locus-tag	class	description
ID12_RS00010	COG3859	Proton-coupled thiamine transporter YuaJ
ID12_RS00015	COG1247	-acetyltransferase
ID12_RS00020	COG3339	Conserved Protein
ID12_RS00025	COG0772	Belongs to the SEDS family
ID12_RS00030	COG0772	Belongs to the SEDS family
ID12_RS00035	COG2268	Band 7 protein
ID12_RS00040	COG1585	Membrane protein implicated in regulation of membrane protease activity
ID12_RS00045	COG2318	DinB family
ID12_RS00050	COG1454	alcohol dehydrogenase
ID12_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS00060	COG1510	regulation of RNA biosynthetic process
ID12_RS00075	COG5632	N-Acetylmuramoyl-L-alanine amidase
ID12_RS00075	COG3409	Peptidoglycan-binding domain 1 protein
ID12_RS00130	COG3778	Protein conserved in bacteria
ID12_RS00135	COG3299	homolog of phage Mu protein gp47
ID12_RS00140	COG3628	GPW Gp25 family protein
ID12_RS00150	COG4193	domain, Protein
ID12_RS00155	COG1652	LysM domain
ID12_RS00160	COG3953	SLT domain
ID12_RS00160	COG5280	Phage tail tape measure protein TP901
ID12_RS00160	COG3953	SLT domain
ID12_RS00160	COG5280	Phage tail tape measure protein TP901
ID12_RS00210	COG4653	Phage capsid family
ID12_RS00215	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ID12_RS00220	COG5518	Phage portal protein
ID12_RS00225	COG1783	phage Terminase large subunit
ID12_RS00230	COG5484	DNA packaging
ID12_RS00235	COG1595	DNA-templated transcription, initiation
ID12_RS00245	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ID12_RS00260	COG1396	sequence-specific DNA binding
ID12_RS00270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ID12_RS00285	COG0628	permease
ID12_RS00295	COG0673	inositol 2-dehydrogenase activity
ID12_RS00300	COG0693	protein deglycase activity
ID12_RS00305	COG0840	transmembrane signaling receptor activity
ID12_RS00310	COG0840	transmembrane signaling receptor activity
ID12_RS00315	COG0840	transmembrane signaling receptor activity
ID12_RS00320	COG0840	transmembrane signaling receptor activity
ID12_RS00335	COG2070	2-Nitropropane dioxygenase
ID12_RS00340	COG0432	Pfam Uncharacterised protein family UPF0047
ID12_RS00345	COG1253	flavin adenine dinucleotide binding
ID12_RS00350	COG2738	Putative neutral zinc metallopeptidase
ID12_RS00360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ID12_RS00375	COG0166	Belongs to the GPI family
ID12_RS00380	COG1979	alcohol dehydrogenase
ID12_RS00385	COG1979	alcohol dehydrogenase
ID12_RS00390	COG2155	Conserved Protein
ID12_RS00395	COG1098	S1 RNA binding domain
ID12_RS00400	COG0436	Aminotransferase
ID12_RS00405	COG1522	sequence-specific DNA binding
ID12_RS00410	COG2267	carboxylic ester hydrolase activity
ID12_RS00420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ID12_RS00425	COG2205	protein histidine kinase activity
ID12_RS00435	COG5018	Exonuclease
ID12_RS00440	COG2814	Major facilitator Superfamily
ID12_RS00445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_RS00450	COG3011	Protein conserved in bacteria
ID12_RS00460	COG3290	protein histidine kinase activity
ID12_RS00465	COG4565	transcriptional regulatory protein
ID12_RS00470	COG1744	ABC transporter substrate-binding protein PnrA-like
ID12_RS00475	COG3845	ABC transporter
ID12_RS00480	COG4603	Belongs to the binding-protein-dependent transport system permease family
ID12_RS00485	COG1079	Belongs to the binding-protein-dependent transport system permease family
ID12_RS00490	COG3493	citrate carrier protein
ID12_RS00505	COG2111	Na H antiporter
ID12_RS00505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ID12_RS00510	COG2111	Na H antiporter
ID12_RS00515	COG1006	Multisubunit Na H antiporter MnhC subunit
ID12_RS00520	COG0651	ATP synthesis coupled electron transport
ID12_RS00525	COG1863	multisubunit Na H antiporter MnhE subunit
ID12_RS00530	COG2212	antiporter activity
ID12_RS00535	COG1320	monovalent cation:proton antiporter activity
ID12_RS00540	COG2050	protein possibly involved in aromatic compounds catabolism
ID12_RS00545	COG2197	response regulator
ID12_RS00550	COG4585	Histidine kinase
ID12_RS00560	COG0142	geranyltranstransferase activity
ID12_RS00575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ID12_RS00580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ID12_RS00585	COG1335	isochorismatase
ID12_RS00590	COG5506	Protein of unknown function (DUF1694)
ID12_RS00610	COG0628	permease
ID12_RS00625	COG1418	mRNA catabolic process
ID12_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS00640	COG1511	domain protein
ID12_RS00645	COG0433	COG0433 Predicted ATPase
ID12_RS00645	COG1674	ftsk spoiiie
ID12_RS00650	COG4499	WXG100 protein secretion system (Wss), protein YukC
ID12_RS00655	COG5417	Belongs to the EsaB family
ID12_RS00660	COG4842	Belongs to the WXG100 family
ID12_RS00665	COG2508	Transcriptional regulator
ID12_RS00665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ID12_RS00670	COG0686	Belongs to the AlaDH PNT family
ID12_RS00675	COG1268	BioY protein
ID12_RS00680	COG2056	Na+-H+ antiporter family
ID12_RS00685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ID12_RS00690	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ID12_RS00695	COG3584	3D domain protein
ID12_RS00705	COG1252	NADH dehydrogenase
ID12_RS00710	COG0492	ferredoxin-NADP+ reductase activity
ID12_RS00725	COG0316	Belongs to the HesB IscA family
ID12_RS00730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ID12_RS00735	COG4844	belongs to the
ID12_RS00740	COG1252	NADH dehydrogenase
ID12_RS00750	COG4837	Protein of unknown function (DUF1462)
ID12_RS00755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ID12_RS00760	COG4946	Tricorn protease homolog
ID12_RS00760	COG1506	peptidase
ID12_RS00760	COG0823	Involved in the tonB-independent uptake of proteins
ID12_RS00765	COG0083	homoserine kinase activity
ID12_RS00770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ID12_RS00775	COG0460	homoserine dehydrogenase
ID12_RS00780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_RS00785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_RS00790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ID12_RS00795	COG0647	UMP catabolic process
ID12_RS00800	COG2445	Protein of unknown function DUF86
ID12_RS00805	COG4470	Protein conserved in bacteria
ID12_RS00815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ID12_RS00820	COG0739	heme binding
ID12_RS00840	COG3377	Domain of unknown function (DUF1805)
ID12_RS00845	COG0737	Belongs to the 5'-nucleotidase family
ID12_RS00850	COG1801	Protein of unknown function DUF72
ID12_RS00855	COG2508	Transcriptional regulator
ID12_RS00860	COG2140	Oxalate decarboxylase
ID12_RS00865	COG2814	Major facilitator Superfamily
ID12_RS00870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ID12_RS00875	COG2356	endonuclease I
ID12_RS00890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS00895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS00900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS00920	COG5002	protein histidine kinase activity
ID12_RS00920	COG0642	Histidine kinase
ID12_RS00925	COG0745	RESPONSE REGULATOR receiver
ID12_RS00930	COG2311	Membrane
ID12_RS00940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_RS00960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ID12_RS00970	COG0719	Fe-S assembly protein
ID12_RS00975	COG0822	iron-sulfur transferase activity
ID12_RS00980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ID12_RS00985	COG0719	Fe-S assembly protein
ID12_RS00990	COG0396	ATPase activity
ID12_RS00995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ID12_RS01000	COG1464	Belongs to the NlpA lipoprotein family
ID12_RS01005	COG2011	ABC-type metal ion transport system permease component
ID12_RS01010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ID12_RS01020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS01025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ID12_RS01035	COG0509	glycine decarboxylation via glycine cleavage system
ID12_RS01040	COG1393	Belongs to the ArsC family
ID12_RS01045	COG1960	acyl-CoA dehydrogenase activity
ID12_RS01050	COG0183	Belongs to the thiolase family
ID12_RS01055	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID12_RS01055	COG1024	Enoyl-CoA hydratase
ID12_RS01065	COG5577	PFAM Coat F domain
ID12_RS01075	COG1120	ATPase activity
ID12_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS01090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_RS01095	COG0745	RESPONSE REGULATOR receiver
ID12_RS01100	COG2205	protein histidine kinase activity
ID12_RS01100	COG2770	Histidine kinase
ID12_RS01105	COG1309	transcriptional regulator
ID12_RS01110	COG0114	fumarate hydratase activity
ID12_RS01115	COG0697	spore germination
ID12_RS01120	COG0814	amino acid
ID12_RS01135	COG2197	response regulator
ID12_RS01140	COG4585	Histidine kinase
ID12_RS01145	COG4758	membrane
ID12_RS01155	COG1842	Phage shock protein A
ID12_RS01160	COG4758	membrane
ID12_RS01165	COG2096	Adenosyltransferase
ID12_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS01175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ID12_RS01185	COG3604	Transcriptional regulator
ID12_RS01200	COG1454	alcohol dehydrogenase
ID12_RS01205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ID12_RS01210	COG1120	ATPase activity
ID12_RS01215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS01220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS01230	COG2721	sulfolactate sulfo-lyase activity
ID12_RS01235	COG0246	Mannitol dehydrogenase
ID12_RS01240	COG1609	Transcriptional regulator
ID12_RS01245	COG1904	glucuronate isomerase
ID12_RS01250	COG2205	protein histidine kinase activity
ID12_RS01255	COG0745	RESPONSE REGULATOR receiver
ID12_RS01260	COG1120	ATPase activity
ID12_RS01265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS01270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS01275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS01280	COG0531	amino acid
ID12_RS01295	COG1988	membrane-bound metal-dependent
ID12_RS01300	COG1368	sulfuric ester hydrolase activity
ID12_RS01305	COG0725	ABC transporter, periplasmic molybdate-binding protein
ID12_RS01310	COG4149	molybdate abc transporter
ID12_RS01315	COG0656	L-ascorbic acid biosynthetic process
ID12_RS01320	COG1940	carbohydrate kinase activity
ID12_RS01325	COG0025	NhaP-type Na H and K H
ID12_RS01330	COG2860	membrane
ID12_RS01335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ID12_RS01340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ID12_RS01345	COG2217	Heavy metal translocating P-type atpase
ID12_RS01350	COG1121	(ABC) transporter
ID12_RS01355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID12_RS01360	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID12_RS01370	COG3226	Transcriptional regulator
ID12_RS01375	COG0784	Response regulator, receiver
ID12_RS01380	COG4191	Histidine kinase
ID12_RS01385	COG1027	Aspartate ammonia-lyase
ID12_RS01395	COG2217	Heavy metal translocating P-type atpase
ID12_RS01400	COG2608	mercury ion transmembrane transporter activity
ID12_RS01405	COG1937	Protein conserved in bacteria
ID12_RS01435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ID12_RS01440	COG0557	exoribonuclease II activity
ID12_RS01445	COG1647	Serine aminopeptidase, S33
ID12_RS01450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ID12_RS01455	COG2002	toxin-antitoxin pair type II binding
ID12_RS01460	COG1476	TRANSCRIPTIONal
ID12_RS01465	COG1396	sequence-specific DNA binding
ID12_RS01470	COG1396	sequence-specific DNA binding
ID12_RS01475	COG1733	regulation of RNA biosynthetic process
ID12_RS01480	COG1174	glycine betaine transport
ID12_RS01485	COG1732	Glycine betaine
ID12_RS01490	COG1174	glycine betaine transport
ID12_RS01495	COG0517	IMP dehydrogenase activity
ID12_RS01495	COG1125	glycine betaine transport
ID12_RS01500	COG1510	regulation of RNA biosynthetic process
ID12_RS01505	COG2095	MarC family integral membrane protein
ID12_RS01515	COG0456	acetyltransferase
ID12_RS01535	COG1131	(ABC) transporter
ID12_RS01545	COG0148	phosphopyruvate hydratase activity
ID12_RS01550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ID12_RS01555	COG0149	triose-phosphate isomerase activity
ID12_RS01560	COG0126	phosphoglycerate kinase activity
ID12_RS01565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID12_RS01570	COG2390	Transcriptional regulator
ID12_RS01575	COG0833	amino acid
ID12_RS01580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID12_RS01585	COG3829	transcription factor binding
ID12_RS01590	COG2186	Transcriptional regulator
ID12_RS01595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ID12_RS01605	COG0534	Mate efflux family protein
ID12_RS01610	COG4608	Belongs to the ABC transporter superfamily
ID12_RS01615	COG0444	Belongs to the ABC transporter superfamily
ID12_RS01620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_RS01625	COG0601	transmembrane transport
ID12_RS01630	COG0747	negative chemotaxis
ID12_RS01635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_RS01640	COG0110	maltose O-acetyltransferase activity
ID12_RS01645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID12_RS01650	COG2244	polysaccharide biosynthetic process
ID12_RS01655	COG5039	Polysaccharide pyruvyl transferase
ID12_RS01660	COG1216	Glycosyl transferase, family 2
ID12_RS01670	COG0438	transferase activity, transferring glycosyl groups
ID12_RS01675	COG1215	transferase activity, transferring glycosyl groups
ID12_RS01680	COG0438	transferase activity, transferring glycosyl groups
ID12_RS01685	COG1086	Polysaccharide biosynthesis protein
ID12_RS01690	COG0489	protein tyrosine kinase activity
ID12_RS01695	COG3944	biosynthesis protein
ID12_RS01700	COG1396	sequence-specific DNA binding
ID12_RS01710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS01715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS01725	COG0726	polysaccharide deacetylase
ID12_RS01730	COG0488	(ABC) transporter
ID12_RS01750	COG0601	transmembrane transport
ID12_RS01755	COG0747	negative chemotaxis
ID12_RS01760	COG1819	glycosyl
ID12_RS01765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS01785	COG3177	Filamentation induced by cAMP protein fic
ID12_RS01800	COG0740	serine-type endopeptidase activity
ID12_RS01805	COG1611	Belongs to the LOG family
ID12_RS01810	COG1694	Mazg nucleotide pyrophosphohydrolase
ID12_RS01815	COG0659	secondary active sulfate transmembrane transporter activity
ID12_RS01820	COG0288	reversible hydration of carbon dioxide
ID12_RS01825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_RS01835	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ID12_RS01840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS01845	COG1481	regulation of sporulation
ID12_RS01850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ID12_RS01855	COG1660	Displays ATPase and GTPase activities
ID12_RS01860	COG1051	belongs to the nudix hydrolase family
ID12_RS01865	COG0492	ferredoxin-NADP+ reductase activity
ID12_RS01870	COG3883	PFAM NLP P60 protein
ID12_RS01870	COG0791	NLP P60 protein
ID12_RS01875	COG0457	Tetratricopeptide repeat
ID12_RS01880	COG0140	phosphoribosyl-ATP diphosphatase activity
ID12_RS01880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ID12_RS01885	COG0107	imidazoleglycerol-phosphate synthase activity
ID12_RS01890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ID12_RS01895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ID12_RS01900	COG0131	Imidazoleglycerol-phosphate dehydratase
ID12_RS01905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ID12_RS01910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ID12_RS01915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ID12_RS01920	COG4990	cell redox homeostasis
ID12_RS01930	COG2910	NAD(P)H-binding
ID12_RS01935	COG1959	2 iron, 2 sulfur cluster binding
ID12_RS01940	COG0110	maltose O-acetyltransferase activity
ID12_RS01945	COG0546	phosphoglycolate phosphatase activity
ID12_RS01950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ID12_RS01960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ID12_RS01965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ID12_RS01970	COG0363	glucosamine-6-phosphate deaminase activity
ID12_RS01975	COG2188	Transcriptional regulator
ID12_RS01980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ID12_RS01985	COG1950	PFAM Membrane protein of
ID12_RS01990	COG1983	PspC domain protein
ID12_RS01995	COG3595	metallopeptidase activity
ID12_RS02010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ID12_RS02020	COG4897	Protein conserved in bacteria
ID12_RS02025	COG3848	Pyruvate phosphate dikinase
ID12_RS02025	COG0574	Belongs to the PEP-utilizing enzyme family
ID12_RS02030	COG1309	transcriptional regulator
ID12_RS02035	COG2814	Major facilitator Superfamily
ID12_RS02045	COG0745	RESPONSE REGULATOR receiver
ID12_RS02050	COG5002	protein histidine kinase activity
ID12_RS02055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID12_RS02060	COG0463	Glycosyl transferase, family 2
ID12_RS02065	COG1113	amino acid transport
ID12_RS02070	COG0778	Nitroreductase
ID12_RS02075	COG1733	regulation of RNA biosynthetic process
ID12_RS02080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_RS02090	COG0793	Belongs to the peptidase S41A family
ID12_RS02090	COG3409	Peptidoglycan-binding domain 1 protein
ID12_RS02095	COG0730	response to heat
ID12_RS02100	COG3883	PFAM NLP P60 protein
ID12_RS02100	COG0791	NLP P60 protein
ID12_RS02105	COG2177	Part of the ABC transporter FtsEX involved in
ID12_RS02110	COG2884	Cell division ATP-binding protein ftsE
ID12_RS02115	COG2010	Cytochrome c
ID12_RS02120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_RS02135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ID12_RS02140	COG0653	protein targeting
ID12_RS02145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ID12_RS02150	COG0840	transmembrane signaling receptor activity
ID12_RS02165	COG1516	flagellar protein fliS
ID12_RS02170	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ID12_RS02175	COG1334	flagellar protein FlaG
ID12_RS02180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ID12_RS02185	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ID12_RS02195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_RS02200	COG4786	Flagellar basal body rod
ID12_RS02200	COG1256	bacterial-type flagellum assembly
ID12_RS02205	COG3418	PFAM FlgN family protein
ID12_RS02220	COG1040	competence protein
ID12_RS02230	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ID12_RS02235	COG1307	EDD domain protein, DegV family
ID12_RS02240	COG2197	response regulator
ID12_RS02245	COG4585	Histidine kinase
ID12_RS02250	COG1739	Uncharacterized protein family UPF0029
ID12_RS02255	COG1316	TRANSCRIPTIONal
ID12_RS02260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID12_RS02265	COG0438	transferase activity, transferring glycosyl groups
ID12_RS02270	COG1215	transferase activity, transferring glycosyl groups
ID12_RS02275	COG3206	protein involved in exopolysaccharide biosynthesis
ID12_RS02280	COG3307	-O-antigen
ID12_RS02285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_RS02290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ID12_RS02295	COG0438	transferase activity, transferring glycosyl groups
ID12_RS02295	COG0297	glycogen (starch) synthase activity
ID12_RS02300	COG2244	polysaccharide biosynthetic process
ID12_RS02315	COG2247	cell wall binding repeat
ID12_RS02315	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_RS02320	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_RS02320	COG2247	cell wall binding repeat
ID12_RS02325	COG2247	cell wall binding repeat
ID12_RS02325	COG2385	sporulation resulting in formation of a cellular spore
ID12_RS02335	COG1316	TRANSCRIPTIONal
ID12_RS02340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ID12_RS02345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ID12_RS02350	COG1134	teichoic acid transport
ID12_RS02355	COG1682	transport, permease protein
ID12_RS02365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_RS02375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ID12_RS02380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ID12_RS02385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_RS02390	COG4193	domain, Protein
ID12_RS02395	COG1482	cell wall glycoprotein biosynthetic process
ID12_RS02405	COG1175	transmembrane transport
ID12_RS02410	COG1653	transport
ID12_RS02415	COG2197	response regulator
ID12_RS02420	COG2972	Histidine kinase
ID12_RS02430	COG0454	-acetyltransferase
ID12_RS02435	COG0800	Aldolase
ID12_RS02440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID12_RS02445	COG1609	Transcriptional regulator
ID12_RS02450	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ID12_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS02460	COG0697	spore germination
ID12_RS02465	COG0814	amino acid
ID12_RS02480	COG2814	Major facilitator Superfamily
ID12_RS02485	COG1316	TRANSCRIPTIONal
ID12_RS02490	COG0561	phosphatase activity
ID12_RS02495	COG0791	NLP P60 protein
ID12_RS02500	COG2843	Capsule synthesis protein
ID12_RS02510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID12_RS02515	COG0697	spore germination
ID12_RS02530	COG1609	Transcriptional regulator
ID12_RS02535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID12_RS02540	COG1869	D-ribose catabolic process
ID12_RS02545	COG1129	ABC transporter
ID12_RS02550	COG1172	Belongs to the binding-protein-dependent transport system permease family
ID12_RS02555	COG1879	ABC-type sugar transport system periplasmic component
ID12_RS02560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ID12_RS02565	COG0583	DNA-binding transcription factor activity
ID12_RS02570	COG0028	Belongs to the TPP enzyme family
ID12_RS02575	COG3527	Alpha-acetolactate decarboxylase
ID12_RS02580	COG1522	sequence-specific DNA binding
ID12_RS02585	COG2059	Chromate
ID12_RS02590	COG2059	Chromate
ID12_RS02595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ID12_RS02600	COG4715	Zinc finger, swim domain protein
ID12_RS02605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ID12_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS02610	COG2202	Pas domain
ID12_RS02615	COG0561	phosphatase activity
ID12_RS02630	COG1970	mechanosensitive ion channel activity
ID12_RS02635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ID12_RS02640	COG0457	Tetratricopeptide repeat
ID12_RS02645	COG4786	Flagellar basal body rod
ID12_RS02650	COG4786	Flagellar basal body rod
ID12_RS02655	COG1077	Cell shape determining protein MreB Mrl
ID12_RS02660	COG1609	Transcriptional regulator
ID12_RS02665	COG1846	Transcriptional regulator
ID12_RS02670	COG2814	Major facilitator Superfamily
ID12_RS02675	COG0671	phosphoesterase, PA-phosphatase related
ID12_RS02680	COG0477	Major facilitator Superfamily
ID12_RS02685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS02690	COG0765	amino acid transport
ID12_RS02695	COG1126	abc transporter atp-binding protein
ID12_RS02700	COG0004	ammonium transporteR
ID12_RS02705	COG0347	Belongs to the P(II) protein family
ID12_RS02710	COG0739	heme binding
ID12_RS02715	COG1247	-acetyltransferase
ID12_RS02750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID12_RS02755	COG0523	cobalamin synthesis protein
ID12_RS02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID12_RS02765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ID12_RS02770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ID12_RS02775	COG2223	nitrite transmembrane transporter activity
ID12_RS02785	COG2304	oxidoreductase activity
ID12_RS02790	COG2304	oxidoreductase activity
ID12_RS02795	COG2385	sporulation resulting in formation of a cellular spore
ID12_RS02800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID12_RS02810	COG4836	Membrane
ID12_RS02820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ID12_RS02825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ID12_RS02830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ID12_RS02835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ID12_RS02840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID12_RS02845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ID12_RS02850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID12_RS02855	COG0356	it plays a direct role in the translocation of protons across the membrane
ID12_RS02865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ID12_RS02870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ID12_RS02875	COG4475	Protein of unknown function (DUF436)
ID12_RS02880	COG0698	ribose 5-phosphate isomerase
ID12_RS02885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_RS02890	COG1971	Probably functions as a manganese efflux pump
ID12_RS02895	COG0009	L-threonylcarbamoyladenylate synthase
ID12_RS02900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ID12_RS02915	COG2890	protein-(glutamine-N5) methyltransferase activity
ID12_RS02920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ID12_RS02925	COG0789	Transcriptional regulator
ID12_RS02930	COG0679	Auxin Efflux Carrier
ID12_RS02935	COG0281	malic enzyme
ID12_RS02940	COG1435	thymidine kinase activity
ID12_RS02945	COG0254	rRNA binding
ID12_RS02950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ID12_RS02955	COG1494	fructose-1,6-bisphosphatase
ID12_RS02960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID12_RS02965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ID12_RS02970	COG0191	fructose-bisphosphate aldolase activity
ID12_RS02975	COG2204	response regulator
ID12_RS02980	COG4821	SIS domain
ID12_RS02985	COG0504	CTP synthase activity
ID12_RS02990	COG3343	RNA polymerase activity
ID12_RS03005	COG1960	acyl-CoA dehydrogenase activity
ID12_RS03010	COG1960	acyl-CoA dehydrogenase activity
ID12_RS03015	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID12_RS03020	COG0183	Belongs to the thiolase family
ID12_RS03025	COG2181	nitrate reductase activity
ID12_RS03025	COG0247	lactate metabolic process
ID12_RS03030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_RS03035	COG4294	response to UV
ID12_RS03045	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_RS03055	COG1132	(ABC) transporter
ID12_RS03060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_RS03065	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_RS03075	COG0018	arginyl-trna synthetase
ID12_RS03080	COG4506	Protein conserved in bacteria
ID12_RS03090	COG0010	Belongs to the arginase family
ID12_RS03095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ID12_RS03100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_RS03110	COG1994	Peptidase M50
ID12_RS03115	COG1942	4-Oxalocrotonate Tautomerase
ID12_RS03125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS03130	COG0583	DNA-binding transcription factor activity
ID12_RS03135	COG0431	NADPH-dependent FMN reductase
ID12_RS03140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS03145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ID12_RS03150	COG0454	-acetyltransferase
ID12_RS03155	COG0765	amino acid transport
ID12_RS03165	COG0765	amino acid transport
ID12_RS03170	COG1126	abc transporter atp-binding protein
ID12_RS03175	COG3465	dGTPase activity
ID12_RS03180	COG1078	dGTPase activity
ID12_RS03185	COG4844	belongs to the
ID12_RS03245	COG5444	nuclease activity
ID12_RS03275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ID12_RS03285	COG0280	phosphate acetyltransferase
ID12_RS03295	COG2814	Major facilitator Superfamily
ID12_RS03300	COG1522	sequence-specific DNA binding
ID12_RS03305	COG2814	Major facilitator Superfamily
ID12_RS03310	COG0077	Prephenate dehydratase
ID12_RS03315	COG1917	Cupin 2, conserved barrel domain protein
ID12_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS03325	COG0151	Belongs to the GarS family
ID12_RS03330	COG0436	Aminotransferase
ID12_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS03340	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ID12_RS03345	COG1091	dTDP-4-dehydrorhamnose reductase activity
ID12_RS03350	COG1088	dTDP-glucose 4,6-dehydratase activity
ID12_RS03355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ID12_RS03360	COG3980	spore coat polysaccharide biosynthesis protein
ID12_RS03365	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ID12_RS03370	COG2089	acid synthase
ID12_RS03375	COG0456	acetyltransferase
ID12_RS03380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_RS03385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_RS03390	COG0463	Glycosyl transferase, family 2
ID12_RS03410	COG2363	Small membrane protein
ID12_RS03415	COG2233	PERMEase
ID12_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS03430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ID12_RS03435	COG1216	Glycosyl transferase, family 2
ID12_RS03445	COG0351	phosphomethylpyrimidine kinase
ID12_RS03460	COG1621	beta-fructofuranosidase activity
ID12_RS03465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS03465	COG1263	PTS System
ID12_RS03470	COG3711	transcriptional antiterminator
ID12_RS03480	COG1404	Belongs to the peptidase S8 family
ID12_RS03490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS03495	COG0778	Nitroreductase
ID12_RS03500	COG0772	Belongs to the SEDS family
ID12_RS03510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ID12_RS03515	COG1845	cytochrome c oxidase, subunit III
ID12_RS03520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ID12_RS03525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ID12_RS03535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ID12_RS03540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ID12_RS03545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ID12_RS03560	COG2246	polysaccharide biosynthetic process
ID12_RS03580	COG3162	membrane
ID12_RS03585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_RS03600	COG0352	thiamine-phosphate diphosphorylase activity
ID12_RS03605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ID12_RS03610	COG0583	DNA-binding transcription factor activity
ID12_RS03615	COG1380	Effector of murein hydrolase LrgA
ID12_RS03620	COG1346	cytolysis
ID12_RS03625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ID12_RS03630	COG0346	lactoylglutathione lyase activity
ID12_RS03640	COG0765	amino acid transport
ID12_RS03645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS03650	COG0457	Tetratricopeptide repeat
ID12_RS03655	COG2357	RelA SpoT domain protein
ID12_RS03660	COG1172	Belongs to the binding-protein-dependent transport system permease family
ID12_RS03665	COG1129	ABC transporter
ID12_RS03675	COG3420	alginic acid biosynthetic process
ID12_RS03680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_RS03695	COG1486	melibiose metabolic process
ID12_RS03700	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_RS03705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS03710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS03715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS03715	COG3711	transcriptional antiterminator
ID12_RS03730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_RS03745	COG1595	DNA-templated transcription, initiation
ID12_RS03755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ID12_RS03760	COG4988	ABC transporter
ID12_RS03765	COG1294	oxidase, subunit
ID12_RS03770	COG1271	oxidase subunit
ID12_RS03775	COG1120	ATPase activity
ID12_RS03780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS03785	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ID12_RS03790	COG4509	Sortase family
ID12_RS03815	COG5386	Cell surface protein
ID12_RS03820	COG5386	Cell surface protein
ID12_RS03825	COG1733	regulation of RNA biosynthetic process
ID12_RS03830	COG2514	catechol 2,3-dioxygenase activity
ID12_RS03835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_RS03835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_RS03840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_RS03840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_RS03850	COG0726	polysaccharide deacetylase
ID12_RS03855	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_RS03860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS03865	COG2723	6-phospho-beta-galactosidase activity
ID12_RS03870	COG1312	Catalyzes the dehydration of D-mannonate
ID12_RS03880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS03885	COG3711	transcriptional antiterminator
ID12_RS03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS03910	COG1757	Na H antiporter
ID12_RS03915	COG1027	Aspartate ammonia-lyase
ID12_RS03920	COG0252	asparaginase activity
ID12_RS03925	COG1396	sequence-specific DNA binding
ID12_RS03950	COG4842	Belongs to the WXG100 family
ID12_RS03955	COG2195	Cleaves the N-terminal amino acid of tripeptides
ID12_RS03970	COG1737	Transcriptional regulator
ID12_RS03975	COG2084	Dehydrogenase
ID12_RS03985	COG2610	gluconate transmembrane transporter activity
ID12_RS03990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ID12_RS04000	COG1136	(ABC) transporter
ID12_RS04005	COG2723	6-phospho-beta-galactosidase activity
ID12_RS04010	COG1263	PTS System
ID12_RS04010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS04010	COG2190	(PTS) system
ID12_RS04015	COG3711	transcriptional antiterminator
ID12_RS04020	COG3878	Protein conserved in bacteria
ID12_RS04030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_RS04035	COG1122	ATPase activity
ID12_RS04040	COG4721	ABC-type cobalt transport system, permease component
ID12_RS04045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ID12_RS04075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ID12_RS04080	COG0778	Nitroreductase
ID12_RS04085	COG1846	Transcriptional regulator
ID12_RS04090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ID12_RS04095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ID12_RS04100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ID12_RS04105	COG2390	Transcriptional regulator
ID12_RS04115	COG2755	lipolytic protein G-D-S-L family
ID12_RS04115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ID12_RS04120	COG0477	Major facilitator Superfamily
ID12_RS04130	COG2226	methyltransferase
ID12_RS04140	COG0561	phosphatase activity
ID12_RS04145	COG0789	Transcriptional regulator
ID12_RS04150	COG0673	inositol 2-dehydrogenase activity
ID12_RS04155	COG0840	transmembrane signaling receptor activity
ID12_RS04160	COG1113	amino acid transport
ID12_RS04165	COG4335	DNA alkylation repair
ID12_RS04175	COG1070	Carbohydrate kinase
ID12_RS04180	COG1737	Transcriptional regulator
ID12_RS04220	COG0583	DNA-binding transcription factor activity
ID12_RS04225	COG1609	Transcriptional regulator
ID12_RS04230	COG2182	Extracellular solute-binding protein
ID12_RS04235	COG1175	transmembrane transport
ID12_RS04240	COG3833	ABC-type maltose transport systems, permease component
ID12_RS04250	COG1874	Beta-galactosidase
ID12_RS04255	COG2851	Citrate transporter
ID12_RS04265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ID12_RS04270	COG1131	(ABC) transporter
ID12_RS04275	COG2824	Alkylphosphonate utilization operon protein PhnA
ID12_RS04280	COG1929	Belongs to the glycerate kinase type-1 family
ID12_RS04285	COG2610	gluconate transmembrane transporter activity
ID12_RS04290	COG3835	regulator
ID12_RS04295	COG1309	transcriptional regulator
ID12_RS04300	COG2814	Major facilitator Superfamily
ID12_RS04310	COG1136	(ABC) transporter
ID12_RS04320	COG0457	Tetratricopeptide repeat
ID12_RS04325	COG3711	transcriptional antiterminator
ID12_RS04330	COG2723	6-phospho-beta-galactosidase activity
ID12_RS04335	COG2190	(PTS) system
ID12_RS04335	COG1263	PTS System
ID12_RS04335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS04360	COG0494	nUDIX hydrolase
ID12_RS04375	COG1113	amino acid transport
ID12_RS04380	COG1609	Transcriptional regulator
ID12_RS04385	COG2814	Major facilitator Superfamily
ID12_RS04390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ID12_RS04395	COG2814	Major facilitator Superfamily
ID12_RS04415	COG5444	nuclease activity
ID12_RS04425	COG2723	6-phospho-beta-galactosidase activity
ID12_RS04430	COG1263	PTS System
ID12_RS04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS04430	COG2190	(PTS) system
ID12_RS04435	COG2188	Transcriptional regulator
ID12_RS04450	COG0384	phenazine biosynthesis protein PhzF
ID12_RS04455	COG0583	DNA-binding transcription factor activity
ID12_RS04475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID12_RS04490	COG1234	tRNA 3'-trailer cleavage
ID12_RS04515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ID12_RS04520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_RS04530	COG4720	Psort location CytoplasmicMembrane, score
ID12_RS04550	COG0456	acetyltransferase
ID12_RS04555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_RS04560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ID12_RS04565	COG4853	Protein conserved in bacteria
ID12_RS04570	COG4863	YycH protein
ID12_RS04575	COG5002	protein histidine kinase activity
ID12_RS04580	COG0745	RESPONSE REGULATOR receiver
ID12_RS04605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ID12_RS04615	COG2311	Membrane
ID12_RS04620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ID12_RS04625	COG1309	transcriptional regulator
ID12_RS04630	COG2124	cytochrome p450
ID12_RS04635	COG0346	lactoylglutathione lyase activity
ID12_RS04640	COG0305	Participates in initiation and elongation during chromosome replication
ID12_RS04655	COG2819	hydrolase of the alpha beta superfamily
ID12_RS04660	COG2207	Transcriptional regulator
ID12_RS04660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS04665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS04670	COG2819	hydrolase of the alpha beta superfamily
ID12_RS04675	COG2807	transmembrane transport
ID12_RS04680	COG0359	binds to the 23S rRNA
ID12_RS04685	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ID12_RS04690	COG4241	membrane
ID12_RS04695	COG1227	inorganic diphosphatase activity
ID12_RS04705	COG1595	DNA-templated transcription, initiation
ID12_RS04715	COG0753	catalase activity
ID12_RS04720	COG0655	NAD(P)H dehydrogenase (quinone) activity
ID12_RS04725	COG0400	carboxylic ester hydrolase activity
ID12_RS04730	COG0346	lactoylglutathione lyase activity
ID12_RS04735	COG1174	glycine betaine transport
ID12_RS04740	COG1125	glycine betaine transport
ID12_RS04740	COG0517	IMP dehydrogenase activity
ID12_RS04745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ID12_RS04750	COG0629	single-stranded DNA binding
ID12_RS04755	COG0360	Binds together with S18 to 16S ribosomal RNA
ID12_RS04760	COG0012	GTP binding
ID12_RS04765	COG4481	Protein conserved in bacteria
ID12_RS04780	COG3949	Membrane
ID12_RS04790	COG1475	DNA binding
ID12_RS04795	COG1192	Involved in chromosome partitioning
ID12_RS04805	COG1475	DNA binding
ID12_RS04810	COG0357	Ribosomal RNA small subunit methyltransferase G
ID12_RS04815	COG0445	tRNA wobble uridine modification
ID12_RS04820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ID12_RS04825	COG1847	R3H domain protein
ID12_RS04830	COG0706	membrane insertase activity
ID12_RS04835	COG0594	ribonuclease P activity
ID12_RS04840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ID12_RS04845	COG0592	DNA-directed DNA polymerase activity
ID12_RS04850	COG2501	S4 domain
ID12_RS04855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID12_RS04865	COG0187	DNA topoisomerase II activity
ID12_RS04870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID12_RS04905	COG0516	GMP reductase activity
ID12_RS04905	COG0517	IMP dehydrogenase activity
ID12_RS04910	COG1686	Belongs to the peptidase S11 family
ID12_RS04915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS04920	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ID12_RS04925	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ID12_RS04930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ID12_RS04935	COG0840	transmembrane signaling receptor activity
ID12_RS04945	COG1428	Deoxynucleoside kinase
ID12_RS04950	COG1428	Deoxynucleoside kinase
ID12_RS04955	COG3858	chitin binding
ID12_RS04955	COG1388	LysM domain
ID12_RS04960	COG1335	isochorismatase
ID12_RS04965	COG0590	tRNA wobble adenosine to inosine editing
ID12_RS04970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ID12_RS04975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ID12_RS04980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ID12_RS05025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ID12_RS05030	COG3853	Toxic anion resistance protein (TelA)
ID12_RS05035	COG1982	Orn Lys Arg decarboxylase major
ID12_RS05040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ID12_RS05045	COG3870	Protein conserved in bacteria
ID12_RS05050	COG1728	Protein conserved in bacteria
ID12_RS05055	COG0470	DNA polymerase III
ID12_RS05060	COG1774	PSP1 C-terminal conserved region
ID12_RS05065	COG4467	Involved in initiation control of chromosome replication
ID12_RS05070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ID12_RS05075	COG2827	Endonuclease containing a URI domain
ID12_RS05080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ID12_RS05085	COG2002	toxin-antitoxin pair type II binding
ID12_RS05090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_RS05090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_RS05095	COG0084	hydrolase, TatD family'
ID12_RS05100	COG3583	domain protein
ID12_RS05100	COG3584	3D domain protein
ID12_RS05105	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ID12_RS05110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ID12_RS05120	COG4466	Protein conserved in bacteria
ID12_RS05130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ID12_RS05135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_RS05140	COG0251	oxidation-reduction process
ID12_RS05145	COG2088	sporulation resulting in formation of a cellular spore
ID12_RS05155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ID12_RS05160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ID12_RS05165	COG0193	aminoacyl-tRNA hydrolase activity
ID12_RS05175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ID12_RS05180	COG2002	toxin-antitoxin pair type II binding
ID12_RS05185	COG2244	polysaccharide biosynthetic process
ID12_RS05190	COG3956	TIGRFAM MazG family protein
ID12_RS05195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ID12_RS05210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ID12_RS05215	COG1098	S1 RNA binding domain
ID12_RS05230	COG2208	phosphoserine phosphatase activity
ID12_RS05235	COG2304	oxidoreductase activity
ID12_RS05240	COG0515	serine threonine protein kinase
ID12_RS05245	COG0037	tRNA processing
ID12_RS05250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ID12_RS05255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ID12_RS05260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ID12_RS05265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ID12_RS05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID12_RS05275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_RS05280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ID12_RS05285	COG0512	Glutamine amidotransferase of anthranilate synthase
ID12_RS05290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_RS05295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ID12_RS05300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ID12_RS05305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ID12_RS05310	COG1396	sequence-specific DNA binding
ID12_RS05315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID12_RS05320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ID12_RS05400	COG4463	regulation of RNA biosynthetic process
ID12_RS05405	COG3880	PFAM UvrB UvrC protein
ID12_RS05410	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ID12_RS05415	COG0542	response to heat
ID12_RS05420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ID12_RS05425	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ID12_RS05430	COG4956	integral membrane protein (PIN domain superfamily)
ID12_RS05435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ID12_RS05440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ID12_RS05445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID12_RS05450	COG1045	serine acetyltransferase
ID12_RS05455	COG0215	cysteine-tRNA ligase activity
ID12_RS05460	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ID12_RS05465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID12_RS05470	COG3688	RNA-binding protein containing a PIN domain
ID12_RS05475	COG1595	DNA-templated transcription, initiation
ID12_RS05480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ID12_RS05485	COG0250	Participates in transcription elongation, termination and antitermination
ID12_RS05495	COG0081	regulation of translation
ID12_RS05500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ID12_RS05505	COG0222	ribosome binding
ID12_RS05510	COG2813	Specifically methylates the guanine in position
ID12_RS05515	COG0085	RNA polymerase activity
ID12_RS05520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ID12_RS05525	COG1358	cellular component organization or biogenesis
ID12_RS05530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ID12_RS05535	COG0049	tRNA binding
ID12_RS05540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ID12_RS05545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ID12_RS05550	COG0596	Alpha beta hydrolase
ID12_RS05560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ID12_RS05565	COG0088	Forms part of the polypeptide exit tunnel
ID12_RS05570	COG0089	rRNA binding
ID12_RS05575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ID12_RS05580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ID12_RS05585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ID12_RS05590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ID12_RS05595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ID12_RS05600	COG0255	Belongs to the universal ribosomal protein uL29 family
ID12_RS05605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ID12_RS05610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ID12_RS05615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ID12_RS05620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ID12_RS05625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID12_RS05630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ID12_RS05635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ID12_RS05640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ID12_RS05645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ID12_RS05650	COG1841	ribosomal large subunit assembly
ID12_RS05655	COG0200	Binds to the 23S rRNA
ID12_RS05660	COG0201	protein transport
ID12_RS05665	COG0563	adenylate kinase activity
ID12_RS05670	COG0024	Methionine aminopeptidase
ID12_RS05675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ID12_RS05680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ID12_RS05685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ID12_RS05690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ID12_RS05695	COG0202	RNA polymerase activity
ID12_RS05700	COG0203	ribosomal protein L17
ID12_RS05705	COG1122	ATPase activity
ID12_RS05710	COG1122	ATPase activity
ID12_RS05715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_RS05720	COG0101	tRNA pseudouridine synthase activity
ID12_RS05725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ID12_RS05730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ID12_RS05735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS05760	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_RS05765	COG0489	protein tyrosine kinase activity
ID12_RS05775	COG2194	sulfuric ester hydrolase activity
ID12_RS05780	COG0726	polysaccharide deacetylase
ID12_RS05810	COG0659	secondary active sulfate transmembrane transporter activity
ID12_RS05815	COG0385	Bile acid
ID12_RS05820	COG3876	Protein conserved in bacteria
ID12_RS05825	COG1472	Belongs to the glycosyl hydrolase 3 family
ID12_RS05830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID12_RS05835	COG1263	PTS System
ID12_RS05835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS05840	COG1737	Transcriptional regulator
ID12_RS05845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ID12_RS05880	COG1595	DNA-templated transcription, initiation
ID12_RS05885	COG5662	AntiSigma factor
ID12_RS05890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID12_RS05895	COG4856	YbbR-like protein
ID12_RS05900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID12_RS05905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ID12_RS05920	COG1131	(ABC) transporter
ID12_RS05930	COG1136	(ABC) transporter
ID12_RS05960	COG3402	PFAM membrane-flanked domain
ID12_RS05965	COG1131	(ABC) transporter
ID12_RS06015	COG2311	Membrane
ID12_RS06035	COG1476	TRANSCRIPTIONal
ID12_RS06045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ID12_RS06050	COG2207	Transcriptional regulator
ID12_RS06055	COG1309	transcriptional regulator
ID12_RS06070	COG1113	amino acid transport
ID12_RS06075	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_RS06080	COG2271	Major facilitator Superfamily
ID12_RS06090	COG1331	Highly conserved protein containing a thioredoxin domain
ID12_RS06095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID12_RS06110	COG0640	Transcriptional regulator
ID12_RS06125	COG1937	Protein conserved in bacteria
ID12_RS06130	COG2210	Belongs to the sulfur carrier protein TusA family
ID12_RS06140	COG0425	Belongs to the sulfur carrier protein TusA family
ID12_RS06140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_RS06145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_RS06145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_RS06150	COG0425	Belongs to the sulfur carrier protein TusA family
ID12_RS06155	COG0730	response to heat
ID12_RS06160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_RS06165	COG2814	Major facilitator Superfamily
ID12_RS06180	COG1846	Transcriptional regulator
ID12_RS06190	COG1683	Conserved Protein
ID12_RS06195	COG0656	L-ascorbic acid biosynthetic process
ID12_RS06200	COG0371	Dehydrogenase
ID12_RS06205	COG1054	Belongs to the UPF0176 family
ID12_RS06210	COG0531	amino acid
ID12_RS06220	COG3711	transcriptional antiterminator
ID12_RS06225	COG2190	(PTS) system
ID12_RS06225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS06225	COG1263	PTS System
ID12_RS06230	COG2723	6-phospho-beta-galactosidase activity
ID12_RS06245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS06245	COG3711	transcriptional antiterminator
ID12_RS06250	COG1940	carbohydrate kinase activity
ID12_RS06255	COG0383	alpha-mannosidase activity
ID12_RS06260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS06265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS06270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS06270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS06275	COG1404	Belongs to the peptidase S8 family
ID12_RS06290	COG0833	amino acid
ID12_RS06295	COG2040	homocysteine
ID12_RS06300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_RS06305	COG1695	Transcriptional regulator
ID12_RS06315	COG2814	Major facilitator Superfamily
ID12_RS06320	COG0456	acetyltransferase
ID12_RS06335	COG1404	Belongs to the peptidase S8 family
ID12_RS06345	COG1309	transcriptional regulator
ID12_RS06350	COG1917	Cupin 2, conserved barrel domain protein
ID12_RS06355	COG1063	alcohol dehydrogenase
ID12_RS06360	COG1846	Transcriptional regulator
ID12_RS06365	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS06370	COG0531	amino acid
ID12_RS06380	COG0596	Alpha beta hydrolase
ID12_RS06385	COG1115	amino acid carrier protein
ID12_RS06390	COG2066	Belongs to the glutaminase family
ID12_RS06395	COG4191	Histidine kinase
ID12_RS06400	COG0784	Response regulator, receiver
ID12_RS06405	COG3012	SEC-C Motif Domain Protein
ID12_RS06405	COG1405	negative regulation of cell septum assembly
ID12_RS06415	COG0667	Aldo Keto reductase
ID12_RS06420	COG3290	protein histidine kinase activity
ID12_RS06425	COG3279	Response regulator of the LytR AlgR family
ID12_RS06430	COG4555	ABC transporter
ID12_RS06435	COG1668	transmembrane transport
ID12_RS06455	COG3773	Cell wall hydrolase
ID12_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS06470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS06475	COG2310	stress, protein
ID12_RS06480	COG2310	stress, protein
ID12_RS06485	COG2310	stress, protein
ID12_RS06490	COG0861	Integral membrane protein TerC family
ID12_RS06520	COG3853	Toxic anion resistance protein (TelA)
ID12_RS06525	COG0517	IMP dehydrogenase activity
ID12_RS06525	COG4175	Glycine betaine
ID12_RS06530	COG4176	ABC-type proline glycine betaine transport system permease component
ID12_RS06535	COG2113	Glycine betaine
ID12_RS06550	COG1473	amidohydrolase
ID12_RS06555	COG1288	antiporter activity
ID12_RS06560	COG0039	L-malate dehydrogenase activity
ID12_RS06565	COG1620	l-lactate permease
ID12_RS06570	COG1609	Transcriptional regulator
ID12_RS06575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_RS06580	COG0561	phosphatase activity
ID12_RS06585	COG0673	inositol 2-dehydrogenase activity
ID12_RS06590	COG0738	Major facilitator superfamily
ID12_RS06595	COG1280	lysine exporter protein (LysE YggA)
ID12_RS06610	COG3403	YqcI/YcgG family
ID12_RS06615	COG1113	amino acid transport
ID12_RS06620	COG3665	Urea carboxylase-associated protein
ID12_RS06625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ID12_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS06660	COG0710	3-dehydroquinate dehydratase activity
ID12_RS06665	COG0028	Belongs to the TPP enzyme family
ID12_RS06675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ID12_RS06680	COG2271	Major facilitator Superfamily
ID12_RS06695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ID12_RS06700	COG2226	methyltransferase
ID12_RS06705	COG0583	DNA-binding transcription factor activity
ID12_RS06710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID12_RS06715	COG3458	cephalosporin-C deacetylase activity
ID12_RS06725	COG3541	Predicted nucleotidyltransferase
ID12_RS06730	COG0506	proline dehydrogenase activity
ID12_RS06735	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS06740	COG2508	Transcriptional regulator
ID12_RS06745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ID12_RS06750	COG0765	amino acid transport
ID12_RS06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS06765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ID12_RS06770	COG1522	sequence-specific DNA binding
ID12_RS06775	COG2746	aminoglycoside 3-N-acetyltransferase activity
ID12_RS06785	COG0840	transmembrane signaling receptor activity
ID12_RS06785	COG3290	protein histidine kinase activity
ID12_RS06790	COG3209	COG3209 Rhs family protein
ID12_RS06815	COG3842	ATPase activity
ID12_RS06820	COG1176	ABC-type spermidine putrescine transport system, permease component I
ID12_RS06830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_RS06835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_RS06840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_RS06855	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ID12_RS06870	COG4555	ABC transporter
ID12_RS06885	COG0697	spore germination
ID12_RS06890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS06900	COG2207	Transcriptional regulator
ID12_RS06900	COG3708	Transcriptional regulator
ID12_RS06910	COG2364	Membrane
ID12_RS06915	COG1126	abc transporter atp-binding protein
ID12_RS06920	COG0765	amino acid transport
ID12_RS06925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS06930	COG0412	Dienelactone hydrolase
ID12_RS06935	COG0833	amino acid
ID12_RS06940	COG3104	oligopeptide transport
ID12_RS06945	COG5434	Belongs to the glycosyl hydrolase 28 family
ID12_RS06950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS06955	COG0456	acetyltransferase
ID12_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS06965	COG0765	amino acid transport
ID12_RS06970	COG1126	abc transporter atp-binding protein
ID12_RS06975	COG1473	amidohydrolase
ID12_RS06980	COG2079	MmgE PrpD family protein
ID12_RS06985	COG0745	RESPONSE REGULATOR receiver
ID12_RS06990	COG3850	Histidine kinase
ID12_RS06990	COG5002	protein histidine kinase activity
ID12_RS06995	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS07000	COG0527	aspartate kinase activity
ID12_RS07005	COG2814	Major facilitator Superfamily
ID12_RS07010	COG1309	transcriptional regulator
ID12_RS07020	COG0640	Transcriptional regulator
ID12_RS07030	COG0583	DNA-binding transcription factor activity
ID12_RS07035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS07040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ID12_RS07045	COG0531	amino acid
ID12_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS07055	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_RS07060	COG4549	nuclear export factor GLE1
ID12_RS07065	COG1276	copper resistance
ID12_RS07065	COG2372	response to copper ion
ID12_RS07070	COG2213	PTS system mannitol-specific
ID12_RS07075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS07080	COG0246	Mannitol dehydrogenase
ID12_RS07085	COG0840	transmembrane signaling receptor activity
ID12_RS07120	COG0346	lactoylglutathione lyase activity
ID12_RS07130	COG0561	phosphatase activity
ID12_RS07135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ID12_RS07140	COG1914	H( )-stimulated, divalent metal cation uptake system
ID12_RS07145	COG4336	lyase activity
ID12_RS07150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ID12_RS07155	COG1984	allophanate hydrolase subunit 2
ID12_RS07160	COG1414	Transcriptional regulator
ID12_RS07165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_RS07170	COG2755	lipolytic protein G-D-S-L family
ID12_RS07180	COG3711	transcriptional antiterminator
ID12_RS07185	COG2226	methyltransferase
ID12_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS07195	COG3871	stress protein (general stress protein 26)
ID12_RS07215	COG2814	Major facilitator Superfamily
ID12_RS07220	COG1802	Transcriptional regulator
ID12_RS07230	COG0697	spore germination
ID12_RS07235	COG0473	3-isopropylmalate dehydrogenase activity
ID12_RS07240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ID12_RS07240	COG0551	DNA topoisomerase type I activity
ID12_RS07245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ID12_RS07250	COG3706	GGDEF domain
ID12_RS07255	COG5298	Protein conserved in bacteria
ID12_RS07260	COG1215	transferase activity, transferring glycosyl groups
ID12_RS07270	COG0531	amino acid
ID12_RS07275	COG0028	Belongs to the TPP enzyme family
ID12_RS07280	COG5444	nuclease activity
ID12_RS07300	COG5444	nuclease activity
ID12_RS07320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS07325	COG1914	H( )-stimulated, divalent metal cation uptake system
ID12_RS07330	COG2261	transglycosylase associated protein
ID12_RS07335	COG2217	Heavy metal translocating P-type atpase
ID12_RS07340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ID12_RS07345	COG3290	protein histidine kinase activity
ID12_RS07350	COG4565	transcriptional regulatory protein
ID12_RS07355	COG1301	dicarboxylic acid transport
ID12_RS07360	COG0628	permease
ID12_RS07365	COG1301	dicarboxylic acid transport
ID12_RS07370	COG1131	(ABC) transporter
ID12_RS07375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ID12_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS07390	COG1181	Belongs to the D-alanine--D-alanine ligase family
ID12_RS07395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ID12_RS07410	COG0513	Belongs to the DEAD box helicase family
ID12_RS07415	COG3402	PFAM membrane-flanked domain
ID12_RS07420	COG3428	Bacterial PH domain
ID12_RS07425	COG0705	Rhomboid family
ID12_RS07430	COG0736	holo-[acyl-carrier-protein] synthase activity
ID12_RS07435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ID12_RS07440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ID12_RS07445	COG0864	Transcriptional regulator
ID12_RS07450	COG2337	Toxic component of a toxin-antitoxin (TA) module
ID12_RS07455	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS07460	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS07465	COG2172	sigma factor antagonist activity
ID12_RS07470	COG2208	phosphoserine phosphatase activity
ID12_RS07475	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS07480	COG2172	sigma factor antagonist activity
ID12_RS07485	COG1191	sigma factor activity
ID12_RS07490	COG2208	phosphoserine phosphatase activity
ID12_RS07495	COG2183	response to ionizing radiation
ID12_RS07500	COG3091	SprT-like family
ID12_RS07540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ID12_RS07550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS07565	COG1278	Cold shock
ID12_RS07570	COG1329	Transcriptional regulator
ID12_RS07575	COG1064	alcohol dehydrogenase
ID12_RS07580	COG0789	Transcriptional regulator
ID12_RS07595	COG0477	Major facilitator Superfamily
ID12_RS07600	COG0657	acetylesterase activity
ID12_RS07610	COG4221	oxidoreductase activity
ID12_RS07620	COG0252	asparaginase activity
ID12_RS07640	COG2814	Major facilitator Superfamily
ID12_RS07685	COG1309	transcriptional regulator
ID12_RS07690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID12_RS07695	COG1846	Transcriptional regulator
ID12_RS07700	COG0778	Nitroreductase
ID12_RS07715	COG1396	sequence-specific DNA binding
ID12_RS07725	COG0456	acetyltransferase
ID12_RS07735	COG4122	O-methyltransferase activity
ID12_RS07745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ID12_RS07750	COG0697	spore germination
ID12_RS07760	COG1301	dicarboxylic acid transport
ID12_RS07800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ID12_RS07805	COG0802	atpase or kinase
ID12_RS07810	COG1214	PFAM Peptidase M22, glycoprotease
ID12_RS07815	COG0456	acetyltransferase
ID12_RS07820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ID12_RS07825	COG0488	(ABC) transporter
ID12_RS07830	COG0315	cyclic pyranopterin monophosphate synthase activity
ID12_RS07835	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ID12_RS07840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ID12_RS07845	COG0805	protein transport
ID12_RS07860	COG1266	CAAX protease self-immunity
ID12_RS07865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ID12_RS07870	COG0459	protein refolding
ID12_RS07875	COG1846	Transcriptional regulator
ID12_RS07880	COG2808	Putative FMN-binding domain
ID12_RS07885	COG1876	peptidase activity
ID12_RS07910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ID12_RS07915	COG0823	Involved in the tonB-independent uptake of proteins
ID12_RS07925	COG2132	Multicopper oxidase
ID12_RS07930	COG1113	amino acid transport
ID12_RS07935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ID12_RS07940	COG0714	Associated with various cellular activities
ID12_RS07945	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ID12_RS07950	COG1305	Transglutaminase-like
ID12_RS07955	COG0519	Catalyzes the synthesis of GMP from XMP
ID12_RS07955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ID12_RS07985	COG1595	DNA-templated transcription, initiation
ID12_RS07995	COG2814	Major facilitator Superfamily
ID12_RS08000	COG0583	DNA-binding transcription factor activity
ID12_RS08005	COG2252	PERMEase
ID12_RS08010	COG5583	Uncharacterized small protein (DUF2292)
ID12_RS08015	COG3064	Membrane
ID12_RS08020	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ID12_RS08030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ID12_RS08035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ID12_RS08040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ID12_RS08045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ID12_RS08050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID12_RS08055	COG0047	phosphoribosylformylglycinamidine synthase activity
ID12_RS08060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID12_RS08065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ID12_RS08070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ID12_RS08075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ID12_RS08080	COG0138	bifunctional purine biosynthesis protein purh
ID12_RS08085	COG0151	Belongs to the GarS family
ID12_RS08105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ID12_RS08110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ID12_RS08115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ID12_RS08120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID12_RS08130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID12_RS08135	COG4496	protein, YerC YecD
ID12_RS08145	COG0069	glutamate synthase activity
ID12_RS08160	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ID12_RS08165	COG0210	DNA helicase
ID12_RS08170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ID12_RS08175	COG4851	CamS sex pheromone cAM373 precursor
ID12_RS08185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_RS08190	COG1285	pathogenesis
ID12_RS08195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_RS08200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID12_RS08205	COG0154	amidase activity
ID12_RS08210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID12_RS08215	COG1309	transcriptional regulator
ID12_RS08220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID12_RS08225	COG1957	nucleoside hydrolase
ID12_RS08230	COG1597	lipid kinase activity
ID12_RS08235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID12_RS08240	COG1122	ATPase activity
ID12_RS08245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID12_RS08260	COG1959	2 iron, 2 sulfur cluster binding
ID12_RS08265	COG0492	ferredoxin-NADP+ reductase activity
ID12_RS08280	COG1486	melibiose metabolic process
ID12_RS08290	COG2211	Major facilitator Superfamily
ID12_RS08315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ID12_RS08320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_RS08325	COG1442	glycosyl transferase family 8
ID12_RS08330	COG1216	Glycosyl transferase, family 2
ID12_RS08335	COG1442	glycosyl transferase family 8
ID12_RS08340	COG2223	nitrite transmembrane transporter activity
ID12_RS08350	COG0471	metal ion transport
ID12_RS08365	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_RS08380	COG0531	amino acid
ID12_RS08385	COG0463	Glycosyl transferase, family 2
ID12_RS08385	COG0457	Tetratricopeptide repeat
ID12_RS08390	COG0488	(ABC) transporter
ID12_RS08395	COG1469	GTP cyclohydrolase I activity
ID12_RS08400	COG0789	Transcriptional regulator
ID12_RS08405	COG2814	Major facilitator Superfamily
ID12_RS08410	COG0488	(ABC) transporter
ID12_RS08415	COG0513	Belongs to the DEAD box helicase family
ID12_RS08420	COG2130	NADP-dependent
ID12_RS08440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_RS08440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_RS08445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID12_RS08455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_RS08455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_RS08465	COG3290	protein histidine kinase activity
ID12_RS08470	COG4565	transcriptional regulatory protein
ID12_RS08475	COG3181	Tripartite tricarboxylate transporter family receptor
ID12_RS08480	COG2851	Citrate transporter
ID12_RS08490	COG3479	Phenolic acid decarboxylase
ID12_RS08495	COG1695	Transcriptional regulator
ID12_RS08500	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ID12_RS08510	COG1254	Belongs to the acylphosphatase family
ID12_RS08515	COG2258	MOSC domain
ID12_RS08520	COG0024	Methionine aminopeptidase
ID12_RS08525	COG1263	PTS System
ID12_RS08525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS08530	COG3739	integral membrane protein
ID12_RS08545	COG1368	sulfuric ester hydrolase activity
ID12_RS08550	COG0076	glutamate decarboxylase activity
ID12_RS08555	COG0840	transmembrane signaling receptor activity
ID12_RS08565	COG1263	PTS System
ID12_RS08565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS08570	COG0366	Alpha amylase catalytic
ID12_RS08575	COG2188	Transcriptional regulator
ID12_RS08585	COG0737	Belongs to the 5'-nucleotidase family
ID12_RS08590	COG0693	protein deglycase activity
ID12_RS08595	COG4840	Belongs to the UPF0435 family
ID12_RS08600	COG1115	amino acid carrier protein
ID12_RS08605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_RS08610	COG4980	gas vesicle protein
ID12_RS08615	COG1295	ribonuclease BN
ID12_RS08620	COG0477	Major facilitator Superfamily
ID12_RS08630	COG0387	Pfam Sodium calcium exchanger
ID12_RS08640	COG0217	transcriptional regulatory protein
ID12_RS08650	COG0668	transmembrane transport
ID12_RS08655	COG0535	radical SAM domain protein
ID12_RS08665	COG0726	polysaccharide deacetylase
ID12_RS08675	COG0598	Magnesium transport protein CorA
ID12_RS08685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ID12_RS08690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID12_RS08720	COG0789	Transcriptional regulator
ID12_RS08725	COG2814	Major facilitator Superfamily
ID12_RS08740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_RS08790	COG2076	Multidrug Resistance protein
ID12_RS08795	COG2076	Multidrug Resistance protein
ID12_RS08800	COG1309	transcriptional regulator
ID12_RS08810	COG4637	Psort location Cytoplasmic, score
ID12_RS08815	COG2755	lipolytic protein G-D-S-L family
ID12_RS08820	COG0492	ferredoxin-NADP+ reductase activity
ID12_RS08825	COG2169	Transcriptional regulator
ID12_RS08830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ID12_RS08835	COG1132	(ABC) transporter
ID12_RS08840	COG1742	UPF0060 membrane protein
ID12_RS08845	COG1595	DNA-templated transcription, initiation
ID12_RS08865	COG2318	DinB family
ID12_RS08875	COG1846	Transcriptional regulator
ID12_RS08880	COG0392	lysyltransferase activity
ID12_RS08880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ID12_RS08900	COG0778	Nitroreductase
ID12_RS08910	COG1090	epimerase
ID12_RS08915	COG2137	regulation of response to DNA damage stimulus
ID12_RS08935	COG0463	Glycosyl transferase, family 2
ID12_RS08940	COG4485	Bacterial membrane protein, YfhO
ID12_RS08945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ID12_RS08960	COG2140	Oxalate decarboxylase
ID12_RS08965	COG1191	sigma factor activity
ID12_RS08975	COG1988	membrane-bound metal-dependent
ID12_RS08980	COG1194	a g-specific adenine glycosylase
ID12_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS09005	COG3557	Belongs to the UPF0374 family
ID12_RS09010	COG1132	(ABC) transporter
ID12_RS09015	COG0444	Belongs to the ABC transporter superfamily
ID12_RS09020	COG4608	Belongs to the ABC transporter superfamily
ID12_RS09025	COG0747	negative chemotaxis
ID12_RS09030	COG0601	transmembrane transport
ID12_RS09035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_RS09040	COG4129	membrane
ID12_RS09045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ID12_RS09050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ID12_RS09055	COG0735	belongs to the Fur family
ID12_RS09205	COG1368	sulfuric ester hydrolase activity
ID12_RS09210	COG0681	Belongs to the peptidase S26 family
ID12_RS09215	COG2873	o-acetylhomoserine
ID12_RS09225	COG1116	anion transmembrane transporter activity
ID12_RS09230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ID12_RS09235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ID12_RS09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS09255	COG1131	(ABC) transporter
ID12_RS09285	COG3382	B3 4 domain protein
ID12_RS09290	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ID12_RS09300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ID12_RS09305	COG2766	serine protein kinase
ID12_RS09310	COG2718	Belongs to the UPF0229 family
ID12_RS09315	COG1566	PFAM secretion protein HlyD family protein
ID12_RS09320	COG2814	Major facilitator Superfamily
ID12_RS09325	COG0655	NAD(P)H dehydrogenase (quinone) activity
ID12_RS09335	COG1278	Cold shock
ID12_RS09340	COG3706	GGDEF domain
ID12_RS09360	COG5577	PFAM Coat F domain
ID12_RS09365	COG5002	protein histidine kinase activity
ID12_RS09370	COG0737	Belongs to the 5'-nucleotidase family
ID12_RS09370	COG1525	nuclease
ID12_RS09370	COG4085	toxin activity
ID12_RS09375	COG3764	Sortase (surface protein transpeptidase)
ID12_RS09380	COG0564	pseudouridine synthase activity
ID12_RS09390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ID12_RS09395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID12_RS09395	COG3153	acetyltransferase
ID12_RS09415	COG3835	regulator
ID12_RS09420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ID12_RS09425	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ID12_RS09430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID12_RS09435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ID12_RS09440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ID12_RS09445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID12_RS09450	COG2203	Gaf domain
ID12_RS09450	COG4585	Histidine kinase
ID12_RS09455	COG2197	response regulator
ID12_RS09470	COG0753	catalase activity
ID12_RS09475	COG1959	2 iron, 2 sulfur cluster binding
ID12_RS09480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ID12_RS09480	COG1017	nitric oxide dioxygenase activity
ID12_RS09485	COG2719	SpoVR family
ID12_RS09490	COG1785	Belongs to the alkaline phosphatase family
ID12_RS09495	COG1388	LysM domain
ID12_RS09495	COG0791	NLP P60 protein
ID12_RS09500	COG0531	amino acid
ID12_RS09515	COG1595	DNA-templated transcription, initiation
ID12_RS09520	COG0204	Acyl-transferase
ID12_RS09525	COG1253	flavin adenine dinucleotide binding
ID12_RS09530	COG0789	Transcriptional regulator
ID12_RS09535	COG1253	flavin adenine dinucleotide binding
ID12_RS09550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ID12_RS09555	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_RS09560	COG0668	transmembrane transport
ID12_RS09565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ID12_RS09570	COG0726	polysaccharide deacetylase
ID12_RS09575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_RS09580	COG0589	response to stress
ID12_RS09585	COG1132	(ABC) transporter
ID12_RS09590	COG1132	(ABC) transporter
ID12_RS09605	COG0702	epimerase
ID12_RS09615	COG3842	ATPase activity
ID12_RS09620	COG2508	Transcriptional regulator
ID12_RS09630	COG0189	ligase activity
ID12_RS09635	COG0189	ligase activity
ID12_RS09640	COG4399	Belongs to the UPF0754 family
ID12_RS09645	COG3679	Belongs to the UPF0342 family
ID12_RS09650	COG0561	phosphatase activity
ID12_RS09655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID12_RS09665	COG0475	glutathione-regulated potassium exporter activity
ID12_RS09670	COG0490	domain, Protein
ID12_RS09680	COG1024	Enoyl-CoA hydratase
ID12_RS09690	COG0420	3'-5' exonuclease activity
ID12_RS09695	COG4717	serine-type aminopeptidase activity
ID12_RS09700	COG3481	metal-dependent phosphohydrolase, HD sub domain
ID12_RS09710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID12_RS09730	COG1846	Transcriptional regulator
ID12_RS09735	COG4980	gas vesicle protein
ID12_RS09750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ID12_RS09755	COG0537	adenosine 5'-monophosphoramidase activity
ID12_RS09760	COG1131	(ABC) transporter
ID12_RS09765	COG4473	ABC transporter
ID12_RS09775	COG1473	amidohydrolase
ID12_RS09785	COG2329	Antibiotic biosynthesis monooxygenase
ID12_RS09790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_RS09795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ID12_RS09800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ID12_RS09805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ID12_RS09810	COG1309	transcriptional regulator
ID12_RS09815	COG1511	domain protein
ID12_RS09820	COG1363	Peptidase, m42
ID12_RS09825	COG1301	dicarboxylic acid transport
ID12_RS09830	COG1234	tRNA 3'-trailer cleavage
ID12_RS09835	COG0095	Lipoate-protein ligase
ID12_RS09840	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS09850	COG0501	Belongs to the peptidase M48B family
ID12_RS09855	COG1404	Belongs to the peptidase S8 family
ID12_RS09860	COG0406	alpha-ribazole phosphatase activity
ID12_RS09865	COG0840	transmembrane signaling receptor activity
ID12_RS09870	COG0723	plastoquinol--plastocyanin reductase activity
ID12_RS09870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ID12_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS09885	COG4903	ComK protein
ID12_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS09905	COG2814	Major facilitator Superfamily
ID12_RS09910	COG2732	(Barnase) inhibitor
ID12_RS09915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_RS09920	COG4605	iron ion homeostasis
ID12_RS09925	COG4604	ABC transporter, ATP-binding protein
ID12_RS09930	COG4607	ABC-type enterochelin transport system periplasmic component
ID12_RS09935	COG1316	TRANSCRIPTIONal
ID12_RS09950	COG0398	Pfam SNARE associated Golgi protein
ID12_RS09955	COG0681	Belongs to the peptidase S26 family
ID12_RS09960	COG3180	Ammonia monooxygenase
ID12_RS09975	COG2259	Doxx family
ID12_RS09980	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ID12_RS09985	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ID12_RS09990	COG1074	ATP-dependent DNA helicase activity
ID12_RS09995	COG0420	3'-5' exonuclease activity
ID12_RS10000	COG0419	ATPase involved in DNA repair
ID12_RS10005	COG1403	HNH endonuclease
ID12_RS10045	COG5337	Spore coat protein CotH
ID12_RS10060	COG0179	Fumarylacetoacetate (FAA) hydrolase
ID12_RS10075	COG0367	asparagine synthase
ID12_RS10090	COG1562	ergosterol biosynthetic process
ID12_RS10095	COG0534	Mate efflux family protein
ID12_RS10100	COG1917	Cupin 2, conserved barrel domain protein
ID12_RS10100	COG2207	Transcriptional regulator
ID12_RS10125	COG0076	glutamate decarboxylase activity
ID12_RS10160	COG1410	methionine synthase
ID12_RS10160	COG0646	methionine synthase
ID12_RS10165	COG0646	methionine synthase
ID12_RS10165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ID12_RS10170	COG1666	GTP binding
ID12_RS10175	COG2996	Protein conserved in bacteria
ID12_RS10180	COG1744	ABC transporter substrate-binding protein PnrA-like
ID12_RS10185	COG0840	transmembrane signaling receptor activity
ID12_RS10190	COG1307	EDD domain protein, DegV family
ID12_RS10195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_RS10215	COG0561	phosphatase activity
ID12_RS10220	COG1073	alpha beta
ID12_RS10225	COG2151	metal-sulfur cluster biosynthetic enzyme
ID12_RS10230	COG0277	FAD linked oxidase domain protein
ID12_RS10235	COG2271	Major facilitator Superfamily
ID12_RS10240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ID12_RS10245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ID12_RS10250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ID12_RS10255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID12_RS10260	COG0505	Belongs to the CarA family
ID12_RS10265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID12_RS10270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ID12_RS10280	COG2814	Major facilitator Superfamily
ID12_RS10290	COG2267	carboxylic ester hydrolase activity
ID12_RS10300	COG1744	ABC transporter substrate-binding protein PnrA-like
ID12_RS10315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID12_RS10320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID12_RS10325	COG5504	Zn-dependent protease
ID12_RS10330	COG0444	Belongs to the ABC transporter superfamily
ID12_RS10335	COG4608	Belongs to the ABC transporter superfamily
ID12_RS10345	COG0601	transmembrane transport
ID12_RS10350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_RS10355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID12_RS10390	COG0180	Tryptophanyl-tRNA synthetase
ID12_RS10395	COG4166	transmembrane transport
ID12_RS10400	COG0601	transmembrane transport
ID12_RS10405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_RS10410	COG0444	Belongs to the ABC transporter superfamily
ID12_RS10415	COG4608	Belongs to the ABC transporter superfamily
ID12_RS10425	COG0456	acetyltransferase
ID12_RS10430	COG1393	Belongs to the ArsC family
ID12_RS10435	COG0861	Integral membrane protein TerC family
ID12_RS10440	COG4862	establishment of competence for transformation
ID12_RS10445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_RS10455	COG1164	Oligoendopeptidase f
ID12_RS10460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ID12_RS10465	COG2346	COG2346, Truncated hemoglobins
ID12_RS10470	COG0741	lytic transglycosylase activity
ID12_RS10475	COG4116	CYTH
ID12_RS10485	COG2357	RelA SpoT domain protein
ID12_RS10490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID12_RS10495	COG0564	pseudouridine synthase activity
ID12_RS10500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ID12_RS10505	COG0569	domain protein
ID12_RS10505	COG0475	glutathione-regulated potassium exporter activity
ID12_RS10510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ID12_RS10515	COG0352	thiamine-phosphate diphosphorylase activity
ID12_RS10525	COG2104	thiamine diphosphate biosynthetic process
ID12_RS10530	COG2022	thiamine diphosphate biosynthetic process
ID12_RS10535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID12_RS10540	COG0351	phosphomethylpyrimidine kinase
ID12_RS10545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ID12_RS10595	COG0210	DNA helicase
ID12_RS10605	COG2153	protein acetylation
ID12_RS10610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ID12_RS10615	COG2382	esterase
ID12_RS10620	COG0626	cystathionine gamma-synthase activity
ID12_RS10625	COG0626	cystathionine gamma-synthase activity
ID12_RS10635	COG0825	malonyl-CoA metabolic process
ID12_RS10650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_RS10675	COG0300	oxidoreductase activity
ID12_RS10690	COG3173	Aminoglycoside phosphotransferase
ID12_RS10695	COG0583	DNA-binding transcription factor activity
ID12_RS10710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS10715	COG0583	DNA-binding transcription factor activity
ID12_RS10720	COG2807	transmembrane transport
ID12_RS10745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ID12_RS10765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_RS10770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_RS10790	COG4195	phage-related replication protein
ID12_RS10795	COG2856	Zn peptidase
ID12_RS10800	COG3409	Peptidoglycan-binding domain 1 protein
ID12_RS10800	COG5632	N-Acetylmuramoyl-L-alanine amidase
ID12_RS10815	COG0306	phosphate transporter
ID12_RS10820	COG1392	Phosphate transport regulator
ID12_RS10830	COG0405	Gamma-glutamyltransferase
ID12_RS10835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ID12_RS10845	COG4208	sulfate ABC transporter
ID12_RS10850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ID12_RS10860	COG3775	system Galactitol-specific IIC component
ID12_RS10875	COG1063	alcohol dehydrogenase
ID12_RS10880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_RS10885	COG0022	dehydrogenase e1 component
ID12_RS10885	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_RS10890	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_RS10895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS10910	COG2390	Transcriptional regulator
ID12_RS10920	COG0531	amino acid
ID12_RS10925	COG0346	lactoylglutathione lyase activity
ID12_RS10930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_RS10935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_RS10940	COG2362	D-Aminopeptidase
ID12_RS10945	COG0601	transmembrane transport
ID12_RS10950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_RS10955	COG0444	Belongs to the ABC transporter superfamily
ID12_RS10960	COG4166	transmembrane transport
ID12_RS10970	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_RS10975	COG4948	Mandelate Racemase Muconate Lactonizing
ID12_RS10980	COG0791	NLP P60 protein
ID12_RS10985	COG4608	Belongs to the ABC transporter superfamily
ID12_RS10990	COG1834	amidinotransferase
ID12_RS10995	COG1607	acyl-coa hydrolase
ID12_RS11000	COG1695	Transcriptional regulator
ID12_RS11015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS11025	COG2076	Multidrug Resistance protein
ID12_RS11030	COG2076	Multidrug Resistance protein
ID12_RS11040	COG0788	formyltetrahydrofolate deformylase activity
ID12_RS11045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ID12_RS11050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ID12_RS11055	COG0457	Tetratricopeptide repeat
ID12_RS11065	COG1764	response to oxidative stress
ID12_RS11070	COG1846	Transcriptional regulator
ID12_RS11075	COG1764	response to oxidative stress
ID12_RS11080	COG0590	tRNA wobble adenosine to inosine editing
ID12_RS11085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ID12_RS11090	COG1404	Belongs to the peptidase S8 family
ID12_RS11105	COG0745	RESPONSE REGULATOR receiver
ID12_RS11110	COG5002	protein histidine kinase activity
ID12_RS11110	COG3850	Histidine kinase
ID12_RS11115	COG3212	peptidase
ID12_RS11120	COG3212	peptidase
ID12_RS11130	COG2239	Acts as a magnesium transporter
ID12_RS11140	COG0583	DNA-binding transcription factor activity
ID12_RS11150	COG0789	Transcriptional regulator
ID12_RS11165	COG1846	Transcriptional regulator
ID12_RS11170	COG5001	Diguanylate cyclase
ID12_RS11170	COG3300	MHYT domain
ID12_RS11175	COG0586	Pfam SNARE associated Golgi protein
ID12_RS11180	COG0861	Integral membrane protein TerC family
ID12_RS11185	COG1191	sigma factor activity
ID12_RS11205	COG0501	Belongs to the peptidase M48B family
ID12_RS11210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ID12_RS11215	COG2323	membrane
ID12_RS11225	COG3594	Acyltransferase
ID12_RS11230	COG5002	protein histidine kinase activity
ID12_RS11235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ID12_RS11240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ID12_RS11245	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ID12_RS11250	COG0436	Aminotransferase
ID12_RS11255	COG1850	ribulose-bisphosphate carboxylase activity
ID12_RS11260	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ID12_RS11265	COG0235	Class ii aldolase
ID12_RS11270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ID12_RS11280	COG3852	Histidine kinase
ID12_RS11285	COG1846	Transcriptional regulator
ID12_RS11290	COG1360	Flagellar Motor Protein
ID12_RS11295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ID12_RS11300	COG0542	response to heat
ID12_RS11305	COG3949	Membrane
ID12_RS11310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ID12_RS11315	COG0720	synthase
ID12_RS11320	COG0602	queuosine metabolic process
ID12_RS11325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ID12_RS11340	COG4873	Protein conserved in bacteria
ID12_RS11350	COG3773	Cell wall hydrolase
ID12_RS11355	COG2244	polysaccharide biosynthetic process
ID12_RS11360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS11365	COG2217	Heavy metal translocating P-type atpase
ID12_RS11370	COG0006	proline dipeptidase activity
ID12_RS11375	COG1609	Transcriptional regulator
ID12_RS11380	COG3711	transcriptional antiterminator
ID12_RS11385	COG2190	(PTS) system
ID12_RS11385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS11385	COG1263	PTS System
ID12_RS11390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS11395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ID12_RS11405	COG1533	DNA photolyase activity
ID12_RS11410	COG0840	transmembrane signaling receptor activity
ID12_RS11420	COG2084	Dehydrogenase
ID12_RS11425	COG2340	Cysteine-rich secretory protein family
ID12_RS11430	COG0768	penicillin binding
ID12_RS11435	COG4191	Histidine kinase
ID12_RS11440	COG0436	Aminotransferase
ID12_RS11445	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ID12_RS11450	COG1714	RDD family
ID12_RS11460	COG0784	Response regulator, receiver
ID12_RS11460	COG0835	chemotaxis
ID12_RS11475	COG2814	Major facilitator Superfamily
ID12_RS11480	COG1376	ErfK ybiS ycfS ynhG family protein
ID12_RS11485	COG1408	metallophosphoesterase
ID12_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS11495	COG2200	EAL domain
ID12_RS11500	COG3546	catalase activity
ID12_RS11505	COG4703	Protein of unknown function (DUF1797)
ID12_RS11510	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ID12_RS11520	COG0517	IMP dehydrogenase activity
ID12_RS11525	COG0583	DNA-binding transcription factor activity
ID12_RS11535	COG0716	FMN binding
ID12_RS11545	COG0716	FMN binding
ID12_RS11550	COG2171	N-acyltransferase activity
ID12_RS11555	COG1473	amidohydrolase
ID12_RS11565	COG0668	transmembrane transport
ID12_RS11570	COG0450	alkyl hydroperoxide reductase
ID12_RS11575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS11590	COG0746	molybdenum cofactor guanylyltransferase activity
ID12_RS11595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID12_RS11600	COG0303	'Molybdopterin
ID12_RS11605	COG1763	Mo-molybdopterin cofactor biosynthetic process
ID12_RS11610	COG0314	molybdopterin synthase activity
ID12_RS11615	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ID12_RS11630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID12_RS11635	COG1136	(ABC) transporter
ID12_RS11640	COG0577	efflux transmembrane transporter activity
ID12_RS11645	COG1349	DNA-binding transcription factor activity
ID12_RS11650	COG1105	Belongs to the carbohydrate kinase PfkB family
ID12_RS11655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS11655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS11655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS11660	COG0681	Belongs to the peptidase S26 family
ID12_RS11670	COG0488	(ABC) transporter
ID12_RS11685	COG2309	aminopeptidase activity
ID12_RS11690	COG1077	Cell shape determining protein MreB Mrl
ID12_RS11695	COG2002	toxin-antitoxin pair type II binding
ID12_RS11700	COG3852	Histidine kinase
ID12_RS11705	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ID12_RS11705	COG2105	PFAM AIG2 family protein
ID12_RS11710	COG0569	domain protein
ID12_RS11715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID12_RS11720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ID12_RS11725	COG5503	Protein of unknown function (DUF1447)
ID12_RS11730	COG0561	phosphatase activity
ID12_RS11735	COG0242	peptide deformylase activity
ID12_RS11750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_RS11755	COG0022	dehydrogenase e1 component
ID12_RS11760	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_RS11765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_RS11770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS11775	COG1982	Orn Lys Arg decarboxylase major
ID12_RS11780	COG4476	Belongs to the UPF0223 family
ID12_RS11785	COG4493	Belongs to the UPF0637 family
ID12_RS11795	COG0483	inositol monophosphate 1-phosphatase activity
ID12_RS11810	COG1595	DNA-templated transcription, initiation
ID12_RS11830	COG1217	gtp-binding protein TYPA
ID12_RS11840	COG4896	Protein conserved in bacteria
ID12_RS11850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ID12_RS11855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ID12_RS11860	COG2066	Belongs to the glutaminase family
ID12_RS11865	COG4838	Belongs to the UPF0358 family
ID12_RS11870	COG0772	Belongs to the SEDS family
ID12_RS11875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ID12_RS11880	COG0415	Belongs to the DNA photolyase family
ID12_RS11885	COG1612	heme a metabolic process
ID12_RS11890	COG0109	protoheme IX farnesyltransferase activity
ID12_RS11895	COG2010	Cytochrome c
ID12_RS11895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ID12_RS11900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ID12_RS11905	COG1845	cytochrome c oxidase, subunit III
ID12_RS11910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ID12_RS11915	COG3336	cytochrome c oxidase
ID12_RS11925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ID12_RS11930	COG2340	Cysteine-rich secretory protein family
ID12_RS11950	COG3679	Belongs to the UPF0342 family
ID12_RS11955	COG4471	UPF0298 protein
ID12_RS11960	COG0742	ribosomal rna small subunit methyltransferase
ID12_RS11965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ID12_RS11970	COG3314	Sporulation integral membrane protein YlbJ
ID12_RS11975	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID12_RS11980	COG3480	Lon protease (S16) C-terminal proteolytic domain
ID12_RS11990	COG1399	metal-binding, possibly nucleic acid-binding protein
ID12_RS11995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ID12_RS12005	COG0454	-acetyltransferase
ID12_RS12010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ID12_RS12015	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ID12_RS12020	COG2001	Belongs to the MraZ family
ID12_RS12025	COG0275	rRNA processing
ID12_RS12030	COG4839	cell division protein FtsL
ID12_RS12035	COG0768	penicillin binding
ID12_RS12040	COG0768	penicillin binding
ID12_RS12045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ID12_RS12050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID12_RS12055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID12_RS12060	COG0772	Belongs to the SEDS family
ID12_RS12065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID12_RS12070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ID12_RS12075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ID12_RS12080	COG3879	Bacterial protein of unknown function (DUF881)
ID12_RS12085	COG3879	Bacterial protein of unknown function (DUF881)
ID12_RS12090	COG3856	small basic protein
ID12_RS12095	COG0849	cell division
ID12_RS12100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ID12_RS12105	COG1404	Belongs to the peptidase S8 family
ID12_RS12105	COG4412	M6 family metalloprotease domain protein
ID12_RS12115	COG1191	sigma factor activity
ID12_RS12120	COG1191	sigma factor activity
ID12_RS12125	COG2390	Transcriptional regulator
ID12_RS12140	COG3730	PTS system glucitol sorbitol-specific
ID12_RS12145	COG3732	PTS system glucitol sorbitol-specific
ID12_RS12155	COG1119	ATPase activity
ID12_RS12160	COG1873	PFAM PRC-barrel domain
ID12_RS12165	COG1496	oxidoreductase activity
ID12_RS12170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ID12_RS12175	COG1799	cell septum assembly
ID12_RS12180	COG0762	integral membrane protein
ID12_RS12185	COG2302	S4 RNA-binding domain
ID12_RS12190	COG3599	regulation of cell shape
ID12_RS12195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ID12_RS12200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID12_RS12205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ID12_RS12210	COG0564	pseudouridine synthase activity
ID12_RS12215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ID12_RS12220	COG2233	PERMEase
ID12_RS12225	COG0540	Belongs to the ATCase OTCase family
ID12_RS12230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID12_RS12235	COG0505	Belongs to the CarA family
ID12_RS12240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID12_RS12245	COG0543	2 iron, 2 sulfur cluster binding
ID12_RS12250	COG0167	dihydroorotate dehydrogenase activity
ID12_RS12255	COG0284	orotidine-5'-phosphate decarboxylase activity
ID12_RS12260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ID12_RS12265	COG0175	sulfate reduction
ID12_RS12270	COG0306	phosphate transporter
ID12_RS12275	COG2046	Belongs to the sulfate adenylyltransferase family
ID12_RS12280	COG0529	Catalyzes the synthesis of activated sulfate
ID12_RS12285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ID12_RS12290	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ID12_RS12295	COG1648	precorrin-2 dehydrogenase activity
ID12_RS12305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ID12_RS12310	COG1561	YicC-like family, N-terminal region
ID12_RS12315	COG2052	Domain of unknown function (DUF370)
ID12_RS12320	COG0194	GDP metabolic process
ID12_RS12325	COG1758	RNA polymerase activity
ID12_RS12330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ID12_RS12335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ID12_RS12340	COG0242	peptide deformylase activity
ID12_RS12345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ID12_RS12350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID12_RS12350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID12_RS12355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ID12_RS12360	COG0631	protein serine/threonine phosphatase activity
ID12_RS12365	COG2815	serine threonine protein kinase
ID12_RS12365	COG0515	serine threonine protein kinase
ID12_RS12370	COG1162	GTPase activity
ID12_RS12375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID12_RS12380	COG1564	THIamine pyrophosphokinase
ID12_RS12390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ID12_RS12395	COG1302	Protein conserved in bacteria
ID12_RS12400	COG1461	Dihydroxyacetone kinase
ID12_RS12405	COG1760	l-serine dehydratase
ID12_RS12410	COG1760	l-serine dehydratase
ID12_RS12415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ID12_RS12420	COG1349	DNA-binding transcription factor activity
ID12_RS12425	COG0416	fatty acid biosynthetic process
ID12_RS12430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ID12_RS12435	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS12440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID12_RS12450	COG1196	nuclear chromosome segregation
ID12_RS12455	COG0552	protein localization to endoplasmic reticulum
ID12_RS12460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ID12_RS12465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ID12_RS12470	COG0228	four-way junction DNA binding
ID12_RS12475	COG1837	Belongs to the UPF0109 family
ID12_RS12485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ID12_RS12490	COG0336	Belongs to the RNA methyltransferase TrmD family
ID12_RS12495	COG0335	large ribosomal subunit rRNA binding
ID12_RS12500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ID12_RS12505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID12_RS12515	COG2257	FlhB HrpN YscU SpaS Family
ID12_RS12520	COG0045	succinate-CoA ligase (ADP-forming) activity
ID12_RS12525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ID12_RS12530	COG0758	DNA mediated transformation
ID12_RS12535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ID12_RS12540	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ID12_RS12545	COG4974	Belongs to the 'phage' integrase family
ID12_RS12550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ID12_RS12555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ID12_RS12560	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ID12_RS12565	COG1815	bacterial-type flagellum-dependent cell motility
ID12_RS12570	COG1558	bacterial-type flagellum-dependent cell motility
ID12_RS12575	COG1677	Flagellar hook-basal body complex protein FliE
ID12_RS12580	COG1766	The M ring may be actively involved in energy transduction
ID12_RS12585	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_RS12590	COG1317	bacterial-type flagellum organization
ID12_RS12595	COG1157	protein secretion by the type III secretion system
ID12_RS12600	COG2882	bacterial-type flagellum organization
ID12_RS12605	COG3334	PFAM MgtE intracellular
ID12_RS12610	COG3144	bacterial-type flagellum assembly
ID12_RS12615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ID12_RS12620	COG4786	Flagellar basal body rod
ID12_RS12625	COG1582	Flagellar protein (FlbD)
ID12_RS12630	COG1580	Controls the rotational direction of flagella during chemotaxis
ID12_RS12635	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_RS12640	COG1776	CheC inhibitor of MCP methylation
ID12_RS12640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_RS12645	COG2201	protein-glutamate methylesterase activity
ID12_RS12650	COG3190	flagellar
ID12_RS12655	COG1338	Plays a role in the flagellum-specific transport system
ID12_RS12660	COG1987	bacterial-type flagellum assembly
ID12_RS12665	COG1684	flagellar biosynthetic protein fliR
ID12_RS12670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ID12_RS12675	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ID12_RS12680	COG1419	protein localization to endoplasmic reticulum
ID12_RS12685	COG0455	bacterial-type flagellum organization
ID12_RS12690	COG2201	protein-glutamate methylesterase activity
ID12_RS12695	COG2198	Histidine kinase
ID12_RS12695	COG0643	Histidine kinase
ID12_RS12700	COG0835	chemotaxis
ID12_RS12705	COG1776	CheC inhibitor of MCP methylation
ID12_RS12715	COG1191	sigma factor activity
ID12_RS12730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ID12_RS12735	COG0528	UMP kinase activity
ID12_RS12740	COG0233	cytoplasmic translational termination
ID12_RS12745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ID12_RS12750	COG4589	Belongs to the CDS family
ID12_RS12755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ID12_RS12760	COG0750	zinc metalloprotease
ID12_RS12765	COG0442	prolyl-tRNA aminoacylation
ID12_RS12770	COG2176	DNA-directed DNA polymerase activity
ID12_RS12785	COG3693	PFAM glycoside hydrolase, family 10
ID12_RS12795	COG0779	Required for maturation of 30S ribosomal subunits
ID12_RS12800	COG0195	Participates in both transcription termination and antitermination
ID12_RS12805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ID12_RS12810	COG1358	cellular component organization or biogenesis
ID12_RS12815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ID12_RS12820	COG1550	Protein conserved in bacteria
ID12_RS12825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ID12_RS12830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ID12_RS12835	COG0196	riboflavin kinase activity
ID12_RS12840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ID12_RS12845	COG1185	polyribonucleotide nucleotidyltransferase activity
ID12_RS12850	COG0726	polysaccharide deacetylase
ID12_RS12855	COG0612	Peptidase, M16
ID12_RS12865	COG1873	PFAM PRC-barrel domain
ID12_RS12870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_RS12875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ID12_RS12880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ID12_RS12885	COG0527	aspartate kinase activity
ID12_RS12895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ID12_RS12900	COG0740	serine-type endopeptidase activity
ID12_RS12910	COG1674	ftsk spoiiie
ID12_RS12910	COG4980	gas vesicle protein
ID12_RS12915	COG2188	Transcriptional regulator
ID12_RS12920	COG2814	Major facilitator Superfamily
ID12_RS12925	COG2409	Drug exporters of the RND superfamily
ID12_RS12925	COG1033	growth of symbiont in host cell
ID12_RS12930	COG0612	Peptidase, M16
ID12_RS12935	COG0612	Peptidase, M16
ID12_RS12945	COG1033	growth of symbiont in host cell
ID12_RS12945	COG2409	Drug exporters of the RND superfamily
ID12_RS12950	COG0300	oxidoreductase activity
ID12_RS12965	COG1426	Protein conserved in bacteria
ID12_RS12970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ID12_RS12975	COG1546	Belongs to the CinA family
ID12_RS12975	COG1058	Belongs to the CinA family
ID12_RS12980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ID12_RS12985	COG1418	mRNA catabolic process
ID12_RS12990	COG1692	metallophosphoesterase
ID12_RS12995	COG2359	stage V sporulation protein S
ID12_RS13000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID12_RS13005	COG1063	alcohol dehydrogenase
ID12_RS13010	COG0156	8-amino-7-oxononanoate synthase activity
ID12_RS13020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID12_RS13025	COG4550	Control of competence regulator ComK, YlbF/YmcA
ID12_RS13035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID12_RS13040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ID12_RS13060	COG1329	Transcriptional regulator
ID12_RS13065	COG4195	phage-related replication protein
ID12_RS13070	COG0457	Tetratricopeptide repeat
ID12_RS13075	COG1404	Belongs to the peptidase S8 family
ID12_RS13080	COG4195	phage-related replication protein
ID12_RS13085	COG1764	response to oxidative stress
ID12_RS13115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ID12_RS13120	COG1923	regulation of RNA biosynthetic process
ID12_RS13135	COG1780	Probably involved in ribonucleotide reductase function
ID12_RS13140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID12_RS13145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID12_RS13150	COG4112	unkown
ID12_RS13160	COG0464	growth
ID12_RS13165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ID12_RS13170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ID12_RS13175	COG0789	Transcriptional regulator
ID12_RS13180	COG0174	glutamine synthetase
ID12_RS13215	COG0457	Tetratricopeptide repeat
ID12_RS13230	COG0604	alcohol dehydrogenase
ID12_RS13240	COG5444	nuclease activity
ID12_RS13265	COG5646	InterPro IPR014922
ID12_RS13290	COG0457	Tetratricopeptide repeat
ID12_RS13300	COG3619	membrane
ID12_RS13305	COG3285	dna ligase
ID12_RS13305	COG1793	dna ligase
ID12_RS13310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ID12_RS13315	COG4876	unkown
ID12_RS13325	COG1959	2 iron, 2 sulfur cluster binding
ID12_RS13330	COG0702	epimerase
ID12_RS13340	COG0247	lactate metabolic process
ID12_RS13345	COG1139	Iron-sulfur cluster binding protein
ID12_RS13350	COG1556	Lactate utilization protein
ID12_RS13370	COG2323	membrane
ID12_RS13375	COG1309	transcriptional regulator
ID12_RS13380	COG2124	cytochrome p450
ID12_RS13380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ID12_RS13385	COG3591	Belongs to the peptidase S1B family
ID12_RS13390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID12_RS13395	COG3209	COG3209 Rhs family protein
ID12_RS13400	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS13415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ID12_RS13420	COG1388	LysM domain
ID12_RS13425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ID12_RS13430	COG4224	UPF0291 protein
ID12_RS13435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ID12_RS13445	COG3763	UPF0154 protein
ID12_RS13455	COG0785	Cytochrome C biogenesis protein
ID12_RS13460	COG4846	Membrane protein involved in cytochrome C biogenesis
ID12_RS13470	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_RS13485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ID12_RS13490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS13505	COG0824	Thioesterase
ID12_RS13515	COG4841	protein insertion into membrane
ID12_RS13520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ID12_RS13525	COG1832	CoA-binding protein
ID12_RS13530	COG0187	DNA topoisomerase II activity
ID12_RS13535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID12_RS13545	COG0738	Major facilitator superfamily
ID12_RS13550	COG0473	3-isopropylmalate dehydrogenase activity
ID12_RS13555	COG0110	maltose O-acetyltransferase activity
ID12_RS13560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_RS13565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ID12_RS13570	COG0640	Transcriptional regulator
ID12_RS13585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ID12_RS13590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_RS13600	COG1309	transcriptional regulator
ID12_RS13605	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_RS13610	COG1733	regulation of RNA biosynthetic process
ID12_RS13615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_RS13620	COG0251	oxidation-reduction process
ID12_RS13655	COG0657	acetylesterase activity
ID12_RS13660	COG0789	Transcriptional regulator
ID12_RS13665	COG2723	6-phospho-beta-galactosidase activity
ID12_RS13670	COG1263	PTS System
ID12_RS13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_RS13670	COG2190	(PTS) system
ID12_RS13685	COG2205	protein histidine kinase activity
ID12_RS13690	COG0745	RESPONSE REGULATOR receiver
ID12_RS13700	COG3507	Belongs to the glycosyl hydrolase 43 family
ID12_RS13705	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS13710	COG1486	melibiose metabolic process
ID12_RS13715	COG0395	ABC-type sugar transport system, permease component
ID12_RS13720	COG1175	transmembrane transport
ID12_RS13725	COG1653	transport
ID12_RS13730	COG1609	Transcriptional regulator
ID12_RS13735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID12_RS13750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS13760	COG0456	acetyltransferase
ID12_RS13765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS13795	COG1846	Transcriptional regulator
ID12_RS13800	COG2814	Major facilitator Superfamily
ID12_RS13810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS13810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS13810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS13815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_RS13815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS13815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_RS13820	COG1105	Belongs to the carbohydrate kinase PfkB family
ID12_RS13830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_RS13865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ID12_RS13880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID12_RS13885	COG1024	Enoyl-CoA hydratase
ID12_RS13895	COG0511	ligase activity, forming carbon-carbon bonds
ID12_RS13900	COG0439	Biotin carboxylase
ID12_RS13905	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS13910	COG1960	acyl-CoA dehydrogenase activity
ID12_RS13915	COG1649	PFAM Uncharacterised BCR, COG1649
ID12_RS13920	COG2365	Tyrosine phosphatase family
ID12_RS13925	COG1349	DNA-binding transcription factor activity
ID12_RS13930	COG1942	4-Oxalocrotonate Tautomerase
ID12_RS13940	COG3835	regulator
ID12_RS13945	COG0277	FAD linked oxidase domain protein
ID12_RS13950	COG0247	lactate metabolic process
ID12_RS13970	COG0166	Belongs to the GPI family
ID12_RS13975	COG2246	polysaccharide biosynthetic process
ID12_RS13980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ID12_RS13985	COG0586	Pfam SNARE associated Golgi protein
ID12_RS13990	COG1587	Uroporphyrinogen-III synthase
ID12_RS14000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_RS14015	COG0534	Mate efflux family protein
ID12_RS14020	COG2027	D-alanyl-D-alanine carboxypeptidase
ID12_RS14025	COG4677	pectinesterase activity
ID12_RS14030	COG2323	membrane
ID12_RS14035	COG2146	nitrite reductase [NAD(P)H] activity
ID12_RS14040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID12_RS14045	COG0243	molybdopterin cofactor binding
ID12_RS14050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID12_RS14055	COG2223	nitrite transmembrane transporter activity
ID12_RS14060	COG0493	'glutamate synthase
ID12_RS14065	COG0070	glutamate synthase
ID12_RS14065	COG0067	glutamate synthase
ID12_RS14065	COG0069	glutamate synthase activity
ID12_RS14070	COG0583	DNA-binding transcription factor activity
ID12_RS14080	COG1132	(ABC) transporter
ID12_RS14085	COG0789	Transcriptional regulator
ID12_RS14085	COG4978	Transcriptional regulator
ID12_RS14090	COG0454	-acetyltransferase
ID12_RS14095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ID12_RS14100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ID12_RS14105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_RS14115	COG0243	molybdopterin cofactor binding
ID12_RS14125	COG1070	Carbohydrate kinase
ID12_RS14130	COG2115	Belongs to the xylose isomerase family
ID12_RS14135	COG1940	carbohydrate kinase activity
ID12_RS14145	COG2211	Major facilitator Superfamily
ID12_RS14150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_RS14155	COG1994	Peptidase M50
ID12_RS14175	COG1309	transcriptional regulator
ID12_RS14180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_RS14185	COG3708	Transcriptional regulator
ID12_RS14190	COG2378	regulation of single-species biofilm formation
ID12_RS14200	COG0640	Transcriptional regulator
ID12_RS14205	COG0531	amino acid
ID12_RS14210	COG0741	lytic transglycosylase activity
ID12_RS14215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ID12_RS14220	COG2079	MmgE PrpD family protein
ID12_RS14225	COG0372	Belongs to the citrate synthase family
ID12_RS14230	COG2322	membrane
ID12_RS14240	COG3584	3D domain protein
ID12_RS14240	COG1388	LysM domain
ID12_RS14245	COG0514	ATP-dependent DNA helicase (RecQ)
ID12_RS14250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID12_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
ID12_RS14275	COG1657	PFAM Prenyltransferase squalene oxidase
ID12_RS14280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ID12_RS14285	COG0385	Bile acid
ID12_RS14290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_RS14295	COG0567	Dehydrogenase, E1 component
ID12_RS14300	COG4548	von Willebrand factor, type A
ID12_RS14305	COG0714	Associated with various cellular activities
ID12_RS14310	COG2032	superoxide dismutase activity
ID12_RS14315	COG1388	LysM domain
ID12_RS14315	COG0791	NLP P60 protein
ID12_RS14320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID12_RS14325	COG0534	Mate efflux family protein
ID12_RS14330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_RS14335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_RS14345	COG2962	Rard protein
ID12_RS14360	COG1733	regulation of RNA biosynthetic process
ID12_RS14365	COG0778	Nitroreductase
ID12_RS14375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_RS14380	COG3409	Peptidoglycan-binding domain 1 protein
ID12_RS14380	COG0793	Belongs to the peptidase S41A family
ID12_RS14385	COG2226	methyltransferase
ID12_RS14395	COG1876	peptidase activity
ID12_RS14400	COG0813	purine-nucleoside phosphorylase activity
ID12_RS14410	COG0671	phosphoesterase, PA-phosphatase related
ID12_RS14420	COG4479	Belongs to the UPF0346 family
ID12_RS14430	COG1509	lysine 2,3-aminomutase activity
ID12_RS14435	COG3829	transcription factor binding
ID12_RS14440	COG0463	Glycosyl transferase, family 2
ID12_RS14455	COG4641	Protein conserved in bacteria
ID12_RS14465	COG1086	Polysaccharide biosynthesis protein
ID12_RS14470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID12_RS14475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID12_RS14480	COG1846	Transcriptional regulator
ID12_RS14500	COG4698	Protein conserved in bacteria
ID12_RS14505	COG2755	lipolytic protein G-D-S-L family
ID12_RS14510	COG1999	signal sequence binding
ID12_RS14525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ID12_RS14530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ID12_RS14535	COG1272	protein, Hemolysin III
ID12_RS14540	COG0204	Acyl-transferase
ID12_RS14545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID12_RS14550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ID12_RS14555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ID12_RS14565	COG2136	Putative SAM-dependent methyltransferase
ID12_RS14565	COG2521	methyltransferase
ID12_RS14575	COG0129	dihydroxy-acid dehydratase activity
ID12_RS14580	COG1413	lyase activity
ID12_RS14585	COG1418	mRNA catabolic process
ID12_RS14590	COG0386	Belongs to the glutathione peroxidase family
ID12_RS14595	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ID12_RS14600	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ID12_RS14605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID12_RS14615	COG1278	Cold shock
ID12_RS14630	COG0328	RNA-DNA hybrid ribonuclease activity
ID12_RS14635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ID12_RS14640	COG0328	RNA-DNA hybrid ribonuclease activity
ID12_RS14650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_RS14660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ID12_RS14665	COG1755	Isoprenylcysteine carboxyl methyltransferase
ID12_RS14670	COG3424	synthase
ID12_RS14675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ID12_RS14680	COG0726	polysaccharide deacetylase
ID12_RS14685	COG2233	PERMEase
ID12_RS14690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_RS14695	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ID12_RS14700	COG1199	ATP-dependent helicase activity
ID12_RS14710	COG0116	Belongs to the methyltransferase superfamily
ID12_RS14715	COG3599	regulation of cell shape
ID12_RS14720	COG4474	Belongs to the UPF0398 family
ID12_RS14725	COG3359	exonuclease
ID12_RS14730	COG1111	helicase
ID12_RS14730	COG1205	dead DEAH box helicase
ID12_RS14735	COG1902	pentaerythritol trinitrate reductase activity
ID12_RS14740	COG2190	(PTS) system
ID12_RS14745	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_RS14775	COG3331	DNA recombination
ID12_RS14780	COG4499	WXG100 protein secretion system (Wss), protein YukC
ID12_RS14780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_RS14790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ID12_RS14795	COG3935	DnaD domain protein
ID12_RS14800	COG0017	Asparaginyl-tRNA synthetase
ID12_RS14805	COG5353	protein conserved in bacteria
ID12_RS14810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ID12_RS14810	COG1199	ATP-dependent helicase activity
ID12_RS14815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ID12_RS14820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ID12_RS14825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ID12_RS14835	COG0617	tRNA 3'-terminal CCA addition
ID12_RS14840	COG0438	transferase activity, transferring glycosyl groups
ID12_RS14845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_RS14850	COG1803	Methylglyoxal synthase
ID12_RS14855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ID12_RS14860	COG1694	Mazg nucleotide pyrophosphohydrolase
ID12_RS14865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_RS14875	COG4347	Protein of unknown function (DUF1405)
ID12_RS14880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ID12_RS14880	COG2010	Cytochrome c
ID12_RS14885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ID12_RS14890	COG0723	plastoquinol--plastocyanin reductase activity
ID12_RS14900	COG5582	Belongs to the UPF0302 family
ID12_RS14905	COG0457	Tetratricopeptide repeat
ID12_RS14910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ID12_RS14915	COG0287	Prephenate dehydrogenase
ID12_RS14920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ID12_RS14925	COG0159	tryptophan synthase activity
ID12_RS14930	COG0133	tryptophan synthase activity
ID12_RS14935	COG0135	phosphoribosylanthranilate isomerase activity
ID12_RS14940	COG0134	indole-3-glycerol-phosphate synthase activity
ID12_RS14945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ID12_RS14955	COG4401	Chorismate mutase type I
ID12_RS14960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ID12_RS14965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ID12_RS14970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ID12_RS14975	COG0105	UTP biosynthetic process
ID12_RS14980	COG0142	geranyltranstransferase activity
ID12_RS14985	COG2226	methyltransferase
ID12_RS14990	COG0142	geranyltranstransferase activity
ID12_RS15000	COG0302	gtp cyclohydrolase
ID12_RS15005	COG0776	regulation of translation
ID12_RS15010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ID12_RS15025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ID12_RS15030	COG1160	GTP binding
ID12_RS15050	COG1304	FMN binding
ID12_RS15055	COG0539	negative regulation of cytoplasmic translation
ID12_RS15060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ID12_RS15070	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ID12_RS15075	COG2959	enzyme of heme biosynthesis
ID12_RS15080	COG3409	Peptidoglycan-binding domain 1 protein
ID12_RS15080	COG3773	Cell wall hydrolase
ID12_RS15085	COG2339	peptidase activity
ID12_RS15090	COG0492	ferredoxin-NADP+ reductase activity
ID12_RS15095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_RS15100	COG4862	establishment of competence for transformation
ID12_RS15105	COG1408	metallophosphoesterase
ID12_RS15115	COG1388	LysM domain
ID12_RS15120	COG1266	CAAX protease self-immunity
ID12_RS15125	COG0514	ATP-dependent DNA helicase (RecQ)
ID12_RS15130	COG4955	Helix-turn-helix domain
ID12_RS15135	COG1141	Ferredoxin
ID12_RS15140	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ID12_RS15145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ID12_RS15160	COG1595	DNA-templated transcription, initiation
ID12_RS15165	COG5002	protein histidine kinase activity
ID12_RS15170	COG0745	RESPONSE REGULATOR receiver
ID12_RS15175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ID12_RS15180	COG1333	cytochrome c biogenesis protein
ID12_RS15185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS15190	COG1187	pseudouridine synthase activity
ID12_RS15195	COG0700	Nucleoside recognition
ID12_RS15200	COG2715	membrane protein required for spore maturation
ID12_RS15205	COG1686	Belongs to the peptidase S11 family
ID12_RS15215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ID12_RS15220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ID12_RS15225	COG1547	Domain of unknown function (DUF309)
ID12_RS15230	COG0456	acetyltransferase
ID12_RS15235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ID12_RS15245	COG0307	riboflavin synthase, alpha
ID12_RS15265	COG2814	Major facilitator Superfamily
ID12_RS15270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ID12_RS15275	COG4086	secreted protein
ID12_RS15280	COG0019	diaminopimelate decarboxylase activity
ID12_RS15285	COG0697	spore germination
ID12_RS15300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID12_RS15320	COG1191	sigma factor activity
ID12_RS15325	COG2172	sigma factor antagonist activity
ID12_RS15335	COG1686	Belongs to the peptidase S11 family
ID12_RS15340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ID12_RS15345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ID12_RS15350	COG4974	Belongs to the 'phage' integrase family
ID12_RS15360	COG0735	belongs to the Fur family
ID12_RS15365	COG1300	Membrane
ID12_RS15370	COG1404	Belongs to the peptidase S8 family
ID12_RS15380	COG2153	protein acetylation
ID12_RS15385	COG1379	DNA repair
ID12_RS15390	COG0494	nUDIX hydrolase
ID12_RS15395	COG0667	Aldo Keto reductase
ID12_RS15405	COG1073	alpha beta
ID12_RS15410	COG0457	Tetratricopeptide repeat
ID12_RS15420	COG4918	Iron-sulphur cluster biosynthesis
ID12_RS15425	COG4305	rare lipoprotein A
ID12_RS15430	COG0456	acetyltransferase
ID12_RS15430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ID12_RS15435	COG0456	acetyltransferase
ID12_RS15445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID12_RS15455	COG2211	Major facilitator Superfamily
ID12_RS15460	COG1072	(Pantothenic acid kinase))
ID12_RS15465	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID12_RS15475	COG0300	oxidoreductase activity
ID12_RS15480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_RS15485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_RS15495	COG4187	Peptidase family M20/M25/M40
ID12_RS15500	COG1902	pentaerythritol trinitrate reductase activity
ID12_RS15505	COG0596	Alpha beta hydrolase
ID12_RS15510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_RS15520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ID12_RS15525	COG2188	Transcriptional regulator
ID12_RS15530	COG2723	6-phospho-beta-galactosidase activity
ID12_RS15535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS15540	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_RS15545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_RS15555	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS15565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ID12_RS15570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID12_RS15580	COG0706	membrane insertase activity
ID12_RS15585	COG0835	chemotaxis
ID12_RS15590	COG2195	Cleaves the N-terminal amino acid of tripeptides
ID12_RS15595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID12_RS15600	COG0346	lactoylglutathione lyase activity
ID12_RS15605	COG1376	ErfK ybiS ycfS ynhG family protein
ID12_RS15610	COG4129	membrane
ID12_RS15615	COG1126	abc transporter atp-binding protein
ID12_RS15620	COG0765	amino acid transport
ID12_RS15625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS15635	COG1597	lipid kinase activity
ID12_RS15645	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_RS15650	COG0022	dehydrogenase e1 component
ID12_RS15655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_RS15660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_RS15665	COG3426	butyrate kinase activity
ID12_RS15670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_RS15675	COG0280	phosphate acetyltransferase
ID12_RS15680	COG3290	protein histidine kinase activity
ID12_RS15680	COG3829	transcription factor binding
ID12_RS15690	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_RS15695	COG0457	Tetratricopeptide repeat
ID12_RS15700	COG0745	RESPONSE REGULATOR receiver
ID12_RS15705	COG0750	zinc metalloprotease
ID12_RS15710	COG0497	DNA recombination
ID12_RS15715	COG1438	arginine binding
ID12_RS15720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ID12_RS15725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ID12_RS15730	COG0142	geranyltranstransferase activity
ID12_RS15735	COG1722	exodeoxyribonuclease VII activity
ID12_RS15740	COG1570	exodeoxyribonuclease VII activity
ID12_RS15745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ID12_RS15750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID12_RS15755	COG1302	Protein conserved in bacteria
ID12_RS15760	COG0439	Biotin carboxylase
ID12_RS15765	COG0511	ligase activity, forming carbon-carbon bonds
ID12_RS15805	COG3854	ATPases associated with a variety of cellular activities
ID12_RS15815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ID12_RS15820	COG0006	proline dipeptidase activity
ID12_RS15825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ID12_RS15835	COG3872	metal-dependent enzyme
ID12_RS15845	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID12_RS15850	COG1321	iron dependent repressor
ID12_RS15855	COG0095	Lipoate-protein ligase
ID12_RS15860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_RS15865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID12_RS15870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID12_RS15875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ID12_RS15880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ID12_RS15900	COG0681	Belongs to the peptidase S26 family
ID12_RS15935	COG4970	Tfp pilus assembly protein FimT
ID12_RS15940	COG4537	Required for transformation and DNA binding
ID12_RS15945	COG1459	type II secretion system
ID12_RS15950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ID12_RS15955	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS15965	COG1393	Belongs to the ArsC family
ID12_RS15975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_RS15980	COG0011	TIGRFAM Protein of
ID12_RS15985	COG2814	Major facilitator Superfamily
ID12_RS15990	COG2866	Carboxypeptidase
ID12_RS15995	COG1368	sulfuric ester hydrolase activity
ID12_RS16000	COG1940	carbohydrate kinase activity
ID12_RS16005	COG4483	Protein conserved in bacteria
ID12_RS16010	COG0457	Tetratricopeptide repeat
ID12_RS16010	COG0705	Rhomboid family
ID12_RS16020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ID12_RS16025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID12_RS16040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID12_RS16045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ID12_RS16050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ID12_RS16055	COG0581	inorganic phosphate transmembrane transporter activity
ID12_RS16060	COG0573	inorganic phosphate transmembrane transporter activity
ID12_RS16065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ID12_RS16070	COG0768	penicillin binding
ID12_RS16075	COG0477	Major facilitator Superfamily
ID12_RS16080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ID12_RS16085	COG2839	Protein conserved in bacteria
ID12_RS16090	COG5521	maltodextrose utilization protein MalA
ID12_RS16095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_RS16100	COG1388	LysM domain
ID12_RS16105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ID12_RS16110	COG4709	membrane
ID12_RS16115	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ID12_RS16120	COG1940	carbohydrate kinase activity
ID12_RS16125	COG0735	belongs to the Fur family
ID12_RS16130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID12_RS16135	COG1121	(ABC) transporter
ID12_RS16140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_RS16155	COG0513	Belongs to the DEAD box helicase family
ID12_RS16165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ID12_RS16170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ID12_RS16175	COG2384	SAM-dependent methyltransferase
ID12_RS16180	COG2010	Cytochrome c
ID12_RS16185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ID12_RS16190	COG0358	DNA primase activity
ID12_RS16195	COG1671	Belongs to the UPF0178 family
ID12_RS16200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ID12_RS16205	COG0517	IMP dehydrogenase activity
ID12_RS16210	COG0751	glycine-tRNA ligase activity
ID12_RS16215	COG0752	glycyl-tRNA synthetase alpha subunit
ID12_RS16220	COG1381	Involved in DNA repair and RecF pathway recombination
ID12_RS16225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ID12_RS16230	COG0295	cytidine deaminase activity
ID12_RS16235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ID12_RS16240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ID12_RS16245	COG1480	7TM receptor with intracellular HD hydrolase
ID12_RS16250	COG1702	phosphate starvation-inducible protein PhoH
ID12_RS16255	COG0561	phosphatase activity
ID12_RS16270	COG4864	UPF0365 protein
ID12_RS16275	COG1030	water channel activity
ID12_RS16280	COG1610	YqeY-like protein
ID12_RS16290	COG1283	sodium-dependent phosphate transmembrane transporter activity
ID12_RS16295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID12_RS16300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ID12_RS16305	COG2264	protein methyltransferase activity
ID12_RS16310	COG0484	heat shock protein binding
ID12_RS16315	COG0443	Heat shock 70 kDa protein
ID12_RS16320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ID12_RS16325	COG1420	regulation of RNA biosynthetic process
ID12_RS16330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID12_RS16335	COG0481	GTPase activity
ID12_RS16345	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_RS16350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ID12_RS16355	COG0268	Binds directly to 16S ribosomal RNA
ID12_RS16360	COG1466	dna polymerase III delta subunit
ID12_RS16365	COG0658	competence protein
ID12_RS16365	COG2333	competence protein COMEC
ID12_RS16370	COG2131	deaminase
ID12_RS16375	COG1555	photosystem II stabilization
ID12_RS16375	COG1596	polysaccharide export
ID12_RS16380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_RS16385	COG2226	methyltransferase
ID12_RS16390	COG0799	negative regulation of ribosome biogenesis
ID12_RS16395	COG1713	HD superfamily hydrolase involved in NAD metabolism
ID12_RS16400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ID12_RS16405	COG1534	Rna-binding protein
ID12_RS16410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ID12_RS16415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ID12_RS16420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ID12_RS16430	COG2755	lipolytic protein G-D-S-L family
ID12_RS16440	COG0457	Tetratricopeptide repeat
ID12_RS16470	COG0726	polysaccharide deacetylase
ID12_RS16505	COG1122	ATPase activity
ID12_RS16530	COG2160	L-arabinose isomerase activity
ID12_RS16545	COG1609	Transcriptional regulator
ID12_RS16555	COG1846	Transcriptional regulator
ID12_RS16565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ID12_RS16570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ID12_RS16575	COG1733	regulation of RNA biosynthetic process
ID12_RS16580	COG0657	acetylesterase activity
ID12_RS16645	COG2602	Beta-lactamase
ID12_RS16650	COG1960	acyl-CoA dehydrogenase activity
ID12_RS16655	COG1126	abc transporter atp-binding protein
ID12_RS16660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS16665	COG0765	amino acid transport
ID12_RS16675	COG3546	catalase activity
ID12_RS16680	COG1063	alcohol dehydrogenase
ID12_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS16700	COG1115	amino acid carrier protein
ID12_RS16705	COG0583	DNA-binding transcription factor activity
ID12_RS16710	COG0842	Transport permease protein
ID12_RS16715	COG1511	domain protein
ID12_RS16715	COG0842	Transport permease protein
ID12_RS16720	COG1131	(ABC) transporter
ID12_RS16725	COG1063	alcohol dehydrogenase
ID12_RS16730	COG2226	methyltransferase
ID12_RS16740	COG0626	cystathionine gamma-synthase activity
ID12_RS16745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_RS16750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ID12_RS16755	COG2226	methyltransferase
ID12_RS16770	COG0768	penicillin binding
ID12_RS16775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID12_RS16780	COG0572	uridine kinase
ID12_RS16785	COG0826	peptidase U32
ID12_RS16790	COG0826	peptidase U32
ID12_RS16795	COG4122	O-methyltransferase activity
ID12_RS16800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID12_RS16805	COG0183	Belongs to the thiolase family
ID12_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS16815	COG1268	BioY protein
ID12_RS16820	COG3906	Belongs to the UPF0473 family
ID12_RS16825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ID12_RS16830	COG4472	Bacterial protein of unknown function (DUF965)
ID12_RS16835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ID12_RS16840	COG0628	permease
ID12_RS16845	COG1126	abc transporter atp-binding protein
ID12_RS16850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_RS16855	COG0765	amino acid transport
ID12_RS16860	COG0765	amino acid transport
ID12_RS16870	COG3881	PFAM PRC-barrel domain
ID12_RS16875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID12_RS16880	COG0457	Tetratricopeptide repeat
ID12_RS16885	COG0482	sulfurtransferase activity
ID12_RS16890	COG1104	cysteine desulfurase activity
ID12_RS16895	COG1959	2 iron, 2 sulfur cluster binding
ID12_RS16900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ID12_RS16905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ID12_RS16915	COG0124	histidyl-tRNA synthetase
ID12_RS16920	COG3103	Sh3 type 3 domain protein
ID12_RS16920	COG4991	sh3 domain protein
ID12_RS16920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_RS16925	COG1490	D-aminoacyl-tRNA deacylase activity
ID12_RS16930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ID12_RS16935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_RS16940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ID12_RS16940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ID12_RS16945	COG5416	Lipopolysaccharide assembly protein A domain
ID12_RS16950	COG0490	domain, Protein
ID12_RS16955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ID12_RS16955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ID12_RS16965	COG2244	polysaccharide biosynthetic process
ID12_RS16970	COG2323	membrane
ID12_RS16980	COG1862	Preprotein translocase
ID12_RS16985	COG0343	queuine tRNA-ribosyltransferase activity
ID12_RS16990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ID12_RS17000	COG2255	four-way junction helicase activity
ID12_RS17005	COG0632	four-way junction helicase activity
ID12_RS17015	COG2112	serine threonine protein kinase
ID12_RS17025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ID12_RS17040	COG1388	LysM domain
ID12_RS17045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ID12_RS17050	COG0157	Belongs to the NadC ModD family
ID12_RS17055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ID12_RS17060	COG1104	cysteine desulfurase activity
ID12_RS17065	COG1827	regulation of RNA biosynthetic process
ID12_RS17070	COG0077	Prephenate dehydratase
ID12_RS17075	COG4492	Belongs to the UPF0735 family
ID12_RS17080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ID12_RS17085	COG3290	protein histidine kinase activity
ID12_RS17090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ID12_RS17095	COG2868	ribosomal protein
ID12_RS17100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ID12_RS17105	COG1994	Peptidase M50
ID12_RS17110	COG0739	heme binding
ID12_RS17115	COG2894	cell division
ID12_RS17120	COG0850	regulation of cytokinetic process
ID12_RS17125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ID12_RS17135	COG1077	Cell shape determining protein MreB Mrl
ID12_RS17140	COG2003	Belongs to the UPF0758 family
ID12_RS17145	COG0424	maF-like protein
ID12_RS17160	COG0285	dihydrofolate synthase activity
ID12_RS17165	COG0525	valine-tRNA ligase activity
ID12_RS17175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_RS17180	COG1388	LysM domain
ID12_RS17185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ID12_RS17190	COG0113	porphobilinogen synthase activity
ID12_RS17195	COG1587	Uroporphyrinogen-III synthase
ID12_RS17200	COG0181	hydroxymethylbilane synthase activity
ID12_RS17205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ID12_RS17210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ID12_RS17220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ID12_RS17225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ID12_RS17230	COG0470	DNA polymerase III
ID12_RS17230	COG1067	ATP-dependent peptidase activity
ID12_RS17235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ID12_RS17240	COG0544	peptidyl-prolyl cis-trans isomerase activity
ID12_RS17245	COG0457	Tetratricopeptide repeat
ID12_RS17245	COG1477	protein flavinylation
ID12_RS17250	COG0066	3-isopropylmalate dehydratase activity
ID12_RS17255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ID12_RS17260	COG0473	3-isopropylmalate dehydrogenase activity
ID12_RS17265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ID12_RS17270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ID12_RS17275	COG0440	acetolactate synthase activity
ID12_RS17280	COG0028	Belongs to the TPP enzyme family
ID12_RS17285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_RS17290	COG2706	6-phosphogluconolactonase activity
ID12_RS17295	COG3339	Conserved Protein
ID12_RS17300	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ID12_RS17305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID12_RS17310	COG1696	Membrane protein involved in D-alanine export
ID12_RS17350	COG0622	Phosphoesterase
ID12_RS17355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ID12_RS17360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ID12_RS17365	COG5401	PFAM Sporulation and spore germination
ID12_RS17370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ID12_RS17375	COG1846	Transcriptional regulator
ID12_RS17380	COG2197	response regulator
ID12_RS17385	COG2851	Citrate transporter
ID12_RS17390	COG0583	DNA-binding transcription factor activity
ID12_RS17395	COG2828	Protein conserved in bacteria
ID12_RS17405	COG0824	Thioesterase
ID12_RS17410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ID12_RS17415	COG1053	succinate dehydrogenase
ID12_RS17420	COG2009	succinate dehydrogenase
ID12_RS17425	COG1719	4-vinyl reductase, 4VR
ID12_RS17430	COG0527	aspartate kinase activity
ID12_RS17435	COG0322	excinuclease ABC activity
ID12_RS17440	COG3118	belongs to the thioredoxin family
ID12_RS17445	COG3534	alpha-L-arabinofuranosidase
ID12_RS17450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ID12_RS17455	COG2086	electron transfer activity
ID12_RS17460	COG1024	Enoyl-CoA hydratase
ID12_RS17465	COG1309	transcriptional regulator
ID12_RS17470	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS17480	COG3766	membrane
ID12_RS17485	COG1193	negative regulation of DNA recombination
ID12_RS17490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ID12_RS17490	COG1796	DNA polymerase
ID12_RS17495	COG1286	toxin biosynthetic process
ID12_RS17500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ID12_RS17505	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID12_RS17510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_RS17510	COG0072	phenylalanine-tRNA ligase activity
ID12_RS17515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ID12_RS17520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID12_RS17530	COG1966	Carbon starvation protein
ID12_RS17535	COG1363	Peptidase, m42
ID12_RS17545	COG3326	Membrane
ID12_RS17550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ID12_RS17555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ID12_RS17560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ID12_RS17570	COG1011	Hydrolase
ID12_RS17580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_RS17590	COG0398	Pfam SNARE associated Golgi protein
ID12_RS17595	COG1484	DNA-dependent DNA replication
ID12_RS17600	COG3611	Membrane attachment protein
ID12_RS17605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ID12_RS17615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ID12_RS17620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID12_RS17625	COG0237	dephospho-CoA kinase activity
ID12_RS17630	COG1971	Probably functions as a manganese efflux pump
ID12_RS17635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ID12_RS17640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_RS17640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_RS17645	COG5002	protein histidine kinase activity
ID12_RS17650	COG0745	RESPONSE REGULATOR receiver
ID12_RS17655	COG0039	L-malate dehydrogenase activity
ID12_RS17660	COG0538	isocitrate dehydrogenase activity
ID12_RS17665	COG0372	Belongs to the citrate synthase family
ID12_RS17670	COG2707	UPF0756 membrane protein
ID12_RS17675	COG0628	permease
ID12_RS17680	COG3030	protein affecting phage T7 exclusion by the F plasmid
ID12_RS17690	COG0205	6-phosphofructokinase activity
ID12_RS17695	COG0825	malonyl-CoA metabolic process
ID12_RS17700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ID12_RS17705	COG0281	malic enzyme
ID12_RS17710	COG0587	DNA-directed DNA polymerase activity
ID12_RS17730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ID12_RS17740	COG4109	DRTGG domain
ID12_RS17745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ID12_RS17750	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_RS17760	COG0165	Argininosuccinate lyase
ID12_RS17765	COG0137	argininosuccinate synthase activity
ID12_RS17770	COG0521	Mo-molybdopterin cofactor biosynthetic process
ID12_RS17775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ID12_RS17780	COG0827	DNA restriction-modification system
ID12_RS17785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ID12_RS17790	COG3874	Sporulation protein YtfJ
ID12_RS17800	COG1714	RDD family
ID12_RS17805	COG0616	signal peptide processing
ID12_RS17810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID12_RS17820	COG3239	Fatty acid desaturase
ID12_RS17825	COG4585	Histidine kinase
ID12_RS17830	COG2197	response regulator
ID12_RS17835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_RS17840	COG0745	RESPONSE REGULATOR receiver
ID12_RS17845	COG2205	protein histidine kinase activity
ID12_RS17850	COG0772	Belongs to the SEDS family
ID12_RS17855	COG1695	Transcriptional regulator
ID12_RS17860	COG1136	(ABC) transporter
ID12_RS17865	COG0577	efflux transmembrane transporter activity
ID12_RS17870	COG0402	S-adenosylhomocysteine deaminase activity
ID12_RS17875	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_RS17890	COG1279	arginine transmembrane transporter activity
ID12_RS17895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ID12_RS17905	COG0301	tRNA thio-modification
ID12_RS17910	COG1104	cysteine desulfurase activity
ID12_RS17915	COG1114	Component of the transport system for branched-chain amino acids
ID12_RS17920	COG1114	Component of the transport system for branched-chain amino acids
ID12_RS17925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ID12_RS17930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ID12_RS17935	COG1309	transcriptional regulator
ID12_RS17940	COG1956	GAF domain-containing protein
ID12_RS17945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ID12_RS17955	COG1335	isochorismatase
ID12_RS17965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ID12_RS17970	COG2329	Antibiotic biosynthesis monooxygenase
ID12_RS17975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ID12_RS17980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ID12_RS17985	COG0454	-acetyltransferase
ID12_RS17990	COG0517	IMP dehydrogenase activity
ID12_RS17995	COG0123	including yeast histone deacetylase and acetoin utilization protein
ID12_RS18000	COG1609	Transcriptional regulator
ID12_RS18005	COG1605	Chorismate mutase
ID12_RS18005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ID12_RS18010	COG3118	belongs to the thioredoxin family
ID12_RS18015	COG4980	gas vesicle protein
ID12_RS18020	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ID12_RS18025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ID12_RS18030	COG1674	ftsk spoiiie
ID12_RS18035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_RS18040	COG4848	Belongs to the UPF0354 family
ID12_RS18045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_RS18060	COG1363	Peptidase, m42
ID12_RS18065	COG5584	Small secreted protein
ID12_RS18070	COG0281	malic enzyme
ID12_RS18075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_RS18080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ID12_RS18090	COG0510	thiamine kinase activity
ID12_RS18095	COG1597	lipid kinase activity
ID12_RS18105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ID12_RS18110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_RS18115	COG3340	Belongs to the peptidase S51 family
ID12_RS18120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID12_RS18125	COG2252	PERMEase
ID12_RS18130	COG1349	DNA-binding transcription factor activity
ID12_RS18135	COG1187	pseudouridine synthase activity
ID12_RS18140	COG2244	polysaccharide biosynthetic process
ID12_RS18145	COG2081	HI0933 family
ID12_RS18155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ID12_RS18160	COG3196	Protein conserved in bacteria
ID12_RS18170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_RS18175	COG5578	integral membrane protein
ID12_RS18180	COG0673	inositol 2-dehydrogenase activity
ID12_RS18185	COG1653	transport
ID12_RS18190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ID12_RS18195	COG4209	transmembrane transport
ID12_RS18200	COG2207	Transcriptional regulator
ID12_RS18205	COG1733	regulation of RNA biosynthetic process
ID12_RS18210	COG2814	Major facilitator Superfamily
ID12_RS18215	COG0656	L-ascorbic acid biosynthetic process
ID12_RS18220	COG1653	transport
ID12_RS18225	COG0395	ABC-type sugar transport system, permease component
ID12_RS18230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_RS18235	COG1073	alpha beta
ID12_RS18240	COG0495	leucyl-tRNA aminoacylation
ID12_RS18250	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_RS18250	COG2202	Pas domain
ID12_RS18255	COG2433	Pfam Transposase IS66
ID12_RS18260	COG0577	efflux transmembrane transporter activity
ID12_RS18265	COG1136	(ABC) transporter
ID12_RS18275	COG1131	(ABC) transporter
ID12_RS18280	COG1725	Transcriptional regulator
ID12_RS18295	COG1242	4 iron, 4 sulfur cluster binding
ID12_RS18300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ID12_RS18305	COG4326	sporulation control protein
ID12_RS18315	COG2267	carboxylic ester hydrolase activity
ID12_RS18320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ID12_RS18325	COG0367	asparagine synthase
ID12_RS18330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ID12_RS18335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ID12_RS18345	COG1506	peptidase
ID12_RS18350	COG1233	COG1233 Phytoene dehydrogenase and related
ID12_RS18370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ID12_RS18375	COG1116	anion transmembrane transporter activity
ID12_RS18380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ID12_RS18385	COG0494	nUDIX hydrolase
ID12_RS18390	COG2310	stress, protein
ID12_RS18405	COG4824	toxin secretion phage lysis holin
ID12_RS18415	COG0783	Belongs to the Dps family
ID12_RS18430	COG1854	S-ribosylhomocysteine lyase activity
ID12_RS18435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ID12_RS18440	COG0288	reversible hydration of carbon dioxide
ID12_RS18445	COG3443	Belongs to the bacterial solute-binding protein 9 family
ID12_RS18445	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID12_RS18455	COG1271	oxidase subunit
ID12_RS18460	COG1294	oxidase, subunit
ID12_RS18470	COG4948	Mandelate Racemase Muconate Lactonizing
ID12_RS18475	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_RS18480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ID12_RS18485	COG0596	Alpha beta hydrolase
ID12_RS18490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ID12_RS18495	COG1169	isochorismate synthase
ID12_RS18500	COG1575	Belongs to the MenA family. Type 1 subfamily
ID12_RS18505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters