locus-tag	class	description
BW16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW16_RS00010	COG0592	DNA-directed DNA polymerase activity
BW16_RS00015	COG2501	S4 domain
BW16_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW16_RS00030	COG0187	DNA topoisomerase II activity
BW16_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW16_RS00070	COG0516	GMP reductase activity
BW16_RS00070	COG0517	IMP dehydrogenase activity
BW16_RS00075	COG1686	Belongs to the peptidase S11 family
BW16_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BW16_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BW16_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW16_RS00100	COG0840	transmembrane signaling receptor activity
BW16_RS00110	COG1428	Deoxynucleoside kinase
BW16_RS00115	COG1428	Deoxynucleoside kinase
BW16_RS00120	COG1388	LysM domain
BW16_RS00120	COG3858	chitin binding
BW16_RS00125	COG1335	isochorismatase
BW16_RS00130	COG0590	tRNA wobble adenosine to inosine editing
BW16_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW16_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW16_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BW16_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BW16_RS00195	COG3853	Toxic anion resistance protein (TelA)
BW16_RS00200	COG1982	Orn Lys Arg decarboxylase major
BW16_RS00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW16_RS00210	COG3870	Protein conserved in bacteria
BW16_RS00215	COG1728	Protein conserved in bacteria
BW16_RS00220	COG0470	DNA polymerase III
BW16_RS00225	COG1774	PSP1 C-terminal conserved region
BW16_RS00230	COG4467	Involved in initiation control of chromosome replication
BW16_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BW16_RS00240	COG2827	Endonuclease containing a URI domain
BW16_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BW16_RS00250	COG2002	toxin-antitoxin pair type II binding
BW16_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_RS00260	COG0084	hydrolase, TatD family'
BW16_RS00265	COG3583	domain protein
BW16_RS00265	COG3584	3D domain protein
BW16_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BW16_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW16_RS00285	COG4466	Protein conserved in bacteria
BW16_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW16_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_RS00305	COG0251	oxidation-reduction process
BW16_RS00310	COG2088	sporulation resulting in formation of a cellular spore
BW16_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW16_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW16_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
BW16_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BW16_RS00345	COG2002	toxin-antitoxin pair type II binding
BW16_RS00350	COG2244	polysaccharide biosynthetic process
BW16_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BW16_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BW16_RS00380	COG1098	S1 RNA binding domain
BW16_RS00395	COG2208	phosphoserine phosphatase activity
BW16_RS00400	COG2304	oxidoreductase activity
BW16_RS00405	COG0515	serine threonine protein kinase
BW16_RS00410	COG0037	tRNA processing
BW16_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BW16_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW16_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BW16_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BW16_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BW16_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW16_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
BW16_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW16_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW16_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BW16_RS00475	COG1396	sequence-specific DNA binding
BW16_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BW16_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW16_RS00565	COG4463	regulation of RNA biosynthetic process
BW16_RS00570	COG3880	PFAM UvrB UvrC protein
BW16_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BW16_RS00580	COG0542	response to heat
BW16_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW16_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW16_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
BW16_RS00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW16_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW16_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW16_RS00615	COG1045	serine acetyltransferase
BW16_RS00620	COG0215	cysteine-tRNA ligase activity
BW16_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BW16_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW16_RS00635	COG3688	RNA-binding protein containing a PIN domain
BW16_RS00640	COG1595	DNA-templated transcription, initiation
BW16_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW16_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
BW16_RS00660	COG0081	regulation of translation
BW16_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW16_RS00670	COG0222	ribosome binding
BW16_RS00675	COG2813	Specifically methylates the guanine in position
BW16_RS00680	COG0085	RNA polymerase activity
BW16_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW16_RS00690	COG1358	cellular component organization or biogenesis
BW16_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW16_RS00700	COG0049	tRNA binding
BW16_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW16_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW16_RS00715	COG0596	Alpha beta hydrolase
BW16_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW16_RS00730	COG0088	Forms part of the polypeptide exit tunnel
BW16_RS00735	COG0089	rRNA binding
BW16_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW16_RS00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW16_RS00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW16_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW16_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW16_RS00765	COG0255	Belongs to the universal ribosomal protein uL29 family
BW16_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW16_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW16_RS00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW16_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW16_RS00790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW16_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW16_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW16_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW16_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW16_RS00815	COG1841	ribosomal large subunit assembly
BW16_RS00820	COG0200	Binds to the 23S rRNA
BW16_RS00825	COG0201	protein transport
BW16_RS00830	COG0563	adenylate kinase activity
BW16_RS00835	COG0024	Methionine aminopeptidase
BW16_RS00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW16_RS00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW16_RS00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW16_RS00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW16_RS00860	COG0202	RNA polymerase activity
BW16_RS00865	COG0203	ribosomal protein L17
BW16_RS00870	COG1122	ATPase activity
BW16_RS00875	COG1122	ATPase activity
BW16_RS00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_RS00885	COG0101	tRNA pseudouridine synthase activity
BW16_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW16_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BW16_RS00900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_RS00930	COG0489	protein tyrosine kinase activity
BW16_RS00940	COG2194	sulfuric ester hydrolase activity
BW16_RS00945	COG0726	polysaccharide deacetylase
BW16_RS00975	COG0659	secondary active sulfate transmembrane transporter activity
BW16_RS00980	COG0385	Bile acid
BW16_RS00985	COG3876	Protein conserved in bacteria
BW16_RS00990	COG1472	Belongs to the glycosyl hydrolase 3 family
BW16_RS00995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BW16_RS01000	COG1263	PTS System
BW16_RS01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS01005	COG1737	Transcriptional regulator
BW16_RS01010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BW16_RS01045	COG1595	DNA-templated transcription, initiation
BW16_RS01050	COG5662	AntiSigma factor
BW16_RS01055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BW16_RS01060	COG4856	YbbR-like protein
BW16_RS01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW16_RS01070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW16_RS01085	COG1131	(ABC) transporter
BW16_RS01095	COG1136	(ABC) transporter
BW16_RS01105	COG1695	Transcriptional regulator
BW16_RS01115	COG1131	(ABC) transporter
BW16_RS01125	COG1413	lyase activity
BW16_RS01130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS01145	COG2311	Membrane
BW16_RS01165	COG1476	TRANSCRIPTIONal
BW16_RS01175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW16_RS01180	COG2207	Transcriptional regulator
BW16_RS01185	COG1309	transcriptional regulator
BW16_RS01200	COG1113	amino acid transport
BW16_RS01205	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_RS01210	COG2271	Major facilitator Superfamily
BW16_RS01220	COG1331	Highly conserved protein containing a thioredoxin domain
BW16_RS01245	COG0640	Transcriptional regulator
BW16_RS01260	COG1937	Protein conserved in bacteria
BW16_RS01265	COG2210	Belongs to the sulfur carrier protein TusA family
BW16_RS01275	COG0425	Belongs to the sulfur carrier protein TusA family
BW16_RS01275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_RS01280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_RS01280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS01285	COG0425	Belongs to the sulfur carrier protein TusA family
BW16_RS01290	COG0730	response to heat
BW16_RS01295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_RS01300	COG2814	Major facilitator Superfamily
BW16_RS01315	COG1846	Transcriptional regulator
BW16_RS01325	COG1683	Conserved Protein
BW16_RS01335	COG0656	L-ascorbic acid biosynthetic process
BW16_RS01340	COG0371	Dehydrogenase
BW16_RS01345	COG1054	Belongs to the UPF0176 family
BW16_RS01350	COG0531	amino acid
BW16_RS01360	COG3711	transcriptional antiterminator
BW16_RS01365	COG2190	(PTS) system
BW16_RS01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS01365	COG1263	PTS System
BW16_RS01370	COG2723	6-phospho-beta-galactosidase activity
BW16_RS01390	COG2801	Transposase and inactivated derivatives
BW16_RS01400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS01400	COG3711	transcriptional antiterminator
BW16_RS01405	COG1940	carbohydrate kinase activity
BW16_RS01410	COG0383	alpha-mannosidase activity
BW16_RS01415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS01420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS01430	COG1404	Belongs to the peptidase S8 family
BW16_RS01445	COG0833	amino acid
BW16_RS01450	COG2040	homocysteine
BW16_RS01455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_RS01460	COG1695	Transcriptional regulator
BW16_RS01470	COG2814	Major facilitator Superfamily
BW16_RS01475	COG0456	acetyltransferase
BW16_RS01495	COG1404	Belongs to the peptidase S8 family
BW16_RS01505	COG1309	transcriptional regulator
BW16_RS01510	COG1917	Cupin 2, conserved barrel domain protein
BW16_RS01515	COG1846	Transcriptional regulator
BW16_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS01525	COG0531	amino acid
BW16_RS01535	COG0596	Alpha beta hydrolase
BW16_RS01540	COG1115	amino acid carrier protein
BW16_RS01545	COG2066	Belongs to the glutaminase family
BW16_RS01550	COG4191	Histidine kinase
BW16_RS01555	COG0784	Response regulator, receiver
BW16_RS01560	COG3012	SEC-C Motif Domain Protein
BW16_RS01560	COG1405	negative regulation of cell septum assembly
BW16_RS01570	COG0667	Aldo Keto reductase
BW16_RS01575	COG3290	protein histidine kinase activity
BW16_RS01580	COG3279	Response regulator of the LytR AlgR family
BW16_RS01585	COG4555	ABC transporter
BW16_RS01590	COG1668	transmembrane transport
BW16_RS01605	COG3773	Cell wall hydrolase
BW16_RS01610	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS01620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS01625	COG2310	stress, protein
BW16_RS01630	COG2310	stress, protein
BW16_RS01635	COG2310	stress, protein
BW16_RS01640	COG0861	Integral membrane protein TerC family
BW16_RS01670	COG3853	Toxic anion resistance protein (TelA)
BW16_RS01675	COG0517	IMP dehydrogenase activity
BW16_RS01675	COG4175	Glycine betaine
BW16_RS01680	COG4176	ABC-type proline glycine betaine transport system permease component
BW16_RS01685	COG2113	Glycine betaine
BW16_RS01700	COG1473	amidohydrolase
BW16_RS01705	COG1288	antiporter activity
BW16_RS01710	COG0039	L-malate dehydrogenase activity
BW16_RS01715	COG1620	l-lactate permease
BW16_RS01720	COG1609	Transcriptional regulator
BW16_RS01725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_RS01730	COG0561	phosphatase activity
BW16_RS01735	COG0673	inositol 2-dehydrogenase activity
BW16_RS01740	COG0738	Major facilitator superfamily
BW16_RS01745	COG1280	lysine exporter protein (LysE YggA)
BW16_RS01760	COG3403	YqcI/YcgG family
BW16_RS01765	COG1113	amino acid transport
BW16_RS01770	COG3665	Urea carboxylase-associated protein
BW16_RS01775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BW16_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS01790	COG0710	3-dehydroquinate dehydratase activity
BW16_RS01795	COG0028	Belongs to the TPP enzyme family
BW16_RS01805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BW16_RS01810	COG2271	Major facilitator Superfamily
BW16_RS01825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW16_RS01830	COG2226	methyltransferase
BW16_RS01835	COG0583	DNA-binding transcription factor activity
BW16_RS01840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW16_RS01845	COG3458	cephalosporin-C deacetylase activity
BW16_RS01855	COG3541	Predicted nucleotidyltransferase
BW16_RS01860	COG0506	proline dehydrogenase activity
BW16_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS01870	COG2508	Transcriptional regulator
BW16_RS01875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW16_RS01880	COG0765	amino acid transport
BW16_RS01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS01895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BW16_RS01900	COG1522	sequence-specific DNA binding
BW16_RS01905	COG2746	aminoglycoside 3-N-acetyltransferase activity
BW16_RS01915	COG0840	transmembrane signaling receptor activity
BW16_RS01915	COG3290	protein histidine kinase activity
BW16_RS01920	COG3209	COG3209 Rhs family protein
BW16_RS01945	COG3842	ATPase activity
BW16_RS01950	COG1176	ABC-type spermidine putrescine transport system, permease component I
BW16_RS01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_RS01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_RS01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BW16_RS01990	COG0697	spore germination
BW16_RS01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS02005	COG3708	Transcriptional regulator
BW16_RS02005	COG2207	Transcriptional regulator
BW16_RS02015	COG2364	Membrane
BW16_RS02020	COG1126	abc transporter atp-binding protein
BW16_RS02025	COG0765	amino acid transport
BW16_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS02035	COG0412	Dienelactone hydrolase
BW16_RS02040	COG0833	amino acid
BW16_RS02045	COG3104	oligopeptide transport
BW16_RS02050	COG5434	Belongs to the glycosyl hydrolase 28 family
BW16_RS02055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS02060	COG0456	acetyltransferase
BW16_RS02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS02070	COG0765	amino acid transport
BW16_RS02075	COG1126	abc transporter atp-binding protein
BW16_RS02080	COG1473	amidohydrolase
BW16_RS02085	COG2079	MmgE PrpD family protein
BW16_RS02095	COG0745	RESPONSE REGULATOR receiver
BW16_RS02100	COG3850	Histidine kinase
BW16_RS02100	COG5002	protein histidine kinase activity
BW16_RS02105	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS02110	COG0527	aspartate kinase activity
BW16_RS02115	COG2814	Major facilitator Superfamily
BW16_RS02120	COG1309	transcriptional regulator
BW16_RS02125	COG0640	Transcriptional regulator
BW16_RS02135	COG0583	DNA-binding transcription factor activity
BW16_RS02140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS02145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BW16_RS02150	COG0531	amino acid
BW16_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS02160	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_RS02165	COG4549	nuclear export factor GLE1
BW16_RS02170	COG1276	copper resistance
BW16_RS02170	COG2372	response to copper ion
BW16_RS02175	COG2213	PTS system mannitol-specific
BW16_RS02180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS02185	COG0246	Mannitol dehydrogenase
BW16_RS02190	COG0840	transmembrane signaling receptor activity
BW16_RS02225	COG0346	lactoylglutathione lyase activity
BW16_RS02235	COG0561	phosphatase activity
BW16_RS02240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BW16_RS02245	COG1914	H( )-stimulated, divalent metal cation uptake system
BW16_RS02250	COG4336	lyase activity
BW16_RS02255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BW16_RS02260	COG1984	allophanate hydrolase subunit 2
BW16_RS02265	COG1414	Transcriptional regulator
BW16_RS02270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_RS02275	COG2755	lipolytic protein G-D-S-L family
BW16_RS02285	COG3711	transcriptional antiterminator
BW16_RS02290	COG2226	methyltransferase
BW16_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS02300	COG3871	stress protein (general stress protein 26)
BW16_RS02325	COG2814	Major facilitator Superfamily
BW16_RS02330	COG1802	Transcriptional regulator
BW16_RS02335	COG1917	Cupin 2, conserved barrel domain protein
BW16_RS02335	COG2207	Transcriptional regulator
BW16_RS02340	COG0697	spore germination
BW16_RS02345	COG0473	3-isopropylmalate dehydrogenase activity
BW16_RS02350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW16_RS02350	COG0551	DNA topoisomerase type I activity
BW16_RS02355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BW16_RS02360	COG3706	GGDEF domain
BW16_RS02365	COG5298	Protein conserved in bacteria
BW16_RS02370	COG1215	transferase activity, transferring glycosyl groups
BW16_RS02380	COG0531	amino acid
BW16_RS02385	COG0028	Belongs to the TPP enzyme family
BW16_RS02390	COG5444	nuclease activity
BW16_RS02410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_RS02415	COG1914	H( )-stimulated, divalent metal cation uptake system
BW16_RS02420	COG2261	transglycosylase associated protein
BW16_RS02425	COG2217	Heavy metal translocating P-type atpase
BW16_RS02430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BW16_RS02435	COG3290	protein histidine kinase activity
BW16_RS02440	COG4565	transcriptional regulatory protein
BW16_RS02445	COG1301	dicarboxylic acid transport
BW16_RS02450	COG0628	permease
BW16_RS02455	COG1301	dicarboxylic acid transport
BW16_RS02460	COG1131	(ABC) transporter
BW16_RS02465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BW16_RS02480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS02485	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW16_RS02490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BW16_RS02505	COG0513	Belongs to the DEAD box helicase family
BW16_RS02510	COG3402	PFAM membrane-flanked domain
BW16_RS02515	COG3428	Bacterial PH domain
BW16_RS02520	COG0705	Rhomboid family
BW16_RS02525	COG0736	holo-[acyl-carrier-protein] synthase activity
BW16_RS02530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BW16_RS02535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW16_RS02540	COG0864	Transcriptional regulator
BW16_RS02545	COG2337	Toxic component of a toxin-antitoxin (TA) module
BW16_RS02550	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS02555	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS02560	COG2172	sigma factor antagonist activity
BW16_RS02565	COG2208	phosphoserine phosphatase activity
BW16_RS02570	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS02575	COG2172	sigma factor antagonist activity
BW16_RS02580	COG1191	sigma factor activity
BW16_RS02585	COG2208	phosphoserine phosphatase activity
BW16_RS02590	COG2183	response to ionizing radiation
BW16_RS02595	COG3091	SprT-like family
BW16_RS02600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_RS02605	COG0022	dehydrogenase e1 component
BW16_RS02610	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS02615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_RS02620	COG3284	Transcriptional regulator
BW16_RS02660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BW16_RS02675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_RS02680	COG0456	acetyltransferase
BW16_RS02680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BW16_RS02685	COG1278	Cold shock
BW16_RS02690	COG1404	Belongs to the peptidase S8 family
BW16_RS02705	COG0789	Transcriptional regulator
BW16_RS02715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_RS02740	COG0477	Major facilitator Superfamily
BW16_RS02745	COG0657	acetylesterase activity
BW16_RS02755	COG4221	oxidoreductase activity
BW16_RS02765	COG0252	asparaginase activity
BW16_RS02770	COG2267	carboxylic ester hydrolase activity
BW16_RS02785	COG2814	Major facilitator Superfamily
BW16_RS02800	COG2801	Transposase and inactivated derivatives
BW16_RS02850	COG1309	transcriptional regulator
BW16_RS02855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW16_RS02860	COG1846	Transcriptional regulator
BW16_RS02865	COG0778	Nitroreductase
BW16_RS02880	COG1396	sequence-specific DNA binding
BW16_RS02890	COG0456	acetyltransferase
BW16_RS02900	COG4122	O-methyltransferase activity
BW16_RS02910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BW16_RS02915	COG0697	spore germination
BW16_RS02925	COG1301	dicarboxylic acid transport
BW16_RS02965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BW16_RS02970	COG0802	atpase or kinase
BW16_RS02975	COG1214	PFAM Peptidase M22, glycoprotease
BW16_RS02980	COG0456	acetyltransferase
BW16_RS02985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW16_RS02990	COG0488	(ABC) transporter
BW16_RS02995	COG0315	cyclic pyranopterin monophosphate synthase activity
BW16_RS03000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BW16_RS03005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW16_RS03010	COG0805	protein transport
BW16_RS03025	COG1266	CAAX protease self-immunity
BW16_RS03030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW16_RS03035	COG0459	protein refolding
BW16_RS03040	COG1846	Transcriptional regulator
BW16_RS03045	COG2808	Putative FMN-binding domain
BW16_RS03050	COG1876	peptidase activity
BW16_RS03075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW16_RS03080	COG0823	Involved in the tonB-independent uptake of proteins
BW16_RS03090	COG2132	Multicopper oxidase
BW16_RS03095	COG1113	amino acid transport
BW16_RS03100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW16_RS03105	COG0714	Associated with various cellular activities
BW16_RS03110	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BW16_RS03115	COG1305	Transglutaminase-like
BW16_RS03120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW16_RS03120	COG0519	Catalyzes the synthesis of GMP from XMP
BW16_RS03125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BW16_RS03135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW16_RS03165	COG3279	Response regulator of the LytR AlgR family
BW16_RS03185	COG1595	DNA-templated transcription, initiation
BW16_RS03195	COG2814	Major facilitator Superfamily
BW16_RS03200	COG0583	DNA-binding transcription factor activity
BW16_RS03205	COG2252	PERMEase
BW16_RS03210	COG5583	Uncharacterized small protein (DUF2292)
BW16_RS03215	COG3064	Membrane
BW16_RS03220	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BW16_RS03230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BW16_RS03235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BW16_RS03240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BW16_RS03245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BW16_RS03250	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW16_RS03255	COG0047	phosphoribosylformylglycinamidine synthase activity
BW16_RS03260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW16_RS03265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BW16_RS03270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BW16_RS03275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BW16_RS03280	COG0138	bifunctional purine biosynthesis protein purh
BW16_RS03285	COG0151	Belongs to the GarS family
BW16_RS03305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BW16_RS03310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BW16_RS03315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BW16_RS03320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW16_RS03330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BW16_RS03335	COG4496	protein, YerC YecD
BW16_RS03345	COG0069	glutamate synthase activity
BW16_RS03360	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BW16_RS03365	COG0210	DNA helicase
BW16_RS03370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BW16_RS03375	COG4851	CamS sex pheromone cAM373 precursor
BW16_RS03380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_RS03385	COG1285	pathogenesis
BW16_RS03390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_RS03395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW16_RS03400	COG0154	amidase activity
BW16_RS03405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW16_RS03410	COG1309	transcriptional regulator
BW16_RS03415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BW16_RS03420	COG1957	nucleoside hydrolase
BW16_RS03425	COG1597	lipid kinase activity
BW16_RS03430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW16_RS03440	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_RS03445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BW16_RS03465	COG0492	ferredoxin-NADP+ reductase activity
BW16_RS03480	COG1486	melibiose metabolic process
BW16_RS03490	COG2211	Major facilitator Superfamily
BW16_RS03515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BW16_RS03520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_RS03525	COG1442	glycosyl transferase family 8
BW16_RS03530	COG1216	Glycosyl transferase, family 2
BW16_RS03535	COG1442	glycosyl transferase family 8
BW16_RS03540	COG2223	nitrite transmembrane transporter activity
BW16_RS03550	COG0471	metal ion transport
BW16_RS03565	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_RS03580	COG0531	amino acid
BW16_RS03585	COG0457	Tetratricopeptide repeat
BW16_RS03585	COG0463	Glycosyl transferase, family 2
BW16_RS03590	COG0488	(ABC) transporter
BW16_RS03595	COG1469	GTP cyclohydrolase I activity
BW16_RS03600	COG0789	Transcriptional regulator
BW16_RS03605	COG2814	Major facilitator Superfamily
BW16_RS03610	COG0488	(ABC) transporter
BW16_RS03615	COG0513	Belongs to the DEAD box helicase family
BW16_RS03640	COG2130	NADP-dependent
BW16_RS03660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_RS03660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_RS03665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW16_RS03675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_RS03675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_RS03685	COG3290	protein histidine kinase activity
BW16_RS03690	COG4565	transcriptional regulatory protein
BW16_RS03695	COG3181	Tripartite tricarboxylate transporter family receptor
BW16_RS03700	COG2851	Citrate transporter
BW16_RS03710	COG3479	Phenolic acid decarboxylase
BW16_RS03715	COG1695	Transcriptional regulator
BW16_RS03720	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BW16_RS03730	COG1254	Belongs to the acylphosphatase family
BW16_RS03735	COG2258	MOSC domain
BW16_RS03740	COG0024	Methionine aminopeptidase
BW16_RS03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS03745	COG1263	PTS System
BW16_RS03750	COG3739	integral membrane protein
BW16_RS03765	COG1368	sulfuric ester hydrolase activity
BW16_RS03770	COG0076	glutamate decarboxylase activity
BW16_RS03785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS03785	COG1263	PTS System
BW16_RS03790	COG0366	Alpha amylase catalytic
BW16_RS03795	COG2188	Transcriptional regulator
BW16_RS03805	COG0737	Belongs to the 5'-nucleotidase family
BW16_RS03810	COG0693	protein deglycase activity
BW16_RS03815	COG4840	Belongs to the UPF0435 family
BW16_RS03820	COG1115	amino acid carrier protein
BW16_RS03830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_RS03835	COG4980	gas vesicle protein
BW16_RS03840	COG1295	ribonuclease BN
BW16_RS03845	COG0477	Major facilitator Superfamily
BW16_RS03855	COG0387	Pfam Sodium calcium exchanger
BW16_RS03865	COG0217	transcriptional regulatory protein
BW16_RS03875	COG0668	transmembrane transport
BW16_RS03880	COG0535	radical SAM domain protein
BW16_RS03890	COG0726	polysaccharide deacetylase
BW16_RS03900	COG0598	Magnesium transport protein CorA
BW16_RS03910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BW16_RS03915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW16_RS03975	COG0789	Transcriptional regulator
BW16_RS03980	COG2814	Major facilitator Superfamily
BW16_RS03995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_RS04040	COG2076	Multidrug Resistance protein
BW16_RS04045	COG2076	Multidrug Resistance protein
BW16_RS04050	COG1309	transcriptional regulator
BW16_RS04060	COG4637	Psort location Cytoplasmic, score
BW16_RS04065	COG2755	lipolytic protein G-D-S-L family
BW16_RS04070	COG0492	ferredoxin-NADP+ reductase activity
BW16_RS04075	COG2169	Transcriptional regulator
BW16_RS04080	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BW16_RS04085	COG1132	(ABC) transporter
BW16_RS04090	COG1742	UPF0060 membrane protein
BW16_RS04095	COG1595	DNA-templated transcription, initiation
BW16_RS04115	COG2318	DinB family
BW16_RS04125	COG1846	Transcriptional regulator
BW16_RS04130	COG0392	lysyltransferase activity
BW16_RS04130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BW16_RS04150	COG0778	Nitroreductase
BW16_RS04160	COG1090	epimerase
BW16_RS04165	COG2137	regulation of response to DNA damage stimulus
BW16_RS04185	COG0463	Glycosyl transferase, family 2
BW16_RS04190	COG4485	Bacterial membrane protein, YfhO
BW16_RS04195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BW16_RS04210	COG2140	Oxalate decarboxylase
BW16_RS04215	COG1191	sigma factor activity
BW16_RS04225	COG1988	membrane-bound metal-dependent
BW16_RS04230	COG1194	a g-specific adenine glycosylase
BW16_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS04255	COG3557	Belongs to the UPF0374 family
BW16_RS04260	COG1132	(ABC) transporter
BW16_RS04265	COG0444	Belongs to the ABC transporter superfamily
BW16_RS04270	COG4608	Belongs to the ABC transporter superfamily
BW16_RS04275	COG0747	negative chemotaxis
BW16_RS04280	COG0601	transmembrane transport
BW16_RS04285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_RS04290	COG4129	membrane
BW16_RS04295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW16_RS04300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BW16_RS04305	COG0735	belongs to the Fur family
BW16_RS04455	COG1368	sulfuric ester hydrolase activity
BW16_RS04460	COG0681	Belongs to the peptidase S26 family
BW16_RS04465	COG2873	o-acetylhomoserine
BW16_RS04485	COG1131	(ABC) transporter
BW16_RS04515	COG3382	B3 4 domain protein
BW16_RS04520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BW16_RS04530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BW16_RS04535	COG2766	serine protein kinase
BW16_RS04540	COG2718	Belongs to the UPF0229 family
BW16_RS04545	COG1566	PFAM secretion protein HlyD family protein
BW16_RS04550	COG2814	Major facilitator Superfamily
BW16_RS04555	COG0655	NAD(P)H dehydrogenase (quinone) activity
BW16_RS04565	COG1278	Cold shock
BW16_RS04570	COG3706	GGDEF domain
BW16_RS04595	COG5577	PFAM Coat F domain
BW16_RS04600	COG5002	protein histidine kinase activity
BW16_RS04605	COG0737	Belongs to the 5'-nucleotidase family
BW16_RS04605	COG4085	toxin activity
BW16_RS04605	COG1525	nuclease
BW16_RS04610	COG3764	Sortase (surface protein transpeptidase)
BW16_RS04615	COG0564	pseudouridine synthase activity
BW16_RS04625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW16_RS04630	COG3153	acetyltransferase
BW16_RS04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW16_RS04650	COG3835	regulator
BW16_RS04655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BW16_RS04660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BW16_RS04665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BW16_RS04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW16_RS04675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BW16_RS04680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW16_RS04685	COG4585	Histidine kinase
BW16_RS04685	COG2203	Gaf domain
BW16_RS04690	COG2197	response regulator
BW16_RS04705	COG0753	catalase activity
BW16_RS04710	COG1959	2 iron, 2 sulfur cluster binding
BW16_RS04715	COG1017	nitric oxide dioxygenase activity
BW16_RS04715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BW16_RS04720	COG2719	SpoVR family
BW16_RS04725	COG1785	Belongs to the alkaline phosphatase family
BW16_RS04730	COG1388	LysM domain
BW16_RS04730	COG0791	NLP P60 protein
BW16_RS04735	COG0531	amino acid
BW16_RS04750	COG1595	DNA-templated transcription, initiation
BW16_RS04755	COG0204	Acyl-transferase
BW16_RS04760	COG1253	flavin adenine dinucleotide binding
BW16_RS04765	COG0789	Transcriptional regulator
BW16_RS04770	COG1253	flavin adenine dinucleotide binding
BW16_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW16_RS04790	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_RS04795	COG0668	transmembrane transport
BW16_RS04800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW16_RS04805	COG0726	polysaccharide deacetylase
BW16_RS04810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_RS04815	COG0589	response to stress
BW16_RS04820	COG1132	(ABC) transporter
BW16_RS04825	COG1132	(ABC) transporter
BW16_RS04830	COG0702	epimerase
BW16_RS04840	COG3842	ATPase activity
BW16_RS04845	COG2508	Transcriptional regulator
BW16_RS04855	COG0189	ligase activity
BW16_RS04860	COG0189	ligase activity
BW16_RS04865	COG4399	Belongs to the UPF0754 family
BW16_RS04870	COG3679	Belongs to the UPF0342 family
BW16_RS04875	COG0561	phosphatase activity
BW16_RS04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BW16_RS04890	COG0475	glutathione-regulated potassium exporter activity
BW16_RS04895	COG0490	domain, Protein
BW16_RS04905	COG1024	Enoyl-CoA hydratase
BW16_RS04915	COG0420	3'-5' exonuclease activity
BW16_RS04920	COG4717	serine-type aminopeptidase activity
BW16_RS04925	COG3481	metal-dependent phosphohydrolase, HD sub domain
BW16_RS04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BW16_RS04960	COG1846	Transcriptional regulator
BW16_RS04965	COG4980	gas vesicle protein
BW16_RS04980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BW16_RS04985	COG0537	adenosine 5'-monophosphoramidase activity
BW16_RS04990	COG1131	(ABC) transporter
BW16_RS04995	COG4473	ABC transporter
BW16_RS05005	COG1473	amidohydrolase
BW16_RS05015	COG2329	Antibiotic biosynthesis monooxygenase
BW16_RS05020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_RS05025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BW16_RS05030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BW16_RS05035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BW16_RS05040	COG1309	transcriptional regulator
BW16_RS05045	COG1511	domain protein
BW16_RS05050	COG1363	Peptidase, m42
BW16_RS05055	COG1301	dicarboxylic acid transport
BW16_RS05060	COG1234	tRNA 3'-trailer cleavage
BW16_RS05065	COG0095	Lipoate-protein ligase
BW16_RS05070	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS05080	COG0501	Belongs to the peptidase M48B family
BW16_RS05085	COG1404	Belongs to the peptidase S8 family
BW16_RS05090	COG0406	alpha-ribazole phosphatase activity
BW16_RS05095	COG0840	transmembrane signaling receptor activity
BW16_RS05100	COG0723	plastoquinol--plastocyanin reductase activity
BW16_RS05100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW16_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS05115	COG4903	ComK protein
BW16_RS05120	COG4974	Belongs to the 'phage' integrase family
BW16_RS05125	COG2856	Zn peptidase
BW16_RS05135	COG1396	sequence-specific DNA binding
BW16_RS05180	COG5377	YqaJ viral recombinase family
BW16_RS05185	COG3723	Recombinational DNA repair protein, rece pathway
BW16_RS05200	COG1484	DNA-dependent DNA replication
BW16_RS05205	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BW16_RS05240	COG3677	Transposase
BW16_RS05255	COG5484	DNA packaging
BW16_RS05360	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS05360	COG5632	N-Acetylmuramoyl-L-alanine amidase
BW16_RS05405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS05410	COG2814	Major facilitator Superfamily
BW16_RS05415	COG2732	(Barnase) inhibitor
BW16_RS05420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS05425	COG4605	iron ion homeostasis
BW16_RS05430	COG4604	ABC transporter, ATP-binding protein
BW16_RS05435	COG4607	ABC-type enterochelin transport system periplasmic component
BW16_RS05440	COG1316	TRANSCRIPTIONal
BW16_RS05455	COG0398	Pfam SNARE associated Golgi protein
BW16_RS05460	COG0681	Belongs to the peptidase S26 family
BW16_RS05465	COG3180	Ammonia monooxygenase
BW16_RS05480	COG2259	Doxx family
BW16_RS05485	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BW16_RS05490	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BW16_RS05495	COG1074	ATP-dependent DNA helicase activity
BW16_RS05500	COG0420	3'-5' exonuclease activity
BW16_RS05505	COG0419	ATPase involved in DNA repair
BW16_RS05510	COG1403	HNH endonuclease
BW16_RS05550	COG5337	Spore coat protein CotH
BW16_RS05560	COG0179	Fumarylacetoacetate (FAA) hydrolase
BW16_RS05575	COG0367	asparagine synthase
BW16_RS05590	COG1562	ergosterol biosynthetic process
BW16_RS05595	COG0534	Mate efflux family protein
BW16_RS05600	COG2207	Transcriptional regulator
BW16_RS05600	COG1917	Cupin 2, conserved barrel domain protein
BW16_RS05625	COG0076	glutamate decarboxylase activity
BW16_RS05660	COG1410	methionine synthase
BW16_RS05660	COG0646	methionine synthase
BW16_RS05665	COG0646	methionine synthase
BW16_RS05665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BW16_RS05670	COG1666	GTP binding
BW16_RS05675	COG2996	Protein conserved in bacteria
BW16_RS05680	COG1744	ABC transporter substrate-binding protein PnrA-like
BW16_RS05685	COG0840	transmembrane signaling receptor activity
BW16_RS05690	COG1307	EDD domain protein, DegV family
BW16_RS05695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_RS05715	COG0561	phosphatase activity
BW16_RS05720	COG1073	alpha beta
BW16_RS05725	COG2151	metal-sulfur cluster biosynthetic enzyme
BW16_RS05730	COG0277	FAD linked oxidase domain protein
BW16_RS05735	COG2271	Major facilitator Superfamily
BW16_RS05740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BW16_RS05745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BW16_RS05750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BW16_RS05755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW16_RS05760	COG0505	Belongs to the CarA family
BW16_RS05765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW16_RS05770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW16_RS05780	COG2814	Major facilitator Superfamily
BW16_RS05790	COG2267	carboxylic ester hydrolase activity
BW16_RS05800	COG1744	ABC transporter substrate-binding protein PnrA-like
BW16_RS05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW16_RS05820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BW16_RS05825	COG5504	Zn-dependent protease
BW16_RS05830	COG0444	Belongs to the ABC transporter superfamily
BW16_RS05835	COG4608	Belongs to the ABC transporter superfamily
BW16_RS05845	COG0601	transmembrane transport
BW16_RS05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_RS05860	COG0180	Tryptophanyl-tRNA synthetase
BW16_RS05865	COG4166	transmembrane transport
BW16_RS05870	COG0601	transmembrane transport
BW16_RS05875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_RS05880	COG0444	Belongs to the ABC transporter superfamily
BW16_RS05885	COG4608	Belongs to the ABC transporter superfamily
BW16_RS05895	COG0456	acetyltransferase
BW16_RS05900	COG1393	Belongs to the ArsC family
BW16_RS05905	COG0861	Integral membrane protein TerC family
BW16_RS05910	COG4862	establishment of competence for transformation
BW16_RS05915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_RS05925	COG1164	Oligoendopeptidase f
BW16_RS05935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW16_RS05940	COG2346	COG2346, Truncated hemoglobins
BW16_RS05945	COG0741	lytic transglycosylase activity
BW16_RS05950	COG4116	CYTH
BW16_RS05960	COG2357	RelA SpoT domain protein
BW16_RS05965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW16_RS05970	COG0564	pseudouridine synthase activity
BW16_RS05975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BW16_RS05980	COG0475	glutathione-regulated potassium exporter activity
BW16_RS05980	COG0569	domain protein
BW16_RS05985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW16_RS05990	COG0352	thiamine-phosphate diphosphorylase activity
BW16_RS06000	COG2104	thiamine diphosphate biosynthetic process
BW16_RS06005	COG2022	thiamine diphosphate biosynthetic process
BW16_RS06010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW16_RS06015	COG0351	phosphomethylpyrimidine kinase
BW16_RS06020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BW16_RS06075	COG0210	DNA helicase
BW16_RS06085	COG2153	protein acetylation
BW16_RS06090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BW16_RS06095	COG2382	esterase
BW16_RS06100	COG0626	cystathionine gamma-synthase activity
BW16_RS06105	COG0626	cystathionine gamma-synthase activity
BW16_RS06115	COG0825	malonyl-CoA metabolic process
BW16_RS06125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_RS06130	COG2807	transmembrane transport
BW16_RS06140	COG0583	DNA-binding transcription factor activity
BW16_RS06150	COG0457	Tetratricopeptide repeat
BW16_RS06165	COG2153	protein acetylation
BW16_RS06170	COG2364	Membrane
BW16_RS06185	COG0300	oxidoreductase activity
BW16_RS06200	COG3173	Aminoglycoside phosphotransferase
BW16_RS06205	COG0583	DNA-binding transcription factor activity
BW16_RS06225	COG0583	DNA-binding transcription factor activity
BW16_RS06230	COG2807	transmembrane transport
BW16_RS06250	COG0457	Tetratricopeptide repeat
BW16_RS06275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW16_RS06285	COG1309	transcriptional regulator
BW16_RS06295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_RS06300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_RS06305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_RS06325	COG4195	phage-related replication protein
BW16_RS06330	COG2856	Zn peptidase
BW16_RS06335	COG5632	N-Acetylmuramoyl-L-alanine amidase
BW16_RS06335	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS06350	COG0306	phosphate transporter
BW16_RS06355	COG1392	Phosphate transport regulator
BW16_RS06365	COG0405	Gamma-glutamyltransferase
BW16_RS06370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BW16_RS06380	COG4208	sulfate ABC transporter
BW16_RS06385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BW16_RS06395	COG3775	system Galactitol-specific IIC component
BW16_RS06410	COG1063	alcohol dehydrogenase
BW16_RS06415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_RS06420	COG0022	dehydrogenase e1 component
BW16_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS06430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS06445	COG2390	Transcriptional regulator
BW16_RS06455	COG0531	amino acid
BW16_RS06460	COG0346	lactoylglutathione lyase activity
BW16_RS06465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_RS06470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_RS06475	COG2362	D-Aminopeptidase
BW16_RS06480	COG0601	transmembrane transport
BW16_RS06485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_RS06490	COG0444	Belongs to the ABC transporter superfamily
BW16_RS06495	COG4166	transmembrane transport
BW16_RS06505	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_RS06510	COG4948	Mandelate Racemase Muconate Lactonizing
BW16_RS06515	COG0791	NLP P60 protein
BW16_RS06520	COG4608	Belongs to the ABC transporter superfamily
BW16_RS06525	COG1834	amidinotransferase
BW16_RS06530	COG1607	acyl-coa hydrolase
BW16_RS06535	COG1695	Transcriptional regulator
BW16_RS06550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_RS06560	COG2076	Multidrug Resistance protein
BW16_RS06565	COG2076	Multidrug Resistance protein
BW16_RS06575	COG0788	formyltetrahydrofolate deformylase activity
BW16_RS06580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW16_RS06585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW16_RS06590	COG0457	Tetratricopeptide repeat
BW16_RS06600	COG1764	response to oxidative stress
BW16_RS06605	COG1846	Transcriptional regulator
BW16_RS06610	COG1764	response to oxidative stress
BW16_RS06615	COG0590	tRNA wobble adenosine to inosine editing
BW16_RS06620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BW16_RS06625	COG1404	Belongs to the peptidase S8 family
BW16_RS06640	COG0745	RESPONSE REGULATOR receiver
BW16_RS06645	COG3850	Histidine kinase
BW16_RS06645	COG5002	protein histidine kinase activity
BW16_RS06650	COG3212	peptidase
BW16_RS06655	COG3212	peptidase
BW16_RS06665	COG2239	Acts as a magnesium transporter
BW16_RS06675	COG0583	DNA-binding transcription factor activity
BW16_RS06685	COG0789	Transcriptional regulator
BW16_RS06695	COG1846	Transcriptional regulator
BW16_RS06700	COG3300	MHYT domain
BW16_RS06700	COG5001	Diguanylate cyclase
BW16_RS06705	COG0586	Pfam SNARE associated Golgi protein
BW16_RS06710	COG0861	Integral membrane protein TerC family
BW16_RS06715	COG1191	sigma factor activity
BW16_RS06735	COG0501	Belongs to the peptidase M48B family
BW16_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BW16_RS06745	COG2323	membrane
BW16_RS06755	COG3594	Acyltransferase
BW16_RS06760	COG5002	protein histidine kinase activity
BW16_RS06765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW16_RS06770	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BW16_RS06775	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BW16_RS06780	COG0436	Aminotransferase
BW16_RS06785	COG1850	ribulose-bisphosphate carboxylase activity
BW16_RS06790	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BW16_RS06795	COG0235	Class ii aldolase
BW16_RS06800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BW16_RS06810	COG3852	Histidine kinase
BW16_RS06815	COG1846	Transcriptional regulator
BW16_RS06820	COG1360	Flagellar Motor Protein
BW16_RS06825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BW16_RS06830	COG0542	response to heat
BW16_RS06835	COG3949	Membrane
BW16_RS06840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BW16_RS06845	COG0720	synthase
BW16_RS06850	COG0602	queuosine metabolic process
BW16_RS06855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BW16_RS06865	COG4873	Protein conserved in bacteria
BW16_RS06875	COG3773	Cell wall hydrolase
BW16_RS06880	COG2244	polysaccharide biosynthetic process
BW16_RS06885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS06890	COG2217	Heavy metal translocating P-type atpase
BW16_RS06895	COG0006	proline dipeptidase activity
BW16_RS06900	COG1609	Transcriptional regulator
BW16_RS06905	COG3711	transcriptional antiterminator
BW16_RS06910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS06910	COG2190	(PTS) system
BW16_RS06910	COG1263	PTS System
BW16_RS06915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS06920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW16_RS06930	COG1533	DNA photolyase activity
BW16_RS06935	COG0840	transmembrane signaling receptor activity
BW16_RS06945	COG2084	Dehydrogenase
BW16_RS06950	COG2340	Cysteine-rich secretory protein family
BW16_RS06955	COG0768	penicillin binding
BW16_RS06960	COG4191	Histidine kinase
BW16_RS06965	COG0436	Aminotransferase
BW16_RS06970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW16_RS06975	COG1714	RDD family
BW16_RS06985	COG0835	chemotaxis
BW16_RS06985	COG0784	Response regulator, receiver
BW16_RS06995	COG2207	Transcriptional regulator
BW16_RS06995	COG1917	Cupin 2, conserved barrel domain protein
BW16_RS07000	COG0697	spore germination
BW16_RS07010	COG2814	Major facilitator Superfamily
BW16_RS07015	COG1376	ErfK ybiS ycfS ynhG family protein
BW16_RS07020	COG1408	metallophosphoesterase
BW16_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS07030	COG2200	EAL domain
BW16_RS07035	COG3546	catalase activity
BW16_RS07040	COG4703	Protein of unknown function (DUF1797)
BW16_RS07045	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BW16_RS07055	COG0517	IMP dehydrogenase activity
BW16_RS07060	COG0583	DNA-binding transcription factor activity
BW16_RS07070	COG0716	FMN binding
BW16_RS07080	COG0716	FMN binding
BW16_RS07085	COG2171	N-acyltransferase activity
BW16_RS07090	COG1473	amidohydrolase
BW16_RS07105	COG0668	transmembrane transport
BW16_RS07110	COG0450	alkyl hydroperoxide reductase
BW16_RS07115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS07130	COG0746	molybdenum cofactor guanylyltransferase activity
BW16_RS07135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW16_RS07140	COG0303	'Molybdopterin
BW16_RS07145	COG1763	Mo-molybdopterin cofactor biosynthetic process
BW16_RS07150	COG0314	molybdopterin synthase activity
BW16_RS07155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BW16_RS07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BW16_RS07175	COG1136	(ABC) transporter
BW16_RS07180	COG0577	efflux transmembrane transporter activity
BW16_RS07185	COG1349	DNA-binding transcription factor activity
BW16_RS07190	COG1105	Belongs to the carbohydrate kinase PfkB family
BW16_RS07195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS07195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS07195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS07200	COG0681	Belongs to the peptidase S26 family
BW16_RS07210	COG0488	(ABC) transporter
BW16_RS07225	COG2309	aminopeptidase activity
BW16_RS07230	COG1077	Cell shape determining protein MreB Mrl
BW16_RS07235	COG2002	toxin-antitoxin pair type II binding
BW16_RS07240	COG3852	Histidine kinase
BW16_RS07245	COG2105	PFAM AIG2 family protein
BW16_RS07245	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BW16_RS07250	COG0569	domain protein
BW16_RS07255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BW16_RS07260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW16_RS07265	COG5503	Protein of unknown function (DUF1447)
BW16_RS07270	COG0561	phosphatase activity
BW16_RS07275	COG0242	peptide deformylase activity
BW16_RS07290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_RS07295	COG0022	dehydrogenase e1 component
BW16_RS07300	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS07305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_RS07310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS07315	COG1982	Orn Lys Arg decarboxylase major
BW16_RS07320	COG4476	Belongs to the UPF0223 family
BW16_RS07325	COG4493	Belongs to the UPF0637 family
BW16_RS07335	COG0483	inositol monophosphate 1-phosphatase activity
BW16_RS07350	COG1595	DNA-templated transcription, initiation
BW16_RS07370	COG1217	gtp-binding protein TYPA
BW16_RS07380	COG4896	Protein conserved in bacteria
BW16_RS07390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW16_RS07395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BW16_RS07400	COG2066	Belongs to the glutaminase family
BW16_RS07405	COG4838	Belongs to the UPF0358 family
BW16_RS07410	COG0772	Belongs to the SEDS family
BW16_RS07415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BW16_RS07420	COG0415	Belongs to the DNA photolyase family
BW16_RS07425	COG1612	heme a metabolic process
BW16_RS07430	COG0109	protoheme IX farnesyltransferase activity
BW16_RS07435	COG2010	Cytochrome c
BW16_RS07435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW16_RS07440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW16_RS07445	COG1845	cytochrome c oxidase, subunit III
BW16_RS07450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BW16_RS07455	COG3336	cytochrome c oxidase
BW16_RS07465	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BW16_RS07470	COG2340	Cysteine-rich secretory protein family
BW16_RS07490	COG3679	Belongs to the UPF0342 family
BW16_RS07495	COG4471	UPF0298 protein
BW16_RS07500	COG0742	ribosomal rna small subunit methyltransferase
BW16_RS07505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW16_RS07510	COG3314	Sporulation integral membrane protein YlbJ
BW16_RS07515	COG1752	Esterase of the alpha-beta hydrolase superfamily
BW16_RS07520	COG3480	Lon protease (S16) C-terminal proteolytic domain
BW16_RS07530	COG1399	metal-binding, possibly nucleic acid-binding protein
BW16_RS07535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW16_RS07545	COG0454	-acetyltransferase
BW16_RS07550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BW16_RS07555	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BW16_RS07560	COG2001	Belongs to the MraZ family
BW16_RS07565	COG0275	rRNA processing
BW16_RS07570	COG4839	cell division protein FtsL
BW16_RS07575	COG0768	penicillin binding
BW16_RS07580	COG0768	penicillin binding
BW16_RS07585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BW16_RS07590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW16_RS07595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW16_RS07600	COG0772	Belongs to the SEDS family
BW16_RS07605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW16_RS07610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW16_RS07615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BW16_RS07620	COG3879	Bacterial protein of unknown function (DUF881)
BW16_RS07625	COG3879	Bacterial protein of unknown function (DUF881)
BW16_RS07630	COG3856	small basic protein
BW16_RS07635	COG0849	cell division
BW16_RS07640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BW16_RS07645	COG1404	Belongs to the peptidase S8 family
BW16_RS07645	COG4412	M6 family metalloprotease domain protein
BW16_RS07655	COG1191	sigma factor activity
BW16_RS07660	COG1191	sigma factor activity
BW16_RS07665	COG2390	Transcriptional regulator
BW16_RS07680	COG3730	PTS system glucitol sorbitol-specific
BW16_RS07685	COG3732	PTS system glucitol sorbitol-specific
BW16_RS07695	COG1119	ATPase activity
BW16_RS07700	COG1873	PFAM PRC-barrel domain
BW16_RS07705	COG1496	oxidoreductase activity
BW16_RS07710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW16_RS07715	COG1799	cell septum assembly
BW16_RS07720	COG0762	integral membrane protein
BW16_RS07725	COG2302	S4 RNA-binding domain
BW16_RS07730	COG3599	regulation of cell shape
BW16_RS07735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BW16_RS07740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_RS07745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW16_RS07750	COG0564	pseudouridine synthase activity
BW16_RS07755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW16_RS07760	COG2233	PERMEase
BW16_RS07765	COG0540	Belongs to the ATCase OTCase family
BW16_RS07770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW16_RS07775	COG0505	Belongs to the CarA family
BW16_RS07780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW16_RS07785	COG0543	2 iron, 2 sulfur cluster binding
BW16_RS07790	COG0167	dihydroorotate dehydrogenase activity
BW16_RS07795	COG0284	orotidine-5'-phosphate decarboxylase activity
BW16_RS07800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW16_RS07805	COG0175	sulfate reduction
BW16_RS07810	COG0306	phosphate transporter
BW16_RS07815	COG2046	Belongs to the sulfate adenylyltransferase family
BW16_RS07820	COG0529	Catalyzes the synthesis of activated sulfate
BW16_RS07825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW16_RS07830	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BW16_RS07835	COG1648	precorrin-2 dehydrogenase activity
BW16_RS07845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW16_RS07850	COG1561	YicC-like family, N-terminal region
BW16_RS07855	COG2052	Domain of unknown function (DUF370)
BW16_RS07860	COG0194	GDP metabolic process
BW16_RS07865	COG1758	RNA polymerase activity
BW16_RS07870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BW16_RS07875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BW16_RS07880	COG0242	peptide deformylase activity
BW16_RS07885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW16_RS07890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BW16_RS07890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW16_RS07895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW16_RS07900	COG0631	protein serine/threonine phosphatase activity
BW16_RS07905	COG0515	serine threonine protein kinase
BW16_RS07905	COG2815	serine threonine protein kinase
BW16_RS07910	COG1162	GTPase activity
BW16_RS07915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW16_RS07920	COG1564	THIamine pyrophosphokinase
BW16_RS07930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW16_RS07935	COG1302	Protein conserved in bacteria
BW16_RS07940	COG1461	Dihydroxyacetone kinase
BW16_RS07945	COG1760	l-serine dehydratase
BW16_RS07950	COG1760	l-serine dehydratase
BW16_RS07955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW16_RS07960	COG1349	DNA-binding transcription factor activity
BW16_RS07965	COG0416	fatty acid biosynthetic process
BW16_RS07970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BW16_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS07980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW16_RS07990	COG1196	nuclear chromosome segregation
BW16_RS07995	COG0552	protein localization to endoplasmic reticulum
BW16_RS08000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BW16_RS08005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BW16_RS08010	COG0228	four-way junction DNA binding
BW16_RS08015	COG1837	Belongs to the UPF0109 family
BW16_RS08025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW16_RS08030	COG0336	Belongs to the RNA methyltransferase TrmD family
BW16_RS08035	COG0335	large ribosomal subunit rRNA binding
BW16_RS08040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BW16_RS08045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW16_RS08055	COG2257	FlhB HrpN YscU SpaS Family
BW16_RS08060	COG0045	succinate-CoA ligase (ADP-forming) activity
BW16_RS08065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BW16_RS08070	COG0758	DNA mediated transformation
BW16_RS08075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW16_RS08080	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BW16_RS08085	COG4974	Belongs to the 'phage' integrase family
BW16_RS08090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BW16_RS08095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BW16_RS08100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BW16_RS08105	COG1815	bacterial-type flagellum-dependent cell motility
BW16_RS08110	COG1558	bacterial-type flagellum-dependent cell motility
BW16_RS08115	COG1677	Flagellar hook-basal body complex protein FliE
BW16_RS08120	COG1766	The M ring may be actively involved in energy transduction
BW16_RS08125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_RS08130	COG1317	bacterial-type flagellum organization
BW16_RS08135	COG1157	protein secretion by the type III secretion system
BW16_RS08140	COG2882	bacterial-type flagellum organization
BW16_RS08145	COG3334	PFAM MgtE intracellular
BW16_RS08150	COG3144	bacterial-type flagellum assembly
BW16_RS08155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BW16_RS08160	COG4786	Flagellar basal body rod
BW16_RS08165	COG1582	Flagellar protein (FlbD)
BW16_RS08170	COG1580	Controls the rotational direction of flagella during chemotaxis
BW16_RS08175	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_RS08180	COG1776	CheC inhibitor of MCP methylation
BW16_RS08180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_RS08185	COG2201	protein-glutamate methylesterase activity
BW16_RS08190	COG3190	flagellar
BW16_RS08195	COG1338	Plays a role in the flagellum-specific transport system
BW16_RS08200	COG1987	bacterial-type flagellum assembly
BW16_RS08205	COG1684	flagellar biosynthetic protein fliR
BW16_RS08210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BW16_RS08215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BW16_RS08220	COG1419	protein localization to endoplasmic reticulum
BW16_RS08225	COG0455	bacterial-type flagellum organization
BW16_RS08230	COG2201	protein-glutamate methylesterase activity
BW16_RS08235	COG2198	Histidine kinase
BW16_RS08235	COG0643	Histidine kinase
BW16_RS08240	COG0835	chemotaxis
BW16_RS08245	COG1776	CheC inhibitor of MCP methylation
BW16_RS08255	COG1191	sigma factor activity
BW16_RS08270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW16_RS08275	COG0528	UMP kinase activity
BW16_RS08280	COG0233	cytoplasmic translational termination
BW16_RS08285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW16_RS08290	COG4589	Belongs to the CDS family
BW16_RS08295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW16_RS08300	COG0750	zinc metalloprotease
BW16_RS08305	COG0442	prolyl-tRNA aminoacylation
BW16_RS08325	COG3693	PFAM glycoside hydrolase, family 10
BW16_RS08335	COG0779	Required for maturation of 30S ribosomal subunits
BW16_RS08340	COG0195	Participates in both transcription termination and antitermination
BW16_RS08345	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BW16_RS08350	COG1358	cellular component organization or biogenesis
BW16_RS08355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW16_RS08360	COG1550	Protein conserved in bacteria
BW16_RS08365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW16_RS08370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW16_RS08375	COG0196	riboflavin kinase activity
BW16_RS08380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW16_RS08385	COG1185	polyribonucleotide nucleotidyltransferase activity
BW16_RS08390	COG0726	polysaccharide deacetylase
BW16_RS08395	COG0612	Peptidase, M16
BW16_RS08405	COG1873	PFAM PRC-barrel domain
BW16_RS08410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_RS08415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BW16_RS08420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BW16_RS08425	COG0527	aspartate kinase activity
BW16_RS08435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW16_RS08440	COG0740	serine-type endopeptidase activity
BW16_RS08450	COG4980	gas vesicle protein
BW16_RS08450	COG1674	ftsk spoiiie
BW16_RS08455	COG2188	Transcriptional regulator
BW16_RS08460	COG2814	Major facilitator Superfamily
BW16_RS08465	COG1033	growth of symbiont in host cell
BW16_RS08465	COG2409	Drug exporters of the RND superfamily
BW16_RS08470	COG0612	Peptidase, M16
BW16_RS08475	COG0612	Peptidase, M16
BW16_RS08485	COG1033	growth of symbiont in host cell
BW16_RS08485	COG2409	Drug exporters of the RND superfamily
BW16_RS08505	COG1426	Protein conserved in bacteria
BW16_RS08510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW16_RS08515	COG1058	Belongs to the CinA family
BW16_RS08515	COG1546	Belongs to the CinA family
BW16_RS08520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BW16_RS08525	COG1418	mRNA catabolic process
BW16_RS08530	COG1692	metallophosphoesterase
BW16_RS08535	COG2359	stage V sporulation protein S
BW16_RS08540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BW16_RS08545	COG1063	alcohol dehydrogenase
BW16_RS08550	COG0156	8-amino-7-oxononanoate synthase activity
BW16_RS08560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW16_RS08565	COG4550	Control of competence regulator ComK, YlbF/YmcA
BW16_RS08575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BW16_RS08580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BW16_RS08600	COG1329	Transcriptional regulator
BW16_RS08605	COG4195	phage-related replication protein
BW16_RS08610	COG0457	Tetratricopeptide repeat
BW16_RS08615	COG1404	Belongs to the peptidase S8 family
BW16_RS08620	COG4195	phage-related replication protein
BW16_RS08625	COG1764	response to oxidative stress
BW16_RS08655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW16_RS08660	COG1923	regulation of RNA biosynthetic process
BW16_RS08675	COG1780	Probably involved in ribonucleotide reductase function
BW16_RS08680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW16_RS08685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW16_RS08690	COG4112	unkown
BW16_RS08700	COG0464	growth
BW16_RS08705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW16_RS08710	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BW16_RS08715	COG0789	Transcriptional regulator
BW16_RS08720	COG0174	glutamine synthetase
BW16_RS08740	COG0457	Tetratricopeptide repeat
BW16_RS08765	COG5444	nuclease activity
BW16_RS08790	COG5646	InterPro IPR014922
BW16_RS08815	COG0457	Tetratricopeptide repeat
BW16_RS08825	COG3619	membrane
BW16_RS08830	COG1793	dna ligase
BW16_RS08830	COG3285	dna ligase
BW16_RS08835	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BW16_RS08840	COG4876	unkown
BW16_RS08850	COG1959	2 iron, 2 sulfur cluster binding
BW16_RS08855	COG0702	epimerase
BW16_RS08860	COG0247	lactate metabolic process
BW16_RS08865	COG1139	Iron-sulfur cluster binding protein
BW16_RS08870	COG1556	Lactate utilization protein
BW16_RS08890	COG2323	membrane
BW16_RS08895	COG1309	transcriptional regulator
BW16_RS08900	COG2124	cytochrome p450
BW16_RS08900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BW16_RS08905	COG3591	Belongs to the peptidase S1B family
BW16_RS08910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BW16_RS08915	COG3209	COG3209 Rhs family protein
BW16_RS08920	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS08935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW16_RS08940	COG1388	LysM domain
BW16_RS08945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BW16_RS08950	COG4224	UPF0291 protein
BW16_RS08955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BW16_RS08965	COG3763	UPF0154 protein
BW16_RS08975	COG0785	Cytochrome C biogenesis protein
BW16_RS08980	COG4846	Membrane protein involved in cytochrome C biogenesis
BW16_RS08990	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_RS09005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BW16_RS09010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS09025	COG0824	Thioesterase
BW16_RS09035	COG4841	protein insertion into membrane
BW16_RS09040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BW16_RS09045	COG1832	CoA-binding protein
BW16_RS09050	COG0187	DNA topoisomerase II activity
BW16_RS09055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW16_RS09065	COG0738	Major facilitator superfamily
BW16_RS09070	COG0473	3-isopropylmalate dehydrogenase activity
BW16_RS09075	COG0110	maltose O-acetyltransferase activity
BW16_RS09080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_RS09085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW16_RS09090	COG0640	Transcriptional regulator
BW16_RS09105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW16_RS09110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_RS09120	COG1309	transcriptional regulator
BW16_RS09125	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_RS09130	COG1733	regulation of RNA biosynthetic process
BW16_RS09135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_RS09140	COG0251	oxidation-reduction process
BW16_RS09175	COG0657	acetylesterase activity
BW16_RS09180	COG0789	Transcriptional regulator
BW16_RS09185	COG2723	6-phospho-beta-galactosidase activity
BW16_RS09190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS09190	COG1263	PTS System
BW16_RS09190	COG2190	(PTS) system
BW16_RS09205	COG2205	protein histidine kinase activity
BW16_RS09210	COG0745	RESPONSE REGULATOR receiver
BW16_RS09220	COG3507	Belongs to the glycosyl hydrolase 43 family
BW16_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS09230	COG1486	melibiose metabolic process
BW16_RS09235	COG0395	ABC-type sugar transport system, permease component
BW16_RS09240	COG1175	transmembrane transport
BW16_RS09245	COG1653	transport
BW16_RS09250	COG1609	Transcriptional regulator
BW16_RS09255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW16_RS09270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS09280	COG0456	acetyltransferase
BW16_RS09285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS09315	COG1846	Transcriptional regulator
BW16_RS09320	COG2814	Major facilitator Superfamily
BW16_RS09330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS09330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS09330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS09335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS09335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS09335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_RS09340	COG1105	Belongs to the carbohydrate kinase PfkB family
BW16_RS09350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_RS09385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BW16_RS09400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW16_RS09405	COG1024	Enoyl-CoA hydratase
BW16_RS09415	COG0511	ligase activity, forming carbon-carbon bonds
BW16_RS09420	COG0439	Biotin carboxylase
BW16_RS09425	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS09430	COG1960	acyl-CoA dehydrogenase activity
BW16_RS09435	COG1649	PFAM Uncharacterised BCR, COG1649
BW16_RS09440	COG2365	Tyrosine phosphatase family
BW16_RS09445	COG1349	DNA-binding transcription factor activity
BW16_RS09450	COG1942	4-Oxalocrotonate Tautomerase
BW16_RS09460	COG3835	regulator
BW16_RS09465	COG0277	FAD linked oxidase domain protein
BW16_RS09470	COG0247	lactate metabolic process
BW16_RS09490	COG0166	Belongs to the GPI family
BW16_RS09495	COG2246	polysaccharide biosynthetic process
BW16_RS09500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BW16_RS09505	COG0586	Pfam SNARE associated Golgi protein
BW16_RS09510	COG1587	Uroporphyrinogen-III synthase
BW16_RS09520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS09535	COG0534	Mate efflux family protein
BW16_RS09540	COG2027	D-alanyl-D-alanine carboxypeptidase
BW16_RS09545	COG4677	pectinesterase activity
BW16_RS09550	COG2323	membrane
BW16_RS09555	COG2146	nitrite reductase [NAD(P)H] activity
BW16_RS09560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BW16_RS09565	COG0243	molybdopterin cofactor binding
BW16_RS09570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BW16_RS09575	COG2223	nitrite transmembrane transporter activity
BW16_RS09580	COG0493	'glutamate synthase
BW16_RS09585	COG0069	glutamate synthase activity
BW16_RS09585	COG0070	glutamate synthase
BW16_RS09585	COG0067	glutamate synthase
BW16_RS09590	COG0583	DNA-binding transcription factor activity
BW16_RS09600	COG1132	(ABC) transporter
BW16_RS09605	COG0789	Transcriptional regulator
BW16_RS09605	COG4978	Transcriptional regulator
BW16_RS09610	COG0454	-acetyltransferase
BW16_RS09615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW16_RS09620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW16_RS09625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_RS09635	COG0243	molybdopterin cofactor binding
BW16_RS09645	COG1070	Carbohydrate kinase
BW16_RS09650	COG2115	Belongs to the xylose isomerase family
BW16_RS09655	COG1940	carbohydrate kinase activity
BW16_RS09665	COG2211	Major facilitator Superfamily
BW16_RS09670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_RS09675	COG1994	Peptidase M50
BW16_RS09695	COG1309	transcriptional regulator
BW16_RS09700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS09705	COG3708	Transcriptional regulator
BW16_RS09710	COG2378	regulation of single-species biofilm formation
BW16_RS09720	COG0640	Transcriptional regulator
BW16_RS09725	COG0531	amino acid
BW16_RS09730	COG0741	lytic transglycosylase activity
BW16_RS09735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BW16_RS09740	COG2079	MmgE PrpD family protein
BW16_RS09745	COG0372	Belongs to the citrate synthase family
BW16_RS09750	COG2322	membrane
BW16_RS09760	COG1388	LysM domain
BW16_RS09760	COG3584	3D domain protein
BW16_RS09765	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_RS09770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS09800	COG1657	PFAM Prenyltransferase squalene oxidase
BW16_RS09805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BW16_RS09810	COG0385	Bile acid
BW16_RS09815	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS09825	COG4548	von Willebrand factor, type A
BW16_RS09830	COG0714	Associated with various cellular activities
BW16_RS09835	COG2032	superoxide dismutase activity
BW16_RS09840	COG1388	LysM domain
BW16_RS09840	COG0791	NLP P60 protein
BW16_RS09845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BW16_RS09850	COG0534	Mate efflux family protein
BW16_RS09855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_RS09860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_RS09870	COG2962	Rard protein
BW16_RS09885	COG1733	regulation of RNA biosynthetic process
BW16_RS09890	COG0778	Nitroreductase
BW16_RS09900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_RS09905	COG0793	Belongs to the peptidase S41A family
BW16_RS09905	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS09910	COG2226	methyltransferase
BW16_RS09920	COG1876	peptidase activity
BW16_RS09925	COG0813	purine-nucleoside phosphorylase activity
BW16_RS09935	COG0671	phosphoesterase, PA-phosphatase related
BW16_RS09945	COG4479	Belongs to the UPF0346 family
BW16_RS09955	COG1509	lysine 2,3-aminomutase activity
BW16_RS09960	COG3829	transcription factor binding
BW16_RS09965	COG0463	Glycosyl transferase, family 2
BW16_RS09980	COG4641	Protein conserved in bacteria
BW16_RS09990	COG1086	Polysaccharide biosynthesis protein
BW16_RS09995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW16_RS10000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW16_RS10005	COG1846	Transcriptional regulator
BW16_RS10025	COG4698	Protein conserved in bacteria
BW16_RS10030	COG2755	lipolytic protein G-D-S-L family
BW16_RS10035	COG1999	signal sequence binding
BW16_RS10050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BW16_RS10055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BW16_RS10060	COG1272	protein, Hemolysin III
BW16_RS10065	COG0204	Acyl-transferase
BW16_RS10070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW16_RS10075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BW16_RS10080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BW16_RS10090	COG2521	methyltransferase
BW16_RS10090	COG2136	Putative SAM-dependent methyltransferase
BW16_RS10100	COG0129	dihydroxy-acid dehydratase activity
BW16_RS10105	COG1413	lyase activity
BW16_RS10110	COG1418	mRNA catabolic process
BW16_RS10115	COG0386	Belongs to the glutathione peroxidase family
BW16_RS10120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW16_RS10130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW16_RS10140	COG1278	Cold shock
BW16_RS10155	COG0328	RNA-DNA hybrid ribonuclease activity
BW16_RS10160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BW16_RS10165	COG0328	RNA-DNA hybrid ribonuclease activity
BW16_RS10175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_RS10185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BW16_RS10190	COG1755	Isoprenylcysteine carboxyl methyltransferase
BW16_RS10195	COG3424	synthase
BW16_RS10200	COG0726	polysaccharide deacetylase
BW16_RS10205	COG2233	PERMEase
BW16_RS10210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_RS10215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BW16_RS10220	COG1199	ATP-dependent helicase activity
BW16_RS10230	COG0116	Belongs to the methyltransferase superfamily
BW16_RS10235	COG3599	regulation of cell shape
BW16_RS10240	COG4474	Belongs to the UPF0398 family
BW16_RS10245	COG3359	exonuclease
BW16_RS10250	COG1205	dead DEAH box helicase
BW16_RS10250	COG1111	helicase
BW16_RS10255	COG1902	pentaerythritol trinitrate reductase activity
BW16_RS10260	COG2190	(PTS) system
BW16_RS10265	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_RS10295	COG3331	DNA recombination
BW16_RS10300	COG4499	WXG100 protein secretion system (Wss), protein YukC
BW16_RS10300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_RS10310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BW16_RS10315	COG3935	DnaD domain protein
BW16_RS10320	COG0017	Asparaginyl-tRNA synthetase
BW16_RS10325	COG5353	protein conserved in bacteria
BW16_RS10330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BW16_RS10330	COG1199	ATP-dependent helicase activity
BW16_RS10335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BW16_RS10340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BW16_RS10345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BW16_RS10355	COG0617	tRNA 3'-terminal CCA addition
BW16_RS10360	COG0438	transferase activity, transferring glycosyl groups
BW16_RS10365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_RS10370	COG1803	Methylglyoxal synthase
BW16_RS10375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW16_RS10380	COG1694	Mazg nucleotide pyrophosphohydrolase
BW16_RS10385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_RS10395	COG4347	Protein of unknown function (DUF1405)
BW16_RS10400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW16_RS10400	COG2010	Cytochrome c
BW16_RS10405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW16_RS10410	COG0723	plastoquinol--plastocyanin reductase activity
BW16_RS10420	COG5582	Belongs to the UPF0302 family
BW16_RS10425	COG0457	Tetratricopeptide repeat
BW16_RS10430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BW16_RS10435	COG0287	Prephenate dehydrogenase
BW16_RS10440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW16_RS10445	COG0159	tryptophan synthase activity
BW16_RS10450	COG0133	tryptophan synthase activity
BW16_RS10455	COG0135	phosphoribosylanthranilate isomerase activity
BW16_RS10460	COG0134	indole-3-glycerol-phosphate synthase activity
BW16_RS10465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BW16_RS10475	COG4401	Chorismate mutase type I
BW16_RS10480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BW16_RS10485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BW16_RS10490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BW16_RS10495	COG0105	UTP biosynthetic process
BW16_RS10500	COG0142	geranyltranstransferase activity
BW16_RS10505	COG2226	methyltransferase
BW16_RS10510	COG0142	geranyltranstransferase activity
BW16_RS10520	COG0302	gtp cyclohydrolase
BW16_RS10525	COG0776	regulation of translation
BW16_RS10530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BW16_RS10545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BW16_RS10550	COG1160	GTP binding
BW16_RS10570	COG1304	FMN binding
BW16_RS10575	COG0539	negative regulation of cytoplasmic translation
BW16_RS10580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW16_RS10590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BW16_RS10595	COG2959	enzyme of heme biosynthesis
BW16_RS10600	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS10600	COG3773	Cell wall hydrolase
BW16_RS10605	COG2339	peptidase activity
BW16_RS10610	COG0492	ferredoxin-NADP+ reductase activity
BW16_RS10615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_RS10620	COG4862	establishment of competence for transformation
BW16_RS10625	COG1408	metallophosphoesterase
BW16_RS10635	COG1388	LysM domain
BW16_RS10640	COG1266	CAAX protease self-immunity
BW16_RS10645	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_RS10650	COG4955	Helix-turn-helix domain
BW16_RS10655	COG1141	Ferredoxin
BW16_RS10660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BW16_RS10665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BW16_RS10680	COG1595	DNA-templated transcription, initiation
BW16_RS10685	COG5002	protein histidine kinase activity
BW16_RS10690	COG0745	RESPONSE REGULATOR receiver
BW16_RS10695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW16_RS10700	COG1333	cytochrome c biogenesis protein
BW16_RS10705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS10710	COG1187	pseudouridine synthase activity
BW16_RS10715	COG0700	Nucleoside recognition
BW16_RS10720	COG2715	membrane protein required for spore maturation
BW16_RS10725	COG1686	Belongs to the peptidase S11 family
BW16_RS10735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW16_RS10740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BW16_RS10745	COG1547	Domain of unknown function (DUF309)
BW16_RS10750	COG0456	acetyltransferase
BW16_RS10755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BW16_RS10765	COG0307	riboflavin synthase, alpha
BW16_RS10785	COG2814	Major facilitator Superfamily
BW16_RS10790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW16_RS10795	COG4086	secreted protein
BW16_RS10800	COG0019	diaminopimelate decarboxylase activity
BW16_RS10805	COG0697	spore germination
BW16_RS10820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW16_RS10840	COG1191	sigma factor activity
BW16_RS10845	COG2172	sigma factor antagonist activity
BW16_RS10855	COG1686	Belongs to the peptidase S11 family
BW16_RS10860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BW16_RS10865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BW16_RS10870	COG4974	Belongs to the 'phage' integrase family
BW16_RS10880	COG0735	belongs to the Fur family
BW16_RS10885	COG1300	Membrane
BW16_RS10890	COG1404	Belongs to the peptidase S8 family
BW16_RS10900	COG2153	protein acetylation
BW16_RS10905	COG1379	DNA repair
BW16_RS10910	COG0494	nUDIX hydrolase
BW16_RS10915	COG0667	Aldo Keto reductase
BW16_RS10925	COG1073	alpha beta
BW16_RS10930	COG0457	Tetratricopeptide repeat
BW16_RS10940	COG4918	Iron-sulphur cluster biosynthesis
BW16_RS10945	COG4305	rare lipoprotein A
BW16_RS10950	COG0456	acetyltransferase
BW16_RS10950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BW16_RS10955	COG0456	acetyltransferase
BW16_RS10965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW16_RS10975	COG2211	Major facilitator Superfamily
BW16_RS10980	COG2801	Transposase and inactivated derivatives
BW16_RS10990	COG1072	(Pantothenic acid kinase))
BW16_RS10995	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW16_RS11005	COG0300	oxidoreductase activity
BW16_RS11010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS11015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_RS11025	COG4187	Peptidase family M20/M25/M40
BW16_RS11030	COG1902	pentaerythritol trinitrate reductase activity
BW16_RS11035	COG0596	Alpha beta hydrolase
BW16_RS11040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_RS11050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BW16_RS11055	COG2188	Transcriptional regulator
BW16_RS11060	COG2723	6-phospho-beta-galactosidase activity
BW16_RS11065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS11070	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_RS11075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS11090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BW16_RS11095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW16_RS11105	COG0706	membrane insertase activity
BW16_RS11110	COG0835	chemotaxis
BW16_RS11115	COG2195	Cleaves the N-terminal amino acid of tripeptides
BW16_RS11120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW16_RS11125	COG0346	lactoylglutathione lyase activity
BW16_RS11130	COG1376	ErfK ybiS ycfS ynhG family protein
BW16_RS11135	COG4129	membrane
BW16_RS11140	COG1126	abc transporter atp-binding protein
BW16_RS11145	COG0765	amino acid transport
BW16_RS11150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS11160	COG1597	lipid kinase activity
BW16_RS11170	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_RS11175	COG0022	dehydrogenase e1 component
BW16_RS11180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_RS11190	COG3426	butyrate kinase activity
BW16_RS11195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_RS11200	COG0280	phosphate acetyltransferase
BW16_RS11205	COG3290	protein histidine kinase activity
BW16_RS11205	COG3829	transcription factor binding
BW16_RS11215	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_RS11220	COG0457	Tetratricopeptide repeat
BW16_RS11225	COG0745	RESPONSE REGULATOR receiver
BW16_RS11230	COG0750	zinc metalloprotease
BW16_RS11235	COG0497	DNA recombination
BW16_RS11240	COG1438	arginine binding
BW16_RS11245	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BW16_RS11250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW16_RS11255	COG0142	geranyltranstransferase activity
BW16_RS11260	COG1722	exodeoxyribonuclease VII activity
BW16_RS11265	COG1570	exodeoxyribonuclease VII activity
BW16_RS11270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW16_RS11275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW16_RS11280	COG1302	Protein conserved in bacteria
BW16_RS11285	COG0439	Biotin carboxylase
BW16_RS11290	COG0511	ligase activity, forming carbon-carbon bonds
BW16_RS11330	COG3854	ATPases associated with a variety of cellular activities
BW16_RS11340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW16_RS11345	COG0006	proline dipeptidase activity
BW16_RS11350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BW16_RS11360	COG3872	metal-dependent enzyme
BW16_RS11370	COG1752	Esterase of the alpha-beta hydrolase superfamily
BW16_RS11375	COG1321	iron dependent repressor
BW16_RS11380	COG0095	Lipoate-protein ligase
BW16_RS11385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_RS11390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW16_RS11395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW16_RS11400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BW16_RS11405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW16_RS11425	COG0681	Belongs to the peptidase S26 family
BW16_RS11460	COG4970	Tfp pilus assembly protein FimT
BW16_RS11465	COG4537	Required for transformation and DNA binding
BW16_RS11470	COG1459	type II secretion system
BW16_RS11475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BW16_RS11480	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS11490	COG1393	Belongs to the ArsC family
BW16_RS11500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS11510	COG0011	TIGRFAM Protein of
BW16_RS11515	COG2814	Major facilitator Superfamily
BW16_RS11520	COG2866	Carboxypeptidase
BW16_RS11525	COG1368	sulfuric ester hydrolase activity
BW16_RS11530	COG1940	carbohydrate kinase activity
BW16_RS11535	COG4483	Protein conserved in bacteria
BW16_RS11540	COG0457	Tetratricopeptide repeat
BW16_RS11540	COG0705	Rhomboid family
BW16_RS11550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BW16_RS11555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW16_RS11570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BW16_RS11575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW16_RS11580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW16_RS11585	COG0581	inorganic phosphate transmembrane transporter activity
BW16_RS11590	COG0573	inorganic phosphate transmembrane transporter activity
BW16_RS11595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BW16_RS11600	COG0768	penicillin binding
BW16_RS11605	COG0477	Major facilitator Superfamily
BW16_RS11610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BW16_RS11615	COG2839	Protein conserved in bacteria
BW16_RS11620	COG5521	maltodextrose utilization protein MalA
BW16_RS11625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_RS11630	COG1388	LysM domain
BW16_RS11635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW16_RS11640	COG4709	membrane
BW16_RS11645	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BW16_RS11650	COG1940	carbohydrate kinase activity
BW16_RS11655	COG0735	belongs to the Fur family
BW16_RS11660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW16_RS11665	COG1121	(ABC) transporter
BW16_RS11670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_RS11685	COG0513	Belongs to the DEAD box helicase family
BW16_RS11695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW16_RS11700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BW16_RS11705	COG2384	SAM-dependent methyltransferase
BW16_RS11710	COG2010	Cytochrome c
BW16_RS11715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW16_RS11720	COG0358	DNA primase activity
BW16_RS11725	COG1671	Belongs to the UPF0178 family
BW16_RS11730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BW16_RS11735	COG0517	IMP dehydrogenase activity
BW16_RS11740	COG0751	glycine-tRNA ligase activity
BW16_RS11745	COG0752	glycyl-tRNA synthetase alpha subunit
BW16_RS11750	COG1381	Involved in DNA repair and RecF pathway recombination
BW16_RS11755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW16_RS11760	COG0295	cytidine deaminase activity
BW16_RS11765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BW16_RS11770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW16_RS11775	COG1480	7TM receptor with intracellular HD hydrolase
BW16_RS11780	COG1702	phosphate starvation-inducible protein PhoH
BW16_RS11785	COG0561	phosphatase activity
BW16_RS11800	COG4864	UPF0365 protein
BW16_RS11805	COG1030	water channel activity
BW16_RS11810	COG1610	YqeY-like protein
BW16_RS11820	COG1283	sodium-dependent phosphate transmembrane transporter activity
BW16_RS11825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW16_RS11830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BW16_RS11835	COG2264	protein methyltransferase activity
BW16_RS11840	COG0484	heat shock protein binding
BW16_RS11845	COG0443	Heat shock 70 kDa protein
BW16_RS11850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW16_RS11855	COG1420	regulation of RNA biosynthetic process
BW16_RS11860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BW16_RS11865	COG0481	GTPase activity
BW16_RS11875	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_RS11880	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BW16_RS11885	COG0268	Binds directly to 16S ribosomal RNA
BW16_RS11890	COG1466	dna polymerase III delta subunit
BW16_RS11900	COG2333	competence protein COMEC
BW16_RS11900	COG0658	competence protein
BW16_RS11905	COG2131	deaminase
BW16_RS11910	COG1596	polysaccharide export
BW16_RS11910	COG1555	photosystem II stabilization
BW16_RS11915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_RS11920	COG2226	methyltransferase
BW16_RS11925	COG0799	negative regulation of ribosome biogenesis
BW16_RS11930	COG1713	HD superfamily hydrolase involved in NAD metabolism
BW16_RS11935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW16_RS11940	COG1534	Rna-binding protein
BW16_RS11945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW16_RS11950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BW16_RS11955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BW16_RS11965	COG2755	lipolytic protein G-D-S-L family
BW16_RS11975	COG0457	Tetratricopeptide repeat
BW16_RS11990	COG2186	Transcriptional regulator
BW16_RS12005	COG3958	Transketolase
BW16_RS12010	COG3959	Transketolase, thiamine diphosphate binding domain
BW16_RS12035	COG0726	polysaccharide deacetylase
BW16_RS12070	COG1122	ATPase activity
BW16_RS12095	COG2160	L-arabinose isomerase activity
BW16_RS12110	COG1609	Transcriptional regulator
BW16_RS12130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BW16_RS12135	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BW16_RS12140	COG1733	regulation of RNA biosynthetic process
BW16_RS12145	COG0657	acetylesterase activity
BW16_RS12200	COG2602	Beta-lactamase
BW16_RS12205	COG1960	acyl-CoA dehydrogenase activity
BW16_RS12210	COG1126	abc transporter atp-binding protein
BW16_RS12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS12220	COG0765	amino acid transport
BW16_RS12230	COG3546	catalase activity
BW16_RS12235	COG1063	alcohol dehydrogenase
BW16_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS12255	COG1115	amino acid carrier protein
BW16_RS12260	COG0583	DNA-binding transcription factor activity
BW16_RS12265	COG1063	alcohol dehydrogenase
BW16_RS12270	COG2226	methyltransferase
BW16_RS12280	COG0626	cystathionine gamma-synthase activity
BW16_RS12285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_RS12290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BW16_RS12295	COG2226	methyltransferase
BW16_RS12310	COG0768	penicillin binding
BW16_RS12315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW16_RS12320	COG0572	uridine kinase
BW16_RS12325	COG0826	peptidase U32
BW16_RS12330	COG0826	peptidase U32
BW16_RS12335	COG4122	O-methyltransferase activity
BW16_RS12340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BW16_RS12345	COG0183	Belongs to the thiolase family
BW16_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS12355	COG1268	BioY protein
BW16_RS12360	COG3906	Belongs to the UPF0473 family
BW16_RS12365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW16_RS12370	COG4472	Bacterial protein of unknown function (DUF965)
BW16_RS12375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW16_RS12380	COG0628	permease
BW16_RS12385	COG1126	abc transporter atp-binding protein
BW16_RS12390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS12395	COG0765	amino acid transport
BW16_RS12400	COG0765	amino acid transport
BW16_RS12410	COG3881	PFAM PRC-barrel domain
BW16_RS12415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW16_RS12420	COG0457	Tetratricopeptide repeat
BW16_RS12425	COG0482	sulfurtransferase activity
BW16_RS12430	COG1104	cysteine desulfurase activity
BW16_RS12435	COG1959	2 iron, 2 sulfur cluster binding
BW16_RS12440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BW16_RS12445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BW16_RS12455	COG0124	histidyl-tRNA synthetase
BW16_RS12460	COG4991	sh3 domain protein
BW16_RS12460	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_RS12460	COG3103	Sh3 type 3 domain protein
BW16_RS12465	COG1490	D-aminoacyl-tRNA deacylase activity
BW16_RS12470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW16_RS12475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_RS12480	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BW16_RS12480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BW16_RS12485	COG5416	Lipopolysaccharide assembly protein A domain
BW16_RS12490	COG0490	domain, Protein
BW16_RS12495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW16_RS12495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW16_RS12505	COG2244	polysaccharide biosynthetic process
BW16_RS12510	COG2323	membrane
BW16_RS12520	COG1862	Preprotein translocase
BW16_RS12525	COG0343	queuine tRNA-ribosyltransferase activity
BW16_RS12530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BW16_RS12540	COG2255	four-way junction helicase activity
BW16_RS12545	COG0632	four-way junction helicase activity
BW16_RS12555	COG2112	serine threonine protein kinase
BW16_RS12565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BW16_RS12580	COG1388	LysM domain
BW16_RS12585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BW16_RS12590	COG0157	Belongs to the NadC ModD family
BW16_RS12595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BW16_RS12600	COG1104	cysteine desulfurase activity
BW16_RS12605	COG1827	regulation of RNA biosynthetic process
BW16_RS12610	COG0077	Prephenate dehydratase
BW16_RS12615	COG4492	Belongs to the UPF0735 family
BW16_RS12620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW16_RS12625	COG3290	protein histidine kinase activity
BW16_RS12630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW16_RS12635	COG2868	ribosomal protein
BW16_RS12640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW16_RS12645	COG1994	Peptidase M50
BW16_RS12650	COG0739	heme binding
BW16_RS12655	COG2894	cell division
BW16_RS12660	COG0850	regulation of cytokinetic process
BW16_RS12665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BW16_RS12675	COG1077	Cell shape determining protein MreB Mrl
BW16_RS12680	COG2003	Belongs to the UPF0758 family
BW16_RS12685	COG0424	maF-like protein
BW16_RS12700	COG0285	dihydrofolate synthase activity
BW16_RS12705	COG0525	valine-tRNA ligase activity
BW16_RS12715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_RS12720	COG1388	LysM domain
BW16_RS12725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW16_RS12730	COG0113	porphobilinogen synthase activity
BW16_RS12735	COG1587	Uroporphyrinogen-III synthase
BW16_RS12740	COG0181	hydroxymethylbilane synthase activity
BW16_RS12745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW16_RS12750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW16_RS12760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BW16_RS12765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BW16_RS12770	COG0470	DNA polymerase III
BW16_RS12770	COG1067	ATP-dependent peptidase activity
BW16_RS12775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BW16_RS12780	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW16_RS12785	COG0457	Tetratricopeptide repeat
BW16_RS12785	COG1477	protein flavinylation
BW16_RS12790	COG0066	3-isopropylmalate dehydratase activity
BW16_RS12795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BW16_RS12800	COG0473	3-isopropylmalate dehydrogenase activity
BW16_RS12805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW16_RS12810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BW16_RS12815	COG0440	acetolactate synthase activity
BW16_RS12820	COG0028	Belongs to the TPP enzyme family
BW16_RS12825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_RS12830	COG2706	6-phosphogluconolactonase activity
BW16_RS12835	COG3339	Conserved Protein
BW16_RS12840	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BW16_RS12845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW16_RS12850	COG1696	Membrane protein involved in D-alanine export
BW16_RS12855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_RS12860	COG5444	nuclease activity
BW16_RS12885	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BW16_RS12890	COG5444	nuclease activity
BW16_RS12905	COG0622	Phosphoesterase
BW16_RS12910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW16_RS12915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BW16_RS12920	COG5401	PFAM Sporulation and spore germination
BW16_RS12925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW16_RS12930	COG1846	Transcriptional regulator
BW16_RS12935	COG2197	response regulator
BW16_RS12940	COG2851	Citrate transporter
BW16_RS12945	COG0583	DNA-binding transcription factor activity
BW16_RS12950	COG2828	Protein conserved in bacteria
BW16_RS12960	COG0824	Thioesterase
BW16_RS12965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW16_RS12970	COG1053	succinate dehydrogenase
BW16_RS12975	COG2009	succinate dehydrogenase
BW16_RS12980	COG1719	4-vinyl reductase, 4VR
BW16_RS12985	COG0527	aspartate kinase activity
BW16_RS12990	COG0322	excinuclease ABC activity
BW16_RS12995	COG3118	belongs to the thioredoxin family
BW16_RS13000	COG3534	alpha-L-arabinofuranosidase
BW16_RS13010	COG2086	electron transfer activity
BW16_RS13015	COG1024	Enoyl-CoA hydratase
BW16_RS13020	COG1309	transcriptional regulator
BW16_RS13025	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS13035	COG3766	membrane
BW16_RS13045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW16_RS13045	COG1796	DNA polymerase
BW16_RS13050	COG1286	toxin biosynthetic process
BW16_RS13055	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BW16_RS13060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW16_RS13065	COG0072	phenylalanine-tRNA ligase activity
BW16_RS13065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_RS13070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW16_RS13075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW16_RS13085	COG1966	Carbon starvation protein
BW16_RS13090	COG1363	Peptidase, m42
BW16_RS13100	COG3326	Membrane
BW16_RS13105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW16_RS13110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW16_RS13115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW16_RS13125	COG1011	Hydrolase
BW16_RS13135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_RS13145	COG0398	Pfam SNARE associated Golgi protein
BW16_RS13150	COG1484	DNA-dependent DNA replication
BW16_RS13155	COG3611	Membrane attachment protein
BW16_RS13160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW16_RS13170	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BW16_RS13175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW16_RS13180	COG0237	dephospho-CoA kinase activity
BW16_RS13185	COG1971	Probably functions as a manganese efflux pump
BW16_RS13190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW16_RS13195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_RS13195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_RS13200	COG5002	protein histidine kinase activity
BW16_RS13205	COG0745	RESPONSE REGULATOR receiver
BW16_RS13210	COG0039	L-malate dehydrogenase activity
BW16_RS13215	COG0538	isocitrate dehydrogenase activity
BW16_RS13220	COG0372	Belongs to the citrate synthase family
BW16_RS13225	COG2707	UPF0756 membrane protein
BW16_RS13230	COG0628	permease
BW16_RS13235	COG3030	protein affecting phage T7 exclusion by the F plasmid
BW16_RS13245	COG0205	6-phosphofructokinase activity
BW16_RS13250	COG0825	malonyl-CoA metabolic process
BW16_RS13255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BW16_RS13260	COG0281	malic enzyme
BW16_RS13265	COG0587	DNA-directed DNA polymerase activity
BW16_RS13285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BW16_RS13300	COG4109	DRTGG domain
BW16_RS13305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BW16_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS13320	COG0165	Argininosuccinate lyase
BW16_RS13325	COG0137	argininosuccinate synthase activity
BW16_RS13330	COG0521	Mo-molybdopterin cofactor biosynthetic process
BW16_RS13335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BW16_RS13340	COG0827	DNA restriction-modification system
BW16_RS13345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BW16_RS13350	COG3874	Sporulation protein YtfJ
BW16_RS13360	COG1714	RDD family
BW16_RS13365	COG0616	signal peptide processing
BW16_RS13370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW16_RS13380	COG3239	Fatty acid desaturase
BW16_RS13385	COG4585	Histidine kinase
BW16_RS13390	COG2197	response regulator
BW16_RS13395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS13400	COG0745	RESPONSE REGULATOR receiver
BW16_RS13405	COG2205	protein histidine kinase activity
BW16_RS13410	COG1136	(ABC) transporter
BW16_RS13415	COG0577	efflux transmembrane transporter activity
BW16_RS13420	COG0402	S-adenosylhomocysteine deaminase activity
BW16_RS13425	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_RS13435	COG1279	arginine transmembrane transporter activity
BW16_RS13440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW16_RS13450	COG0301	tRNA thio-modification
BW16_RS13455	COG1104	cysteine desulfurase activity
BW16_RS13460	COG1114	Component of the transport system for branched-chain amino acids
BW16_RS13465	COG1114	Component of the transport system for branched-chain amino acids
BW16_RS13470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BW16_RS13475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW16_RS13480	COG1309	transcriptional regulator
BW16_RS13485	COG1956	GAF domain-containing protein
BW16_RS13490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW16_RS13500	COG1335	isochorismatase
BW16_RS13510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BW16_RS13515	COG2329	Antibiotic biosynthesis monooxygenase
BW16_RS13520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW16_RS13525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW16_RS13530	COG0454	-acetyltransferase
BW16_RS13535	COG0517	IMP dehydrogenase activity
BW16_RS13540	COG0123	including yeast histone deacetylase and acetoin utilization protein
BW16_RS13545	COG1609	Transcriptional regulator
BW16_RS13555	COG2801	Transposase and inactivated derivatives
BW16_RS13560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BW16_RS13560	COG1605	Chorismate mutase
BW16_RS13565	COG3118	belongs to the thioredoxin family
BW16_RS13570	COG4980	gas vesicle protein
BW16_RS13575	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BW16_RS13580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW16_RS13585	COG1674	ftsk spoiiie
BW16_RS13590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_RS13595	COG4848	Belongs to the UPF0354 family
BW16_RS13600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS13615	COG1363	Peptidase, m42
BW16_RS13620	COG5584	Small secreted protein
BW16_RS13625	COG0281	malic enzyme
BW16_RS13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS13635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW16_RS13645	COG0510	thiamine kinase activity
BW16_RS13650	COG1597	lipid kinase activity
BW16_RS13660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BW16_RS13665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_RS13670	COG3340	Belongs to the peptidase S51 family
BW16_RS13675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW16_RS13680	COG2252	PERMEase
BW16_RS13685	COG1349	DNA-binding transcription factor activity
BW16_RS13690	COG1187	pseudouridine synthase activity
BW16_RS13695	COG2244	polysaccharide biosynthetic process
BW16_RS13700	COG2081	HI0933 family
BW16_RS13710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BW16_RS13715	COG3196	Protein conserved in bacteria
BW16_RS13725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_RS13730	COG5578	integral membrane protein
BW16_RS13735	COG0673	inositol 2-dehydrogenase activity
BW16_RS13740	COG1653	transport
BW16_RS13745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BW16_RS13750	COG4209	transmembrane transport
BW16_RS13755	COG2207	Transcriptional regulator
BW16_RS13760	COG1733	regulation of RNA biosynthetic process
BW16_RS13765	COG2814	Major facilitator Superfamily
BW16_RS13770	COG0656	L-ascorbic acid biosynthetic process
BW16_RS13775	COG1653	transport
BW16_RS13780	COG0395	ABC-type sugar transport system, permease component
BW16_RS13785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_RS13790	COG1073	alpha beta
BW16_RS13795	COG0495	leucyl-tRNA aminoacylation
BW16_RS13805	COG2202	Pas domain
BW16_RS13805	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS13810	COG2433	Pfam Transposase IS66
BW16_RS13815	COG0577	efflux transmembrane transporter activity
BW16_RS13820	COG1136	(ABC) transporter
BW16_RS13830	COG1131	(ABC) transporter
BW16_RS13835	COG1725	Transcriptional regulator
BW16_RS13855	COG1242	4 iron, 4 sulfur cluster binding
BW16_RS13860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BW16_RS13865	COG4326	sporulation control protein
BW16_RS13875	COG2267	carboxylic ester hydrolase activity
BW16_RS13880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BW16_RS13885	COG0367	asparagine synthase
BW16_RS13890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW16_RS13895	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BW16_RS13905	COG1506	peptidase
BW16_RS13910	COG1233	COG1233 Phytoene dehydrogenase and related
BW16_RS13930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BW16_RS13935	COG1116	anion transmembrane transporter activity
BW16_RS13940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BW16_RS13945	COG0494	nUDIX hydrolase
BW16_RS13950	COG2310	stress, protein
BW16_RS13965	COG4824	toxin secretion phage lysis holin
BW16_RS13975	COG0783	Belongs to the Dps family
BW16_RS13990	COG1854	S-ribosylhomocysteine lyase activity
BW16_RS13995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW16_RS14000	COG0288	reversible hydration of carbon dioxide
BW16_RS14005	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW16_RS14005	COG3443	Belongs to the bacterial solute-binding protein 9 family
BW16_RS14015	COG1271	oxidase subunit
BW16_RS14020	COG1294	oxidase, subunit
BW16_RS14030	COG4948	Mandelate Racemase Muconate Lactonizing
BW16_RS14035	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_RS14040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BW16_RS14045	COG0596	Alpha beta hydrolase
BW16_RS14050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BW16_RS14055	COG1169	isochorismate synthase
BW16_RS14060	COG1575	Belongs to the MenA family. Type 1 subfamily
BW16_RS14065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_RS14195	COG3859	Proton-coupled thiamine transporter YuaJ
BW16_RS14200	COG1247	-acetyltransferase
BW16_RS14205	COG3339	Conserved Protein
BW16_RS14210	COG0772	Belongs to the SEDS family
BW16_RS14215	COG0772	Belongs to the SEDS family
BW16_RS14220	COG2268	Band 7 protein
BW16_RS14225	COG1585	Membrane protein implicated in regulation of membrane protease activity
BW16_RS14230	COG2318	DinB family
BW16_RS14235	COG1454	alcohol dehydrogenase
BW16_RS14240	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS14245	COG1510	regulation of RNA biosynthetic process
BW16_RS14260	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS14260	COG5632	N-Acetylmuramoyl-L-alanine amidase
BW16_RS14325	COG3778	Protein conserved in bacteria
BW16_RS14330	COG3299	homolog of phage Mu protein gp47
BW16_RS14335	COG3628	GPW Gp25 family protein
BW16_RS14345	COG4193	domain, Protein
BW16_RS14350	COG1652	LysM domain
BW16_RS14355	COG5280	Phage tail tape measure protein TP901
BW16_RS14355	COG3953	SLT domain
BW16_RS14405	COG4653	Phage capsid family
BW16_RS14410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BW16_RS14420	COG1783	phage Terminase large subunit
BW16_RS14425	COG5484	DNA packaging
BW16_RS14430	COG1595	DNA-templated transcription, initiation
BW16_RS14440	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BW16_RS14455	COG1396	sequence-specific DNA binding
BW16_RS14465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BW16_RS14480	COG0628	permease
BW16_RS14490	COG0673	inositol 2-dehydrogenase activity
BW16_RS14495	COG0693	protein deglycase activity
BW16_RS14500	COG0840	transmembrane signaling receptor activity
BW16_RS14505	COG0840	transmembrane signaling receptor activity
BW16_RS14510	COG0840	transmembrane signaling receptor activity
BW16_RS14515	COG0840	transmembrane signaling receptor activity
BW16_RS14530	COG2070	2-Nitropropane dioxygenase
BW16_RS14535	COG0432	Pfam Uncharacterised protein family UPF0047
BW16_RS14540	COG1253	flavin adenine dinucleotide binding
BW16_RS14545	COG2738	Putative neutral zinc metallopeptidase
BW16_RS14555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BW16_RS14580	COG1979	alcohol dehydrogenase
BW16_RS14585	COG1979	alcohol dehydrogenase
BW16_RS14590	COG2155	Conserved Protein
BW16_RS14595	COG1098	S1 RNA binding domain
BW16_RS14600	COG0436	Aminotransferase
BW16_RS14605	COG1522	sequence-specific DNA binding
BW16_RS14610	COG2267	carboxylic ester hydrolase activity
BW16_RS14620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW16_RS14625	COG2205	protein histidine kinase activity
BW16_RS14635	COG5018	Exonuclease
BW16_RS14640	COG2814	Major facilitator Superfamily
BW16_RS14645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_RS14650	COG3011	Protein conserved in bacteria
BW16_RS14660	COG3290	protein histidine kinase activity
BW16_RS14665	COG4565	transcriptional regulatory protein
BW16_RS14670	COG1744	ABC transporter substrate-binding protein PnrA-like
BW16_RS14675	COG3845	ABC transporter
BW16_RS14680	COG4603	Belongs to the binding-protein-dependent transport system permease family
BW16_RS14685	COG1079	Belongs to the binding-protein-dependent transport system permease family
BW16_RS14690	COG3493	citrate carrier protein
BW16_RS14700	COG2111	Na H antiporter
BW16_RS14700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW16_RS14705	COG2111	Na H antiporter
BW16_RS14710	COG1006	Multisubunit Na H antiporter MnhC subunit
BW16_RS14715	COG0651	ATP synthesis coupled electron transport
BW16_RS14720	COG1863	multisubunit Na H antiporter MnhE subunit
BW16_RS14725	COG2212	antiporter activity
BW16_RS14730	COG1320	monovalent cation:proton antiporter activity
BW16_RS14735	COG2050	protein possibly involved in aromatic compounds catabolism
BW16_RS14740	COG2197	response regulator
BW16_RS14745	COG4585	Histidine kinase
BW16_RS14755	COG0142	geranyltranstransferase activity
BW16_RS14770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BW16_RS14775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BW16_RS14780	COG1335	isochorismatase
BW16_RS14785	COG5506	Protein of unknown function (DUF1694)
BW16_RS14805	COG0628	permease
BW16_RS14820	COG1418	mRNA catabolic process
BW16_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS14835	COG1511	domain protein
BW16_RS14840	COG1674	ftsk spoiiie
BW16_RS14840	COG0433	COG0433 Predicted ATPase
BW16_RS14845	COG4499	WXG100 protein secretion system (Wss), protein YukC
BW16_RS14850	COG5417	Belongs to the EsaB family
BW16_RS14855	COG4842	Belongs to the WXG100 family
BW16_RS14860	COG2508	Transcriptional regulator
BW16_RS14860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BW16_RS14865	COG0686	Belongs to the AlaDH PNT family
BW16_RS14870	COG1268	BioY protein
BW16_RS14875	COG2056	Na+-H+ antiporter family
BW16_RS14880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BW16_RS14885	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BW16_RS14890	COG3584	3D domain protein
BW16_RS14900	COG1252	NADH dehydrogenase
BW16_RS14905	COG0492	ferredoxin-NADP+ reductase activity
BW16_RS14920	COG0316	Belongs to the HesB IscA family
BW16_RS14925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BW16_RS14930	COG4844	belongs to the
BW16_RS14935	COG1252	NADH dehydrogenase
BW16_RS14945	COG4837	Protein of unknown function (DUF1462)
BW16_RS14950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BW16_RS14955	COG0823	Involved in the tonB-independent uptake of proteins
BW16_RS14955	COG4946	Tricorn protease homolog
BW16_RS14955	COG1506	peptidase
BW16_RS14960	COG0083	homoserine kinase activity
BW16_RS14965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW16_RS14970	COG0460	homoserine dehydrogenase
BW16_RS14975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_RS14980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_RS14985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BW16_RS14990	COG0647	UMP catabolic process
BW16_RS14995	COG2445	Protein of unknown function DUF86
BW16_RS15000	COG4470	Protein conserved in bacteria
BW16_RS15010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BW16_RS15015	COG0739	heme binding
BW16_RS15035	COG3377	Domain of unknown function (DUF1805)
BW16_RS15040	COG0737	Belongs to the 5'-nucleotidase family
BW16_RS15045	COG1801	Protein of unknown function DUF72
BW16_RS15050	COG2508	Transcriptional regulator
BW16_RS15055	COG2140	Oxalate decarboxylase
BW16_RS15060	COG2814	Major facilitator Superfamily
BW16_RS15065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BW16_RS15070	COG2356	endonuclease I
BW16_RS15085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS15110	COG0561	phosphatase activity
BW16_RS15120	COG5002	protein histidine kinase activity
BW16_RS15120	COG0642	Histidine kinase
BW16_RS15125	COG0745	RESPONSE REGULATOR receiver
BW16_RS15130	COG2311	Membrane
BW16_RS15140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_RS15145	COG1090	epimerase
BW16_RS15150	COG1309	transcriptional regulator
BW16_RS15165	COG0719	Fe-S assembly protein
BW16_RS15170	COG0822	iron-sulfur transferase activity
BW16_RS15175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW16_RS15180	COG0719	Fe-S assembly protein
BW16_RS15185	COG0396	ATPase activity
BW16_RS15195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BW16_RS15200	COG1464	Belongs to the NlpA lipoprotein family
BW16_RS15205	COG2011	ABC-type metal ion transport system permease component
BW16_RS15210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW16_RS15220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_RS15225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BW16_RS15235	COG0509	glycine decarboxylation via glycine cleavage system
BW16_RS15240	COG1393	Belongs to the ArsC family
BW16_RS15245	COG1960	acyl-CoA dehydrogenase activity
BW16_RS15250	COG0183	Belongs to the thiolase family
BW16_RS15255	COG1024	Enoyl-CoA hydratase
BW16_RS15255	COG1250	3-hydroxyacyl-CoA dehydrogenase
BW16_RS15265	COG5577	PFAM Coat F domain
BW16_RS15275	COG1120	ATPase activity
BW16_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS15290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_RS15295	COG0745	RESPONSE REGULATOR receiver
BW16_RS15300	COG2770	Histidine kinase
BW16_RS15300	COG2205	protein histidine kinase activity
BW16_RS15305	COG1309	transcriptional regulator
BW16_RS15315	COG0114	fumarate hydratase activity
BW16_RS15320	COG0697	spore germination
BW16_RS15325	COG0814	amino acid
BW16_RS15340	COG2197	response regulator
BW16_RS15345	COG4585	Histidine kinase
BW16_RS15350	COG4758	membrane
BW16_RS15360	COG1842	Phage shock protein A
BW16_RS15365	COG4758	membrane
BW16_RS15370	COG2096	Adenosyltransferase
BW16_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS15380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BW16_RS15390	COG3604	Transcriptional regulator
BW16_RS15405	COG1454	alcohol dehydrogenase
BW16_RS15410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW16_RS15415	COG1120	ATPase activity
BW16_RS15420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS15435	COG2721	sulfolactate sulfo-lyase activity
BW16_RS15440	COG0246	Mannitol dehydrogenase
BW16_RS15445	COG1609	Transcriptional regulator
BW16_RS15450	COG1904	glucuronate isomerase
BW16_RS15455	COG2205	protein histidine kinase activity
BW16_RS15460	COG0745	RESPONSE REGULATOR receiver
BW16_RS15465	COG1120	ATPase activity
BW16_RS15470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS15485	COG0531	amino acid
BW16_RS15500	COG1988	membrane-bound metal-dependent
BW16_RS15505	COG1368	sulfuric ester hydrolase activity
BW16_RS15510	COG0725	ABC transporter, periplasmic molybdate-binding protein
BW16_RS15515	COG4149	molybdate abc transporter
BW16_RS15520	COG0656	L-ascorbic acid biosynthetic process
BW16_RS15525	COG1940	carbohydrate kinase activity
BW16_RS15530	COG0025	NhaP-type Na H and K H
BW16_RS15535	COG2860	membrane
BW16_RS15540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BW16_RS15545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW16_RS15550	COG2217	Heavy metal translocating P-type atpase
BW16_RS15555	COG1121	(ABC) transporter
BW16_RS15560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW16_RS15565	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW16_RS15575	COG3226	Transcriptional regulator
BW16_RS15580	COG0784	Response regulator, receiver
BW16_RS15585	COG4191	Histidine kinase
BW16_RS15590	COG1027	Aspartate ammonia-lyase
BW16_RS15600	COG2217	Heavy metal translocating P-type atpase
BW16_RS15605	COG2608	mercury ion transmembrane transporter activity
BW16_RS15610	COG1937	Protein conserved in bacteria
BW16_RS15630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_RS15630	COG0463	Glycosyl transferase, family 2
BW16_RS15635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW16_RS15640	COG0557	exoribonuclease II activity
BW16_RS15645	COG1647	Serine aminopeptidase, S33
BW16_RS15650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW16_RS15655	COG2002	toxin-antitoxin pair type II binding
BW16_RS15660	COG1476	TRANSCRIPTIONal
BW16_RS15665	COG1396	sequence-specific DNA binding
BW16_RS15670	COG1396	sequence-specific DNA binding
BW16_RS15675	COG1733	regulation of RNA biosynthetic process
BW16_RS15680	COG1174	glycine betaine transport
BW16_RS15685	COG1732	Glycine betaine
BW16_RS15690	COG1174	glycine betaine transport
BW16_RS15695	COG1125	glycine betaine transport
BW16_RS15695	COG0517	IMP dehydrogenase activity
BW16_RS15700	COG1510	regulation of RNA biosynthetic process
BW16_RS15705	COG2095	MarC family integral membrane protein
BW16_RS15715	COG0456	acetyltransferase
BW16_RS15735	COG1131	(ABC) transporter
BW16_RS15745	COG0148	phosphopyruvate hydratase activity
BW16_RS15750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BW16_RS15755	COG0149	triose-phosphate isomerase activity
BW16_RS15760	COG0126	phosphoglycerate kinase activity
BW16_RS15765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW16_RS15770	COG2390	Transcriptional regulator
BW16_RS15775	COG0833	amino acid
BW16_RS15780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW16_RS15785	COG3829	transcription factor binding
BW16_RS15790	COG2186	Transcriptional regulator
BW16_RS15795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BW16_RS15805	COG0534	Mate efflux family protein
BW16_RS15810	COG4608	Belongs to the ABC transporter superfamily
BW16_RS15815	COG0444	Belongs to the ABC transporter superfamily
BW16_RS15820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_RS15825	COG0601	transmembrane transport
BW16_RS15830	COG0747	negative chemotaxis
BW16_RS15835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_RS15840	COG0110	maltose O-acetyltransferase activity
BW16_RS15845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BW16_RS15850	COG2244	polysaccharide biosynthetic process
BW16_RS15855	COG5039	Polysaccharide pyruvyl transferase
BW16_RS15860	COG1216	Glycosyl transferase, family 2
BW16_RS15870	COG0438	transferase activity, transferring glycosyl groups
BW16_RS15875	COG1215	transferase activity, transferring glycosyl groups
BW16_RS15885	COG1086	Polysaccharide biosynthesis protein
BW16_RS15890	COG0489	protein tyrosine kinase activity
BW16_RS15895	COG3944	biosynthesis protein
BW16_RS15900	COG1396	sequence-specific DNA binding
BW16_RS15910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS15925	COG0726	polysaccharide deacetylase
BW16_RS15930	COG0488	(ABC) transporter
BW16_RS15935	COG4608	Belongs to the ABC transporter superfamily
BW16_RS15950	COG0601	transmembrane transport
BW16_RS15955	COG0747	negative chemotaxis
BW16_RS15960	COG1819	glycosyl
BW16_RS15965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS15980	COG0740	serine-type endopeptidase activity
BW16_RS15985	COG1611	Belongs to the LOG family
BW16_RS15990	COG1694	Mazg nucleotide pyrophosphohydrolase
BW16_RS15995	COG0659	secondary active sulfate transmembrane transporter activity
BW16_RS16000	COG0288	reversible hydration of carbon dioxide
BW16_RS16005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_RS16015	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BW16_RS16020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS16025	COG1481	regulation of sporulation
BW16_RS16030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BW16_RS16035	COG1660	Displays ATPase and GTPase activities
BW16_RS16040	COG1051	belongs to the nudix hydrolase family
BW16_RS16045	COG0492	ferredoxin-NADP+ reductase activity
BW16_RS16050	COG3883	PFAM NLP P60 protein
BW16_RS16050	COG0791	NLP P60 protein
BW16_RS16055	COG0457	Tetratricopeptide repeat
BW16_RS16060	COG0140	phosphoribosyl-ATP diphosphatase activity
BW16_RS16060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BW16_RS16065	COG0107	imidazoleglycerol-phosphate synthase activity
BW16_RS16070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BW16_RS16075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BW16_RS16080	COG0131	Imidazoleglycerol-phosphate dehydratase
BW16_RS16085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BW16_RS16090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BW16_RS16095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BW16_RS16100	COG4990	cell redox homeostasis
BW16_RS16105	COG2910	NAD(P)H-binding
BW16_RS16110	COG1959	2 iron, 2 sulfur cluster binding
BW16_RS16115	COG0110	maltose O-acetyltransferase activity
BW16_RS16120	COG0546	phosphoglycolate phosphatase activity
BW16_RS16125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BW16_RS16135	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BW16_RS16140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BW16_RS16145	COG0363	glucosamine-6-phosphate deaminase activity
BW16_RS16150	COG2188	Transcriptional regulator
BW16_RS16155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BW16_RS16160	COG1950	PFAM Membrane protein of
BW16_RS16165	COG1983	PspC domain protein
BW16_RS16170	COG3595	metallopeptidase activity
BW16_RS16185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW16_RS16195	COG4897	Protein conserved in bacteria
BW16_RS16200	COG0574	Belongs to the PEP-utilizing enzyme family
BW16_RS16200	COG3848	Pyruvate phosphate dikinase
BW16_RS16205	COG1309	transcriptional regulator
BW16_RS16210	COG2814	Major facilitator Superfamily
BW16_RS16220	COG0745	RESPONSE REGULATOR receiver
BW16_RS16225	COG5002	protein histidine kinase activity
BW16_RS16230	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BW16_RS16235	COG0463	Glycosyl transferase, family 2
BW16_RS16240	COG1113	amino acid transport
BW16_RS16245	COG0778	Nitroreductase
BW16_RS16250	COG1733	regulation of RNA biosynthetic process
BW16_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_RS16265	COG3409	Peptidoglycan-binding domain 1 protein
BW16_RS16265	COG0793	Belongs to the peptidase S41A family
BW16_RS16270	COG0730	response to heat
BW16_RS16275	COG3883	PFAM NLP P60 protein
BW16_RS16275	COG0791	NLP P60 protein
BW16_RS16280	COG2177	Part of the ABC transporter FtsEX involved in
BW16_RS16285	COG2884	Cell division ATP-binding protein ftsE
BW16_RS16290	COG2010	Cytochrome c
BW16_RS16295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_RS16310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW16_RS16315	COG0653	protein targeting
BW16_RS16320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW16_RS16325	COG0840	transmembrane signaling receptor activity
BW16_RS16340	COG1516	flagellar protein fliS
BW16_RS16345	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BW16_RS16350	COG1334	flagellar protein FlaG
BW16_RS16355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BW16_RS16360	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BW16_RS16370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_RS16375	COG4786	Flagellar basal body rod
BW16_RS16375	COG1256	bacterial-type flagellum assembly
BW16_RS16380	COG3418	PFAM FlgN family protein
BW16_RS16395	COG1040	competence protein
BW16_RS16405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BW16_RS16410	COG1307	EDD domain protein, DegV family
BW16_RS16415	COG2197	response regulator
BW16_RS16420	COG4585	Histidine kinase
BW16_RS16425	COG1739	Uncharacterized protein family UPF0029
BW16_RS16430	COG1316	TRANSCRIPTIONal
BW16_RS16435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW16_RS16440	COG0438	transferase activity, transferring glycosyl groups
BW16_RS16445	COG1215	transferase activity, transferring glycosyl groups
BW16_RS16450	COG3206	protein involved in exopolysaccharide biosynthesis
BW16_RS16455	COG3307	-O-antigen
BW16_RS16460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_RS16465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW16_RS16470	COG0297	glycogen (starch) synthase activity
BW16_RS16470	COG0438	transferase activity, transferring glycosyl groups
BW16_RS16475	COG2244	polysaccharide biosynthetic process
BW16_RS16490	COG2247	cell wall binding repeat
BW16_RS16490	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_RS16495	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_RS16495	COG2247	cell wall binding repeat
BW16_RS16500	COG2385	sporulation resulting in formation of a cellular spore
BW16_RS16500	COG2247	cell wall binding repeat
BW16_RS16510	COG1316	TRANSCRIPTIONal
BW16_RS16515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BW16_RS16520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BW16_RS16525	COG1134	teichoic acid transport
BW16_RS16530	COG1682	transport, permease protein
BW16_RS16535	COG1215	transferase activity, transferring glycosyl groups
BW16_RS16560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_RS16570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BW16_RS16575	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BW16_RS16580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_RS16585	COG4193	domain, Protein
BW16_RS16590	COG1482	cell wall glycoprotein biosynthetic process
BW16_RS16600	COG1175	transmembrane transport
BW16_RS16605	COG1653	transport
BW16_RS16610	COG2197	response regulator
BW16_RS16615	COG2972	Histidine kinase
BW16_RS16625	COG0454	-acetyltransferase
BW16_RS16630	COG0800	Aldolase
BW16_RS16635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW16_RS16640	COG1609	Transcriptional regulator
BW16_RS16645	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BW16_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS16655	COG0697	spore germination
BW16_RS16660	COG0814	amino acid
BW16_RS16675	COG2814	Major facilitator Superfamily
BW16_RS16680	COG1316	TRANSCRIPTIONal
BW16_RS16685	COG0561	phosphatase activity
BW16_RS16690	COG0791	NLP P60 protein
BW16_RS16695	COG2843	Capsule synthesis protein
BW16_RS16705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW16_RS16710	COG0697	spore germination
BW16_RS16725	COG1609	Transcriptional regulator
BW16_RS16730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW16_RS16735	COG1869	D-ribose catabolic process
BW16_RS16740	COG1129	ABC transporter
BW16_RS16745	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW16_RS16750	COG1879	ABC-type sugar transport system periplasmic component
BW16_RS16755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BW16_RS16760	COG0583	DNA-binding transcription factor activity
BW16_RS16765	COG0028	Belongs to the TPP enzyme family
BW16_RS16770	COG3527	Alpha-acetolactate decarboxylase
BW16_RS16775	COG1522	sequence-specific DNA binding
BW16_RS16780	COG2059	Chromate
BW16_RS16785	COG2059	Chromate
BW16_RS16790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW16_RS16795	COG4715	Zinc finger, swim domain protein
BW16_RS16800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW16_RS16805	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_RS16805	COG2202	Pas domain
BW16_RS16810	COG0561	phosphatase activity
BW16_RS16825	COG1970	mechanosensitive ion channel activity
BW16_RS16830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BW16_RS16835	COG0457	Tetratricopeptide repeat
BW16_RS16840	COG4786	Flagellar basal body rod
BW16_RS16845	COG4786	Flagellar basal body rod
BW16_RS16850	COG1077	Cell shape determining protein MreB Mrl
BW16_RS16855	COG1609	Transcriptional regulator
BW16_RS16860	COG1846	Transcriptional regulator
BW16_RS16865	COG2814	Major facilitator Superfamily
BW16_RS16870	COG0671	phosphoesterase, PA-phosphatase related
BW16_RS16875	COG0477	Major facilitator Superfamily
BW16_RS16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS16885	COG0765	amino acid transport
BW16_RS16890	COG1126	abc transporter atp-binding protein
BW16_RS16895	COG0004	ammonium transporteR
BW16_RS16900	COG0347	Belongs to the P(II) protein family
BW16_RS16905	COG0739	heme binding
BW16_RS16910	COG1247	-acetyltransferase
BW16_RS16920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW16_RS16925	COG0523	cobalamin synthesis protein
BW16_RS16930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW16_RS16935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BW16_RS16940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BW16_RS16945	COG2223	nitrite transmembrane transporter activity
BW16_RS16955	COG2304	oxidoreductase activity
BW16_RS16960	COG2304	oxidoreductase activity
BW16_RS16965	COG2385	sporulation resulting in formation of a cellular spore
BW16_RS16970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW16_RS16980	COG4836	Membrane
BW16_RS16990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW16_RS16995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW16_RS17000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BW16_RS17005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW16_RS17010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW16_RS17015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW16_RS17020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW16_RS17025	COG0356	it plays a direct role in the translocation of protons across the membrane
BW16_RS17035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BW16_RS17040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BW16_RS17045	COG4475	Protein of unknown function (DUF436)
BW16_RS17050	COG0698	ribose 5-phosphate isomerase
BW16_RS17055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_RS17060	COG1971	Probably functions as a manganese efflux pump
BW16_RS17065	COG0009	L-threonylcarbamoyladenylate synthase
BW16_RS17070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BW16_RS17085	COG2890	protein-(glutamine-N5) methyltransferase activity
BW16_RS17090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW16_RS17095	COG0789	Transcriptional regulator
BW16_RS17100	COG0679	Auxin Efflux Carrier
BW16_RS17105	COG0281	malic enzyme
BW16_RS17110	COG1435	thymidine kinase activity
BW16_RS17115	COG0254	rRNA binding
BW16_RS17120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BW16_RS17125	COG1494	fructose-1,6-bisphosphatase
BW16_RS17130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW16_RS17135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW16_RS17140	COG0191	fructose-bisphosphate aldolase activity
BW16_RS17145	COG2204	response regulator
BW16_RS17150	COG4821	SIS domain
BW16_RS17155	COG0504	CTP synthase activity
BW16_RS17160	COG3343	RNA polymerase activity
BW16_RS17175	COG1960	acyl-CoA dehydrogenase activity
BW16_RS17180	COG1960	acyl-CoA dehydrogenase activity
BW16_RS17185	COG1250	3-hydroxyacyl-CoA dehydrogenase
BW16_RS17190	COG0183	Belongs to the thiolase family
BW16_RS17195	COG0247	lactate metabolic process
BW16_RS17195	COG2181	nitrate reductase activity
BW16_RS17200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_RS17205	COG4294	response to UV
BW16_RS17215	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_RS17225	COG1132	(ABC) transporter
BW16_RS17230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_RS17235	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_RS17245	COG0018	arginyl-trna synthetase
BW16_RS17250	COG4506	Protein conserved in bacteria
BW16_RS17260	COG0010	Belongs to the arginase family
BW16_RS17265	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BW16_RS17270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_RS17280	COG1994	Peptidase M50
BW16_RS17285	COG1942	4-Oxalocrotonate Tautomerase
BW16_RS17295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS17300	COG0583	DNA-binding transcription factor activity
BW16_RS17305	COG0431	NADPH-dependent FMN reductase
BW16_RS17310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS17315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BW16_RS17320	COG0454	-acetyltransferase
BW16_RS17325	COG0765	amino acid transport
BW16_RS17335	COG0765	amino acid transport
BW16_RS17340	COG1126	abc transporter atp-binding protein
BW16_RS17345	COG3465	dGTPase activity
BW16_RS17350	COG1078	dGTPase activity
BW16_RS17355	COG4844	belongs to the
BW16_RS17405	COG5444	nuclease activity
BW16_RS17435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BW16_RS17445	COG0280	phosphate acetyltransferase
BW16_RS17455	COG2814	Major facilitator Superfamily
BW16_RS17460	COG1522	sequence-specific DNA binding
BW16_RS17465	COG2814	Major facilitator Superfamily
BW16_RS17470	COG0077	Prephenate dehydratase
BW16_RS17475	COG1917	Cupin 2, conserved barrel domain protein
BW16_RS17480	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS17485	COG0151	Belongs to the GarS family
BW16_RS17490	COG0436	Aminotransferase
BW16_RS17495	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_RS17500	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BW16_RS17505	COG1091	dTDP-4-dehydrorhamnose reductase activity
BW16_RS17510	COG1088	dTDP-glucose 4,6-dehydratase activity
BW16_RS17515	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BW16_RS17520	COG3980	spore coat polysaccharide biosynthesis protein
BW16_RS17525	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BW16_RS17530	COG2089	acid synthase
BW16_RS17535	COG0456	acetyltransferase
BW16_RS17540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_RS17545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_RS17550	COG0463	Glycosyl transferase, family 2
BW16_RS17570	COG2363	Small membrane protein
BW16_RS17575	COG2233	PERMEase
BW16_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
BW16_RS17590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BW16_RS17595	COG1216	Glycosyl transferase, family 2
BW16_RS17605	COG0351	phosphomethylpyrimidine kinase
BW16_RS17620	COG1621	beta-fructofuranosidase activity
BW16_RS17625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS17625	COG1263	PTS System
BW16_RS17630	COG3711	transcriptional antiterminator
BW16_RS17640	COG1404	Belongs to the peptidase S8 family
BW16_RS17650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_RS17655	COG0778	Nitroreductase
BW16_RS17660	COG0772	Belongs to the SEDS family
BW16_RS17670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BW16_RS17675	COG1845	cytochrome c oxidase, subunit III
BW16_RS17680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW16_RS17685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW16_RS17695	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BW16_RS17700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BW16_RS17705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW16_RS17720	COG2246	polysaccharide biosynthetic process
BW16_RS17740	COG3162	membrane
BW16_RS17745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_RS17760	COG0352	thiamine-phosphate diphosphorylase activity
BW16_RS17765	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BW16_RS17770	COG0583	DNA-binding transcription factor activity
BW16_RS17775	COG1380	Effector of murein hydrolase LrgA
BW16_RS17780	COG1346	cytolysis
BW16_RS17785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BW16_RS17790	COG0346	lactoylglutathione lyase activity
BW16_RS17800	COG0765	amino acid transport
BW16_RS17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_RS17810	COG0457	Tetratricopeptide repeat
BW16_RS17815	COG2357	RelA SpoT domain protein
BW16_RS17820	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW16_RS17825	COG1129	ABC transporter
BW16_RS17835	COG3420	alginic acid biosynthetic process
BW16_RS17840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_RS17855	COG1486	melibiose metabolic process
BW16_RS17860	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_RS17865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS17870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS17875	COG3711	transcriptional antiterminator
BW16_RS17875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS17890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_RS17905	COG1595	DNA-templated transcription, initiation
BW16_RS17915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW16_RS17920	COG4988	ABC transporter
BW16_RS17925	COG1294	oxidase, subunit
BW16_RS17930	COG1271	oxidase subunit
BW16_RS17935	COG1120	ATPase activity
BW16_RS17940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_RS17945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BW16_RS17950	COG4509	Sortase family
BW16_RS17975	COG5386	Cell surface protein
BW16_RS17980	COG5386	Cell surface protein
BW16_RS17985	COG1733	regulation of RNA biosynthetic process
BW16_RS17990	COG2514	catechol 2,3-dioxygenase activity
BW16_RS17995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_RS17995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_RS18000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_RS18000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_RS18010	COG0726	polysaccharide deacetylase
BW16_RS18015	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_RS18020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS18025	COG2723	6-phospho-beta-galactosidase activity
BW16_RS18030	COG1312	Catalyzes the dehydration of D-mannonate
BW16_RS18035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_RS18040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_RS18040	COG3711	transcriptional antiterminator
BW16_RS18065	COG1757	Na H antiporter
BW16_RS18070	COG1027	Aspartate ammonia-lyase
BW16_RS18075	COG0252	asparaginase activity
BW16_RS18080	COG1396	sequence-specific DNA binding
BW16_RS18105	COG4842	Belongs to the WXG100 family
BW16_RS18110	COG2195	Cleaves the N-terminal amino acid of tripeptides
BW16_RS18120	COG2801	Transposase and inactivated derivatives
BW16_RS18135	COG1737	Transcriptional regulator
BW16_RS18140	COG2084	Dehydrogenase
BW16_RS18150	COG2610	gluconate transmembrane transporter activity
BW16_RS18155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BW16_RS18180	COG2723	6-phospho-beta-galactosidase activity
BW16_RS18185	COG2190	(PTS) system
BW16_RS18185	COG1263	PTS System
BW16_RS18185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS18190	COG3711	transcriptional antiterminator
BW16_RS18195	COG3878	Protein conserved in bacteria
BW16_RS18205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_RS18210	COG1122	ATPase activity
BW16_RS18215	COG4721	ABC-type cobalt transport system, permease component
BW16_RS18220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW16_RS18250	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BW16_RS18255	COG0778	Nitroreductase
BW16_RS18260	COG1846	Transcriptional regulator
BW16_RS18265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BW16_RS18270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BW16_RS18275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW16_RS18280	COG2390	Transcriptional regulator
BW16_RS18290	COG2755	lipolytic protein G-D-S-L family
BW16_RS18290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BW16_RS18295	COG0477	Major facilitator Superfamily
BW16_RS18300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW16_RS18305	COG2226	methyltransferase
BW16_RS18315	COG0561	phosphatase activity
BW16_RS18320	COG0789	Transcriptional regulator
BW16_RS18325	COG0673	inositol 2-dehydrogenase activity
BW16_RS18330	COG2801	Transposase and inactivated derivatives
BW16_RS18340	COG0840	transmembrane signaling receptor activity
BW16_RS18345	COG1113	amino acid transport
BW16_RS18350	COG4335	DNA alkylation repair
BW16_RS18360	COG1070	Carbohydrate kinase
BW16_RS18365	COG1737	Transcriptional regulator
BW16_RS18410	COG0583	DNA-binding transcription factor activity
BW16_RS18415	COG1609	Transcriptional regulator
BW16_RS18420	COG2182	Extracellular solute-binding protein
BW16_RS18425	COG1175	transmembrane transport
BW16_RS18430	COG3833	ABC-type maltose transport systems, permease component
BW16_RS18440	COG1874	Beta-galactosidase
BW16_RS18475	COG2851	Citrate transporter
BW16_RS18485	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BW16_RS18490	COG1131	(ABC) transporter
BW16_RS18500	COG2824	Alkylphosphonate utilization operon protein PhnA
BW16_RS18505	COG1929	Belongs to the glycerate kinase type-1 family
BW16_RS18510	COG2610	gluconate transmembrane transporter activity
BW16_RS18515	COG3835	regulator
BW16_RS18520	COG1309	transcriptional regulator
BW16_RS18525	COG2814	Major facilitator Superfamily
BW16_RS18535	COG1136	(ABC) transporter
BW16_RS18545	COG0457	Tetratricopeptide repeat
BW16_RS18550	COG3711	transcriptional antiterminator
BW16_RS18555	COG2723	6-phospho-beta-galactosidase activity
BW16_RS18560	COG1263	PTS System
BW16_RS18560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS18560	COG2190	(PTS) system
BW16_RS18585	COG0494	nUDIX hydrolase
BW16_RS18605	COG1113	amino acid transport
BW16_RS18610	COG1609	Transcriptional regulator
BW16_RS18615	COG2814	Major facilitator Superfamily
BW16_RS18620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW16_RS18625	COG2814	Major facilitator Superfamily
BW16_RS18630	COG2723	6-phospho-beta-galactosidase activity
BW16_RS18640	COG1263	PTS System
BW16_RS18640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS18640	COG2190	(PTS) system
BW16_RS18660	COG5444	nuclease activity
BW16_RS18675	COG2723	6-phospho-beta-galactosidase activity
BW16_RS18680	COG2190	(PTS) system
BW16_RS18680	COG1263	PTS System
BW16_RS18680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_RS18685	COG2188	Transcriptional regulator
BW16_RS18700	COG0384	phenazine biosynthesis protein PhzF
BW16_RS18705	COG0583	DNA-binding transcription factor activity
BW16_RS18725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BW16_RS18740	COG5002	protein histidine kinase activity
BW16_RS18740	COG3850	Histidine kinase
BW16_RS18750	COG2409	Drug exporters of the RND superfamily
BW16_RS18755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_RS18765	COG1078	dGTPase activity
BW16_RS18770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BW16_RS18775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_RS18785	COG4720	Psort location CytoplasmicMembrane, score
BW16_RS18805	COG0456	acetyltransferase
BW16_RS18810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_RS18815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BW16_RS18820	COG4853	Protein conserved in bacteria
BW16_RS18825	COG4863	YycH protein
BW16_RS18830	COG5002	protein histidine kinase activity
BW16_RS18835	COG0745	RESPONSE REGULATOR receiver
BW16_RS18860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BW16_RS18870	COG2311	Membrane
BW16_RS18875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW16_RS18880	COG1309	transcriptional regulator
BW16_RS18885	COG2124	cytochrome p450
BW16_RS18890	COG0346	lactoylglutathione lyase activity
BW16_RS18895	COG0305	Participates in initiation and elongation during chromosome replication
BW16_RS18915	COG2819	hydrolase of the alpha beta superfamily
BW16_RS18920	COG2207	Transcriptional regulator
BW16_RS18920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS18925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_RS18930	COG2819	hydrolase of the alpha beta superfamily
BW16_RS18935	COG2807	transmembrane transport
BW16_RS18940	COG0359	binds to the 23S rRNA
BW16_RS18945	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BW16_RS18950	COG4241	membrane
BW16_RS18955	COG1227	inorganic diphosphatase activity
BW16_RS18965	COG1595	DNA-templated transcription, initiation
BW16_RS18975	COG0753	catalase activity
BW16_RS18980	COG0655	NAD(P)H dehydrogenase (quinone) activity
BW16_RS18985	COG0400	carboxylic ester hydrolase activity
BW16_RS18990	COG0346	lactoylglutathione lyase activity
BW16_RS18995	COG1174	glycine betaine transport
BW16_RS19000	COG1125	glycine betaine transport
BW16_RS19000	COG0517	IMP dehydrogenase activity
BW16_RS19005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW16_RS19010	COG0629	single-stranded DNA binding
BW16_RS19015	COG0360	Binds together with S18 to 16S ribosomal RNA
BW16_RS19020	COG0012	GTP binding
BW16_RS19025	COG4481	Protein conserved in bacteria
BW16_RS19040	COG3949	Membrane
BW16_RS19050	COG1475	DNA binding
BW16_RS19055	COG1192	Involved in chromosome partitioning
BW16_RS19065	COG1475	DNA binding
BW16_RS19070	COG0357	Ribosomal RNA small subunit methyltransferase G
BW16_RS19075	COG0445	tRNA wobble uridine modification
BW16_RS19080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BW16_RS19085	COG1847	R3H domain protein
BW16_RS19090	COG0706	membrane insertase activity
BW16_RS19095	COG0594	ribonuclease P activity
BW16_RS19115	COG0328	RNA-DNA hybrid ribonuclease activity