locus-tag	class	description
OPU65_RS00020	COG0561	phosphatase activity
OPU65_RS00040	COG2427	Protein of unknown function (DUF1641)
OPU65_RS00045	COG3383	formate dehydrogenase (NAD+) activity
OPU65_RS00050	COG5609	conserved protein (DUF2294)
OPU65_RS00060	COG2755	lipolytic protein G-D-S-L family
OPU65_RS00075	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
OPU65_RS00080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OPU65_RS00085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OPU65_RS00090	COG1534	Rna-binding protein
OPU65_RS00095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OPU65_RS00100	COG1713	HD superfamily hydrolase involved in NAD metabolism
OPU65_RS00105	COG0799	negative regulation of ribosome biogenesis
OPU65_RS00110	COG2226	methyltransferase
OPU65_RS00115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OPU65_RS00120	COG1555	photosystem II stabilization
OPU65_RS00120	COG1596	polysaccharide export
OPU65_RS00125	COG2131	deaminase
OPU65_RS00130	COG2333	competence protein COMEC
OPU65_RS00130	COG0658	competence protein
OPU65_RS00140	COG1466	dna polymerase III delta subunit
OPU65_RS00145	COG2249	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS00150	COG1733	regulation of RNA biosynthetic process
OPU65_RS00160	COG0268	Binds directly to 16S ribosomal RNA
OPU65_RS00165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OPU65_RS00170	COG0860	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS00180	COG0481	GTPase activity
OPU65_RS00185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OPU65_RS00190	COG1420	regulation of RNA biosynthetic process
OPU65_RS00195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OPU65_RS00200	COG0443	Heat shock 70 kDa protein
OPU65_RS00205	COG0484	heat shock protein binding
OPU65_RS00210	COG2264	protein methyltransferase activity
OPU65_RS00215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OPU65_RS00220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OPU65_RS00225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OPU65_RS00230	COG1283	sodium-dependent phosphate transmembrane transporter activity
OPU65_RS00235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OPU65_RS00240	COG1610	YqeY-like protein
OPU65_RS00245	COG1030	water channel activity
OPU65_RS00250	COG4864	UPF0365 protein
OPU65_RS00265	COG0561	phosphatase activity
OPU65_RS00270	COG1702	phosphate starvation-inducible protein PhoH
OPU65_RS00275	COG1480	7TM receptor with intracellular HD hydrolase
OPU65_RS00280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OPU65_RS00285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OPU65_RS00290	COG0295	cytidine deaminase activity
OPU65_RS00295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OPU65_RS00305	COG1381	Involved in DNA repair and RecF pathway recombination
OPU65_RS00310	COG0752	glycyl-tRNA synthetase alpha subunit
OPU65_RS00315	COG0751	glycine-tRNA ligase activity
OPU65_RS00320	COG0517	IMP dehydrogenase activity
OPU65_RS00325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OPU65_RS00330	COG1671	Belongs to the UPF0178 family
OPU65_RS00335	COG0358	DNA primase activity
OPU65_RS00340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OPU65_RS00345	COG2010	Cytochrome c
OPU65_RS00360	COG5444	nuclease activity
OPU65_RS00390	COG5444	nuclease activity
OPU65_RS00410	COG2384	SAM-dependent methyltransferase
OPU65_RS00415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OPU65_RS00420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OPU65_RS00430	COG0513	Belongs to the DEAD box helicase family
OPU65_RS00435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OPU65_RS00445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS00450	COG1121	(ABC) transporter
OPU65_RS00455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OPU65_RS00460	COG0735	belongs to the Fur family
OPU65_RS00465	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
OPU65_RS00470	COG4709	membrane
OPU65_RS00475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OPU65_RS00480	COG1388	LysM domain
OPU65_RS00485	COG5521	maltodextrose utilization protein MalA
OPU65_RS00490	COG2839	Protein conserved in bacteria
OPU65_RS00495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OPU65_RS00505	COG0477	Major facilitator Superfamily
OPU65_RS00510	COG0768	penicillin binding
OPU65_RS00515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OPU65_RS00520	COG0573	inorganic phosphate transmembrane transporter activity
OPU65_RS00525	COG0581	inorganic phosphate transmembrane transporter activity
OPU65_RS00530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OPU65_RS00535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OPU65_RS00580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OPU65_RS00595	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS00600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OPU65_RS00605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OPU65_RS00615	COG0705	Rhomboid family
OPU65_RS00615	COG0457	Tetratricopeptide repeat
OPU65_RS00625	COG0697	spore germination
OPU65_RS00630	COG4483	Protein conserved in bacteria
OPU65_RS00635	COG1940	carbohydrate kinase activity
OPU65_RS00640	COG1368	sulfuric ester hydrolase activity
OPU65_RS00650	COG2866	Carboxypeptidase
OPU65_RS00660	COG0011	TIGRFAM Protein of
OPU65_RS00670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS00680	COG1393	Belongs to the ArsC family
OPU65_RS00690	COG1366	Belongs to the anti-sigma-factor antagonist family
OPU65_RS00695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OPU65_RS00700	COG1459	type II secretion system
OPU65_RS00705	COG4537	Required for transformation and DNA binding
OPU65_RS00710	COG4970	Tfp pilus assembly protein FimT
OPU65_RS00720	COG4940	Competence protein ComGF
OPU65_RS00745	COG0681	Belongs to the peptidase S26 family
OPU65_RS00770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OPU65_RS00775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OPU65_RS00780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OPU65_RS00785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OPU65_RS00790	COG0517	IMP dehydrogenase activity
OPU65_RS00790	COG4175	Glycine betaine
OPU65_RS00795	COG4176	ABC-type proline glycine betaine transport system permease component
OPU65_RS00800	COG2113	Glycine betaine
OPU65_RS00805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OPU65_RS00815	COG1321	iron dependent repressor
OPU65_RS00820	COG1752	Esterase of the alpha-beta hydrolase superfamily
OPU65_RS00830	COG3872	metal-dependent enzyme
OPU65_RS00840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OPU65_RS00845	COG0006	proline dipeptidase activity
OPU65_RS00850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OPU65_RS00860	COG3854	ATPases associated with a variety of cellular activities
OPU65_RS00900	COG0511	ligase activity, forming carbon-carbon bonds
OPU65_RS00905	COG0439	Biotin carboxylase
OPU65_RS00910	COG1302	Protein conserved in bacteria
OPU65_RS00915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OPU65_RS00920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OPU65_RS00925	COG1570	exodeoxyribonuclease VII activity
OPU65_RS00930	COG1722	exodeoxyribonuclease VII activity
OPU65_RS00935	COG0142	geranyltranstransferase activity
OPU65_RS00940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OPU65_RS00945	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OPU65_RS00950	COG1438	arginine binding
OPU65_RS00955	COG0497	DNA recombination
OPU65_RS00960	COG0750	zinc metalloprotease
OPU65_RS00965	COG0745	RESPONSE REGULATOR receiver
OPU65_RS00990	COG0860	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS00995	COG0584	glycerophosphoryl diester phosphodiesterase
OPU65_RS01005	COG3829	transcription factor binding
OPU65_RS01005	COG3290	protein histidine kinase activity
OPU65_RS01010	COG0280	phosphate acetyltransferase
OPU65_RS01020	COG3426	butyrate kinase activity
OPU65_RS01025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OPU65_RS01030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OPU65_RS01035	COG0022	dehydrogenase e1 component
OPU65_RS01040	COG0508	dehydrogenase complex catalyzes the overall conversion of
OPU65_RS01045	COG1597	lipid kinase activity
OPU65_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OPU65_RS01060	COG0765	amino acid transport
OPU65_RS01065	COG1126	abc transporter atp-binding protein
OPU65_RS01070	COG4129	membrane
OPU65_RS01080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OPU65_RS01085	COG2195	Cleaves the N-terminal amino acid of tripeptides
OPU65_RS01090	COG0706	membrane insertase activity
OPU65_RS01100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OPU65_RS01105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OPU65_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS01115	COG1785	Belongs to the alkaline phosphatase family
OPU65_RS01120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS01125	COG1447	Phosphotransferase system cellobiose-specific component IIA
OPU65_RS01130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS01135	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS01140	COG2188	Transcriptional regulator
OPU65_RS01145	COG2358	TRAP transporter, solute receptor (TAXI family
OPU65_RS01160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OPU65_RS01165	COG1234	tRNA 3'-trailer cleavage
OPU65_RS01170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OPU65_RS01175	COG0596	Alpha beta hydrolase
OPU65_RS01180	COG1902	pentaerythritol trinitrate reductase activity
OPU65_RS01185	COG4187	Peptidase family M20/M25/M40
OPU65_RS01190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OPU65_RS01195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS01200	COG0300	oxidoreductase activity
OPU65_RS01205	COG4195	phage-related replication protein
OPU65_RS01215	COG2814	Major facilitator Superfamily
OPU65_RS01220	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OPU65_RS01240	COG0745	RESPONSE REGULATOR receiver
OPU65_RS01245	COG2205	protein histidine kinase activity
OPU65_RS01270	COG1131	(ABC) transporter
OPU65_RS01285	COG1072	(Pantothenic acid kinase))
OPU65_RS01290	COG0346	lactoylglutathione lyase activity
OPU65_RS01295	COG2211	Major facilitator Superfamily
OPU65_RS01305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OPU65_RS01320	COG0534	Mate efflux family protein
OPU65_RS01330	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS01340	COG0601	transmembrane transport
OPU65_RS01345	COG0747	negative chemotaxis
OPU65_RS01355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
OPU65_RS01370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OPU65_RS01370	COG0456	acetyltransferase
OPU65_RS01380	COG4918	Iron-sulphur cluster biosynthesis
OPU65_RS01390	COG1073	alpha beta
OPU65_RS01400	COG0667	Aldo Keto reductase
OPU65_RS01410	COG1309	transcriptional regulator
OPU65_RS01420	COG0494	nUDIX hydrolase
OPU65_RS01425	COG1379	DNA repair
OPU65_RS01430	COG2153	protein acetylation
OPU65_RS01450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS01455	COG1300	Membrane
OPU65_RS01460	COG0735	belongs to the Fur family
OPU65_RS01475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OPU65_RS01480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OPU65_RS01485	COG1686	Belongs to the peptidase S11 family
OPU65_RS01520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OPU65_RS01535	COG0697	spore germination
OPU65_RS01545	COG0019	diaminopimelate decarboxylase activity
OPU65_RS01550	COG4195	phage-related replication protein
OPU65_RS01555	COG4086	secreted protein
OPU65_RS01560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OPU65_RS01565	COG0457	Tetratricopeptide repeat
OPU65_RS01595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OPU65_RS01595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OPU65_RS01600	COG0307	riboflavin synthase, alpha
OPU65_RS01605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OPU65_RS01605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OPU65_RS01610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OPU65_RS01615	COG0456	acetyltransferase
OPU65_RS01620	COG1547	Domain of unknown function (DUF309)
OPU65_RS01630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OPU65_RS01635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OPU65_RS01645	COG1686	Belongs to the peptidase S11 family
OPU65_RS01650	COG2715	membrane protein required for spore maturation
OPU65_RS01655	COG0700	Nucleoside recognition
OPU65_RS01660	COG1187	pseudouridine synthase activity
OPU65_RS01665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS01670	COG1333	cytochrome c biogenesis protein
OPU65_RS01675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OPU65_RS01680	COG0745	RESPONSE REGULATOR receiver
OPU65_RS01685	COG5002	protein histidine kinase activity
OPU65_RS01690	COG0745	RESPONSE REGULATOR receiver
OPU65_RS01700	COG1316	TRANSCRIPTIONal
OPU65_RS01705	COG1595	DNA-templated transcription, initiation
OPU65_RS01715	COG0739	heme binding
OPU65_RS01720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OPU65_RS01725	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OPU65_RS01730	COG1141	Ferredoxin
OPU65_RS01735	COG4955	Helix-turn-helix domain
OPU65_RS01740	COG0514	ATP-dependent DNA helicase (RecQ)
OPU65_RS01745	COG1266	CAAX protease self-immunity
OPU65_RS01750	COG1388	LysM domain
OPU65_RS01760	COG1408	metallophosphoesterase
OPU65_RS01765	COG4862	establishment of competence for transformation
OPU65_RS01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OPU65_RS01775	COG0492	ferredoxin-NADP+ reductase activity
OPU65_RS01785	COG2339	peptidase activity
OPU65_RS01790	COG3773	Cell wall hydrolase
OPU65_RS01790	COG3409	Peptidoglycan-binding domain 1 protein
OPU65_RS01795	COG2959	enzyme of heme biosynthesis
OPU65_RS01805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OPU65_RS01810	COG0539	negative regulation of cytoplasmic translation
OPU65_RS01815	COG1304	FMN binding
OPU65_RS01840	COG1160	GTP binding
OPU65_RS01845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OPU65_RS01860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OPU65_RS01865	COG0776	regulation of translation
OPU65_RS01880	COG0142	geranyltranstransferase activity
OPU65_RS01885	COG2226	methyltransferase
OPU65_RS01890	COG0142	geranyltranstransferase activity
OPU65_RS01895	COG0105	UTP biosynthetic process
OPU65_RS01900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OPU65_RS01905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OPU65_RS01910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OPU65_RS01915	COG4401	Chorismate mutase type I
OPU65_RS01920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OPU65_RS01925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OPU65_RS01930	COG0134	indole-3-glycerol-phosphate synthase activity
OPU65_RS01935	COG0135	phosphoribosylanthranilate isomerase activity
OPU65_RS01940	COG0133	tryptophan synthase activity
OPU65_RS01945	COG0159	tryptophan synthase activity
OPU65_RS01950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OPU65_RS01955	COG0287	Prephenate dehydrogenase
OPU65_RS01960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OPU65_RS01965	COG0457	Tetratricopeptide repeat
OPU65_RS01970	COG5582	Belongs to the UPF0302 family
OPU65_RS01980	COG0723	plastoquinol--plastocyanin reductase activity
OPU65_RS01985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OPU65_RS01990	COG2010	Cytochrome c
OPU65_RS01990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OPU65_RS02000	COG4347	Protein of unknown function (DUF1405)
OPU65_RS02010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS02015	COG1694	Mazg nucleotide pyrophosphohydrolase
OPU65_RS02020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OPU65_RS02025	COG1803	Methylglyoxal synthase
OPU65_RS02030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OPU65_RS02035	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS02040	COG0617	tRNA 3'-terminal CCA addition
OPU65_RS02050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OPU65_RS02055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OPU65_RS02060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OPU65_RS02065	COG1199	ATP-dependent helicase activity
OPU65_RS02065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OPU65_RS02075	COG5353	protein conserved in bacteria
OPU65_RS02080	COG0436	Aminotransferase
OPU65_RS02085	COG0017	Asparaginyl-tRNA synthetase
OPU65_RS02090	COG3935	DnaD domain protein
OPU65_RS02095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OPU65_RS02105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OPU65_RS02105	COG4499	WXG100 protein secretion system (Wss), protein YukC
OPU65_RS02110	COG3331	DNA recombination
OPU65_RS02145	COG0071	Belongs to the small heat shock protein (HSP20) family
OPU65_RS02150	COG2190	(PTS) system
OPU65_RS02155	COG1111	helicase
OPU65_RS02155	COG1205	dead DEAH box helicase
OPU65_RS02160	COG3359	exonuclease
OPU65_RS02170	COG4474	Belongs to the UPF0398 family
OPU65_RS02175	COG3599	regulation of cell shape
OPU65_RS02185	COG0116	Belongs to the methyltransferase superfamily
OPU65_RS02205	COG1199	ATP-dependent helicase activity
OPU65_RS02215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OPU65_RS02220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OPU65_RS02225	COG2233	PERMEase
OPU65_RS02235	COG3424	synthase
OPU65_RS02240	COG1755	Isoprenylcysteine carboxyl methyltransferase
OPU65_RS02250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OPU65_RS02265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OPU65_RS02275	COG0328	RNA-DNA hybrid ribonuclease activity
OPU65_RS02280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OPU65_RS02285	COG0328	RNA-DNA hybrid ribonuclease activity
OPU65_RS02305	COG1278	Cold shock
OPU65_RS02315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OPU65_RS02320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OPU65_RS02325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OPU65_RS02330	COG0386	Belongs to the glutathione peroxidase family
OPU65_RS02335	COG1418	mRNA catabolic process
OPU65_RS02340	COG1413	lyase activity
OPU65_RS02345	COG0129	dihydroxy-acid dehydratase activity
OPU65_RS02355	COG2136	Putative SAM-dependent methyltransferase
OPU65_RS02355	COG2521	methyltransferase
OPU65_RS02365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OPU65_RS02370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OPU65_RS02375	COG0204	Acyl-transferase
OPU65_RS02380	COG1272	protein, Hemolysin III
OPU65_RS02385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OPU65_RS02390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OPU65_RS02405	COG1999	signal sequence binding
OPU65_RS02410	COG2755	lipolytic protein G-D-S-L family
OPU65_RS02415	COG4698	Protein conserved in bacteria
OPU65_RS02430	COG0534	Mate efflux family protein
OPU65_RS02445	COG1846	Transcriptional regulator
OPU65_RS02450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OPU65_RS02455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OPU65_RS02460	COG0456	acetyltransferase
OPU65_RS02475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OPU65_RS02480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OPU65_RS02485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OPU65_RS02490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OPU65_RS02495	COG0456	acetyltransferase
OPU65_RS02500	COG1509	lysine 2,3-aminomutase activity
OPU65_RS02510	COG4479	Belongs to the UPF0346 family
OPU65_RS02530	COG0671	phosphoesterase, PA-phosphatase related
OPU65_RS02535	COG0671	phosphoesterase, PA-phosphatase related
OPU65_RS02555	COG0701	Predicted permease
OPU65_RS02560	COG0813	purine-nucleoside phosphorylase activity
OPU65_RS02565	COG1876	peptidase activity
OPU65_RS02575	COG2226	methyltransferase
OPU65_RS02580	COG3409	Peptidoglycan-binding domain 1 protein
OPU65_RS02580	COG0793	Belongs to the peptidase S41A family
OPU65_RS02590	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS02600	COG2022	thiamine diphosphate biosynthetic process
OPU65_RS02645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OPU65_RS02650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS02660	COG0400	carboxylic ester hydrolase activity
OPU65_RS02665	COG0778	Nitroreductase
OPU65_RS02670	COG1733	regulation of RNA biosynthetic process
OPU65_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS02685	COG4305	rare lipoprotein A
OPU65_RS02695	COG2962	Rard protein
OPU65_RS02705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OPU65_RS02710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OPU65_RS02715	COG0534	Mate efflux family protein
OPU65_RS02720	COG1388	LysM domain
OPU65_RS02720	COG0791	NLP P60 protein
OPU65_RS02725	COG2032	superoxide dismutase activity
OPU65_RS02730	COG0714	Associated with various cellular activities
OPU65_RS02740	COG0567	Dehydrogenase, E1 component
OPU65_RS02745	COG0508	dehydrogenase complex catalyzes the overall conversion of
OPU65_RS02750	COG0385	Bile acid
OPU65_RS02755	COG0733	neurotransmitter:sodium symporter activity
OPU65_RS02765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OPU65_RS02770	COG1657	PFAM Prenyltransferase squalene oxidase
OPU65_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS02805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OPU65_RS02810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OPU65_RS02815	COG2318	DinB family
OPU65_RS02835	COG3848	Pyruvate phosphate dikinase
OPU65_RS02835	COG0574	Belongs to the PEP-utilizing enzyme family
OPU65_RS02845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OPU65_RS02850	COG1280	lysine exporter protein (LysE YggA)
OPU65_RS02865	COG2267	carboxylic ester hydrolase activity
OPU65_RS02880	COG0402	S-adenosylhomocysteine deaminase activity
OPU65_RS02905	COG2350	Protein conserved in bacteria
OPU65_RS02945	COG2427	Protein of unknown function (DUF1641)
OPU65_RS02995	COG0514	ATP-dependent DNA helicase (RecQ)
OPU65_RS03000	COG3584	3D domain protein
OPU65_RS03000	COG1388	LysM domain
OPU65_RS03005	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS03025	COG2322	membrane
OPU65_RS03045	COG1086	Polysaccharide biosynthesis protein
OPU65_RS03050	COG0741	lytic transglycosylase activity
OPU65_RS03055	COG0531	amino acid
OPU65_RS03070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS03075	COG0640	Transcriptional regulator
OPU65_RS03085	COG2378	regulation of single-species biofilm formation
OPU65_RS03095	COG3708	Transcriptional regulator
OPU65_RS03100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS03105	COG1309	transcriptional regulator
OPU65_RS03135	COG1846	Transcriptional regulator
OPU65_RS03140	COG1309	transcriptional regulator
OPU65_RS03150	COG1404	Belongs to the peptidase S8 family
OPU65_RS03155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OPU65_RS03165	COG0488	(ABC) transporter
OPU65_RS03175	COG0697	spore germination
OPU65_RS03180	COG0531	amino acid
OPU65_RS03185	COG0531	amino acid
OPU65_RS03200	COG2814	Major facilitator Superfamily
OPU65_RS03205	COG1846	Transcriptional regulator
OPU65_RS03210	COG0243	molybdopterin cofactor binding
OPU65_RS03215	COG0477	Major facilitator Superfamily
OPU65_RS03220	COG3848	Pyruvate phosphate dikinase
OPU65_RS03220	COG0574	Belongs to the PEP-utilizing enzyme family
OPU65_RS03225	COG0300	oxidoreductase activity
OPU65_RS03250	COG1846	Transcriptional regulator
OPU65_RS03270	COG0583	DNA-binding transcription factor activity
OPU65_RS03275	COG0069	glutamate synthase activity
OPU65_RS03275	COG0070	glutamate synthase
OPU65_RS03275	COG0067	glutamate synthase
OPU65_RS03280	COG0493	'glutamate synthase
OPU65_RS03295	COG0463	Glycosyl transferase, family 2
OPU65_RS03300	COG2814	Major facilitator Superfamily
OPU65_RS03305	COG4948	Mandelate Racemase Muconate Lactonizing
OPU65_RS03310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS03315	COG1809	phosphosulfolactate synthase activity
OPU65_RS03320	COG0175	sulfate reduction
OPU65_RS03325	COG0306	phosphate transporter
OPU65_RS03335	COG2323	membrane
OPU65_RS03345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OPU65_RS03350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OPU65_RS03355	COG1733	regulation of RNA biosynthetic process
OPU65_RS03360	COG2249	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS03365	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS03370	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS03385	COG0439	Biotin carboxylase
OPU65_RS03390	COG0511	ligase activity, forming carbon-carbon bonds
OPU65_RS03395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OPU65_RS03400	COG1024	Enoyl-CoA hydratase
OPU65_RS03405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OPU65_RS03410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OPU65_RS03420	COG0166	Belongs to the GPI family
OPU65_RS03430	COG1252	NADH dehydrogenase
OPU65_RS03435	COG1309	transcriptional regulator
OPU65_RS03455	COG2027	D-alanyl-D-alanine carboxypeptidase
OPU65_RS03460	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS03470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OPU65_RS03475	COG2404	hydrolase activity, acting on ester bonds
OPU65_RS03495	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
OPU65_RS03505	COG0640	Transcriptional regulator
OPU65_RS03510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OPU65_RS03515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OPU65_RS03520	COG1609	Transcriptional regulator
OPU65_RS03545	COG1312	Catalyzes the dehydration of D-mannonate
OPU65_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS03555	COG1725	Transcriptional regulator
OPU65_RS03570	COG3711	transcriptional antiterminator
OPU65_RS03570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS03590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS03590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS03590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS03595	COG1482	cell wall glycoprotein biosynthetic process
OPU65_RS03600	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS03605	COG2084	Dehydrogenase
OPU65_RS03610	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS03615	COG1024	Enoyl-CoA hydratase
OPU65_RS03650	COG1114	Component of the transport system for branched-chain amino acids
OPU65_RS03655	COG3420	alginic acid biosynthetic process
OPU65_RS03680	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
OPU65_RS03690	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
OPU65_RS03710	COG2223	nitrite transmembrane transporter activity
OPU65_RS03715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OPU65_RS03725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OPU65_RS03730	COG0535	radical SAM domain protein
OPU65_RS03745	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OPU65_RS03750	COG1140	nitrate reductase beta subunit
OPU65_RS03755	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
OPU65_RS03760	COG2181	nitrate reductase activity
OPU65_RS03770	COG1115	amino acid carrier protein
OPU65_RS03795	COG2160	L-arabinose isomerase activity
OPU65_RS03810	COG1609	Transcriptional regulator
OPU65_RS03815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OPU65_RS03820	COG0187	DNA topoisomerase II activity
OPU65_RS03825	COG1832	CoA-binding protein
OPU65_RS03830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OPU65_RS03835	COG4841	protein insertion into membrane
OPU65_RS03855	COG0824	Thioesterase
OPU65_RS03875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS03880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OPU65_RS03895	COG0071	Belongs to the small heat shock protein (HSP20) family
OPU65_RS03905	COG4846	Membrane protein involved in cytochrome C biogenesis
OPU65_RS03910	COG2201	protein-glutamate methylesterase activity
OPU65_RS03915	COG0785	Cytochrome C biogenesis protein
OPU65_RS03925	COG3763	UPF0154 protein
OPU65_RS03935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OPU65_RS03940	COG4224	UPF0291 protein
OPU65_RS03945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OPU65_RS03950	COG1388	LysM domain
OPU65_RS03955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OPU65_RS03960	COG3209	COG3209 Rhs family protein
OPU65_RS03990	COG0655	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS03995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OPU65_RS04000	COG0346	lactoylglutathione lyase activity
OPU65_RS04005	COG0778	Nitroreductase
OPU65_RS04010	COG1846	Transcriptional regulator
OPU65_RS04035	COG3546	catalase activity
OPU65_RS04040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS04060	COG2076	Multidrug Resistance protein
OPU65_RS04065	COG2076	Multidrug Resistance protein
OPU65_RS04070	COG1309	transcriptional regulator
OPU65_RS04110	COG1073	alpha beta
OPU65_RS04135	COG5444	nuclease activity
OPU65_RS04175	COG5434	Belongs to the glycosyl hydrolase 28 family
OPU65_RS04180	COG1388	LysM domain
OPU65_RS04180	COG1705	Flagellar rod assembly protein muramidase FlgJ
OPU65_RS04255	COG1802	Transcriptional regulator
OPU65_RS04255	COG4626	Terminase
OPU65_RS04370	COG3645	SOS response
OPU65_RS04370	COG3646	Phage regulatory protein
OPU65_RS04390	COG4974	Belongs to the 'phage' integrase family
OPU65_RS04395	COG0174	glutamine synthetase
OPU65_RS04400	COG0789	Transcriptional regulator
OPU65_RS04405	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
OPU65_RS04410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OPU65_RS04415	COG0464	growth
OPU65_RS04430	COG1695	Transcriptional regulator
OPU65_RS04440	COG0829	nickel cation binding
OPU65_RS04445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OPU65_RS04450	COG0830	nickel cation binding
OPU65_RS04455	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OPU65_RS04465	COG0832	Belongs to the urease beta subunit family
OPU65_RS04475	COG4413	Urea transporter
OPU65_RS04485	COG0457	Tetratricopeptide repeat
OPU65_RS04490	COG2814	Major facilitator Superfamily
OPU65_RS04530	COG5444	nuclease activity
OPU65_RS04535	COG5444	nuclease activity
OPU65_RS04550	COG1404	Belongs to the peptidase S8 family
OPU65_RS04580	COG0697	spore germination
OPU65_RS04585	COG1802	Transcriptional regulator
OPU65_RS04605	COG4112	unkown
OPU65_RS04610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OPU65_RS04615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OPU65_RS04620	COG1780	Probably involved in ribonucleotide reductase function
OPU65_RS04630	COG1923	regulation of RNA biosynthetic process
OPU65_RS04635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OPU65_RS04650	COG2076	Multidrug Resistance protein
OPU65_RS04655	COG2076	Multidrug Resistance protein
OPU65_RS04660	COG1764	response to oxidative stress
OPU65_RS04680	COG1309	transcriptional regulator
OPU65_RS04685	COG3858	chitin binding
OPU65_RS04685	COG1388	LysM domain
OPU65_RS04695	COG5577	PFAM Coat F domain
OPU65_RS04700	COG0531	amino acid
OPU65_RS04705	COG1819	glycosyl
OPU65_RS04710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OPU65_RS04715	COG0398	Pfam SNARE associated Golgi protein
OPU65_RS04720	COG0393	Putative heavy-metal-binding
OPU65_RS04730	COG2814	Major facilitator Superfamily
OPU65_RS04735	COG3263	regulation of cellular component size
OPU65_RS04740	COG3619	membrane
OPU65_RS04745	COG1231	oxidoreductase activity
OPU65_RS04775	COG0523	cobalamin synthesis protein
OPU65_RS04785	COG3209	COG3209 Rhs family protein
OPU65_RS04810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OPU65_RS04815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OPU65_RS04820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OPU65_RS04835	COG4550	Control of competence regulator ComK, YlbF/YmcA
OPU65_RS04840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OPU65_RS04850	COG1063	alcohol dehydrogenase
OPU65_RS04860	COG2359	stage V sporulation protein S
OPU65_RS04865	COG1692	metallophosphoesterase
OPU65_RS04870	COG1418	mRNA catabolic process
OPU65_RS04880	COG1546	Belongs to the CinA family
OPU65_RS04880	COG1058	Belongs to the CinA family
OPU65_RS04885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OPU65_RS04890	COG1426	Protein conserved in bacteria
OPU65_RS04905	COG0300	oxidoreductase activity
OPU65_RS04910	COG0612	Peptidase, M16
OPU65_RS04915	COG0612	Peptidase, M16
OPU65_RS04920	COG2814	Major facilitator Superfamily
OPU65_RS04925	COG2188	Transcriptional regulator
OPU65_RS04930	COG1674	ftsk spoiiie
OPU65_RS04930	COG4980	gas vesicle protein
OPU65_RS04940	COG0740	serine-type endopeptidase activity
OPU65_RS04945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OPU65_RS04955	COG0527	aspartate kinase activity
OPU65_RS04960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OPU65_RS04965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OPU65_RS04970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OPU65_RS04975	COG1873	PFAM PRC-barrel domain
OPU65_RS04980	COG0612	Peptidase, M16
OPU65_RS04985	COG0726	polysaccharide deacetylase
OPU65_RS04990	COG1185	polyribonucleotide nucleotidyltransferase activity
OPU65_RS04995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OPU65_RS05000	COG0196	riboflavin kinase activity
OPU65_RS05005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OPU65_RS05010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OPU65_RS05015	COG1550	Protein conserved in bacteria
OPU65_RS05020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OPU65_RS05025	COG1358	cellular component organization or biogenesis
OPU65_RS05030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OPU65_RS05035	COG0195	Participates in both transcription termination and antitermination
OPU65_RS05040	COG0779	Required for maturation of 30S ribosomal subunits
OPU65_RS05050	COG2176	DNA-directed DNA polymerase activity
OPU65_RS05055	COG0442	prolyl-tRNA aminoacylation
OPU65_RS05060	COG0750	zinc metalloprotease
OPU65_RS05065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OPU65_RS05070	COG4589	Belongs to the CDS family
OPU65_RS05075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OPU65_RS05080	COG0233	cytoplasmic translational termination
OPU65_RS05085	COG0528	UMP kinase activity
OPU65_RS05090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OPU65_RS05095	COG0052	Belongs to the universal ribosomal protein uS2 family
OPU65_RS05105	COG1191	sigma factor activity
OPU65_RS05110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OPU65_RS05115	COG1776	CheC inhibitor of MCP methylation
OPU65_RS05120	COG0835	chemotaxis
OPU65_RS05125	COG0643	Histidine kinase
OPU65_RS05125	COG2198	Histidine kinase
OPU65_RS05130	COG2201	protein-glutamate methylesterase activity
OPU65_RS05135	COG0455	bacterial-type flagellum organization
OPU65_RS05140	COG1419	protein localization to endoplasmic reticulum
OPU65_RS05145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OPU65_RS05150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OPU65_RS05155	COG1684	flagellar biosynthetic protein fliR
OPU65_RS05160	COG1987	bacterial-type flagellum assembly
OPU65_RS05165	COG1338	Plays a role in the flagellum-specific transport system
OPU65_RS05170	COG3190	flagellar
OPU65_RS05175	COG2201	protein-glutamate methylesterase activity
OPU65_RS05180	COG1776	CheC inhibitor of MCP methylation
OPU65_RS05180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OPU65_RS05185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OPU65_RS05190	COG1580	Controls the rotational direction of flagella during chemotaxis
OPU65_RS05195	COG1582	Flagellar protein (FlbD)
OPU65_RS05200	COG4786	Flagellar basal body rod
OPU65_RS05205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OPU65_RS05210	COG3144	bacterial-type flagellum assembly
OPU65_RS05215	COG2882	bacterial-type flagellum organization
OPU65_RS05220	COG1157	protein secretion by the type III secretion system
OPU65_RS05225	COG1317	bacterial-type flagellum organization
OPU65_RS05230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OPU65_RS05235	COG1766	The M ring may be actively involved in energy transduction
OPU65_RS05240	COG1677	Flagellar hook-basal body complex protein FliE
OPU65_RS05245	COG1558	bacterial-type flagellum-dependent cell motility
OPU65_RS05250	COG1815	bacterial-type flagellum-dependent cell motility
OPU65_RS05255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OPU65_RS05260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OPU65_RS05265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OPU65_RS05270	COG4974	Belongs to the 'phage' integrase family
OPU65_RS05275	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
OPU65_RS05280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OPU65_RS05285	COG0758	DNA mediated transformation
OPU65_RS05290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OPU65_RS05295	COG0045	succinate-CoA ligase (ADP-forming) activity
OPU65_RS05300	COG2257	FlhB HrpN YscU SpaS Family
OPU65_RS05310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OPU65_RS05315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OPU65_RS05320	COG0335	large ribosomal subunit rRNA binding
OPU65_RS05325	COG0336	Belongs to the RNA methyltransferase TrmD family
OPU65_RS05330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OPU65_RS05340	COG1837	Belongs to the UPF0109 family
OPU65_RS05345	COG0228	four-way junction DNA binding
OPU65_RS05350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OPU65_RS05355	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OPU65_RS05360	COG0552	protein localization to endoplasmic reticulum
OPU65_RS05365	COG1196	nuclear chromosome segregation
OPU65_RS05370	COG0571	ribonuclease III activity
OPU65_RS05375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OPU65_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS05385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OPU65_RS05390	COG0416	fatty acid biosynthetic process
OPU65_RS05395	COG1349	DNA-binding transcription factor activity
OPU65_RS05400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OPU65_RS05405	COG1760	l-serine dehydratase
OPU65_RS05410	COG1760	l-serine dehydratase
OPU65_RS05415	COG1461	Dihydroxyacetone kinase
OPU65_RS05420	COG1302	Protein conserved in bacteria
OPU65_RS05425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OPU65_RS05435	COG1564	THIamine pyrophosphokinase
OPU65_RS05440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OPU65_RS05445	COG1162	GTPase activity
OPU65_RS05450	COG0515	serine threonine protein kinase
OPU65_RS05450	COG2815	serine threonine protein kinase
OPU65_RS05455	COG0631	protein serine/threonine phosphatase activity
OPU65_RS05460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OPU65_RS05465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OPU65_RS05465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OPU65_RS05470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OPU65_RS05475	COG0242	peptide deformylase activity
OPU65_RS05480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OPU65_RS05485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OPU65_RS05490	COG1758	RNA polymerase activity
OPU65_RS05495	COG0194	GDP metabolic process
OPU65_RS05500	COG2052	Domain of unknown function (DUF370)
OPU65_RS05505	COG1561	YicC-like family, N-terminal region
OPU65_RS05510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OPU65_RS05520	COG1648	precorrin-2 dehydrogenase activity
OPU65_RS05525	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
OPU65_RS05530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OPU65_RS05535	COG0529	Catalyzes the synthesis of activated sulfate
OPU65_RS05540	COG2046	Belongs to the sulfate adenylyltransferase family
OPU65_RS05545	COG0306	phosphate transporter
OPU65_RS05550	COG0175	sulfate reduction
OPU65_RS05560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OPU65_RS05565	COG0284	orotidine-5'-phosphate decarboxylase activity
OPU65_RS05570	COG0167	dihydroorotate dehydrogenase activity
OPU65_RS05575	COG0543	2 iron, 2 sulfur cluster binding
OPU65_RS05580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OPU65_RS05585	COG0505	Belongs to the CarA family
OPU65_RS05590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OPU65_RS05595	COG0540	Belongs to the ATCase OTCase family
OPU65_RS05600	COG2233	PERMEase
OPU65_RS05610	COG0564	pseudouridine synthase activity
OPU65_RS05615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OPU65_RS05620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OPU65_RS05625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OPU65_RS05630	COG3599	regulation of cell shape
OPU65_RS05635	COG2302	S4 RNA-binding domain
OPU65_RS05640	COG0762	integral membrane protein
OPU65_RS05645	COG1799	cell septum assembly
OPU65_RS05650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OPU65_RS05655	COG1496	oxidoreductase activity
OPU65_RS05660	COG1873	PFAM PRC-barrel domain
OPU65_RS05665	COG0500	methyltransferase
OPU65_RS05670	COG1119	ATPase activity
OPU65_RS05675	COG1191	sigma factor activity
OPU65_RS05680	COG1191	sigma factor activity
OPU65_RS05690	COG1404	Belongs to the peptidase S8 family
OPU65_RS05690	COG4412	M6 family metalloprotease domain protein
OPU65_RS05705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OPU65_RS05710	COG0849	cell division
OPU65_RS05715	COG3856	small basic protein
OPU65_RS05720	COG3879	Bacterial protein of unknown function (DUF881)
OPU65_RS05730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OPU65_RS05735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OPU65_RS05740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OPU65_RS05745	COG0772	Belongs to the SEDS family
OPU65_RS05750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OPU65_RS05755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OPU65_RS05760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OPU65_RS05765	COG0768	penicillin binding
OPU65_RS05770	COG0768	penicillin binding
OPU65_RS05775	COG4839	cell division protein FtsL
OPU65_RS05780	COG0275	rRNA processing
OPU65_RS05785	COG2001	Belongs to the MraZ family
OPU65_RS05790	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
OPU65_RS05795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OPU65_RS05800	COG0454	-acetyltransferase
OPU65_RS05810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OPU65_RS05815	COG1399	metal-binding, possibly nucleic acid-binding protein
OPU65_RS05820	COG1323	Belongs to the UPF0348 family
OPU65_RS05825	COG3480	Lon protease (S16) C-terminal proteolytic domain
OPU65_RS05830	COG3314	Sporulation integral membrane protein YlbJ
OPU65_RS05835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OPU65_RS05840	COG0742	ribosomal rna small subunit methyltransferase
OPU65_RS05850	COG4471	UPF0298 protein
OPU65_RS05855	COG3679	Belongs to the UPF0342 family
OPU65_RS05875	COG2340	Cysteine-rich secretory protein family
OPU65_RS05880	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
OPU65_RS05890	COG3336	cytochrome c oxidase
OPU65_RS05895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OPU65_RS05900	COG1845	cytochrome c oxidase, subunit III
OPU65_RS05905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OPU65_RS05910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OPU65_RS05910	COG2010	Cytochrome c
OPU65_RS05915	COG0109	protoheme IX farnesyltransferase activity
OPU65_RS05920	COG1612	heme a metabolic process
OPU65_RS05925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OPU65_RS05930	COG0772	Belongs to the SEDS family
OPU65_RS05935	COG4838	Belongs to the UPF0358 family
OPU65_RS05940	COG2066	Belongs to the glutaminase family
OPU65_RS05945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OPU65_RS05950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OPU65_RS05960	COG4896	Protein conserved in bacteria
OPU65_RS05965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OPU65_RS05970	COG1846	Transcriptional regulator
OPU65_RS05980	COG1217	gtp-binding protein TYPA
OPU65_RS05995	COG1595	DNA-templated transcription, initiation
OPU65_RS06015	COG0483	inositol monophosphate 1-phosphatase activity
OPU65_RS06025	COG4493	Belongs to the UPF0637 family
OPU65_RS06030	COG4476	Belongs to the UPF0223 family
OPU65_RS06040	COG1982	Orn Lys Arg decarboxylase major
OPU65_RS06050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS06055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OPU65_RS06060	COG0508	dehydrogenase complex catalyzes the overall conversion of
OPU65_RS06065	COG0022	dehydrogenase e1 component
OPU65_RS06070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OPU65_RS06075	COG0497	DNA recombination
OPU65_RS06085	COG0242	peptide deformylase activity
OPU65_RS06090	COG0561	phosphatase activity
OPU65_RS06095	COG5503	Protein of unknown function (DUF1447)
OPU65_RS06100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OPU65_RS06105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OPU65_RS06115	COG3852	Histidine kinase
OPU65_RS06120	COG2002	toxin-antitoxin pair type II binding
OPU65_RS06125	COG1077	Cell shape determining protein MreB Mrl
OPU65_RS06135	COG2309	aminopeptidase activity
OPU65_RS06145	COG0488	(ABC) transporter
OPU65_RS06165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS06165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS06165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS06170	COG1105	Belongs to the carbohydrate kinase PfkB family
OPU65_RS06175	COG1349	DNA-binding transcription factor activity
OPU65_RS06180	COG0577	efflux transmembrane transporter activity
OPU65_RS06185	COG1136	(ABC) transporter
OPU65_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OPU65_RS06200	COG1132	(ABC) transporter
OPU65_RS06205	COG1132	(ABC) transporter
OPU65_RS06215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OPU65_RS06220	COG0314	molybdopterin synthase activity
OPU65_RS06225	COG1763	Mo-molybdopterin cofactor biosynthetic process
OPU65_RS06230	COG0303	'Molybdopterin
OPU65_RS06235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OPU65_RS06240	COG0746	molybdenum cofactor guanylyltransferase activity
OPU65_RS06255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS06260	COG0450	alkyl hydroperoxide reductase
OPU65_RS06270	COG1473	amidohydrolase
OPU65_RS06275	COG2171	N-acyltransferase activity
OPU65_RS06280	COG0716	FMN binding
OPU65_RS06290	COG0716	FMN binding
OPU65_RS06295	COG0583	DNA-binding transcription factor activity
OPU65_RS06300	COG0517	IMP dehydrogenase activity
OPU65_RS06310	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
OPU65_RS06320	COG4703	Protein of unknown function (DUF1797)
OPU65_RS06330	COG2200	EAL domain
OPU65_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS06340	COG1408	metallophosphoesterase
OPU65_RS06345	COG1376	ErfK ybiS ycfS ynhG family protein
OPU65_RS06350	COG2814	Major facilitator Superfamily
OPU65_RS06360	COG0835	chemotaxis
OPU65_RS06360	COG0784	Response regulator, receiver
OPU65_RS06370	COG1714	RDD family
OPU65_RS06380	COG0436	Aminotransferase
OPU65_RS06385	COG4191	Histidine kinase
OPU65_RS06390	COG0768	penicillin binding
OPU65_RS06395	COG2340	Cysteine-rich secretory protein family
OPU65_RS06400	COG2084	Dehydrogenase
OPU65_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS06410	COG0840	transmembrane signaling receptor activity
OPU65_RS06415	COG0456	acetyltransferase
OPU65_RS06420	COG1533	DNA photolyase activity
OPU65_RS06430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OPU65_RS06435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS06440	COG1263	PTS System
OPU65_RS06440	COG2190	(PTS) system
OPU65_RS06440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS06445	COG3711	transcriptional antiterminator
OPU65_RS06450	COG1609	Transcriptional regulator
OPU65_RS06465	COG0006	proline dipeptidase activity
OPU65_RS06470	COG2217	Heavy metal translocating P-type atpase
OPU65_RS06475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS06480	COG2244	polysaccharide biosynthetic process
OPU65_RS06485	COG3773	Cell wall hydrolase
OPU65_RS06495	COG4873	Protein conserved in bacteria
OPU65_RS06530	COG3655	Transcriptional regulator
OPU65_RS06550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OPU65_RS06555	COG0602	queuosine metabolic process
OPU65_RS06560	COG0720	synthase
OPU65_RS06565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OPU65_RS06575	COG0542	response to heat
OPU65_RS06580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OPU65_RS06585	COG1360	Flagellar Motor Protein
OPU65_RS06590	COG1846	Transcriptional regulator
OPU65_RS06595	COG3852	Histidine kinase
OPU65_RS06605	COG3339	Conserved Protein
OPU65_RS06610	COG0346	lactoylglutathione lyase activity
OPU65_RS06615	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OPU65_RS06620	COG0235	Class ii aldolase
OPU65_RS06620	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
OPU65_RS06625	COG0235	Class ii aldolase
OPU65_RS06625	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
OPU65_RS06630	COG1850	ribulose-bisphosphate carboxylase activity
OPU65_RS06635	COG0436	Aminotransferase
OPU65_RS06640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OPU65_RS06645	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
OPU65_RS06650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
OPU65_RS06660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OPU65_RS06665	COG5002	protein histidine kinase activity
OPU65_RS06670	COG3594	Acyltransferase
OPU65_RS06685	COG0768	penicillin binding
OPU65_RS06690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OPU65_RS06695	COG0501	Belongs to the peptidase M48B family
OPU65_RS06715	COG1191	sigma factor activity
OPU65_RS06725	COG0586	Pfam SNARE associated Golgi protein
OPU65_RS06730	COG5001	Diguanylate cyclase
OPU65_RS06730	COG3300	MHYT domain
OPU65_RS06735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OPU65_RS06740	COG1793	dna ligase
OPU65_RS06740	COG3285	dna ligase
OPU65_RS06745	COG1846	Transcriptional regulator
OPU65_RS06760	COG0789	Transcriptional regulator
OPU65_RS06770	COG2239	Acts as a magnesium transporter
OPU65_RS06780	COG1404	Belongs to the peptidase S8 family
OPU65_RS06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OPU65_RS06800	COG0406	alpha-ribazole phosphatase activity
OPU65_RS06805	COG0590	tRNA wobble adenosine to inosine editing
OPU65_RS06815	COG1764	response to oxidative stress
OPU65_RS06820	COG1846	Transcriptional regulator
OPU65_RS06830	COG1764	response to oxidative stress
OPU65_RS06835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OPU65_RS06840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OPU65_RS06845	COG0788	formyltetrahydrofolate deformylase activity
OPU65_RS06850	COG2076	Multidrug Resistance protein
OPU65_RS06855	COG2076	Multidrug Resistance protein
OPU65_RS06860	COG2318	DinB family
OPU65_RS06880	COG3866	Pectate lyase
OPU65_RS06885	COG2323	membrane
OPU65_RS06890	COG1607	acyl-coa hydrolase
OPU65_RS06895	COG1834	amidinotransferase
OPU65_RS06905	COG4608	Belongs to the ABC transporter superfamily
OPU65_RS06910	COG0791	NLP P60 protein
OPU65_RS06915	COG4948	Mandelate Racemase Muconate Lactonizing
OPU65_RS06920	COG1619	proteins homologs of microcin C7 resistance protein MccF
OPU65_RS06925	COG4166	transmembrane transport
OPU65_RS06930	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS06940	COG0601	transmembrane transport
OPU65_RS06945	COG2362	D-Aminopeptidase
OPU65_RS06950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OPU65_RS06955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OPU65_RS06960	COG0346	lactoylglutathione lyase activity
OPU65_RS06965	COG0531	amino acid
OPU65_RS06970	COG0395	ABC-type sugar transport system, permease component
OPU65_RS06975	COG4209	transmembrane transport
OPU65_RS06980	COG1653	transport
OPU65_RS06990	COG1874	Beta-galactosidase
OPU65_RS06995	COG2755	lipolytic protein G-D-S-L family
OPU65_RS07000	COG0667	Aldo Keto reductase
OPU65_RS07005	COG3401	FG-GAP repeat protein
OPU65_RS07010	COG2755	lipolytic protein G-D-S-L family
OPU65_RS07015	COG3401	FG-GAP repeat protein
OPU65_RS07020	COG5578	integral membrane protein
OPU65_RS07030	COG2755	lipolytic protein G-D-S-L family
OPU65_RS07035	COG2207	Transcriptional regulator
OPU65_RS07040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OPU65_RS07045	COG0395	ABC-type sugar transport system, permease component
OPU65_RS07050	COG1175	transmembrane transport
OPU65_RS07060	COG4753	response regulator
OPU65_RS07060	COG2207	Transcriptional regulator
OPU65_RS07065	COG2972	Histidine kinase
OPU65_RS07070	COG5578	integral membrane protein
OPU65_RS07075	COG0405	Gamma-glutamyltransferase
OPU65_RS07080	COG1392	Phosphate transport regulator
OPU65_RS07085	COG0306	phosphate transporter
OPU65_RS07105	COG2271	Major facilitator Superfamily
OPU65_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS07120	COG1312	Catalyzes the dehydration of D-mannonate
OPU65_RS07125	COG1063	alcohol dehydrogenase
OPU65_RS07130	COG1802	Transcriptional regulator
OPU65_RS07165	COG3778	Protein conserved in bacteria
OPU65_RS07170	COG3299	homolog of phage Mu protein gp47
OPU65_RS07175	COG3628	GPW Gp25 family protein
OPU65_RS07185	COG4193	domain, Protein
OPU65_RS07190	COG1652	LysM domain
OPU65_RS07195	COG3953	SLT domain
OPU65_RS07195	COG5280	Phage tail tape measure protein TP901
OPU65_RS07245	COG4653	Phage capsid family
OPU65_RS07250	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OPU65_RS07255	COG5518	Phage portal protein
OPU65_RS07260	COG1783	phage Terminase large subunit
OPU65_RS07265	COG3728	DNA packaging
OPU65_RS07265	COG5484	DNA packaging
OPU65_RS07270	COG1595	DNA-templated transcription, initiation
OPU65_RS07290	COG1484	DNA-dependent DNA replication
OPU65_RS07295	COG1522	sequence-specific DNA binding
OPU65_RS07310	COG1396	sequence-specific DNA binding
OPU65_RS07315	COG2856	Zn peptidase
OPU65_RS07320	COG4195	phage-related replication protein
OPU65_RS07335	COG1309	transcriptional regulator
OPU65_RS07340	COG2814	Major facilitator Superfamily
OPU65_RS07345	COG1388	LysM domain
OPU65_RS07345	COG3584	3D domain protein
OPU65_RS07355	COG0346	lactoylglutathione lyase activity
OPU65_RS07360	COG0697	spore germination
OPU65_RS07365	COG0583	DNA-binding transcription factor activity
OPU65_RS07370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OPU65_RS07375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OPU65_RS07380	COG0583	DNA-binding transcription factor activity
OPU65_RS07435	COG3507	Belongs to the glycosyl hydrolase 43 family
OPU65_RS07460	COG5505	Protein of unknown function (DUF819)
OPU65_RS07465	COG0626	cystathionine gamma-synthase activity
OPU65_RS07470	COG0626	cystathionine gamma-synthase activity
OPU65_RS07490	COG2382	esterase
OPU65_RS07495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OPU65_RS07500	COG2153	protein acetylation
OPU65_RS07510	COG2246	polysaccharide biosynthetic process
OPU65_RS07515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OPU65_RS07520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OPU65_RS07525	COG0586	Pfam SNARE associated Golgi protein
OPU65_RS07535	COG0210	DNA helicase
OPU65_RS07595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OPU65_RS07600	COG0351	phosphomethylpyrimidine kinase
OPU65_RS07605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OPU65_RS07610	COG2022	thiamine diphosphate biosynthetic process
OPU65_RS07615	COG2104	thiamine diphosphate biosynthetic process
OPU65_RS07625	COG0352	thiamine-phosphate diphosphorylase activity
OPU65_RS07630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OPU65_RS07635	COG0475	glutathione-regulated potassium exporter activity
OPU65_RS07635	COG0569	domain protein
OPU65_RS07640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OPU65_RS07645	COG0564	pseudouridine synthase activity
OPU65_RS07650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OPU65_RS07655	COG2357	RelA SpoT domain protein
OPU65_RS07665	COG4116	CYTH
OPU65_RS07670	COG0741	lytic transglycosylase activity
OPU65_RS07675	COG2346	COG2346, Truncated hemoglobins
OPU65_RS07680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OPU65_RS07690	COG1164	Oligoendopeptidase f
OPU65_RS07695	COG4469	Competence protein
OPU65_RS07700	COG3290	protein histidine kinase activity
OPU65_RS07705	COG4565	transcriptional regulatory protein
OPU65_RS07730	COG4862	establishment of competence for transformation
OPU65_RS07740	COG0861	Integral membrane protein TerC family
OPU65_RS07745	COG1393	Belongs to the ArsC family
OPU65_RS07750	COG0456	acetyltransferase
OPU65_RS07755	COG4608	Belongs to the ABC transporter superfamily
OPU65_RS07760	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS07765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS07770	COG0601	transmembrane transport
OPU65_RS07775	COG4166	transmembrane transport
OPU65_RS07780	COG0180	Tryptophanyl-tRNA synthetase
OPU65_RS07790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS07795	COG0601	transmembrane transport
OPU65_RS07805	COG4608	Belongs to the ABC transporter superfamily
OPU65_RS07810	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS07815	COG5504	Zn-dependent protease
OPU65_RS07820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OPU65_RS07825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OPU65_RS07840	COG1744	ABC transporter substrate-binding protein PnrA-like
OPU65_RS07850	COG2267	carboxylic ester hydrolase activity
OPU65_RS07865	COG1968	undecaprenyl-diphosphatase activity
OPU65_RS07870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OPU65_RS07875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OPU65_RS07880	COG0505	Belongs to the CarA family
OPU65_RS07885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OPU65_RS07890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OPU65_RS07895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OPU65_RS07900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OPU65_RS07905	COG2151	metal-sulfur cluster biosynthetic enzyme
OPU65_RS07910	COG1073	alpha beta
OPU65_RS07915	COG0561	phosphatase activity
OPU65_RS07930	COG0516	GMP reductase activity
OPU65_RS07940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS07945	COG1307	EDD domain protein, DegV family
OPU65_RS07960	COG2996	Protein conserved in bacteria
OPU65_RS07965	COG1666	GTP binding
OPU65_RS07970	COG0646	methionine synthase
OPU65_RS07970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OPU65_RS07975	COG0646	methionine synthase
OPU65_RS07975	COG1410	methionine synthase
OPU65_RS07980	COG2378	regulation of single-species biofilm formation
OPU65_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS07990	COG2153	protein acetylation
OPU65_RS08015	COG0076	glutamate decarboxylase activity
OPU65_RS08025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS08030	COG1279	arginine transmembrane transporter activity
OPU65_RS08055	COG0673	inositol 2-dehydrogenase activity
OPU65_RS08060	COG1609	Transcriptional regulator
OPU65_RS08070	COG2207	Transcriptional regulator
OPU65_RS08070	COG1917	Cupin 2, conserved barrel domain protein
OPU65_RS08075	COG0534	Mate efflux family protein
OPU65_RS08080	COG0347	Belongs to the P(II) protein family
OPU65_RS08085	COG0004	ammonium transporteR
OPU65_RS08090	COG0367	asparagine synthase
OPU65_RS08110	COG0179	Fumarylacetoacetate (FAA) hydrolase
OPU65_RS08120	COG5337	Spore coat protein CotH
OPU65_RS08165	COG0419	ATPase involved in DNA repair
OPU65_RS08170	COG0420	3'-5' exonuclease activity
OPU65_RS08175	COG1074	ATP-dependent DNA helicase activity
OPU65_RS08180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OPU65_RS08185	COG4149	molybdate abc transporter
OPU65_RS08190	COG0725	ABC transporter, periplasmic molybdate-binding protein
OPU65_RS08195	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
OPU65_RS08200	COG0745	RESPONSE REGULATOR receiver
OPU65_RS08205	COG5002	protein histidine kinase activity
OPU65_RS08215	COG4533	DNA binding
OPU65_RS08220	COG0477	Major facilitator Superfamily
OPU65_RS08220	COG2814	Major facilitator Superfamily
OPU65_RS08225	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS08230	COG3546	catalase activity
OPU65_RS08245	COG3180	Ammonia monooxygenase
OPU65_RS08250	COG1486	melibiose metabolic process
OPU65_RS08255	COG0395	ABC-type sugar transport system, permease component
OPU65_RS08260	COG1175	transmembrane transport
OPU65_RS08265	COG1653	transport
OPU65_RS08270	COG1609	Transcriptional regulator
OPU65_RS08280	COG0457	Tetratricopeptide repeat
OPU65_RS08290	COG1404	Belongs to the peptidase S8 family
OPU65_RS08295	COG0681	Belongs to the peptidase S26 family
OPU65_RS08300	COG0398	Pfam SNARE associated Golgi protein
OPU65_RS08310	COG4903	ComK protein
OPU65_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS08325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OPU65_RS08325	COG0723	plastoquinol--plastocyanin reductase activity
OPU65_RS08330	COG0840	transmembrane signaling receptor activity
OPU65_RS08335	COG0406	alpha-ribazole phosphatase activity
OPU65_RS08340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS08345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS08350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OPU65_RS08355	COG0697	spore germination
OPU65_RS08365	COG0501	Belongs to the peptidase M48B family
OPU65_RS08380	COG1396	sequence-specific DNA binding
OPU65_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS08395	COG0095	Lipoate-protein ligase
OPU65_RS08400	COG1234	tRNA 3'-trailer cleavage
OPU65_RS08410	COG1301	dicarboxylic acid transport
OPU65_RS08420	COG1363	Peptidase, m42
OPU65_RS08425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OPU65_RS08430	COG1511	domain protein
OPU65_RS08435	COG1309	transcriptional regulator
OPU65_RS08440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OPU65_RS08445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OPU65_RS08450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OPU65_RS08455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OPU65_RS08460	COG2329	Antibiotic biosynthesis monooxygenase
OPU65_RS08470	COG1473	amidohydrolase
OPU65_RS08480	COG4473	ABC transporter
OPU65_RS08485	COG1131	(ABC) transporter
OPU65_RS08490	COG0537	adenosine 5'-monophosphoramidase activity
OPU65_RS08500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OPU65_RS08515	COG4980	gas vesicle protein
OPU65_RS08520	COG1846	Transcriptional regulator
OPU65_RS08550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OPU65_RS08560	COG3481	metal-dependent phosphohydrolase, HD sub domain
OPU65_RS08565	COG4717	serine-type aminopeptidase activity
OPU65_RS08570	COG0420	3'-5' exonuclease activity
OPU65_RS08575	COG1668	transmembrane transport
OPU65_RS08580	COG4152	abc transporter atp-binding protein
OPU65_RS08600	COG0457	Tetratricopeptide repeat
OPU65_RS08605	COG1024	Enoyl-CoA hydratase
OPU65_RS08610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OPU65_RS08615	COG0561	phosphatase activity
OPU65_RS08620	COG3679	Belongs to the UPF0342 family
OPU65_RS08625	COG4399	Belongs to the UPF0754 family
OPU65_RS08630	COG0189	ligase activity
OPU65_RS08635	COG0189	ligase activity
OPU65_RS08645	COG2508	Transcriptional regulator
OPU65_RS08650	COG3842	ATPase activity
OPU65_RS08675	COG0702	epimerase
OPU65_RS08680	COG1132	(ABC) transporter
OPU65_RS08685	COG1132	(ABC) transporter
OPU65_RS08690	COG0589	response to stress
OPU65_RS08715	COG2017	converts alpha-aldose to the beta-anomer
OPU65_RS08720	COG1757	Na H antiporter
OPU65_RS08730	COG0726	polysaccharide deacetylase
OPU65_RS08740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OPU65_RS08745	COG0668	transmembrane transport
OPU65_RS08755	COG0584	glycerophosphoryl diester phosphodiesterase
OPU65_RS08760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OPU65_RS08765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OPU65_RS08785	COG1253	flavin adenine dinucleotide binding
OPU65_RS08790	COG0789	Transcriptional regulator
OPU65_RS08795	COG1253	flavin adenine dinucleotide binding
OPU65_RS08800	COG0204	Acyl-transferase
OPU65_RS08805	COG0667	Aldo Keto reductase
OPU65_RS08810	COG0662	Cupin 2, conserved barrel domain protein
OPU65_RS08815	COG1595	DNA-templated transcription, initiation
OPU65_RS08835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS08840	COG3708	Transcriptional regulator
OPU65_RS08840	COG2207	Transcriptional regulator
OPU65_RS08845	COG5444	nuclease activity
OPU65_RS08865	COG0733	neurotransmitter:sodium symporter activity
OPU65_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS08875	COG2133	pyrroloquinoline quinone binding
OPU65_RS08880	COG0372	Belongs to the citrate synthase family
OPU65_RS08885	COG0583	DNA-binding transcription factor activity
OPU65_RS08890	COG0791	NLP P60 protein
OPU65_RS08890	COG1388	LysM domain
OPU65_RS08900	COG1017	nitric oxide dioxygenase activity
OPU65_RS08900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OPU65_RS08905	COG1959	2 iron, 2 sulfur cluster binding
OPU65_RS08920	COG0431	NADPH-dependent FMN reductase
OPU65_RS08925	COG2197	response regulator
OPU65_RS08930	COG2203	Gaf domain
OPU65_RS08930	COG4585	Histidine kinase
OPU65_RS08945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OPU65_RS08950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OPU65_RS08955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OPU65_RS08960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OPU65_RS08965	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OPU65_RS08970	COG0604	alcohol dehydrogenase
OPU65_RS08985	COG2116	formate transmembrane transporter activity
OPU65_RS08990	COG0488	(ABC) transporter
OPU65_RS08995	COG3153	acetyltransferase
OPU65_RS08995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OPU65_RS09000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OPU65_RS09005	COG0517	IMP dehydrogenase activity
OPU65_RS09015	COG0564	pseudouridine synthase activity
OPU65_RS09020	COG3764	Sortase (surface protein transpeptidase)
OPU65_RS09025	COG0737	Belongs to the 5'-nucleotidase family
OPU65_RS09025	COG1525	nuclease
OPU65_RS09025	COG4085	toxin activity
OPU65_RS09030	COG5002	protein histidine kinase activity
OPU65_RS09035	COG5577	PFAM Coat F domain
OPU65_RS09060	COG1823	symporter activity
OPU65_RS09065	COG1464	Belongs to the NlpA lipoprotein family
OPU65_RS09070	COG2011	ABC-type metal ion transport system permease component
OPU65_RS09075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OPU65_RS09080	COG1278	Cold shock
OPU65_RS09085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OPU65_RS09090	COG1131	(ABC) transporter
OPU65_RS09095	COG1131	(ABC) transporter
OPU65_RS09100	COG1725	Transcriptional regulator
OPU65_RS09115	COG0655	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS09120	COG2814	Major facilitator Superfamily
OPU65_RS09125	COG1566	PFAM secretion protein HlyD family protein
OPU65_RS09130	COG2718	Belongs to the UPF0229 family
OPU65_RS09135	COG2766	serine protein kinase
OPU65_RS09145	COG1664	Polymer-forming cytoskeletal
OPU65_RS09150	COG0789	Transcriptional regulator
OPU65_RS09155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OPU65_RS09165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OPU65_RS09170	COG3382	B3 4 domain protein
OPU65_RS09180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OPU65_RS09195	COG1121	(ABC) transporter
OPU65_RS09205	COG1476	TRANSCRIPTIONal
OPU65_RS09215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OPU65_RS09220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OPU65_RS09225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OPU65_RS09230	COG1116	anion transmembrane transporter activity
OPU65_RS09235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OPU65_RS09240	COG0710	3-dehydroquinate dehydratase activity
OPU65_RS09280	COG0457	Tetratricopeptide repeat
OPU65_RS09285	COG4974	Belongs to the 'phage' integrase family
OPU65_RS09405	COG0735	belongs to the Fur family
OPU65_RS09410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OPU65_RS09415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OPU65_RS09420	COG4129	membrane
OPU65_RS09425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS09430	COG0601	transmembrane transport
OPU65_RS09435	COG0747	negative chemotaxis
OPU65_RS09440	COG4608	Belongs to the ABC transporter superfamily
OPU65_RS09445	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS09450	COG1132	(ABC) transporter
OPU65_RS09455	COG3557	Belongs to the UPF0374 family
OPU65_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS09480	COG1194	a g-specific adenine glycosylase
OPU65_RS09485	COG1988	membrane-bound metal-dependent
OPU65_RS09490	COG4485	Bacterial membrane protein, YfhO
OPU65_RS09500	COG0463	Glycosyl transferase, family 2
OPU65_RS09525	COG2137	regulation of response to DNA damage stimulus
OPU65_RS09530	COG1090	epimerase
OPU65_RS09550	COG0778	Nitroreductase
OPU65_RS09555	COG0384	phenazine biosynthesis protein PhzF
OPU65_RS09560	COG0392	lysyltransferase activity
OPU65_RS09560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OPU65_RS09570	COG1051	belongs to the nudix hydrolase family
OPU65_RS09575	COG2249	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS09580	COG2514	catechol 2,3-dioxygenase activity
OPU65_RS09585	COG2259	Doxx family
OPU65_RS09590	COG1733	regulation of RNA biosynthetic process
OPU65_RS09605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS09605	COG1263	PTS System
OPU65_RS09610	COG1737	Transcriptional regulator
OPU65_RS09615	COG1486	melibiose metabolic process
OPU65_RS09625	COG3284	Transcriptional regulator
OPU65_RS09630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OPU65_RS09635	COG0508	dehydrogenase complex catalyzes the overall conversion of
OPU65_RS09640	COG0022	dehydrogenase e1 component
OPU65_RS09645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OPU65_RS09655	COG5609	conserved protein (DUF2294)
OPU65_RS09660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OPU65_RS09665	COG3002	Belongs to the UPF0753 family
OPU65_RS09670	COG0288	reversible hydration of carbon dioxide
OPU65_RS09675	COG3711	transcriptional antiterminator
OPU65_RS09680	COG1263	PTS System
OPU65_RS09680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS09690	COG0477	Major facilitator Superfamily
OPU65_RS09700	COG1819	glycosyl
OPU65_RS09725	COG4637	Psort location Cytoplasmic, score
OPU65_RS09730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OPU65_RS09735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OPU65_RS09740	COG0598	Magnesium transport protein CorA
OPU65_RS09750	COG0371	Dehydrogenase
OPU65_RS09755	COG0726	polysaccharide deacetylase
OPU65_RS09765	COG0535	radical SAM domain protein
OPU65_RS09775	COG0387	Pfam Sodium calcium exchanger
OPU65_RS09785	COG0477	Major facilitator Superfamily
OPU65_RS09790	COG1295	ribonuclease BN
OPU65_RS09795	COG4980	gas vesicle protein
OPU65_RS09800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OPU65_RS09805	COG1115	amino acid carrier protein
OPU65_RS09810	COG4840	Belongs to the UPF0435 family
OPU65_RS09820	COG0737	Belongs to the 5'-nucleotidase family
OPU65_RS09825	COG0778	Nitroreductase
OPU65_RS09830	COG1733	regulation of RNA biosynthetic process
OPU65_RS09845	COG0673	inositol 2-dehydrogenase activity
OPU65_RS09855	COG0463	Glycosyl transferase, family 2
OPU65_RS09855	COG0457	Tetratricopeptide repeat
OPU65_RS09860	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS09870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OPU65_RS09875	COG1045	serine acetyltransferase
OPU65_RS09880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OPU65_RS09895	COG2188	Transcriptional regulator
OPU65_RS09900	COG0366	Alpha amylase catalytic
OPU65_RS09905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS09905	COG1263	PTS System
OPU65_RS09910	COG1115	amino acid carrier protein
OPU65_RS09920	COG1368	sulfuric ester hydrolase activity
OPU65_RS09925	COG0024	Methionine aminopeptidase
OPU65_RS09940	COG2258	MOSC domain
OPU65_RS09945	COG1254	Belongs to the acylphosphatase family
OPU65_RS09950	COG0640	Transcriptional regulator
OPU65_RS09955	COG5658	integral membrane protein
OPU65_RS09965	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
OPU65_RS09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS09990	COG0471	metal ion transport
OPU65_RS10005	COG2130	NADP-dependent
OPU65_RS10010	COG0513	Belongs to the DEAD box helicase family
OPU65_RS10015	COG0488	(ABC) transporter
OPU65_RS10020	COG2814	Major facilitator Superfamily
OPU65_RS10025	COG0789	Transcriptional regulator
OPU65_RS10035	COG2124	cytochrome p450
OPU65_RS10040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OPU65_RS10045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OPU65_RS10050	COG0156	8-amino-7-oxononanoate synthase activity
OPU65_RS10055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OPU65_RS10060	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
OPU65_RS10065	COG0523	cobalamin synthesis protein
OPU65_RS10080	COG1469	GTP cyclohydrolase I activity
OPU65_RS10085	COG0640	Transcriptional regulator
OPU65_RS10095	COG0583	DNA-binding transcription factor activity
OPU65_RS10100	COG0488	(ABC) transporter
OPU65_RS10105	COG0471	metal ion transport
OPU65_RS10110	COG0840	transmembrane signaling receptor activity
OPU65_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS10140	COG0217	transcriptional regulatory protein
OPU65_RS10165	COG0457	Tetratricopeptide repeat
OPU65_RS10170	COG3711	transcriptional antiterminator
OPU65_RS10175	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS10180	COG1263	PTS System
OPU65_RS10180	COG2190	(PTS) system
OPU65_RS10180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS10220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OPU65_RS10225	COG1597	lipid kinase activity
OPU65_RS10230	COG1957	nucleoside hydrolase
OPU65_RS10235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OPU65_RS10245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OPU65_RS10250	COG1309	transcriptional regulator
OPU65_RS10255	COG4124	Belongs to the glycosyl hydrolase 26 family
OPU65_RS10270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OPU65_RS10275	COG0154	amidase activity
OPU65_RS10280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OPU65_RS10285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS10290	COG1285	pathogenesis
OPU65_RS10295	COG0363	glucosamine-6-phosphate deaminase activity
OPU65_RS10300	COG3457	Alanine racemase
OPU65_RS10305	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OPU65_RS10310	COG0626	cystathionine gamma-synthase activity
OPU65_RS10315	COG1735	metal-dependent hydrolase with the TIM-barrel fold
OPU65_RS10335	COG2188	Transcriptional regulator
OPU65_RS10340	COG4851	CamS sex pheromone cAM373 precursor
OPU65_RS10345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OPU65_RS10350	COG0210	DNA helicase
OPU65_RS10355	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
OPU65_RS10360	COG4496	protein, YerC YecD
OPU65_RS10365	COG1470	cell adhesion involved in biofilm formation
OPU65_RS10370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OPU65_RS10390	COG2124	cytochrome p450
OPU65_RS10400	COG0151	Belongs to the GarS family
OPU65_RS10405	COG0138	bifunctional purine biosynthesis protein purh
OPU65_RS10415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OPU65_RS10420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OPU65_RS10425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OPU65_RS10430	COG0047	phosphoribosylformylglycinamidine synthase activity
OPU65_RS10435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OPU65_RS10440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OPU65_RS10445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OPU65_RS10450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OPU65_RS10455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OPU65_RS10465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
OPU65_RS10480	COG2252	PERMEase
OPU65_RS10490	COG0789	Transcriptional regulator
OPU65_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS10500	COG0519	Catalyzes the synthesis of GMP from XMP
OPU65_RS10500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OPU65_RS10505	COG1305	Transglutaminase-like
OPU65_RS10510	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
OPU65_RS10515	COG0714	Associated with various cellular activities
OPU65_RS10520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OPU65_RS10540	COG2132	Multicopper oxidase
OPU65_RS10550	COG0702	epimerase
OPU65_RS10575	COG0823	Involved in the tonB-independent uptake of proteins
OPU65_RS10580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OPU65_RS10595	COG1846	Transcriptional regulator
OPU65_RS10600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OPU65_RS10610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OPU65_RS10615	COG0366	Alpha amylase catalytic
OPU65_RS10620	COG1554	hydrolase, family 65, central catalytic
OPU65_RS10625	COG5521	maltodextrose utilization protein MalA
OPU65_RS10630	COG3833	ABC-type maltose transport systems, permease component
OPU65_RS10635	COG1175	transmembrane transport
OPU65_RS10640	COG2182	Extracellular solute-binding protein
OPU65_RS10645	COG0366	Alpha amylase catalytic
OPU65_RS10650	COG1609	Transcriptional regulator
OPU65_RS10660	COG0726	polysaccharide deacetylase
OPU65_RS10685	COG0772	Belongs to the SEDS family
OPU65_RS10690	COG0772	Belongs to the SEDS family
OPU65_RS10695	COG3339	Conserved Protein
OPU65_RS10700	COG1280	lysine exporter protein (LysE YggA)
OPU65_RS10705	COG1378	Sugar-specific transcriptional regulator TrmB
OPU65_RS10715	COG4260	virion core protein, lumpy skin disease virus
OPU65_RS10720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OPU65_RS10725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OPU65_RS10730	COG1842	Phage shock protein A
OPU65_RS10735	COG2814	Major facilitator Superfamily
OPU65_RS10740	COG2272	Belongs to the type-B carboxylesterase lipase family
OPU65_RS10745	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
OPU65_RS10750	COG3189	MarR family transcriptional regulator
OPU65_RS10760	COG3848	Pyruvate phosphate dikinase
OPU65_RS10760	COG0574	Belongs to the PEP-utilizing enzyme family
OPU65_RS10765	COG1309	transcriptional regulator
OPU65_RS10775	COG2135	peptidase activity
OPU65_RS10795	COG2720	vancomycin resistance protein
OPU65_RS10830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OPU65_RS10890	COG5280	Phage tail tape measure protein TP901
OPU65_RS10890	COG3953	SLT domain
OPU65_RS10975	COG0582	viral genome integration into host DNA
OPU65_RS11100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OPU65_RS11105	COG4974	Belongs to the 'phage' integrase family
OPU65_RS11110	COG0459	protein refolding
OPU65_RS11115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OPU65_RS11120	COG1266	CAAX protease self-immunity
OPU65_RS11130	COG0805	protein transport
OPU65_RS11135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OPU65_RS11140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OPU65_RS11145	COG0315	cyclic pyranopterin monophosphate synthase activity
OPU65_RS11150	COG0488	(ABC) transporter
OPU65_RS11155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OPU65_RS11160	COG0456	acetyltransferase
OPU65_RS11165	COG1214	PFAM Peptidase M22, glycoprotease
OPU65_RS11170	COG0802	atpase or kinase
OPU65_RS11175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OPU65_RS11215	COG2814	Major facilitator Superfamily
OPU65_RS11220	COG3764	Sortase (surface protein transpeptidase)
OPU65_RS11230	COG3279	Response regulator of the LytR AlgR family
OPU65_RS11240	COG0745	RESPONSE REGULATOR receiver
OPU65_RS11240	COG2972	Histidine kinase
OPU65_RS11245	COG1979	alcohol dehydrogenase
OPU65_RS11250	COG2814	Major facilitator Superfamily
OPU65_RS11255	COG0494	nUDIX hydrolase
OPU65_RS11260	COG2755	lipolytic protein G-D-S-L family
OPU65_RS11260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OPU65_RS11270	COG1595	DNA-templated transcription, initiation
OPU65_RS11275	COG5566	PFAM Mor transcription activator
OPU65_RS11280	COG0596	Alpha beta hydrolase
OPU65_RS11295	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS11300	COG1113	amino acid transport
OPU65_RS11310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
OPU65_RS11320	COG3545	Serine hydrolase
OPU65_RS11345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS11350	COG1733	regulation of RNA biosynthetic process
OPU65_RS11360	COG2808	Putative FMN-binding domain
OPU65_RS11365	COG0456	acetyltransferase
OPU65_RS11370	COG1846	Transcriptional regulator
OPU65_RS11375	COG2364	Membrane
OPU65_RS11380	COG1136	(ABC) transporter
OPU65_RS11385	COG0577	efflux transmembrane transporter activity
OPU65_RS11400	COG0477	Major facilitator Superfamily
OPU65_RS11405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS11415	COG1278	Cold shock
OPU65_RS11420	COG3239	Fatty acid desaturase
OPU65_RS11425	COG0726	polysaccharide deacetylase
OPU65_RS11475	COG3091	SprT-like family
OPU65_RS11485	COG1033	growth of symbiont in host cell
OPU65_RS11485	COG2409	Drug exporters of the RND superfamily
OPU65_RS11495	COG1309	transcriptional regulator
OPU65_RS11500	COG2183	response to ionizing radiation
OPU65_RS11505	COG2208	phosphoserine phosphatase activity
OPU65_RS11510	COG1191	sigma factor activity
OPU65_RS11525	COG2208	phosphoserine phosphatase activity
OPU65_RS11530	COG2172	sigma factor antagonist activity
OPU65_RS11535	COG1366	Belongs to the anti-sigma-factor antagonist family
OPU65_RS11540	COG1366	Belongs to the anti-sigma-factor antagonist family
OPU65_RS11545	COG2337	Toxic component of a toxin-antitoxin (TA) module
OPU65_RS11550	COG0864	Transcriptional regulator
OPU65_RS11555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OPU65_RS11565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OPU65_RS11570	COG0705	Rhomboid family
OPU65_RS11575	COG3428	Bacterial PH domain
OPU65_RS11580	COG3402	PFAM membrane-flanked domain
OPU65_RS11585	COG0513	Belongs to the DEAD box helicase family
OPU65_RS11595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OPU65_RS11600	COG1181	Belongs to the D-alanine--D-alanine ligase family
OPU65_RS11605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS11620	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS11630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OPU65_RS11635	COG1131	(ABC) transporter
OPU65_RS11640	COG1301	dicarboxylic acid transport
OPU65_RS11645	COG0628	permease
OPU65_RS11655	COG0662	Cupin 2, conserved barrel domain protein
OPU65_RS11665	COG2217	Heavy metal translocating P-type atpase
OPU65_RS11670	COG4876	unkown
OPU65_RS11675	COG1819	glycosyl
OPU65_RS11680	COG1027	Aspartate ammonia-lyase
OPU65_RS11685	COG2261	transglycosylase associated protein
OPU65_RS11690	COG1914	H( )-stimulated, divalent metal cation uptake system
OPU65_RS11695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OPU65_RS11710	COG0028	Belongs to the TPP enzyme family
OPU65_RS11715	COG1605	Chorismate mutase
OPU65_RS11720	COG0512	Glutamine amidotransferase of anthranilate synthase
OPU65_RS11720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OPU65_RS11725	COG0287	Prephenate dehydrogenase
OPU65_RS11730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OPU65_RS11730	COG0551	DNA topoisomerase type I activity
OPU65_RS11735	COG1522	sequence-specific DNA binding
OPU65_RS11745	COG2814	Major facilitator Superfamily
OPU65_RS11760	COG3871	stress protein (general stress protein 26)
OPU65_RS11770	COG1917	Cupin 2, conserved barrel domain protein
OPU65_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS11780	COG3711	transcriptional antiterminator
OPU65_RS11785	COG0246	Mannitol dehydrogenase
OPU65_RS11790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS11795	COG2213	PTS system mannitol-specific
OPU65_RS11800	COG2755	lipolytic protein G-D-S-L family
OPU65_RS11805	COG1414	Transcriptional regulator
OPU65_RS11810	COG1984	allophanate hydrolase subunit 2
OPU65_RS11815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OPU65_RS11820	COG4336	lyase activity
OPU65_RS11825	COG1914	H( )-stimulated, divalent metal cation uptake system
OPU65_RS11830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OPU65_RS11835	COG0561	phosphatase activity
OPU65_RS11840	COG3958	Transketolase
OPU65_RS11845	COG3959	Transketolase, thiamine diphosphate binding domain
OPU65_RS11860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS11870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OPU65_RS11875	COG0471	metal ion transport
OPU65_RS11880	COG1802	Transcriptional regulator
OPU65_RS11885	COG1587	Uroporphyrinogen-III synthase
OPU65_RS11885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OPU65_RS11890	COG2146	nitrite reductase [NAD(P)H] activity
OPU65_RS11895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OPU65_RS11900	COG0243	molybdopterin cofactor binding
OPU65_RS11905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OPU65_RS11910	COG1349	DNA-binding transcription factor activity
OPU65_RS11915	COG1276	copper resistance
OPU65_RS11915	COG2372	response to copper ion
OPU65_RS11920	COG4549	nuclear export factor GLE1
OPU65_RS11935	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS11940	COG0531	amino acid
OPU65_RS11945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OPU65_RS11950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS11955	COG0640	Transcriptional regulator
OPU65_RS11960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OPU65_RS11965	COG0778	Nitroreductase
OPU65_RS11980	COG1309	transcriptional regulator
OPU65_RS11985	COG2814	Major facilitator Superfamily
OPU65_RS11990	COG4607	ABC-type enterochelin transport system periplasmic component
OPU65_RS11995	COG4604	ABC transporter, ATP-binding protein
OPU65_RS12000	COG4605	iron ion homeostasis
OPU65_RS12005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS12010	COG0527	aspartate kinase activity
OPU65_RS12015	COG0840	transmembrane signaling receptor activity
OPU65_RS12020	COG3850	Histidine kinase
OPU65_RS12020	COG5002	protein histidine kinase activity
OPU65_RS12025	COG0745	RESPONSE REGULATOR receiver
OPU65_RS12030	COG0577	efflux transmembrane transporter activity
OPU65_RS12035	COG1136	(ABC) transporter
OPU65_RS12040	COG0789	Transcriptional regulator
OPU65_RS12045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OPU65_RS12055	COG0697	spore germination
OPU65_RS12060	COG5434	Belongs to the glycosyl hydrolase 28 family
OPU65_RS12065	COG3104	oligopeptide transport
OPU65_RS12075	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
OPU65_RS12085	COG1874	Beta-galactosidase
OPU65_RS12090	COG0456	acetyltransferase
OPU65_RS12090	COG1846	Transcriptional regulator
OPU65_RS12095	COG2271	Major facilitator Superfamily
OPU65_RS12100	COG4214	carbohydrate transport
OPU65_RS12110	COG4213	ABC transporter substrate-binding protein
OPU65_RS12115	COG4753	response regulator
OPU65_RS12115	COG2207	Transcriptional regulator
OPU65_RS12120	COG2972	Histidine kinase
OPU65_RS12140	COG5444	nuclease activity
OPU65_RS12190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OPU65_RS12195	COG0163	prenyltransferase activity
OPU65_RS12200	COG0583	DNA-binding transcription factor activity
OPU65_RS12205	COG0010	Belongs to the arginase family
OPU65_RS12210	COG0833	amino acid
OPU65_RS12215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OPU65_RS12220	COG3829	transcription factor binding
OPU65_RS12225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OPU65_RS12230	COG0765	amino acid transport
OPU65_RS12235	COG1126	abc transporter atp-binding protein
OPU65_RS12275	COG2364	Membrane
OPU65_RS12280	COG2207	Transcriptional regulator
OPU65_RS12280	COG3708	Transcriptional regulator
OPU65_RS12285	COG2819	hydrolase of the alpha beta superfamily
OPU65_RS12295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS12300	COG0697	spore germination
OPU65_RS12305	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OPU65_RS12310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OPU65_RS12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OPU65_RS12320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OPU65_RS12325	COG1177	transmembrane transport
OPU65_RS12335	COG3842	ATPase activity
OPU65_RS12355	COG5444	nuclease activity
OPU65_RS12360	COG0840	transmembrane signaling receptor activity
OPU65_RS12360	COG3290	protein histidine kinase activity
OPU65_RS12365	COG0515	serine threonine protein kinase
OPU65_RS12375	COG3209	COG3209 Rhs family protein
OPU65_RS12385	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS12395	COG2249	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OPU65_RS12405	COG0765	amino acid transport
OPU65_RS12425	COG3458	cephalosporin-C deacetylase activity
OPU65_RS12430	COG0701	Predicted permease
OPU65_RS12435	COG3689	TIGRFAM TIGR03943 family protein
OPU65_RS12440	COG2508	Transcriptional regulator
OPU65_RS12445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS12450	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS12455	COG0506	proline dehydrogenase activity
OPU65_RS12465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OPU65_RS12470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OPU65_RS12475	COG1113	amino acid transport
OPU65_RS12480	COG1280	lysine exporter protein (LysE YggA)
OPU65_RS12490	COG0039	L-malate dehydrogenase activity
OPU65_RS12495	COG2223	nitrite transmembrane transporter activity
OPU65_RS12500	COG0789	Transcriptional regulator
OPU65_RS12510	COG0785	Cytochrome C biogenesis protein
OPU65_RS12515	COG3853	Toxic anion resistance protein (TelA)
OPU65_RS12535	COG0861	Integral membrane protein TerC family
OPU65_RS12540	COG2310	stress, protein
OPU65_RS12545	COG2310	stress, protein
OPU65_RS12550	COG2310	stress, protein
OPU65_RS12570	COG1309	transcriptional regulator
OPU65_RS12575	COG1131	(ABC) transporter
OPU65_RS12585	COG0791	NLP P60 protein
OPU65_RS12585	COG3883	PFAM NLP P60 protein
OPU65_RS12590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OPU65_RS12595	COG3773	Cell wall hydrolase
OPU65_RS12605	COG1595	DNA-templated transcription, initiation
OPU65_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS12620	COG3591	Belongs to the peptidase S1B family
OPU65_RS12635	COG3394	polysaccharide catabolic process
OPU65_RS12640	COG2188	Transcriptional regulator
OPU65_RS12645	COG1486	melibiose metabolic process
OPU65_RS12650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS12655	COG1447	Phosphotransferase system cellobiose-specific component IIA
OPU65_RS12660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS12665	COG0277	FAD linked oxidase domain protein
OPU65_RS12670	COG0247	lactate metabolic process
OPU65_RS12675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OPU65_RS12680	COG2261	transglycosylase associated protein
OPU65_RS12685	COG1164	Oligoendopeptidase f
OPU65_RS12695	COG0456	acetyltransferase
OPU65_RS12700	COG0252	asparaginase activity
OPU65_RS12710	COG1288	antiporter activity
OPU65_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS12730	COG1942	4-Oxalocrotonate Tautomerase
OPU65_RS12735	COG0583	DNA-binding transcription factor activity
OPU65_RS12760	COG1131	(ABC) transporter
OPU65_RS12765	COG1405	negative regulation of cell septum assembly
OPU65_RS12765	COG3012	SEC-C Motif Domain Protein
OPU65_RS12775	COG0697	spore germination
OPU65_RS12785	COG0789	Transcriptional regulator
OPU65_RS12805	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS12810	COG1846	Transcriptional regulator
OPU65_RS12815	COG3173	Aminoglycoside phosphotransferase
OPU65_RS12840	COG1131	(ABC) transporter
OPU65_RS12845	COG2205	protein histidine kinase activity
OPU65_RS12850	COG0745	RESPONSE REGULATOR receiver
OPU65_RS12870	COG2721	sulfolactate sulfo-lyase activity
OPU65_RS12875	COG2186	Transcriptional regulator
OPU65_RS12880	COG4948	Mandelate Racemase Muconate Lactonizing
OPU65_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS12895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OPU65_RS12905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OPU65_RS12910	COG3540	Alkaline phosphatase
OPU65_RS12935	COG0784	Response regulator, receiver
OPU65_RS12940	COG4191	Histidine kinase
OPU65_RS12945	COG2066	Belongs to the glutaminase family
OPU65_RS12950	COG1115	amino acid carrier protein
OPU65_RS12960	COG2205	protein histidine kinase activity
OPU65_RS12970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OPU65_RS12970	COG4451	ribulose bisphosphate carboxylase, small
OPU65_RS12975	COG2323	membrane
OPU65_RS12980	COG0789	Transcriptional regulator
OPU65_RS12985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS12985	COG1263	PTS System
OPU65_RS12995	COG2040	homocysteine
OPU65_RS13000	COG0833	amino acid
OPU65_RS13010	COG4257	antibiotic catabolic process
OPU65_RS13025	COG4213	ABC transporter substrate-binding protein
OPU65_RS13030	COG0840	transmembrane signaling receptor activity
OPU65_RS13035	COG0371	Dehydrogenase
OPU65_RS13065	COG1917	Cupin 2, conserved barrel domain protein
OPU65_RS13065	COG2207	Transcriptional regulator
OPU65_RS13070	COG0697	spore germination
OPU65_RS13080	COG3409	Peptidoglycan-binding domain 1 protein
OPU65_RS13095	COG4682	membrane
OPU65_RS13100	COG1283	sodium-dependent phosphate transmembrane transporter activity
OPU65_RS13115	COG0730	response to heat
OPU65_RS13120	COG1802	Transcriptional regulator
OPU65_RS13125	COG0778	Nitroreductase
OPU65_RS13130	COG2226	methyltransferase
OPU65_RS13155	COG0789	Transcriptional regulator
OPU65_RS13160	COG0697	spore germination
OPU65_RS13165	COG1331	Highly conserved protein containing a thioredoxin domain
OPU65_RS13190	COG1011	Hydrolase
OPU65_RS13215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OPU65_RS13220	COG1132	(ABC) transporter
OPU65_RS13230	COG2814	Major facilitator Superfamily
OPU65_RS13235	COG0640	Transcriptional regulator
OPU65_RS13245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OPU65_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OPU65_RS13255	COG4856	YbbR-like protein
OPU65_RS13260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OPU65_RS13265	COG5662	AntiSigma factor
OPU65_RS13270	COG1595	DNA-templated transcription, initiation
OPU65_RS13305	COG1683	Conserved Protein
OPU65_RS13310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OPU65_RS13315	COG1737	Transcriptional regulator
OPU65_RS13320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS13320	COG1263	PTS System
OPU65_RS13325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OPU65_RS13330	COG1472	Belongs to the glycosyl hydrolase 3 family
OPU65_RS13335	COG3876	Protein conserved in bacteria
OPU65_RS13350	COG0385	Bile acid
OPU65_RS13360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OPU65_RS13390	COG0726	polysaccharide deacetylase
OPU65_RS13395	COG2194	sulfuric ester hydrolase activity
OPU65_RS13405	COG0489	protein tyrosine kinase activity
OPU65_RS13410	COG0860	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS13425	COG2318	DinB family
OPU65_RS13580	COG1783	phage Terminase large subunit
OPU65_RS13585	COG5484	DNA packaging
OPU65_RS13665	COG0629	single-stranded DNA binding
OPU65_RS13675	COG3331	DNA recombination
OPU65_RS13725	COG1484	DNA-dependent DNA replication
OPU65_RS13810	COG3620	sequence-specific DNA binding
OPU65_RS13825	COG2856	Zn peptidase
OPU65_RS13830	COG0582	viral genome integration into host DNA
OPU65_RS13835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OPU65_RS13840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OPU65_RS13845	COG0101	tRNA pseudouridine synthase activity
OPU65_RS13850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OPU65_RS13855	COG1122	ATPase activity
OPU65_RS13860	COG1122	ATPase activity
OPU65_RS13865	COG0203	ribosomal protein L17
OPU65_RS13870	COG0202	RNA polymerase activity
OPU65_RS13875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OPU65_RS13880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OPU65_RS13885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OPU65_RS13890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OPU65_RS13895	COG2163	COG2163 Ribosomal protein L14E L6E L27E
OPU65_RS13900	COG0024	Methionine aminopeptidase
OPU65_RS13905	COG0563	adenylate kinase activity
OPU65_RS13910	COG0201	protein transport
OPU65_RS13915	COG0200	Binds to the 23S rRNA
OPU65_RS13920	COG1841	ribosomal large subunit assembly
OPU65_RS13925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OPU65_RS13930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OPU65_RS13935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OPU65_RS13940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OPU65_RS13945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OPU65_RS13950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OPU65_RS13955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OPU65_RS13960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OPU65_RS13965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OPU65_RS13970	COG0255	Belongs to the universal ribosomal protein uL29 family
OPU65_RS13975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OPU65_RS13980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OPU65_RS13985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OPU65_RS13990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OPU65_RS14000	COG0089	rRNA binding
OPU65_RS14005	COG0088	Forms part of the polypeptide exit tunnel
OPU65_RS14010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OPU65_RS14020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OPU65_RS14025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OPU65_RS14030	COG0049	tRNA binding
OPU65_RS14035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OPU65_RS14040	COG1358	cellular component organization or biogenesis
OPU65_RS14045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OPU65_RS14050	COG0085	RNA polymerase activity
OPU65_RS14055	COG2813	Specifically methylates the guanine in position
OPU65_RS14060	COG0222	ribosome binding
OPU65_RS14065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OPU65_RS14070	COG0081	regulation of translation
OPU65_RS14075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OPU65_RS14080	COG0250	Participates in transcription elongation, termination and antitermination
OPU65_RS14090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OPU65_RS14100	COG3688	RNA-binding protein containing a PIN domain
OPU65_RS14105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OPU65_RS14115	COG0215	cysteine-tRNA ligase activity
OPU65_RS14120	COG1045	serine acetyltransferase
OPU65_RS14125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OPU65_RS14130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OPU65_RS14135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OPU65_RS14140	COG4956	integral membrane protein (PIN domain superfamily)
OPU65_RS14145	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
OPU65_RS14150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OPU65_RS14155	COG0542	response to heat
OPU65_RS14160	COG3869	Catalyzes the specific phosphorylation of arginine residues in
OPU65_RS14165	COG3880	PFAM UvrB UvrC protein
OPU65_RS14170	COG4463	regulation of RNA biosynthetic process
OPU65_RS14250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OPU65_RS14255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OPU65_RS14260	COG1396	sequence-specific DNA binding
OPU65_RS14265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OPU65_RS14270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OPU65_RS14275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OPU65_RS14280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OPU65_RS14285	COG0512	Glutamine amidotransferase of anthranilate synthase
OPU65_RS14290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OPU65_RS14295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OPU65_RS14300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OPU65_RS14305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OPU65_RS14310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OPU65_RS14315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OPU65_RS14320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OPU65_RS14325	COG0037	tRNA processing
OPU65_RS14330	COG0515	serine threonine protein kinase
OPU65_RS14335	COG2304	oxidoreductase activity
OPU65_RS14340	COG2208	phosphoserine phosphatase activity
OPU65_RS14355	COG1098	S1 RNA binding domain
OPU65_RS14360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OPU65_RS14375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OPU65_RS14380	COG3956	TIGRFAM MazG family protein
OPU65_RS14385	COG2244	polysaccharide biosynthetic process
OPU65_RS14390	COG2002	toxin-antitoxin pair type II binding
OPU65_RS14395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OPU65_RS14405	COG0193	aminoacyl-tRNA hydrolase activity
OPU65_RS14410	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OPU65_RS14415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OPU65_RS14420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OPU65_RS14425	COG2088	sporulation resulting in formation of a cellular spore
OPU65_RS14430	COG0251	oxidation-reduction process
OPU65_RS14435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OPU65_RS14440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OPU65_RS14450	COG4466	Protein conserved in bacteria
OPU65_RS14460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OPU65_RS14465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
OPU65_RS14470	COG3584	3D domain protein
OPU65_RS14470	COG3583	domain protein
OPU65_RS14475	COG0084	hydrolase, TatD family'
OPU65_RS14480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OPU65_RS14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OPU65_RS14485	COG2002	toxin-antitoxin pair type II binding
OPU65_RS14490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OPU65_RS14495	COG2827	Endonuclease containing a URI domain
OPU65_RS14500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OPU65_RS14505	COG4467	Involved in initiation control of chromosome replication
OPU65_RS14510	COG1774	PSP1 C-terminal conserved region
OPU65_RS14515	COG0470	DNA polymerase III
OPU65_RS14520	COG1728	Protein conserved in bacteria
OPU65_RS14525	COG3870	Protein conserved in bacteria
OPU65_RS14530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OPU65_RS14535	COG1982	Orn Lys Arg decarboxylase major
OPU65_RS14540	COG3853	Toxic anion resistance protein (TelA)
OPU65_RS14545	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
OPU65_RS14590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OPU65_RS14595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OPU65_RS14600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OPU65_RS14610	COG0590	tRNA wobble adenosine to inosine editing
OPU65_RS14615	COG1335	isochorismatase
OPU65_RS14620	COG1388	LysM domain
OPU65_RS14620	COG3858	chitin binding
OPU65_RS14625	COG1428	Deoxynucleoside kinase
OPU65_RS14630	COG1428	Deoxynucleoside kinase
OPU65_RS14650	COG3835	regulator
OPU65_RS14660	COG1929	Belongs to the glycerate kinase type-1 family
OPU65_RS14665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OPU65_RS14670	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OPU65_RS14675	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
OPU65_RS14680	COG1686	Belongs to the peptidase S11 family
OPU65_RS14685	COG0516	GMP reductase activity
OPU65_RS14685	COG0517	IMP dehydrogenase activity
OPU65_RS14720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OPU65_RS14725	COG0187	DNA topoisomerase II activity
OPU65_RS14735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OPU65_RS14740	COG2501	S4 domain
OPU65_RS14745	COG0592	DNA-directed DNA polymerase activity
OPU65_RS14750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OPU65_RS14760	COG0594	ribonuclease P activity
OPU65_RS14765	COG0706	membrane insertase activity
OPU65_RS14770	COG1847	R3H domain protein
OPU65_RS14775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OPU65_RS14780	COG0445	tRNA wobble uridine modification
OPU65_RS14785	COG0357	Ribosomal RNA small subunit methyltransferase G
OPU65_RS14790	COG1475	DNA binding
OPU65_RS14795	COG1595	DNA-templated transcription, initiation
OPU65_RS14800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OPU65_RS14805	COG1192	Involved in chromosome partitioning
OPU65_RS14810	COG1475	DNA binding
OPU65_RS14820	COG3949	Membrane
OPU65_RS14825	COG4481	Protein conserved in bacteria
OPU65_RS14830	COG0012	GTP binding
OPU65_RS14835	COG0360	Binds together with S18 to 16S ribosomal RNA
OPU65_RS14840	COG0629	single-stranded DNA binding
OPU65_RS14845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OPU65_RS14850	COG2271	Major facilitator Superfamily
OPU65_RS14855	COG0659	secondary active sulfate transmembrane transporter activity
OPU65_RS14860	COG0589	response to stress
OPU65_RS14865	COG5577	PFAM Coat F domain
OPU65_RS14875	COG4241	membrane
OPU65_RS14880	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
OPU65_RS14885	COG0359	binds to the 23S rRNA
OPU65_RS14890	COG1263	PTS System
OPU65_RS14890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS14895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OPU65_RS14900	COG2188	Transcriptional regulator
OPU65_RS14905	COG0363	glucosamine-6-phosphate deaminase activity
OPU65_RS14910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OPU65_RS14915	COG2807	transmembrane transport
OPU65_RS14920	COG3093	addiction module antidote protein HigA
OPU65_RS14935	COG0305	Participates in initiation and elongation during chromosome replication
OPU65_RS14945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OPU65_RS14950	COG1051	belongs to the nudix hydrolase family
OPU65_RS14975	COG0745	RESPONSE REGULATOR receiver
OPU65_RS14980	COG5002	protein histidine kinase activity
OPU65_RS14985	COG4863	YycH protein
OPU65_RS14990	COG4853	Protein conserved in bacteria
OPU65_RS14995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OPU65_RS15000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OPU65_RS15015	COG0456	acetyltransferase
OPU65_RS15030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OPU65_RS15085	COG2197	response regulator
OPU65_RS15090	COG4585	Histidine kinase
OPU65_RS15095	COG0842	Transport permease protein
OPU65_RS15100	COG1131	(ABC) transporter
OPU65_RS15110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS15115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS15120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS15140	COG1113	amino acid transport
OPU65_RS15150	COG3634	alkyl hydroperoxide reductase activity
OPU65_RS15155	COG0450	alkyl hydroperoxide reductase
OPU65_RS15160	COG0038	chloride channel
OPU65_RS15165	COG2323	membrane
OPU65_RS15170	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS15170	COG1454	alcohol dehydrogenase
OPU65_RS15205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OPU65_RS15215	COG1940	carbohydrate kinase activity
OPU65_RS15220	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OPU65_RS15225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OPU65_RS15235	COG1609	Transcriptional regulator
OPU65_RS15240	COG2182	Extracellular solute-binding protein
OPU65_RS15245	COG1175	transmembrane transport
OPU65_RS15250	COG3833	ABC-type maltose transport systems, permease component
OPU65_RS15255	COG1874	Beta-galactosidase
OPU65_RS15260	COG3867	Arabinogalactan endo-beta-1,4-galactanase
OPU65_RS15265	COG0686	Belongs to the AlaDH PNT family
OPU65_RS15270	COG1115	amino acid carrier protein
OPU65_RS15275	COG5278	phosphoserine phosphatase activity
OPU65_RS15275	COG0840	transmembrane signaling receptor activity
OPU65_RS15285	COG0745	RESPONSE REGULATOR receiver
OPU65_RS15290	COG2205	protein histidine kinase activity
OPU65_RS15295	COG1136	(ABC) transporter
OPU65_RS15300	COG0577	efflux transmembrane transporter activity
OPU65_RS15305	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
OPU65_RS15335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS15355	COG0561	phosphatase activity
OPU65_RS15360	COG0488	(ABC) transporter
OPU65_RS15365	COG0326	Molecular chaperone. Has ATPase activity
OPU65_RS15370	COG2271	Major facilitator Superfamily
OPU65_RS15375	COG0584	glycerophosphoryl diester phosphodiesterase
OPU65_RS15380	COG0667	Aldo Keto reductase
OPU65_RS15385	COG1349	DNA-binding transcription factor activity
OPU65_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS15395	COG3718	enzyme involved in inositol metabolism
OPU65_RS15400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OPU65_RS15405	COG3962	Belongs to the TPP enzyme family
OPU65_RS15410	COG1082	Xylose isomerase domain protein TIM barrel
OPU65_RS15415	COG2814	Major facilitator Superfamily
OPU65_RS15420	COG0673	inositol 2-dehydrogenase activity
OPU65_RS15425	COG1082	Xylose isomerase domain protein TIM barrel
OPU65_RS15430	COG1082	Xylose isomerase domain protein TIM barrel
OPU65_RS15435	COG0191	fructose-bisphosphate aldolase activity
OPU65_RS15445	COG1181	Belongs to the D-alanine--D-alanine ligase family
OPU65_RS15460	COG3977	Valine--pyruvate aminotransferase
OPU65_RS15470	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS15475	COG5298	Protein conserved in bacteria
OPU65_RS15480	COG3706	GGDEF domain
OPU65_RS15485	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OPU65_RS15495	COG2390	Transcriptional regulator
OPU65_RS15500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OPU65_RS15505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OPU65_RS15510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OPU65_RS15550	COG0513	Belongs to the DEAD box helicase family
OPU65_RS15560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OPU65_RS15565	COG3842	ATPase activity
OPU65_RS15570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
OPU65_RS15580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS15580	COG1263	PTS System
OPU65_RS15580	COG2190	(PTS) system
OPU65_RS15585	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS15590	COG0745	RESPONSE REGULATOR receiver
OPU65_RS15595	COG2205	protein histidine kinase activity
OPU65_RS15600	COG1136	(ABC) transporter
OPU65_RS15605	COG0577	efflux transmembrane transporter activity
OPU65_RS15610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OPU65_RS15620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OPU65_RS15625	COG2224	Isocitrate lyase
OPU65_RS15635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OPU65_RS15640	COG4721	ABC-type cobalt transport system, permease component
OPU65_RS15645	COG1122	ATPase activity
OPU65_RS15650	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OPU65_RS15655	COG3711	transcriptional antiterminator
OPU65_RS15660	COG1263	PTS System
OPU65_RS15660	COG2190	(PTS) system
OPU65_RS15660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS15665	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS15675	COG0753	catalase activity
OPU65_RS15675	COG0693	protein deglycase activity
OPU65_RS15680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OPU65_RS15715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OPU65_RS15720	COG0463	Glycosyl transferase, family 2
OPU65_RS15725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OPU65_RS15730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OPU65_RS15750	COG1609	Transcriptional regulator
OPU65_RS15760	COG1175	transmembrane transport
OPU65_RS15765	COG0395	ABC-type sugar transport system, permease component
OPU65_RS15770	COG2223	nitrite transmembrane transporter activity
OPU65_RS15775	COG1621	beta-fructofuranosidase activity
OPU65_RS15780	COG2195	Cleaves the N-terminal amino acid of tripeptides
OPU65_RS15790	COG1595	DNA-templated transcription, initiation
OPU65_RS15800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS15805	COG2723	6-phospho-beta-galactosidase activity
OPU65_RS15815	COG0549	Belongs to the carbamate kinase family
OPU65_RS15825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OPU65_RS15830	COG2235	arginine
OPU65_RS15840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS15850	COG1368	sulfuric ester hydrolase activity
OPU65_RS15865	COG0584	glycerophosphoryl diester phosphodiesterase
OPU65_RS15870	COG3493	citrate carrier protein
OPU65_RS15875	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS15885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS15890	COG0726	polysaccharide deacetylase
OPU65_RS15905	COG2706	6-phosphogluconolactonase activity
OPU65_RS15910	COG1396	sequence-specific DNA binding
OPU65_RS15915	COG0252	asparaginase activity
OPU65_RS15920	COG1027	Aspartate ammonia-lyase
OPU65_RS15925	COG1757	Na H antiporter
OPU65_RS15930	COG0281	malic enzyme
OPU65_RS15940	COG2116	formate transmembrane transporter activity
OPU65_RS15950	COG1271	oxidase subunit
OPU65_RS15955	COG1294	oxidase, subunit
OPU65_RS15960	COG4988	ABC transporter
OPU65_RS15965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OPU65_RS15970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OPU65_RS15980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OPU65_RS15985	COG0735	belongs to the Fur family
OPU65_RS15990	COG0753	catalase activity
OPU65_RS15995	COG0753	catalase activity
OPU65_RS16005	COG2814	Major facilitator Superfamily
OPU65_RS16010	COG1595	DNA-templated transcription, initiation
OPU65_RS16030	COG1131	(ABC) transporter
OPU65_RS16035	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OPU65_RS16055	COG2755	lipolytic protein G-D-S-L family
OPU65_RS16060	COG1132	(ABC) transporter
OPU65_RS16075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OPU65_RS16080	COG2079	MmgE PrpD family protein
OPU65_RS16085	COG0372	Belongs to the citrate synthase family
OPU65_RS16095	COG2094	Belongs to the DNA glycosylase MPG family
OPU65_RS16105	COG3711	transcriptional antiterminator
OPU65_RS16105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS16110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS16115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OPU65_RS16120	COG1447	Phosphotransferase system cellobiose-specific component IIA
OPU65_RS16125	COG1486	melibiose metabolic process
OPU65_RS16130	COG2814	Major facilitator Superfamily
OPU65_RS16135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OPU65_RS16140	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
OPU65_RS16145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OPU65_RS16150	COG1696	Membrane protein involved in D-alanine export
OPU65_RS16155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OPU65_RS16170	COG2357	RelA SpoT domain protein
OPU65_RS16185	COG0477	Major facilitator Superfamily
OPU65_RS16190	COG2234	aminopeptidase activity
OPU65_RS16200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OPU65_RS16205	COG0800	Aldolase
OPU65_RS16215	COG2271	Major facilitator Superfamily
OPU65_RS16220	COG5522	Integral membrane protein (intg_mem_TP0381)
OPU65_RS16225	COG1442	glycosyl transferase family 8
OPU65_RS16230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OPU65_RS16235	COG0346	lactoylglutathione lyase activity
OPU65_RS16240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OPU65_RS16245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS16250	COG1346	cytolysis
OPU65_RS16255	COG1380	Effector of murein hydrolase LrgA
OPU65_RS16270	COG0583	DNA-binding transcription factor activity
OPU65_RS16275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
OPU65_RS16280	COG0352	thiamine-phosphate diphosphorylase activity
OPU65_RS16285	COG1940	carbohydrate kinase activity
OPU65_RS16290	COG2115	Belongs to the xylose isomerase family
OPU65_RS16295	COG1070	Carbohydrate kinase
OPU65_RS16300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OPU65_RS16305	COG3162	membrane
OPU65_RS16310	COG0655	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS16320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OPU65_RS16325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OPU65_RS16330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OPU65_RS16340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OPU65_RS16380	COG0456	acetyltransferase
OPU65_RS16395	COG3314	Sporulation integral membrane protein YlbJ
OPU65_RS16400	COG0772	Belongs to the SEDS family
OPU65_RS16405	COG0772	Belongs to the SEDS family
OPU65_RS16410	COG1473	amidohydrolase
OPU65_RS16415	COG1404	Belongs to the peptidase S8 family
OPU65_RS16435	COG0778	Nitroreductase
OPU65_RS16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OPU65_RS16455	COG1404	Belongs to the peptidase S8 family
OPU65_RS16465	COG3711	transcriptional antiterminator
OPU65_RS16470	COG1263	PTS System
OPU65_RS16470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS16475	COG1621	beta-fructofuranosidase activity
OPU65_RS16485	COG0351	phosphomethylpyrimidine kinase
OPU65_RS16490	COG1216	Glycosyl transferase, family 2
OPU65_RS16495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OPU65_RS16500	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS16510	COG2233	PERMEase
OPU65_RS16515	COG2363	Small membrane protein
OPU65_RS16530	COG1131	(ABC) transporter
OPU65_RS16555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OPU65_RS16565	COG3253	May function as heme-dependent peroxidase
OPU65_RS16570	COG0280	phosphate acetyltransferase
OPU65_RS16580	COG1414	Transcriptional regulator
OPU65_RS16605	COG2814	Major facilitator Superfamily
OPU65_RS16630	COG4844	belongs to the
OPU65_RS16635	COG1078	dGTPase activity
OPU65_RS16640	COG3465	dGTPase activity
OPU65_RS16650	COG1942	4-Oxalocrotonate Tautomerase
OPU65_RS16655	COG1994	Peptidase M50
OPU65_RS16665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OPU65_RS16670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OPU65_RS16675	COG0010	Belongs to the arginase family
OPU65_RS16680	COG4506	Protein conserved in bacteria
OPU65_RS16685	COG0018	arginyl-trna synthetase
OPU65_RS16695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OPU65_RS16700	COG2181	nitrate reductase activity
OPU65_RS16700	COG0247	lactate metabolic process
OPU65_RS16705	COG0183	Belongs to the thiolase family
OPU65_RS16710	COG1250	3-hydroxyacyl-CoA dehydrogenase
OPU65_RS16715	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS16720	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS16725	COG3343	RNA polymerase activity
OPU65_RS16730	COG0504	CTP synthase activity
OPU65_RS16735	COG4821	SIS domain
OPU65_RS16740	COG2204	response regulator
OPU65_RS16745	COG0191	fructose-bisphosphate aldolase activity
OPU65_RS16750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OPU65_RS16755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OPU65_RS16760	COG1494	fructose-1,6-bisphosphatase
OPU65_RS16765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OPU65_RS16770	COG0254	rRNA binding
OPU65_RS16775	COG1435	thymidine kinase activity
OPU65_RS16780	COG0281	malic enzyme
OPU65_RS16785	COG0679	Auxin Efflux Carrier
OPU65_RS16790	COG0789	Transcriptional regulator
OPU65_RS16795	COG0346	lactoylglutathione lyase activity
OPU65_RS16800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OPU65_RS16805	COG2890	protein-(glutamine-N5) methyltransferase activity
OPU65_RS16815	COG1609	Transcriptional regulator
OPU65_RS16820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OPU65_RS16825	COG0561	phosphatase activity
OPU65_RS16830	COG0673	inositol 2-dehydrogenase activity
OPU65_RS16835	COG0738	Major facilitator superfamily
OPU65_RS16845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OPU65_RS16850	COG0009	L-threonylcarbamoyladenylate synthase
OPU65_RS16855	COG1971	Probably functions as a manganese efflux pump
OPU65_RS16860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OPU65_RS16865	COG0698	ribose 5-phosphate isomerase
OPU65_RS16870	COG4475	Protein of unknown function (DUF436)
OPU65_RS16875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OPU65_RS16880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OPU65_RS16900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OPU65_RS16905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OPU65_RS16910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OPU65_RS16915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OPU65_RS16920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OPU65_RS16925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OPU65_RS16930	COG4836	Membrane
OPU65_RS16940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OPU65_RS16945	COG2385	sporulation resulting in formation of a cellular spore
OPU65_RS16950	COG2304	oxidoreductase activity
OPU65_RS16955	COG2304	oxidoreductase activity
OPU65_RS16960	COG3383	formate dehydrogenase (NAD+) activity
OPU65_RS16965	COG2223	nitrite transmembrane transporter activity
OPU65_RS16970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OPU65_RS16975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OPU65_RS16980	COG1994	Peptidase M50
OPU65_RS16990	COG1959	2 iron, 2 sulfur cluster binding
OPU65_RS17000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OPU65_RS17010	COG2207	Transcriptional regulator
OPU65_RS17010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS17015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS17020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS17025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS17030	COG2819	hydrolase of the alpha beta superfamily
OPU65_RS17035	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS17040	COG1169	isochorismate synthase
OPU65_RS17045	COG1021	2,3-dihydroxybenzoate-AMP ligase
OPU65_RS17050	COG1535	isochorismatase
OPU65_RS17050	COG3433	isochorismatase activity
OPU65_RS17055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OPU65_RS17060	COG3251	PFAM MbtH domain protein
OPU65_RS17065	COG0477	Major facilitator Superfamily
OPU65_RS17070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OPU65_RS17080	COG1247	-acetyltransferase
OPU65_RS17085	COG0739	heme binding
OPU65_RS17095	COG0740	serine-type endopeptidase activity
OPU65_RS17100	COG0347	Belongs to the P(II) protein family
OPU65_RS17105	COG0004	ammonium transporteR
OPU65_RS17110	COG1253	flavin adenine dinucleotide binding
OPU65_RS17115	COG0598	Magnesium transport protein CorA
OPU65_RS17125	COG3361	conserved protein (COG2071)
OPU65_RS17130	COG3546	catalase activity
OPU65_RS17135	COG1227	inorganic diphosphatase activity
OPU65_RS17140	COG0671	phosphoesterase, PA-phosphatase related
OPU65_RS17145	COG2814	Major facilitator Superfamily
OPU65_RS17150	COG1846	Transcriptional regulator
OPU65_RS17155	COG1609	Transcriptional regulator
OPU65_RS17160	COG1077	Cell shape determining protein MreB Mrl
OPU65_RS17165	COG4786	Flagellar basal body rod
OPU65_RS17170	COG4786	Flagellar basal body rod
OPU65_RS17175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OPU65_RS17180	COG1970	mechanosensitive ion channel activity
OPU65_RS17195	COG0629	single-stranded DNA binding
OPU65_RS17215	COG3732	PTS system glucitol sorbitol-specific
OPU65_RS17225	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS17235	COG1349	DNA-binding transcription factor activity
OPU65_RS17240	COG0561	phosphatase activity
OPU65_RS17245	COG3878	Protein conserved in bacteria
OPU65_RS17250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OPU65_RS17255	COG4715	Zinc finger, swim domain protein
OPU65_RS17265	COG3944	biosynthesis protein
OPU65_RS17270	COG4464	protein tyrosine phosphatase activity
OPU65_RS17275	COG2059	Chromate
OPU65_RS17280	COG2059	Chromate
OPU65_RS17285	COG1522	sequence-specific DNA binding
OPU65_RS17290	COG0405	Gamma-glutamyltransferase
OPU65_RS17295	COG0583	DNA-binding transcription factor activity
OPU65_RS17300	COG0028	Belongs to the TPP enzyme family
OPU65_RS17305	COG3527	Alpha-acetolactate decarboxylase
OPU65_RS17310	COG2226	methyltransferase
OPU65_RS17320	COG1879	ABC-type sugar transport system periplasmic component
OPU65_RS17325	COG1172	Belongs to the binding-protein-dependent transport system permease family
OPU65_RS17330	COG1129	ABC transporter
OPU65_RS17335	COG1869	D-ribose catabolic process
OPU65_RS17340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OPU65_RS17345	COG1609	Transcriptional regulator
OPU65_RS17350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OPU65_RS17360	COG2843	Capsule synthesis protein
OPU65_RS17370	COG0791	NLP P60 protein
OPU65_RS17375	COG0561	phosphatase activity
OPU65_RS17380	COG1316	TRANSCRIPTIONal
OPU65_RS17385	COG2814	Major facilitator Superfamily
OPU65_RS17395	COG1063	alcohol dehydrogenase
OPU65_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS17405	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OPU65_RS17410	COG1609	Transcriptional regulator
OPU65_RS17415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OPU65_RS17420	COG0800	Aldolase
OPU65_RS17430	COG1328	CTP reductase activity
OPU65_RS17440	COG1482	cell wall glycoprotein biosynthetic process
OPU65_RS17445	COG4193	domain, Protein
OPU65_RS17455	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS17480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OPU65_RS17485	COG4193	domain, Protein
OPU65_RS17490	COG1134	teichoic acid transport
OPU65_RS17495	COG1682	transport, permease protein
OPU65_RS17500	COG0463	Glycosyl transferase, family 2
OPU65_RS17500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OPU65_RS17505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OPU65_RS17510	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS17515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OPU65_RS17520	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
OPU65_RS17525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OPU65_RS17530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OPU65_RS17535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OPU65_RS17540	COG1316	TRANSCRIPTIONal
OPU65_RS17555	COG2247	cell wall binding repeat
OPU65_RS17555	COG0860	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS17565	COG2244	polysaccharide biosynthetic process
OPU65_RS17570	COG0297	glycogen (starch) synthase activity
OPU65_RS17570	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS17575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OPU65_RS17580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OPU65_RS17585	COG3307	-O-antigen
OPU65_RS17590	COG3206	protein involved in exopolysaccharide biosynthesis
OPU65_RS17595	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS17600	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS17605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OPU65_RS17620	COG1739	Uncharacterized protein family UPF0029
OPU65_RS17625	COG4585	Histidine kinase
OPU65_RS17630	COG2197	response regulator
OPU65_RS17635	COG1307	EDD domain protein, DegV family
OPU65_RS17640	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OPU65_RS17650	COG1040	competence protein
OPU65_RS17660	COG2747	anti-sigma28 factor FlgM
OPU65_RS17665	COG3418	PFAM FlgN family protein
OPU65_RS17670	COG1256	bacterial-type flagellum assembly
OPU65_RS17670	COG4786	Flagellar basal body rod
OPU65_RS17675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OPU65_RS17685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
OPU65_RS17690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OPU65_RS17695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OPU65_RS17700	COG1334	flagellar protein FlaG
OPU65_RS17705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OPU65_RS17710	COG1516	flagellar protein fliS
OPU65_RS17725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OPU65_RS17730	COG0653	protein targeting
OPU65_RS17740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OPU65_RS17745	COG2010	Cytochrome c
OPU65_RS17750	COG2884	Cell division ATP-binding protein ftsE
OPU65_RS17755	COG2177	Part of the ABC transporter FtsEX involved in
OPU65_RS17760	COG3883	PFAM NLP P60 protein
OPU65_RS17760	COG0791	NLP P60 protein
OPU65_RS17765	COG3279	Response regulator of the LytR AlgR family
OPU65_RS17780	COG0473	3-isopropylmalate dehydrogenase activity
OPU65_RS17785	COG0793	Belongs to the peptidase S41A family
OPU65_RS17785	COG3409	Peptidoglycan-binding domain 1 protein
OPU65_RS17795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OPU65_RS17805	COG4897	Protein conserved in bacteria
OPU65_RS17810	COG0556	nucleotide-excision repair
OPU65_RS17815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OPU65_RS17835	COG3595	metallopeptidase activity
OPU65_RS17840	COG1983	PspC domain protein
OPU65_RS17845	COG1950	PFAM Membrane protein of
OPU65_RS17850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OPU65_RS17855	COG2814	Major facilitator Superfamily
OPU65_RS17860	COG1846	Transcriptional regulator
OPU65_RS17865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OPU65_RS17870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OPU65_RS17875	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OPU65_RS17880	COG0546	phosphoglycolate phosphatase activity
OPU65_RS17885	COG0110	maltose O-acetyltransferase activity
OPU65_RS17890	COG5297	Belongs to the glycosyl hydrolase family 6
OPU65_RS17895	COG4990	cell redox homeostasis
OPU65_RS17900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OPU65_RS17905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OPU65_RS17910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OPU65_RS17915	COG0131	Imidazoleglycerol-phosphate dehydratase
OPU65_RS17920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OPU65_RS17925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OPU65_RS17930	COG0107	imidazoleglycerol-phosphate synthase activity
OPU65_RS17935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OPU65_RS17935	COG0140	phosphoribosyl-ATP diphosphatase activity
OPU65_RS17940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OPU65_RS17945	COG0457	Tetratricopeptide repeat
OPU65_RS17950	COG0492	ferredoxin-NADP+ reductase activity
OPU65_RS17955	COG1051	belongs to the nudix hydrolase family
OPU65_RS17960	COG1660	Displays ATPase and GTPase activities
OPU65_RS17965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OPU65_RS17970	COG1481	regulation of sporulation
OPU65_RS17975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS17980	COG2162	N-hydroxyarylamine O-acetyltransferase activity
OPU65_RS17985	COG2732	(Barnase) inhibitor
OPU65_RS17990	COG4290	ribonuclease
OPU65_RS17995	COG0640	Transcriptional regulator
OPU65_RS18000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OPU65_RS18005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OPU65_RS18010	COG0288	reversible hydration of carbon dioxide
OPU65_RS18015	COG0659	secondary active sulfate transmembrane transporter activity
OPU65_RS18020	COG1078	dGTPase activity
OPU65_RS18025	COG1694	Mazg nucleotide pyrophosphohydrolase
OPU65_RS18030	COG1611	Belongs to the LOG family
OPU65_RS18035	COG0740	serine-type endopeptidase activity
OPU65_RS18050	COG4974	Belongs to the 'phage' integrase family
OPU65_RS18060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OPU65_RS18075	COG0457	Tetratricopeptide repeat
OPU65_RS18165	COG3617	BRO family, N-terminal domain
OPU65_RS18205	COG0582	viral genome integration into host DNA
OPU65_RS18310	COG1388	LysM domain
OPU65_RS18310	COG3409	Peptidoglycan-binding domain 1 protein
OPU65_RS18310	COG5632	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS18330	COG1621	beta-fructofuranosidase activity
OPU65_RS18335	COG1621	beta-fructofuranosidase activity
OPU65_RS18340	COG1902	pentaerythritol trinitrate reductase activity
OPU65_RS18345	COG1733	regulation of RNA biosynthetic process
OPU65_RS18350	COG2249	NAD(P)H dehydrogenase (quinone) activity
OPU65_RS18355	COG1396	sequence-specific DNA binding
OPU65_RS18360	COG3944	biosynthesis protein
OPU65_RS18365	COG0489	protein tyrosine kinase activity
OPU65_RS18370	COG1086	Polysaccharide biosynthesis protein
OPU65_RS18375	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS18380	COG1215	transferase activity, transferring glycosyl groups
OPU65_RS18385	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS18395	COG1216	Glycosyl transferase, family 2
OPU65_RS18400	COG5039	Polysaccharide pyruvyl transferase
OPU65_RS18405	COG1216	Glycosyl transferase, family 2
OPU65_RS18410	COG2244	polysaccharide biosynthetic process
OPU65_RS18415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OPU65_RS18420	COG0110	maltose O-acetyltransferase activity
OPU65_RS18425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OPU65_RS18430	COG5039	Polysaccharide pyruvyl transferase
OPU65_RS18440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OPU65_RS18445	COG1620	l-lactate permease
OPU65_RS18450	COG2186	Transcriptional regulator
OPU65_RS18455	COG0247	lactate metabolic process
OPU65_RS18460	COG1139	Iron-sulfur cluster binding protein
OPU65_RS18465	COG1556	Lactate utilization protein
OPU65_RS18475	COG1131	(ABC) transporter
OPU65_RS18485	COG1113	amino acid transport
OPU65_RS18490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OPU65_RS18495	COG2390	Transcriptional regulator
OPU65_RS18500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OPU65_RS18505	COG0126	phosphoglycerate kinase activity
OPU65_RS18510	COG0149	triose-phosphate isomerase activity
OPU65_RS18515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OPU65_RS18520	COG0148	phosphopyruvate hydratase activity
OPU65_RS18525	COG0693	protein deglycase activity
OPU65_RS18545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS18550	COG4640	response to antibiotic
OPU65_RS18560	COG3064	Membrane
OPU65_RS18570	COG1510	regulation of RNA biosynthetic process
OPU65_RS18575	COG0517	IMP dehydrogenase activity
OPU65_RS18575	COG1125	glycine betaine transport
OPU65_RS18580	COG1174	glycine betaine transport
OPU65_RS18585	COG1732	Glycine betaine
OPU65_RS18590	COG1174	glycine betaine transport
OPU65_RS18595	COG1396	sequence-specific DNA binding
OPU65_RS18600	COG1396	sequence-specific DNA binding
OPU65_RS18605	COG1476	TRANSCRIPTIONal
OPU65_RS18610	COG2002	toxin-antitoxin pair type II binding
OPU65_RS18615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OPU65_RS18620	COG1647	Serine aminopeptidase, S33
OPU65_RS18625	COG0557	exoribonuclease II activity
OPU65_RS18630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OPU65_RS18645	COG5444	nuclease activity
OPU65_RS18660	COG3507	Belongs to the glycosyl hydrolase 43 family
OPU65_RS18665	COG5520	Belongs to the glycosyl hydrolase 30 family
OPU65_RS18685	COG2140	Oxalate decarboxylase
OPU65_RS18695	COG1191	sigma factor activity
OPU65_RS18705	COG1054	Belongs to the UPF0176 family
OPU65_RS18720	COG1396	sequence-specific DNA binding
OPU65_RS18725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OPU65_RS18730	COG0673	inositol 2-dehydrogenase activity
OPU65_RS18740	COG1846	Transcriptional regulator
OPU65_RS18750	COG2124	cytochrome p450
OPU65_RS18760	COG2814	Major facilitator Superfamily
OPU65_RS18765	COG2814	Major facilitator Superfamily
OPU65_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS18770	COG3347	Dehydrogenase
OPU65_RS18780	COG4952	isomerase
OPU65_RS18785	COG1070	Carbohydrate kinase
OPU65_RS18790	COG1349	DNA-binding transcription factor activity
OPU65_RS18795	COG0693	protein deglycase activity
OPU65_RS18800	COG1937	Protein conserved in bacteria
OPU65_RS18805	COG2608	mercury ion transmembrane transporter activity
OPU65_RS18810	COG2217	Heavy metal translocating P-type atpase
OPU65_RS18830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS18830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OPU65_RS18830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS18835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OPU65_RS18835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OPU65_RS18850	COG0803	Belongs to the bacterial solute-binding protein 9 family
OPU65_RS18855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OPU65_RS18860	COG1121	(ABC) transporter
OPU65_RS18865	COG1472	Belongs to the glycosyl hydrolase 3 family
OPU65_RS18875	COG2217	Heavy metal translocating P-type atpase
OPU65_RS18880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OPU65_RS18885	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OPU65_RS18890	COG0456	acetyltransferase
OPU65_RS18895	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OPU65_RS18895	COG0456	acetyltransferase
OPU65_RS18900	COG2860	membrane
OPU65_RS18905	COG3973	AAA domain
OPU65_RS18910	COG0596	Alpha beta hydrolase
OPU65_RS18920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OPU65_RS18925	COG1940	carbohydrate kinase activity
OPU65_RS18930	COG0656	L-ascorbic acid biosynthetic process
OPU65_RS18935	COG2814	Major facilitator Superfamily
OPU65_RS18940	COG1368	sulfuric ester hydrolase activity
OPU65_RS18945	COG1988	membrane-bound metal-dependent
OPU65_RS18955	COG0531	amino acid
OPU65_RS18960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS18965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS18970	COG1120	ATPase activity
OPU65_RS18975	COG0745	RESPONSE REGULATOR receiver
OPU65_RS18980	COG2205	protein histidine kinase activity
OPU65_RS18985	COG1904	glucuronate isomerase
OPU65_RS18990	COG2211	Major facilitator Superfamily
OPU65_RS18995	COG1609	Transcriptional regulator
OPU65_RS19000	COG0246	Mannitol dehydrogenase
OPU65_RS19005	COG2721	sulfolactate sulfo-lyase activity
OPU65_RS19015	COG0583	DNA-binding transcription factor activity
OPU65_RS19020	COG2258	MOSC domain
OPU65_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS19030	COG1802	Transcriptional regulator
OPU65_RS19035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS19040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS19045	COG1120	ATPase activity
OPU65_RS19050	COG2096	Adenosyltransferase
OPU65_RS19055	COG4677	pectinesterase activity
OPU65_RS19060	COG4758	membrane
OPU65_RS19065	COG1842	Phage shock protein A
OPU65_RS19075	COG4758	membrane
OPU65_RS19080	COG4585	Histidine kinase
OPU65_RS19085	COG2197	response regulator
OPU65_RS19100	COG0814	amino acid
OPU65_RS19105	COG0697	spore germination
OPU65_RS19115	COG0114	fumarate hydratase activity
OPU65_RS19120	COG1309	transcriptional regulator
OPU65_RS19130	COG2770	Histidine kinase
OPU65_RS19130	COG2205	protein histidine kinase activity
OPU65_RS19135	COG0745	RESPONSE REGULATOR receiver
OPU65_RS19140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OPU65_RS19145	COG0783	Belongs to the Dps family
OPU65_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS19155	COG1686	Belongs to the peptidase S11 family
OPU65_RS19170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS19175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS19180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OPU65_RS19185	COG1120	ATPase activity
OPU65_RS19200	COG5577	PFAM Coat F domain
OPU65_RS19215	COG1024	Enoyl-CoA hydratase
OPU65_RS19215	COG1250	3-hydroxyacyl-CoA dehydrogenase
OPU65_RS19220	COG0183	Belongs to the thiolase family
OPU65_RS19225	COG1960	acyl-CoA dehydrogenase activity
OPU65_RS19230	COG1393	Belongs to the ArsC family
OPU65_RS19235	COG0509	glycine decarboxylation via glycine cleavage system
OPU65_RS19245	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
OPU65_RS19250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS19260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OPU65_RS19265	COG2011	ABC-type metal ion transport system permease component
OPU65_RS19270	COG1464	Belongs to the NlpA lipoprotein family
OPU65_RS19275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OPU65_RS19290	COG0396	ATPase activity
OPU65_RS19295	COG0719	Fe-S assembly protein
OPU65_RS19300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OPU65_RS19305	COG0822	iron-sulfur transferase activity
OPU65_RS19310	COG0719	Fe-S assembly protein
OPU65_RS19325	COG1396	sequence-specific DNA binding
OPU65_RS19410	COG0582	viral genome integration into host DNA
OPU65_RS19535	COG1705	Flagellar rod assembly protein muramidase FlgJ
OPU65_RS19540	COG5434	Belongs to the glycosyl hydrolase 28 family
OPU65_RS19585	COG5444	nuclease activity
OPU65_RS19610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OPU65_RS19620	COG0457	Tetratricopeptide repeat
OPU65_RS19635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OPU65_RS19645	COG2356	endonuclease I
OPU65_RS19650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OPU65_RS19655	COG1288	antiporter activity
OPU65_RS19660	COG2814	Major facilitator Superfamily
OPU65_RS19665	COG2508	Transcriptional regulator
OPU65_RS19670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OPU65_RS19675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OPU65_RS19680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OPU65_RS19690	COG3226	Transcriptional regulator
OPU65_RS19700	COG1801	Protein of unknown function DUF72
OPU65_RS19705	COG0730	response to heat
OPU65_RS19710	COG0737	Belongs to the 5'-nucleotidase family
OPU65_RS19715	COG3377	Domain of unknown function (DUF1805)
OPU65_RS19725	COG0733	neurotransmitter:sodium symporter activity
OPU65_RS19735	COG0739	heme binding
OPU65_RS19750	COG4470	Protein conserved in bacteria
OPU65_RS19755	COG2445	Protein of unknown function DUF86
OPU65_RS19760	COG0647	UMP catabolic process
OPU65_RS19765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OPU65_RS19770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OPU65_RS19780	COG0460	homoserine dehydrogenase
OPU65_RS19785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OPU65_RS19790	COG0083	homoserine kinase activity
OPU65_RS19795	COG0823	Involved in the tonB-independent uptake of proteins
OPU65_RS19795	COG1506	peptidase
OPU65_RS19795	COG4946	Tricorn protease homolog
OPU65_RS19805	COG4837	Protein of unknown function (DUF1462)
OPU65_RS19815	COG3479	Phenolic acid decarboxylase
OPU65_RS19820	COG0457	Tetratricopeptide repeat
OPU65_RS19835	COG5646	InterPro IPR014922
OPU65_RS19840	COG1252	NADH dehydrogenase
OPU65_RS19845	COG4844	belongs to the
OPU65_RS19850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OPU65_RS19855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OPU65_RS19860	COG0316	Belongs to the HesB IscA family
OPU65_RS19865	COG0456	acetyltransferase
OPU65_RS19880	COG0492	ferredoxin-NADP+ reductase activity
OPU65_RS19885	COG1252	NADH dehydrogenase
OPU65_RS19900	COG3584	3D domain protein
OPU65_RS19905	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
OPU65_RS19910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OPU65_RS19915	COG2056	Na+-H+ antiporter family
OPU65_RS19920	COG1268	BioY protein
OPU65_RS19925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OPU65_RS19935	COG0686	Belongs to the AlaDH PNT family
OPU65_RS19940	COG2508	Transcriptional regulator
OPU65_RS19940	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OPU65_RS19945	COG1115	amino acid carrier protein
OPU65_RS19950	COG4842	Belongs to the WXG100 family
OPU65_RS19955	COG5417	Belongs to the EsaB family
OPU65_RS19960	COG4499	WXG100 protein secretion system (Wss), protein YukC
OPU65_RS19965	COG0433	COG0433 Predicted ATPase
OPU65_RS19965	COG1674	ftsk spoiiie
OPU65_RS19970	COG1511	domain protein
OPU65_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS20000	COG0628	permease
OPU65_RS20015	COG5506	Protein of unknown function (DUF1694)
OPU65_RS20020	COG1335	isochorismatase
OPU65_RS20025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OPU65_RS20030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OPU65_RS20055	COG4585	Histidine kinase
OPU65_RS20060	COG2197	response regulator
OPU65_RS20065	COG2050	protein possibly involved in aromatic compounds catabolism
OPU65_RS20070	COG1320	monovalent cation:proton antiporter activity
OPU65_RS20075	COG2212	antiporter activity
OPU65_RS20080	COG1863	multisubunit Na H antiporter MnhE subunit
OPU65_RS20085	COG0651	ATP synthesis coupled electron transport
OPU65_RS20090	COG1006	Multisubunit Na H antiporter MnhC subunit
OPU65_RS20095	COG2111	Na H antiporter
OPU65_RS20100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OPU65_RS20100	COG2111	Na H antiporter
OPU65_RS20110	COG3493	citrate carrier protein
OPU65_RS20115	COG0688	phosphatidylethanolamine metabolic process
OPU65_RS20120	COG0586	Pfam SNARE associated Golgi protein
OPU65_RS20125	COG1183	phosphatidylcholine synthase activity
OPU65_RS20135	COG4565	transcriptional regulatory protein
OPU65_RS20140	COG3290	protein histidine kinase activity
OPU65_RS20150	COG3011	Protein conserved in bacteria
OPU65_RS20155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OPU65_RS20160	COG2814	Major facilitator Superfamily
OPU65_RS20165	COG5018	Exonuclease
OPU65_RS20180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OPU65_RS20195	COG2267	carboxylic ester hydrolase activity
OPU65_RS20200	COG1522	sequence-specific DNA binding
OPU65_RS20210	COG1098	S1 RNA binding domain
OPU65_RS20220	COG2155	Conserved Protein
OPU65_RS20225	COG1979	alcohol dehydrogenase
OPU65_RS20230	COG0166	Belongs to the GPI family
OPU65_RS20240	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
OPU65_RS20245	COG2323	membrane
OPU65_RS20255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OPU65_RS20270	COG2738	Putative neutral zinc metallopeptidase
OPU65_RS20275	COG1253	flavin adenine dinucleotide binding
OPU65_RS20280	COG5297	Belongs to the glycosyl hydrolase family 6
OPU65_RS20285	COG0366	Alpha amylase catalytic
OPU65_RS20290	COG0432	Pfam Uncharacterised protein family UPF0047
OPU65_RS20295	COG2070	2-Nitropropane dioxygenase
OPU65_RS20305	COG0840	transmembrane signaling receptor activity
OPU65_RS20310	COG0840	transmembrane signaling receptor activity
OPU65_RS20315	COG0840	transmembrane signaling receptor activity
OPU65_RS20320	COG0693	protein deglycase activity
OPU65_RS20325	COG0673	inositol 2-dehydrogenase activity
OPU65_RS20330	COG0628	permease
OPU65_RS20335	COG1968	undecaprenyl-diphosphatase activity
OPU65_RS20340	COG1408	metallophosphoesterase
OPU65_RS20345	COG0726	polysaccharide deacetylase
OPU65_RS20350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OPU65_RS20365	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
OPU65_RS20390	COG1397	ADP-ribosylglycohydrolase
OPU65_RS20420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OPU65_RS20425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OPU65_RS20430	COG1687	branched-chain amino acid
OPU65_RS20435	COG2140	Oxalate decarboxylase
OPU65_RS20440	COG2140	Oxalate decarboxylase
OPU65_RS20445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OPU65_RS20450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OPU65_RS20460	COG1510	regulation of RNA biosynthetic process
OPU65_RS20465	COG1012	belongs to the aldehyde dehydrogenase family
OPU65_RS20470	COG1454	alcohol dehydrogenase
OPU65_RS20480	COG2318	DinB family
OPU65_RS20490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OPU65_RS20495	COG0569	domain protein
OPU65_RS20500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OPU65_RS20510	COG0457	Tetratricopeptide repeat
OPU65_RS20525	COG3764	Sortase (surface protein transpeptidase)
OPU65_RS20530	COG3859	Proton-coupled thiamine transporter YuaJ
OPU65_RS20535	COG1609	Transcriptional regulator
OPU65_RS20655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OPU65_RS20660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OPU65_RS20665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OPU65_RS20670	COG0297	glycogen (starch) synthase activity
OPU65_RS20675	COG0058	SHG alpha-glucan phosphorylase activity
OPU65_RS20680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OPU65_RS20685	COG1575	Belongs to the MenA family. Type 1 subfamily
OPU65_RS20690	COG1169	isochorismate synthase
OPU65_RS20695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OPU65_RS20700	COG0596	Alpha beta hydrolase
OPU65_RS20705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OPU65_RS20710	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS20715	COG4948	Mandelate Racemase Muconate Lactonizing
OPU65_RS20730	COG1294	oxidase, subunit
OPU65_RS20735	COG1271	oxidase subunit
OPU65_RS20740	COG0254	rRNA binding
OPU65_RS20750	COG0803	Belongs to the bacterial solute-binding protein 9 family
OPU65_RS20755	COG0523	cobalamin synthesis protein
OPU65_RS20760	COG0288	reversible hydration of carbon dioxide
OPU65_RS20765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OPU65_RS20770	COG1854	S-ribosylhomocysteine lyase activity
OPU65_RS20785	COG0783	Belongs to the Dps family
OPU65_RS20790	COG4824	toxin secretion phage lysis holin
OPU65_RS20800	COG0494	nUDIX hydrolase
OPU65_RS20805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OPU65_RS20810	COG1116	anion transmembrane transporter activity
OPU65_RS20815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OPU65_RS20820	COG1506	peptidase
OPU65_RS20830	COG1301	dicarboxylic acid transport
OPU65_RS20835	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OPU65_RS20840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OPU65_RS20845	COG0367	asparagine synthase
OPU65_RS20850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OPU65_RS20850	COG0438	transferase activity, transferring glycosyl groups
OPU65_RS20855	COG0671	phosphoesterase, PA-phosphatase related
OPU65_RS20860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OPU65_RS20865	COG2267	carboxylic ester hydrolase activity
OPU65_RS20875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OPU65_RS20880	COG1242	4 iron, 4 sulfur cluster binding
OPU65_RS20895	COG1725	Transcriptional regulator
OPU65_RS20900	COG1131	(ABC) transporter
OPU65_RS20910	COG1136	(ABC) transporter
OPU65_RS20915	COG0577	efflux transmembrane transporter activity
OPU65_RS20920	COG2433	Pfam Transposase IS66
OPU65_RS20925	COG1464	Belongs to the NlpA lipoprotein family
OPU65_RS20930	COG2814	Major facilitator Superfamily
OPU65_RS20940	COG0495	leucyl-tRNA aminoacylation
OPU65_RS20945	COG0346	lactoylglutathione lyase activity
OPU65_RS20950	COG0583	DNA-binding transcription factor activity
OPU65_RS20960	COG1073	alpha beta
OPU65_RS20965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OPU65_RS20970	COG0395	ABC-type sugar transport system, permease component
OPU65_RS20975	COG1653	transport
OPU65_RS20980	COG2207	Transcriptional regulator
OPU65_RS20985	COG4209	transmembrane transport
OPU65_RS20990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OPU65_RS20995	COG1653	transport
OPU65_RS21000	COG0673	inositol 2-dehydrogenase activity
OPU65_RS21005	COG5578	integral membrane protein
OPU65_RS21015	COG0457	Tetratricopeptide repeat
OPU65_RS21025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OPU65_RS21035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OPU65_RS21045	COG2244	polysaccharide biosynthetic process
OPU65_RS21050	COG1187	pseudouridine synthase activity
OPU65_RS21055	COG1349	DNA-binding transcription factor activity
OPU65_RS21060	COG1131	(ABC) transporter
OPU65_RS21065	COG4473	ABC transporter
OPU65_RS21070	COG2252	PERMEase
OPU65_RS21075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OPU65_RS21090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OPU65_RS21095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OPU65_RS21105	COG1597	lipid kinase activity
OPU65_RS21110	COG1523	belongs to the glycosyl hydrolase 13 family
OPU65_RS21115	COG0510	thiamine kinase activity
OPU65_RS21125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OPU65_RS21130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OPU65_RS21135	COG0281	malic enzyme
OPU65_RS21140	COG5584	Small secreted protein
OPU65_RS21145	COG1363	Peptidase, m42
OPU65_RS21155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS21160	COG4848	Belongs to the UPF0354 family
OPU65_RS21165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OPU65_RS21170	COG1674	ftsk spoiiie
OPU65_RS21175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OPU65_RS21180	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
OPU65_RS21185	COG4980	gas vesicle protein
OPU65_RS21190	COG3118	belongs to the thioredoxin family
OPU65_RS21200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OPU65_RS21200	COG1605	Chorismate mutase
OPU65_RS21205	COG1609	Transcriptional regulator
OPU65_RS21210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OPU65_RS21215	COG1360	Flagellar Motor Protein
OPU65_RS21220	COG0123	including yeast histone deacetylase and acetoin utilization protein
OPU65_RS21225	COG0517	IMP dehydrogenase activity
OPU65_RS21230	COG0454	-acetyltransferase
OPU65_RS21235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OPU65_RS21240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OPU65_RS21260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OPU65_RS21265	COG2199	diguanylate cyclase activity
OPU65_RS21265	COG2203	Gaf domain
OPU65_RS21270	COG1956	GAF domain-containing protein
OPU65_RS21275	COG1309	transcriptional regulator
OPU65_RS21280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OPU65_RS21285	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
OPU65_RS21290	COG1114	Component of the transport system for branched-chain amino acids
OPU65_RS21295	COG1104	cysteine desulfurase activity
OPU65_RS21300	COG0301	tRNA thio-modification
OPU65_RS21310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OPU65_RS21315	COG1846	Transcriptional regulator
OPU65_RS21320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OPU65_RS21325	COG0616	signal peptide processing
OPU65_RS21330	COG1714	RDD family
OPU65_RS21340	COG3874	Sporulation protein YtfJ
OPU65_RS21345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OPU65_RS21350	COG0827	DNA restriction-modification system
OPU65_RS21355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OPU65_RS21360	COG0521	Mo-molybdopterin cofactor biosynthetic process
OPU65_RS21365	COG0137	argininosuccinate synthase activity
OPU65_RS21370	COG0165	Argininosuccinate lyase
OPU65_RS21380	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS21385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OPU65_RS21390	COG1695	Transcriptional regulator
OPU65_RS21395	COG4109	DRTGG domain
OPU65_RS21405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OPU65_RS21425	COG0587	DNA-directed DNA polymerase activity
OPU65_RS21430	COG0281	malic enzyme
OPU65_RS21440	COG0825	malonyl-CoA metabolic process
OPU65_RS21445	COG0205	6-phosphofructokinase activity
OPU65_RS21455	COG3030	protein affecting phage T7 exclusion by the F plasmid
OPU65_RS21460	COG0628	permease
OPU65_RS21465	COG2707	UPF0756 membrane protein
OPU65_RS21475	COG2273	Hydrolase Family 16
OPU65_RS21480	COG0372	Belongs to the citrate synthase family
OPU65_RS21485	COG0538	isocitrate dehydrogenase activity
OPU65_RS21490	COG0039	L-malate dehydrogenase activity
OPU65_RS21495	COG0745	RESPONSE REGULATOR receiver
OPU65_RS21500	COG5002	protein histidine kinase activity
OPU65_RS21505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OPU65_RS21505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OPU65_RS21510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OPU65_RS21515	COG1971	Probably functions as a manganese efflux pump
OPU65_RS21520	COG0237	dephospho-CoA kinase activity
OPU65_RS21530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OPU65_RS21535	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OPU65_RS21545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OPU65_RS21550	COG3611	Membrane attachment protein
OPU65_RS21555	COG1484	DNA-dependent DNA replication
OPU65_RS21560	COG0398	Pfam SNARE associated Golgi protein
OPU65_RS21570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OPU65_RS21575	COG1011	Hydrolase
OPU65_RS21585	COG3275	phosphorelay sensor kinase activity
OPU65_RS21590	COG3279	Response regulator of the LytR AlgR family
OPU65_RS21595	COG3540	Alkaline phosphatase
OPU65_RS21605	COG1346	cytolysis
OPU65_RS21610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OPU65_RS21615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OPU65_RS21620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OPU65_RS21625	COG3326	Membrane
OPU65_RS21635	COG1363	Peptidase, m42
OPU65_RS21640	COG3507	Belongs to the glycosyl hydrolase 43 family
OPU65_RS21645	COG2160	L-arabinose isomerase activity
OPU65_RS21650	COG1069	ribulokinase activity
OPU65_RS21655	COG0235	Class ii aldolase
OPU65_RS21660	COG0371	Dehydrogenase
OPU65_RS21665	COG1653	transport
OPU65_RS21670	COG1175	transmembrane transport
OPU65_RS21675	COG0395	ABC-type sugar transport system, permease component
OPU65_RS21690	COG1966	Carbon starvation protein
OPU65_RS21700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OPU65_RS21705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OPU65_RS21710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OPU65_RS21710	COG0072	phenylalanine-tRNA ligase activity
OPU65_RS21725	COG1137	ATPase activity
OPU65_RS21735	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OPU65_RS21740	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OPU65_RS21745	COG1286	toxin biosynthetic process
OPU65_RS21750	COG1796	DNA polymerase
OPU65_RS21750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OPU65_RS21755	COG1193	negative regulation of DNA recombination
OPU65_RS21760	COG3766	membrane
OPU65_RS21765	COG0318	PFAM AMP-dependent synthetase and ligase
OPU65_RS21770	COG1309	transcriptional regulator
OPU65_RS21775	COG1024	Enoyl-CoA hydratase
OPU65_RS21780	COG2086	electron transfer activity
OPU65_RS21785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OPU65_RS21790	COG3118	belongs to the thioredoxin family
OPU65_RS21795	COG0322	excinuclease ABC activity
OPU65_RS21800	COG0527	aspartate kinase activity
OPU65_RS21805	COG1719	4-vinyl reductase, 4VR
OPU65_RS21810	COG2009	succinate dehydrogenase
OPU65_RS21815	COG1053	succinate dehydrogenase
OPU65_RS21820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OPU65_RS21825	COG0824	Thioesterase
OPU65_RS21835	COG2197	response regulator
OPU65_RS21840	COG1846	Transcriptional regulator
OPU65_RS21845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OPU65_RS21850	COG5401	PFAM Sporulation and spore germination
OPU65_RS21855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OPU65_RS21860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OPU65_RS21865	COG0622	Phosphoesterase
OPU65_RS21890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OPU65_RS21900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OPU65_RS21905	COG0028	Belongs to the TPP enzyme family
OPU65_RS21910	COG0440	acetolactate synthase activity
OPU65_RS21915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OPU65_RS21920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OPU65_RS21925	COG0473	3-isopropylmalate dehydrogenase activity
OPU65_RS21930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OPU65_RS21935	COG0066	3-isopropylmalate dehydratase activity
OPU65_RS21940	COG0457	Tetratricopeptide repeat
OPU65_RS21940	COG1477	protein flavinylation
OPU65_RS21945	COG0544	peptidyl-prolyl cis-trans isomerase activity
OPU65_RS21950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OPU65_RS21955	COG1067	ATP-dependent peptidase activity
OPU65_RS21955	COG0470	DNA polymerase III
OPU65_RS21960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OPU65_RS21965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OPU65_RS21975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OPU65_RS21980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OPU65_RS21985	COG0181	hydroxymethylbilane synthase activity
OPU65_RS21990	COG1587	Uroporphyrinogen-III synthase
OPU65_RS21995	COG0113	porphobilinogen synthase activity
OPU65_RS22000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OPU65_RS22005	COG1388	LysM domain
OPU65_RS22010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OPU65_RS22020	COG0525	valine-tRNA ligase activity
OPU65_RS22025	COG0285	dihydrofolate synthase activity
OPU65_RS22030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OPU65_RS22040	COG2801	Transposase and inactivated derivatives
OPU65_RS22045	COG0424	maF-like protein
OPU65_RS22050	COG2003	Belongs to the UPF0758 family
OPU65_RS22055	COG1077	Cell shape determining protein MreB Mrl
OPU65_RS22065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OPU65_RS22070	COG0850	regulation of cytokinetic process
OPU65_RS22075	COG2894	cell division
OPU65_RS22080	COG0640	Transcriptional regulator
OPU65_RS22085	COG3832	glyoxalase III activity
OPU65_RS22090	COG0739	heme binding
OPU65_RS22095	COG1994	Peptidase M50
OPU65_RS22100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OPU65_RS22105	COG2868	ribosomal protein
OPU65_RS22110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OPU65_RS22115	COG3290	protein histidine kinase activity
OPU65_RS22120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OPU65_RS22125	COG4492	Belongs to the UPF0735 family
OPU65_RS22130	COG0077	Prephenate dehydratase
OPU65_RS22135	COG1827	regulation of RNA biosynthetic process
OPU65_RS22140	COG1104	cysteine desulfurase activity
OPU65_RS22145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OPU65_RS22150	COG0157	Belongs to the NadC ModD family
OPU65_RS22155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OPU65_RS22160	COG1388	LysM domain
OPU65_RS22170	COG0217	transcriptional regulatory protein
OPU65_RS22185	COG4195	phage-related replication protein
OPU65_RS22190	COG2318	DinB family
OPU65_RS22205	COG2112	serine threonine protein kinase
OPU65_RS22215	COG0632	four-way junction helicase activity
OPU65_RS22220	COG2255	four-way junction helicase activity
OPU65_RS22230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OPU65_RS22235	COG0343	queuine tRNA-ribosyltransferase activity
OPU65_RS22240	COG1862	Preprotein translocase
OPU65_RS22250	COG2323	membrane
OPU65_RS22255	COG2244	polysaccharide biosynthetic process
OPU65_RS22265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OPU65_RS22265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OPU65_RS22270	COG5416	Lipopolysaccharide assembly protein A domain
OPU65_RS22275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OPU65_RS22275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OPU65_RS22280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OPU65_RS22285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OPU65_RS22290	COG1490	D-aminoacyl-tRNA deacylase activity
OPU65_RS22295	COG4991	sh3 domain protein
OPU65_RS22295	COG0860	N-Acetylmuramoyl-L-alanine amidase
OPU65_RS22295	COG3103	Sh3 type 3 domain protein
OPU65_RS22305	COG0124	histidyl-tRNA synthetase
OPU65_RS22310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OPU65_RS22320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OPU65_RS22325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OPU65_RS22330	COG1959	2 iron, 2 sulfur cluster binding
OPU65_RS22335	COG1104	cysteine desulfurase activity
OPU65_RS22340	COG0482	sulfurtransferase activity
OPU65_RS22345	COG0457	Tetratricopeptide repeat
OPU65_RS22350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OPU65_RS22355	COG3881	PFAM PRC-barrel domain
OPU65_RS22370	COG0628	permease
OPU65_RS22375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OPU65_RS22380	COG4472	Bacterial protein of unknown function (DUF965)
OPU65_RS22385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OPU65_RS22390	COG3906	Belongs to the UPF0473 family
OPU65_RS22395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OPU65_RS22400	COG4122	O-methyltransferase activity
OPU65_RS22405	COG0826	peptidase U32
OPU65_RS22410	COG0826	peptidase U32
OPU65_RS22415	COG0572	uridine kinase
OPU65_RS22420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OPU65_RS22425	COG0768	penicillin binding
OPU65_RS22440	COG2226	methyltransferase
OPU65_RS22445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OPU65_RS22450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OPU65_RS22455	COG0626	cystathionine gamma-synthase activity
OPU65_RS22480	COG2226	methyltransferase
OPU65_RS22485	COG1404	Belongs to the peptidase S8 family
OPU65_RS22490	COG1309	transcriptional regulator
OPU65_RS22495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OPU65_RS22495	COG2124	cytochrome p450
OPU65_RS22505	COG2814	Major facilitator Superfamily
OPU65_RS22510	COG0583	DNA-binding transcription factor activity
OPU65_RS22515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OPU65_RS22530	COG1587	Uroporphyrinogen-III synthase
OPU65_RS22535	COG3340	Belongs to the peptidase S51 family
OPU65_RS22540	COG1733	regulation of RNA biosynthetic process
OPU65_RS22545	COG2814	Major facilitator Superfamily
OPU65_RS22550	COG0656	L-ascorbic acid biosynthetic process
OPU65_RS22555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OPU65_RS22560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OPU65_RS22570	COG2205	protein histidine kinase activity
OPU65_RS22575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OPU65_RS22580	COG2169	Transcriptional regulator
OPU65_RS22600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OPU65_RS22600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OPU65_RS22605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OPU65_RS22610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OPU65_RS22615	COG3715	PTS system
OPU65_RS22620	COG3716	PTS system mannose fructose sorbose family IID component
OPU65_RS22625	COG1621	beta-fructofuranosidase activity
OPU65_RS22630	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS22645	COG3507	Belongs to the glycosyl hydrolase 43 family
OPU65_RS22650	COG2124	cytochrome p450
OPU65_RS22665	COG1695	Transcriptional regulator
OPU65_RS22680	COG1028	Short-chain dehydrogenase reductase Sdr
OPU65_RS22700	COG4608	Belongs to the ABC transporter superfamily
OPU65_RS22705	COG0444	Belongs to the ABC transporter superfamily
OPU65_RS22710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OPU65_RS22715	COG0601	transmembrane transport
OPU65_RS22720	COG0747	negative chemotaxis
OPU65_RS22725	COG0492	ferredoxin-NADP+ reductase activity
OPU65_RS22730	COG2197	response regulator
OPU65_RS22735	COG4585	Histidine kinase
OPU65_RS22740	COG3239	Fatty acid desaturase
OPU65_RS22745	COG1733	regulation of RNA biosynthetic process
OPU65_RS22750	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OPU65_RS22755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OPU65_RS22760	COG1942	4-Oxalocrotonate Tautomerase
OPU65_RS22770	COG2226	methyltransferase
OPU65_RS22775	COG1937	Protein conserved in bacteria
OPU65_RS22780	COG2210	Belongs to the sulfur carrier protein TusA family
OPU65_RS22785	COG1054	Belongs to the UPF0176 family
OPU65_RS22790	COG0425	Belongs to the sulfur carrier protein TusA family
OPU65_RS22790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OPU65_RS22795	COG2210	Belongs to the sulfur carrier protein TusA family
OPU65_RS22805	COG0425	Belongs to the sulfur carrier protein TusA family
OPU65_RS22810	COG0730	response to heat
OPU65_RS22815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OPU65_RS22820	COG4585	Histidine kinase
OPU65_RS22845	COG0789	Transcriptional regulator
OPU65_RS22845	COG4978	Transcriptional regulator
OPU65_RS22860	COG1785	Belongs to the alkaline phosphatase family
OPU65_RS22870	COG2323	membrane
OPU65_RS22890	COG0640	Transcriptional regulator
OPU65_RS22895	COG0346	lactoylglutathione lyase activity
OPU65_RS22905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OPU65_RS22940	COG0454	-acetyltransferase
OPU65_RS22945	COG2311	Membrane
OPU65_RS22950	COG0745	RESPONSE REGULATOR receiver
OPU65_RS22955	COG0642	Histidine kinase
OPU65_RS22955	COG5002	protein histidine kinase activity
OPU65_RS22960	COG3223	Belongs to the PsiE family
OPU65_RS22990	COG1811	Na channel or pump
OPU65_RS22995	COG0789	Transcriptional regulator
OPU65_RS22995	COG4978	Transcriptional regulator
OPU65_RS23010	COG0659	secondary active sulfate transmembrane transporter activity
OPU65_RS23015	COG0589	response to stress
OPU65_RS23055	COG0640	Transcriptional regulator
OPU65_RS23060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OPU65_RS23095	COG0785	Cytochrome C biogenesis protein