locus-tag	class	description
I5818_RS00010	COG0592	DNA-directed DNA polymerase activity
I5818_RS00015	COG2501	S4 domain
I5818_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_RS00030	COG0187	DNA topoisomerase II activity
I5818_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5818_RS00075	COG0516	GMP reductase activity
I5818_RS00075	COG0517	IMP dehydrogenase activity
I5818_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I5818_RS00100	COG1428	Deoxynucleoside kinase
I5818_RS00105	COG1428	Deoxynucleoside kinase
I5818_RS00110	COG3858	chitin binding
I5818_RS00110	COG1388	LysM domain
I5818_RS00115	COG0590	tRNA wobble adenosine to inosine editing
I5818_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5818_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5818_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5818_RS00180	COG1982	Orn Lys Arg decarboxylase major
I5818_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5818_RS00190	COG3870	Protein conserved in bacteria
I5818_RS00195	COG1728	Protein conserved in bacteria
I5818_RS00200	COG0470	DNA polymerase III
I5818_RS00205	COG1774	PSP1 C-terminal conserved region
I5818_RS00210	COG4467	Involved in initiation control of chromosome replication
I5818_RS00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5818_RS00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5818_RS00225	COG2002	toxin-antitoxin pair type II binding
I5818_RS00235	COG0084	hydrolase, TatD family'
I5818_RS00240	COG3583	domain protein
I5818_RS00240	COG3584	3D domain protein
I5818_RS00260	COG4466	Protein conserved in bacteria
I5818_RS00270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I5818_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5818_RS00280	COG0251	oxidation-reduction process
I5818_RS00285	COG2088	sporulation resulting in formation of a cellular spore
I5818_RS00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5818_RS00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5818_RS00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5818_RS00320	COG2002	toxin-antitoxin pair type II binding
I5818_RS00325	COG2244	polysaccharide biosynthetic process
I5818_RS00330	COG3956	TIGRFAM MazG family protein
I5818_RS00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5818_RS00355	COG1098	S1 RNA binding domain
I5818_RS00370	COG2208	phosphoserine phosphatase activity
I5818_RS00375	COG2304	oxidoreductase activity
I5818_RS00380	COG0515	serine threonine protein kinase
I5818_RS00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5818_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5818_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5818_RS00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5818_RS00410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5818_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5818_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5818_RS00430	COG1396	sequence-specific DNA binding
I5818_RS00520	COG3880	PFAM UvrB UvrC protein
I5818_RS00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I5818_RS00530	COG0542	response to heat
I5818_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5818_RS00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I5818_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
I5818_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5818_RS00555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5818_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5818_RS00565	COG1045	serine acetyltransferase
I5818_RS00570	COG0215	cysteine-tRNA ligase activity
I5818_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5818_RS00585	COG3688	RNA-binding protein containing a PIN domain
I5818_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5818_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
I5818_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5818_RS00615	COG0081	regulation of translation
I5818_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5818_RS00625	COG0222	ribosome binding
I5818_RS00630	COG2813	Specifically methylates the guanine in position
I5818_RS00635	COG0085	RNA polymerase activity
I5818_RS00645	COG1358	cellular component organization or biogenesis
I5818_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5818_RS00655	COG0049	tRNA binding
I5818_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5818_RS00670	COG0051	transcription antitermination factor activity, RNA binding
I5818_RS00680	COG0088	Forms part of the polypeptide exit tunnel
I5818_RS00685	COG0089	rRNA binding
I5818_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5818_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5818_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5818_RS00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5818_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5818_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
I5818_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5818_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5818_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5818_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5818_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5818_RS00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5818_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5818_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5818_RS00765	COG1841	ribosomal large subunit assembly
I5818_RS00775	COG0201	protein transport
I5818_RS00780	COG0563	adenylate kinase activity
I5818_RS00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5818_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5818_RS00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5818_RS00810	COG0202	RNA polymerase activity
I5818_RS00815	COG0203	ribosomal protein L17
I5818_RS00820	COG1122	ATPase activity
I5818_RS00825	COG1122	ATPase activity
I5818_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5818_RS00835	COG0101	tRNA pseudouridine synthase activity
I5818_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5818_RS00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5818_RS00880	COG3403	YqcI/YcgG family
I5818_RS00895	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS00900	COG0489	protein tyrosine kinase activity
I5818_RS00910	COG2194	sulfuric ester hydrolase activity
I5818_RS00915	COG0726	polysaccharide deacetylase
I5818_RS00985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_RS00995	COG1595	DNA-templated transcription, initiation
I5818_RS01000	COG5662	AntiSigma factor
I5818_RS01005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I5818_RS01010	COG4856	YbbR-like protein
I5818_RS01015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5818_RS01020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_RS01040	COG0784	Response regulator, receiver
I5818_RS01040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS01040	COG2198	Histidine kinase
I5818_RS01040	COG2205	protein histidine kinase activity
I5818_RS01070	COG5504	Zn-dependent protease
I5818_RS01105	COG0798	PFAM Bile acid sodium symporter
I5818_RS01110	COG0640	Transcriptional regulator
I5818_RS01115	COG1388	LysM domain
I5818_RS01125	COG2814	Major facilitator Superfamily
I5818_RS01130	COG2226	methyltransferase
I5818_RS01135	COG0488	(ABC) transporter
I5818_RS01145	COG0789	Transcriptional regulator
I5818_RS01145	COG4978	Transcriptional regulator
I5818_RS01150	COG1349	DNA-binding transcription factor activity
I5818_RS01155	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_RS01160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS01160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS01160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS01165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS01180	COG0017	Asparaginyl-tRNA synthetase
I5818_RS01195	COG0662	Cupin 2, conserved barrel domain protein
I5818_RS01220	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_RS01230	COG0640	Transcriptional regulator
I5818_RS01245	COG1114	Component of the transport system for branched-chain amino acids
I5818_RS01255	COG1802	Transcriptional regulator
I5818_RS01270	COG4122	O-methyltransferase activity
I5818_RS01285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS01295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS01300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS01310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_RS01315	COG3832	glyoxalase III activity
I5818_RS01330	COG3226	Transcriptional regulator
I5818_RS01365	COG2076	Multidrug Resistance protein
I5818_RS01375	COG0519	Catalyzes the synthesis of GMP from XMP
I5818_RS01385	COG0406	alpha-ribazole phosphatase activity
I5818_RS01400	COG0477	Major facilitator Superfamily
I5818_RS01405	COG2226	methyltransferase
I5818_RS01415	COG1937	Protein conserved in bacteria
I5818_RS01425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS01425	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_RS01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS01430	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_RS01435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5818_RS01440	COG2210	Belongs to the sulfur carrier protein TusA family
I5818_RS01445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS01445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS01450	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_RS01455	COG0730	response to heat
I5818_RS01460	COG2207	Transcriptional regulator
I5818_RS01460	COG3708	Transcriptional regulator
I5818_RS01500	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_RS01520	COG1695	Transcriptional regulator
I5818_RS01530	COG0586	Pfam SNARE associated Golgi protein
I5818_RS01535	COG2807	transmembrane transport
I5818_RS01540	COG2186	Transcriptional regulator
I5818_RS01545	COG0745	RESPONSE REGULATOR receiver
I5818_RS01550	COG2205	protein histidine kinase activity
I5818_RS01555	COG1136	(ABC) transporter
I5818_RS01560	COG0577	efflux transmembrane transporter activity
I5818_RS01565	COG0840	transmembrane signaling receptor activity
I5818_RS01575	COG1131	(ABC) transporter
I5818_RS01580	COG2205	protein histidine kinase activity
I5818_RS01585	COG0745	RESPONSE REGULATOR receiver
I5818_RS01600	COG0789	Transcriptional regulator
I5818_RS01605	COG0745	RESPONSE REGULATOR receiver
I5818_RS01610	COG2205	protein histidine kinase activity
I5818_RS01615	COG1136	(ABC) transporter
I5818_RS01620	COG0577	efflux transmembrane transporter activity
I5818_RS01635	COG0783	Belongs to the Dps family
I5818_RS01640	COG0824	Thioesterase
I5818_RS01650	COG1609	Transcriptional regulator
I5818_RS01660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5818_RS01675	COG0765	amino acid transport
I5818_RS01680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS01705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5818_RS01710	COG2378	regulation of single-species biofilm formation
I5818_RS01715	COG3708	Transcriptional regulator
I5818_RS01720	COG0702	epimerase
I5818_RS01730	COG2197	response regulator
I5818_RS01735	COG4585	Histidine kinase
I5818_RS01740	COG0842	Transport permease protein
I5818_RS01745	COG1131	(ABC) transporter
I5818_RS01770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_RS01780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5818_RS01790	COG0423	glycine-tRNA ligase activity
I5818_RS01805	COG0833	amino acid
I5818_RS01810	COG0531	amino acid
I5818_RS01815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_RS01820	COG0628	permease
I5818_RS01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS01835	COG0765	amino acid transport
I5818_RS01840	COG0765	amino acid transport
I5818_RS01850	COG3279	Response regulator of the LytR AlgR family
I5818_RS01855	COG4555	ABC transporter
I5818_RS01860	COG1668	transmembrane transport
I5818_RS01870	COG1090	epimerase
I5818_RS01875	COG0628	permease
I5818_RS01880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_RS01890	COG0791	NLP P60 protein
I5818_RS01890	COG1388	LysM domain
I5818_RS01895	COG1733	regulation of RNA biosynthetic process
I5818_RS01910	COG1131	(ABC) transporter
I5818_RS01930	COG1051	belongs to the nudix hydrolase family
I5818_RS01935	COG1346	cytolysis
I5818_RS01945	COG0583	DNA-binding transcription factor activity
I5818_RS01950	COG3339	Conserved Protein
I5818_RS01955	COG0586	Pfam SNARE associated Golgi protein
I5818_RS01970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_RS01985	COG1686	Belongs to the peptidase S11 family
I5818_RS01990	COG0069	glutamate synthase activity
I5818_RS01995	COG0697	spore germination
I5818_RS02005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_RS02010	COG0531	amino acid
I5818_RS02050	COG1376	ErfK ybiS ycfS ynhG family protein
I5818_RS02060	COG2011	ABC-type metal ion transport system permease component
I5818_RS02075	COG1114	Component of the transport system for branched-chain amino acids
I5818_RS02090	COG1132	(ABC) transporter
I5818_RS02100	COG5002	protein histidine kinase activity
I5818_RS02105	COG1131	(ABC) transporter
I5818_RS02135	COG0583	DNA-binding transcription factor activity
I5818_RS02140	COG0372	Belongs to the citrate synthase family
I5818_RS02145	COG1876	peptidase activity
I5818_RS02150	COG0640	Transcriptional regulator
I5818_RS02175	COG0726	polysaccharide deacetylase
I5818_RS02180	COG0004	ammonium transporteR
I5818_RS02185	COG0626	cystathionine gamma-synthase activity
I5818_RS02190	COG0626	cystathionine gamma-synthase activity
I5818_RS02195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5818_RS02195	COG0646	methionine synthase
I5818_RS02200	COG0646	methionine synthase
I5818_RS02200	COG1410	methionine synthase
I5818_RS02205	COG1695	Transcriptional regulator
I5818_RS02220	COG0791	NLP P60 protein
I5818_RS02220	COG3883	PFAM NLP P60 protein
I5818_RS02225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5818_RS02245	COG0183	Belongs to the thiolase family
I5818_RS02255	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS02275	COG0681	Belongs to the peptidase S26 family
I5818_RS02295	COG1404	Belongs to the peptidase S8 family
I5818_RS02305	COG1191	sigma factor activity
I5818_RS02330	COG1737	Transcriptional regulator
I5818_RS02345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5818_RS02350	COG3383	formate dehydrogenase (NAD+) activity
I5818_RS02355	COG2223	nitrite transmembrane transporter activity
I5818_RS02365	COG4086	secreted protein
I5818_RS02370	COG4166	transmembrane transport
I5818_RS02375	COG0601	transmembrane transport
I5818_RS02380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS02385	COG0444	Belongs to the ABC transporter superfamily
I5818_RS02390	COG4608	Belongs to the ABC transporter superfamily
I5818_RS02400	COG2135	peptidase activity
I5818_RS02425	COG1263	PTS System
I5818_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS02425	COG2190	(PTS) system
I5818_RS02445	COG5002	protein histidine kinase activity
I5818_RS02450	COG0745	RESPONSE REGULATOR receiver
I5818_RS02455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_RS02460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I5818_RS02465	COG1335	isochorismatase
I5818_RS02470	COG0531	amino acid
I5818_RS02490	COG1960	acyl-CoA dehydrogenase activity
I5818_RS02520	COG2996	Protein conserved in bacteria
I5818_RS02525	COG1164	Oligoendopeptidase f
I5818_RS02540	COG2972	Histidine kinase
I5818_RS02545	COG4753	response regulator
I5818_RS02545	COG4753	response regulator
I5818_RS02545	COG2207	Transcriptional regulator
I5818_RS02545	COG2207	Transcriptional regulator
I5818_RS02550	COG0753	catalase activity
I5818_RS02555	COG0735	belongs to the Fur family
I5818_RS02560	COG0840	transmembrane signaling receptor activity
I5818_RS02570	COG1175	transmembrane transport
I5818_RS02575	COG0395	ABC-type sugar transport system, permease component
I5818_RS02580	COG0626	cystathionine gamma-synthase activity
I5818_RS02585	COG0656	L-ascorbic acid biosynthetic process
I5818_RS02590	COG2814	Major facilitator Superfamily
I5818_RS02595	COG1733	regulation of RNA biosynthetic process
I5818_RS02600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_RS02615	COG0477	Major facilitator Superfamily
I5818_RS02620	COG1404	Belongs to the peptidase S8 family
I5818_RS02620	COG4412	M6 family metalloprotease domain protein
I5818_RS02625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5818_RS02635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5818_RS02645	COG2226	methyltransferase
I5818_RS02655	COG2076	Multidrug Resistance protein
I5818_RS02660	COG2076	Multidrug Resistance protein
I5818_RS02665	COG1309	transcriptional regulator
I5818_RS02675	COG0583	DNA-binding transcription factor activity
I5818_RS02700	COG1694	Mazg nucleotide pyrophosphohydrolase
I5818_RS02710	COG2226	methyltransferase
I5818_RS02730	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_RS02745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5818_RS02765	COG2816	NAD+ diphosphatase activity
I5818_RS02770	COG0357	Ribosomal RNA small subunit methyltransferase G
I5818_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS02790	COG0592	DNA-directed DNA polymerase activity
I5818_RS02805	COG2610	gluconate transmembrane transporter activity
I5818_RS02810	COG1929	Belongs to the glycerate kinase type-1 family
I5818_RS02815	COG3835	regulator
I5818_RS02820	COG0346	lactoylglutathione lyase activity
I5818_RS02830	COG1690	Belongs to the RtcB family
I5818_RS02845	COG0326	Molecular chaperone. Has ATPase activity
I5818_RS02865	COG1533	DNA photolyase activity
I5818_RS02890	COG4294	response to UV
I5818_RS03055	COG2318	DinB family
I5818_RS03065	COG0693	protein deglycase activity
I5818_RS03080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS03085	COG2207	Transcriptional regulator
I5818_RS03085	COG3708	Transcriptional regulator
I5818_RS03095	COG1846	Transcriptional regulator
I5818_RS03105	COG0577	efflux transmembrane transporter activity
I5818_RS03110	COG1136	(ABC) transporter
I5818_RS03115	COG2207	Transcriptional regulator
I5818_RS03145	COG1741	Belongs to the pirin family
I5818_RS03150	COG2318	DinB family
I5818_RS03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_RS03170	COG1289	transmembrane transporter activity
I5818_RS03175	COG0494	nUDIX hydrolase
I5818_RS03180	COG2514	catechol 2,3-dioxygenase activity
I5818_RS03190	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I5818_RS03235	COG2078	PFAM AMMECR1 domain protein
I5818_RS03235	COG3885	ferrous iron binding
I5818_RS03250	COG1115	amino acid carrier protein
I5818_RS03255	COG1063	alcohol dehydrogenase
I5818_RS03265	COG2318	DinB family
I5818_RS03280	COG1316	TRANSCRIPTIONal
I5818_RS03290	COG0363	glucosamine-6-phosphate deaminase activity
I5818_RS03295	COG2188	Transcriptional regulator
I5818_RS03320	COG0791	NLP P60 protein
I5818_RS03320	COG1388	LysM domain
I5818_RS03325	COG0768	penicillin binding
I5818_RS03355	COG1309	transcriptional regulator
I5818_RS03370	COG2153	protein acetylation
I5818_RS03375	COG0445	tRNA wobble uridine modification
I5818_RS03380	COG1368	sulfuric ester hydrolase activity
I5818_RS03385	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS03390	COG1404	Belongs to the peptidase S8 family
I5818_RS03400	COG1361	Conserved repeat domain
I5818_RS03400	COG2911	Protein conserved in bacteria
I5818_RS03400	COG3266	domain, Protein
I5818_RS03465	COG4974	Belongs to the 'phage' integrase family
I5818_RS03490	COG0463	Glycosyl transferase, family 2
I5818_RS03495	COG0463	Glycosyl transferase, family 2
I5818_RS03495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_RS03510	COG1063	alcohol dehydrogenase
I5818_RS03515	COG1082	Xylose isomerase domain protein TIM barrel
I5818_RS03520	COG1609	Transcriptional regulator
I5818_RS03525	COG1879	ABC-type sugar transport system periplasmic component
I5818_RS03530	COG1129	ABC transporter
I5818_RS03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5818_RS03540	COG0673	inositol 2-dehydrogenase activity
I5818_RS03575	COG2188	Transcriptional regulator
I5818_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_RS03585	COG1840	ABC-type Fe3 transport system, periplasmic component
I5818_RS03590	COG3842	ATPase activity
I5818_RS03595	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5818_RS03600	COG1177	transmembrane transport
I5818_RS03615	COG0601	transmembrane transport
I5818_RS03620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS03625	COG0444	Belongs to the ABC transporter superfamily
I5818_RS03630	COG4608	Belongs to the ABC transporter superfamily
I5818_RS03635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_RS03660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5818_RS03685	COG1595	DNA-templated transcription, initiation
I5818_RS03690	COG2972	Histidine kinase
I5818_RS03695	COG3279	Response regulator of the LytR AlgR family
I5818_RS03715	COG0395	ABC-type sugar transport system, permease component
I5818_RS03720	COG0445	tRNA wobble uridine modification
I5818_RS03725	COG1405	negative regulation of cell septum assembly
I5818_RS03725	COG3012	SEC-C Motif Domain Protein
I5818_RS03735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_RS03745	COG2207	Transcriptional regulator
I5818_RS03755	COG0756	dUTP diphosphatase activity
I5818_RS03765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_RS03770	COG1780	Probably involved in ribonucleotide reductase function
I5818_RS03785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS03785	COG2213	PTS system mannitol-specific
I5818_RS03795	COG3775	system Galactitol-specific IIC component
I5818_RS03800	COG1063	alcohol dehydrogenase
I5818_RS03810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5818_RS03815	COG0561	phosphatase activity
I5818_RS03820	COG3684	Belongs to the aldolase LacD family
I5818_RS03825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS03825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS03825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS03830	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_RS03835	COG1737	Transcriptional regulator
I5818_RS03845	COG0800	Aldolase
I5818_RS03850	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I5818_RS03865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS03870	COG2188	Transcriptional regulator
I5818_RS03880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5818_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS03890	COG1309	transcriptional regulator
I5818_RS03895	COG2814	Major facilitator Superfamily
I5818_RS03905	COG4405	Protein conserved in bacteria
I5818_RS03915	COG1522	sequence-specific DNA binding
I5818_RS03930	COG0745	RESPONSE REGULATOR receiver
I5818_RS03935	COG2205	protein histidine kinase activity
I5818_RS03940	COG1136	(ABC) transporter
I5818_RS03945	COG0577	efflux transmembrane transporter activity
I5818_RS03960	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_RS03965	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_RS03980	COG1175	transmembrane transport
I5818_RS03985	COG3842	ATPase activity
I5818_RS03995	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5818_RS04010	COG5298	Protein conserved in bacteria
I5818_RS04015	COG1215	transferase activity, transferring glycosyl groups
I5818_RS04025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5818_RS04030	COG1011	Hydrolase
I5818_RS04035	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I5818_RS04050	COG0028	Belongs to the TPP enzyme family
I5818_RS04065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS04095	COG2304	oxidoreductase activity
I5818_RS04105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5818_RS04110	COG1984	allophanate hydrolase subunit 2
I5818_RS04115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5818_RS04140	COG1396	sequence-specific DNA binding
I5818_RS04180	COG0601	transmembrane transport
I5818_RS04190	COG0444	Belongs to the ABC transporter superfamily
I5818_RS04195	COG4608	Belongs to the ABC transporter superfamily
I5818_RS04200	COG2204	response regulator
I5818_RS04205	COG2362	D-Aminopeptidase
I5818_RS04215	COG0697	spore germination
I5818_RS04220	COG1522	sequence-specific DNA binding
I5818_RS04355	COG2222	sugar isomerase
I5818_RS04360	COG1653	transport
I5818_RS04365	COG1175	transmembrane transport
I5818_RS04370	COG0395	ABC-type sugar transport system, permease component
I5818_RS04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5818_RS04380	COG2188	Transcriptional regulator
I5818_RS04385	COG2234	aminopeptidase activity
I5818_RS04390	COG1063	alcohol dehydrogenase
I5818_RS04395	COG1309	transcriptional regulator
I5818_RS04400	COG1473	amidohydrolase
I5818_RS04405	COG1473	amidohydrolase
I5818_RS04410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_RS04420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5818_RS04425	COG4149	molybdate abc transporter
I5818_RS04430	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5818_RS04435	COG1910	domain protein
I5818_RS04440	COG5564	TIM-barrel signal transduction protein
I5818_RS04450	COG5564	TIM-barrel signal transduction protein
I5818_RS04460	COG2084	Dehydrogenase
I5818_RS04470	COG2610	gluconate transmembrane transporter activity
I5818_RS04480	COG2271	Major facilitator Superfamily
I5818_RS04485	COG1473	amidohydrolase
I5818_RS04490	COG2205	protein histidine kinase activity
I5818_RS04495	COG1914	H( )-stimulated, divalent metal cation uptake system
I5818_RS04500	COG1073	alpha beta
I5818_RS04505	COG1620	l-lactate permease
I5818_RS04510	COG2186	Transcriptional regulator
I5818_RS04515	COG0247	lactate metabolic process
I5818_RS04520	COG1139	Iron-sulfur cluster binding protein
I5818_RS04525	COG1556	Lactate utilization protein
I5818_RS04530	COG0601	transmembrane transport
I5818_RS04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS04540	COG0444	Belongs to the ABC transporter superfamily
I5818_RS04545	COG4608	Belongs to the ABC transporter superfamily
I5818_RS04550	COG4166	transmembrane transport
I5818_RS04555	COG2362	D-Aminopeptidase
I5818_RS04560	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_RS04565	COG0531	amino acid
I5818_RS04585	COG3275	phosphorelay sensor kinase activity
I5818_RS04590	COG0840	transmembrane signaling receptor activity
I5818_RS04600	COG2081	HI0933 family
I5818_RS04615	COG1175	transmembrane transport
I5818_RS04620	COG0395	ABC-type sugar transport system, permease component
I5818_RS04630	COG2188	Transcriptional regulator
I5818_RS04645	COG1473	amidohydrolase
I5818_RS04650	COG1288	antiporter activity
I5818_RS04665	COG1388	LysM domain
I5818_RS04665	COG0791	NLP P60 protein
I5818_RS04675	COG1263	PTS System
I5818_RS04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS04680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_RS04690	COG2130	NADP-dependent
I5818_RS04700	COG3711	transcriptional antiterminator
I5818_RS04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS04720	COG4821	SIS domain
I5818_RS04725	COG1414	Transcriptional regulator
I5818_RS04740	COG2814	Major facilitator Superfamily
I5818_RS04755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_RS04760	COG2368	4-hydroxyphenylacetate
I5818_RS04770	COG2814	Major facilitator Superfamily
I5818_RS04780	COG0251	oxidation-reduction process
I5818_RS04810	COG0583	DNA-binding transcription factor activity
I5818_RS04815	COG3180	Ammonia monooxygenase
I5818_RS04820	COG3290	protein histidine kinase activity
I5818_RS04825	COG4565	transcriptional regulatory protein
I5818_RS04845	COG2079	MmgE PrpD family protein
I5818_RS04850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5818_RS04855	COG0786	glutamate:sodium symporter activity
I5818_RS04860	COG0010	Belongs to the arginase family
I5818_RS04865	COG0583	DNA-binding transcription factor activity
I5818_RS04875	COG1263	PTS System
I5818_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS04875	COG2190	(PTS) system
I5818_RS04885	COG2190	(PTS) system
I5818_RS04905	COG1473	amidohydrolase
I5818_RS04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5818_RS04915	COG0861	Integral membrane protein TerC family
I5818_RS04920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_RS04925	COG1472	Belongs to the glycosyl hydrolase 3 family
I5818_RS04930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_RS04940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5818_RS04945	COG1234	tRNA 3'-trailer cleavage
I5818_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS04980	COG1131	(ABC) transporter
I5818_RS05015	COG0561	phosphatase activity
I5818_RS05020	COG0647	UMP catabolic process
I5818_RS05025	COG1285	pathogenesis
I5818_RS05030	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_RS05050	COG1175	transmembrane transport
I5818_RS05055	COG0395	ABC-type sugar transport system, permease component
I5818_RS05060	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I5818_RS05070	COG1737	Transcriptional regulator
I5818_RS05075	COG1082	Xylose isomerase domain protein TIM barrel
I5818_RS05090	COG1053	succinate dehydrogenase
I5818_RS05090	COG3976	FMN-binding domain protein
I5818_RS05100	COG0673	inositol 2-dehydrogenase activity
I5818_RS05105	COG0673	inositol 2-dehydrogenase activity
I5818_RS05110	COG0561	phosphatase activity
I5818_RS05120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I5818_RS05125	COG1263	PTS System
I5818_RS05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS05125	COG2190	(PTS) system
I5818_RS05130	COG2190	(PTS) system
I5818_RS05140	COG3180	Ammonia monooxygenase
I5818_RS05145	COG2188	Transcriptional regulator
I5818_RS05155	COG2222	sugar isomerase
I5818_RS05160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS05165	COG3715	PTS system
I5818_RS05170	COG3716	PTS system mannose fructose sorbose family IID component
I5818_RS05175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5818_RS05180	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_RS05185	COG3684	Belongs to the aldolase LacD family
I5818_RS05195	COG1940	carbohydrate kinase activity
I5818_RS05205	COG1840	ABC-type Fe3 transport system, periplasmic component
I5818_RS05210	COG3842	ATPase activity
I5818_RS05220	COG0165	Argininosuccinate lyase
I5818_RS05225	COG0385	Bile acid
I5818_RS05240	COG2723	6-phospho-beta-galactosidase activity
I5818_RS05250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS05260	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_RS05265	COG1486	melibiose metabolic process
I5818_RS05270	COG0084	hydrolase, TatD family'
I5818_RS05280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5818_RS05290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5818_RS05295	COG1122	ATPase activity
I5818_RS05305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5818_RS05320	COG0737	Belongs to the 5'-nucleotidase family
I5818_RS05335	COG1368	sulfuric ester hydrolase activity
I5818_RS05345	COG4196	transglutaminase domain protein
I5818_RS05350	COG1361	Conserved repeat domain
I5818_RS05355	COG2909	trisaccharide binding
I5818_RS05365	COG0653	protein targeting
I5818_RS05370	COG4193	domain, Protein
I5818_RS05370	COG5263	repeat protein
I5818_RS05380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I5818_RS05385	COG2244	polysaccharide biosynthetic process
I5818_RS05400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_RS05405	COG0840	transmembrane signaling receptor activity
I5818_RS05420	COG2972	Histidine kinase
I5818_RS05425	COG4753	response regulator
I5818_RS05425	COG2207	Transcriptional regulator
I5818_RS05430	COG2182	Extracellular solute-binding protein
I5818_RS05435	COG1175	transmembrane transport
I5818_RS05440	COG0395	ABC-type sugar transport system, permease component
I5818_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS05455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_RS05460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_RS05465	COG3250	beta-galactosidase activity
I5818_RS05475	COG0523	cobalamin synthesis protein
I5818_RS05480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_RS05485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_RS05490	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_RS05495	COG0069	glutamate synthase activity
I5818_RS05500	COG1309	transcriptional regulator
I5818_RS05520	COG1846	Transcriptional regulator
I5818_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS05535	COG2205	protein histidine kinase activity
I5818_RS05540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_RS05560	COG1595	DNA-templated transcription, initiation
I5818_RS05565	COG1388	LysM domain
I5818_RS05565	COG3858	chitin binding
I5818_RS05575	COG0840	transmembrane signaling receptor activity
I5818_RS05580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_RS05585	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
I5818_RS05590	COG1595	DNA-templated transcription, initiation
I5818_RS05610	COG5566	PFAM Mor transcription activator
I5818_RS05620	COG0753	catalase activity
I5818_RS05630	COG2814	Major facilitator Superfamily
I5818_RS05645	COG0456	acetyltransferase
I5818_RS05650	COG0406	alpha-ribazole phosphatase activity
I5818_RS05660	COG2318	DinB family
I5818_RS05665	COG2323	membrane
I5818_RS05670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS05690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5818_RS05705	COG1131	(ABC) transporter
I5818_RS05715	COG2197	response regulator
I5818_RS05735	COG1316	TRANSCRIPTIONal
I5818_RS05740	COG1739	Uncharacterized protein family UPF0029
I5818_RS05745	COG4585	Histidine kinase
I5818_RS05750	COG2197	response regulator
I5818_RS05760	COG1263	PTS System
I5818_RS05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS05765	COG0366	Alpha amylase catalytic
I5818_RS05770	COG2188	Transcriptional regulator
I5818_RS05785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I5818_RS05790	COG1307	EDD domain protein, DegV family
I5818_RS05800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_RS05805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5818_RS05840	COG5582	Belongs to the UPF0302 family
I5818_RS06105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5818_RS06130	COG1256	bacterial-type flagellum assembly
I5818_RS06130	COG4786	Flagellar basal body rod
I5818_RS06135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_RS06145	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I5818_RS06150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5818_RS06155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_RS06175	COG2089	acid synthase
I5818_RS06180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5818_RS06185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5818_RS06190	COG1516	flagellar protein fliS
I5818_RS06220	COG1063	alcohol dehydrogenase
I5818_RS06225	COG4191	Histidine kinase
I5818_RS06240	COG0840	transmembrane signaling receptor activity
I5818_RS06245	COG1334	flagellar protein FlaG
I5818_RS06255	COG0840	transmembrane signaling receptor activity
I5818_RS06265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_RS06275	COG1522	sequence-specific DNA binding
I5818_RS06280	COG0405	Gamma-glutamyltransferase
I5818_RS06285	COG2059	Chromate
I5818_RS06290	COG2059	Chromate
I5818_RS06300	COG0653	protein targeting
I5818_RS06315	COG2884	Cell division ATP-binding protein ftsE
I5818_RS06320	COG2177	Part of the ABC transporter FtsEX involved in
I5818_RS06325	COG0791	NLP P60 protein
I5818_RS06325	COG3883	PFAM NLP P60 protein
I5818_RS06335	COG0626	cystathionine gamma-synthase activity
I5818_RS06340	COG2873	o-acetylhomoserine
I5818_RS06345	COG0460	homoserine dehydrogenase
I5818_RS06350	COG3409	Peptidoglycan-binding domain 1 protein
I5818_RS06350	COG0793	Belongs to the peptidase S41A family
I5818_RS06355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5818_RS06365	COG0569	domain protein
I5818_RS06380	COG0346	lactoylglutathione lyase activity
I5818_RS06385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_RS06395	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS06410	COG0431	NADPH-dependent FMN reductase
I5818_RS06420	COG0745	RESPONSE REGULATOR receiver
I5818_RS06425	COG5002	protein histidine kinase activity
I5818_RS06435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5818_RS06440	COG0573	inorganic phosphate transmembrane transporter activity
I5818_RS06445	COG0581	inorganic phosphate transmembrane transporter activity
I5818_RS06450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_RS06455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_RS06460	COG0704	Plays a role in the regulation of phosphate uptake
I5818_RS06465	COG0640	Transcriptional regulator
I5818_RS06475	COG1953	Uracil, thiamine, allantoin
I5818_RS06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_RS06485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_RS06490	COG2508	Transcriptional regulator
I5818_RS06500	COG2233	PERMEase
I5818_RS06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_RS06515	COG3257	ureidoglycine aminohydrolase activity
I5818_RS06520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5818_RS06525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5818_RS06530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_RS06535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_RS06540	COG0549	Belongs to the carbamate kinase family
I5818_RS06545	COG0251	oxidation-reduction process
I5818_RS06550	COG2814	Major facilitator Superfamily
I5818_RS06560	COG4897	Protein conserved in bacteria
I5818_RS06565	COG0556	nucleotide-excision repair
I5818_RS06570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5818_RS06575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5818_RS06580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_RS06585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_RS06590	COG1682	transport, permease protein
I5818_RS06595	COG1134	teichoic acid transport
I5818_RS06605	COG3595	metallopeptidase activity
I5818_RS06610	COG1950	PFAM Membrane protein of
I5818_RS06615	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS06630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I5818_RS06640	COG0110	maltose O-acetyltransferase activity
I5818_RS06645	COG0457	Tetratricopeptide repeat
I5818_RS06650	COG0492	ferredoxin-NADP+ reductase activity
I5818_RS06655	COG1051	belongs to the nudix hydrolase family
I5818_RS06660	COG1660	Displays ATPase and GTPase activities
I5818_RS06665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5818_RS06670	COG1481	regulation of sporulation
I5818_RS06675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS06680	COG0740	serine-type endopeptidase activity
I5818_RS06690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5818_RS06705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5818_RS06710	COG0126	phosphoglycerate kinase activity
I5818_RS06715	COG0149	triose-phosphate isomerase activity
I5818_RS06720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5818_RS06725	COG0148	phosphopyruvate hydratase activity
I5818_RS06730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5818_RS06735	COG1647	Serine aminopeptidase, S33
I5818_RS06740	COG0557	exoribonuclease II activity
I5818_RS06745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5818_RS06765	COG1053	succinate dehydrogenase
I5818_RS06780	COG2720	vancomycin resistance protein
I5818_RS06805	COG1609	Transcriptional regulator
I5818_RS06810	COG0366	Alpha amylase catalytic
I5818_RS06815	COG0366	Alpha amylase catalytic
I5818_RS06820	COG2318	DinB family
I5818_RS06825	COG2318	DinB family
I5818_RS06830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5818_RS06835	COG1937	Protein conserved in bacteria
I5818_RS06840	COG2608	mercury ion transmembrane transporter activity
I5818_RS06845	COG2217	Heavy metal translocating P-type atpase
I5818_RS06855	COG3973	AAA domain
I5818_RS06865	COG2239	Acts as a magnesium transporter
I5818_RS06870	COG1309	transcriptional regulator
I5818_RS06875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5818_RS06890	COG5577	PFAM Coat F domain
I5818_RS06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_RS06900	COG0772	Belongs to the SEDS family
I5818_RS06935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_RS06940	COG0805	protein transport
I5818_RS06945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS06955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS06960	COG1120	ATPase activity
I5818_RS06975	COG0247	lactate metabolic process
I5818_RS06980	COG0277	FAD linked oxidase domain protein
I5818_RS06985	COG3835	regulator
I5818_RS06990	COG5577	PFAM Coat F domain
I5818_RS07005	COG1024	Enoyl-CoA hydratase
I5818_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_RS07010	COG0183	Belongs to the thiolase family
I5818_RS07015	COG1960	acyl-CoA dehydrogenase activity
I5818_RS07020	COG1393	Belongs to the ArsC family
I5818_RS07025	COG0509	glycine decarboxylation via glycine cleavage system
I5818_RS07030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_RS07045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5818_RS07050	COG2011	ABC-type metal ion transport system permease component
I5818_RS07055	COG1464	Belongs to the NlpA lipoprotein family
I5818_RS07065	COG0396	ATPase activity
I5818_RS07070	COG0719	Fe-S assembly protein
I5818_RS07075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5818_RS07080	COG0822	iron-sulfur transferase activity
I5818_RS07085	COG0719	Fe-S assembly protein
I5818_RS07095	COG1801	Protein of unknown function DUF72
I5818_RS07145	COG0732	type I restriction modification DNA specificity domain
I5818_RS07195	COG1801	Protein of unknown function DUF72
I5818_RS07200	COG0737	Belongs to the 5'-nucleotidase family
I5818_RS07205	COG3377	Domain of unknown function (DUF1805)
I5818_RS07215	COG0733	neurotransmitter:sodium symporter activity
I5818_RS07225	COG0739	heme binding
I5818_RS07235	COG4470	Protein conserved in bacteria
I5818_RS07245	COG2445	Protein of unknown function DUF86
I5818_RS07250	COG0647	UMP catabolic process
I5818_RS07255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5818_RS07260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_RS07265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5818_RS07270	COG4837	Protein of unknown function (DUF1462)
I5818_RS07275	COG4844	belongs to the
I5818_RS07285	COG0316	Belongs to the HesB IscA family
I5818_RS07295	COG1252	NADH dehydrogenase
I5818_RS07310	COG3584	3D domain protein
I5818_RS07315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5818_RS07330	COG2050	protein possibly involved in aromatic compounds catabolism
I5818_RS07335	COG2814	Major facilitator Superfamily
I5818_RS07345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5818_RS07355	COG2032	superoxide dismutase activity
I5818_RS07360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_RS07365	COG2267	carboxylic ester hydrolase activity
I5818_RS07375	COG1098	S1 RNA binding domain
I5818_RS07380	COG3829	transcription factor binding
I5818_RS07385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5818_RS07390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_RS07395	COG2155	Conserved Protein
I5818_RS07410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5818_RS07440	COG2801	Transposase and inactivated derivatives
I5818_RS07445	COG1272	protein, Hemolysin III
I5818_RS07455	COG2814	Major facilitator Superfamily
I5818_RS07490	COG1285	pathogenesis
I5818_RS07495	COG0697	spore germination
I5818_RS07620	COG1575	Belongs to the MenA family. Type 1 subfamily
I5818_RS07625	COG1169	isochorismate synthase
I5818_RS07630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I5818_RS07635	COG0596	Alpha beta hydrolase
I5818_RS07640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I5818_RS07645	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS07650	COG4948	Mandelate Racemase Muconate Lactonizing
I5818_RS07660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5818_RS07670	COG0783	Belongs to the Dps family
I5818_RS07690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5818_RS07695	COG1116	anion transmembrane transporter activity
I5818_RS07700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5818_RS07705	COG1506	peptidase
I5818_RS07720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5818_RS07725	COG0367	asparagine synthase
I5818_RS07735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5818_RS07740	COG2267	carboxylic ester hydrolase activity
I5818_RS07750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5818_RS07765	COG2814	Major facilitator Superfamily
I5818_RS07770	COG0495	leucyl-tRNA aminoacylation
I5818_RS07780	COG3764	Sortase (surface protein transpeptidase)
I5818_RS07785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS07795	COG2081	HI0933 family
I5818_RS07800	COG2244	polysaccharide biosynthetic process
I5818_RS07810	COG1187	pseudouridine synthase activity
I5818_RS07815	COG1349	DNA-binding transcription factor activity
I5818_RS07820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_RS07840	COG1597	lipid kinase activity
I5818_RS07845	COG0510	thiamine kinase activity
I5818_RS07855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5818_RS07860	COG1368	sulfuric ester hydrolase activity
I5818_RS07870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS07875	COG1363	Peptidase, m42
I5818_RS07880	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I5818_RS07890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_RS07895	COG4848	Belongs to the UPF0354 family
I5818_RS07905	COG1674	ftsk spoiiie
I5818_RS07910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5818_RS07915	COG2309	aminopeptidase activity
I5818_RS07920	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I5818_RS07925	COG4980	gas vesicle protein
I5818_RS07935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_RS07935	COG1605	Chorismate mutase
I5818_RS07950	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5818_RS07955	COG0517	IMP dehydrogenase activity
I5818_RS07960	COG0454	-acetyltransferase
I5818_RS07965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5818_RS07975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5818_RS08015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5818_RS08020	COG5434	Belongs to the glycosyl hydrolase 28 family
I5818_RS08020	COG4632	Exopolysaccharide biosynthesis protein
I5818_RS08030	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS08035	COG0586	Pfam SNARE associated Golgi protein
I5818_RS08060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5818_RS08070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5818_RS08075	COG2199	diguanylate cyclase activity
I5818_RS08075	COG2203	Gaf domain
I5818_RS08080	COG1956	GAF domain-containing protein
I5818_RS08085	COG1309	transcriptional regulator
I5818_RS08090	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I5818_RS08095	COG1104	cysteine desulfurase activity
I5818_RS08100	COG0301	tRNA thio-modification
I5818_RS08115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5818_RS08120	COG2962	Rard protein
I5818_RS08125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5818_RS08130	COG0616	signal peptide processing
I5818_RS08135	COG1714	RDD family
I5818_RS08145	COG3874	Sporulation protein YtfJ
I5818_RS08150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5818_RS08155	COG0827	DNA restriction-modification system
I5818_RS08160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5818_RS08170	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5818_RS08175	COG0006	proline dipeptidase activity
I5818_RS08190	COG4109	DRTGG domain
I5818_RS08200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5818_RS08215	COG0587	DNA-directed DNA polymerase activity
I5818_RS08220	COG0281	malic enzyme
I5818_RS08225	COG2186	Transcriptional regulator
I5818_RS08230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5818_RS08235	COG0825	malonyl-CoA metabolic process
I5818_RS08240	COG0205	6-phosphofructokinase activity
I5818_RS08250	COG0628	permease
I5818_RS08255	COG0372	Belongs to the citrate synthase family
I5818_RS08260	COG0538	isocitrate dehydrogenase activity
I5818_RS08265	COG0039	L-malate dehydrogenase activity
I5818_RS08275	COG0330	HflC and HflK could
I5818_RS08280	COG0330	HflC and HflK could
I5818_RS08285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_RS08285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_RS08290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5818_RS08295	COG1971	Probably functions as a manganese efflux pump
I5818_RS08305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5818_RS08310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5818_RS08315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5818_RS08320	COG3611	Membrane attachment protein
I5818_RS08325	COG1484	DNA-dependent DNA replication
I5818_RS08335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_RS08340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I5818_RS08345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5818_RS08350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5818_RS08360	COG0398	Pfam SNARE associated Golgi protein
I5818_RS08370	COG1363	Peptidase, m42
I5818_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5818_RS08385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5818_RS08395	COG0670	Belongs to the BI1 family
I5818_RS08405	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I5818_RS08410	COG1286	toxin biosynthetic process
I5818_RS08415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5818_RS08415	COG1796	DNA polymerase
I5818_RS08420	COG1193	negative regulation of DNA recombination
I5818_RS08425	COG3766	membrane
I5818_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS08435	COG1309	transcriptional regulator
I5818_RS08440	COG1024	Enoyl-CoA hydratase
I5818_RS08445	COG2086	electron transfer activity
I5818_RS08450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5818_RS08455	COG3336	cytochrome c oxidase
I5818_RS08460	COG2217	Heavy metal translocating P-type atpase
I5818_RS08465	COG3118	belongs to the thioredoxin family
I5818_RS08470	COG0322	excinuclease ABC activity
I5818_RS08480	COG1719	4-vinyl reductase, 4VR
I5818_RS08485	COG2009	succinate dehydrogenase
I5818_RS08490	COG1053	succinate dehydrogenase
I5818_RS08495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5818_RS08500	COG0824	Thioesterase
I5818_RS08505	COG2197	response regulator
I5818_RS08510	COG1846	Transcriptional regulator
I5818_RS08520	COG5401	PFAM Sporulation and spore germination
I5818_RS08525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5818_RS08535	COG0622	Phosphoesterase
I5818_RS08545	COG1477	protein flavinylation
I5818_RS08545	COG0457	Tetratricopeptide repeat
I5818_RS08550	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5818_RS08555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5818_RS08565	COG1067	ATP-dependent peptidase activity
I5818_RS08565	COG0470	DNA polymerase III
I5818_RS08570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5818_RS08575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5818_RS08590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_RS08595	COG0181	hydroxymethylbilane synthase activity
I5818_RS08605	COG0113	porphobilinogen synthase activity
I5818_RS08610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5818_RS08615	COG1388	LysM domain
I5818_RS08615	COG1388	LysM domain
I5818_RS08620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_RS08630	COG0525	valine-tRNA ligase activity
I5818_RS08635	COG0285	dihydrofolate synthase activity
I5818_RS08645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5818_RS08655	COG0424	maF-like protein
I5818_RS08660	COG2003	Belongs to the UPF0758 family
I5818_RS08665	COG1077	Cell shape determining protein MreB Mrl
I5818_RS08670	COG1792	Involved in formation and maintenance of cell shape
I5818_RS08675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5818_RS08680	COG0850	regulation of cytokinetic process
I5818_RS08685	COG2894	cell division
I5818_RS08690	COG0739	heme binding
I5818_RS08695	COG1994	Peptidase M50
I5818_RS08705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5818_RS08710	COG2868	ribosomal protein
I5818_RS08715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5818_RS08720	COG3290	protein histidine kinase activity
I5818_RS08725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5818_RS08730	COG4492	Belongs to the UPF0735 family
I5818_RS08735	COG0077	Prephenate dehydratase
I5818_RS08740	COG1827	regulation of RNA biosynthetic process
I5818_RS08745	COG1388	LysM domain
I5818_RS08765	COG0632	four-way junction helicase activity
I5818_RS08775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5818_RS08785	COG1862	Preprotein translocase
I5818_RS08795	COG2323	membrane
I5818_RS08800	COG2244	polysaccharide biosynthetic process
I5818_RS08810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5818_RS08810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5818_RS08815	COG0300	oxidoreductase activity
I5818_RS08830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5818_RS08830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5818_RS08835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5818_RS08840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5818_RS08850	COG4991	sh3 domain protein
I5818_RS08850	COG3103	Sh3 type 3 domain protein
I5818_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS08860	COG0124	histidyl-tRNA synthetase
I5818_RS08865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5818_RS08875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5818_RS08885	COG1725	Transcriptional regulator
I5818_RS08890	COG1131	(ABC) transporter
I5818_RS08895	COG1131	(ABC) transporter
I5818_RS08900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_RS08905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5818_RS08910	COG1959	2 iron, 2 sulfur cluster binding
I5818_RS08915	COG1104	cysteine desulfurase activity
I5818_RS08930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5818_RS08955	COG0628	permease
I5818_RS08965	COG4472	Bacterial protein of unknown function (DUF965)
I5818_RS08975	COG3906	Belongs to the UPF0473 family
I5818_RS08985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5818_RS08990	COG4122	O-methyltransferase activity
I5818_RS08995	COG0572	uridine kinase
I5818_RS09000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5818_RS09005	COG0768	penicillin binding
I5818_RS09020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5818_RS09030	COG1566	PFAM secretion protein HlyD family protein
I5818_RS09035	COG2814	Major facilitator Superfamily
I5818_RS09060	COG1183	phosphatidylcholine synthase activity
I5818_RS09065	COG0688	phosphatidylethanolamine metabolic process
I5818_RS09075	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I5818_RS09080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5818_RS09090	COG1534	Rna-binding protein
I5818_RS09095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5818_RS09100	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5818_RS09105	COG0799	negative regulation of ribosome biogenesis
I5818_RS09110	COG2226	methyltransferase
I5818_RS09115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5818_RS09120	COG1555	photosystem II stabilization
I5818_RS09120	COG1596	polysaccharide export
I5818_RS09125	COG2131	deaminase
I5818_RS09130	COG2333	competence protein COMEC
I5818_RS09130	COG0658	competence protein
I5818_RS09140	COG1466	dna polymerase III delta subunit
I5818_RS09145	COG0268	Binds directly to 16S ribosomal RNA
I5818_RS09155	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS09165	COG0481	GTPase activity
I5818_RS09170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5818_RS09175	COG1420	regulation of RNA biosynthetic process
I5818_RS09180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5818_RS09185	COG0443	Heat shock 70 kDa protein
I5818_RS09195	COG2264	protein methyltransferase activity
I5818_RS09200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5818_RS09205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5818_RS09210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5818_RS09215	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5818_RS09220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5818_RS09225	COG1610	YqeY-like protein
I5818_RS09230	COG1030	water channel activity
I5818_RS09235	COG4864	UPF0365 protein
I5818_RS09255	COG1702	phosphate starvation-inducible protein PhoH
I5818_RS09260	COG1480	7TM receptor with intracellular HD hydrolase
I5818_RS09270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5818_RS09275	COG0295	cytidine deaminase activity
I5818_RS09280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5818_RS09290	COG1381	Involved in DNA repair and RecF pathway recombination
I5818_RS09295	COG0517	IMP dehydrogenase activity
I5818_RS09305	COG1671	Belongs to the UPF0178 family
I5818_RS09310	COG0358	DNA primase activity
I5818_RS09315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5818_RS09325	COG1960	acyl-CoA dehydrogenase activity
I5818_RS09330	COG2010	Cytochrome c
I5818_RS09335	COG2384	SAM-dependent methyltransferase
I5818_RS09340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5818_RS09345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5818_RS09355	COG0513	Belongs to the DEAD box helicase family
I5818_RS09360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I5818_RS09370	COG0735	belongs to the Fur family
I5818_RS09375	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I5818_RS09380	COG4709	membrane
I5818_RS09385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5818_RS09395	COG5521	maltodextrose utilization protein MalA
I5818_RS09405	COG0477	Major facilitator Superfamily
I5818_RS09410	COG0768	penicillin binding
I5818_RS09415	COG0768	penicillin binding
I5818_RS09435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_RS09440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5818_RS09450	COG0457	Tetratricopeptide repeat
I5818_RS09450	COG0705	Rhomboid family
I5818_RS09460	COG4483	Protein conserved in bacteria
I5818_RS09465	COG1940	carbohydrate kinase activity
I5818_RS09470	COG1368	sulfuric ester hydrolase activity
I5818_RS09485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS09495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5818_RS09500	COG1459	type II secretion system
I5818_RS09505	COG4537	Required for transformation and DNA binding
I5818_RS09545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_RS09550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5818_RS09555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_RS09560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_RS09565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS09570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_RS09580	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5818_RS09590	COG3872	metal-dependent enzyme
I5818_RS09600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5818_RS09605	COG0006	proline dipeptidase activity
I5818_RS09610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5818_RS09615	COG3854	ATPases associated with a variety of cellular activities
I5818_RS09655	COG0511	ligase activity, forming carbon-carbon bonds
I5818_RS09660	COG0439	Biotin carboxylase
I5818_RS09665	COG1302	Protein conserved in bacteria
I5818_RS09690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5818_RS09695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I5818_RS09705	COG0497	DNA recombination
I5818_RS09710	COG0750	zinc metalloprotease
I5818_RS09725	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_RS09740	COG3829	transcription factor binding
I5818_RS09740	COG3290	protein histidine kinase activity
I5818_RS09745	COG0280	phosphate acetyltransferase
I5818_RS09755	COG3426	butyrate kinase activity
I5818_RS09760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5818_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5818_RS09770	COG0022	dehydrogenase e1 component
I5818_RS09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5818_RS09780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_RS09785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_RS09785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_RS09790	COG1703	isobutyryl-CoA mutase activity
I5818_RS09805	COG0346	lactoylglutathione lyase activity
I5818_RS09810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5818_RS09820	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5818_RS09825	COG0835	chemotaxis
I5818_RS09825	COG0784	Response regulator, receiver
I5818_RS09835	COG5506	Protein of unknown function (DUF1694)
I5818_RS09840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5818_RS09845	COG1234	tRNA 3'-trailer cleavage
I5818_RS09850	COG1902	pentaerythritol trinitrate reductase activity
I5818_RS09855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5818_RS09860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS09865	COG0300	oxidoreductase activity
I5818_RS09870	COG1473	amidohydrolase
I5818_RS09875	COG1757	Na H antiporter
I5818_RS09910	COG0109	protoheme IX farnesyltransferase activity
I5818_RS09915	COG0656	L-ascorbic acid biosynthetic process
I5818_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS09950	COG1073	alpha beta
I5818_RS09955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5818_RS09960	COG3853	Toxic anion resistance protein (TelA)
I5818_RS09965	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I5818_RS09975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5818_RS09980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5818_RS10000	COG0667	Aldo Keto reductase
I5818_RS10015	COG1379	DNA repair
I5818_RS10025	COG1300	Membrane
I5818_RS10030	COG0735	belongs to the Fur family
I5818_RS10040	COG4974	Belongs to the 'phage' integrase family
I5818_RS10060	COG1686	Belongs to the peptidase S11 family
I5818_RS10095	COG0697	spore germination
I5818_RS10110	COG1547	Domain of unknown function (DUF309)
I5818_RS10125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5818_RS10130	COG1686	Belongs to the peptidase S11 family
I5818_RS10135	COG2715	membrane protein required for spore maturation
I5818_RS10140	COG0700	Nucleoside recognition
I5818_RS10145	COG1187	pseudouridine synthase activity
I5818_RS10150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_RS10155	COG1333	cytochrome c biogenesis protein
I5818_RS10160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_RS10165	COG0745	RESPONSE REGULATOR receiver
I5818_RS10170	COG5002	protein histidine kinase activity
I5818_RS10175	COG1595	DNA-templated transcription, initiation
I5818_RS10185	COG0739	heme binding
I5818_RS10190	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I5818_RS10195	COG1141	Ferredoxin
I5818_RS10200	COG4955	Helix-turn-helix domain
I5818_RS10205	COG0514	ATP-dependent DNA helicase (RecQ)
I5818_RS10210	COG1266	CAAX protease self-immunity
I5818_RS10225	COG3546	catalase activity
I5818_RS10245	COG1408	metallophosphoesterase
I5818_RS10255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_RS10260	COG0492	ferredoxin-NADP+ reductase activity
I5818_RS10265	COG0252	asparaginase activity
I5818_RS10270	COG2339	peptidase activity
I5818_RS10275	COG3773	Cell wall hydrolase
I5818_RS10275	COG3409	Peptidoglycan-binding domain 1 protein
I5818_RS10280	COG2959	enzyme of heme biosynthesis
I5818_RS10295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5818_RS10305	COG0539	negative regulation of cytoplasmic translation
I5818_RS10325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5818_RS10340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5818_RS10350	COG0302	gtp cyclohydrolase
I5818_RS10355	COG0142	geranyltranstransferase activity
I5818_RS10360	COG2226	methyltransferase
I5818_RS10365	COG0142	geranyltranstransferase activity
I5818_RS10370	COG0105	UTP biosynthetic process
I5818_RS10375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5818_RS10385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5818_RS10390	COG4401	Chorismate mutase type I
I5818_RS10395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_RS10400	COG0287	Prephenate dehydrogenase
I5818_RS10405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5818_RS10415	COG0457	Tetratricopeptide repeat
I5818_RS10420	COG5582	Belongs to the UPF0302 family
I5818_RS10435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5818_RS10445	COG4347	Protein of unknown function (DUF1405)
I5818_RS10455	COG2738	Putative neutral zinc metallopeptidase
I5818_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS10465	COG1694	Mazg nucleotide pyrophosphohydrolase
I5818_RS10470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5818_RS10475	COG1803	Methylglyoxal synthase
I5818_RS10480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5818_RS10485	COG0438	transferase activity, transferring glycosyl groups
I5818_RS10490	COG0617	tRNA 3'-terminal CCA addition
I5818_RS10500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5818_RS10505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5818_RS10510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I5818_RS10515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5818_RS10515	COG1199	ATP-dependent helicase activity
I5818_RS10530	COG0436	Aminotransferase
I5818_RS10535	COG0017	Asparaginyl-tRNA synthetase
I5818_RS10540	COG3935	DnaD domain protein
I5818_RS10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5818_RS10550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_RS10550	COG4499	WXG100 protein secretion system (Wss), protein YukC
I5818_RS10580	COG1111	helicase
I5818_RS10580	COG1205	dead DEAH box helicase
I5818_RS10585	COG3359	exonuclease
I5818_RS10610	COG0116	Belongs to the methyltransferase superfamily
I5818_RS10620	COG1199	ATP-dependent helicase activity
I5818_RS10625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5818_RS10635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_RS10640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5818_RS10655	COG2233	PERMEase
I5818_RS10660	COG1476	TRANSCRIPTIONal
I5818_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS10690	COG3424	synthase
I5818_RS10695	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5818_RS10700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5818_RS10715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_RS10730	COG0328	RNA-DNA hybrid ribonuclease activity
I5818_RS10735	COG0328	RNA-DNA hybrid ribonuclease activity
I5818_RS10750	COG1321	iron dependent repressor
I5818_RS10755	COG2226	methyltransferase
I5818_RS10795	COG1418	mRNA catabolic process
I5818_RS10800	COG0488	(ABC) transporter
I5818_RS10805	COG1413	lyase activity
I5818_RS10815	COG2521	methyltransferase
I5818_RS10815	COG2136	Putative SAM-dependent methyltransferase
I5818_RS10830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5818_RS10835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_RS10840	COG1272	protein, Hemolysin III
I5818_RS10870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5818_RS10880	COG0840	transmembrane signaling receptor activity
I5818_RS10885	COG4479	Belongs to the UPF0346 family
I5818_RS10915	COG1876	peptidase activity
I5818_RS10920	COG0793	Belongs to the peptidase S41A family
I5818_RS10920	COG3409	Peptidoglycan-binding domain 1 protein
I5818_RS10935	COG2340	Cysteine-rich secretory protein family
I5818_RS10955	COG0586	Pfam SNARE associated Golgi protein
I5818_RS10975	COG1131	(ABC) transporter
I5818_RS10995	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I5818_RS11000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5818_RS11005	COG1793	dna ligase
I5818_RS11005	COG3285	dna ligase
I5818_RS11010	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I5818_RS11015	COG0671	phosphoesterase, PA-phosphatase related
I5818_RS11025	COG1278	Cold shock
I5818_RS11030	COG1368	sulfuric ester hydrolase activity
I5818_RS11035	COG1280	lysine exporter protein (LysE YggA)
I5818_RS11050	COG1113	amino acid transport
I5818_RS11065	COG2814	Major facilitator Superfamily
I5818_RS11095	COG0596	Alpha beta hydrolase
I5818_RS11105	COG4145	pantothenate transmembrane transporter activity
I5818_RS11110	COG2258	MOSC domain
I5818_RS11115	COG0444	Belongs to the ABC transporter superfamily
I5818_RS11120	COG4608	Belongs to the ABC transporter superfamily
I5818_RS11125	COG0747	negative chemotaxis
I5818_RS11130	COG0601	transmembrane transport
I5818_RS11135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS11140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_RS11145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_RS11155	COG0745	RESPONSE REGULATOR receiver
I5818_RS11160	COG5002	protein histidine kinase activity
I5818_RS11170	COG0567	Dehydrogenase, E1 component
I5818_RS11175	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5818_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS11215	COG0714	Associated with various cellular activities
I5818_RS11220	COG4548	von Willebrand factor, type A
I5818_RS11230	COG1686	Belongs to the peptidase S11 family
I5818_RS11235	COG2181	nitrate reductase activity
I5818_RS11240	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5818_RS11245	COG1140	nitrate reductase beta subunit
I5818_RS11250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5818_RS11255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5818_RS11260	COG2223	nitrite transmembrane transporter activity
I5818_RS11265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5818_RS11270	COG0303	'Molybdopterin
I5818_RS11275	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5818_RS11300	COG2223	nitrite transmembrane transporter activity
I5818_RS11315	COG0392	lysyltransferase activity
I5818_RS11315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I5818_RS11320	COG1054	Belongs to the UPF0176 family
I5818_RS11325	COG0392	lysyltransferase activity
I5818_RS11325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I5818_RS11330	COG1164	Oligoendopeptidase f
I5818_RS11345	COG2323	membrane
I5818_RS11350	COG2368	4-hydroxyphenylacetate
I5818_RS11355	COG0488	(ABC) transporter
I5818_RS11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_RS11370	COG0723	plastoquinol--plastocyanin reductase activity
I5818_RS11375	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I5818_RS11385	COG3594	Acyltransferase
I5818_RS11390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS11395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_RS11400	COG0730	response to heat
I5818_RS11415	COG2814	Major facilitator Superfamily
I5818_RS11425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5818_RS11435	COG0463	Glycosyl transferase, family 2
I5818_RS11450	COG1809	phosphosulfolactate synthase activity
I5818_RS11460	COG0175	sulfate reduction
I5818_RS11465	COG2046	Belongs to the sulfate adenylyltransferase family
I5818_RS11470	COG0529	Catalyzes the synthesis of activated sulfate
I5818_RS11475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS11485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5818_RS11495	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_RS11500	COG1121	(ABC) transporter
I5818_RS11505	COG1321	iron dependent repressor
I5818_RS11505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_RS11510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_RS11535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5818_RS11540	COG0131	Imidazoleglycerol-phosphate dehydratase
I5818_RS11545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5818_RS11555	COG0107	imidazoleglycerol-phosphate synthase activity
I5818_RS11560	COG0140	phosphoribosyl-ATP diphosphatase activity
I5818_RS11560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5818_RS11580	COG0697	spore germination
I5818_RS11595	COG0673	inositol 2-dehydrogenase activity
I5818_RS11600	COG0494	nUDIX hydrolase
I5818_RS11605	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_RS11610	COG1121	(ABC) transporter
I5818_RS11615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_RS11620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5818_RS11625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS11660	COG2217	Heavy metal translocating P-type atpase
I5818_RS11665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5818_RS11680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_RS11695	COG1278	Cold shock
I5818_RS11720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_RS11725	COG0697	spore germination
I5818_RS11755	COG0693	protein deglycase activity
I5818_RS11760	COG2378	regulation of single-species biofilm formation
I5818_RS11785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_RS11785	COG1605	Chorismate mutase
I5818_RS11795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5818_RS11800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_RS11805	COG0287	Prephenate dehydrogenase
I5818_RS11830	COG1271	oxidase subunit
I5818_RS11835	COG1294	oxidase, subunit
I5818_RS11865	COG0488	(ABC) transporter
I5818_RS11885	COG0494	nUDIX hydrolase
I5818_RS11890	COG1335	isochorismatase
I5818_RS11895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5818_RS11900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5818_RS11905	COG2733	membrane
I5818_RS11910	COG3647	Membrane
I5818_RS11930	COG2124	cytochrome p450
I5818_RS11935	COG1247	-acetyltransferase
I5818_RS11945	COG1051	belongs to the nudix hydrolase family
I5818_RS11945	COG1056	cytidyltransferase-related domain
I5818_RS11950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5818_RS11955	COG1595	DNA-templated transcription, initiation
I5818_RS11965	COG0772	Belongs to the SEDS family
I5818_RS12050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_RS12065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5818_RS12100	COG1595	DNA-templated transcription, initiation
I5818_RS12120	COG1131	(ABC) transporter
I5818_RS12125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_RS12130	COG1131	(ABC) transporter
I5818_RS12190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5818_RS12195	COG1193	negative regulation of DNA recombination
I5818_RS12200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5818_RS12205	COG0598	Magnesium transport protein CorA
I5818_RS12240	COG1725	Transcriptional regulator
I5818_RS12245	COG1131	(ABC) transporter
I5818_RS12265	COG3773	Cell wall hydrolase
I5818_RS12270	COG5577	PFAM Coat F domain
I5818_RS12290	COG0708	Exodeoxyribonuclease III
I5818_RS12295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5818_RS12305	COG0488	(ABC) transporter
I5818_RS12330	COG1609	Transcriptional regulator
I5818_RS12340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5818_RS12345	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I5818_RS12370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_RS12400	COG3852	Histidine kinase
I5818_RS12405	COG0656	L-ascorbic acid biosynthetic process
I5818_RS12410	COG4555	ABC transporter
I5818_RS12425	COG2072	flavoprotein involved in K transport
I5818_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS12435	COG0657	acetylesterase activity
I5818_RS12460	COG0768	penicillin binding
I5818_RS12465	COG0768	penicillin binding
I5818_RS12485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_RS12490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5818_RS12495	COG0187	DNA topoisomerase II activity
I5818_RS12500	COG1832	CoA-binding protein
I5818_RS12505	COG2233	PERMEase
I5818_RS12510	COG3858	chitin binding
I5818_RS12515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5818_RS12520	COG2843	Capsule synthesis protein
I5818_RS12525	COG4841	protein insertion into membrane
I5818_RS12535	COG0824	Thioesterase
I5818_RS12555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_RS12560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5818_RS12565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS12585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5818_RS12590	COG0739	heme binding
I5818_RS12595	COG1346	cytolysis
I5818_RS12600	COG1380	Effector of murein hydrolase LrgA
I5818_RS12605	COG2427	Protein of unknown function (DUF1641)
I5818_RS12610	COG1510	regulation of RNA biosynthetic process
I5818_RS12615	COG0517	IMP dehydrogenase activity
I5818_RS12615	COG4175	Glycine betaine
I5818_RS12620	COG4176	ABC-type proline glycine betaine transport system permease component
I5818_RS12625	COG2113	Glycine betaine
I5818_RS12640	COG3314	Sporulation integral membrane protein YlbJ
I5818_RS12645	COG1228	amidohydrolase
I5818_RS12650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5818_RS12655	COG3162	membrane
I5818_RS12660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_RS12665	COG0312	modulator of DNA gyrase
I5818_RS12670	COG0312	modulator of DNA gyrase
I5818_RS12675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS12675	COG2207	Transcriptional regulator
I5818_RS12680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_RS12685	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_RS12695	COG2030	dehydratase
I5818_RS12700	COG1914	H( )-stimulated, divalent metal cation uptake system
I5818_RS12705	COG1473	amidohydrolase
I5818_RS12715	COG0840	transmembrane signaling receptor activity
I5818_RS12720	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS12730	COG0386	Belongs to the glutathione peroxidase family
I5818_RS12735	COG0783	Belongs to the Dps family
I5818_RS12765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS12780	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I5818_RS12785	COG0709	Synthesizes selenophosphate from selenide and ATP
I5818_RS12790	COG0701	Predicted permease
I5818_RS12800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5818_RS12815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5818_RS12825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5818_RS12840	COG0438	transferase activity, transferring glycosyl groups
I5818_RS12845	COG1132	(ABC) transporter
I5818_RS12850	COG1216	Glycosyl transferase, family 2
I5818_RS12850	COG1442	glycosyl transferase family 8
I5818_RS12875	COG1086	Polysaccharide biosynthesis protein
I5818_RS12885	COG4464	protein tyrosine phosphatase activity
I5818_RS12890	COG0489	protein tyrosine kinase activity
I5818_RS12895	COG3944	biosynthesis protein
I5818_RS12910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5818_RS12915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5818_RS12945	COG0477	Major facilitator Superfamily
I5818_RS12950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_RS12955	COG0733	neurotransmitter:sodium symporter activity
I5818_RS12985	COG3239	Fatty acid desaturase
I5818_RS12990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5818_RS13000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_RS13005	COG0322	excinuclease ABC activity
I5818_RS13010	COG1879	ABC-type sugar transport system periplasmic component
I5818_RS13015	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5818_RS13020	COG1129	ABC transporter
I5818_RS13030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5818_RS13035	COG1609	Transcriptional regulator
I5818_RS13045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5818_RS13050	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS13055	COG2508	Transcriptional regulator
I5818_RS13085	COG0697	spore germination
I5818_RS13110	COG0493	'glutamate synthase
I5818_RS13195	COG1595	DNA-templated transcription, initiation
I5818_RS13205	COG5001	Diguanylate cyclase
I5818_RS13215	COG1309	transcriptional regulator
I5818_RS13220	COG0477	Major facilitator Superfamily
I5818_RS13235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5818_RS13245	COG0716	FMN binding
I5818_RS13280	COG1506	peptidase
I5818_RS13290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5818_RS13295	COG0436	Aminotransferase
I5818_RS13305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_RS13350	COG1115	amino acid carrier protein
I5818_RS13355	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I5818_RS13360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_RS13365	COG0778	Nitroreductase
I5818_RS13385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5818_RS13400	COG1304	FMN binding
I5818_RS13415	COG0010	Belongs to the arginase family
I5818_RS13425	COG2814	Major facilitator Superfamily
I5818_RS13435	COG1346	cytolysis
I5818_RS13440	COG1380	Effector of murein hydrolase LrgA
I5818_RS13445	COG1846	Transcriptional regulator
I5818_RS13495	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5818_RS13515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5818_RS13520	COG0352	thiamine-phosphate diphosphorylase activity
I5818_RS13525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I5818_RS13530	COG0352	thiamine-phosphate diphosphorylase activity
I5818_RS13530	COG0351	phosphomethylpyrimidine kinase
I5818_RS13555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_RS13565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5818_RS13570	COG2315	Protein conserved in bacteria
I5818_RS13585	COG0582	viral genome integration into host DNA
I5818_RS13590	COG0490	domain, Protein
I5818_RS13595	COG0475	glutathione-regulated potassium exporter activity
I5818_RS13650	COG0456	acetyltransferase
I5818_RS13650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5818_RS13675	COG2816	NAD+ diphosphatase activity
I5818_RS13700	COG1396	sequence-specific DNA binding
I5818_RS13710	COG4608	Belongs to the ABC transporter superfamily
I5818_RS13715	COG0444	Belongs to the ABC transporter superfamily
I5818_RS13720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS13725	COG0601	transmembrane transport
I5818_RS13730	COG0747	negative chemotaxis
I5818_RS13735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_RS13740	COG0492	ferredoxin-NADP+ reductase activity
I5818_RS13745	COG1120	ATPase activity
I5818_RS13750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS13755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS13765	COG2252	PERMEase
I5818_RS13770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS13770	COG3711	transcriptional antiterminator
I5818_RS13780	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_RS13785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS13790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS13795	COG1486	melibiose metabolic process
I5818_RS13800	COG3663	DNA glycosylase
I5818_RS13820	COG0534	Mate efflux family protein
I5818_RS13835	COG0346	lactoylglutathione lyase activity
I5818_RS13840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS13845	COG0006	proline dipeptidase activity
I5818_RS13850	COG3428	Bacterial PH domain
I5818_RS13910	COG1357	PFAM Pentapeptide repeats (8 copies)
I5818_RS13915	COG0500	methyltransferase
I5818_RS13935	COG1725	Transcriptional regulator
I5818_RS13940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5818_RS13970	COG2372	response to copper ion
I5818_RS13975	COG1349	DNA-binding transcription factor activity
I5818_RS13980	COG1115	amino acid carrier protein
I5818_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS14020	COG0406	alpha-ribazole phosphatase activity
I5818_RS14055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_RS14065	COG0456	acetyltransferase
I5818_RS14100	COG0406	alpha-ribazole phosphatase activity
I5818_RS14120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_RS14135	COG2329	Antibiotic biosynthesis monooxygenase
I5818_RS14145	COG1794	racemase activity, acting on amino acids and derivatives
I5818_RS14155	COG5566	PFAM Mor transcription activator
I5818_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS14190	COG2323	membrane
I5818_RS14205	COG0477	Major facilitator Superfamily
I5818_RS14235	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I5818_RS14240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS14245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_RS14250	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_RS14270	COG2226	methyltransferase
I5818_RS14305	COG2318	DinB family
I5818_RS14315	COG4106	trans-aconitate 2-methyltransferase activity
I5818_RS14355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5818_RS14375	COG0456	acetyltransferase
I5818_RS14385	COG1335	isochorismatase
I5818_RS14390	COG0697	spore germination
I5818_RS14395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_RS14410	COG2271	Major facilitator Superfamily
I5818_RS14420	COG3420	alginic acid biosynthetic process
I5818_RS14440	COG0745	RESPONSE REGULATOR receiver
I5818_RS14445	COG2205	protein histidine kinase activity
I5818_RS14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_RS14490	COG0456	acetyltransferase
I5818_RS14510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5818_RS14515	COG1268	BioY protein
I5818_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS14525	COG0183	Belongs to the thiolase family
I5818_RS14555	COG1525	nuclease
I5818_RS14575	COG3655	Transcriptional regulator
I5818_RS14595	COG3541	Predicted nucleotidyltransferase
I5818_RS14600	COG0431	NADPH-dependent FMN reductase
I5818_RS14630	COG0673	inositol 2-dehydrogenase activity
I5818_RS14635	COG1051	belongs to the nudix hydrolase family
I5818_RS14665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_RS14675	COG1732	Glycine betaine
I5818_RS14680	COG1174	glycine betaine transport
I5818_RS14685	COG0517	IMP dehydrogenase activity
I5818_RS14685	COG1125	glycine betaine transport
I5818_RS14690	COG1510	regulation of RNA biosynthetic process
I5818_RS14695	COG3011	Protein conserved in bacteria
I5818_RS14700	COG1607	acyl-coa hydrolase
I5818_RS14705	COG1285	pathogenesis
I5818_RS14710	COG2814	Major facilitator Superfamily
I5818_RS14715	COG0583	DNA-binding transcription factor activity
I5818_RS14745	COG2814	Major facilitator Superfamily
I5818_RS14750	COG2814	Major facilitator Superfamily
I5818_RS14760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5818_RS14770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5818_RS14780	COG1136	(ABC) transporter
I5818_RS14785	COG0577	efflux transmembrane transporter activity
I5818_RS14805	COG2271	Major facilitator Superfamily
I5818_RS14810	COG0277	FAD linked oxidase domain protein
I5818_RS14815	COG2066	Belongs to the glutaminase family
I5818_RS14825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5818_RS14850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5818_RS14855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5818_RS14855	COG0512	Glutamine amidotransferase of anthranilate synthase
I5818_RS14865	COG2226	methyltransferase
I5818_RS14880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_RS14900	COG1396	sequence-specific DNA binding
I5818_RS14910	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS14915	COG2211	Major facilitator Superfamily
I5818_RS14935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_RS14945	COG0165	Argininosuccinate lyase
I5818_RS14950	COG0137	argininosuccinate synthase activity
I5818_RS14955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5818_RS14965	COG0505	Belongs to the CarA family
I5818_RS14970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5818_RS14975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5818_RS14980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5818_RS14985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5818_RS15010	COG2226	methyltransferase
I5818_RS15015	COG0601	transmembrane transport
I5818_RS15045	COG0419	ATPase involved in DNA repair
I5818_RS15050	COG0420	3'-5' exonuclease activity
I5818_RS15055	COG0204	Acyl-transferase
I5818_RS15075	COG4846	Membrane protein involved in cytochrome C biogenesis
I5818_RS15080	COG2201	protein-glutamate methylesterase activity
I5818_RS15085	COG0785	Cytochrome C biogenesis protein
I5818_RS15095	COG1132	(ABC) transporter
I5818_RS15100	COG1132	(ABC) transporter
I5818_RS15115	COG1595	DNA-templated transcription, initiation
I5818_RS15125	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_RS15135	COG1999	signal sequence binding
I5818_RS15165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_RS15170	COG1388	LysM domain
I5818_RS15175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5818_RS15190	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5818_RS15190	COG3409	Peptidoglycan-binding domain 1 protein
I5818_RS15245	COG0174	glutamine synthetase
I5818_RS15250	COG0789	Transcriptional regulator
I5818_RS15255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I5818_RS15260	COG2860	membrane
I5818_RS15265	COG0464	growth
I5818_RS15270	COG1923	regulation of RNA biosynthetic process
I5818_RS15275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5818_RS15295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS15300	COG2076	Multidrug Resistance protein
I5818_RS15305	COG2076	Multidrug Resistance protein
I5818_RS15325	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5818_RS15370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5818_RS15375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5818_RS15385	COG4550	Control of competence regulator ComK, YlbF/YmcA
I5818_RS15390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5818_RS15395	COG2359	stage V sporulation protein S
I5818_RS15400	COG1692	metallophosphoesterase
I5818_RS15415	COG1058	Belongs to the CinA family
I5818_RS15415	COG1546	Belongs to the CinA family
I5818_RS15420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5818_RS15425	COG1426	Protein conserved in bacteria
I5818_RS15440	COG0300	oxidoreductase activity
I5818_RS15445	COG0612	Peptidase, M16
I5818_RS15450	COG0612	Peptidase, M16
I5818_RS15455	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5818_RS15460	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5818_RS15465	COG3845	ABC transporter
I5818_RS15470	COG1744	ABC transporter substrate-binding protein PnrA-like
I5818_RS15475	COG2188	Transcriptional regulator
I5818_RS15480	COG1674	ftsk spoiiie
I5818_RS15480	COG4980	gas vesicle protein
I5818_RS15490	COG0740	serine-type endopeptidase activity
I5818_RS15500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5818_RS15505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_RS15520	COG0527	aspartate kinase activity
I5818_RS15525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5818_RS15530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_RS15535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_RS15540	COG1873	PFAM PRC-barrel domain
I5818_RS15545	COG0612	Peptidase, M16
I5818_RS15550	COG0726	polysaccharide deacetylase
I5818_RS15555	COG1185	polyribonucleotide nucleotidyltransferase activity
I5818_RS15560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5818_RS15565	COG0196	riboflavin kinase activity
I5818_RS15570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5818_RS15575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5818_RS15580	COG1550	Protein conserved in bacteria
I5818_RS15585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5818_RS15590	COG1358	cellular component organization or biogenesis
I5818_RS15595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5818_RS15600	COG0195	Participates in both transcription termination and antitermination
I5818_RS15605	COG0779	Required for maturation of 30S ribosomal subunits
I5818_RS15610	COG2176	DNA-directed DNA polymerase activity
I5818_RS15615	COG0750	zinc metalloprotease
I5818_RS15620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5818_RS15625	COG4589	Belongs to the CDS family
I5818_RS15635	COG0233	cytoplasmic translational termination
I5818_RS15640	COG0528	UMP kinase activity
I5818_RS15665	COG1191	sigma factor activity
I5818_RS15670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I5818_RS15675	COG1776	CheC inhibitor of MCP methylation
I5818_RS15680	COG0835	chemotaxis
I5818_RS15685	COG2198	Histidine kinase
I5818_RS15685	COG0643	Histidine kinase
I5818_RS15690	COG2201	protein-glutamate methylesterase activity
I5818_RS15695	COG0455	bacterial-type flagellum organization
I5818_RS15700	COG1419	protein localization to endoplasmic reticulum
I5818_RS15705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5818_RS15710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5818_RS15715	COG1684	flagellar biosynthetic protein fliR
I5818_RS15720	COG1987	bacterial-type flagellum assembly
I5818_RS15725	COG1338	Plays a role in the flagellum-specific transport system
I5818_RS15730	COG3190	flagellar
I5818_RS15735	COG2201	protein-glutamate methylesterase activity
I5818_RS15740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_RS15740	COG1776	CheC inhibitor of MCP methylation
I5818_RS15745	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_RS15750	COG1580	Controls the rotational direction of flagella during chemotaxis
I5818_RS15755	COG1582	Flagellar protein (FlbD)
I5818_RS15760	COG4786	Flagellar basal body rod
I5818_RS15770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I5818_RS15790	COG1157	protein secretion by the type III secretion system
I5818_RS15795	COG1317	bacterial-type flagellum organization
I5818_RS15800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_RS15805	COG1766	The M ring may be actively involved in energy transduction
I5818_RS15810	COG1677	Flagellar hook-basal body complex protein FliE
I5818_RS15815	COG1558	bacterial-type flagellum-dependent cell motility
I5818_RS15820	COG1815	bacterial-type flagellum-dependent cell motility
I5818_RS15825	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5818_RS15830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5818_RS15835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5818_RS15840	COG4974	Belongs to the 'phage' integrase family
I5818_RS15845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5818_RS15855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_RS15865	COG2257	FlhB HrpN YscU SpaS Family
I5818_RS15875	COG1657	PFAM Prenyltransferase squalene oxidase
I5818_RS15880	COG1979	alcohol dehydrogenase
I5818_RS15890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5818_RS15905	COG0336	Belongs to the RNA methyltransferase TrmD family
I5818_RS15910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5818_RS15920	COG1837	Belongs to the UPF0109 family
I5818_RS15925	COG0228	four-way junction DNA binding
I5818_RS15930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5818_RS15935	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I5818_RS15940	COG0552	protein localization to endoplasmic reticulum
I5818_RS15945	COG1196	nuclear chromosome segregation
I5818_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS15965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5818_RS15970	COG0416	fatty acid biosynthetic process
I5818_RS15980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5818_RS15985	COG1760	l-serine dehydratase
I5818_RS15990	COG1760	l-serine dehydratase
I5818_RS15995	COG1461	Dihydroxyacetone kinase
I5818_RS16000	COG1302	Protein conserved in bacteria
I5818_RS16005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5818_RS16015	COG1564	THIamine pyrophosphokinase
I5818_RS16020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5818_RS16025	COG1162	GTPase activity
I5818_RS16030	COG0515	serine threonine protein kinase
I5818_RS16030	COG2815	serine threonine protein kinase
I5818_RS16035	COG0631	protein serine/threonine phosphatase activity
I5818_RS16040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5818_RS16040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5818_RS16045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5818_RS16050	COG0242	peptide deformylase activity
I5818_RS16055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5818_RS16060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_RS16070	COG0194	GDP metabolic process
I5818_RS16075	COG2052	Domain of unknown function (DUF370)
I5818_RS16080	COG1561	YicC-like family, N-terminal region
I5818_RS16085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I5818_RS16100	COG0284	orotidine-5'-phosphate decarboxylase activity
I5818_RS16105	COG0167	dihydroorotate dehydrogenase activity
I5818_RS16125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_RS16130	COG0540	Belongs to the ATCase OTCase family
I5818_RS16140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5818_RS16145	COG0564	pseudouridine synthase activity
I5818_RS16150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5818_RS16165	COG3599	regulation of cell shape
I5818_RS16170	COG2302	S4 RNA-binding domain
I5818_RS16175	COG0762	integral membrane protein
I5818_RS16180	COG1799	cell septum assembly
I5818_RS16185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5818_RS16190	COG1496	oxidoreductase activity
I5818_RS16195	COG1873	PFAM PRC-barrel domain
I5818_RS16200	COG1191	sigma factor activity
I5818_RS16205	COG1191	sigma factor activity
I5818_RS16215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5818_RS16220	COG0849	cell division
I5818_RS16225	COG3856	small basic protein
I5818_RS16230	COG3879	Bacterial protein of unknown function (DUF881)
I5818_RS16235	COG3879	Bacterial protein of unknown function (DUF881)
I5818_RS16240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5818_RS16245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5818_RS16250	COG0772	Belongs to the SEDS family
I5818_RS16260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_RS16275	COG0768	penicillin binding
I5818_RS16280	COG0768	penicillin binding
I5818_RS16285	COG4839	cell division protein FtsL
I5818_RS16290	COG0275	rRNA processing
I5818_RS16295	COG2001	Belongs to the MraZ family
I5818_RS16300	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I5818_RS16310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_RS16315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5818_RS16325	COG0439	Biotin carboxylase
I5818_RS16330	COG0454	-acetyltransferase
I5818_RS16340	COG1024	Enoyl-CoA hydratase
I5818_RS16345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5818_RS16350	COG1399	metal-binding, possibly nucleic acid-binding protein
I5818_RS16360	COG1323	Belongs to the UPF0348 family
I5818_RS16365	COG3480	Lon protease (S16) C-terminal proteolytic domain
I5818_RS16370	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5818_RS16375	COG3314	Sporulation integral membrane protein YlbJ
I5818_RS16380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5818_RS16385	COG0742	ribosomal rna small subunit methyltransferase
I5818_RS16400	COG4471	UPF0298 protein
I5818_RS16405	COG3679	Belongs to the UPF0342 family
I5818_RS16430	COG2340	Cysteine-rich secretory protein family
I5818_RS16445	COG3336	cytochrome c oxidase
I5818_RS16465	COG2010	Cytochrome c
I5818_RS16465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5818_RS16475	COG1612	heme a metabolic process
I5818_RS16480	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5818_RS16485	COG0772	Belongs to the SEDS family
I5818_RS16500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5818_RS16510	COG4896	Protein conserved in bacteria
I5818_RS16520	COG1217	gtp-binding protein TYPA
I5818_RS16530	COG0483	inositol monophosphate 1-phosphatase activity
I5818_RS16540	COG4493	Belongs to the UPF0637 family
I5818_RS16545	COG4476	Belongs to the UPF0223 family
I5818_RS16555	COG1982	Orn Lys Arg decarboxylase major
I5818_RS16580	COG0022	dehydrogenase e1 component
I5818_RS16595	COG0497	DNA recombination
I5818_RS16605	COG0561	phosphatase activity
I5818_RS16615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5818_RS16620	COG0569	domain protein
I5818_RS16625	COG2197	response regulator
I5818_RS16630	COG4585	Histidine kinase
I5818_RS16635	COG4758	membrane
I5818_RS16650	COG1132	(ABC) transporter
I5818_RS16655	COG1132	(ABC) transporter
I5818_RS16660	COG0668	transmembrane transport
I5818_RS16665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_RS16685	COG0714	Associated with various cellular activities
I5818_RS16700	COG1131	(ABC) transporter
I5818_RS16710	COG1119	ATPase activity
I5818_RS16715	COG1473	amidohydrolase
I5818_RS16720	COG2171	N-acyltransferase activity
I5818_RS16725	COG0583	DNA-binding transcription factor activity
I5818_RS16730	COG1595	DNA-templated transcription, initiation
I5818_RS16740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5818_RS16740	COG2755	lipolytic protein G-D-S-L family
I5818_RS16745	COG0517	IMP dehydrogenase activity
I5818_RS16770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5818_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS16785	COG1408	metallophosphoesterase
I5818_RS16790	COG5001	Diguanylate cyclase
I5818_RS16790	COG3300	MHYT domain
I5818_RS16795	COG1033	growth of symbiont in host cell
I5818_RS16795	COG2409	Drug exporters of the RND superfamily
I5818_RS16800	COG1846	Transcriptional regulator
I5818_RS16810	COG0835	chemotaxis
I5818_RS16810	COG0784	Response regulator, receiver
I5818_RS16815	COG1714	RDD family
I5818_RS16820	COG0436	Aminotransferase
I5818_RS16830	COG2084	Dehydrogenase
I5818_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS16840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5818_RS16860	COG0714	Associated with various cellular activities
I5818_RS16875	COG4873	Protein conserved in bacteria
I5818_RS16885	COG3949	Membrane
I5818_RS16890	COG0542	response to heat
I5818_RS16900	COG1846	Transcriptional regulator
I5818_RS16905	COG3852	Histidine kinase
I5818_RS16915	COG5002	protein histidine kinase activity
I5818_RS16920	COG1032	radical SAM domain protein
I5818_RS16935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5818_RS16950	COG1191	sigma factor activity
I5818_RS16955	COG0861	Integral membrane protein TerC family
I5818_RS16970	COG1757	Na H antiporter
I5818_RS16975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_RS16980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5818_RS17005	COG1363	Peptidase, m42
I5818_RS17010	COG1764	response to oxidative stress
I5818_RS17015	COG4191	Histidine kinase
I5818_RS17025	COG0673	inositol 2-dehydrogenase activity
I5818_RS17040	COG1388	LysM domain
I5818_RS17040	COG4641	Protein conserved in bacteria
I5818_RS17045	COG1388	LysM domain
I5818_RS17045	COG4641	Protein conserved in bacteria
I5818_RS17050	COG0673	inositol 2-dehydrogenase activity
I5818_RS17070	COG1247	-acetyltransferase
I5818_RS17080	COG2382	esterase
I5818_RS17085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5818_RS17090	COG2153	protein acetylation
I5818_RS17095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5818_RS17120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_RS17190	COG0457	Tetratricopeptide repeat
I5818_RS17190	COG0463	Glycosyl transferase, family 2
I5818_RS17200	COG0673	inositol 2-dehydrogenase activity
I5818_RS17235	COG1388	LysM domain
I5818_RS17235	COG4641	Protein conserved in bacteria
I5818_RS17245	COG0475	glutathione-regulated potassium exporter activity
I5818_RS17245	COG0569	domain protein
I5818_RS17255	COG0564	pseudouridine synthase activity
I5818_RS17265	COG2357	RelA SpoT domain protein
I5818_RS17270	COG4116	CYTH
I5818_RS17275	COG0741	lytic transglycosylase activity
I5818_RS17280	COG2346	COG2346, Truncated hemoglobins
I5818_RS17285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5818_RS17290	COG1164	Oligoendopeptidase f
I5818_RS17295	COG4469	Competence protein
I5818_RS17300	COG4862	establishment of competence for transformation
I5818_RS17305	COG1393	Belongs to the ArsC family
I5818_RS17310	COG0456	acetyltransferase
I5818_RS17315	COG0180	Tryptophanyl-tRNA synthetase
I5818_RS17330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS17335	COG0601	transmembrane transport
I5818_RS17345	COG4608	Belongs to the ABC transporter superfamily
I5818_RS17350	COG0444	Belongs to the ABC transporter superfamily
I5818_RS17355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS17360	COG0601	transmembrane transport
I5818_RS17370	COG4608	Belongs to the ABC transporter superfamily
I5818_RS17375	COG0444	Belongs to the ABC transporter superfamily
I5818_RS17380	COG5504	Zn-dependent protease
I5818_RS17385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5818_RS17390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_RS17405	COG1744	ABC transporter substrate-binding protein PnrA-like
I5818_RS17415	COG2267	carboxylic ester hydrolase activity
I5818_RS17425	COG0542	response to heat
I5818_RS17435	COG2151	metal-sulfur cluster biosynthetic enzyme
I5818_RS17440	COG1073	alpha beta
I5818_RS17445	COG0561	phosphatase activity
I5818_RS17460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS17465	COG1307	EDD domain protein, DegV family
I5818_RS17475	COG1666	GTP binding
I5818_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS17490	COG0366	Alpha amylase catalytic
I5818_RS17490	COG1874	Beta-galactosidase
I5818_RS17500	COG5001	Diguanylate cyclase
I5818_RS17500	COG3300	MHYT domain
I5818_RS17510	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5818_RS17515	COG2311	Membrane
I5818_RS17550	COG1074	ATP-dependent DNA helicase activity
I5818_RS17555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I5818_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS17570	COG0398	Pfam SNARE associated Golgi protein
I5818_RS17575	COG0823	Involved in the tonB-independent uptake of proteins
I5818_RS17575	COG1506	peptidase
I5818_RS17575	COG4946	Tricorn protease homolog
I5818_RS17585	COG4903	ComK protein
I5818_RS17595	COG0501	Belongs to the peptidase M48B family
I5818_RS17600	COG2755	lipolytic protein G-D-S-L family
I5818_RS17610	COG1024	Enoyl-CoA hydratase
I5818_RS17615	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_RS17620	COG0095	Lipoate-protein ligase
I5818_RS17625	COG1234	tRNA 3'-trailer cleavage
I5818_RS17635	COG1999	signal sequence binding
I5818_RS17640	COG1511	domain protein
I5818_RS17645	COG1309	transcriptional regulator
I5818_RS17650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5818_RS17655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5818_RS17660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5818_RS17670	COG2197	response regulator
I5818_RS17675	COG4585	Histidine kinase
I5818_RS17685	COG3069	C4-dicarboxylate transmembrane transporter activity
I5818_RS17745	COG1473	amidohydrolase
I5818_RS17755	COG4473	ABC transporter
I5818_RS17760	COG1131	(ABC) transporter
I5818_RS17765	COG0537	adenosine 5'-monophosphoramidase activity
I5818_RS17770	COG4980	gas vesicle protein
I5818_RS17775	COG1846	Transcriptional regulator
I5818_RS17800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5818_RS17810	COG3481	metal-dependent phosphohydrolase, HD sub domain
I5818_RS17815	COG4717	serine-type aminopeptidase activity
I5818_RS17820	COG0420	3'-5' exonuclease activity
I5818_RS17825	COG1668	transmembrane transport
I5818_RS17830	COG4152	abc transporter atp-binding protein
I5818_RS17835	COG0861	Integral membrane protein TerC family
I5818_RS17845	COG1024	Enoyl-CoA hydratase
I5818_RS17850	COG2910	NAD(P)H-binding
I5818_RS17855	COG1959	2 iron, 2 sulfur cluster binding
I5818_RS17860	COG0561	phosphatase activity
I5818_RS17875	COG0189	ligase activity
I5818_RS17880	COG0189	ligase activity
I5818_RS17900	COG2508	Transcriptional regulator
I5818_RS17905	COG3842	ATPase activity
I5818_RS17930	COG2814	Major facilitator Superfamily
I5818_RS17935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_RS17940	COG3852	Histidine kinase
I5818_RS17960	COG0659	secondary active sulfate transmembrane transporter activity
I5818_RS17965	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS17975	COG4608	Belongs to the ABC transporter superfamily
I5818_RS17980	COG0444	Belongs to the ABC transporter superfamily
I5818_RS17985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS17990	COG0601	transmembrane transport
I5818_RS17995	COG4166	transmembrane transport
I5818_RS18010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5818_RS18015	COG0598	Magnesium transport protein CorA
I5818_RS18025	COG1280	lysine exporter protein (LysE YggA)
I5818_RS18070	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_RS18075	COG2271	Major facilitator Superfamily
I5818_RS18080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5818_RS18085	COG2267	carboxylic ester hydrolase activity
I5818_RS18095	COG1253	flavin adenine dinucleotide binding
I5818_RS18105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5818_RS18130	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS18170	COG4191	Histidine kinase
I5818_RS18180	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_RS18230	COG1122	ATPase activity
I5818_RS18235	COG1122	ATPase activity
I5818_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS18270	COG0789	Transcriptional regulator
I5818_RS18290	COG0477	Major facilitator Superfamily
I5818_RS18325	COG2719	SpoVR family
I5818_RS18360	COG0564	pseudouridine synthase activity
I5818_RS18375	COG1960	acyl-CoA dehydrogenase activity
I5818_RS18380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5818_RS18385	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_RS18390	COG1392	Phosphate transport regulator
I5818_RS18395	COG0306	phosphate transporter
I5818_RS18410	COG2252	PERMEase
I5818_RS18420	COG2814	Major facilitator Superfamily
I5818_RS18430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5818_RS18435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_RS18440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5818_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS18475	COG2409	Drug exporters of the RND superfamily
I5818_RS18480	COG2197	response regulator
I5818_RS18485	COG4585	Histidine kinase
I5818_RS18495	COG1687	branched-chain amino acid
I5818_RS18500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5818_RS18505	COG1522	sequence-specific DNA binding
I5818_RS18515	COG2124	cytochrome p450
I5818_RS18565	COG0587	DNA-directed DNA polymerase activity
I5818_RS18590	COG1309	transcriptional regulator
I5818_RS18605	COG2814	Major facilitator Superfamily
I5818_RS18610	COG0583	DNA-binding transcription factor activity
I5818_RS18620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5818_RS18650	COG0346	lactoylglutathione lyase activity
I5818_RS18655	COG1683	Conserved Protein
I5818_RS18670	COG1309	transcriptional regulator
I5818_RS18690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_RS18705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5818_RS18715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_RS18725	COG1136	(ABC) transporter
I5818_RS18745	COG0022	dehydrogenase e1 component
I5818_RS18755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_RS18765	COG1122	ATPase activity
I5818_RS18785	COG3327	negative regulation of DNA-templated transcription, initiation
I5818_RS18790	COG0183	Belongs to the thiolase family
I5818_RS18795	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_RS18800	COG1024	Enoyl-CoA hydratase
I5818_RS18815	COG2151	metal-sulfur cluster biosynthetic enzyme
I5818_RS18830	COG3396	Phenylacetate-CoA oxygenase
I5818_RS18835	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5818_RS18840	COG3104	oligopeptide transport
I5818_RS18865	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5818_RS18880	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS18885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5818_RS18890	COG0583	DNA-binding transcription factor activity
I5818_RS18895	COG2814	Major facilitator Superfamily
I5818_RS18900	COG0726	polysaccharide deacetylase
I5818_RS18905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5818_RS18910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_RS18910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_RS18915	COG0307	riboflavin synthase, alpha
I5818_RS18920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5818_RS18920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5818_RS18925	COG0753	catalase activity
I5818_RS18955	COG2718	Belongs to the UPF0229 family
I5818_RS18960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS18975	COG2766	serine protein kinase
I5818_RS18980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5818_RS18995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5818_RS19005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_RS19005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_RS19015	COG1595	DNA-templated transcription, initiation
I5818_RS19040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5818_RS19045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_RS19050	COG1131	(ABC) transporter
I5818_RS19055	COG2755	lipolytic protein G-D-S-L family
I5818_RS19085	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS19095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5818_RS19100	COG2814	Major facilitator Superfamily
I5818_RS19110	COG1476	TRANSCRIPTIONal
I5818_RS19120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_RS19160	COG0402	S-adenosylhomocysteine deaminase activity
I5818_RS19165	COG0402	S-adenosylhomocysteine deaminase activity
I5818_RS19170	COG0590	tRNA wobble adenosine to inosine editing
I5818_RS19180	COG0583	DNA-binding transcription factor activity
I5818_RS19190	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_RS19215	COG3264	Mechanosensitive ion channel
I5818_RS19215	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I5818_RS19250	COG4187	Peptidase family M20/M25/M40
I5818_RS19280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5818_RS19285	COG2304	oxidoreductase activity
I5818_RS19315	COG1309	transcriptional regulator
I5818_RS19320	COG2814	Major facilitator Superfamily
I5818_RS19325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS19340	COG0305	Participates in initiation and elongation during chromosome replication
I5818_RS19350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5818_RS19370	COG0288	reversible hydration of carbon dioxide
I5818_RS19375	COG3002	Belongs to the UPF0753 family
I5818_RS19380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5818_RS19385	COG5609	conserved protein (DUF2294)
I5818_RS19455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_RS19460	COG2030	dehydratase
I5818_RS19480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_RS19495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_RS19685	COG0735	belongs to the Fur family
I5818_RS19690	COG2096	Adenosyltransferase
I5818_RS19700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5818_RS19710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5818_RS19715	COG4129	membrane
I5818_RS19720	COG1132	(ABC) transporter
I5818_RS19725	COG3557	Belongs to the UPF0374 family
I5818_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS19755	COG0583	DNA-binding transcription factor activity
I5818_RS19760	COG0069	glutamate synthase activity
I5818_RS19760	COG0070	glutamate synthase
I5818_RS19760	COG0067	glutamate synthase
I5818_RS19765	COG0493	'glutamate synthase
I5818_RS19770	COG1194	a g-specific adenine glycosylase
I5818_RS19775	COG1988	membrane-bound metal-dependent
I5818_RS19795	COG2137	regulation of response to DNA damage stimulus
I5818_RS19820	COG0159	tryptophan synthase activity
I5818_RS19840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5818_RS19840	COG0512	Glutamine amidotransferase of anthranilate synthase
I5818_RS19845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5818_RS19860	COG0673	inositol 2-dehydrogenase activity
I5818_RS19870	COG3833	ABC-type maltose transport systems, permease component
I5818_RS19875	COG1175	transmembrane transport
I5818_RS19880	COG2182	Extracellular solute-binding protein
I5818_RS19895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_RS19900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5818_RS19910	COG5416	Lipopolysaccharide assembly protein A domain
I5818_RS19925	COG0066	3-isopropylmalate dehydratase activity
I5818_RS19930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5818_RS19940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5818_RS19945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5818_RS19950	COG0440	acetolactate synthase activity
I5818_RS19955	COG0028	Belongs to the TPP enzyme family
I5818_RS19960	COG0129	dihydroxy-acid dehydratase activity
I5818_RS19970	COG0460	homoserine dehydrogenase
I5818_RS19975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5818_RS19980	COG0083	homoserine kinase activity
I5818_RS19990	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS19995	COG0028	Belongs to the TPP enzyme family
I5818_RS20000	COG0069	glutamate synthase activity
I5818_RS20030	COG2723	6-phospho-beta-galactosidase activity
I5818_RS20035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS20035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS20040	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_RS20050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS20060	COG2814	Major facilitator Superfamily
I5818_RS20065	COG0640	Transcriptional regulator
I5818_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS20080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_RS20105	COG1725	Transcriptional regulator
I5818_RS20115	COG1917	Cupin 2, conserved barrel domain protein
I5818_RS20115	COG2207	Transcriptional regulator
I5818_RS20120	COG0697	spore germination
I5818_RS20130	COG1819	glycosyl
I5818_RS20135	COG0124	histidyl-tRNA synthetase
I5818_RS20160	COG0561	phosphatase activity
I5818_RS20170	COG1940	carbohydrate kinase activity
I5818_RS20175	COG2207	Transcriptional regulator
I5818_RS20175	COG3708	Transcriptional regulator
I5818_RS20190	COG0475	glutathione-regulated potassium exporter activity
I5818_RS20205	COG0640	Transcriptional regulator
I5818_RS20215	COG2890	protein-(glutamine-N5) methyltransferase activity
I5818_RS20255	COG0583	DNA-binding transcription factor activity
I5818_RS20260	COG1942	4-Oxalocrotonate Tautomerase
I5818_RS20265	COG2070	2-Nitropropane dioxygenase
I5818_RS20270	COG1846	Transcriptional regulator
I5818_RS20275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS20295	COG0640	Transcriptional regulator
I5818_RS20315	COG1522	sequence-specific DNA binding
I5818_RS20350	COG2871	sodium ion transport
I5818_RS20355	COG5646	InterPro IPR014922
I5818_RS20365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS20375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS20380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_RS20390	COG0384	phenazine biosynthesis protein PhzF
I5818_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS20415	COG0604	alcohol dehydrogenase
I5818_RS20420	COG0640	Transcriptional regulator
I5818_RS20425	COG1335	isochorismatase
I5818_RS20440	COG0789	Transcriptional regulator
I5818_RS20455	COG3963	phosphatidate phosphatase activity
I5818_RS20465	COG2318	DinB family
I5818_RS20470	COG2378	regulation of single-species biofilm formation
I5818_RS20490	COG1279	arginine transmembrane transporter activity
I5818_RS20495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_RS20505	COG1288	antiporter activity
I5818_RS20510	COG3279	Response regulator of the LytR AlgR family
I5818_RS20515	COG3275	phosphorelay sensor kinase activity
I5818_RS20520	COG0662	Cupin 2, conserved barrel domain protein
I5818_RS20550	COG1017	nitric oxide dioxygenase activity
I5818_RS20550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5818_RS20555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5818_RS20560	COG0583	DNA-binding transcription factor activity
I5818_RS20570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS20575	COG2072	flavoprotein involved in K transport
I5818_RS20585	COG0561	phosphatase activity
I5818_RS20590	COG1609	Transcriptional regulator
I5818_RS20600	COG0346	lactoylglutathione lyase activity
I5818_RS20605	COG0640	Transcriptional regulator
I5818_RS20620	COG0702	epimerase
I5818_RS20625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5818_RS20640	COG1278	Cold shock
I5818_RS20645	COG0456	acetyltransferase
I5818_RS20650	COG1846	Transcriptional regulator
I5818_RS20670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_RS20685	COG2318	DinB family
I5818_RS20690	COG1595	DNA-templated transcription, initiation
I5818_RS20705	COG0488	(ABC) transporter
I5818_RS20730	COG0667	Aldo Keto reductase
I5818_RS20740	COG1309	transcriptional regulator
I5818_RS20780	COG0574	Belongs to the PEP-utilizing enzyme family
I5818_RS20780	COG3848	Pyruvate phosphate dikinase
I5818_RS20785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5818_RS20790	COG3546	catalase activity
I5818_RS20820	COG2378	regulation of single-species biofilm formation
I5818_RS20850	COG0500	methyltransferase
I5818_RS20865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5818_RS20890	COG1051	belongs to the nudix hydrolase family
I5818_RS20910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5818_RS20925	COG0583	DNA-binding transcription factor activity
I5818_RS20945	COG3739	integral membrane protein
I5818_RS20950	COG3655	Transcriptional regulator
I5818_RS20970	COG1404	Belongs to the peptidase S8 family
I5818_RS20985	COG2814	Major facilitator Superfamily
I5818_RS20990	COG0789	Transcriptional regulator
I5818_RS20995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_RS21000	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5818_RS21025	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I5818_RS21030	COG1492	cobalamin metabolic process
I5818_RS21040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_RS21045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I5818_RS21050	COG1120	ATPase activity
I5818_RS21055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS21060	COG2096	Adenosyltransferase
I5818_RS21065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS21070	COG0733	neurotransmitter:sodium symporter activity
I5818_RS21075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_RS21075	COG1605	Chorismate mutase
I5818_RS21080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5818_RS21085	COG0095	Lipoate-protein ligase
I5818_RS21090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5818_RS21095	COG1051	belongs to the nudix hydrolase family
I5818_RS21100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_RS21115	COG0583	DNA-binding transcription factor activity
I5818_RS21120	COG1607	acyl-coa hydrolase
I5818_RS21155	COG4895	conserved protein (DUF2196)
I5818_RS21160	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS21170	COG3243	poly(R)-hydroxyalkanoic acid synthase
I5818_RS21175	COG0745	RESPONSE REGULATOR receiver
I5818_RS21200	COG0477	Major facilitator Superfamily
I5818_RS21215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5818_RS21225	COG0686	Belongs to the AlaDH PNT family
I5818_RS21230	COG2508	Transcriptional regulator
I5818_RS21230	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5818_RS21235	COG1113	amino acid transport
I5818_RS21240	COG0778	Nitroreductase
I5818_RS21245	COG1733	regulation of RNA biosynthetic process
I5818_RS21250	COG1115	amino acid carrier protein
I5818_RS21260	COG0517	IMP dehydrogenase activity
I5818_RS21260	COG0516	GMP reductase activity
I5818_RS21270	COG2346	COG2346, Truncated hemoglobins
I5818_RS21275	COG3706	GGDEF domain
I5818_RS21280	COG0840	transmembrane signaling receptor activity
I5818_RS21285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_RS21305	COG0840	transmembrane signaling receptor activity
I5818_RS21330	COG1566	PFAM secretion protein HlyD family protein
I5818_RS21345	COG4608	Belongs to the ABC transporter superfamily
I5818_RS21350	COG0444	Belongs to the ABC transporter superfamily
I5818_RS21355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS21360	COG0601	transmembrane transport
I5818_RS21365	COG4166	transmembrane transport
I5818_RS21375	COG2205	protein histidine kinase activity
I5818_RS21385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_RS21390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_RS21420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5818_RS21425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5818_RS21430	COG2169	Transcriptional regulator
I5818_RS21450	COG0535	radical SAM domain protein
I5818_RS21465	COG0387	Pfam Sodium calcium exchanger
I5818_RS21470	COG0477	Major facilitator Superfamily
I5818_RS21475	COG2217	Heavy metal translocating P-type atpase
I5818_RS21485	COG1295	ribonuclease BN
I5818_RS21490	COG4840	Belongs to the UPF0435 family
I5818_RS21500	COG0024	Methionine aminopeptidase
I5818_RS21505	COG1360	Flagellar Motor Protein
I5818_RS21510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5818_RS21530	COG1959	2 iron, 2 sulfur cluster binding
I5818_RS21540	COG2309	aminopeptidase activity
I5818_RS21545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5818_RS21550	COG2986	histidine ammonia-lyase
I5818_RS21555	COG1607	acyl-coa hydrolase
I5818_RS21560	COG0701	Predicted permease
I5818_RS21565	COG3689	TIGRFAM TIGR03943 family protein
I5818_RS21570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS21575	COG1077	Cell shape determining protein MreB Mrl
I5818_RS21580	COG2268	Band 7 protein
I5818_RS21585	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5818_RS21590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5818_RS21605	COG0626	cystathionine gamma-synthase activity
I5818_RS21610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_RS21615	COG1854	S-ribosylhomocysteine lyase activity
I5818_RS21625	COG0288	reversible hydration of carbon dioxide
I5818_RS21640	COG5002	protein histidine kinase activity
I5818_RS21660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5818_RS21660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5818_RS21660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS21670	COG2376	Dihydroxyacetone kinase
I5818_RS21675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5818_RS21680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5818_RS21685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_RS21695	COG1252	NADH dehydrogenase
I5818_RS21790	COG3299	homolog of phage Mu protein gp47
I5818_RS21905	COG5484	DNA packaging
I5818_RS21905	COG3728	DNA packaging
I5818_RS21920	COG3677	Transposase
I5818_RS22070	COG1396	sequence-specific DNA binding
I5818_RS22075	COG2856	Zn peptidase
I5818_RS22105	COG0582	viral genome integration into host DNA
I5818_RS22120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS22130	COG0285	dihydrofolate synthase activity
I5818_RS22135	COG3706	GGDEF domain
I5818_RS22140	COG1414	Transcriptional regulator
I5818_RS22150	COG1012	belongs to the aldehyde dehydrogenase family
I5818_RS22155	COG0028	Belongs to the TPP enzyme family
I5818_RS22160	COG0436	Aminotransferase
I5818_RS22165	COG1757	Na H antiporter
I5818_RS22175	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_RS22180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS22185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_RS22190	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5818_RS22190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5818_RS22195	COG2244	polysaccharide biosynthetic process
I5818_RS22200	COG1268	BioY protein
I5818_RS22205	COG0024	Methionine aminopeptidase
I5818_RS22225	COG0488	(ABC) transporter
I5818_RS22245	COG0513	Belongs to the DEAD box helicase family
I5818_RS22265	COG2205	protein histidine kinase activity
I5818_RS22270	COG3973	AAA domain
I5818_RS22275	COG1278	Cold shock
I5818_RS22280	COG0604	alcohol dehydrogenase
I5818_RS22280	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS22280	COG3321	synthase
I5818_RS22300	COG1388	LysM domain
I5818_RS22300	COG3584	3D domain protein
I5818_RS22315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_RS22315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_RS22330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5818_RS22345	COG2205	protein histidine kinase activity
I5818_RS22350	COG0527	aspartate kinase activity
I5818_RS22365	COG0166	Belongs to the GPI family
I5818_RS22370	COG1132	(ABC) transporter
I5818_RS22375	COG1132	(ABC) transporter
I5818_RS22380	COG0406	alpha-ribazole phosphatase activity
I5818_RS22385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5818_RS22390	COG3340	Belongs to the peptidase S51 family
I5818_RS22395	COG2309	aminopeptidase activity
I5818_RS22405	COG1131	(ABC) transporter
I5818_RS22420	COG3695	enzyme binding
I5818_RS22430	COG2814	Major facilitator Superfamily
I5818_RS22435	COG1846	Transcriptional regulator
I5818_RS22440	COG0534	Mate efflux family protein
I5818_RS22445	COG0210	DNA helicase
I5818_RS22455	COG0697	spore germination
I5818_RS22465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_RS22480	COG1404	Belongs to the peptidase S8 family
I5818_RS22485	COG2132	Multicopper oxidase
I5818_RS22490	COG1966	Carbon starvation protein
I5818_RS22500	COG0390	transport system, permease component
I5818_RS22505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_RS22515	COG2706	6-phosphogluconolactonase activity
I5818_RS22525	COG0589	response to stress
I5818_RS22545	COG2197	response regulator
I5818_RS22550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5818_RS22555	COG3447	MASE1 domain protein
I5818_RS22555	COG5001	Diguanylate cyclase
I5818_RS22555	COG5002	protein histidine kinase activity
I5818_RS22560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_RS22565	COG1126	abc transporter atp-binding protein
I5818_RS22570	COG0765	amino acid transport
I5818_RS22575	COG0765	amino acid transport
I5818_RS22580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS22585	COG5001	Diguanylate cyclase
I5818_RS22585	COG3300	MHYT domain
I5818_RS22595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5818_RS22600	COG1525	nuclease
I5818_RS22605	COG1525	nuclease
I5818_RS22610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5818_RS22615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_RS22625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_RS22630	COG3716	PTS system mannose fructose sorbose family IID component
I5818_RS22635	COG3715	PTS system
I5818_RS22650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5818_RS22650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5818_RS22655	COG0025	NhaP-type Na H and K H
I5818_RS22670	COG0246	Mannitol dehydrogenase
I5818_RS22675	COG3711	transcriptional antiterminator
I5818_RS22680	COG2213	PTS system mannitol-specific
I5818_RS22680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS22685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_RS22690	COG4948	Mandelate Racemase Muconate Lactonizing
I5818_RS22705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I5818_RS22725	COG5002	protein histidine kinase activity
I5818_RS22740	COG0789	Transcriptional regulator
I5818_RS22745	COG0494	nUDIX hydrolase
I5818_RS22750	COG0406	alpha-ribazole phosphatase activity
I5818_RS22755	COG2259	Doxx family
I5818_RS22760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS22760	COG1263	PTS System
I5818_RS22765	COG3711	transcriptional antiterminator
I5818_RS22770	COG2190	(PTS) system
I5818_RS22785	COG0300	oxidoreductase activity
I5818_RS22800	COG2814	Major facilitator Superfamily
I5818_RS22945	COG0506	proline dehydrogenase activity
I5818_RS22960	COG3279	Response regulator of the LytR AlgR family
I5818_RS22965	COG2972	Histidine kinase
I5818_RS22965	COG0745	RESPONSE REGULATOR receiver
I5818_RS22970	COG3279	Response regulator of the LytR AlgR family
I5818_RS22985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5818_RS23010	COG1940	carbohydrate kinase activity
I5818_RS23015	COG2723	6-phospho-beta-galactosidase activity
I5818_RS23020	COG1482	cell wall glycoprotein biosynthetic process
I5818_RS23045	COG1131	(ABC) transporter
I5818_RS23055	COG4260	virion core protein, lumpy skin disease virus
I5818_RS23060	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5818_RS23065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5818_RS23070	COG1842	Phage shock protein A
I5818_RS23080	COG1595	DNA-templated transcription, initiation
I5818_RS23090	COG0604	alcohol dehydrogenase
I5818_RS23100	COG1757	Na H antiporter
I5818_RS23105	COG0400	carboxylic ester hydrolase activity
I5818_RS23110	COG0346	lactoylglutathione lyase activity
I5818_RS23115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_RS23125	COG1027	Aspartate ammonia-lyase
I5818_RS23135	COG2309	aminopeptidase activity
I5818_RS23140	COG0145	ligase activity
I5818_RS23150	COG1953	Uracil, thiamine, allantoin
I5818_RS23155	COG2508	Transcriptional regulator
I5818_RS23165	COG2814	Major facilitator Superfamily
I5818_RS23170	COG1785	Belongs to the alkaline phosphatase family
I5818_RS23185	COG1126	abc transporter atp-binding protein
I5818_RS23190	COG0765	amino acid transport
I5818_RS23195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS23205	COG1876	peptidase activity
I5818_RS23210	COG2409	Drug exporters of the RND superfamily
I5818_RS23210	COG1033	growth of symbiont in host cell
I5818_RS23215	COG1846	Transcriptional regulator
I5818_RS23225	COG0583	DNA-binding transcription factor activity
I5818_RS23245	COG4807	Protein conserved in bacteria
I5818_RS23255	COG4555	ABC transporter
I5818_RS23300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_RS23330	COG4824	toxin secretion phage lysis holin
I5818_RS23400	COG0740	serine-type endopeptidase activity
I5818_RS23405	COG4695	Portal protein
I5818_RS23410	COG1802	Transcriptional regulator
I5818_RS23410	COG4626	Terminase
I5818_RS23440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5818_RS23490	COG3561	AntA/AntB antirepressor
I5818_RS23505	COG3226	Transcriptional regulator
I5818_RS23510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_RS23510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_RS23545	COG1401	restriction endodeoxyribonuclease activity
I5818_RS23570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5818_RS23575	COG0789	Transcriptional regulator
I5818_RS23595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS23605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_RS23620	COG1597	lipid kinase activity
I5818_RS23640	COG1309	transcriptional regulator
I5818_RS23645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS23650	COG2404	hydrolase activity, acting on ester bonds
I5818_RS23655	COG0400	carboxylic ester hydrolase activity
I5818_RS23660	COG0346	lactoylglutathione lyase activity
I5818_RS23665	COG0840	transmembrane signaling receptor activity
I5818_RS23680	COG0154	amidase activity
I5818_RS23685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5818_RS23690	COG2224	Isocitrate lyase
I5818_RS23695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5818_RS23700	COG4851	CamS sex pheromone cAM373 precursor
I5818_RS23705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5818_RS23710	COG0210	DNA helicase
I5818_RS23715	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I5818_RS23730	COG4496	protein, YerC YecD
I5818_RS23735	COG1470	cell adhesion involved in biofilm formation
I5818_RS23750	COG0151	Belongs to the GarS family
I5818_RS23760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5818_RS23765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5818_RS23770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5818_RS23785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5818_RS23790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I5818_RS23795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5818_RS23800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5818_RS23805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5818_RS23815	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I5818_RS23835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS23835	COG1263	PTS System
I5818_RS23835	COG2190	(PTS) system
I5818_RS23840	COG3711	transcriptional antiterminator
I5818_RS23845	COG2252	PERMEase
I5818_RS23860	COG0519	Catalyzes the synthesis of GMP from XMP
I5818_RS23860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5818_RS23865	COG1305	Transglutaminase-like
I5818_RS23870	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I5818_RS23875	COG0714	Associated with various cellular activities
I5818_RS23885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5818_RS23890	COG1335	isochorismatase
I5818_RS23895	COG0833	amino acid
I5818_RS23900	COG2304	oxidoreductase activity
I5818_RS23935	COG2304	oxidoreductase activity
I5818_RS23975	COG2814	Major facilitator Superfamily
I5818_RS24010	COG1266	CAAX protease self-immunity
I5818_RS24020	COG0805	protein transport
I5818_RS24025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_RS24030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I5818_RS24035	COG0315	cyclic pyranopterin monophosphate synthase activity
I5818_RS24040	COG0488	(ABC) transporter
I5818_RS24050	COG0456	acetyltransferase
I5818_RS24055	COG1214	PFAM Peptidase M22, glycoprotease
I5818_RS24060	COG0802	atpase or kinase
I5818_RS24140	COG3091	SprT-like family
I5818_RS24150	COG2183	response to ionizing radiation
I5818_RS24155	COG2208	phosphoserine phosphatase activity
I5818_RS24160	COG1191	sigma factor activity
I5818_RS24165	COG2172	sigma factor antagonist activity
I5818_RS24170	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_RS24175	COG2208	phosphoserine phosphatase activity
I5818_RS24180	COG2172	sigma factor antagonist activity
I5818_RS24185	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_RS24190	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_RS24195	COG2337	Toxic component of a toxin-antitoxin (TA) module
I5818_RS24200	COG0864	Transcriptional regulator
I5818_RS24210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5818_RS24215	COG0736	holo-[acyl-carrier-protein] synthase activity
I5818_RS24220	COG0705	Rhomboid family
I5818_RS24225	COG3428	Bacterial PH domain
I5818_RS24230	COG3402	PFAM membrane-flanked domain
I5818_RS24235	COG0513	Belongs to the DEAD box helicase family
I5818_RS24240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5818_RS24245	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5818_RS24255	COG1253	flavin adenine dinucleotide binding
I5818_RS24260	COG0772	Belongs to the SEDS family
I5818_RS24265	COG0789	Transcriptional regulator
I5818_RS24270	COG1253	flavin adenine dinucleotide binding
I5818_RS24275	COG0018	arginyl-trna synthetase
I5818_RS24285	COG4555	ABC transporter
I5818_RS24295	COG2814	Major facilitator Superfamily
I5818_RS24300	COG1664	Polymer-forming cytoskeletal
I5818_RS24305	COG1664	Polymer-forming cytoskeletal
I5818_RS24310	COG0789	Transcriptional regulator
I5818_RS24315	COG2070	2-Nitropropane dioxygenase
I5818_RS24330	COG1785	Belongs to the alkaline phosphatase family
I5818_RS24335	COG4715	Zinc finger, swim domain protein
I5818_RS24340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_RS24350	COG0629	single-stranded DNA binding
I5818_RS24370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5818_RS24380	COG4786	Flagellar basal body rod
I5818_RS24385	COG4786	Flagellar basal body rod
I5818_RS24390	COG1077	Cell shape determining protein MreB Mrl
I5818_RS24395	COG1609	Transcriptional regulator
I5818_RS24400	COG0739	heme binding
I5818_RS24405	COG2385	sporulation resulting in formation of a cellular spore
I5818_RS24410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5818_RS24420	COG4836	Membrane
I5818_RS24425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5818_RS24430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5818_RS24435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5818_RS24440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5818_RS24445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5818_RS24450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5818_RS24455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5818_RS24460	COG0356	it plays a direct role in the translocation of protons across the membrane
I5818_RS24470	COG1404	Belongs to the peptidase S8 family
I5818_RS24475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5818_RS24480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5818_RS24495	COG0698	ribose 5-phosphate isomerase
I5818_RS24505	COG2814	Major facilitator Superfamily
I5818_RS24510	COG0840	transmembrane signaling receptor activity
I5818_RS24520	COG1971	Probably functions as a manganese efflux pump
I5818_RS24525	COG0009	L-threonylcarbamoyladenylate synthase
I5818_RS24550	COG0156	8-amino-7-oxononanoate synthase activity
I5818_RS24555	COG1435	thymidine kinase activity
I5818_RS24565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5818_RS24570	COG1494	fructose-1,6-bisphosphatase
I5818_RS24575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5818_RS24580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5818_RS24585	COG0191	fructose-bisphosphate aldolase activity
I5818_RS24590	COG2204	response regulator
I5818_RS24605	COG0504	CTP synthase activity
I5818_RS24615	COG1703	isobutyryl-CoA mutase activity
I5818_RS24615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_RS24615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_RS24625	COG1960	acyl-CoA dehydrogenase activity
I5818_RS24630	COG1960	acyl-CoA dehydrogenase activity
I5818_RS24635	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_RS24640	COG0183	Belongs to the thiolase family
I5818_RS24645	COG0247	lactate metabolic process
I5818_RS24645	COG2181	nitrate reductase activity
I5818_RS24650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5818_RS24655	COG0018	arginyl-trna synthetase
I5818_RS24665	COG0730	response to heat
I5818_RS24670	COG0010	Belongs to the arginase family
I5818_RS24675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5818_RS24680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_RS24690	COG1994	Peptidase M50
I5818_RS24700	COG3465	dGTPase activity
I5818_RS24705	COG1078	dGTPase activity
I5818_RS24715	COG1132	(ABC) transporter
I5818_RS24720	COG1132	(ABC) transporter
I5818_RS24730	COG0280	phosphate acetyltransferase
I5818_RS24735	COG3253	May function as heme-dependent peroxidase
I5818_RS24745	COG2363	Small membrane protein
I5818_RS24760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5818_RS24770	COG0314	molybdopterin synthase activity
I5818_RS24775	COG0746	molybdenum cofactor guanylyltransferase activity
I5818_RS24780	COG0346	lactoylglutathione lyase activity
I5818_RS24800	COG0840	transmembrane signaling receptor activity
I5818_RS24805	COG2205	protein histidine kinase activity
I5818_RS24810	COG0745	RESPONSE REGULATOR receiver
I5818_RS24820	COG0351	phosphomethylpyrimidine kinase
I5818_RS24825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5818_RS24850	COG1309	transcriptional regulator
I5818_RS24855	COG0561	phosphatase activity
I5818_RS24860	COG2031	fatty acid transporter
I5818_RS24865	COG0514	ATP-dependent DNA helicase (RecQ)
I5818_RS24875	COG0156	8-amino-7-oxononanoate synthase activity
I5818_RS24880	COG1737	Transcriptional regulator
I5818_RS24885	COG0456	acetyltransferase
I5818_RS24885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_RS24890	COG3876	Protein conserved in bacteria
I5818_RS24900	COG3842	ATPase activity
I5818_RS24905	COG0395	ABC-type sugar transport system, permease component
I5818_RS24910	COG1175	transmembrane transport
I5818_RS24920	COG1472	Belongs to the glycosyl hydrolase 3 family
I5818_RS24930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_RS24935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I5818_RS24940	COG0456	acetyltransferase
I5818_RS24950	COG0395	ABC-type sugar transport system, permease component
I5818_RS24955	COG1175	transmembrane transport
I5818_RS24960	COG1653	transport
I5818_RS24965	COG1649	PFAM Uncharacterised BCR, COG1649
I5818_RS24975	COG2971	BadF BadG BcrA BcrD
I5818_RS24985	COG1263	PTS System
I5818_RS24985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_RS24995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_RS25010	COG1247	-acetyltransferase
I5818_RS25015	COG3279	Response regulator of the LytR AlgR family
I5818_RS25020	COG0427	acetyl-CoA hydrolase
I5818_RS25025	COG1823	symporter activity
I5818_RS25035	COG0737	Belongs to the 5'-nucleotidase family
I5818_RS25040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_RS25045	COG3639	organic phosphonate transmembrane transporter activity
I5818_RS25055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5818_RS25065	COG0367	asparagine synthase
I5818_RS25080	COG2966	Psort location CytoplasmicMembrane, score
I5818_RS25090	COG4607	ABC-type enterochelin transport system periplasmic component
I5818_RS25095	COG4604	ABC transporter, ATP-binding protein
I5818_RS25100	COG4605	iron ion homeostasis
I5818_RS25105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_RS25115	COG1126	abc transporter atp-binding protein
I5818_RS25120	COG0765	amino acid transport
I5818_RS25130	COG0488	(ABC) transporter
I5818_RS25135	COG0531	amino acid
I5818_RS25145	COG0840	transmembrane signaling receptor activity
I5818_RS25150	COG0492	ferredoxin-NADP+ reductase activity
I5818_RS25160	COG1301	dicarboxylic acid transport
I5818_RS25170	COG1132	(ABC) transporter
I5818_RS25180	COG2080	2 iron, 2 sulfur cluster binding
I5818_RS25195	COG2068	MobA-Related Protein
I5818_RS25200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5818_RS25210	COG0444	Belongs to the ABC transporter superfamily
I5818_RS25215	COG4608	Belongs to the ABC transporter superfamily
I5818_RS25225	COG0601	transmembrane transport
I5818_RS25230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_RS25240	COG2259	Doxx family
I5818_RS25255	COG5002	protein histidine kinase activity
I5818_RS25265	COG0667	Aldo Keto reductase
I5818_RS25270	COG0534	Mate efflux family protein
I5818_RS25275	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5818_RS25290	COG3844	kynureninase activity
I5818_RS25300	COG3104	oligopeptide transport
I5818_RS25325	COG0805	protein transport
I5818_RS25340	COG1309	transcriptional regulator
I5818_RS25345	COG2357	RelA SpoT domain protein
I5818_RS25360	COG0402	S-adenosylhomocysteine deaminase activity
I5818_RS25365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_RS25370	COG0583	DNA-binding transcription factor activity
I5818_RS25385	COG1301	dicarboxylic acid transport
I5818_RS25390	COG4565	transcriptional regulatory protein
I5818_RS25395	COG3290	protein histidine kinase activity
I5818_RS25400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5818_RS25405	COG1113	amino acid transport
I5818_RS25420	COG1725	Transcriptional regulator
I5818_RS25430	COG2205	protein histidine kinase activity
I5818_RS25435	COG0745	RESPONSE REGULATOR receiver
I5818_RS25445	COG0577	efflux transmembrane transporter activity
I5818_RS25450	COG1136	(ABC) transporter
I5818_RS25465	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_RS25475	COG0450	alkyl hydroperoxide reductase
I5818_RS25485	COG1482	cell wall glycoprotein biosynthetic process
I5818_RS25490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS25490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS25490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_RS25495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_RS25495	COG3711	transcriptional antiterminator
I5818_RS25505	COG2233	PERMEase
I5818_RS25520	COG0765	amino acid transport
I5818_RS25545	COG1846	Transcriptional regulator
I5818_RS25555	COG0579	oxidoreductase
I5818_RS25560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5818_RS25595	COG1349	DNA-binding transcription factor activity
I5818_RS25625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_RS25665	COG0789	Transcriptional regulator
I5818_RS25695	COG2207	Transcriptional regulator
I5818_RS25705	COG2814	Major facilitator Superfamily
I5818_RS25710	COG4221	oxidoreductase activity
I5818_RS25715	COG1846	Transcriptional regulator
I5818_RS25720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_RS25740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5818_RS25745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5818_RS25750	COG4853	Protein conserved in bacteria
I5818_RS25760	COG5002	protein histidine kinase activity
I5818_RS25765	COG0745	RESPONSE REGULATOR receiver
I5818_RS25770	COG1388	LysM domain
I5818_RS25770	COG4942	peptidase
I5818_RS25790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5818_RS25795	COG0305	Participates in initiation and elongation during chromosome replication
I5818_RS25800	COG0359	binds to the 23S rRNA
I5818_RS25805	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I5818_RS25810	COG4241	membrane
I5818_RS25815	COG0840	transmembrane signaling receptor activity
I5818_RS25820	COG1595	DNA-templated transcription, initiation
I5818_RS25830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5818_RS25840	COG0360	Binds together with S18 to 16S ribosomal RNA
I5818_RS25845	COG0012	GTP binding
I5818_RS25850	COG4481	Protein conserved in bacteria
I5818_RS25855	COG0668	transmembrane transport
I5818_RS25870	COG1475	DNA binding
I5818_RS25875	COG1192	Involved in chromosome partitioning
I5818_RS25880	COG1475	DNA binding
I5818_RS25885	COG0357	Ribosomal RNA small subunit methyltransferase G
I5818_RS25890	COG0445	tRNA wobble uridine modification
I5818_RS25895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5818_RS25900	COG1847	R3H domain protein
I5818_RS25905	COG0706	membrane insertase activity
I5818_RS25910	COG0594	ribonuclease P activity
I5818_RS25915	COG0230	Belongs to the bacterial ribosomal protein bL34 family