locus-tag	class	description
HWC53_gp005	COG0202	RNA polymerase activity
HWC53_gp020	COG1404	Belongs to the peptidase S8 family
HWC53_gp024	COG4195	phage-related replication protein
HWC53_gp032	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWC53_gp036	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWC53_gp041	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWC53_gp042	COG1876	peptidase activity
HWC53_gp073	COG0202	RNA polymerase activity
HWC53_gp090	COG1191	sigma factor activity
HWC53_gp127	COG0739	heme binding
HWC53_gp144	COG1690	Belongs to the RtcB family
HWC53_gp147	COG1191	sigma factor activity
HWC53_gp181	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWC53_gp188	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWC53_gp188	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWC53_gp194	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWC53_gp196	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWC53_gp201	COG0756	dUTP diphosphatase activity
HWC53_gp205	COG0420	3'-5' exonuclease activity
HWC53_gp226	COG3883	PFAM NLP P60 protein
HWC53_gp226	COG0791	NLP P60 protein
HWC53_gp232	COG3583	domain protein
HWC53_gp232	COG3584	3D domain protein