose 5-phosphate isomerase
EXW43_RS26760	COG2190	(PTS) system
EXW43_RS26765	COG2259	Doxx family
EXW43_RS26770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW43_RS26780	COG1971	Probably functions as a manganese efflux pump
EXW43_RS26785	COG0009	L-threonylcarbamoyladenylate synthase
EXW43_RS26800	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW43_RS26805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW43_RS26810	COG1435	thymidine kinase activity
EXW43_RS26820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW43_RS26825	COG1494	fructose-1,6-bisphosphatase
EXW43_RS26845	COG4821	SIS domain
EXW43_RS26850	COG0504	CTP synthase activity
EXW43_RS26855	COG3343	RNA polymerase activity
EXW43_RS26865	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS26870	COG1960	acyl-CoA dehydrogenase activity
EXW43_RS26875	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW43_RS26880	COG0183	Belongs to the thiolase family
EXW43_RS26885	COG0247	lactate metabolic process
EXW43_RS26885	COG2181	nitrate reductase activity
EXW43_RS26890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW43_RS26895	COG4294	response to UV
EXW43_RS26900	COG3300	MHYT domain
EXW43_RS26900	COG5001	Diguanylate cyclase
EXW43_RS26920	COG2197	response regulator
EXW43_RS26925	COG4585	Histidine kinase
EXW43_RS26930	COG0842	Transport permease protein
EXW43_RS26935	COG1131	(ABC) transporter
EXW43_RS26940	COG0024	Methionine aminopeptidase
EXW43_RS26945	COG2234	aminopeptidase activity
EXW43_RS26965	COG4506	Protein conserved in bacteria
EXW43_RS26970	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW43_RS26985	COG0010	Belongs to the arginase family
EXW43_RS26990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW43_RS26995	COG2814	Major facilitator Superfamily
EXW43_RS27000	COG0789	Transcriptional regulator
EXW43_RS27005	COG0584	glycerophosphoryl diester phosphodiesterase
EXW43_RS27010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW43_RS27020	COG1994	Peptidase M50
EXW43_RS27030	COG1078	dGTPase activity
EXW43_RS27035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW43_RS27040	COG1120	ATPase activity
EXW43_RS27045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS27050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW43_RS27055	COG4844	belongs to the
EXW43_RS27070	COG0280	phosphate acetyltransferase
EXW43_RS27075	COG3253	May function as heme-dependent peroxidase
EXW43_RS27085	COG3773	Cell wall hydrolase
EXW43_RS27095	COG2363	Small membrane protein
EXW43_RS27110	COG2233	PERMEase
EXW43_RS27115	COG0561	phosphatase activity
EXW43_RS27120	COG2814	Major facilitator Superfamily
EXW43_RS27125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW43_RS27130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW43_RS27135	COG1131	(ABC) transporter
EXW43_RS27140	COG2755	lipolytic protein G-D-S-L family
EXW43_RS27145	COG1609	Transcriptional regulator
EXW43_RS27155	COG0460	homoserine dehydrogenase
EXW43_RS27160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW43_RS27165	COG2873	o-acetylhomoserine
EXW43_RS27180	COG2197	response regulator
EXW43_RS27185	COG4585	Histidine kinase
EXW43_RS27185	COG2203	Gaf domain
EXW43_RS27190	COG0351	phosphomethylpyrimidine kinase
EXW43_RS27195	COG3706	GGDEF domain
EXW43_RS27200	COG2879	small protein
EXW43_RS27205	COG1966	Carbon starvation protein
EXW43_RS27210	COG3279	Response regulator of the LytR AlgR family
EXW43_RS27215	COG0477	Major facilitator Superfamily
EXW43_RS27250	COG1607	acyl-coa hydrolase
EXW43_RS27255	COG1216	Glycosyl transferase, family 2
EXW43_RS27265	COG1216	Glycosyl transferase, family 2
EXW43_RS27275	COG4485	Bacterial membrane protein, YfhO
EXW43_RS27280	COG0463	Glycosyl transferase, family 2
EXW43_RS27295	COG1309	transcriptional regulator
EXW43_RS27300	COG0488	(ABC) transporter
EXW43_RS27305	COG1309	transcriptional regulator
EXW43_RS27310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW43_RS27315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW43_RS27315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW43_RS27320	COG0628	permease
EXW43_RS27330	COG1380	Effector of murein hydrolase LrgA
EXW43_RS27335	COG3279	Response regulator of the LytR AlgR family
EXW43_RS27340	COG3275	phosphorelay sensor kinase activity
EXW43_RS27345	COG2814	Major facilitator Superfamily
EXW43_RS27350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW43_RS27355	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW43_RS27360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW43_RS27385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW43_RS27390	COG1272	protein, Hemolysin III
EXW43_RS27415	COG1164	Oligoendopeptidase f
EXW43_RS27425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW43_RS27435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW43_RS27440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW43_RS27445	COG4853	Protein conserved in bacteria
EXW43_RS27455	COG5002	protein histidine kinase activity
EXW43_RS27460	COG0745	RESPONSE REGULATOR receiver
EXW43_RS27490	COG0305	Participates in initiation and elongation during chromosome replication
EXW43_RS27495	COG0359	binds to the 23S rRNA
EXW43_RS27500	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW43_RS27505	COG4241	membrane
EXW43_RS27515	COG0629	single-stranded DNA binding
EXW43_RS27520	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW43_RS27525	COG0012	GTP binding
EXW43_RS27530	COG4481	Protein conserved in bacteria
EXW43_RS27535	COG0668	transmembrane transport
EXW43_RS27545	COG1475	DNA binding
EXW43_RS27550	COG1192	Involved in chromosome partitioning
EXW43_RS27555	COG1475	DNA binding
EXW43_RS27560	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW43_RS27565	COG0445	tRNA wobble uridine modification
EXW43_RS27570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW43_RS27575	COG1847	R3H domain protein
EXW43_RS27580	COG0706	membrane insertase activity
EXW43_RS27585	COG0594	ribonuclease P activity
EXW43_RS27590	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW43_RS27640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW43_RS27670	COG0582	viral genome integration into host DNA
EXW43_RS27695	COG4974	Belongs to the 'phage' integrase family
EXW43_RS27765	COG4974	Belongs to the 'phage' integrase family
EXW43_RS27775	COG0768	penicillin binding
EXW43_RS27810	COG2732	(Barnase) inhibitor
EXW43_RS27880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW43_RS27890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW43_RS27955	COG0582	viral genome integration into host DNA
EXW43_RS27960	COG0772	Belongs to the SEDS family
EXW43_RS27970	COG0741	lytic transglycosylase activity
EXW43_RS27985	COG0577	efflux transmembrane transporter activity
EXW43_RS27990	COG1136	(ABC) transporter
EXW43_RS28040	COG1595	DNA-templated transcription, initiation
EXW43_RS28100	COG2002	toxin-antitoxin pair type II binding
EXW43_RS28145	COG2732	(Barnase) inhibitor
EXW43_RS28185	COG0531	amino acid
EXW43_RS28225	COG2226	methyltransferase
EXW43_RS28235	COG4555	ABC transporter
EXW43_RS28255	COG0720	synthase
EXW43_RS28265	COG0302	gtp cyclohydrolase
EXW43_RS28320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW43_RS28420	COG1012	belongs to the aldehyde dehydrogenase family
EXW43_RS28420	COG1454	alcohol dehydrogenase
EXW43_RS28445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW43_RS28455	COG2707	UPF0756 membrane protein
EXW43_RS28460	COG0596	Alpha beta hydrolase
EXW43_RS28465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW43_RS28490	COG1388	LysM domain
EXW43_RS28510	COG0494	nUDIX hydrolase
EXW43_RS28515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS28520	COG5566	PFAM Mor transcription activator
EXW43_RS28605	COG0791	NLP P60 protein
EXW43_RS28605	COG3883	PFAM NLP P60 protein
EXW43_RS28730	COG1192	Involved in chromosome partitioning
EXW43_RS28865	COG3773	Cell wall hydrolase
EXW43_RS28885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW43_RS28900	COG1674	ftsk spoiiie
EXW43_RS28915	COG2002	toxin-antitoxin pair type II binding
EXW43_RS28940	COG0741	lytic transglycosylase activity
EXW43_RS28965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW43_RS28990	COG2002	toxin-antitoxin pair type II binding
EXW43_RS29025	COG0457	Tetratricopeptide repeat
EXW43_RS29120	COG2755	lipolytic protein G-D-S-L family
EXW43_RS29120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW43_RS29175	COG0583	DNA-binding transcription factor activity
EXW43_RS29180	COG1942	4-Oxalocrotonate Tautomerase
EXW43_RS29190	COG1073	alpha beta
EXW43_RS29265	COG0577	efflux transmembrane transporter activity
EXW43_RS29270	COG1136	(ABC) transporter
EXW43_RS29275	COG0745	RESPONSE REGULATOR receiver
EXW43_RS29345	COG2814	Major facilitator Superfamily
EXW43_RS29370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW43_RS29385	COG2002	toxin-antitoxin pair type II binding
EXW43_RS29415	COG0582	viral genome integration into host DNA
EXW43_RS29565	COG4974	Belongs to the 'phage' integrase family
EXW43_RS29645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW43_RS29700	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW43_RS29715	COG2002	toxin-antitoxin pair type II binding
EXW43_RS29740	COG2333	competence protein COMEC
EXW43_RS29740	COG0658	competence protein
EXW43_RS29805	COG3409	Peptidoglycan-binding domain 1 protein
EXW43_RS29805	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS29865	COG0577	efflux transmembrane transporter activity
EXW43_RS29870	COG1136	(ABC) transporter
EXW43_RS29890	COG3227	Zinc metalloprotease (Elastase)
EXW43_RS29900	COG3409	Peptidoglycan-binding domain 1 protein
EXW43_RS29900	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS29930	COG2312	Erythromycin esterase
EXW43_RS30040	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW43_RS30070	COG0443	Heat shock 70 kDa protein
EXW43_RS30125	COG0577	efflux transmembrane transporter activity
EXW43_RS30125	COG1136	(ABC) transporter
EXW43_RS30455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW43_RS30500	COG0582	viral genome integration into host DNA
EXW43_RS30695	COG2814	Major facilitator Superfamily
EXW43_RS30985	COG2373	Large extracellular alpha-helical protein