locus-tag	class	description
EXW56_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW56_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW56_RS00015	COG2501	S4 domain
EXW56_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW56_RS00025	COG0187	DNA topoisomerase II activity
EXW56_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW56_RS00065	COG0516	GMP reductase activity
EXW56_RS00065	COG0517	IMP dehydrogenase activity
EXW56_RS00070	COG1686	Belongs to the peptidase S11 family
EXW56_RS00100	COG1428	Deoxynucleoside kinase
EXW56_RS00105	COG1428	Deoxynucleoside kinase
EXW56_RS00110	COG1335	isochorismatase
EXW56_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW56_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW56_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW56_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW56_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW56_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW56_RS00190	COG0470	DNA polymerase III
EXW56_RS00195	COG1774	PSP1 C-terminal conserved region
EXW56_RS00200	COG4467	Involved in initiation control of chromosome replication
EXW56_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW56_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW56_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW56_RS00230	COG0084	hydrolase, TatD family'
EXW56_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW56_RS00250	COG4466	Protein conserved in bacteria
EXW56_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW56_RS00270	COG0251	oxidation-reduction process
EXW56_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW56_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW56_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW56_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW56_RS00310	COG2244	polysaccharide biosynthetic process
EXW56_RS00315	COG3956	TIGRFAM MazG family protein
EXW56_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW56_RS00340	COG1098	S1 RNA binding domain
EXW56_RS00355	COG2208	phosphoserine phosphatase activity
EXW56_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW56_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW56_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW56_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW56_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW56_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW56_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW56_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW56_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW56_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW56_RS00420	COG1396	sequence-specific DNA binding
EXW56_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW56_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW56_RS00515	COG3880	PFAM UvrB UvrC protein
EXW56_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW56_RS00525	COG0542	response to heat
EXW56_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW56_RS00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW56_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW56_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW56_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW56_RS00560	COG1045	serine acetyltransferase
EXW56_RS00565	COG0215	cysteine-tRNA ligase activity
EXW56_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW56_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW56_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW56_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW56_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW56_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW56_RS00610	COG0081	regulation of translation
EXW56_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW56_RS00620	COG0222	ribosome binding
EXW56_RS00625	COG2813	Specifically methylates the guanine in position
EXW56_RS00630	COG0085	RNA polymerase activity
EXW56_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW56_RS00640	COG1358	cellular component organization or biogenesis
EXW56_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW56_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW56_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW56_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW56_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW56_RS00675	COG0088	Forms part of the polypeptide exit tunnel
EXW56_RS00680	COG0089	rRNA binding
EXW56_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW56_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW56_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW56_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW56_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW56_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW56_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW56_RS00760	COG1841	ribosomal large subunit assembly
EXW56_RS00765	COG0200	Binds to the 23S rRNA
EXW56_RS00770	COG0201	protein transport
EXW56_RS00775	COG0563	adenylate kinase activity
EXW56_RS00780	COG0024	Methionine aminopeptidase
EXW56_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW56_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW56_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW56_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW56_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS00855	COG0489	protein tyrosine kinase activity
EXW56_RS00865	COG2194	sulfuric ester hydrolase activity
EXW56_RS00870	COG0726	polysaccharide deacetylase
EXW56_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW56_RS00955	COG4856	YbbR-like protein
EXW56_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS00990	COG2011	ABC-type metal ion transport system permease component
EXW56_RS01000	COG1464	Belongs to the NlpA lipoprotein family
EXW56_RS01010	COG0277	FAD linked oxidase domain protein
EXW56_RS01015	COG2271	Major facilitator Superfamily
EXW56_RS01025	COG2814	Major facilitator Superfamily
EXW56_RS01045	COG0601	transmembrane transport
EXW56_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW56_RS01055	COG0444	Belongs to the ABC transporter superfamily
EXW56_RS01060	COG4608	Belongs to the ABC transporter superfamily
EXW56_RS01065	COG4166	transmembrane transport
EXW56_RS01075	COG2207	Transcriptional regulator
EXW56_RS01090	COG4166	transmembrane transport
EXW56_RS01095	COG4166	transmembrane transport
EXW56_RS01100	COG0656	L-ascorbic acid biosynthetic process
EXW56_RS01105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW56_RS01115	COG4149	molybdate abc transporter
EXW56_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW56_RS01125	COG1910	domain protein
EXW56_RS01135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW56_RS01165	COG0697	spore germination
EXW56_RS01180	COG0204	Acyl-transferase
EXW56_RS01190	COG1609	Transcriptional regulator
EXW56_RS01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS01220	COG5298	Protein conserved in bacteria
EXW56_RS01245	COG0488	(ABC) transporter
EXW56_RS01250	COG4585	Histidine kinase
EXW56_RS01255	COG2197	response regulator
EXW56_RS01260	COG1131	(ABC) transporter
EXW56_RS01265	COG1511	domain protein
EXW56_RS01265	COG0842	Transport permease protein
EXW56_RS01270	COG0842	Transport permease protein
EXW56_RS01280	COG0747	negative chemotaxis
EXW56_RS01290	COG0601	transmembrane transport
EXW56_RS01295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW56_RS01300	COG0444	Belongs to the ABC transporter superfamily
EXW56_RS01305	COG4608	Belongs to the ABC transporter superfamily
EXW56_RS01310	COG0561	phosphatase activity
EXW56_RS01340	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW56_RS01345	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW56_RS01355	COG0531	amino acid
EXW56_RS01360	COG2814	Major facilitator Superfamily
EXW56_RS01370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW56_RS01380	COG4294	response to UV
EXW56_RS01385	COG0705	Rhomboid family
EXW56_RS01390	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW56_RS01395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW56_RS01400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW56_RS01405	COG0864	Transcriptional regulator
EXW56_RS01410	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW56_RS01415	COG2183	response to ionizing radiation
EXW56_RS01515	COG0802	atpase or kinase
EXW56_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
EXW56_RS01525	COG0456	acetyltransferase
EXW56_RS01535	COG0488	(ABC) transporter
EXW56_RS01540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW56_RS01550	COG1266	CAAX protease self-immunity
EXW56_RS01555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW56_RS01560	COG0459	protein refolding
EXW56_RS01590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW56_RS01590	COG0519	Catalyzes the synthesis of GMP from XMP
EXW56_RS01595	COG2252	PERMEase
EXW56_RS01605	COG5002	protein histidine kinase activity
EXW56_RS01625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW56_RS01665	COG4187	Peptidase family M20/M25/M40
EXW56_RS01695	COG2205	protein histidine kinase activity
EXW56_RS01720	COG0697	spore germination
EXW56_RS01745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW56_RS01750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW56_RS01755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW56_RS01765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW56_RS01770	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW56_RS01780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW56_RS01790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW56_RS01795	COG0138	bifunctional purine biosynthesis protein purh
EXW56_RS01800	COG0151	Belongs to the GarS family
EXW56_RS01820	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW56_RS01825	COG0210	DNA helicase
EXW56_RS01830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW56_RS01835	COG4851	CamS sex pheromone cAM373 precursor
EXW56_RS01845	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS01850	COG1335	isochorismatase
EXW56_RS01860	COG2011	ABC-type metal ion transport system permease component
EXW56_RS01865	COG1464	Belongs to the NlpA lipoprotein family
EXW56_RS01880	COG0003	Pfam Anion-transporting ATPase
EXW56_RS01885	COG1846	Transcriptional regulator
EXW56_RS01890	COG4682	membrane
EXW56_RS01905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW56_RS01910	COG1597	lipid kinase activity
EXW56_RS01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS01940	COG2076	Multidrug Resistance protein
EXW56_RS01950	COG2309	aminopeptidase activity
EXW56_RS01965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW56_RS01980	COG5002	protein histidine kinase activity
EXW56_RS01985	COG4807	Protein conserved in bacteria
EXW56_RS02010	COG1757	Na H antiporter
EXW56_RS02015	COG1473	amidohydrolase
EXW56_RS02030	COG0450	alkyl hydroperoxide reductase
EXW56_RS02040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW56_RS02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS02060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS02065	COG0492	ferredoxin-NADP+ reductase activity
EXW56_RS02075	COG0166	Belongs to the GPI family
EXW56_RS02100	COG5002	protein histidine kinase activity
EXW56_RS02115	COG3541	Predicted nucleotidyltransferase
EXW56_RS02120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW56_RS02120	COG0723	plastoquinol--plastocyanin reductase activity
EXW56_RS02130	COG0765	amino acid transport
EXW56_RS02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS02140	COG1126	abc transporter atp-binding protein
EXW56_RS02145	COG0840	transmembrane signaling receptor activity
EXW56_RS02150	COG0277	FAD linked oxidase domain protein
EXW56_RS02155	COG0366	Alpha amylase catalytic
EXW56_RS02160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW56_RS02160	COG1263	PTS System
EXW56_RS02160	COG2190	(PTS) system
EXW56_RS02180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW56_RS02185	COG0352	thiamine-phosphate diphosphorylase activity
EXW56_RS02190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW56_RS02210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW56_RS02215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW56_RS02220	COG1116	anion transmembrane transporter activity
EXW56_RS02225	COG0488	(ABC) transporter
EXW56_RS02265	COG2270	Major facilitator Superfamily
EXW56_RS02295	COG2310	stress, protein
EXW56_RS02300	COG2310	stress, protein
EXW56_RS02305	COG2310	stress, protein
EXW56_RS02310	COG0861	Integral membrane protein TerC family
EXW56_RS02320	COG3853	Toxic anion resistance protein (TelA)
EXW56_RS02330	COG4840	Belongs to the UPF0435 family
EXW56_RS02335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW56_RS02345	COG1295	ribonuclease BN
EXW56_RS02350	COG2217	Heavy metal translocating P-type atpase
EXW56_RS02355	COG0697	spore germination
EXW56_RS02375	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS02390	COG3871	stress protein (general stress protein 26)
EXW56_RS02395	COG0387	Pfam Sodium calcium exchanger
EXW56_RS02405	COG0535	radical SAM domain protein
EXW56_RS02425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW56_RS02445	COG3829	transcription factor binding
EXW56_RS02455	COG0833	amino acid
EXW56_RS02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW56_RS02485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW56_RS02485	COG1263	PTS System
EXW56_RS02490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW56_RS02510	COG1215	transferase activity, transferring glycosyl groups
EXW56_RS02520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW56_RS02520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW56_RS02525	COG0463	Glycosyl transferase, family 2
EXW56_RS02540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW56_RS02545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW56_RS02560	COG1228	amidohydrolase
EXW56_RS02565	COG1090	epimerase
EXW56_RS02570	COG2137	regulation of response to DNA damage stimulus
EXW56_RS02595	COG1988	membrane-bound metal-dependent
EXW56_RS02600	COG1194	a g-specific adenine glycosylase
EXW56_RS02620	COG3557	Belongs to the UPF0374 family
EXW56_RS02625	COG1132	(ABC) transporter
EXW56_RS02630	COG4129	membrane
EXW56_RS02635	COG0067	glutamate synthase
EXW56_RS02635	COG0069	glutamate synthase activity
EXW56_RS02635	COG0070	glutamate synthase
EXW56_RS02640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW56_RS02645	COG4555	ABC transporter
EXW56_RS02665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW56_RS02670	COG0735	belongs to the Fur family
EXW56_RS02785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW56_RS02790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW56_RS02810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW56_RS02820	COG2766	serine protein kinase
EXW56_RS02825	COG2718	Belongs to the UPF0229 family
EXW56_RS02840	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW56_RS02845	COG2268	Band 7 protein
EXW56_RS02850	COG3290	protein histidine kinase activity
EXW56_RS02855	COG4565	transcriptional regulatory protein
EXW56_RS02860	COG2851	Citrate transporter
EXW56_RS02885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW56_RS02890	COG0745	RESPONSE REGULATOR receiver
EXW56_RS02895	COG5002	protein histidine kinase activity
EXW56_RS02905	COG4990	cell redox homeostasis
EXW56_RS02910	COG3290	protein histidine kinase activity
EXW56_RS02915	COG4565	transcriptional regulatory protein
EXW56_RS02920	COG3493	citrate carrier protein
EXW56_RS02925	COG0281	malic enzyme
EXW56_RS02935	COG0697	spore germination
EXW56_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS02950	COG5002	protein histidine kinase activity
EXW56_RS02955	COG0745	RESPONSE REGULATOR receiver
EXW56_RS02960	COG0456	acetyltransferase
EXW56_RS02965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW56_RS02970	COG3383	formate dehydrogenase (NAD+) activity
EXW56_RS02975	COG2427	Protein of unknown function (DUF1641)
EXW56_RS02990	COG0531	amino acid
EXW56_RS03000	COG0640	Transcriptional regulator
EXW56_RS03005	COG2217	Heavy metal translocating P-type atpase
EXW56_RS03010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW56_RS03025	COG3227	Zinc metalloprotease (Elastase)
EXW56_RS03045	COG2720	vancomycin resistance protein
EXW56_RS03050	COG1316	TRANSCRIPTIONal
EXW56_RS03055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS03060	COG0346	lactoylglutathione lyase activity
EXW56_RS03065	COG1253	flavin adenine dinucleotide binding
EXW56_RS03070	COG1027	Aspartate ammonia-lyase
EXW56_RS03075	COG1620	l-lactate permease
EXW56_RS03080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW56_RS03095	COG3104	oligopeptide transport
EXW56_RS03100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS03105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS03110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS03125	COG0156	8-amino-7-oxononanoate synthase activity
EXW56_RS03130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW56_RS03135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXW56_RS03145	COG4548	von Willebrand factor, type A
EXW56_RS03150	COG0714	Associated with various cellular activities
EXW56_RS03175	COG0531	amino acid
EXW56_RS03180	COG2188	Transcriptional regulator
EXW56_RS03185	COG1263	PTS System
EXW56_RS03185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW56_RS03190	COG0366	Alpha amylase catalytic
EXW56_RS03210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW56_RS03215	COG1115	amino acid carrier protein
EXW56_RS03220	COG1126	abc transporter atp-binding protein
EXW56_RS03225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS03230	COG0765	amino acid transport
EXW56_RS03235	COG0765	amino acid transport
EXW56_RS03240	COG0833	amino acid
EXW56_RS03265	COG2378	regulation of single-species biofilm formation
EXW56_RS03270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW56_RS03275	COG5002	protein histidine kinase activity
EXW56_RS03290	COG0659	secondary active sulfate transmembrane transporter activity
EXW56_RS03305	COG2271	Major facilitator Superfamily
EXW56_RS03310	COG1846	Transcriptional regulator
EXW56_RS03315	COG0477	Major facilitator Superfamily
EXW56_RS03320	COG1609	Transcriptional regulator
EXW56_RS03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW56_RS03330	COG1869	D-ribose catabolic process
EXW56_RS03340	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW56_RS03345	COG1879	ABC-type sugar transport system periplasmic component
EXW56_RS03375	COG1063	alcohol dehydrogenase
EXW56_RS03425	COG0840	transmembrane signaling receptor activity
EXW56_RS03430	COG3583	domain protein
EXW56_RS03430	COG3584	3D domain protein
EXW56_RS03435	COG1476	TRANSCRIPTIONal
EXW56_RS03455	COG3104	oligopeptide transport
EXW56_RS03460	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS03475	COG1113	amino acid transport
EXW56_RS03480	COG2252	PERMEase
EXW56_RS03495	COG2153	protein acetylation
EXW56_RS03505	COG0475	glutathione-regulated potassium exporter activity
EXW56_RS03505	COG0569	domain protein
EXW56_RS03515	COG1845	cytochrome c oxidase, subunit III
EXW56_RS03520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW56_RS03525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXW56_RS03530	COG0833	amino acid
EXW56_RS03535	COG4990	cell redox homeostasis
EXW56_RS03550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW56_RS03555	COG0697	spore germination
EXW56_RS03560	COG0531	amino acid
EXW56_RS03575	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW56_RS03580	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW56_RS03590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW56_RS03595	COG0573	inorganic phosphate transmembrane transporter activity
EXW56_RS03600	COG0581	inorganic phosphate transmembrane transporter activity
EXW56_RS03610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW56_RS03655	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW56_RS03735	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW56_RS03750	COG4991	sh3 domain protein
EXW56_RS03750	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS03750	COG3103	Sh3 type 3 domain protein
EXW56_RS03755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW56_RS03760	COG1116	anion transmembrane transporter activity
EXW56_RS03765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW56_RS03770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW56_RS03775	COG0352	thiamine-phosphate diphosphorylase activity
EXW56_RS03780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW56_RS03785	COG2104	thiamine diphosphate biosynthetic process
EXW56_RS03790	COG2022	thiamine diphosphate biosynthetic process
EXW56_RS03795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW56_RS03800	COG0351	phosphomethylpyrimidine kinase
EXW56_RS03830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW56_RS03835	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW56_RS03840	COG2205	protein histidine kinase activity
EXW56_RS03875	COG1136	(ABC) transporter
EXW56_RS03885	COG2252	PERMEase
EXW56_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS03950	COG0778	Nitroreductase
EXW56_RS03955	COG2719	SpoVR family
EXW56_RS03980	COG1937	Protein conserved in bacteria
EXW56_RS03985	COG0425	Belongs to the sulfur carrier protein TusA family
EXW56_RS03985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW56_RS03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS03990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW56_RS03995	COG0425	Belongs to the sulfur carrier protein TusA family
EXW56_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW56_RS04005	COG2210	Belongs to the sulfur carrier protein TusA family
EXW56_RS04010	COG0730	response to heat
EXW56_RS04020	COG1316	TRANSCRIPTIONal
EXW56_RS04025	COG0604	alcohol dehydrogenase
EXW56_RS04030	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW56_RS04050	COG3711	transcriptional antiterminator
EXW56_RS04050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW56_RS04055	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW56_RS04060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS04085	COG1388	LysM domain
EXW56_RS04085	COG3584	3D domain protein
EXW56_RS04090	COG0577	efflux transmembrane transporter activity
EXW56_RS04095	COG1136	(ABC) transporter
EXW56_RS04105	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW56_RS04120	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS04125	COG3546	catalase activity
EXW56_RS04170	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS04200	COG0531	amino acid
EXW56_RS04205	COG0475	glutathione-regulated potassium exporter activity
EXW56_RS04215	COG1737	Transcriptional regulator
EXW56_RS04225	COG1263	PTS System
EXW56_RS04225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW56_RS04235	COG2259	Doxx family
EXW56_RS04260	COG1522	sequence-specific DNA binding
EXW56_RS04270	COG0300	oxidoreductase activity
EXW56_RS04285	COG2076	Multidrug Resistance protein
EXW56_RS04290	COG1309	transcriptional regulator
EXW56_RS04295	COG2814	Major facilitator Superfamily
EXW56_RS04300	COG1733	regulation of RNA biosynthetic process
EXW56_RS04310	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW56_RS04320	COG4533	DNA binding
EXW56_RS04325	COG2211	Major facilitator Superfamily
EXW56_RS04335	COG4473	ABC transporter
EXW56_RS04340	COG0531	amino acid
EXW56_RS04345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXW56_RS04350	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS04355	COG1132	(ABC) transporter
EXW56_RS04360	COG1132	(ABC) transporter
EXW56_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS04370	COG0765	amino acid transport
EXW56_RS04375	COG1126	abc transporter atp-binding protein
EXW56_RS04390	COG0189	ligase activity
EXW56_RS04400	COG4399	Belongs to the UPF0754 family
EXW56_RS04405	COG3679	Belongs to the UPF0342 family
EXW56_RS04410	COG0463	Glycosyl transferase, family 2
EXW56_RS04415	COG1216	Glycosyl transferase, family 2
EXW56_RS04420	COG2094	Belongs to the DNA glycosylase MPG family
EXW56_RS04425	COG0561	phosphatase activity
EXW56_RS04430	COG3409	Peptidoglycan-binding domain 1 protein
EXW56_RS04430	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW56_RS04450	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS04460	COG0789	Transcriptional regulator
EXW56_RS04460	COG4978	Transcriptional regulator
EXW56_RS04470	COG0659	secondary active sulfate transmembrane transporter activity
EXW56_RS04475	COG2244	polysaccharide biosynthetic process
EXW56_RS04495	COG1024	Enoyl-CoA hydratase
EXW56_RS04510	COG1363	Peptidase, m42
EXW56_RS04535	COG1113	amino acid transport
EXW56_RS04540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS04560	COG0579	oxidoreductase
EXW56_RS04565	COG2226	methyltransferase
EXW56_RS04570	COG3290	protein histidine kinase activity
EXW56_RS04570	COG3829	transcription factor binding
EXW56_RS04595	COG1160	GTP binding
EXW56_RS04605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW56_RS04630	COG0601	transmembrane transport
EXW56_RS04635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW56_RS04640	COG0444	Belongs to the ABC transporter superfamily
EXW56_RS04645	COG4608	Belongs to the ABC transporter superfamily
EXW56_RS04785	COG0514	ATP-dependent DNA helicase (RecQ)
EXW56_RS04790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW56_RS04810	COG0305	Participates in initiation and elongation during chromosome replication
EXW56_RS04840	COG0477	Major facilitator Superfamily
EXW56_RS04900	COG1183	phosphatidylcholine synthase activity
EXW56_RS04905	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS04920	COG2814	Major facilitator Superfamily
EXW56_RS04925	COG0640	Transcriptional regulator
EXW56_RS04955	COG2376	Dihydroxyacetone kinase
EXW56_RS04975	COG2376	Dihydroxyacetone kinase
EXW56_RS05000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW56_RS05000	COG2755	lipolytic protein G-D-S-L family
EXW56_RS05015	COG1335	isochorismatase
EXW56_RS05020	COG2373	Large extracellular alpha-helical protein
EXW56_RS05025	COG0596	Alpha beta hydrolase
EXW56_RS05055	COG2807	transmembrane transport
EXW56_RS05060	COG2186	Transcriptional regulator
EXW56_RS05075	COG4585	Histidine kinase
EXW56_RS05080	COG2197	response regulator
EXW56_RS05105	COG0420	3'-5' exonuclease activity
EXW56_RS05110	COG4717	serine-type aminopeptidase activity
EXW56_RS05115	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW56_RS05120	COG0346	lactoylglutathione lyase activity
EXW56_RS05125	COG2267	carboxylic ester hydrolase activity
EXW56_RS05140	COG3620	sequence-specific DNA binding
EXW56_RS05145	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW56_RS05150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW56_RS05155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW56_RS05160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW56_RS05175	COG1309	transcriptional regulator
EXW56_RS05180	COG2814	Major facilitator Superfamily
EXW56_RS05185	COG3973	AAA domain
EXW56_RS05220	COG0464	growth
EXW56_RS05250	COG0537	adenosine 5'-monophosphoramidase activity
EXW56_RS05255	COG1131	(ABC) transporter
EXW56_RS05260	COG4473	ABC transporter
EXW56_RS05285	COG4978	Transcriptional regulator
EXW56_RS05285	COG0789	Transcriptional regulator
EXW56_RS05305	COG0247	lactate metabolic process
EXW56_RS05310	COG1139	Iron-sulfur cluster binding protein
EXW56_RS05315	COG1556	Lactate utilization protein
EXW56_RS05330	COG3402	PFAM membrane-flanked domain
EXW56_RS05335	COG3428	Bacterial PH domain
EXW56_RS05360	COG3402	PFAM membrane-flanked domain
EXW56_RS05365	COG3428	Bacterial PH domain
EXW56_RS05370	COG2329	Antibiotic biosynthesis monooxygenase
EXW56_RS05375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW56_RS05385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW56_RS05390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW56_RS05425	COG1309	transcriptional regulator
EXW56_RS05430	COG1511	domain protein
EXW56_RS05435	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS05435	COG1216	Glycosyl transferase, family 2
EXW56_RS05465	COG2378	regulation of single-species biofilm formation
EXW56_RS05470	COG1609	Transcriptional regulator
EXW56_RS05480	COG1234	tRNA 3'-trailer cleavage
EXW56_RS05485	COG0095	Lipoate-protein ligase
EXW56_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS05505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW56_RS05510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW56_RS05515	COG4208	sulfate ABC transporter
EXW56_RS05525	COG3209	COG3209 Rhs family protein
EXW56_RS05605	COG1408	metallophosphoesterase
EXW56_RS05610	COG1078	dGTPase activity
EXW56_RS05625	COG1595	DNA-templated transcription, initiation
EXW56_RS05630	COG3708	Transcriptional regulator
EXW56_RS05630	COG2207	Transcriptional regulator
EXW56_RS05645	COG2205	protein histidine kinase activity
EXW56_RS05650	COG0745	RESPONSE REGULATOR receiver
EXW56_RS05675	COG0501	Belongs to the peptidase M48B family
EXW56_RS05680	COG0697	spore germination
EXW56_RS05695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW56_RS05700	COG2224	Isocitrate lyase
EXW56_RS05710	COG1278	Cold shock
EXW56_RS05720	COG4903	ComK protein
EXW56_RS05725	COG0398	Pfam SNARE associated Golgi protein
EXW56_RS05735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW56_RS05740	COG1074	ATP-dependent DNA helicase activity
EXW56_RS05795	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW56_RS05820	COG0367	asparagine synthase
EXW56_RS05835	COG0753	catalase activity
EXW56_RS05840	COG0004	ammonium transporteR
EXW56_RS05855	COG2996	Protein conserved in bacteria
EXW56_RS05910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW56_RS05920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS05935	COG0561	phosphatase activity
EXW56_RS05955	COG2267	carboxylic ester hydrolase activity
EXW56_RS05970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW56_RS05975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW56_RS05980	COG5504	Zn-dependent protease
EXW56_RS05995	COG0180	Tryptophanyl-tRNA synthetase
EXW56_RS06005	COG4166	transmembrane transport
EXW56_RS06010	COG0601	transmembrane transport
EXW56_RS06015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW56_RS06020	COG0444	Belongs to the ABC transporter superfamily
EXW56_RS06025	COG4608	Belongs to the ABC transporter superfamily
EXW56_RS06030	COG0534	Mate efflux family protein
EXW56_RS06035	COG4166	transmembrane transport
EXW56_RS06050	COG0861	Integral membrane protein TerC family
EXW56_RS06055	COG4862	establishment of competence for transformation
EXW56_RS06060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW56_RS06070	COG1164	Oligoendopeptidase f
EXW56_RS06085	COG2346	COG2346, Truncated hemoglobins
EXW56_RS06090	COG4116	CYTH
EXW56_RS06100	COG2357	RelA SpoT domain protein
EXW56_RS06110	COG0564	pseudouridine synthase activity
EXW56_RS06120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW56_RS06125	COG0772	Belongs to the SEDS family
EXW56_RS06135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW56_RS06150	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW56_RS06195	COG2153	protein acetylation
EXW56_RS06200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW56_RS06205	COG2382	esterase
EXW56_RS06230	COG5492	domain, Protein
EXW56_RS06235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW56_RS06245	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW56_RS06245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW56_RS06250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW56_RS06255	COG0134	indole-3-glycerol-phosphate synthase activity
EXW56_RS06260	COG0135	phosphoribosylanthranilate isomerase activity
EXW56_RS06265	COG0133	tryptophan synthase activity
EXW56_RS06270	COG0159	tryptophan synthase activity
EXW56_RS06280	COG1620	l-lactate permease
EXW56_RS06285	COG5634	Uncharacterized conserved protein (DUF2278)
EXW56_RS06315	COG2226	methyltransferase
EXW56_RS06335	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW56_RS06340	COG0567	Dehydrogenase, E1 component
EXW56_RS06345	COG1476	TRANSCRIPTIONal
EXW56_RS06390	COG1686	Belongs to the peptidase S11 family
EXW56_RS06395	COG0681	Belongs to the peptidase S26 family
EXW56_RS06430	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW56_RS06445	COG1177	transmembrane transport
EXW56_RS06450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW56_RS06460	COG2409	Drug exporters of the RND superfamily
EXW56_RS06470	COG0564	pseudouridine synthase activity
EXW56_RS06480	COG2340	Cysteine-rich secretory protein family
EXW56_RS06485	COG0247	lactate metabolic process
EXW56_RS06490	COG0277	FAD linked oxidase domain protein
EXW56_RS06495	COG3835	regulator
EXW56_RS06505	COG0745	RESPONSE REGULATOR receiver
EXW56_RS06510	COG5002	protein histidine kinase activity
EXW56_RS06510	COG3850	Histidine kinase
EXW56_RS06515	COG2186	Transcriptional regulator
EXW56_RS06530	COG1556	Lactate utilization protein
EXW56_RS06535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW56_RS06550	COG0583	DNA-binding transcription factor activity
EXW56_RS06560	COG0825	malonyl-CoA metabolic process
EXW56_RS06580	COG2116	formate transmembrane transporter activity
EXW56_RS06585	COG0861	Integral membrane protein TerC family
EXW56_RS06590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW56_RS06600	COG2030	dehydratase
EXW56_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS06625	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW56_RS06635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW56_RS06650	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW56_RS06655	COG3842	ATPase activity
EXW56_RS06665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW56_RS06670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW56_RS06680	COG1349	DNA-binding transcription factor activity
EXW56_RS06690	COG0235	Class ii aldolase
EXW56_RS06700	COG2861	carbohydrate metabolic process
EXW56_RS06710	COG3852	Histidine kinase
EXW56_RS06715	COG1846	Transcriptional regulator
EXW56_RS06725	COG2318	DinB family
EXW56_RS06730	COG5002	protein histidine kinase activity
EXW56_RS06740	COG0720	synthase
EXW56_RS06755	COG4873	Protein conserved in bacteria
EXW56_RS06770	COG0456	acetyltransferase
EXW56_RS06785	COG1780	Probably involved in ribonucleotide reductase function
EXW56_RS06800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW56_RS06805	COG0531	amino acid
EXW56_RS06820	COG2204	response regulator
EXW56_RS06825	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS06835	COG1725	Transcriptional regulator
EXW56_RS06840	COG1131	(ABC) transporter
EXW56_RS06850	COG1131	(ABC) transporter
EXW56_RS06855	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW56_RS06860	COG1266	CAAX protease self-immunity
EXW56_RS06870	COG1522	sequence-specific DNA binding
EXW56_RS06880	COG1335	isochorismatase
EXW56_RS06890	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW56_RS06895	COG2070	2-Nitropropane dioxygenase
EXW56_RS06900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW56_RS06905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW56_RS06910	COG1696	Membrane protein involved in D-alanine export
EXW56_RS06935	COG0716	FMN binding
EXW56_RS06950	COG3173	Aminoglycoside phosphotransferase
EXW56_RS06970	COG0534	Mate efflux family protein
EXW56_RS06995	COG1846	Transcriptional regulator
EXW56_RS07010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW56_RS07020	COG3874	Sporulation protein YtfJ
EXW56_RS07040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS07045	COG0028	Belongs to the TPP enzyme family
EXW56_RS07050	COG0440	acetolactate synthase activity
EXW56_RS07060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW56_RS07080	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW56_RS07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW56_RS07095	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW56_RS07100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW56_RS07105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW56_RS07110	COG0107	imidazoleglycerol-phosphate synthase activity
EXW56_RS07125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW56_RS07140	COG1183	phosphatidylcholine synthase activity
EXW56_RS07145	COG1368	sulfuric ester hydrolase activity
EXW56_RS07155	COG0019	diaminopimelate decarboxylase activity
EXW56_RS07170	COG2046	Belongs to the sulfate adenylyltransferase family
EXW56_RS07175	COG0529	Catalyzes the synthesis of activated sulfate
EXW56_RS07180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW56_RS07200	COG1648	precorrin-2 dehydrogenase activity
EXW56_RS07205	COG0733	neurotransmitter:sodium symporter activity
EXW56_RS07230	COG1757	Na H antiporter
EXW56_RS07245	COG4758	membrane
EXW56_RS07250	COG4585	Histidine kinase
EXW56_RS07255	COG2197	response regulator
EXW56_RS07265	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS07315	COG0730	response to heat
EXW56_RS07320	COG0306	phosphate transporter
EXW56_RS07325	COG1392	Phosphate transport regulator
EXW56_RS07330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW56_RS07345	COG3852	Histidine kinase
EXW56_RS07350	COG1801	Protein of unknown function DUF72
EXW56_RS07360	COG0582	viral genome integration into host DNA
EXW56_RS07365	COG5002	protein histidine kinase activity
EXW56_RS07380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW56_RS07380	COG0392	lysyltransferase activity
EXW56_RS07395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW56_RS07400	COG1686	Belongs to the peptidase S11 family
EXW56_RS07405	COG2715	membrane protein required for spore maturation
EXW56_RS07410	COG0700	Nucleoside recognition
EXW56_RS07415	COG1187	pseudouridine synthase activity
EXW56_RS07425	COG1333	cytochrome c biogenesis protein
EXW56_RS07430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW56_RS07435	COG0745	RESPONSE REGULATOR receiver
EXW56_RS07440	COG5002	protein histidine kinase activity
EXW56_RS07445	COG2096	Adenosyltransferase
EXW56_RS07450	COG4942	peptidase
EXW56_RS07460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW56_RS07465	COG1141	Ferredoxin
EXW56_RS07470	COG4955	Helix-turn-helix domain
EXW56_RS07475	COG0514	ATP-dependent DNA helicase (RecQ)
EXW56_RS07480	COG1266	CAAX protease self-immunity
EXW56_RS07490	COG1408	metallophosphoesterase
EXW56_RS07505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW56_RS07520	COG0492	ferredoxin-NADP+ reductase activity
EXW56_RS07525	COG0252	asparaginase activity
EXW56_RS07535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW56_RS07545	COG1304	FMN binding
EXW56_RS07580	COG1160	GTP binding
EXW56_RS07605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW56_RS07620	COG0142	geranyltranstransferase activity
EXW56_RS07625	COG2226	methyltransferase
EXW56_RS07630	COG0142	geranyltranstransferase activity
EXW56_RS07645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW56_RS07655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW56_RS07660	COG0457	Tetratricopeptide repeat
EXW56_RS07665	COG5582	Belongs to the UPF0302 family
EXW56_RS07680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW56_RS07685	COG2010	Cytochrome c
EXW56_RS07685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW56_RS07695	COG4347	Protein of unknown function (DUF1405)
EXW56_RS07710	COG2738	Putative neutral zinc metallopeptidase
EXW56_RS07720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS07725	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW56_RS07730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW56_RS07735	COG1803	Methylglyoxal synthase
EXW56_RS07740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW56_RS07745	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS07750	COG0617	tRNA 3'-terminal CCA addition
EXW56_RS07760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW56_RS07765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW56_RS07775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW56_RS07775	COG1199	ATP-dependent helicase activity
EXW56_RS07795	COG3935	DnaD domain protein
EXW56_RS07800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW56_RS07810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW56_RS07810	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW56_RS07815	COG3331	DNA recombination
EXW56_RS07850	COG4474	Belongs to the UPF0398 family
EXW56_RS07855	COG3599	regulation of cell shape
EXW56_RS07865	COG0116	Belongs to the methyltransferase superfamily
EXW56_RS07875	COG1199	ATP-dependent helicase activity
EXW56_RS07880	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW56_RS07890	COG0024	Methionine aminopeptidase
EXW56_RS07900	COG2233	PERMEase
EXW56_RS07905	COG2311	Membrane
EXW56_RS07915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW56_RS07925	COG0456	acetyltransferase
EXW56_RS07935	COG2897	thiosulfate sulfurtransferase activity
EXW56_RS07975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW56_RS07995	COG0454	-acetyltransferase
EXW56_RS08015	COG0328	RNA-DNA hybrid ribonuclease activity
EXW56_RS08050	COG3403	YqcI/YcgG family
EXW56_RS08055	COG1280	lysine exporter protein (LysE YggA)
EXW56_RS08070	COG3162	membrane
EXW56_RS08075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW56_RS08080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW56_RS08090	COG0475	glutathione-regulated potassium exporter activity
EXW56_RS08095	COG0789	Transcriptional regulator
EXW56_RS08095	COG4978	Transcriptional regulator
EXW56_RS08100	COG0534	Mate efflux family protein
EXW56_RS08105	COG2323	membrane
EXW56_RS08110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW56_RS08130	COG1609	Transcriptional regulator
EXW56_RS08140	COG1175	transmembrane transport
EXW56_RS08145	COG0395	ABC-type sugar transport system, permease component
EXW56_RS08150	COG5578	integral membrane protein
EXW56_RS08160	COG1486	melibiose metabolic process
EXW56_RS08170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EXW56_RS08175	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EXW56_RS08180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW56_RS08215	COG1923	regulation of RNA biosynthetic process
EXW56_RS08225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW56_RS08230	COG1360	Flagellar Motor Protein
EXW56_RS08235	COG2201	protein-glutamate methylesterase activity
EXW56_RS08240	COG2198	Histidine kinase
EXW56_RS08240	COG0643	Histidine kinase
EXW56_RS08245	COG1776	CheC inhibitor of MCP methylation
EXW56_RS08245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW56_RS08260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW56_RS08280	COG1256	bacterial-type flagellum assembly
EXW56_RS08285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW56_RS08305	COG1815	bacterial-type flagellum-dependent cell motility
EXW56_RS08310	COG1558	bacterial-type flagellum-dependent cell motility
EXW56_RS08320	COG1766	The M ring may be actively involved in energy transduction
EXW56_RS08325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW56_RS08335	COG1157	protein secretion by the type III secretion system
EXW56_RS08355	COG1749	Flagellar hook protein flgE
EXW56_RS08370	COG0784	Response regulator, receiver
EXW56_RS08370	COG0835	chemotaxis
EXW56_RS08380	COG0861	Integral membrane protein TerC family
EXW56_RS08390	COG3383	formate dehydrogenase (NAD+) activity
EXW56_RS08395	COG2427	Protein of unknown function (DUF1641)
EXW56_RS08400	COG5609	conserved protein (DUF2294)
EXW56_RS08405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW56_RS08415	COG2116	formate transmembrane transporter activity
EXW56_RS08420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW56_RS08425	COG0303	'Molybdopterin
EXW56_RS08430	COG0314	molybdopterin synthase activity
EXW56_RS08445	COG0489	protein tyrosine kinase activity
EXW56_RS08450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW56_RS08450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW56_RS08455	COG0741	lytic transglycosylase activity
EXW56_RS08465	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW56_RS08470	COG1776	CheC inhibitor of MCP methylation
EXW56_RS08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW56_RS08480	COG1338	Plays a role in the flagellum-specific transport system
EXW56_RS08485	COG1987	bacterial-type flagellum assembly
EXW56_RS08495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW56_RS08500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW56_RS08505	COG1419	protein localization to endoplasmic reticulum
EXW56_RS08510	COG4786	Flagellar basal body rod
EXW56_RS08545	COG0412	Dienelactone hydrolase
EXW56_RS08550	COG2329	Antibiotic biosynthesis monooxygenase
EXW56_RS08565	COG3764	Sortase (surface protein transpeptidase)
EXW56_RS08570	COG3764	Sortase (surface protein transpeptidase)
EXW56_RS08595	COG0583	DNA-binding transcription factor activity
EXW56_RS08600	COG3842	ATPase activity
EXW56_RS08660	COG1846	Transcriptional regulator
EXW56_RS08670	COG0367	asparagine synthase
EXW56_RS08700	COG1757	Na H antiporter
EXW56_RS08710	COG0277	FAD linked oxidase domain protein
EXW56_RS08730	COG0534	Mate efflux family protein
EXW56_RS08735	COG3340	Belongs to the peptidase S51 family
EXW56_RS08755	COG0785	Cytochrome C biogenesis protein
EXW56_RS08775	COG3048	D-serine ammonia-lyase activity
EXW56_RS08780	COG2733	membrane
EXW56_RS08815	COG1131	(ABC) transporter
EXW56_RS08835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW56_RS08845	COG0457	Tetratricopeptide repeat
EXW56_RS08855	COG3157	Type VI secretion system effector, Hcp
EXW56_RS08875	COG0528	UMP kinase activity
EXW56_RS08885	COG1027	Aspartate ammonia-lyase
EXW56_RS08890	COG0281	malic enzyme
EXW56_RS08895	COG4191	Histidine kinase
EXW56_RS08900	COG0784	Response regulator, receiver
EXW56_RS08905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW56_RS08915	COG2502	aspartate--ammonia ligase
EXW56_RS08950	COG2814	Major facilitator Superfamily
EXW56_RS08975	COG1695	Transcriptional regulator
EXW56_RS08990	COG0477	Major facilitator Superfamily
EXW56_RS09005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW56_RS09010	COG2223	nitrite transmembrane transporter activity
EXW56_RS09015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW56_RS09030	COG2244	polysaccharide biosynthetic process
EXW56_RS09035	COG0733	neurotransmitter:sodium symporter activity
EXW56_RS09045	COG5566	PFAM Mor transcription activator
EXW56_RS09050	COG2323	membrane
EXW56_RS09070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW56_RS09085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW56_RS09095	COG1811	Na channel or pump
EXW56_RS09105	COG2814	Major facilitator Superfamily
EXW56_RS09110	COG3384	dioxygenase
EXW56_RS09165	COG4166	transmembrane transport
EXW56_RS09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS09190	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW56_RS09195	COG1054	Belongs to the UPF0176 family
EXW56_RS09205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW56_RS09210	COG0531	amino acid
EXW56_RS09230	COG1280	lysine exporter protein (LysE YggA)
EXW56_RS09240	COG2390	Transcriptional regulator
EXW56_RS09245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW56_RS09250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS09255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW56_RS09270	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW56_RS09280	COG0006	proline dipeptidase activity
EXW56_RS09285	COG2132	Multicopper oxidase
EXW56_RS09295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW56_RS09305	COG0583	DNA-binding transcription factor activity
EXW56_RS09325	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS09335	COG2372	response to copper ion
EXW56_RS09335	COG1276	copper resistance
EXW56_RS09340	COG4549	nuclear export factor GLE1
EXW56_RS09345	COG0697	spore germination
EXW56_RS09350	COG0583	DNA-binding transcription factor activity
EXW56_RS09355	COG1959	2 iron, 2 sulfur cluster binding
EXW56_RS09360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW56_RS09365	COG0778	Nitroreductase
EXW56_RS09375	COG0628	permease
EXW56_RS09390	COG1231	oxidoreductase activity
EXW56_RS09395	COG0523	cobalamin synthesis protein
EXW56_RS09410	COG2030	dehydratase
EXW56_RS09415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW56_RS09430	COG0411	ABC transporter
EXW56_RS09450	COG0583	DNA-binding transcription factor activity
EXW56_RS09460	COG1942	4-Oxalocrotonate Tautomerase
EXW56_RS09475	COG0346	lactoylglutathione lyase activity
EXW56_RS09485	COG1271	oxidase subunit
EXW56_RS09490	COG1294	oxidase, subunit
EXW56_RS09495	COG4988	ABC transporter
EXW56_RS09500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW56_RS09530	COG1686	Belongs to the peptidase S11 family
EXW56_RS09545	COG0791	NLP P60 protein
EXW56_RS09545	COG1388	LysM domain
EXW56_RS09555	COG1132	(ABC) transporter
EXW56_RS09560	COG0745	RESPONSE REGULATOR receiver
EXW56_RS09565	COG5002	protein histidine kinase activity
EXW56_RS09575	COG0300	oxidoreductase activity
EXW56_RS09605	COG0460	homoserine dehydrogenase
EXW56_RS09615	COG0083	homoserine kinase activity
EXW56_RS09630	COG1316	TRANSCRIPTIONal
EXW56_RS09645	COG1285	pathogenesis
EXW56_RS09650	COG1247	-acetyltransferase
EXW56_RS09670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW56_RS09680	COG1082	Xylose isomerase domain protein TIM barrel
EXW56_RS09690	COG2814	Major facilitator Superfamily
EXW56_RS09695	COG1279	arginine transmembrane transporter activity
EXW56_RS09700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS09710	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW56_RS09745	COG0577	efflux transmembrane transporter activity
EXW56_RS09750	COG2002	toxin-antitoxin pair type II binding
EXW56_RS09755	COG1404	Belongs to the peptidase S8 family
EXW56_RS09765	COG3842	ATPase activity
EXW56_RS09770	COG2508	Transcriptional regulator
EXW56_RS09780	COG1653	transport
EXW56_RS09785	COG1175	transmembrane transport
EXW56_RS09790	COG0395	ABC-type sugar transport system, permease component
EXW56_RS09795	COG5426	von Willebrand factor, type A
EXW56_RS09805	COG1940	carbohydrate kinase activity
EXW56_RS09810	COG2222	sugar isomerase
EXW56_RS09820	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW56_RS09825	COG3684	Belongs to the aldolase LacD family
EXW56_RS09830	COG0366	Alpha amylase catalytic
EXW56_RS09835	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EXW56_RS09880	COG3949	Membrane
EXW56_RS09885	COG0783	Belongs to the Dps family
EXW56_RS09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW56_RS09910	COG1231	oxidoreductase activity
EXW56_RS09915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS09920	COG4989	oxidoreductase activity
EXW56_RS09925	COG0523	cobalamin synthesis protein
EXW56_RS09930	COG0456	acetyltransferase
EXW56_RS09935	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW56_RS09945	COG0702	epimerase
EXW56_RS09955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW56_RS09965	COG4166	transmembrane transport
EXW56_RS09970	COG0346	lactoylglutathione lyase activity
EXW56_RS09980	COG0406	alpha-ribazole phosphatase activity
EXW56_RS09990	COG5337	Spore coat protein CotH
EXW56_RS09995	COG1051	belongs to the nudix hydrolase family
EXW56_RS10000	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS10005	COG2244	polysaccharide biosynthetic process
EXW56_RS10015	COG0701	Predicted permease
EXW56_RS10020	COG3689	TIGRFAM TIGR03943 family protein
EXW56_RS10025	COG1607	acyl-coa hydrolase
EXW56_RS10035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW56_RS10050	COG0702	epimerase
EXW56_RS10055	COG2839	Protein conserved in bacteria
EXW56_RS10060	COG1253	flavin adenine dinucleotide binding
EXW56_RS10075	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS10080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW56_RS10095	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS10105	COG1876	peptidase activity
EXW56_RS10135	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS10145	COG0561	phosphatase activity
EXW56_RS10155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW56_RS10170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS10175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS10200	COG0456	acetyltransferase
EXW56_RS10235	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW56_RS10330	COG3874	Sporulation protein YtfJ
EXW56_RS10355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW56_RS10375	COG0346	lactoylglutathione lyase activity
EXW56_RS10385	COG0604	alcohol dehydrogenase
EXW56_RS10390	COG1595	DNA-templated transcription, initiation
EXW56_RS10405	COG0426	domain, Protein
EXW56_RS10405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW56_RS10415	COG0386	Belongs to the glutathione peroxidase family
EXW56_RS10420	COG1305	Transglutaminase-like
EXW56_RS10425	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW56_RS10430	COG0714	Associated with various cellular activities
EXW56_RS10445	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW56_RS10475	COG2359	stage V sporulation protein S
EXW56_RS10495	COG4824	toxin secretion phage lysis holin
EXW56_RS10515	COG0457	Tetratricopeptide repeat
EXW56_RS10550	COG1418	mRNA catabolic process
EXW56_RS10555	COG0488	(ABC) transporter
EXW56_RS10570	COG0629	single-stranded DNA binding
EXW56_RS10585	COG1413	lyase activity
EXW56_RS10600	COG2136	Putative SAM-dependent methyltransferase
EXW56_RS10600	COG2521	methyltransferase
EXW56_RS10605	COG0018	arginyl-trna synthetase
EXW56_RS10655	COG0017	Asparaginyl-tRNA synthetase
EXW56_RS10660	COG0733	neurotransmitter:sodium symporter activity
EXW56_RS10685	COG2610	gluconate transmembrane transporter activity
EXW56_RS10700	COG0456	acetyltransferase
EXW56_RS10705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW56_RS10710	COG1131	(ABC) transporter
EXW56_RS10715	COG4473	ABC transporter
EXW56_RS10725	COG0546	phosphoglycolate phosphatase activity
EXW56_RS10750	COG0671	phosphoesterase, PA-phosphatase related
EXW56_RS10770	COG0768	penicillin binding
EXW56_RS10785	COG1272	protein, Hemolysin III
EXW56_RS10790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW56_RS10795	COG0805	protein transport
EXW56_RS10805	COG1307	EDD domain protein, DegV family
EXW56_RS10810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW56_RS10815	COG1999	signal sequence binding
EXW56_RS10820	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW56_RS10825	COG0367	asparagine synthase
EXW56_RS10840	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW56_RS10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS10850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS10865	COG1335	isochorismatase
EXW56_RS10870	COG1051	belongs to the nudix hydrolase family
EXW56_RS10875	COG0668	transmembrane transport
EXW56_RS10880	COG2203	Gaf domain
EXW56_RS10880	COG4585	Histidine kinase
EXW56_RS10885	COG2197	response regulator
EXW56_RS10890	COG1737	Transcriptional regulator
EXW56_RS10895	COG1064	alcohol dehydrogenase
EXW56_RS10910	COG1070	Carbohydrate kinase
EXW56_RS10920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW56_RS10940	COG1125	glycine betaine transport
EXW56_RS10940	COG0517	IMP dehydrogenase activity
EXW56_RS10945	COG1174	glycine betaine transport
EXW56_RS10980	COG1253	flavin adenine dinucleotide binding
EXW56_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS10990	COG5506	Protein of unknown function (DUF1694)
EXW56_RS11005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW56_RS11010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW56_RS11015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW56_RS11020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW56_RS11025	COG0456	acetyltransferase
EXW56_RS11030	COG3829	transcription factor binding
EXW56_RS11035	COG1509	lysine 2,3-aminomutase activity
EXW56_RS11045	COG4479	Belongs to the UPF0346 family
EXW56_RS11070	COG4991	sh3 domain protein
EXW56_RS11070	COG3064	Membrane
EXW56_RS11070	COG0515	serine threonine protein kinase
EXW56_RS11080	COG0671	phosphoesterase, PA-phosphatase related
EXW56_RS11085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW56_RS11090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW56_RS11095	COG0582	viral genome integration into host DNA
EXW56_RS11115	COG5377	YqaJ viral recombinase family
EXW56_RS11155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW56_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS11205	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW56_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW56_RS11215	COG2814	Major facilitator Superfamily
EXW56_RS11225	COG0372	Belongs to the citrate synthase family
EXW56_RS11230	COG2079	MmgE PrpD family protein
EXW56_RS11235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW56_RS11240	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS11245	COG2084	Dehydrogenase
EXW56_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS11255	COG1280	lysine exporter protein (LysE YggA)
EXW56_RS11260	COG1024	Enoyl-CoA hydratase
EXW56_RS11275	COG0420	3'-5' exonuclease activity
EXW56_RS11300	COG2223	nitrite transmembrane transporter activity
EXW56_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS11315	COG1169	isochorismate synthase
EXW56_RS11320	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW56_RS11325	COG1535	isochorismatase
EXW56_RS11325	COG3433	isochorismatase activity
EXW56_RS11330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW56_RS11335	COG3251	PFAM MbtH domain protein
EXW56_RS11340	COG2814	Major facilitator Superfamily
EXW56_RS11355	COG0776	regulation of translation
EXW56_RS11365	COG2318	DinB family
EXW56_RS11370	COG1115	amino acid carrier protein
EXW56_RS11385	COG2329	Antibiotic biosynthesis monooxygenase
EXW56_RS11395	COG1187	pseudouridine synthase activity
EXW56_RS11400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW56_RS11415	COG1136	(ABC) transporter
EXW56_RS11425	COG0596	Alpha beta hydrolase
EXW56_RS11445	COG0028	Belongs to the TPP enzyme family
EXW56_RS11455	COG2226	methyltransferase
EXW56_RS11475	COG1253	flavin adenine dinucleotide binding
EXW56_RS11495	COG2267	carboxylic ester hydrolase activity
EXW56_RS11515	COG1846	Transcriptional regulator
EXW56_RS11525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS11530	COG1309	transcriptional regulator
EXW56_RS11540	COG0697	spore germination
EXW56_RS11545	COG0531	amino acid
EXW56_RS11565	COG1247	-acetyltransferase
EXW56_RS11600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW56_RS11620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS11645	COG0561	phosphatase activity
EXW56_RS11655	COG0583	DNA-binding transcription factor activity
EXW56_RS11660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW56_RS11690	COG0583	DNA-binding transcription factor activity
EXW56_RS11695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW56_RS11700	COG2258	MOSC domain
EXW56_RS11715	COG1132	(ABC) transporter
EXW56_RS11720	COG1132	(ABC) transporter
EXW56_RS11725	COG0582	viral genome integration into host DNA
EXW56_RS11735	COG0189	ligase activity
EXW56_RS11755	COG1396	sequence-specific DNA binding
EXW56_RS11845	COG0500	methyltransferase
EXW56_RS11845	COG3615	Tellurite resistance protein tehB
EXW56_RS11855	COG0693	protein deglycase activity
EXW56_RS11865	COG0588	phosphoglycerate mutase activity
EXW56_RS11885	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW56_RS11910	COG1686	Belongs to the peptidase S11 family
EXW56_RS11955	COG0768	penicillin binding
EXW56_RS11960	COG1595	DNA-templated transcription, initiation
EXW56_RS11970	COG0768	penicillin binding
EXW56_RS11975	COG0768	penicillin binding
EXW56_RS11995	COG0697	spore germination
EXW56_RS12010	COG1131	(ABC) transporter
EXW56_RS12020	COG1309	transcriptional regulator
EXW56_RS12025	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS12030	COG0439	Biotin carboxylase
EXW56_RS12035	COG0511	ligase activity, forming carbon-carbon bonds
EXW56_RS12040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW56_RS12045	COG1024	Enoyl-CoA hydratase
EXW56_RS12050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW56_RS12055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW56_RS12115	COG1686	Belongs to the peptidase S11 family
EXW56_RS12150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW56_RS12180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW56_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS12210	COG1733	regulation of RNA biosynthetic process
EXW56_RS12235	COG1309	transcriptional regulator
EXW56_RS12265	COG0697	spore germination
EXW56_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS12300	COG2323	membrane
EXW56_RS12305	COG2132	Multicopper oxidase
EXW56_RS12320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS12325	COG0697	spore germination
EXW56_RS12330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW56_RS12335	COG0201	protein transport
EXW56_RS12345	COG0737	Belongs to the 5'-nucleotidase family
EXW56_RS12350	COG1073	alpha beta
EXW56_RS12360	COG0577	efflux transmembrane transporter activity
EXW56_RS12365	COG1136	(ABC) transporter
EXW56_RS12380	COG5002	protein histidine kinase activity
EXW56_RS12385	COG0745	RESPONSE REGULATOR receiver
EXW56_RS12390	COG1011	Hydrolase
EXW56_RS12415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW56_RS12420	COG1183	phosphatidylcholine synthase activity
EXW56_RS12425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW56_RS12440	COG1132	(ABC) transporter
EXW56_RS12455	COG3961	Belongs to the TPP enzyme family
EXW56_RS12475	COG0322	excinuclease ABC activity
EXW56_RS12500	COG2318	DinB family
EXW56_RS12515	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW56_RS12550	COG0406	alpha-ribazole phosphatase activity
EXW56_RS12575	COG0592	DNA-directed DNA polymerase activity
EXW56_RS12590	COG2223	nitrite transmembrane transporter activity
EXW56_RS12600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW56_RS12610	COG0494	nUDIX hydrolase
EXW56_RS12640	COG0584	glycerophosphoryl diester phosphodiesterase
EXW56_RS12655	COG2814	Major facilitator Superfamily
EXW56_RS12705	COG0768	penicillin binding
EXW56_RS12710	COG0671	phosphoesterase, PA-phosphatase related
EXW56_RS12715	COG0604	alcohol dehydrogenase
EXW56_RS12720	COG5002	protein histidine kinase activity
EXW56_RS12725	COG0745	RESPONSE REGULATOR receiver
EXW56_RS12735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW56_RS12745	COG2205	protein histidine kinase activity
EXW56_RS12765	COG4720	Psort location CytoplasmicMembrane, score
EXW56_RS12770	COG1794	racemase activity, acting on amino acids and derivatives
EXW56_RS12775	COG1819	glycosyl
EXW56_RS12785	COG0768	penicillin binding
EXW56_RS12790	COG5002	protein histidine kinase activity
EXW56_RS12795	COG0561	phosphatase activity
EXW56_RS12830	COG2124	cytochrome p450
EXW56_RS12860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW56_RS12870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS12875	COG0460	homoserine dehydrogenase
EXW56_RS12895	COG0577	efflux transmembrane transporter activity
EXW56_RS12900	COG1136	(ABC) transporter
EXW56_RS12915	COG0488	(ABC) transporter
EXW56_RS12920	COG0667	Aldo Keto reductase
EXW56_RS12925	COG0583	DNA-binding transcription factor activity
EXW56_RS12930	COG2205	protein histidine kinase activity
EXW56_RS12935	COG0745	RESPONSE REGULATOR receiver
EXW56_RS12945	COG3773	Cell wall hydrolase
EXW56_RS12950	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW56_RS12960	COG3386	PFAM SMP-30 Gluconolaconase
EXW56_RS12970	COG0604	alcohol dehydrogenase
EXW56_RS13000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS13015	COG2959	enzyme of heme biosynthesis
EXW56_RS13040	COG3483	tryptophan 2,3-dioxygenase activity
EXW56_RS13050	COG3844	kynureninase activity
EXW56_RS13055	COG1309	transcriptional regulator
EXW56_RS13070	COG3284	Transcriptional regulator
EXW56_RS13090	COG1349	DNA-binding transcription factor activity
EXW56_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS13155	COG4176	ABC-type proline glycine betaine transport system permease component
EXW56_RS13160	COG4175	Glycine betaine
EXW56_RS13160	COG0517	IMP dehydrogenase activity
EXW56_RS13185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW56_RS13190	COG2153	protein acetylation
EXW56_RS13195	COG1132	(ABC) transporter
EXW56_RS13200	COG1819	glycosyl
EXW56_RS13220	COG2205	protein histidine kinase activity
EXW56_RS13225	COG2315	Protein conserved in bacteria
EXW56_RS13280	COG3973	AAA domain
EXW56_RS13285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW56_RS13305	COG0514	ATP-dependent DNA helicase (RecQ)
EXW56_RS13335	COG4637	Psort location Cytoplasmic, score
EXW56_RS13345	COG1227	inorganic diphosphatase activity
EXW56_RS13350	COG2318	DinB family
EXW56_RS13365	COG1162	GTPase activity
EXW56_RS13370	COG1115	amino acid carrier protein
EXW56_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS13380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW56_RS13390	COG3938	Belongs to the proline racemase family
EXW56_RS13395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW56_RS13435	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS13450	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW56_RS13455	COG4166	transmembrane transport
EXW56_RS13465	COG4948	Mandelate Racemase Muconate Lactonizing
EXW56_RS13480	COG0667	Aldo Keto reductase
EXW56_RS13525	COG2936	dipeptidyl-peptidase activity
EXW56_RS13530	COG5002	protein histidine kinase activity
EXW56_RS13535	COG0745	RESPONSE REGULATOR receiver
EXW56_RS13575	COG1164	Oligoendopeptidase f
EXW56_RS13600	COG1307	EDD domain protein, DegV family
EXW56_RS13635	COG2814	Major facilitator Superfamily
EXW56_RS13645	COG1664	Polymer-forming cytoskeletal
EXW56_RS13650	COG0789	Transcriptional regulator
EXW56_RS13655	COG4533	DNA binding
EXW56_RS13660	COG2814	Major facilitator Superfamily
EXW56_RS13660	COG0477	Major facilitator Superfamily
EXW56_RS13675	COG2261	transglycosylase associated protein
EXW56_RS13690	COG2226	methyltransferase
EXW56_RS13725	COG0436	Aminotransferase
EXW56_RS13730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW56_RS13740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW56_RS13755	COG1131	(ABC) transporter
EXW56_RS13795	COG0628	permease
EXW56_RS13820	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW56_RS13835	COG0697	spore germination
EXW56_RS13855	COG4912	Dna alkylation repair
EXW56_RS13880	COG2814	Major facilitator Superfamily
EXW56_RS13885	COG1368	sulfuric ester hydrolase activity
EXW56_RS13890	COG0488	(ABC) transporter
EXW56_RS13895	COG2409	Drug exporters of the RND superfamily
EXW56_RS13895	COG1033	growth of symbiont in host cell
EXW56_RS13900	COG1309	transcriptional regulator
EXW56_RS13910	COG2153	protein acetylation
EXW56_RS13920	COG0287	Prephenate dehydrogenase
EXW56_RS13935	COG1605	Chorismate mutase
EXW56_RS13935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW56_RS13970	COG1388	LysM domain
EXW56_RS13970	COG3584	3D domain protein
EXW56_RS13980	COG0346	lactoylglutathione lyase activity
EXW56_RS13990	COG0277	FAD linked oxidase domain protein
EXW56_RS14010	COG2610	gluconate transmembrane transporter activity
EXW56_RS14015	COG1024	Enoyl-CoA hydratase
EXW56_RS14025	COG3290	protein histidine kinase activity
EXW56_RS14025	COG3829	transcription factor binding
EXW56_RS14035	COG0579	oxidoreductase
EXW56_RS14040	COG1879	ABC-type sugar transport system periplasmic component
EXW56_RS14050	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW56_RS14055	COG1129	ABC transporter
EXW56_RS14060	COG2390	Transcriptional regulator
EXW56_RS14065	COG1070	Carbohydrate kinase
EXW56_RS14080	COG2226	methyltransferase
EXW56_RS14105	COG0346	lactoylglutathione lyase activity
EXW56_RS14110	COG2329	Antibiotic biosynthesis monooxygenase
EXW56_RS14130	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW56_RS14135	COG2207	Transcriptional regulator
EXW56_RS14140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS14145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW56_RS14150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW56_RS14155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW56_RS14160	COG3239	Fatty acid desaturase
EXW56_RS14180	COG3842	ATPase activity
EXW56_RS14205	COG1175	transmembrane transport
EXW56_RS14210	COG1349	DNA-binding transcription factor activity
EXW56_RS14220	COG3655	Transcriptional regulator
EXW56_RS14235	COG4377	Putative membrane peptidase family (DUF2324)
EXW56_RS14245	COG3279	Response regulator of the LytR AlgR family
EXW56_RS14260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS14265	COG0346	lactoylglutathione lyase activity
EXW56_RS14295	COG0714	Associated with various cellular activities
EXW56_RS14315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW56_RS14320	COG0753	catalase activity
EXW56_RS14335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW56_RS14350	COG0714	Associated with various cellular activities
EXW56_RS14420	COG0778	Nitroreductase
EXW56_RS14425	COG1846	Transcriptional regulator
EXW56_RS14445	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW56_RS14455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW56_RS14460	COG0824	Thioesterase
EXW56_RS14465	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS14470	COG0183	Belongs to the thiolase family
EXW56_RS14475	COG1024	Enoyl-CoA hydratase
EXW56_RS14480	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW56_RS14485	COG2723	6-phospho-beta-galactosidase activity
EXW56_RS14490	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW56_RS14495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS14510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS14520	COG2508	Transcriptional regulator
EXW56_RS14525	COG2814	Major facilitator Superfamily
EXW56_RS14540	COG3831	ATPase activity
EXW56_RS14540	COG4884	unkown
EXW56_RS14560	COG2814	Major facilitator Superfamily
EXW56_RS14565	COG1136	(ABC) transporter
EXW56_RS14565	COG0577	efflux transmembrane transporter activity
EXW56_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS14585	COG1309	transcriptional regulator
EXW56_RS14605	COG0456	acetyltransferase
EXW56_RS14620	COG0697	spore germination
EXW56_RS14625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS14645	COG0642	Histidine kinase
EXW56_RS14650	COG0745	RESPONSE REGULATOR receiver
EXW56_RS14655	COG0596	Alpha beta hydrolase
EXW56_RS14695	COG0833	amino acid
EXW56_RS14705	COG4335	DNA alkylation repair
EXW56_RS14730	COG0768	penicillin binding
EXW56_RS14740	COG3104	oligopeptide transport
EXW56_RS14755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW56_RS14770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW56_RS14775	COG1984	allophanate hydrolase subunit 2
EXW56_RS14780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW56_RS14785	COG1414	Transcriptional regulator
EXW56_RS14800	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS14835	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW56_RS14860	COG3848	Pyruvate phosphate dikinase
EXW56_RS14860	COG0574	Belongs to the PEP-utilizing enzyme family
EXW56_RS14910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS14920	COG0798	PFAM Bile acid sodium symporter
EXW56_RS14925	COG0346	lactoylglutathione lyase activity
EXW56_RS14930	COG0640	Transcriptional regulator
EXW56_RS14945	COG0346	lactoylglutathione lyase activity
EXW56_RS15000	COG0745	RESPONSE REGULATOR receiver
EXW56_RS15005	COG3850	Histidine kinase
EXW56_RS15005	COG5002	protein histidine kinase activity
EXW56_RS15040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW56_RS15045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW56_RS15060	COG2226	methyltransferase
EXW56_RS15075	COG1690	Belongs to the RtcB family
EXW56_RS15100	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW56_RS15115	COG1136	(ABC) transporter
EXW56_RS15120	COG0577	efflux transmembrane transporter activity
EXW56_RS15135	COG3850	Histidine kinase
EXW56_RS15135	COG5002	protein histidine kinase activity
EXW56_RS15145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS15185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW56_RS15205	COG1595	DNA-templated transcription, initiation
EXW56_RS15250	COG2814	Major facilitator Superfamily
EXW56_RS15430	COG1876	peptidase activity
EXW56_RS15435	COG2843	Capsule synthesis protein
EXW56_RS15450	COG0477	Major facilitator Superfamily
EXW56_RS15465	COG1846	Transcriptional regulator
EXW56_RS15470	COG2814	Major facilitator Superfamily
EXW56_RS15485	COG0076	glutamate decarboxylase activity
EXW56_RS15500	COG0561	phosphatase activity
EXW56_RS15575	COG1696	Membrane protein involved in D-alanine export
EXW56_RS15610	COG1329	Transcriptional regulator
EXW56_RS15650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW56_RS15665	COG2155	Conserved Protein
EXW56_RS15805	COG4187	Peptidase family M20/M25/M40
EXW56_RS15810	COG1414	Transcriptional regulator
EXW56_RS15815	COG0833	amino acid
EXW56_RS15830	COG2031	fatty acid transporter
EXW56_RS15840	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW56_RS15890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW56_RS15895	COG2356	endonuclease I
EXW56_RS15900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW56_RS15905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW56_RS15915	COG2197	response regulator
EXW56_RS15935	COG1785	Belongs to the alkaline phosphatase family
EXW56_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS15965	COG1131	(ABC) transporter
EXW56_RS15985	COG0494	nUDIX hydrolase
EXW56_RS15995	COG1011	Hydrolase
EXW56_RS16000	COG2365	Tyrosine phosphatase family
EXW56_RS16030	COG0628	permease
EXW56_RS16050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW56_RS16055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW56_RS16065	COG1253	flavin adenine dinucleotide binding
EXW56_RS16070	COG0789	Transcriptional regulator
EXW56_RS16075	COG0697	spore germination
EXW56_RS16085	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW56_RS16090	COG3813	Protein conserved in bacteria
EXW56_RS16095	COG4702	Belongs to the UPF0303 family
EXW56_RS16105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS16120	COG0494	nUDIX hydrolase
EXW56_RS16125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW56_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS16145	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW56_RS16150	COG1733	regulation of RNA biosynthetic process
EXW56_RS16165	COG1191	sigma factor activity
EXW56_RS16210	COG0814	amino acid
EXW56_RS16235	COG1151	hydroxylamine reductase activity
EXW56_RS16240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS16265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW56_RS16275	COG2072	flavoprotein involved in K transport
EXW56_RS16325	COG1695	Transcriptional regulator
EXW56_RS16330	COG0604	alcohol dehydrogenase
EXW56_RS16335	COG1113	amino acid transport
EXW56_RS16355	COG5002	protein histidine kinase activity
EXW56_RS16360	COG0745	RESPONSE REGULATOR receiver
EXW56_RS16365	COG5002	protein histidine kinase activity
EXW56_RS16375	COG2814	Major facilitator Superfamily
EXW56_RS16385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW56_RS16390	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS16400	COG0534	Mate efflux family protein
EXW56_RS16405	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS16410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW56_RS16425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW56_RS16430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW56_RS16450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS16455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS16465	COG3739	integral membrane protein
EXW56_RS16485	COG0583	DNA-binding transcription factor activity
EXW56_RS16505	COG1193	negative regulation of DNA recombination
EXW56_RS16515	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW56_RS16520	COG1164	Oligoendopeptidase f
EXW56_RS16545	COG3781	membrane
EXW56_RS16560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW56_RS16585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW56_RS16590	COG0457	Tetratricopeptide repeat
EXW56_RS16605	COG2808	Putative FMN-binding domain
EXW56_RS16610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW56_RS16620	COG0277	FAD linked oxidase domain protein
EXW56_RS16645	COG2514	catechol 2,3-dioxygenase activity
EXW56_RS16650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS16655	COG1126	abc transporter atp-binding protein
EXW56_RS16660	COG0765	amino acid transport
EXW56_RS16665	COG2720	vancomycin resistance protein
EXW56_RS16690	COG0110	maltose O-acetyltransferase activity
EXW56_RS16700	COG1278	Cold shock
EXW56_RS16710	COG0716	FMN binding
EXW56_RS16720	COG1051	belongs to the nudix hydrolase family
EXW56_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS16750	COG0165	Argininosuccinate lyase
EXW56_RS16765	COG4145	pantothenate transmembrane transporter activity
EXW56_RS16775	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS16790	COG1657	PFAM Prenyltransferase squalene oxidase
EXW56_RS16795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW56_RS16800	COG2962	Rard protein
EXW56_RS16805	COG3326	Membrane
EXW56_RS16810	COG0531	amino acid
EXW56_RS16835	COG1737	Transcriptional regulator
EXW56_RS16840	COG2971	BadF BadG BcrA BcrD
EXW56_RS16850	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW56_RS16855	COG1486	melibiose metabolic process
EXW56_RS16865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS16890	COG2226	methyltransferase
EXW56_RS16895	COG4166	transmembrane transport
EXW56_RS16900	COG4166	transmembrane transport
EXW56_RS16905	COG4166	transmembrane transport
EXW56_RS16915	COG1131	(ABC) transporter
EXW56_RS16925	COG0673	inositol 2-dehydrogenase activity
EXW56_RS16930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW56_RS16935	COG0187	DNA topoisomerase II activity
EXW56_RS16940	COG1832	CoA-binding protein
EXW56_RS16945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW56_RS16950	COG0745	RESPONSE REGULATOR receiver
EXW56_RS16960	COG1328	CTP reductase activity
EXW56_RS16960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW56_RS16970	COG4841	protein insertion into membrane
EXW56_RS16975	COG0824	Thioesterase
EXW56_RS17000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW56_RS17015	COG1132	(ABC) transporter
EXW56_RS17020	COG1266	CAAX protease self-immunity
EXW56_RS17025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW56_RS17055	COG2211	Major facilitator Superfamily
EXW56_RS17065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW56_RS17080	COG0183	Belongs to the thiolase family
EXW56_RS17085	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS17090	COG1268	BioY protein
EXW56_RS17095	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS17135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS17145	COG5002	protein histidine kinase activity
EXW56_RS17155	COG0400	carboxylic ester hydrolase activity
EXW56_RS17165	COG0069	glutamate synthase activity
EXW56_RS17170	COG1902	pentaerythritol trinitrate reductase activity
EXW56_RS17175	COG1329	Transcriptional regulator
EXW56_RS17180	COG0010	Belongs to the arginase family
EXW56_RS17190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW56_RS17195	COG2986	histidine ammonia-lyase
EXW56_RS17205	COG2226	methyltransferase
EXW56_RS17230	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW56_RS17235	COG0785	Cytochrome C biogenesis protein
EXW56_RS17245	COG1473	amidohydrolase
EXW56_RS17255	COG1131	(ABC) transporter
EXW56_RS17270	COG0583	DNA-binding transcription factor activity
EXW56_RS17280	COG1346	cytolysis
EXW56_RS17315	COG1132	(ABC) transporter
EXW56_RS17320	COG1132	(ABC) transporter
EXW56_RS17325	COG3763	UPF0154 protein
EXW56_RS17340	COG3639	organic phosphonate transmembrane transporter activity
EXW56_RS17345	COG3639	organic phosphonate transmembrane transporter activity
EXW56_RS17355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS17360	COG0737	Belongs to the 5'-nucleotidase family
EXW56_RS17370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW56_RS17375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW56_RS17390	COG1695	Transcriptional regulator
EXW56_RS17395	COG1132	(ABC) transporter
EXW56_RS17430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW56_RS17435	COG0110	maltose O-acetyltransferase activity
EXW56_RS17440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW56_RS17450	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW56_RS17450	COG3420	alginic acid biosynthetic process
EXW56_RS17455	COG1442	glycosyl transferase family 8
EXW56_RS17455	COG1216	Glycosyl transferase, family 2
EXW56_RS17460	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS17490	COG1216	Glycosyl transferase, family 2
EXW56_RS17510	COG0463	Glycosyl transferase, family 2
EXW56_RS17510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW56_RS17515	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS17520	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS17525	COG1086	Polysaccharide biosynthesis protein
EXW56_RS17530	COG0489	protein tyrosine kinase activity
EXW56_RS17535	COG3944	biosynthesis protein
EXW56_RS17540	COG0174	glutamine synthetase
EXW56_RS17545	COG0789	Transcriptional regulator
EXW56_RS17550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW56_RS17555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW56_RS17560	COG2860	membrane
EXW56_RS17570	COG0464	growth
EXW56_RS17590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW56_RS17600	COG1388	LysM domain
EXW56_RS17600	COG3584	3D domain protein
EXW56_RS17605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW56_RS17605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW56_RS17605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW56_RS17610	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW56_RS17615	COG1349	DNA-binding transcription factor activity
EXW56_RS17620	COG1979	alcohol dehydrogenase
EXW56_RS17630	COG2322	membrane
EXW56_RS17640	COG1473	amidohydrolase
EXW56_RS17645	COG1408	metallophosphoesterase
EXW56_RS17650	COG2116	formate transmembrane transporter activity
EXW56_RS17665	COG2217	Heavy metal translocating P-type atpase
EXW56_RS17670	COG2608	mercury ion transmembrane transporter activity
EXW56_RS17675	COG1937	Protein conserved in bacteria
EXW56_RS17705	COG2819	hydrolase of the alpha beta superfamily
EXW56_RS17710	COG1120	ATPase activity
EXW56_RS17715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS17720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS17725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS17730	COG0708	Exodeoxyribonuclease III
EXW56_RS17735	COG2169	Transcriptional regulator
EXW56_RS17740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW56_RS17745	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW56_RS17750	COG2706	6-phosphogluconolactonase activity
EXW56_RS17755	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW56_RS17770	COG0346	lactoylglutathione lyase activity
EXW56_RS17775	COG3300	MHYT domain
EXW56_RS17775	COG5001	Diguanylate cyclase
EXW56_RS17810	COG1346	cytolysis
EXW56_RS17820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS17825	COG2945	thiolester hydrolase activity
EXW56_RS17825	COG0596	Alpha beta hydrolase
EXW56_RS17830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW56_RS17840	COG2188	Transcriptional regulator
EXW56_RS17845	COG2723	6-phospho-beta-galactosidase activity
EXW56_RS17855	COG3773	Cell wall hydrolase
EXW56_RS17865	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW56_RS17890	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW56_RS17895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW56_RS17900	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW56_RS17905	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW56_RS17905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW56_RS17915	COG2359	stage V sporulation protein S
EXW56_RS17920	COG1692	metallophosphoesterase
EXW56_RS17925	COG1418	mRNA catabolic process
EXW56_RS17930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW56_RS17935	COG1058	Belongs to the CinA family
EXW56_RS17935	COG1546	Belongs to the CinA family
EXW56_RS17940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW56_RS17945	COG1426	Protein conserved in bacteria
EXW56_RS17960	COG0300	oxidoreductase activity
EXW56_RS17965	COG0612	Peptidase, M16
EXW56_RS17970	COG0612	Peptidase, M16
EXW56_RS17975	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW56_RS17980	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW56_RS17985	COG3845	ABC transporter
EXW56_RS17990	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW56_RS17995	COG2188	Transcriptional regulator
EXW56_RS18005	COG1674	ftsk spoiiie
EXW56_RS18015	COG0740	serine-type endopeptidase activity
EXW56_RS18020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW56_RS18030	COG0527	aspartate kinase activity
EXW56_RS18035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW56_RS18040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW56_RS18045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW56_RS18050	COG1873	PFAM PRC-barrel domain
EXW56_RS18055	COG0612	Peptidase, M16
EXW56_RS18060	COG0726	polysaccharide deacetylase
EXW56_RS18065	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW56_RS18075	COG0196	riboflavin kinase activity
EXW56_RS18085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW56_RS18090	COG1550	Protein conserved in bacteria
EXW56_RS18095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW56_RS18100	COG1358	cellular component organization or biogenesis
EXW56_RS18105	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW56_RS18110	COG0195	Participates in both transcription termination and antitermination
EXW56_RS18125	COG0442	prolyl-tRNA aminoacylation
EXW56_RS18130	COG0750	zinc metalloprotease
EXW56_RS18140	COG4589	Belongs to the CDS family
EXW56_RS18150	COG0233	cytoplasmic translational termination
EXW56_RS18155	COG0528	UMP kinase activity
EXW56_RS18160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW56_RS18170	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW56_RS18175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW56_RS18180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW56_RS18185	COG4974	Belongs to the 'phage' integrase family
EXW56_RS18190	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW56_RS18195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW56_RS18200	COG0758	DNA mediated transformation
EXW56_RS18205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW56_RS18210	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW56_RS18215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW56_RS18230	COG0335	large ribosomal subunit rRNA binding
EXW56_RS18235	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW56_RS18240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW56_RS18245	COG1837	Belongs to the UPF0109 family
EXW56_RS18255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW56_RS18265	COG0552	protein localization to endoplasmic reticulum
EXW56_RS18270	COG1196	nuclear chromosome segregation
EXW56_RS18275	COG0571	ribonuclease III activity
EXW56_RS18280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW56_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS18290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW56_RS18295	COG0416	fatty acid biosynthetic process
EXW56_RS18305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW56_RS18310	COG1461	Dihydroxyacetone kinase
EXW56_RS18315	COG1302	Protein conserved in bacteria
EXW56_RS18330	COG1564	THIamine pyrophosphokinase
EXW56_RS18335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW56_RS18345	COG2815	serine threonine protein kinase
EXW56_RS18345	COG0515	serine threonine protein kinase
EXW56_RS18350	COG0631	protein serine/threonine phosphatase activity
EXW56_RS18355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW56_RS18360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW56_RS18360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW56_RS18365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW56_RS18370	COG0242	peptide deformylase activity
EXW56_RS18375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW56_RS18380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW56_RS18385	COG1758	RNA polymerase activity
EXW56_RS18400	COG1561	YicC-like family, N-terminal region
EXW56_RS18405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW56_RS18420	COG0006	proline dipeptidase activity
EXW56_RS18440	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW56_RS18465	COG0167	dihydroorotate dehydrogenase activity
EXW56_RS18470	COG0543	2 iron, 2 sulfur cluster binding
EXW56_RS18475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW56_RS18485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW56_RS18490	COG0540	Belongs to the ATCase OTCase family
EXW56_RS18500	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW56_RS18505	COG0564	pseudouridine synthase activity
EXW56_RS18525	COG3599	regulation of cell shape
EXW56_RS18530	COG2302	S4 RNA-binding domain
EXW56_RS18535	COG0762	integral membrane protein
EXW56_RS18540	COG1799	cell septum assembly
EXW56_RS18545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW56_RS18555	COG1873	PFAM PRC-barrel domain
EXW56_RS18560	COG1191	sigma factor activity
EXW56_RS18565	COG1191	sigma factor activity
EXW56_RS18575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW56_RS18580	COG0849	cell division
EXW56_RS18585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW56_RS18600	COG0772	Belongs to the SEDS family
EXW56_RS18605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW56_RS18610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW56_RS18615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW56_RS18620	COG0768	penicillin binding
EXW56_RS18625	COG0768	penicillin binding
EXW56_RS18635	COG0275	rRNA processing
EXW56_RS18640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW56_RS18645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW56_RS18650	COG0454	-acetyltransferase
EXW56_RS18660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW56_RS18665	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW56_RS18670	COG1323	Belongs to the UPF0348 family
EXW56_RS18675	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW56_RS18680	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW56_RS18685	COG3314	Sporulation integral membrane protein YlbJ
EXW56_RS18695	COG0742	ribosomal rna small subunit methyltransferase
EXW56_RS18705	COG4471	UPF0298 protein
EXW56_RS18710	COG3679	Belongs to the UPF0342 family
EXW56_RS18715	COG0406	alpha-ribazole phosphatase activity
EXW56_RS18730	COG2340	Cysteine-rich secretory protein family
EXW56_RS18740	COG3336	cytochrome c oxidase
EXW56_RS18765	COG0109	protoheme IX farnesyltransferase activity
EXW56_RS18770	COG1612	heme a metabolic process
EXW56_RS18775	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW56_RS18780	COG0772	Belongs to the SEDS family
EXW56_RS18785	COG4838	Belongs to the UPF0358 family
EXW56_RS18790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW56_RS18795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW56_RS18805	COG4896	Protein conserved in bacteria
EXW56_RS18820	COG1217	gtp-binding protein TYPA
EXW56_RS18830	COG0483	inositol monophosphate 1-phosphatase activity
EXW56_RS18840	COG4493	Belongs to the UPF0637 family
EXW56_RS18845	COG4476	Belongs to the UPF0223 family
EXW56_RS18850	COG1982	Orn Lys Arg decarboxylase major
EXW56_RS18905	COG0022	dehydrogenase e1 component
EXW56_RS18910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW56_RS18925	COG0561	phosphatase activity
EXW56_RS18930	COG5503	Protein of unknown function (DUF1447)
EXW56_RS18935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW56_RS18940	COG0569	domain protein
EXW56_RS18950	COG1473	amidohydrolase
EXW56_RS18955	COG2171	N-acyltransferase activity
EXW56_RS18960	COG0583	DNA-binding transcription factor activity
EXW56_RS18965	COG0517	IMP dehydrogenase activity
EXW56_RS18975	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW56_RS18985	COG4703	Protein of unknown function (DUF1797)
EXW56_RS19000	COG2200	EAL domain
EXW56_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS19010	COG1408	metallophosphoesterase
EXW56_RS19055	COG2814	Major facilitator Superfamily
EXW56_RS19065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW56_RS19075	COG3209	COG3209 Rhs family protein
EXW56_RS19085	COG2205	protein histidine kinase activity
EXW56_RS19095	COG0436	Aminotransferase
EXW56_RS19100	COG1609	Transcriptional regulator
EXW56_RS19105	COG3833	ABC-type maltose transport systems, permease component
EXW56_RS19110	COG1175	transmembrane transport
EXW56_RS19115	COG2182	Extracellular solute-binding protein
EXW56_RS19130	COG0366	Alpha amylase catalytic
EXW56_RS19135	COG3842	ATPase activity
EXW56_RS19180	COG0183	Belongs to the thiolase family
EXW56_RS19215	COG1695	Transcriptional regulator
EXW56_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS19230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW56_RS19235	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW56_RS19240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW56_RS19245	COG0436	Aminotransferase
EXW56_RS19250	COG1850	ribulose-bisphosphate carboxylase activity
EXW56_RS19255	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW56_RS19260	COG0235	Class ii aldolase
EXW56_RS19265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW56_RS19280	COG2084	Dehydrogenase
EXW56_RS19290	COG2199	diguanylate cyclase activity
EXW56_RS19295	COG0778	Nitroreductase
EXW56_RS19320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW56_RS19320	COG1263	PTS System
EXW56_RS19320	COG2190	(PTS) system
EXW56_RS19325	COG3711	transcriptional antiterminator
EXW56_RS19335	COG2188	Transcriptional regulator
EXW56_RS19340	COG0363	glucosamine-6-phosphate deaminase activity
EXW56_RS19345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW56_RS19355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW56_RS19360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW56_RS19370	COG1547	Domain of unknown function (DUF309)
EXW56_RS19380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW56_RS19385	COG4086	secreted protein
EXW56_RS19390	COG0561	phosphatase activity
EXW56_RS19395	COG0697	spore germination
EXW56_RS19410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW56_RS19450	COG1686	Belongs to the peptidase S11 family
EXW56_RS19455	COG1725	Transcriptional regulator
EXW56_RS19460	COG1131	(ABC) transporter
EXW56_RS19485	COG1846	Transcriptional regulator
EXW56_RS19500	COG0598	Magnesium transport protein CorA
EXW56_RS19525	COG4974	Belongs to the 'phage' integrase family
EXW56_RS19535	COG0735	belongs to the Fur family
EXW56_RS19540	COG1300	Membrane
EXW56_RS19560	COG0667	Aldo Keto reductase
EXW56_RS19565	COG0656	L-ascorbic acid biosynthetic process
EXW56_RS19570	COG0456	acetyltransferase
EXW56_RS19570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW56_RS19580	COG4085	toxin activity
EXW56_RS19580	COG0737	Belongs to the 5'-nucleotidase family
EXW56_RS19580	COG1525	nuclease
EXW56_RS19585	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW56_RS19595	COG0596	Alpha beta hydrolase
EXW56_RS19600	COG2056	Na+-H+ antiporter family
EXW56_RS19605	COG1609	Transcriptional regulator
EXW56_RS19610	COG0456	acetyltransferase
EXW56_RS19615	COG1073	alpha beta
EXW56_RS19630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW56_RS19630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW56_RS19635	COG0307	riboflavin synthase, alpha
EXW56_RS19640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW56_RS19640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW56_RS19655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW56_RS19665	COG1073	alpha beta
EXW56_RS19665	COG2226	methyltransferase
EXW56_RS19670	COG0156	8-amino-7-oxononanoate synthase activity
EXW56_RS19680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW56_RS19690	COG1757	Na H antiporter
EXW56_RS19695	COG0737	Belongs to the 5'-nucleotidase family
EXW56_RS19705	COG1522	sequence-specific DNA binding
EXW56_RS19725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW56_RS19730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW56_RS19740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW56_RS19750	COG0300	oxidoreductase activity
EXW56_RS19755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS19760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW56_RS19765	COG1760	l-serine dehydratase
EXW56_RS19770	COG1760	l-serine dehydratase
EXW56_RS19780	COG1234	tRNA 3'-trailer cleavage
EXW56_RS19810	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW56_RS19815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS19830	COG1376	ErfK ybiS ycfS ynhG family protein
EXW56_RS19835	COG4129	membrane
EXW56_RS19840	COG1126	abc transporter atp-binding protein
EXW56_RS19845	COG0765	amino acid transport
EXW56_RS19850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW56_RS19865	COG2816	NAD+ diphosphatase activity
EXW56_RS19870	COG2323	membrane
EXW56_RS19875	COG0772	Belongs to the SEDS family
EXW56_RS19880	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW56_RS19885	COG0022	dehydrogenase e1 component
EXW56_RS19890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW56_RS19895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW56_RS19900	COG3426	butyrate kinase activity
EXW56_RS19910	COG0280	phosphate acetyltransferase
EXW56_RS19915	COG3829	transcription factor binding
EXW56_RS19915	COG3290	protein histidine kinase activity
EXW56_RS19925	COG0584	glycerophosphoryl diester phosphodiesterase
EXW56_RS19930	COG3093	addiction module antidote protein HigA
EXW56_RS19940	COG0745	RESPONSE REGULATOR receiver
EXW56_RS19945	COG0750	zinc metalloprotease
EXW56_RS19950	COG0497	DNA recombination
EXW56_RS19955	COG1438	arginine binding
EXW56_RS19960	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW56_RS19965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW56_RS19970	COG0142	geranyltranstransferase activity
EXW56_RS19975	COG1722	exodeoxyribonuclease VII activity
EXW56_RS19985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW56_RS19990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW56_RS19995	COG1302	Protein conserved in bacteria
EXW56_RS20000	COG0439	Biotin carboxylase
EXW56_RS20005	COG0511	ligase activity, forming carbon-carbon bonds
EXW56_RS20050	COG3854	ATPases associated with a variety of cellular activities
EXW56_RS20070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW56_RS20075	COG0006	proline dipeptidase activity
EXW56_RS20090	COG3872	metal-dependent enzyme
EXW56_RS20100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW56_RS20135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW56_RS20145	COG1609	Transcriptional regulator
EXW56_RS20155	COG2076	Multidrug Resistance protein
EXW56_RS20160	COG2076	Multidrug Resistance protein
EXW56_RS20200	COG1725	Transcriptional regulator
EXW56_RS20215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW56_RS20220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW56_RS20225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW56_RS20230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW56_RS20260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW56_RS20285	COG4970	Tfp pilus assembly protein FimT
EXW56_RS20290	COG4537	Required for transformation and DNA binding
EXW56_RS20295	COG1459	type II secretion system
EXW56_RS20300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW56_RS20355	COG0646	methionine synthase
EXW56_RS20355	COG1410	methionine synthase
EXW56_RS20360	COG0646	methionine synthase
EXW56_RS20360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW56_RS20365	COG0626	cystathionine gamma-synthase activity
EXW56_RS20370	COG0626	cystathionine gamma-synthase activity
EXW56_RS20390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS20400	COG1940	carbohydrate kinase activity
EXW56_RS20405	COG4483	Protein conserved in bacteria
EXW56_RS20410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW56_RS20415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW56_RS20420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW56_RS20425	COG0704	Plays a role in the regulation of phosphate uptake
EXW56_RS20435	COG0581	inorganic phosphate transmembrane transporter activity
EXW56_RS20440	COG0573	inorganic phosphate transmembrane transporter activity
EXW56_RS20445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW56_RS20450	COG0768	penicillin binding
EXW56_RS20455	COG0477	Major facilitator Superfamily
EXW56_RS20460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW56_RS20480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW56_RS20485	COG0735	belongs to the Fur family
EXW56_RS20490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW56_RS20495	COG1121	(ABC) transporter
EXW56_RS20500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS20510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW56_RS20530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW56_RS20535	COG2384	SAM-dependent methyltransferase
EXW56_RS20540	COG2010	Cytochrome c
EXW56_RS20545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW56_RS20550	COG0358	DNA primase activity
EXW56_RS20560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW56_RS20565	COG0517	IMP dehydrogenase activity
EXW56_RS20570	COG1381	Involved in DNA repair and RecF pathway recombination
EXW56_RS20580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW56_RS20585	COG0295	cytidine deaminase activity
EXW56_RS20590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW56_RS20595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW56_RS20600	COG1480	7TM receptor with intracellular HD hydrolase
EXW56_RS20605	COG1702	phosphate starvation-inducible protein PhoH
EXW56_RS20620	COG1610	YqeY-like protein
EXW56_RS20625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW56_RS20635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW56_RS20640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW56_RS20650	COG0484	heat shock protein binding
EXW56_RS20655	COG0443	Heat shock 70 kDa protein
EXW56_RS20665	COG1420	regulation of RNA biosynthetic process
EXW56_RS20670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW56_RS20675	COG1733	regulation of RNA biosynthetic process
EXW56_RS20680	COG0481	GTPase activity
EXW56_RS20690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW56_RS20695	COG0268	Binds directly to 16S ribosomal RNA
EXW56_RS20700	COG1466	dna polymerase III delta subunit
EXW56_RS20710	COG2333	competence protein COMEC
EXW56_RS20710	COG0658	competence protein
EXW56_RS20715	COG2131	deaminase
EXW56_RS20720	COG1596	polysaccharide export
EXW56_RS20720	COG1555	photosystem II stabilization
EXW56_RS20725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW56_RS20730	COG2226	methyltransferase
EXW56_RS20735	COG0799	negative regulation of ribosome biogenesis
EXW56_RS20740	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW56_RS20745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW56_RS20750	COG1534	Rna-binding protein
EXW56_RS20755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW56_RS20760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW56_RS20765	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW56_RS20775	COG0688	phosphatidylethanolamine metabolic process
EXW56_RS20795	COG2357	RelA SpoT domain protein
EXW56_RS20805	COG1785	Belongs to the alkaline phosphatase family
EXW56_RS20815	COG2267	carboxylic ester hydrolase activity
EXW56_RS20850	COG1404	Belongs to the peptidase S8 family
EXW56_RS20855	COG3186	Phenylalanine-4-hydroxylase
EXW56_RS20865	COG2514	catechol 2,3-dioxygenase activity
EXW56_RS20870	COG2259	Doxx family
EXW56_RS20910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS20920	COG1454	alcohol dehydrogenase
EXW56_RS20920	COG1012	belongs to the aldehyde dehydrogenase family
EXW56_RS20925	COG0626	cystathionine gamma-synthase activity
EXW56_RS20930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW56_RS20935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW56_RS20940	COG2226	methyltransferase
EXW56_RS20955	COG0768	penicillin binding
EXW56_RS20960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW56_RS20965	COG0572	uridine kinase
EXW56_RS20970	COG0826	peptidase U32
EXW56_RS20975	COG0826	peptidase U32
EXW56_RS20980	COG4122	O-methyltransferase activity
EXW56_RS20985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW56_RS20995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW56_RS21005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW56_RS21010	COG0628	permease
EXW56_RS21030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW56_RS21040	COG0482	sulfurtransferase activity
EXW56_RS21045	COG1104	cysteine desulfurase activity
EXW56_RS21050	COG1959	2 iron, 2 sulfur cluster binding
EXW56_RS21055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW56_RS21065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW56_RS21070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW56_RS21085	COG1490	D-aminoacyl-tRNA deacylase activity
EXW56_RS21090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW56_RS21095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW56_RS21100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW56_RS21100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW56_RS21105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW56_RS21110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW56_RS21110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW56_RS21120	COG2244	polysaccharide biosynthetic process
EXW56_RS21125	COG2323	membrane
EXW56_RS21135	COG1862	Preprotein translocase
EXW56_RS21140	COG0343	queuine tRNA-ribosyltransferase activity
EXW56_RS21145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW56_RS21155	COG2255	four-way junction helicase activity
EXW56_RS21160	COG0632	four-way junction helicase activity
EXW56_RS21165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW56_RS21190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW56_RS21195	COG0157	Belongs to the NadC ModD family
EXW56_RS21200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW56_RS21205	COG1104	cysteine desulfurase activity
EXW56_RS21210	COG1827	regulation of RNA biosynthetic process
EXW56_RS21215	COG2258	MOSC domain
EXW56_RS21220	COG0077	Prephenate dehydratase
EXW56_RS21225	COG0577	efflux transmembrane transporter activity
EXW56_RS21230	COG0577	efflux transmembrane transporter activity
EXW56_RS21235	COG1136	(ABC) transporter
EXW56_RS21240	COG5002	protein histidine kinase activity
EXW56_RS21245	COG0745	RESPONSE REGULATOR receiver
EXW56_RS21250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW56_RS21255	COG3290	protein histidine kinase activity
EXW56_RS21265	COG2868	ribosomal protein
EXW56_RS21275	COG1530	ribonuclease E activity
EXW56_RS21280	COG1994	Peptidase M50
EXW56_RS21285	COG0739	heme binding
EXW56_RS21290	COG2894	cell division
EXW56_RS21295	COG0850	regulation of cytokinetic process
EXW56_RS21310	COG1077	Cell shape determining protein MreB Mrl
EXW56_RS21315	COG2003	Belongs to the UPF0758 family
EXW56_RS21320	COG0424	maF-like protein
EXW56_RS21330	COG0285	dihydrofolate synthase activity
EXW56_RS21345	COG1388	LysM domain
EXW56_RS21350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW56_RS21355	COG0113	porphobilinogen synthase activity
EXW56_RS21360	COG1587	Uroporphyrinogen-III synthase
EXW56_RS21365	COG0181	hydroxymethylbilane synthase activity
EXW56_RS21370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW56_RS21375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW56_RS21380	COG1846	Transcriptional regulator
EXW56_RS21385	COG1764	response to oxidative stress
EXW56_RS21390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW56_RS21400	COG0470	DNA polymerase III
EXW56_RS21400	COG1067	ATP-dependent peptidase activity
EXW56_RS21410	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW56_RS21445	COG0622	Phosphoesterase
EXW56_RS21455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW56_RS21460	COG5401	PFAM Sporulation and spore germination
EXW56_RS21470	COG2197	response regulator
EXW56_RS21475	COG2233	PERMEase
EXW56_RS21480	COG0402	S-adenosylhomocysteine deaminase activity
EXW56_RS21485	COG1983	PspC domain protein
EXW56_RS21490	COG1396	sequence-specific DNA binding
EXW56_RS21495	COG0697	spore germination
EXW56_RS21505	COG1959	2 iron, 2 sulfur cluster binding
EXW56_RS21510	COG1668	transmembrane transport
EXW56_RS21515	COG4152	abc transporter atp-binding protein
EXW56_RS21520	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW56_RS21525	COG1360	Flagellar Motor Protein
EXW56_RS21530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW56_RS21535	COG1876	peptidase activity
EXW56_RS21540	COG0824	Thioesterase
EXW56_RS21545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW56_RS21550	COG1053	succinate dehydrogenase
EXW56_RS21555	COG2009	succinate dehydrogenase
EXW56_RS21560	COG1719	4-vinyl reductase, 4VR
EXW56_RS21565	COG0322	excinuclease ABC activity
EXW56_RS21570	COG3118	belongs to the thioredoxin family
EXW56_RS21575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW56_RS21580	COG2086	electron transfer activity
EXW56_RS21585	COG1024	Enoyl-CoA hydratase
EXW56_RS21590	COG1309	transcriptional regulator
EXW56_RS21595	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS21635	COG1131	(ABC) transporter
EXW56_RS21640	COG2205	protein histidine kinase activity
EXW56_RS21645	COG0745	RESPONSE REGULATOR receiver
EXW56_RS21655	COG4895	conserved protein (DUF2196)
EXW56_RS21660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW56_RS21670	COG4509	Sortase family
EXW56_RS21675	COG1120	ATPase activity
EXW56_RS21690	COG5386	Cell surface protein
EXW56_RS21700	COG5386	Cell surface protein
EXW56_RS21705	COG1114	Component of the transport system for branched-chain amino acids
EXW56_RS21710	COG1187	pseudouridine synthase activity
EXW56_RS21715	COG1193	negative regulation of DNA recombination
EXW56_RS21720	COG1796	DNA polymerase
EXW56_RS21720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW56_RS21725	COG1286	toxin biosynthetic process
EXW56_RS21730	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW56_RS21735	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW56_RS21760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW56_RS21765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW56_RS21775	COG1418	mRNA catabolic process
EXW56_RS21795	COG2814	Major facilitator Superfamily
EXW56_RS21800	COG1566	PFAM secretion protein HlyD family protein
EXW56_RS21805	COG1309	transcriptional regulator
EXW56_RS21810	COG1363	Peptidase, m42
EXW56_RS21820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW56_RS21835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW56_RS21845	COG1484	DNA-dependent DNA replication
EXW56_RS21850	COG3611	Membrane attachment protein
EXW56_RS21855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW56_RS21860	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW56_RS21865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW56_RS21870	COG0237	dephospho-CoA kinase activity
EXW56_RS21875	COG1971	Probably functions as a manganese efflux pump
EXW56_RS21885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW56_RS21885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW56_RS21890	COG5002	protein histidine kinase activity
EXW56_RS21895	COG0745	RESPONSE REGULATOR receiver
EXW56_RS21915	COG0538	isocitrate dehydrogenase activity
EXW56_RS21920	COG0372	Belongs to the citrate synthase family
EXW56_RS21930	COG0628	permease
EXW56_RS21935	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW56_RS21945	COG0205	6-phosphofructokinase activity
EXW56_RS21960	COG1725	Transcriptional regulator
EXW56_RS21965	COG0281	malic enzyme
EXW56_RS21970	COG0587	DNA-directed DNA polymerase activity
EXW56_RS21985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW56_RS22000	COG4109	DRTGG domain
EXW56_RS22010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW56_RS22015	COG0006	proline dipeptidase activity
EXW56_RS22050	COG0662	Cupin 2, conserved barrel domain protein
EXW56_RS22060	COG1476	TRANSCRIPTIONal
EXW56_RS22075	COG1028	Short-chain dehydrogenase reductase Sdr
EXW56_RS22080	COG0589	response to stress
EXW56_RS22100	COG0165	Argininosuccinate lyase
EXW56_RS22105	COG0137	argininosuccinate synthase activity
EXW56_RS22120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS22140	COG0827	DNA restriction-modification system
EXW56_RS22145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW56_RS22150	COG3874	Sporulation protein YtfJ
EXW56_RS22165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW56_RS22175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW56_RS22190	COG1104	cysteine desulfurase activity
EXW56_RS22195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW56_RS22200	COG0583	DNA-binding transcription factor activity
EXW56_RS22205	COG0697	spore germination
EXW56_RS22210	COG1309	transcriptional regulator
EXW56_RS22215	COG1956	GAF domain-containing protein
EXW56_RS22220	COG0626	cystathionine gamma-synthase activity
EXW56_RS22225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW56_RS22235	COG5444	nuclease activity
EXW56_RS22270	COG1595	DNA-templated transcription, initiation
EXW56_RS22280	COG0110	maltose O-acetyltransferase activity
EXW56_RS22285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW56_RS22290	COG0454	-acetyltransferase
EXW56_RS22295	COG0517	IMP dehydrogenase activity
EXW56_RS22300	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW56_RS22315	COG0745	RESPONSE REGULATOR receiver
EXW56_RS22320	COG5002	protein histidine kinase activity
EXW56_RS22325	COG0666	response to abiotic stimulus
EXW56_RS22335	COG1970	mechanosensitive ion channel activity
EXW56_RS22355	COG1609	Transcriptional regulator
EXW56_RS22360	COG4851	CamS sex pheromone cAM373 precursor
EXW56_RS22375	COG2309	aminopeptidase activity
EXW56_RS22400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW56_RS22410	COG1674	ftsk spoiiie
EXW56_RS22425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW56_RS22430	COG4848	Belongs to the UPF0354 family
EXW56_RS22435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW56_RS22440	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW56_RS22445	COG1363	Peptidase, m42
EXW56_RS22455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS22460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW56_RS22470	COG0510	thiamine kinase activity
EXW56_RS22475	COG1523	belongs to the glycosyl hydrolase 13 family
EXW56_RS22485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW56_RS22490	COG1349	DNA-binding transcription factor activity
EXW56_RS22495	COG1187	pseudouridine synthase activity
EXW56_RS22500	COG2244	polysaccharide biosynthetic process
EXW56_RS22505	COG2081	HI0933 family
EXW56_RS22510	COG2814	Major facilitator Superfamily
EXW56_RS22520	COG3832	glyoxalase III activity
EXW56_RS22540	COG1329	Transcriptional regulator
EXW56_RS22555	COG0314	molybdopterin synthase activity
EXW56_RS22560	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW56_RS22565	COG0303	'Molybdopterin
EXW56_RS22570	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW56_RS22575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW56_RS22580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW56_RS22600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW56_RS22610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW56_RS22650	COG0495	leucyl-tRNA aminoacylation
EXW56_RS22655	COG2814	Major facilitator Superfamily
EXW56_RS22660	COG0475	glutathione-regulated potassium exporter activity
EXW56_RS22665	COG0490	domain, Protein
EXW56_RS22670	COG0582	viral genome integration into host DNA
EXW56_RS22685	COG1136	(ABC) transporter
EXW56_RS22700	COG1242	4 iron, 4 sulfur cluster binding
EXW56_RS22705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW56_RS22740	COG2267	carboxylic ester hydrolase activity
EXW56_RS22745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW56_RS22750	COG0671	phosphoesterase, PA-phosphatase related
EXW56_RS22755	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS22765	COG1404	Belongs to the peptidase S8 family
EXW56_RS22770	COG2197	response regulator
EXW56_RS22775	COG4585	Histidine kinase
EXW56_RS22800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW56_RS22805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW56_RS22840	COG5002	protein histidine kinase activity
EXW56_RS22845	COG3852	Histidine kinase
EXW56_RS22850	COG0753	catalase activity
EXW56_RS22855	COG2267	carboxylic ester hydrolase activity
EXW56_RS22860	COG1368	sulfuric ester hydrolase activity
EXW56_RS22870	COG4895	conserved protein (DUF2196)
EXW56_RS22885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW56_RS22890	COG1116	anion transmembrane transporter activity
EXW56_RS22895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW56_RS22910	COG0546	phosphoglycolate phosphatase activity
EXW56_RS22915	COG0494	nUDIX hydrolase
EXW56_RS22950	COG1854	S-ribosylhomocysteine lyase activity
EXW56_RS22960	COG0288	reversible hydration of carbon dioxide
EXW56_RS22965	COG1271	oxidase subunit
EXW56_RS22970	COG1294	oxidase, subunit
EXW56_RS22985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS23010	COG1842	Phage shock protein A
EXW56_RS23035	COG3859	Proton-coupled thiamine transporter YuaJ
EXW56_RS23040	COG5002	protein histidine kinase activity
EXW56_RS23045	COG0745	RESPONSE REGULATOR receiver
EXW56_RS23070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW56_RS23075	COG1597	lipid kinase activity
EXW56_RS23105	COG1136	(ABC) transporter
EXW56_RS23120	COG5002	protein histidine kinase activity
EXW56_RS23130	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS23140	COG0577	efflux transmembrane transporter activity
EXW56_RS23145	COG1136	(ABC) transporter
EXW56_RS23150	COG2207	Transcriptional regulator
EXW56_RS23150	COG3708	Transcriptional regulator
EXW56_RS23160	COG1131	(ABC) transporter
EXW56_RS23165	COG5658	integral membrane protein
EXW56_RS23170	COG5658	integral membrane protein
EXW56_RS23175	COG0640	Transcriptional regulator
EXW56_RS23180	COG0745	RESPONSE REGULATOR receiver
EXW56_RS23185	COG2205	protein histidine kinase activity
EXW56_RS23190	COG0577	efflux transmembrane transporter activity
EXW56_RS23195	COG0577	efflux transmembrane transporter activity
EXW56_RS23200	COG1136	(ABC) transporter
EXW56_RS23205	COG0577	efflux transmembrane transporter activity
EXW56_RS23215	COG2188	Transcriptional regulator
EXW56_RS23235	COG3964	amidohydrolase
EXW56_RS23260	COG4948	Mandelate Racemase Muconate Lactonizing
EXW56_RS23265	COG0318	PFAM AMP-dependent synthetase and ligase
EXW56_RS23270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW56_RS23275	COG0596	Alpha beta hydrolase
EXW56_RS23280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW56_RS23285	COG1169	isochorismate synthase
EXW56_RS23290	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW56_RS23295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW56_RS23300	COG1278	Cold shock
EXW56_RS23310	COG1051	belongs to the nudix hydrolase family
EXW56_RS23320	COG0058	SHG alpha-glucan phosphorylase activity
EXW56_RS23330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW56_RS23335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW56_RS23340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW56_RS23445	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW56_RS23480	COG1285	pathogenesis
EXW56_RS23485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW56_RS23495	COG0166	Belongs to the GPI family
EXW56_RS23500	COG2155	Conserved Protein
EXW56_RS23505	COG1098	S1 RNA binding domain
EXW56_RS23510	COG0436	Aminotransferase
EXW56_RS23515	COG1522	sequence-specific DNA binding
EXW56_RS23520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW56_RS23525	COG2267	carboxylic ester hydrolase activity
EXW56_RS23535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW56_RS23555	COG5018	Exonuclease
EXW56_RS23560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW56_RS23580	COG2050	protein possibly involved in aromatic compounds catabolism
EXW56_RS23590	COG1268	BioY protein
EXW56_RS23595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW56_RS23600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW56_RS23610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW56_RS23625	COG2076	Multidrug Resistance protein
EXW56_RS23630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EXW56_RS23635	COG3584	3D domain protein
EXW56_RS23650	COG1252	NADH dehydrogenase
EXW56_RS23655	COG0492	ferredoxin-NADP+ reductase activity
EXW56_RS23660	COG3708	Transcriptional regulator
EXW56_RS23675	COG1683	Conserved Protein
EXW56_RS23685	COG0316	Belongs to the HesB IscA family
EXW56_RS23690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW56_RS23695	COG4844	belongs to the
EXW56_RS23700	COG1252	NADH dehydrogenase
EXW56_RS23710	COG2274	protein secretion by the type I secretion system
EXW56_RS23715	COG0390	transport system, permease component
EXW56_RS23720	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW56_RS23740	COG4837	Protein of unknown function (DUF1462)
EXW56_RS23745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW56_RS23755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW56_RS23760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW56_RS23775	COG1136	(ABC) transporter
EXW56_RS23775	COG0577	efflux transmembrane transporter activity
EXW56_RS23780	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW56_RS23790	COG0647	UMP catabolic process
EXW56_RS23800	COG2445	Protein of unknown function DUF86
EXW56_RS23805	COG1494	fructose-1,6-bisphosphatase
EXW56_RS23825	COG4470	Protein conserved in bacteria
EXW56_RS23835	COG0789	Transcriptional regulator
EXW56_RS23840	COG4377	Putative membrane peptidase family (DUF2324)
EXW56_RS23865	COG0739	heme binding
EXW56_RS23875	COG3377	Domain of unknown function (DUF1805)
EXW56_RS23880	COG0737	Belongs to the 5'-nucleotidase family
EXW56_RS23885	COG0719	Fe-S assembly protein
EXW56_RS23890	COG0822	iron-sulfur transferase activity
EXW56_RS23895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW56_RS23900	COG0719	Fe-S assembly protein
EXW56_RS23905	COG0396	ATPase activity
EXW56_RS23910	COG1464	Belongs to the NlpA lipoprotein family
EXW56_RS23915	COG1464	Belongs to the NlpA lipoprotein family
EXW56_RS23920	COG2011	ABC-type metal ion transport system permease component
EXW56_RS23935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW56_RS23940	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW56_RS23945	COG0509	glycine decarboxylation via glycine cleavage system
EXW56_RS23950	COG1393	Belongs to the ArsC family
EXW56_RS23985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW56_RS23990	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS23995	COG0183	Belongs to the thiolase family
EXW56_RS24000	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW56_RS24000	COG1024	Enoyl-CoA hydratase
EXW56_RS24010	COG1686	Belongs to the peptidase S11 family
EXW56_RS24015	COG0506	proline dehydrogenase activity
EXW56_RS24025	COG0011	TIGRFAM Protein of
EXW56_RS24030	COG0840	transmembrane signaling receptor activity
EXW56_RS24045	COG2814	Major facilitator Superfamily
EXW56_RS24050	COG0531	amino acid
EXW56_RS24070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW56_RS24100	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS24110	COG1376	ErfK ybiS ycfS ynhG family protein
EXW56_RS24115	COG0745	RESPONSE REGULATOR receiver
EXW56_RS24120	COG5002	protein histidine kinase activity
EXW56_RS24130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW56_RS24140	COG0840	transmembrane signaling receptor activity
EXW56_RS24145	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW56_RS24150	COG3227	Zinc metalloprotease (Elastase)
EXW56_RS24170	COG0586	Pfam SNARE associated Golgi protein
EXW56_RS24175	COG0475	glutathione-regulated potassium exporter activity
EXW56_RS24180	COG0490	domain, Protein
EXW56_RS24185	COG1115	amino acid carrier protein
EXW56_RS24190	COG0783	Belongs to the Dps family
EXW56_RS24200	COG2318	DinB family
EXW56_RS24210	COG1611	Belongs to the LOG family
EXW56_RS24220	COG1528	Iron-storage protein
EXW56_RS24225	COG2311	Membrane
EXW56_RS24230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS24235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS24240	COG1115	amino acid carrier protein
EXW56_RS24245	COG1115	amino acid carrier protein
EXW56_RS24250	COG2910	NAD(P)H-binding
EXW56_RS24260	COG0656	L-ascorbic acid biosynthetic process
EXW56_RS24265	COG2814	Major facilitator Superfamily
EXW56_RS24270	COG1733	regulation of RNA biosynthetic process
EXW56_RS24280	COG1252	NADH dehydrogenase
EXW56_RS24305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW56_RS24340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW56_RS24350	COG1733	regulation of RNA biosynthetic process
EXW56_RS24355	COG1522	sequence-specific DNA binding
EXW56_RS24360	COG0288	reversible hydration of carbon dioxide
EXW56_RS24365	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW56_RS24370	COG2233	PERMEase
EXW56_RS24410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW56_RS24415	COG0557	exoribonuclease II activity
EXW56_RS24420	COG1647	Serine aminopeptidase, S33
EXW56_RS24425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW56_RS24430	COG1346	cytolysis
EXW56_RS24455	COG0149	triose-phosphate isomerase activity
EXW56_RS24460	COG0126	phosphoglycerate kinase activity
EXW56_RS24465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW56_RS24480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW56_RS24505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW56_RS24520	COG2323	membrane
EXW56_RS24530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW56_RS24535	COG1481	regulation of sporulation
EXW56_RS24540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW56_RS24545	COG1660	Displays ATPase and GTPase activities
EXW56_RS24550	COG1051	belongs to the nudix hydrolase family
EXW56_RS24560	COG0492	ferredoxin-NADP+ reductase activity
EXW56_RS24565	COG0457	Tetratricopeptide repeat
EXW56_RS24570	COG0110	maltose O-acetyltransferase activity
EXW56_RS24575	COG0546	phosphoglycolate phosphatase activity
EXW56_RS24580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW56_RS24585	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW56_RS24590	COG1950	PFAM Membrane protein of
EXW56_RS24595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW56_RS24615	COG0789	Transcriptional regulator
EXW56_RS24645	COG0583	DNA-binding transcription factor activity
EXW56_RS24650	COG0789	Transcriptional regulator
EXW56_RS24655	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW56_RS24660	COG0488	(ABC) transporter
EXW56_RS24670	COG1132	(ABC) transporter
EXW56_RS24675	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW56_RS24680	COG0583	DNA-binding transcription factor activity
EXW56_RS24685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW56_RS24690	COG0793	Belongs to the peptidase S41A family
EXW56_RS24690	COG3409	Peptidoglycan-binding domain 1 protein
EXW56_RS24695	COG2177	Part of the ABC transporter FtsEX involved in
EXW56_RS24700	COG2884	Cell division ATP-binding protein ftsE
EXW56_RS24735	COG1278	Cold shock
EXW56_RS24740	COG1040	competence protein
EXW56_RS24745	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW56_RS24750	COG0791	NLP P60 protein
EXW56_RS24750	COG1388	LysM domain
EXW56_RS24755	COG1733	regulation of RNA biosynthetic process
EXW56_RS24760	COG1307	EDD domain protein, DegV family
EXW56_RS24765	COG1739	Uncharacterized protein family UPF0029
EXW56_RS24770	COG1316	TRANSCRIPTIONal
EXW56_RS24775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW56_RS24780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW56_RS24785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW56_RS24795	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW56_RS24795	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW56_RS24815	COG1486	melibiose metabolic process
EXW56_RS24820	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW56_RS24825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS24835	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW56_RS24845	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW56_RS24855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW56_RS24860	COG1301	dicarboxylic acid transport
EXW56_RS24875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW56_RS24885	COG1271	oxidase subunit
EXW56_RS24890	COG1294	oxidase, subunit
EXW56_RS24895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW56_RS24900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW56_RS24905	COG1620	l-lactate permease
EXW56_RS24915	COG2389	metal-binding protein
EXW56_RS24925	COG1368	sulfuric ester hydrolase activity
EXW56_RS24935	COG0791	NLP P60 protein
EXW56_RS24935	COG1388	LysM domain
EXW56_RS24940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW56_RS24950	COG1215	transferase activity, transferring glycosyl groups
EXW56_RS24955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW56_RS24960	COG3584	3D domain protein
EXW56_RS24960	COG1388	LysM domain
EXW56_RS24975	COG4715	Zinc finger, swim domain protein
EXW56_RS24980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW56_RS25025	COG0577	efflux transmembrane transporter activity
EXW56_RS25030	COG1136	(ABC) transporter
EXW56_RS25055	COG5002	protein histidine kinase activity
EXW56_RS25055	COG3850	Histidine kinase
EXW56_RS25060	COG0745	RESPONSE REGULATOR receiver
EXW56_RS25065	COG1482	cell wall glycoprotein biosynthetic process
EXW56_RS25070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW56_RS25070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW56_RS25070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW56_RS25075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW56_RS25075	COG3711	transcriptional antiterminator
EXW56_RS25080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW56_RS25090	COG1316	TRANSCRIPTIONal
EXW56_RS25095	COG1482	cell wall glycoprotein biosynthetic process
EXW56_RS25100	COG0662	Cupin 2, conserved barrel domain protein
EXW56_RS25100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EXW56_RS25120	COG0438	transferase activity, transferring glycosyl groups
EXW56_RS25125	COG1215	transferase activity, transferring glycosyl groups
EXW56_RS25130	COG2244	polysaccharide biosynthetic process
EXW56_RS25155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW56_RS25160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW56_RS25165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW56_RS25170	COG4464	protein tyrosine phosphatase activity
EXW56_RS25175	COG0489	protein tyrosine kinase activity
EXW56_RS25180	COG3944	biosynthesis protein
EXW56_RS25185	COG0489	protein tyrosine kinase activity
EXW56_RS25200	COG1609	Transcriptional regulator
EXW56_RS25210	COG0739	heme binding
EXW56_RS25225	COG3279	Response regulator of the LytR AlgR family
EXW56_RS25230	COG2385	sporulation resulting in formation of a cellular spore
EXW56_RS25245	COG4836	Membrane
EXW56_RS25250	COG1007	ATP synthesis coupled electron transport
EXW56_RS25255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW56_RS25260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW56_RS25265	COG0713	ATP synthesis coupled electron transport
EXW56_RS25270	COG0839	Belongs to the complex I subunit 6 family
EXW56_RS25280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW56_RS25285	COG0649	NAD binding
EXW56_RS25290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW56_RS25295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW56_RS25300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW56_RS25305	COG3300	MHYT domain
EXW56_RS25305	COG5001	Diguanylate cyclase
EXW56_RS25320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW56_RS25325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW56_RS25335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW56_RS25345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW56_RS25355	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW56_RS25380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW56_RS25390	COG0698	ribose 5-phosphate isomerase
EXW56_RS25400	COG2190	(PTS) system
EXW56_RS25405	COG2259	Doxx family
EXW56_RS25410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW56_RS25420	COG1971	Probably functions as a manganese efflux pump
EXW56_RS25425	COG0009	L-threonylcarbamoyladenylate synthase
EXW56_RS25450	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW56_RS25455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW56_RS25460	COG1435	thymidine kinase activity
EXW56_RS25470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW56_RS25475	COG1494	fructose-1,6-bisphosphatase
EXW56_RS25495	COG4821	SIS domain
EXW56_RS25500	COG0504	CTP synthase activity
EXW56_RS25515	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS25520	COG1960	acyl-CoA dehydrogenase activity
EXW56_RS25525	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW56_RS25530	COG0183	Belongs to the thiolase family
EXW56_RS25535	COG0247	lactate metabolic process
EXW56_RS25535	COG2181	nitrate reductase activity
EXW56_RS25540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW56_RS25545	COG4294	response to UV
EXW56_RS25550	COG5001	Diguanylate cyclase
EXW56_RS25550	COG3300	MHYT domain
EXW56_RS25570	COG2197	response regulator
EXW56_RS25575	COG4585	Histidine kinase
EXW56_RS25580	COG0842	Transport permease protein
EXW56_RS25585	COG1131	(ABC) transporter
EXW56_RS25590	COG0024	Methionine aminopeptidase
EXW56_RS25595	COG2234	aminopeptidase activity
EXW56_RS25610	COG4506	Protein conserved in bacteria
EXW56_RS25615	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW56_RS25630	COG0010	Belongs to the arginase family
EXW56_RS25640	COG2814	Major facilitator Superfamily
EXW56_RS25645	COG0789	Transcriptional regulator
EXW56_RS25650	COG0584	glycerophosphoryl diester phosphodiesterase
EXW56_RS25655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW56_RS25665	COG1994	Peptidase M50
EXW56_RS25675	COG1078	dGTPase activity
EXW56_RS25680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW56_RS25685	COG1120	ATPase activity
EXW56_RS25690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS25695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW56_RS25700	COG4844	belongs to the
EXW56_RS25715	COG0280	phosphate acetyltransferase
EXW56_RS25720	COG3253	May function as heme-dependent peroxidase
EXW56_RS25730	COG3773	Cell wall hydrolase
EXW56_RS25740	COG2363	Small membrane protein
EXW56_RS25750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW56_RS25755	COG2233	PERMEase
EXW56_RS25760	COG0561	phosphatase activity
EXW56_RS25765	COG2814	Major facilitator Superfamily
EXW56_RS25770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW56_RS25775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW56_RS25780	COG1131	(ABC) transporter
EXW56_RS25785	COG2755	lipolytic protein G-D-S-L family
EXW56_RS25790	COG1609	Transcriptional regulator
EXW56_RS25800	COG0460	homoserine dehydrogenase
EXW56_RS25805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW56_RS25810	COG2873	o-acetylhomoserine
EXW56_RS25820	COG1011	Hydrolase
EXW56_RS25825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW56_RS25835	COG2197	response regulator
EXW56_RS25840	COG2203	Gaf domain
EXW56_RS25840	COG4585	Histidine kinase
EXW56_RS25845	COG0351	phosphomethylpyrimidine kinase
EXW56_RS25850	COG3706	GGDEF domain
EXW56_RS25855	COG2879	small protein
EXW56_RS25860	COG1966	Carbon starvation protein
EXW56_RS25865	COG3279	Response regulator of the LytR AlgR family
EXW56_RS25870	COG0477	Major facilitator Superfamily
EXW56_RS25895	COG0840	transmembrane signaling receptor activity
EXW56_RS25905	COG1607	acyl-coa hydrolase
EXW56_RS25910	COG1216	Glycosyl transferase, family 2
EXW56_RS25920	COG1216	Glycosyl transferase, family 2
EXW56_RS25935	COG1309	transcriptional regulator
EXW56_RS25940	COG0488	(ABC) transporter
EXW56_RS25945	COG1309	transcriptional regulator
EXW56_RS25950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW56_RS25955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW56_RS25955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW56_RS25960	COG0628	permease
EXW56_RS25970	COG1380	Effector of murein hydrolase LrgA
EXW56_RS25975	COG3279	Response regulator of the LytR AlgR family
EXW56_RS25980	COG3275	phosphorelay sensor kinase activity
EXW56_RS25985	COG2814	Major facilitator Superfamily
EXW56_RS25990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW56_RS25995	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW56_RS26040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW56_RS26045	COG1272	protein, Hemolysin III
EXW56_RS26070	COG1164	Oligoendopeptidase f
EXW56_RS26085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW56_RS26095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW56_RS26100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW56_RS26105	COG4853	Protein conserved in bacteria
EXW56_RS26115	COG5002	protein histidine kinase activity
EXW56_RS26120	COG0745	RESPONSE REGULATOR receiver
EXW56_RS26150	COG0305	Participates in initiation and elongation during chromosome replication
EXW56_RS26160	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW56_RS26165	COG4241	membrane
EXW56_RS26175	COG0629	single-stranded DNA binding
EXW56_RS26185	COG0012	GTP binding
EXW56_RS26190	COG4481	Protein conserved in bacteria
EXW56_RS26195	COG0668	transmembrane transport
EXW56_RS26205	COG1475	DNA binding
EXW56_RS26210	COG1192	Involved in chromosome partitioning
EXW56_RS26215	COG1475	DNA binding
EXW56_RS26225	COG0445	tRNA wobble uridine modification
EXW56_RS26230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW56_RS26235	COG1847	R3H domain protein
EXW56_RS26240	COG0706	membrane insertase activity
EXW56_RS26245	COG0594	ribonuclease P activity
EXW56_RS26250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW56_RS26280	COG0577	efflux transmembrane transporter activity
EXW56_RS26280	COG1136	(ABC) transporter
EXW56_RS26290	COG0582	viral genome integration into host DNA
EXW56_RS26300	COG1484	DNA-dependent DNA replication
EXW56_RS26480	COG0322	excinuclease ABC activity
EXW56_RS26490	COG5484	DNA packaging
EXW56_RS26580	COG4824	toxin secretion phage lysis holin
EXW56_RS26640	COG1396	sequence-specific DNA binding
EXW56_RS26820	COG2732	(Barnase) inhibitor
EXW56_RS26890	COG5002	protein histidine kinase activity
EXW56_RS26905	COG1279	arginine transmembrane transporter activity
EXW56_RS26910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW56_RS26930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW56_RS26950	COG0531	amino acid
EXW56_RS26955	COG3338	carbonate dehydratase activity
EXW56_RS26970	COG5002	protein histidine kinase activity
EXW56_RS26985	COG5002	protein histidine kinase activity
EXW56_RS27045	COG4565	transcriptional regulatory protein
EXW56_RS27050	COG3290	protein histidine kinase activity
EXW56_RS27055	COG3227	Zinc metalloprotease (Elastase)
EXW56_RS27110	COG1595	DNA-templated transcription, initiation
EXW56_RS27130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EXW56_RS27185	COG1476	TRANSCRIPTIONal
EXW56_RS27240	COG0745	RESPONSE REGULATOR receiver
EXW56_RS27245	COG5002	protein histidine kinase activity
EXW56_RS27295	COG0697	spore germination
EXW56_RS27300	COG0814	amino acid
EXW56_RS27330	COG1329	Transcriptional regulator
EXW56_RS27380	COG0494	nUDIX hydrolase
EXW56_RS27465	COG1192	Involved in chromosome partitioning
EXW56_RS27750	COG1671	Belongs to the UPF0178 family