locus-tag	class	description
I0K14_RS00010	COG0592	DNA-directed DNA polymerase activity
I0K14_RS00015	COG2501	S4 domain
I0K14_RS00025	COG0187	DNA topoisomerase II activity
I0K14_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K14_RS00065	COG0516	GMP reductase activity
I0K14_RS00065	COG0517	IMP dehydrogenase activity
I0K14_RS00070	COG1686	Belongs to the peptidase S11 family
I0K14_RS00100	COG1428	Deoxynucleoside kinase
I0K14_RS00105	COG1428	Deoxynucleoside kinase
I0K14_RS00110	COG1335	isochorismatase
I0K14_RS00115	COG0590	tRNA wobble adenosine to inosine editing
I0K14_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I0K14_RS00180	COG1982	Orn Lys Arg decarboxylase major
I0K14_RS00190	COG0470	DNA polymerase III
I0K14_RS00195	COG1774	PSP1 C-terminal conserved region
I0K14_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I0K14_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I0K14_RS00220	COG2002	toxin-antitoxin pair type II binding
I0K14_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_RS00230	COG0084	hydrolase, TatD family'
I0K14_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I0K14_RS00250	COG4466	Protein conserved in bacteria
I0K14_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0K14_RS00270	COG0251	oxidation-reduction process
I0K14_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0K14_RS00305	COG2002	toxin-antitoxin pair type II binding
I0K14_RS00310	COG2244	polysaccharide biosynthetic process
I0K14_RS00315	COG3956	TIGRFAM MazG family protein
I0K14_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I0K14_RS00340	COG1098	S1 RNA binding domain
I0K14_RS00355	COG2208	phosphoserine phosphatase activity
I0K14_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K14_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0K14_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0K14_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K14_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0K14_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0K14_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I0K14_RS00420	COG1396	sequence-specific DNA binding
I0K14_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K14_RS00515	COG3880	PFAM UvrB UvrC protein
I0K14_RS00525	COG0542	response to heat
I0K14_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I0K14_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
I0K14_RS00560	COG1045	serine acetyltransferase
I0K14_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K14_RS00580	COG3688	RNA-binding protein containing a PIN domain
I0K14_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K14_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
I0K14_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I0K14_RS00625	COG2813	Specifically methylates the guanine in position
I0K14_RS00640	COG1358	cellular component organization or biogenesis
I0K14_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
I0K14_RS00770	COG0201	protein transport
I0K14_RS00780	COG0024	Methionine aminopeptidase
I0K14_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0K14_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I0K14_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0K14_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS00855	COG0489	protein tyrosine kinase activity
I0K14_RS00865	COG2194	sulfuric ester hydrolase activity
I0K14_RS00870	COG0726	polysaccharide deacetylase
I0K14_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I0K14_RS00955	COG4856	YbbR-like protein
I0K14_RS00975	COG0596	Alpha beta hydrolase
I0K14_RS00995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I0K14_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS01025	COG2011	ABC-type metal ion transport system permease component
I0K14_RS01035	COG1464	Belongs to the NlpA lipoprotein family
I0K14_RS01040	COG0604	alcohol dehydrogenase
I0K14_RS01050	COG0277	FAD linked oxidase domain protein
I0K14_RS01055	COG2271	Major facilitator Superfamily
I0K14_RS01065	COG2814	Major facilitator Superfamily
I0K14_RS01085	COG0601	transmembrane transport
I0K14_RS01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_RS01095	COG0444	Belongs to the ABC transporter superfamily
I0K14_RS01100	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS01105	COG4166	transmembrane transport
I0K14_RS01115	COG2207	Transcriptional regulator
I0K14_RS01130	COG4166	transmembrane transport
I0K14_RS01135	COG4166	transmembrane transport
I0K14_RS01140	COG0656	L-ascorbic acid biosynthetic process
I0K14_RS01145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_RS01155	COG4149	molybdate abc transporter
I0K14_RS01160	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K14_RS01165	COG1910	domain protein
I0K14_RS01180	COG0697	spore germination
I0K14_RS01195	COG0204	Acyl-transferase
I0K14_RS01205	COG1609	Transcriptional regulator
I0K14_RS01215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS01225	COG0084	hydrolase, TatD family'
I0K14_RS01230	COG5298	Protein conserved in bacteria
I0K14_RS01255	COG0488	(ABC) transporter
I0K14_RS01270	COG0747	negative chemotaxis
I0K14_RS01275	COG0601	transmembrane transport
I0K14_RS01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_RS01285	COG0444	Belongs to the ABC transporter superfamily
I0K14_RS01290	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS01295	COG0561	phosphatase activity
I0K14_RS01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I0K14_RS01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K14_RS01340	COG0531	amino acid
I0K14_RS01345	COG2814	Major facilitator Superfamily
I0K14_RS01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0K14_RS01365	COG4294	response to UV
I0K14_RS01370	COG0705	Rhomboid family
I0K14_RS01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0K14_RS01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K14_RS01390	COG0864	Transcriptional regulator
I0K14_RS01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
I0K14_RS01400	COG2183	response to ionizing radiation
I0K14_RS01495	COG0802	atpase or kinase
I0K14_RS01500	COG1214	PFAM Peptidase M22, glycoprotease
I0K14_RS01505	COG0456	acetyltransferase
I0K14_RS01515	COG0488	(ABC) transporter
I0K14_RS01530	COG1266	CAAX protease self-immunity
I0K14_RS01550	COG2252	PERMEase
I0K14_RS01560	COG5002	protein histidine kinase activity
I0K14_RS01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K14_RS01615	COG2226	methyltransferase
I0K14_RS01635	COG1215	transferase activity, transferring glycosyl groups
I0K14_RS01670	COG2205	protein histidine kinase activity
I0K14_RS01675	COG0745	RESPONSE REGULATOR receiver
I0K14_RS01700	COG0697	spore germination
I0K14_RS01725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I0K14_RS01730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0K14_RS01735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0K14_RS01745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0K14_RS01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0K14_RS01770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0K14_RS01780	COG0151	Belongs to the GarS family
I0K14_RS01805	COG0210	DNA helicase
I0K14_RS01815	COG4851	CamS sex pheromone cAM373 precursor
I0K14_RS01835	COG1335	isochorismatase
I0K14_RS01840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0K14_RS01845	COG2011	ABC-type metal ion transport system permease component
I0K14_RS01850	COG1464	Belongs to the NlpA lipoprotein family
I0K14_RS01865	COG0003	Pfam Anion-transporting ATPase
I0K14_RS01870	COG1846	Transcriptional regulator
I0K14_RS01875	COG4682	membrane
I0K14_RS01895	COG1597	lipid kinase activity
I0K14_RS01900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0K14_RS01905	COG0546	phosphoglycolate phosphatase activity
I0K14_RS01910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0K14_RS01920	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS01925	COG2076	Multidrug Resistance protein
I0K14_RS01930	COG2309	aminopeptidase activity
I0K14_RS01945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS01955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K14_RS01960	COG5002	protein histidine kinase activity
I0K14_RS01965	COG4807	Protein conserved in bacteria
I0K14_RS01990	COG1757	Na H antiporter
I0K14_RS01995	COG1473	amidohydrolase
I0K14_RS02010	COG0450	alkyl hydroperoxide reductase
I0K14_RS02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS02065	COG0166	Belongs to the GPI family
I0K14_RS02105	COG3541	Predicted nucleotidyltransferase
I0K14_RS02110	COG2814	Major facilitator Superfamily
I0K14_RS02115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_RS02115	COG0723	plastoquinol--plastocyanin reductase activity
I0K14_RS02125	COG0765	amino acid transport
I0K14_RS02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_RS02140	COG0840	transmembrane signaling receptor activity
I0K14_RS02165	COG0549	Belongs to the carbamate kinase family
I0K14_RS02170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_RS02180	COG0277	FAD linked oxidase domain protein
I0K14_RS02185	COG0366	Alpha amylase catalytic
I0K14_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_RS02190	COG1263	PTS System
I0K14_RS02190	COG2190	(PTS) system
I0K14_RS02225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I0K14_RS02240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_RS02250	COG1116	anion transmembrane transporter activity
I0K14_RS02260	COG0488	(ABC) transporter
I0K14_RS02310	COG2270	Major facilitator Superfamily
I0K14_RS02340	COG2310	stress, protein
I0K14_RS02345	COG2310	stress, protein
I0K14_RS02350	COG2310	stress, protein
I0K14_RS02355	COG0861	Integral membrane protein TerC family
I0K14_RS02365	COG3853	Toxic anion resistance protein (TelA)
I0K14_RS02380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I0K14_RS02390	COG1295	ribonuclease BN
I0K14_RS02395	COG2217	Heavy metal translocating P-type atpase
I0K14_RS02400	COG0697	spore germination
I0K14_RS02420	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS02435	COG3871	stress protein (general stress protein 26)
I0K14_RS02440	COG0387	Pfam Sodium calcium exchanger
I0K14_RS02450	COG0535	radical SAM domain protein
I0K14_RS02470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K14_RS02490	COG3829	transcription factor binding
I0K14_RS02500	COG0833	amino acid
I0K14_RS02505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_RS02535	COG1263	PTS System
I0K14_RS02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_RS02540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_RS02555	COG0463	Glycosyl transferase, family 2
I0K14_RS02565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0K14_RS02565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K14_RS02570	COG0463	Glycosyl transferase, family 2
I0K14_RS02585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0K14_RS02605	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_RS02610	COG1090	epimerase
I0K14_RS02640	COG1988	membrane-bound metal-dependent
I0K14_RS02645	COG1194	a g-specific adenine glycosylase
I0K14_RS02670	COG1132	(ABC) transporter
I0K14_RS02675	COG4129	membrane
I0K14_RS02680	COG0067	glutamate synthase
I0K14_RS02680	COG0070	glutamate synthase
I0K14_RS02680	COG0069	glutamate synthase activity
I0K14_RS02690	COG4555	ABC transporter
I0K14_RS02710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0K14_RS02715	COG0735	belongs to the Fur family
I0K14_RS02825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0K14_RS02830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0K14_RS02840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I0K14_RS02850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0K14_RS02860	COG2766	serine protein kinase
I0K14_RS02880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_RS02890	COG1585	Membrane protein implicated in regulation of membrane protease activity
I0K14_RS02895	COG2268	Band 7 protein
I0K14_RS02905	COG3290	protein histidine kinase activity
I0K14_RS02910	COG4565	transcriptional regulatory protein
I0K14_RS02915	COG2851	Citrate transporter
I0K14_RS02940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K14_RS02945	COG3842	ATPase activity
I0K14_RS02950	COG1175	transmembrane transport
I0K14_RS02955	COG0395	ABC-type sugar transport system, permease component
I0K14_RS02965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0K14_RS02970	COG0745	RESPONSE REGULATOR receiver
I0K14_RS02975	COG5002	protein histidine kinase activity
I0K14_RS02985	COG4990	cell redox homeostasis
I0K14_RS02995	COG0697	spore germination
I0K14_RS03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS03010	COG5002	protein histidine kinase activity
I0K14_RS03015	COG0745	RESPONSE REGULATOR receiver
I0K14_RS03020	COG0454	-acetyltransferase
I0K14_RS03020	COG0456	acetyltransferase
I0K14_RS03025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K14_RS03030	COG3383	formate dehydrogenase (NAD+) activity
I0K14_RS03035	COG2427	Protein of unknown function (DUF1641)
I0K14_RS03050	COG0531	amino acid
I0K14_RS03055	COG0640	Transcriptional regulator
I0K14_RS03060	COG2217	Heavy metal translocating P-type atpase
I0K14_RS03065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I0K14_RS03080	COG3227	Zinc metalloprotease (Elastase)
I0K14_RS03100	COG2720	vancomycin resistance protein
I0K14_RS03105	COG1316	TRANSCRIPTIONal
I0K14_RS03110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS03115	COG0346	lactoylglutathione lyase activity
I0K14_RS03120	COG1253	flavin adenine dinucleotide binding
I0K14_RS03125	COG1027	Aspartate ammonia-lyase
I0K14_RS03130	COG1620	l-lactate permease
I0K14_RS03145	COG3104	oligopeptide transport
I0K14_RS03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS03170	COG2226	methyltransferase
I0K14_RS03175	COG0156	8-amino-7-oxononanoate synthase activity
I0K14_RS03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K14_RS03185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I0K14_RS03195	COG4548	von Willebrand factor, type A
I0K14_RS03200	COG0714	Associated with various cellular activities
I0K14_RS03205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_RS03225	COG0531	amino acid
I0K14_RS03230	COG2188	Transcriptional regulator
I0K14_RS03235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_RS03235	COG1263	PTS System
I0K14_RS03240	COG0366	Alpha amylase catalytic
I0K14_RS03255	COG0697	spore germination
I0K14_RS03260	COG4585	Histidine kinase
I0K14_RS03265	COG2197	response regulator
I0K14_RS03270	COG1404	Belongs to the peptidase S8 family
I0K14_RS03285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_RS03290	COG1115	amino acid carrier protein
I0K14_RS03295	COG1126	abc transporter atp-binding protein
I0K14_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_RS03305	COG0765	amino acid transport
I0K14_RS03310	COG0765	amino acid transport
I0K14_RS03315	COG0833	amino acid
I0K14_RS03330	COG1595	DNA-templated transcription, initiation
I0K14_RS03340	COG2378	regulation of single-species biofilm formation
I0K14_RS03345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0K14_RS03350	COG5002	protein histidine kinase activity
I0K14_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
I0K14_RS03380	COG0747	negative chemotaxis
I0K14_RS03390	COG0601	transmembrane transport
I0K14_RS03395	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS03405	COG2271	Major facilitator Superfamily
I0K14_RS03410	COG1846	Transcriptional regulator
I0K14_RS03415	COG0477	Major facilitator Superfamily
I0K14_RS03420	COG1609	Transcriptional regulator
I0K14_RS03425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0K14_RS03440	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS03445	COG1879	ABC-type sugar transport system periplasmic component
I0K14_RS03470	COG1063	alcohol dehydrogenase
I0K14_RS03490	COG3568	Endonuclease Exonuclease Phosphatase
I0K14_RS03520	COG0840	transmembrane signaling receptor activity
I0K14_RS03525	COG3583	domain protein
I0K14_RS03525	COG3584	3D domain protein
I0K14_RS03530	COG1476	TRANSCRIPTIONal
I0K14_RS03550	COG3104	oligopeptide transport
I0K14_RS03555	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS03570	COG1113	amino acid transport
I0K14_RS03575	COG2252	PERMEase
I0K14_RS03590	COG2153	protein acetylation
I0K14_RS03600	COG0475	glutathione-regulated potassium exporter activity
I0K14_RS03600	COG0569	domain protein
I0K14_RS03615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0K14_RS03620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0K14_RS03625	COG0833	amino acid
I0K14_RS03630	COG4990	cell redox homeostasis
I0K14_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_RS03650	COG0697	spore germination
I0K14_RS03655	COG0531	amino acid
I0K14_RS03670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_RS03675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_RS03680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_RS03680	COG1918	ferrous iron import across plasma membrane
I0K14_RS03685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K14_RS03690	COG0573	inorganic phosphate transmembrane transporter activity
I0K14_RS03695	COG0581	inorganic phosphate transmembrane transporter activity
I0K14_RS03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K14_RS03825	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I0K14_RS03845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K14_RS03850	COG1116	anion transmembrane transporter activity
I0K14_RS03855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_RS03860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_RS03865	COG0352	thiamine-phosphate diphosphorylase activity
I0K14_RS03870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_RS03875	COG2104	thiamine diphosphate biosynthetic process
I0K14_RS03885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_RS03890	COG0351	phosphomethylpyrimidine kinase
I0K14_RS03930	COG2205	protein histidine kinase activity
I0K14_RS03935	COG2814	Major facilitator Superfamily
I0K14_RS03940	COG1846	Transcriptional regulator
I0K14_RS03955	COG2252	PERMEase
I0K14_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS04020	COG0778	Nitroreductase
I0K14_RS04025	COG2719	SpoVR family
I0K14_RS04035	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0K14_RS04040	COG1937	Protein conserved in bacteria
I0K14_RS04045	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_RS04045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_RS04055	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_RS04060	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_RS04065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_RS04065	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_RS04075	COG2210	Belongs to the sulfur carrier protein TusA family
I0K14_RS04080	COG0730	response to heat
I0K14_RS04090	COG1316	TRANSCRIPTIONal
I0K14_RS04095	COG0604	alcohol dehydrogenase
I0K14_RS04100	COG1283	sodium-dependent phosphate transmembrane transporter activity
I0K14_RS04105	COG2814	Major facilitator Superfamily
I0K14_RS04115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_RS04115	COG3711	transcriptional antiterminator
I0K14_RS04120	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_RS04125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_RS04150	COG3584	3D domain protein
I0K14_RS04150	COG1388	LysM domain
I0K14_RS04155	COG1396	sequence-specific DNA binding
I0K14_RS04165	COG4824	toxin secretion phage lysis holin
I0K14_RS04175	COG1388	LysM domain
I0K14_RS04175	COG0791	NLP P60 protein
I0K14_RS04180	COG3584	3D domain protein
I0K14_RS04180	COG3583	domain protein
I0K14_RS04185	COG0577	efflux transmembrane transporter activity
I0K14_RS04190	COG1136	(ABC) transporter
I0K14_RS04200	COG5522	Integral membrane protein (intg_mem_TP0381)
I0K14_RS04215	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS04220	COG3546	catalase activity
I0K14_RS04255	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS04290	COG0531	amino acid
I0K14_RS04295	COG0475	glutathione-regulated potassium exporter activity
I0K14_RS04305	COG1737	Transcriptional regulator
I0K14_RS04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_RS04315	COG1263	PTS System
I0K14_RS04325	COG2259	Doxx family
I0K14_RS04345	COG1522	sequence-specific DNA binding
I0K14_RS04360	COG2076	Multidrug Resistance protein
I0K14_RS04365	COG1309	transcriptional regulator
I0K14_RS04370	COG2814	Major facilitator Superfamily
I0K14_RS04380	COG1846	Transcriptional regulator
I0K14_RS04385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0K14_RS04390	COG0477	Major facilitator Superfamily
I0K14_RS04395	COG0657	acetylesterase activity
I0K14_RS04400	COG0657	acetylesterase activity
I0K14_RS04410	COG2124	cytochrome p450
I0K14_RS04420	COG1063	alcohol dehydrogenase
I0K14_RS04425	COG1733	regulation of RNA biosynthetic process
I0K14_RS04435	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_RS04440	COG4533	DNA binding
I0K14_RS04445	COG2211	Major facilitator Superfamily
I0K14_RS04455	COG0693	protein deglycase activity
I0K14_RS04460	COG0753	catalase activity
I0K14_RS04470	COG0531	amino acid
I0K14_RS04475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0K14_RS04485	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS04490	COG1132	(ABC) transporter
I0K14_RS04495	COG1132	(ABC) transporter
I0K14_RS04500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_RS04505	COG0765	amino acid transport
I0K14_RS04510	COG1126	abc transporter atp-binding protein
I0K14_RS04525	COG0189	ligase activity
I0K14_RS04555	COG0028	Belongs to the TPP enzyme family
I0K14_RS04560	COG3527	Alpha-acetolactate decarboxylase
I0K14_RS04570	COG0561	phosphatase activity
I0K14_RS04580	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_RS04580	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS04585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K14_RS04605	COG0659	secondary active sulfate transmembrane transporter activity
I0K14_RS04620	COG0653	protein targeting
I0K14_RS04625	COG2244	polysaccharide biosynthetic process
I0K14_RS04635	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS04640	COG4196	transglutaminase domain protein
I0K14_RS04655	COG1696	Membrane protein involved in D-alanine export
I0K14_RS04670	COG1024	Enoyl-CoA hydratase
I0K14_RS04690	COG1363	Peptidase, m42
I0K14_RS04730	COG0601	transmembrane transport
I0K14_RS04735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_RS04740	COG0444	Belongs to the ABC transporter superfamily
I0K14_RS04745	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS04750	COG0477	Major facilitator Superfamily
I0K14_RS04755	COG3290	protein histidine kinase activity
I0K14_RS04760	COG4565	transcriptional regulatory protein
I0K14_RS04765	COG3181	Tripartite tricarboxylate transporter family receptor
I0K14_RS04800	COG1396	sequence-specific DNA binding
I0K14_RS04840	COG4974	Belongs to the 'phage' integrase family
I0K14_RS04855	COG0789	Transcriptional regulator
I0K14_RS04855	COG4978	Transcriptional regulator
I0K14_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
I0K14_RS04895	COG0477	Major facilitator Superfamily
I0K14_RS04970	COG1183	phosphatidylcholine synthase activity
I0K14_RS04990	COG2376	Dihydroxyacetone kinase
I0K14_RS05000	COG2376	Dihydroxyacetone kinase
I0K14_RS05090	COG3237	CsbD-like
I0K14_RS05115	COG1191	sigma factor activity
I0K14_RS05125	COG2208	phosphoserine phosphatase activity
I0K14_RS05130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K14_RS05135	COG2198	Histidine kinase
I0K14_RS05135	COG0784	Response regulator, receiver
I0K14_RS05135	COG2205	protein histidine kinase activity
I0K14_RS05180	COG2814	Major facilitator Superfamily
I0K14_RS05210	COG0420	3'-5' exonuclease activity
I0K14_RS05215	COG4717	serine-type aminopeptidase activity
I0K14_RS05235	COG0346	lactoylglutathione lyase activity
I0K14_RS05240	COG0346	lactoylglutathione lyase activity
I0K14_RS05245	COG0457	Tetratricopeptide repeat
I0K14_RS05255	COG2267	carboxylic ester hydrolase activity
I0K14_RS05270	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K14_RS05275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I0K14_RS05285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0K14_RS05310	COG0772	Belongs to the SEDS family
I0K14_RS05325	COG0477	Major facilitator Superfamily
I0K14_RS05330	COG0477	Major facilitator Superfamily
I0K14_RS05340	COG3973	AAA domain
I0K14_RS05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_RS05365	COG4980	gas vesicle protein
I0K14_RS05370	COG0537	adenosine 5'-monophosphoramidase activity
I0K14_RS05375	COG1131	(ABC) transporter
I0K14_RS05380	COG4473	ABC transporter
I0K14_RS05450	COG1309	transcriptional regulator
I0K14_RS05460	COG3402	PFAM membrane-flanked domain
I0K14_RS05465	COG3428	Bacterial PH domain
I0K14_RS05495	COG3402	PFAM membrane-flanked domain
I0K14_RS05500	COG3428	Bacterial PH domain
I0K14_RS05510	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_RS05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_RS05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K14_RS05555	COG1309	transcriptional regulator
I0K14_RS05560	COG1511	domain protein
I0K14_RS05580	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I0K14_RS05590	COG2378	regulation of single-species biofilm formation
I0K14_RS05595	COG1609	Transcriptional regulator
I0K14_RS05605	COG1234	tRNA 3'-trailer cleavage
I0K14_RS05610	COG0095	Lipoate-protein ligase
I0K14_RS05620	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS05665	COG1408	metallophosphoesterase
I0K14_RS05670	COG1078	dGTPase activity
I0K14_RS05680	COG1595	DNA-templated transcription, initiation
I0K14_RS05685	COG3708	Transcriptional regulator
I0K14_RS05685	COG2207	Transcriptional regulator
I0K14_RS05690	COG2205	protein histidine kinase activity
I0K14_RS05695	COG0745	RESPONSE REGULATOR receiver
I0K14_RS05720	COG0501	Belongs to the peptidase M48B family
I0K14_RS05725	COG0697	spore germination
I0K14_RS05745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I0K14_RS05750	COG2224	Isocitrate lyase
I0K14_RS05775	COG4903	ComK protein
I0K14_RS05780	COG4585	Histidine kinase
I0K14_RS05785	COG2197	response regulator
I0K14_RS05795	COG0398	Pfam SNARE associated Golgi protein
I0K14_RS05855	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K14_RS05880	COG0367	asparagine synthase
I0K14_RS05885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I0K14_RS05890	COG0753	catalase activity
I0K14_RS05895	COG0004	ammonium transporteR
I0K14_RS05915	COG2996	Protein conserved in bacteria
I0K14_RS05920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_RS05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS05945	COG0561	phosphatase activity
I0K14_RS05965	COG2267	carboxylic ester hydrolase activity
I0K14_RS05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_RS05985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0K14_RS05990	COG5504	Zn-dependent protease
I0K14_RS06000	COG0180	Tryptophanyl-tRNA synthetase
I0K14_RS06010	COG4166	transmembrane transport
I0K14_RS06015	COG0601	transmembrane transport
I0K14_RS06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_RS06025	COG0444	Belongs to the ABC transporter superfamily
I0K14_RS06030	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS06035	COG0534	Mate efflux family protein
I0K14_RS06040	COG4166	transmembrane transport
I0K14_RS06055	COG0861	Integral membrane protein TerC family
I0K14_RS06060	COG4862	establishment of competence for transformation
I0K14_RS06065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_RS06075	COG1164	Oligoendopeptidase f
I0K14_RS06090	COG2346	COG2346, Truncated hemoglobins
I0K14_RS06095	COG4116	CYTH
I0K14_RS06105	COG2357	RelA SpoT domain protein
I0K14_RS06115	COG0564	pseudouridine synthase activity
I0K14_RS06130	COG0772	Belongs to the SEDS family
I0K14_RS06135	COG1216	Glycosyl transferase, family 2
I0K14_RS06135	COG0463	Glycosyl transferase, family 2
I0K14_RS06155	COG0463	Glycosyl transferase, family 2
I0K14_RS06155	COG0457	Tetratricopeptide repeat
I0K14_RS06175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I0K14_RS06190	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0K14_RS06235	COG2153	protein acetylation
I0K14_RS06245	COG2382	esterase
I0K14_RS06260	COG5492	domain, Protein
I0K14_RS06265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_RS06275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0K14_RS06275	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K14_RS06320	COG1620	l-lactate permease
I0K14_RS06325	COG5634	Uncharacterized conserved protein (DUF2278)
I0K14_RS06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_RS06395	COG1476	TRANSCRIPTIONal
I0K14_RS06445	COG1686	Belongs to the peptidase S11 family
I0K14_RS06450	COG0681	Belongs to the peptidase S26 family
I0K14_RS06470	COG1396	sequence-specific DNA binding
I0K14_RS06485	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS06495	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0K14_RS06500	COG1177	transmembrane transport
I0K14_RS06505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I0K14_RS06515	COG2409	Drug exporters of the RND superfamily
I0K14_RS06525	COG0564	pseudouridine synthase activity
I0K14_RS06535	COG2340	Cysteine-rich secretory protein family
I0K14_RS06540	COG0247	lactate metabolic process
I0K14_RS06545	COG0277	FAD linked oxidase domain protein
I0K14_RS06550	COG3835	regulator
I0K14_RS06560	COG0745	RESPONSE REGULATOR receiver
I0K14_RS06565	COG5002	protein histidine kinase activity
I0K14_RS06570	COG2186	Transcriptional regulator
I0K14_RS06590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I0K14_RS06600	COG2116	formate transmembrane transporter activity
I0K14_RS06605	COG0861	Integral membrane protein TerC family
I0K14_RS06610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_RS06620	COG2030	dehydratase
I0K14_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS06645	COG3243	poly(R)-hydroxyalkanoic acid synthase
I0K14_RS06655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_RS06670	COG1840	ABC-type Fe3 transport system, periplasmic component
I0K14_RS06675	COG3842	ATPase activity
I0K14_RS06700	COG1349	DNA-binding transcription factor activity
I0K14_RS06710	COG0235	Class ii aldolase
I0K14_RS06720	COG2861	carbohydrate metabolic process
I0K14_RS06730	COG3852	Histidine kinase
I0K14_RS06735	COG1846	Transcriptional regulator
I0K14_RS06745	COG2318	DinB family
I0K14_RS06750	COG5002	protein histidine kinase activity
I0K14_RS06760	COG0720	synthase
I0K14_RS06775	COG4873	Protein conserved in bacteria
I0K14_RS06805	COG1780	Probably involved in ribonucleotide reductase function
I0K14_RS06820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0K14_RS06825	COG1725	Transcriptional regulator
I0K14_RS06830	COG1131	(ABC) transporter
I0K14_RS06840	COG1131	(ABC) transporter
I0K14_RS06845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_RS06850	COG1266	CAAX protease self-immunity
I0K14_RS06860	COG1522	sequence-specific DNA binding
I0K14_RS06870	COG1335	isochorismatase
I0K14_RS06880	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_RS06885	COG2070	2-Nitropropane dioxygenase
I0K14_RS06890	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K14_RS06900	COG1696	Membrane protein involved in D-alanine export
I0K14_RS06925	COG0716	FMN binding
I0K14_RS06940	COG3173	Aminoglycoside phosphotransferase
I0K14_RS06980	COG1846	Transcriptional regulator
I0K14_RS06990	COG1301	dicarboxylic acid transport
I0K14_RS06995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_RS07000	COG4709	membrane
I0K14_RS07005	COG3874	Sporulation protein YtfJ
I0K14_RS07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_RS07030	COG0028	Belongs to the TPP enzyme family
I0K14_RS07035	COG0440	acetolactate synthase activity
I0K14_RS07125	COG1183	phosphatidylcholine synthase activity
I0K14_RS07130	COG1368	sulfuric ester hydrolase activity
I0K14_RS07140	COG0019	diaminopimelate decarboxylase activity
I0K14_RS07160	COG0529	Catalyzes the synthesis of activated sulfate
I0K14_RS07165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K14_RS07185	COG1648	precorrin-2 dehydrogenase activity
I0K14_RS07190	COG0733	neurotransmitter:sodium symporter activity
I0K14_RS07215	COG1757	Na H antiporter
I0K14_RS07230	COG4758	membrane
I0K14_RS07235	COG4585	Histidine kinase
I0K14_RS07240	COG2197	response regulator
I0K14_RS07250	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS07260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K14_RS07300	COG0730	response to heat
I0K14_RS07305	COG0306	phosphate transporter
I0K14_RS07310	COG1392	Phosphate transport regulator
I0K14_RS07315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_RS07330	COG3852	Histidine kinase
I0K14_RS07335	COG1801	Protein of unknown function DUF72
I0K14_RS07345	COG0582	viral genome integration into host DNA
I0K14_RS07350	COG5002	protein histidine kinase activity
I0K14_RS07365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I0K14_RS07365	COG0392	lysyltransferase activity
I0K14_RS07380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_RS07385	COG1686	Belongs to the peptidase S11 family
I0K14_RS07390	COG2715	membrane protein required for spore maturation
I0K14_RS07395	COG0700	Nucleoside recognition
I0K14_RS07400	COG1187	pseudouridine synthase activity
I0K14_RS07410	COG1333	cytochrome c biogenesis protein
I0K14_RS07415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K14_RS07420	COG0745	RESPONSE REGULATOR receiver
I0K14_RS07425	COG5002	protein histidine kinase activity
I0K14_RS07430	COG2096	Adenosyltransferase
I0K14_RS07435	COG4942	peptidase
I0K14_RS07445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I0K14_RS07450	COG1141	Ferredoxin
I0K14_RS07460	COG0514	ATP-dependent DNA helicase (RecQ)
I0K14_RS07465	COG1266	CAAX protease self-immunity
I0K14_RS07475	COG1408	metallophosphoesterase
I0K14_RS07485	COG4862	establishment of competence for transformation
I0K14_RS07490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0K14_RS07510	COG0492	ferredoxin-NADP+ reductase activity
I0K14_RS07585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_RS07600	COG0142	geranyltranstransferase activity
I0K14_RS07610	COG0142	geranyltranstransferase activity
I0K14_RS07630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0K14_RS07635	COG0457	Tetratricopeptide repeat
I0K14_RS07655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K14_RS07660	COG2010	Cytochrome c
I0K14_RS07660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K14_RS07665	COG4347	Protein of unknown function (DUF1405)
I0K14_RS07680	COG2738	Putative neutral zinc metallopeptidase
I0K14_RS07690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS07695	COG1694	Mazg nucleotide pyrophosphohydrolase
I0K14_RS07710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K14_RS07715	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS07750	COG1199	ATP-dependent helicase activity
I0K14_RS07750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0K14_RS07770	COG3935	DnaD domain protein
I0K14_RS07775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I0K14_RS07785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_RS07785	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K14_RS07845	COG0116	Belongs to the methyltransferase superfamily
I0K14_RS07855	COG1199	ATP-dependent helicase activity
I0K14_RS07860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I0K14_RS07880	COG2233	PERMEase
I0K14_RS07885	COG2311	Membrane
I0K14_RS07890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_RS07900	COG0456	acetyltransferase
I0K14_RS07935	COG0754	glutathionylspermidine amidase activity
I0K14_RS07950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_RS07975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K14_RS07990	COG1215	transferase activity, transferring glycosyl groups
I0K14_RS07995	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS08010	COG0454	-acetyltransferase
I0K14_RS08030	COG0328	RNA-DNA hybrid ribonuclease activity
I0K14_RS08065	COG3403	YqcI/YcgG family
I0K14_RS08070	COG1280	lysine exporter protein (LysE YggA)
I0K14_RS08085	COG3162	membrane
I0K14_RS08090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_RS08095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_RS08105	COG0475	glutathione-regulated potassium exporter activity
I0K14_RS08110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_RS08115	COG4978	Transcriptional regulator
I0K14_RS08115	COG0789	Transcriptional regulator
I0K14_RS08125	COG2323	membrane
I0K14_RS08130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I0K14_RS08160	COG2814	Major facilitator Superfamily
I0K14_RS08170	COG2814	Major facilitator Superfamily
I0K14_RS08190	COG1923	regulation of RNA biosynthetic process
I0K14_RS08200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K14_RS08205	COG1360	Flagellar Motor Protein
I0K14_RS08210	COG2201	protein-glutamate methylesterase activity
I0K14_RS08215	COG2198	Histidine kinase
I0K14_RS08215	COG0643	Histidine kinase
I0K14_RS08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_RS08220	COG1776	CheC inhibitor of MCP methylation
I0K14_RS08235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K14_RS08255	COG1256	bacterial-type flagellum assembly
I0K14_RS08260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_RS08280	COG1815	bacterial-type flagellum-dependent cell motility
I0K14_RS08285	COG1558	bacterial-type flagellum-dependent cell motility
I0K14_RS08295	COG1766	The M ring may be actively involved in energy transduction
I0K14_RS08300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_RS08310	COG1157	protein secretion by the type III secretion system
I0K14_RS08345	COG0835	chemotaxis
I0K14_RS08345	COG0784	Response regulator, receiver
I0K14_RS08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_RS08360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_RS08365	COG0741	lytic transglycosylase activity
I0K14_RS08375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_RS08380	COG1776	CheC inhibitor of MCP methylation
I0K14_RS08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_RS08390	COG1338	Plays a role in the flagellum-specific transport system
I0K14_RS08395	COG1987	bacterial-type flagellum assembly
I0K14_RS08405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K14_RS08410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K14_RS08415	COG1419	protein localization to endoplasmic reticulum
I0K14_RS08420	COG4786	Flagellar basal body rod
I0K14_RS08455	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_RS08470	COG3764	Sortase (surface protein transpeptidase)
I0K14_RS08475	COG3764	Sortase (surface protein transpeptidase)
I0K14_RS08500	COG0583	DNA-binding transcription factor activity
I0K14_RS08505	COG3842	ATPase activity
I0K14_RS08510	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K14_RS08520	COG1234	tRNA 3'-trailer cleavage
I0K14_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS08555	COG1686	Belongs to the peptidase S11 family
I0K14_RS08565	COG0406	alpha-ribazole phosphatase activity
I0K14_RS08585	COG1846	Transcriptional regulator
I0K14_RS08595	COG0367	asparagine synthase
I0K14_RS08625	COG1802	Transcriptional regulator
I0K14_RS08630	COG0697	spore germination
I0K14_RS08635	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS08635	COG1216	Glycosyl transferase, family 2
I0K14_RS08640	COG1757	Na H antiporter
I0K14_RS08645	COG0114	fumarate hydratase activity
I0K14_RS08660	COG0534	Mate efflux family protein
I0K14_RS08665	COG3340	Belongs to the peptidase S51 family
I0K14_RS08705	COG2733	membrane
I0K14_RS08740	COG1131	(ABC) transporter
I0K14_RS08755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_RS08760	COG0528	UMP kinase activity
I0K14_RS08770	COG1027	Aspartate ammonia-lyase
I0K14_RS08775	COG0281	malic enzyme
I0K14_RS08780	COG4191	Histidine kinase
I0K14_RS08785	COG0784	Response regulator, receiver
I0K14_RS08790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS08860	COG2814	Major facilitator Superfamily
I0K14_RS08875	COG3842	ATPase activity
I0K14_RS08880	COG2508	Transcriptional regulator
I0K14_RS08890	COG1175	transmembrane transport
I0K14_RS08895	COG0395	ABC-type sugar transport system, permease component
I0K14_RS08905	COG2188	Transcriptional regulator
I0K14_RS08910	COG2222	sugar isomerase
I0K14_RS08925	COG1105	Belongs to the carbohydrate kinase PfkB family
I0K14_RS08940	COG1695	Transcriptional regulator
I0K14_RS08950	COG0477	Major facilitator Superfamily
I0K14_RS08955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_RS08965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K14_RS08970	COG4166	transmembrane transport
I0K14_RS08975	COG2223	nitrite transmembrane transporter activity
I0K14_RS08980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_RS08995	COG2244	polysaccharide biosynthetic process
I0K14_RS09000	COG0733	neurotransmitter:sodium symporter activity
I0K14_RS09010	COG5566	PFAM Mor transcription activator
I0K14_RS09015	COG2323	membrane
I0K14_RS09030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_RS09035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_RS09040	COG0028	Belongs to the TPP enzyme family
I0K14_RS09045	COG0440	acetolactate synthase activity
I0K14_RS09050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I0K14_RS09060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0K14_RS09085	COG2814	Major facilitator Superfamily
I0K14_RS09090	COG3384	dioxygenase
I0K14_RS09100	COG3279	Response regulator of the LytR AlgR family
I0K14_RS09105	COG0427	acetyl-CoA hydrolase
I0K14_RS09125	COG1073	alpha beta
I0K14_RS09130	COG4166	transmembrane transport
I0K14_RS09165	COG0535	radical SAM domain protein
I0K14_RS09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS09175	COG0745	RESPONSE REGULATOR receiver
I0K14_RS09195	COG1914	H( )-stimulated, divalent metal cation uptake system
I0K14_RS09210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K14_RS09215	COG0531	amino acid
I0K14_RS09240	COG2390	Transcriptional regulator
I0K14_RS09250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS09255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I0K14_RS09265	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K14_RS09275	COG0006	proline dipeptidase activity
I0K14_RS09290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K14_RS09315	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS09325	COG2372	response to copper ion
I0K14_RS09325	COG1276	copper resistance
I0K14_RS09330	COG4549	nuclear export factor GLE1
I0K14_RS09340	COG0697	spore germination
I0K14_RS09345	COG0583	DNA-binding transcription factor activity
I0K14_RS09350	COG1959	2 iron, 2 sulfur cluster binding
I0K14_RS09355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K14_RS09360	COG0778	Nitroreductase
I0K14_RS09370	COG0628	permease
I0K14_RS09380	COG1231	oxidoreductase activity
I0K14_RS09385	COG0523	cobalamin synthesis protein
I0K14_RS09395	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS09400	COG2030	dehydratase
I0K14_RS09405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_RS09415	COG0411	ABC transporter
I0K14_RS09445	COG1942	4-Oxalocrotonate Tautomerase
I0K14_RS09465	COG1271	oxidase subunit
I0K14_RS09470	COG1294	oxidase, subunit
I0K14_RS09475	COG4988	ABC transporter
I0K14_RS09480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I0K14_RS09490	COG1216	Glycosyl transferase, family 2
I0K14_RS09530	COG1686	Belongs to the peptidase S11 family
I0K14_RS09545	COG0791	NLP P60 protein
I0K14_RS09545	COG1388	LysM domain
I0K14_RS09555	COG1132	(ABC) transporter
I0K14_RS09560	COG0745	RESPONSE REGULATOR receiver
I0K14_RS09565	COG5002	protein histidine kinase activity
I0K14_RS09575	COG0300	oxidoreductase activity
I0K14_RS09595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I0K14_RS09605	COG0460	homoserine dehydrogenase
I0K14_RS09630	COG1316	TRANSCRIPTIONal
I0K14_RS09650	COG1285	pathogenesis
I0K14_RS09655	COG1247	-acetyltransferase
I0K14_RS09665	COG2814	Major facilitator Superfamily
I0K14_RS09670	COG1279	arginine transmembrane transporter activity
I0K14_RS09680	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K14_RS09715	COG0577	efflux transmembrane transporter activity
I0K14_RS09720	COG2002	toxin-antitoxin pair type II binding
I0K14_RS09725	COG1404	Belongs to the peptidase S8 family
I0K14_RS09730	COG0640	Transcriptional regulator
I0K14_RS09735	COG0667	Aldo Keto reductase
I0K14_RS09740	COG2814	Major facilitator Superfamily
I0K14_RS09765	COG0840	transmembrane signaling receptor activity
I0K14_RS09780	COG3949	Membrane
I0K14_RS09785	COG0783	Belongs to the Dps family
I0K14_RS09800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_RS09810	COG1231	oxidoreductase activity
I0K14_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS09820	COG4989	oxidoreductase activity
I0K14_RS09825	COG0523	cobalamin synthesis protein
I0K14_RS09830	COG0456	acetyltransferase
I0K14_RS09850	COG3443	Belongs to the bacterial solute-binding protein 9 family
I0K14_RS09850	COG0803	Belongs to the bacterial solute-binding protein 9 family
I0K14_RS09860	COG0702	epimerase
I0K14_RS09870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K14_RS09880	COG4166	transmembrane transport
I0K14_RS09895	COG0406	alpha-ribazole phosphatase activity
I0K14_RS09905	COG5337	Spore coat protein CotH
I0K14_RS09910	COG1051	belongs to the nudix hydrolase family
I0K14_RS09915	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS09920	COG2244	polysaccharide biosynthetic process
I0K14_RS09930	COG0701	Predicted permease
I0K14_RS09935	COG3689	TIGRFAM TIGR03943 family protein
I0K14_RS09940	COG1607	acyl-coa hydrolase
I0K14_RS09950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_RS09965	COG0702	epimerase
I0K14_RS09970	COG2839	Protein conserved in bacteria
I0K14_RS09975	COG1253	flavin adenine dinucleotide binding
I0K14_RS09990	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_RS10015	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS10025	COG1876	peptidase activity
I0K14_RS10035	COG0154	amidase activity
I0K14_RS10040	COG2211	Major facilitator Superfamily
I0K14_RS10065	COG0561	phosphatase activity
I0K14_RS10075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K14_RS10080	COG4106	trans-aconitate 2-methyltransferase activity
I0K14_RS10095	COG1819	glycosyl
I0K14_RS10100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS10105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS10135	COG0456	acetyltransferase
I0K14_RS10160	COG3874	Sporulation protein YtfJ
I0K14_RS10185	COG2226	methyltransferase
I0K14_RS10205	COG1082	Xylose isomerase domain protein TIM barrel
I0K14_RS10210	COG0346	lactoylglutathione lyase activity
I0K14_RS10220	COG0604	alcohol dehydrogenase
I0K14_RS10225	COG1595	DNA-templated transcription, initiation
I0K14_RS10240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K14_RS10240	COG0426	domain, Protein
I0K14_RS10250	COG0386	Belongs to the glutathione peroxidase family
I0K14_RS10255	COG1305	Transglutaminase-like
I0K14_RS10260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I0K14_RS10265	COG0714	Associated with various cellular activities
I0K14_RS10280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I0K14_RS10285	COG1140	nitrate reductase beta subunit
I0K14_RS10290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I0K14_RS10295	COG2181	nitrate reductase activity
I0K14_RS10300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_RS10305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K14_RS10310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_RS10315	COG0303	'Molybdopterin
I0K14_RS10330	COG2223	nitrite transmembrane transporter activity
I0K14_RS10345	COG1648	precorrin-2 dehydrogenase activity
I0K14_RS10355	COG1587	Uroporphyrinogen-III synthase
I0K14_RS10355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0K14_RS10360	COG2146	nitrite reductase [NAD(P)H] activity
I0K14_RS10365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K14_RS10370	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I0K14_RS10395	COG2359	stage V sporulation protein S
I0K14_RS10415	COG1418	mRNA catabolic process
I0K14_RS10420	COG0488	(ABC) transporter
I0K14_RS10435	COG0629	single-stranded DNA binding
I0K14_RS10450	COG1413	lyase activity
I0K14_RS10465	COG2521	methyltransferase
I0K14_RS10465	COG2136	Putative SAM-dependent methyltransferase
I0K14_RS10485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I0K14_RS10500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0K14_RS10505	COG0017	Asparaginyl-tRNA synthetase
I0K14_RS10525	COG1674	ftsk spoiiie
I0K14_RS10550	COG5444	nuclease activity
I0K14_RS10595	COG0733	neurotransmitter:sodium symporter activity
I0K14_RS10620	COG2610	gluconate transmembrane transporter activity
I0K14_RS10625	COG1454	alcohol dehydrogenase
I0K14_RS10630	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_RS10640	COG0456	acetyltransferase
I0K14_RS10645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I0K14_RS10655	COG1131	(ABC) transporter
I0K14_RS10660	COG4473	ABC transporter
I0K14_RS10670	COG0546	phosphoglycolate phosphatase activity
I0K14_RS10685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_RS10690	COG3250	beta-galactosidase activity
I0K14_RS10705	COG0768	penicillin binding
I0K14_RS10715	COG0204	Acyl-transferase
I0K14_RS10720	COG1272	protein, Hemolysin III
I0K14_RS10730	COG0805	protein transport
I0K14_RS10740	COG1307	EDD domain protein, DegV family
I0K14_RS10745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I0K14_RS10750	COG1999	signal sequence binding
I0K14_RS10755	COG0071	Belongs to the small heat shock protein (HSP20) family
I0K14_RS10760	COG0367	asparagine synthase
I0K14_RS10780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_RS10800	COG1335	isochorismatase
I0K14_RS10805	COG1051	belongs to the nudix hydrolase family
I0K14_RS10810	COG0071	Belongs to the small heat shock protein (HSP20) family
I0K14_RS10815	COG0668	transmembrane transport
I0K14_RS10820	COG2203	Gaf domain
I0K14_RS10820	COG4585	Histidine kinase
I0K14_RS10825	COG2197	response regulator
I0K14_RS10840	COG1064	alcohol dehydrogenase
I0K14_RS10865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I0K14_RS10900	COG0517	IMP dehydrogenase activity
I0K14_RS10900	COG1125	glycine betaine transport
I0K14_RS10905	COG1174	glycine betaine transport
I0K14_RS10940	COG1253	flavin adenine dinucleotide binding
I0K14_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS10950	COG5506	Protein of unknown function (DUF1694)
I0K14_RS10965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_RS10970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0K14_RS10975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0K14_RS10980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_RS10985	COG0456	acetyltransferase
I0K14_RS10990	COG3829	transcription factor binding
I0K14_RS10995	COG1509	lysine 2,3-aminomutase activity
I0K14_RS11030	COG0515	serine threonine protein kinase
I0K14_RS11030	COG4991	sh3 domain protein
I0K14_RS11030	COG3064	Membrane
I0K14_RS11035	COG4326	sporulation control protein
I0K14_RS11040	COG0671	phosphoesterase, PA-phosphatase related
I0K14_RS11045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K14_RS11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_RS11060	COG5484	DNA packaging
I0K14_RS11060	COG3728	DNA packaging
I0K14_RS11090	COG1595	DNA-templated transcription, initiation
I0K14_RS11125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_RS11165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_RS11165	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K14_RS11175	COG2814	Major facilitator Superfamily
I0K14_RS11180	COG4841	protein insertion into membrane
I0K14_RS11185	COG0372	Belongs to the citrate synthase family
I0K14_RS11190	COG2079	MmgE PrpD family protein
I0K14_RS11195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I0K14_RS11200	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS11205	COG2084	Dehydrogenase
I0K14_RS11215	COG1280	lysine exporter protein (LysE YggA)
I0K14_RS11220	COG1024	Enoyl-CoA hydratase
I0K14_RS11235	COG0420	3'-5' exonuclease activity
I0K14_RS11265	COG2223	nitrite transmembrane transporter activity
I0K14_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS11275	COG1169	isochorismate synthase
I0K14_RS11280	COG1021	2,3-dihydroxybenzoate-AMP ligase
I0K14_RS11285	COG1535	isochorismatase
I0K14_RS11285	COG3433	isochorismatase activity
I0K14_RS11290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0K14_RS11295	COG3251	PFAM MbtH domain protein
I0K14_RS11300	COG2814	Major facilitator Superfamily
I0K14_RS11315	COG0776	regulation of translation
I0K14_RS11325	COG2318	DinB family
I0K14_RS11335	COG1115	amino acid carrier protein
I0K14_RS11365	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_RS11370	COG1187	pseudouridine synthase activity
I0K14_RS11375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K14_RS11380	COG1136	(ABC) transporter
I0K14_RS11390	COG0596	Alpha beta hydrolase
I0K14_RS11395	COG2814	Major facilitator Superfamily
I0K14_RS11410	COG0028	Belongs to the TPP enzyme family
I0K14_RS11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS11480	COG1247	-acetyltransferase
I0K14_RS11505	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I0K14_RS11510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K14_RS11520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS11530	COG1278	Cold shock
I0K14_RS11545	COG0010	Belongs to the arginase family
I0K14_RS11550	COG0561	phosphatase activity
I0K14_RS11560	COG1846	Transcriptional regulator
I0K14_RS11565	COG2814	Major facilitator Superfamily
I0K14_RS11570	COG0583	DNA-binding transcription factor activity
I0K14_RS11575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K14_RS11590	COG0583	DNA-binding transcription factor activity
I0K14_RS11595	COG2258	MOSC domain
I0K14_RS11610	COG1132	(ABC) transporter
I0K14_RS11615	COG1132	(ABC) transporter
I0K14_RS11630	COG1396	sequence-specific DNA binding
I0K14_RS11660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0K14_RS11670	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I0K14_RS11675	COG1595	DNA-templated transcription, initiation
I0K14_RS11700	COG1649	PFAM Uncharacterised BCR, COG1649
I0K14_RS11725	COG2971	BadF BadG BcrA BcrD
I0K14_RS11735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I0K14_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS11790	COG1309	transcriptional regulator
I0K14_RS11805	COG0577	efflux transmembrane transporter activity
I0K14_RS11805	COG1136	(ABC) transporter
I0K14_RS11810	COG3615	Tellurite resistance protein tehB
I0K14_RS11810	COG0500	methyltransferase
I0K14_RS11825	COG3961	Belongs to the TPP enzyme family
I0K14_RS11870	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K14_RS11880	COG0110	maltose O-acetyltransferase activity
I0K14_RS11890	COG0768	penicillin binding
I0K14_RS11895	COG1595	DNA-templated transcription, initiation
I0K14_RS11905	COG0768	penicillin binding
I0K14_RS11910	COG0768	penicillin binding
I0K14_RS11915	COG2367	Beta-lactamase
I0K14_RS11920	COG1408	metallophosphoesterase
I0K14_RS11930	COG1131	(ABC) transporter
I0K14_RS11940	COG1309	transcriptional regulator
I0K14_RS11955	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS11960	COG0439	Biotin carboxylase
I0K14_RS11965	COG0511	ligase activity, forming carbon-carbon bonds
I0K14_RS11970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0K14_RS11975	COG1024	Enoyl-CoA hydratase
I0K14_RS11980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0K14_RS11985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_RS12005	COG0572	uridine kinase
I0K14_RS12010	COG1686	Belongs to the peptidase S11 family
I0K14_RS12035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K14_RS12040	COG2910	NAD(P)H-binding
I0K14_RS12060	COG3227	Zinc metalloprotease (Elastase)
I0K14_RS12105	COG2226	methyltransferase
I0K14_RS12130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS12135	COG2368	4-hydroxyphenylacetate
I0K14_RS12155	COG2323	membrane
I0K14_RS12160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K14_RS12180	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I0K14_RS12185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I0K14_RS12190	COG3773	Cell wall hydrolase
I0K14_RS12200	COG0745	RESPONSE REGULATOR receiver
I0K14_RS12205	COG2205	protein histidine kinase activity
I0K14_RS12215	COG0488	(ABC) transporter
I0K14_RS12225	COG1136	(ABC) transporter
I0K14_RS12230	COG0577	efflux transmembrane transporter activity
I0K14_RS12250	COG0460	homoserine dehydrogenase
I0K14_RS12255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS12265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K14_RS12300	COG5444	nuclease activity
I0K14_RS12350	COG2124	cytochrome p450
I0K14_RS12380	COG0561	phosphatase activity
I0K14_RS12415	COG5002	protein histidine kinase activity
I0K14_RS12420	COG0768	penicillin binding
I0K14_RS12425	COG1819	glycosyl
I0K14_RS12430	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_RS12455	COG2205	protein histidine kinase activity
I0K14_RS12465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_RS12470	COG0604	alcohol dehydrogenase
I0K14_RS12475	COG0671	phosphoesterase, PA-phosphatase related
I0K14_RS12480	COG0768	penicillin binding
I0K14_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS12545	COG0693	protein deglycase activity
I0K14_RS12550	COG0456	acetyltransferase
I0K14_RS12560	COG2814	Major facilitator Superfamily
I0K14_RS12575	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_RS12595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS12600	COG0697	spore germination
I0K14_RS12615	COG0494	nUDIX hydrolase
I0K14_RS12625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_RS12635	COG2223	nitrite transmembrane transporter activity
I0K14_RS12650	COG2816	NAD+ diphosphatase activity
I0K14_RS12655	COG0592	DNA-directed DNA polymerase activity
I0K14_RS12660	COG1051	belongs to the nudix hydrolase family
I0K14_RS12690	COG3878	Protein conserved in bacteria
I0K14_RS12710	COG4667	esterase of the alpha-beta hydrolase superfamily
I0K14_RS12750	COG0322	excinuclease ABC activity
I0K14_RS12790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_RS12815	COG1011	Hydrolase
I0K14_RS12835	COG1523	belongs to the glycosyl hydrolase 13 family
I0K14_RS12840	COG3227	Zinc metalloprotease (Elastase)
I0K14_RS12850	COG0346	lactoylglutathione lyase activity
I0K14_RS12855	COG0201	protein transport
I0K14_RS12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS12910	COG2959	enzyme of heme biosynthesis
I0K14_RS12945	COG1309	transcriptional regulator
I0K14_RS12975	COG3284	Transcriptional regulator
I0K14_RS12990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS12995	COG1349	DNA-binding transcription factor activity
I0K14_RS13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K14_RS13015	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_RS13020	COG0022	dehydrogenase e1 component
I0K14_RS13025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS13040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_RS13040	COG0456	acetyltransferase
I0K14_RS13050	COG0494	nUDIX hydrolase
I0K14_RS13075	COG4176	ABC-type proline glycine betaine transport system permease component
I0K14_RS13080	COG0517	IMP dehydrogenase activity
I0K14_RS13080	COG4175	Glycine betaine
I0K14_RS13110	COG2153	protein acetylation
I0K14_RS13115	COG3397	chitin binding
I0K14_RS13120	COG1819	glycosyl
I0K14_RS13140	COG2205	protein histidine kinase activity
I0K14_RS13145	COG2226	methyltransferase
I0K14_RS13150	COG2315	Protein conserved in bacteria
I0K14_RS13160	COG0658	competence protein
I0K14_RS13160	COG2333	competence protein COMEC
I0K14_RS13205	COG3973	AAA domain
I0K14_RS13220	COG2105	PFAM AIG2 family protein
I0K14_RS13225	COG0514	ATP-dependent DNA helicase (RecQ)
I0K14_RS13255	COG4637	Psort location Cytoplasmic, score
I0K14_RS13275	COG3397	chitin binding
I0K14_RS13290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0K14_RS13295	COG1115	amino acid carrier protein
I0K14_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS13305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0K14_RS13315	COG3938	Belongs to the proline racemase family
I0K14_RS13320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_RS13370	COG1078	dGTPase activity
I0K14_RS13375	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS13390	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K14_RS13395	COG0519	Catalyzes the synthesis of GMP from XMP
I0K14_RS13400	COG4166	transmembrane transport
I0K14_RS13410	COG4948	Mandelate Racemase Muconate Lactonizing
I0K14_RS13460	COG2936	dipeptidyl-peptidase activity
I0K14_RS13465	COG5002	protein histidine kinase activity
I0K14_RS13470	COG0745	RESPONSE REGULATOR receiver
I0K14_RS13510	COG1164	Oligoendopeptidase f
I0K14_RS13515	COG0531	amino acid
I0K14_RS13520	COG1522	sequence-specific DNA binding
I0K14_RS13535	COG1307	EDD domain protein, DegV family
I0K14_RS13575	COG2814	Major facilitator Superfamily
I0K14_RS13585	COG1664	Polymer-forming cytoskeletal
I0K14_RS13590	COG0789	Transcriptional regulator
I0K14_RS13595	COG4533	DNA binding
I0K14_RS13600	COG0477	Major facilitator Superfamily
I0K14_RS13600	COG2814	Major facilitator Superfamily
I0K14_RS13620	COG2261	transglycosylase associated protein
I0K14_RS13635	COG2226	methyltransferase
I0K14_RS13675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0K14_RS13685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I0K14_RS13700	COG1131	(ABC) transporter
I0K14_RS13750	COG0628	permease
I0K14_RS13760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_RS13765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_RS13770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_RS13815	COG2746	aminoglycoside 3-N-acetyltransferase activity
I0K14_RS13835	COG0697	spore germination
I0K14_RS13840	COG2318	DinB family
I0K14_RS13860	COG4912	Dna alkylation repair
I0K14_RS13870	COG0346	lactoylglutathione lyase activity
I0K14_RS13900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_RS13905	COG0861	Integral membrane protein TerC family
I0K14_RS13910	COG1368	sulfuric ester hydrolase activity
I0K14_RS13915	COG0488	(ABC) transporter
I0K14_RS13930	COG2409	Drug exporters of the RND superfamily
I0K14_RS13930	COG1033	growth of symbiont in host cell
I0K14_RS13935	COG1309	transcriptional regulator
I0K14_RS13950	COG0287	Prephenate dehydrogenase
I0K14_RS13955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0K14_RS13965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I0K14_RS13965	COG1605	Chorismate mutase
I0K14_RS14000	COG3584	3D domain protein
I0K14_RS14000	COG1388	LysM domain
I0K14_RS14010	COG1309	transcriptional regulator
I0K14_RS14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS14035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS14045	COG2390	Transcriptional regulator
I0K14_RS14050	COG1070	Carbohydrate kinase
I0K14_RS14075	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_RS14090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS14105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_RS14110	COG4187	Peptidase family M20/M25/M40
I0K14_RS14115	COG1414	Transcriptional regulator
I0K14_RS14120	COG0833	amino acid
I0K14_RS14125	COG1690	Belongs to the RtcB family
I0K14_RS14130	COG3239	Fatty acid desaturase
I0K14_RS14140	COG1785	Belongs to the alkaline phosphatase family
I0K14_RS14150	COG3655	Transcriptional regulator
I0K14_RS14165	COG4377	Putative membrane peptidase family (DUF2324)
I0K14_RS14175	COG3279	Response regulator of the LytR AlgR family
I0K14_RS14190	COG0346	lactoylglutathione lyase activity
I0K14_RS14210	COG0714	Associated with various cellular activities
I0K14_RS14230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0K14_RS14235	COG0753	catalase activity
I0K14_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_RS14245	COG1116	anion transmembrane transporter activity
I0K14_RS14260	COG1846	Transcriptional regulator
I0K14_RS14265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I0K14_RS14275	COG1280	lysine exporter protein (LysE YggA)
I0K14_RS14280	COG3403	YqcI/YcgG family
I0K14_RS14315	COG0778	Nitroreductase
I0K14_RS14320	COG1846	Transcriptional regulator
I0K14_RS14335	COG1051	belongs to the nudix hydrolase family
I0K14_RS14340	COG4884	unkown
I0K14_RS14340	COG3831	ATPase activity
I0K14_RS14365	COG0456	acetyltransferase
I0K14_RS14380	COG0697	spore germination
I0K14_RS14385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS14435	COG0730	response to heat
I0K14_RS14445	COG0833	amino acid
I0K14_RS14455	COG4335	DNA alkylation repair
I0K14_RS14530	COG1984	allophanate hydrolase subunit 2
I0K14_RS14535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I0K14_RS14540	COG1414	Transcriptional regulator
I0K14_RS14550	COG3142	Participates in the control of copper homeostasis
I0K14_RS14555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS14560	COG0640	Transcriptional regulator
I0K14_RS14575	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS14590	COG3314	Sporulation integral membrane protein YlbJ
I0K14_RS14610	COG0574	Belongs to the PEP-utilizing enzyme family
I0K14_RS14610	COG3848	Pyruvate phosphate dikinase
I0K14_RS14620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS14640	COG1063	alcohol dehydrogenase
I0K14_RS14650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0K14_RS14655	COG0737	Belongs to the 5'-nucleotidase family
I0K14_RS14660	COG0753	catalase activity
I0K14_RS14665	COG0598	Magnesium transport protein CorA
I0K14_RS14710	COG0415	Belongs to the DNA photolyase family
I0K14_RS14715	COG0288	reversible hydration of carbon dioxide
I0K14_RS14725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K14_RS14730	COG5609	conserved protein (DUF2294)
I0K14_RS14745	COG0697	spore germination
I0K14_RS14755	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K14_RS14760	COG4641	Protein conserved in bacteria
I0K14_RS14765	COG1136	(ABC) transporter
I0K14_RS14770	COG0577	efflux transmembrane transporter activity
I0K14_RS14805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS14815	COG3347	Dehydrogenase
I0K14_RS14825	COG1070	Carbohydrate kinase
I0K14_RS14830	COG0235	Class ii aldolase
I0K14_RS14840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS14850	COG4154	Belongs to the RbsD FucU family
I0K14_RS14865	COG0798	PFAM Bile acid sodium symporter
I0K14_RS14870	COG0346	lactoylglutathione lyase activity
I0K14_RS14875	COG0640	Transcriptional regulator
I0K14_RS14885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0K14_RS14900	COG3320	Male sterility
I0K14_RS14900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K14_RS14905	COG1309	transcriptional regulator
I0K14_RS14915	COG2814	Major facilitator Superfamily
I0K14_RS14920	COG1309	transcriptional regulator
I0K14_RS14955	COG1522	sequence-specific DNA binding
I0K14_RS14970	COG0346	lactoylglutathione lyase activity
I0K14_RS14980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_RS15020	COG2814	Major facilitator Superfamily
I0K14_RS15030	COG4895	conserved protein (DUF2196)
I0K14_RS15055	COG1280	lysine exporter protein (LysE YggA)
I0K14_RS15080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I0K14_RS15095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I0K14_RS15115	COG0577	efflux transmembrane transporter activity
I0K14_RS15135	COG5002	protein histidine kinase activity
I0K14_RS15135	COG3850	Histidine kinase
I0K14_RS15145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS15150	COG2271	Major facilitator Superfamily
I0K14_RS15155	COG1556	Lactate utilization protein
I0K14_RS15160	COG1139	Iron-sulfur cluster binding protein
I0K14_RS15170	COG0583	DNA-binding transcription factor activity
I0K14_RS15185	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_RS15200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0K14_RS15220	COG0662	Cupin 2, conserved barrel domain protein
I0K14_RS15225	COG2207	Transcriptional regulator
I0K14_RS15225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS15240	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_RS15240	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS15270	COG0477	Major facilitator Superfamily
I0K14_RS15285	COG1846	Transcriptional regulator
I0K14_RS15290	COG2814	Major facilitator Superfamily
I0K14_RS15300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_RS15305	COG1131	(ABC) transporter
I0K14_RS15325	COG2076	Multidrug Resistance protein
I0K14_RS15330	COG1309	transcriptional regulator
I0K14_RS15340	COG2031	fatty acid transporter
I0K14_RS15350	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_RS15385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0K14_RS15400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0K14_RS15405	COG1288	antiporter activity
I0K14_RS15430	COG0789	Transcriptional regulator
I0K14_RS15455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0K14_RS15480	COG1733	regulation of RNA biosynthetic process
I0K14_RS15485	COG0778	Nitroreductase
I0K14_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS15515	COG1131	(ABC) transporter
I0K14_RS15540	COG1011	Hydrolase
I0K14_RS15550	COG2365	Tyrosine phosphatase family
I0K14_RS15570	COG0346	lactoylglutathione lyase activity
I0K14_RS15575	COG1940	carbohydrate kinase activity
I0K14_RS15580	COG0110	maltose O-acetyltransferase activity
I0K14_RS15595	COG0628	permease
I0K14_RS15615	COG2226	methyltransferase
I0K14_RS15625	COG0477	Major facilitator Superfamily
I0K14_RS15650	COG1253	flavin adenine dinucleotide binding
I0K14_RS15655	COG0789	Transcriptional regulator
I0K14_RS15695	COG0697	spore germination
I0K14_RS15705	COG1357	PFAM Pentapeptide repeats (8 copies)
I0K14_RS15710	COG3813	Protein conserved in bacteria
I0K14_RS15715	COG2706	6-phosphogluconolactonase activity
I0K14_RS15720	COG1070	Carbohydrate kinase
I0K14_RS15730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0K14_RS15735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I0K14_RS15745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K14_RS15750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K14_RS15755	COG0604	alcohol dehydrogenase
I0K14_RS15760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_RS15770	COG0604	alcohol dehydrogenase
I0K14_RS15770	COG3321	synthase
I0K14_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS15780	COG1733	regulation of RNA biosynthetic process
I0K14_RS15785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0K14_RS15830	COG0656	L-ascorbic acid biosynthetic process
I0K14_RS15835	COG2814	Major facilitator Superfamily
I0K14_RS15850	COG0814	amino acid
I0K14_RS15875	COG1393	Belongs to the ArsC family
I0K14_RS15880	COG1733	regulation of RNA biosynthetic process
I0K14_RS15885	COG2188	Transcriptional regulator
I0K14_RS15890	COG0673	inositol 2-dehydrogenase activity
I0K14_RS15895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0K14_RS15900	COG1733	regulation of RNA biosynthetic process
I0K14_RS15905	COG1733	regulation of RNA biosynthetic process
I0K14_RS15925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS15945	COG0384	phenazine biosynthesis protein PhzF
I0K14_RS15970	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS15975	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_RS15980	COG1733	regulation of RNA biosynthetic process
I0K14_RS16005	COG1191	sigma factor activity
I0K14_RS16025	COG1309	transcriptional regulator
I0K14_RS16065	COG1151	hydroxylamine reductase activity
I0K14_RS16075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS16110	COG2072	flavoprotein involved in K transport
I0K14_RS16155	COG1695	Transcriptional regulator
I0K14_RS16165	COG1113	amino acid transport
I0K14_RS16170	COG2814	Major facilitator Superfamily
I0K14_RS16195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K14_RS16200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_RS16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS16215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS16220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS16225	COG3739	integral membrane protein
I0K14_RS16260	COG0583	DNA-binding transcription factor activity
I0K14_RS16270	COG2890	protein-(glutamine-N5) methyltransferase activity
I0K14_RS16285	COG1193	negative regulation of DNA recombination
I0K14_RS16290	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I0K14_RS16295	COG1164	Oligoendopeptidase f
I0K14_RS16300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_RS16330	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_RS16350	COG0640	Transcriptional regulator
I0K14_RS16355	COG0604	alcohol dehydrogenase
I0K14_RS16365	COG0457	Tetratricopeptide repeat
I0K14_RS16375	COG2808	Putative FMN-binding domain
I0K14_RS16380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_RS16390	COG0385	Bile acid
I0K14_RS16395	COG0277	FAD linked oxidase domain protein
I0K14_RS16425	COG1285	pathogenesis
I0K14_RS16440	COG2514	catechol 2,3-dioxygenase activity
I0K14_RS16445	COG2720	vancomycin resistance protein
I0K14_RS16460	COG0210	DNA helicase
I0K14_RS16465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0K14_RS16485	COG0582	viral genome integration into host DNA
I0K14_RS16535	COG0582	viral genome integration into host DNA
I0K14_RS16570	COG0716	FMN binding
I0K14_RS16580	COG0494	nUDIX hydrolase
I0K14_RS16600	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS16610	COG0165	Argininosuccinate lyase
I0K14_RS16625	COG4145	pantothenate transmembrane transporter activity
I0K14_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS16650	COG1657	PFAM Prenyltransferase squalene oxidase
I0K14_RS16655	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I0K14_RS16660	COG2962	Rard protein
I0K14_RS16665	COG3326	Membrane
I0K14_RS16680	COG0489	protein tyrosine kinase activity
I0K14_RS16690	COG0314	molybdopterin synthase activity
I0K14_RS16695	COG0303	'Molybdopterin
I0K14_RS16700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_RS16705	COG2116	formate transmembrane transporter activity
I0K14_RS16715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K14_RS16720	COG5609	conserved protein (DUF2294)
I0K14_RS16725	COG2427	Protein of unknown function (DUF1641)
I0K14_RS16730	COG3383	formate dehydrogenase (NAD+) activity
I0K14_RS16735	COG0697	spore germination
I0K14_RS16780	COG2226	methyltransferase
I0K14_RS16785	COG4166	transmembrane transport
I0K14_RS16790	COG4166	transmembrane transport
I0K14_RS16795	COG4166	transmembrane transport
I0K14_RS16800	COG1301	dicarboxylic acid transport
I0K14_RS16805	COG1316	TRANSCRIPTIONal
I0K14_RS16825	COG1131	(ABC) transporter
I0K14_RS16835	COG0673	inositol 2-dehydrogenase activity
I0K14_RS16840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K14_RS16845	COG0187	DNA topoisomerase II activity
I0K14_RS16850	COG1832	CoA-binding protein
I0K14_RS16855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_RS16860	COG0745	RESPONSE REGULATOR receiver
I0K14_RS16880	COG4841	protein insertion into membrane
I0K14_RS16885	COG0824	Thioesterase
I0K14_RS16915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_RS16925	COG1132	(ABC) transporter
I0K14_RS16930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0K14_RS16960	COG2211	Major facilitator Superfamily
I0K14_RS16970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0K14_RS16985	COG0183	Belongs to the thiolase family
I0K14_RS16990	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS16995	COG1268	BioY protein
I0K14_RS17000	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS17015	COG1396	sequence-specific DNA binding
I0K14_RS17060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS17070	COG5002	protein histidine kinase activity
I0K14_RS17075	COG0400	carboxylic ester hydrolase activity
I0K14_RS17080	COG0346	lactoylglutathione lyase activity
I0K14_RS17085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_RS17095	COG0069	glutamate synthase activity
I0K14_RS17100	COG1902	pentaerythritol trinitrate reductase activity
I0K14_RS17105	COG1329	Transcriptional regulator
I0K14_RS17110	COG0010	Belongs to the arginase family
I0K14_RS17135	COG2226	methyltransferase
I0K14_RS17175	COG3344	reverse transcriptase
I0K14_RS17185	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K14_RS17190	COG0785	Cytochrome C biogenesis protein
I0K14_RS17200	COG1473	amidohydrolase
I0K14_RS17210	COG1131	(ABC) transporter
I0K14_RS17220	COG0583	DNA-binding transcription factor activity
I0K14_RS17230	COG1346	cytolysis
I0K14_RS17245	COG0730	response to heat
I0K14_RS17255	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_RS17255	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_RS17270	COG1132	(ABC) transporter
I0K14_RS17275	COG1132	(ABC) transporter
I0K14_RS17300	COG3639	organic phosphonate transmembrane transporter activity
I0K14_RS17305	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I0K14_RS17310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_RS17315	COG0737	Belongs to the 5'-nucleotidase family
I0K14_RS17325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I0K14_RS17345	COG1695	Transcriptional regulator
I0K14_RS17350	COG0174	glutamine synthetase
I0K14_RS17355	COG0789	Transcriptional regulator
I0K14_RS17360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I0K14_RS17365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K14_RS17370	COG2860	membrane
I0K14_RS17375	COG0464	growth
I0K14_RS17405	COG1388	LysM domain
I0K14_RS17405	COG3584	3D domain protein
I0K14_RS17410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_RS17410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K14_RS17410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K14_RS17415	COG1105	Belongs to the carbohydrate kinase PfkB family
I0K14_RS17420	COG1349	DNA-binding transcription factor activity
I0K14_RS17425	COG1979	alcohol dehydrogenase
I0K14_RS17430	COG2322	membrane
I0K14_RS17440	COG1113	amino acid transport
I0K14_RS17450	COG1408	metallophosphoesterase
I0K14_RS17455	COG2116	formate transmembrane transporter activity
I0K14_RS17470	COG2217	Heavy metal translocating P-type atpase
I0K14_RS17475	COG2608	mercury ion transmembrane transporter activity
I0K14_RS17480	COG1937	Protein conserved in bacteria
I0K14_RS17490	COG1230	cation diffusion facilitator family transporter
I0K14_RS17510	COG2819	hydrolase of the alpha beta superfamily
I0K14_RS17515	COG1120	ATPase activity
I0K14_RS17520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS17525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS17530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS17540	COG2169	Transcriptional regulator
I0K14_RS17545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K14_RS17550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K14_RS17560	COG2364	Membrane
I0K14_RS17575	COG2267	carboxylic ester hydrolase activity
I0K14_RS17580	COG0346	lactoylglutathione lyase activity
I0K14_RS17585	COG3300	MHYT domain
I0K14_RS17585	COG5001	Diguanylate cyclase
I0K14_RS17620	COG0384	phenazine biosynthesis protein PhzF
I0K14_RS17630	COG1346	cytolysis
I0K14_RS17635	COG1380	Effector of murein hydrolase LrgA
I0K14_RS17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_RS17660	COG1404	Belongs to the peptidase S8 family
I0K14_RS17665	COG3773	Cell wall hydrolase
I0K14_RS17675	COG1368	sulfuric ester hydrolase activity
I0K14_RS17680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_RS17690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I0K14_RS17715	COG1131	(ABC) transporter
I0K14_RS17740	COG4550	Control of competence regulator ComK, YlbF/YmcA
I0K14_RS17750	COG1013	pyruvate-flavodoxin oxidoreductase activity
I0K14_RS17755	COG0674	pyruvate-flavodoxin oxidoreductase activity
I0K14_RS17755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I0K14_RS17765	COG2359	stage V sporulation protein S
I0K14_RS17770	COG1692	metallophosphoesterase
I0K14_RS17775	COG1418	mRNA catabolic process
I0K14_RS17795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0K14_RS17800	COG1426	Protein conserved in bacteria
I0K14_RS17815	COG0300	oxidoreductase activity
I0K14_RS17820	COG0612	Peptidase, M16
I0K14_RS17825	COG0612	Peptidase, M16
I0K14_RS17830	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS17835	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0K14_RS17840	COG3845	ABC transporter
I0K14_RS17845	COG1744	ABC transporter substrate-binding protein PnrA-like
I0K14_RS17850	COG2188	Transcriptional regulator
I0K14_RS17855	COG1674	ftsk spoiiie
I0K14_RS17865	COG0740	serine-type endopeptidase activity
I0K14_RS17870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_RS17880	COG0527	aspartate kinase activity
I0K14_RS17885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K14_RS17890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K14_RS17895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K14_RS17900	COG1873	PFAM PRC-barrel domain
I0K14_RS17905	COG0612	Peptidase, M16
I0K14_RS17910	COG0726	polysaccharide deacetylase
I0K14_RS17925	COG0196	riboflavin kinase activity
I0K14_RS17940	COG1550	Protein conserved in bacteria
I0K14_RS17950	COG1358	cellular component organization or biogenesis
I0K14_RS17955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I0K14_RS17960	COG0195	Participates in both transcription termination and antitermination
I0K14_RS17980	COG0750	zinc metalloprotease
I0K14_RS17990	COG4589	Belongs to the CDS family
I0K14_RS18005	COG0528	UMP kinase activity
I0K14_RS18035	COG4974	Belongs to the 'phage' integrase family
I0K14_RS18045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K14_RS18050	COG0758	DNA mediated transformation
I0K14_RS18055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0K14_RS18095	COG1837	Belongs to the UPF0109 family
I0K14_RS18105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0K14_RS18115	COG0552	protein localization to endoplasmic reticulum
I0K14_RS18120	COG1196	nuclear chromosome segregation
I0K14_RS18130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K14_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS18140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I0K14_RS18155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0K14_RS18160	COG1461	Dihydroxyacetone kinase
I0K14_RS18165	COG1302	Protein conserved in bacteria
I0K14_RS18180	COG1564	THIamine pyrophosphokinase
I0K14_RS18185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I0K14_RS18195	COG0515	serine threonine protein kinase
I0K14_RS18195	COG2815	serine threonine protein kinase
I0K14_RS18200	COG0631	protein serine/threonine phosphatase activity
I0K14_RS18210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I0K14_RS18210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0K14_RS18220	COG0242	peptide deformylase activity
I0K14_RS18225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I0K14_RS18230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K14_RS18250	COG1561	YicC-like family, N-terminal region
I0K14_RS18255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I0K14_RS18270	COG0006	proline dipeptidase activity
I0K14_RS18290	COG3069	C4-dicarboxylate transmembrane transporter activity
I0K14_RS18350	COG0564	pseudouridine synthase activity
I0K14_RS18375	COG2302	S4 RNA-binding domain
I0K14_RS18380	COG0762	integral membrane protein
I0K14_RS18390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I0K14_RS18400	COG1873	PFAM PRC-barrel domain
I0K14_RS18405	COG1191	sigma factor activity
I0K14_RS18410	COG1191	sigma factor activity
I0K14_RS18420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0K14_RS18425	COG0849	cell division
I0K14_RS18430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0K14_RS18445	COG0772	Belongs to the SEDS family
I0K14_RS18460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I0K14_RS18465	COG0768	penicillin binding
I0K14_RS18470	COG0768	penicillin binding
I0K14_RS18475	COG4839	cell division protein FtsL
I0K14_RS18490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K14_RS18505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0K14_RS18510	COG1399	metal-binding, possibly nucleic acid-binding protein
I0K14_RS18520	COG3480	Lon protease (S16) C-terminal proteolytic domain
I0K14_RS18525	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K14_RS18530	COG3314	Sporulation integral membrane protein YlbJ
I0K14_RS18540	COG0742	ribosomal rna small subunit methyltransferase
I0K14_RS18555	COG3679	Belongs to the UPF0342 family
I0K14_RS18560	COG0406	alpha-ribazole phosphatase activity
I0K14_RS18575	COG2340	Cysteine-rich secretory protein family
I0K14_RS18590	COG3336	cytochrome c oxidase
I0K14_RS18625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I0K14_RS18630	COG0772	Belongs to the SEDS family
I0K14_RS18640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I0K14_RS18645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I0K14_RS18655	COG4896	Protein conserved in bacteria
I0K14_RS18670	COG1217	gtp-binding protein TYPA
I0K14_RS18680	COG0483	inositol monophosphate 1-phosphatase activity
I0K14_RS18700	COG1982	Orn Lys Arg decarboxylase major
I0K14_RS18750	COG0022	dehydrogenase e1 component
I0K14_RS18755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_RS18765	COG0242	peptide deformylase activity
I0K14_RS18770	COG0561	phosphatase activity
I0K14_RS18780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_RS18785	COG0569	domain protein
I0K14_RS18805	COG0583	DNA-binding transcription factor activity
I0K14_RS18810	COG0517	IMP dehydrogenase activity
I0K14_RS18820	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I0K14_RS18830	COG4703	Protein of unknown function (DUF1797)
I0K14_RS18845	COG2200	EAL domain
I0K14_RS18850	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS18855	COG1408	metallophosphoesterase
I0K14_RS18865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I0K14_RS18900	COG2814	Major facilitator Superfamily
I0K14_RS18925	COG3209	COG3209 Rhs family protein
I0K14_RS18935	COG2205	protein histidine kinase activity
I0K14_RS18945	COG0436	Aminotransferase
I0K14_RS18950	COG1609	Transcriptional regulator
I0K14_RS18955	COG3833	ABC-type maltose transport systems, permease component
I0K14_RS18960	COG1175	transmembrane transport
I0K14_RS18965	COG2182	Extracellular solute-binding protein
I0K14_RS18975	COG0366	Alpha amylase catalytic
I0K14_RS18980	COG3842	ATPase activity
I0K14_RS19020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0K14_RS19025	COG0183	Belongs to the thiolase family
I0K14_RS19060	COG1695	Transcriptional regulator
I0K14_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS19085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0K14_RS19090	COG0436	Aminotransferase
I0K14_RS19125	COG2084	Dehydrogenase
I0K14_RS19135	COG2199	diguanylate cyclase activity
I0K14_RS19140	COG0778	Nitroreductase
I0K14_RS19165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_RS19165	COG1263	PTS System
I0K14_RS19165	COG2190	(PTS) system
I0K14_RS19170	COG3711	transcriptional antiterminator
I0K14_RS19180	COG2188	Transcriptional regulator
I0K14_RS19190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0K14_RS19215	COG1547	Domain of unknown function (DUF309)
I0K14_RS19220	COG0456	acetyltransferase
I0K14_RS19225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0K14_RS19230	COG4086	secreted protein
I0K14_RS19235	COG0561	phosphatase activity
I0K14_RS19240	COG0697	spore germination
I0K14_RS19255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_RS19280	COG0733	neurotransmitter:sodium symporter activity
I0K14_RS19300	COG1686	Belongs to the peptidase S11 family
I0K14_RS19305	COG1725	Transcriptional regulator
I0K14_RS19310	COG1131	(ABC) transporter
I0K14_RS19330	COG1846	Transcriptional regulator
I0K14_RS19345	COG0598	Magnesium transport protein CorA
I0K14_RS19370	COG4974	Belongs to the 'phage' integrase family
I0K14_RS19380	COG0735	belongs to the Fur family
I0K14_RS19385	COG1300	Membrane
I0K14_RS19405	COG0667	Aldo Keto reductase
I0K14_RS19410	COG0656	L-ascorbic acid biosynthetic process
I0K14_RS19415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_RS19415	COG0456	acetyltransferase
I0K14_RS19425	COG4085	toxin activity
I0K14_RS19425	COG1525	nuclease
I0K14_RS19425	COG0737	Belongs to the 5'-nucleotidase family
I0K14_RS19435	COG0596	Alpha beta hydrolase
I0K14_RS19440	COG2056	Na+-H+ antiporter family
I0K14_RS19445	COG1609	Transcriptional regulator
I0K14_RS19450	COG0456	acetyltransferase
I0K14_RS19455	COG1073	alpha beta
I0K14_RS19470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K14_RS19470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K14_RS19475	COG0307	riboflavin synthase, alpha
I0K14_RS19500	COG4106	trans-aconitate 2-methyltransferase activity
I0K14_RS19505	COG2226	methyltransferase
I0K14_RS19505	COG1073	alpha beta
I0K14_RS19520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_RS19530	COG1757	Na H antiporter
I0K14_RS19535	COG0737	Belongs to the 5'-nucleotidase family
I0K14_RS19545	COG1522	sequence-specific DNA binding
I0K14_RS19580	COG5444	nuclease activity
I0K14_RS19590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0K14_RS19615	COG0300	oxidoreductase activity
I0K14_RS19620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS19625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_RS19630	COG1760	l-serine dehydratase
I0K14_RS19635	COG1760	l-serine dehydratase
I0K14_RS19660	COG1285	pathogenesis
I0K14_RS19675	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K14_RS19680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS19695	COG1376	ErfK ybiS ycfS ynhG family protein
I0K14_RS19700	COG4129	membrane
I0K14_RS19705	COG1126	abc transporter atp-binding protein
I0K14_RS19710	COG0765	amino acid transport
I0K14_RS19715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_RS19730	COG2323	membrane
I0K14_RS19735	COG0772	Belongs to the SEDS family
I0K14_RS19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_RS19745	COG0022	dehydrogenase e1 component
I0K14_RS19750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_RS19755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K14_RS19770	COG0280	phosphate acetyltransferase
I0K14_RS19775	COG3290	protein histidine kinase activity
I0K14_RS19775	COG3829	transcription factor binding
I0K14_RS19785	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_RS19790	COG3093	addiction module antidote protein HigA
I0K14_RS19795	COG0745	RESPONSE REGULATOR receiver
I0K14_RS19800	COG0750	zinc metalloprotease
I0K14_RS19805	COG0497	DNA recombination
I0K14_RS19815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I0K14_RS19825	COG0142	geranyltranstransferase activity
I0K14_RS19850	COG1302	Protein conserved in bacteria
I0K14_RS19855	COG0439	Biotin carboxylase
I0K14_RS19860	COG0511	ligase activity, forming carbon-carbon bonds
I0K14_RS19905	COG3854	ATPases associated with a variety of cellular activities
I0K14_RS19930	COG0006	proline dipeptidase activity
I0K14_RS19945	COG3872	metal-dependent enzyme
I0K14_RS19955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0K14_RS19975	COG0095	Lipoate-protein ligase
I0K14_RS19980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_RS19985	COG1609	Transcriptional regulator
I0K14_RS19995	COG2076	Multidrug Resistance protein
I0K14_RS20000	COG2076	Multidrug Resistance protein
I0K14_RS20035	COG1131	(ABC) transporter
I0K14_RS20040	COG1725	Transcriptional regulator
I0K14_RS20070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_RS20125	COG4970	Tfp pilus assembly protein FimT
I0K14_RS20135	COG1459	type II secretion system
I0K14_RS20140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I0K14_RS20190	COG0646	methionine synthase
I0K14_RS20190	COG1410	methionine synthase
I0K14_RS20195	COG0646	methionine synthase
I0K14_RS20195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I0K14_RS20200	COG0626	cystathionine gamma-synthase activity
I0K14_RS20205	COG0626	cystathionine gamma-synthase activity
I0K14_RS20225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS20235	COG1940	carbohydrate kinase activity
I0K14_RS20240	COG4483	Protein conserved in bacteria
I0K14_RS20245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0K14_RS20250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0K14_RS20255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0K14_RS20260	COG0704	Plays a role in the regulation of phosphate uptake
I0K14_RS20270	COG0581	inorganic phosphate transmembrane transporter activity
I0K14_RS20275	COG0573	inorganic phosphate transmembrane transporter activity
I0K14_RS20280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K14_RS20285	COG0768	penicillin binding
I0K14_RS20290	COG0477	Major facilitator Superfamily
I0K14_RS20295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_RS20320	COG0735	belongs to the Fur family
I0K14_RS20325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0K14_RS20330	COG1121	(ABC) transporter
I0K14_RS20335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS20365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0K14_RS20370	COG2384	SAM-dependent methyltransferase
I0K14_RS20380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0K14_RS20385	COG0358	DNA primase activity
I0K14_RS20395	COG0517	IMP dehydrogenase activity
I0K14_RS20410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0K14_RS20415	COG0295	cytidine deaminase activity
I0K14_RS20420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I0K14_RS20430	COG1480	7TM receptor with intracellular HD hydrolase
I0K14_RS20435	COG1702	phosphate starvation-inducible protein PhoH
I0K14_RS20450	COG1610	YqeY-like protein
I0K14_RS20455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0K14_RS20460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0K14_RS20465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0K14_RS20495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K14_RS20500	COG1733	regulation of RNA biosynthetic process
I0K14_RS20525	COG1466	dna polymerase III delta subunit
I0K14_RS20535	COG0658	competence protein
I0K14_RS20535	COG2333	competence protein COMEC
I0K14_RS20540	COG2131	deaminase
I0K14_RS20545	COG1596	polysaccharide export
I0K14_RS20545	COG1555	photosystem II stabilization
I0K14_RS20550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_RS20555	COG2226	methyltransferase
I0K14_RS20560	COG0799	negative regulation of ribosome biogenesis
I0K14_RS20565	COG1713	HD superfamily hydrolase involved in NAD metabolism
I0K14_RS20575	COG1534	Rna-binding protein
I0K14_RS20585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I0K14_RS20590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I0K14_RS20625	COG0778	Nitroreductase
I0K14_RS20630	COG2357	RelA SpoT domain protein
I0K14_RS20640	COG1785	Belongs to the alkaline phosphatase family
I0K14_RS20650	COG2267	carboxylic ester hydrolase activity
I0K14_RS20685	COG1404	Belongs to the peptidase S8 family
I0K14_RS20690	COG3186	Phenylalanine-4-hydroxylase
I0K14_RS20700	COG2514	catechol 2,3-dioxygenase activity
I0K14_RS20705	COG2259	Doxx family
I0K14_RS20745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I0K14_RS20755	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_RS20755	COG1454	alcohol dehydrogenase
I0K14_RS20760	COG0626	cystathionine gamma-synthase activity
I0K14_RS20765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_RS20790	COG0768	penicillin binding
I0K14_RS20805	COG0826	peptidase U32
I0K14_RS20810	COG0826	peptidase U32
I0K14_RS20815	COG4122	O-methyltransferase activity
I0K14_RS20820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0K14_RS20850	COG0628	permease
I0K14_RS20870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0K14_RS20885	COG1104	cysteine desulfurase activity
I0K14_RS20890	COG1959	2 iron, 2 sulfur cluster binding
I0K14_RS20895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0K14_RS20905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I0K14_RS20935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0K14_RS20945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I0K14_RS20945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0K14_RS20950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K14_RS20955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K14_RS20955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K14_RS20965	COG2244	polysaccharide biosynthetic process
I0K14_RS20970	COG2323	membrane
I0K14_RS20980	COG1862	Preprotein translocase
I0K14_RS21010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I0K14_RS21020	COG0697	spore germination
I0K14_RS21025	COG0640	Transcriptional regulator
I0K14_RS21050	COG0157	Belongs to the NadC ModD family
I0K14_RS21055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I0K14_RS21060	COG1104	cysteine desulfurase activity
I0K14_RS21065	COG1827	regulation of RNA biosynthetic process
I0K14_RS21070	COG2258	MOSC domain
I0K14_RS21075	COG0077	Prephenate dehydratase
I0K14_RS21080	COG0577	efflux transmembrane transporter activity
I0K14_RS21085	COG0577	efflux transmembrane transporter activity
I0K14_RS21090	COG1136	(ABC) transporter
I0K14_RS21095	COG5002	protein histidine kinase activity
I0K14_RS21100	COG0745	RESPONSE REGULATOR receiver
I0K14_RS21110	COG3290	protein histidine kinase activity
I0K14_RS21120	COG2868	ribosomal protein
I0K14_RS21125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0K14_RS21130	COG1530	ribonuclease E activity
I0K14_RS21135	COG1994	Peptidase M50
I0K14_RS21140	COG0739	heme binding
I0K14_RS21145	COG2894	cell division
I0K14_RS21165	COG1077	Cell shape determining protein MreB Mrl
I0K14_RS21185	COG0285	dihydrofolate synthase activity
I0K14_RS21200	COG1388	LysM domain
I0K14_RS21210	COG0113	porphobilinogen synthase activity
I0K14_RS21215	COG1587	Uroporphyrinogen-III synthase
I0K14_RS21225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K14_RS21235	COG1846	Transcriptional regulator
I0K14_RS21240	COG1764	response to oxidative stress
I0K14_RS21255	COG0470	DNA polymerase III
I0K14_RS21255	COG1067	ATP-dependent peptidase activity
I0K14_RS21300	COG0622	Phosphoesterase
I0K14_RS21315	COG5401	PFAM Sporulation and spore germination
I0K14_RS21325	COG2814	Major facilitator Superfamily
I0K14_RS21335	COG1309	transcriptional regulator
I0K14_RS21345	COG2197	response regulator
I0K14_RS21360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I0K14_RS21360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0K14_RS21370	COG0497	DNA recombination
I0K14_RS21425	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I0K14_RS21445	COG2197	response regulator
I0K14_RS21450	COG2233	PERMEase
I0K14_RS21460	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_RS21465	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_RS21475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_RS21485	COG0444	Belongs to the ABC transporter superfamily
I0K14_RS21490	COG4608	Belongs to the ABC transporter superfamily
I0K14_RS21495	COG3275	phosphorelay sensor kinase activity
I0K14_RS21500	COG3279	Response regulator of the LytR AlgR family
I0K14_RS21510	COG1983	PspC domain protein
I0K14_RS21515	COG1396	sequence-specific DNA binding
I0K14_RS21520	COG0697	spore germination
I0K14_RS21530	COG1959	2 iron, 2 sulfur cluster binding
I0K14_RS21535	COG1668	transmembrane transport
I0K14_RS21540	COG4152	abc transporter atp-binding protein
I0K14_RS21545	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I0K14_RS21550	COG1360	Flagellar Motor Protein
I0K14_RS21555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K14_RS21560	COG1876	peptidase activity
I0K14_RS21565	COG0824	Thioesterase
I0K14_RS21570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I0K14_RS21575	COG1053	succinate dehydrogenase
I0K14_RS21580	COG2009	succinate dehydrogenase
I0K14_RS21585	COG1719	4-vinyl reductase, 4VR
I0K14_RS21595	COG3118	belongs to the thioredoxin family
I0K14_RS21600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0K14_RS21605	COG2086	electron transfer activity
I0K14_RS21610	COG1024	Enoyl-CoA hydratase
I0K14_RS21615	COG1309	transcriptional regulator
I0K14_RS21620	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_RS21630	COG2318	DinB family
I0K14_RS21655	COG1131	(ABC) transporter
I0K14_RS21660	COG2205	protein histidine kinase activity
I0K14_RS21665	COG0745	RESPONSE REGULATOR receiver
I0K14_RS21675	COG4895	conserved protein (DUF2196)
I0K14_RS21680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I0K14_RS21695	COG4509	Sortase family
I0K14_RS21700	COG1120	ATPase activity
I0K14_RS21715	COG5386	Cell surface protein
I0K14_RS21720	COG5386	Cell surface protein
I0K14_RS21725	COG1114	Component of the transport system for branched-chain amino acids
I0K14_RS21730	COG1187	pseudouridine synthase activity
I0K14_RS21740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I0K14_RS21740	COG1796	DNA polymerase
I0K14_RS21745	COG1286	toxin biosynthetic process
I0K14_RS21790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K14_RS21800	COG1418	mRNA catabolic process
I0K14_RS21835	COG2814	Major facilitator Superfamily
I0K14_RS21840	COG1566	PFAM secretion protein HlyD family protein
I0K14_RS21845	COG1309	transcriptional regulator
I0K14_RS21850	COG1363	Peptidase, m42
I0K14_RS21875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K14_RS21885	COG1484	DNA-dependent DNA replication
I0K14_RS21890	COG3611	Membrane attachment protein
I0K14_RS21900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I0K14_RS21905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K14_RS21910	COG0237	dephospho-CoA kinase activity
I0K14_RS21915	COG1971	Probably functions as a manganese efflux pump
I0K14_RS21925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_RS21925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_RS21930	COG5002	protein histidine kinase activity
I0K14_RS21935	COG0745	RESPONSE REGULATOR receiver
I0K14_RS21950	COG0538	isocitrate dehydrogenase activity
I0K14_RS21955	COG0372	Belongs to the citrate synthase family
I0K14_RS21965	COG0628	permease
I0K14_RS21970	COG3030	protein affecting phage T7 exclusion by the F plasmid
I0K14_RS21995	COG1725	Transcriptional regulator
I0K14_RS22000	COG0281	malic enzyme
I0K14_RS22005	COG0587	DNA-directed DNA polymerase activity
I0K14_RS22020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I0K14_RS22035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_RS22045	COG4109	DRTGG domain
I0K14_RS22060	COG0006	proline dipeptidase activity
I0K14_RS22090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS22095	COG0662	Cupin 2, conserved barrel domain protein
I0K14_RS22140	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_RS22145	COG0589	response to stress
I0K14_RS22190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS22215	COG0827	DNA restriction-modification system
I0K14_RS22220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I0K14_RS22225	COG3874	Sporulation protein YtfJ
I0K14_RS22240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I0K14_RS22250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_RS22265	COG1104	cysteine desulfurase activity
I0K14_RS22275	COG0583	DNA-binding transcription factor activity
I0K14_RS22280	COG0697	spore germination
I0K14_RS22285	COG1309	transcriptional regulator
I0K14_RS22290	COG1956	GAF domain-containing protein
I0K14_RS22295	COG0626	cystathionine gamma-synthase activity
I0K14_RS22325	COG1595	DNA-templated transcription, initiation
I0K14_RS22340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_RS22345	COG0454	-acetyltransferase
I0K14_RS22350	COG0517	IMP dehydrogenase activity
I0K14_RS22355	COG0123	including yeast histone deacetylase and acetoin utilization protein
I0K14_RS22370	COG0745	RESPONSE REGULATOR receiver
I0K14_RS22380	COG0666	response to abiotic stimulus
I0K14_RS22420	COG1609	Transcriptional regulator
I0K14_RS22425	COG4851	CamS sex pheromone cAM373 precursor
I0K14_RS22430	COG3118	belongs to the thioredoxin family
I0K14_RS22440	COG2309	aminopeptidase activity
I0K14_RS22460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS22465	COG0697	spore germination
I0K14_RS22470	COG0789	Transcriptional regulator
I0K14_RS22475	COG1695	Transcriptional regulator
I0K14_RS22495	COG1674	ftsk spoiiie
I0K14_RS22505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_RS22515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_RS22520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I0K14_RS22525	COG1363	Peptidase, m42
I0K14_RS22535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS22550	COG0510	thiamine kinase activity
I0K14_RS22555	COG1523	belongs to the glycosyl hydrolase 13 family
I0K14_RS22565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_RS22570	COG1349	DNA-binding transcription factor activity
I0K14_RS22575	COG1187	pseudouridine synthase activity
I0K14_RS22580	COG2244	polysaccharide biosynthetic process
I0K14_RS22585	COG2081	HI0933 family
I0K14_RS22590	COG2814	Major facilitator Superfamily
I0K14_RS22600	COG3832	glyoxalase III activity
I0K14_RS22620	COG1329	Transcriptional regulator
I0K14_RS22645	COG0314	molybdopterin synthase activity
I0K14_RS22650	COG1763	Mo-molybdopterin cofactor biosynthetic process
I0K14_RS22655	COG0303	'Molybdopterin
I0K14_RS22665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_RS22670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K14_RS22690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_RS22700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0K14_RS22740	COG2814	Major facilitator Superfamily
I0K14_RS22745	COG0475	glutathione-regulated potassium exporter activity
I0K14_RS22750	COG0490	domain, Protein
I0K14_RS22755	COG0582	viral genome integration into host DNA
I0K14_RS22765	COG1136	(ABC) transporter
I0K14_RS22785	COG1242	4 iron, 4 sulfur cluster binding
I0K14_RS22790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I0K14_RS22805	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_RS22830	COG2267	carboxylic ester hydrolase activity
I0K14_RS22835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I0K14_RS22840	COG0671	phosphoesterase, PA-phosphatase related
I0K14_RS22845	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS22855	COG0521	Mo-molybdopterin cofactor biosynthetic process
I0K14_RS22900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0K14_RS22905	COG0546	phosphoglycolate phosphatase activity
I0K14_RS22910	COG1349	DNA-binding transcription factor activity
I0K14_RS22920	COG5002	protein histidine kinase activity
I0K14_RS22925	COG4191	Histidine kinase
I0K14_RS22930	COG2267	carboxylic ester hydrolase activity
I0K14_RS22935	COG1368	sulfuric ester hydrolase activity
I0K14_RS22955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_RS22960	COG1116	anion transmembrane transporter activity
I0K14_RS22965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_RS22990	COG0494	nUDIX hydrolase
I0K14_RS23020	COG0288	reversible hydration of carbon dioxide
I0K14_RS23025	COG1271	oxidase subunit
I0K14_RS23030	COG1294	oxidase, subunit
I0K14_RS23050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS23075	COG1842	Phage shock protein A
I0K14_RS23110	COG5002	protein histidine kinase activity
I0K14_RS23115	COG0745	RESPONSE REGULATOR receiver
I0K14_RS23145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K14_RS23150	COG1597	lipid kinase activity
I0K14_RS23165	COG0577	efflux transmembrane transporter activity
I0K14_RS23170	COG1136	(ABC) transporter
I0K14_RS23195	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS23205	COG4977	sequence-specific DNA binding
I0K14_RS23215	COG0577	efflux transmembrane transporter activity
I0K14_RS23220	COG1136	(ABC) transporter
I0K14_RS23225	COG3708	Transcriptional regulator
I0K14_RS23225	COG2207	Transcriptional regulator
I0K14_RS23230	COG5658	integral membrane protein
I0K14_RS23235	COG0640	Transcriptional regulator
I0K14_RS23240	COG0745	RESPONSE REGULATOR receiver
I0K14_RS23245	COG2205	protein histidine kinase activity
I0K14_RS23250	COG0577	efflux transmembrane transporter activity
I0K14_RS23255	COG0577	efflux transmembrane transporter activity
I0K14_RS23260	COG1136	(ABC) transporter
I0K14_RS23265	COG0577	efflux transmembrane transporter activity
I0K14_RS23290	COG2188	Transcriptional regulator
I0K14_RS23310	COG3964	amidohydrolase
I0K14_RS23330	COG4948	Mandelate Racemase Muconate Lactonizing
I0K14_RS23340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I0K14_RS23345	COG0596	Alpha beta hydrolase
I0K14_RS23355	COG1169	isochorismate synthase
I0K14_RS23360	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K14_RS23365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I0K14_RS23385	COG0058	SHG alpha-glucan phosphorylase activity
I0K14_RS23395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I0K14_RS23415	COG1404	Belongs to the peptidase S8 family
I0K14_RS23515	COG0544	peptidyl-prolyl cis-trans isomerase activity
I0K14_RS23550	COG1285	pathogenesis
I0K14_RS23555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K14_RS23570	COG2155	Conserved Protein
I0K14_RS23575	COG1098	S1 RNA binding domain
I0K14_RS23580	COG0436	Aminotransferase
I0K14_RS23585	COG1522	sequence-specific DNA binding
I0K14_RS23590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K14_RS23595	COG2267	carboxylic ester hydrolase activity
I0K14_RS23605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I0K14_RS23625	COG5018	Exonuclease
I0K14_RS23630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_RS23650	COG2050	protein possibly involved in aromatic compounds catabolism
I0K14_RS23660	COG1268	BioY protein
I0K14_RS23665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K14_RS23670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0K14_RS23685	COG3584	3D domain protein
I0K14_RS23700	COG1252	NADH dehydrogenase
I0K14_RS23710	COG3708	Transcriptional regulator
I0K14_RS23725	COG1683	Conserved Protein
I0K14_RS23740	COG0316	Belongs to the HesB IscA family
I0K14_RS23755	COG1252	NADH dehydrogenase
I0K14_RS23765	COG2274	protein secretion by the type I secretion system
I0K14_RS23770	COG0390	transport system, permease component
I0K14_RS23775	COG2824	Alkylphosphonate utilization operon protein PhnA
I0K14_RS23815	COG4837	Protein of unknown function (DUF1462)
I0K14_RS23820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I0K14_RS23830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_RS23835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I0K14_RS23845	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_RS23855	COG0647	UMP catabolic process
I0K14_RS23865	COG2445	Protein of unknown function DUF86
I0K14_RS23870	COG1494	fructose-1,6-bisphosphatase
I0K14_RS23885	COG4470	Protein conserved in bacteria
I0K14_RS23895	COG0789	Transcriptional regulator
I0K14_RS23900	COG4377	Putative membrane peptidase family (DUF2324)
I0K14_RS23925	COG0739	heme binding
I0K14_RS23935	COG3377	Domain of unknown function (DUF1805)
I0K14_RS23940	COG0737	Belongs to the 5'-nucleotidase family
I0K14_RS23945	COG0719	Fe-S assembly protein
I0K14_RS23950	COG0822	iron-sulfur transferase activity
I0K14_RS23955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0K14_RS23960	COG0719	Fe-S assembly protein
I0K14_RS23965	COG0396	ATPase activity
I0K14_RS23970	COG1464	Belongs to the NlpA lipoprotein family
I0K14_RS23975	COG1464	Belongs to the NlpA lipoprotein family
I0K14_RS23980	COG2011	ABC-type metal ion transport system permease component
I0K14_RS23995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_RS24000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I0K14_RS24010	COG1393	Belongs to the ArsC family
I0K14_RS24055	COG1309	transcriptional regulator
I0K14_RS24060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_RS24065	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS24070	COG0183	Belongs to the thiolase family
I0K14_RS24075	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K14_RS24075	COG1024	Enoyl-CoA hydratase
I0K14_RS24085	COG1686	Belongs to the peptidase S11 family
I0K14_RS24115	COG0011	TIGRFAM Protein of
I0K14_RS24120	COG0840	transmembrane signaling receptor activity
I0K14_RS24145	COG2814	Major facilitator Superfamily
I0K14_RS24150	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I0K14_RS24160	COG0531	amino acid
I0K14_RS24185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_RS24220	COG0586	Pfam SNARE associated Golgi protein
I0K14_RS24230	COG1376	ErfK ybiS ycfS ynhG family protein
I0K14_RS24235	COG0745	RESPONSE REGULATOR receiver
I0K14_RS24240	COG5002	protein histidine kinase activity
I0K14_RS24265	COG0840	transmembrane signaling receptor activity
I0K14_RS24270	COG2151	metal-sulfur cluster biosynthetic enzyme
I0K14_RS24275	COG3227	Zinc metalloprotease (Elastase)
I0K14_RS24280	COG1741	Belongs to the pirin family
I0K14_RS24295	COG0475	glutathione-regulated potassium exporter activity
I0K14_RS24300	COG0490	domain, Protein
I0K14_RS24305	COG1115	amino acid carrier protein
I0K14_RS24310	COG0783	Belongs to the Dps family
I0K14_RS24325	COG1611	Belongs to the LOG family
I0K14_RS24345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS24350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS24355	COG1115	amino acid carrier protein
I0K14_RS24360	COG1115	amino acid carrier protein
I0K14_RS24365	COG2910	NAD(P)H-binding
I0K14_RS24380	COG0656	L-ascorbic acid biosynthetic process
I0K14_RS24385	COG2814	Major facilitator Superfamily
I0K14_RS24390	COG1733	regulation of RNA biosynthetic process
I0K14_RS24400	COG1252	NADH dehydrogenase
I0K14_RS24405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I0K14_RS24420	COG3290	protein histidine kinase activity
I0K14_RS24420	COG0840	transmembrane signaling receptor activity
I0K14_RS24430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0K14_RS24445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_RS24490	COG5002	protein histidine kinase activity
I0K14_RS24495	COG0745	RESPONSE REGULATOR receiver
I0K14_RS24500	COG1136	(ABC) transporter
I0K14_RS24520	COG1136	(ABC) transporter
I0K14_RS24555	COG0557	exoribonuclease II activity
I0K14_RS24560	COG1647	Serine aminopeptidase, S33
I0K14_RS24565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K14_RS24570	COG1346	cytolysis
I0K14_RS24605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K14_RS24620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I0K14_RS24645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_RS24660	COG2323	membrane
I0K14_RS24670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_RS24680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I0K14_RS24690	COG1051	belongs to the nudix hydrolase family
I0K14_RS24700	COG0492	ferredoxin-NADP+ reductase activity
I0K14_RS24705	COG0457	Tetratricopeptide repeat
I0K14_RS24710	COG0110	maltose O-acetyltransferase activity
I0K14_RS24730	COG1950	PFAM Membrane protein of
I0K14_RS24740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0K14_RS24755	COG0789	Transcriptional regulator
I0K14_RS24785	COG0583	DNA-binding transcription factor activity
I0K14_RS24795	COG0655	NAD(P)H dehydrogenase (quinone) activity
I0K14_RS24800	COG0488	(ABC) transporter
I0K14_RS24810	COG1132	(ABC) transporter
I0K14_RS24815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_RS24820	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_RS24820	COG0793	Belongs to the peptidase S41A family
I0K14_RS24825	COG2177	Part of the ABC transporter FtsEX involved in
I0K14_RS24830	COG2884	Cell division ATP-binding protein ftsE
I0K14_RS24850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0K14_RS24855	COG1278	Cold shock
I0K14_RS24860	COG1040	competence protein
I0K14_RS24865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I0K14_RS24870	COG0791	NLP P60 protein
I0K14_RS24875	COG1733	regulation of RNA biosynthetic process
I0K14_RS24880	COG1307	EDD domain protein, DegV family
I0K14_RS24885	COG1739	Uncharacterized protein family UPF0029
I0K14_RS24890	COG1316	TRANSCRIPTIONal
I0K14_RS24895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I0K14_RS24900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0K14_RS24905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0K14_RS24915	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I0K14_RS24915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I0K14_RS24935	COG1486	melibiose metabolic process
I0K14_RS24940	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_RS24945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_RS24965	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_RS24975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_RS24980	COG1301	dicarboxylic acid transport
I0K14_RS24990	COG0346	lactoylglutathione lyase activity
I0K14_RS24995	COG1511	domain protein
I0K14_RS25000	COG0583	DNA-binding transcription factor activity
I0K14_RS25005	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I0K14_RS25015	COG1271	oxidase subunit
I0K14_RS25020	COG1294	oxidase, subunit
I0K14_RS25025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_RS25035	COG1620	l-lactate permease
I0K14_RS25045	COG2389	metal-binding protein
I0K14_RS25055	COG1368	sulfuric ester hydrolase activity
I0K14_RS25065	COG1388	LysM domain
I0K14_RS25065	COG0791	NLP P60 protein
I0K14_RS25070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_RS25080	COG1215	transferase activity, transferring glycosyl groups
I0K14_RS25085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_RS25090	COG1388	LysM domain
I0K14_RS25090	COG3584	3D domain protein
I0K14_RS25115	COG4715	Zinc finger, swim domain protein
I0K14_RS25120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_RS25165	COG0577	efflux transmembrane transporter activity
I0K14_RS25170	COG1136	(ABC) transporter
I0K14_RS25195	COG3850	Histidine kinase
I0K14_RS25195	COG5002	protein histidine kinase activity
I0K14_RS25200	COG0745	RESPONSE REGULATOR receiver
I0K14_RS25205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K14_RS25215	COG1316	TRANSCRIPTIONal
I0K14_RS25225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0K14_RS25250	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS25260	COG1215	transferase activity, transferring glycosyl groups
I0K14_RS25265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K14_RS25270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0K14_RS25275	COG1086	Polysaccharide biosynthesis protein
I0K14_RS25280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K14_RS25285	COG4464	protein tyrosine phosphatase activity
I0K14_RS25290	COG0489	protein tyrosine kinase activity
I0K14_RS25295	COG3944	biosynthesis protein
I0K14_RS25300	COG0489	protein tyrosine kinase activity
I0K14_RS25315	COG1609	Transcriptional regulator
I0K14_RS25325	COG0739	heme binding
I0K14_RS25340	COG3279	Response regulator of the LytR AlgR family
I0K14_RS25345	COG2385	sporulation resulting in formation of a cellular spore
I0K14_RS25360	COG4836	Membrane
I0K14_RS25365	COG1007	ATP synthesis coupled electron transport
I0K14_RS25370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K14_RS25375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K14_RS25385	COG0839	Belongs to the complex I subunit 6 family
I0K14_RS25405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K14_RS25420	COG5001	Diguanylate cyclase
I0K14_RS25420	COG3300	MHYT domain
I0K14_RS25470	COG0356	it plays a direct role in the translocation of protons across the membrane
I0K14_RS25505	COG0698	ribose 5-phosphate isomerase
I0K14_RS25515	COG2190	(PTS) system
I0K14_RS25520	COG2259	Doxx family
I0K14_RS25525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K14_RS25545	COG0009	L-threonylcarbamoyladenylate synthase
I0K14_RS25560	COG2890	protein-(glutamine-N5) methyltransferase activity
I0K14_RS25580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I0K14_RS25585	COG1494	fructose-1,6-bisphosphatase
I0K14_RS25605	COG4821	SIS domain
I0K14_RS25625	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS25630	COG1960	acyl-CoA dehydrogenase activity
I0K14_RS25635	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K14_RS25640	COG0183	Belongs to the thiolase family
I0K14_RS25645	COG0247	lactate metabolic process
I0K14_RS25645	COG2181	nitrate reductase activity
I0K14_RS25650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_RS25660	COG3300	MHYT domain
I0K14_RS25660	COG5001	Diguanylate cyclase
I0K14_RS25680	COG2197	response regulator
I0K14_RS25685	COG4585	Histidine kinase
I0K14_RS25690	COG0842	Transport permease protein
I0K14_RS25695	COG1131	(ABC) transporter
I0K14_RS25700	COG0024	Methionine aminopeptidase
I0K14_RS25710	COG2234	aminopeptidase activity
I0K14_RS25730	COG4506	Protein conserved in bacteria
I0K14_RS25735	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_RS25760	COG2814	Major facilitator Superfamily
I0K14_RS25765	COG0789	Transcriptional regulator
I0K14_RS25770	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_RS25775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_RS25785	COG1994	Peptidase M50
I0K14_RS25795	COG1078	dGTPase activity
I0K14_RS25800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_RS25805	COG1120	ATPase activity
I0K14_RS25810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS25815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_RS25835	COG0095	Lipoate-protein ligase
I0K14_RS25840	COG0280	phosphate acetyltransferase
I0K14_RS25855	COG3773	Cell wall hydrolase
I0K14_RS25865	COG2363	Small membrane protein
I0K14_RS25875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K14_RS25880	COG2233	PERMEase
I0K14_RS25885	COG0561	phosphatase activity
I0K14_RS25890	COG2814	Major facilitator Superfamily
I0K14_RS25900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_RS25905	COG1131	(ABC) transporter
I0K14_RS25910	COG2755	lipolytic protein G-D-S-L family
I0K14_RS25915	COG1609	Transcriptional regulator
I0K14_RS25925	COG0460	homoserine dehydrogenase
I0K14_RS25935	COG2873	o-acetylhomoserine
I0K14_RS25940	COG1011	Hydrolase
I0K14_RS25945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_RS25955	COG2197	response regulator
I0K14_RS25960	COG4585	Histidine kinase
I0K14_RS25960	COG2203	Gaf domain
I0K14_RS25965	COG0351	phosphomethylpyrimidine kinase
I0K14_RS25970	COG3706	GGDEF domain
I0K14_RS25975	COG2879	small protein
I0K14_RS25980	COG1966	Carbon starvation protein
I0K14_RS25985	COG3279	Response regulator of the LytR AlgR family
I0K14_RS25990	COG0477	Major facilitator Superfamily
I0K14_RS26000	COG0438	transferase activity, transferring glycosyl groups
I0K14_RS26015	COG0840	transmembrane signaling receptor activity
I0K14_RS26025	COG1607	acyl-coa hydrolase
I0K14_RS26030	COG1216	Glycosyl transferase, family 2
I0K14_RS26045	COG1216	Glycosyl transferase, family 2
I0K14_RS26050	COG0488	(ABC) transporter
I0K14_RS26055	COG1696	Membrane protein involved in D-alanine export
I0K14_RS26065	COG1309	transcriptional regulator
I0K14_RS26070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K14_RS26075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_RS26075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_RS26085	COG0628	permease
I0K14_RS26100	COG3279	Response regulator of the LytR AlgR family
I0K14_RS26105	COG3275	phosphorelay sensor kinase activity
I0K14_RS26110	COG2814	Major facilitator Superfamily
I0K14_RS26115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_RS26120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I0K14_RS26125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_RS26170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K14_RS26175	COG1272	protein, Hemolysin III
I0K14_RS26195	COG1164	Oligoendopeptidase f
I0K14_RS26215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_RS26220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I0K14_RS26225	COG4853	Protein conserved in bacteria
I0K14_RS26230	COG4863	YycH protein
I0K14_RS26235	COG5002	protein histidine kinase activity
I0K14_RS26240	COG0745	RESPONSE REGULATOR receiver
I0K14_RS26270	COG0305	Participates in initiation and elongation during chromosome replication
I0K14_RS26280	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I0K14_RS26285	COG4241	membrane
I0K14_RS26295	COG0629	single-stranded DNA binding
I0K14_RS26305	COG0012	GTP binding
I0K14_RS26310	COG4481	Protein conserved in bacteria
I0K14_RS26315	COG0668	transmembrane transport
I0K14_RS26325	COG1475	DNA binding
I0K14_RS26330	COG1192	Involved in chromosome partitioning
I0K14_RS26355	COG1847	R3H domain protein
I0K14_RS26360	COG0706	membrane insertase activity
I0K14_RS26370	COG0230	Belongs to the bacterial ribosomal protein bL34 family