locus-tag	class	description
D2B33_RS00010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D2B33_RS00015	COG0009	L-threonylcarbamoyladenylate synthase
D2B33_RS00020	COG1971	Probably functions as a manganese efflux pump
D2B33_RS00025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_RS00030	COG0698	ribose 5-phosphate isomerase
D2B33_RS00035	COG4475	Protein of unknown function (DUF436)
D2B33_RS00040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D2B33_RS00045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D2B33_RS00060	COG0356	it plays a direct role in the translocation of protons across the membrane
D2B33_RS00070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D2B33_RS00075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D2B33_RS00080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D2B33_RS00085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D2B33_RS00090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D2B33_RS00095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D2B33_RS00100	COG4836	Membrane
D2B33_RS00110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2B33_RS00115	COG2385	sporulation resulting in formation of a cellular spore
D2B33_RS00120	COG2304	oxidoreductase activity
D2B33_RS00125	COG2304	oxidoreductase activity
D2B33_RS00130	COG3383	formate dehydrogenase (NAD+) activity
D2B33_RS00135	COG2223	nitrite transmembrane transporter activity
D2B33_RS00140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D2B33_RS00145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D2B33_RS00150	COG1994	Peptidase M50
D2B33_RS00160	COG1959	2 iron, 2 sulfur cluster binding
D2B33_RS00170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_RS00185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS00185	COG2207	Transcriptional regulator
D2B33_RS00190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS00195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS00200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS00205	COG2819	hydrolase of the alpha beta superfamily
D2B33_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS00215	COG1169	isochorismate synthase
D2B33_RS00220	COG1021	2,3-dihydroxybenzoate-AMP ligase
D2B33_RS00225	COG1535	isochorismatase
D2B33_RS00225	COG3433	isochorismatase activity
D2B33_RS00230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS00235	COG3251	PFAM MbtH domain protein
D2B33_RS00240	COG0477	Major facilitator Superfamily
D2B33_RS00245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_RS00255	COG1247	-acetyltransferase
D2B33_RS00260	COG0739	heme binding
D2B33_RS00270	COG0740	serine-type endopeptidase activity
D2B33_RS00280	COG0347	Belongs to the P(II) protein family
D2B33_RS00290	COG1253	flavin adenine dinucleotide binding
D2B33_RS00295	COG0598	Magnesium transport protein CorA
D2B33_RS00300	COG0517	IMP dehydrogenase activity
D2B33_RS00315	COG3361	conserved protein (COG2071)
D2B33_RS00320	COG3546	catalase activity
D2B33_RS00325	COG1227	inorganic diphosphatase activity
D2B33_RS00330	COG0671	phosphoesterase, PA-phosphatase related
D2B33_RS00335	COG2814	Major facilitator Superfamily
D2B33_RS00340	COG1846	Transcriptional regulator
D2B33_RS00350	COG1609	Transcriptional regulator
D2B33_RS00355	COG1077	Cell shape determining protein MreB Mrl
D2B33_RS00360	COG4786	Flagellar basal body rod
D2B33_RS00365	COG4786	Flagellar basal body rod
D2B33_RS00370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D2B33_RS00375	COG1970	mechanosensitive ion channel activity
D2B33_RS00390	COG0629	single-stranded DNA binding
D2B33_RS00410	COG3732	PTS system glucitol sorbitol-specific
D2B33_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS00430	COG1349	DNA-binding transcription factor activity
D2B33_RS00435	COG0561	phosphatase activity
D2B33_RS00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D2B33_RS00455	COG3878	Protein conserved in bacteria
D2B33_RS00465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2B33_RS00470	COG4715	Zinc finger, swim domain protein
D2B33_RS00480	COG3944	biosynthesis protein
D2B33_RS00485	COG4464	protein tyrosine phosphatase activity
D2B33_RS00490	COG2059	Chromate
D2B33_RS00495	COG2059	Chromate
D2B33_RS00500	COG1522	sequence-specific DNA binding
D2B33_RS00505	COG0405	Gamma-glutamyltransferase
D2B33_RS00510	COG0583	DNA-binding transcription factor activity
D2B33_RS00515	COG0028	Belongs to the TPP enzyme family
D2B33_RS00520	COG3527	Alpha-acetolactate decarboxylase
D2B33_RS00525	COG2226	methyltransferase
D2B33_RS00530	COG0583	DNA-binding transcription factor activity
D2B33_RS00535	COG1879	ABC-type sugar transport system periplasmic component
D2B33_RS00540	COG1172	Belongs to the binding-protein-dependent transport system permease family
D2B33_RS00550	COG1869	D-ribose catabolic process
D2B33_RS00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_RS00560	COG1609	Transcriptional regulator
D2B33_RS00565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D2B33_RS00575	COG2843	Capsule synthesis protein
D2B33_RS00580	COG0791	NLP P60 protein
D2B33_RS00585	COG0561	phosphatase activity
D2B33_RS00590	COG1316	TRANSCRIPTIONal
D2B33_RS00595	COG2814	Major facilitator Superfamily
D2B33_RS00600	COG1063	alcohol dehydrogenase
D2B33_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS00610	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D2B33_RS00615	COG1609	Transcriptional regulator
D2B33_RS00620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_RS00625	COG0800	Aldolase
D2B33_RS00645	COG1482	cell wall glycoprotein biosynthetic process
D2B33_RS00650	COG4193	domain, Protein
D2B33_RS00655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_RS00660	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D2B33_RS00665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D2B33_RS00670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_RS00675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_RS00675	COG0463	Glycosyl transferase, family 2
D2B33_RS00680	COG1682	transport, permease protein
D2B33_RS00685	COG1134	teichoic acid transport
D2B33_RS00705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_RS00725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2B33_RS00730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D2B33_RS00740	COG1316	TRANSCRIPTIONal
D2B33_RS00750	COG2247	cell wall binding repeat
D2B33_RS00750	COG2385	sporulation resulting in formation of a cellular spore
D2B33_RS00755	COG2247	cell wall binding repeat
D2B33_RS00755	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS00765	COG2244	polysaccharide biosynthetic process
D2B33_RS00770	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS00770	COG0297	glycogen (starch) synthase activity
D2B33_RS00775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D2B33_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_RS00785	COG3307	-O-antigen
D2B33_RS00790	COG3206	protein involved in exopolysaccharide biosynthesis
D2B33_RS00795	COG1215	transferase activity, transferring glycosyl groups
D2B33_RS00800	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS00805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2B33_RS00815	COG1316	TRANSCRIPTIONal
D2B33_RS00820	COG1739	Uncharacterized protein family UPF0029
D2B33_RS00825	COG4585	Histidine kinase
D2B33_RS00830	COG2197	response regulator
D2B33_RS00835	COG1307	EDD domain protein, DegV family
D2B33_RS00840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D2B33_RS00850	COG1040	competence protein
D2B33_RS00860	COG2747	anti-sigma28 factor FlgM
D2B33_RS00865	COG3418	PFAM FlgN family protein
D2B33_RS00870	COG1256	bacterial-type flagellum assembly
D2B33_RS00870	COG4786	Flagellar basal body rod
D2B33_RS00875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2B33_RS00885	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D2B33_RS00890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D2B33_RS00895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2B33_RS00905	COG1334	flagellar protein FlaG
D2B33_RS00910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D2B33_RS00915	COG1516	flagellar protein fliS
D2B33_RS00930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D2B33_RS00935	COG0653	protein targeting
D2B33_RS00945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS00950	COG2010	Cytochrome c
D2B33_RS00955	COG2884	Cell division ATP-binding protein ftsE
D2B33_RS00960	COG2177	Part of the ABC transporter FtsEX involved in
D2B33_RS00965	COG0791	NLP P60 protein
D2B33_RS00965	COG3883	PFAM NLP P60 protein
D2B33_RS00970	COG0473	3-isopropylmalate dehydrogenase activity
D2B33_RS00975	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_RS00975	COG0793	Belongs to the peptidase S41A family
D2B33_RS00985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_RS00995	COG4897	Protein conserved in bacteria
D2B33_RS01000	COG0556	nucleotide-excision repair
D2B33_RS01005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D2B33_RS01025	COG3595	metallopeptidase activity
D2B33_RS01030	COG1983	PspC domain protein
D2B33_RS01035	COG1950	PFAM Membrane protein of
D2B33_RS01040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D2B33_RS01045	COG2814	Major facilitator Superfamily
D2B33_RS01050	COG1846	Transcriptional regulator
D2B33_RS01055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D2B33_RS01060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D2B33_RS01065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D2B33_RS01070	COG0546	phosphoglycolate phosphatase activity
D2B33_RS01075	COG0110	maltose O-acetyltransferase activity
D2B33_RS01080	COG5297	Belongs to the glycosyl hydrolase family 6
D2B33_RS01085	COG4990	cell redox homeostasis
D2B33_RS01090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D2B33_RS01095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D2B33_RS01100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D2B33_RS01105	COG0131	Imidazoleglycerol-phosphate dehydratase
D2B33_RS01110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D2B33_RS01115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D2B33_RS01120	COG0107	imidazoleglycerol-phosphate synthase activity
D2B33_RS01125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D2B33_RS01125	COG0140	phosphoribosyl-ATP diphosphatase activity
D2B33_RS01130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_RS01135	COG0457	Tetratricopeptide repeat
D2B33_RS01140	COG0492	ferredoxin-NADP+ reductase activity
D2B33_RS01150	COG1051	belongs to the nudix hydrolase family
D2B33_RS01155	COG1660	Displays ATPase and GTPase activities
D2B33_RS01160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D2B33_RS01165	COG1481	regulation of sporulation
D2B33_RS01170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS01175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D2B33_RS01180	COG2732	(Barnase) inhibitor
D2B33_RS01190	COG0640	Transcriptional regulator
D2B33_RS01195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D2B33_RS01200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_RS01205	COG0288	reversible hydration of carbon dioxide
D2B33_RS01210	COG0659	secondary active sulfate transmembrane transporter activity
D2B33_RS01215	COG1078	dGTPase activity
D2B33_RS01220	COG1694	Mazg nucleotide pyrophosphohydrolase
D2B33_RS01225	COG1611	Belongs to the LOG family
D2B33_RS01230	COG0740	serine-type endopeptidase activity
D2B33_RS01245	COG1621	beta-fructofuranosidase activity
D2B33_RS01250	COG1621	beta-fructofuranosidase activity
D2B33_RS01255	COG1902	pentaerythritol trinitrate reductase activity
D2B33_RS01260	COG1733	regulation of RNA biosynthetic process
D2B33_RS01270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_RS01275	COG1454	alcohol dehydrogenase
D2B33_RS01285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D2B33_RS01295	COG2271	Major facilitator Superfamily
D2B33_RS01300	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS01310	COG1396	sequence-specific DNA binding
D2B33_RS01315	COG3944	biosynthesis protein
D2B33_RS01320	COG0489	protein tyrosine kinase activity
D2B33_RS01325	COG1086	Polysaccharide biosynthesis protein
D2B33_RS01330	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS01335	COG1215	transferase activity, transferring glycosyl groups
D2B33_RS01340	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS01350	COG1216	Glycosyl transferase, family 2
D2B33_RS01355	COG5039	Polysaccharide pyruvyl transferase
D2B33_RS01360	COG1216	Glycosyl transferase, family 2
D2B33_RS01380	COG0110	maltose O-acetyltransferase activity
D2B33_RS01385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_RS01390	COG5039	Polysaccharide pyruvyl transferase
D2B33_RS01400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D2B33_RS01405	COG1620	l-lactate permease
D2B33_RS01410	COG2186	Transcriptional regulator
D2B33_RS01415	COG0247	lactate metabolic process
D2B33_RS01420	COG1139	Iron-sulfur cluster binding protein
D2B33_RS01425	COG1556	Lactate utilization protein
D2B33_RS01445	COG1113	amino acid transport
D2B33_RS01450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_RS01455	COG2390	Transcriptional regulator
D2B33_RS01460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2B33_RS01465	COG0126	phosphoglycerate kinase activity
D2B33_RS01470	COG0149	triose-phosphate isomerase activity
D2B33_RS01475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D2B33_RS01480	COG0148	phosphopyruvate hydratase activity
D2B33_RS01485	COG0693	protein deglycase activity
D2B33_RS01500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS01505	COG4640	response to antibiotic
D2B33_RS01510	COG3064	Membrane
D2B33_RS01515	COG2095	MarC family integral membrane protein
D2B33_RS01520	COG1510	regulation of RNA biosynthetic process
D2B33_RS01525	COG0517	IMP dehydrogenase activity
D2B33_RS01525	COG1125	glycine betaine transport
D2B33_RS01530	COG1174	glycine betaine transport
D2B33_RS01535	COG1732	Glycine betaine
D2B33_RS01540	COG1174	glycine betaine transport
D2B33_RS01545	COG1396	sequence-specific DNA binding
D2B33_RS01550	COG1396	sequence-specific DNA binding
D2B33_RS01555	COG1476	TRANSCRIPTIONal
D2B33_RS01560	COG2002	toxin-antitoxin pair type II binding
D2B33_RS01565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D2B33_RS01570	COG1647	Serine aminopeptidase, S33
D2B33_RS01575	COG0557	exoribonuclease II activity
D2B33_RS01580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D2B33_RS01600	COG5444	nuclease activity
D2B33_RS01620	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS01625	COG5520	Belongs to the glycosyl hydrolase 30 family
D2B33_RS01645	COG2140	Oxalate decarboxylase
D2B33_RS01655	COG1191	sigma factor activity
D2B33_RS01665	COG1054	Belongs to the UPF0176 family
D2B33_RS01670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2B33_RS01675	COG0673	inositol 2-dehydrogenase activity
D2B33_RS01685	COG1846	Transcriptional regulator
D2B33_RS01695	COG2124	cytochrome p450
D2B33_RS01705	COG2814	Major facilitator Superfamily
D2B33_RS01710	COG2814	Major facilitator Superfamily
D2B33_RS01715	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS01715	COG3347	Dehydrogenase
D2B33_RS01725	COG4952	isomerase
D2B33_RS01730	COG1070	Carbohydrate kinase
D2B33_RS01735	COG1349	DNA-binding transcription factor activity
D2B33_RS01740	COG0693	protein deglycase activity
D2B33_RS01745	COG1937	Protein conserved in bacteria
D2B33_RS01750	COG2608	mercury ion transmembrane transporter activity
D2B33_RS01755	COG2217	Heavy metal translocating P-type atpase
D2B33_RS01770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS01770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS01790	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2B33_RS01795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2B33_RS01800	COG1121	(ABC) transporter
D2B33_RS01805	COG1472	Belongs to the glycosyl hydrolase 3 family
D2B33_RS01810	COG1501	Belongs to the glycosyl hydrolase 31 family
D2B33_RS01815	COG0395	ABC-type sugar transport system, permease component
D2B33_RS01820	COG1175	transmembrane transport
D2B33_RS01825	COG1653	transport
D2B33_RS01830	COG2217	Heavy metal translocating P-type atpase
D2B33_RS01835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D2B33_RS01840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D2B33_RS01845	COG0456	acetyltransferase
D2B33_RS01850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D2B33_RS01850	COG0456	acetyltransferase
D2B33_RS01855	COG2860	membrane
D2B33_RS01860	COG3973	AAA domain
D2B33_RS01865	COG0596	Alpha beta hydrolase
D2B33_RS01875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2B33_RS01880	COG1940	carbohydrate kinase activity
D2B33_RS01885	COG0656	L-ascorbic acid biosynthetic process
D2B33_RS01890	COG2814	Major facilitator Superfamily
D2B33_RS01895	COG1368	sulfuric ester hydrolase activity
D2B33_RS01900	COG1988	membrane-bound metal-dependent
D2B33_RS01910	COG0531	amino acid
D2B33_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS01925	COG1120	ATPase activity
D2B33_RS01930	COG0745	RESPONSE REGULATOR receiver
D2B33_RS01935	COG2205	protein histidine kinase activity
D2B33_RS01940	COG1904	glucuronate isomerase
D2B33_RS01945	COG2211	Major facilitator Superfamily
D2B33_RS01950	COG1609	Transcriptional regulator
D2B33_RS01955	COG0246	Mannitol dehydrogenase
D2B33_RS01960	COG2721	sulfolactate sulfo-lyase activity
D2B33_RS01970	COG0583	DNA-binding transcription factor activity
D2B33_RS01975	COG2258	MOSC domain
D2B33_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS01985	COG1802	Transcriptional regulator
D2B33_RS01990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS02000	COG1120	ATPase activity
D2B33_RS02005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_RS02010	COG1454	alcohol dehydrogenase
D2B33_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS02035	COG2096	Adenosyltransferase
D2B33_RS02040	COG4677	pectinesterase activity
D2B33_RS02045	COG4758	membrane
D2B33_RS02050	COG1842	Phage shock protein A
D2B33_RS02060	COG4758	membrane
D2B33_RS02065	COG4585	Histidine kinase
D2B33_RS02070	COG2197	response regulator
D2B33_RS02085	COG0814	amino acid
D2B33_RS02090	COG0697	spore germination
D2B33_RS02100	COG0114	fumarate hydratase activity
D2B33_RS02105	COG1309	transcriptional regulator
D2B33_RS02110	COG2205	protein histidine kinase activity
D2B33_RS02110	COG2770	Histidine kinase
D2B33_RS02115	COG0745	RESPONSE REGULATOR receiver
D2B33_RS02120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_RS02125	COG0783	Belongs to the Dps family
D2B33_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS02135	COG1686	Belongs to the peptidase S11 family
D2B33_RS02150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS02155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS02160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS02165	COG1120	ATPase activity
D2B33_RS02180	COG5577	PFAM Coat F domain
D2B33_RS02195	COG1024	Enoyl-CoA hydratase
D2B33_RS02195	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2B33_RS02200	COG0183	Belongs to the thiolase family
D2B33_RS02205	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS02210	COG1393	Belongs to the ArsC family
D2B33_RS02215	COG0509	glycine decarboxylation via glycine cleavage system
D2B33_RS02225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2B33_RS02230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS02240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2B33_RS02245	COG2011	ABC-type metal ion transport system permease component
D2B33_RS02250	COG1464	Belongs to the NlpA lipoprotein family
D2B33_RS02255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D2B33_RS02265	COG0396	ATPase activity
D2B33_RS02270	COG0719	Fe-S assembly protein
D2B33_RS02275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2B33_RS02280	COG0822	iron-sulfur transferase activity
D2B33_RS02285	COG0719	Fe-S assembly protein
D2B33_RS02295	COG0457	Tetratricopeptide repeat
D2B33_RS02310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2B33_RS02320	COG2356	endonuclease I
D2B33_RS02335	COG1288	antiporter activity
D2B33_RS02340	COG2814	Major facilitator Superfamily
D2B33_RS02345	COG2508	Transcriptional regulator
D2B33_RS02350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D2B33_RS02355	COG3226	Transcriptional regulator
D2B33_RS02365	COG1801	Protein of unknown function DUF72
D2B33_RS02370	COG0730	response to heat
D2B33_RS02375	COG0737	Belongs to the 5'-nucleotidase family
D2B33_RS02380	COG3377	Domain of unknown function (DUF1805)
D2B33_RS02390	COG0733	neurotransmitter:sodium symporter activity
D2B33_RS02400	COG0739	heme binding
D2B33_RS02415	COG4470	Protein conserved in bacteria
D2B33_RS02420	COG2445	Protein of unknown function DUF86
D2B33_RS02425	COG0647	UMP catabolic process
D2B33_RS02430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D2B33_RS02435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2B33_RS02440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_RS02445	COG0460	homoserine dehydrogenase
D2B33_RS02450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D2B33_RS02455	COG0083	homoserine kinase activity
D2B33_RS02460	COG0823	Involved in the tonB-independent uptake of proteins
D2B33_RS02460	COG4946	Tricorn protease homolog
D2B33_RS02460	COG1506	peptidase
D2B33_RS02465	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D2B33_RS02470	COG4837	Protein of unknown function (DUF1462)
D2B33_RS02480	COG3479	Phenolic acid decarboxylase
D2B33_RS02485	COG0457	Tetratricopeptide repeat
D2B33_RS02500	COG5646	InterPro IPR014922
D2B33_RS02505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D2B33_RS02510	COG2323	membrane
D2B33_RS02515	COG1252	NADH dehydrogenase
D2B33_RS02520	COG4844	belongs to the
D2B33_RS02525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2B33_RS02530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D2B33_RS02535	COG0316	Belongs to the HesB IscA family
D2B33_RS02540	COG0454	-acetyltransferase
D2B33_RS02555	COG0492	ferredoxin-NADP+ reductase activity
D2B33_RS02560	COG1252	NADH dehydrogenase
D2B33_RS02570	COG3584	3D domain protein
D2B33_RS02575	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D2B33_RS02580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D2B33_RS02585	COG2056	Na+-H+ antiporter family
D2B33_RS02590	COG1268	BioY protein
D2B33_RS02595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2B33_RS02605	COG0686	Belongs to the AlaDH PNT family
D2B33_RS02610	COG2508	Transcriptional regulator
D2B33_RS02610	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2B33_RS02615	COG1115	amino acid carrier protein
D2B33_RS02620	COG4842	Belongs to the WXG100 family
D2B33_RS02625	COG5417	Belongs to the EsaB family
D2B33_RS02630	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2B33_RS02635	COG0433	COG0433 Predicted ATPase
D2B33_RS02635	COG1674	ftsk spoiiie
D2B33_RS02640	COG1511	domain protein
D2B33_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS02660	COG1418	mRNA catabolic process
D2B33_RS02670	COG0657	acetylesterase activity
D2B33_RS02675	COG1959	2 iron, 2 sulfur cluster binding
D2B33_RS02680	COG0628	permease
D2B33_RS02695	COG5506	Protein of unknown function (DUF1694)
D2B33_RS02700	COG1335	isochorismatase
D2B33_RS02705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D2B33_RS02710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D2B33_RS02740	COG3226	Transcriptional regulator
D2B33_RS02760	COG4585	Histidine kinase
D2B33_RS02765	COG2197	response regulator
D2B33_RS02770	COG2050	protein possibly involved in aromatic compounds catabolism
D2B33_RS02775	COG1320	monovalent cation:proton antiporter activity
D2B33_RS02780	COG2212	antiporter activity
D2B33_RS02785	COG1863	multisubunit Na H antiporter MnhE subunit
D2B33_RS02790	COG0651	ATP synthesis coupled electron transport
D2B33_RS02795	COG1006	Multisubunit Na H antiporter MnhC subunit
D2B33_RS02800	COG2111	Na H antiporter
D2B33_RS02805	COG2111	Na H antiporter
D2B33_RS02805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D2B33_RS02815	COG3493	citrate carrier protein
D2B33_RS02820	COG0688	phosphatidylethanolamine metabolic process
D2B33_RS02825	COG0586	Pfam SNARE associated Golgi protein
D2B33_RS02830	COG1183	phosphatidylcholine synthase activity
D2B33_RS02840	COG4565	transcriptional regulatory protein
D2B33_RS02845	COG3290	protein histidine kinase activity
D2B33_RS02855	COG3011	Protein conserved in bacteria
D2B33_RS02860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_RS02865	COG2814	Major facilitator Superfamily
D2B33_RS02870	COG5018	Exonuclease
D2B33_RS02885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D2B33_RS02900	COG2267	carboxylic ester hydrolase activity
D2B33_RS02905	COG1522	sequence-specific DNA binding
D2B33_RS02910	COG0436	Aminotransferase
D2B33_RS02915	COG1098	S1 RNA binding domain
D2B33_RS02920	COG2155	Conserved Protein
D2B33_RS02925	COG1979	alcohol dehydrogenase
D2B33_RS02930	COG0166	Belongs to the GPI family
D2B33_RS02940	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D2B33_RS02945	COG2323	membrane
D2B33_RS02955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D2B33_RS02970	COG2738	Putative neutral zinc metallopeptidase
D2B33_RS02975	COG1253	flavin adenine dinucleotide binding
D2B33_RS02980	COG5297	Belongs to the glycosyl hydrolase family 6
D2B33_RS02995	COG0366	Alpha amylase catalytic
D2B33_RS03000	COG0432	Pfam Uncharacterised protein family UPF0047
D2B33_RS03005	COG2070	2-Nitropropane dioxygenase
D2B33_RS03015	COG0840	transmembrane signaling receptor activity
D2B33_RS03020	COG0840	transmembrane signaling receptor activity
D2B33_RS03025	COG0840	transmembrane signaling receptor activity
D2B33_RS03030	COG0693	protein deglycase activity
D2B33_RS03035	COG0673	inositol 2-dehydrogenase activity
D2B33_RS03040	COG0628	permease
D2B33_RS03045	COG1968	undecaprenyl-diphosphatase activity
D2B33_RS03050	COG1408	metallophosphoesterase
D2B33_RS03055	COG0726	polysaccharide deacetylase
D2B33_RS03060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_RS03070	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D2B33_RS03160	COG1397	ADP-ribosylglycohydrolase
D2B33_RS03170	COG4974	Belongs to the 'phage' integrase family
D2B33_RS03305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_RS03305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_RS03345	COG1780	Probably involved in ribonucleotide reductase function
D2B33_RS03350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_RS03385	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D2B33_RS03390	COG3584	3D domain protein
D2B33_RS03445	COG1793	dna ligase
D2B33_RS03595	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_RS03595	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS03595	COG1388	LysM domain
D2B33_RS03630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2B33_RS03635	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D2B33_RS03645	COG1510	regulation of RNA biosynthetic process
D2B33_RS03650	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS03655	COG1454	alcohol dehydrogenase
D2B33_RS03665	COG2318	DinB family
D2B33_RS03680	COG0569	domain protein
D2B33_RS03685	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D2B33_RS03690	COG0457	Tetratricopeptide repeat
D2B33_RS03705	COG3764	Sortase (surface protein transpeptidase)
D2B33_RS03710	COG3859	Proton-coupled thiamine transporter YuaJ
D2B33_RS03715	COG1609	Transcriptional regulator
D2B33_RS03835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D2B33_RS03840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D2B33_RS03845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D2B33_RS03850	COG0297	glycogen (starch) synthase activity
D2B33_RS03855	COG0058	SHG alpha-glucan phosphorylase activity
D2B33_RS03860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_RS03865	COG1575	Belongs to the MenA family. Type 1 subfamily
D2B33_RS03870	COG1169	isochorismate synthase
D2B33_RS03875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D2B33_RS03880	COG0596	Alpha beta hydrolase
D2B33_RS03885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D2B33_RS03890	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS03895	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_RS03910	COG1294	oxidase, subunit
D2B33_RS03915	COG1271	oxidase subunit
D2B33_RS03920	COG0254	rRNA binding
D2B33_RS03925	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2B33_RS03930	COG0523	cobalamin synthesis protein
D2B33_RS03935	COG0288	reversible hydration of carbon dioxide
D2B33_RS03940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D2B33_RS03945	COG1854	S-ribosylhomocysteine lyase activity
D2B33_RS03960	COG0783	Belongs to the Dps family
D2B33_RS03965	COG4824	toxin secretion phage lysis holin
D2B33_RS03975	COG0494	nUDIX hydrolase
D2B33_RS03980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2B33_RS03985	COG1116	anion transmembrane transporter activity
D2B33_RS03990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2B33_RS03995	COG1506	peptidase
D2B33_RS04010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D2B33_RS04015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D2B33_RS04020	COG0367	asparagine synthase
D2B33_RS04025	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS04025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_RS04030	COG0671	phosphoesterase, PA-phosphatase related
D2B33_RS04035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D2B33_RS04040	COG2267	carboxylic ester hydrolase activity
D2B33_RS04050	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D2B33_RS04055	COG1242	4 iron, 4 sulfur cluster binding
D2B33_RS04065	COG1725	Transcriptional regulator
D2B33_RS04070	COG1131	(ABC) transporter
D2B33_RS04080	COG1136	(ABC) transporter
D2B33_RS04085	COG0577	efflux transmembrane transporter activity
D2B33_RS04095	COG1464	Belongs to the NlpA lipoprotein family
D2B33_RS04100	COG2814	Major facilitator Superfamily
D2B33_RS04110	COG0495	leucyl-tRNA aminoacylation
D2B33_RS04115	COG0346	lactoylglutathione lyase activity
D2B33_RS04120	COG0583	DNA-binding transcription factor activity
D2B33_RS04130	COG1073	alpha beta
D2B33_RS04135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_RS04140	COG0395	ABC-type sugar transport system, permease component
D2B33_RS04145	COG1653	transport
D2B33_RS04150	COG2207	Transcriptional regulator
D2B33_RS04155	COG4209	transmembrane transport
D2B33_RS04160	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D2B33_RS04165	COG1653	transport
D2B33_RS04170	COG0673	inositol 2-dehydrogenase activity
D2B33_RS04175	COG5578	integral membrane protein
D2B33_RS04190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_RS04200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D2B33_RS04205	COG2081	HI0933 family
D2B33_RS04210	COG2244	polysaccharide biosynthetic process
D2B33_RS04215	COG1187	pseudouridine synthase activity
D2B33_RS04220	COG1349	DNA-binding transcription factor activity
D2B33_RS04225	COG1131	(ABC) transporter
D2B33_RS04230	COG4473	ABC transporter
D2B33_RS04235	COG2252	PERMEase
D2B33_RS04240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_RS04255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_RS04260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D2B33_RS04270	COG1597	lipid kinase activity
D2B33_RS04275	COG1523	belongs to the glycosyl hydrolase 13 family
D2B33_RS04280	COG0510	thiamine kinase activity
D2B33_RS04290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D2B33_RS04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS04300	COG0281	malic enzyme
D2B33_RS04305	COG5584	Small secreted protein
D2B33_RS04310	COG1363	Peptidase, m42
D2B33_RS04320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS04325	COG4848	Belongs to the UPF0354 family
D2B33_RS04330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_RS04335	COG1674	ftsk spoiiie
D2B33_RS04340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D2B33_RS04345	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D2B33_RS04350	COG4980	gas vesicle protein
D2B33_RS04355	COG3118	belongs to the thioredoxin family
D2B33_RS04365	COG1605	Chorismate mutase
D2B33_RS04365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D2B33_RS04370	COG1609	Transcriptional regulator
D2B33_RS04375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2B33_RS04380	COG1360	Flagellar Motor Protein
D2B33_RS04385	COG0123	including yeast histone deacetylase and acetoin utilization protein
D2B33_RS04390	COG0517	IMP dehydrogenase activity
D2B33_RS04395	COG0454	-acetyltransferase
D2B33_RS04400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_RS04405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D2B33_RS04420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D2B33_RS04425	COG2203	Gaf domain
D2B33_RS04425	COG2199	diguanylate cyclase activity
D2B33_RS04430	COG1956	GAF domain-containing protein
D2B33_RS04435	COG1309	transcriptional regulator
D2B33_RS04440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2B33_RS04445	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D2B33_RS04450	COG1114	Component of the transport system for branched-chain amino acids
D2B33_RS04455	COG1104	cysteine desulfurase activity
D2B33_RS04460	COG0301	tRNA thio-modification
D2B33_RS04470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_RS04475	COG1846	Transcriptional regulator
D2B33_RS04480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2B33_RS04485	COG0616	signal peptide processing
D2B33_RS04490	COG1714	RDD family
D2B33_RS04500	COG3874	Sporulation protein YtfJ
D2B33_RS04505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D2B33_RS04510	COG0827	DNA restriction-modification system
D2B33_RS04515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D2B33_RS04520	COG0521	Mo-molybdopterin cofactor biosynthetic process
D2B33_RS04525	COG0137	argininosuccinate synthase activity
D2B33_RS04530	COG0165	Argininosuccinate lyase
D2B33_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS04540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D2B33_RS04545	COG1695	Transcriptional regulator
D2B33_RS04550	COG4109	DRTGG domain
D2B33_RS04560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D2B33_RS04580	COG0587	DNA-directed DNA polymerase activity
D2B33_RS04585	COG0281	malic enzyme
D2B33_RS04590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D2B33_RS04595	COG0825	malonyl-CoA metabolic process
D2B33_RS04600	COG0205	6-phosphofructokinase activity
D2B33_RS04610	COG3030	protein affecting phage T7 exclusion by the F plasmid
D2B33_RS04615	COG0628	permease
D2B33_RS04620	COG2707	UPF0756 membrane protein
D2B33_RS04630	COG2273	Hydrolase Family 16
D2B33_RS04635	COG0372	Belongs to the citrate synthase family
D2B33_RS04640	COG0538	isocitrate dehydrogenase activity
D2B33_RS04645	COG0039	L-malate dehydrogenase activity
D2B33_RS04650	COG0745	RESPONSE REGULATOR receiver
D2B33_RS04655	COG5002	protein histidine kinase activity
D2B33_RS04660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_RS04660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_RS04665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D2B33_RS04670	COG1971	Probably functions as a manganese efflux pump
D2B33_RS04675	COG0237	dephospho-CoA kinase activity
D2B33_RS04680	COG3866	Pectate lyase
D2B33_RS04685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2B33_RS04690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D2B33_RS04700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D2B33_RS04705	COG3611	Membrane attachment protein
D2B33_RS04710	COG1484	DNA-dependent DNA replication
D2B33_RS04715	COG0398	Pfam SNARE associated Golgi protein
D2B33_RS04725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2B33_RS04730	COG1011	Hydrolase
D2B33_RS04740	COG3275	phosphorelay sensor kinase activity
D2B33_RS04745	COG3279	Response regulator of the LytR AlgR family
D2B33_RS04750	COG3540	Alkaline phosphatase
D2B33_RS04760	COG1346	cytolysis
D2B33_RS04765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D2B33_RS04770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D2B33_RS04775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D2B33_RS04780	COG3326	Membrane
D2B33_RS04790	COG1363	Peptidase, m42
D2B33_RS04795	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS04800	COG2160	L-arabinose isomerase activity
D2B33_RS04805	COG1069	ribulokinase activity
D2B33_RS04810	COG0235	Class ii aldolase
D2B33_RS04815	COG0371	Dehydrogenase
D2B33_RS04820	COG1653	transport
D2B33_RS04825	COG1175	transmembrane transport
D2B33_RS04830	COG0395	ABC-type sugar transport system, permease component
D2B33_RS04850	COG3402	PFAM membrane-flanked domain
D2B33_RS04855	COG1309	transcriptional regulator
D2B33_RS04860	COG1966	Carbon starvation protein
D2B33_RS04870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2B33_RS04875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D2B33_RS04880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_RS04880	COG0072	phenylalanine-tRNA ligase activity
D2B33_RS04900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D2B33_RS04905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D2B33_RS04910	COG1286	toxin biosynthetic process
D2B33_RS04915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2B33_RS04915	COG1796	DNA polymerase
D2B33_RS04920	COG1193	negative regulation of DNA recombination
D2B33_RS04925	COG3766	membrane
D2B33_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS04935	COG1309	transcriptional regulator
D2B33_RS04940	COG1024	Enoyl-CoA hydratase
D2B33_RS04945	COG2086	electron transfer activity
D2B33_RS04950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D2B33_RS04955	COG3118	belongs to the thioredoxin family
D2B33_RS04960	COG0322	excinuclease ABC activity
D2B33_RS04965	COG0527	aspartate kinase activity
D2B33_RS04970	COG1719	4-vinyl reductase, 4VR
D2B33_RS04975	COG2009	succinate dehydrogenase
D2B33_RS04980	COG1053	succinate dehydrogenase
D2B33_RS04985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D2B33_RS04990	COG0824	Thioesterase
D2B33_RS04995	COG4221	oxidoreductase activity
D2B33_RS05000	COG2197	response regulator
D2B33_RS05005	COG1846	Transcriptional regulator
D2B33_RS05010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D2B33_RS05015	COG5401	PFAM Sporulation and spore germination
D2B33_RS05020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D2B33_RS05025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D2B33_RS05030	COG0622	Phosphoesterase
D2B33_RS05050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2B33_RS05060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_RS05065	COG0028	Belongs to the TPP enzyme family
D2B33_RS05070	COG0440	acetolactate synthase activity
D2B33_RS05075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D2B33_RS05080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D2B33_RS05085	COG0473	3-isopropylmalate dehydrogenase activity
D2B33_RS05090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D2B33_RS05095	COG0066	3-isopropylmalate dehydratase activity
D2B33_RS05100	COG0457	Tetratricopeptide repeat
D2B33_RS05100	COG1477	protein flavinylation
D2B33_RS05105	COG0544	peptidyl-prolyl cis-trans isomerase activity
D2B33_RS05110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D2B33_RS05115	COG1067	ATP-dependent peptidase activity
D2B33_RS05115	COG0470	DNA polymerase III
D2B33_RS05120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D2B33_RS05125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D2B33_RS05135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D2B33_RS05140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2B33_RS05145	COG0181	hydroxymethylbilane synthase activity
D2B33_RS05150	COG1587	Uroporphyrinogen-III synthase
D2B33_RS05155	COG0113	porphobilinogen synthase activity
D2B33_RS05160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D2B33_RS05165	COG1388	LysM domain
D2B33_RS05170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2B33_RS05180	COG0525	valine-tRNA ligase activity
D2B33_RS05185	COG0285	dihydrofolate synthase activity
D2B33_RS05190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D2B33_RS05200	COG0424	maF-like protein
D2B33_RS05205	COG2003	Belongs to the UPF0758 family
D2B33_RS05220	COG1396	sequence-specific DNA binding
D2B33_RS05330	COG4626	Terminase
D2B33_RS05330	COG1802	Transcriptional regulator
D2B33_RS05405	COG1388	LysM domain
D2B33_RS05405	COG1705	Flagellar rod assembly protein muramidase FlgJ
D2B33_RS05410	COG5434	Belongs to the glycosyl hydrolase 28 family
D2B33_RS05480	COG1077	Cell shape determining protein MreB Mrl
D2B33_RS05490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D2B33_RS05495	COG0850	regulation of cytokinetic process
D2B33_RS05500	COG2894	cell division
D2B33_RS05505	COG0640	Transcriptional regulator
D2B33_RS05510	COG3832	glyoxalase III activity
D2B33_RS05515	COG0739	heme binding
D2B33_RS05520	COG1994	Peptidase M50
D2B33_RS05525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D2B33_RS05530	COG2868	ribosomal protein
D2B33_RS05535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D2B33_RS05540	COG3290	protein histidine kinase activity
D2B33_RS05545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D2B33_RS05550	COG4492	Belongs to the UPF0735 family
D2B33_RS05555	COG0077	Prephenate dehydratase
D2B33_RS05560	COG1827	regulation of RNA biosynthetic process
D2B33_RS05565	COG1104	cysteine desulfurase activity
D2B33_RS05570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D2B33_RS05575	COG0157	Belongs to the NadC ModD family
D2B33_RS05580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D2B33_RS05585	COG1388	LysM domain
D2B33_RS05595	COG0217	transcriptional regulatory protein
D2B33_RS05610	COG4195	phage-related replication protein
D2B33_RS05615	COG2318	DinB family
D2B33_RS05625	COG2112	serine threonine protein kinase
D2B33_RS05635	COG0632	four-way junction helicase activity
D2B33_RS05640	COG2255	four-way junction helicase activity
D2B33_RS05650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D2B33_RS05655	COG0343	queuine tRNA-ribosyltransferase activity
D2B33_RS05660	COG1862	Preprotein translocase
D2B33_RS05670	COG2323	membrane
D2B33_RS05675	COG2244	polysaccharide biosynthetic process
D2B33_RS05685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2B33_RS05685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2B33_RS05690	COG5416	Lipopolysaccharide assembly protein A domain
D2B33_RS05695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D2B33_RS05695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D2B33_RS05700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_RS05705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D2B33_RS05710	COG1490	D-aminoacyl-tRNA deacylase activity
D2B33_RS05715	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS05715	COG3103	Sh3 type 3 domain protein
D2B33_RS05715	COG4991	sh3 domain protein
D2B33_RS05720	COG0124	histidyl-tRNA synthetase
D2B33_RS05725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D2B33_RS05735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D2B33_RS05740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D2B33_RS05745	COG1959	2 iron, 2 sulfur cluster binding
D2B33_RS05750	COG1104	cysteine desulfurase activity
D2B33_RS05755	COG0482	sulfurtransferase activity
D2B33_RS05760	COG0457	Tetratricopeptide repeat
D2B33_RS05765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2B33_RS05770	COG3881	PFAM PRC-barrel domain
D2B33_RS05785	COG0628	permease
D2B33_RS05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D2B33_RS05795	COG4472	Bacterial protein of unknown function (DUF965)
D2B33_RS05800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D2B33_RS05805	COG3906	Belongs to the UPF0473 family
D2B33_RS05810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2B33_RS05815	COG4122	O-methyltransferase activity
D2B33_RS05820	COG0826	peptidase U32
D2B33_RS05825	COG0826	peptidase U32
D2B33_RS05830	COG0572	uridine kinase
D2B33_RS05835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D2B33_RS05840	COG0768	penicillin binding
D2B33_RS05855	COG2226	methyltransferase
D2B33_RS05860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D2B33_RS05865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_RS05870	COG0626	cystathionine gamma-synthase activity
D2B33_RS05895	COG2226	methyltransferase
D2B33_RS05900	COG1404	Belongs to the peptidase S8 family
D2B33_RS05905	COG1309	transcriptional regulator
D2B33_RS05910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2B33_RS05910	COG2124	cytochrome p450
D2B33_RS05920	COG2814	Major facilitator Superfamily
D2B33_RS05925	COG0583	DNA-binding transcription factor activity
D2B33_RS05930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS05940	COG1587	Uroporphyrinogen-III synthase
D2B33_RS05945	COG3340	Belongs to the peptidase S51 family
D2B33_RS05950	COG1733	regulation of RNA biosynthetic process
D2B33_RS05955	COG2814	Major facilitator Superfamily
D2B33_RS05960	COG0656	L-ascorbic acid biosynthetic process
D2B33_RS05970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D2B33_RS05975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D2B33_RS05985	COG2205	protein histidine kinase activity
D2B33_RS05990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2B33_RS05995	COG2169	Transcriptional regulator
D2B33_RS06015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D2B33_RS06015	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D2B33_RS06020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS06025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS06030	COG3715	PTS system
D2B33_RS06035	COG3716	PTS system mannose fructose sorbose family IID component
D2B33_RS06040	COG1621	beta-fructofuranosidase activity
D2B33_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS06055	COG2211	Major facilitator Superfamily
D2B33_RS06060	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS06065	COG0730	response to heat
D2B33_RS06070	COG2124	cytochrome p450
D2B33_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS06105	COG4608	Belongs to the ABC transporter superfamily
D2B33_RS06110	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS06115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS06120	COG0601	transmembrane transport
D2B33_RS06125	COG0747	negative chemotaxis
D2B33_RS06130	COG0492	ferredoxin-NADP+ reductase activity
D2B33_RS06135	COG2197	response regulator
D2B33_RS06140	COG4585	Histidine kinase
D2B33_RS06145	COG3239	Fatty acid desaturase
D2B33_RS06150	COG1733	regulation of RNA biosynthetic process
D2B33_RS06155	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D2B33_RS06160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D2B33_RS06165	COG1942	4-Oxalocrotonate Tautomerase
D2B33_RS06195	COG1937	Protein conserved in bacteria
D2B33_RS06200	COG2210	Belongs to the sulfur carrier protein TusA family
D2B33_RS06205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_RS06205	COG0425	Belongs to the sulfur carrier protein TusA family
D2B33_RS06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS06210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_RS06215	COG0425	Belongs to the sulfur carrier protein TusA family
D2B33_RS06220	COG0730	response to heat
D2B33_RS06225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS06230	COG4585	Histidine kinase
D2B33_RS06235	COG2197	response regulator
D2B33_RS06270	COG3226	Transcriptional regulator
D2B33_RS06280	COG2223	nitrite transmembrane transporter activity
D2B33_RS06285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D2B33_RS06290	COG1140	nitrate reductase beta subunit
D2B33_RS06295	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D2B33_RS06300	COG2181	nitrate reductase activity
D2B33_RS06310	COG2828	Protein conserved in bacteria
D2B33_RS06315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D2B33_RS06325	COG0789	Transcriptional regulator
D2B33_RS06325	COG4978	Transcriptional regulator
D2B33_RS06340	COG1486	melibiose metabolic process
D2B33_RS06345	COG0561	phosphatase activity
D2B33_RS06360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS06365	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_RS06370	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS06410	COG2427	Protein of unknown function (DUF1641)
D2B33_RS06415	COG3383	formate dehydrogenase (NAD+) activity
D2B33_RS06420	COG5609	conserved protein (DUF2294)
D2B33_RS06430	COG2755	lipolytic protein G-D-S-L family
D2B33_RS06440	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D2B33_RS06445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2B33_RS06450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D2B33_RS06455	COG1534	Rna-binding protein
D2B33_RS06460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D2B33_RS06465	COG1713	HD superfamily hydrolase involved in NAD metabolism
D2B33_RS06470	COG0799	negative regulation of ribosome biogenesis
D2B33_RS06475	COG2226	methyltransferase
D2B33_RS06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_RS06485	COG1555	photosystem II stabilization
D2B33_RS06485	COG1596	polysaccharide export
D2B33_RS06490	COG2131	deaminase
D2B33_RS06495	COG2333	competence protein COMEC
D2B33_RS06495	COG0658	competence protein
D2B33_RS06505	COG1466	dna polymerase III delta subunit
D2B33_RS06510	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS06515	COG1733	regulation of RNA biosynthetic process
D2B33_RS06525	COG0268	Binds directly to 16S ribosomal RNA
D2B33_RS06530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D2B33_RS06535	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS06545	COG0481	GTPase activity
D2B33_RS06550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2B33_RS06555	COG1420	regulation of RNA biosynthetic process
D2B33_RS06560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D2B33_RS06565	COG0443	Heat shock 70 kDa protein
D2B33_RS06570	COG0484	heat shock protein binding
D2B33_RS06575	COG2264	protein methyltransferase activity
D2B33_RS06580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D2B33_RS06585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D2B33_RS06590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D2B33_RS06595	COG1283	sodium-dependent phosphate transmembrane transporter activity
D2B33_RS06600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D2B33_RS06605	COG1610	YqeY-like protein
D2B33_RS06610	COG1030	water channel activity
D2B33_RS06615	COG4864	UPF0365 protein
D2B33_RS06630	COG0561	phosphatase activity
D2B33_RS06635	COG1702	phosphate starvation-inducible protein PhoH
D2B33_RS06640	COG1480	7TM receptor with intracellular HD hydrolase
D2B33_RS06645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D2B33_RS06650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D2B33_RS06655	COG0295	cytidine deaminase activity
D2B33_RS06660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D2B33_RS06670	COG1381	Involved in DNA repair and RecF pathway recombination
D2B33_RS06675	COG0752	glycyl-tRNA synthetase alpha subunit
D2B33_RS06680	COG0751	glycine-tRNA ligase activity
D2B33_RS06685	COG0517	IMP dehydrogenase activity
D2B33_RS06690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D2B33_RS06695	COG1671	Belongs to the UPF0178 family
D2B33_RS06700	COG0358	DNA primase activity
D2B33_RS06705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D2B33_RS06710	COG2010	Cytochrome c
D2B33_RS06725	COG5444	nuclease activity
D2B33_RS06750	COG2384	SAM-dependent methyltransferase
D2B33_RS06755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D2B33_RS06760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D2B33_RS06770	COG0513	Belongs to the DEAD box helicase family
D2B33_RS06775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D2B33_RS06785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS06790	COG1121	(ABC) transporter
D2B33_RS06795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2B33_RS06800	COG0735	belongs to the Fur family
D2B33_RS06805	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D2B33_RS06810	COG4709	membrane
D2B33_RS06815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D2B33_RS06820	COG1388	LysM domain
D2B33_RS06825	COG5521	maltodextrose utilization protein MalA
D2B33_RS06830	COG2839	Protein conserved in bacteria
D2B33_RS06835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2B33_RS06840	COG0477	Major facilitator Superfamily
D2B33_RS06845	COG0768	penicillin binding
D2B33_RS06850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D2B33_RS06855	COG0573	inorganic phosphate transmembrane transporter activity
D2B33_RS06860	COG0581	inorganic phosphate transmembrane transporter activity
D2B33_RS06865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2B33_RS06870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2B33_RS06920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2B33_RS06940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2B33_RS06945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D2B33_RS06950	COG0457	Tetratricopeptide repeat
D2B33_RS06950	COG0705	Rhomboid family
D2B33_RS06955	COG0697	spore germination
D2B33_RS06960	COG4483	Protein conserved in bacteria
D2B33_RS06965	COG1940	carbohydrate kinase activity
D2B33_RS06970	COG1368	sulfuric ester hydrolase activity
D2B33_RS06975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS06980	COG2866	Carboxypeptidase
D2B33_RS06990	COG0011	TIGRFAM Protein of
D2B33_RS07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS07010	COG1393	Belongs to the ArsC family
D2B33_RS07020	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_RS07025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D2B33_RS07030	COG1459	type II secretion system
D2B33_RS07035	COG4537	Required for transformation and DNA binding
D2B33_RS07040	COG4970	Tfp pilus assembly protein FimT
D2B33_RS07050	COG4940	Competence protein ComGF
D2B33_RS07075	COG0681	Belongs to the peptidase S26 family
D2B33_RS07100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2B33_RS07105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D2B33_RS07110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D2B33_RS07115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D2B33_RS07120	COG4175	Glycine betaine
D2B33_RS07120	COG0517	IMP dehydrogenase activity
D2B33_RS07125	COG4176	ABC-type proline glycine betaine transport system permease component
D2B33_RS07130	COG2113	Glycine betaine
D2B33_RS07135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_RS07140	COG0095	Lipoate-protein ligase
D2B33_RS07145	COG1321	iron dependent repressor
D2B33_RS07150	COG1752	Esterase of the alpha-beta hydrolase superfamily
D2B33_RS07160	COG3872	metal-dependent enzyme
D2B33_RS07170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D2B33_RS07175	COG0006	proline dipeptidase activity
D2B33_RS07180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D2B33_RS07190	COG3854	ATPases associated with a variety of cellular activities
D2B33_RS07230	COG0511	ligase activity, forming carbon-carbon bonds
D2B33_RS07235	COG0439	Biotin carboxylase
D2B33_RS07240	COG1302	Protein conserved in bacteria
D2B33_RS07245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2B33_RS07250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D2B33_RS07255	COG1570	exodeoxyribonuclease VII activity
D2B33_RS07260	COG1722	exodeoxyribonuclease VII activity
D2B33_RS07265	COG0142	geranyltranstransferase activity
D2B33_RS07270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D2B33_RS07275	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D2B33_RS07280	COG1438	arginine binding
D2B33_RS07285	COG0497	DNA recombination
D2B33_RS07290	COG0750	zinc metalloprotease
D2B33_RS07295	COG0745	RESPONSE REGULATOR receiver
D2B33_RS07315	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS07320	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_RS07330	COG3290	protein histidine kinase activity
D2B33_RS07330	COG3829	transcription factor binding
D2B33_RS07335	COG0280	phosphate acetyltransferase
D2B33_RS07345	COG3426	butyrate kinase activity
D2B33_RS07350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_RS07355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_RS07360	COG0022	dehydrogenase e1 component
D2B33_RS07365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_RS07370	COG1597	lipid kinase activity
D2B33_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_RS07390	COG0765	amino acid transport
D2B33_RS07395	COG1126	abc transporter atp-binding protein
D2B33_RS07400	COG4129	membrane
D2B33_RS07410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2B33_RS07415	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2B33_RS07420	COG0706	membrane insertase activity
D2B33_RS07430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2B33_RS07435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D2B33_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS07445	COG1785	Belongs to the alkaline phosphatase family
D2B33_RS07450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS07455	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_RS07460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS07465	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS07470	COG2188	Transcriptional regulator
D2B33_RS07475	COG2358	TRAP transporter, solute receptor (TAXI family
D2B33_RS07490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D2B33_RS07495	COG1234	tRNA 3'-trailer cleavage
D2B33_RS07500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2B33_RS07505	COG0596	Alpha beta hydrolase
D2B33_RS07510	COG1902	pentaerythritol trinitrate reductase activity
D2B33_RS07515	COG4187	Peptidase family M20/M25/M40
D2B33_RS07520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_RS07525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS07530	COG0300	oxidoreductase activity
D2B33_RS07535	COG4195	phage-related replication protein
D2B33_RS07545	COG2814	Major facilitator Superfamily
D2B33_RS07550	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D2B33_RS07570	COG0745	RESPONSE REGULATOR receiver
D2B33_RS07575	COG2205	protein histidine kinase activity
D2B33_RS07600	COG1131	(ABC) transporter
D2B33_RS07610	COG1072	(Pantothenic acid kinase))
D2B33_RS07615	COG0346	lactoylglutathione lyase activity
D2B33_RS07620	COG2211	Major facilitator Superfamily
D2B33_RS07630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2B33_RS07645	COG0534	Mate efflux family protein
D2B33_RS07655	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS07665	COG0601	transmembrane transport
D2B33_RS07670	COG0747	negative chemotaxis
D2B33_RS07680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D2B33_RS07690	COG2329	Antibiotic biosynthesis monooxygenase
D2B33_RS07695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D2B33_RS07695	COG0456	acetyltransferase
D2B33_RS07705	COG4918	Iron-sulphur cluster biosynthesis
D2B33_RS07715	COG1073	alpha beta
D2B33_RS07725	COG0667	Aldo Keto reductase
D2B33_RS07735	COG1309	transcriptional regulator
D2B33_RS07745	COG0494	nUDIX hydrolase
D2B33_RS07750	COG1379	DNA repair
D2B33_RS07755	COG2153	protein acetylation
D2B33_RS07765	COG1953	Uracil, thiamine, allantoin
D2B33_RS07775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS07780	COG1300	Membrane
D2B33_RS07785	COG0735	belongs to the Fur family
D2B33_RS07795	COG4974	Belongs to the 'phage' integrase family
D2B33_RS07800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2B33_RS07805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D2B33_RS07810	COG1686	Belongs to the peptidase S11 family
D2B33_RS07845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_RS07860	COG0697	spore germination
D2B33_RS07870	COG0019	diaminopimelate decarboxylase activity
D2B33_RS07875	COG4195	phage-related replication protein
D2B33_RS07880	COG4086	secreted protein
D2B33_RS07885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D2B33_RS07890	COG0457	Tetratricopeptide repeat
D2B33_RS07910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2B33_RS07910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2B33_RS07915	COG0307	riboflavin synthase, alpha
D2B33_RS07920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D2B33_RS07920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D2B33_RS07925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D2B33_RS07930	COG0456	acetyltransferase
D2B33_RS07940	COG1547	Domain of unknown function (DUF309)
D2B33_RS07950	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D2B33_RS07955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D2B33_RS07965	COG1686	Belongs to the peptidase S11 family
D2B33_RS07970	COG2715	membrane protein required for spore maturation
D2B33_RS07975	COG0700	Nucleoside recognition
D2B33_RS07980	COG1187	pseudouridine synthase activity
D2B33_RS07985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS07990	COG1333	cytochrome c biogenesis protein
D2B33_RS07995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2B33_RS08000	COG0745	RESPONSE REGULATOR receiver
D2B33_RS08005	COG5002	protein histidine kinase activity
D2B33_RS08010	COG0745	RESPONSE REGULATOR receiver
D2B33_RS08015	COG5002	protein histidine kinase activity
D2B33_RS08030	COG1316	TRANSCRIPTIONal
D2B33_RS08035	COG1595	DNA-templated transcription, initiation
D2B33_RS08045	COG0739	heme binding
D2B33_RS08050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D2B33_RS08055	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D2B33_RS08060	COG1141	Ferredoxin
D2B33_RS08065	COG4955	Helix-turn-helix domain
D2B33_RS08070	COG0514	ATP-dependent DNA helicase (RecQ)
D2B33_RS08075	COG1266	CAAX protease self-immunity
D2B33_RS08080	COG1388	LysM domain
D2B33_RS08095	COG1408	metallophosphoesterase
D2B33_RS08100	COG4862	establishment of competence for transformation
D2B33_RS08105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2B33_RS08110	COG0492	ferredoxin-NADP+ reductase activity
D2B33_RS08120	COG2339	peptidase activity
D2B33_RS08125	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_RS08125	COG3773	Cell wall hydrolase
D2B33_RS08130	COG2959	enzyme of heme biosynthesis
D2B33_RS08135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D2B33_RS08140	COG0539	negative regulation of cytoplasmic translation
D2B33_RS08145	COG1304	FMN binding
D2B33_RS08170	COG1160	GTP binding
D2B33_RS08175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D2B33_RS08195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2B33_RS08200	COG0776	regulation of translation
D2B33_RS08215	COG0142	geranyltranstransferase activity
D2B33_RS08220	COG2226	methyltransferase
D2B33_RS08225	COG0142	geranyltranstransferase activity
D2B33_RS08230	COG0105	UTP biosynthetic process
D2B33_RS08235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D2B33_RS08240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D2B33_RS08245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D2B33_RS08250	COG4401	Chorismate mutase type I
D2B33_RS08255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_RS08260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D2B33_RS08265	COG0134	indole-3-glycerol-phosphate synthase activity
D2B33_RS08270	COG0135	phosphoribosylanthranilate isomerase activity
D2B33_RS08275	COG0133	tryptophan synthase activity
D2B33_RS08280	COG0159	tryptophan synthase activity
D2B33_RS08285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D2B33_RS08290	COG0287	Prephenate dehydrogenase
D2B33_RS08295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D2B33_RS08300	COG0457	Tetratricopeptide repeat
D2B33_RS08305	COG5582	Belongs to the UPF0302 family
D2B33_RS08315	COG0723	plastoquinol--plastocyanin reductase activity
D2B33_RS08320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2B33_RS08325	COG2010	Cytochrome c
D2B33_RS08325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2B33_RS08330	COG4347	Protein of unknown function (DUF1405)
D2B33_RS08340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS08345	COG1694	Mazg nucleotide pyrophosphohydrolase
D2B33_RS08350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D2B33_RS08355	COG1803	Methylglyoxal synthase
D2B33_RS08360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_RS08365	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS08370	COG0617	tRNA 3'-terminal CCA addition
D2B33_RS08380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D2B33_RS08385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D2B33_RS08390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D2B33_RS08395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D2B33_RS08395	COG1199	ATP-dependent helicase activity
D2B33_RS08405	COG5353	protein conserved in bacteria
D2B33_RS08410	COG0436	Aminotransferase
D2B33_RS08415	COG0017	Asparaginyl-tRNA synthetase
D2B33_RS08420	COG3935	DnaD domain protein
D2B33_RS08425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D2B33_RS08435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_RS08435	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2B33_RS08440	COG3331	DNA recombination
D2B33_RS08475	COG0071	Belongs to the small heat shock protein (HSP20) family
D2B33_RS08480	COG2190	(PTS) system
D2B33_RS08485	COG1205	dead DEAH box helicase
D2B33_RS08485	COG1111	helicase
D2B33_RS08490	COG3359	exonuclease
D2B33_RS08500	COG4474	Belongs to the UPF0398 family
D2B33_RS08505	COG3599	regulation of cell shape
D2B33_RS08515	COG0116	Belongs to the methyltransferase superfamily
D2B33_RS08535	COG1199	ATP-dependent helicase activity
D2B33_RS08540	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D2B33_RS08545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_RS08550	COG2233	PERMEase
D2B33_RS08560	COG3424	synthase
D2B33_RS08565	COG1755	Isoprenylcysteine carboxyl methyltransferase
D2B33_RS08575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2B33_RS08585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_RS08595	COG0328	RNA-DNA hybrid ribonuclease activity
D2B33_RS08600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D2B33_RS08605	COG0328	RNA-DNA hybrid ribonuclease activity
D2B33_RS08625	COG1278	Cold shock
D2B33_RS08635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_RS08640	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D2B33_RS08645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D2B33_RS08650	COG0386	Belongs to the glutathione peroxidase family
D2B33_RS08660	COG1413	lyase activity
D2B33_RS08665	COG0129	dihydroxy-acid dehydratase activity
D2B33_RS08675	COG2136	Putative SAM-dependent methyltransferase
D2B33_RS08675	COG2521	methyltransferase
D2B33_RS08685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D2B33_RS08690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2B33_RS08695	COG0204	Acyl-transferase
D2B33_RS08700	COG1272	protein, Hemolysin III
D2B33_RS08705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D2B33_RS08710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D2B33_RS08725	COG1999	signal sequence binding
D2B33_RS08730	COG2755	lipolytic protein G-D-S-L family
D2B33_RS08735	COG4698	Protein conserved in bacteria
D2B33_RS08750	COG0534	Mate efflux family protein
D2B33_RS08755	COG3706	GGDEF domain
D2B33_RS08765	COG1846	Transcriptional regulator
D2B33_RS08770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2B33_RS08775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2B33_RS08790	COG0456	acetyltransferase
D2B33_RS08805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2B33_RS08810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D2B33_RS08815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D2B33_RS08820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_RS08825	COG0456	acetyltransferase
D2B33_RS08830	COG1509	lysine 2,3-aminomutase activity
D2B33_RS08840	COG4479	Belongs to the UPF0346 family
D2B33_RS08855	COG0671	phosphoesterase, PA-phosphatase related
D2B33_RS08875	COG0701	Predicted permease
D2B33_RS08880	COG0813	purine-nucleoside phosphorylase activity
D2B33_RS08885	COG1876	peptidase activity
D2B33_RS08895	COG2226	methyltransferase
D2B33_RS08900	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_RS08900	COG0793	Belongs to the peptidase S41A family
D2B33_RS08905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS08915	COG0400	carboxylic ester hydrolase activity
D2B33_RS08920	COG0778	Nitroreductase
D2B33_RS08925	COG1733	regulation of RNA biosynthetic process
D2B33_RS08940	COG4305	rare lipoprotein A
D2B33_RS08950	COG2962	Rard protein
D2B33_RS08960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_RS08965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_RS08970	COG0534	Mate efflux family protein
D2B33_RS08975	COG1388	LysM domain
D2B33_RS08975	COG0791	NLP P60 protein
D2B33_RS08980	COG2032	superoxide dismutase activity
D2B33_RS08985	COG0714	Associated with various cellular activities
D2B33_RS08990	COG4548	von Willebrand factor, type A
D2B33_RS08995	COG0567	Dehydrogenase, E1 component
D2B33_RS09000	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_RS09005	COG0385	Bile acid
D2B33_RS09010	COG0733	neurotransmitter:sodium symporter activity
D2B33_RS09020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2B33_RS09025	COG1657	PFAM Prenyltransferase squalene oxidase
D2B33_RS09045	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS09060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_RS09080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2B33_RS09085	COG2318	DinB family
D2B33_RS09105	COG3848	Pyruvate phosphate dikinase
D2B33_RS09105	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_RS09115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_RS09120	COG1280	lysine exporter protein (LysE YggA)
D2B33_RS09135	COG2267	carboxylic ester hydrolase activity
D2B33_RS09150	COG0402	S-adenosylhomocysteine deaminase activity
D2B33_RS09170	COG2350	Protein conserved in bacteria
D2B33_RS09195	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D2B33_RS09205	COG5444	nuclease activity
D2B33_RS09220	COG3383	formate dehydrogenase (NAD+) activity
D2B33_RS09225	COG2427	Protein of unknown function (DUF1641)
D2B33_RS09235	COG2315	Protein conserved in bacteria
D2B33_RS09255	COG0514	ATP-dependent DNA helicase (RecQ)
D2B33_RS09260	COG1388	LysM domain
D2B33_RS09260	COG3584	3D domain protein
D2B33_RS09265	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS09270	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2B33_RS09285	COG2322	membrane
D2B33_RS09290	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS09305	COG1086	Polysaccharide biosynthesis protein
D2B33_RS09310	COG0741	lytic transglycosylase activity
D2B33_RS09315	COG0531	amino acid
D2B33_RS09330	COG0640	Transcriptional regulator
D2B33_RS09340	COG2378	regulation of single-species biofilm formation
D2B33_RS09350	COG3708	Transcriptional regulator
D2B33_RS09355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS09360	COG1309	transcriptional regulator
D2B33_RS09390	COG1846	Transcriptional regulator
D2B33_RS09395	COG1309	transcriptional regulator
D2B33_RS09405	COG1404	Belongs to the peptidase S8 family
D2B33_RS09410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_RS09415	COG0840	transmembrane signaling receptor activity
D2B33_RS09420	COG0488	(ABC) transporter
D2B33_RS09425	COG0697	spore germination
D2B33_RS09430	COG0531	amino acid
D2B33_RS09435	COG0531	amino acid
D2B33_RS09445	COG0531	amino acid
D2B33_RS09450	COG2814	Major facilitator Superfamily
D2B33_RS09455	COG1846	Transcriptional regulator
D2B33_RS09460	COG0243	molybdopterin cofactor binding
D2B33_RS09465	COG0477	Major facilitator Superfamily
D2B33_RS09470	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_RS09470	COG3848	Pyruvate phosphate dikinase
D2B33_RS09475	COG0300	oxidoreductase activity
D2B33_RS09485	COG1132	(ABC) transporter
D2B33_RS09515	COG0583	DNA-binding transcription factor activity
D2B33_RS09520	COG0069	glutamate synthase activity
D2B33_RS09520	COG0067	glutamate synthase
D2B33_RS09520	COG0070	glutamate synthase
D2B33_RS09525	COG0493	'glutamate synthase
D2B33_RS09540	COG0463	Glycosyl transferase, family 2
D2B33_RS09545	COG2814	Major facilitator Superfamily
D2B33_RS09550	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_RS09555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS09560	COG1809	phosphosulfolactate synthase activity
D2B33_RS09565	COG0175	sulfate reduction
D2B33_RS09570	COG0306	phosphate transporter
D2B33_RS09575	COG2323	membrane
D2B33_RS09585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2B33_RS09590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D2B33_RS09595	COG1733	regulation of RNA biosynthetic process
D2B33_RS09600	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS09605	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS09615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS09620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS09625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS09635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS09635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D2B33_RS09640	COG0439	Biotin carboxylase
D2B33_RS09645	COG0511	ligase activity, forming carbon-carbon bonds
D2B33_RS09650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D2B33_RS09655	COG1024	Enoyl-CoA hydratase
D2B33_RS09660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2B33_RS09665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_RS09675	COG0166	Belongs to the GPI family
D2B33_RS09690	COG1252	NADH dehydrogenase
D2B33_RS09695	COG1309	transcriptional regulator
D2B33_RS09715	COG2027	D-alanyl-D-alanine carboxypeptidase
D2B33_RS09720	COG0438	transferase activity, transferring glycosyl groups
D2B33_RS09730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D2B33_RS09735	COG2404	hydrolase activity, acting on ester bonds
D2B33_RS09740	COG1649	PFAM Uncharacterised BCR, COG1649
D2B33_RS09755	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D2B33_RS09760	COG0640	Transcriptional regulator
D2B33_RS09765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D2B33_RS09770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_RS09775	COG1609	Transcriptional regulator
D2B33_RS09785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D2B33_RS09800	COG1312	Catalyzes the dehydration of D-mannonate
D2B33_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS09810	COG1725	Transcriptional regulator
D2B33_RS09825	COG3711	transcriptional antiterminator
D2B33_RS09825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS09840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS09840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS09840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS09845	COG1482	cell wall glycoprotein biosynthetic process
D2B33_RS09850	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS09855	COG2084	Dehydrogenase
D2B33_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS09865	COG1024	Enoyl-CoA hydratase
D2B33_RS09895	COG1114	Component of the transport system for branched-chain amino acids
D2B33_RS09900	COG3420	alginic acid biosynthetic process
D2B33_RS09915	COG0492	ferredoxin-NADP+ reductase activity
D2B33_RS09935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D2B33_RS09945	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D2B33_RS09965	COG2223	nitrite transmembrane transporter activity
D2B33_RS09970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2B33_RS09980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2B33_RS09985	COG0535	radical SAM domain protein
D2B33_RS10000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D2B33_RS10005	COG1140	nitrate reductase beta subunit
D2B33_RS10010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D2B33_RS10015	COG2181	nitrate reductase activity
D2B33_RS10025	COG1115	amino acid carrier protein
D2B33_RS10045	COG2160	L-arabinose isomerase activity
D2B33_RS10060	COG1609	Transcriptional regulator
D2B33_RS10065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2B33_RS10070	COG0187	DNA topoisomerase II activity
D2B33_RS10075	COG1832	CoA-binding protein
D2B33_RS10080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D2B33_RS10085	COG4841	protein insertion into membrane
D2B33_RS10105	COG0824	Thioesterase
D2B33_RS10125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS10130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D2B33_RS10145	COG0071	Belongs to the small heat shock protein (HSP20) family
D2B33_RS10155	COG4846	Membrane protein involved in cytochrome C biogenesis
D2B33_RS10160	COG2201	protein-glutamate methylesterase activity
D2B33_RS10165	COG0785	Cytochrome C biogenesis protein
D2B33_RS10175	COG3763	UPF0154 protein
D2B33_RS10185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D2B33_RS10190	COG4224	UPF0291 protein
D2B33_RS10195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D2B33_RS10200	COG1388	LysM domain
D2B33_RS10205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D2B33_RS10210	COG3209	COG3209 Rhs family protein
D2B33_RS10230	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS10235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D2B33_RS10240	COG0346	lactoylglutathione lyase activity
D2B33_RS10245	COG1846	Transcriptional regulator
D2B33_RS10270	COG3546	catalase activity
D2B33_RS10275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS10290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_RS10295	COG2076	Multidrug Resistance protein
D2B33_RS10300	COG2076	Multidrug Resistance protein
D2B33_RS10305	COG1309	transcriptional regulator
D2B33_RS10345	COG1073	alpha beta
D2B33_RS10355	COG0475	glutathione-regulated potassium exporter activity
D2B33_RS10360	COG0490	domain, Protein
D2B33_RS10410	COG0174	glutamine synthetase
D2B33_RS10415	COG0789	Transcriptional regulator
D2B33_RS10420	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D2B33_RS10425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D2B33_RS10430	COG0464	growth
D2B33_RS10450	COG1695	Transcriptional regulator
D2B33_RS10460	COG0829	nickel cation binding
D2B33_RS10465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D2B33_RS10470	COG0830	nickel cation binding
D2B33_RS10475	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D2B33_RS10485	COG0832	Belongs to the urease beta subunit family
D2B33_RS10490	COG0831	urea catabolic process
D2B33_RS10495	COG4413	Urea transporter
D2B33_RS10505	COG2732	(Barnase) inhibitor
D2B33_RS10525	COG0457	Tetratricopeptide repeat
D2B33_RS10530	COG2814	Major facilitator Superfamily
D2B33_RS10565	COG1309	transcriptional regulator
D2B33_RS10595	COG0697	spore germination
D2B33_RS10600	COG1802	Transcriptional regulator
D2B33_RS10620	COG4112	unkown
D2B33_RS10625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_RS10630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_RS10635	COG1780	Probably involved in ribonucleotide reductase function
D2B33_RS10645	COG1923	regulation of RNA biosynthetic process
D2B33_RS10650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D2B33_RS10665	COG2076	Multidrug Resistance protein
D2B33_RS10670	COG2076	Multidrug Resistance protein
D2B33_RS10675	COG1764	response to oxidative stress
D2B33_RS10685	COG0702	epimerase
D2B33_RS10690	COG3631	Ketosteroid isomerase-related protein
D2B33_RS10695	COG1309	transcriptional regulator
D2B33_RS10700	COG1388	LysM domain
D2B33_RS10700	COG3858	chitin binding
D2B33_RS10710	COG5577	PFAM Coat F domain
D2B33_RS10715	COG0531	amino acid
D2B33_RS10720	COG1819	glycosyl
D2B33_RS10725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_RS10730	COG0398	Pfam SNARE associated Golgi protein
D2B33_RS10735	COG0393	Putative heavy-metal-binding
D2B33_RS10745	COG2814	Major facilitator Superfamily
D2B33_RS10750	COG3263	regulation of cellular component size
D2B33_RS10755	COG3619	membrane
D2B33_RS10760	COG1231	oxidoreductase activity
D2B33_RS10780	COG0523	cobalamin synthesis protein
D2B33_RS10795	COG0457	Tetratricopeptide repeat
D2B33_RS10810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2B33_RS10815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D2B33_RS10820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D2B33_RS10830	COG4550	Control of competence regulator ComK, YlbF/YmcA
D2B33_RS10835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D2B33_RS10845	COG1063	alcohol dehydrogenase
D2B33_RS10855	COG2359	stage V sporulation protein S
D2B33_RS10860	COG1692	metallophosphoesterase
D2B33_RS10865	COG1418	mRNA catabolic process
D2B33_RS10875	COG1058	Belongs to the CinA family
D2B33_RS10875	COG1546	Belongs to the CinA family
D2B33_RS10880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D2B33_RS10885	COG1426	Protein conserved in bacteria
D2B33_RS10900	COG0300	oxidoreductase activity
D2B33_RS10905	COG0612	Peptidase, M16
D2B33_RS10910	COG0612	Peptidase, M16
D2B33_RS10915	COG2814	Major facilitator Superfamily
D2B33_RS10920	COG2188	Transcriptional regulator
D2B33_RS10925	COG4980	gas vesicle protein
D2B33_RS10925	COG1674	ftsk spoiiie
D2B33_RS10935	COG0740	serine-type endopeptidase activity
D2B33_RS10940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2B33_RS10950	COG0527	aspartate kinase activity
D2B33_RS10955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D2B33_RS10960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2B33_RS10965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_RS10970	COG1873	PFAM PRC-barrel domain
D2B33_RS10975	COG0612	Peptidase, M16
D2B33_RS10980	COG0726	polysaccharide deacetylase
D2B33_RS10985	COG1185	polyribonucleotide nucleotidyltransferase activity
D2B33_RS10990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D2B33_RS10995	COG0196	riboflavin kinase activity
D2B33_RS11000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D2B33_RS11005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D2B33_RS11010	COG1550	Protein conserved in bacteria
D2B33_RS11015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D2B33_RS11020	COG1358	cellular component organization or biogenesis
D2B33_RS11025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D2B33_RS11030	COG0195	Participates in both transcription termination and antitermination
D2B33_RS11035	COG0779	Required for maturation of 30S ribosomal subunits
D2B33_RS11060	COG2176	DNA-directed DNA polymerase activity
D2B33_RS11065	COG0442	prolyl-tRNA aminoacylation
D2B33_RS11070	COG0750	zinc metalloprotease
D2B33_RS11075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D2B33_RS11080	COG4589	Belongs to the CDS family
D2B33_RS11085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D2B33_RS11090	COG0233	cytoplasmic translational termination
D2B33_RS11095	COG0528	UMP kinase activity
D2B33_RS11100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D2B33_RS11105	COG0052	Belongs to the universal ribosomal protein uS2 family
D2B33_RS11115	COG1191	sigma factor activity
D2B33_RS11120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D2B33_RS11125	COG1776	CheC inhibitor of MCP methylation
D2B33_RS11130	COG0835	chemotaxis
D2B33_RS11135	COG2198	Histidine kinase
D2B33_RS11135	COG0643	Histidine kinase
D2B33_RS11140	COG2201	protein-glutamate methylesterase activity
D2B33_RS11145	COG0455	bacterial-type flagellum organization
D2B33_RS11150	COG1419	protein localization to endoplasmic reticulum
D2B33_RS11155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2B33_RS11160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2B33_RS11165	COG1684	flagellar biosynthetic protein fliR
D2B33_RS11170	COG1987	bacterial-type flagellum assembly
D2B33_RS11175	COG1338	Plays a role in the flagellum-specific transport system
D2B33_RS11180	COG3190	flagellar
D2B33_RS11185	COG2201	protein-glutamate methylesterase activity
D2B33_RS11190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_RS11190	COG1776	CheC inhibitor of MCP methylation
D2B33_RS11195	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_RS11200	COG1580	Controls the rotational direction of flagella during chemotaxis
D2B33_RS11205	COG1582	Flagellar protein (FlbD)
D2B33_RS11210	COG4786	Flagellar basal body rod
D2B33_RS11215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D2B33_RS11220	COG3144	bacterial-type flagellum assembly
D2B33_RS11230	COG2882	bacterial-type flagellum organization
D2B33_RS11235	COG1157	protein secretion by the type III secretion system
D2B33_RS11240	COG1317	bacterial-type flagellum organization
D2B33_RS11245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_RS11255	COG1677	Flagellar hook-basal body complex protein FliE
D2B33_RS11260	COG1558	bacterial-type flagellum-dependent cell motility
D2B33_RS11265	COG1815	bacterial-type flagellum-dependent cell motility
D2B33_RS11270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2B33_RS11275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D2B33_RS11280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D2B33_RS11285	COG4974	Belongs to the 'phage' integrase family
D2B33_RS11290	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D2B33_RS11295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2B33_RS11300	COG0758	DNA mediated transformation
D2B33_RS11305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_RS11310	COG0045	succinate-CoA ligase (ADP-forming) activity
D2B33_RS11315	COG2257	FlhB HrpN YscU SpaS Family
D2B33_RS11325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D2B33_RS11330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2B33_RS11335	COG0335	large ribosomal subunit rRNA binding
D2B33_RS11340	COG0336	Belongs to the RNA methyltransferase TrmD family
D2B33_RS11345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D2B33_RS11355	COG1837	Belongs to the UPF0109 family
D2B33_RS11360	COG0228	four-way junction DNA binding
D2B33_RS11365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D2B33_RS11370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D2B33_RS11375	COG0552	protein localization to endoplasmic reticulum
D2B33_RS11380	COG1196	nuclear chromosome segregation
D2B33_RS11385	COG0571	ribonuclease III activity
D2B33_RS11390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2B33_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS11400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D2B33_RS11405	COG0416	fatty acid biosynthetic process
D2B33_RS11410	COG1349	DNA-binding transcription factor activity
D2B33_RS11415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D2B33_RS11420	COG1760	l-serine dehydratase
D2B33_RS11425	COG1760	l-serine dehydratase
D2B33_RS11430	COG1461	Dihydroxyacetone kinase
D2B33_RS11435	COG1302	Protein conserved in bacteria
D2B33_RS11440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D2B33_RS11450	COG1564	THIamine pyrophosphokinase
D2B33_RS11455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D2B33_RS11460	COG1162	GTPase activity
D2B33_RS11465	COG2815	serine threonine protein kinase
D2B33_RS11465	COG0515	serine threonine protein kinase
D2B33_RS11470	COG0631	protein serine/threonine phosphatase activity
D2B33_RS11475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D2B33_RS11480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2B33_RS11480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D2B33_RS11485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D2B33_RS11490	COG0242	peptide deformylase activity
D2B33_RS11495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2B33_RS11500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2B33_RS11505	COG1758	RNA polymerase activity
D2B33_RS11510	COG0194	GDP metabolic process
D2B33_RS11515	COG2052	Domain of unknown function (DUF370)
D2B33_RS11520	COG1561	YicC-like family, N-terminal region
D2B33_RS11525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D2B33_RS11535	COG1648	precorrin-2 dehydrogenase activity
D2B33_RS11540	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D2B33_RS11545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2B33_RS11550	COG0529	Catalyzes the synthesis of activated sulfate
D2B33_RS11555	COG2046	Belongs to the sulfate adenylyltransferase family
D2B33_RS11560	COG0306	phosphate transporter
D2B33_RS11565	COG0175	sulfate reduction
D2B33_RS11575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D2B33_RS11580	COG0284	orotidine-5'-phosphate decarboxylase activity
D2B33_RS11585	COG0167	dihydroorotate dehydrogenase activity
D2B33_RS11590	COG0543	2 iron, 2 sulfur cluster binding
D2B33_RS11595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2B33_RS11600	COG0505	Belongs to the CarA family
D2B33_RS11605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D2B33_RS11610	COG0540	Belongs to the ATCase OTCase family
D2B33_RS11615	COG2233	PERMEase
D2B33_RS11625	COG0564	pseudouridine synthase activity
D2B33_RS11630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D2B33_RS11635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_RS11640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D2B33_RS11645	COG3599	regulation of cell shape
D2B33_RS11650	COG2302	S4 RNA-binding domain
D2B33_RS11655	COG0762	integral membrane protein
D2B33_RS11660	COG1799	cell septum assembly
D2B33_RS11665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D2B33_RS11670	COG1496	oxidoreductase activity
D2B33_RS11675	COG1873	PFAM PRC-barrel domain
D2B33_RS11680	COG0500	methyltransferase
D2B33_RS11685	COG1119	ATPase activity
D2B33_RS11690	COG1191	sigma factor activity
D2B33_RS11695	COG1191	sigma factor activity
D2B33_RS11705	COG1404	Belongs to the peptidase S8 family
D2B33_RS11705	COG4412	M6 family metalloprotease domain protein
D2B33_RS11710	COG1404	Belongs to the peptidase S8 family
D2B33_RS11710	COG4412	M6 family metalloprotease domain protein
D2B33_RS11715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D2B33_RS11720	COG0849	cell division
D2B33_RS11725	COG3856	small basic protein
D2B33_RS11730	COG3879	Bacterial protein of unknown function (DUF881)
D2B33_RS11735	COG3879	Bacterial protein of unknown function (DUF881)
D2B33_RS11740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D2B33_RS11745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D2B33_RS11750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_RS11755	COG0772	Belongs to the SEDS family
D2B33_RS11760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D2B33_RS11765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2B33_RS11770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D2B33_RS11775	COG0768	penicillin binding
D2B33_RS11780	COG0768	penicillin binding
D2B33_RS11785	COG4839	cell division protein FtsL
D2B33_RS11790	COG0275	rRNA processing
D2B33_RS11795	COG2001	Belongs to the MraZ family
D2B33_RS11800	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D2B33_RS11805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D2B33_RS11810	COG0454	-acetyltransferase
D2B33_RS11820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D2B33_RS11825	COG1399	metal-binding, possibly nucleic acid-binding protein
D2B33_RS11830	COG1323	Belongs to the UPF0348 family
D2B33_RS11835	COG3480	Lon protease (S16) C-terminal proteolytic domain
D2B33_RS11840	COG3314	Sporulation integral membrane protein YlbJ
D2B33_RS11845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D2B33_RS11850	COG0742	ribosomal rna small subunit methyltransferase
D2B33_RS11855	COG4471	UPF0298 protein
D2B33_RS11860	COG3679	Belongs to the UPF0342 family
D2B33_RS11875	COG2340	Cysteine-rich secretory protein family
D2B33_RS11890	COG3336	cytochrome c oxidase
D2B33_RS11895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D2B33_RS11900	COG1845	cytochrome c oxidase, subunit III
D2B33_RS11905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2B33_RS11910	COG2010	Cytochrome c
D2B33_RS11910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2B33_RS11915	COG0109	protoheme IX farnesyltransferase activity
D2B33_RS11920	COG1612	heme a metabolic process
D2B33_RS11925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D2B33_RS11930	COG0772	Belongs to the SEDS family
D2B33_RS11935	COG4838	Belongs to the UPF0358 family
D2B33_RS11940	COG2066	Belongs to the glutaminase family
D2B33_RS11945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2B33_RS11950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D2B33_RS11960	COG4896	Protein conserved in bacteria
D2B33_RS11965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D2B33_RS11970	COG1846	Transcriptional regulator
D2B33_RS11980	COG1217	gtp-binding protein TYPA
D2B33_RS11995	COG1595	DNA-templated transcription, initiation
D2B33_RS12015	COG0483	inositol monophosphate 1-phosphatase activity
D2B33_RS12025	COG4493	Belongs to the UPF0637 family
D2B33_RS12030	COG4476	Belongs to the UPF0223 family
D2B33_RS12035	COG1982	Orn Lys Arg decarboxylase major
D2B33_RS12045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS12050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_RS12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_RS12060	COG0022	dehydrogenase e1 component
D2B33_RS12065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_RS12070	COG0497	DNA recombination
D2B33_RS12080	COG0242	peptide deformylase activity
D2B33_RS12085	COG0561	phosphatase activity
D2B33_RS12090	COG5503	Protein of unknown function (DUF1447)
D2B33_RS12095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2B33_RS12100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D2B33_RS12105	COG0569	domain protein
D2B33_RS12110	COG3852	Histidine kinase
D2B33_RS12115	COG2002	toxin-antitoxin pair type II binding
D2B33_RS12120	COG1077	Cell shape determining protein MreB Mrl
D2B33_RS12130	COG2309	aminopeptidase activity
D2B33_RS12140	COG0488	(ABC) transporter
D2B33_RS12160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS12160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS12160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_RS12165	COG1105	Belongs to the carbohydrate kinase PfkB family
D2B33_RS12170	COG1349	DNA-binding transcription factor activity
D2B33_RS12180	COG0577	efflux transmembrane transporter activity
D2B33_RS12185	COG1136	(ABC) transporter
D2B33_RS12190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D2B33_RS12200	COG1132	(ABC) transporter
D2B33_RS12205	COG1132	(ABC) transporter
D2B33_RS12215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D2B33_RS12220	COG0314	molybdopterin synthase activity
D2B33_RS12225	COG1763	Mo-molybdopterin cofactor biosynthetic process
D2B33_RS12230	COG0303	'Molybdopterin
D2B33_RS12235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2B33_RS12240	COG0746	molybdenum cofactor guanylyltransferase activity
D2B33_RS12255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS12260	COG0450	alkyl hydroperoxide reductase
D2B33_RS12270	COG1473	amidohydrolase
D2B33_RS12275	COG2171	N-acyltransferase activity
D2B33_RS12280	COG0716	FMN binding
D2B33_RS12290	COG0716	FMN binding
D2B33_RS12295	COG0583	DNA-binding transcription factor activity
D2B33_RS12300	COG0517	IMP dehydrogenase activity
D2B33_RS12310	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D2B33_RS12315	COG4703	Protein of unknown function (DUF1797)
D2B33_RS12325	COG2200	EAL domain
D2B33_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS12335	COG1408	metallophosphoesterase
D2B33_RS12340	COG1376	ErfK ybiS ycfS ynhG family protein
D2B33_RS12345	COG2814	Major facilitator Superfamily
D2B33_RS12355	COG0784	Response regulator, receiver
D2B33_RS12355	COG0835	chemotaxis
D2B33_RS12365	COG1714	RDD family
D2B33_RS12370	COG0436	Aminotransferase
D2B33_RS12375	COG4191	Histidine kinase
D2B33_RS12380	COG0768	penicillin binding
D2B33_RS12385	COG2340	Cysteine-rich secretory protein family
D2B33_RS12390	COG2084	Dehydrogenase
D2B33_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS12400	COG0840	transmembrane signaling receptor activity
D2B33_RS12405	COG0456	acetyltransferase
D2B33_RS12410	COG1533	DNA photolyase activity
D2B33_RS12420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D2B33_RS12425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS12430	COG2190	(PTS) system
D2B33_RS12430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS12430	COG1263	PTS System
D2B33_RS12435	COG3711	transcriptional antiterminator
D2B33_RS12440	COG1609	Transcriptional regulator
D2B33_RS12450	COG0006	proline dipeptidase activity
D2B33_RS12455	COG2217	Heavy metal translocating P-type atpase
D2B33_RS12460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS12465	COG2244	polysaccharide biosynthetic process
D2B33_RS12470	COG3773	Cell wall hydrolase
D2B33_RS12480	COG4873	Protein conserved in bacteria
D2B33_RS12515	COG3655	Transcriptional regulator
D2B33_RS12520	COG3739	integral membrane protein
D2B33_RS12530	COG0457	Tetratricopeptide repeat
D2B33_RS12535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D2B33_RS12540	COG0602	queuosine metabolic process
D2B33_RS12545	COG0720	synthase
D2B33_RS12550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D2B33_RS12555	COG3949	Membrane
D2B33_RS12560	COG0542	response to heat
D2B33_RS12565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2B33_RS12570	COG1360	Flagellar Motor Protein
D2B33_RS12575	COG1846	Transcriptional regulator
D2B33_RS12580	COG3852	Histidine kinase
D2B33_RS12590	COG3339	Conserved Protein
D2B33_RS12595	COG0346	lactoylglutathione lyase activity
D2B33_RS12600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D2B33_RS12605	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D2B33_RS12605	COG0235	Class ii aldolase
D2B33_RS12610	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D2B33_RS12610	COG0235	Class ii aldolase
D2B33_RS12615	COG1850	ribulose-bisphosphate carboxylase activity
D2B33_RS12620	COG0436	Aminotransferase
D2B33_RS12625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2B33_RS12630	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D2B33_RS12635	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D2B33_RS12640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2B33_RS12645	COG5002	protein histidine kinase activity
D2B33_RS12650	COG3594	Acyltransferase
D2B33_RS12665	COG0768	penicillin binding
D2B33_RS12670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2B33_RS12675	COG0501	Belongs to the peptidase M48B family
D2B33_RS12695	COG1191	sigma factor activity
D2B33_RS12700	COG0861	Integral membrane protein TerC family
D2B33_RS12705	COG0586	Pfam SNARE associated Golgi protein
D2B33_RS12710	COG3300	MHYT domain
D2B33_RS12710	COG5001	Diguanylate cyclase
D2B33_RS12715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D2B33_RS12720	COG3285	dna ligase
D2B33_RS12720	COG1793	dna ligase
D2B33_RS12725	COG1846	Transcriptional regulator
D2B33_RS12740	COG0789	Transcriptional regulator
D2B33_RS12750	COG2239	Acts as a magnesium transporter
D2B33_RS12760	COG1404	Belongs to the peptidase S8 family
D2B33_RS12765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2B33_RS12780	COG0406	alpha-ribazole phosphatase activity
D2B33_RS12785	COG0590	tRNA wobble adenosine to inosine editing
D2B33_RS12795	COG1764	response to oxidative stress
D2B33_RS12800	COG1846	Transcriptional regulator
D2B33_RS12805	COG1764	response to oxidative stress
D2B33_RS12810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D2B33_RS12815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2B33_RS12820	COG0788	formyltetrahydrofolate deformylase activity
D2B33_RS12825	COG2076	Multidrug Resistance protein
D2B33_RS12830	COG2076	Multidrug Resistance protein
D2B33_RS12835	COG2318	DinB family
D2B33_RS12855	COG3866	Pectate lyase
D2B33_RS12860	COG2323	membrane
D2B33_RS12865	COG1607	acyl-coa hydrolase
D2B33_RS12870	COG1834	amidinotransferase
D2B33_RS12880	COG4608	Belongs to the ABC transporter superfamily
D2B33_RS12885	COG0791	NLP P60 protein
D2B33_RS12890	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_RS12895	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2B33_RS12900	COG4166	transmembrane transport
D2B33_RS12905	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS12910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS12915	COG0601	transmembrane transport
D2B33_RS12920	COG2362	D-Aminopeptidase
D2B33_RS12930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_RS12935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_RS12940	COG0346	lactoylglutathione lyase activity
D2B33_RS12945	COG0531	amino acid
D2B33_RS12950	COG0395	ABC-type sugar transport system, permease component
D2B33_RS12955	COG4209	transmembrane transport
D2B33_RS12960	COG1653	transport
D2B33_RS12970	COG1874	Beta-galactosidase
D2B33_RS12975	COG2755	lipolytic protein G-D-S-L family
D2B33_RS12980	COG0667	Aldo Keto reductase
D2B33_RS12985	COG3401	FG-GAP repeat protein
D2B33_RS12990	COG2755	lipolytic protein G-D-S-L family
D2B33_RS13000	COG3401	FG-GAP repeat protein
D2B33_RS13005	COG5578	integral membrane protein
D2B33_RS13015	COG2755	lipolytic protein G-D-S-L family
D2B33_RS13020	COG2207	Transcriptional regulator
D2B33_RS13025	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D2B33_RS13030	COG0395	ABC-type sugar transport system, permease component
D2B33_RS13035	COG1175	transmembrane transport
D2B33_RS13040	COG1653	transport
D2B33_RS13045	COG4753	response regulator
D2B33_RS13045	COG2207	Transcriptional regulator
D2B33_RS13050	COG2972	Histidine kinase
D2B33_RS13055	COG5578	integral membrane protein
D2B33_RS13060	COG0405	Gamma-glutamyltransferase
D2B33_RS13065	COG1392	Phosphate transport regulator
D2B33_RS13070	COG0306	phosphate transporter
D2B33_RS13085	COG2271	Major facilitator Superfamily
D2B33_RS13090	COG1063	alcohol dehydrogenase
D2B33_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS13100	COG1312	Catalyzes the dehydration of D-mannonate
D2B33_RS13105	COG1063	alcohol dehydrogenase
D2B33_RS13110	COG1802	Transcriptional regulator
D2B33_RS13120	COG3594	Acyltransferase
D2B33_RS13145	COG3778	Protein conserved in bacteria
D2B33_RS13150	COG3299	homolog of phage Mu protein gp47
D2B33_RS13155	COG3628	GPW Gp25 family protein
D2B33_RS13165	COG4193	domain, Protein
D2B33_RS13170	COG1652	LysM domain
D2B33_RS13175	COG5280	Phage tail tape measure protein TP901
D2B33_RS13175	COG3953	SLT domain
D2B33_RS13225	COG4653	Phage capsid family
D2B33_RS13230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D2B33_RS13235	COG5518	Phage portal protein
D2B33_RS13240	COG1783	phage Terminase large subunit
D2B33_RS13245	COG3728	DNA packaging
D2B33_RS13245	COG5484	DNA packaging
D2B33_RS13250	COG1595	DNA-templated transcription, initiation
D2B33_RS13265	COG1484	DNA-dependent DNA replication
D2B33_RS13270	COG1522	sequence-specific DNA binding
D2B33_RS13285	COG1396	sequence-specific DNA binding
D2B33_RS13290	COG2856	Zn peptidase
D2B33_RS13295	COG4195	phage-related replication protein
D2B33_RS13310	COG1309	transcriptional regulator
D2B33_RS13315	COG2814	Major facilitator Superfamily
D2B33_RS13320	COG1388	LysM domain
D2B33_RS13320	COG3584	3D domain protein
D2B33_RS13330	COG0346	lactoylglutathione lyase activity
D2B33_RS13335	COG0697	spore germination
D2B33_RS13340	COG0583	DNA-binding transcription factor activity
D2B33_RS13345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_RS13350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2B33_RS13355	COG0583	DNA-binding transcription factor activity
D2B33_RS13365	COG0110	maltose O-acetyltransferase activity
D2B33_RS13430	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS13440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_RS13455	COG5505	Protein of unknown function (DUF819)
D2B33_RS13460	COG0626	cystathionine gamma-synthase activity
D2B33_RS13465	COG0626	cystathionine gamma-synthase activity
D2B33_RS13485	COG2382	esterase
D2B33_RS13490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D2B33_RS13495	COG2153	protein acetylation
D2B33_RS13500	COG2246	polysaccharide biosynthetic process
D2B33_RS13505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2B33_RS13510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_RS13515	COG0586	Pfam SNARE associated Golgi protein
D2B33_RS13525	COG0210	DNA helicase
D2B33_RS13580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D2B33_RS13585	COG0351	phosphomethylpyrimidine kinase
D2B33_RS13590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2B33_RS13595	COG2022	thiamine diphosphate biosynthetic process
D2B33_RS13600	COG2104	thiamine diphosphate biosynthetic process
D2B33_RS13610	COG0352	thiamine-phosphate diphosphorylase activity
D2B33_RS13615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D2B33_RS13620	COG0569	domain protein
D2B33_RS13620	COG0475	glutathione-regulated potassium exporter activity
D2B33_RS13625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D2B33_RS13630	COG0564	pseudouridine synthase activity
D2B33_RS13635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2B33_RS13640	COG2357	RelA SpoT domain protein
D2B33_RS13650	COG4116	CYTH
D2B33_RS13655	COG0741	lytic transglycosylase activity
D2B33_RS13660	COG2346	COG2346, Truncated hemoglobins
D2B33_RS13665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D2B33_RS13670	COG1164	Oligoendopeptidase f
D2B33_RS13675	COG4469	Competence protein
D2B33_RS13680	COG3290	protein histidine kinase activity
D2B33_RS13685	COG4565	transcriptional regulatory protein
D2B33_RS13710	COG4862	establishment of competence for transformation
D2B33_RS13720	COG0861	Integral membrane protein TerC family
D2B33_RS13725	COG1393	Belongs to the ArsC family
D2B33_RS13730	COG0456	acetyltransferase
D2B33_RS13735	COG4608	Belongs to the ABC transporter superfamily
D2B33_RS13740	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS13745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS13750	COG0601	transmembrane transport
D2B33_RS13755	COG4166	transmembrane transport
D2B33_RS13760	COG0180	Tryptophanyl-tRNA synthetase
D2B33_RS13775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS13780	COG0601	transmembrane transport
D2B33_RS13790	COG4608	Belongs to the ABC transporter superfamily
D2B33_RS13795	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS13800	COG5504	Zn-dependent protease
D2B33_RS13805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2B33_RS13810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_RS13825	COG1744	ABC transporter substrate-binding protein PnrA-like
D2B33_RS13835	COG2267	carboxylic ester hydrolase activity
D2B33_RS13850	COG1968	undecaprenyl-diphosphatase activity
D2B33_RS13855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2B33_RS13860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2B33_RS13865	COG0505	Belongs to the CarA family
D2B33_RS13870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2B33_RS13875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D2B33_RS13880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D2B33_RS13885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D2B33_RS13890	COG2151	metal-sulfur cluster biosynthetic enzyme
D2B33_RS13895	COG1073	alpha beta
D2B33_RS13900	COG0561	phosphatase activity
D2B33_RS13910	COG0516	GMP reductase activity
D2B33_RS13920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS13925	COG1307	EDD domain protein, DegV family
D2B33_RS13940	COG2996	Protein conserved in bacteria
D2B33_RS13945	COG1666	GTP binding
D2B33_RS13950	COG0646	methionine synthase
D2B33_RS13950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D2B33_RS13955	COG1410	methionine synthase
D2B33_RS13955	COG0646	methionine synthase
D2B33_RS13960	COG2378	regulation of single-species biofilm formation
D2B33_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS13970	COG2153	protein acetylation
D2B33_RS13995	COG0076	glutamate decarboxylase activity
D2B33_RS14005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS14010	COG1279	arginine transmembrane transporter activity
D2B33_RS14015	COG0697	spore germination
D2B33_RS14030	COG0673	inositol 2-dehydrogenase activity
D2B33_RS14035	COG1609	Transcriptional regulator
D2B33_RS14045	COG1917	Cupin 2, conserved barrel domain protein
D2B33_RS14045	COG2207	Transcriptional regulator
D2B33_RS14050	COG0534	Mate efflux family protein
D2B33_RS14055	COG0347	Belongs to the P(II) protein family
D2B33_RS14060	COG0004	ammonium transporteR
D2B33_RS14065	COG0367	asparagine synthase
D2B33_RS14090	COG0179	Fumarylacetoacetate (FAA) hydrolase
D2B33_RS14100	COG5337	Spore coat protein CotH
D2B33_RS14145	COG0419	ATPase involved in DNA repair
D2B33_RS14150	COG0420	3'-5' exonuclease activity
D2B33_RS14155	COG1074	ATP-dependent DNA helicase activity
D2B33_RS14160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D2B33_RS14165	COG4149	molybdate abc transporter
D2B33_RS14170	COG0725	ABC transporter, periplasmic molybdate-binding protein
D2B33_RS14175	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D2B33_RS14185	COG0745	RESPONSE REGULATOR receiver
D2B33_RS14190	COG5002	protein histidine kinase activity
D2B33_RS14200	COG4533	DNA binding
D2B33_RS14205	COG0477	Major facilitator Superfamily
D2B33_RS14205	COG2814	Major facilitator Superfamily
D2B33_RS14210	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS14215	COG3546	catalase activity
D2B33_RS14230	COG3180	Ammonia monooxygenase
D2B33_RS14235	COG1486	melibiose metabolic process
D2B33_RS14240	COG0395	ABC-type sugar transport system, permease component
D2B33_RS14245	COG1175	transmembrane transport
D2B33_RS14250	COG1653	transport
D2B33_RS14255	COG1609	Transcriptional regulator
D2B33_RS14265	COG0457	Tetratricopeptide repeat
D2B33_RS14280	COG0549	Belongs to the carbamate kinase family
D2B33_RS14290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_RS14295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_RS14300	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D2B33_RS14305	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D2B33_RS14310	COG3257	ureidoglycine aminohydrolase activity
D2B33_RS14315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_RS14320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D2B33_RS14325	COG2508	Transcriptional regulator
D2B33_RS14335	COG1404	Belongs to the peptidase S8 family
D2B33_RS14340	COG0681	Belongs to the peptidase S26 family
D2B33_RS14345	COG0398	Pfam SNARE associated Golgi protein
D2B33_RS14355	COG4903	ComK protein
D2B33_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS14370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2B33_RS14370	COG0723	plastoquinol--plastocyanin reductase activity
D2B33_RS14375	COG0840	transmembrane signaling receptor activity
D2B33_RS14380	COG0406	alpha-ribazole phosphatase activity
D2B33_RS14385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS14390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS14395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D2B33_RS14400	COG0697	spore germination
D2B33_RS14410	COG0501	Belongs to the peptidase M48B family
D2B33_RS14425	COG1396	sequence-specific DNA binding
D2B33_RS14435	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS14440	COG0095	Lipoate-protein ligase
D2B33_RS14445	COG1234	tRNA 3'-trailer cleavage
D2B33_RS14455	COG1301	dicarboxylic acid transport
D2B33_RS14465	COG1363	Peptidase, m42
D2B33_RS14470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_RS14475	COG1511	domain protein
D2B33_RS14480	COG1309	transcriptional regulator
D2B33_RS14485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D2B33_RS14490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D2B33_RS14495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D2B33_RS14500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_RS14505	COG2329	Antibiotic biosynthesis monooxygenase
D2B33_RS14510	COG3069	C4-dicarboxylate transmembrane transporter activity
D2B33_RS14515	COG1473	amidohydrolase
D2B33_RS14525	COG4473	ABC transporter
D2B33_RS14530	COG1131	(ABC) transporter
D2B33_RS14535	COG0537	adenosine 5'-monophosphoramidase activity
D2B33_RS14540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D2B33_RS14555	COG4980	gas vesicle protein
D2B33_RS14560	COG1846	Transcriptional regulator
D2B33_RS14590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2B33_RS14600	COG3481	metal-dependent phosphohydrolase, HD sub domain
D2B33_RS14605	COG4717	serine-type aminopeptidase activity
D2B33_RS14610	COG0420	3'-5' exonuclease activity
D2B33_RS14615	COG1668	transmembrane transport
D2B33_RS14620	COG4152	abc transporter atp-binding protein
D2B33_RS14635	COG0457	Tetratricopeptide repeat
D2B33_RS14640	COG1024	Enoyl-CoA hydratase
D2B33_RS14650	COG0490	domain, Protein
D2B33_RS14655	COG0475	glutathione-regulated potassium exporter activity
D2B33_RS14660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2B33_RS14665	COG0561	phosphatase activity
D2B33_RS14675	COG3679	Belongs to the UPF0342 family
D2B33_RS14680	COG4399	Belongs to the UPF0754 family
D2B33_RS14685	COG0189	ligase activity
D2B33_RS14690	COG0189	ligase activity
D2B33_RS14700	COG2508	Transcriptional regulator
D2B33_RS14705	COG3842	ATPase activity
D2B33_RS14720	COG0702	epimerase
D2B33_RS14725	COG1132	(ABC) transporter
D2B33_RS14730	COG1132	(ABC) transporter
D2B33_RS14735	COG0589	response to stress
D2B33_RS14760	COG2017	converts alpha-aldose to the beta-anomer
D2B33_RS14765	COG1757	Na H antiporter
D2B33_RS14775	COG0726	polysaccharide deacetylase
D2B33_RS14785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D2B33_RS14790	COG0668	transmembrane transport
D2B33_RS14800	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_RS14805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2B33_RS14810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2B33_RS14830	COG1253	flavin adenine dinucleotide binding
D2B33_RS14835	COG0789	Transcriptional regulator
D2B33_RS14840	COG1253	flavin adenine dinucleotide binding
D2B33_RS14855	COG3152	Membrane
D2B33_RS14860	COG0204	Acyl-transferase
D2B33_RS14865	COG0667	Aldo Keto reductase
D2B33_RS14870	COG0662	Cupin 2, conserved barrel domain protein
D2B33_RS14875	COG1595	DNA-templated transcription, initiation
D2B33_RS14895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS14900	COG3708	Transcriptional regulator
D2B33_RS14900	COG2207	Transcriptional regulator
D2B33_RS14930	COG0733	neurotransmitter:sodium symporter activity
D2B33_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS14945	COG0372	Belongs to the citrate synthase family
D2B33_RS14950	COG0583	DNA-binding transcription factor activity
D2B33_RS14955	COG0791	NLP P60 protein
D2B33_RS14955	COG1388	LysM domain
D2B33_RS14960	COG2719	SpoVR family
D2B33_RS14965	COG1017	nitric oxide dioxygenase activity
D2B33_RS14965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D2B33_RS14970	COG1959	2 iron, 2 sulfur cluster binding
D2B33_RS14985	COG0431	NADPH-dependent FMN reductase
D2B33_RS14990	COG2197	response regulator
D2B33_RS14995	COG4585	Histidine kinase
D2B33_RS14995	COG2203	Gaf domain
D2B33_RS15010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2B33_RS15015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D2B33_RS15020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D2B33_RS15025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D2B33_RS15030	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D2B33_RS15035	COG0604	alcohol dehydrogenase
D2B33_RS15050	COG2116	formate transmembrane transporter activity
D2B33_RS15055	COG0488	(ABC) transporter
D2B33_RS15060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2B33_RS15060	COG3153	acetyltransferase
D2B33_RS15065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2B33_RS15070	COG0517	IMP dehydrogenase activity
D2B33_RS15080	COG0564	pseudouridine synthase activity
D2B33_RS15085	COG3764	Sortase (surface protein transpeptidase)
D2B33_RS15090	COG0737	Belongs to the 5'-nucleotidase family
D2B33_RS15090	COG1525	nuclease
D2B33_RS15090	COG4085	toxin activity
D2B33_RS15095	COG5002	protein histidine kinase activity
D2B33_RS15100	COG5577	PFAM Coat F domain
D2B33_RS15125	COG1823	symporter activity
D2B33_RS15130	COG1464	Belongs to the NlpA lipoprotein family
D2B33_RS15135	COG2011	ABC-type metal ion transport system permease component
D2B33_RS15140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2B33_RS15145	COG1278	Cold shock
D2B33_RS15150	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_RS15155	COG1131	(ABC) transporter
D2B33_RS15160	COG1131	(ABC) transporter
D2B33_RS15170	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS15175	COG2814	Major facilitator Superfamily
D2B33_RS15180	COG1566	PFAM secretion protein HlyD family protein
D2B33_RS15185	COG2718	Belongs to the UPF0229 family
D2B33_RS15190	COG2766	serine protein kinase
D2B33_RS15195	COG1664	Polymer-forming cytoskeletal
D2B33_RS15200	COG1664	Polymer-forming cytoskeletal
D2B33_RS15205	COG0789	Transcriptional regulator
D2B33_RS15210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D2B33_RS15220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D2B33_RS15225	COG3382	B3 4 domain protein
D2B33_RS15235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_RS15255	COG1131	(ABC) transporter
D2B33_RS15265	COG1476	TRANSCRIPTIONal
D2B33_RS15275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_RS15280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2B33_RS15285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2B33_RS15290	COG1116	anion transmembrane transporter activity
D2B33_RS15295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D2B33_RS15300	COG0710	3-dehydroquinate dehydratase activity
D2B33_RS15320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2B33_RS15325	COG0732	type I restriction modification DNA specificity domain
D2B33_RS15350	COG0457	Tetratricopeptide repeat
D2B33_RS15465	COG0735	belongs to the Fur family
D2B33_RS15470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D2B33_RS15475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D2B33_RS15480	COG4129	membrane
D2B33_RS15490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_RS15495	COG0601	transmembrane transport
D2B33_RS15500	COG0747	negative chemotaxis
D2B33_RS15505	COG4608	Belongs to the ABC transporter superfamily
D2B33_RS15510	COG0444	Belongs to the ABC transporter superfamily
D2B33_RS15515	COG1132	(ABC) transporter
D2B33_RS15520	COG3557	Belongs to the UPF0374 family
D2B33_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS15545	COG1194	a g-specific adenine glycosylase
D2B33_RS15550	COG1988	membrane-bound metal-dependent
D2B33_RS15555	COG4485	Bacterial membrane protein, YfhO
D2B33_RS15565	COG0463	Glycosyl transferase, family 2
D2B33_RS15590	COG2137	regulation of response to DNA damage stimulus
D2B33_RS15595	COG1090	epimerase
D2B33_RS15615	COG0778	Nitroreductase
D2B33_RS15620	COG0384	phenazine biosynthesis protein PhzF
D2B33_RS15625	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D2B33_RS15625	COG0392	lysyltransferase activity
D2B33_RS15635	COG1051	belongs to the nudix hydrolase family
D2B33_RS15640	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS15645	COG1653	transport
D2B33_RS15650	COG2207	Transcriptional regulator
D2B33_RS15650	COG1917	Cupin 2, conserved barrel domain protein
D2B33_RS15655	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS15665	COG2514	catechol 2,3-dioxygenase activity
D2B33_RS15670	COG2259	Doxx family
D2B33_RS15675	COG1733	regulation of RNA biosynthetic process
D2B33_RS15690	COG1263	PTS System
D2B33_RS15690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS15695	COG1737	Transcriptional regulator
D2B33_RS15700	COG1486	melibiose metabolic process
D2B33_RS15705	COG1742	UPF0060 membrane protein
D2B33_RS15710	COG3284	Transcriptional regulator
D2B33_RS15715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_RS15720	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_RS15725	COG0022	dehydrogenase e1 component
D2B33_RS15730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_RS15740	COG5609	conserved protein (DUF2294)
D2B33_RS15745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D2B33_RS15750	COG3002	Belongs to the UPF0753 family
D2B33_RS15755	COG0288	reversible hydration of carbon dioxide
D2B33_RS15760	COG3711	transcriptional antiterminator
D2B33_RS15765	COG1263	PTS System
D2B33_RS15765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS15775	COG0477	Major facilitator Superfamily
D2B33_RS15785	COG1819	glycosyl
D2B33_RS15810	COG4637	Psort location Cytoplasmic, score
D2B33_RS15815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2B33_RS15820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D2B33_RS15825	COG0598	Magnesium transport protein CorA
D2B33_RS15835	COG0371	Dehydrogenase
D2B33_RS15840	COG0726	polysaccharide deacetylase
D2B33_RS15850	COG0535	radical SAM domain protein
D2B33_RS15860	COG0387	Pfam Sodium calcium exchanger
D2B33_RS15870	COG0477	Major facilitator Superfamily
D2B33_RS15875	COG1295	ribonuclease BN
D2B33_RS15880	COG4980	gas vesicle protein
D2B33_RS15885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_RS15890	COG1115	amino acid carrier protein
D2B33_RS15895	COG4840	Belongs to the UPF0435 family
D2B33_RS15900	COG0693	protein deglycase activity
D2B33_RS15905	COG0737	Belongs to the 5'-nucleotidase family
D2B33_RS15910	COG0778	Nitroreductase
D2B33_RS15915	COG1733	regulation of RNA biosynthetic process
D2B33_RS15930	COG0673	inositol 2-dehydrogenase activity
D2B33_RS15940	COG0457	Tetratricopeptide repeat
D2B33_RS15940	COG0463	Glycosyl transferase, family 2
D2B33_RS15945	COG1215	transferase activity, transferring glycosyl groups
D2B33_RS15955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_RS15960	COG1045	serine acetyltransferase
D2B33_RS15965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_RS15990	COG2188	Transcriptional regulator
D2B33_RS15995	COG0366	Alpha amylase catalytic
D2B33_RS16000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS16000	COG1263	PTS System
D2B33_RS16005	COG1115	amino acid carrier protein
D2B33_RS16015	COG1368	sulfuric ester hydrolase activity
D2B33_RS16020	COG0024	Methionine aminopeptidase
D2B33_RS16030	COG2258	MOSC domain
D2B33_RS16035	COG1254	Belongs to the acylphosphatase family
D2B33_RS16040	COG0640	Transcriptional regulator
D2B33_RS16045	COG5658	integral membrane protein
D2B33_RS16050	COG3858	chitin binding
D2B33_RS16055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D2B33_RS16065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_RS16085	COG1136	(ABC) transporter
D2B33_RS16095	COG0471	metal ion transport
D2B33_RS16110	COG2130	NADP-dependent
D2B33_RS16115	COG0513	Belongs to the DEAD box helicase family
D2B33_RS16120	COG0488	(ABC) transporter
D2B33_RS16125	COG2814	Major facilitator Superfamily
D2B33_RS16130	COG0789	Transcriptional regulator
D2B33_RS16140	COG2124	cytochrome p450
D2B33_RS16145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D2B33_RS16150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D2B33_RS16155	COG0156	8-amino-7-oxononanoate synthase activity
D2B33_RS16160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2B33_RS16165	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
D2B33_RS16170	COG0523	cobalamin synthesis protein
D2B33_RS16185	COG1469	GTP cyclohydrolase I activity
D2B33_RS16190	COG0640	Transcriptional regulator
D2B33_RS16200	COG0583	DNA-binding transcription factor activity
D2B33_RS16205	COG0488	(ABC) transporter
D2B33_RS16210	COG0471	metal ion transport
D2B33_RS16215	COG1309	transcriptional regulator
D2B33_RS16220	COG0109	protoheme IX farnesyltransferase activity
D2B33_RS16225	COG0840	transmembrane signaling receptor activity
D2B33_RS16230	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS16260	COG0217	transcriptional regulatory protein
D2B33_RS16265	COG0697	spore germination
D2B33_RS16270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS16275	COG0697	spore germination
D2B33_RS16280	COG3586	endonuclease activity
D2B33_RS16285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D2B33_RS16285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_RS16300	COG0457	Tetratricopeptide repeat
D2B33_RS16305	COG3711	transcriptional antiterminator
D2B33_RS16340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2B33_RS16345	COG1597	lipid kinase activity
D2B33_RS16350	COG1957	nucleoside hydrolase
D2B33_RS16355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_RS16365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D2B33_RS16370	COG1309	transcriptional regulator
D2B33_RS16375	COG4124	Belongs to the glycosyl hydrolase 26 family
D2B33_RS16390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2B33_RS16395	COG0154	amidase activity
D2B33_RS16400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2B33_RS16405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS16410	COG1285	pathogenesis
D2B33_RS16415	COG0363	glucosamine-6-phosphate deaminase activity
D2B33_RS16420	COG3457	Alanine racemase
D2B33_RS16425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2B33_RS16430	COG0626	cystathionine gamma-synthase activity
D2B33_RS16435	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D2B33_RS16455	COG2188	Transcriptional regulator
D2B33_RS16460	COG4851	CamS sex pheromone cAM373 precursor
D2B33_RS16465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D2B33_RS16470	COG0210	DNA helicase
D2B33_RS16475	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D2B33_RS16480	COG4496	protein, YerC YecD
D2B33_RS16485	COG1470	cell adhesion involved in biofilm formation
D2B33_RS16490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D2B33_RS16515	COG2124	cytochrome p450
D2B33_RS16525	COG0151	Belongs to the GarS family
D2B33_RS16530	COG0138	bifunctional purine biosynthesis protein purh
D2B33_RS16535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D2B33_RS16540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D2B33_RS16545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D2B33_RS16550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2B33_RS16555	COG0047	phosphoribosylformylglycinamidine synthase activity
D2B33_RS16560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2B33_RS16565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D2B33_RS16570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D2B33_RS16575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D2B33_RS16580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D2B33_RS16590	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D2B33_RS16605	COG2252	PERMEase
D2B33_RS16615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D2B33_RS16615	COG0519	Catalyzes the synthesis of GMP from XMP
D2B33_RS16620	COG1305	Transglutaminase-like
D2B33_RS16625	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D2B33_RS16630	COG0714	Associated with various cellular activities
D2B33_RS16635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2B33_RS16655	COG2132	Multicopper oxidase
D2B33_RS16665	COG0702	epimerase
D2B33_RS16695	COG0823	Involved in the tonB-independent uptake of proteins
D2B33_RS16700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D2B33_RS16715	COG1846	Transcriptional regulator
D2B33_RS16720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D2B33_RS16725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2B33_RS16730	COG0366	Alpha amylase catalytic
D2B33_RS16735	COG1554	hydrolase, family 65, central catalytic
D2B33_RS16740	COG5521	maltodextrose utilization protein MalA
D2B33_RS16745	COG3833	ABC-type maltose transport systems, permease component
D2B33_RS16750	COG1175	transmembrane transport
D2B33_RS16755	COG2182	Extracellular solute-binding protein
D2B33_RS16760	COG0366	Alpha amylase catalytic
D2B33_RS16765	COG1609	Transcriptional regulator
D2B33_RS16780	COG0726	polysaccharide deacetylase
D2B33_RS16800	COG0772	Belongs to the SEDS family
D2B33_RS16805	COG0772	Belongs to the SEDS family
D2B33_RS16810	COG3339	Conserved Protein
D2B33_RS16815	COG1280	lysine exporter protein (LysE YggA)
D2B33_RS16820	COG1378	Sugar-specific transcriptional regulator TrmB
D2B33_RS16830	COG4260	virion core protein, lumpy skin disease virus
D2B33_RS16835	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D2B33_RS16840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2B33_RS16845	COG1842	Phage shock protein A
D2B33_RS16850	COG2814	Major facilitator Superfamily
D2B33_RS16855	COG2272	Belongs to the type-B carboxylesterase lipase family
D2B33_RS16860	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D2B33_RS16875	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_RS16875	COG3848	Pyruvate phosphate dikinase
D2B33_RS16880	COG1309	transcriptional regulator
D2B33_RS16890	COG2135	peptidase activity
D2B33_RS16910	COG2720	vancomycin resistance protein
D2B33_RS16920	COG0459	protein refolding
D2B33_RS16925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D2B33_RS16930	COG1266	CAAX protease self-immunity
D2B33_RS16940	COG0805	protein transport
D2B33_RS16945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2B33_RS16950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D2B33_RS16955	COG0315	cyclic pyranopterin monophosphate synthase activity
D2B33_RS16960	COG0488	(ABC) transporter
D2B33_RS16965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D2B33_RS16970	COG0456	acetyltransferase
D2B33_RS16975	COG1214	PFAM Peptidase M22, glycoprotease
D2B33_RS16980	COG0802	atpase or kinase
D2B33_RS16985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D2B33_RS17025	COG2814	Major facilitator Superfamily
D2B33_RS17030	COG3764	Sortase (surface protein transpeptidase)
D2B33_RS17040	COG3279	Response regulator of the LytR AlgR family
D2B33_RS17045	COG2972	Histidine kinase
D2B33_RS17045	COG0745	RESPONSE REGULATOR receiver
D2B33_RS17050	COG1979	alcohol dehydrogenase
D2B33_RS17055	COG2814	Major facilitator Superfamily
D2B33_RS17060	COG0494	nUDIX hydrolase
D2B33_RS17065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D2B33_RS17065	COG2755	lipolytic protein G-D-S-L family
D2B33_RS17075	COG1595	DNA-templated transcription, initiation
D2B33_RS17080	COG5566	PFAM Mor transcription activator
D2B33_RS17085	COG0596	Alpha beta hydrolase
D2B33_RS17100	COG1113	amino acid transport
D2B33_RS17105	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D2B33_RS17120	COG1733	regulation of RNA biosynthetic process
D2B33_RS17125	COG3545	Serine hydrolase
D2B33_RS17150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS17155	COG1733	regulation of RNA biosynthetic process
D2B33_RS17165	COG2808	Putative FMN-binding domain
D2B33_RS17170	COG0456	acetyltransferase
D2B33_RS17175	COG1846	Transcriptional regulator
D2B33_RS17180	COG2364	Membrane
D2B33_RS17210	COG1278	Cold shock
D2B33_RS17215	COG3239	Fatty acid desaturase
D2B33_RS17220	COG1476	TRANSCRIPTIONal
D2B33_RS17230	COG0726	polysaccharide deacetylase
D2B33_RS17270	COG3091	SprT-like family
D2B33_RS17280	COG1033	growth of symbiont in host cell
D2B33_RS17280	COG2409	Drug exporters of the RND superfamily
D2B33_RS17290	COG1309	transcriptional regulator
D2B33_RS17295	COG2183	response to ionizing radiation
D2B33_RS17300	COG2208	phosphoserine phosphatase activity
D2B33_RS17305	COG1191	sigma factor activity
D2B33_RS17320	COG2208	phosphoserine phosphatase activity
D2B33_RS17325	COG2172	sigma factor antagonist activity
D2B33_RS17330	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_RS17335	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_RS17340	COG2337	Toxic component of a toxin-antitoxin (TA) module
D2B33_RS17345	COG0864	Transcriptional regulator
D2B33_RS17350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2B33_RS17355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D2B33_RS17360	COG0705	Rhomboid family
D2B33_RS17365	COG3428	Bacterial PH domain
D2B33_RS17370	COG3402	PFAM membrane-flanked domain
D2B33_RS17375	COG0513	Belongs to the DEAD box helicase family
D2B33_RS17385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D2B33_RS17390	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2B33_RS17395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_RS17410	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS17420	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_RS17425	COG1131	(ABC) transporter
D2B33_RS17430	COG1301	dicarboxylic acid transport
D2B33_RS17435	COG0628	permease
D2B33_RS17445	COG0662	Cupin 2, conserved barrel domain protein
D2B33_RS17455	COG2217	Heavy metal translocating P-type atpase
D2B33_RS17460	COG4876	unkown
D2B33_RS17465	COG1819	glycosyl
D2B33_RS17470	COG1027	Aspartate ammonia-lyase
D2B33_RS17475	COG2261	transglycosylase associated protein
D2B33_RS17480	COG1914	H( )-stimulated, divalent metal cation uptake system
D2B33_RS17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_RS17495	COG3397	chitin binding
D2B33_RS17500	COG0028	Belongs to the TPP enzyme family
D2B33_RS17505	COG1605	Chorismate mutase
D2B33_RS17510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_RS17510	COG0512	Glutamine amidotransferase of anthranilate synthase
D2B33_RS17515	COG0287	Prephenate dehydrogenase
D2B33_RS17520	COG0551	DNA topoisomerase type I activity
D2B33_RS17520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2B33_RS17525	COG1522	sequence-specific DNA binding
D2B33_RS17535	COG2814	Major facilitator Superfamily
D2B33_RS17550	COG3871	stress protein (general stress protein 26)
D2B33_RS17560	COG1917	Cupin 2, conserved barrel domain protein
D2B33_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS17570	COG3711	transcriptional antiterminator
D2B33_RS17575	COG0246	Mannitol dehydrogenase
D2B33_RS17580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS17585	COG2213	PTS system mannitol-specific
D2B33_RS17595	COG2755	lipolytic protein G-D-S-L family
D2B33_RS17600	COG1414	Transcriptional regulator
D2B33_RS17605	COG1984	allophanate hydrolase subunit 2
D2B33_RS17610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D2B33_RS17615	COG4336	lyase activity
D2B33_RS17620	COG1914	H( )-stimulated, divalent metal cation uptake system
D2B33_RS17625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D2B33_RS17630	COG0561	phosphatase activity
D2B33_RS17635	COG3958	Transketolase
D2B33_RS17640	COG3959	Transketolase, thiamine diphosphate binding domain
D2B33_RS17655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS17665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D2B33_RS17670	COG0471	metal ion transport
D2B33_RS17675	COG1802	Transcriptional regulator
D2B33_RS17680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2B33_RS17680	COG1587	Uroporphyrinogen-III synthase
D2B33_RS17685	COG2146	nitrite reductase [NAD(P)H] activity
D2B33_RS17690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_RS17695	COG0243	molybdopterin cofactor binding
D2B33_RS17700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_RS17705	COG1349	DNA-binding transcription factor activity
D2B33_RS17710	COG2372	response to copper ion
D2B33_RS17710	COG1276	copper resistance
D2B33_RS17715	COG4549	nuclear export factor GLE1
D2B33_RS17725	COG0697	spore germination
D2B33_RS17730	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS17735	COG0531	amino acid
D2B33_RS17740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D2B33_RS17745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS17750	COG0640	Transcriptional regulator
D2B33_RS17755	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2B33_RS17760	COG0778	Nitroreductase
D2B33_RS17770	COG1309	transcriptional regulator
D2B33_RS17775	COG2814	Major facilitator Superfamily
D2B33_RS17780	COG4607	ABC-type enterochelin transport system periplasmic component
D2B33_RS17785	COG4604	ABC transporter, ATP-binding protein
D2B33_RS17790	COG4605	iron ion homeostasis
D2B33_RS17795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS17800	COG0527	aspartate kinase activity
D2B33_RS17805	COG0840	transmembrane signaling receptor activity
D2B33_RS17810	COG3850	Histidine kinase
D2B33_RS17810	COG5002	protein histidine kinase activity
D2B33_RS17815	COG0745	RESPONSE REGULATOR receiver
D2B33_RS17820	COG0577	efflux transmembrane transporter activity
D2B33_RS17825	COG1136	(ABC) transporter
D2B33_RS17830	COG0789	Transcriptional regulator
D2B33_RS17835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D2B33_RS17845	COG0697	spore germination
D2B33_RS17855	COG5434	Belongs to the glycosyl hydrolase 28 family
D2B33_RS17860	COG3104	oligopeptide transport
D2B33_RS17870	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D2B33_RS17875	COG1874	Beta-galactosidase
D2B33_RS17880	COG0456	acetyltransferase
D2B33_RS17880	COG1846	Transcriptional regulator
D2B33_RS17885	COG2271	Major facilitator Superfamily
D2B33_RS17890	COG4214	carbohydrate transport
D2B33_RS17900	COG4213	ABC transporter substrate-binding protein
D2B33_RS17905	COG4753	response regulator
D2B33_RS17905	COG2207	Transcriptional regulator
D2B33_RS17910	COG2972	Histidine kinase
D2B33_RS17990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D2B33_RS17995	COG0163	prenyltransferase activity
D2B33_RS18000	COG0583	DNA-binding transcription factor activity
D2B33_RS18005	COG0010	Belongs to the arginase family
D2B33_RS18010	COG0833	amino acid
D2B33_RS18015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2B33_RS18020	COG3829	transcription factor binding
D2B33_RS18025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_RS18030	COG0765	amino acid transport
D2B33_RS18035	COG1126	abc transporter atp-binding protein
D2B33_RS18065	COG2364	Membrane
D2B33_RS18070	COG3708	Transcriptional regulator
D2B33_RS18070	COG2207	Transcriptional regulator
D2B33_RS18075	COG2819	hydrolase of the alpha beta superfamily
D2B33_RS18085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS18090	COG0697	spore germination
D2B33_RS18095	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D2B33_RS18100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS18105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS18110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS18115	COG1177	transmembrane transport
D2B33_RS18145	COG5444	nuclease activity
D2B33_RS18155	COG3209	COG3209 Rhs family protein
D2B33_RS18165	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS18170	COG1116	anion transmembrane transporter activity
D2B33_RS18175	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS18180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_RS18185	COG0765	amino acid transport
D2B33_RS18210	COG3458	cephalosporin-C deacetylase activity
D2B33_RS18215	COG0701	Predicted permease
D2B33_RS18220	COG3689	TIGRFAM TIGR03943 family protein
D2B33_RS18225	COG2508	Transcriptional regulator
D2B33_RS18230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS18235	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS18240	COG0506	proline dehydrogenase activity
D2B33_RS18245	COG3541	Predicted nucleotidyltransferase
D2B33_RS18250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D2B33_RS18255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D2B33_RS18260	COG1113	amino acid transport
D2B33_RS18265	COG1280	lysine exporter protein (LysE YggA)
D2B33_RS18270	COG1620	l-lactate permease
D2B33_RS18275	COG0039	L-malate dehydrogenase activity
D2B33_RS18280	COG2223	nitrite transmembrane transporter activity
D2B33_RS18290	COG0785	Cytochrome C biogenesis protein
D2B33_RS18295	COG3853	Toxic anion resistance protein (TelA)
D2B33_RS18315	COG0861	Integral membrane protein TerC family
D2B33_RS18320	COG2310	stress, protein
D2B33_RS18325	COG2310	stress, protein
D2B33_RS18330	COG2310	stress, protein
D2B33_RS18345	COG1309	transcriptional regulator
D2B33_RS18350	COG1131	(ABC) transporter
D2B33_RS18360	COG0791	NLP P60 protein
D2B33_RS18360	COG3883	PFAM NLP P60 protein
D2B33_RS18365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_RS18370	COG3773	Cell wall hydrolase
D2B33_RS18380	COG1595	DNA-templated transcription, initiation
D2B33_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS18395	COG3591	Belongs to the peptidase S1B family
D2B33_RS18410	COG3394	polysaccharide catabolic process
D2B33_RS18415	COG2188	Transcriptional regulator
D2B33_RS18420	COG1486	melibiose metabolic process
D2B33_RS18425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS18430	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_RS18435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS18440	COG0277	FAD linked oxidase domain protein
D2B33_RS18445	COG0247	lactate metabolic process
D2B33_RS18455	COG2261	transglycosylase associated protein
D2B33_RS18460	COG1164	Oligoendopeptidase f
D2B33_RS18470	COG0456	acetyltransferase
D2B33_RS18475	COG0252	asparaginase activity
D2B33_RS18485	COG1288	antiporter activity
D2B33_RS18500	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_RS18505	COG1942	4-Oxalocrotonate Tautomerase
D2B33_RS18510	COG0583	DNA-binding transcription factor activity
D2B33_RS18535	COG1131	(ABC) transporter
D2B33_RS18540	COG3012	SEC-C Motif Domain Protein
D2B33_RS18540	COG1405	negative regulation of cell septum assembly
D2B33_RS18545	COG0697	spore germination
D2B33_RS18570	COG0789	Transcriptional regulator
D2B33_RS18590	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_RS18595	COG1846	Transcriptional regulator
D2B33_RS18600	COG3173	Aminoglycoside phosphotransferase
D2B33_RS18625	COG1131	(ABC) transporter
D2B33_RS18630	COG2205	protein histidine kinase activity
D2B33_RS18635	COG0745	RESPONSE REGULATOR receiver
D2B33_RS18655	COG2721	sulfolactate sulfo-lyase activity
D2B33_RS18660	COG2186	Transcriptional regulator
D2B33_RS18665	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_RS18670	COG2271	Major facilitator Superfamily
D2B33_RS18675	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS18680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_RS18685	COG0805	protein transport
D2B33_RS18690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2B33_RS18695	COG3540	Alkaline phosphatase
D2B33_RS18720	COG0784	Response regulator, receiver
D2B33_RS18725	COG4191	Histidine kinase
D2B33_RS18730	COG2066	Belongs to the glutaminase family
D2B33_RS18735	COG1115	amino acid carrier protein
D2B33_RS18740	COG2205	protein histidine kinase activity
D2B33_RS18750	COG4451	ribulose bisphosphate carboxylase, small
D2B33_RS18750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D2B33_RS18755	COG2323	membrane
D2B33_RS18760	COG0789	Transcriptional regulator
D2B33_RS18765	COG1263	PTS System
D2B33_RS18765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS18775	COG2040	homocysteine
D2B33_RS18780	COG0833	amino acid
D2B33_RS18790	COG4257	antibiotic catabolic process
D2B33_RS18805	COG0371	Dehydrogenase
D2B33_RS18820	COG2197	response regulator
D2B33_RS18830	COG1917	Cupin 2, conserved barrel domain protein
D2B33_RS18830	COG2207	Transcriptional regulator
D2B33_RS18835	COG0697	spore germination
D2B33_RS18860	COG4682	membrane
D2B33_RS18865	COG1283	sodium-dependent phosphate transmembrane transporter activity
D2B33_RS18885	COG0730	response to heat
D2B33_RS18890	COG1802	Transcriptional regulator
D2B33_RS18895	COG0778	Nitroreductase
D2B33_RS18900	COG0076	glutamate decarboxylase activity
D2B33_RS18905	COG2226	methyltransferase
D2B33_RS18930	COG0789	Transcriptional regulator
D2B33_RS18935	COG0697	spore germination
D2B33_RS18940	COG1331	Highly conserved protein containing a thioredoxin domain
D2B33_RS18960	COG2211	Major facilitator Superfamily
D2B33_RS18980	COG1011	Hydrolase
D2B33_RS19000	COG2312	Erythromycin esterase
D2B33_RS19005	COG1132	(ABC) transporter
D2B33_RS19015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D2B33_RS19020	COG1132	(ABC) transporter
D2B33_RS19035	COG1309	transcriptional regulator
D2B33_RS19040	COG2814	Major facilitator Superfamily
D2B33_RS19045	COG0640	Transcriptional regulator
D2B33_RS19050	COG1725	Transcriptional regulator
D2B33_RS19070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D2B33_RS19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2B33_RS19080	COG4856	YbbR-like protein
D2B33_RS19085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D2B33_RS19090	COG5662	AntiSigma factor
D2B33_RS19095	COG1595	DNA-templated transcription, initiation
D2B33_RS19130	COG1683	Conserved Protein
D2B33_RS19135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D2B33_RS19140	COG1737	Transcriptional regulator
D2B33_RS19145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS19145	COG1263	PTS System
D2B33_RS19150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_RS19155	COG1472	Belongs to the glycosyl hydrolase 3 family
D2B33_RS19160	COG3876	Protein conserved in bacteria
D2B33_RS19175	COG0385	Bile acid
D2B33_RS19185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_RS19215	COG0726	polysaccharide deacetylase
D2B33_RS19220	COG2194	sulfuric ester hydrolase activity
D2B33_RS19230	COG0489	protein tyrosine kinase activity
D2B33_RS19235	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_RS19260	COG3290	protein histidine kinase activity
D2B33_RS19285	COG2274	protein secretion by the type I secretion system
D2B33_RS19315	COG1131	(ABC) transporter
D2B33_RS19335	COG2318	DinB family
D2B33_RS19360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D2B33_RS19365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D2B33_RS19370	COG0101	tRNA pseudouridine synthase activity
D2B33_RS19375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2B33_RS19380	COG1122	ATPase activity
D2B33_RS19385	COG1122	ATPase activity
D2B33_RS19390	COG0203	ribosomal protein L17
D2B33_RS19395	COG0202	RNA polymerase activity
D2B33_RS19400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D2B33_RS19405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D2B33_RS19410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D2B33_RS19415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D2B33_RS19420	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D2B33_RS19425	COG0024	Methionine aminopeptidase
D2B33_RS19430	COG0563	adenylate kinase activity
D2B33_RS19435	COG0201	protein transport
D2B33_RS19440	COG0200	Binds to the 23S rRNA
D2B33_RS19445	COG1841	ribosomal large subunit assembly
D2B33_RS19450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D2B33_RS19455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D2B33_RS19460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D2B33_RS19465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D2B33_RS19470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_RS19475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D2B33_RS19480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D2B33_RS19485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D2B33_RS19490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D2B33_RS19495	COG0255	Belongs to the universal ribosomal protein uL29 family
D2B33_RS19500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D2B33_RS19505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D2B33_RS19510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D2B33_RS19515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D2B33_RS19525	COG0089	rRNA binding
D2B33_RS19530	COG0088	Forms part of the polypeptide exit tunnel
D2B33_RS19535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D2B33_RS19545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D2B33_RS19550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D2B33_RS19555	COG0049	tRNA binding
D2B33_RS19560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D2B33_RS19565	COG1358	cellular component organization or biogenesis
D2B33_RS19570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D2B33_RS19575	COG0085	RNA polymerase activity
D2B33_RS19580	COG2813	Specifically methylates the guanine in position
D2B33_RS19585	COG0222	ribosome binding
D2B33_RS19590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D2B33_RS19595	COG0081	regulation of translation
D2B33_RS19600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D2B33_RS19605	COG0250	Participates in transcription elongation, termination and antitermination
D2B33_RS19625	COG3688	RNA-binding protein containing a PIN domain
D2B33_RS19630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2B33_RS19635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D2B33_RS19640	COG0215	cysteine-tRNA ligase activity
D2B33_RS19645	COG1045	serine acetyltransferase
D2B33_RS19650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D2B33_RS19655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D2B33_RS19660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D2B33_RS19665	COG4956	integral membrane protein (PIN domain superfamily)
D2B33_RS19670	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D2B33_RS19675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D2B33_RS19680	COG0542	response to heat
D2B33_RS19685	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D2B33_RS19690	COG3880	PFAM UvrB UvrC protein
D2B33_RS19695	COG4463	regulation of RNA biosynthetic process
D2B33_RS19775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D2B33_RS19780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D2B33_RS19785	COG1396	sequence-specific DNA binding
D2B33_RS19790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D2B33_RS19795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D2B33_RS19800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D2B33_RS19805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_RS19810	COG0512	Glutamine amidotransferase of anthranilate synthase
D2B33_RS19815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_RS19820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_RS19825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2B33_RS19830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D2B33_RS19835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D2B33_RS19840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D2B33_RS19845	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D2B33_RS19850	COG0037	tRNA processing
D2B33_RS19855	COG0515	serine threonine protein kinase
D2B33_RS19860	COG2304	oxidoreductase activity
D2B33_RS19865	COG2208	phosphoserine phosphatase activity
D2B33_RS19880	COG1098	S1 RNA binding domain
D2B33_RS19885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D2B33_RS19900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D2B33_RS19905	COG3956	TIGRFAM MazG family protein
D2B33_RS19910	COG2244	polysaccharide biosynthetic process
D2B33_RS19915	COG2002	toxin-antitoxin pair type II binding
D2B33_RS19920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D2B33_RS19930	COG0193	aminoacyl-tRNA hydrolase activity
D2B33_RS19935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D2B33_RS19940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D2B33_RS19945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D2B33_RS19950	COG2088	sporulation resulting in formation of a cellular spore
D2B33_RS19955	COG0251	oxidation-reduction process
D2B33_RS19960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_RS19965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D2B33_RS19975	COG4466	Protein conserved in bacteria
D2B33_RS19985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D2B33_RS19990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2B33_RS19995	COG3584	3D domain protein
D2B33_RS19995	COG3583	domain protein
D2B33_RS20000	COG0084	hydrolase, TatD family'
D2B33_RS20005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_RS20005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_RS20010	COG2002	toxin-antitoxin pair type II binding
D2B33_RS20015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D2B33_RS20020	COG2827	Endonuclease containing a URI domain
D2B33_RS20025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D2B33_RS20030	COG4467	Involved in initiation control of chromosome replication
D2B33_RS20035	COG1774	PSP1 C-terminal conserved region
D2B33_RS20040	COG0470	DNA polymerase III
D2B33_RS20045	COG1728	Protein conserved in bacteria
D2B33_RS20050	COG3870	Protein conserved in bacteria
D2B33_RS20055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D2B33_RS20060	COG1982	Orn Lys Arg decarboxylase major
D2B33_RS20065	COG3853	Toxic anion resistance protein (TelA)
D2B33_RS20070	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D2B33_RS20115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D2B33_RS20120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D2B33_RS20125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D2B33_RS20135	COG0590	tRNA wobble adenosine to inosine editing
D2B33_RS20140	COG1335	isochorismatase
D2B33_RS20145	COG3858	chitin binding
D2B33_RS20145	COG1388	LysM domain
D2B33_RS20150	COG1428	Deoxynucleoside kinase
D2B33_RS20155	COG1428	Deoxynucleoside kinase
D2B33_RS20170	COG3835	regulator
D2B33_RS20175	COG2610	gluconate transmembrane transporter activity
D2B33_RS20180	COG1929	Belongs to the glycerate kinase type-1 family
D2B33_RS20185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D2B33_RS20190	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D2B33_RS20195	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D2B33_RS20200	COG1686	Belongs to the peptidase S11 family
D2B33_RS20205	COG0517	IMP dehydrogenase activity
D2B33_RS20205	COG0516	GMP reductase activity
D2B33_RS20240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2B33_RS20245	COG0187	DNA topoisomerase II activity
D2B33_RS20255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D2B33_RS20260	COG2501	S4 domain
D2B33_RS20265	COG0592	DNA-directed DNA polymerase activity
D2B33_RS20270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D2B33_RS20280	COG0594	ribonuclease P activity
D2B33_RS20285	COG0706	membrane insertase activity
D2B33_RS20290	COG1847	R3H domain protein
D2B33_RS20295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D2B33_RS20300	COG0445	tRNA wobble uridine modification
D2B33_RS20305	COG0357	Ribosomal RNA small subunit methyltransferase G
D2B33_RS20310	COG1475	DNA binding
D2B33_RS20315	COG1595	DNA-templated transcription, initiation
D2B33_RS20320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D2B33_RS20325	COG1192	Involved in chromosome partitioning
D2B33_RS20330	COG1475	DNA binding
D2B33_RS20340	COG3949	Membrane
D2B33_RS20345	COG4481	Protein conserved in bacteria
D2B33_RS20350	COG0012	GTP binding
D2B33_RS20355	COG0360	Binds together with S18 to 16S ribosomal RNA
D2B33_RS20360	COG0629	single-stranded DNA binding
D2B33_RS20365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D2B33_RS20370	COG2271	Major facilitator Superfamily
D2B33_RS20375	COG0659	secondary active sulfate transmembrane transporter activity
D2B33_RS20380	COG0589	response to stress
D2B33_RS20385	COG5577	PFAM Coat F domain
D2B33_RS20390	COG4241	membrane
D2B33_RS20395	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D2B33_RS20400	COG0359	binds to the 23S rRNA
D2B33_RS20405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS20405	COG1263	PTS System
D2B33_RS20410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D2B33_RS20415	COG2188	Transcriptional regulator
D2B33_RS20420	COG0363	glucosamine-6-phosphate deaminase activity
D2B33_RS20425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D2B33_RS20430	COG2807	transmembrane transport
D2B33_RS20435	COG3093	addiction module antidote protein HigA
D2B33_RS20450	COG0305	Participates in initiation and elongation during chromosome replication
D2B33_RS20460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D2B33_RS20490	COG0745	RESPONSE REGULATOR receiver
D2B33_RS20495	COG5002	protein histidine kinase activity
D2B33_RS20500	COG4863	YycH protein
D2B33_RS20505	COG4853	Protein conserved in bacteria
D2B33_RS20510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D2B33_RS20515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_RS20530	COG0456	acetyltransferase
D2B33_RS20545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D2B33_RS20555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2B33_RS20560	COG2197	response regulator
D2B33_RS20565	COG4585	Histidine kinase
D2B33_RS20570	COG0842	Transport permease protein
D2B33_RS20575	COG1131	(ABC) transporter
D2B33_RS20590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS20595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_RS20600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS20620	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D2B33_RS20640	COG1113	amino acid transport
D2B33_RS20645	COG3634	alkyl hydroperoxide reductase activity
D2B33_RS20650	COG0450	alkyl hydroperoxide reductase
D2B33_RS20655	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS20655	COG1454	alcohol dehydrogenase
D2B33_RS20685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_RS20695	COG1940	carbohydrate kinase activity
D2B33_RS20700	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D2B33_RS20705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_RS20710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D2B33_RS20715	COG1609	Transcriptional regulator
D2B33_RS20720	COG2182	Extracellular solute-binding protein
D2B33_RS20725	COG1175	transmembrane transport
D2B33_RS20730	COG3833	ABC-type maltose transport systems, permease component
D2B33_RS20735	COG1874	Beta-galactosidase
D2B33_RS20740	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D2B33_RS20745	COG0686	Belongs to the AlaDH PNT family
D2B33_RS20750	COG1115	amino acid carrier protein
D2B33_RS20755	COG0840	transmembrane signaling receptor activity
D2B33_RS20755	COG5278	phosphoserine phosphatase activity
D2B33_RS20765	COG0745	RESPONSE REGULATOR receiver
D2B33_RS20770	COG2205	protein histidine kinase activity
D2B33_RS20775	COG1136	(ABC) transporter
D2B33_RS20780	COG0577	efflux transmembrane transporter activity
D2B33_RS20785	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D2B33_RS20815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_RS20835	COG0561	phosphatase activity
D2B33_RS20840	COG0488	(ABC) transporter
D2B33_RS20845	COG0326	Molecular chaperone. Has ATPase activity
D2B33_RS20850	COG2271	Major facilitator Superfamily
D2B33_RS20855	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_RS20860	COG0667	Aldo Keto reductase
D2B33_RS20865	COG1349	DNA-binding transcription factor activity
D2B33_RS20870	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_RS20875	COG3718	enzyme involved in inositol metabolism
D2B33_RS20880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_RS20885	COG3962	Belongs to the TPP enzyme family
D2B33_RS20890	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_RS20895	COG2814	Major facilitator Superfamily
D2B33_RS20900	COG0673	inositol 2-dehydrogenase activity
D2B33_RS20905	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_RS20910	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_RS20915	COG0191	fructose-bisphosphate aldolase activity
D2B33_RS20925	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2B33_RS20940	COG3977	Valine--pyruvate aminotransferase
D2B33_RS20950	COG1215	transferase activity, transferring glycosyl groups
D2B33_RS20955	COG5298	Protein conserved in bacteria
D2B33_RS20960	COG3706	GGDEF domain
D2B33_RS20965	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D2B33_RS20970	COG2390	Transcriptional regulator
D2B33_RS20975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D2B33_RS20980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2B33_RS20985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D2B33_RS21025	COG0513	Belongs to the DEAD box helicase family
D2B33_RS21030	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_RS21035	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D2B33_RS21045	COG2190	(PTS) system
D2B33_RS21045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS21045	COG1263	PTS System
D2B33_RS21050	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS21055	COG0745	RESPONSE REGULATOR receiver
D2B33_RS21060	COG2205	protein histidine kinase activity
D2B33_RS21065	COG1136	(ABC) transporter
D2B33_RS21070	COG0577	efflux transmembrane transporter activity
D2B33_RS21075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D2B33_RS21085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D2B33_RS21090	COG2224	Isocitrate lyase
D2B33_RS21095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D2B33_RS21100	COG4721	ABC-type cobalt transport system, permease component
D2B33_RS21105	COG1122	ATPase activity
D2B33_RS21110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2B33_RS21115	COG3711	transcriptional antiterminator
D2B33_RS21120	COG1263	PTS System
D2B33_RS21120	COG2190	(PTS) system
D2B33_RS21120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS21125	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS21135	COG0693	protein deglycase activity
D2B33_RS21135	COG0753	catalase activity
D2B33_RS21160	COG2233	PERMEase
D2B33_RS21165	COG2363	Small membrane protein
D2B33_RS21180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D2B33_RS21185	COG1216	Glycosyl transferase, family 2
D2B33_RS21190	COG0351	phosphomethylpyrimidine kinase
D2B33_RS21200	COG1621	beta-fructofuranosidase activity
D2B33_RS21205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_RS21205	COG1263	PTS System
D2B33_RS21210	COG3711	transcriptional antiterminator
D2B33_RS21220	COG1404	Belongs to the peptidase S8 family
D2B33_RS21230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_RS21235	COG0778	Nitroreductase
D2B33_RS21240	COG1473	amidohydrolase
D2B33_RS21245	COG0772	Belongs to the SEDS family
D2B33_RS21250	COG0772	Belongs to the SEDS family
D2B33_RS21255	COG3314	Sporulation integral membrane protein YlbJ
D2B33_RS21270	COG0456	acetyltransferase
D2B33_RS21305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D2B33_RS21315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2B33_RS21320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2B33_RS21325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_RS21335	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_RS21340	COG3162	membrane
D2B33_RS21345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS21350	COG1070	Carbohydrate kinase
D2B33_RS21355	COG2115	Belongs to the xylose isomerase family
D2B33_RS21360	COG1940	carbohydrate kinase activity
D2B33_RS21365	COG0352	thiamine-phosphate diphosphorylase activity
D2B33_RS21370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D2B33_RS21375	COG0583	DNA-binding transcription factor activity
D2B33_RS21390	COG1380	Effector of murein hydrolase LrgA
D2B33_RS21395	COG1346	cytolysis
D2B33_RS21400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_RS21405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D2B33_RS21410	COG0346	lactoylglutathione lyase activity
D2B33_RS21415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_RS21420	COG1442	glycosyl transferase family 8
D2B33_RS21435	COG4585	Histidine kinase
D2B33_RS21440	COG2197	response regulator
D2B33_RS21445	COG2409	Drug exporters of the RND superfamily
D2B33_RS21450	COG5522	Integral membrane protein (intg_mem_TP0381)
D2B33_RS21455	COG2271	Major facilitator Superfamily
D2B33_RS21460	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_RS21465	COG0800	Aldolase
D2B33_RS21470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_RS21480	COG2234	aminopeptidase activity
D2B33_RS21485	COG0477	Major facilitator Superfamily
D2B33_RS21500	COG2357	RelA SpoT domain protein
D2B33_RS21515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_RS21520	COG1696	Membrane protein involved in D-alanine export
D2B33_RS21525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2B33_RS21530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D2B33_RS21535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_RS21540	COG2814	Major facilitator Superfamily
D2B33_RS21545	COG1486	melibiose metabolic process
D2B33_RS21550	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_RS21555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS21560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS21565	COG3711	transcriptional antiterminator
D2B33_RS21565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_RS21570	COG2094	Belongs to the DNA glycosylase MPG family
D2B33_RS21580	COG0372	Belongs to the citrate synthase family
D2B33_RS21585	COG2079	MmgE PrpD family protein
D2B33_RS21590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D2B33_RS21605	COG1132	(ABC) transporter
D2B33_RS21610	COG2755	lipolytic protein G-D-S-L family
D2B33_RS21625	COG2814	Major facilitator Superfamily
D2B33_RS21630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_RS21635	COG1131	(ABC) transporter
D2B33_RS21655	COG1595	DNA-templated transcription, initiation
D2B33_RS21660	COG2814	Major facilitator Superfamily
D2B33_RS21670	COG0753	catalase activity
D2B33_RS21675	COG0753	catalase activity
D2B33_RS21680	COG0735	belongs to the Fur family
D2B33_RS21685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D2B33_RS21695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D2B33_RS21700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D2B33_RS21705	COG4988	ABC transporter
D2B33_RS21710	COG1294	oxidase, subunit
D2B33_RS21715	COG1271	oxidase subunit
D2B33_RS21720	COG2116	formate transmembrane transporter activity
D2B33_RS21730	COG0281	malic enzyme
D2B33_RS21735	COG1757	Na H antiporter
D2B33_RS21740	COG1027	Aspartate ammonia-lyase
D2B33_RS21745	COG0252	asparaginase activity
D2B33_RS21750	COG1396	sequence-specific DNA binding
D2B33_RS21755	COG2706	6-phosphogluconolactonase activity
D2B33_RS21760	COG0745	RESPONSE REGULATOR receiver
D2B33_RS21765	COG2205	protein histidine kinase activity
D2B33_RS21770	COG1136	(ABC) transporter
D2B33_RS21775	COG0577	efflux transmembrane transporter activity
D2B33_RS21780	COG5294	Protein conserved in bacteria
D2B33_RS21795	COG0726	polysaccharide deacetylase
D2B33_RS21800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_RS21810	COG1215	transferase activity, transferring glycosyl groups
D2B33_RS21815	COG3493	citrate carrier protein
D2B33_RS21820	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_RS21835	COG1368	sulfuric ester hydrolase activity
D2B33_RS21845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_RS21855	COG2235	arginine
D2B33_RS21860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2B33_RS21870	COG0549	Belongs to the carbamate kinase family
D2B33_RS21880	COG2723	6-phospho-beta-galactosidase activity
D2B33_RS21885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_RS21895	COG1595	DNA-templated transcription, initiation
D2B33_RS21905	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2B33_RS21915	COG2223	nitrite transmembrane transporter activity
D2B33_RS21920	COG0395	ABC-type sugar transport system, permease component
D2B33_RS21925	COG1175	transmembrane transport
D2B33_RS21935	COG1609	Transcriptional regulator
D2B33_RS21950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2B33_RS21955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D2B33_RS21960	COG0463	Glycosyl transferase, family 2
D2B33_RS21965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_RS22000	COG1131	(ABC) transporter
D2B33_RS22020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2B33_RS22030	COG3253	May function as heme-dependent peroxidase
D2B33_RS22035	COG0280	phosphate acetyltransferase
D2B33_RS22045	COG1414	Transcriptional regulator
D2B33_RS22070	COG2814	Major facilitator Superfamily
D2B33_RS22095	COG4844	belongs to the
D2B33_RS22100	COG1078	dGTPase activity
D2B33_RS22105	COG3465	dGTPase activity
D2B33_RS22115	COG1942	4-Oxalocrotonate Tautomerase
D2B33_RS22120	COG1994	Peptidase M50
D2B33_RS22130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_RS22135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D2B33_RS22140	COG0010	Belongs to the arginase family
D2B33_RS22145	COG4506	Protein conserved in bacteria
D2B33_RS22150	COG0018	arginyl-trna synthetase
D2B33_RS22160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_RS22165	COG2181	nitrate reductase activity
D2B33_RS22165	COG0247	lactate metabolic process
D2B33_RS22170	COG0183	Belongs to the thiolase family
D2B33_RS22175	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2B33_RS22180	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS22185	COG1960	acyl-CoA dehydrogenase activity
D2B33_RS22190	COG3343	RNA polymerase activity
D2B33_RS22195	COG0504	CTP synthase activity
D2B33_RS22200	COG4821	SIS domain
D2B33_RS22205	COG2204	response regulator
D2B33_RS22210	COG0191	fructose-bisphosphate aldolase activity
D2B33_RS22215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D2B33_RS22220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2B33_RS22225	COG1494	fructose-1,6-bisphosphatase
D2B33_RS22230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D2B33_RS22235	COG0254	rRNA binding
D2B33_RS22240	COG1435	thymidine kinase activity
D2B33_RS22245	COG0281	malic enzyme
D2B33_RS22250	COG0679	Auxin Efflux Carrier
D2B33_RS22255	COG0789	Transcriptional regulator
D2B33_RS22260	COG0346	lactoylglutathione lyase activity
D2B33_RS22265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D2B33_RS22270	COG2890	protein-(glutamine-N5) methyltransferase activity
D2B33_RS22275	COG1609	Transcriptional regulator
D2B33_RS22280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_RS22285	COG0561	phosphatase activity
D2B33_RS22290	COG0673	inositol 2-dehydrogenase activity
D2B33_RS22295	COG0738	Major facilitator superfamily